ADVS - 4043

• (2025). Nanoshield-assisted viral gene therapy with induction of non-apoptotic cell death and durable antitumor immunity (Adv. sci. 41/2025). ADVS, 12(41), e72232. (www)

  @article{ , archive = {J_ADVS}, author = {Soo-Hwan Lee and Yunkyeong Cho and Seunghwan Bang and Daeun Sung and Jahyun Koo and Seoyoung Kim and Youngil Koh and Hojun Kim and Hyojin Lee}, doi = {10.1002/advs.72232}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e72232}, shortjournal = {Adv. Sci.}, title = {Nanoshield-assisted viral gene therapy with induction of non-apoptotic cell death and durable antitumor immunity (Adv. sci. 41/2025)}, volume = {12}, year = {2025}, }
• (2025). A prion-like domain in EBV EBNA1 promotes phase separation and enables SRRM1 splicing (Adv. sci. 41/2025). ADVS, 12(41), e72231. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaoyue Zhang and Zhengshuo Li and Run Zheng and Xiang Zheng and Jia Wang and Can Liu and Yangge Wu and Yuqing Wen and Chunlin Ou and Songqing Fan and Chenxiao Xu and Junrui Tian and Qun Yan and Hao Nan and Xiaodong Xu and Hui Wang and Qiu Peng and Jian Ma}, doi = {10.1002/advs.72231}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e72231}, shortjournal = {Adv. Sci.}, title = {A prion-like domain in EBV EBNA1 promotes phase separation and enables SRRM1 splicing (Adv. sci. 41/2025)}, volume = {12}, year = {2025}, }
• (2025). Microphysiological solid tumor models in hydrogel beads for CAR t cell immunotherapy evaluation (Adv. sci. 41/2025). ADVS, 12(41), e72230. (www)

  @article{ , archive = {J_ADVS}, author = {Xuan Peng and Željko Janićijević and Liliana R. Loureiro and Lydia Hoffmann and Poh Soo Lee and Isli Cela and Benjamin Kruppke and Alexandra Kegler and Anja Feldmann and Ielizaveta Gorodetska and Anja Madleine Markl and Anna Dubrovska and Anne Kathrin Offermann and Michael Bachmann and Larysa Baraban}, doi = {10.1002/advs.72230}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e72230}, shortjournal = {Adv. Sci.}, title = {Microphysiological solid tumor models in hydrogel beads for CAR t cell immunotherapy evaluation (Adv. sci. 41/2025)}, volume = {12}, year = {2025}, }
• (2025). Suppressing the Electron–Phonon coupling in 2D perovskite Cs3Sb2I9 for lead-free indoor photovoltaics (Adv. sci. 41/2025). ADVS, 12(41), e72229. (www)

  @article{ , archive = {J_ADVS}, author = {Yixin Guo and Fei Zhao and Chuanjun Zhang and Ping Wu and Jinchun Jiang and Jiahua Tao and Junhao Chu}, doi = {10.1002/advs.72229}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e72229}, shortjournal = {Adv. Sci.}, title = {Suppressing the Electron–Phonon coupling in 2D perovskite Cs3Sb2I9 for lead-free indoor photovoltaics (Adv. sci. 41/2025)}, volume = {12}, year = {2025}, }
• (2025). Advanced microfluidics for single cell-based cancer research (Adv. sci. 41/2025). ADVS, 12(41), e72228. (www)

  @article{ , archive = {J_ADVS}, author = {Adriana Carneiro and Marta Aranda Palomer and Margarida Esteves and Carolina Rodrigues and José Maria Fernandes and Francisca Oliveira and Alexandra Teixeira and Carlos Honrado and Lorena Dieguez and Sara Abalde-Cela and Miguel Xavier}, doi = {10.1002/advs.72228}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e72228}, shortjournal = {Adv. Sci.}, title = {Advanced microfluidics for single cell-based cancer research (Adv. sci. 41/2025)}, volume = {12}, year = {2025}, }
• (2025). Human iPSC-derived mononuclear phagocytes improve cognition and neural health across multiple mouse models of aging and alzheimer's disease. ADVS, 12(41), e17848. (www)

  @article{ , abstract = {Young blood or plasma improves cognitive function in aged animals but has limited availability. The current study generates a subtype of young blood cells from easily expandable induced pluripotent stem cells and evaluates their effects on age- and Alzheimer's disease (AD)-associated cognitive and neural decline. In aging mice, intravenous delivery of induced mononuclear phagocytes (iMPs) improves performance in hippocampus-dependent cognitive tasks, increases neural health, and reduces neuroinflammation. Hippocampal single nucleus RNA-sequencing shows that iMPs improve the health of a subpopulation of mossy cells that are critically involved in the type of cognitive task in which iMPs improve performance, and shows that iMPs decrease the transcriptional age of several hippocampal cell types. Plasma proteomic analyses reveal that iMPs can also reverse age-associated increases in serum amyloid levels. This is verified in vitro, where iMP-conditioned media is shown to protect human microglia against cell death induced by serum amyloids. Finally, iMPs improve cognition in both young and aging 5×FAD mice, highlighting their potential as a prevention as well as an intervention strategy. Together, these findings suggest that iMPs provide a novel therapeutic strategy to target both age- and AD-related cognitive decline.}, archive = {J_ADVS}, author = {V. Alexandra Moser and Luz Jovita Dimas-Harms and Rachel M. Lipman and Jake Inzalaco and Shaughn Bell and Michelle Alcantara and Erikha Valenzuela and George Lawless and Simion Kreimer and Sarah J. Parker and Helen S. Goodridge and Clive N. Svendsen}, doi = {10.1002/advs.202417848}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e17848}, shortjournal = {Adv. Sci.}, title = {Human iPSC-derived mononuclear phagocytes improve cognition and neural health across multiple mouse models of aging and alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Emodin alleviates sepsis-induced multiorgan damage by inhibiting NETosis through targeting neutrophils BCL-10. ADVS, 12(41), e17129. (www)

  @article{ , abstract = {Sepsis is a life-threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation. Neutrophil extracellular traps (NETs) formation bridges these two pathological processes. Through both in vivo and in vitro experiments, it is observed that Emodin, a natural anthraquinone derivative derived from Dahuang, significantly ameliorates the cytokine storm and coagulation abnormalities induced by sepsis, demonstrating remarkable efficacy in inhibiting NETs formation. Furthermore, through protein microarrays, surface plasmon resonance (SPR), pull-down assays, and molecular docking analyses, BCL-10 is established as a direct target of Emodin, providing protective effects in both in vivo and in vitro settings. Through conditional knockout of BCL-10 in neutrophils, alongside single-cell sequencing analyses, it is confirmed that BCL-10 is key in promoting excessive NET formation in sepsis. Additionally, Emodin exerts powerful protective effects by modulating the function of the BCL-10/MALT1 complex, thereby alleviating the NF-κB signaling activation and inhibiting NETs formation. Collectively, these findings provide pharmacological evidence that Emodin targeted BCL-10 regulates the BCL-10/MALT1 complex and suppresses NF-κB activation, ultimately conferring significant multiorgan protective effects in sepsis. The conduct of this study provides new clues for the translational research of Emodin and its target BCL-10 in sepsis.}, archive = {J_ADVS}, author = {Xiaolong Xu and Yumeng Yan and Meiling Zheng and Mina Zhang and Tengfei Chen and Zhicheng Qu and Yinglu Bai and Shuwen Zhang and Chunming Zhao and Yifan Shi and Yan Lin and Ning Wang and Yunjing Bai and Yating Zhai and Zhaofang Bai and Wei Guo and Qingquan Liu}, doi = {10.1002/advs.202417129}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e17129}, shortjournal = {Adv. Sci.}, title = {Emodin alleviates sepsis-induced multiorgan damage by inhibiting NETosis through targeting neutrophils BCL-10}, volume = {12}, year = {2025}, }
• (2025). Cuproptosis signature would reveal the acute-remitting pattern in patients with neuromyelitis optica spectrum disorder. ADVS, 12(41), e17124. (www)

  @article{ , abstract = {The acute-remitting course (the time interval from remission to the next relapse) is a distinct signature of neuromyelitis optica spectrum disorder (NMOSD), which harms patients and perplexes physicians. However, clinically actionable biomarkers to anticipate NMOSD relapse timing are unavailable. Recently, it is found that Cuproptosis-related genes would have an impact on the acute-remitting course in patients with aquaporin-4 (AQP4)-immunoglobulin G antibody positive NMOSD. A machine learning-based algorithm is developed to construct a consensus Cuproptosis-related prognosis risk (CRPR) model, followed by training a proportional hazards model to divide patients with NMOSD into high/low relapse risk groups. The CRPR is related to the clinical symptoms of patients with NMOSD. Finally, a nomogram is created using CRPR to predict the possibility of relapse in new cases of NMOSD. This prediction model can assist physicians and help develop appropriate interventions to prevent disease relapse.}, archive = {J_ADVS}, author = {Peidong Liu and Ruoyu Li and Xinlin Wang and Hui Li and Huiru Hu and Ang Shen and Wenping Zhu and Jiali Pan and Yanmeng Xing and Weiming Xia and Henan Jiao and Di Chen and Lixin Wu and Li Liu and Ju Liu and Bin Yu and Xianzhi Liu and Hongbo Liu}, doi = {10.1002/advs.202417124}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e17124}, shortjournal = {Adv. Sci.}, title = {Cuproptosis signature would reveal the acute-remitting pattern in patients with neuromyelitis optica spectrum disorder}, volume = {12}, year = {2025}, }
• (2025). Transcriptome-wide association uncovers LncRNAs controlling seed weight in soybean. ADVS, 12(41), e16794. (www)

  @article{ , abstract = {Long non-coding RNAs (lncRNAs) are emerging as key regulators of various biological processes in plants, yet their role in seed weight regulation remains underexplored. To systematically investigate lncRNAs associated with seed weight variation, transcriptome-wide association studies (TWAS) are performed across a diversity panel of 238 soybean accessions. The analysis identifies 175 and 50 TWAS-significant lncRNAs at 14 and 21 days after flowering, respectively. Functional validation reveals that two candidate lncRNAs positively regulate seed weight through transcriptional modulation of key genes in seed development pathways. Additionally, an lncRNA-lncRNA co-expression module is identified as significantly correlated with seed weight. The eQTL analysis reveals dynamic and static eQTLs that coordinately modulate lncRNA expression across seed developmental stages. Notably, integration of major-effect proximal and minor-effect distal eQTLs enhances phenotype prediction of seed weight, underscoring the significant impact of distal eQTLs on phenotypic variation. These findings elucidate the intricate mechanisms by which lncRNAs contribute to seed weight regulation, offering novel insights for enhancing crop yield.}, archive = {J_ADVS}, author = {Xiang Wang and Xinyu Jiang and Xiaobo Yuan and Zhipeng Zhou and Zhenwei Zhao and Longfei Wang and Wu Jiao and Wenxue Ye and Qingxin Song}, doi = {10.1002/advs.202416794}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e16794}, shortjournal = {Adv. Sci.}, title = {Transcriptome-wide association uncovers LncRNAs controlling seed weight in soybean}, volume = {12}, year = {2025}, }
• (2025). Comment on “Development and validation of machine learning-based marker for early detection and prognosis stratification of nonalcoholic fatty liver disease”. ADVS, 12(41), e15549. (www)

  @article{ , archive = {J_ADVS}, author = {Hongye Peng and Shaojie Duan}, doi = {10.1002/advs.202515549}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e15549}, shortjournal = {Adv. Sci.}, title = {Comment on “Development and validation of machine learning-based marker for early detection and prognosis stratification of nonalcoholic fatty liver disease”}, volume = {12}, year = {2025}, }
• (2025). M2 macrophages are major mediators of germline risk of endometriosis and explain pleiotropy with comorbid traits. ADVS, 12(41), e15285. (www)

  @article{ , abstract = {Endometriosis is a common gynecologic condition that causes chronic, life-altering symptoms including pain and infertility. There is an urgent need for new non-hormonal targeted therapeutics to treat endometriosis, but until very recently, the cellular and molecular signatures of endometriotic lesions are undefined, hindering the development of clinical advances. Integrating inherited risk data from analyses of >45 0000 individuals with ≈35 0000 single-cell transcriptomes from 21 patients, M2-macrophages as candidate drivers of disease susceptibility are uncovered, and nominating IL1 signaling as a central hub impacted by germline genetic variation associated with endometriosis risk. Extensive functional follow-up confirmed these associations and revealed a pleiotropic role for this pathway in endometriosis. Population-scale expression quantitative trait locus analysis demonstrates that genetic variation controlling IL1A expression is associated with endometriosis risk variants. Manipulation of IL1 signaling in state-of-the-art in vitro decidualized endometrial organoids impacts epithelial differentiation, and in an in vivo endometriosis model, treatment with anakinra (an interleukin-1 receptor antagonist) results in a significant, dose-dependent reduction in spontaneous and evoked pain and dampened pro-angiogenic signaling. Together, these studies highlight non-diagnostic cell types as central to endometriosis susceptibility and support IL1 signaling as an important actionable pathway for this disease.}, archive = {J_ADVS}, author = {Soledad Ochoa and Fernanda S. Rasquel-Oliveira and Brett McKinnon and Marcela Haro and Sugarniya Subramaniam and Pak Yu and Simon Coetzee and Michael S. Anglesio and Kelly N. Wright and Raanan Meyer and Anne E. Porter and Caroline E. Gargett and Sally Mortlock and Grant W. Montgomery and Michael S. Rogers and Kate Lawrenson}, doi = {10.1002/advs.202415285}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e15285}, shortjournal = {Adv. Sci.}, title = {M2 macrophages are major mediators of germline risk of endometriosis and explain pleiotropy with comorbid traits}, volume = {12}, year = {2025}, }
• (2025). Perceptual bias in motion discrimination is related to asymmetric interhemispheric alpha traveling waves. ADVS, 12(41), e14623. (www)

  @article{ , abstract = {Perception relies on hierarchical processes integrating sensory data into higher-order models about the world. In the sensory domain, this hierarchy also involves horizontal pathways aiding interhemispheric interactions. For example, recent focus on the V5-V5 network revealed its role in motion processing. However, despite converging evidence demonstrating the crucial role of oscillatory activity in inter-areas communication, the specific rhythmic code governing V5-V5 interaction is unclear. Through traveling wave analysis, this gap is filled by identifying the alpha/low-beta frequency (9–16 Hz) as crucial for long-range, interhemispheric communication between V5 regions. Notably, a pronounced imbalance is observed: stronger waves travelled in the left-to-right-V5 direction. Crucially, this observation extends to the behavioural level, as Signal Detection Theory analysis uncovered a correlation between the highlighted imbalance and a perceptual bias favouring leftward motion reporting. Our findings underscore asymmetrical projections between V5 regions, highlighting the interplay between inter-hemispheric traveling wave patterns in dictating motion perception.}, archive = {J_ADVS}, author = {Luca Tarasi and Andrea Alamia and Vincenzo Romei}, doi = {10.1002/advs.202414623}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e14623}, shortjournal = {Adv. Sci.}, title = {Perceptual bias in motion discrimination is related to asymmetric interhemispheric alpha traveling waves}, volume = {12}, year = {2025}, }
• (2025). Mechanotransduction in shaping immunity: Pathways, crosstalk, and pathophysiological relevance. ADVS, 12(41), e12164. (www)

  @article{ , abstract = {The immune system serves as a crucial line of defense against pathogens and abnormal cells throughout the entire life cycle. While chemical interactions among immune cells play a prominent role in the immune response, the manner in which physical factors, such as mechanical forces, shape the behaviors and functions of immune cells remains inadequately understood. This is particularly noteworthy given that the lifespan of an immune cell is characterized by a series of physical processes. This review first synthesizes current understanding of how immune cells respond to biomechanical cues via mechanotransduction cascades, which encompass mechanosensors that detect mechanical stimuli, mechanotransducers that propagate signals, and mechanoeffectors that execute cellular responses. Furthermore, this is delved into the mechanical crosstalk among immune cells themselves and between the extracellular matrix (ECM), as well as with other cell types. the emerging significance of mechanoimmunology is highlighted in both health and disease contexts. Overall, this review will give insight into the role of mechanotransduction in shaping immunity is hoped, providing inspiration for advancements in mechanobiology-based immunotherapeutic strategies in the future.}, archive = {J_ADVS}, author = {Ruijiao Yan and Yuyu Li and Shuo Chen and Li Zhu and Chenchen Zhou and Jianwei Chen and Shujuan Zou and Xianglong Han}, doi = {10.1002/advs.202512164}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e12164}, shortjournal = {Adv. Sci.}, title = {Mechanotransduction in shaping immunity: Pathways, crosstalk, and pathophysiological relevance}, volume = {12}, year = {2025}, }
• (2025). Friction-assisted liquid metal-driven anchoring of low redox potential metal ions for enhanced electromagnetic wave absorption. ADVS, 12(41), e11810. (www)

  @article{ , abstract = {Overcoming the fundamental thermodynamic-kinetic dilemma restricting metal ion reduction/anchoring (MIRA) strategies is critical for advancing next-generation technologies reliant on precise electron transfer and stable interfaces. However, the persistent challenge in conventional approaches lies in the concurrent inhibition of thermodynamically reactions, occurrence of undesired kinetic pathways, and compromised anchoring efficiency. Here, a paradigm of friction-assisted utilizing gallium-indium liquid metal (LM) to circumvent these constraints, enabling efficient MIRA of low reduction potential (LRP) ions. This study elucidates the mechanism by which friction-assisted LM promotes the MIRA of LRP, overcoming thermodynamic barriers, suppressing parasitic reactions, and enabling efficient anchoring. Building on this principle, InGaZn 5 O 8 with a distinct crystalline structure is synthesized, whose unique electronic configuration engenders enhanced electromagnetic wave absorption. A concentration-dependent dual effective absorption bandwidth (EAB) phenomenon is observed, and optimized LM-Zn-8 achieves an EAB of 5.92 GHz at a minimal thickness of 1.3 mm and a minimum reflection loss (RL min ) of -44.44 dB. Furthermore, the friction-assisted strategy demonstrates broad applicability to diverse LRP ions (e.g., Al 3 ⁺, Cr 3 ⁺), establishing a universal and customizable platform for fabricating MIRA composites with tailored functionalities across a wide range of applications.}, archive = {J_ADVS}, author = {Tao Zhang and Geng Chen and Lechun Deng and Limin Zhang and Hao Shen and Qiang Chen and Hu Liu and Hongjing Wu}, doi = {10.1002/advs.202511810}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e11810}, shortjournal = {Adv. Sci.}, title = {Friction-assisted liquid metal-driven anchoring of low redox potential metal ions for enhanced electromagnetic wave absorption}, volume = {12}, year = {2025}, }
• (2025). PIEZO force sensing in vascular biology: An explosion of new knowledge, concepts and opportunity. ADVS, 12(41), e11774. (www)

  @article{ , abstract = {The discovery of PIEZO1 channels as robust, rapidly activating, electrically transducing mechanical force sensors of endothelial biology led to intense research efforts that have transformed the appreciation and understanding of pivotal relationships between mechanical forces and cardiovascular health. This narrative review of the scientific literature highlights discoveries about the PIEZOs, PIEZO1 and PIEZO2, in vascular biology from the embryo to adult stages including in vascular and valve formations, vascular expansion and arrest, lymphatic and venous integrity, blood pressure regulation, the aortic baroreceptor reflex, microvascular density for muscle and physical exercise capabilities and the regulation of lipid homeostasis, cerebral hyperemia and leukocyte extravasation. Concepts are discussed for how the channels work at the molecular level and integrate with other cell components and how they signal downstream for appropriate tissue responses. A PIEZO-centric hypothesis is debated for the core fluid flow sensing property of cardiovascular biology. PIEZO contributions to vascular and vascular related disease problems are discussed. In summary, this is an exciting area of research that is revolutionizing the understanding of the cardiovascular system and revealing new ways to address unsolved cardiovascular disease.}, archive = {J_ADVS}, author = {David J Beech}, doi = {10.1002/advs.202511774}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e11774}, shortjournal = {Adv. Sci.}, title = {PIEZO force sensing in vascular biology: An explosion of new knowledge, concepts and opportunity}, volume = {12}, year = {2025}, }
• (2025). Orchestrating multi-Ångstrom spaced Cu─Ni dual-atom pair for synergistic C─H activation in direct methane oxidation to methanol. ADVS, 12(41), e11661. (www)

  @article{ , abstract = {Direct and efficient methane oxidation to methanol is an appealing route for upgrading abundant methane resources while acquiring building blocks of clean fuels and chemicals. However, owing to its highly symmetrical nature imparted chemical stability and steric hindrance, the design of multi-ångstrom (<3.0 Å) spaced active species capable of activating its first C−H bond remains a fundamental challenge. Herein, Cu−Ni dual-atom Pair is constructed using defect engineering and a stepwise deposition method over indium oxide to precisely modulate the C−H polarization with the Cu atom showing affinity to H end and Ni anchoring the C side. The optimal CuNi/InNT achieves an oxygenates (CH 3 OH and CH 3 OOH) productivity of 106 mmol g cat h −1 , surpassing reported systems. Theoretical calculations validate the dominating role of interatomic distance for methane activation. Specifically, the dual-atom orbital coupling effect in the minimally spaced Cu−Ni pair up-shifts the overall d-band center, significantly enhancing its hybridization with C/O 2p. Further modification through macroscopic reactor design boosts CH 3 OH yield to 36818.84 µmol g cat h −1 with 79.37% selectivity in a 1000 mL semi-industrial prototype. This work provides a comprehensive explanation of the Cu−Ni synergy, bridging atomic-scale catalysis with reactor design, and establishes a common design principle for binary catalysts at the electron and orbital level.}, archive = {J_ADVS}, author = {Jingting Jin and Wenzhi Li and Liqun Wang and Lulu Zhang and Xia Zhang}, doi = {10.1002/advs.202511661}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e11661}, shortjournal = {Adv. Sci.}, title = {Orchestrating multi-Ångstrom spaced Cu─Ni dual-atom pair for synergistic C─H activation in direct methane oxidation to methanol}, volume = {12}, year = {2025}, }
• (2025). Mechanical stretch-induced interlayer coordination between MMP2 and COL17A1 exacerbates regenerative exhaustion in skin. ADVS, 12(41), e11474. (www)

  @article{ , abstract = {The layered structure of skin necessitates highly sophisticated tissue coordination during regeneration. The unmet clinical need of long-term skin expansion therapy stems from limited regenerative capacity, yet the underlying mechanism remains enigmatic due to the lack of appropriate animal model. A mouse scalp-based mechanical stretch model is established that mimics clinical long-term skin expansion. Prolonged skin expansion progressively drives interfollicular epidermal stem cells towards a state of irreversible regenerative exhaustion, marked by impaired proliferation, differentiation, adhesion, and activity. Mechanistically, mechano-stress-induced accumulation of MMP2 in the dermis mediates a shift in extracellular matrix turnover from deposition to degradation, impairing stem cell activity, disrupting niche integrity, and simultaneously triggering proteolysis of COL17A1 at the interlayer. Restoring COL17A1, either through genetic overexpression or administration of Marimastat, a protease inhibitor, is sufficient to mitigate regenerative exhaustion. Consistently, in patient-derived skin samples, COL17A1 levels correlate with ECM integrity and regenerative potential. Combined, a new stretch-induced skin expansion model is established, revealing hidden components underlying regenerative exhaustion, and proposing Marimastat for drug repurposing. Restoration of COL17A1 is proposed to provide clinical benefits for skin expansion therapy.}, archive = {J_ADVS}, author = {Yidan Sun and Qili Qian and Luwen Xu and Bowen Gao and Ting Li and Yin Li and Jiayi Zheng and Qiaoyu Fu and Xi Cheng and Nuo Chen and Sijia Wang and Liang Zhang and Caiyue Liu and Qingfeng Li}, doi = {10.1002/advs.202511474}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e11474}, shortjournal = {Adv. Sci.}, title = {Mechanical stretch-induced interlayer coordination between MMP2 and COL17A1 exacerbates regenerative exhaustion in skin}, volume = {12}, year = {2025}, }
• (2025). Sustainable MXene/Conductive cellulose heteroinks for 3D printed high areal energy density micro-supercapacitors and self-powered integrated systems. ADVS, 12(41), e11439. (www)

  @article{ , abstract = {The additive manufacturing of micro-supercapacitors (MSCs) with outstanding areal energy density and scalable integration remains challenging due to the incompatibility between printability and functionality of electronic ink. Here, a thixotropic MXene/conductive cellulose heteroink is formulated, eliminating the need for tedious processing and toxic organic additives, to construct MSCs with high areal energy density. Conductive cellulose with radially graded structure containing defect-rich graphitic shells not only inhibits MXene re-stacking through hydrogen-bonded 3D porous networks, but also establishes sp 2 -carbon pathways for rapid electron transport. The optimized 3D printed MSCs achieve record-breaking metrics: high areal capacitance of 3.12 F cm −2 (1 mA cm −2 ), outstanding energy density of 1.25 mWh cm −2 , and 95% capacitance retention after 10 000 bending cycles. Notably, the 3D printed MSCs can operate stably within a temperature range of −40 to 60 °C. In addition, an integrated flexible sensing system incorporating 3D printed MSCs and strain sensors is demonstrated, which is highly sensitive for real-time motion monitoring. This work establishes a materials-by-design paradigm for customizable micro-energy systems, advancing wearable and implantable electronics.}, archive = {J_ADVS}, author = {Chunling Cao and Shiyao Tang and Xiaofei Wu and Haibo Huang and Shouxin Liu and Hongpeng Li}, doi = {10.1002/advs.202511439}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e11439}, shortjournal = {Adv. Sci.}, title = {Sustainable MXene/Conductive cellulose heteroinks for 3D printed high areal energy density micro-supercapacitors and self-powered integrated systems}, volume = {12}, year = {2025}, }
• (2025). Large-scale flat silk cocoons as a highly effective salt-resistant low-cost solar-powered evaporator. ADVS, 12(41), e11284. (www)

  @article{ , abstract = {Solar seawater evaporators are a promising sustainable solution for freshwater production, yet they face challenges related to efficiency, evaporation rate, salt resistance, and the large-scale manufacturing of evaporative materials. Here, we demonstrate that flat silk cocoons (FSC), produced in large sizes (70 cm × 200 cm) by utilizing silkworms to spin silk fibers on flat surfaces, serve as evaporators with remarkable performance in salt resistance and evaporation. Specifically, the FSC s modified into a Janus-structured evaporator (FJE) by coating the top (thin) portion with superhydrophobic polydimethylsiloxane and the bottom (thick) portion with superhydrophilic polypyrrole. The Janus structure enables the FJE to transport water to the superhydrophilic/hydrophobic interface through its bottom portion and evaporate without salt precipitation. Simultaneously, the top portion absorbs sunlight and transfers heat to the bottom portion within the evaporator, promoting evaporation while minimizing heat loss. The FJE demonstrates exceptional cost-effectiveness (258.2 g h −1 USD −1 ), high evaporation rate (3.075 kg m 2 h −1 ), and an impressive evaporation efficiency (79.73%). Notably, the superhydrophilic layer of the Janus structure enhances water exchange, enabling sustained evaporation for 18 h in 20 wt.% saline solutions without salt deposition under sunlight. The FJE represents a new generation of eco-friendly, cost-effective, salt-resistant, and thermo-localized evaporators.}, archive = {J_ADVS}, author = {Tiancheng Wei and Qichao Cheng and Leihao Lu and Quan Wan and Qi Wu and Ruixi Shao and Zongpu Xu and Jie Wang and Yajun Shuai and Chuanbin Mao and Mingying Yang}, doi = {10.1002/advs.202511284}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e11284}, shortjournal = {Adv. Sci.}, title = {Large-scale flat silk cocoons as a highly effective salt-resistant low-cost solar-powered evaporator}, volume = {12}, year = {2025}, }
• (2025). Electric-field control of low damping constant in epitaxial Co2FeSi/LiNbO3 multiferroic heterostructures. ADVS, 12(41), e11250. (www)

  @article{ , abstract = {To develop electric-field control of magnetization dynamics in a magnetic material for magnonic devices with low-energy power consumption operation, an epitaxial half-metallic Co 2 FeSi/LiNbO 3 multiferroic heterostructure is experimentally demonstrated. The epitaxial Co 2 FeSi/LiNbO 3 multiferroic heterostructure shows a low damping constant (α) of ∼0.006 and the value of α is decreased to ∼0.004 by applying an electric field. This means that the magnetization dynamics in an epitaxial half-metallic Co 2 FeSi layer can be controlled via the piezoelectric strain of LiNbO 3 through the magnetoelastic coupling. This study leads to a way toward the realization of magnonic devices with low-energy power consumption operation.}, archive = {J_ADVS}, author = {Shinya Yamada and Takamasa Usami and Sachio Komori and Yoshio Miura and Kazuto Yamanoi and Yukio Nozaki and Tomoyasu Taniyama and Kohei Hamaya}, doi = {10.1002/advs.202511250}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e11250}, shortjournal = {Adv. Sci.}, title = {Electric-field control of low damping constant in epitaxial Co2FeSi/LiNbO3 multiferroic heterostructures}, volume = {12}, year = {2025}, }
• (2025). Durable lithium metal anodes enabled by {110}-textured epitaxy on a LiF@Ag commensurate heterostructure. ADVS, 12(41), e10886. (www)

  @article{ , abstract = {Lithium metal anodes (LMAs) hold great promise for high-energy storage, but their practical application is hindered by challenges such as Li dendrite growth and unstable solid electrolyte interphase. Designing heteroepitaxial substrates to guide {110}-textured Li growth is a promising strategy to suppress dendrite formation and parasitic reactions. LiF and Ag are potential candidates owing to their low lattice mismatch with Li, whilst the former lacks sufficient lithiophilicity and the latter suffers from Li-Ag alloying. A LiF@Ag commensurate heterostructure composed of Ag nanoparticles (NPs) uniformly grown on 2D LiF layers is hence proposed, where the composition pinning effect prevents Li-Ag alloying and stabilizes the lithiophilic Ag NPs upon Li plating. Meanwhile, Ag contributes to a significantly reduced Li adatom diffusion barrier compared with LiF, providing a synergistic effect of low lattice mismatch and improved interfacial dynamics to promote Li heteroepitaxy. Ultra-dense and dendrite-free Li heteroepitaxial deposition with prominent {110} texture is achieved, which enables improved coulombic efficiency, enhanced high-rate capability, and prolonged cycle life in Li metal full cells with a low negative-to-positive ratio. The results demonstrate that constructing commensurate heterostructures offers a new synergistic strategy to regulate both deposition thermodynamics and kinetics toward high-performance {110}-textured LMAs.}, archive = {J_ADVS}, author = {Liming Zhang and Xuemin Wang and Xiaotong Sun and Haobo Yang and Xinyi Miao and Zifeng Gu and Chuanzhong Chen and Cheng Hu}, doi = {10.1002/advs.202510886}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10886}, shortjournal = {Adv. Sci.}, title = {Durable lithium metal anodes enabled by {110}-textured epitaxy on a LiF@Ag commensurate heterostructure}, volume = {12}, year = {2025}, }
• (2025). Ultrasmall hollow covalent triazine framework Nanosphere/Aramid nanofiber composite separator for high-energy lithium metal batteries. ADVS, 12(41), e10757. (www)

  @article{ , abstract = {Sluggish and uneven mass transport in separators significantly accelerates lithium metal batteries (LMBs) degradation. Here, via scaffold-coating synergistic strategy, composite separator integrating heat-resistant, polar aramid nanofiber (ANF) porous scaffold with ultrasmall hollow covalent triazine framework nanosphere (SCTF) coating is fabricated to boost the cycling performance of LMBs across diverse operating conditions. The highly porous ANF layer serves as robust electrolyte reservoir, while the SCTF layer functions as efficient ion redistributor leveraging its extensive interconnected pathways present within staggered layers of intrinsic nanopores with intra- and interparticle open spaces. To highlight the importance of mesoscale structure of coatings, the ion transport uniformity and kinetics of SCTF/ANF separator are compared with those of nanosheet-like CTF and large hollow CTF nanosphere coated separators by time-of-flight secondary ion mass spectrometry and molecular dynamics simulations. Owing to its exceptional ionic conductivity (1.41 mS cm −1 ) and Li + transference number (0.79), the SCTF/ANF separator endows the Li//LiFePO 4 cell with capacity retention of 72% after 3000 cycles at 5 C. The practical viability of this separator is demonstrated by its stable cycling performances in high-rate, high-voltage, and high-temperature LMBs, along with pouch cells. This work highlights the scaffold-coating synergy and mesoscale coating design of separators for high-performance LMBs.}, archive = {J_ADVS}, author = {Yufei Yang and Kaveesha Ihala Kodippili and Yun Wang and Jintumol Mathew and Jie Chen and Yi Chen and Xingyan Zeng and Xuyang Wang and Xingping Zhou and Petr Král and Hui Nie and Xiaolin Xie}, doi = {10.1002/advs.202510757}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10757}, shortjournal = {Adv. Sci.}, title = {Ultrasmall hollow covalent triazine framework Nanosphere/Aramid nanofiber composite separator for high-energy lithium metal batteries}, volume = {12}, year = {2025}, }
• (2025). Dynamic mosaicity modulates ion transport in stimuli-responsive liquid crystal electrolytes. ADVS, 12(41), e10610. (www)

  @article{ , abstract = {Structural mosaicity and defects are ubiquitous across materials and critically influence functional properties, from semiconductors to biological membranes. In soft matter electrolytes, these features remain difficult to probe and exploit due to complex synthesis and limited long-range structural order. A dimensionally tunable model system based on thermotropic ionic liquid crystals (TILCs) is introduced to investigate the interplay between structural mosaicity and ion transport. In two-dimensional (2D) anion-conducting smectic TILCs, ion transport exhibits a pronounced anisotropy—up to four orders of magnitude at 70 °C—attributed to ion confinement within 0.7–1.2 nm-thick lamellar sublayers. In situ and operando synchrotron X-ray scattering combined with electrochemical analyses reveal direct experimental evidence of a strong correlation between long-range supramolecular organization, quantified via dynamic mosaicity, and mesoscopic ion transport. Application of a 1 Tesla magnetic field enhances domain size by 1.5× and boosts conductivity threefold, demonstrating stimuli-responsive, mosaicity-controlled ionic transport. These findings establish a generalizable structure–function framework for confined ion conduction in soft materials and bridge concepts from thermotropic liquid crystals to lyotropic phases, biological assemblies, and organic semiconductors. Positioning dynamic mosaicity as a key design parameter, this work lays the foundation for rational development of adaptive, self-organized electrolyte systems for energy storage and conversion, ionotronics, and bioinspired ionic devices.}, archive = {J_ADVS}, author = {Hélène Pung and Celso Yassuo Okada-Junior and Mirella Simões Santos and Marta Mirolo and Isabelle Morfin and Gilbert Chahine and Jannick Duchet-Rumeau and Johan Jacquemin and Agilio Padua and Sébastien Livi and Patrice Rannou and Manuel Maréchal}, doi = {10.1002/advs.202510610}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10610}, shortjournal = {Adv. Sci.}, title = {Dynamic mosaicity modulates ion transport in stimuli-responsive liquid crystal electrolytes}, volume = {12}, year = {2025}, }
• (2025). LRRC8A regulates outer hair cell volume and electromotility and is required for hearing. ADVS, 12(41), e10477. (www)

  @article{ , abstract = {Damage to the cochlear outer hair cell (OHC) is a major cause of deafness in mammals. OHCs amplify the auditory signals to enhance the sensitivity and sound frequency selectivity of the auditory system. However, detailed mechanisms underlying functional OHC regulation remain unclear. Here, it is demonstrated that volume-regulated anion channels (VRACs) are essential for OHC function. VRAC subunits are highly expressed in OHCs. Genetic deletion of leucin-rich repeat containing 8A (LRRC8A), the obligatory VRAC subunit, in hair cells results in hearing loss, whereas re-expressing LRRC8A in the cochlea restores hearing in LRRC8A-deficient mice. By employing patch-clamp electrophysiology, it is shown that VRAC in OHCs is activated by hypotonicity and is involved in regulating cell volume. Furthermore, the nonlinear capacitance (NLC), a measure of electromotility, is decreased in the OHCs from LRRC8A-deficient mice. Therefore, LRRC8A deficiency compromises electromotility of OHCs and impairs signal amplification. In conclusion, the findings highlight the essential role of VRAC in OHC electromotility and its necessity for auditory function.}, archive = {J_ADVS}, author = {Shengnan Wang and Yuehui Xi and Qiaojun Fang and Sai Shi and Fei Wang and Fuyu Xian and Zhongyang Zhang and Yuxin Yang and Xishuo Jin and Xiaomin Wang and Chen Cao and Hailin Zhang and Nikita Gamper and Zhigang Xu and Haitao Shen and Ping Lv}, doi = {10.1002/advs.202410477}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10477}, shortjournal = {Adv. Sci.}, title = {LRRC8A regulates outer hair cell volume and electromotility and is required for hearing}, volume = {12}, year = {2025}, }
• (2025). SPARC: A soft, proprioceptive, agile robot for 3D climbing and exploration with precise trajectory following. ADVS, 12(41), e10382. (www)

  @article{ , abstract = {Soft robots, like their natural counterparts, are well-suited for exploring 3D terrains due to their large deformation, impact resistance, and adaptive adhesion, derived from their inherent compliance. However, developing soft robots that can navigate both horizontal and vertical surfaces with seamless transitions and precise trajectory tracking remains a challenge. SPARC, a Soft, Proprioceptive, Agile Robot is presented for 3D climbing and exploration with accurate trajectory following. SPARC integrates three parallel 3D-printed Kresling origami actuators with suction cups for 3D actuation and adhesion across diverse surfaces. Leveraging the contraction–twisting coupling of Kresling structures, SPARC enables real-time proprioception through inverse kinematics modeling. A dual closed-loop control strategy combined with efficient online path planning allows precise pose control using onboard angle sensors and global position tracking. Experiments demonstrate SPARC's ability to follow curved and sharply angled trajectories with high precision'achieving 0.5% accuracy on horizontal and 3% on vertical surfaces'while carrying payloads exceeding twice its weight (500 g) on vertical climbs. Moreover, connecting two SPARC modules enables smooth ground-to-wall transitions. The seamless integration of large-magnitude 3D actuation, proprioceptive state sensing, and efficient online path planning makes SPARC a unique soft robot capable of precise trajectory following and navigation in 3D terrains.}, archive = {J_ADVS}, author = {Weicheng Fan and Jiaqi Wang and Hongjian Zhang and Qichen Wu and Qihong Hu and Genliang Chen and Hao Wang and Xiaonan Huang}, doi = {10.1002/advs.202510382}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10382}, shortjournal = {Adv. Sci.}, title = {SPARC: A soft, proprioceptive, agile robot for 3D climbing and exploration with precise trajectory following}, volume = {12}, year = {2025}, }
• (2025). A single-component adhesive sponge based on blood-triggered and autopenetrative adhesion for robust vascular closure. ADVS, 12(41), e10377. (www)

  @article{ , abstract = {Achieving strong adhesion under wet and bleeding conditions remains a major challenge for medical adhesives. Existing strategies that utilize polymer chain penetration to overcome this have shown promise but typically rely on complex external stimuli, limiting clinical use. Here, MonoSeal is introduced, a body-fluid-triggered adhesive sponge composed of a single oxidized polysaccharide, operating via a newly proposed mechanism termed Autopenetrative Adhesion (APA). Unlike conventional approaches, APA enables spontaneous polymer chain penetration into moist tissues via concentration-gradient-driven diffusion, without any external activation. This self-driven penetration dramatically increases the interfacial density and depth of reactive groups, which then form covalent bonds with tissue amines, establishing strong tissue anchoring. Meanwhile, the proteins present in body fluids serve to cross-link the sponge matrix, forming a rapid in situ barrier that mechanically seals the wound. By tailoring the molecular weight and sponge architecture, the dissolution–cross-linking kinetics is fine-tuned to optimize adhesive penetration and mechanical sealing. The resulting MonoSeal achieved robust tissue adhesion and effectively sealed the 12 Fr puncture wound on the porcine femoral artery within 30 s. When delivered via a customized applicator, MonoSeal also demonstrates promising performance as a vascular closure device following interventional access in the porcine carotid artery.}, archive = {J_ADVS}, author = {Rong Wang and Weishi Zheng and Yuxuan Huang and Rui Zhang and Yi Zhang and Jingying Yan and Yuqing Gu and Jingyun Xi and Tun Yuan and Hua Su and Xianzhu Zhang and Xiaozhao Wang and Shaohui Xiong and Zhenfeng Cheng and Hongwei Ouyang and Yi Hong}, doi = {10.1002/advs.202510377}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10377}, shortjournal = {Adv. Sci.}, title = {A single-component adhesive sponge based on blood-triggered and autopenetrative adhesion for robust vascular closure}, volume = {12}, year = {2025}, }
• (2025). Efficient noncollinear second-harmonic generation in Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 crystals through domain-engineering. ADVS, 12(41), e10153. (www)

  @article{ , abstract = {Achieving broadband and effective frequency conversion through non-collinear phase matching (PM) is of significant interest due to its potential applications in all-optical signal processing. To overcome the stringent requirements of the quasi-phase-matching condition, such as the period width, polarization, and incident direction, perovskite-type ferroelectric materials with natural ferroelectric domains offer advantages for achieving broadband second-harmonic generation (SHG). However, the random distribution of lattice vectors and scattering at domain walls not only causes substantial scattering losses, limiting conversion efficiency, but also complicates detection and application. In this study, we present a new type of nonlinear photonic crystal by constructing a domain structure with a regular distribution of polarization vectors in a Pb(In 1/2 Nb 1/2 )O 3 -Pb(Mg 1/3 Nb 2/3 )O 3 -PbTiO 3 (PIN-PMN-PT) crystal. This structure enables SHG with increased efficiency (6 × 10 −5 ) at fundamental wavelengths ranging from 1064 to 1340 nm without the need for angle or temperature tuning. Additionally, this unique domain structure facilitates the spontaneous deviation of the SHG emission direction from the propagation direction of fundamental-frequency light (FL), thus eliminating detection and application challenges. This work presents a new method of achieving broadband and efficient noncollinear SHG using domain engineering, and also pushes the boundaries of frequency conversion techniques in ferroelectrics.}, archive = {J_ADVS}, author = {Xin Liu and Wenxu Huang and Kexin Song and Haisheng Guo and Weigang Zhao and Fusheng Qiu and Zhuo Xu and Fei Li and Xiaoyong Wei}, doi = {10.1002/advs.202510153}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10153}, shortjournal = {Adv. Sci.}, title = {Efficient noncollinear second-harmonic generation in Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 crystals through domain-engineering}, volume = {12}, year = {2025}, }
• (2025). A sensitive ratiometric thermometer constructed by AIEgen-based mixed lanthanide MOF for intracellular temperature mapping. ADVS, 12(41), e10147. (www)

  @article{ , abstract = {Accurate temperature sensing at the subcellular level is of great significance for gaining insights into a wide range of biological processes. Aggregation-induced emission (AIE) is a promising photophysical phenomenon in which the luminescence intensity is highly related to the degree of restriction of intramolecular motions. By combining AIE luminogen (AIEgen) ligands with mixed lanthanide ions, an AIEgen-based mixed lanthanide MOF (LnMOF) can be synthesized. In this unique MOF matrix, the vibrations of pendant phenyl rings in the AIEgen ligands are particularly sensitive to temperature changes, rendering the mixed LnMOF highly sensitive as a ratiometric thermometer. Within the physiological temperature range (291–321 K), the maximum relative sensitivity (S m ) is ≈7.32% K −1 at 321 K, demonstrating superior performance compared to reported ratiometric luminescent MOFs. With the aim of detecting intracellular temperature, the mixed LnMOF at the nanoscale is synthesized and further modified, enabling the visual detection of intracellular temperature in L929 cells and HeLa cells. This work demonstrates the first example that MOF-based ratio thermometers can be practically used in living cells.}, archive = {J_ADVS}, author = {Zhijia Li and Jieping Zhang and Zhiyuan Wu and Hang Lei and Yunfang Zhao and Wenqiu Qi and Xue Gao and Feilong Jiang and Yongsheng Liu and Lian Chen and Maochun Hong}, doi = {10.1002/advs.202510147}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10147}, shortjournal = {Adv. Sci.}, title = {A sensitive ratiometric thermometer constructed by AIEgen-based mixed lanthanide MOF for intracellular temperature mapping}, volume = {12}, year = {2025}, }
• (2025). Magnetized cell-scaffold constructs for bone tissue engineering: Advances in fabrication and magnetic stimulation. ADVS, 12(41), e10094. (www)

  @article{ , abstract = {Magnetic particles (MPs), due to their unique physical and chemical properties, have emerged as promising tools in bone tissue engineering. Their incorporation into scaffolds or uptake by bone cells, combined with exposure to external magnetic fields, has been shown in various studies to enhance cell adhesion, proliferation, and osteogenic differentiation. In this review, the state-of-the-art is presented on the synthesis processes of magnetized cells (MCs) and magnetized scaffolds (MSs), as well as the biological and mechanical effects of scaffold-free MCs, cell-seeded MSs, and MC-seeded MSs under externally applied magnetic fields on bone tissue engineering. Furthermore, the specific applications of these systems is highlighted, such as non-contact mechanical stimulation, and discuss their application to advance bone tissue engineering strategies.}, archive = {J_ADVS}, author = {Elio Cinar SanSegundo and Mohammad J. Mirzaali and Lidy E. Fratila-Apachitei and Amir A. Zadpoor}, doi = {10.1002/advs.202510094}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10094}, shortjournal = {Adv. Sci.}, title = {Magnetized cell-scaffold constructs for bone tissue engineering: Advances in fabrication and magnetic stimulation}, volume = {12}, year = {2025}, }
• (2025). Learning to navigate in chemical fields without a map at low reynolds numbers. ADVS, 12(41), e10092. (www)

  @article{ , abstract = {Effective navigation of microswimmers relies on their ability to search for unknown target locations using limited information provided by local environmental cues. Biological microswimmers have evolved versatile strategies to achieve such mapless navigation. Yet, achieving autonomous navigation in artificial microswimmers, comparable to that of their biological counterparts, remains a significant challenge. In this work, deep reinforcement learning is employed to equip a reconfigurable artificial microswimmer with the ability to navigate and search for a target without relying on a pre-existing map. These results demonstrate how this mapless swimmer can effectively navigate toward a chemical source by responding to local chemical signals. Remarkably, the swimmer adapts its locomotory gaits in response to local chemical fields, exhibiting a run-and-tumble strategy reminiscent of bacterial chemotaxis. Unlike map-based swimmers, which depend on pre-existing maps for successful navigation, the mapless swimmer achieves robust performance even in chemical fields that significantly deviate from its training environment, including time-varying fluctuating environment. Moreover, the swimmer can progressively explore complex chemical fields with multiple local maxima, effectively searching for regions of higher concentration. These findings present a promising approach toward achieving autonomous navigation for artificial microswimmers in unknown environments.}, archive = {J_ADVS}, author = {Yangzhe Liu and On Shun Pak and Alan C. H. Tsang}, doi = {10.1002/advs.202510092}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10092}, shortjournal = {Adv. Sci.}, title = {Learning to navigate in chemical fields without a map at low reynolds numbers}, volume = {12}, year = {2025}, }
• (2025). Retromer regulates macro- and micro-autophagy via distinct vacuolar proteases in the rice blast fungus. ADVS, 12(41), e10068. (www)

  @article{ , abstract = {The vacuole degrades and recycles endocytic and autophagic cargos, while the retromer complex sorts cargos from the endosomes to the trans-Golgi network or the plasma membrane, thus preventing unnecessary vacuolar degradation. However, whether the retromer complex regulates vacuolar proteolytic system during autophagic substrate degradation remains unclear. This study demonstrates that the retromer complex regulates both general and selective autophagy by ensuring the delivery of vacuolar protease(s) into the vacuole lumen in the rice blast fungus Magnaporthe oryzae . The central retromer subunit, MoVps35, transports the serine protease MoPrb1 from the endosomes to the vacuole lumen. Deletion of MoVPS35 or any other retromer component prevents the transport of MoPrb1-GFP into the vacuole lumen. Consistently, Δ Moprb1 mutant shows similar defects as the retromer mutants, including failure of autophagy-dependent conidiation and plant infection. Additionally, mutation of the catalytic residues of MoPrb1 (Asp 192, His 224 and Ser 390) reduces autophagy flux. Furthermore, MoVps35 also interacts with another aspartyl protease MoPep4 via MoPrb1. Loss of MoPEP4 leads to abnormal micro-autophagy (pexophagy) but not to fungal development and pathogenicity. Overall, this study demonstrates a crucial role of the retromer complex in the regulation of macro- and micro-autophagy by different vacuolar proteases in M. oryzae .}, archive = {J_ADVS}, author = {Dingyang Zhang and Jiexiong Hu and Yonghe Hong and Yuping Fan and Minghui Peng and Yakubu Saddeeq Abubakar and Shujing Liang and Nan Jiang and Lili Lin and Xiaohong Pan and Huakun Zheng and Naweed I. Naqvi and Zonghua Wang and Wenhui Zheng}, doi = {10.1002/advs.202510068}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10068}, shortjournal = {Adv. Sci.}, title = {Retromer regulates macro- and micro-autophagy via distinct vacuolar proteases in the rice blast fungus}, volume = {12}, year = {2025}, }
• (2025). Liquid metal printed zinc tin composite oxide nanosheets: A platform for multifunctional sensing at room temperature. ADVS, 12(41), e10017. (www)

  @article{ , abstract = {Liquid metal (LM) alloys have attracted significant interest as exceptional functional materials due to their wide range of applications. Although significant theoretical advancements have been made, the experimental investigation of surface oxides in complex metal alloys remains largely unexplored. This study investigates the formation of surface oxide in eutectic zinc (Zn)–tin (Sn) alloy to increase the understanding of composite metal oxides and enable new technological applications. The study reveals the formation of zinc tin composite metal oxide (ZTCMO) with ≈82.7 at% ZnO and ≈17.3 at% SnO 2 by utilizing the liquid metal-based van der Waals (vdW) printing approach. Structural characterizations confirm the formation of highly crystalline ZTCMO nanosheets with a wide bandgap of 3.3 eV. The ultrathin nanosheets demonstrate their practicality as an ultraviolet (UV) optical sensor with maximum responsivities of 3.84 A W −1 at 285 nm and 1.31 A W −1 at 365 nm, achieved at a low power density of 0.1 mW cm −2 . Additionally, ZTCMO nanosheets exhibit excellent room temperature ammonia (NH 3 ) gas sensing with high sensitivity and selectivity, detecting concentrations as low as 50 parts per million under UV light illumination. These findings highlight the potential of composite metal oxide-based devices with the capability of multifunctional sensing.}, archive = {J_ADVS}, author = {Vaishnavi Krishnamurthi and Hamidah Alluhaybi and Pargam Vashishtha and Xiangyang Guo and Huy Hoang Nguyen and Javad Khosravi Farsani and Ali Zavabeti and Sindhu Priya Giridhar and Azmira Jannat and Shimul Kanti Nath and Aaron Elbourne and Sumeet Walia and Torben Daeneke and Ylias Sabri and Chung Kim Nguyen and Nitu Syed}, doi = {10.1002/advs.202510017}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e10017}, shortjournal = {Adv. Sci.}, title = {Liquid metal printed zinc tin composite oxide nanosheets: A platform for multifunctional sensing at room temperature}, volume = {12}, year = {2025}, }
• (2025). Regulation of microstructure and absorption properties of MXene materials: Theoretical and experimental. ADVS, 12(41), e09994. (www)

  @article{ , abstract = {This study systematically investigates the modulation mechanism of transition metal elements (Ti, Nb, Ta, V) on the microwave absorption performance of MXenes (Ti 3 C 2 T x , Ti 2 NbC 2 Tx, Ti 2 TaC 2 T x , Ti 2 VC 2 T x , Nb 2 CT x , V 2 CT x ). Using multiscale characterization techniques, the microstructure, elemental distribution, and surface chemical states of these materials are comprehensively analyzed. Integrated electromagnetic parameter measurements and theoretical calculations elucidate the physical mechanisms underlying their distinct microwave absorption behaviors. Experimental results reveal that the single-metal V-based MXene V 2 CT x exhibits outstanding X-band (8.2–12.4 GHz) absorption performance, achieving an ultralow RL of −53.8 dB and a broad effective absorption bandwidth of 3.4 GHz. Theoretical calculations indicate that V's multivalent d-orbitals generate pronounced density of states (DOS) peaks near the Fermi level, significantly enhancing carrier mobility and wave-carrier interactions. Normalized impedance analysis confirms excellent impedance matching with free space, a critical factor for minimizing microwave reflection and maximizing energy dissipation. In contrast, Ti-, Nb-, and Ta-based MXenes show limited performance, primarily relying on single loss mechanisms that fail to balance impedance and dissipation efficiently. The findings provide theoretical guidance for designing high-performance broadband microwave absorbers by tailoring atomic-scale composition to optimize impedance matching and multi-mechanistic energy dissipation in MXene-based materials.}, archive = {J_ADVS}, author = {Qiang Wang and Xiaolei Su and Yan Jia and Yi Liu and Faisal Shahzad}, doi = {10.1002/advs.202509994}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09994}, shortjournal = {Adv. Sci.}, title = {Regulation of microstructure and absorption properties of MXene materials: Theoretical and experimental}, volume = {12}, year = {2025}, }
• (2025). Treating hearing loss: From cochlear implantation to gene therapy. ADVS, 12(41), e09960. (www)

  @article{ , abstract = {Gene therapy has recently restored natural audibility in humans with OTOF-gene mutations. This biological restoration of hearing is different from cochlear implantation (CI) that produces artificial hearing via electric stimulation of the auditory nerve. In three published trials, 21 DFNB9 patients show 244 grade I/II adverse events (AEs), 2 grade III AEs and no serious AEs. The average gene therapy effect is substantial (52.4-dB improvement from baseline complete deafness), rapid (0.74-month time constant), and stable over the initial six months. However, individual outcomes vary from restored normal audibility (≤20 dB HL) to severe hearing loss (≥80 dB HL). Here critical knowledge gaps in gene therapy are identified such as understanding the individual variability, assessing temporal processing, and comparing efficacy with cochlear implantation. It is predicted that gene therapy will include patients with less than complete hearing loss and target other monogenic forms of congenital deafness. Advanced technologies in minimally invasive drug delivery and gene editing will further increase the safety, efficacy and applicability of gene therapy for hearing loss. Cochlear implantation likely remains the standard intervention for severe-to-profound hearing loss, but gene therapy will emerge as a viable alternative in treating monogenic forms of deafness.}, archive = {J_ADVS}, author = {Fan-Gang Zeng and Jieyu Qi and Chen-Chi Wu and Yilai Shu and Renjie Chai}, doi = {10.1002/advs.202509960}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09960}, shortjournal = {Adv. Sci.}, title = {Treating hearing loss: From cochlear implantation to gene therapy}, volume = {12}, year = {2025}, }
• (2025). From knitting technology to robotics: Untethered thermally actuated textile exoskeleton for dexterity applications. ADVS, 12(41), e09870. (www)

  @article{ , abstract = {Soft wearable robotic devices offer significant potential for human mobility assistance and rehabilitation; however, existing solutions are often hindered by bulkiness, limited scalability, and restricted portability. This study introduces a textile-based exoskeleton glove equipped with thermally driven actuators, achieving dexterous motion in under 12 s using only 10.8 W of power while maintaining a low operating temperature of 48 °C. This performance surpasses the fastest previously reported system in terms of power input and operating temperature, which achieved actuation in 10 s but required 15 W and operated at 100 °C. In comparison, recent studies report response times of 120 s, with 14 W consumption and temperatures near 95 °C. The actuators utilize low-boiling-point liquids that undergo phase transitions upon heating, enabling fast, untethered actuation without external systems. The seamless knitted structure integrates sensing and actuation functionalities, including self-return to initial position capability. This is achieved through digital machine knitting of specific patterns using functional yarns. The actuators demonstrate 270° bending, generating 2 N gripping force while maintaining energy consumption efficiency. The glove is mountable on an industrial robotic arm, demonstrating its ability to grasp and relocate objects. This study presents a quick-response, scalable, energy-efficient solution for wearable robotics.}, archive = {J_ADVS}, author = {Ibrahim Adel Khamis Ahmed and Munire Sibel Cetin and Kadir Ozlem and Asli Tuncay Atalay and Gökhan Ince and Ozgur Atalay}, doi = {10.1002/advs.202509870}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09870}, shortjournal = {Adv. Sci.}, title = {From knitting technology to robotics: Untethered thermally actuated textile exoskeleton for dexterity applications}, volume = {12}, year = {2025}, }
• (2025). Hypoxia-induced PRMT1 lactylation drives vimentin arginine asymmetric dimethylation in tumor metastasis. ADVS, 12(41), e09861. (www)

  @article{ , abstract = {Metastasis contributes to around 90% of cancer mortality, but effective strategies to disrupt metastatic cascades remain elusive. Hypoxia-driven epithelial-mesenchymal transition (EMT) promotes cancer cell spread, yet the post-translational mechanisms governing cytoskeletal reprogramming here remain incompletely defined. This study reports a hypoxia-inducible post-translational modification cascade: under hypoxia, protein arginine methyltransferase 1 (PRMT1) is lactylated at evolutionarily conserved residues K134/K145, enhancing its methyltransferase activity to catalyze the asymmetric dimethylation (aDMA) of vimentin at R64. This modification drives vimentin filament assembly, cytoskeletal remodeling, and metastasis in preclinical models. shPRMT1 or vimentin R64K mutation (methylation-deficient) abrogates hypoxia-enhanced migration in vitro and metastasis in vivo. Hypoxia reduces the protein levels of HDAC8 (PRMT1’s delactylase), boosting PRMT1 lactylation. PRMT1 K134R/K145R mutants (lactylation - deficient) lose the ability to bind vimentin and fail to rescue filament formation. In triple-negative breast cancer (TNBC), vimentin R64 aDMA levels correlate with advanced tumor stage and poor patient survival. PRMT1 inhibitor MS023 reduces xenograft metastasis with low toxicity. These findings establish a hypoxia-PRMT1-vimentin axis, identifying vimentin R64 aDMA as a metastatic regulator. Inhibiting PRMT1 represents a promising anti-metastasis strategy.}, archive = {J_ADVS}, author = {Jia Zhou and Shuying Qiu and Xia Yang and Yan Wu and Xinxia Yao and Hangqi Hu and Jingfeng Luo and Chandra Sugiarto Wijaya and Lingfeng Ma and Xiaojun Long and Lingna Xu and Jinquan Liu and Chaoqun Wang and Yibin Pan and Xiaona Chen and Hongchuan Jin and Xian Wang}, doi = {10.1002/advs.202509861}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09861}, shortjournal = {Adv. Sci.}, title = {Hypoxia-induced PRMT1 lactylation drives vimentin arginine asymmetric dimethylation in tumor metastasis}, volume = {12}, year = {2025}, }
• (2025). Polycystin-1 mutant alters mechanotransduction in response to collagen and extracellular matrix stiffness via daam1-dependent microfilament remodeling. ADVS, 12(41), e09846. (www)

  @article{ , abstract = {Extracellular matrix (ECM) stiffness-mediated mechanotransduction is a common signaling scheme in both physiological and pathological contexts; however, its molecular mechanisms remain incompletely understood. Polycystin-1 is a transmembrane protein that is known to participate in mechano-transduction. Here, it is demonstrated that, in response to extracellular collagen and increased ECM stiffness, polycystin-1 interacts with disheveled-associated activator of morphogenesis 1 (Daam1), a cytoskeletal regulator, thereby promoting microfilament remodeling, cellular protrusion formation, and enhanced motility of tumor cells through activating the RhoA signaling axis. Wild-type polycystin-1 is susceptible to proteolytic cleavage at the G protein-coupled receptor proteolysis site. Using atomic force microscopy-based single-molecule force spectroscopy, direct evidence is provided that polycystin-1 variants R3039H and L3048H exhibit reduced cleavage susceptibility in vitro. Notably, R3039H is associated with lymphatic and distant metastasis in breast cancer and augments mechanotransduction by facilitating the nuclear translocation of Yes-associated protein and upregulating the expression of connective tissue growth factor and collagen in tumor cells and cancer-associated fibroblasts, respectively. Collectively, our findings identify polycystin-1 as a mechanosensor of collagen and ECM stiffness that modulates tumor cell migration via the Daam1/RhoA/YAP signaling cascade.}, archive = {J_ADVS}, author = {Jiaofeng Zhou and Yibing Deng and Jie Mei and Mengyun Wan and Ningyi Xue and Xinyu Zong and Ji Zhou and Junli Ding and Ting Yan and Yu Jiang and Tiansong Xia and Peng Zheng and Yichao Zhu}, doi = {10.1002/advs.202509846}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09846}, shortjournal = {Adv. Sci.}, title = {Polycystin-1 mutant alters mechanotransduction in response to collagen and extracellular matrix stiffness via daam1-dependent microfilament remodeling}, volume = {12}, year = {2025}, }
• (2025). A kinematically bifurcated metamaterial for integrated logic operation and computing. ADVS, 12(41), e09829. (www)

  @article{ , abstract = {Mechanical computing metamaterials, which utilize transitions among discrete configurations to process information autonomously when perceiving external stimuli, are important in the development of intelligent mechanical systems. However, most current designs involve tessellations of planar mechanisms or bistable structures, which typically offer only two distinct configurations, requiring many units to provide multiple input-outputs for complex logic operations with little consideration of system integration. Here, We propose a family of 2 n -side kinematic polygonal modules introducing n decoupled inputs and 2 n transitable extreme configurations, which are coupled with electrical circuits to construct conductive logic metamaterials for mechanical computing. To simplify the construction of logic computing systems, a minimized combinatorial logic canonical function, the parallel computing sum of the product (PCSoP) function, is developed. We first design and integrate seven basic logic gates on a quadrilateral module, followed by implementing all four types of 2-bit arithmetic operations with a single polygonal module, where the 2-bit divider on an octagonal module is designed for the first time. Moreover, information display and simultaneous recognition of three mathematical properties of the decoded decimal numbers 2-15 are implemented on one polygonal module. This kinematics-based design strategy for mechanical computing metamaterials will greatly advance the development of mechanical intelligence.}, archive = {J_ADVS}, author = {Kaili Xi and Jingsong Wei and Xiao Zhang and Jiayao Ma and Zhong You and Changqing Chen and Yan Chen}, doi = {10.1002/advs.202509829}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09829}, shortjournal = {Adv. Sci.}, title = {A kinematically bifurcated metamaterial for integrated logic operation and computing}, volume = {12}, year = {2025}, }
• (2025). Dual hydrophilic-hydrophobic core architecture in soy glycinin amyloid fibrils revealed by cryo-EM. ADVS, 12(41), e09821. (www)

  @article{ , abstract = {Plant-derived amyloid fibrils represent a promising class of sustainable nanomaterials outperforming their native counterparts in functionalities; however, the atomic-level structural mechanisms behind these enhancements have yet to be elucidated. Using cryo-EM, near-atomic resolution structures (3.4 and 3.5 Å) are determined for two distinct fibril polymorphs assembled in vitro from soy glycinin-A subunit. The dominant Type I fibril exhibits an unprecedented dual-core architecture, characterized by spatially segregated hydrophilic (Asp172-Asn178/Asn178’-Asp172’) and hydrophobic (Val166-Ile168/Val186’-Pro184’) domains, which contribute to a unique amyloid fold distinct from many known amyloid structures, including pathological and functional amyloids. In contrast, the minor Type II fibril adopts a conventional extended hydrophobic core with Tyr155-Tyr158 π-stacking. These atomic structures establish fundamental structure-property relationships that will inform the rational design of plant protein-based nanomaterials.}, archive = {J_ADVS}, author = {Saiya Li and Shuangjian Li and Yijia Cheng and Yapeng Fang and Qin Cao and Yiping Cao}, doi = {10.1002/advs.202509821}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09821}, shortjournal = {Adv. Sci.}, title = {Dual hydrophilic-hydrophobic core architecture in soy glycinin amyloid fibrils revealed by cryo-EM}, volume = {12}, year = {2025}, }
• (2025). Bio-inspired SA-FA bionic dual receptor electronic skin for intelligent gesture and material cognition systems enhanced by static-dynamic mutual interaction. ADVS, 12(41), e09740. (www)

  @article{ , abstract = {Traditional electronic skins (e-skins) face significant challenges in system integration and practical usability demonstrations, limiting their ability to meet the development demands of robot intellectualization under future artificial intelligence (AI) frameworks. Here, a bionic dual receptor (BDR) e-skin motivated by AI-based hardware-software coordination is proposed, which consists of electrospinning fiber triboelectric unit inspired by fast-adapting receptors and micropyramid ionic hydrogel iontronic unit inspired by slow-adapting receptors. Benefiting from the iontronic effect and micropyramid structure, the iontronic unit yields impressive features: a linear sensitivity of 172 kPa −1 (30 kPa), a fast response/recovery time of 11.2 ms. Based on this innovation, the BDR e-skin is integrated into the glove, and a dual-channel signal-motivated intelligent glove cognitive system for sign language gesture identification and robot interaction is developed, laying the foundation for subsequent usability demonstrations. Further, the BDR e-skin is deeply integrated with intelligent software algorithms and high-speed hardware circuits to construct an intelligent autonomous material cognition system. This system enables the robot finger controlled by the intelligent glove to accurately identify multidimensional properties (average accuracy: 99.3%) of smooth surface films—such as electronegativity, softness/hardness, and material species—with a single touch, showing a tactile cognition level comparable to that of humans.}, archive = {J_ADVS}, author = {Hao Li and Hongsen Niu and Hao Kan and Eun-Seong Kim and Nam-Young Kim and Yang Li}, doi = {10.1002/advs.202509740}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09740}, shortjournal = {Adv. Sci.}, title = {Bio-inspired SA-FA bionic dual receptor electronic skin for intelligent gesture and material cognition systems enhanced by static-dynamic mutual interaction}, volume = {12}, year = {2025}, }
• (2025). Globotriaosylceramide gb3 influences wound healing and scar formation by orchestrating fibroblast heterogeneity. ADVS, 12(41), e09733. (www)

  @article{ , abstract = {Cutaneous fibroblast heterogeneity is mechanistically linked to wound repair outcomes and fibrotic progression, with glycosphingolipid metabolism emerging as a critical determinant of physiological fibroblast diversity. Through integrative analysis of spatiotemporal omics, lipidomics, and single-cell RNA sequencing (scRNA-seq) coupled with histological evaluation of clinical specimens, the functional involvement of globotriaosylceramide (Gb3) in dermal regeneration processes is systematically investigated. Comparative profiling reveals significant upregulation of Gb3 biosynthesis in superficial second-degree burns (SSDB) relative to deep second-degree burn (DSDB) injuries. Hexosaminidase subunit beta (HEXB) is identified as the exclusive differentially expressed Gb3 synthase distinguishing these injury subtypes. Functional validation through in vitro and in vivo models demonstrates that pharmacological suppression of HEXB-mediated Gb3 synthesis exacerbates fibroblast-to-myofibroblast transdifferentiation, attenuated fibroblast growth factor 2 (FGF2) signal transduction, and ultimately potentiated fibrotic scarring. These findings establish a novel HEXB-Gb3-FGF2 regulatory axis governing fibroblast phenotypic plasticity in differential-depth skin injuries, providing mechanistic insights for developing targeted antifibrotic therapies.}, archive = {J_ADVS}, author = {Sujie Xie and Runzhi Huang and Weijin Qian and Xinran Ding and Wei Zhang and Yixu Li and Jianyu Lu and Hanlin Sun and Yifan Liu and Yuntao Yao and Bingnan Lu and Minjuan Wu and Zhaofan Xia and Shizhao Ji}, doi = {10.1002/advs.202509733}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09733}, shortjournal = {Adv. Sci.}, title = {Globotriaosylceramide gb3 influences wound healing and scar formation by orchestrating fibroblast heterogeneity}, volume = {12}, year = {2025}, }
• (2025). Bright light emission from deep energy states. ADVS, 12(41), e09549. (www)

  @article{ , abstract = {Deep energy states, a fundamental concept in semiconductor physics, play a pivotal role in determining the optical performance of semiconductor materials. They are generally regarded as undesirable defects, as they can serve as efficient centers for non-radiative recombination. Thus, the prevailing consensus is that deep energy states must be passivated and mitigated to enhance the optical properties of semiconductors. In this work, however, it is demonstrated that these “ undesirable” deep energy states can be harnessed as “ desirable” states to enable bright light emission. This is achieved by proposing a deep energy state regulation mechanism, termed “surface ionization annealing”, which transforms the randomly and broadly distributed non-radiative deep energy levels into a narrower energy range. This transformation results in a high density of states and band-edge-like absorption originating from deep energy states in sulfur quantum dots. The regulation is realized through precise control of surface charge and surface dangling bonds. Simultaneously, surface ionization annealing eliminates non-radiative deep energy states, significantly enhancing the photoluminescence quantum yield (PLQY) of sulfur quantum dots to 15.6%. Consequently, the simultaneous realization of a high density of states and high PLQY enables bright light emission from deep energy states.}, archive = {J_ADVS}, author = {Lian Xiao and Sihang Liu and Zhan Yu and Yong Yi and Rui Duan and Quanchao Du and Yugang Zhao and Xuehong Zhou and Van Duong Ta and Edwin Kok Lee Yeow and Yi Huang and Zhi-Gang Zheng and Handong Sun}, doi = {10.1002/advs.202509549}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09549}, shortjournal = {Adv. Sci.}, title = {Bright light emission from deep energy states}, volume = {12}, year = {2025}, }
• (2025). An automated micro-immunobeads-based electromagnetic operation system (MEMOs) for blood testing of alzheimer's disease. ADVS, 12(41), e09376. (www)

  @article{ , abstract = {The anticipated rise in the prevalence of Alzheimer's disease (AD) under global demographic shifts necessitates the development of universally accessible screening and diagnostic tools, of which blood tests hold the promise. However, the widespread adoption of blood tests remains impeded by the lack of analytically validated biomarkers and accessible decentralized platforms. Here, the study presents a portable and automated micro-immunobeads-based electromagnetic operation system, termed MEMOs, targeting potential AD blood biomarker exosome-bound Aβ42 (Exo-Aβ42), for automated blood testing of AD. MEMOs integrates a microfluidic exosome-detection biological chip (μ-Exo Biochip) embedded with a magnetic field-responsive assay for detecting Exo-Aβ42 and a microbead operation electromagnetic chip (μ-Bead EMchip) for programmable and addressable actuation, collectively delivering a high level of accurate and automated AD testing. In both animal and clinical samples, the levels of Exo-Aβ42 measured using MEMOs have shown significant correlations with various progressive stages of AD. With the features of cost-effective manufacturing, minimized hands-on time, and an easy operation workflow, MEMOs offers an accessible pathway toward diagnosing and monitoring the progression of AD in decentralized practice.}, archive = {J_ADVS}, author = {Xiaoxue Fan and Xinyu Ye and Jiangrui Xu and Tianjiao Mao and Ruotong Zhang and Xinyuan Zhou and Christina C. K. Au Yeung and Chang Li and Raymond Chuen-Chung Chang and Haisong Lin and Ho Cheung Shum}, doi = {10.1002/advs.202509376}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09376}, shortjournal = {Adv. Sci.}, title = {An automated micro-immunobeads-based electromagnetic operation system (MEMOs) for blood testing of alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Serine grafted silica coated nanoscale zero-valent iron with enhanced fenton-like degradation of mixed organic solvents of tributyl phosphate and n-dodecane. ADVS, 12(41), e09319. (www)

  @article{ , abstract = {As global nuclear energy scales up, the annual output of low-to-medium-level radioactive tributyl phosphate (TBP) and n-dodecane organic solvents from spent fuel processing grows. To address this problem, the serine grafted silica coated nanoscale zero-valent iron (Ser-SiO 2 @nZVI) is synthesized and used as a Fenton-like catalyst. Ser-SiO 2 @nZVI is analyzed through various characterization techniques. The catalytic oxidation performance of Ser-SiO 2 @nZVI in the Fenton-like system is evaluated. The effects of catalyst type, temperature, catalyst dosage, H 2 O 2 concentration and H 2 SO 4 concentration on the degradation of organic solvents are optimized. Nuclear isotope simulation experiments proved that the presence of nuclides do not affect the degradation efficiency, and more than 90% of the nuclides remained in the reaction vessel. Electron spin resonance (ESR) results indicated that the Ser-SiO 2 @nZVI/H 2 O 2 system produced more hydroxyl radicals than the nZVI/H 2 O 2 system. Density functional theory (DFT) calculations further suggested that the catalytic performance of Ser-SiO 2 @nZVI is higher, and the adsorption energy between Ser-SiO 2 @nZVI and TBP/n-dodecane is greater, making it more likely to adsorb organic solvents on the catalyst surface. This research provides a theoretical basis for the modification of iron-based materials and their application in the treatment of low-to-medium radioactive organic solvents.}, archive = {J_ADVS}, author = {Peijie Sun and Haifeng Xu and Lejin Xu}, doi = {10.1002/advs.202509319}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09319}, shortjournal = {Adv. Sci.}, title = {Serine grafted silica coated nanoscale zero-valent iron with enhanced fenton-like degradation of mixed organic solvents of tributyl phosphate and n-dodecane}, volume = {12}, year = {2025}, }
• (2025). Advanced image-guidance and surgical-navigation techniques for real-time visualized surgery. ADVS, 12(41), e09294. (www)

  @article{ , abstract = {Surgical navigation is a rapidly evolving multidisciplinary system that plays a crucial role in precision medicine. Surgical-navigation systems have substantially enhanced modern surgery by improving the precision of resection, reducing invasiveness, and enhancing patient outcomes. However, clinicians, engineers, and professionals in other fields often view this field from their own perspectives, which usually results in a one-sided viewpoint. This article aims to provide a thorough overview of the recent advancements in surgical-navigation systems and categorizes them on the basis of their unique characteristics and applications. Established techniques (e.g., radiography, intraoperative computed tomography [CT], magnetic resonance imaging [MRI], and ultrasound) and emerging technologies (e.g., photoacoustic imaging and near-infrared [NIR]-II imaging) are systematically analyzed, highlighting their underlying mechanisms, methods of use, and respective advantages and disadvantages. Despite substantial progress, the existing navigation systems face challenges, including limited accuracy, high costs, and extensive training requirements for surgeons. Addressing these limitations is crucial for widespread adoption of these technologies. The review emphasizes the need for developing more intelligent, minimally invasive, precise, personalized, and radiation-free navigation solutions. By integrating advanced imaging modalities, machine learning algorithms, and real-time feedback mechanisms, next-generation surgical-navigation systems can further enhance surgical precision and patient safety. By bridging the knowledge gap between clinical practice and engineering innovation, this review not only provides valuable insights for surgeons seeking optimal navigation strategies, but also offers engineers a deeper understanding of clinical application scenarios.}, archive = {J_ADVS}, author = {Xiaoxiao Fan and Xiaolong Liu and Qiming Xia and Guoqiao Chen and Jiaxi Cheng and Zhaoqi Shi and Yifeng Fang and Parikshit Asutosh Khadaroo and Jun Qian and Hui Lin}, doi = {10.1002/advs.202509294}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09294}, shortjournal = {Adv. Sci.}, title = {Advanced image-guidance and surgical-navigation techniques for real-time visualized surgery}, volume = {12}, year = {2025}, }
• (2025). An ultra-selective and humidity-resistant room-temperature-operated NO2 sensor based on black TiO2. ADVS, 12(41), e09293. (www)

  @article{ , abstract = {As a common gas-sensing material, TiO 2 is limited by poor gas selectivity and humidity immunity like many other metal oxides. Here, an ultra-selective and humidity-resistant room temperature-operated NO 2 sensor is developed using black TiO 2 for the first time. Compared with conventional white TiO 2 , black TiO 2 significantly enhances NO 2 selectivity and humidity resistance by enhancing the NO 2 response for ≥10 times while simultaneously suppressing responses to 7 common interfering gases and H 2 O adsorption. A wireless portable equipment is developed that exhibits the capabilities of identifying NO 2 from a mixed atmosphere and recognizing environmental differences in practical scenarios. These improvements and different response types are attributed to the regulation of H 2 O adsorption: H 2 O layers are formed on white TiO 2 , leading to dominant ion-proton conductivity and blocked gas–solid interactions, while H 2 O adsorption is suppressed and hydroxyl groups are formed on black TiO 2 , enhancing NO 2 response. This study not only promotes a significant advancement and proves the feasibility of using common metal oxides for high-performance NO 2 detection at room temperature in a mixed environment irrespective of ambient humidity, but also offers valuable insights into the sensing mechanisms.}, archive = {J_ADVS}, author = {Xuelan Cheng and Yizheng Liu and Wei Zhong and Shuai Li and Yan Li and Zixi Zhao and Chunlei Zhang and Jidong Shi and Hui Liu and Zonglong Zhu and Fang Xu}, doi = {10.1002/advs.202509293}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09293}, shortjournal = {Adv. Sci.}, title = {An ultra-selective and humidity-resistant room-temperature-operated NO2 sensor based on black TiO2}, volume = {12}, year = {2025}, }
• (2025). Suppressing the Electron–Phonon coupling in 2D perovskite Cs3Sb2I9 for lead-free indoor photovoltaics. ADVS, 12(41), e09281. (www)

  @article{ , abstract = {Antimony-based perovskite-inspired materials (Sb-PIMs) are promising lead-free candidates for indoor photovoltaic application. Cs 3 Sb 2 I 9 , in particular, with a ≈2.0 eV bandgap, is ideal for harvesting indoor white light. However, solution-processed Sb-PIMs preferentially crystallize into thermodynamically stable 0D structures, leading to strong self-trapped exciton (STE) formation, limiting device performance. Although chloride (Cl) doping can induce 2D structural transitions, it enhances Fröhlich electron–phonon coupling (EPC), creating an intrinsic trade-off. Here, we develop an anion-exchange strategy to fabricate phase-pure, Cl-free 2D Cs 3 Sb 2 I 9 films that suppress STE formation while enabling controlled dimensional reconstruction. This approach yields a reduced Huang–Rhys factor (from 30.7 to 21.5) and prolonged STE lifetime (8.60 to 9.19 ps). Density functional theory (DFT) calculations reveal a significant reduction in excited-state octahedral distortion (Δd = 0.898 × 10 −3 for Cs 3 Sb 2 I 9 vs. 5.752 × 10 −3 for Cs 3 Sb 2 I 6 Cl 3 ), confirming intrinsically weaker EPC in Cl-free structures. The device achieves a power conversion efficiency (PCE) of 3.40% under AM 1.5G solar illumination and an 8.2% PCE under 1000 lux white LED conditions. alongside Long-term stability measurement confirms its environmental robustness. These results represent the highest indoor performance reported to date for Sb-based perovskite-inspired solar cells.}, archive = {J_ADVS}, author = {Yixin Guo and Fei Zhao and Chuanjun Zhang and Ping Wu and Jinchun Jiang and Jiahua Tao and Junhao Chu}, doi = {10.1002/advs.202509281}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e09281}, shortjournal = {Adv. Sci.}, title = {Suppressing the Electron–Phonon coupling in 2D perovskite Cs3Sb2I9 for lead-free indoor photovoltaics}, volume = {12}, year = {2025}, }
• (2025). Deficiency of leucine-rich repeat containing g protein-coupled receptor 4 in pancreas reduces β cell mass. ADVS, 12(41), e08858. (www)

  @article{ , abstract = {Although leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) is abundantly expressed in the pancreas, it is currently unknown whether LGR4 impacts pancreatic endocrine cells. Here, a critical role of LGR4 is demonstrated in islet β cell mass using a group of transgenic mice with LGR4 deficiency. Knock-out of Lgr4 in the pancreas and islet β cells significantly reduced islet β cell mass, and subsequently impaired glucose metabolism upon the challenge of a high-fat diet. Deficiency of LGR4 in these mice or in cultured INS-1 cells showed a significant reduction in islet β cell proliferation measured by Ki-67, EdU, and CCK-8 assay. Increase of islet β cell proliferation induced by Rspondin-LGR4 signaling occurred via Wnt-β-catenin- Ccnd1 axis. In addition, the deficiency of LGR4 in islet β cells significantly increased apoptosis. Inhibition of RANKL-RANK signaling by the TRAF-STOP inhibitor significantly attenuated apoptosis of cultured INS-1 cells induced by deficiency of LGR4. Overall, this work shows that deficiency of LGR4 reduces islet β cell mass via suppression of proliferation and concurrent increase of apoptosis. LGR4 in pancreatic islets is thus critical for the control of glucose homeostasis.}, archive = {J_ADVS}, author = {Chao Luo and Yifan Feng and Jiajie Min and Yan Zhao and Ziming Zhu and Lijun Sun and Hao Yin and Yue Yin and Weizhen Zhang}, doi = {10.1002/advs.202508858}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08858}, shortjournal = {Adv. Sci.}, title = {Deficiency of leucine-rich repeat containing g protein-coupled receptor 4 in pancreas reduces β cell mass}, volume = {12}, year = {2025}, }
• (2025). Enhancing the β-oxidation-like pathway for the optimal production of the immunosuppressant mycophenolic acid. ADVS, 12(41), e08826. (www)

  @article{ , abstract = {The recruitment of catabolic β -oxidation enzyme cascades and their reaction logic for natural product biosynthesis remains underexplored, representing a significant opportunity for synthetic biology to engineer novel pathways for structurally unique metabolites. In this study, the first functional reconstitution of the fungal β -oxidative cascade responsible for assembling the immunosuppressant mycophenolic acid (MPA) is reported. Through in vitro enzyme assays, five peroxisomal enzymes are identified that cooperatively mediate two iterative rounds of side-chain cleavage of the biosynthetic precursor MFDHMP-3C and revealed a key oxidative strategy for pharmacophore formation of MPA. These enzymes catalyzed sequential oxidation, dehydrogenation, hydration, reduction, isomerization, and reverse Claisen condensation reactions, mirroring canonical β -oxidation while adapting it for biosynthetic purposes. Furthermore, integrated overexpression of the rate-limiting peroxisomal acyl-CoA oxidase PbACOX323, peroxisomal biogenesis factor PbPex337, and endoplasmic reticulum (ER)-localized oxygenase MpaB’ in Penicillium brevicompactum NRRL864 increased MPA production by 50% (from 0.77 to 1.15 g L −1 ), demonstrating the biotechnological efficacy of pathway optimization. This work establishes the first example of a full β -oxidation-like enzyme cascade in fungal natural product biosynthesis, providing a paradigm for the evolutionary repurposing of catabolic modules to drive synthetic innovation.}, archive = {J_ADVS}, author = {Baoqiang Fan and Yinuo Liu and Lu-ping Chi and Chaofan Yang and Shengying Li and Wei Zhang}, doi = {10.1002/advs.202508826}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08826}, shortjournal = {Adv. Sci.}, title = {Enhancing the β-oxidation-like pathway for the optimal production of the immunosuppressant mycophenolic acid}, volume = {12}, year = {2025}, }
• (2025). Graphitized biochar derived from agricultural wastes enhances methanogenesis via conductivity-driven direct interspecies electron transfer. ADVS, 12(41), e08739. (www)

  @article{ , abstract = {Biochar has emerged as a promising conductor for facilitating direct interspecies electron transfer (DIET) in anaerobic digestion (AD), yet the mechanisms linking its structural features to methanogenic performance remain unclear. Here, how feedstock type and pyrolysis conditions modulate biochar conductivity and consequently shape methanogenic pathways is investigated. Using straw, wood, and nutshell-derived biochars, nutshell biochar pyrolyzed at 550 °C(CC550) is demonstrated to achieve the highest methane yield, enhancing production by 59% compared to the control and outperforming straw and wood-based biochars by 12% and 5% respectively. Graphitization analysis confirms that high electrical conductivity is key to accelerating methanogenesis. Metagenomic profiling reveals that CC550 enriches cellulose-degrading bacteria and DIET-associated taxa, while upregulating genes related to pili and cytochrome c expression, promoting acetoclastic methanogenesis through enhanced electron flow. These findings highlight the role of graphitic biochar as a metabolic modulator in AD and offer insights for engineering carbon materials to optimize bioenergy recovery from organic waste.}, archive = {J_ADVS}, author = {Caiyun Yang and Zhen Liu and Weiguo Liu and Yuxin Qiu and Shuai Zhang and Xinke Zhang and Mengyi Wang and Heng Wu and Hongyi Lyu and Jinzhi Huang and Jia Liu and Yirong Wang and Siying He and Dongze Gu and Xiaohui Guo and Xuanmin Yang and Teng Xie and Heyu Chen and Yiqing Yao}, doi = {10.1002/advs.202508739}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08739}, shortjournal = {Adv. Sci.}, title = {Graphitized biochar derived from agricultural wastes enhances methanogenesis via conductivity-driven direct interspecies electron transfer}, volume = {12}, year = {2025}, }
• (2025). Thermal release characteristics of aeroengine combustor outlet modulated by gliding arc plasma. ADVS, 12(41), e08724. (www)

  @article{ , abstract = {A gliding arc plasma (GAP) combustion dome is used to construct a diagnostic platform for the swirl combustor of aeroengines. Thermocouple measurements, particle image velocimetry, and spontaneous emission imaging are employed to measure the outlet temperature field, combustor flow field, and combustion field information. The influence of GAP-assisted combustion on the outlet temperature profile of the combustor is then analyzed. The results demonstrate that gliding arc discharge allows the flame to reside closer to the combustion dome, shifting the combustion reaction zone forward. This combustion zone contains most of the active particles generated by gliding arc discharge, enabling a more complete combustion reaction and better heat release. The forward movement of the combustion reaction zone also provides sufficient space for flames to develop inside the combustor. The thermal and transport effects of gliding arc discharge enhance the aerodynamic effect inside the combustor, improve fuel atomization, broaden the flame development range inside the combustor, and make the combustion reaction more complete. Under various working conditions, the application of GAP-assisted combustion increases combustion efficiency by 10.3%, the outlet temperature of the combustor rises by 141.6°C, the outlet temperature distribution function decreases by 29.56%, and the hot-streak area ratio decreases by 72.6%.}, archive = {J_ADVS}, author = {Lei Zhang and Jinlu Yu and Zhankai Kang and Wenhao Su and Guangxia Chen and Yang Yu}, doi = {10.1002/advs.202508724}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08724}, shortjournal = {Adv. Sci.}, title = {Thermal release characteristics of aeroengine combustor outlet modulated by gliding arc plasma}, volume = {12}, year = {2025}, }
• (2025). Molecular design of difluorinated polyether electrolyte for ultrastable high-voltage all-solid-state lithium metal batteries. ADVS, 12(41), e08721. (www)

  @article{ , abstract = {Solid polymer electrolytes with high interfacial stability are considered among the most promising alternatives for replacing liquid electrolytes in high-voltage lithium (Li) metal batteries. However, their application faces significant challenges, such as random dendrite deposition, interfacial side reactions, and sluggish ion transport, leading to performance degradation and safety hazards. Herein, an inherently stable difluorinated polyether electrolyte (DPE) is proposed that exhibits superior interfacial stability and ion conductivity, enabling the reliable operation of high-voltage all-solid-state Li metal batteries (ASSLMBs). Due to the synergistic electron-withdrawing and ion solvation effects of difluorinated functional groups, DPE shows an improved oxidation voltage of 4.9 V and high Li + conductivity of 2.0 × 10 −4 S cm −1 . The generated LiF-rich electrolyte/electrode interphase further improves the stability of DPEs against both Li metal anode and high-voltage cathode. Consequently, the assembled all-solid-state Li||LFP battery retains 73.17% of its capacity after 700 cycles. The high-voltage all-solid-state Li||LiNi 0.6 Co 0.2 Mn 0.2 O 2 (NCM622) battery remains stable over 300 cycles with a high capacity retention of 76.02%. Moreover, the high-voltage ASSLMB shows negligible capacity degradation during 3000 bending cycles at a small radius curvature of 4.0 mm. This work provides a feasible strategy for designing antioxidant polymer electrolytes for the stable operation of high-voltage Li metal batteries.}, archive = {J_ADVS}, author = {Zhenyao Wei and Yufeng Luo and Yongqiang Yang and Yaxin Tang and Junhua Zhou and Chao Luo and Ruo Wang and Huipeng Zeng and Chaoyang Wang and Xiaoxiong Xu and Yonghong Deng and Zijian Zheng and Jian Chang}, doi = {10.1002/advs.202508721}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08721}, shortjournal = {Adv. Sci.}, title = {Molecular design of difluorinated polyether electrolyte for ultrastable high-voltage all-solid-state lithium metal batteries}, volume = {12}, year = {2025}, }
• (2025). Hydrogen-deuterium exchange mass spectrometry for molecular glue characterization. ADVS, 12(41), e08543. (www)

  @article{ , abstract = {Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions. Yet, the precise mechanisms by which many molecular glues exert their adhesive effects are still not well understood. Native mass spectrometry is an established technique used to monitor the stoichiometry and binding equilibria of molecular glue-induced protein–protein interactions. However, knowledge is lacking on how protein interaction dynamics change upon molecular glue-induced stabilization, and what conformational changes occur that enhance the stability of the resulting protein-protein-glue ternary complex. Here, hydrogen-deuterium exchange mass spectrometry (HDX-MS) is showcased as an analytical tool for molecular glue characterization. Using a broadly applicable molecular glue system involving the eukaryotic regulatory protein 14-3-3, its binding partners, and the molecular glue fusicoccin A, the power of HDX-MS is shown in revealing not only molecular glue binding sites, but also conformational changes upon glue binding that result in differentially stabilized protein-protein complexes. Overall, the HDX-MS approach will become highly envisaged and valuable for the characterization of molecular glues, guiding their optimization toward successful design.}, archive = {J_ADVS}, author = {Danielle F. Kay and Hadeeqa G. Raza and Richard G. Doveston and Aneika C. Leney}, doi = {10.1002/advs.202508543}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08543}, shortjournal = {Adv. Sci.}, title = {Hydrogen-deuterium exchange mass spectrometry for molecular glue characterization}, volume = {12}, year = {2025}, }
• (2025). Ultrahigh seebeck coefficient and power factor in low-temperature fused Ag2Se films via superionic-driven plastic deformation. ADVS, 12(41), e08381. (www)

  @article{ , abstract = {Thermoelectric technologies enable the direct solid-state conversion of heat into electricity, but performance improvement is challenging due to the strong interdependences among parameters. Here, the grain boundary-based energy filtering effect is explored to selectively scatter the low-energy carriers and thus enhance the Seebeck coefficient without degrading other properties. A superionic-induced fluid-like plastic deformation mechanism is utilized to fabricate dense and flexible Ag 2 Se films at a very low temperature (≈150 °C), which not only effectively sinters nanoparticles, but is also sufficiently low to maintain a high density of effective grain boundaries by suppressing excess fusing. The success of this low-temperature fusion process is attributed to the existence of excess Ag atoms, which serve as fusing agents to enhance the plastic deformation and thus facilitate the formation of closely contacted grains. As a result, the grain boundaries between those close-contacted grains boost the energy filtering effect while maintain the high electric conductivity, and therefore the obtained Ag 2 Se films achieve an outstanding Seebeck coefficient of −215 µV K −1 and a high power factor of 2500 µW m −1 K −2 at room temperature, representing a significant advancement in room temperature thermoelectric materials.}, archive = {J_ADVS}, author = {Dezhuang Ji and Baosong Li and Xuan Li and Husam Hashem AlTakrori and Balamurugan Thirumalraj and Moh'd Rezeq and Wesley Cantwell and Lianxi Zheng}, doi = {10.1002/advs.202508381}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08381}, shortjournal = {Adv. Sci.}, title = {Ultrahigh seebeck coefficient and power factor in low-temperature fused Ag2Se films via superionic-driven plastic deformation}, volume = {12}, year = {2025}, }
• (2025). Microphysiological solid tumor models in hydrogel beads for CAR t cell immunotherapy evaluation. ADVS, 12(41), e08267. (www)

  @article{ , abstract = {Micrometastases are challenging to resect surgically and to detect with in vivo imaging. Immunotherapy is highly anticipated to revolutionize their treatment, but its overall efficacy still remains limited for solid tumors. Here, a 3D micrometastases model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Prostate cancer that preferentially metastasizes to, e.g ., liver or bone marrow, is utilized as a model. Hydrogel beads with an elastic modulus matching those of soft organs are used to support long-term culturing, immunostaining, and monitoring of the spheroids. As a biochemical cue, the impact of fibroblast activation protein (FAP), an emerging target in the tumor microenvironment, is investigated on prostate cancer spheroids and on the efficacy of CAR T cell therapy. The multi-spheroid model consists of prostate stem cell antigen (PSCA)-expressing prostate cancer cells and FAP-producing fibrosarcoma cells in varying ratios. The morphological features of the model are compared to clinical histopathology and metastatic murine model samples. Finally, CAR T cell trials demonstrate successful chemoattraction and infiltration through the hydrogel matrix, with a dual-targeting approach against FAP and PSCA antigens showing synergistic efficacy. This research provides invaluable insights for engineering 3D tumor models and modeling therapies targeting small metastatic or residual tumors, suggesting that co-targeting may be a more effective strategy to unlock the tumor microenvironment's suppression.}, archive = {J_ADVS}, author = {Xuan Peng and Željko Janićijević and Liliana R. Loureiro and Lydia Hoffmann and Poh Soo Lee and Isli Cela and Benjamin Kruppke and Alexandra Kegler and Anja Feldmann and Ielizaveta Gorodetska and Anja Madleine Markl and Anna Dubrovska and Anne Kathrin Offermann and Michael Bachmann and Larysa Baraban}, doi = {10.1002/advs.202508267}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08267}, shortjournal = {Adv. Sci.}, title = {Microphysiological solid tumor models in hydrogel beads for CAR t cell immunotherapy evaluation}, volume = {12}, year = {2025}, }
• (2025). STEMDiff: A wavelet-enhanced diffusion model for physics-informed STEM image generation. ADVS, 12(41), e08266. (www)

  @article{ , abstract = {Machine learning has emerged as a powerful tool for analyzing scanning transmission electron microscopy (STEM) images, yet its widespread application remains constrained by the scarcity of annotated training data. While deep generative models offer a promising solution, they typically struggle to reproduce the complex high-frequency components that define experimental STEM images. Here, STEMDiff, a conditional diffusion model that transforms simple binary labels derived from crystal structures into realistic STEM images through a physical information embedding strategy, is proposed. By developing a novel Discrete Wavelet Transform-based skip-connection architecture, the high-frequency bias inherent in diffusion models are addressed, enabling the preservation of experimental noise characteristics. This approach generates images that are quantitatively nearly indistinguishable from experimental data (17 fold improvement over previous methods) while retaining ground truth structural information. Fully convolutional networks trained exclusively on these synthetic images achieve high-precision atomic column detection in experimental STEM images of WSe 2 and graphene, despite the presence of substantial background noise and contamination. This approach effectively eliminates the need for laborious manual annotation, providing a scalable solution to the data bottleneck in STEM image analysis. The principles underlying STEMDiff can extend to other scientific imaging modalities, accelerating advancements in materials design for water treatment.}, archive = {J_ADVS}, author = {Yihui Bao and Xinyi Lu and Yanyan Xia and Zhencheng Ye and Houyang Chen}, doi = {10.1002/advs.202508266}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08266}, shortjournal = {Adv. Sci.}, title = {STEMDiff: A wavelet-enhanced diffusion model for physics-informed STEM image generation}, volume = {12}, year = {2025}, }
• (2025). In vitro monitoring of babesia microti infection dynamics in whole blood microenvironments. ADVS, 12(41), e08185. (www)

  @article{ , abstract = {Babesiosis – a globally emerging tick-borne infectious disease primarily caused by the intraerythrocytic piroplasm parasite, Babesia microti – has traditionally been studied using animal models such as mice. Compared to animal models, microfluidic-based models offer advantages, including direct analysis of human samples (such as patient blood), enhanced assay capacity (including physical/optical access, consistency, and throughput), low costs, and easy adoption. Here, an open microfluidic platform named “µ-Blood” is reported for real-time continuous monitoring B. microti infection dynamics in vitro. Compared to other microfluidic-based models, µ-Blood allows direct examination of infected and uninfected whole blood without preprocessing steps like blood dilution or cell isolation, minimizing observer artifacts and preserving the natural whole blood microenvironment. The system enables extended (72 h) monitoring of infection dynamics, including parasite identification, parasitemia measurement, and parasite–host cell interactions, using label-free phase contrast and fluorescence confocal microscopy. With its open microfluidic configuration, µ-Blood provides an in vitro model for studying blood-borne infection dynamics while maintaining integrity of the whole blood microenvironment.}, archive = {J_ADVS}, author = {Chao Li and Emily G. Bache and Amy L. Apgar and Danielle M. Tufts and Tagbo H. R. Niepa}, doi = {10.1002/advs.202508185}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08185}, shortjournal = {Adv. Sci.}, title = {In vitro monitoring of babesia microti infection dynamics in whole blood microenvironments}, volume = {12}, year = {2025}, }
• (2025). Multifunctional carbon dots for electrochemical capacitors reviewed: Their opportunities and challenges. ADVS, 12(41), e08000. (www)

  @article{ , abstract = {Electrochemical capacitors (ECs) are promising energy storage devices due to their rapid charge/discharge capability. However, they face limitations in energy density, and certain capacitor materials may exhibit poor conductivity and structural instability. Carbon dots (CDs), characterized by their small size, abundant surface functional groups, and controllable properties, show great potential in enhancing the performance of ECs. This review presents the challenges and opportunities associated with multifunctional CDs in ECs. It begins by summarizing the classification and basic working principles of ECs. Next, it discusses in detail the synthesis methods, fundamental physical and chemical properties, and the electrochemical and photoelectrochemical properties of CDs. Subsequently, it explores the application of CDs as electrode additives and electrolyte additives in ECs, highlighting their unique benefits in improving capacitor performance. Additionally, it examines the innovative use of CDs in photo-assisted capacitors, revealing insights into capacitor technology derived from the synergistic effects of light and electrochemical energy storage processes. Finally, the current challenges facing the applications for CD-based ECs are discussed, followed by proposing future research opportunities. This review emphasizes the significant role of multifunctional CDs and their promising potential in advancing EC technology.}, archive = {J_ADVS}, author = {Naiyun Liu and Jingwen Yu and Yaxi Li and Yunliang Liu and Sobia Jabeen and Yuanyuan Cheng and Lei Zhou and Dmitri L. Danilov and Peter H. L. Notten and Haitao Li}, doi = {10.1002/advs.202508000}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e08000}, shortjournal = {Adv. Sci.}, title = {Multifunctional carbon dots for electrochemical capacitors reviewed: Their opportunities and challenges}, volume = {12}, year = {2025}, }
• (2025). Targeting HDAC and PARP enhances STING-dependent antitumor immunity in STING-deficient tumor. ADVS, 12(41), e07904. (www)

  @article{ , abstract = {The stimulator of interferon genes (STING)-mediated innate immune pathway plays an important role in tumor immunosurveillance. STING deficiency in tumors impairs the interferon response; however, the underlying mechanism remains unclear. Here, it is demonstrated that histone deacetylase (HDAC) suppresses STING expression by reducing H3K9 acetylation at the STING promoter. The combined inhibition of HDAC and poly(ADP-ribose) polymerase (PARP) induced STING re-expression and promoted cytosolic DNA accumulation, which further activated the interferon response in STING-deficient tumors. A bifunctional HDAC and PARP inhibitor displayed potent antitumor immunity by reinducing and activating the STING pathway. Mechanistically, the bifunctional HDAC and PARP inhibitor induced “BRCAness,” thereby restoring synthetic lethality, reactivating STING expression, and promoting the infiltration and activation of T cells and dendritic cells in the tumor microenvironment. Notably, STING depletion reversed the antitumor effect. Moreover, dual inhibition of HDAC and PARP significantly enhanced the antitumor immune response to immune checkpoint blockade by inducing adaptive immune memory. These findings underscore dual HDAC and PARP inhibition as a promising therapeutic strategy for overcoming the STING pathway deficiency and augmenting antitumor immunity in cancer.}, archive = {J_ADVS}, author = {Chengzhou Mao and Weiwen Fan and Jiaqi Liu and Fangzhou Yang and Wenkai Li and Lulu Li and Zhichao Shi and Qinyuan Li and Zigao Yuan and Yuyang Jiang and Bizhu Chu}, doi = {10.1002/advs.202507904}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07904}, shortjournal = {Adv. Sci.}, title = {Targeting HDAC and PARP enhances STING-dependent antitumor immunity in STING-deficient tumor}, volume = {12}, year = {2025}, }
• (2025). Next-generation piezoelectric materials in wearable and implantable devices for continuous physiological monitoring. ADVS, 12(41), e07853. (www)

  @article{ , abstract = {The rapid expansion of miniature biomedical devices has attracted considerable global attention, driven by the growing demand for advanced healthcare solutions. Despite significant progress in materials, fabrication techniques, and device architectures that have propelled the development of wearable and implantable technologies, a critical challenge remains: mimicking the structure and function of human skin. This challenge contrasts advancements in power efficiency, design miniaturization, precision, and device integration. Recent breakthroughs in manufacturing techniques and the development of high-performance organic and inorganic piezoelectric materials with tunable mechanical properties offer transformative potential to overcome these limitations. This review systematically examines the evolution of piezoelectric materials for health monitoring applications, focusing on their historical development, underlying mechanisms, fabrication strategies, and characterization techniques. We critically evaluate their integration into wearable and implantable systems, emphasizing their potential to address power autonomy, device adaptability, and sensing accuracy issues. Additionally, the article highlights emerging interdisciplinary research frontiers in bioengineering, highlighting pioneering contributions from global research teams. By synthesizing key advancements and identifying unresolved challenges, this review aims to provide a comprehensive guide for future innovations in smart biomedical devices, fostering collaborative efforts across the materials science, electronics, and healthcare fields.}, archive = {J_ADVS}, author = {Bangul Khan and Umay Amara and Bilawal Khan and Wasim Ullah Khan and Rafi u Shan Ahmad and Muhammad Shehzad Khan and Mohamed Elhousseini Hilal and Bee Luan Khoo}, doi = {10.1002/advs.202507853}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07853}, shortjournal = {Adv. Sci.}, title = {Next-generation piezoelectric materials in wearable and implantable devices for continuous physiological monitoring}, volume = {12}, year = {2025}, }
• (2025). Unveiling exciton-plasmon polariton coupling regions via polarization-enhanced optical nanoscopy. ADVS, 12(41), e07822. (www)

  @article{ , abstract = {Nanoscale accuracy in single-molecule localization is a crucial function in wide-field super-resolution optical microscopy by surpassing the diffraction limit. However, achieving high localization accuracy remains a challenge due to limitations in the signal-to-noise ratio and the complexity of molecular environments. In this study, a novel polarization-enhanced single-molecule localization microscopy (P-SMLM) technique is introduced, incorporating dynamic polarization modulation to enhance the localization accuracy significantly. By modulating the polarization state of the excitation light, the technique leverages molecular sparsity, enabling more precise position determination. A 16 fold improvement in localization accuracy is shown experimentally compared to conventional methods, particularly under low signal-to-noise conditions. Moreover, the P-SMLM enables direct visualization of exciton-plasmon polariton coupling regions at room temperature. This findings highlight the potential of polarization modulation as a versatile tool for advancing single-molecule localization microscopy (SMLM) accuracy and its applicability in diverse scientific and technological fields.}, archive = {J_ADVS}, author = {Bin Chan Joo and Dong Hee Park and Kyu Ri Choi and Yeon Ui Lee}, doi = {10.1002/advs.202507822}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07822}, shortjournal = {Adv. Sci.}, title = {Unveiling exciton-plasmon polariton coupling regions via polarization-enhanced optical nanoscopy}, volume = {12}, year = {2025}, }
• (2025). Vinyl acetate-enhanced polyvinyl chloride gel with high electroadhesion and self-heating-tunability for soft robots in freezing environments. ADVS, 12(41), e07757. (www)

  @article{ , abstract = {Polyvinyl chloride gel (PVCg) exhibits versatile electromechanical properties, making it highly promising for soft robots. However, conventional PVCg with excessive plasticizers generates a significant amount of heat and suffers from premature electrical breakdown during electro-induced actuation, seriously limiting its widespread application. Here, a novel strategy is demonstrated to simultaneously regulate the heat generation and improve the electromechanical properties of PVCg by introducing polyvinyl chloride-co-vinyl acetate (PVCVA) to fabricate PVCVA gel (PVCVAg). Notably, the proposed PVCVAg exhibits over 50% reduction in heat generation, 15-fold extended lifespan (from 200 s to over 3000 s), and 2.15 times higher electro-adhesion force (from 13.8 to 29.6 kPa) compared to the state-of-the-art PVCg. Based on the improved electroactive properties of PVCVAg, electro-actuation, adhesion, and tunable heating are integrated into a soft robot to achieve fast crawling, module self-reconfiguration within millimeter dimensions via electroadhesive connections, and on-demand environmental thermal interaction without requiring auxiliary heaters. Moreover, these capabilities are validated through various tests, including self-reconfiguration in maze-like confined spaces, operation at −50 °C, and collaborative aero-engine blisk inspection and ice melting in freezing environments. These demonstrations highlight the application potential of the integrated multifunctional PVCVAg devices in complex and extreme environments.}, archive = {J_ADVS}, author = {Chang Wei and Junshi Zhang and Lei Liu and Han Yan and Kaijun Wang and Yuzheng He and Minchao Cui and Zicai Zhu and Jihong Zhu and Weihong Zhang and Zuankai Wang and Jian Lu}, doi = {10.1002/advs.202507757}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07757}, shortjournal = {Adv. Sci.}, title = {Vinyl acetate-enhanced polyvinyl chloride gel with high electroadhesion and self-heating-tunability for soft robots in freezing environments}, volume = {12}, year = {2025}, }
• (2025). A refined adaptive laboratory evolution strategy with biosensor-assisted selection resolves the Tolerance–Efficiency trade-off in toxic chemical biosynthesis. ADVS, 12(41), e07740. (www)

  @article{ , abstract = {Enhancing microbial tolerance to target chemicals through conventional adaptive laboratory evolution (ALE) is time-consuming, labor-intensive, and further constrained by the challenge of balancing improved tolerance with maintaining optimal biosynthetic efficiency. Here, this work proposes a refined ALE strategy that combines initial mutagenesis with an automated microdroplet cultivation (MMC) system, thereby expediting the acquisition of tolerance phenotypes. Integrating a biosensor-assisted high-throughput screening platform enables identification of strains exhibiting advantageous “win-win” phenotypes, characterized by simultaneous improvements in both tolerance and biosynthetic capacity. Using E. coli for the biosynthesis of 3-hydroxypropionic acid (3-HP) as a model system, this work rapidly evolves strains capable of tolerating 720 mM 3-HP within 12 days. Leveraging a newly developed and validated 3-HP-responsive biosensor, this work efficiently screens and isolates superior strains. The top-performing strain produced 86.3 g L −1 3-HP with a yield of 0.82 mol mol −1 glycerol. Transcriptomic analysis provide insights into mechanisms underlying this “win-win” phenotype. Collectively, this study establishes an effective ALE framework for accelerating the development of microbial chassis tailored for high-efficiency biochemical production.}, archive = {J_ADVS}, author = {Yufei Zhang and Junhua Yun and Guoyan Zhang and Hossain M. Zabed and Yuehui Tian and Xinrui Tang and Jia Li and Xianghui Qi}, doi = {10.1002/advs.202507740}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07740}, shortjournal = {Adv. Sci.}, title = {A refined adaptive laboratory evolution strategy with biosensor-assisted selection resolves the Tolerance–Efficiency trade-off in toxic chemical biosynthesis}, volume = {12}, year = {2025}, }
• (2025). The potential of cognitive-inspired neural network modeling framework for computer vision. ADVS, 12(41), e07730. (www)

  @article{ , abstract = {Vision deep neural networks (VDNNs) only simulate the attention-based significance selection function in human visual perception, rather than the full spectrum of visual cognition, reflecting the divide between cognitive science (CS) and artificial intelligence (AI). To address this problem, this work proposes a cognitive modeling framework (CMF) comprising three stages: functional abstraction, operator structuring, and program agent. Then, this work defines the prior information of basic image features as the long-term memory content in VDNNs. Meanwhile, this work introduces a memory modeling method for VDNNs based on the fast Fourier transform (FFT) and statistical methods—the unbiased mapping algorithm (UMA). Finally, this work develops visual cognitive neural units (VCNUs) and a baseline model (VCogM) based on CMF and UMA, and conduct performance testing experiments on different datasets such as natural scene recognition and agricultural image classification. The results show that VCogM and VCNU achieved state-of-the-art (SOTA) performance across various recognition tasks. The model's learning process is independent of data distribution and scale, fully demonstrating the rationality of cognitive-inspired modeling principles. The research findings provide new insights into the deep integration of CS and AI.}, archive = {J_ADVS}, author = {Guorun Li and Lei Liu and Xiaoyu Li and Yuefeng Du and Zhenghe Song and Xiuheng Wu}, doi = {10.1002/advs.202507730}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07730}, shortjournal = {Adv. Sci.}, title = {The potential of cognitive-inspired neural network modeling framework for computer vision}, volume = {12}, year = {2025}, }
• (2025). Hierarchically engineered flame-retardant triboelectric yarn exhibiting robust mechanical performance and humidity-boosted electrical output for firefighting applications. ADVS, 12(41), e07673. (www)

  @article{ , abstract = {As urbanization progresses and building complexity grows, fire safety gains prominence, driving up demand for intelligent, high-performance fire-fighting gear. This study develops a super-intelligent fireproof yarn (SIFY) with a coaxial structure via hierarchical textile assembly. The middle waterproof and flame-retardant layer and the outer high-strength flame-retardant poly(p-phenylene benzobisoxazole) fibers endow SIFY with top-notch flame-retardant performance (limiting oxygen index of 50.2%), high tensile strength (550.72 MPa), and remarkable wear resistance (over 12 000 rubbing cycles). These properties are currently the best among reported triboelectric yarns. Notably, the innovative design of SIFY ingeniously overcomes the limitations of triboelectric nanogenerators in humid environments. It achieves a remarkable breakthrough where the triboelectric performance increases rather than decreases with rising relative humidity. The unique properties endow SIFY with the capabilities to function as both a power source and a self-powered sensor in intelligent firefighting supplies. It can be utilized in gesture-recognition systems and intelligent firefighting ropes, thereby ensuring safer and more efficient fire-fighting operations for firefighters.}, archive = {J_ADVS}, author = {Ying Sun and Yong Zhang and Haoyu Shi and Shujuan Wang and Jinlin Liu and Yu Luo and Cheng Zhang and Kun Zhang and Shi-xiong Li and Wei Fan}, doi = {10.1002/advs.202507673}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07673}, shortjournal = {Adv. Sci.}, title = {Hierarchically engineered flame-retardant triboelectric yarn exhibiting robust mechanical performance and humidity-boosted electrical output for firefighting applications}, volume = {12}, year = {2025}, }
• (2025). Hepatic CBP/p300 orchestrate amino acid-driven gluconeogenesis through histone crotonylation. ADVS, 12(41), e07635. (www)

  @article{ , abstract = {The role of amino acid metabolism dysregulation in the development of type 2 diabetes remains elusive. Here, significant associations of human CREBBP/EP300 gene polymorphisms with circulating amino acid and glucose levels are reported. Through integrated transcriptomic, metabolomic, and CUT&Tag analyses, the molecular mechanisms underlying these correlations are investigated. Liver-specific Crebbp / Ep300 double knockout mice display elevated plasma amino acid levels and impaired hepatic glucose production caused by the downregulation of amino acid metabolism genes, which is closely linked to altered histone crotonylation and acetylation patterns at their promoters. However, key gluconeogenic genes Pck1 and G6pc are not downregulated in knockout mice. Interestingly, the level of 2-aminoadipic acid (2-AAA), a biomarker of diabetes, is significantly increased due to decreased glutaryl-CoA dehydrogenase (GCDH) expression in CBP/p300-deficient livers. Treatment with 2-AAA or overexpression of GCDH enhances amino acid-driven gluconeogenesis through histone crotonylation-mediated transcriptional activation of amino acid metabolism genes in primary mouse hepatocytes, whereas GCDH knockdown exhibits an opposite result. Furthermore, targeted hepatic knockdown of CBP/p300 markedly attenuates hepatic glucose production from amino acids in diabetic mice. In sum, these findings underscore the pivotal role of CBP/p300 in linking amino acid catabolism to gluconeogenesis through histone crotonylation in a cell-autonomous manner.}, archive = {J_ADVS}, author = {Chunxiang Sheng and Tianjiao Li and Hong Lin and Xiaoqin Ma and Feiye Zhou and Mingzhu Li and Yiru Wang and Shushu Wang and Jialin Tan and Junmin Chen and Yulin Yang and Jianmin Liu and Yufang Bi and Jieli Lu and Xiao Wang and Libin Zhou}, doi = {10.1002/advs.202507635}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07635}, shortjournal = {Adv. Sci.}, title = {Hepatic CBP/p300 orchestrate amino acid-driven gluconeogenesis through histone crotonylation}, volume = {12}, year = {2025}, }
• (2025). Revealing a pathway for low-temperature recrystallization in germanium. ADVS, 12(41), e07630. (www)

  @article{ , abstract = {Thermally activated annealing in semiconductors faces inherent limitations, such as dopant diffusion. Here, a nonthermal pathway is demonstrated for a complete structural restoration in predamaged germanium via ionization-induced recovery. By combining experiments and modeling, this study reveals that the energy transfer of only 2.4 keV nm −1 from incident ions to target electrons can effectively annihilate pre-existing defects and restore the original crystalline structure at room temperature. Moreover, it is revealed that the irradiation-induced crystalline-to-amorphous (c/a) transformation in Ge is reversible, a phenomenon previously considered unattainable without additional thermal energy imposed during irradiation. For partially damaged Ge, the overall damage fraction decreases exponentially with increasing fluence. Surprisingly, the recovery process in preamorphized Ge starts with defect recovery outside the amorphous layer and a shrinkage of the amorphous thickness. After this initial stage, the remaining damage decreases slowly with increasing fluence, but full restoration of the pristine state is not achieved. These differences in recovery are interpreted in the framework of structural differences in the initial defective layers that affect recovery kinetics. This study provides new insights on reversing the c/a transformation in Ge using highly-ionizing irradiation and has broad implications across materials science, radiation damage mitigation, and fabrication of Ge-based devices.}, archive = {J_ADVS}, author = {Gihan Velişa and Eva Zarkadoula and Decebal Iancu and Maria D. Mihai and Alexandre Boulle and Yang Tong and Da Chen and Yanwen Zhang and William J. Weber}, doi = {10.1002/advs.202507630}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07630}, shortjournal = {Adv. Sci.}, title = {Revealing a pathway for low-temperature recrystallization in germanium}, volume = {12}, year = {2025}, }
• (2025). Integration of genetic and imaging data for alzheimer's disease diagnosis and interpretation. ADVS, 12(41), e07629. (www)

  @article{ , abstract = {Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by complex interactions between genetic risk factors and structural brain changes. Traditional diagnostic approaches that rely on single-modality data, such as imaging or genomics alone, often fall short in both predictive accuracy and biological interpretability. To address these limitations, AlzCLIP, a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI-derived imaging features into a unified embedding space is introduced. This joint representation captures disease-relevant interactions between genetic variation and brain structure, enabling both accurate diagnosis and mechanistic insight into AD. AlzCLIP is trained and evaluated on two large-scale cohorts, the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the UK Biobank (UKB), and demonstrated robust diagnostic performance, outperforming state-of-the-art baselines by up to 19%. More importantly, the model yields interpretable outputs through feature importance and interaction analyses, identifying key contributors to AD risk, including rs1135173, rs7575209, and rs66763080, as well as structural markers such as hippocampal volume and precuneus surface area. Notably, AlzCLIP uncovered genotype-specific effects on imaging phenotypes. Specifically, rs11077054 is associated with increased white matter hyperintensity burden and amygdala atrophy, suggesting a potential link between this variant and AD-related structural brain changes. Together, the results highlight AlzCLIP's potential to enhance AD risk prediction and provide biologically grounded insights by integrating multi-modal genomic and imaging data.}, archive = {J_ADVS}, author = {Yanfei Wang and Qing Wang and Minghao Zhou and Jialu Liang and Lei You and Breton Asken and Xiaobo Zhou and Qianqian Song}, doi = {10.1002/advs.202507629}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07629}, shortjournal = {Adv. Sci.}, title = {Integration of genetic and imaging data for alzheimer's disease diagnosis and interpretation}, volume = {12}, year = {2025}, }
• (2025). Big data and AI-powered modeling: A pathway to sustainable precision animal nutrition. ADVS, 12(41), e07564. (www)

  @article{ , abstract = {The global livestock production system faces significant challenges for sustainable development, including feed resource shortage and environmental pressures. Precision animal nutrition is crucial in addressing these challenges, in which the mathematical model is an indispensable tool. The traditional mathematical models exhibit certain limitations, particularly in accommodating the emerging demands of precision nutrition and feeding for individuals. New technologies, especially big data and artificial intelligence (AI), have shown great potential to mitigate the above shortcomings. This review has summarized the current landscape and applications of big data and AI-powered modeling in animal nutrition and feeding, covering techniques including intelligent data acquisition, in vitro kinetics and multi-omics data mining, data augmentation, advanced and explainable machine learning algorithms, multi-objective and heuristic algorithms, and life cycle assessment-based sustainability evaluation with case studies in pigs and alternative feed ingredients. Furthermore, this review has introduced the next-generation model techniques, including those based on large language models, multi-agents, and embodied AI robots, depicted the potential translation of the advancements from animal nutrition to human health, and discussed the limitations of AI-powered modeling techniques. These pioneering techniques will provide new tools and paradigms for research and practices in animal nutrition and further promote animal husbandry's sustainable development.}, archive = {J_ADVS}, author = {Shuai Zhang and Changhua Lai and Jinbiao Zhao and Junjun Wang}, doi = {10.1002/advs.202507564}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07564}, shortjournal = {Adv. Sci.}, title = {Big data and AI-powered modeling: A pathway to sustainable precision animal nutrition}, volume = {12}, year = {2025}, }
• (2025). Nanoshield-assisted viral gene therapy with induction of non-apoptotic cell death and durable antitumor immunity. ADVS, 12(41), e07550. (www)

  @article{ , abstract = {Non-apoptotic cell death have emerged as promising strategies to overcome apoptotic resistance in cancer therapy. We suggest a hybrid gene delivery platform integrating adeno-associated virus (AAV)-mediated expression of receptor-interacting kinase 3(RIPK3) with manganese dioxide-polyethyleneimine (MnO 2 -PEI) to induce necroptosis and immunogenic cell death (ICD), thereby remodeling the tumor microenvironment and enhancing antitumor immunity. This platform combines high transduction efficiency with the tumor-accumulation ability and immunostimulatory potential of non-viral carriers. The MnO 2 –PEI nanosheets shields AAV from immune and hepatic clearance, thus enhancing tumor accumulation. This addresses a key limitation of naked AAV delivery. Simultaneously, the AAV payload offsets non-viral systems’ low gene delivery efficiency. The platform induces robust damage-associated molecular patterns (DAMP) and tumor antigen release, thereby promoting dendritic cell maturation and cytotoxic T cell infiltration. Furthermore, Mn²⁺-induced reactive oxygen species (ROS) amplify ferroptosis and, in conjunction with RIPK3-mediated necroptosis, remodel the immunosuppressive tumor microenvironment by promoting M1 macrophage polarization and a Th1-type immune response. In tumor re-challenge models, AAV/MnO 2 –PEI-treated mice exhibited durable antitumor immunity, thereby highlighting the potential of platform to establish long-term immune memory. This hybrid delivery system provides a potent strategy for synergistic cancer immunotherapy, effectively overcoming the limitations of both viral and non-viral vectors.}, archive = {J_ADVS}, author = {Soo-Hwan Lee and Yunkyeong Cho and Seunghwan Bang and Daeun Sung and Jahyun Koo and Seoyoung Kim and Youngil Koh and Hojun Kim and Hyojin Lee}, doi = {10.1002/advs.202507550}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07550}, shortjournal = {Adv. Sci.}, title = {Nanoshield-assisted viral gene therapy with induction of non-apoptotic cell death and durable antitumor immunity}, volume = {12}, year = {2025}, }
• (2025). H3K27ac is essential for human naive pluripotency modulated by m6A-driven EP300 expression. ADVS, 12(41), e07549. (www)

  @article{ , abstract = {Human pluripotent stem cells (hPSCs) can transition between primed and naive states, each defined by unique epigenetic features crucial for early human development. However, the precise regulatory mechanisms of these transitions, particularly involving the roles of H3K27ac and m6A modifications, remain unclear. Here, it is revealed that H3K27ac is essential for establishment of human naive pluripotency. This elevation is critical for maintaining the naive state, as inhibiting H3K27ac disrupts naive pluripotency, while enhancing it promotes the naive state. Furthermore, it is discovered that m6A, via the enzyme METTL3, indirectly controls H3K27ac by regulating EP300 expression, an enzyme involved in H3K27ac deposition. METTL3 overexpression suppresses EP300 protein, thereby reducing H3K27ac modification and impeding naive pluripotency. These findings uncover a novel interplay between H3K27ac and m6A, advancing the understanding of stem cell regulation. This work provides new insights into the epigenetic control of hPSCs, with potential implications for developmental biology and regenerative medicine.}, archive = {J_ADVS}, author = {Chenrui An and Ke Zhong and Xiangjin Kang and Yingying Zhang and Yudan Shang and Hao Liu and Yushan Ji and Jinbei Zeng and Jiajin Lin and Long Jin and Zelong Lin and Yang Yu and Xuetao Shi and Yong Fan}, doi = {10.1002/advs.202507549}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07549}, shortjournal = {Adv. Sci.}, title = {H3K27ac is essential for human naive pluripotency modulated by m6A-driven EP300 expression}, volume = {12}, year = {2025}, }
• (2025). Controllable generation of pathogen-specific antimicrobial peptides through knowledge-aware prompt diffusion model. ADVS, 12(41), e07457. (www)

  @article{ , abstract = {Generative models have shown considerable promise in antimicrobial peptide design; however, their ability to generate pathogen-specific peptides remains limited due to data scarcity. In this study, KPPepGen, a controllable generative framework that leverages knowledge-aware pathogen prompts derived from pre-training on Gene Ontology and pathogen knowledge graphs, which act as knowledge injections to guide a diffusion model in generating biologically plausible peptides tailored to specific pathogens, is introduced. Then, KPPepGen is extended for peptide optimization by integrating prompt-guided partial diffusion with multi-site combinatorial mutations. Experimental results show that KPPepGen can simultaneously generate valid peptides for 56 distinct pathogens, achieving high novelty, favorable physicochemical properties, and delivering over a 10% performance improvement for pathogens with limited training data. Further analysis demonstrates that KPPepGen effectively captures essential sequence and structure patterns characteristic of individual pathogens. The optimization results reveal a high success rate of 44.3% for Magainin 2, along with an average improvement of 7.6% compared to the ESM-based method, underscoring the effectiveness of KPPepGen in enhancing the overall performance of peptides. Finally, for clinically relevant pathogens such as E. coli and S. aureus , KPPepGen successfully generated nine novel peptides that exhibit strong antimicrobial activity and low cytotoxicity in the wet-lab evaluation.}, archive = {J_ADVS}, author = {Yongkang Wang and Menglu Li and Feng Huang and Minyao Qiu and Wen Zhang}, doi = {10.1002/advs.202507457}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07457}, shortjournal = {Adv. Sci.}, title = {Controllable generation of pathogen-specific antimicrobial peptides through knowledge-aware prompt diffusion model}, volume = {12}, year = {2025}, }
• (2025). CRCFound: A colorectal cancer CT image foundation model based on self-supervised learning. ADVS, 12(41), e07339. (www)

  @article{ , abstract = {Accurate risk stratification is crucial for determining the optimal treatment plan for patients with colorectal cancer (CRC). However, existing deep learning models perform poorly in the preoperative diagnosis of CRC and exhibit limited generalizability, primarily due to insufficient annotated data. To address these issues, CRCFound, a self-supervised learning-based CT image foundation model for CRC is proposed. After pretraining on 5137 unlabeled CRC CT images, CRCFound can learn universal feature representations and provide efficient and reliable adaptability for various clinical applications. Comprehensive benchmark tests are conducted on six different diagnostic tasks and two prognosis tasks to validate the performance of the pretrained model. Experimental results demonstrate that CRCFound can easily transfer to most CRC tasks and exhibit outstanding performance and generalization ability. Overall, CRCFound can solve the problem of insufficient annotated data and perform well in a wide range of downstream tasks of CRC, making it a promising solution for accurate diagnosis and personalized treatment of CRC patients.}, archive = {J_ADVS}, author = {Jing Yang and Du Cai and Junwei Liu and Zhenfeng Zhuang and Yibin Zhao and Feng-ao Wang and Chenghang Li and Chuling Hu and Baowen Gai and Yiping Chen and Yixue Li and Liansheng Wang and Feng Gao and Xiaojian Wu}, doi = {10.1002/advs.202407339}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07339}, shortjournal = {Adv. Sci.}, title = {CRCFound: A colorectal cancer CT image foundation model based on self-supervised learning}, volume = {12}, year = {2025}, }
• (2025). Ultrahigh-temperature-tolerance lithium metal batteries enabled by molecular-level polymer configuration design with low-entropy-penalty effect. ADVS, 12(41), e07191. (www)

  @article{ , abstract = {Despite their immense potential for next-generation energy storage, the practical implementation of temperature-tolerant lithium metal batteries (LMBs) under extreme thermal conditions continues to face formidable challenges. In this study, an ultrahigh-temperature-tolerance polymer-based electrolyte (UPE) prototype with a low-entropy-penalty effect is proposed. This electrolyte features a carefully engineered molecular configuration that enables stable operation of polymer-based LMBs across a broad temperature range (25–150 °C). Comprehensive experimental and theoretical analyses confirm that the unique “ester-ether-fluorinated segment” architecture enables the formation of a robust coordination framework through Li⁺-multivalent ether/ester interactions and effective Li + -ether strong-solvent-cage decoupling. The resulting polymer electrolyte integrates reactive carboxyl groups, alkali-metal-soluble ether moieties, and fluorinated segments that provide inert yet efficient ion conduction pathways. This synergistic configuration achieves high ionic conductivity, significantly improved lithium-ion transference numbers, and excellent interfacial compatibility with lithium metal. This work presents a molecular-level polymer design framework, providing a compelling direction for the development of high-performance, thermally stable lithium-metal batteries.}, archive = {J_ADVS}, author = {Weiting Ma and Shunshun Zhao and Shuang Wan and Jiajun Gong and Sinian Yang and Yong Chen and Shimou Chen and Guoxiu Wang}, doi = {10.1002/advs.202507191}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07191}, shortjournal = {Adv. Sci.}, title = {Ultrahigh-temperature-tolerance lithium metal batteries enabled by molecular-level polymer configuration design with low-entropy-penalty effect}, volume = {12}, year = {2025}, }
• (2025). Cell fate determination and lineage tracing: Technological evolution and multidimensional applications. ADVS, 12(41), e07183. (www)

  @article{ , abstract = {Cell fate determination is a fundamental process in multicellular development. In multicellular organisms, cells display plasticity in their fate, allowing them to revert to prior states or adopt alternative differentiation pathways, thereby altering their identity and functional specialization in response to specific stimuli. Investigating cell fate determination and its plasticity enhances our understanding of organ development, tissue homeostasis, and disease pathogenesis and progression, providing novel insights into regenerative medicine strategies. Lineage tracing technologies have fundamentally revolutionized this understanding of cell fate dynamics by enabling the identification and tracking of cells and their progeny in vivo. These technologies have progressed significantly, from the direct observation and manual annotation of cell lineage trees to complex recombinase-mediated genetic labeling techniques. With the advent of sequencing technologies, the resolution and scale of lineage tracing have also developed toward the single-cell level in individual organisms. Furthermore, lineage tracing is increasingly expanding to investigate how the tissue microenvironment influences cell fate decisions. Here, the evolution of lineage tracing technologies is introduced and their applications in cell fate determinations across development, regeneration, and diseases contexts.}, archive = {J_ADVS}, author = {Hui Chen and Zhicong Liu and Qiang Shu and Bin Zhou}, doi = {10.1002/advs.202507183}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e07183}, shortjournal = {Adv. Sci.}, title = {Cell fate determination and lineage tracing: Technological evolution and multidimensional applications}, volume = {12}, year = {2025}, }
• (2025). PD-l1-targeting biomimetic photoresponsive thermosensitive liposomes for triple-negative breast cancer. ADVS, 12(41), e06841. (www)

  @article{ , abstract = {Peptide-based therapeutic strategies offer considerable potential for tumor immunotherapy but suffer from poor systemic bioavailability, rapid plasma clearance, and limited tumor-targeting efficiency. To address these challenges, a biomimetic, photothermal-responsive liposomal delivery system was developed that enables precise delivery of immunotherapeutic peptides while enhancing the synergistic effects of photothermal therapy. This system enhances peptide stability through fluorination, disrupts post-translational modifications of PD-L1, and promotes its degradation, thereby amplifying the anti-tumor immune response. The carrier core consisted of thermosensitive 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes loaded with the low-toxicity photosensitizer indocyanine green (ICG), which facilitated controlled peptide release via the photothermal effect. Simultaneously, mild photothermal stimulation induced immunogenic cell death (ICD), further strengthening anti-tumor immunity. To enhance tumor targeting, extend systemic circulation time, and improve drug accumulation at tumor sites, the carrier surface was coated with a platelet membrane, which increased biocompatibility and promoted immune evasion. Notably, in vivo studies demonstrated that the developed bioengineering platform significantly suppressed tumor growth in both solid and diffuse malignant tumors while inducing persistent immune memory, thereby facilitating long-term anti-tumor immune responses. Collectively, this approach establishes a novel framework for integrating peptide drug delivery with photothermal therapy, offering a promising strategy for advancing tumor immunotherapy.}, archive = {J_ADVS}, author = {Manman Tan and Chengyu Shi and Guangyi Chi and Xinwan Su and Fangzhou Liu and Linyu Zhu and Guangqian Cheng and Xiangyi Chen and Meng Yu and Yijian Chen and Ying Wang and Yu Chen and ShuLing Yan and Wenfei Wu and Qingfeng Yan and Jianzhong Shao and Kai Wang and Xiangrui Liu and Min Zhou and Aifu Lin}, doi = {10.1002/advs.202506841}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06841}, shortjournal = {Adv. Sci.}, title = {PD-l1-targeting biomimetic photoresponsive thermosensitive liposomes for triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). A “Mesoporous oxygen chamber” scaffold with antibacterial and early immunomodulatory effect for promoting bone regeneration. ADVS, 12(41), e06737. (www)

  @article{ , abstract = {Regeneration of bone defects are frequently hindered by severe inflammation, immunogenicity after bone repairing material implantation, and microbial infections. Oxygen therapy is reported to downregulate the levels of pro-inflammatory cytokines and proteases, alleviating inflammation and promoting regeneration. Mesoporous bioactive glass (MBG) is marked by its osteoinductivity and mesoporous structure for drug delivery. In this study, an oxygen-loaded and antimicrobial peptide (AP)-functionalized scaffold (MBGAPO) is synthesized and proven with sufficient oxygen-delivery capacity of mesopores, promising antibacterial ability against E.coli and MRSA , multiplex-immunomodulatory effects, and potent osteoinductivity both in vitro and in vivo. In cranial defect models of mouse and rat, MBGAPO created a mild immune microenvironment that accelerated inflammation alleviation and facilitated immune cells transformation toward anti-inflammatory phenotypes in the initial stage of bone regeneration, and exhibited a superior immune modulatory effect than Bio-oss (an FDA-approved bone substitute). In vivo results indicated that oxygen delivery promoted bone regeneration within the scaffold, and AP functionalization facilitated the bridging of surrounding tissue in the defect area. In summary, mesoporosity-based oxygen delivery is first proven as a promising osteoimmunology therapeutic strategy, and its combination with antimicrobial peptides can be extended to more regenerative and disease treatment applications that may arouse broader interests of researchers.}, archive = {J_ADVS}, author = {You Fu and Dan Lin and Zhicen Lu and Jian Wang and Jing Zhao and Zhiyuan Zhang and Bing Fang and Xiao Yang}, doi = {10.1002/advs.202506737}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06737}, shortjournal = {Adv. Sci.}, title = {A “Mesoporous oxygen chamber” scaffold with antibacterial and early immunomodulatory effect for promoting bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Sustainable and direct upcycling of waste graphite anodes via deep eutectic solvents. ADVS, 12(41), e06637. (www)

  @article{ , abstract = {Lithium-ion batteries (LIBs) have flourished in power and energy storage, followed by the waste batteries that are pouring into the market. For waste graphite anode, how to deal with high efficiency, high economic efficiency, and low environmental pollution has become a huge challenge. In the work, a deep eutectic solvent (DES), with a low melting point, low cost, and natural environmental protection, is applied as a green reagent to realize the sustainable and direct upcycling of waste graphite. Substances in DES existing in the form of ions and charged P-containing groups are more likely to attack defect-rich graphite and realize in situ phosphorus doping, and doped phosphorus participates in the construction of Li 3 PO 4 -rich solid electrolyte interphase (SEI). Due to the reconstruction of phosphate-rich interfacial film, the capacity of regenerated graphite maintains as high as 365 mAh g −1 at 0.5C with a capacity retention rate of 95.5%, which is much higher than that of waste graphite and even commercial graphite. In addition, the low melting point of DES makes the regeneration temperature significantly lower, so that the strategy reduces the CO 2 emissions of energy consumption. More importantly, the environment and economy have been optimized, which is conducive to its large-scale promotion in industry.}, archive = {J_ADVS}, author = {Xue Liu and Shaoqing Liu and Junhan Pu and Rong Zeng and Tao Wang and Jiashen Meng and Jean-Jacques Gaumet and Wen Luo and Jianwen Liu}, doi = {10.1002/advs.202506637}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06637}, shortjournal = {Adv. Sci.}, title = {Sustainable and direct upcycling of waste graphite anodes via deep eutectic solvents}, volume = {12}, year = {2025}, }
• (2025). Geometrically confined strain engineering of MoS2 via quasi-van der waals recrystallization of gold nanopillars. ADVS, 12(41), e06488. (www)

  @article{ , abstract = {Transition metal dichalcogenides (TMDs) are promising materials for next-generation electronics due to their atomically thin body and exceptional optoelectronic properties. Their ultrathin and stiff nature make them highly sensitive to strain, enabling modulation of lattice and band structures and enhancing carrier mobility via tensile strain. While uniform strain degrades optical properties of MoS 2 due to the indirect bandgap, localized strain enhances them through the funnel effect, highlighting the importance of localized strain engineering. In this study, localized strain is achieved in monolayer MoS 2 using geometrically confined quasi-van der Waals (qvdW) recrystallization of patterned gold nanopillars. After transferring hBN-encapsulated MoS 2 onto the pillars and annealing, the gold recrystallizes into thicker, more crystalline structures, inducing ≈0.15% local tensile strain. This results in a 65-fold increase in photoluminescence (PL) intensity due to the funnel effect, Fabry-Pérot interference, and Purcell effect. Additionally, field-effect mobility is significantly enhanced to 100 cm 2 V −1 s −1 , a two-order of magnitude improvement. The work shows a way to apply local strain in MoS 2 using geometrically confined gold pillars via qvdW recrystallization, offering a possibility for advanced optoelectronic devices.}, archive = {J_ADVS}, author = {Kyungmin Yang and Yuna Lee and Dongjoon Rhee and Bongjun Choi and Adam Alfieri and Marija Drndić and Deep Jariwala and Gwan-Hyoung Lee}, doi = {10.1002/advs.202506488}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06488}, shortjournal = {Adv. Sci.}, title = {Geometrically confined strain engineering of MoS2 via quasi-van der waals recrystallization of gold nanopillars}, volume = {12}, year = {2025}, }
• (2025). One-step tunable MoS2 with enhanced zn2+ diffusion for high-energy zinc-ion hybrid capacitors. ADVS, 12(41), e06467. (www)

  @article{ , abstract = {Zinc-ion hybrid capacitors (ZIHCs) offer a promising solution for large-scale energy storage, combining battery-like energy density with superior power performance. However, their development is challenged by the scarcity of suitable cathode materials, as well as poor reversibility and sluggish Zn 2+ diffusion due to its large hydrated ion size and limited efficiency. To address this, a one-step, tunable synthesis approach is developed for growing MoS 2 on carbon cloth via an ethylene glycol (EG) intercalation strategy, effectively transforming inactive interlayer cavities into highly active sites. Density functional theory calculations reveal that EG intercalation substantially lowers the energy barrier for hydrated Zn 2+ intercalation, significantly improving Zn 2+ storage capability. Experimentally, EG molecules expand the MoS 2 interlayer spacing from 0.617 to 0.948 nm, creating wider diffusion channels for Zn 2+ transport. The optimized EG-MoS 2 exhibits a high specific capacitance of 240.5 F/g at 0.7 A/g, which is three orders of magnitude higher than that of pristine MoS 2 , along with exceptional rate capability. Notably, the assembled ZIHC exhibited a high energy density of 40.42 Wh kg −1 at a power density of 385 W kg −1 while demonstrating outstanding cycling stability over 5000 cycles. This work unveils a powerful strategy for engineering high-performance MoS 2 -based cathodes, advancing next-generation ZIHCs development.}, archive = {J_ADVS}, author = {Harshitha B. Tyagaraj and Vikram Mahamiya and Supriya J. Marje and Gagankumar Sakleshpur Kumar and Shalmali R. Burse and Swapnil R Patil and Ebrahim Al Hajri and Nilesh R. Chodankar and Yun Suk Huh and Young Kyu Han}, doi = {10.1002/advs.202506467}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06467}, shortjournal = {Adv. Sci.}, title = {One-step tunable MoS2 with enhanced zn2+ diffusion for high-energy zinc-ion hybrid capacitors}, volume = {12}, year = {2025}, }
• (2025). PPP1R3B suppresses atherosclerosis by promoting the m2 polarization of macrophages through glycogen metabolic reprogramming. ADVS, 12(41), e06345. (www)

  @article{ , abstract = {Identifying targets that promote M2 macrophage polarization in the hypoxic plaque microenvironment is crucial for modulating immune metabolism and optimizing energy dynamics in atherosclerotic cardiovascular disease (ASCVD) treatment. The high phagocytic activity of M2 macrophages reduces foam cell formation. Their secretion of anti-inflammatory cytokines enhances plaque stability, mitigating atherosclerosis progression. Through high-throughput sequencing and multi-omics bioinformatics analysis, protein phosphatase 1 regulatory subunit 3B ( PPP1R3B ) is identified as a key regulator linking glycogen metabolism to macrophage polarization. The integrated approach combined transcriptomic analysis of human atherosclerotic plaques (GSE57614) with RNA-seq of PPP1R3B -modulated macrophages, revealing its dual role. PPP1R3B induces anti-inflammatory M2 macrophage polarization and maintains energy supply in plaques. Its absence accelerates plaque progression. PPP1R3B regulates M2 macrophage polarization and energy metabolism via phosphorylated STAT3 (p-STAT3), which plays a dual role by activating anti-inflammatory transcriptional programs through the PPAR-γ/PGC-1α/CD206 axis in the nucleus and enhancing glycogenolysis-mediated metabolic activity via the p-GSK-3β/p-PYGL/p-GYS2 axis in mitochondria. STAT3 plays a dual role in metabolic regulation and macrophage phenotype modulation. By orchestrating glycogen metabolic reprogramming, PPP1R3B -induced M2 polarization presents a novel strategy for anti-ASCVD drug development, with significant potential for clinical translation.}, archive = {J_ADVS}, author = {Lin Shen and Junchao Yu and Weiqian Chen and Yanran Bi and Zhangyu Yang and Chenying Lu and Chengli Jiang and Yang Yang and Minjiang Chen and Jianhua Zou and Lingchun Lv and Xiaoyuan Chen and Jiansong Ji}, doi = {10.1002/advs.202506345}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06345}, shortjournal = {Adv. Sci.}, title = {PPP1R3B suppresses atherosclerosis by promoting the m2 polarization of macrophages through glycogen metabolic reprogramming}, volume = {12}, year = {2025}, }
• (2025). CXCR1 depletion in Ly6C+ cDC2 alleviates acute lung injury via modulation of Th17/Treg balance. ADVS, 12(41), e06287. (www)

  @article{ , abstract = {Dendritic cells (DCs) play a critical role in the development of acute lung injury (ALI) / acute respiratory distress syndrome (ARDS), but the underlying mechanisms remain poorly understood, due to their heterogeneous phenotype and function. In this study, a novel DC subset is defined in mice, Ly6C⁺ cDC2, which corresponds to CD14⁺ cDC2 in humans. These subsets highly express C-X-C motif chemokine receptor 1 (Cxcr1) and exhibit pro-inflammatory effects during ALI. Ex vivo, Ly6C⁺ cDC2s release higher levels of Il-6 and Il-1β, thereby promoting naïve T cells to differentiate into Th17 cells. Notably, Cxcr1 deficiency reduced the release of Il-6 and Il-1β from Ly6C⁺ cDC2s and shifted naïve T cells toward Treg differentiation, resulting in a decreased Th17/Treg ratio. In vivo, adoptive transfer of Ly6C⁺ cDC2s increased the Th17/Treg ratio in the lungs and spleens of LPS-treated mice, exacerbating lung injury. Specific depletion of Cxcr1 in DCs significantly reduced the severity of ALI and mortality. Mechanistically, it is found that Cxcr1 regulates the expression of Il-6 and Il-1β in Ly6C⁺ cDC2s through the MEK1/ERK/NF-κB pathway. Collectively, pro-inflammatory Ly6C⁺ cDC2s are identified as key effector cells mediating the role of Cxcr1 signaling in modulating T cell differentiation, driving the progression of ALI.}, archive = {J_ADVS}, author = {Shenghui Li and Wei Zhuang and Yang Wang and Hao Qin and Xichun Qin and Xianliang Yan and Xuefei Hu and Xiucheng Liu and Chang Chen}, doi = {10.1002/advs.202506287}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06287}, shortjournal = {Adv. Sci.}, title = {CXCR1 depletion in Ly6C+ cDC2 alleviates acute lung injury via modulation of Th17/Treg balance}, volume = {12}, year = {2025}, }
• (2025). Internal phase separation in synthetic DNA condensates. ADVS, 12(41), e06275. (www)

  @article{ , abstract = {Biomolecular condensates regulate cellular biochemistry by organizing enzymes, substrates and metabolites, and often acquire partially de-mixed states whereby distinct internal domains play functional roles. Despite their physiological relevance, questions remain about the principles underpinning the emergence of multi-phase condensates. Here, a model system of synthetic DNA nanostructures able to form monophasic or biphasic condensates is presented. Key condensate features, including the degree of interphase mixing and the relative size and spatial arrangement of domains, can be controlled by altering nanostructure stoichiometries. The modular nature of the system facilitates an intuitive understanding of phase behavior, and enables mapping of the experimental phenomenology onto a predictive Flory-Huggins model. The experimental and theoretical framework introduced is expected to help address open questions on multiphase condensation in biology and aid the design of functional biomolecular condensates in vitro, in synthetic cells, and in living cells.}, archive = {J_ADVS}, author = {Diana A. Tanase and Dino Osmanović and Roger Rubio-Sánchez and Layla Malouf and Elisa Franco and Lorenzo Di Michele}, doi = {10.1002/advs.202506275}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06275}, shortjournal = {Adv. Sci.}, title = {Internal phase separation in synthetic DNA condensates}, volume = {12}, year = {2025}, }
• (2025). Serine/Threonine kinase 33 as a novel target of bufalin in treatment of triple-negative breast cancer. ADVS, 12(41), e06253. (www)

  @article{ , abstract = {Identifying novel therapeutic targets and drugs is crucial for treating triple-negative breast cancer (TNBC). Bufalin, a key active ingredient of the traditional Chinese medicine HuaChansu , has been employed in tumor therapy. Here, SPR-LC-MS/MS is employed to characterize the targets of Bufalin and found that serine/threonine kinase 33 (STK33) possesses a strong binding affinity to Bufalin. Combining molecular docking, SPR analysis, and Biotin-pulldown analysis, it is demonstrated that STK33 can bind Bufalin. Notably, STK33 is highly expressed in TNBC and is associated with poor prognosis in TNBC patients. STK33 knockdown inhibits TNBC cell growth both in vitro and in vivo. Mechanistically, STK33 phosphorylates and stabilizes CCAR1, which promotes tumor growth and metastasis, thereby driving tumor progression. Further analyses confirmed that Methionine 245 of STK33 is required for STK33-Bufalin interaction, and Bufalin treatment promotes the degradation of STK33 protein by destroying the STK33-HSP90 complex. Through in vitro, in vivo, and in patient-derived TNBC organoids, it is observed that Bufalin inhibited the TNBC cell proliferation by targeting STK33. This study not only establishes Bufalin as a putative STK33 degrader to suppress TNBC but also identifies STK33 as a pro-cancer factor in TNBC, presenting a potential therapeutic target for TNBC.}, archive = {J_ADVS}, author = {Shilong Jiang and Junyan Liu and Hui Li and Chan Zou and Xiaoya Wan and Rong Gong and Ting Jiang and Changxin Zhong and Zonglin Chen and Zewu Zhu and Dongsheng Cao and Yan Cheng}, doi = {10.1002/advs.202506253}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06253}, shortjournal = {Adv. Sci.}, title = {Serine/Threonine kinase 33 as a novel target of bufalin in treatment of triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). The composite antiadhesion barrier facilitated fibroblast autophagy activation for tendon repair. ADVS, 12(41), e06204. (www)

  @article{ , abstract = {While dysregulated autophagy is implicated in fibrotic processes in various organs, its specific role in peritendinous fibrosis and tendon adhesion formation remains to be elucidated. This study hypothesizes that autophagy exerts a protective effect, inhibiting adhesion formation following tendon injury. Furthermore, it is proposed that interleukin-37 (IL-37) can be a potential therapeutic target for preventing tendon adhesions through autophagy activation. Therefore, an innovative three-layer composite antiadhesion barrier (pDNA@E–H–E′) equipped with on-demand and unidirectional delivery strategy of bioactive plasmid DNA (pDNA) for IL-37 overexpression is designed. The novel finding of the fibroblast's autophagy activity as a protective factor in tendon adhesion highlights the encapsulation of IL-37-encoding pDNA nanocomposites in barrier for reaching supreme antiadhesion efficacy. Moreover, the reactive-oxygen-species-responsive and releasing-direction-guided pDNA@E–H–E′ membranes afford wonderful inhibition of fibroblast proliferation, fibroblast-to-myofibroblast differentiation, and collagen synthesis by enhancing autophagy. Further in a rat Achilles tendon adhesion model, pDNA@E–H–E′ membranes also significantly suppress peritendinous adhesion formation on the repaired sites and promote the scarless repair of Achilles tendon with optimum efficiency. In all, this study provides a promising approach for preventing tendon adhesion by employing a composite barrier with on-demand and unidirectional delivery strategy.}, archive = {J_ADVS}, author = {Zhenyu Sun and Jingwen Liu and Liang Chen and Zhen Wang and Fei Wang and Shen Liu}, doi = {10.1002/advs.202506204}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06204}, shortjournal = {Adv. Sci.}, title = {The composite antiadhesion barrier facilitated fibroblast autophagy activation for tendon repair}, volume = {12}, year = {2025}, }
• (2025). Bismuth silicate catalyst for efficient electrocatalytic CO2 reduction and electrolyte-free formic acid production. ADVS, 12(41), e06034. (www)

  @article{ , abstract = {The rising atmospheric CO 2 levels pose significant environmental challenges. Electrocatalytic CO 2 reduction offers a promising approach for converting CO 2 into valuable chemicals such as formate or formic acid. However, the development of efficient electrocatalysts, a deeper mechanistic understanding, and the minimization of energy consumption during product purification remain critical challenges to practical carbon utilization. Here, layered Bi 2 SiO 5 is designed as a pre-catalyst, which undergoes electrochemical reconstruction into a Bi@Bi 2 O 2 CO 3 composite. The catalyst achieves a Faradaic efficiency for formate of 95.8% at −1.06 V and maintains over 90% across a wide potential range, outperforming Bi 2 O 2 CO 3 and Bi. In situ characterizations reveal that Bi 2 SiO 5 converts to Bi 2 O 2 CO 3 through anion exchange, followed by partial reduction to form Bi@Bi 2 O 2 CO 3 . Charge redistribution at the interface facilitates the proton-coupled electron transfer of * CO 2 and desorption of * HCOOH, thereby enhancing formate production, as supported by theoretical calculations. Furthermore, integrating the catalyst into an electrolytic cell containing solid-state electrolytes enables the continuous production of electrolyte-free formic acid, simplifying product separation and purification. This work provides insights for the development of practical carbon utilization.}, archive = {J_ADVS}, author = {Ping Zhu and Xin-Hao Cai and Cheng-Cheng Huang and Ying Zhou and Na Chu and Zi-Bo Jing and Wen-Long Wang and Bilu Liu and Yong Jiang and Qian-Yuan Wu}, doi = {10.1002/advs.202506034}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06034}, shortjournal = {Adv. Sci.}, title = {Bismuth silicate catalyst for efficient electrocatalytic CO2 reduction and electrolyte-free formic acid production}, volume = {12}, year = {2025}, }
• (2025). Src reduces neutrophil extracellular traps generation and resolves acute organ damage. ADVS, 12(41), e06028. (www)

  @article{ , abstract = {Neutrophil extracellular traps (NETs) are key factors mediating acute inflammatory injury. However, the underlying mechanisms and potential therapeutic targets remain unclear. Previous results suggest Src may be involved in regulating the NETs formation. Here, Src is found activated in the NETs model in vitro, in the murine- and human-derived neutrophils (acute pancreatitis and sepsis). Moreover, p-Src expression correlates with the clinical prognosis of acute pancreatitis and sepsis patients. Meanwhile, the inhibition of Src activity (gene silencing or inhibitors) inhibits NETs formation in vitro. Mechanistically, Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF/MEK/ERK pathway by mediating PKC phosphorylation. In vivo, neutrophil Src - specific defect significantly reduces acute inflammatory response, organ damage, and the NETs formation in damaged tissue. Eventually, Src inhibitors are used and validated their pharmacological effects. These results identify Src as a key mediator in intracellular ROS production, NETs formation, and acute organ injury. Hence, Src inhibition may represent a promising therapeutic strategy for treating acute organ injury.}, archive = {J_ADVS}, author = {Guotao Lu and Fei Han and Yaodong Wang and Chenchen Yuan and Qingtian Zhu and Tianqi Xia and Lin Chen and Xiaowu Dong and Yanbing Ding and Weiming Xiao and Yuyan Zhang and Jiajia Pan and Hongwei Xu and Weiwei Chen and Bo Tu and Wei Li and Fei Wang and Weijuan Gong and Lianghao Hu}, doi = {10.1002/advs.202506028}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e06028}, shortjournal = {Adv. Sci.}, title = {Src reduces neutrophil extracellular traps generation and resolves acute organ damage}, volume = {12}, year = {2025}, }
• (2025). Nanocatalytic neuroprotection and neurological recovery post-traumatic brain injury. ADVS, 12(41), e05962. (www)

  @article{ , abstract = {Traumatic brain injury (TBI) is a severe neurological disorder requiring novel therapeutic strategies. We developed ultrasmall catalytic Ce 0.7 Zr 0.3 O 2 nanozymes (CZs) and investigated their neuroprotective potential in combination with nimodipine, a calcium channel blocker. CZs effectively alleviated oxidative stress but were insufficient against calcium-mediated neuronal injury, while nimodipine alone inadequately mitigated oxidative damage. Combined therapy preserved blood–brain barrier integrity, reduced oxidative stress and neuroinflammation, and inhibited neuronal apoptosis, with CZs exerting potent effects even at low doses. Nimodipine synergistically regulated calcium overload, suppressed CaMKII activation, and enhanced functional recovery during later TBI stages. Notably, nimodipine promoted preferential accumulation of CZs in injured brain tissue, further amplifying neuroprotection. Behavioral and histological analyses confirmed significant improvements in cognitive and motor outcomes, indicating superior efficacy of the combined treatment over either agent alone. These findings highlight a promising strategy integrating nanozyme-based antioxidative therapy with calcium channel blockade for comprehensive TBI management, offering translational potential for clinical application.}, archive = {J_ADVS}, author = {Xinjie Hong and Liang Zhao and Xianzheng Sang and Chao Ma and Meiqi Chang and Xinran Song and Wei Feng and Tao Xu and Li Ding and Yu Chen and Lijun Hou}, doi = {10.1002/advs.202505962}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05962}, shortjournal = {Adv. Sci.}, title = {Nanocatalytic neuroprotection and neurological recovery post-traumatic brain injury}, volume = {12}, year = {2025}, }
• (2025). Biomimetic thermal safety strategies in batteries for electric vehicles: From biological principles to engineering approaches. ADVS, 12(41), e05882. (www)

  @article{ , abstract = {With the rapid development of renewable energy and the widespread adoption of electric vehicles, thermal runaway (TR) in batteries has become a critical safety concern. Despite various protective technologies, TR remains frequent due to challenges in metal dendrite growth, material stability, and efficient thermal management. Inspired by natural structures and functions, biological principles have been abstracted to guide novel biomimetic approaches. This review focuses on TR mechanisms, summarizes the corresponding biomimetic principles, and discusses their applications in functional design strategies to enhance battery safety and stability. First, the review outlines current TR protection designs from both intrinsic and system safety perspectives, analyzing biomimetic strategies to enhance intrinsic safety by improving the thermal stability of battery components to reduce the risk of TR. Next, it explores the application of biomimetic designs in thermal management and protection mechanisms, including innovations in thermal management and structure. Finally, this review consolidates the findings from the preceding sections on biomimetic designs for TR protection, emphasizing current challenges and potential future directions, to offer new technical insights and guidance for research on thermal safety in batteries.}, archive = {J_ADVS}, author = {Weifeng Li and Zhongchun Wang and Yao Xue and Zhenhai Gao and Huanli Sun and Ximin Zhai and Deping Wang and Yupeng Chen}, doi = {10.1002/advs.202505882}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05882}, shortjournal = {Adv. Sci.}, title = {Biomimetic thermal safety strategies in batteries for electric vehicles: From biological principles to engineering approaches}, volume = {12}, year = {2025}, }
• (2025). Identifying tipping points during healthy brain aging through single-nucleus transcriptomic analysis. ADVS, 12(41), e05779. (www)

  @article{ , abstract = {Brain aging significantly impairs cognitive and behavioral functions. While some nonlinear aging studies have identified age-specific aging peaks at certain ages, the influence of different cell types on brain aging fluctuations across the lifespan remains unclear. This study, approaching from the interdisciplinary perspective of brain aging and systems dynamics, extends the nonlinear aging analysis to the cellular level, using single-cell transcriptomic data to analyze 45 healthy elderly brain samples aged 29–94 years. Describing cellular and molecular differences in the aging process, neuron proportion is downregulated but relatively stable with low variability after aging, while glial cells are significantly upregulated and highly unstable. Notably, peaks in nonlinear molecular fluctuations are observed in aging at ages 60, 70, and 79. The nonlinear features prompted the introduction of a dynamic network biomarker and the identification of 56–60 years as the tipping point in the brain's healthy aging process, then suggesting that glia predominantly mediate this process and exploring the underlying features and mechanisms. This work investigates the tipping point of aging at single-cell resolution and provides new research strategies for early diagnosis and intervention of aging-related neurological diseases.}, archive = {J_ADVS}, author = {Peiru Wu and Xuyu Zhao and Zixin Chen and Jingying Huang and Tengteng Dai and Jianxin Zhou and Luyao Xiao and Luonan Chen and Robert Chunhua Zhao and Jiao Wang}, doi = {10.1002/advs.202505779}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05779}, shortjournal = {Adv. Sci.}, title = {Identifying tipping points during healthy brain aging through single-nucleus transcriptomic analysis}, volume = {12}, year = {2025}, }
• (2025). Megasphaera elesdenii dysregulates colon epithelial homeostasis, aggravates colitis-associated tumorigenesis. ADVS, 12(41), e05670. (www)

  @article{ , abstract = {Altered gut microbiota has evidenced to be associated with colitis and colonic tumorigenesis, however bacteria-driven mechanism underlying inflammation-related colon pathologies remains undetermined. This study identifies a previously overlooked genus, Megasphaera , is highly abundant in inflammatory bowel diseases (IBD) and colorectal cancer (CRC) cohorts. A Megasphaera species, M. elsdenii reshapes colonic immunity by triggering dendritic cell (DC)-mediated Th1 and Th17 inflammation. Mechanistically, M. elsdenii and its lipopolysaccharide triggers DC activation via TLR4/NF-κB/IRF4 pathway. Accordingly, in Tlr4 −/− mice, M. elsdenii colonization cannot expand colonic infiltration of DCs and fails to induce Th1 and Th17 responses in. In a Shanghai CRC cohort with a 100% detective rate for Megasphaera , the species of Megasphaera significantly dominated in early onset CRC patients (<50 years old) rather than late-onset CRC (≥50 years old). M. elsdenii and M. elsdenii -enriched microbiota exacerbate colonic inflammation and tumorigenesis in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced murine colitis-associated cancer model. Taken together, this study uncovers a pathogenic role of Megasphaera in developing colonic tumorigenesis via activating DC-mediated inflammation.}, archive = {J_ADVS}, author = {Xinxin Hou and Zhaozhou Zhang and Wanqing Chen and Jinming Li and Xiangxiang Zhu and Mingjie Li and Xiaoqi Guan and Haidong Guo and Yanlei Ma and Ling Zhao}, doi = {10.1002/advs.202505670}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05670}, shortjournal = {Adv. Sci.}, title = {Megasphaera elesdenii dysregulates colon epithelial homeostasis, aggravates colitis-associated tumorigenesis}, volume = {12}, year = {2025}, }
• (2025). Water, collagen, and lipid content in the human skin and muscles assessed with near-infrared diffuse reflectance spectroscopy and multi-spectral optoacoustic tomography. ADVS, 12(41), e05619. (www)

  @article{ , abstract = {Infrared spectroscopy can quantify individual body components such as lipids, water, and proteins, but extending it to a comprehensive assessment of overall body composition is hampered by high variability and optical heterogeneity of biological tissues. Here, a theoretical and experimental strategy merging multi-spectral optoacoustic tomography (MSOT) and diffuse reflectance spectroscopy (DRS) is introduced to characterize skin and subcutaneous tissue composition in the near-infrared range. Water, lipids, and collagen exhibit distinct absorption peaks, with lipids demonstrating significantly higher absorption than collagen at comparable mass concentrations. Diminished lipid absorption in subjects with thin hypodermis allows the DRS method to detect distinct collagen band at 910 nm, whose magnitude correlates with the muscle mass, as confirmed by bioimpedance analysis. Conversely, strong lipid peak at 930 nm in subjects with pronounced hypodermis overshadows collagen signals by an order of magnitude, making DRS characterization insufficient. MSOT overcomes this limitation by offering high-resolution depth-resolved 3D imaging to accurately delineate the dermis, hypodermis, and muscle layers in vivo and quantify each chromophore's contribution individually. The findings demonstrate the complementary capabilities of MSOT and DRS for molecularly specific, noninvasive body composition analysis, potentially enhancing diagnostic approaches for a number of conditions, such as obesity and sarcopenia.}, archive = {J_ADVS}, author = {Denis Davydov and Alexey Kurnikov and Pavel Subochev and Gleb Budylin and Nikolay Fadeev and Ivan Filippov and Natalia Mokrysheva and Liliya Urusova and Daniel Razansky and Evgeny Shirshin}, doi = {10.1002/advs.202505619}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05619}, shortjournal = {Adv. Sci.}, title = {Water, collagen, and lipid content in the human skin and muscles assessed with near-infrared diffuse reflectance spectroscopy and multi-spectral optoacoustic tomography}, volume = {12}, year = {2025}, }
• (2025). Tead1a initiates transcriptional priming through the TEAD1a/YAP-notch1-Spi1/Cebpα axis to promote neutrophil fate. ADVS, 12(41), e05441. (www)

  @article{ , abstract = {Clinical neutropenia, a blood disorder marked by faulty neutrophil production, resists effective treatment due to developmental bottlenecks in granulopoiesis. While the current therapy, such as granulocyte colony-stimulating factor (G-CSF), boosts neutrophil counts, its late-stage action mobilizes dysfunctional cells, underscoring the need for early-lineage therapeutic interventions. Leveraging zebrafish models, we found that transcriptional enhanced associate domain 1a (TEAD1a) initiates transcriptional priming to govern neutrophil lineage specification preceding hematopoietic stem cell formation. Genetic ablation of TEAD1a or disruption of its interaction with Yes-associated protein 1 (YAP1) induces profound neutropenia. Mechanistic interrogation reveals that TEAD1a/YAP1 complexes potentiate Notch1-mediated signaling to activate a Spi1/Cebpα transcriptional cascade during myeloid progenitor specification. This study uncovers a novel developmental regulatory window for myeloid lineage commitment and demonstrates the evolutionarily conserved role of TEAD1a-mediated transcriptional priming in orchestrating neutrophil development. The discovery of this ultra-early regulatory node provides a molecularly defined target for generating developmentally competent neutrophils, offering an innovative therapeutic strategy for refractory neutropenia.}, archive = {J_ADVS}, author = {Wang Yiqin and Yang Ruimeng and Wang Peihong and Liu Xiaohui and Yuan Hao and Huang Hongli and Zhou Yongjian and Xie Baoshu}, doi = {10.1002/advs.202505441}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05441}, shortjournal = {Adv. Sci.}, title = {Tead1a initiates transcriptional priming through the TEAD1a/YAP-notch1-Spi1/Cebpα axis to promote neutrophil fate}, volume = {12}, year = {2025}, }
• (2025). Confocal absorbance-activated droplet sorting (cAADS) for enzyme engineering. ADVS, 12(41), e05324. (www)

  @article{ , abstract = {Directed evolution relies on iterative cycles of variant generation, screening, and selection to identify enzyme variants with improved activities. Droplet-based microfluidics accelerates this process by enabling rapid screening of enzyme variants in water-in-oil emulsions acting as picoliter-scale microcompartments. In fluorescence-activated droplet sorting (FADS), single E.coli cells are screened using a fluorogenic substrate at high throughput (≈2 kHz). However, fluorogenic assays for enzymatic systems are limited, while absorbance-based detection assays represent a larger spectrum. At the micron scale, light absorption is weak, and scattering induced by droplet interfacial curvature further decreases detection sensitivity. Measurements are therefore performed at a cost of increasing droplet sizes or acquisition times, which limits throughput to <1 kHz. Here, this challenge is addressed with a confocal Absorbance-Activated Droplet Sorting (cAADS) system. The platform achieves sensitive absorbance measurements at ultrahigh throughput (5.4 kHz) from droplets as small as 10 pL, and sorting of 50 pL droplets at frequencies up to 2.6 kHz. The cAADS methodology is demonstrated by enrichment of active Bilirubin Oxidase (BOD) variants, with a sorting efficiency of 99%. Its versatility and potential for absorbance-based microfluidic screening in enzyme engineering are also demonstrated using a different enzyme: Glucose Oxidase.}, archive = {J_ADVS}, author = {Abdi Mirgissa Kaba and Sébastien Gounel and Thomas Beneyton and Lionel Buisson and Jean-Christophe Baret and Nicolas Mano}, doi = {10.1002/advs.202505324}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05324}, shortjournal = {Adv. Sci.}, title = {Confocal absorbance-activated droplet sorting (cAADS) for enzyme engineering}, volume = {12}, year = {2025}, }
• (2025). Igfbp2 downregulation in PVT-CeA glutamatergic circuits drives neonatal anesthesia-induced fear memory deficits. ADVS, 12(41), e05025. (www)

  @article{ , abstract = {Repeated neonatal general anesthesia results in long-term cognitive dysfunction; however, the underlying mechanisms remain unclear. This study finds that repeated neonatal anesthesia impaired fear memory in adolescent mice of both sexes, along with hypoactivated glutamatergic neurons in the paraventricular thalamus (PVT). Optogenetic activation of PVT glutamatergic neurons rescued fear memory deficits in anesthesia-treated mice, whereas optogenetic inhibition of these neurons recapitulated memory deficits in control mice. Specifically, repeated neonatal anesthesia reduced insulin-like growth factor-binding protein 2 (Igbp2) expression and dendritic spine density in PVT glutamatergic neurons in both males and females. Selectively manipulating PVT glutamatergic Igfbp2 mediated anesthesia-induced fear memory deficits through modulating neuron excitability and spine density. Notably, optogenetic activation or restoring Igfbp2 expression in glutamatergic projections from the PVT to the central amygdala (CeA) blocked anesthesia-induced memory impairment, whereas optogenetic inhibition or knocking down of Igfbp2 expression in these projections is sufficient to engender similar memory impairment in control mice. The findings demonstrate that Igfbp2 in glutamatergic neurons in the PVT afferents to the CeA mediates fear memory deficits caused by repeated neonatal anesthesia in mice of both sexes, highlighting Igfbp2 as a potential therapeutic target for repeated anesthesia-induced cognitive impairment.}, archive = {J_ADVS}, author = {Weiming Zhao and Ke Peng and Baojian Zhao and Xiaowen Meng and Gang Wang and Hanbing Xu and Li Deng and Xisheng Shan and Yichan Wang and Qiya Xu and Yanan Gao and Ruixia Weng and Hong Liu and Jin Tao and Huayue Liu and Shaoyong Song and Fuhai Ji}, doi = {10.1002/advs.202505025}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05025}, shortjournal = {Adv. Sci.}, title = {Igfbp2 downregulation in PVT-CeA glutamatergic circuits drives neonatal anesthesia-induced fear memory deficits}, volume = {12}, year = {2025}, }
• (2025). SCRIPT: Predicting single-cell long-range cis-regulation based on pretrained graph attention networks. ADVS, 12(41), e05021. (www)

  @article{ , abstract = {Single-cell cis-regulatory relationships (CRRs) are essential for deciphering transcriptional regulation and understanding the pathogenic mechanisms of disease-associated non-coding variants. Existing computational methods struggle to accurately predict single-cell CRRs due to inadequately integrating causal biological principles and large-scale single-cell data. Here, SCRIPT (Single-cell Cis-regulatory Relationship Identifier based on Pre-Trained graph attention networks) is presented for inferring single-cell CRRs from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas-scale single-cell chromatin accessibility data. Validation using cell-type-specific chromatin contact and CRISPR perturbation data demonstrates that SCRIPT achieves a mean AUC of 0.89, significantly outperforming state-of-the-art methods (AUC: 0.7). Notably, SCRIPT obtains an over twofold improvement in predicting long-range CRRs (>100 Kb) compared to existing methods. By applying SCRIPT to Alzheimer's disease and schizophrenia, a framework is established for prioritizing disease-causing variants and elucidating their functional effects in a cell-type-specific manner. By uncovering molecular genetic mechanisms undetected by existing computational methods, SCRIPT provides a roadmap for advancing genetic diagnosis and target discovery.}, archive = {J_ADVS}, author = {Yu Zhang and Baole Wen and Yifeng Jiao and Yuchen Liu and Xin Guo and Yushuai Wu and Jiyang Li and Limei Han and Yinghui Xu and Xin Gao and Yuan Qi and Yuan Cheng and Ying He and Weidong Tian}, doi = {10.1002/advs.202505021}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e05021}, shortjournal = {Adv. Sci.}, title = {SCRIPT: Predicting single-cell long-range cis-regulation based on pretrained graph attention networks}, volume = {12}, year = {2025}, }
• (2025). Storage potential of soil functional carbon fractions in the world's largest plantations. ADVS, 12(41), e04995. (www)

  @article{ , abstract = {The expansion of planted forests is one of the most effective natural climate solutions. However, increasing forest age and climate change lead to weaken biomass carbon sink, highlighting the urgency of improving the storage of functional soil organic carbon (SOC) to maintain a high level of carbon sink on a long-time scale. Using data from 501 planted forests and 564 natural forests across China, it is found that climate warming and drying increase the loss of topsoil (0–20 cm) mineral-associated (MAOC) and particulate organic carbon (POC) during the conversion of natural forests to plantations. High-precision random forest models for MAOC (77%) and POC (75%) derive the storage of the functional SOC in planted and natural forests. The total deficit of SOC in plantations compared to natural forests is Pg SOC (mean with 5% and 95% quantile). This substantial potential can be gained by plantation management, such as close-to-nature management. The minimal (14.61 Pg C), intermediate (22.36 Pg C), and ambitious (29.79 Pg C) objectives of SOC storage potential, providing science-based targets for enhancing soil carbon sinks, are also estimated. Overall, these findings provide a transferable framework to assess functional SOC benchmarks and targets for policymakers and highlight the strategic role of plantation soils for global carbon neutrality goals.}, archive = {J_ADVS}, author = {Siyu Ren and Hui Wang and Tao Zhou and Chuankuan Wang and Zhenghu Zhou and Shirong Liu}, doi = {10.1002/advs.202504995}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e04995}, shortjournal = {Adv. Sci.}, title = {Storage potential of soil functional carbon fractions in the world's largest plantations}, volume = {12}, year = {2025}, }
• (2025). SIRT6 lysine-demyristoylates ATF2 to ameliorate vascular injury via PRKCD/VE-cadherin pathway regulating vascular endothelial barrier. ADVS, 12(41), e04948. (www)

  @article{ , abstract = {Cardiovascular diseases (CVDs) progression is significantly modulated by epigenetic mechanisms, particularly through Sirtuin 6 (SIRT6), a key NAD⁺-dependent deacetylase in the sirtuin family. Though essential for cardiovascular homeostasis, the effects of SIRT6-mediated lysine myristoylation on CVDs progression remain largely unexplored due to detection limitations. This study developes an innovative lysine-myristoylated peptide enrichment technique, identifying mutant SIRT6 (H133Y) with high myristoyl affinity but deficient demyristoylase activity. This advancement enables identification of 15 previously unrecognized human lysine-myristoylated proteins. Further study demonstrates that SIRT6 demyristoylates activating transcription factor 2 (ATF2) at K296 and regulates its nucleoplasmic translocation. Through 4D label-free mass spectrometry and molecular approaches, it is revealed that decreased nuclear localization of ATF2 results in reduced Protein kinase C delta type (PRKCD) expression, establishing a SIRT6/Myr-ATF2/PRKCD/VE-Cadherin pathway that enhances endothelial barrier integrity under high myristate conditions. These findings are validated in vitro (gene overexpression/knockdown cells) and in vivo (SIRT6 knockout/double-transgenic mice). The study provides both a novel method for identifying lysine-myristoylated proteins and critical insights into SIRT6 demyristoylation biology. Modulating the SIRT6 pathway might yield therapies to strengthen endothelial integrity and mitigate vascular dysfunction in CVDs, offering promising clinical translation avenues.}, archive = {J_ADVS}, author = {Runyang Feng and Zheyan Fang and Shuang Zhao and You-en Zhang and Na Wu and Zhenyang Guo and Xin Zhong and Bixuan Jiang and Hongfei Xu and Hangnan Hong and Zhentao Zhang and Mukaddas Abdurahman and Xueting Yu and Jilong Geng and Xiansu Nie and Supuya Abuduwahapi and Dong Huang and Gang Zhao and Wenbin Zhang and Hao Lu and Li Shen and Xin Zhao and Zhaoyang Chen and Junjie Guo and Hongchao Zheng and Yue He and Sanwu Wu and Jiayin Peng and Jiawen Song and Xiao Wang and Haomin Li and Yuli Huang and Shengying Qin and Haojie Lu and Xiangdong Wang and Jianguo Zhao and Lei Huang and Yun Zhao and Peng Li and Junbo Ge and Hua Li}, doi = {10.1002/advs.202504948}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e04948}, shortjournal = {Adv. Sci.}, title = {SIRT6 lysine-demyristoylates ATF2 to ameliorate vascular injury via PRKCD/VE-cadherin pathway regulating vascular endothelial barrier}, volume = {12}, year = {2025}, }
• (2025). Lactylation of HMGB1 at k177 drives nuclear export of TIAR to promote hypoxia-induced stress granule formation. ADVS, 12(41), e04896. (www)

  @article{ , abstract = {HMGB1, one of the most abundant nuclear non-histone proteins, also performs extracellular functions, and its nuclear export mechanisms have been extensively studied. Here, a novel mechanism of nuclear export for HMGB1 driven by lactylation is proposed. In addition, it is revealed that hypoxia-induced lactylation of HMGB1 facilitates its nuclear export in a complex with TIAR, promoting stress granule (SG) formation in the cytosol. Mass spectrometry revealed 12 lysine residues in HMGB1 undergoing lactylation, with K172 and K177 being the most susceptible. Functional studies using lysine-to-arginine mutants (K→R) demonstrated that lactylation at K177 is crucial for HMGB1-TIAR complex export, as K177R mutation completely blocked this export and subsequent SG formation. Notably, this lactylation-mediated mechanism is specific to hypoxic stress, while other stressors, such as sodium arsenite exposure and heat shock, triggered TIAR nuclear export and SG assembly independently of HMGB1. These findings reveal a previously unrecognized role of HMGB1 lactylation in mediating nuclear export and SG formation under hypoxia.}, archive = {J_ADVS}, author = {Chengyu Li and Zhaojun Liu and Linjie Zhu and Gang Wu and Chen Fu and Hongmin Li and Tong He and Ming Shen and Honglin Liu}, doi = {10.1002/advs.202504896}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e04896}, shortjournal = {Adv. Sci.}, title = {Lactylation of HMGB1 at k177 drives nuclear export of TIAR to promote hypoxia-induced stress granule formation}, volume = {12}, year = {2025}, }
• (2025). Glabridin-Gold(I) complex as a novel immunomodulatory agent targeting TrxR and MAPK pathways for synergistic enhancement of antitumor immunity. ADVS, 12(41), e04729. (www)

  @article{ , abstract = {Metal-based drugs have been utilized as immunomodulatory agents in combination with cancer immunotherapies to induce tumor immunogenicity. However, the immunosuppressive tumor microenvironment significantly hinders the efficacy of these immunomodulatory agents from promoting antitumor immune responses. Herein, a novel metal-based immunomodulatory agent, 6d , is developed by integrating N -heterocyclic carbene gold(I) [NHC-Au(I)] with the natural product glabridin (GLA). Complex 6d aims to promote tumor immunogenicity while suppressing immunosuppression, by targeting thioredoxin reductase (TrxR) and the mitogen-activated protein kinase (MAPK) pathways. Notably, 6d enhances dendritic cell (DC) maturation while reducing myeloid-derived suppressor cells (MDSCs), M2-type macrophages, and regulatory T cells (Tregs) in liver cancer. Moreover, 6d exhibits a synergistic effect of gold center and GLA, suppressing programmed cell death 1 ligand 1 (PD-L1) expression in tumor cells while promoting granzyme B (GzmB) production in T cells. These findings suggest that dual inhibition of TrxR and MAPK may provide a synergistic strategy to stimulate antitumor immunity while mitigating the immunosuppressive tumor microenvironment. Overall, this study warrants further researches to determine therapeutic efficacy of 6d as an immunomodulatory agent in combination with cancer immunotherapies.}, archive = {J_ADVS}, author = {Zhaoran Wang and Meiyu Wang and Qiong Chen and Mengshi Wang and Fuwei Li and Lin Lv and Zhenfan Wen and Zhongren Xu and Yixia Yang and Chunyang Bi and Wukun Liu}, doi = {10.1002/advs.202504729}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e04729}, shortjournal = {Adv. Sci.}, title = {Glabridin-Gold(I) complex as a novel immunomodulatory agent targeting TrxR and MAPK pathways for synergistic enhancement of antitumor immunity}, volume = {12}, year = {2025}, }
• (2025). Microwave-activated bacterial biorobot for multimodal cancer therapy. ADVS, 12(41), e04603. (www)

  @article{ , abstract = {Advances in synthetic biology have enabled innovative strategies for cancer therapy, yet precise control of therapeutic expression and biosafety remain critical challenges. To address these issues, a bacterial hybrid biorobot is developed using Escherichia coli (MG1655) engineered for localized activation by microwaves. Upon activation, the biorobot expresses glucose oxidase (GOx) at tumor sites, leading to glucose depletion and hydrogen peroxide generation. Surface-attached Cu 2 O nanoparticles catalyze this hydrogen peroxide through a Fenton-like reaction, producing reactive oxygen species that drive multiple forms of tumor cell death, including apoptosis, ferroptosis, and cuproptosis. Comprehensive in vitro and in vivo studies confirm the efficacy of this approach, while transcriptomic analysis reveals disruption of glucose metabolism and robust activation of antitumor immune responses. This work demonstrates the potential of this engineered bacterial platform as a safe and versatile tool for precise, multimodal cancer treatment.}, archive = {J_ADVS}, author = {Huilan Zhuang and Yongjian Zhang and Yajuan Fu and Dangjin Ke and Qi Chen and Sijie Shao and Panpan Xue and Yuanchun Chen and Xuemei Zeng and Shuangqian Yan}, doi = {10.1002/advs.202504603}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e04603}, shortjournal = {Adv. Sci.}, title = {Microwave-activated bacterial biorobot for multimodal cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Polyadenylation complex CFII recognizes downstream cis-element for pre-mRNA polyadenylation through interaction with an RNA-binding protein in arabidopsis. ADVS, 12(41), e04562. (www)

  @article{ , abstract = {Alternative polyadenylation of pre-mRNA generates mRNAs with alternative 3′ ends, thereby increasing the complexity of the transcriptome and proteome. This process is carried out by pre-mRNA 3′ end processing complexes, with the specificity and site selection of polyadenylation primarily defined by the interaction between these complexes and conserved pre-mRNA cis-elements. However, the cis-element recognized by the polyadenylation CFII complex and the downstream cis-element of the poly(A) site remain unknown. Here, FPA, a conserved Spen family RNA-binding protein, is identified to physically interacts with the CFII complex in Arabidopsis . FPA specifically binds to a GA-rich cis-element downstream of the proximal poly(A) site, which is required for the CFII complex to promote proximal poly(A) site usage and prevent 3′ extension. Thus, the CFII complex recognizes the downstream cis-element of the poly(A) site through its interaction with FPA, highlighting the role of RNA-binding proteins as accessory factors in alternative polyadenylation.}, archive = {J_ADVS}, author = {Ying Cao and Ying Guo and Zhibo Yu and Huajian Nie and Jing Yang and Dingfu Qiu and Qiyu Li and Xu Xin and Chang Cheng and Yan Li and Xudong Shang and Yuling Jiao and Qingshun Quinn Li and Ligeng Ma}, doi = {10.1002/advs.202504562}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e04562}, shortjournal = {Adv. Sci.}, title = {Polyadenylation complex CFII recognizes downstream cis-element for pre-mRNA polyadenylation through interaction with an RNA-binding protein in arabidopsis}, volume = {12}, year = {2025}, }
• (2025). PCSK9 loss-of-function disrupts cellular microfilament network via LIN28A/HES5/JMY axis in neural tube defects. ADVS, 12(41), e04291. (www)

  @article{ , abstract = {Neural tube defects (NTDs) are complex multigenic disorders and are the most prevalent and severe congenital malformations that affect the central nervous system. PCSK9 is identified as a molecular marker for the prenatal diagnosis of NTDs during its early stages in fetuses; however, its role in NTD neurulation and pathogenesis remains unclear. This study introduces PCSK9 knockout embryonic stem cells (ESCs) into neural organoid (NO) and neural progenitor cell (NPC) models and finds that PCSK9 loss leads to an incomplete neural tube structure in NOs and microfilament network disorder in NPCs. Transcriptome sequencing analysis shows that PCSK9 loss induces NTDs via the key molecule JMY. JMY overexpression in a zebrafish model increased the incidence and severity of PCSK9 loss-associated NTDs. Mechanistically, PCSK9 acts as a molecular chaperone that promotes LIN28A degradation via the lysosomal pathway. LIN28A is an RNA-binding protein that affects JMY expression by regulating the transcription factor HES5. Thus, PCSK9 loss disrupts the cellular microfilament network via the LIN28A/HES5/JMY axis, leading to NTDs. These findings provide important insights into the pathogenesis and therapeutics of NTDs.}, archive = {J_ADVS}, author = {Xiaoshuai Li and Rui Wang and Wenting Luo and Hui Gu and Tianchu Huang and Qiushi Wang and Zhengwei Yuan}, doi = {10.1002/advs.202504291}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e04291}, shortjournal = {Adv. Sci.}, title = {PCSK9 loss-of-function disrupts cellular microfilament network via LIN28A/HES5/JMY axis in neural tube defects}, volume = {12}, year = {2025}, }
• (2025). Implantable ion-selective organic electrochemical transistors enable continuous, long-term, and in vivo plant monitoring. ADVS, 12(41), e04283. (www)

  @article{ , abstract = {The development of plant-specific biosensors holds the potential to uncover new insights into plant physiology and advance precision agriculture. Current sensing platforms mainly focus on broad plant phenotypes (e.g., elongation and hydration) and local environmental monitoring (e.g., temperature and moisture). Here, an ion-selective organic electrochemical transistor (IS-OECT) is introduced that enables real-time monitoring of variations in potassium ion concentration within the xylem of pine trees. This work demonstrates that the high sensitivity of the IS-OECT enables the detection of subtle variations in potassium ion concentrations in the xylem sap of living trees, and the high stability of the sensor allows for in vivo measurements over five weeks. Furthermore, the implantable sensors are fabricated using processes that are compatible with low-cost manufacturing (i.e., lithography-free). This sensing technology, therefore, has great potential to be a game-changer in precision forestry and could extend to precision agriculture and horticulture practices.}, archive = {J_ADVS}, author = {Sanggil Han and Dalila Pasquini and Mathias Sorieul and Miguel H. Boratto and Luke Gatecliff and Alan Dickson and Suhyeon Jang and Stephanie Davy and George G. Malliaras and Yi Chen}, doi = {10.1002/advs.202504283}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e04283}, shortjournal = {Adv. Sci.}, title = {Implantable ion-selective organic electrochemical transistors enable continuous, long-term, and in vivo plant monitoring}, volume = {12}, year = {2025}, }
• (2025). The NSP5, ORF6 and NSP13 of SARS-CoV-2 cooperate to modulate inflammatory cell death activation. ADVS, 12(41), e03977. (www)

  @article{ , abstract = {Programmed cell death is a pivotal mechanism of cell-autonomous immune defense against viral infections. Recent studies indicate that both blocking and promoting cell death negatively affect coronavirus replication, implying that coronaviruses may fine-tune cell death pathways to optimize their propagation. However, the mechanisms underlying this remain poorly understood. Here, it is verified that coronaviruses induce the formation of a Z-DNA-binding protein 1 (ZBP1)-initiated cell death complex involving ZBP1, Z-RNA, receptor-interacting serine/threonine-protein kinase 3 (RIPK3), and caspase-8, thereby triggering apoptosis, pyroptosis, and necroptosis in human bronchial epithelial cells. To impede the activation of apoptosis and pyroptosis, NSP5 and ORF6 of SARS-CoV-2 concurrently inhibit caspase-8 activity by targeting its large and small subunits, respectively. Additionally, NSP13, the viral helicase, interacts with RIPK3 to impair its binding to ZBP1, thus suppressing ZBP1-initiated necroptosis. This inhibitory effect on cell death is likely conserved across β-coronaviruses. Furthermore, co-infection of influenza A virus and SARS-CoV-2 is demonstrated to exacerbate disease severity, although the mechanisms remain unclear. These findings suggest that β-coronavirus-induced inhibition of cell death enhances influenza A virus replication and worsens inflammation during their co-infection, ultimately increasing mortality in mice. This research provides valuable insights into the regulation of coronavirus-induced cell death, offering potential therapeutic strategies for combating highly pathogenic coronavirus infections.}, archive = {J_ADVS}, author = {Huan Wang and Mengdi Liang and Jing Zhang and Hua Tong and Fenfen Zhang and Ying Liu and Pui Wang and Mengmeng Chang and Fei Han and Siwen Liu and Yongping Lin and Wenjun Song and Rajendra Karki and Peihui Wang and Honglin Chen and Yang Liu and Min Zheng}, doi = {10.1002/advs.202503977}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e03977}, shortjournal = {Adv. Sci.}, title = {The NSP5, ORF6 and NSP13 of SARS-CoV-2 cooperate to modulate inflammatory cell death activation}, volume = {12}, year = {2025}, }
• (2025). Integrated ‘Shield-spear’ biological patch for fibrosis-free bladder reconstruction. ADVS, 12(41), e03975. (www)

  @article{ , abstract = {Bladder reconstruction without fibrosis remains a global challenge. Current bladder defect treatments primarily focus on repair at the level of vascularization, failing to balance healing and excessive collagen deposition, and neglecting the exacerbation of fibrosis due to neural dysregulation. In this study, an integrated ‘shield-spear’ patch composed of an anionic ‘shield’ hydrogel (HAD) and neuro-targeted ‘spear’ engineered extracellular vesicles (S100Aptamer-EVs) using Schiff base chemistry and Michael addition reactions is engineered. This novel approach represents the first attempt to synergistically balance the contradiction between fibrosis and wound healing through the ‘shield-spear’ strategy, achieving extensive bladder reconstruction without fibrosis. In a large animal model of beagles, the outer layer of the ‘shield-spear’ patch acts as an anionic shield, neutralizing scavenger receptors and selectively capturing GATA6 + peritoneal macrophages to suppress collagen overexpression. The inner layer enables the unidirectional release of S100AptEVs, targeting the activation of Schwann cells to express the brain-derived neurotrophic factor neuroprotective factor, downregulating the TGFβ/Smad fibrosis pathway, thereby collaboratively inhibiting neurogenic fibrosis and activating Cadherin signaling to promote wound healing. The integrated ‘shield-spear’ patch facilitated surgical manipulation in large animals and provides a promising approach for tissue-engineered bladder reconstruction without fibrosis.}, archive = {J_ADVS}, author = {Xiaoqi Wu and Huitong Ruan and Xiaolin Zhang and Weihan Zheng and Muhetaierjiang Mutailifu and Ling Wang and Liu Yu and Ruijun Peng and Rui Zhao and Zihan Wang and Jie Xu and Shaochuan Li and Yaobin Wu and Wenguo Cui and Mujun Lu}, doi = {10.1002/advs.202503975}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e03975}, shortjournal = {Adv. Sci.}, title = {Integrated ‘Shield-spear’ biological patch for fibrosis-free bladder reconstruction}, volume = {12}, year = {2025}, }
• (2025). M6A-modified circRAPGEF1 interaction with IGF2BP3 promotes hepatocellular carcinoma progression via reprogramming aspartate metabolism. ADVS, 12(41), e03851. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) progression and therapy sensitivity are critically fueled by liver cancer stem cells (LCSCs), yet the regulatory mechanisms of circular RNAs (circRNAs) on LCSCs remain elusive. Here, through circRNA microarray analysis of LCSCs and non-stem HCC cells, circRAPGEF1 is identified as a LCSC-enriched circRNA upregulated in HCC tissues and predictive of poor patient survival. Functionally, circRAPGEF1 promoted the stemness properties, proliferation, and tumorigenicity of HCC cells. Mechanistically, the METTL3-mediated N 6 -methyladenosine (m 6 A) modification of circRAPGEF1 facilitated KH domain-dependent binding of IGF2BP3 to its UGGAC motif, which conferring stability to circRAPGEF1 while competitively disrupting the IGF2BP3/ ASS1 mRNA interaction. This process led to the degradation of ASS1 mRNA, triggering aspartate accumulation and activation of the S6K/CAD signaling pathway. Crucially, circRAPGEF1 overexpression reduced the sorafenib sensitivity, whereas targeting circRAPGEF1 using nanoparticles-mediated systematic siRNAs delivery effectively sensitized HCC cells to sorafenib. Collectively, these findings unveil a METTL3/circRAPGEF1/IGF2BP3/ASS1 regulatory axis that drives aspartate metabolic reprogramming to fuel HCC stemness properties, positioning circRAPGEF1 as a dual prognostic biomarker and therapeutic target to enhance sorafenib efficacy in HCC.}, archive = {J_ADVS}, author = {Juanyi Shi and Sintim Mui and Yongcong Yan and Shaomin Liu and Kai Wen and Chuanchao He and Huoming Li and Hao Liao and Meng Tao and Jiahua Wen and Weidong Wang and Xiaoding Xu and Zhenyu Zhou and Zhiyu Xiao}, doi = {10.1002/advs.202503851}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e03851}, shortjournal = {Adv. Sci.}, title = {M6A-modified circRAPGEF1 interaction with IGF2BP3 promotes hepatocellular carcinoma progression via reprogramming aspartate metabolism}, volume = {12}, year = {2025}, }
• (2025). Targeting multilayered metabolic networks in brain diseases: Emerging perspectives on nanodelivery strategies. ADVS, 12(41), e03645. (www)

  @article{ , abstract = {Brain metabolism is uniquely regulated, and alterations in its metabolic networks often serve as critical drivers of the onset and progression of brain diseases. Therapeutic strategies that target these metabolic changes are regarded as fundamental to disease intervention. In complex metabolic networks, multi-level metabolic dysregulation typically initiates a shared pathological process: the disruption of core cell metabolism leads to impaired cell–cell interactions, ultimately promoting the development of a malignant microenvironment that supports disease progression. This process encompasses complex mechanisms such as substance transport, cell signaling, and the dynamic regulation of the microenvironment. Smart nanodelivery systems, with their versatility, responsiveness, and modularity, can precisely modulate these dynamic metabolic networks in brain diseases, guided by the underlying pathological mechanisms. In this review, the metabolic network characteristics associated with brain diseases is summarized and the use of nanodelivery systems and their combinations are explored for metabolic regulation, aiming to establish a novel therapeutic paradigm.}, archive = {J_ADVS}, author = {Jingyi Zhou and Chen Jiang}, doi = {10.1002/advs.202503645}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e03645}, shortjournal = {Adv. Sci.}, title = {Targeting multilayered metabolic networks in brain diseases: Emerging perspectives on nanodelivery strategies}, volume = {12}, year = {2025}, }
• (2025). Deciphering the role and mechanism of decidual monocyte-derived macrophage infiltration in obstetric antiphospholipid syndrome at single-cell resolution. ADVS, 12(41), e03480. (www)

  @article{ , abstract = {Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disorder characterized by pathologic pregnancies and the presence of antiphospholipid antibodies (aPLs). Despite significant infiltration of decidual macrophages observed in OAPS patients, the underlying connections between decidual and peripheral immune cells remain unclear. In this study, an integrated single-cell atlas is constructed of the decidua and peripheral blood mononuclear cells (PBMCs) from OAPS patients and HCs. Using this atlas, substantial disparities are identified in immune cells between the decidua and PBMCs. The functional changes in immune cells of OAPS patients are also different in decidua and PBMCs. Moreover, increased infiltration of monocyte-derived macrophages (MDMs) into the decidua is found to contribute to inflammation and trophoblast dysfunction in OAPS. The role of CCL2 is further discovered in recruiting MDMs, driven by excess CCL2 secreted from decidual macrophages stimulated by the aPLs and β 2 -glycoprotein I complex via the TLR4-NF-κB pathway. Decidual vascular endothelial cells express higher levels of ACKR1, which aggregates CCL2 on their surface. Targeting CCR2 and TLR4 improved pregnancy outcomes in OAPS mouse models induced by aPLs, suggesting that these pathways may serve as potential therapeutic targets for OAPS. This study provides new insights into the pathogenesis of OAPS, particularly regarding decidual MDMs infiltration.}, archive = {J_ADVS}, author = {Rui Gao and Pingying Qing and Hanxiao Chen and Zhengyan Hu and Qiaoran Yang and Chenyang Lu and Huimin Liu and Rujun Zeng and Yuanting Tang and Fan Yu and Jinbiao Han and Xin Liao and Xun Zeng and Lang Qin}, doi = {10.1002/advs.202503480}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e03480}, shortjournal = {Adv. Sci.}, title = {Deciphering the role and mechanism of decidual monocyte-derived macrophage infiltration in obstetric antiphospholipid syndrome at single-cell resolution}, volume = {12}, year = {2025}, }
• (2025). A study on the cell layer patterns of a citrus periclinal chimera reveals β-cryptoxanthin regulation in citrus fruits. ADVS, 12(41), e03177. (www)

  @article{ , abstract = {As a dietary provitamin A carotenoid, β-cryptoxanthin is more bioavailable than common carotenoids. However, β-cryptoxanthin is a minor carotenoid in most crops, except for certain citrus species. A chimera (OCC) is identified, which grows from the graft junction between mandarin (OOO) and grapefruit (CCC), and it exhibits a unique β-cryptoxanthin profile. OCC is a periclinal chimera with the L1 cell layer from OOO and L2 and L3 layers from CCC. The flavedo, pulp, and segment membranes of OCC are generated from all three cell layers, but the proportions of these cell layers differ; OOO:CCC (L1:L2/L3) is ≈1:4 in the flavedo, 1:1 in the pulp, and 1:3 in the segment membrane. A nucleus-localized transcriptional activator, MYB107 , is identified, which regulates β-cryptoxanthin variation between OCC and its donors. MYB107 expression is closely associated with β-cryptoxanthin accumulation, and its overexpression in citrus calli and fruits enhance carotenoid biosynthesis and upregulate carotenogenic genes, whereas MYB107 expression interference demonstrates the opposite effects. MYB107 directly binds to and activates the promoters of β-carotene hydroxylase ( BCH ), positively regulating β-cryptoxanthin biosynthesis. These findings provide new insights into β-cryptoxanthin accumulation patterns in citrus, highlighting the potential to improve the nutritional and aesthetic value of citrus fruits.}, archive = {J_ADVS}, author = {Chi Zhang and Kaijie Zhu and Zhehui Zhang and Huiyu Ji and Qun Wu and Lin Zhang and Fuzhi Ke and Gang Wang and Min Zhang}, doi = {10.1002/advs.202503177}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e03177}, shortjournal = {Adv. Sci.}, title = {A study on the cell layer patterns of a citrus periclinal chimera reveals β-cryptoxanthin regulation in citrus fruits}, volume = {12}, year = {2025}, }
• (2025). A prion-like domain in EBV EBNA1 promotes phase separation and enables SRRM1 splicing. ADVS, 12(41), e01977. (www)

  @article{ , abstract = {Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is necessary to maintain stability of EBV episomes, EBV replication, and causes host genomic instability and promotes tumor cells survival. Recent studies have shown that viruses utilize liquid–liquid phase separation (LLPS) within host cells to form sub-cellular compartments known as “virus factories”. Prion-like domains (PrLDs), which resemble structural domains of low complexity, are shown to drive LLPS in vivo. In the current study, a PrLD is identified in EBNA1 and aggregation of EBNA1 proteins is observed in EBV-positive tumors. EBNA1 condensate interacting molecules are examined and are found that EBNA1 interacts with the splicing factor SRSF1 to regulate alternative splicing of SRRM1 and promote tumor progression. Deleting the EBNA1 PrLD results in defects in protein aggregation, LLPS, alternative splicing regulation, and nasopharyngeal carcinoma cells proliferation. Targeting the PrLD of EBNA1 inhibits the formation of protein aggregation, promotes alternative splicing of SRRM1, and inhibits the progression of nasopharyngeal carcinoma. Here, we report for the first time that EBNA1, a protein from the human oncogenic virus EBV, is a prion-like protein, combining algorithm prediction and experimental validation. That implies a possible molecular pathogenic mechanism of EBNA1 in neurodegenerative diseases.}, archive = {J_ADVS}, author = {Xiaoyue Zhang and Zhengshuo Li and Run Zheng and Xiang Zheng and Jia Wang and Can Liu and Yangge Wu and Yuqing Wen and Chunlin Ou and Songqing Fan and Chenxiao Xu and Junrui Tian and Qun Yan and Hao Nan and Xiaodong Xu and Hui Wang and Qiu Peng and Jian Ma}, doi = {10.1002/advs.202501977}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e01977}, shortjournal = {Adv. Sci.}, title = {A prion-like domain in EBV EBNA1 promotes phase separation and enables SRRM1 splicing}, volume = {12}, year = {2025}, }
• (2025). Melatonin modulates glucose metabolism reprogramming via targeting G6PD to alleviate lead-induced hepatocytes pyroptosis in common carp (Cyprinus carpio l.). ADVS, 12(41), e01041. (www)

  @article{ , abstract = {Lead (Pb) is a prevalent toxic contaminant that accumulates in freshwater ecosystems, posing severe toxicity to non-target species such as fish and contributing to the pathogenesis of liver disease. Melatonin (Mel) is a well-known natural antioxidant that has been found to improve liver function through its potent anti-inflammatory properties. However, whether and how Mel alleviates Pb-triggered hepatotoxicity remains unclear. Mitochondria play a vital role in glucose metabolism, and glucose metabolic reprogramming is characterized by elevated glycolysis, resulting in lactate accumulation, which is a precursor for histone lactylation, an epigenetic modification. In this study, it is demonstrated that Pb triggers glucose metabolism reprogramming, resulting in lactate accumulation. Specifically, lactate links glycolysis and mitochondrial homeostasis via histone H3 lysine 18 lactylation (H3K18la), which modulates the activity of dynamin-related protein 1 (DRP1). Furthermore, DRP1 actively mediates mitochondrial fragmentation, thereby facilitating inflammatory signals derived from the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. Additionally, the results first demonstrate that Mel redirects glucose carbon utilization from glycolysis to the pentose phosphate pathway (PPP) by targeting glucose-6-phosphate dehydrogenase (G6PD). In summary, Mel targets G6PD to suppress glycolysis-driven H3K18la and DRP1 transcription, thereby maintaining mitochondrial homeostasis to alleviate hepatocytes pyroptosis dependent on cGAS-STING pathway under Pb exposure.}, archive = {J_ADVS}, author = {Zhiying Miao and Xiaofeng Ji and Lai Wei and Zhiruo Miao and Shiwen Xu}, doi = {10.1002/advs.202501041}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e01041}, shortjournal = {Adv. Sci.}, title = {Melatonin modulates glucose metabolism reprogramming via targeting G6PD to alleviate lead-induced hepatocytes pyroptosis in common carp (Cyprinus carpio l.)}, volume = {12}, year = {2025}, }
• (2025). Advanced microfluidics for single cell-based cancer research. ADVS, 12(41), e00975. (www)

  @article{ , abstract = {Cancer remains one of the leading causes of mortality worldwide, accounting for ≈10 million deaths annually. Critically, it is metastasis and not the primary tumour that causes most of these deaths. Understanding the mechanisms behind cancer dissemination and therapy resistance is thus a pressing challenge. Traditional bulk tissue analyses have failed to capture the full spectrum of intra-tumour heterogeneity and the dynamic interactions within the tumour microenvironment. Studying cancer at the single-cell level allows unravelling the roles of rare subpopulations, cell–cell interactions, and spatial dynamics that govern tumour evolution, metastasis, and immune evasion. This review explores how recent advances in microfluidic technologies are transforming ability to model and study cancer at the single-cell level. Cutting-edge platforms are highlighted, including droplet microfluidics, single cell-derived spheroids, and tumour-chips, that enable physiologically relevant 3D cancer models. By integrating immune components, biosensing, and patient-derived materials, these platforms hold promise for advancing drug screening, immunotherapy assessment, and personalised medicine. It is concluded by identifying key challenges and priorities for future work, which should focus on increasing model complexity, reproducibility, and integration of spatiotemporal multiomics to better dissect tumour heterogeneity and accelerate clinical translation.}, archive = {J_ADVS}, author = {Adriana Carneiro and Marta Aranda Palomer and Margarida Esteves and Carolina Rodrigues and José Maria Fernandes and Francisca Oliveira and Alexandra Teixeira and Carlos Honrado and Lorena Dieguez and Sara Abalde-Cela and Miguel Xavier}, doi = {10.1002/advs.202500975}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e00975}, shortjournal = {Adv. Sci.}, title = {Advanced microfluidics for single cell-based cancer research}, volume = {12}, year = {2025}, }
• (2025). Ultrathin multi-doped molybdenum oxide nanodots as a tunable selective biocatalyst. ADVS, 12(41), e00643. (www)

  @article{ , abstract = {The reactive oxygen species (ROS) serve a significant role in cancer therapy due to their oxidative capabilities to modulate cellular functions from homeostasis to apoptosis. While conventional noble metal nanoparticles exhibit superior biocatalytic efficacy in ROS induction, their indistinctive toxicity toward cells and organisms limit their potential for targeted cancer therapy. Here, ultrathin biocompatiable molybdenum oxides (MoO x ) nanodots are explored that simultaneously incorporate hydrogen (H + ) and ammonia (NH 4 + ) dopants, subsequently their electronic band structures can be modulated by both the relative contents of H + and NH 4 + dopants for efficient generation of ROS. An ultrafast and repeatable dye degredation capability in the absence of light is find in MoO x doped with low H + and high NH 4 + , in which hydroxyl radicals (·OH) is identified as the agent stimulating this ROS-driven process through scavenger analysis. More importantly, the selective biocatalytic potential of such a multi-doped MoO x is demonstrated by the comprehensive assay analysis, revealing a three-fold greater cytotoxicity toward HeLa cancer cells within 24 h compared with those of HEK293T healthy control. The finding shines a light on the targeted cancer therapies that spare healthy cells, showing the potential of multi-doped metal oxide as a biocompatiable alternatives to noble metals in selective cytotoxicity against tumor cells.}, archive = {J_ADVS}, author = {Bao Yue Zhang and Farjana Haque and Shwathy Ramesan and Sanjida Afrin and Muhammad Waqas Khan and Haibo Ding and Xin Zhou and Qijie Ma and Jiaru Zhang and Rui Ou and Md Mohiuddin and Enamul Haque and Yichao Wang and Azmira Jannat and Yumin Li and Robi S. Datta and Kate Fox and Guolang Li and Hujun Jia and Jian Zhen Ou}, doi = {10.1002/advs.202500643}, journal = {Advanced Science}, month = {11}, number = {41}, pages = {e00643}, shortjournal = {Adv. Sci.}, title = {Ultrathin multi-doped molybdenum oxide nanodots as a tunable selective biocatalyst}, volume = {12}, year = {2025}, }
• (2025). Targeting intratumoral copper inhibits tumor progression via p62-mediated EZH2 degradation and potentiates anti-PD-1 immunotherapy in oral squamous cell carcinoma. ADVS, 12(40), e17795. (www)

  @article{ , abstract = {High copper levels are required for tumor initiation and progression, termed cuproplasia. However, its role and underlying mechanisms in oral squamous cell carcinoma (OSCC) remain poorly understood. It is find that copper and its transporter SLC31A1 accumulate extensively in OSCC. Blocking copper influx through SLC31A1 siRNA or copper chelators significantly represses OSCC both in vitro and in vivo. Single-cell RNA sequencing and multiplex immunohistochemical staining revealed that copper chelators specifically decrease the stem-like tumor epithelial cell subpopulation. Further investigation shows that intratumoral copper depletion reduces histone methyltransferase EZH2 expression at the protein level, but not at the mRNA level, as determined through a screen analysis of histone-modification enzymes. Mechanistically, it is discovered that silencing SLC31A1 and treating with copper chelators increase p62-mediated EZH2 ubiquitination at the Ub-K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. Additionally, combining copper chelators with anti-PD-1 treatment effectively suppresses tumor growth, and high levels of SLC31A1 are notably associated with non-response to anti-PD-1 treatment. In conclusion, the crucial role of copper in modulating EZH2 protein stability is demonstrated, and a new approach using copper chelators and anti-PD-1 therapy for OSCC patients is provided.}, archive = {J_ADVS}, author = {Xiaohu Lin and Wanling Chen and Bo Li and Zhang Zhao and Zhonglin Yu and Xu-Yun Zhao and Xuan Zhou and Zhien Feng and Chengzhong Lin and Wei Cao}, doi = {10.1002/advs.202417795}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e17795}, shortjournal = {Adv. Sci.}, title = {Targeting intratumoral copper inhibits tumor progression via p62-mediated EZH2 degradation and potentiates anti-PD-1 immunotherapy in oral squamous cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Parasubthalamic glutamatergic neurons coordinate cardiovascular homeostasis and locomotion in mice. ADVS, 12(40), e17353. (www)

  @article{ , abstract = {Cardiovascular homeostasis and locomotion are vital for animal survival and the maintenance of essential physiological functions. The parasubthalamic nucleus (PSTN) has recently emerged as a novel interoceptive center in the central nervous system, yet its role in coordinating cardiovascular homeostasis and locomotor behavior remains poorly understood. Here, we demonstrate that PSTN Vglut2 neurons serve as a novel baroreflex center, exhibiting heightened activity during acute hypertension. Through their glutamatergic monosynaptic descending projections to the nucleus of the solitary tract (NTS), these neurons mediate parasympathetic output to regulate cardiovascular homeostasis while coordinately modulating locomotor activity. Chemogenetic activation of NTS-projecting PSTN Vglut2 neurons rapidly reduces heart rate, attenuates hypertensive responses, and accelerates blood pressure recovery. Conversely, their inhibition exacerbates blood pressure elevations, delays recovery to baseline, and impairs locomotor performance. Correlation analyses reveal a significant negative relationship between blood pressure fluctuations and locomotor metrics, such as total running distance and high-speed locomotion duration, underscoring the interdependence of cardiovascular stability and motor function. These findings position the PSTN as a critical central command hub, offering novel insights into the neural circuits governing cardiovascular homeostasis and locomotion, with potential implications for targeted neuromodulatory interventions in hypertension.}, archive = {J_ADVS}, author = {Ming-Xuan Lu and Jin-Yin Huang and Xing-Zhe Xu and Ji-Yu Sun and Dan-Ni Zou and Jia-Yao Zhang and Chen Chi and Qi Zhang and Wei-Cai Liu}, doi = {10.1002/advs.202417353}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e17353}, shortjournal = {Adv. Sci.}, title = {Parasubthalamic glutamatergic neurons coordinate cardiovascular homeostasis and locomotion in mice}, volume = {12}, year = {2025}, }
• (2025). Reprogramming of fatty acid metabolism via PPARα-orchestrated FADS2 in keratinocytes modulates skin inflammation in psoriasis. ADVS, 12(40), e17049. (www)

  @article{ , abstract = {Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyper-proliferation and immune dysregulation. Recent evidence has implicated dysregulated polyunsaturated fatty acid (PUFA) metabolism in its pathogenesis. In this study, fatty acid desaturase 2 (FADS2), the rate-limiting Δ6-desaturase in PUFA biosynthesis, is identified as a central regulator of psoriatic inflammation. FADS2 expression is consistently reduced in keratinocytes from patients with psoriasis and in mouse models. Keratinocyte-intrinsic Fads2 knockdown exacerbates imiquimod-induced psoriasis-like dermatitis, which is marked by enhanced neutrophil recruitment and NF-κB activation, whereas Fads2 overexpression exerts protective effects and alleviates skin inflammation. In vitro, FADS2 knockdown in keratinocytes enhances M5-induced pro-inflammatory cytokine production, whereas FADS2 overexpression attenuates these effects. Lipidomic analysis reveals that impaired docosahexaenoic acid (DHA) biosynthesis is a key downstream consequence of FADS2 deficiency. Mechanistically, loss of FADS2 disrupts DHA biosynthesis, thus promoting an inflammatory response accompanied by increased NF-κB phosphorylation in keratinocytes to attract neutrophils. Furthermore, PPARα is identified as an upstream transcriptional activator of FADS2, and pharmacological activation of PPARα alleviates psoriatic inflammation in a FADS2-dependent manner. Together, these findings uncover a PPARα-FADS2-DHA-NF-κB axis that links lipid metabolism to immune regulation in psoriasis, highlighting a potential therapeutic strategy for restoring cutaneous immune homeostasis.}, archive = {J_ADVS}, author = {Jiangluyi Cai and Xue Zhou and Yu Zhuang and Lian Cui and Rui Ma and Youdong Chen and Nan Yang and Qianyu Chen and Yuanyuan Wang and Peiyao Zhu and Lingling Yao and Qian Yu and Xiaomin She and Xuyang Zhou and Yuemeng Huang and Zengyang Yu and Xilin Zhang and Jiajing Lu and Yuling Shi and Chunyuan Guo}, doi = {10.1002/advs.202417049}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e17049}, shortjournal = {Adv. Sci.}, title = {Reprogramming of fatty acid metabolism via PPARα-orchestrated FADS2 in keratinocytes modulates skin inflammation in psoriasis}, volume = {12}, year = {2025}, }
• (2025). Homeostasis of gut microbiota protects against susceptibility to fungal pneumonia. ADVS, 12(40), e16455. (www)

  @article{ , abstract = {Fungal pneumonia is a serious disease with great harm and high prevalence, presenting significant challenges in diagnosis and treatment. The gut and respiratory microbiota play a critical role in protecting lung health against fungal pneumonia. Here, it is established fungal pneumonia by infection via the sinopulmonary route with Fusarium graminearum (F. graminearum) to investigate the influence of gut microbiota state on susceptibility to fungal pneumonia in BALB/c mice. This findings revealed that F. graminearum spore exposure not only impaired pulmonary clearance mechanisms but also significantly upregulated the expression of proinflammatory cytokines, including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). Moreover, spore invasion led to an increase in Staphylococcus abundance and activation of both triglyceride and galactose metabolic pathways. Antibiotic treatment disrupted the gut and respiratory microbiota, facilitating F. graminearum lung colonization, which is evidenced by elevated inflammatory markers in alveolar fluid and dysregulated lung metabolism. It is demonstrated that the gut microbiota influences susceptibility to fungal pneumonia by acting as an intermediary in the gut-lung axis through the bloodstream, thereby modulating lung metabolism and inflammatory responses. These findings open avenues for novel therapeutic strategies, such as gut microbiota modulation, for the prevention and treatment of fungal pneumonia.}, archive = {J_ADVS}, author = {Jian Ji and Yongli Ye and Jiadi Sun and Lina Sheng and Jinyou Li and Jin Yang and Bing Wu and Yuting Wang and Xingxing Gao and Liang Luo and Jianfeng Ping and Yinzhi Zhang and Xiulan Sun}, doi = {10.1002/advs.202416455}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e16455}, shortjournal = {Adv. Sci.}, title = {Homeostasis of gut microbiota protects against susceptibility to fungal pneumonia}, volume = {12}, year = {2025}, }
• (2025). D-glucuronyl c5-epimerase binds to EGFR to suppress kidney fibrosis. ADVS, 12(40), e16216. (www)

  @article{ , abstract = {Renal tubular cells actively participate in fibrosis, leading to end-stage renal failure. However, the key molecules involved in fibrogenesis remain unclear. Glucuronyl C5-epimerase ( Hsepi , gene name, Glce ) is a key enzyme that catalyzes the biosynthesis of heparan sulfate (HS) chains attached to HS proteoglycans that are ubiquitously located on the cell membrane. Homozygous Glce -/- mice may exhibit embryonic lethality and multi-organ defects. However, the role of Glce in kidney fibrosis remains unclear. This study investigated the contribution of Glce to kidney development and its role in renal fibrosis pathogenesis. Here, it shows that Glce expression is significantly attenuated in the kidneys of patients with renal fibrosis and in animal models. Renal tubular-specific Glce deletion in mice exacerbated kidney fibrosis, while AAV-mediated Glce overexpression in unilateral ureteral obstruction-treated mice ameliorated kidney fibrosis via the TGF-β/Smad2/3 signaling pathway. Mechanistic studies indicate that Glce protein may bind to epidermal growth factor receptor (EGFR) to inactivate EGFR/ERK signaling and further impede TGF-β/Smad signaling pathway and renal fibrosis in Glce -/- and wild-type mice. Notably, the anti-fibrotic function is independent of Glce enzymatic activation. These findings reveal a novel function of Glce , which plays a key role in kidney fibrosis.}, archive = {J_ADVS}, author = {Xiaoqi Jing and Jun Wu and Jingru Ning and Xiaoyu Ding and Zhenyun Du and Xiaojiang Wang and Lulin Huang and Ran Wang and Changlin Mei and Kan Ding}, doi = {10.1002/advs.202416216}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e16216}, shortjournal = {Adv. Sci.}, title = {D-glucuronyl c5-epimerase binds to EGFR to suppress kidney fibrosis}, volume = {12}, year = {2025}, }
• (2025). Nicotine reprograms aging-related metabolism and protects against motor decline in mice. ADVS, 12(40), e15311. (www)

  @article{ , abstract = {The effects of nicotine on aging-related motor and cognitive decline remain controversial due to limited empirical evidence. Here, mice are permitted to orally consume nicotine over a 22-month period and observed attenuated motor decline without pathological alterations in major metabolism-related peripheral organs or immune system dysfunction. Multi-organ metabolomic profiling and network analysis of aged mice (24 months old) identified nicotine-responsive pathways related to glycolipid metabolism and energy homeostasis. Dynamic gut microbiota profiling via series expression miner-based longitudinal analysis reveals that nicotine consumption preserved microbiota composition and altered microbial-derived metabolites associated with the sphingolipid pathway, known to regulate age-related muscle dysfunction and sarcopenia. Assays in aged mice and C2C12 cells confirmed that nicotine regulates sphingolipid turnover, particularly via sphingomyelin synthases and neutral sphingomyelinases, to enhance nicotinamide adenine dinucleotide availability and energy metabolism. These metabolic adaptations correlated with reduced ceramide accumulation and improved motor function. Behavior-Metabolome Age (BMAge) score confirmed a biologically younger phenotype in the nicotine-treated mice. Together, these findings suggest that life-long oral nicotine consumption reprograms aging-associated metabolism through regulation of systemic sphingolipid homeostasis, conferring resilience against age-related motor decline.}, archive = {J_ADVS}, author = {Shuhui Jia and Xiaoyuan Jing and Ruoxi Wang and Mengke Su and Pei Wang and Yingxin Feng and Xiaohu Ren and Longfang Tu and Ping Wei and Zhen Lu and Yicong Jia and Feng Hong and Zhizhun Mo and Jiemeng Zou and Kang Huang and Caiyun Yan and Qianhui Zou and Liang Wang and Guoping Zhong and Zhi Zeng and Qiuliyang Yu and Wen Su and Xifei Yang and Fan Pan and Jianzhi Wang and Liping Wang and Lijun Kang and Paul J. Kenny and Zuxin Chen and Xin-an Liu}, doi = {10.1002/advs.202415311}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e15311}, shortjournal = {Adv. Sci.}, title = {Nicotine reprograms aging-related metabolism and protects against motor decline in mice}, volume = {12}, year = {2025}, }
• (2025). Correction to “Dual-action psoriasis therapy: Antiproliferative and immunomodulatory effects via self-locking microneedles”. ADVS, 12(40), e15046. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202515046}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e15046}, shortjournal = {Adv. Sci.}, title = {Correction to “Dual-action psoriasis therapy: Antiproliferative and immunomodulatory effects via self-locking microneedles”}, volume = {12}, year = {2025}, }
• (2025). Tumor microenvironment-responsive nanomedicines for potentiating cancer immunotherapy. ADVS, 12(40), e13567. (www)

  @article{ , abstract = {Immunotherapy has emerged as a transformative paradigm in oncology, yet its clinical efficacy remains constrained by the immunosuppressive tumor microenvironment and inadequate spatiotemporal control of existing modalities, resulting in suboptimal patient response rates and frequent immune-related adverse events. Stimuli-responsive biomaterials, capable of precise modulation over the delivery kinetics of immunotherapeutic agents, are validated as powerful strategies for achieving targeted immunomodulation. This review systematically delineates innovative design frameworks for tumor microenvironment (TME)-responsive nanomaterials leveraging dynamic TME features. Through detailed dissection of cancer-immunity cycle barriers, including spanning impaired antigen presentation, compromised T cell priming/activation, and defective effector function, breakthrough advances in next-generation delivery platforms are highlighted that reignite antitumor immunity at a critical juncture. Furthermore, preclinical validation and clinical translation challenges of TME-responsive nanomaterials are evaluated. Building upon current immunotherapy trends, this review also identifies critical translational determinants, with the aim of bridging the bench-to-bedside gap in precision cancer immunotherapy.}, archive = {J_ADVS}, author = {Qianqian Huang and Fan Tong and Jiantao Chen and Muzaffar Kayumov and Yue Lv and Yajun Shi and Bengui Ye and Huile Gao}, doi = {10.1002/advs.202513567}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e13567}, shortjournal = {Adv. Sci.}, title = {Tumor microenvironment-responsive nanomedicines for potentiating cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Gal3-CaN-smurf1 complex sequestrates FLCN-FNIPs to facilitate TFEB activation in response to endomembrane damage. ADVS, 12(40), e13241. (www)

  @article{ , abstract = {Smurf1 mediates lysosomal biogenesis upon endomembrane damage by interacting with lysosomal injury sensor Gal3 and phosphatase CaN to form Gal3-CaN-Smurf1 complex, which is critical for TFEB dephosphorylation. However, whether Smurf1 plays a role in the inhibition of mTOR-mediated TFEB phosphorylation is still unclear. TFEB phosphorylation by mTORC1 is strictly dependent on RagC/D GTPase activating protein FLCN. Here, we found that Smurf1 promotes the dissociation of RagC from TFEB upon lysosomal damage, selectively impairing TFEB phosphorylation. These findings suggest that the lysosomal damage-induced Gal3-CaN-Smurf1 complex sequesters FLCN-FNIPs to facilitate TFEB activation. This disruption of FLCN GAP function toward RagC/D impairs TFEB's lysosomal localization and phosphorylation. Notably, FLCN K462R and/or FNIP2 K466R mutations reduce their binding affinity with the Gal3-CaN-Smurf1 complex, suggesting Smurf1-mediated poly-ubiquitylation of FLCN K462 and FNIP2 K466 plays a role for pentamer formation. Indeed, sequestration of FLCN-FNIPs stabilizes the Gal3-CaN-Smurf1 complex, wherein Smurf1 directly binds and ubiquitinates TFEB. This facilitates TFEB's dephosphorylation and activation. These findings indicate that Gal3-CaN-Smurf1 complex interconnects with the FLCN-FNIPs to orchestrate TFEB localization and activity in response to lysosomal damage stress. Understanding Smurf1's regulation in the mTOR-TFEB axis, which balances tumor growth and stress-induced cell homeostasis, may provide novel therapeutic targets for tumor progression and drug resistance.}, archive = {J_ADVS}, author = {Qin Xia and Ziwan Liu and Gaoqing Feng and Wanting Xu and HuaHua Wang and Haihang Su and Jiaqian Li and Dan Liu and Jun Qu and Tonghui Yu and Lei Dong}, doi = {10.1002/advs.202413241}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e13241}, shortjournal = {Adv. Sci.}, title = {Gal3-CaN-smurf1 complex sequestrates FLCN-FNIPs to facilitate TFEB activation in response to endomembrane damage}, volume = {12}, year = {2025}, }
• (2025). Electrochemical approach to organonitrogen compounds via C–N coupling. ADVS, 12(40), e13012. (www)

  @article{ , abstract = {The C–N bond is a cornerstone in the structures of many essential compounds, including amino acids, pharmaceuticals, agrochemicals, and natural products. Traditional methods for C–N coupling often rely on noble-metal-based catalysts and harsh reaction conditions, which limit their sustainability. In contrast, electrocatalytic C–N coupling has emerged as a more environmentally friendly alternative, offering mild reaction conditions, high selectivity, and compatibility with renewable energy integration. This review provides an overview of recent advances in the field of organonitrogen electrosynthesis, focusing on various nitrogen and carbon sources, their activation mechanisms, and the impact of key parameters such as applied potentials, pH values, and electrolyte composition. Various catalyst design strategies and electrochemical characterization techniques are also discussed. In addition, it examines different electrochemical cell configurations. Furthermore, this review highlights the electrosynthesis of key organonitrogen products such as urea, oximes, amino acids, amides, and amines, while discussing the current challenges and outlining future opportunities for advancing sustainable C–N bond formation.}, archive = {J_ADVS}, author = {Haifei Liu and Wenbo Wei and Qi-Long Zhu}, doi = {10.1002/advs.202513012}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e13012}, shortjournal = {Adv. Sci.}, title = {Electrochemical approach to organonitrogen compounds via C–N coupling}, volume = {12}, year = {2025}, }
• (2025). Decoding buried interfaces in perovskite solar cells: Core issues, strategic engineering, and prospects for high-efficiency stable devices. ADVS, 12(40), e12523. (www)

  @article{ , abstract = {Perovskite solar cells (PSCs) have emerged as a frontrunner in photovoltaic technologies, owing to their high performance and low-cost scalability. However, their efficiency remains substantially below the theoretical Shockley-Queisser limit (>30%), and their long-term stability is severely compromised; both are predominantly driven by interface-related issues. Compared to the top interface, buried interfaces are equally important, if not more important, effects on perovskite film quality and device performance. This review comprehensively analyzes challenges at buried interfaces, including defects, terminations, strain, carrier dynamics, and chemical reactions, with special focus on self-assembled monolayer (SAM)-based devices and textured interfaces in perovskite/silicon tandem solar cells. Targeted modification strategies such as defect passivation, strain control, carrier transport modulation, and inhibition of adverse reactions are proposed to mitigate these issues. Finally, research prospects for optimizing buried interfaces are outlined, including advanced in situ characterizations, novel charge transport materials, and innovative interface engineering to enhance PSC performance and stability.}, archive = {J_ADVS}, author = {Peng Mao and Weihui Bi and Jun Lv and Zongbao Zhang and Bing Wang and Yufei Zhong}, doi = {10.1002/advs.202512523}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e12523}, shortjournal = {Adv. Sci.}, title = {Decoding buried interfaces in perovskite solar cells: Core issues, strategic engineering, and prospects for high-efficiency stable devices}, volume = {12}, year = {2025}, }
• (2025). Recent advances on transition metal sulfides for key components of Lithium–Sulfur batteries. ADVS, 12(40), e12191. (www)

  @article{ , abstract = {Lithium–sulfur batteries (LSBs), renowned for their cost-effectiveness and high energy density, stand out as highly promising energy storage solutions with substantial application potential. Nevertheless, the shuttle effect—caused by the migration of polysulfides between cathode and anode—severely hampers their practical implementation. Extensive research has demonstrated that transition metal sulfide (TMS) catalysts can effectively mitigate this shuttle phenomenon. In LSBs, the cathode, anode, and separator represent pivotal components, and their properties play a decisive role in determining the electrochemical performance. As such, current mainstream modification strategies mainly target these three key areas. Therefore, this review focuses on the latest advances in the application of TMSs in key components of LSBs. It systematically analyzes the core issues currently faced, deeply elaborates on the roles and shortcomings of different TMS modification methods and their application approaches in various LSB components, and discusses the underlying mechanisms. Aiming at the above problems, this paper proposes potential solutions and research directions, hoping to provide references for researchers in related fields.}, archive = {J_ADVS}, author = {Jingxuan Chen and Tingting Sun and Junliang Liu and Hao Yu and Qisheng Zang and Tong Yuan and Fuqin Zhang}, doi = {10.1002/advs.202512191}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e12191}, shortjournal = {Adv. Sci.}, title = {Recent advances on transition metal sulfides for key components of Lithium–Sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). Shifu-inspired fungal paper yarns. ADVS, 12(40), e11975. (www)

  @article{ , abstract = {Fungal biorefinery is a popular method for producing advanced fabrics but is currently limited to leather alternatives and similar by the sheet-based nature of most fungal materials. Biopolymers in the fungal cell wall, such as chitin and chitosan, are only soluble in harsh chemicals, making established extrusion-based yarn production systems expensive and hazardous. The Japanese art of Shifu is used to produce fungal chitin-β-glucan yarns of varying linear density from engineered fungal sheets, enabling the production of yarns. Yarn mechanical strength is influenced by sheet precursor grammage and can be tuned using various chemical modifications such as glycerol-based plasticization. Yarns hybridized with nanocellulose exhibited low strength, stiffness, and ductility, due to weak interfacing with fungal sheets. With mechanical properties outperforming commercial cellulose paper yarns and on par with cotton and viscose yarns, fungal yarns produced from engineered sheets of fungal biomass using Shifu techniques represent a viable yarn candidate for a broad range of applications, yet unachieved using fungi, such as textiles, upholstery, and carpets for the fashion and décor sectors.}, archive = {J_ADVS}, author = {Anne Zhao and Mitchell P. Jones and Kathrin Weiland and Alexander Bismarck}, doi = {10.1002/advs.202511975}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11975}, shortjournal = {Adv. Sci.}, title = {Shifu-inspired fungal paper yarns}, volume = {12}, year = {2025}, }
• (2025). Brain-wide spatiotemporally distinct traveling waves drive anxiety-like behaviors in mice. ADVS, 12(40), e11867. (www)

  @article{ , abstract = {Cortical traveling waves coordinate communication among distributed neural ensembles to modulate brain function and dysfunction through distinct spatiotemporal propagation patterns. However, the brain-wide propagation dynamics of traveling waves from different origins and their roles in regulating behavior remain unclear. Using optogenetics alongside whole-brain fMRI in mice, it is demonstrated that optogenetic activation of the medial prefrontal cortex and primary somatosensory area induces cortical spreading depression (CSD)-like traveling waves. These waves propagate beyond the ipsilateral cortex to the contralateral cortex and midbrain, reaching subcortical structures along cortico-amygdala-striatal pathways, ultimately terminating in the striatum ≈4 min after induction. The propagation directions in the cortex, speed, duration, and region involvement vary with wave origins. Furthermore, these CSD-like traveling waves induce anxiety-like behaviors and increase dendritic spine density. The findings elucidate the complete process from induction to termination of traveling waves across the whole brain and reveal their previously undiscovered role in driving anxiety.}, archive = {J_ADVS}, author = {Jiaming Liu and Jia-Wen Mo and Xunda Wang and Yinuo Ma and Shile Tian and Qi Wang and Peng-Li Kong and Ziqi An and Li Ding and Jing Ren and Cheng-Lin Lu and Chuanjun Tong and Ed X. Wu and Qiu-gen Hu and Xiong Cao and Yanqiu Feng}, doi = {10.1002/advs.202411867}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11867}, shortjournal = {Adv. Sci.}, title = {Brain-wide spatiotemporally distinct traveling waves drive anxiety-like behaviors in mice}, volume = {12}, year = {2025}, }
• (2025). Lactate dehydrogenase c4 accelerates triple-negative breast cancer progression by promoting acetyl-CoA acyltransferase 2 lactylation to increase free fatty acid accumulation. ADVS, 12(40), e11849. (www)

  @article{ , abstract = {Lactate-induced protein lysine (K) lactylation is inherently connected to cellular metabolism and is implicated in oncogenesis. As a crucial glycolytic enzyme in lactate metabolism, lactate dehydrogenase C4 (LDHC4) has undefined yet potentially significant biological functions and mechanistic roles in triple-negative breast cancer (TNBC) that warrant further investigation. This study aims to determine whether and how LDHC4 affects TNBC progression by regulating protein lactylation. LDHC4 expression in human TNBC tissues and adjacent nontumor tissues is analyzed through immunoblotting and immunohistochemistry (IHC). Functional experiments verified the biological features of LDHC4 in human TNBC cells both in vitro and in vivo (subcutaneous, orthotopic, and pulmonary metastatic mouse models). 4D label-free lactylproteome expression analysis (4D-LFQP-LA), immunoblotting, and immunoprecipitation are utilized to confirm lactylation at specific lysine sites in acetyl-CoA acyltransferase 2 (ACAA2) following LDHC4 induction. Targeted lipidomic analysis is performed to characterize ACAA2-induced metabolite alterations. Immunoblotting, immunofluorescence, and transmission electron microscopy are performed to investigate the mechanisms underlying LDHC4-induced ACAA2 lactylation and tumor progression in TNBC. LDHC4 expression is upregulated in TNBC, and LDHC4 is an independent predictive factor for prognosis. Both in vitro and in vivo experiments demonstrated that LDHC4 promotes TNBC progression. Subsequent mechanistic investigation revealed that LDHC4 enhances the lactylation of ACAA2 at K214, resulting in increased ACAA2 catalytic activity. This increase in ACAA2 activity accelerates fatty acid (FA) metabolism, promotes TNBC progression both in vitro and in vivo, and leads to increased free fatty acid (FFA) generation and accumulation. The increase in FFAs in turn induces autophagy and promotes cell cycle activity in TNBC cells, thereby promoting TNBC progression. The findings reveal a novel pathway through which LDHC4 induces ACAA2 lactylation to regulate FA metabolism in TNBC cells, thus promoting TNBC progression, highlighting the critical role of LDHC4 in TNBC progression.}, archive = {J_ADVS}, author = {Zhaolei Cui and Chaoqiang Zheng and Yingying Lin and Zhenzhou Xiao and Yanhong Li and Wei Peng and Shijie He and Anyang Li and Xiufeng Wu and Yan Chen and Yang Sun}, doi = {10.1002/advs.202511849}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11849}, shortjournal = {Adv. Sci.}, title = {Lactate dehydrogenase c4 accelerates triple-negative breast cancer progression by promoting acetyl-CoA acyltransferase 2 lactylation to increase free fatty acid accumulation}, volume = {12}, year = {2025}, }
• (2025). Tough cellulose hydrogel electrolyte with low solvation for highly reversible and flexible aqueous zinc-ion battery. ADVS, 12(40), e11759. (www)

  @article{ , abstract = {Recent advancements in hydrogel electrolytes for aqueous zinc-ion batteries (AZIBs) have drawn considerable interest due to their soft nature, offering potential to overcome challenges including reversibility and flexibility. As the most abundant natural polymer, cellulose is ideal for AZIB hydrogel electrolytes due to rich hydroxyls with stable hydrogen-bonded networks for water retention. However, conventional cellulose hydrogels suffer from low Zn 2+ conductivity and insufficient mechanical robustness, usually requiring additional polymers to meet practical demands. This work reports a chemically neutral dissolution system combined with Keggin-type polyoxometalate as a bifunctional crosslinker and electrolyte modulator. This approach results in ultra-low solvation of Zn 2+ in cellulose hydrogel, contributing to a wide 2.48 V electrochemical stability window. The high-desolvation hydrogel exhibits balanced Zn 2+ reaction stability and transport kinetics, effectively suppressing dendrite growth and parasitic reactions. The Zn electrode can be stably strapped/plated with this hydrogel for thousands of cycles with minimal Coulomb efficiency change. The hydrogel also shows excellent flexibility, with toughness of 1.5 MJ m −3 and elongation at break of 80%. Pouch cells assembled with this hydrogel demonstrate high mechanical flexibility and stability under deformations. This pioneering cellulose dissolution and crosslinking chemistry paves the way for practical application of flexible, durable AZIBs.}, archive = {J_ADVS}, author = {Fan Chen and Xuan Li and Shi-Peng Chen and Yilin Zhang and Hua-Dong Huang and Hongli Yang and Shengyang Zhou and Zhong-Ming Li}, doi = {10.1002/advs.202511759}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11759}, shortjournal = {Adv. Sci.}, title = {Tough cellulose hydrogel electrolyte with low solvation for highly reversible and flexible aqueous zinc-ion battery}, volume = {12}, year = {2025}, }
• (2025). Inspired by reinforced-concrete structures: High-strength, stable, sustainable reed-based plastics. ADVS, 12(40), e11564. (www)

  @article{ , abstract = {Green and sustainable alternatives to petroleum-based plastics can reduce environmental pollution and alleviate the resource crisis. Reed straw (Rs) is a rapidly growing, eco-friendly, low-cost, and natural fiber with great potential as a sustainable resource. However, the development of high-performance plastic substitutes from Rs is challenging owing to its weak interfacial bonding. Herein, inspired by the structure of reinforced concrete, a top-down strategy is adopted using a simple and rapid physical-filling and directional-assembly method in which the adhesive is evenly filled and adhered to the regular and continuous reed fiber skeleton. A reed-based plastic with high strength, stability, fire resistance, and nontoxicity is developed using this approach via densification and rapid curing. The flexural strength, flexural modulus, and tensile strength of the material are 116 ± 8.05 MPa, 13.54 ± 0.67 GPa, and 81 ± 9.85 MPa, respectively. Moreover, the material demonstrated excellent dimensional stability during baking at 120 °C baking and 24 h of water immersion, and achieved a V-0 rating in the UL-94 test without producing toxic gases during pyrolysis. Benefiting from these properties, the developed reed-based plastic demonstrates potential as a sustainable alternative to conventional petroleum-derived plastics, with promising applications in home decor and structural construction.}, archive = {J_ADVS}, author = {Yuhui Huang and Handong Li and Meng Li and Kui Li and Yawen Zhang and Zhen Zhang and Yingfeng Zuo and Yiqiang Wu}, doi = {10.1002/advs.202511564}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11564}, shortjournal = {Adv. Sci.}, title = {Inspired by reinforced-concrete structures: High-strength, stable, sustainable reed-based plastics}, volume = {12}, year = {2025}, }
• (2025). Artificial nervous systems. ADVS, 12(40), e11478. (www)

  @article{ , abstract = {Electronic devices and systems that can emulate the complex cognitive abilities of nervous systems have been an important research topic in recent years. Artificial nervous systems with multimodal perception, neural signal processing, and reflex-driven functionalities have been established by integrating multimodal sensors, neuromorphic synaptic devices, and effector units. The important value of artificial nervous systems is mainly embodied in bioinspired information processing, transmission, and environmental adaptation aspects. However, since this field is still in its early stages, more exploration is needed to realize artificial nervous systems with autonomous adaptability, intelligent feedback, and bio-interfacing applications. This review provides a comprehensive overview of recent advancements, spanning from the fundamental device structure and mechanism of synaptic devices to bio-inspired artificial nervous systems. Finally, a brief perspective of this research field is provided.}, archive = {J_ADVS}, author = {Lu Yang and Qingwen Cheng and Yue Li and Ning Wu and Zhipeng Xu and Wentao Xu}, doi = {10.1002/advs.202511478}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11478}, shortjournal = {Adv. Sci.}, title = {Artificial nervous systems}, volume = {12}, year = {2025}, }
• (2025). Beyond half-cell success: Cathode-electrolyte reactivity driving magnesium battery full-cell degradation at elevated temperature. ADVS, 12(40), e11416. (www)

  @article{ , abstract = {Rechargeable magnesium battery (RMB) is gaining attention as a promising alternative to lithium-ion batteries, offering advantages such as low cost and high theoretical capacity of magnesium metal anodes. Yet, realizing stable, high-voltage RMB full cells remains a considerable challenge. In this study, a full-cell configuration is explored combining a vanadium oxide (VO 2 ) cathode with a weakly coordinating anion-based electrolyte. While encouraging performance is observed in half-cell setups, translating it into full-cell operation proves complex, particularly at elevated temperatures. At 60 °C, the initial discharge capacity of 77 mAh g −1 decreases notably to 28 mAh g −1 in the second cycle, whereas performance at 30 °C remains more stable ≈25 mAh g −1 . Three-electrode measurement suggests increasing overpotentials at the Mg anode as a key factor in the capacity degradation. Further analysis points to issues such as uneven Mg plating/stripping, surface pitting, and minor vanadium dissolution, contributing to impedance growth and cross-over effects. These are linked to cathode–electrolyte side reactions, particularly under high-voltage. Overall, the results emphasize the importance of developing stable interphases to enhance the long-term performance of RMB full cells, especially at elevated temperatures.}, archive = {J_ADVS}, author = {Dedy Setiawan and Omar Falyouna and Toshihiko Mandai}, doi = {10.1002/advs.202511416}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11416}, shortjournal = {Adv. Sci.}, title = {Beyond half-cell success: Cathode-electrolyte reactivity driving magnesium battery full-cell degradation at elevated temperature}, volume = {12}, year = {2025}, }
• (2025). Dual-ligand strategy in rh-catalyzed sequential hydrofunctionalization of valylene. ADVS, 12(40), e11331. (www)

  @article{ , abstract = {Controlling regio- and chemo-selectivity in transition-metal-catalyzed reactions involving coupling reagents with multiple reactive sites remains a significant challenge. In this study, a dual-ligand strategy is introduced to orthogonally regulate both nucleophilic and electrophilic sites in the rhodium-catalyzed sequential hydrofunctionalization of valylene. Leveraging the synergistic effects of bidentate and monodentate phosphine ligands, cyclic prenylation of 4-hydroxycoumarins is achieved with outstanding regio- and chemo-selectivity under basic conditions. Conversely, structurally reversed prenylation is selectively obtained using a dppb (1,4-bis(diphenylphosphino)butane)/DME (1,2-dimethoxyethane) ligand combination under acidic conditions. This efficient and versatile protocol is also applicable to pyrazol-5-one substrates, yielding high-value dihydropyrano[2,3-c]pyrazole analogs. Mechanistic studies suggest that the cyclic prenylation proceeds via C3- or O-propargylation, followed by Rh- or acid-promoted intermolecular annulation. It is hoped that this strategy will provide valuable insights for addressing selectivity challenges in transition-metal catalysis and inspire further developments in this field.}, archive = {J_ADVS}, author = {Yong-Kang Mei and Su-Yang Xu and Zhi-Hui Wang and Ding-Wei Ji and Qing-An Chen}, doi = {10.1002/advs.202511331}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11331}, shortjournal = {Adv. Sci.}, title = {Dual-ligand strategy in rh-catalyzed sequential hydrofunctionalization of valylene}, volume = {12}, year = {2025}, }
• (2025). Branched-chain α keto-acid dehydrogenase kinase-mediated AKT phosphorylation promotes RCC tumorigenesis and drug resistance. ADVS, 12(40), e11081. (www)

  @article{ , abstract = {Advanced renal cell carcinoma (RCC) primarily relies on targeted and immune-based therapies, yet these treatments often face limitations due to inefficacy and drug resistance. Branched-chain α-keto-acid dehydrogenase kinase (BCKDK) has been implicated in promoting RCC metastasis, but its specific substrates and the mechanisms underlying its regulation of RCC progression remain poorly understood. This study uncovers a novel mechanism whereby BCKDK-mediated AKT phosphorylation drives RCC tumorigenesis and drug resistance. Elevated BCKDK expression correlates with poor prognosis in RCC clinical samples. BCKDK deficiency inhibits RCC cell proliferation and tumorigenesis both in vitro and in vivo. Mechanistic investigations reveal that BCKDK directly binds to and regulates the phosphorylation of AKT. BCKDK-mediated phosphorylation of AKT decreases ubiquitin-mediated AKT protein degradation, and promotes tumorigenesis via activation of the AKT/mTOR signaling pathway. RNA sequencing identifies BCKDK's involvement in the drug metabolism network and apoptotic signaling pathways. The BCKDK/AKT/ABCB1 axis mediates doxorubicin resistance. Targeting BCKDK/AKT inhibits the growth of RCC patient-derived organoids (PDOs), enhances doxorubicin-induced apoptosis in RCC cells, and suppresses tumor growth in vivo. These findings identify a previously unrecognized phosphorylation substrate of BCKDK and highlight the critical role of the BCKDK/AKT signaling axis in RCC progression, offering a promising target for therapeutic intervention.}, archive = {J_ADVS}, author = {Qin Tian and Jinxiang Wang and Qiji Li and Yangruiyu Liu and Yanping Chen and Jiacheng Feng and Zi-Ning Lei and Harsh Patel and Chao-Yun Cai and Yuzhi Xu and Chuntao Quan and Lingyan Fei and Zexiu Xiao and Shuo Fang and Tianxin Lin and Zhe-Sheng Chen and Yuchen Liu and Leli Zeng and Yihang Pan}, doi = {10.1002/advs.202411081}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11081}, shortjournal = {Adv. Sci.}, title = {Branched-chain α keto-acid dehydrogenase kinase-mediated AKT phosphorylation promotes RCC tumorigenesis and drug resistance}, volume = {12}, year = {2025}, }
• (2025). D-electron asymmetry-driven CN coupling on heteronuclear dual-atom catalysts for sustainable urea electrosynthesis. ADVS, 12(40), e11001. (www)

  @article{ , abstract = {The transition toward carbon-neutral chemical manufacturing calls for innovative strategies to produce nitrogen-based compounds with minimal environmental impact. Urea, a key nitrogen-rich chemical, is currently synthesized via the energy-intensive Bosch-Meiser process, which relies heavily on fossil fuel-derived ammonia. As a sustainable alternative, electrochemical urea synthesis (ECUS) enables the direct coupling of nitrogenous and carbonaceous precursors under ambient conditions, yet remains hampered by sluggish kinetics and poor selectivity—particularly in the critical C─N bond formation step. Here, density functional theory (DFT) calculations is integrated with data-driven machine learning to systematically explore the activity landscape of nitrogen-doped graphene-supported dual-metal-atom catalysts (M′M@NC) for C─N coupling. A comprehensive reaction network is evaluated across 45 M′M@NC configurations, revealing three heteronuclear catalysts—VNi@NC, CoNi@NC and CoCu@NC—with consistently favorable thermodynamic and kinetic performance. Electronic structure analysis indicates that heteronuclear coordination promotes *CO activation and optimizes *NH x adsorption, facilitating C─N coupling. Leveraging symbolic regression via the sure independence screening and sparsifying operator (SISSO) algorithm, interpretable descriptors linking C─N coupling energy to atomic-level electronic properties is established, highlighting the critical role of d-electron asymmetry. This results uncover fundamental design principles for dual-atom catalysts and provide a predictive framework for guiding the development of next-generation electrocatalysts for sustainable urea synthesis.}, archive = {J_ADVS}, author = {Zaifu Jiang and Jingjing Wang and Dingmei Zhang and Panlong Kong and Xiaotao Zhang}, doi = {10.1002/advs.202511001}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e11001}, shortjournal = {Adv. Sci.}, title = {D-electron asymmetry-driven CN coupling on heteronuclear dual-atom catalysts for sustainable urea electrosynthesis}, volume = {12}, year = {2025}, }
• (2025). 3D covalent organic network membranes with regionally ordered nanochannels for efficient molecular sieving. ADVS, 12(40), e10911. (www)

  @article{ , abstract = {Polymeric composite membranes hold significant promise for molecular sieving in organic solvents, yet struggle with the precise fractionation of small molecules, a critical need in the chemical and pharmaceutical industries. Here an innovative covalent organic network (CON) membrane featuring 3D interpenetrated ultra-microporous channels for effective fractionation of small-molecule solutes is presented. Rational utilization of unique tetrahedral amine (TAM) as aqueous-phase building blocks to crosslink with acyl chlorides yields CON polyamide thin films with finely tuned ordered porosity. Importantly, three-node acyl chloride (TMC) with high reactivity facilitates sharpening the membrane pore size distribution due to the partially ordered and elevated crosslinked structure. Molecular dynamics simulations reveal that these TAM-TMC membranes possess a high fractional free volume, contributing to superior permeability-selectivity performance. Further post-activation with polar solvents effectively modulates the inherent pore polarity and width, resulting in an exceptional methanol permeability of 7.5 L m −2 h −1 bar −1 and a molecular weight cut-off of 248 Da. This ultrafine 3D hierarchical pore architecture enables excellent fractionation of dye mixtures with similar molecular weights and efficient antibiotic concentration. This work rationalizes the design of chemically stable covalent organic network membranes with 3D partially ordered sub-microporosity, extending their application to precision molecular separations.}, archive = {J_ADVS}, author = {Lei Ge and Gaojing Du and Hengjie Song and Jiaqi Li and Jingwei Hou and Yatao Zhang and Junyong Zhu}, doi = {10.1002/advs.202510911}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10911}, shortjournal = {Adv. Sci.}, title = {3D covalent organic network membranes with regionally ordered nanochannels for efficient molecular sieving}, volume = {12}, year = {2025}, }
• (2025). MXene-integrated printed piezoresistive flexible sensors: A breakthrough in real-time monitoring for medical and smart applications. ADVS, 12(40), e10894. (www)

  @article{ , abstract = {As an emerging 2D transition metal carbide material with metal-like conductivity, MXene exhibits significant potential in the development of piezoresistive sensors. Nevertheless, achieving favorable combined properties in MXene-based pressure sensors remains challenging. This research explores a method for the assisted deposition of Ag nanoparticles between the layers of waffle-structured MXene by template-directed growth strategy, preparing the chocolate-inlaid Ag@waffle-structured MXene (WSM-A8). With DFT calculations and finite element simulations, the theoretical analysis for the transition of energy bands and the increase of charge density is conducted for the WSM-A8. Meanwhile, the conducting pathways established in WSM-A8 are systematically simulated, verifying the construction of the oriented field-modulation piezoresistive structure proposed in this study. The pressure sensor prepared with WSM-A8 presents the highest Δ I / I 0 response intensity (507 in 210 kPa) among the reported MXene-based piezoresistive sensors with a satisfactory sensitivity (45/30 ms for response/recovery time), which also possesses outstanding structural stability (less than 4% attenuation of the response value after 500 bending cycles) and superior oxidation resistance. Utilizing the convolutional neural network and machine learning, the recognition accuracy of the integrated device is effectively improved. This study provides a feasible approach for realizing real-time pressure monitoring, demonstrating great potential in medical diagnosis, intelligent actuators, and human–computer interactions.}, archive = {J_ADVS}, author = {Hao-wen Zhang and Xiang Xu and Di-wen Jiang and Jie Lu and Yang-sheng Wang and Zhe-sheng Feng and Yan Wang}, doi = {10.1002/advs.202510894}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10894}, shortjournal = {Adv. Sci.}, title = {MXene-integrated printed piezoresistive flexible sensors: A breakthrough in real-time monitoring for medical and smart applications}, volume = {12}, year = {2025}, }
• (2025). Clay-mineral-coated separators for lithium-ion batteries: Exploring the relationships between clay mineral morphology and separator performance. ADVS, 12(40), e10779. (www)

  @article{ , abstract = {Polyolefin separators comprising polyethylene and polypropylene have long been used in commercial Li-ion batteries because of their electrochemical stability, robust mechanical properties, uniform pore structure, and cost-effectiveness. However, conventional separators have limitations in withstanding harsh environmental conditions, such as elevated temperatures, owing to their poor mechanical durability. Moreover, with the development of advanced Li rechargeable batteries, these separators are required to overcome new challenges such as preventing the migration of polysulfide intermediates in Li–S batteries and inhibiting the formation of Li dendrites in Li metal batteries. Natural clay minerals have emerged as a viable solution to these issues owing to their porous structure, high mechanical strength, and abundant polysulfide-capturing Lewis acid sites. However, the manner in which the structural characteristics of minerals influence the separator performance has not been extensively assessed, thereby impeding the development of separators for future high-performance Li batteries. This review comprehensively outlines various clay minerals and their effects on the parameters and performance metrics of battery separators. Based on this review, a design guide is proposed for mineral-based separators that could potentially be integrated into next-generation Li batteries with high energy density and long-term stability.}, archive = {J_ADVS}, author = {Inseo Ko and Seoyoung Ha and Weon Ho Shin and Jongyoung Choi and Sung Cik Mun and Yong-Seok Choi and Jong Ho Won}, doi = {10.1002/advs.202510779}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10779}, shortjournal = {Adv. Sci.}, title = {Clay-mineral-coated separators for lithium-ion batteries: Exploring the relationships between clay mineral morphology and separator performance}, volume = {12}, year = {2025}, }
• (2025). Balancing cell growth and product synthesis for efficient microbial cell factories. ADVS, 12(40), e10649. (www)

  @article{ , abstract = {The sustainable, bio-based production of industrially valuable chemicals and materials from renewable, non-edible biomass through biorefineries has emerged as a vital strategy for tackling urgent global challenges, including climate change, and for realizing the “net zero carbon” commitments recently pledged by nations worldwide. Metabolic engineering has played a central role in enabling the development of microbial strains capable of efficiently overproducing a diverse array of target compounds. Nevertheless, engineered microbial cell factories often face inherent trade-offs between product synthesis and cell growth, frequently resulting in diminished fitness or loss-of-function phenotypes. This review highlights recent advances in metabolic engineering strategies aims at reconciling this conflict, encompassing pathway optimization, dynamic regulation, orthogonal system design, microbial consortia engineering, fermentation process control, and integrative metabolic modeling. It also explores the remaining challenges and future directions for reprogramming microbial metabolism to harmonize growth with high-level production.}, archive = {J_ADVS}, author = {Linxia Liu and Dongqin Ding and Huiying Wang and Xinyi Ren and Sang Yup Lee and Dawei Zhang}, doi = {10.1002/advs.202510649}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10649}, shortjournal = {Adv. Sci.}, title = {Balancing cell growth and product synthesis for efficient microbial cell factories}, volume = {12}, year = {2025}, }
• (2025). High electrical conductivity induced by surface confinement effect in heterostructured multifunctional nanofiber composite films for low-reflection electromagnetic interference shielding. ADVS, 12(40), e10386. (www)

  @article{ , abstract = {Electromagnetic interference (EMI) shielding films with low-reflection characteristics are ideal for blocking electromagnetic(EM) radiation and pollution. Poly(vinyl alcohol-co-ethylene) (PVA-co-PE) nanofibers, with high specific surface area and abundant active groups, can be compounded with various conductive materials to prepare EMI shielding materials with low-reflection features. However, the large-scale industrial application of such shielding materials with multifunctionality remains rarely explored. 1D silver nanowires (AgNW) and 2D MXene are tend to form 3D network structure, and their magnetoelectric synergistic effect can significantly enhance the energy loss of EM waves. In this study, heterostructured PVA-co-PE/AgNW/MXene (PAM x ) composite films are prepared via a two-step spray coating and solvent evaporation method. This method achieves the denseness of AgNW/MXene on the film surface through the surface confinement effect, significantly improving the utilization rate of conductive media. A 5.4 wt.% AgNW/MXene content, the EMI shielding efficiency (EMI SE), normalized SE (EMI SE/t), and absolute SE (SSE/t) are 60.2 dB, 5452.9 dB·cm −1 and 36352.7 dB·cm 2 ·g −1 in the ultra-wide frequency of 8–20 GHz, along with an extremely low reflection coefficient (R = 0.13). The straightforward preparation process makes it highly suitable for industrial-scale production, showing significant potential in aerospace, flexible wearables fields.}, archive = {J_ADVS}, author = {Dechang Tao and Xin Wen and Shuai Ma and Can Chen and Jianing Guo and Wenwen Wang and Kun Yan and Chenguang Yang and Dong Wang}, doi = {10.1002/advs.202510386}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10386}, shortjournal = {Adv. Sci.}, title = {High electrical conductivity induced by surface confinement effect in heterostructured multifunctional nanofiber composite films for low-reflection electromagnetic interference shielding}, volume = {12}, year = {2025}, }
• (2025). Ultrafast self-driven WSe2 photodetectors with bottom schottky contacts. ADVS, 12(40), e10373. (www)

  @article{ , abstract = {Conventional top-contact two dimensional (2D) Schottky photodetectors suffer from light shadowing and contact damage, leading to Fermi-level pinning and performance degradation. This work overcomes these limitations by designing a bottom-electrode Schottky photodetector (BE-Schottky PD) based on a Cr/WSe 2 /Au heterostructure. The key innovation involves fabricating the bottom Schottky Cr electrode into pre-etched SiO 2 substrate trenches, making it flush with the surface. This unique geometry eliminates optical shadowing to maximize light absorption, and enables a high-quality van der Waals Cr/WSe 2 interface, mitigating Fermi-level pinning. Consequently, the device exhibits an outstanding rectification ratio of 1.07 × 10 4 and an ideality factor of 1.11 due to the strong built-in electric field. It demonstrates excellent self-powered operation within the visible spectrum. Under 532 nm laser illumination and zero bias, it achieves rapid photoresponse with a fall time of 3.8 µs. This work, utilizing industry-compatible metals and a simple process, realizes a high-performance photodetector, highlighting the significant potential of 2D materials for efficient, low-power, and ultrasensitive optoelectronics.}, archive = {J_ADVS}, author = {Jian Li and Zhihao Wang and Jialing Jian and Zhengjin Weng and Qianqian Wu and Xingyu Zhou and Liangliang Lin and Xiaofeng Gu and Peng Xiao and Haiyan Nan and Shaoqing Xiao}, doi = {10.1002/advs.202510373}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10373}, shortjournal = {Adv. Sci.}, title = {Ultrafast self-driven WSe2 photodetectors with bottom schottky contacts}, volume = {12}, year = {2025}, }
• (2025). Regulating pores and carbonyl groups of biomass-derived hard carbon for enhanced sodium storage. ADVS, 12(40), e10328. (www)

  @article{ , abstract = {This study investigates the impact of sulfuric acid-assisted hydrothermal pretreatment on the structural and electrochemical properties of biomass-derived hard carbon for sodium-ion batteries. Advanced characterization demonstrates that sulfuric acid-mediated hydrothermal strategy promotes the formation of crosslinked small molecules within the precursor. This process yields optimized hard carbon exhibiting pore-orifice nanoconfinement, enriched C═O functional groups at pore interface, and increased proportion of closed pores after carbonization. Collectively, these structural refinements synergistic enable exceptional sodium storage performance through accelerated desolvation kinetics, reduced nucleation energy barriers, and enhanced closed pore utilization efficiency to boost specific capacity. Specifically, the SAHTC-1300 anode delivers a remarkable reversible capacity of 386 mAh g −1 at 50 mA g −1 , maintains 270 mAh g −1 at 2 A g −1 , and retains 90% capacity after 1000 cycles at 1 A g −1 , outperforming control samples (HTC-1300 and SCG-1300). The work demonstrates the efficacy of sulfuric acid-assisted hydrothermal carbonization for synthesizing high-performance biomass-derived hard carbon anodes, offering valuable insights for the design of advanced biomass-based energy storage materials.}, archive = {J_ADVS}, author = {Chi Chen and Yapeng Tian and Run Ren and Shuocong Duan and Dandan Wang and Zhuosen Wang and Yunfeng Chao and Jianhua Zhu and Xinwei Cui}, doi = {10.1002/advs.202510328}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10328}, shortjournal = {Adv. Sci.}, title = {Regulating pores and carbonyl groups of biomass-derived hard carbon for enhanced sodium storage}, volume = {12}, year = {2025}, }
• (2025). Defect-rich porous cu with abundant cu(100) for acidic CO2 electroreduction in membrane electrode assembly. ADVS, 12(40), e10161. (www)

  @article{ , abstract = {Acidic electrocatalytic CO 2 reduction (CO 2 RR) faces slow C-C coupling kinetics and dominant hydrogen evolution, resulting in low C 2+ yields and selectivity. Here, the porous copper nanosheets (pCu NS) are reported with abundant Cu(100) and defect sites for efficient acidic CO 2 RR to C 2+ products. In a membrane electrode assembly (MEA), the pCu NS electrodes achieved a remarkable 75.01% C 2+ production Faradaic efficiency (FE) at a current density of 300 mA cm −2 with a full-cell voltage of 3.8 V. A CO 2 single-pass conversion efficiency of up to 74.38% is achieved. In situ Raman spectra and density functional theory calculations revealed that pCu NS not only gives abundant nanopores and defect sites but also preferentially exposes Cu(100) facets, synergistically creating local alkaline microenvironment, maximizing the *CO intermediate coverage, and promoting *CO hydrogenation for C 2+ production. This work offers a crucial insight for designing an efficient catalyst for efficient acidic CO 2 -to-C 2+ conversion.}, archive = {J_ADVS}, author = {Qiang Fang and Yunzhen Jia and Xuelei Lang and Geng Li and Tao Zhao and Dazhong Zhong and Jinping Li and Qiang Zhao}, doi = {10.1002/advs.202510161}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10161}, shortjournal = {Adv. Sci.}, title = {Defect-rich porous cu with abundant cu(100) for acidic CO2 electroreduction in membrane electrode assembly}, volume = {12}, year = {2025}, }
• (2025). Middle interlayer engineered ferroelectric NAND flash overcoming reliability and stability bottlenecks for next-generation high-density storage systems. ADVS, 12(40), e10155. (www)

  @article{ , abstract = {Multilevel storage and low-voltage operation position ferroelectric transistors as promising candidates for next-generation nonvolatile memory. Among them, gate-injection-type ferroelectric transistors offer improved vertical scalability and power efficiency for three-dimensional (3D) NAND flash. However, their intricate interplay between polarization switching and charge trapping complicates systematic understanding of degradation mechanisms, limiting strategies to improve reliability and stability. Here, gate stack engineering incorporating middle interlayers within HfZrO x matrix is presented to modulate polarization dynamics, strengthening the coupling of dual mechanisms and overcoming long-standing reliability and stability bottlenecks in ferroelectric NAND operation. This approach achieves a memory window up to 11 V, an operating voltage below 18 V, triple-level-cell retention beyond 10 years, disturbance immunity, and 54% reduced threshold voltage variability. A 20% reduction in program voltage compared to conventional NAND enables aggressive vertical scaling, leading to 25% higher bit-density. Furthermore, analytical modeling provides insights into gate stack optimization. These findings establish ferroelectric NAND as a scalable, energy-efficient solution for next-generation storage.}, archive = {J_ADVS}, author = {Giuk Kim and Sangho Lee and Hyojun Choi and Yangjin Jung and Woongjin Kim and Sanghyun Park and Kwangyou Seo and Kwangsoo Kim and Wanki Kim and Daewon Ha and Mincheol Shin and Jinho Ahn and Sanghun Jeon}, doi = {10.1002/advs.202510155}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10155}, shortjournal = {Adv. Sci.}, title = {Middle interlayer engineered ferroelectric NAND flash overcoming reliability and stability bottlenecks for next-generation high-density storage systems}, volume = {12}, year = {2025}, }
• (2025). Synthesis of functional materials using N-heterocyclic amines beyond melamine. ADVS, 12(40), e10137. (www)

  @article{ , abstract = {Melamine, a nitrogen-rich heterocycle with a 1,3,5-triazine core and three exocyclic amines, has played a central role in materials chemistry, enabling the synthesis of supramolecular assemblies, covalent organic polymers, and carbon nitride semiconductors. However, structurally related N-heterocyclic amines, differing in ring substitution or heterocycle, are far less applied in such fields despite their potential to overcome limitations associated with melamine-based materials. In this review, recent advances in the synthesis of covalent and carbon-based materials derived from melamine analogues, including 6-Phenyl-1,3,5-triazine-2,4-diamine, 6-Methyl-1,3,5-triazine-2,4-diamine and 2,4,6-Triaminopyrimidine are highlighted. It is focused on how variations in heterocycle identity and functional group substitution influence monomer reactivity, condensation behavior, and the resulting material properties, such as chemical composition, dimensionality, porosity and morphology. Diverse applications of such materials are discussed, from fluorescent sensing platforms to CO 2 capture and photo-electrocatalysis, however, the primary emphasis lies on synthetic strategies and structure-property relationships. It is concluded with a critical perspective on how these alternative building blocks, when leveraging sustainable synthesis methods coupled with emerging AI-guided materials discovery, may enable the targeted design of next-generation functional materials.}, archive = {J_ADVS}, author = {Jesús Barrio and Arne Thomas}, doi = {10.1002/advs.202510137}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10137}, shortjournal = {Adv. Sci.}, title = {Synthesis of functional materials using N-heterocyclic amines beyond melamine}, volume = {12}, year = {2025}, }
• (2025). Large-sized poly (Triazine imide) crystals with minimized defects for high-efficiency overall water splitting. ADVS, 12(40), e10084. (www)

  @article{ , abstract = {Poly (triazine imide) (PTI), a highly crystalline carbon nitride, has attracted considerable attention due to its capacity to achieve one-step-excitation overall water splitting. The crystallinity of PTI crystals can be substantially enhanced by manipulating the polymerization temperature and the type of molten salt. However, the particle size of synthetic crystals is usually less than 200 nm, and the synthesis of larger and well-defined PTI crystals has yet to be accomplished. In this study, a novel precursor engineering strategy is implemented utilizing melon-type carbon nitride as the architectural template, coupled with LiCl/KCl eutectic molten salt system, to orchestrate the crystallization of PTI under high-temperature/high-pressure conditions. Comparative analysis reveals that the PTI synthesized through this methodology exhibits marked crystallographic superiority over conventional dicyandiamide-derived counterparts, manifesting as notably reduced lattice imperfections and an extended π-conjugated network. These structural enhancements culminate in the formation of faceted single-crystalline domains with characteristic dimensions exceeding 500 nm. The optimized single-crystal PTI showcases a high apparent quantum efficiency of 13.1% (λ = 365 nm) in overall water splitting for hydrogen production. This work establishes the critical role of precursor architectural compatibility in governing crystalline perfection and functional performance in carbon nitride-based photocatalytic systems.}, archive = {J_ADVS}, author = {Chong Wang and Na Shi and Yulin Zhou and Yichun Lu and Jingru Zhuang and Hongwu Liao and Chengning Ye and Hanhui Lei and Xiangfeng Lin and Jiaxian Zheng and Terence Xiaoteng Liu and Zhanhui Yuan}, doi = {10.1002/advs.202510084}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10084}, shortjournal = {Adv. Sci.}, title = {Large-sized poly (Triazine imide) crystals with minimized defects for high-efficiency overall water splitting}, volume = {12}, year = {2025}, }
• (2025). Integrating metabolic modulation and nanomedicine for cancer immunotherapy. ADVS, 12(40), e10004. (www)

  @article{ , abstract = {Cancer cells undergo significant metabolic reprogramming to support rapid growth, survival under stress, and resistance to therapies. As our understanding of tumor metabolism and the tumor microenvironment (TME) deepens, there is growing interest in exploiting metabolic vulnerabilities as therapeutic strategies. This review explores key alterations in metabolic pathways, including glucose, amino acid, lipid, nucleotide metabolism, and mitochondrial function, and highlights their impact on tumor progression, the TME, and immune cell function. In addition, the review discusses emerging strategies aimed at targeting these metabolic pathways with a focus on nanomaterial-based therapies. This includes the use of nanoparticles and drug delivery systems designed to modulate immunometabolism within cancer. These innovative approaches aim to reprogram the TME, enhance immune responses, and improve the targeted delivery of therapeutic agents to tumor sites, offering new ways to overcome conventional therapeutic resistance. Finally, the review also addresses the foreseeable challenges and potential future developments in this field, outlining the opportunities and obstacles that must be addressed for the clinical translation of these strategies in cancer therapy.}, archive = {J_ADVS}, author = {Xiaosu Zhou and Ruibing Deng and Zunde Liao and Xiaoyu Huang and Junting Huang and Hanlou Yang and Kam W. Leong and Yiling Zhong}, doi = {10.1002/advs.202510004}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e10004}, shortjournal = {Adv. Sci.}, title = {Integrating metabolic modulation and nanomedicine for cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Hologenomics reveals specialized dietary adaptations in the mengla snail-eating snake. ADVS, 12(40), e09999. (www)

  @article{ , abstract = {Serpents, as highly adaptable vertebrates, provide robust models for studying the mechanisms of dietary specialization. Using an integrative multi-omics approach, encompassing host genomic, transcriptomic, proteomic, gut metagenomic, and enzymatic analyses, the mechanisms underlying dietary adaptations in the Mengla snail-eating snake ( Pareas menglaensis ), a species specialized in consuming snails is investigated. Adaptations supporting this diet included evolution of infralabial glands secreting toxin homologs and digestive enzymes, facilitating molluscan predation and digestion. This specialization has driven adaptive evolution in the host genome and shaped the gut microbiota, addressing both nutritional challenges (e.g., lipid deficiency) and digestive requirements (e.g., mucus degradation) associated with snail consumption. Notably, the functional convergence in microbial gene functions between reptiles and mammals highlights parallel evolutionary pathways in dietary specialization. These findings elucidate the genomic foundations of dietary specialization in P. menglaensis , offering broader insights into evolutionary adaptation within a holobiome framework.}, archive = {J_ADVS}, author = {Chaochao Yan and Xin-Ning Li and Zhong-Liang Peng and Wei Wu and Zeng Wang and Zhao-Ran Zhu and Jia-Chang Liu and Yao Wang and Jin-Long Ren and Zhi-Yi Zhang and Jia-Tang Li}, doi = {10.1002/advs.202509999}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09999}, shortjournal = {Adv. Sci.}, title = {Hologenomics reveals specialized dietary adaptations in the mengla snail-eating snake}, volume = {12}, year = {2025}, }
• (2025). Spatially separated molecular activation over dual sites in sn-doped ZnGa2O4/SnO2 photocatalysts toward complete VOCs mineralization. ADVS, 12(40), e09891. (www)

  @article{ , abstract = {Photocatalysis holds great promise for air pollutant remediation; however, its efficiency is often limited by charge recombination and humidity interference. Herein, Sn-doped ZnGa 2 O 4 loaded SnO 2 nanoparticles (SZGO) is in situ constructed via a one-step hydrothermal method. The doped Sn atoms act as electron-trapping centers and form interfacial Sn─O channels between ZnGa 2 O 4 and SnO 2 , enabling directional electron migration. Hydrophilic ZnGa 2 O 4 domains selectively adsorb H 2 O, generating hydroxyl radicals (·OH) that facilitate aromatic ring cleavage, while electron-rich SnO 2 domains activate O 2 to produce superoxide (·O 2 − ) and singlet oxygen ( 1 O 2 ), leading to complete degradation of carbonaceous intermediates. The optimized SZGO achieves nearly 100% toluene degradation and 99.2% mineralization efficiency, with excellent stability across a wide humidity range (0–100%) and over 12 continuous cycles (720 min). Additionally, SZGO demonstrates broad-spectrum reactivity toward other volatile organic compounds (VOCs), such as acetone and formaldehyde. This work offers a versatile design strategy that couples directional charge transport with site-specific molecular activation, providing new insights for the development of highly stable photocatalysts for environmental purification.}, archive = {J_ADVS}, author = {Xianli Hu and Bin Liu and Hao Ma and Ruimei Fang and Ting Zhang and Yuhan Li and Behzad Rezaei and Fan Dong}, doi = {10.1002/advs.202509891}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09891}, shortjournal = {Adv. Sci.}, title = {Spatially separated molecular activation over dual sites in sn-doped ZnGa2O4/SnO2 photocatalysts toward complete VOCs mineralization}, volume = {12}, year = {2025}, }
• (2025). Energy deficiency-induced ATG4B nuclear translocation inhibits PRMT1-mediated DNA repair and promotes leukemia progression. ADVS, 12(40), e09838. (www)

  @article{ , abstract = {Metabolic alterations and genomic instability are the hallmark features of many cancers. However, the precise mechanisms underlying the intricate links among these processes remain largely unknown. Here, a molecular mechanism is presented that regulates the interplay between cellular energy metabolism and DNA repair. These findings demonstrate that during energy deficiency, ATG4B translocates from the cytoplasm to the nucleus and disrupts DNA repair by directly interacting with PRMT1. This interaction inhibits the PRMT1-dependent methylation of MRE11, a key regulator of DNA repair, leading to genomic instability. Importantly, it is shown that ATG4B-mediated DNA repair defects are significantly enhanced in patient-derived acute myeloid leukemia (AML) cells and in mouse AML cells induced by MLLT3-KMT2A overexpression. Inhibition of ATG4B enhanced PRMT1-mediated DNA damage responses, suppressed cell proliferation, reduced the mutation burden, and prolonged survival in mice with MLLT3-KMT2A-induced AML and in those bearing AML patient-derived xenografts. These findings revealed that energy deficiency compromises DNA repair through ATG4B nuclear translocation, and ATG4B inhibition enhances DNA repair in AML cells, alleviating the malignant evolution of AML.}, archive = {J_ADVS}, author = {Zhenkun Wang and Xianli Zhang and Yuanyuan Zhou and Shuyi Lin and Yuting Fu and Haiping Liu and Qiongdan Gao and YanHong Xiao and Zhao Yin and Shuang Liu and Kexiu Huang and Suqi Deng and Juan Du and Hui Zeng and Jia Wang and Jinping Zheng and Qinghua Zhou and Tianfeng Chen and Xiaoling Gao and Zhenyu Ju and Bo Liu}, doi = {10.1002/advs.202509838}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09838}, shortjournal = {Adv. Sci.}, title = {Energy deficiency-induced ATG4B nuclear translocation inhibits PRMT1-mediated DNA repair and promotes leukemia progression}, volume = {12}, year = {2025}, }
• (2025). Tailoring regioselectivity-controlled UDP-glycosyltransferase for bidirectional glycosylation of tyrosol via free energy-driven pocket reshaping and tunnel engineering. ADVS, 12(40), e09814. (www)

  @article{ , abstract = {UDP-glycosyltransferases (UGTs) are pivotal biocatalysts for synthesizing pharmaceutically valuable active components; however, their application is frequently constrained by poor regioselectivity and suboptimal catalytic efficiency. In this study, a tailored, free energy-driven, substrate-binding pocket reshaping strategy is implemented to pinpoint the specific residues in UGT BL 1 that control bidirectional regioselective glycosylation of tyrosol, enabling the synthesis of salidroside and icariside D2 without the need for large-scale screening. Additionally, modifications in the tunnel lead to two strictly regioselective mutants with improved catalytic efficiency due to the faster release of the products. Remarkably, while wild-type UGT BL 1 exhibits poor regioselectivity toward the alcoholic and phenolic hydroxyl groups of tyrosol, generating an almost equal mixture of products (1:1 ratio), mutant M2 achieved 99.2% regioselectivity toward the alcoholic hydroxyl group of tyrosol, coupled with a 14.8-fold enhancement in catalytic efficiency for salidroside production. Similarly, mutant M2-1 displays 99.1% regioselectivity toward the phenolic hydroxyl group, along with a 3.6-fold improvement in catalytic efficiency for icariside D2 synthesis. Molecular dynamics simulations reveal details about the mechanism for improved regioselectivity and catalytic efficiency. This work provides important insights for protein engineering of UDP-glycosyltransferase with the spacious active pocket in constructing small but smart mutant libraries.}, archive = {J_ADVS}, author = {Ziyu Zhang and Jingyi Chen and Zuozhi Liang and Wenming Shao and Zhen Gao and Bin Wu and Bingfang He and Gerhard Schenk}, doi = {10.1002/advs.202509814}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09814}, shortjournal = {Adv. Sci.}, title = {Tailoring regioselectivity-controlled UDP-glycosyltransferase for bidirectional glycosylation of tyrosol via free energy-driven pocket reshaping and tunnel engineering}, volume = {12}, year = {2025}, }
• (2025). Bio-inspired stored magnetic energy actuator with transient triggering and programmable logic. ADVS, 12(40), e09683. (www)

  @article{ , abstract = {Smart actuators generally face the problems of limited response speed, dependence on external energy supply, and lack of multi-environmental signal logic judgment capability. Therefore, this study proposes a new paradigm of bionic magnetic energy actuator, which realizes high-speed autonomous response without external energy source by fusing magnetic transient triggering with programmable environmental logic gating strategy. Based on direct ink writing 3D printing technology, an integrated structure of “magnetic energy storage-environmental unlocking” is constructed by combining the directional magnetization design of a hard magnetic material (NdFeB/polydimethylsiloxane) with an environment-responsive locking material (phase-change wax, polyvinylpyrrolidone/ethanol solution). This structure synergizes the slow response of environmental signals with the transient release of magnetic energy at millisecond level, and the release rate of magnetic energy is several orders of magnitude higher than that of the traditional stimulus-responsive actuator; meanwhile, based on the biomimetic “and gate” logic coding, the precise conditional judgment of time-sequential environmental signals (e.g., “high temperature → rain”) has been realized. The results show that the actuator can simulate high-speed seed ejection, multimodal gripping, and logic-gated bouncing behaviors of biological prototypes. This research provides new ideas for environmentally adaptive robots in wild scenarios, with potential applications in ecological restoration and precision agriculture.}, archive = {J_ADVS}, author = {Chao Xu and Shuo Jiang and Lu Zhang and Xueli Zhou and Qingping Liu and Luquan Ren}, doi = {10.1002/advs.202509683}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09683}, shortjournal = {Adv. Sci.}, title = {Bio-inspired stored magnetic energy actuator with transient triggering and programmable logic}, volume = {12}, year = {2025}, }
• (2025). Adaptive mechanical metamaterials with on-demand binary local modulus for embodied intelligence. ADVS, 12(40), e09675. (www)

  @article{ , abstract = {Biological materials in nature are inherently adaptive, evolving through continuous interaction with their environment. Achieving such adaptability and self-optimization in artificial materials remains a major challenge. In this work, a simple yet robust mechanism is introduced that enables instantaneous changes in local stiffness components in response to strain. This is realized by designing binary meta-capsules with two discrete states 0 and 1, each corresponding to a different modulus in one direction. These strain-responsive capsules switch states based on applied deformation, serving as the building blocks for a new class of adaptive mechanical metamaterials (AMMs). Computational tools are developed to guide the design, and selected structures are fabricated via multi-material polymer jetting. Mechanical experiments, including compression and indentation tests, confirm the functionality of the AMMs. Because the stiffness change in each meta-capsule is reversible, the material can reconfigure itself after loading-unloading cycle. This enables AMMs to dynamically adjust their local properties based on external loads and/or constraints, effectively “reprogramming” or redesigning themselves post-fabrication, paving the way for transforming 3D/4D printing into adaptive, “infinity-D” printing.}, archive = {J_ADVS}, author = {Richard J. Nash and Yunzheng Yang and Yaning Li}, doi = {10.1002/advs.202509675}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09675}, shortjournal = {Adv. Sci.}, title = {Adaptive mechanical metamaterials with on-demand binary local modulus for embodied intelligence}, volume = {12}, year = {2025}, }
• (2025). A wearable electrochemical biosensor for salivary detection of periodontal inflammation biomarkers: Molecularly imprinted polymer sensor with deep learning integration. ADVS, 12(40), e09658. (www)

  @article{ , abstract = {The work presented here introduces a developed electrochemical biosensor for the salivary detection of matrix metalloproteinase-8 (MMP-8), utilizing a molecularly imprinted polymer (MIP) matrix based on poly(o-phenylenediamine). To enhance detection sensitivity and modulate impedance responses, graphene oxide (GO) is incorporated as an interlayer, providing a conductive and chemically stable matrix for precise electrochemical sensing. Density functional theory simulations confirm the formation of highly selective binding sites, further reinforcing the sensor's specificity for MMP-8 detection. The impedance-based mechanism allows real-time, label-free detection of salivary MMP-8 by tracking charge transfer resistance changes via the K[Fe(CN)₆] 3 ⁻/⁴⁻ redox probe, offering a non-invasive and highly sensitive alternative to conventional methods. Clinical validation using patient samples demonstrates excellent sensor performance, achieving high specificity and reproducibility. Additionally, a deep learning-assisted data analysis framework is integrated to enhance diagnostic accuracy by filtering out noise, identifying disease progression trends. Furthermore, a wearable mouthguard platform integrating the MIP-based electrode, enabling continuous monitoring of oral inflammation and facilitating early therapeutic intervention is developed. This approach, which combines MIP technology, electrochemical biosensing, wearable healthcare, and AI-driven diagnostics, has the potential to establish a next-generation precision oral health monitoring platform, advancing periodontal disease detection and personalized clinical management.}, archive = {J_ADVS}, author = {Sangheon Jeon and Sung Hyun Kim and Gyeonghwa Heo and Hye Jin Heo and Seon Yeong Chae and Young Woo Kwon and Shin-Kyu Lee and Dong-Wook Han and Hyun-Joo Kim and Yun Hak Kim and Suck Won Hong}, doi = {10.1002/advs.202509658}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09658}, shortjournal = {Adv. Sci.}, title = {A wearable electrochemical biosensor for salivary detection of periodontal inflammation biomarkers: Molecularly imprinted polymer sensor with deep learning integration}, volume = {12}, year = {2025}, }
• (2025). Chinese nian gao inspired textured janus hydrogel for body signal sensing and human machine interaction. ADVS, 12(40), e09573. (www)

  @article{ , abstract = {Inspired by Chinese Nian Gao, a traditional food in China, a skin-like bio-hydrogel with asymmetric Janus adhesion and textured structures on its surface is fabricated via a one-pot strategy and is evaluated as electronic skin for sensing and human–machine interaction. The e-skin is constructed through hydrogen bonding and metal-ligand coordination with favorable toughness and stretchability (tensile strength of 173 kPa, strain of 1593%). The bottom surface of the e-skin reached an adhesion strength of 66.7 kPa, and the upper surface shows no adhesion on different substrates, which ensures the stable signal collection on the bottom and avoids interference from incidental contact with clothing or external objects on the upper side. The skin-mimic textures are created in drying, which endows the hydrogel with visual authenticity comparable to biological skin; consequently, it can be used for human scar coverage and skin encapsulation of humanoid robots. The e-skin has an outstanding biocompatibility as well as a high self-healing efficiency of 93.5% and it is developed and demonstrated for multipurpose real-time applications. Furthermore, it accurately identifies hand gestures to control an assistive robotic arm in real-time based on EMG and EEG signals, highlighting its potential in next-generation aesthetic and functional wearable electronics.}, archive = {J_ADVS}, author = {Haiyu Li and Hui Zhang and Xinxin Liu and Jing Jie and Ming Yin and Jie Du}, doi = {10.1002/advs.202509573}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09573}, shortjournal = {Adv. Sci.}, title = {Chinese nian gao inspired textured janus hydrogel for body signal sensing and human machine interaction}, volume = {12}, year = {2025}, }
• (2025). Aptamer-mediated artificial synapses for neuromorphic modulation of inflammatory signaling via organic electrochemical transistor. ADVS, 12(40), e09545. (www)

  @article{ , abstract = {Artificial synaptic devices that mimic neuromorphic signal processing hold great promise for bioelectronic interfaces. However, most systems remain limited to physical stimuli or electroactive small molecules, lacking the ability to transduce biologically relevant protein signals. To address this limitation, an aptamer-mediated aqueous artificial synaptic transistor is developed capable of selectively responding to the interleukin-6 (IL-6) signal, a specifically expressed protein of inflammatory stress, via gate-voltage-induced synaptic modulation in biologically relevant electrolyte environments. Guided by molecular docking simulations, high-affinity aptamer sequences are identified for robust recognition of IL-6. The device demonstrates precise IL-6 capture and translation into neuromorphic electrical signals across various biological electrolytes (PBS, albumin, serum), with linear detection from 0.5 p m to 50 n m . Moreover, the device can convert IL-6 binding events into time and concentration-dependent electrical outputs, exhibiting significant synaptic plasticity and memory retention. When implanted into the caudal vein of sepsis mice, the device stably monitors IL-6 level and maintains reliable synaptic response to inflammatory-triggered elevations. Machine learning analysis enables accurate discrimination between normal and pathological states from device-generated signals. By bridging biochemical signals with neuromorphic encoding, this system outlines a conceptual framework for future integration between artificial and biological neural units, contributing to the hybrid neurosensory systems.}, archive = {J_ADVS}, author = {Yuqing Ding and You Kuai and Rongpei Li and Xinzhao Xu and Bo Wang and Zhihui Wang and Yanfang Liu and Yuchao Dong and Shunjie Chen and Meng Guo and Yunqi Liu and Yan Zhao}, doi = {10.1002/advs.202509545}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09545}, shortjournal = {Adv. Sci.}, title = {Aptamer-mediated artificial synapses for neuromorphic modulation of inflammatory signaling via organic electrochemical transistor}, volume = {12}, year = {2025}, }
• (2025). Supramolecular hydrogel showing mechanical robustness and good adhesion underwater. ADVS, 12(40), e09542. (www)

  @article{ , abstract = {Underwater adhesive materials hold significant application value in fields such as biomedicine and marine engineering. The core performance of these materials lies in the synergistic optimization of their mechanical properties and interfacial adhesive strength. Although supramolecular hydrogels have achieved initial breakthroughs through dynamic bond design, they fail to be mechanically tough and favorably adhesive underwater at the same time. To address this challenge, a strategy to fabricate a supramolecular hydrogel with high crosslinking density using 3D printing technology is proposed. The obtained hydrogel demonstrates excellent mechanical strength due to its high-density hydrogen bonding crosslinks that it retains a tensile stress of 4 MPa and can support a 20 g load without deformation after submersion in water for 30 min. Meanwhile, it displays remarkable self-adhesion property underwater, achieving an interfacial adhesion strength of 690 kPa following 20 min of contact duration. Notably, the hydrogel manifests versatile underwater adhesion capabilities to various substrates. Therefore, a supramolecular hydrogel that integrates both good mechanical performance and adhesion underwater characteristics is successfully developed. In addition, modular soft robots are also constructed using this hydrogel, which is able to successfully complete various underwater missions.}, archive = {J_ADVS}, author = {Xiaohe Zhou and Yihan Cui and Rui Hu and Xiaofan Ji}, doi = {10.1002/advs.202509542}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09542}, shortjournal = {Adv. Sci.}, title = {Supramolecular hydrogel showing mechanical robustness and good adhesion underwater}, volume = {12}, year = {2025}, }
• (2025). ASH2L-k312-lac stimulates angiogenesis in tumors to expedite the malignant progression of hepatocellular carcinoma. ADVS, 12(40), e09477. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) is a common malignant tumor. However, the role of lactic acid–modified proteins in its pathogenesis is unclear. This study determines the distribution of a novel post-translational modification—protein lactylation—in HCC to identify potential targets and obtain mechanistic insights into this disease. Using high-throughput proteomics, lysine 312 lactylation (K312-lac) of the Set1/Ash2 histone methyltransferase complex subunit (ASH2L) is revealed as a candidate for further investigation. Subsequently, alanyl-tRNA synthetase 1 (AARS1) and histone deacetylase 1 (HDAC1) are shown to mediate lactylation modification of ASH2L. In vivo experiments demonstrate that ASH2L-K312-lac promotes HCC malignant progression and is positively correlated with tumor microvessel density, and vascular endothelial growth factor A (VEGFA) is identified as the key mediator in ASH2L-K312-lac-induced angiogenesis. High-throughput sequencing reveals ASH2L-K312-lac enrichment in the genome regions encoding VEGFA , facilitating targeted recruitment of the mixed lineage leukemia complex to these loci and enhancing VEGFA expression through synergistic activation of enhancers and promoters. Finally, clinical sample analyses and robust in vivo preclinical experiments identify ASH2L-K312-lac as a promising therapeutic target for clinical application. These findings provide a theoretical foundation for the clinical translation of ASH2L-K312-lac-based treatment approaches, offering potential advancements in HCC diagnosis and treatment.}, archive = {J_ADVS}, author = {Hexu Han and Shuai Wang and Lixing Ma and Haimeng Yin and Xinxiang Cheng and YiFan Wang and Suqin Xia and Yi Zhang and Yue Zhang and Rong Zhu and Cuixia Liu and Dakun Zhao and Xiangqian Gu and He Zhu and Yin Yuan}, doi = {10.1002/advs.202509477}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09477}, shortjournal = {Adv. Sci.}, title = {ASH2L-k312-lac stimulates angiogenesis in tumors to expedite the malignant progression of hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Strategically constructing alkali-metal interfacial bridges to boost photocatalytic CO2 methanation on supported Ni─Ru bimetallic catalysts. ADVS, 12(40), e09454. (www)

  @article{ , abstract = {Efficient photocatalytic conversion of CO 2 into CH 4 is crucial yet challenging due to the complex multi-electron transfer processes and sluggish intermediate transformation. Herein, an innovative strategy is introduced to dramatically enhance photocatalytic CO 2 methanation by constructing interfacial alkali-metal bridges (Na inter ) between Ni and Ru nanoparticles over ZrO 2 surface. By selectively introducing and subsequently removing excessive surface Na species, stable interfacial Na species are retained, forming a distinctive Ni 0 ─Ni δ+ ─Na inter ─O─Ru electronic bridge. Comprehensive structural and electronic characterizations (XRD, TEM, XAFS, XPS, DRIFTS) demonstrate that the interfacial Na bridge significantly improves electronic communication between Ni and Ru, enhances charge separation efficiency, optimizes CO 2 adsorption, and lowers activation barriers for key intermediates. As a result, the optimized catalyst (0.2Na─Ni─Ru/ZrO 2 ) achieves an exceptionally high CH 4 production rate of 1882.7 µmol·g −1 ·h −1 , ≈15-fold that of the Na-free catalyst, with excellent stability and durability. DFT calculations reveal that the Na inter site effectively stabilizes reactive intermediates, greatly accelerating formate to CO conversion and reshaping the reaction pathway. This work highlights alkali-metal-mediated interfacial engineering as a versatile approach to enhance the synergy in multi-component catalysts, opening a new avenue for advanced photocatalytic CO 2 reduction.}, archive = {J_ADVS}, author = {Xiaolei Guo and Yuqi Wu and Shengrong Zhou and Yuhang Shao and Yasuo Izumi and Jinlu He and Hongwei Zhang}, doi = {10.1002/advs.202509454}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09454}, shortjournal = {Adv. Sci.}, title = {Strategically constructing alkali-metal interfacial bridges to boost photocatalytic CO2 methanation on supported Ni─Ru bimetallic catalysts}, volume = {12}, year = {2025}, }
• (2025). Metalloporphyrin/Phthalocyanine catalysts for electrocatalytic nitrogen fixation. ADVS, 12(40), e09323. (www)

  @article{ , abstract = {Metalloporphyrin/phthalocyanine complexes serve as excellent electrocatalytic models due to their well-defined MN 4 , structural tunability, and chemical stability. They have been applied in many catalytic fields and have shown excellent catalytic activity, such as oxygen reduction reaction (ORR) and carbon dioxide reduction reaction (CO 2 RR), etc. The application of these complexes in electrocatalytic nitrogen fixation, such as nitrogen reduction reactions (NRR), nitrate reduction reactions (NO 3 RR), nitrite reduction reactions (NO 2 RR), and nitrate/nitrite/nitrogen-carbon dioxide co-reduction (N 2 /NO x -CO 2 RR) for urea production, has been emphasized in recent years. The main obstacles for these complexes to function effectively as electrocatalysts involve the necessity for a well-thought-out design of porphyrin/phthalocyanine structures and a more comprehensive understanding of their structure-activity relationships. This review summarizes the modifying porphyrin/phthalocyanine complex methods, constructing derivative strategies, and exploring the relevant electrocatalytic reaction mechanisms and their applications for electrocatalytic nitrogen fixation. Optimization strategies based on reaction mechanisms and catalytic performance are proposed. Finally, this comprehensive overview aims to provide professional insights that will guide future experimental and theoretical advancements in porphyrin/phthalocyanine complexes and highlight their challenges and prospects for electrocatalytic systems.}, archive = {J_ADVS}, author = {Hai Sun and Shun Lu and Yuanyuan Qi and Jiahui Wu and Terence Liu and Jun-Sheng Qin and Heng Rao}, doi = {10.1002/advs.202509323}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09323}, shortjournal = {Adv. Sci.}, title = {Metalloporphyrin/Phthalocyanine catalysts for electrocatalytic nitrogen fixation}, volume = {12}, year = {2025}, }
• (2025). High-speed design of multiplexed meta-optics enabled by physics-driven self-supervised network. ADVS, 12(40), e09242. (www)

  @article{ , abstract = {The artificial intelligence (AI) can accelerate the meta-optics design by rapidly predicting the transmission coefficients of individual meta-atoms. However, extensive optimization iterations are usually required to complete the desired metasurface consisting of massive meta-atoms. For designing meta-holography, any change to the target image forces the whole process to repeat, resulting in lengthy computation time. Here, a physics-driven self-supervised network (PDSS-Net) built upon AI-assisted optimization frameworks are proposed to further expedite the design process. The encoder-decoder module introduced into the PDSS-Net can establish a mapping between the input holographic images and the output structural parameters of all meta-atoms. After self-supervised training, the network learns this mapping and enables iteration-free inference for inputs beyond the training dataset. The design of 2K-resolution, three-wavelength-multiplexed meta-holograms is completed within one second, achieving a computational speedup exceeding 1000-fold over conventional optimization-based approaches. By retraining, more complex tasks are achieved as demonstrated in the design of both the wavelength-polarization-depth multiplexed scalar and vectorial meta-holograms. This iteration-free computational paradigm with adaptability in typical multiplexed meta-optics can be applied to the intelligent design of multifunctional metasurfaces, facilitating large-scale applications of meta-devices.}, archive = {J_ADVS}, author = {Yuqing He and Sheng Ye and Yue Han and Mingna Xun and Qiang Li and Ruiqi Wang and Qihuang Gong and Yan Li}, doi = {10.1002/advs.202509242}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09242}, shortjournal = {Adv. Sci.}, title = {High-speed design of multiplexed meta-optics enabled by physics-driven self-supervised network}, volume = {12}, year = {2025}, }
• (2025). Cation-engineered gradient interfacial structure toward dendrite-free and shuttle-free aqueous zn-iodine batteries. ADVS, 12(40), e09239. (www)

  @article{ , abstract = {Uncontrolled dendrite growth, water-induced side reactions, and polyiodide shuttling remain critical in aqueous Zn-iodine batteries (AZIBs). Herein, an “electric double layer (EDL)-directed regulator” strategy utilizing amphiphilic acetylcholine cation (ACh + ) as interfacial modifiers is proposed. The directed adsorption of ACh + on the Zn anode surface assembles a hydrophobic-hydrophilic gradient interfacial structure. The hydrophobic inner layer establishes a water-poor EDL structure, reducing direct Zn-electrolyte contact and suppressing side reactions. Meanwhile, the hydrophilic outer layer disrupts the original H 2 O-H 2 O within EDL structure, lowering water activity and reducing the Zn 2+ desolvation energy barrier. When coupled with an I 2 cathode, dissolvable polyiodide anions are captured by ACh + via electrostatic interactions, effectively inhibiting the polyiodide shuttles. Consequently, the Zn anode with optimized EDL delivers a high Coulombic efficiency (CE) of 99.82%, with remarkable stability over 3700 h at 1.0 mA cm −2 /1.0 mAh cm −2 and 1500 h at 10 mA cm −2 /1.0 mAh cm −2 . Moreover, the Zn-I 2 full cell exhibits an ultralow capacity decay rate of merely 0.000512% per cycle over 25000 cycles at 2.0 A g −1 . This work provides an effective EDL regulation strategy for optimizing the Zn anode interfacial chemistry toward the advanced AZIBs.}, archive = {J_ADVS}, author = {Jiayi Li and Xiao Zhang and Xinming Xu and Bingqing Xie and Yuchun Wang and Long Su and Hansen Wang and Chuying Ouyang and Xinpei Gao}, doi = {10.1002/advs.202509239}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09239}, shortjournal = {Adv. Sci.}, title = {Cation-engineered gradient interfacial structure toward dendrite-free and shuttle-free aqueous zn-iodine batteries}, volume = {12}, year = {2025}, }
• (2025). Novel swelling-lytic cell death triggered by cargo-free ionizable lipid nanoparticles. ADVS, 12(40), e09208. (www)

  @article{ , abstract = {Lipid nanoparticles (LNPs) are recognized as robust and versatile drug delivery platforms holding significant promise for personalized and precision medicine applications. However, their intrinsic biological effects, including dose-limiting toxicity and acute inflammation, limit their widespread application. Elucidating the underlying mechanisms paradoxically enables dual-path optimization: targeted mitigation strategies for adverse effects and deliberate amplification of adverse effects for repurposing (“waste-to-resource”). Here, cargo-free lipid nanoparticles containing the ionizable phospholipid IP9 (ipLNP) are found to induce broad swelling (bubble) morphology and lytic cell death across multiple cell types. ipLNP-induced cell death involves reactive oxygen species (ROS) increase, lipid peroxidation, and GSDME cleavage, but is only inhibited by vitamin E among the tested inhibitors. By exploring the effects of vitamin E, lysosome-associated lytic cell death is found to be triggered by ipLNP and mediated by lysosome membrane destabilization. Moreover, ipLNP exhibits remarkable potential as novel Th1/Th17-directing vaccine adjuvants and emerging cancer therapeutic agents, not merely as drug carriers.}, archive = {J_ADVS}, author = {Junjun Wu and Zhennan Zhao and Hongsheng Wu and Sihuang Lin and Lin Huang and Guanjie Chen and Yi Yang and Hong Wang and Huijie Yan and Yonghui Shi and Liuyu Zhu and Guosheng Hu and Liling Zheng and Songying Ouyang}, doi = {10.1002/advs.202509208}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09208}, shortjournal = {Adv. Sci.}, title = {Novel swelling-lytic cell death triggered by cargo-free ionizable lipid nanoparticles}, volume = {12}, year = {2025}, }
• (2025). Strategic mobility engineering in 2D semiconductor-based FETs for enhanced electronic devices. ADVS, 12(40), e09170. (www)

  @article{ , abstract = {As silicon-based electronics approach the physical limits of Moore's Law, 2-Dimensional (2D) semiconductors emerge as promising candidates for next-generation electronic devices due to their atomic-scale thickness and inherently high carrier mobilities. These materials offer superior electrostatic control, mitigating short-channel effects while enabling continued device scaling. However, challenges such as contact resistance and suboptimal channel properties continue to impede carrier transport, necessitating advanced mobility engineering strategies. This review comprehensively evaluates recent approaches to enhance carrier mobility in 2D semiconductor-based field-effect transistors (FETs), including doping, metal-semiconductor interface optimization, effective mass engineering, scattering mechanism manipulation, work function tuning, and strain engineering. These strategies improve critical device parameters like current drive, subthreshold swing, and on/off ratios by optimizing carrier transport efficiency. By linking material-level advancements to circuit-level performance, this work underscores the pivotal role of mobility engineering in enabling scalable, high-performance 2D electronics. These insights pave the way for transitioning 2D materials from laboratory research to practical applications, overcoming the limitations of conventional silicon technologies and driving innovations in high-performance, energy-efficient electronics.}, archive = {J_ADVS}, author = {Sheila Sim and Sichao Li and Weifan Cai and Baiyu Yu and Xin Ju and Jing Cao and Zhaogang Dong and Xinmao Yin and Sunmi Shin and Yue Luo and Dongzhi Chi and Ady Suwardi and Hong Kuan Ng and Jing Wu}, doi = {10.1002/advs.202509170}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09170}, shortjournal = {Adv. Sci.}, title = {Strategic mobility engineering in 2D semiconductor-based FETs for enhanced electronic devices}, volume = {12}, year = {2025}, }
• (2025). Rapid charge extraction via hole and electron transfer layers on Cu2O photocathode for stable and efficient photoelectrochemical water reduction. ADVS, 12(40), e09030. (www)

  @article{ , abstract = {Photoelectrochemical (PEC) water reduction offers a promising method for generating “green” hydrogen. The hydrogen evolution reaction (HER) at the photocathode is significantly constrained, primarily because of the rapid recombination of photogenerated electron–hole pairs and the high energy barrier encountered during the water splitting step. Here, a unique “sandwich” structure FeOOH/Cu 2 O/ZnO composite photocathode is fabricated by hydrothermal and electrodeposition methods. Photogenerated holes are extracted and transferred from the Cu 2 O to FTO substrates more easily via the introduction of FeOOH as a hole storage/transport layer. Charge recombination is hindered by the ZnO layer, which functions an electron transfer agent. Hence, the FeOOH/Cu 2 O/ZnO photocathode presents remarkable PEC water reduction capability. The maximum photocurrent density of the FeOOH/Cu 2 O/ZnO photocathode (−2.54 mA·cm −2 ) is 12.7 times greater than that of pristine Cu 2 O (−0.2 mA·cm −2 ) at 0 V RHE . The IPCE of FeOOH/Cu 2 O/ZnO reaches 33.7% (455 nm), which is 8.1 times higher than the value of bare Cu 2 O (4.18%). The theoretical calculations reveal that energy barrier of HER on FeOOH/Cu 2 O/ZnO photocathode is dramatically reduced, greatly improving the catalytic activity for HER. This study highlights the crucial functions of solar PEC conversion and offers comprehensive insights into interfacial charge transfer in designing efficient photocathode materials.}, archive = {J_ADVS}, author = {Shuangshuang Huai and Xiang Li and Ping Li and Shijian Zhang and Xiuxiu Huang and Wenbin Ruan and Jianli Chen and Zhi Tang and Xiaoli Zhao and Hewen Liu and Xiufang Wang}, doi = {10.1002/advs.202509030}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e09030}, shortjournal = {Adv. Sci.}, title = {Rapid charge extraction via hole and electron transfer layers on Cu2O photocathode for stable and efficient photoelectrochemical water reduction}, volume = {12}, year = {2025}, }
• (2025). Shape memory graphene with ultrahigh specific energy dissipation. ADVS, 12(40), e08910. (www)

  @article{ , abstract = {The properties of architected materials, such as origami, kirigami, and lattice materials, are determined by the intrinsic properties of the base material and the designed architecture. It is shown that van der Waals interaction between the elements of the architecture is critical for the mechanical properties of nano-architected triangular graphene. Molecular dynamics simulations demonstrate that interplay between the flexibility and high Young's modulus of graphene, the designed architecture, and the van der Waals interaction between graphene ligaments results in a shape memory effect with a specific energy dissipation of more than 25 times that of the well-known shape memory alloy NiTi. A shape memory effect with ultrahigh specific energy dissipation is ideal for vibration control and reusable impact absorption devices.}, archive = {J_ADVS}, author = {Duc Tam Ho and Udo Schwingenschlögl}, doi = {10.1002/advs.202508910}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08910}, shortjournal = {Adv. Sci.}, title = {Shape memory graphene with ultrahigh specific energy dissipation}, volume = {12}, year = {2025}, }
• (2025). Achieving highly robust polymeric microspheres with efficient and full-color organic afterglow for 3D printing and anti-counterfeiting. ADVS, 12(40), e08888. (www)

  @article{ , abstract = {In this work, highly robust polymer-based luminescent microspheres with efficient and full-color organic afterglow are developed for the first time. N -phenylnaphthalen-1-amine, N -phenylphenanthren-9-amine, and N -phenyltriphenylen-2-amine are employed as guest luminogens and embedded into melamine-formaldehyde polymer matrices with compact and permanent three-dimensional (3D) covalent networks via host-guest doping and emulsion polymerization. The resulting polymeric microspheres, with a diameter of ≈2 µm, show blue to yellow-green organic afterglow at room temperature. Excitingly, their phosphorescence quantum yields and lifetimes are up to 18.0% and 1.39 s, respectively, representing a breakthrough in comprehensive organic afterglow performance for polymer-based luminescent microspheres. Meanwhile, dual-mode organic afterglow and persistent red fluorescence with a lifetime of 0.24 s and a quantum yield of 22.2% are also achieved from the microspheres by simply replacing the guest luminogen and the phosphorescence resonance energy transfer approach, respectively. More importantly, the polymer-based organic afterglow microspheres exhibit outstanding resistance to water and organic solvents. Inspired by the efficient and highly robust organic afterglow, potential applications of the polymeric microspheres are demonstrated in stretchable elastomers, information anti-counterfeiting, 3D printing, and explosive detection. This work provides a universal strategy for developing polymeric microspheres with efficient, robust, and colorful organic afterglow.}, archive = {J_ADVS}, author = {Pengtao Hu and Yu Lang and Jiahui Sun and Lilin Wang and Zhiling Liang and Zhan Yang and Chunping Ma and Miao Luo and Peiwei Lin and Jiaqing Li and Chunxiong Zheng and Guang Shi and Zhenguo Chi and Bingjia Xu}, doi = {10.1002/advs.202508888}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08888}, shortjournal = {Adv. Sci.}, title = {Achieving highly robust polymeric microspheres with efficient and full-color organic afterglow for 3D printing and anti-counterfeiting}, volume = {12}, year = {2025}, }
• (2025). Organic electrochemical transistors monolithically integrated with precise micro-dispensing enable high-performance biosignals amplification. ADVS, 12(40), e08872. (www)

  @article{ , abstract = {Organic electrochemical transistors (OECTs) are key components in advanced bioelectronics, wearable devices, and neuromorphic biointerfaces. However, to fully unlock their potential and facilitate widespread adoption, the development of high-performance OECTs and their seamless integration into circuits is essential, yet still limited. In this work, the monolithic integration of OECTs and OECT-based amplifiers, fabricated entirely on flexible substrates using high-resolution micro-dispensing, is reported. This additive method enables precise deposition of conductors, semiconductors, insulators, and electrolytes across a wide viscosity range (10 –10 5 cP) with micrometer-scale resolution and femtoliter-volume control. The resulting transistors achieve a record intrinsic gain of 330 V/V and form the basis for fully printed amplifier circuits with a maximum voltage gain of 77.5 and a supply-normalized gain of 193.7 V −1 . These amplifiers demonstrate a gain-bandwidth product of 1 MHz – the highest reported for fully printed OECTs – and enable real-time acquisition and amplification of electrooculography (EOG) signals with minimal distortion. This work establishes micro-dispensing as a scalable and reliable method for manufacturing high-performance printed bioelectronic circuits, bridging the gap between low-cost fabrication and the performance requirements of next-generation bioelectronics.}, archive = {J_ADVS}, author = {Roberto Granelli and Virginia M. Demartis and Giulia Frusconi and Zsolt M. Kovács-Vajna and Fabrizio Torricelli}, doi = {10.1002/advs.202508872}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08872}, shortjournal = {Adv. Sci.}, title = {Organic electrochemical transistors monolithically integrated with precise micro-dispensing enable high-performance biosignals amplification}, volume = {12}, year = {2025}, }
• (2025). Hsa_circ_0026782 acts as a “Molecular break” of CREB1-mediated transcription by promoting its phosphorylation at ser142 that prevents keloid progression. ADVS, 12(40), e08647. (www)

  @article{ , abstract = {Keloids are a form of excessive fibrosis disease characterized by tumor-like features, which are prone to recurrence. Circular RNAs play a role in various diseases, but its roles in keloids remain unclear. In this study, using high-throughput RNA sequencing to compare keloids with normal scars, a novel circRNA, hsa_circ_0026782 is identified, whose expression is downregulated in keloids. The hsa_circ_0026782 inhibits the proliferation, migration, invasion, and apoptosis of primary human keloid fibroblasts, blocks the cell cycle in the S phase in vitro, and prevents keloid progression in vivo. Mechanistically, 1–90 nucleotides of hsa_circ_0026782 directly bind to the transcription factor CREB1. This interaction increases the exposure of the basic leucine zipper domain of CREB1 to enhance its dimerization. In addition, this interaction also promotes CREB1 phosphorylation at serine residue 142, inhibits the binding of CREB1 to the promoters or enhancers of its downstream target genes, and ultimately alters the transactivation of CREB1. The findings unveil that the hsa_circ_0026782/CREB1 axis acts as a transcriptional spatiotemporal “molecular break” in the formation of keloids, providing a new target for the therapy of keloids.}, archive = {J_ADVS}, author = {Xin-Cao Zhong and Chun-Ye Chen and Zi-Xuan Feng and Yong Wang and Tao Zhang and Ze-Ming Zhuang and Zhang-Rui Wu and Yong-Zhong Du and Jun Chen and Xiao-Ying Lin and Wei-Qiang Tan}, doi = {10.1002/advs.202508647}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08647}, shortjournal = {Adv. Sci.}, title = {Hsa_circ_0026782 acts as a “Molecular break” of CREB1-mediated transcription by promoting its phosphorylation at ser142 that prevents keloid progression}, volume = {12}, year = {2025}, }
• (2025). Establishment of “Structure-efficiency” relationship in ultra-high purity metal systems: Multi-scale analysis of tellurium as a prototype. ADVS, 12(40), e08531. (www)

  @article{ , abstract = {As critical strategic materials, ultra-high-purity scattered metals play roles across cutting-edge technological domains. Significant challenges remain in investigating the spatial location and chemical environment of impurities in high-purity systems due to the limitations of conventional thermodynamic techniques and characterization resolution, hindering the improvement of purification efficiency. In this study, using tellurium as a model, a cross-scale methodology is developed to elucidate the correlation between structural evolution and impurity separation efficiency. Experimental results show that increasing fusion rates induced transitions in growth orientation from (104) to (012) with reduced impurity content, accompanied by the morphological evolution from irregular to columnar grains. Phase-field simulations reveal that the interface structure and grain competition drove the orientation transitions from (001) to (012). Density functional theory calculations confirmed the thermodynamic superiority of the (012) orientation, demonstrating weaker impurity adsorption at liquid / (012) interfaces versus liquid / (104). Based on these mechanisms, the Bridgman method is employed to enhance the preferred orientation in the tellurium crystal, significantly improving its purification efficiency. This multi-scale investigation establishes a comprehensive framework for understanding the “structure-efficiency” relationship in ultra-high-purity metals, providing theoretical guidance for the development of targeted deep purification technologies.}, archive = {J_ADVS}, author = {Shuai Guo and Xianglei Dong and Lin Zheng and Ming Gao and Guoqin Cao and Ping Peng and Jilin He and Junhua Hu}, doi = {10.1002/advs.202508531}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08531}, shortjournal = {Adv. Sci.}, title = {Establishment of “Structure-efficiency” relationship in ultra-high purity metal systems: Multi-scale analysis of tellurium as a prototype}, volume = {12}, year = {2025}, }
• (2025). SNORA58 facilitates radioresistance via suppressing JNK1-mediated ferroptosis in esophageal squamous cell carcinoma. ADVS, 12(40), e08515. (www)

  @article{ , abstract = {Radioresistance represents a substantial challenge in cancer treatment, particularly in esophageal squamous cell carcinoma (ESCC), where the underlying molecular mechanisms remain incompletely understood. Small nucleolar RNAs (snoRNAs), primarily located in the nucleolus, are noncoding RNAs whose roles in ESCC radiotherapy are unclear. In this study, an upregulated snoRNA, SNORA58 is identified in ESCC via a snoRNA PCR array. Furthermore, based on multicenter data, SNORA58 is established as a promising biomarker for predicting response to neoadjuvant chemoradiotherapy (nCRT). Patients with high SNORA58 expression levels presented a lower likelihood of achieving a complete response to nCRT and poorer clinical outcomes. Functionally, SNORA58 enhances cancer cell resistance to radiotherapy without affecting chemotherapeutic sensitivity. Mechanistically, SNORA58 stabilizes CTCF by inhibiting its ubiquitin-mediated degradation, leading to JNK1 downregulation and subsequent inactivation of the JNK signaling pathway; this disrupts intracellular iron homeostasis, thereby alleviating radiotherapy-induced ferroptosis. Notably, the administration of a JNK signaling activator significantly restored the radiosensitivity of high-SNORA58 ESCC cells both in vitro and in vivo. These findings elucidate the first demonstration of SNORA58 as a critical regulator of radioresistance in ESCC and reveal a novel link between snoRNAs and ferroptosis in this specific context, suggesting potential therapeutic strategies for managing ESCC.}, archive = {J_ADVS}, author = {Yinli Zheng and Fangyi Liu and Yuhua Huang and Yanfen Feng and Xia Yang and Jinjun Wu and Xin Yang and Xuanhao Lin and Lives Jiang and Tingting Zeng and Yan Li and Xinyuan Guan and Yuanyuan Wang and Chunyan Chen and Jingping Yun}, doi = {10.1002/advs.202508515}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08515}, shortjournal = {Adv. Sci.}, title = {SNORA58 facilitates radioresistance via suppressing JNK1-mediated ferroptosis in esophageal squamous cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Sacrificial template-derived CoMo-LDH gas diffusion electrode for anion exchange membrane water electrolysis. ADVS, 12(40), e08370. (www)

  @article{ , abstract = {Anion exchange membrane water electrolysis (AEMWE) offers a cost-effective and efficient platform for hydrogen production by enabling the use of non-platinum group metal (non-PGM) electrode materials. However, the sluggish kinetics of the oxygen evolution reaction (OER) remains a key challenge. In this study, a CoMo-LDH OER electrode for AEMWE is developed via a sacrificial template strategy. The high valence state of Mo promotes oxygen vacancy formation, enhancing OER performance. Electrochemical reconstruction also induces a phase transition into active (oxy)hydroxide species during OER. Density functional theory (DFT) calculations show that the weak OH − adsorption energy of CoMo-LDH lowers the energy barrier for OH − deprotonation, improving catalytic activity. The CoMo-LDH electrode demonstrates superior performance in AEMWE compared to the PGM-based IrO 2 electrode. This study highlights the potential of sacrificial template-based electrodes for high-performance AEMWE.}, archive = {J_ADVS}, author = {Sung Jun Lee and Youngtae Park and Seung Hun Lee and Seo Hyun Park and In Tae Kim and Youngji Kim and Baek San Soh and Geon Hwee Kim and Jooyoung Lee and Seunghwa Lee and Kihyun Shin and Yoo Sei Park}, doi = {10.1002/advs.202508370}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08370}, shortjournal = {Adv. Sci.}, title = {Sacrificial template-derived CoMo-LDH gas diffusion electrode for anion exchange membrane water electrolysis}, volume = {12}, year = {2025}, }
• (2025). Solvent-rich pre-coagulation bath for tunable liquid-state fusion enables robust two-step polymer embedded printing. ADVS, 12(40), e08335. (www)

  @article{ , abstract = {Effective interlayer fusion is a critical step enabling a 3D printing process. For engineering polymer printing, interlayer fusion is usually either heat-enabled or binder-based, which may introduce thermal residual stress, warpage, and undesirable impurities. To overcome such challenges, a two-step immersion phase separation (IPS)-based room-temperature polymer fusion and solidification approach for self-supported engineering polymer printing, termed IPS-embedded 3D printing (IPS-E3DP) is introduced. IPS-E3DP is implemented by first depositing polymer inks in a solvent-rich yield-stress pre-coagulation support bath to have an intermediate green part and then immersing the intermediate green part in a non-solvent coagulation bath for complete solidification. During the first critical step, dissolved polymer ink holds its deposited shape and fuses with a previously deposited polymeric feature in the pre-coagulation support bath. Specifically, it is the high-concentration solvent bath (usually 80% or higher) that enables tunable liquid-state fusion of polymers when the deposited polymer solidifies, and it is the yield-stress support bath that prevents the deposited polymer ink from spreading and deformation during fusion. IPS-E3DP enables the self-supported room-temperature high-fidelity printing of a wide range of engineering polymers, blends, and composites with superior geometric complexity. The process can be tailored as a polymer binder-based printing approach for versatile material printing.}, archive = {J_ADVS}, author = {Kaidong Song and Qian Wu and Ashley M. Compaan and Junting Shen and Chuanshen Zhou and Mingwei Chen and Marc Sole-Gras and John-Thomas T. Robinson and Bing Ren and Huayong Yang and Yong Huang and Jun Yin}, doi = {10.1002/advs.202508335}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08335}, shortjournal = {Adv. Sci.}, title = {Solvent-rich pre-coagulation bath for tunable liquid-state fusion enables robust two-step polymer embedded printing}, volume = {12}, year = {2025}, }
• (2025). Multifunctional and flexible phase change composites for dual-mode thermal management of lithium-ion batteries. ADVS, 12(40), e08314. (www)

  @article{ , abstract = {Phase change materials (PCMs) are highly renowned for their substantial latent heat capacity, enabling efficient thermal management in applications such as buildings, wearable devices, and lithium-ion batteries (LIBs). However, conventional PCMs suffer from mechanical rigidity, leakage, and low thermal conductivity. In this study, multifunctional, flexible, and leakage-proof phase change composites (PCCs) are developed to overcome these limitations and enable dual-mode thermal regulation for all-climate LIBs. The PCCs provide Joule heating (22.5 °C min −1 ) under subzero conditions to prevent lithium plating and restore capacity. Simultaneously, they deliver passive cooling to optimise the operating temperature of LIBs, acrosspower output scenarios (2C and 3C). The performance is further supported and validated through COMSOL simulations, which shed light on PCCs’ phase change behaviour, the working temperature, and the heat distribution of LIBs. The integration of carbon nanofillers significantly enhances thermal conductivity by 240% while maintaining structural integrity. Additionally, the PCCs can function as overheating switches and temperature sensors (7.2%/°C at 40–45 °C) through a positive temperature coefficient (PTC) effect. Featuring low thickness (≈550 µm), leakage proof, and mechanical flexibility, these PCCs present a promising solution for advanced thermal management for safer and more efficient LIB operation.}, archive = {J_ADVS}, author = {Lichang Lu and Haosong He and Hongxu Guo and Ignacio Martin-Fabiani and Emiliano Bilotti and Han Zhang and Ashley Fly and Yi Liu}, doi = {10.1002/advs.202508314}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08314}, shortjournal = {Adv. Sci.}, title = {Multifunctional and flexible phase change composites for dual-mode thermal management of lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Shielding si armed with CoSi2 nanoplates and dual-carbon shells: 3D porous microspheres as high-performance anodes for li-ion batteries. ADVS, 12(40), e08213. (www)

  @article{ , abstract = {In this study, a novel multi-core–dual-shell strategy is employed to synthesize 3D porous microspheres. These microspheres consist of Si armed with CoSi 2 nanoplates multi-cores encapsulated within dual protective shells of metallic-Co nanocrystals embedded nitrogen-doped graphitic carbon (NGC) and polydopamine-derived carbon (PDA-C), denoted as Si@CoSi 2 -Co/NGC@PDA-C, through a multistep synthesis process involving facile spray pyrolysis and post-heat-treatment. The Si as an active material is surrounded by an inactive buffer material of CoSi 2 with intrinsic low bulk resistivity and high chemical stability, enhancing the electrical interconnectivity and mechanical integrity of the nanostructure. The metallic-Co embedded porous NGC shell facilitates rapid electron transfer by providing primary transport pathways due to its high conductivity, while improving structural robustness by partially restraining the volume expansion of Si. Finally, an additional PDA-derived C protective shell provides secondary transport pathways while mitigating volume expansion, preventing complete detachment from the current collector or pulverization. Correspondingly, the Si@CoSi 2 -Co/NGC@PDA-C anode exhibits considerable rate capability (up to 10 A g −1 ) and remarkable cycling stability (88% capacity retention after 600 cycles; average capacity loss of 0.02% per cycle at 1.0 A g −1 ). Moreover, full-cells paired with a Li(Ni 0.8 Co 0.1 Mn 0.1 )O 2 cathode are evaluated to confirm the practical viability of the nanostructures.}, archive = {J_ADVS}, author = {Jae Seob Lee and Hyun Seon Ahn and Jung Yeon Kim and Rakesh Saroha and Beom Su Jo and Ji Hun Baek and Yun Chan Kang and Gi Dae Park and Dae Soo Jung and Dong-Won Kang and Chungyeon Cho and Jung Sang Cho}, doi = {10.1002/advs.202508213}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08213}, shortjournal = {Adv. Sci.}, title = {Shielding si armed with CoSi2 nanoplates and dual-carbon shells: 3D porous microspheres as high-performance anodes for li-ion batteries}, volume = {12}, year = {2025}, }
• (2025). An “s-electron” donor band driven metallic ferromagnetism in co-doped ZnO films. ADVS, 12(40), e08148. (www)

  @article{ , abstract = {Achieving room-temperature ferromagnetism (RTFM) in diluted magnetic semiconductors (DMSs) has been a long-standing challenge, with doping transition metals (TM) into oxide semiconductors being one of the most common approaches. However, the underlying physical mechanisms remain poorly understood, particularly for Co-doped ZnO (Co:ZnO) films, which exhibit high Curie temperatures (T c ) above 300 K. A promising mechanism proposed for high-T c ferromagnetism is the donor impurity band exchange model, in which donor electrons mediate the coupling between TM spins. Despite its theoretical significance, the nature of the donor band electrons has yet to be experimentally identified. In this work, we use polarization-dependent, bulk-sensitive hard x-ray photoemission spectroscopy (HAXPES) to investigate Co-doped ZnO epitaxial films. Our results reveal the presence of a weak electron donor band, crossing the Fermi level, and from a polarization dependence analysis, it is unambiguously identify it as having “ s- character.” This finding offers new insight into the ferromagnetic mechanism in Co-doped ZnO, where Zn 1+ 4 s 1 states mediate the ferromagnetism, contributing to metallic-like transport and Co 2+ spin ordering. These results not only elucidate the complementary role of dopant-host electronic states but also open avenues for designing novel room-temperature magnetic semiconductors, particularly in the context of 2D DMSs.}, archive = {J_ADVS}, author = {Pei-Yu Chuang and Jung-Chun-Andrew Huang and Ashish Atma Chainani and Hua-Shu Hsu and Yen-Fa Liao and Chang-Yi Sung and Chih-Hua Liu and Chien-Yu Liao and Chi-Hsuan Lee and Ku-Ding Tsuei}, doi = {10.1002/advs.202508148}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08148}, shortjournal = {Adv. Sci.}, title = {An “s-electron” donor band driven metallic ferromagnetism in co-doped ZnO films}, volume = {12}, year = {2025}, }
• (2025). Phase-space generalized brillouin zone for spatially inhomogeneous non-hermitian systems. ADVS, 12(40), e08047. (www)

  @article{ , abstract = {The generalized Brillouin zone (GBZ) is highly successful in characterizing the topology and band structure of non-Hermitian systems. However, its applicability ischallenged in spatially inhomogeneous settings, where the non-locality of non-Hermitian pumping competes with Wannier-Stark localization and quantum interference, potentially leading to highly non-exponential state accumulation. To transcend this major conceptual bottleneck, a general phase-space GBZ formalism is developed that encodes non-Bloch deformations in both position and momentum space, such as to accurately represent spatially inhomogeneous non-Hermitian pumping. A key new phenomenon is the bifurcation of the phase-space GBZ branches, which allows certain eigenstates to jump abruptly between different GBZ solutions at various points in real space, such as to accommodate pockets of inhomogeneity. The freedom in the jump locations opens up an emergent degree of freedom that protects the stability of real spectra and, more impressively, the robustness of a new class of topological zero modes unique to GBZ bifurcation. The response from these novel spectral and GBZ singularities can be readily demonstrated in mature metamaterial platforms such as photonic crystals or circuit arrays. The framework directly generalizes to more complicated unit cells and further hoppings, opening up a vast new arena for exploring unconventional spectral and topological transitions, as well as GBZ fragmentation in spatially inhomogeneous non-Hermitian settings.}, archive = {J_ADVS}, author = {Qingya Li and Hui Jiang and Ching Hua Lee}, doi = {10.1002/advs.202508047}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e08047}, shortjournal = {Adv. Sci.}, title = {Phase-space generalized brillouin zone for spatially inhomogeneous non-hermitian systems}, volume = {12}, year = {2025}, }
• (2025). Decoy extracellular vesicles overcome triple-negative breast cancer heterogeneity via membrane-cytoplasm-mitochondria cascade targeting. ADVS, 12(40), e07975. (www)

  @article{ , abstract = {Triple-negative breast cancer (TNBC) exhibits multilevel heterogeneity, including differences in stemness, immune checkpoint (IC) upregulation, and metabolic plasticity, which has resulted in a lack, of comprehensive treatment strategies. Extracellular vesicles (EVs) from exhausted T cells contain high levels of ICs, which allow them to target and block multiple IC ligands in tumor cells, including cancer stem cells (CSCs). TEAD4 is identified as a pivotal gene facilitating CSC growth and immune escape. Consequently, a novel EV delivery system (siT/MOF@EVs), which targets the tumor cell membrane–cytoplasm–mitochondria cascade, is engineered to codeliver TEAD4-siRNA (siTEAD4) and a mitochondria-targeting metal–organic framework (T/MOF) to overcome tumor heterogeneity. Extracellularly, EVs act as “decoys” by facilitating the binding of IC ligands to target tumor cells, particularly CSCs, and blocking multiple ICs. Within the cytoplasm, the siTEAD4 adsorbed on the T/MOF surface is released, inhibiting CSCs and overcoming immunotherapy resistance. In mitochondria, cascade catalysis by nanozymes that bind monoatomic Pd and Mn 2+ triggers an oxidative burst. Additionally, siTEAD4 and T/MOF synergistically block aerobic glycolysis and oxidative phosphorylation and induce immunogenic tumor cell death. siT/MOF@EVs overcome TNBC heterogeneity, inhibit tumor growth and metastasis, and induce protective immune memory in an orthotopic TNBC model without systemic toxicity. Significant therapeutic effects are also observed in a patient-derived organoid xenograft (PDOX) model.}, archive = {J_ADVS}, author = {Chuanrong Chen and Ming Shen and Xiaofeng Wan and Lili Sheng and Na Hao and Man Li and Menglin Xu and Yang He and Jiali Zhang}, doi = {10.1002/advs.202507975}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07975}, shortjournal = {Adv. Sci.}, title = {Decoy extracellular vesicles overcome triple-negative breast cancer heterogeneity via membrane-cytoplasm-mitochondria cascade targeting}, volume = {12}, year = {2025}, }
• (2025). POSTN-mediated interplay of m1 polarized macrophage with tendon-derived stem cells to drive traumatic heterotopic ossification formation through PTK7/ATK signaling?. ADVS, 12(40), e07951. (www)

  @article{ , abstract = {Tendinous heterotopic ossification can cause pain and restricted joint mobility in affected areas, and it is a common and severe complication following tendon injuries. This condition significantly reduces the postoperative quality of life of patients, and its incidence is increasing year by year. Due to the unclear pathogenesis, there are currently no effective treatment methods. Although recent studies suggest that macrophages affect the process of traumatic heterotopic ossification (HO) in mice, their role in HO still requires further clarification. Here, it is disclosed that the formation of trauma-induced HO is accompanied by the polarization of macrophages toward the M1 phenotype. Additionally, secretion containing periostin (POSTN) that is secreted by M1 macrophages reduces fatty acid β – oxidation in tendon-derived stem cells (TDSCs) and facilitates the formation of heterotopic bone. Mechanistically, M1 macrophages release POSTN during the HO process, which directly binds to PTK7 in TDSCs,  thereby increasing AKT phosphorylation at the S124 site and initiating osteogenic differentiation. This study demonstrates the role of M1 macrophages and their secreted POSTN in traumatic heterotopic ossification, highlighting the potential of POSTN as a therapeutic target for HO.}, archive = {J_ADVS}, author = {Hang Liu and Xinyue Li and Mengyi Li and Ziyang Sun and Xu Wang and Juehong Li and Binbin Xu and Qian Chen and Cunyi Fan and Hongjiang Ruan}, doi = {10.1002/advs.202507951}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07951}, shortjournal = {Adv. Sci.}, title = {POSTN-mediated interplay of m1 polarized macrophage with tendon-derived stem cells to drive traumatic heterotopic ossification formation through PTK7/ATK signaling?}, volume = {12}, year = {2025}, }
• (2025). Alternative models for anticancer drug discovery from natural products using binary tumor-microenvironment-on-a-chip. ADVS, 12(40), e07944. (www)

  @article{ , abstract = {The efficacy evaluation of anticancer drugs derived from natural products has traditionally relied on animal models, highlighting the need for more efficient preclinical assessment platforms. In this study, a binary tumor-microenvironment-on-a-chip (T-MOC) system is introduced to assess the therapeutic potential of illudin S and roridin E, two cytotoxic compounds derived from Omphalotus japonicus and Podostroma cornu-damae , respectively. The binary T-MOC model integrates independently developed vascular and invasive ductal carcinoma compartments, effectively mimicking in vivo drug delivery barriers and physiological dynamics. Using this model, illudin S demonstrates strong anticancer effects but exhibits high toxicity, particularly in the lung and liver, indicating a narrow therapeutic window. Roridin E demonstrates potent activity at low concentrations but exhibits high toxicity, especially in the liver and skin. Additionally, morphological analysis is performed to predict drug delivery and distribution characteristics, revealing anisotropic remission and the influence of microenvironmental factors on drug response. This study underscores the potential of the binary T-MOC system as an alternative platform for anticancer drug evaluation, enabling efficient preclinical validation while reducing reliance on animal models.}, archive = {J_ADVS}, author = {Youngwon Kim and Si Hyeon Chae and Dahae Lee and Bum Soo Lee and Jiseok Lim and Hyo-Il Jung and Ki Hyun Kim and Bongseop Kwak}, doi = {10.1002/advs.202507944}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07944}, shortjournal = {Adv. Sci.}, title = {Alternative models for anticancer drug discovery from natural products using binary tumor-microenvironment-on-a-chip}, volume = {12}, year = {2025}, }
• (2025). Programmable and reversible 3D-to-3D shape transformation: Hierarchical multimodal morphing based on liquid crystal elastomers. ADVS, 12(40), e07922. (www)

  @article{ , abstract = {Achieving programmable morphing in 3D-to-3D shapes of soft actuators based on liquid crystal elastomer (LCE), particularly those with multimodal transformations and non-zero Gaussian curvature, remains a significant challenge. Here, a facile strategy is presented to create 3D LCE-elastomer (LCE-Ela) bilayer structures capable of customizable and programmable 3D-to-3D shape transformations, generating reversible and multimodal morphologies with nonzero Gaussian curvature. By combining two types of mismatch strains—pre-stretch and thermal strains—in LCE-Ela bilayer, the approach enables hierarchical multimodal transformations: starting from a 2D initial configuration, programmable transformations enable the formation of complex 3D structures, which can subsequently transition into other 3D shapes following predefined programs, with each step of the hierarchical process allowing multimodal deformations to generate diverse structural morphologies. Experimental and computational demonstrations include over 30 diverse 3D LCE-Ela configurations, the majority of which exhibit nonzero Gaussian curvature. Moreover, biomimetic LCE-Ela structures—including a chameleon, butterfly, spider, and leaf—demonstrate vivid deformation and discoloration, showcasing their potential for applications such as information encryption, camouflage, and adaptive devices. This work provides a facile approach to generate customizable 3D-to-3D transformations with complex geometries, broadening the application scope of LCE-based technologies in 3D soft actuators.}, archive = {J_ADVS}, author = {Jiayu Tian and Chuanqian Shi and Guohua Nie and Chenzhe Li and Ying Zhao}, doi = {10.1002/advs.202507922}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07922}, shortjournal = {Adv. Sci.}, title = {Programmable and reversible 3D-to-3D shape transformation: Hierarchical multimodal morphing based on liquid crystal elastomers}, volume = {12}, year = {2025}, }
• (2025). Flexible memory application of nanoscale Ti–Ge–Te thin film as information storage medium with excellent thermal stability, low resistance drift and superior bending characteristic. ADVS, 12(40), e07859. (www)

  @article{ , abstract = {The flexible Ti–Ge–Te phase change material was proposed and fabricated by magnetron cosputtering method. The impact of titanium dopant and mechanical bending on the thermal stability, electrical resistance, surface morphology, microstructure, and crystallization mechanism of GeTe thin film are investigated systematically. With the incorporation of appropriate titanium dopant, the crystallization process and grain size of GeTe material can be hindered. Meanwhile, the thermal stability, surface morphology, and crystal structure have not been changed obviously when the bending times reaching 10 6 , demonstrating the distinguished mechanical bending performance. The phase change memory devices with Ti-doped GeTe were prepared based on flexible polyimide substrates, and the electronical properties are evaluated. The consequences show that the phase change memory can still exhibit the negative resistance phenomenon and complete the erase/write operation after bending 10 6 cycles. The density functional theory calculations of band structure illustrate that titanium dopant can convert the indirect band gap of GeTe material to the direct type. The formation energy and charge density difference indicate the massive electron cloud agglomerate between the Ti and Te atoms, deducing that the foreign Ti may occupy the position of Ge and form the covalent bonds with Te.}, archive = {J_ADVS}, author = {Han Gu and Weihua Wu and Xiaochen Zhou and Pei Zhang and Bowen Fu and Jiwei Zhai and Sannian Song and Zhitang Song}, doi = {10.1002/advs.202507859}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07859}, shortjournal = {Adv. Sci.}, title = {Flexible memory application of nanoscale Ti–Ge–Te thin film as information storage medium with excellent thermal stability, low resistance drift and superior bending characteristic}, volume = {12}, year = {2025}, }
• (2025). Dual-wavelength responsive hydrogel glue with visible-light bonding and UV-triggered debonding via ortho-nitrobenzyl cleavage. ADVS, 12(40), e07809. (www)

  @article{ , abstract = {Removable adhesives with controllable bonding and debonding capabilities are essential for biomedical devices, temporary fixation, and recyclable materials. Here, a dual-wavelength hydrogel glue is presented that integrates visible-light polymerization (470 nm) for strong adhesion and UV-induced degradation (365 nm) for rapid debonding. The system leverages camphorquinone as a visible-light photoinitiator and ortho-nitrobenzyl poly(ethylene glycol) dimethacrylate (ONB-PEGDMA) as a UV-cleavable crosslinker, ensuring independent control over adhesion and detachment with orthogonal polymerization and degradation. The degradation rate of ONB-PEGDMA increases proportionally with light intensity, providing precise control over cleavage kinetics, with first-order rate constants of 0.155, 0.278, and 0.669 min −1 for 20, 50, and 100 mW cm − 2 , respectively. The hydrogel exhibits strong adhesion (≈200 kPa) and undergoes a fourfold reduction in adhesion strength within 90 s of 365 nm irradiation at 100 mW cm − 2 under a constant tensile load of 10 N, enabling efficient removal. Rheological analysis confirms a significant decrease in storage modulus and crosslinking density after UV exposure, leading to network softening and structural failure. This work pioneers a phototunable hydrogel glue that bridges photopolymerization and photodegradation, offering a promising platform for next-generation adhesives with precise spatiotemporal control and with easy application, good bonding, and rapid UV-triggered debonding.}, archive = {J_ADVS}, author = {Huaming Wang and Xianyan Shen and Changling Du and Xian-You Liu and Anyu Yang and Yanni Cao and Aijie Han and Qihan Liu and Jennifer Laaser and Wei Zhang}, doi = {10.1002/advs.202507809}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07809}, shortjournal = {Adv. Sci.}, title = {Dual-wavelength responsive hydrogel glue with visible-light bonding and UV-triggered debonding via ortho-nitrobenzyl cleavage}, volume = {12}, year = {2025}, }
• (2025). Three-step pulse strategy enhances ultradilute nitrate-to-ammonia conversion via microenvironment and mass transfer control. ADVS, 12(40), e07720. (www)

  @article{ , abstract = {Nitrate pollution in wastewater, primarily originating from industrial, agricultural, and domestic sources, typically occurs at concentrations of 10 m m or lower. Although the nitrate reduction reaction (NO 3 RR) has been one of the most intensively researched fields with a mature FE (Faraday efficiency) over 90% and a milligram-level yield of ammonia, it remains difficult to deal with low-nitrate environments, such as municipal wastewater. In this study, a three-step pulsed strategy is presented that attains nearly 100% ammonia FE from an ultralow 10 m m nitrate concentration electrolyte, representing a threefold enhancement over the conventional constant potentiostatic approach. Through operando characterizations, density functional theory calculations and COMSOL simulations, the mechanism is elucidated by which various potential biases concurrently modulate NO 3 RR intermediates, thereby enhancing reaction kinetics and effectively suppressing the competing hydrogen evolution reaction. Furthermore, practical application in a flow cell, along with techno-economic analysis, highlights the technological and economic feasibility of converting nitrate into valuable ammonia directly from wastewater without preconcentration. The research advances the understanding of pulse-driven strategies and the modulation of ionic microenvironments in electrochemical processes, paving the way for practical and environmentally friendly wastewater treatment and ammonia synthesis.}, archive = {J_ADVS}, author = {Kouer Zhang and Gang Liu and Qing Wang and Xiaoyu Huo and Xiaohong Zou and Mingcong Tang and Xiao Zhang and Liang An}, doi = {10.1002/advs.202507720}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07720}, shortjournal = {Adv. Sci.}, title = {Three-step pulse strategy enhances ultradilute nitrate-to-ammonia conversion via microenvironment and mass transfer control}, volume = {12}, year = {2025}, }
• (2025). Maneuvering charge transport via insulating polymer interface for steering photoredox catalysis. ADVS, 12(40), e07670. (www)

  @article{ , abstract = {Maneuvering precise and tunable charge transportation has remained the core issue of photocatalysis, but meets with limited success owing to the ultra-fast charge recombination rate, scarcity of applicable co-catalysts, and difficulty in customizing spatially separated carrier transport pathways. Although co-catalyst engineering affords a convenient strategy to dominate spatial charge migration to the ideal active sites, the conventional co-catalyst modification strategy fails to exquisitely mediate the interface between co-catalyst and semiconductor matrix, along with tedious synthesis procedures. Herein, an insulating polyelectrolyte (NCP), poly(diallyldimethylammonium chloride), is uniformly and seamlessly coated on the transition metal chalcogenides (TMCs) substrates via a facile electrostatic self-assembly approach and strategically serves as the highly efficient catalytic active sites for stimulating multifarious photoredox catalysis, including selective organic transformation and CO 2 reduction. The crucial roles of such NCP are unambiguously unraveled via comprehensive experimental and theoretical investigations, which include increasing reactant adsorption, providing active sites, and most importantly, boosting interfacial charge transfer rate. The electron-withdrawing capability of NCP fosters the effective charge separation over TMCs, leading to the concomitantly improved and stable photocatalytic activities toward aromatic nitro compounds reduction and CO 2 -to-syngas conversion under visible light. Our work could strengthen our fundamental understanding of the generic unanticipated charge transport characteristics of insulating polymers for solar energy conversion.}, archive = {J_ADVS}, author = {Qiao-Ling Mo and Rui Xiong and Bo-Yuan Ning and Peng Su and Qing Chen and Jun-Hao Dong and Bai-Sheng Sa and Jing-ying Zheng and Yue Wu and Fang-Xing Xiao}, doi = {10.1002/advs.202507670}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07670}, shortjournal = {Adv. Sci.}, title = {Maneuvering charge transport via insulating polymer interface for steering photoredox catalysis}, volume = {12}, year = {2025}, }
• (2025). Assessing extracellular vesicle turnover in vivo using highly sensitive phosphatidylserine-binding reagents. ADVS, 12(40), e07624. (www)

  @article{ , abstract = {Extracellular vesicles (EVs) are emerging as crucial players in cell communication and hold great promise as biomarkers and therapeutic tools. However, their diversity makes it challenging to detect, classify, and utilize them effectively, which limits their clinical applicability. A key challenge is the lack of reliable markers to identify EVs consistently. In this study, a novel high-affinity phosphatidylserine (PS)-binding reagent is introduced for EV analysis. PS is known as a marker of apoptotic cells and activated platelets, but its presence on EVs is debated due to variations in lipid composition. By comparing multiple PS-binding reagents, including MFG-E8 derivatives and Annexin V, it is demonstrated that ≈90% of EVs in human and mouse blood carry PS. Using the optimized reagent, the first in vivo insights into EV turnover are provided, showing that PS+ EVs in mouse blood are rapidly cleared (≈50% within 30 min) but persist on immune cells in the spleen. This discovery increases the potential of EVs as disease biomarkers and therapeutic targets by improving EV detection and isolation as well as opening the door for standardized quantification and diagnostic monitoring.}, archive = {J_ADVS}, author = {Lavinia Flaskamp and Monica Prechtl and Annkathrin Scheck and Wenbo Hu and Christine Ried and Georg Kislinger and Mikael Simons and Anne B. Krug and Jan Kranich and Thomas Brocker}, doi = {10.1002/advs.202507624}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07624}, shortjournal = {Adv. Sci.}, title = {Assessing extracellular vesicle turnover in vivo using highly sensitive phosphatidylserine-binding reagents}, volume = {12}, year = {2025}, }
• (2025). Reconfigurable In–S coordination in SPAN cathodes: Unlocking high sulfur utilization and fast kinetics for practical Li‒S batteries. ADVS, 12(40), e07385. (www)

  @article{ , abstract = {Sulfurized polyacrylonitrile (SPAN) has emerged as a promising cathode material for high-energy-density lithium‒sulfur (Li‒S) batteries due to its ability to confine sulfur and suppress polysulfide shuttling. However, conventional SPAN suffers from sluggish conversion kinetics and limited sulfur utilization, especially at high sulfur loadings. In this work, reconfigurable indium‒sulfur (In–S) coordination into SPAN to dynamically regulate sulfur bonding states is introduced. The non-crystalline In—S network reversibly anchors and releases sulfur during cycling, accelerating redox reactions while suppressing phase segregation. Structural analysis reveals atomically dispersed In—S coordination without crystalline inactive phases, achieving an active material content of 47.4 wt.% with only 1.18 wt.% indium addition (≈23% higher than conventional SPAN). Optimized In 5 -SPAN cathodes deliver a high specific capacity of 1048 mAh·g −1 at 0.5 A g −1 under practical conditions of high SPAN mass loading (8.7 mg cm −2 ) and lean electrolyte (E/SPAN = 4.1). This performance surpasses state-of-the-art SPAN-based cathodes under comparable lean-electrolyte and high-loading conditions. These findings illustrate a novel reconfigurable metal‒sulfur coordination strategy for next-generation Li‒S batteries with both high-energy-density and long cycle life.}, archive = {J_ADVS}, author = {Cheng Huang and Yi Gong and Qi Zhu and Miaoran Xu and Kai Yang and José V. Anguita and Wei Zhang and S. Ravi P. Silva and Yanfeng Gao and Zongtao Zhang}, doi = {10.1002/advs.202507385}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07385}, shortjournal = {Adv. Sci.}, title = {Reconfigurable In–S coordination in SPAN cathodes: Unlocking high sulfur utilization and fast kinetics for practical Li‒S batteries}, volume = {12}, year = {2025}, }
• (2025). Precision-arranged DNA origami plasmonic nanoantennas for multidimensional smart-warning of weightlessness induced bone loss. ADVS, 12(40), e07189. (www)

  @article{ , abstract = {Surface-Enhanced Raman Scattering (SERS) shows promise for monitoring health during space missions, particularly in assessing the effects of microgravity and radiation. However, traditional SERS sensors struggle with precise interfacial engineering, leading to a relatively poor assembly efficiency, and are unable to meet the practical needs of extreme spaceflight environments. To address this, it is designed and fabricated precision-arranged DNA origami plasmonic nanoantennas. By leveraging DNA origami's addressability, it is built a 3 × 4 antenna array with a controlled spacing of 21.76 nm, enhancing assembly efficiency fourfold compared to disordered systems. The ordered system enabled accurate detection of calcium ions, interleukin-6, and microRNA-214 in serum from mice exposed to microgravity and radiation, with intraclass correlation coefficients > 0.75, comparable to ELISA and qPCR. More importantly, integrating the system with a convolutional neural network enabled precise bone health prediction. This platform provides a promising tool for astronaut health monitoring.}, archive = {J_ADVS}, author = {Yufan Ling and Xuan Qin and Weijia Sun and Fan Yue and Yiwei Wang and Di Fan and Haoyuan Xu and Ruao Xie and Jiawei Zhang and Jianwei Li and Bingyan Li and Yang Yang and Yingxian Li and Houyu Wang and Guangming Zhou}, doi = {10.1002/advs.202507189}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07189}, shortjournal = {Adv. Sci.}, title = {Precision-arranged DNA origami plasmonic nanoantennas for multidimensional smart-warning of weightlessness induced bone loss}, volume = {12}, year = {2025}, }
• (2025). Real-time tracking of ASCT2-mediated glutamine uptake in living tumors with a bioorthogonal bioluminescent probe. ADVS, 12(40), e07057. (www)

  @article{ , abstract = {Glutamine addiction, as a hallmark of tumor metabolism, drives malignant progression via proliferation, survival, and metastasis. Alanine-serine-cysteine transporter 2 (ASCT2), the primary glutamine transporter, is overexpressed in tumors to meet metabolic demands, making it a promising therapeutic target. Accurately monitoring ASCT2-mediated glutamine uptake is essential for investigating tumor metabolism and developing ASCT2-targeted therapeutics. However, current methods lack specificity, require laborious sample processing, and do not support real-time measurements in living systems. To overcome these issues, BLGLN is designed, an innovative bioluminescent reporter system exploiting Staudinger ligation. BLGLN comprises two components: 1) BL568, a caged D-luciferin derivative protected with 2-diphenylphosphinobenzoic acid, and 2) AA201, an azide-modified glutamine mimetic taken up by ASCT2. Once inside, AA201 undergoes Staudinger ligation with membrane-permeable BL568, releasing D-luciferin that is converted by luciferase into a bioluminescent signal, allowing real-time tracking of ASCT2-dependent glutamine uptake in tumors. BLGLN provides simplified synthesis, eliminates complex sample preparation, and enables real-time tracking and evaluation of glutamine uptake rate in living tumors.}, archive = {J_ADVS}, author = {Bing-Jun Zhou and Ji-Lei Zhao and Fan Yin and Wen-Da Chen and Yi Sun and Ying-Ying Ren and Yi-Min Chen and Tian Xie and Chong Duan and Jian-Liang Zhou}, doi = {10.1002/advs.202507057}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07057}, shortjournal = {Adv. Sci.}, title = {Real-time tracking of ASCT2-mediated glutamine uptake in living tumors with a bioorthogonal bioluminescent probe}, volume = {12}, year = {2025}, }
• (2025). AI-driven de novo design of ultra long-acting GLP-1 receptor agonists. ADVS, 12(40), e07044. (www)

  @article{ , abstract = {Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and discovery. Here, an efficient approach that integrates deep learning-based protein design with functional screening is presented, enabling the rapid design of biotechnologically important peptides with improved stability and efficacy. 10,000 de novo glucagon-like peptide-1 receptor agonists (GLP-1RAs) are designed, 60 of these satisfied the stability, efficacy, and diversity criteria in the virtual functional screening. In vitro validations reveal a 52% success rate, and in vivo experiments demonstrate that two lead GLP-1RAs (D13 and D41) exhibit extended half-lives, approximately three times longer than that of Semaglutide. In diabetic mouse models, candidate D13 results in significantly lower blood glucose levels than Semaglutide. In the obesity mouse model, D13 induces weight loss efficacy comparable to that of Semaglutide. The AI-driven peptide design pipeline—which integrates protein design, functional screening, and experimental validation—reduces the number of iterations required to find novel peptide candidates. The entire process, from design to screening, can be completed in a single cycle within two weeks.}, archive = {J_ADVS}, author = {Ting Wei and Jiating Ma and Xiaochen Cui and Jiahui Lin and Zhuoqi Zheng and Liu Cheng and Taiying Cui and Xiaoqian Lin and Junjie Zhu and Xuyang Ran and Xiaokun Hong and Luke Johnston and Zhangsheng Yu and Haifeng Chen}, doi = {10.1002/advs.202507044}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e07044}, shortjournal = {Adv. Sci.}, title = {AI-driven de novo design of ultra long-acting GLP-1 receptor agonists}, volume = {12}, year = {2025}, }
• (2025). High conversion efficiency in intrinsic high power-density Mg2Sn-GeTe thermoelectric generator. ADVS, 12(40), e06997. (www)

  @article{ , abstract = {Thermoelectric generators (TEGs) offer a sustainable solution for thermal energy harvesting, where maximizing energy output necessitates achieving both high power density and high conversion efficiency. However, TEGs with intrinsically high power density by employing high power factor materials often face efficiency limitations due to their usually high thermal conductivity. Here, intrinsically high power density TEGs based on Mg 2 Sn-GeTe for the first time is presented, simultaneously delivering a remarkable conversion efficiency of 9% under a temperature gradient of 418 K, thereby setting a new benchmark in the field. This exceptional performance is attributed to the significant balance between the moderating carrier and phonon transport in Mg 2 Sn, enabled by a stepwise aliovalent Sb and Bi solid solution, without over-compromising its outstanding power factor. Consequently, a high thermoelectric figure of merit of 1.4 is achieved in Mg 2 Sn 0.8 (Sb 0.5 Bi 0.5 ) 0.2 . The high-performance Mg 2 Sn–GeTe TEGs introduced here represent a significant advancement in thermoelectric technology, offering an innovative and efficient solution for off-grid energy supply in waste-heat-rich environments.}, archive = {J_ADVS}, author = {Xinzhi Wu and Longquan Wang and Airan Li and Gang Wu and Zhao Hu and Fei Frank Yun and Takao Mori}, doi = {10.1002/advs.202506997}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06997}, shortjournal = {Adv. Sci.}, title = {High conversion efficiency in intrinsic high power-density Mg2Sn-GeTe thermoelectric generator}, volume = {12}, year = {2025}, }
• (2025). Comprehensive genetic map of muscle lipidome reveals novel insights into flavor variation in ruminant meat. ADVS, 12(40), e06900. (www)

  @article{ , abstract = {Ruminant meat is an important component of human diets, valued for its unique flavor and nutritional density. Lipids play a dominant role in shaping meat flavor, yet their genetic and biochemical basis remains unexplored. Here, from the analysis of 434 sheep longissimus thoracis samples, the current study presents the first comprehensive lipid map of sheep meat, including 947 lipids. A substantial proportion of these lipids exhibit moderate-to-high heritability, with 51.6% surpassing a heritability of 0.2 and 15.8% exceeding 0.45. Metabolome-based genome-wide association analysis identifies 467 significant loci affecting 233 lipids, including 110 loci exhibiting pleiotropy. Notably, the levels of monogalactosyldiacylglycerols containing oleic (C18:1) and linoleic (C18:2) acids are specifically regulated by the expression of MBOAT1 and PAQR8 genes, respectively, while 13 triglycerides and one diglyceride are co-regulated by SH2D4A . The levels of phosphatidylethanolamine PE(20:4_20:0) are regulated by VPS53 . Further examination of volatile compounds demonstrates that variations in these genetically controlled lipids significantly impact flavourant levels in cooked meat. Given the conservation of lipid profiles and genomes among ruminants, this study offers novel insights into the genetic architecture underlying meat lipid metabolism and provides a valuable resource for the targeted genetic improvement of ruminant meat flavor.}, archive = {J_ADVS}, author = {Xueying Zhang and Yuanyuan Kong and Jialei Chen and Ran Li and Zhongyu Wang and Yali Song and Tianshu Dai and Yuxin Fu and Beixiang Jiang and Jize Zeng and Shengwei Pei and Yangkai Liu and Qianjie Feng and Weiwei Fu and Zehu Yuan and Joram Mwashigadi Mwacharo and Fadi Li and Xiangpeng Yue}, doi = {10.1002/advs.202506900}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06900}, shortjournal = {Adv. Sci.}, title = {Comprehensive genetic map of muscle lipidome reveals novel insights into flavor variation in ruminant meat}, volume = {12}, year = {2025}, }
• (2025). Enhanced spectral tunability by sub-10 nm nanogaps in graphene-metal hybrid metasurfaces. ADVS, 12(40), e06898. (www)

  @article{ , abstract = {Electrically tunable graphene-metal metasurfaces have emerged as a promising platform for precise control of free-space light propagation. However, their resonance tuning range is limited by fabrication constraints, particularly by the achievable gap size between coupled antennas, which is the parameter that influences the device's performance most. In this work, this challenge is addressed by introducing a novel fabrication approach that combines traditional e-beam lithography with physical vapor deposition of an additional thin metal layer and subsequent ion milling. Incorporating an Al 2 O 3 etch-stop layer allows to overcome the ≈20 nm gap size limitation of conventional methods. Using this approach sub-10 nm gaps can be fabricated reliably and the tuning range of metasurfaces operating in the mid-infrared is increased from 0.50 to 0.77 µm, together with an enhancement in the maximum modulation depth from 45% to 59%. The better performance is attributed to stronger field enhancement in the reduced nanogap. This work is a critical step toward widely tunable mid-infrared metasurfaces, with potential applications in spatial light modulators, surface-enhanced Raman spectroscopy, and quantum photonics.}, archive = {J_ADVS}, author = {Fei Han and Zaoyang Lin and Kacper Pilarczyk and Hongwei Tang and Guy A. E. Vandenbosch and Joris Van de Vondel and Xuezhi Zheng and Niels Verellen and Ewald Janssens}, doi = {10.1002/advs.202506898}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06898}, shortjournal = {Adv. Sci.}, title = {Enhanced spectral tunability by sub-10 nm nanogaps in graphene-metal hybrid metasurfaces}, volume = {12}, year = {2025}, }
• (2025). ACSS2/AATF drives soluble FasL-mediated CD8+ t cell apoptosis in pancreatic neuroendocrine tumors. ADVS, 12(40), e06883. (www)

  @article{ , abstract = {Besides the traditional carbon sources, Acetyl coenzyme A has recently been shown to be generated from acetate in various cancers, which subsequently promotes tumor growth and immune escape. However, the mechanism of Acetyl coenzyme A availability in pancreatic neuroendocrine tumors (PNETs) remains largely unknown. Herein, the metabolic-epigenetic modification driven by acetyl coenzyme A synthase 2 (ACSS2) and its effect on the Fas/FasL system in PNETs is investigated. ACSS2 is highly expressed in PNETs and significantly correlated with patient prognosis. Mechanistically, ACSS2 activity or acetate supplementation induces histone H3/H4 hyperacetylated in PNET cells. This epigenetic modification recruits the transcription factor AATF to co-regulate FasL transcription, specifically enhancing soluble FasL secretion. Secreted FasL binds Fas receptors on CD8 + T cells, activating caspase-8/3 cascades to trigger T-cell apoptosis and promote immune evasion. Notably, the finding indicated the non-redundant and synergistic effects of ACSS2 and AATF in modulating FasL expression, which might support emerging strategies for immunotherapy of PNETs.}, archive = {J_ADVS}, author = {Qin Dang and Ting Wang and Yan Wang and Zeng Ye and Borui Li and Xuan Pan and Zheng Li and Guixiong Fan and Desheng Jing and Junfeng Xu and Qiangsheng Hu and Shunrong Ji and Xiaowu Xu and Xianjun Yu and Yi Qin}, doi = {10.1002/advs.202506883}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06883}, shortjournal = {Adv. Sci.}, title = {ACSS2/AATF drives soluble FasL-mediated CD8+ t cell apoptosis in pancreatic neuroendocrine tumors}, volume = {12}, year = {2025}, }
• (2025). Developing a personalized cancer nanovaccine using coxsackievirus-reprogrammed cancer cell membranes for enhanced anti-tumor immunity. ADVS, 12(40), e06791. (www)

  @article{ , abstract = {Cancer vaccines emerge as a promising approach in immunotherapy, but their efficacy is often hindered by immunosuppressive factors like PD-L1 on tumor cell membranes. To address this challenge, a personalized nanovaccine is developed using membranes from Coxsackievirus B3 (CVB3)-infected 4T1 breast cancer cells combined with heat-deactivated CVB3 (hdCVB3) encapsulated in PLGA nanoparticles (PLGA@hdCVB3I4T1M). RNA sequencing reveals significant upregulation of immune activation-related genes, while protein analysis demonstrates reduced immunosuppressive markers (PD-L1, B7-H3, CD47) and increased immunostimulatory proteins (calreticulin), enhancing immune cell uptake and activation. In vitro and in vivo studies confirm the safety and potent immunostimulatory effects of PLGA@hdCVB3I4T1M, leading to enhanced immune cell infiltration, elevated proinflammatory cytokine production, and robust antitumor responses. The nanovaccine significantly improves tumor suppression and prolongs survival in animal models. Additionally, the inclusion of hdCVB3 amplified immune recognition of both viral and tumor antigens, further enhancing therapeutic efficacy, particularly when combined with oncolytic virotherapy. Mechanistically, this strategy primes the immune system for a more effective and sustained antitumor response. In summary, PLGA@hdCVB3I4T1M effectively stimulates the immune system, overcoming tumor immune evasion. This nanovaccine represents a promising strategy for enhancing cancer immunotherapy and holds strong potential for clinical translation, particularly in combination with oncolytic virotherapy.}, archive = {J_ADVS}, author = {Amirhossein Bahreyni and Yasir Mohamud and Amrit Singh and Razieh Sadat Banijamali and Jeffrey Tang and Jingchun Zhang and Honglin Luo}, doi = {10.1002/advs.202506791}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06791}, shortjournal = {Adv. Sci.}, title = {Developing a personalized cancer nanovaccine using coxsackievirus-reprogrammed cancer cell membranes for enhanced anti-tumor immunity}, volume = {12}, year = {2025}, }
• (2025). Vertical GaN-on-GaN micro-LEDs for near-eye displays. ADVS, 12(40), e06784. (www)

  @article{ , abstract = {In various micro-light-emitting diode (micro-LED) display products, near-eye applications such as AR (augmented reality) and VR (virtual reality) are gaining popularity, driving consumer demand for higher brightness, resolution, and compact size. To address more advanced demands, GaN-on-GaN homoepitaxial micro-LEDs are notable for their low defect density, excellent thermal management, high efficiency, etc. Additionally, the conductivity of the GaN substrate enables the efficient integration of vertical micro-LEDs, further enhancing performance for near-eye displays. In this work, GaN-on-GaN homoepitaxial platforms to fabricate low-defect-density micro-LEDs are leveraged with superior electrical properties, addressing the limitations of conventional heterogeneous substrates. By replacing traditional ICP (Inductively coupled plasma) mesa etching with fluorine ion implantation for pixel isolation, this study achieves significant reductions in series resistance and enhances optical performance, characterized by sharper pixel edges and a narrowed full width at half maximum (FWHM). Furthermore, the implementation of vertical micro-LED architectures enables a compact device footprint, facilitating ultra-dense integration for near-eye systems. To evaluate performance under practical operating conditions, the effective external quantum efficiency (EQE effective ) is introduced. The ion-implanted vertical structures demonstrate a substantial improvement in EQE effective over traditional ICP-etched devices, underscoring their potential for high-brightness applications. This work advances high-resolution, energy-efficient micro-LED technologies, offering a scalable pathway for next-generation AR/VR displays.}, archive = {J_ADVS}, author = {Zichun Li and Yibo Liu and Haonan Jiang and Feng Feng and Jingyang Zhang and Shan Huang and Fion Yeung and Manchun Tseng and Man Wong and Hoi Sing Kwok and Zhaojun Liu}, doi = {10.1002/advs.202506784}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06784}, shortjournal = {Adv. Sci.}, title = {Vertical GaN-on-GaN micro-LEDs for near-eye displays}, volume = {12}, year = {2025}, }
• (2025). Macrophage zc3h12c limits tissue inflammation and injury via alternative splicing of pre-mRNA. ADVS, 12(40), e06707. (www)

  @article{ , abstract = {RNA-binding proteins regulate post-transcriptional gene translation, but the macrophage-specific role of Zc3h12c remains poorly characterized. Here, the role of Zc3h12c in macrophages is characterized using Tnfrsf11a Cre -Zc3h12c flox/flox mice. Both Tnfrsf11a and Zc3h12c are highly expressed in the kidney tissue from patients with chronic kidney disease and showed a positive association with an interstitial fibrosis score. Single cell RNA sequencing demonstrated abundant Tnfrsf11a expression in murine kidney macrophages and a correlation with the induction of chemokines, macrophage phagocytosis, and activation upon kidney injury. In various kidney injury models, Tnfrsf11a Cre -Zc3h12c flox/flox mice suffered from more injury and inflammation in the kidney, characterized by an increase in Ccr2 positive leukocyte infiltration. Mechanistic in vitro studies revealed that Zc3h12c suppresses macrophage activation toward a pro-inflammatory phenotype, modulates macrophage survival, migration, and phagocytosis. Both in silico and in vitro analysis indicated that Zc3h12c regulates the pro-inflammatory cytokines/chemokines and chemokine receptors expression and modulates the alternative splicing of pre-mRNAs STAT1. Thus, macrophage-derived Zc3h12c limits tissue inflammation and injury, potentially via alternate splicing of pre-mRNAs.}, archive = {J_ADVS}, author = {Chenyu Li and Julian Aurelio Marschner and Yoshihiro Kusunoki and Ningxin Zhang and Xiaoxin Li and Hao Deng and Zhibo Zhao and Kanako Watanabe-Kusunoki and Zhihui Zhu and Yan Xu and Stefanie Steiger and Maciej Lech and Katalin Susztak and Christian Schulz and Hans-Joachim Anders}, doi = {10.1002/advs.202506707}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06707}, shortjournal = {Adv. Sci.}, title = {Macrophage zc3h12c limits tissue inflammation and injury via alternative splicing of pre-mRNA}, volume = {12}, year = {2025}, }
• (2025). Lenvatinib plus paclitaxel as second-line therapy for advanced gastric cancer patients: A dose escalation exploratory study. ADVS, 12(40), e06678. (www)

  @article{ , abstract = {Second-line treatment options for advanced gastric cancer (AGC) patients remain limited. This dose escalation exploratory study is aimed to determine the maximum tolerated dose (MTD) of lenvatinib plus paclitaxel as second-line treatment in AGC and to explore molecular biomarkers using dynamic network biomarker (DNB) analysis. Eligible patients are treated with lenvatinib plus paclitaxel (135 mg m −2 , q3w). Dose escalation of lenvatinib adopts a “3 + 3” design. DNB analysis is performed based on Olink proteomics data using serial blood samples. Eleven patients are treated. No dose-limiting toxicities are observed, and the MTD of lenvatinib is determined as 16 mg. White blood cells decreased (45.5%, 5/11) is the most common adverse event. Grade ≥3 adverse event rate is 18.2% (2/11). Objective response rate is 36.4% (4/11), and median overall survival is 7.4 months. A DNBscore associated with patient prognosis and response to multitarget tyrosine kinase inhibitor (TKI) plus paclitaxel is established. Infiltration of cancer-associated fibroblasts in tumor microenvironment is positively associated with the DNBscore. In summary, lenvatinib plus paclitaxel is well tolerant and shows promising efficacy as a second-line regimen in AGC. The DNBscore can be a biomarker for multitarget TKI plus paclitaxel and provide critical clues for future research .}, archive = {J_ADVS}, author = {Chenfei Zhou and Jinling Jiang and Liting Guo and Wenqi Xi and Junwei Wu and Qu Cai and Jun Ji and Feng Qi and Jun Zhang}, doi = {10.1002/advs.202506678}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06678}, shortjournal = {Adv. Sci.}, title = {Lenvatinib plus paclitaxel as second-line therapy for advanced gastric cancer patients: A dose escalation exploratory study}, volume = {12}, year = {2025}, }
• (2025). Biodegradable zinc-based alloys for guided bone regeneration membranes: Feasibility, current status, and future prospects. ADVS, 12(40), e06513. (www)

  @article{ , abstract = {The guided bone regeneration (GBR) technique is an effective method for treating inadequate alveolar ridge bone mass. The choice of barrier membrane materials plays a crucial role in the success of this technique. Recently, biodegradable zinc (Zn)-based metallic barrier membranes have been extensively investigated as a novel option for alveolar bone defect repair. Although in vitro and animal studies using Zn-based GBR membranes have shown some promising results, it remains uncertain whether these successes can be replicated in humans. In this review article, the clinical requirements for GBR membranes are discussed and the feasibility of Zn-based alloys as a potential new option is assessed. Current advancements in the development of Zn-based GBR membranes through alloying, surface modification, composite methods, and additive manufacturing techniques are also summarized. Importantly, several challenges persist, including stress corrosion, creep, and the need to balance osteogenesis with antimicrobial efficacy, which must be addressed in future studies. Overall, Zn-based barrier membranes represent a biodegradable and multifunctional solution for enhancing bone regeneration in dental applications.}, archive = {J_ADVS}, author = {Kai Chen and Ping Li and Qiang Guan and Xuenan Gu and Li Zhao and Linjun Huang and Chenyang Huang and Yu Qin and Chunhao Yu and Ting Zhang and Hejia Li and Yongcan Huang and Yufeng Zheng}, doi = {10.1002/advs.202506513}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06513}, shortjournal = {Adv. Sci.}, title = {Biodegradable zinc-based alloys for guided bone regeneration membranes: Feasibility, current status, and future prospects}, volume = {12}, year = {2025}, }
• (2025). Molecular design of a naturally derived hemostatic sealant with prolonged antimicrobial activity for repairing elastic organ injuries. ADVS, 12(40), e06466. (www)

  @article{ , abstract = {Hemorrhaging injuries on dynamic internal organs present significant clinical burdens due to their complex nature. To address therapeutic challenges, an injectable, photocrosslinkable, and multifunctional bioadhesive hydrogel comprising methacrylated gelatin (GelMAG), methacrylated dopamine (DMA), and poly(diallyldimethylammonium chloride) (pDDA), named GDP, is engineered. The hydrogel combined underwater adhesion, antimicrobial activity, and hemostatic performance with high elasticity, biomimetic stiffness, and biocompatibility. The GDP hydrogel displayed >200% elongation and ≈50 kPa Young's modulus in tensile tests. The bioadhesive strongly adhered (>40 kPa strength) to skin, outperforming commercial sealants Coseal and Evicel, and could seal various sizes and shapes of injuries created on explanted pig lungs. Broad-spectrum and long-term in vitro antibacterial activity is noted. During in vivo rat liver puncture and tail amputation, GDP achieved significantly reduced blood loss (≈65%) compared to commercial hemostat Surgicel in some cases. In a clinically relevant porcine lung laceration model, GDP sealed large defects and reduced blood loss by 45–55% compared to Surgicel and hemostatic sealant TISSEEL. It also supported enhanced wound closure and tissue regeneration with minimal inflammation. Ultimately, these findings showcased the potential of GDP to act as an elastic, antibacterial, and hemostatic sealant for the repair of multi-dimensional traumatic injuries on soft, dynamic tissues.}, archive = {J_ADVS}, author = {Saumya Jain and Avijit Baidya and Joshua A. Boys and George Z. Cheng and Taichiro Imahori and Naoki Kaneko and Nasim Annabi}, doi = {10.1002/advs.202506466}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06466}, shortjournal = {Adv. Sci.}, title = {Molecular design of a naturally derived hemostatic sealant with prolonged antimicrobial activity for repairing elastic organ injuries}, volume = {12}, year = {2025}, }
• (2025). CGRP-loaded ROS-responsive hydrogel restores neuro-angiogenic signaling to promote bone regeneration in diabetes-associated periodontitis. ADVS, 12(40), e06438. (www)

  @article{ , abstract = {Diabetes exacerbates the development and progression of periodontitis through the aggravation of persistent inflammation and tissue destruction. While the impact of diabetes on peripheral sensory nerves is well-documented, little is known about the role of diabetic neuropathy in bone destruction in diabetes-associated periodontitis. Herein, a significant loss of periodontal nerves is observed in the diabetic state of db/db mice, with trigeminal ganglion neurons showing decreased autophagy. These mice exhibit decreased density of calcitonin gene-related peptide (CGRP) + nerves, correlating with the progression of diabetes and inflammatory state. Furthermore, diabetic mice with periodontitis show greater alveolar bone loss, which can be phenocopied by periodontal denervation. Importantly, CGRP receptor-related components are found to be expressed in periodontal endothelial cells. In both diabetic and denervated periodontium, the loss of CGRP signaling is associated with the reduction of type H vessel density and coupled osterix + osteoprogenitors. To elaborate further, an injectable reactive oxygen species-responsive poly(vinyl alcohol) (PVA)/tsPBA hydrogel is developed for sustained CGRP delivery. Notably, the CGRP-loaded hydrogels promote alveolar bone regeneration via inducing type H vessel formation in diabetic mice. The findings highlight that diabetes-induced sensory nerve damage may exacerbate periodontitis-induced bone loss, and CGRP@PVA/tsPBA hydrogels offer a promising therapeutic strategy for bone regeneration.}, archive = {J_ADVS}, author = {Chaoning Zhan and Qingyi Dai and Jianhan Ren and Lijian Jin and Weiping Wang and Zhou Ye and James Kit Hon Tsoi and Yifan Lin}, doi = {10.1002/advs.202506438}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06438}, shortjournal = {Adv. Sci.}, title = {CGRP-loaded ROS-responsive hydrogel restores neuro-angiogenic signaling to promote bone regeneration in diabetes-associated periodontitis}, volume = {12}, year = {2025}, }
• (2025). Shear stress targeted delivery of nitroglycerin to brain collaterals improves ischaemic stroke outcome. ADVS, 12(40), e06276. (www)

  @article{ , abstract = {In patients with ischaemic stroke, retrograde perfusion of the penumbra by leptomeningeal collateral vessels (LMCs) strongly predicts clinical outcome, suggesting that enhancing LMC flow can offer a novel therapeutic approach. Using in vivo measurements and computational modelling it is shown that LMCs experience elevated fluid shear stress that is significantly higher than that in other blood vessels during ischaemic stroke in rats and humans. We exploit this to selectively enhance flow in LMCs using shear-activated nanoparticle aggregates carrying the vasodilator nitroglycerin (NG-NPAs) that specifically release drug in regions of vessels with high wall shear stress (≥100 dyne cm −2 ). NG-NPAs significantly increased LMC-mediated penumbral perfusion, decreased infarct volume, and reduced neurological deficit without altering systemic blood pressure in a rat ischaemic stroke model. NG-NPAs also avoided common side effects of systemic nitrate administration, such as systemic hypotension, cerebral vascular steal, cortical vein dilation, or intracranial pressure elevation. Systemic administration of free NG at the maximal tolerated dose, which is ten times higher than the dose of NG used in the NG-NPAs, do not enhance LMC perfusion and dropped blood pressure. Thus, packaging NG within shear-activated NPAs can potentially enable this widely available vasodilator to become a highly effective therapeutic for ischaemic stroke.}, archive = {J_ADVS}, author = {Magdalena Litman and Sara Azarpeykan and Rebecca J Hood and Kristy Martin and Debbie Pepperall and Daniel Omileke and Fern Williams and Oktay Uzun and Deen Bhatta and Yuen K Yong and Alex Chan and Nicholas Hough and Sarah Johnson and Pablo Garcia Bermejo and Ferdinand Miteff and Carlos Garcia Esperon and Yvonne Couch and Alastair M Buchan and Neil J Spratt and Netanel Korin and Donald E Ingber and Daniel J Beard}, doi = {10.1002/advs.202506276}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06276}, shortjournal = {Adv. Sci.}, title = {Shear stress targeted delivery of nitroglycerin to brain collaterals improves ischaemic stroke outcome}, volume = {12}, year = {2025}, }
• (2025). Enhanced bifunctional electrocatalysis for zinc-air battery using porous conductive substrate with abundant anchoring sites. ADVS, 12(40), e06172. (www)

  @article{ , abstract = {Efficient and robust bifunctional electrocatalysts for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) are critical for high-performance zinc-air batteries (ZABs). However, balancing OER and ORR activity in a single catalyst remains challenging due to the different mechanisms during charging and discharging. Here, a scalable strategy is presented for enhancing both reactions by integrating two-dimensional OER- and ORR-active components onto a carbon-based conductive substrate with abundant anchoring sites, via high-shear exfoliation. The heterostructure catalyst demonstrates exceptional bifunctionality, achieving an extremely low overpotential difference of 0.63 V. First-principles calculations confirm a strong chemical compatibility between the active components and substrate. In scaled-up ZAB applications, the catalyst delivers a high peak power density of 1569 mW cm −2 , and an outstanding cycling stability over 300 h (1800 cycles). This work highlights a versatile approach for designing multifunctional electrocatalysts, advancing scalable energy conversion and storage technologies.}, archive = {J_ADVS}, author = {Jongkyoung Kim and Je Min Yu and Jun-Yong Choi and Seong-Hun Lee and Han Uk Lee and Dongrak Oh and Hyunju Go and Wonsik Jang and Seunghyun Lee and Jaewon Cho and Sung Beom Cho and Tae Joo Shin and Hyunjoo Lee and Sang-Goo Lee and Ji-Wook Jang and Seungho Cho and Wook Jo}, doi = {10.1002/advs.202506172}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e06172}, shortjournal = {Adv. Sci.}, title = {Enhanced bifunctional electrocatalysis for zinc-air battery using porous conductive substrate with abundant anchoring sites}, volume = {12}, year = {2025}, }
• (2025). From bench to bedside: Emerging paradigms in CAR-T cell therapy for solid malignancies. ADVS, 12(40), e05822. (www)

  @article{ , abstract = {Immunotherapy, particularly chimeric antigen receptor T cell (CAR-T) therapy, has revolutionized the treatment of hematological malignancies and autoimmune diseases. However, its efficacy in solid tumors remains limited due to challenges such as tumor heterogeneity, an immunosuppressive microenvironment, and poor T cell infiltration. This review first summarizes the primary causes and challenges that restrict CAR-T therapy in the treatment of solid tumors, followed by an overview of recent advancements in gastric cancer, liver cancer, and glioma, where early trials have demonstrated promising clinical potential. Advances in CRISPR-edited and “off-the-shelf” allogeneic CAR-T cells seek to improve scalability, while artificial intelligence (AI)-driven target discovery, synthetic biology, and cytokine armoring strategies aim to enhance tumor specificity and T-cell persistence. Additionally, the flexible utilization of combination strategies in clinical surgical and medical trials, such as combining CAR-T therapy with immune checkpoint inhibitors, oncolytic viruses, chimeric antigen receptor NK cells (CAR-NK), or chimeric antigen receptor macrophage cells (CAR-M) may further enhance antitumor efficacy. The evolution of CAR-T therapy highlights its potential to reshape precision oncology, offering hope to patients with aggressive solid tumors through ongoing basic research, technological optimization, and clinical refinement.}, archive = {J_ADVS}, author = {Yang Chen and Ran Ren and Lirong Yan and Yu Zhou and Ruokai Sun and Huicong Song and Hongfei Yan and Yongsheng Li}, doi = {10.1002/advs.202505822}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e05822}, shortjournal = {Adv. Sci.}, title = {From bench to bedside: Emerging paradigms in CAR-T cell therapy for solid malignancies}, volume = {12}, year = {2025}, }
• (2025). ZDHHC12 palmitoylates HDAC8 to promote the progression of hepatocellular carcinoma associated with a diet high in saturated fatty acids. ADVS, 12(40), e05702. (www)

  @article{ , abstract = {Excessive intake of saturated fatty acids (SFAs)—commonly associated with diets rich in fried foods and red meat—significantly increases the risk of hepatocellular carcinoma (HCC). Palmitic acid (PA), the most prevalent type of SFA, is selected as the representative model for this study. Palmitoyltransferases play crucial roles in protein palmitoylation mediated by PA; however, the most significantly altered palmitoyltransferase under high-SFA dietary conditions remains unidentified. This study reveals zinc finger DHHC-type palmitoyltransferase 12 (ZDHHC12) as a key protein in PA-driven HCC progression that functions by stabilizing the oncogenic histone deacetylase 8 (HDAC8). Mechanistically, PA supplementation upregulates ZDHHC12 expression by activating the transcription factor SWI/SNF-related BAF chromatin remodeling complex subunit ATPase 4 (SMARCA4). ZDHHC12 mediates HDAC8 palmitoylation at cysteine 244, thereby inhibiting its lysosomal degradation and ultimately promoting HCC progression. This study reveals that ZDHHC12 is a critical mediator of PA-induced HCC progression and that targeting HDAC8 can suppress this process. These findings offer a potential therapeutic strategy for HCC patients with high dietary intake of SFAs, particularly PA.}, archive = {J_ADVS}, author = {Xin Jin and Yulong Hong and Yongqi Zhao and Wensheng Shi and Ruilin Liu and Xinyu You and Chong Yang and Yu Zhang}, doi = {10.1002/advs.202505702}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e05702}, shortjournal = {Adv. Sci.}, title = {ZDHHC12 palmitoylates HDAC8 to promote the progression of hepatocellular carcinoma associated with a diet high in saturated fatty acids}, volume = {12}, year = {2025}, }
• (2025). Bioinspired brush reinforced solid slippery coatings for marine photovoltaic protection. ADVS, 12(40), e05526. (www)

  @article{ , abstract = {Plant cuticles exhibit exceptional liquid repellence and self-healing properties through brush-like cutin-wax nanostructures, providing inspiration for the multifunctional slippery materials. Here, a plant cuticle-inspired solid slippery surface (PI-SSS) is introduced based on surface-grafted polymer brushes, which act as a stable molecular matrix to enhance the adhesion strength of lubricating copolymer and the substrate (≈0.96 MPa) via strong ion-dipole interactions. The resultant PI-SSS demonstrates excellent optical transmittance (≈91.3%) and liquid repellence, particularly against crude oil, alongside multifunctional anti-biofouling properties (e.g., proteins, chlorella, and mussels). The durability of the coating is validated under extreme conditions, such as prolonged acid and base solution exposure, repeated adhesion/peeling cycles, and seawater immersion, while maintaining its slippery behavior. These features significantly protect solar cells from harsh environments, ensuring a photoelectric conversion efficiency of 15.8% and a stable output voltage of approximately 2.0 V after continuous UV irradiation for a week, and 50 cycles of thermal tests between -15 °C and 100 °C, offering a promising approach for marine solar photovoltaic protection.}, archive = {J_ADVS}, author = {Ling Yin and Runxiang Tan and Junyi Han and Jianing Wang and Jianjun Cheng and Daheng Wu and Tao Zhang and Liping Wang}, doi = {10.1002/advs.202505526}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e05526}, shortjournal = {Adv. Sci.}, title = {Bioinspired brush reinforced solid slippery coatings for marine photovoltaic protection}, volume = {12}, year = {2025}, }
• (2025). Decoding handwriting trajectories from intracortical brain signals for brain-to-text communication. ADVS, 12(40), e05492. (www)

  @article{ , abstract = {The potential to decode handwriting trajectories from brain signals has yet to be fully explored in clinical brain-computer interfaces (BCIs). Here, intracortical neural signals are recorded from a paralyzed individual during attempted handwriting of complex characters. An innovative decoding framework is introduced to address both shape and temporal distortions between neural activity and movement, effectively resolving the misalignment issue commonly encountered in clinical BCIs due to the lack of accurate movement labels. The results demonstrated the reconstruction of highly accurate and human-recognizable handwriting trajectories, significantly outperforming conventional methods. Furthermore, the new framework enabled effective multi-day data fusion, leading to additional improvements in trajectory quality. By employing a dynamic time warping approach to translate trajectories into text, a recognition rate up to 91.1% is achieved within a 1000-character database. Additionally, the framework is applied to reconstruct single-trial trajectories of English letters using a previously published dataset, achieving similarly high recognition rates. Collectively, these findings present a novel BCI decoding scheme capable of accurately reconstructing handwriting trajectories, demonstrating its applicability to both alphabetic and logographic brain-to-text translation. This approach has the potential to revolutionize communication for individuals with motor impairments by enabling accurate brain-to-text translation across diverse languages.}, archive = {J_ADVS}, author = {Guangxiang Xu and Zebin Wang and Kedi Xu and Junming Zhu and Jianmin Zhang and Yueming Wang and Yaoyao Hao}, doi = {10.1002/advs.202505492}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e05492}, shortjournal = {Adv. Sci.}, title = {Decoding handwriting trajectories from intracortical brain signals for brain-to-text communication}, volume = {12}, year = {2025}, }
• (2025). Acidosis forces fatty acid uptake and metabolism in cancer cells regardless of genotype. ADVS, 12(40), e05436. (www)

  @article{ , abstract = {While proteins facilitate fatty acid (FA) partitioning into plasma membranes, movement between membrane leaflets occurs through a “flip-flop” mechanism. This study provides evidence that biological acidosis, as encountered in tumors and ischemic diseases, promotes FA protonation, thereby enhancing neutral, non-ionized FA uptake. This positions the altered lipid metabolism in acid-exposed cells as a consequence, rather than a cause, of preferential FA uptake. Cancer cell vulnerability, independent of their genetic background, directly stems from this paradigm shift, as detoxifying the overload of very long-chain FA (VLCFA) becomes highly dependent on peroxisomal activity. Inhibition of peroxisomal function in acid-exposed cancer cells leads to the rerouting of these fatty acids into triglycerides within lipid droplets, but also into phospholipids, contributing to membrane alterations, triggering ER stress, and ultimately supporting cytotoxicity. Using patient-derived tumor organoids and sera from human volunteers supplemented with polyunsaturated FA (PUFA), it is shown that inhibiting peroxisomal ACOX1 selectively kills acid-exposed cancer cells, an effect exacerbated by pharmacological stimulation of glycolysis. Similar acid-driven FA uptake is observed in endothelial cells and cardiac myocytes, opening new therapeutic avenues not only cancer but also cardiovascular diseases.}, archive = {J_ADVS}, author = {Sébastien Ibanez and Maria Virginia Giolito and Sultan Al-Siyabi and Kristian Serafimov and Florine Laloux and Emeline Dierge and Léo Aubert and Céline Guilbaud and Selena Kaye and Paula Varon and Dorothée Marchand and Hanne Vlieghe and Emmanuel Hermans and Caroline Bouzin and Davide Brusa and Christiani Andrade Amorim and Barabara Pachikian and Yvan Larondelle and Cyril Corbet and Chantal Dessy and Olivier Feron}, doi = {10.1002/advs.202505436}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e05436}, shortjournal = {Adv. Sci.}, title = {Acidosis forces fatty acid uptake and metabolism in cancer cells regardless of genotype}, volume = {12}, year = {2025}, }
• (2025). Targeting methylglyoxal metabolism to enhance ferroptosis sensitivity in tumor therapy. ADVS, 12(40), e05356. (www)

  @article{ , abstract = {Ferroptosis, characterized by iron-dependent lipid peroxidation, is a form of oxidative cell death increasingly recognized for its role in cancer therapy. The susceptibility of cancer cells to ferroptosis varies, highlighting the need to elucidate its underlying metabolic mechanisms. This study identifies a novel pathway in which the E3 ubiquitin ligase, praja ring finger ubiquitin ligase 1 (PJA1), mediates the proteasomal degradation of glyoxalase I (GLO1) exclusively in ferroptosis-sensitive cancer cells. This degradation pathway is absent in ferroptosis-resistant cells, resulting in differing management of methylglyoxal (MGO). The accumulation of MGO, as opposed to its clearance, facilitates ferroptosis by promoting the autophagic degradation of key anti-ferroptotic proteins, specifically ferritin and glutathione peroxidase 4 (GPX4). Targeting the PJA1-GLO1 axis through genetic and pharmacological means enhances the sensitivity of tumors to ferroptosis inducers across various preclinical models, including xenografts, orthotopic, and patient-derived models. Additionally, clinical data demonstrate that elevated GLO1 expression is associated with poorer survival outcomes in pancreatic cancer patients. These findings suggest that modulating the MGO metabolism pathway, particularly through targeting the PJA1-GLO1 axis, can amplify the effectiveness of ferroptosis-inducing agents in cancer therapy.}, archive = {J_ADVS}, author = {Xinyue Zhang and Leng Han and Zimu Wang and Hanghui Yu and Jiao Liu and Rui Kang and Daolin Tang and Zhengjia Liu and Xianlong Du and Enyong Dai}, doi = {10.1002/advs.202505356}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e05356}, shortjournal = {Adv. Sci.}, title = {Targeting methylglyoxal metabolism to enhance ferroptosis sensitivity in tumor therapy}, volume = {12}, year = {2025}, }
• (2025). Wide-/Narrow-bandgap heterojunction for high performance differential photodetector with tunable response. ADVS, 12(40), e04872. (www)

  @article{ , abstract = {Amid the rapid advancement in modern photonics and artificial intelligence, optoelectronic devices with enhanced functionalities and high performance hold great promise for complex photonic integrated circuits. Herein, a novel tunable differential photodetector (DPD) is developed based on a wide-/narrow-bandgap semiconductor heterojunction, featuring a large conduction band offset at the heterojunction interface. Benefiting from the unique band alignment at the heterojunction interface, this device exhibits interesting characteristics:1) It offers two tunable operational modes, freely switchable between “differential mode” and “normal mode” only by adjusting the bias voltages; 2) While operating in “differential mode” under zero bias, the DPD exhibits high detectivity (4.5×10 11 Jones) and broad bandwidth of ≈1 MHz under 1550 nm laser at room temperature; 3) Due to the narrow bandgap of PbSe, the device operates at longer wavelengths than reported to date. An equivalent circuit model is proposed to elucidate the working mechanism that is experimentally observed. The practical applications of the DPD in the event-based imaging of a moving flame and encrypted communication are further demonstrated. The work establishes a novel approach for optoelectronic devices toward multifunctional integrated photonics applications.}, archive = {J_ADVS}, author = {Ziyang Ren and Haimin Zhu and Weien Lai and Yihui Zhai and Mengjuan Liu and Yu Zhu and Hanlun Xu and Nasir Ali and Ning Dai and Jiaqi Zhu and Sihan Zhao and Huizhen Wu}, doi = {10.1002/advs.202504872}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e04872}, shortjournal = {Adv. Sci.}, title = {Wide-/Narrow-bandgap heterojunction for high performance differential photodetector with tunable response}, volume = {12}, year = {2025}, }
• (2025). Arginine metabolic disruption impairs hair regeneration via ROS-mediated inactivation of mTOR signaling in androgenetic alopecia. ADVS, 12(40), e04579. (www)

  @article{ , abstract = {Androgenetic alopecia (AGA), a pervasive hair loss disorder, lacks effective therapies due to incomplete pathogenic understanding. Growing evidence suggests a connection between AGA and metabolic disorders. Leveraging unbiased serum metabolomics, a strikingly differentiated metabolic signature in AGA patients compared to healthy controls is identified, with arginine deficiency exhibiting the most pronounced reduction among all amino acids. Concomitant downregulation of the arginine transporter SLC7A1 and upregulation of arginine catabolic enzyme ARG2 in balding HFs are further identified, collectively driving localized arginine scarcity through impaired uptake and accelerated catabolism. This metabolic perturbation triggers pathological reactive oxygen species (ROS) accumulation in hair follicles (HFs), which, in turn, inhibits mTOR signaling and impairs HF regeneration. Conversely, arginine restoration via exogenous supplementation or inhibiting arginine-to-ornithine conversion with ARG2 siRNA rescues hair growth in both murine AGA model and cultured human HFs. Most importantly, a microneedle-based delivery system for targeted dermal arginine replenishment demonstrates robust therapeutic efficacy in humanized AGA models. This work establishes arginine insufficiency as a core pathogenic driver in AGA and validates localized metabolic correction as a promising clinical strategy.}, archive = {J_ADVS}, author = {Shixin Duan and Guo Li and Yanji Chu and Junbo Zhang and Li Yang and Yujin Zhang and Fangfen Liu and Jiayun Li and Mengting Chen and Ben Wang and Zhixiang Zhao and Wei Shi and Yiya Zhang and Guangtong Deng and Xinwei Kuang and Hongfu Xie and Yufan Cheng and Zhili Deng and Ji Li and Yan Tang}, doi = {10.1002/advs.202504579}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e04579}, shortjournal = {Adv. Sci.}, title = {Arginine metabolic disruption impairs hair regeneration via ROS-mediated inactivation of mTOR signaling in androgenetic alopecia}, volume = {12}, year = {2025}, }
• (2025). Personalized medication for chronic diseases using multimodal data-driven chain-of-decisions. ADVS, 12(40), e04079. (www)

  @article{ , abstract = {The precise matching of medication regimens to individual patients, known as personalized medication, is critical for the effective management of chronic diseases. Traditional machine learning-based models for personalized medication regimens typically rely solely on either clinical macro-phenotypes or molecular-level drug characteristics. It remains challenging to capture the patient-medication relationship from a comprehensive perspective that integrates individual patient characteristics with macro- and micro-level properties of the medication. Determining patient-medication relationships constitutes a three-stage sequential decision process from a clinical decision-making perspective. Therefore, inspired by Chain-of-Thought prompting, which simulates the decision-making process of human experts, a Multimodal Data-Driven Chain-of-Decisions (MDD-CoD) framework is proposed, where three-stage deep learning tasks are sequentially organized to reflect upstream–downstream logical dependencies, thereby forming a coherent clinical decision-making process. The model incorporates multimodal clinical phenotype data, multi-attribute medication data, and insights from clinical experts. Performance evaluation of the model involved comprehensive experiments utilizing five datasets covering four chronic diseases sourced from three hospitals. The dataset comprises information from chronic kidney disease (CKD), membranous nephropathy (MN), rheumatoid arthritis (RA), colorectal cancer (CRC), and knee osteoarthritis (KOA), totaling 3173 unimodal, 502 multimodal, and 2187 medication records from 3675 patients. Experimental results demonstrate that the framework achieves enhanced predictive performance in personalized medication decision-making based on individual patient disease characteristics, surpassing the strongest baseline across all tasks. This framework serves as a foundational model for clinical mixed data, with improved generalization and interpretability in cross-disease personalized decision-making tasks. It offers a scalable solution for the implementation of personalized medication regimens for chronic diseases.}, archive = {J_ADVS}, author = {Xiaoli Chu and Yiheng Ye and Siqiao Tang and Miaoru Han and Guowei Wang and Shuai Lin and Bingzhen Sun and Qingchun Huang and Yan Zhang and Xiaodong Chu and Kun Bao}, doi = {10.1002/advs.202504079}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e04079}, shortjournal = {Adv. Sci.}, title = {Personalized medication for chronic diseases using multimodal data-driven chain-of-decisions}, volume = {12}, year = {2025}, }
• (2025). Beyond metal-air chemistry: Coupling n-/p-type organic redox chemistry toward sustainable sub-zero-temperature all-polymer seawater batteries. ADVS, 12(40), e04004. (www)

  @article{ , abstract = {Developing high-efficiency durable rechargeable seawater battery (RSB) that directly harnesses natural seawater for sustainable energy storage is an attractive yet challenging task. Rather than use traditional metal-air chemistry, for the first time it proposes a coupled n-type/p-type redox chemistry to establish a new all-polymer RSB (APRSB) with high energy efficiency and long cycle lifespan even at subzero temperature. The strategy involves rational design of n-type redox polyimide (NDIP) and p-type redox radical polymer (RRP). By using flexible triamine linker to crosslink naphthalenetetracarboxylic dianhydride (NTCDA) molecules to tune aggregate structures, the newly-produced NDIP attains consistent high storage capacity for multiple cations (Na + /K + /Mg 2+ /Ca 2+ ), enabling seawater-adaptable low-potential anodes with fast redox kinetics and large specific capacity along with long lifespan over 10 000 cycles—superior to most previous electrodes in seawater. By exerting inherent advantages of radicals, RRP is explored as seawater-suitable well-matched high-potential cathodes, integrating facile redox property and superior adaptability with SO 4 2− and even the corrosive Cl − . Thus, paring NDIP and RRP yields APRSB with high output voltage, large energy efficiency (81%), and 83.2% capacity retention after 800 cycles even at −4 °C—outperforming most previous room-temperature seawater batteries. Detailed studies reveal facilitated organic redox kinetics in seawater resistive against low temperature.}, archive = {J_ADVS}, author = {Yuanzhe Lu and Xiu Liu and Fan Yang and Zishou Zhang and Fei Xin and Linfeng Zhong and Dingshan Yu}, doi = {10.1002/advs.202504004}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e04004}, shortjournal = {Adv. Sci.}, title = {Beyond metal-air chemistry: Coupling n-/p-type organic redox chemistry toward sustainable sub-zero-temperature all-polymer seawater batteries}, volume = {12}, year = {2025}, }
• (2025). Regulation of neuroinflammation by microglial DUBA-IRAK1-IKKβ signaling loop. ADVS, 12(40), e03972. (www)

  @article{ , abstract = {Activation of microglia is closely associated with neuroinflammation. However, the cell-intrinsic molecular mechanisms translating microglia activation into neuroinflammation are only partially understood. Here, it is shown that deubiquitinating enzyme A (DUBA) is upregulated in microglia under neuroinflammatory conditions in both mice and humans. Mechanistically, activation of microglia induces DUBA self-deubiquitination and stabilization, leading to the rapid upregulation of DUBA protein levels. In turn, stabilized DUBA increases proinflammatory gene induction in activated microglia by enhancing the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling. Of note, DUBA promotes NF-κB and MAPK activation by stabilizing interleukin-1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination. Importantly, specific ablation of DUBA in microglia mitigates lipopolysaccharide-induced depression-like behavior and ischemic stroke injury in mice by limiting neuroinflammation. Collectively, these findings establish DUBA as a key regulator of microglia in neuroinflammation and uncover novel molecular mechanisms for DUBA in inflammatory signal transduction.}, archive = {J_ADVS}, author = {Zhenhu Zhu and Zhongding Li and Kate Lykke Lambertsen and Zijun Cao and Meng Chen and Yanqi Xu and Bettina Hjelm Clausen and Keshuo Jin and Yiting Lu and Fuqi Mei and Xue Du and Kangmin Chen and Huiyuan Bai and Xian Su and Bincheng Zhou and Baohua Liu and Ran Li and Chaoqun Wang and Yuhua Li and Xiang Cai and Dirk Schlüter and Weihong Song and Xu Wang}, doi = {10.1002/advs.202503972}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e03972}, shortjournal = {Adv. Sci.}, title = {Regulation of neuroinflammation by microglial DUBA-IRAK1-IKKβ signaling loop}, volume = {12}, year = {2025}, }
• (2025). Toward a species search engine: KISSE offers a rigorous statistical framework for bone collagen tandem mass spectrometry data. ADVS, 12(40), e03963. (www)

  @article{ , abstract = {DNA and bone collagen are two key sources of resilient molecular markers used to identify species from their remains. Collagen is more stable than DNA, and thus it is preferred for ancient and degraded samples. Current mass spectrometry-based collagen sequencing approaches are empirical and lack a rigorous statistical framework. Based on the well-developed approaches to protein identification in shotgun proteomics, a first approximation of the species search engine (SSE) is introduced. SSE named KISSE is based on a species-specific library of collagenous peptides that uses both peptide sequences and their relative abundances. The developed statistical model can identify the species and the probability of correct identification, as well as determine the likelihood of the analyzed species not being in the library. The advantages and limitations of the proposed approach, and the possibility of extending it to other tissues is discussed.}, archive = {J_ADVS}, author = {Hassan Gharibi and Amir Ata Saei and Alexey L. Chernobrovkin and Susanna L. Lundstrom and Hezheng Lyu and Zhaowei Meng and Akos Vegvari and Massimilliano Gaetani and Roman A. Zubarev}, doi = {10.1002/advs.202503963}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e03963}, shortjournal = {Adv. Sci.}, title = {Toward a species search engine: KISSE offers a rigorous statistical framework for bone collagen tandem mass spectrometry data}, volume = {12}, year = {2025}, }
• (2025). Hepatic ENTPD5 is critical for maintaining metabolic homeostasis and promoting brown adipose tissue thermogenesis. ADVS, 12(40), e03603. (www)

  @article{ , abstract = {Although hepatocyte-released adenosine triphosphate (ATP) plays important roles in maintaining metabolic homeostasis, how its hydrolyzation outside hepatocytes impacts on glucolipid metabolism remains unclear. The authors aim to identify the enzyme(s) that hydrolyzes hepatocyte-secreted ATP to regulate metabolic homeostasis. All known ATP-hydrolyzing enzymes are expressed with the highest expression of ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) in hepatocytes. ENTPD5 expression is reduced in steatotic mouse and human livers. Hepatic ENTPD5 overexpression ameliorates the deregulated glucolipid metabolism and obesity with increased brown adipose tissue (BAT) thermogenesis, while hepatic ENTPD5 silencing exerted the opposite effects in obese mice. Mechanistically, ENTPD5 hydrolyzes extracellular ATP to ADP, which activates purinergic receptor, P2Y 12 , to inhibit gluconeogenesis and lipid deposition, and repress adrenomedullin (ADM) expression. Hepatic ENTPD5 repression promotes ADM expression and release to inhibit uncoupling protein 1 (UCP1) expression and thermogenesis in BAT. Hepatic ADM expression is increased in NAFLD patients. Serum ADM level is correlated positively with Body mass index in overweighted or obese humans. Hepatic ADM silencing promotes UCP1 expression and thermogenesis in BAT of obese mice. Overall, ENTPD5-mediated hydrolysis of extracellular ATP to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting BAT thermogenesis by inhibiting ADM expression and secretion.}, archive = {J_ADVS}, author = {Rufeng Ma and Song Hou and Rui Xiang and Wenjun Liu and Xin Li and Yujing Chi and Ming Xu and Haochen Yao and Jing Li and Jichun Yang}, doi = {10.1002/advs.202503603}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e03603}, shortjournal = {Adv. Sci.}, title = {Hepatic ENTPD5 is critical for maintaining metabolic homeostasis and promoting brown adipose tissue thermogenesis}, volume = {12}, year = {2025}, }
• (2025). SENP6 maintains mitochondrial homeostasis by regulating mitochondrial protein import through deSUMOylation of TOM40. ADVS, 12(40), e03408. (www)

  @article{ , abstract = {SUMOylation, a reversible post-translational modification, regulates various mitochondrial processes, including biogenesis, dynamics, mitophagy, and the mitochondrial unfolded protein response. Although SUMOylation is shown to be triggered by mitochondrial protein import failure in yeast, its impact on mammalian mitochondrial protein import remains unclear. Here, it is demonstrated that SENP6 knockdown-induced SUMOylation causes loss of mitochondrial proteostasis, which impairs mitochondrial morphology and function. Mechanistically, SENP6 knockdown dampens TOM complex assembly by SUMOylating TOM40, thereby hindering the mitochondrial protein import process, including TOM40 precursor, and ultimately disrupts mitochondrial homeostasis. Additionally, it is observed that CCCP treatment resulted in a decrease of SENP6 within mitochondria fraction, accompanied by increased TOM40 SUMOylation in the brains of 3×Tg-Alzheimer's disease (AD) mice or Aβ 1-42 peptide-stimulated cells. Collectively, the results suggest that Aβ 1-42 accumulation may enhance TOM40 SUMOylation by suppressing SENP6, thereby impairing mitochondrial homeostasis through protein import failure and potentially contributing to the pathological process of AD. This study elucidates the role of TOM40 SUMOylation/deSUMOylation in regulating the mitochondrial import process during mitochondrial stress.}, archive = {J_ADVS}, author = {Liubing Hu and Jianshuang Li and Haolin Guo and Lei Su and Peina Dong and Juan Huang and Yanyan Liu and Xinjie Liu and Zhenhuan Luo and Wei Xiong and Zhenyu Ju and Qinghua Zhou and Hao Wang and Wenjun Wang}, doi = {10.1002/advs.202503408}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e03408}, shortjournal = {Adv. Sci.}, title = {SENP6 maintains mitochondrial homeostasis by regulating mitochondrial protein import through deSUMOylation of TOM40}, volume = {12}, year = {2025}, }
• (2025). Controlled growth of graphene-skinned Al2O3 powders by fluidized bed-chemical vapor deposition for heat dissipation. ADVS, 12(40), e03388. (www)

  @article{ , abstract = {The growing demand for high-performance chips, driven by digitalization and intelligence advancements, is accompanied by rising power consumption, highlighting the critical need for efficient thermal management in electronics. Graphene and its composites, characterized by their exceptional thermal conductivity, hold a distinctive position in this domain. The controlled synthesis of high-quality multilayer graphene composites, however, remains a significant challenge, hindering the full utilization of graphene's exceptional thermal conductivity. In this research, we present a breakthrough synthesis strategy for graphene-skinned alumina (Al 2 O 3 ) composites via fluidized bed-chemical vapor deposition (FB-CVD), constructing a continuous graphene skin with high crystallinity with superior reproducibility between batches. This unique structure enhances thermal conductivity and overall performance by leveraging graphene's superior surface characteristics, interlayer thermal properties, and strong phonon coupling with Al 2 O 3 . The heat flow within the graphene skin surpasses that within the Al 2 O 3 powders by more than an order of magnitude, establishing a comprehensive heat transfer network in the composite system. The derived thermal interface materials achieve an exceptional thermal conductivity of 6.44 W·m −1 ·K −1 and reduce hotspot temperatures in micro-LEDs by 17.7 °C. This research established a scalable platform for the synthesis of graphene-skinned ceramic composites, representing a paradigm shift in thermal management strategies for next-generation nanoelectronics.}, archive = {J_ADVS}, author = {Yuzhu Wu and Zhifeng Sun and Ningning Liu and Zhong Wang and Yueming Hu and Tianqi Bai and Tao Wang and Jingyang Chen and Xiaopan Qiu and Xudong Zhang and Fushun Liang and Dongcheng Jiao and Dan Li and Lishuo Han and Wenhu Wang and Qin Xie and Ronghua Zhang and Ali Cai and Yuqi Xia and Haonan Zhai and Zhong-zhen Yu and Yue Qi and Chu Wang and Peng Gao and Xiucai Sun and Bingyang Cao and Yuqing Song and Zhongfan Liu}, doi = {10.1002/advs.202503388}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e03388}, shortjournal = {Adv. Sci.}, title = {Controlled growth of graphene-skinned Al2O3 powders by fluidized bed-chemical vapor deposition for heat dissipation}, volume = {12}, year = {2025}, }
• (2025). Ultrasound-mediated biotransfection of engineered bone marrow mesenchymal stem cells in treated bone defects through intracellular cavitation. ADVS, 12(40), e03196. (www)

  @article{ , abstract = {The lack of stem cells and difficulty in osteogenic differentiation are the primary challenges to treating bone defects. Stem cell gene therapy can efficiently replenish the number of stem cells and facilitate bone differentiation, but its security and efficacy remain challenging. The traditional ultrasound-targeted microbubble destruction (UTMD) technology with extracellular cavitation for gene transfection is safe but inefficient. Consequently, gas vesicles extracted from Halobacterium NRC-1 are used as carriers, incorporating nuclear localization signal, polyethyleneimine, and plasmid bone morphogenetic protein 2 (pBMP2). Then followed by internalization into bone marrow mesenchymal stem cells (BMSCs) to produce engineered BMSCs, which exhibit significant capacity of lysosome escape and nuclear targeting. The permeability of the nuclear membrane is substantially enhanced by low-intensity pulsed ultrasound through intracellular cavitation, thereby increasing plasmid nuclear translocation efficiency and gene transfection efficiency by 284.7% and 131.6%, respectively, compared to conventional UTMD techniques. Besides, the expression of BMP2 is maintained for 21 days, promoting osteogenic differentiation of BMSCs and enhancing bone defect repair. In conclusion, this study provides a more secure, efficient, and regulated approach to BMSCs gene therapy for bone defects.}, archive = {J_ADVS}, author = {Zhili Xu and Huijuan Xin and Yu Wang and Renhao Xu and Yanni He and Meijun Zhou and Zhengqiang Yuan and Hongmei Liu}, doi = {10.1002/advs.202503196}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e03196}, shortjournal = {Adv. Sci.}, title = {Ultrasound-mediated biotransfection of engineered bone marrow mesenchymal stem cells in treated bone defects through intracellular cavitation}, volume = {12}, year = {2025}, }
• (2025). Inhibition of RNase to attenuate fungal-manipulated rhizosphere microbiome and diseases. ADVS, 12(40), e03146. (www)

  @article{ , abstract = {Soil-borne pathogens must cross the barriers of plant-associated microbiota to cause disease. Phytopathogens utilize effector proteins to manipulate host immunity and promote niche colonization. Identifying core effectors involved in both pathogen-microbiota and pathogen-host interactions is vital for understanding pathogenic mechanisms and designing targeted chemical compounds for disease prevention. Here, this work shows that the soil-borne pathogen Fusarium graminearum can manipulate the plant-associated rhizosphere microbiome through the virulence effector Fg12, which encodes a fungal-specific ribonuclease (RNase). Fg12 is widely distributed among various fungal pathogens, and its antibacterial function relies on RNase activity. Several Fg12-inhibited bacterial strains, both individually and in synthetic communities (Syncoms), can alleviate Fusarium infection in soybean and alfalfa plants. Moreover, this work employs structural modeling, molecular docking, and in vitro enzymatic assays to demonstrate that guanosine monophosphate (GMP) functions as an effective chemical inhibitor of Fg12. Notably, GMP efficiently inhibits the antibacterial activity of Fg12 and alleviates disease symptoms in soybean and alfalfa. In conclusion, this work demonstrates that a virulence effector of a fungal phytopathogen can interfere with the host microbiome and propose GMP as a promising RNase inhibitor for attenuating plant fungal diseases.}, archive = {J_ADVS}, author = {Bo Yang and Sen Yang and Xiaomi Wang and Yuanwei Zhang and Yao Zhao and Menghuan Tao and Jinyi Zhu and Wanxin Zhang and Yansu Wang and Kaixuan Duan and Yan Wang and Wenwu Ye and Zhenfei Guo and Yuanchao Wang}, doi = {10.1002/advs.202503146}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e03146}, shortjournal = {Adv. Sci.}, title = {Inhibition of RNase to attenuate fungal-manipulated rhizosphere microbiome and diseases}, volume = {12}, year = {2025}, }
• (2025). USP45 represses melanoma development by deubiquitinating and stabilizing tumor suppressor MRGPRF. ADVS, 12(40), e03106. (www)

  @article{ , abstract = {Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway. However, the regulation of MRGPRF in melanoma remains unclear. Here, 40 ubiquitin-specific proteases (USPs) are screened and USP45 is identified as a significant stabilizer of MRGPRF. Immunohistochemistry on melanoma patient biopsies demonstrates that USP45 expression is markedly reduced in melanoma tissues compared to adjacent noncancerous epidermis. Bioinformatic analyses corroborate that USP45 mRNA levels are downregulated in melanoma, and low USP45 expression is associated with poor patient prognosis. Functional assays demonstrate that USP45 overexpression inhibits melanoma cell malignancy, whereas USP45 knockdown promotes it. Mechanistically, USP45's catalytic domain directly binds to the N-terminal of MRGPRF and stabilizes MRGPRF, likely by removing its K63-linked ubiquitination in melanoma cells. The antimelanoma effects of USP45 are mitigated by MRGPRF depletion, while MRGPRF overexpression rescues the enhanced malignant phenotype induced by USP45 deficiency. In vivo, a melanoma xenograft mouse model shows that USP45 overexpression significantly impairs melanoma progression. These findings establish USP45 as a melanoma suppressor, at least partially through its stabilization of MRGPRF, highlighting a novel mechanism in melanoma pathogenesis and suggesting that USP45 agonists may serve as potential therapeutic agents.}, archive = {J_ADVS}, author = {Wancong Zhang and Liyun Chen and Jing Zhao and Aiwei Ma and Wenqi Shi and Yiwen Zhang and Zixuan Tang and Jiarui Guo and Zaihua Xu and Jianda Zhou and Shijie Tang}, doi = {10.1002/advs.202503106}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e03106}, shortjournal = {Adv. Sci.}, title = {USP45 represses melanoma development by deubiquitinating and stabilizing tumor suppressor MRGPRF}, volume = {12}, year = {2025}, }
• (2025). A nanomodulator enhances radiotherapy-induced in situ cancer vaccine by promoting antigen-presenting of tumor-associated macrophage. ADVS, 12(40), e02876. (www)

  @article{ , abstract = {Radiotherapy (RT) can induce an in situ vaccine effect by promoting the generation of tumor neoantigens, yet this effect is insufficient to elicit robust antitumor immune responses. Although the abundant tumor-associated macrophages (TAMs) in tumor tissue, as members of antigen-presenting cells, have been shown to capture antigens efficiently, the proteomic analysis, that TAMs is demonstrated exhibit up-regulated cysteine protease in lysosomes that leads to tumor antigen degradation. Inhibiting cysteine protease activity can promote the antigen-presenting of TAMs. Based on this, a nanomodulator (Ft-E64/Hf@Lipo) is developed, combining radiosensitizer hafnium (Hf) and the cysteine protease inhibitor E64, which cooperatively reinvigorated the antigen presentation of TAMs. Ft-E64/Hf@Lipo sensitized RT generated abundant tumor neoantigens, and then E64/antigens, along with the apoptotic tumor cells, trafficked to TAMs via efferocytosis. The reprogrammed TAMs with attenuated lysosomal function effectively presented tumor antigens and activated CD8 + T cells. In vivo studies demonstrated that the nanomodulator significantly enhanced systemic antitumor immune responses following RT, realizing excellent therapeutic efficacy against large, treatment-resistant CT26 tumors in combination with anti-PD-1 therapy. The work provides a promising approach for enhancing the in situ vaccine effect of RT to improve its clinical benefits.}, archive = {J_ADVS}, author = {Xiu Zhao and Mengli Li and Jun Li and Yueying Han and Yu Gong and Zhenzhong Zhang and Jinjin Shi and Cheng-Yun Jin and Junjie Liu and Pilei Si}, doi = {10.1002/advs.202502876}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e02876}, shortjournal = {Adv. Sci.}, title = {A nanomodulator enhances radiotherapy-induced in situ cancer vaccine by promoting antigen-presenting of tumor-associated macrophage}, volume = {12}, year = {2025}, }
• (2025). Mesencephalic astrocyte-derived neurotrophic factor binds BAX to preserve mitochondrial homeostasis and energy metabolism for relieving myocardial hypertrophy. ADVS, 12(40), e02835. (www)

  @article{ , abstract = {Myocardial hypertrophy (MH) is a heart disease accompanied by mitochondrial energy disorder and oxidative stress for cardiomyocyte apoptosis. Mesencephalic astrocyte-derived neurotrophic factor (MANF), with anti-inflammation and cytoprotection, is found to be negatively correlated with atrial apoptosis and fibrillation. Here, the effect and mechanism of MANF on MH are studied. Myocardial cell-specific MANF knockout (MKO) mice are constructed to establish transverse aortic constriction (TAC) or angiotensin II (Ang II)-induced MH model. MANF is found to be upregulated by MH and protects cardiomyocytes against TAC or Ang II-induced MH. Mechanistically, through single-cell RNA sequencing and metabolomics analysis, MANF in cardiomyocytes is closely involved in glycolysis-oxidative phosphorylation balance and mitochondrial homeostasis. Furthermore, MANF interacts with pro-apoptotic BAX to inhibit BAX mitochondrial translocation, subsequently decreasing mitochondrial damage, cytochrome c release, and cardiomyocyte death. These results indicate a promising clinical value of MANF for MH treatment, and also preliminarily define MANF's role in mitochondrial energy production and mitochondria-associated apoptosis pathway.}, archive = {J_ADVS}, author = {Dong Wang and Xinru Zhang and Baolong Wang and Haipeng Li and Dongshuo Xu and Yun Yang and Jialu Zhang and Wenbing Wang and Ren Zhang and Xinyu Wang and Yunfeng Cai and Shiyu Cao and Chao Hou and Changhui Wang}, doi = {10.1002/advs.202502835}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e02835}, shortjournal = {Adv. Sci.}, title = {Mesencephalic astrocyte-derived neurotrophic factor binds BAX to preserve mitochondrial homeostasis and energy metabolism for relieving myocardial hypertrophy}, volume = {12}, year = {2025}, }
• (2025). Quantitative control of oxygen non-stoichiometry and negative raman chemical shift during topotactic phase transition in a ca-doped BiFeO3 thin-film. ADVS, 12(40), e02439. (www)

  @article{ , abstract = {Controlling the non-stoichiometry is an effective way to tune physicochemical properties of functional oxides and explore novel physical phenomena in complex oxides. Therefore, quantitative control of oxygen non-stoichiometry in perovskite oxides plays an important role in understanding the mechanism of topotactic phase transition and improving the applicability of electrochemical devices. Here, an electrochemical titration cell is fabricated to control the oxygen non-stoichiometry of a Bi 0.4 Ca 0.6 FeO 3- δ thin film grown on yttria-stabilized zirconia substrate. The amount of oxygen pumped into the thin film depending on the applied voltage is quantitatively determined through chronoamperometry measurements. Non-monotonic changes in lattice parameters are observed using X-ray diffraction. Considerable negative Raman chemical shifts have occurred even in the range of small applied voltages that result in little changes in the non-stoichiometry or average lattice parameters. These observations on chemo-mechanical coupling can be interpreted as characteristics of vacancy-ordered perovskite oxides. This work offers useful insights into the mechanism of topotactic phase transition in perovskite oxides.}, archive = {J_ADVS}, author = {Heung-Sik Park and Semin Cheon and Yong-Jun Kwon and Minho Kang and Jeonghun Suh and Sang-Youn Park and Yongsoo Yang and Chan-Ho Yang}, doi = {10.1002/advs.202502439}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e02439}, shortjournal = {Adv. Sci.}, title = {Quantitative control of oxygen non-stoichiometry and negative raman chemical shift during topotactic phase transition in a ca-doped BiFeO3 thin-film}, volume = {12}, year = {2025}, }
• (2025). Developmental hypoxia enhances kidney organoid complexity and maturity. ADVS, 12(40), e01661. (www)

  @article{ , abstract = {Reciprocal signaling between metanephric mesenchyme (MM) and ureteric bud (UB) is essential for human kidney development. However, human pluripotent stem cell-derived kidney organoids do not incorporate UB differentiation, limiting organoid maturation and disease modeling. Here, a hypoxia-based differentiation method inspired by developmental cues is reported that produces mature kidney organoids with collecting duct-like tubules connected to multiple nephrons. Hypoxia promotes the co-induction of MM and UB-like progenitors within the same culture dish. The augmented expression of reciprocal signaling genes guides the differentiation of the kidney organoids into highly structured tubular networks, mature RNA profiles, and a more realistic micro-anatomy, leading to higher-order kidney organogenesis in vitro. These hypoxia-enhanced kidney organoids recapitulate the cystic phenotype in polycystic kidney disease, displaying efficient cyst formation across the entire tubular region and increased sensitivity to drugs. The findings provide an improved in vitro model for studying kidney development and disease mechanisms.}, archive = {J_ADVS}, author = {Hyeonji Lim and Dohui Kim and Haejin Yoon and Joo H. Kang and Yong Jun Kim and Dong Sung Kim and Tae-Eun Park}, doi = {10.1002/advs.202501661}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e01661}, shortjournal = {Adv. Sci.}, title = {Developmental hypoxia enhances kidney organoid complexity and maturity}, volume = {12}, year = {2025}, }
• (2025). Nrf2 drives epigenetic reprogramming and acts as the master regulator of KLF4 expression and activity in arsenic-induced transformation. ADVS, 12(40), e00221. (www)

  @article{ , abstract = {Emerging evidence suggests that Nrf2 plays a pro-carcinogenic role in multiple cancers. Previous studies have shown that arsenic-induced Nrf2 activation drives metabolic reprogramming, leading to the formation of cancer stem-like cells. Here, we further demonstrate that KLF4, a key pluripotency factor, is a direct transcriptional target of Nrf2 in arsenic-treated human bronchial epithelial cells (BEAS-2B). Global chromatin immunoprecipitation sequencing (ChIP-seq) revealed multiple Nrf2 binding peaks within the KLF4 locus, overlapping with the enhancer markers H3K4me1 and H3K27Ac. Nrf2 knockout diminished KLF4 expression and reduced enhancer marker enrichment, accompanied by a global decrease in KLF4 genomic occupancy in BEAS-2B cells. Additionally, arsenic exposure enhances KLF4 binding at genes implicated in oncogenic pathways, including STAT3, SOX2, Nrf2 itself, cell growth regulators, Hedgehog signaling components, and epithelial-to-mesenchymal transition (EMT) markers. Notably, we identified a self-reinforcing feedback loop between Nrf2 and KLF4 that amplifies their oncogenic effects. Finally, our data reveal that Nrf2-KLF4 co-occupancy is essential for establishing active enhancer hubs across the genome. Collectively, these findings suggest that Nrf2's oncogenic effects are, in part, mediated through the Nrf2-dependent amplification of KLF4 expression and function. Targeting both Nrf2 and KLF4 may, therefore, represent a promising therapeutic strategy to eliminate arsenic-induced cancer stem-like cells.}, archive = {J_ADVS}, author = {Ziwei Wang and Zhuoyue Bi and Jessica Bamrah and Yiran Qiu and Wenxuan Zhang and Bandar Saeed Almutairy and Haoyan Ji and John D. Haley and Chitra Thakur and Fei Chen}, doi = {10.1002/advs.202500221}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e00221}, shortjournal = {Adv. Sci.}, title = {Nrf2 drives epigenetic reprogramming and acts as the master regulator of KLF4 expression and activity in arsenic-induced transformation}, volume = {12}, year = {2025}, }
• (2025). A mass spectrometry approach reveals fatty acid isomerism in tomato cold tolerance. ADVS, 12(40), e00175. (www)

  @article{ , abstract = {Plants can adapt to environmental fluctuations through modulating their fatty acids (FAs) dynamically. In this study, an enhanced mass spectrometry approach is utilized to uncover an unexplored landscape of FAs and FA isomers that are critical for cold tolerance in tomato. This technology integrates N-(4-aminomethylphenyl) pyridium derivatization of FAs, charge-tagging Paternò-Büchi (PB) photochemical reaction to identify carbon–carbon double bond (C═C) positions and reversed-phase liquid chromatography coupled with tandem mass spectrometry to achieve efficient detection of FAs and their C═C location isomers. Several saturated FAs, unsaturated FAs and their C═C location isomers are revealed to contribute to the cold tolerance of elongated hypocotyl 5 ( slhy5 ) and fatty acid desaturase ( slfad ) mutant plants. RNA-sequencing analysis and dual-luciferase reporter assays further demonstrate that Sl HY5 can modulate the expression of Sl FAD2 genes under cold stress, regulating FA desaturation. The application of FA isomers to the leaves of slfad mutants partially rescues their cold sensitivity, presenting the practical implications of the study. The study thereby highlights the importance of considering isomeric variations in FAs when investigating plant physiology and stress responses. Furthermore, this methodology sets a valuable precedent for future investigations aimed at unraveling the intricate metabolic networks that govern plant stress adaptation.}, archive = {J_ADVS}, author = {Leelyn Chong and Hengxue Shi and Qirui Yu and Xiaoning Shi and Zhaoxing Jia and Ziyun Dong and Yu Xia and Yingfang Zhu}, doi = {10.1002/advs.202500175}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {e00175}, shortjournal = {Adv. Sci.}, title = {A mass spectrometry approach reveals fatty acid isomerism in tomato cold tolerance}, volume = {12}, year = {2025}, }
• (2025). Establishment of “Structure-efficiency” relationship in ultra-high purity metal systems: Multi-scale analysis of tellurium as a prototype (Adv. sci. 40/2025). ADVS, 12(40), 71965. (www)

  @article{ , archive = {J_ADVS}, author = {Shuai Guo and Xianglei Dong and Lin Zheng and Ming Gao and Guoqin Cao and Ping Peng and Jilin He and Junhua Hu}, doi = {10.1002/advs.71965}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {71965}, shortjournal = {Adv. Sci.}, title = {Establishment of “Structure-efficiency” relationship in ultra-high purity metal systems: Multi-scale analysis of tellurium as a prototype (Adv. sci. 40/2025)}, volume = {12}, year = {2025}, }
• (2025). Bioinspired brush reinforced solid slippery coatings for marine photovoltaic protection (Adv. sci. 40/2025). ADVS, 12(40), 71960. (www)

  @article{ , archive = {J_ADVS}, author = {Ling Yin and Runxiang Tan and Junyi Han and Jianing Wang and Jianjun Cheng and Daheng Wu and Tao Zhang and Liping Wang}, doi = {10.1002/advs.71960}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {71960}, shortjournal = {Adv. Sci.}, title = {Bioinspired brush reinforced solid slippery coatings for marine photovoltaic protection (Adv. sci. 40/2025)}, volume = {12}, year = {2025}, }
• (2025). A wearable electrochemical biosensor for salivary detection of periodontal inflammation biomarkers: Molecularly imprinted polymer sensor with deep learning integration (Adv. sci. 40/2025). ADVS, 12(40), 71959. (www)

  @article{ , archive = {J_ADVS}, author = {Sangheon Jeon and Sung Hyun Kim and Gyeonghwa Heo and Hye Jin Heo and Seon Yeong Chae and Young Woo Kwon and Shin-Kyu Lee and Dong-Wook Han and Hyun-Joo Kim and Yun Hak Kim and Suck Won Hong}, doi = {10.1002/advs.71959}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {71959}, shortjournal = {Adv. Sci.}, title = {A wearable electrochemical biosensor for salivary detection of periodontal inflammation biomarkers: Molecularly imprinted polymer sensor with deep learning integration (Adv. sci. 40/2025)}, volume = {12}, year = {2025}, }
• (2025). Hologenomics reveals specialized dietary adaptations in the mengla snail-eating snake (Adv. sci. 40/2025). ADVS, 12(40), 71958. (www)

  @article{ , archive = {J_ADVS}, author = {Chaochao Yan and Xin-Ning Li and Zhong-Liang Peng and Wei Wu and Zeng Wang and Zhao-Ran Zhu and Jia-Chang Liu and Yao Wang and Jin-Long Ren and Zhi-Yi Zhang and Jia-Tang Li}, doi = {10.1002/advs.71958}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {71958}, shortjournal = {Adv. Sci.}, title = {Hologenomics reveals specialized dietary adaptations in the mengla snail-eating snake (Adv. sci. 40/2025)}, volume = {12}, year = {2025}, }
• (2025). Lenvatinib plus paclitaxel as second-line therapy for advanced gastric cancer patients: A dose escalation exploratory study (Adv. sci. 40/2025). ADVS, 12(40), 71957. (www)

  @article{ , archive = {J_ADVS}, author = {Chenfei Zhou and Jinling Jiang and Liting Guo and Wenqi Xi and Junwei Wu and Qu Cai and Jun Ji and Feng Qi and Jun Zhang}, doi = {10.1002/advs.71957}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {71957}, shortjournal = {Adv. Sci.}, title = {Lenvatinib plus paclitaxel as second-line therapy for advanced gastric cancer patients: A dose escalation exploratory study (Adv. sci. 40/2025)}, volume = {12}, year = {2025}, }
• (2025). Adaptive mechanical metamaterials with on-demand binary local modulus for embodied intelligence (Adv. sci. 40/2025). ADVS, 12(40), 71955. (www)

  @article{ , archive = {J_ADVS}, author = {Richard J. Nash and Yunzheng Yang and Yaning Li}, doi = {10.1002/advs.71955}, journal = {Advanced Science}, month = {10}, number = {40}, pages = {71955}, shortjournal = {Adv. Sci.}, title = {Adaptive mechanical metamaterials with on-demand binary local modulus for embodied intelligence (Adv. sci. 40/2025)}, volume = {12}, year = {2025}, }
• (2025). Single-cell RNA sequencing reveals the heterogeneity in differentiation trajectory and tumor microenvironment leading to more aggressive phenotypes of papillary thyroid cancer in children and young adult patients. ADVS, 12(39), e17672. (www)

  @article{ , abstract = {The tumor ecosystem heterogeneity of papillary thyroid carcinoma (PTC) is poorly characterized in children and young adult patients (CAYA-PTC). In this study, single-cell RNA sequencing is used to profile transcriptomes from the paratumor and tumor tissues of 11 patients. Compared to adult, CD4T_Tfh and CD8T_Tex cells are significantly more prevalent in CAYA-PTC patients. Three phenotypes are identified within the thyrocytes through differentiation trajectory analysis, including normal, BRAF-like, and Fusion-like. Notably, the data reveal that CAYA-PTC patients lack the “mild-state (BRAF-like)” malignant thyrocyte population. This variation in differentiation states indicates that PTC cells in CAYA patients rapidly develop into invasive and metastatic forms, whereas in adult patients, this progression occurs gradually over a longer period. Additionally, extracellular matrix cancer-associated fibroblasts (emCAFs_LAMP5) interact with endothelial cells and thyrocytes, promoting tumor angiogenesis and metastasis more prominently in CAYA patients. Fibroblast activation protein (FAP) expression is high in emCAF_LAMP5 and positively correlated with LAMP5 in CAYA-PTC tissues. Consequently, 68Ga-FAPI-PET emerges as a promising diagnostic method for CAYA patients who are not effectively diagnosed by traditional 18F-FDG-PET. Collectively, the findings provide insight into the CAYA-PTC ecosystem that suggests distinct diagnostic, prognostic, and therapeutic implications compared to adults.}, archive = {J_ADVS}, author = {Kai Guo and Lingyi Yang and Zirui Huang and Kai Qian and Yuan Shi and Mengjia Fei and Yuan Feng and Zixian Chen and Ming Qiu and Linglin Tang and Anqi Li and Zhibao Lv and Jiangbin Liu and Zhou Chen and Kuiran Dong and Zhuoying Wang}, doi = {10.1002/advs.202417672}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e17672}, shortjournal = {Adv. Sci.}, title = {Single-cell RNA sequencing reveals the heterogeneity in differentiation trajectory and tumor microenvironment leading to more aggressive phenotypes of papillary thyroid cancer in children and young adult patients}, volume = {12}, year = {2025}, }
• (2025). Restoration of SIRT3 expression in aged mice alleviates UUO-induced renal fibrosis by reducing GSK-3β hyperacetylation. ADVS, 12(39), e17248. (www)

  @article{ , abstract = {Aging increases the vulnerability of kidneys to injury and impairs their regenerative capacity. SIRT3 expression declines with aging and is associated with multiple age-related pathologies. The expression profile and functional role of SIRT3 in renal aging remain unclear. Here, SIRT3 expression in aging kidneys is assessed and analyzed for its promoter methylation patterns using methylation-specific PCR (MSP). It is found that aging exacerbates UUO-induced renal fibrosis, associated with downregulated SIRT3 expression. Mechanistically, age-related SIRT3 downregulation is mediated by hypermethylation of its promoter region. SIRT3 knockout exacerbated renal fibrosis in young mice subjected to UUO, whereas SIRT3 overexpression attenuated fibrosis in aged UUO mice. Integration of RNA-seq and immunoprecipitation-mass spectrometry (IP-MS) analyses revealed that SIRT3 deficiency leads to hyperacetylation of GSK3β at lysine 15 (K15). This K15 hyperacetylation inhibited GSK3β activity, consequently stabilizing its substrate β-catenin. Furthermore, self-assembled PEG-PCL-PEG micelles are designed and synthesized to encapsulate hydrophobic honokiol (HKL). These micelles significantly enhanced the aqueous solubility and oral bioavailability of free HKL, maintained stable blood concentrations, and ultimately improved its anti-fibrotic efficacy. These findings propose novel therapeutic strategies for managing renal fibrosis in the aging population and provide a foundation for developing new drugs and combination therapies.}, archive = {J_ADVS}, author = {Jing Wang and Xiang Ren and Huan Lu and Zihao Guo and Xing Li and Yiqun Tian and Yisheng Yin and Zhenliang Qin and Kun Yun and Minglong Wu and Gang Chen and Xiaoyong Zeng}, doi = {10.1002/advs.202417248}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e17248}, shortjournal = {Adv. Sci.}, title = {Restoration of SIRT3 expression in aged mice alleviates UUO-induced renal fibrosis by reducing GSK-3β hyperacetylation}, volume = {12}, year = {2025}, }
• (2025). Role of SLC16A10 in psoriasis through the regulation of arachidonic acid metabolism in keratinocytes. ADVS, 12(39), e17093. (www)

  @article{ , abstract = {Psoriasis is an inflammatory dermatological condition challenging to treat and prone to recurrence. The pathogenesis of psoriasis is closely associated with metabolic disorders, while therapies targeting the dysregulated metabolism in psoriasis remain limited. Therefore, exploring the pathogenesis of psoriasis and identifying potential metabolic therapeutic targets is imperative. In this study, potential biomarkers for clinically targeted metabolic therapies in patients with psoriasis are aimed to be identified. RNA-sequencing analysis is performed on metabolism-related genes to identify differentially expressed metabolism-related genes. Then, various bioinformatics analyses and comprehensive functional experiments are conducted to verify the roles of the identified genes. A key gene SLC16A10 is identified with significant diagnostic and therapeutic potential for psoriasis. SLC16A10 is likely involved in arachidonic acid metabolism in keratinocytes through regulating thyroid hormone homeostasis, contributing to the development of psoriasis. SLC16A10 represents a promising therapeutic target for guttate psoriasis and can improve the outcomes of existing immune-targeted therapeutic agents. Comprehensive in vitro and in vivo experiments confirm that SLC16A10 downregulation alleviates the severity of psoriasis and hyperinflammation. Moreover, SLC16A10 may induce one of the sequelae of psoriasis, namely post-inflammatory hypopigmentation, by inhibiting melanogenesis. These findings demonstrate the potential of SLC16A10 as a diagnostic biomarker and therapeutic target for psoriasis.}, archive = {J_ADVS}, author = {Jingyuan Yang and Yixuan Chen and Bowei Li and Shuang Wu and Hang Liang and Xingyue Yang and Xiaozhen Li and Ping Sun and Guangjin Guo and Ting Li and Yuying Jia and Haijiao Li and Mengqi Bai and Jie Xu and Zhijie Liu and Wei Liu and Xiangkang Jiang and Hong Cai}, doi = {10.1002/advs.202417093}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e17093}, shortjournal = {Adv. Sci.}, title = {Role of SLC16A10 in psoriasis through the regulation of arachidonic acid metabolism in keratinocytes}, volume = {12}, year = {2025}, }
• (2025). Activation of lysosomal retrograde transport triggers TPC1-IP3R1 ca2+ crosstalk at lysosome-ER MCSs leading to lethal depleting of ER calcium. ADVS, 12(39), e15313. (www)

  @article{ , abstract = {Inter-organellar signaling linkages in oncology are increasingly elucidated. However, the impact of lysosome-endoplasmic reticulum (ER) interaction on tumor cell fate remains relatively unexplored. A novel interaction between lysosomes and the ER, mediated by the flavonoid LW-213 through targeting LIMP2 (lysosomal integral membrane protein type 2)to activate a lysosomal repair pathway, is identified in acute myeloid leukemia (AML). This leads to activated RAB7A activity, enhancing lysosomal retrograde transport to the perinuclear region and increasing contact at lysosome-ER membrane contact sites (MCSs). Close proximity of TPC1 to IP3R1 at these sites generates a concentrated calcium microdomain, triggering Ca 2+ -induced Ca 2+ release, which causes cytoplasmic calcium turbulence and two distinct calcium tides. This excessive calcium efflux depletes ER calcium stores, triggering lethal ER stress-induced apoptosis. Interestingly, altering TPC1 expression levels in HeLa cells affected these calcium dynamics, replicating AML-specific mechanisms when overexpressed. Subsequent studies using BALB/c xenograft models with wild-type and LIMP2-knockout THP1 cells, along with ICR mice toxicity models, confirmed LW-213′s significant tumor growth inhibition with minimal toxicity. These findings underscore the potential of targeting lysosomal-ER calcium crosstalk as an innovative approach to cancer treatment, highlighting the therapeutic promise of LW-213 in managing tumor cell fate through modulating organellar interactions.}, archive = {J_ADVS}, author = {Meng-yuan Zhu and Yong-jian Guo and Yu-qi Zhu and Hong-zheng Wang and Hai-di Wang and Hong-yu Chen and Yue-xin Jiang and Hui Li and Hui Hui}, doi = {10.1002/advs.202415313}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e15313}, shortjournal = {Adv. Sci.}, title = {Activation of lysosomal retrograde transport triggers TPC1-IP3R1 ca2+ crosstalk at lysosome-ER MCSs leading to lethal depleting of ER calcium}, volume = {12}, year = {2025}, }
• (2025). Correction to “Transformation of 3D Metal–Organic frameworks into nanosheets with enhanced memristive behavior for electronic data processing”. ADVS, 12(39), e14348. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202514348}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e14348}, shortjournal = {Adv. Sci.}, title = {Correction to “Transformation of 3D Metal–Organic frameworks into nanosheets with enhanced memristive behavior for electronic data processing”}, volume = {12}, year = {2025}, }
• (2025). Revealing cell-free mitochondrial DNA breakage patterns as novel biomarkers for sepsis. ADVS, 12(39), e14159. (www)

  @article{ , abstract = {Accurate early diagnosis and prognosis of sepsis remain major clinical challenges. This study explores specific plasma cell-free mitochondrial DNA (cfmtDNA) breakage patterns as potential biomarkers for sepsis. Plasma samples from ten non-sepsis control patients and 63 sepsis patients are analyzed using mitochondrial DNA fragmentomics, revealing distinct breakage sites in the RNR2 (positions 2474–2478) and COX2 (positions 7761, 7775, 7776, 7777, and 7783) regions, which are intact in healthy individuals but exhibited high-frequency breakage in sepsis patients. Diagnostic models based on these breakage sites show superior accuracy for sepsis detection (AUC = 0.865) and prognosis prediction (AUC = 0.809) compared to traditional cfmtDNA copy number assessments. Notably, COX2 breakage frequency correlated with inflammatory markers and SOFA scores, highlighting its prognostic potential. Mechanistic analyses suggest that reduced protein binding in sepsis may increase cfmtDNA susceptibility to cleavage by bacterial restriction endonucleases. These findings indicate that plasma cfmtDNA breakage characteristics can serve as valuable biomarkers for early sepsis detection and therapeutic monitoring.}, archive = {J_ADVS}, author = {Haitang Liao and Ruiyan Ma and Shuai Hao and Xuxin Tan and Xue Zeng and Rui Song and Bing Chen and Zhezhe Cao and Wei Shen and Zhenchun Luo and Jianfeng Huang and He Huang and Liangming Liu and Chenyang Duan}, doi = {10.1002/advs.202414159}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e14159}, shortjournal = {Adv. Sci.}, title = {Revealing cell-free mitochondrial DNA breakage patterns as novel biomarkers for sepsis}, volume = {12}, year = {2025}, }
• (2025). Rational design and fabrication of MEMS gas sensors with long-term stability: A comprehensive review. ADVS, 12(39), e11555. (www)

  @article{ , abstract = {With the growing demand for chemical information collection from the environment, miniaturized size and high sensitivity labeled microelectromechanical systems (MEMS) gas molecular sensing devices have emerged as a promising element in the development of machine olfactory. However, prolonged exposure to gas analytes often induces slow chemical transformations on the sensing film surface, leading to reduced chemical activity, performance degradation, and mechanical failures such as membrane cracking or delamination. In the real market, especially under harsh working environments, long-term stability is a critical quality metric in gas sensor development. Therefore, the pursuit of MEMS gas sensors that offer both high sensitivity and extended lifespan becomes indispensable yet challenging. Thus, this review provides a comprehensive overview of recent studies and achievements in MEMS gas sensors, highlighting efforts aimed at enhancing their working stability. Key areas of focus include advancements in the chemical and physical characteristics of sensing films, as well as improvements in device structures. Furthermore, current limitations, perspectives, and future possibilities for designing and fabricating MEMS gas sensors with long-term stability are discussed.}, archive = {J_ADVS}, author = {Chao Zhang and Tianyi Wang and Guozhu Zhang and Rui Gao and Chengze Gao and Zeyu Wang and Fuzhen Xuan}, doi = {10.1002/advs.202511555}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e11555}, shortjournal = {Adv. Sci.}, title = {Rational design and fabrication of MEMS gas sensors with long-term stability: A comprehensive review}, volume = {12}, year = {2025}, }
• (2025). DNA-based hydrogels for musculoskeletal reconstruction: Harnessing dynamic programmability and multimodal therapeutic integration. ADVS, 12(39), e11099. (www)

  @article{ , abstract = {Musculoskeletal disorders, including bone fractures, osteoarthritis, and muscle injuries, represent a leading cause of global disability, revealing the urgency for advanced therapeutic solutions. However, current therapies face limitations including donor-site morbidity, immune rejection, and inadequate mimicry of dynamic tissue repair processes. DNA-based hydrogels emerge as transformative platforms for musculoskeletal reconstruction, with their sequence programmability, dynamic adaptability, and biocompatibility to balance structural support and biological functions. These hydrogels are classified into two categories: 1) DNA hydrogels, where DNA serves as the structural backbone; 2) DNA component-loaded hydrogels, integrating functional DNA elements like aptamers and therapeutic genes into non-DNA matrices. Through dynamic crosslinking strategies, primarily Watson-Crick base pairing, DNA networks achieve shear-thinning injectability and self-healing behaviors while providing binding sites for bioactive DNA components. Hybrid systems further enhance functionality by incorporating diverse materials to improve mechanical strength, drug delivery, and cellular guidance. This review systematically examines molecular design principles, classification frameworks, and preclinical applications of DNA-based hydrogels, aiming to bridge gaps between material innovation and clinical translation. Finally, current challenges are highlighted, and future directions to advance these intelligent biomaterials toward next-generation musculoskeletal therapies are proposed.}, archive = {J_ADVS}, author = {Ruijianghan Shi and Huilu Zhan and Shan Jiang and Kaili Lin and Changyong Yuan}, doi = {10.1002/advs.202511099}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e11099}, shortjournal = {Adv. Sci.}, title = {DNA-based hydrogels for musculoskeletal reconstruction: Harnessing dynamic programmability and multimodal therapeutic integration}, volume = {12}, year = {2025}, }
• (2025). Synergy between defects and lattice distortion drives self-powered elastico-near-infrared mechanoluminescence in cr3+-doped spinel oxides. ADVS, 12(39), e10848. (www)

  @article{ , abstract = {Elastico-mechanoluminescence (ML) enables unique force-to-light transduction for applications in human-machine interaction and smart sensing, yet traditional trap-controlled models fail to explain self-powered ML phenomena. Here, a Cr 3+ -doped spinel oxide exhibiting autonomous near-infrared (NIR) ML is reported, where self-powered emission originates from synergistic interactions between local lattice distortions and multi-defect networks. Theoretical calculations reveal that Cr 3+ doping activates nearest-neighbor sites to generate mid-gap states, facilitating stress-driven electron tunneling to luminescent centers without external excitation. The material shows narrowband NIR emission (711 nm) from the spin-forbidden transition, with linear ML intensity response to mechanical stress and negligible persistent luminescence. Proof-of-concept demonstrations in bright-field anti-counterfeiting (NIR QR-code imaging) and biomedical tissue penetration (10 mm pork) validate its practical utility. This work establishes a defect-distortion coupling mechanism for self-powered NIR-ML, providing a theoretical framework to guide the design of next-generation autonomous optomechanical materials for energy-efficient sensing and bio-imaging.}, archive = {J_ADVS}, author = {Yao Xiao and Kang Chen and Mingzi Sun and Puxian Xiong and Bolong Huang and Yongsheng Sun and Dongdan Chen and Jiulin Gan and Zhongmin Yang}, doi = {10.1002/advs.202510848}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10848}, shortjournal = {Adv. Sci.}, title = {Synergy between defects and lattice distortion drives self-powered elastico-near-infrared mechanoluminescence in cr3+-doped spinel oxides}, volume = {12}, year = {2025}, }
• (2025). A mesoporous calcium peroxide nanocuboid with high tumor accumulation across biological barriers for high efficacy tumor therapy. ADVS, 12(39), e10778. (www)

  @article{ , abstract = {The common problem of tumor therapy based on nanoparticles is the limited efficacy due to the blockage of tumor accumulation by biological barriers. To enhance the drug delivery of nanoparticles across biological barriers and augment their tumor accumulation, herein, a mesoporous calcium peroxide nanocuboid (MCPNC) is developed via a facile hydrolysis-precipitation method, which can be utilized for high efficacy tumor therapy by promoting a positive feedback loop of Fenton reaction. The biodistribution results demonstrate that MCPNC exhibits higher accumulation in various tissues than calcium peroxide nanosphere (CPNS). Ferroheme (FH) and exceedingly small magnetic iron oxide nanoparticle (IO) loaded MCPNC is modified with hyaluronic acid (HA), forming MCPNC-FH-IO@HA. Under acidic tumor microenvironment (TME), Fe 3+/2+ , H 2 O 2 and Ca 2+ can be released from MCPNC-FH-IO@HA. The reactive oxygen species (ROS) generation through Fenton reaction can disrupt mitochondrial membranes, which accelerates the unbalance of Ca 2+ mitochondrial homeostasis. The loss of mitochondrial membrane potential activates mitochondrial autophagy, which results in the release of Fe 3+/2+ in tumor mitochondria. The released Fe 3+/2+ can further produce more and more ROS via the Fenton reaction, which establishes the positive feedback loop of the Fenton reaction. Both in vitro and in vivo results demonstrate that MCPNC-FH-IO@HA exhibits remarkable antitumor efficacy, superior MRI performance, and favorable biosafety.}, archive = {J_ADVS}, author = {Qingdeng Fan and Min Wang and Jie Lin and Ya Huang and Jing Yang and Jiaoyang Zhu and Bin Ren and Li Sun and Zongheng Li and Aochi Liu and Wei Xiong and Zhenni Wei and Lin Huang and Chenggong Yan and Ge Wen and Zhao Chen and Xiaoyuan Chen and Zheyu Shen}, doi = {10.1002/advs.202510778}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10778}, shortjournal = {Adv. Sci.}, title = {A mesoporous calcium peroxide nanocuboid with high tumor accumulation across biological barriers for high efficacy tumor therapy}, volume = {12}, year = {2025}, }
• (2025). Breaking stiffness-tunability trade-offs in metamaterials: A minimal surface guided hybrid lattice strategy. ADVS, 12(39), e10586. (www)

  @article{ , abstract = {A longstanding trade-off between stiffness and tunability has significantly constrained the multifunctional potential of architected metamaterials. Here, a generalizable design framework is introduced that integrates shell- and plate-based lattice architectures via a spatially compensated Boolean fusion strategy. The design enables tunable architectures with optimized mechanical robustness. The capability is demonstrated through two representative configurations: one based on Primitive TPMS and one on IWP TPMS, each fused with simple cubic plate lattices. The resulting structures are fabricated with high geometric fidelity using PolyJet printing and evaluated across multiple scales using homogenization, quasi-static compression testing, and finite element analysis. Compared with similarly ultrastiff plate lattices, the hybrid structure achieves a 213.98% increase in the tunable range of effective elastic modulus. The hybrid lattices reach 137.34% and 110.84% of the Hashin-Shtrikman upper bound for Young's modulus at relative densities of 0.33 and 0.34, respectively. Compared to single lattices, the hybrid designs show significant improvements: ultimate stress increased by up to 690% and specific energy absorption increased by 110%. The proposed metamaterials offer excellent tunability and mechanical performance, providing the flexibility to tailor structural behaviors for diverse applications such as biomedical engineering, acoustic isolation, and intelligent infrastructure systems.}, archive = {J_ADVS}, author = {Min Zhang and Kang Gao and Jinlong Liu and Zhiqiang Zou and Jie Yang and Ma Qian and Wei Zhai and Zhangming Wu}, doi = {10.1002/advs.202510586}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10586}, shortjournal = {Adv. Sci.}, title = {Breaking stiffness-tunability trade-offs in metamaterials: A minimal surface guided hybrid lattice strategy}, volume = {12}, year = {2025}, }
• (2025). Dynamic eIF3-s6 phase separation switch instructed by m6A modification drives the molting of locusts. ADVS, 12(39), e10505. (www)

  @article{ , abstract = {Molting is critical for the development and growth of insects. A central juncture in molting is the periodic and coordinated regulation of molting-responsive mRNAs, which are essential for degrading the old cuticle and forming a new one. Knowledge is lacking of how molting-responsive molecules function cooperatively and timely. Here, multi-stage m 6 A modification levels, m 6 A reader condensation, and transcriptome analyses are developed to track the dynamic functional coupling for molting signals. The results showed that the molting-responsive mRNAs are downregulated with the decrease of m 6 A modification levels from pre-molt to the molt stage. The eIF3-S6 is further identified, as an m 6 A reader, can directly bind to EcR A 335 and Cht10 A 7589 . The low mRNA m 6 A modification in the molt stage facilitates eIF3-S6 to undergo liquid–liquid phase separation (LLPS) by binding m 6 A-containing EcR / Cht10 into condensed droplets for stabilizing the mRNAs. Disruption of m 6 A modification or breaking phase separation can cause a disorder of the new/old cuticle synthesis/degradation in molting. The disorder results in abnormal and unsuccessful molting, ultimately leading to the death of nymphs. Overall, the data mechanistically highlight an example of how two central machineries, m 6 A modification and LLPS, can accurately and functionally cooperate to optimize molting-responsive gene expression for insect molting.}, archive = {J_ADVS}, author = {Zhihao Hu and Yu Zhou and Huimin Wang and Yaxi Wu and Rui Han and Shili Liu and Feng Jiang and Xiaojiao Guo and Meiling Yang}, doi = {10.1002/advs.202510505}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10505}, shortjournal = {Adv. Sci.}, title = {Dynamic eIF3-s6 phase separation switch instructed by m6A modification drives the molting of locusts}, volume = {12}, year = {2025}, }
• (2025). Ultra-low operating voltage memristors based on Plating/Stripping reactions. ADVS, 12(39), e10370. (www)

  @article{ , abstract = {Current memristor technologies remain limited by instability, high operating voltage, and low switching ratio, primarily due to stochastic filament formation and defect migration. Here, a fundamentally different electrochemical mechanism is proposed through the development of a plating/stripping memristor (PSM) featuring stable, low-voltage, and bio-inspired conductance switching. Constructed with Zn/Cu electrodes and a deep eutectic gel electrolyte (DEGE), the PSM accurately emulates spike-rate-dependent plasticity and long-term synaptic dynamics. The DEGE matrix offers a corrosion-resistant, dendrite-free, and ionically homogeneous environment, facilitating gradual and programmable conductance evolution. Remarkably, the Zn/DEGE/Cu PSM exhibits switching behavior with a low-resistance state centered at 15.3 µV and dual high-resistance states at –10.0 mV and +11.1 mV, governed by electrochemical equilibrium, highlighting its sub-millivolt-level operation and energy-efficient switching characteristics. Furthermore, the Zn/DEGE/Cu PSMs are integrated into a reservoir computing framework using 4-bit pulse-encoded conductance states. When applied to pattern recognition tasks, the DEGE-based PSM system demonstrates a reliable classification accuracy of 89.3%, driven by device-derived temporal dynamics. Overall, this study establishes a new materials and mechanistic foundation for energy-efficient neuromorphic computing, bridging electrochemical reactions with biologically plausible information processing.}, archive = {J_ADVS}, author = {Lingbo Yao and Zhurui Wang and Yanyu Sun and Xiaowei Chi and Yu Liu}, doi = {10.1002/advs.202510370}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10370}, shortjournal = {Adv. Sci.}, title = {Ultra-low operating voltage memristors based on Plating/Stripping reactions}, volume = {12}, year = {2025}, }
• (2025). In situ structural evolution and activity descriptor of atomically dispersed catalysts during nitrate electroreduction. ADVS, 12(39), e10282. (www)

  @article{ , abstract = {Single-Atom Catalysts (SAC) have emerged as a promising class of materials for various catalytic applications, including the electrochemical nitrate reduction reaction (eNO 3 RR) and consequently ammonia production. While the efficiency and selectivity of these materials have been extensively highlighted for the eNO 3 RR, the in situ evolution to their structure and composition during electrocatalysis is largely unexplored and lacks catalyst design principles. To solve this, we investigated a series of high utilization metal-nitrogen-carbon (MNC) SACs (M = Cr, Fe, Co, Ni, and Cu) for eNO 3 RR. Except for CuNC, which selectively produced nitrite, all catalysts exhibited Faradaic efficiencies (FE) for ammonia exceeding 50%. NiNC demonstrated the highest performance (FE of 78.0 ± 2.9% at −0.4 V versus reversible hydrogen electrode (RHE) at pH 13 and maximum ammonia production rate of 615.7 ± 176.5 µmol·h −1 · , corresponding to an energy efficiency of 15.1 ± 1.4% at −0.6 V RHE ), followed by CoNC. In situ Synchrotron X-ray fluorescence (SXRF) mapping at various cathodic potentials (from open circuit potential to 0.0 V RHE and then −0.6 V RHE at 100 mV steps) revealed significant mobility of Ni within the carbon matrix, leading to the formation of metallic clusters from 0.0 V RHE . Similar in situ metal clustering is observed for CoNC. Structure-activity plots are generated from both MNC literature and results obtained here, finding a clear trend between OH binding energy and turnover frequency, with the high activity of NiNC and CoNC in this work explained by their stronger OH binding in the metallic structure compared to their SAC coordination. This work therefore, reveals the structure-activity-stability of MNCs for eNO 3 RR and provides a simple descriptor for identifying highly active eNO 3 RR catalysts and their in situ structural evolution.}, archive = {J_ADVS}, author = {Daniel S. Braga and Angus Pedersen and Mohd Riyaz and Jesús Barrio and Alexander Bagger and Itamar T. Neckel and Thiago M. Mariano and Manuel E. G. Winkler and Ifan E. L. Stephens and Maria-Magdalena Titirici and Raphael Nagao}, doi = {10.1002/advs.202510282}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10282}, shortjournal = {Adv. Sci.}, title = {In situ structural evolution and activity descriptor of atomically dispersed catalysts during nitrate electroreduction}, volume = {12}, year = {2025}, }
• (2025). Fast Li₂O₂ electrochemistry enabled by co-Nx/Co (111) with optimized intermediate adsorption. ADVS, 12(39), e10256. (www)

  @article{ , abstract = {The practical development of Li-O 2 batteries (LOBs) urgently needs to explore robust cathode catalysts to boost the sluggish Li 2 O 2 reaction kinetics and parasitic reactions despite their theoretically high specific energy. Profound understanding of the cathode properties and the battery performance is rather critical in developing rational-designed electrocatalysts. In this study, a Co-N x /Co (111) decorated N-doped hierarchical carbon framework (Co-N x /Co@NHCF) is proposed as an efficient cathode in LOBs. Spectroscopic analysis coupled with experimental results suggests that the Co-N x /Co (111) catalytic center can significantly reduce the battery overpotential, and meanwhile, the hierarchical carbon framework ensures rapid mass transportation and provides sufficient space to accommodate Li 2 O 2 deposition. Density functional theory calculations reveal that the incorporated Co (111) facet can effectively regulate the electronic distribution of N-carbon, optimize the adsorption of desirable intermediates, and eventually facilitate oxygen reduction reaction/oxygen evolution reaction kinetics. As expected, the Co-N x /Co@NHCF catalyzed LOBs deliver a high discharge/charge capacity of 6.15/ 6.22 mAh cm −2 with a columbic efficiency of 98.9%, along with a high rate cycling of 700 h at 0.3 mA cm −2 . This work provides valuable instruction for the rational design of efficient catalysts for high-performance LOBs via optimization of the crystal structure and the adsorption of intermediates.}, archive = {J_ADVS}, author = {Lili Liu and Chen Wang and Luxin Zhao and Yayun Xiao and Weiwei Fang and Lanling Zhao and Faxing Wang and Yuping Wu}, doi = {10.1002/advs.202510256}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10256}, shortjournal = {Adv. Sci.}, title = {Fast Li₂O₂ electrochemistry enabled by co-Nx/Co (111) with optimized intermediate adsorption}, volume = {12}, year = {2025}, }
• (2025). Obstacle-immune microwave wireless power transfer system based on amplitude-dependent caustic metasurface. ADVS, 12(39), e10070. (www)

  @article{ , abstract = {Rapid advances in the Internet of Everything (IoE) drive microwave wireless power transfer (MWPT) technology for charging wireless smart devices. However, environmental obstacles and safety concerns associated with high-power transmission present new challenges for the technology. To address these problems, an amplitude-dependent caustic metasurface (ADCMs) design method is proposed for generating self-bending radio frequency circular Airy beams (RFCAB). The self-accelerating circular Airy beam has a natural hollow region, providing an obstacle avoidance and safety zone during microwave transmission focusing. The ADCMs, derived from caustic theory, are capable of generating RFCAB with arbitrary curvatures and offer flexible control over the positioning of the energy focus. An innovative feed architecture, a uniform circular array (UCA) emitting vortex electromagnetic waves, is used to match the amplitude excitation on which the metasurface depends. The designed ADCMs consists of 1/3 wavelength units and contains only two layers of substrate, with high transmittance and full 360 0 phase coverage, ensuring efficient beam generation and manipulation. Simulation and experimental analyses demonstrate the obstacle-avoidance characteristics and safety features under high-power transmission of ADCMs-based MWPT systems. The proposed MWPT system is anticipated to offer an effective obstacle avoidance and safety solution for the wireless charging of devices within the IoE.}, archive = {J_ADVS}, author = {Song Zhang and Hao Xue and Zhe Zheng and Xiangjin Ma and Xin Wang and Jiaqi Han and Haixia Liu and Long Li}, doi = {10.1002/advs.202510070}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10070}, shortjournal = {Adv. Sci.}, title = {Obstacle-immune microwave wireless power transfer system based on amplitude-dependent caustic metasurface}, volume = {12}, year = {2025}, }
• (2025). Non-random distribution of EMS-induced mutations reveals preference for open chromatin and expressed genes in rice. ADVS, 12(39), e10034. (www)

  @article{ , abstract = {Mutagenesis is an effective strategy to generate genetic resources for functional genomics and crop improvement. It is widely accepted that chemical-induced mutations are randomly distributed across the genome. However, the randomness of such mutations remains a matter of scientific debate due to a lack of systematic investigation. Although the basic features of mutations induced by different mutagens are known, it remains unresolved whether these mutations correlate with the chromatin state and gene expression. In this study, genomes of the wild-type and 4,619 mutagenized M3 lines derived from treatment with two concentrations of ethyl methane sulfonate (EMS) are sequenced, identifying over 7 million single-nucleotide mutations (SNP m s) that covered over 97% of genes in the rice genome. Comprehensive analyses integrated with genomic, epigenomic, and expression data revealed that SNP m s are more frequently located in open chromatin regions and actively expressed genes. Within expressed genes, heterozygous SNP m s are enriched both upstream and downstream of transcription start sites (TSSs), whereas homozygous SNP m s are enriched significantly in the upstream regions. These findings demonstrate that EMS-induced mutations are non-randomly distributed across the rice genome, with a preference for functionally important genomic regions.}, archive = {J_ADVS}, author = {Xue-Feng Yao and Yanhong Liu and Zhiyong Li and Guo-Qiang Jiang and Wensheng Wang and Hong Lu and Huihui Li and Zefu Lu and Chun-Ming Liu}, doi = {10.1002/advs.202510034}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e10034}, shortjournal = {Adv. Sci.}, title = {Non-random distribution of EMS-induced mutations reveals preference for open chromatin and expressed genes in rice}, volume = {12}, year = {2025}, }
• (2025). Unraveling the role of MDK-SDC4 interaction in pancreatic cancer-associated new-onset diabetes by single-cell transcriptomic analysis. ADVS, 12(39), e09987. (www)

  @article{ , abstract = {Elevated blood glucose levels may serve as an early indicator of underlying pancreatic cancer. Discriminating between pancreatic cancer-associated new-onset diabetes (PCAND) and new-onset type 2 diabetes mellitus (T2DM) holds promise for enabling an earlier diagnosis of pancreatic cancer. Nevertheless, the absence of effective biomarkers for distinguishing PCAND from the more prevalent new-onset T2DM persists, primarily because of the elusive pathogenesis of PCAND. In this study, the intricate intercellular communication is comprehensively elucidated through single-cell RNA sequencing. The findings identified Midkine (MDK) as a potential mediator of the interaction between tumor and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin production and secretion. Notably, the plasma levels of MDK are higher in patients with PCAND than in those with T2DM. In conclusion, MDK has emerged as a pivotal driver of PCAND pathogenesis and may function as a blood-based biomarker for discriminating between PCAND and T2DM in populations with new-onset diabetes, thereby facilitating the advancement of early detection strategies for pancreatic cancer.}, archive = {J_ADVS}, author = {Zengyu Feng and Jianyao Lou and Chuanshuai Lin and Haocheng Yu and Yuheng Tu and Jiali Gong and Xiawei Li and Yulian Wu}, doi = {10.1002/advs.202409987}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09987}, shortjournal = {Adv. Sci.}, title = {Unraveling the role of MDK-SDC4 interaction in pancreatic cancer-associated new-onset diabetes by single-cell transcriptomic analysis}, volume = {12}, year = {2025}, }
• (2025). Me-4PACz functionalized MXene for halide perovskite solar cells. ADVS, 12(39), e09898. (www)

  @article{ , abstract = {Interfacial passivation employing 2D Ti 3 C 2 MXenes has proved to be an excellent strategy to optimize band alignment and passivate defects, leading to the reduction of non-radiative recombination in Perovskite Solar Cells (PSCs). Here in, the synthesis and functionalization of Ti 3 C 2 MXene are reported with the [4-(3,6-Dimethyl-9 H -carbazol-9-yl)butyl]phosphonic acid molecule (MXene:Me-4PACz), which is proved by XRD and HRTEM-EELS analyses. Its application at the interface between the halide perovskite (HP) and the Spiro-OMeTAD in normal configuration PSCs, results in the enhancement of indoor and outdoor stability. The MXene:Me-4PACz nanomaterial is obtained in the form of nanoneedles, which, applied in complete PSCs, resulted in a power conversion efficiency (PCE) of ≈21.5%, in comparison with the control device with ≈20.1%. The modified device showed a T 88 operational stability obtained at 1000 h for ISOS-L-1 and T 50 at ≈1000 h for ISOS-O-2. While, all the control devices degraded 55% after 1000 h under ISOS-L and almost 100% after 900 h under ISOS-O-2. Characterization analyses indicate that the efficiency and stability enhancement is due to the improved energy band alignment and charge extraction, to the increased perovskite surface hydrophobicity, and the significant reduction of deep and shallow trap states.}, archive = {J_ADVS}, author = {Masoud Karimipour and Nil Monrós Oliveras and Zhenchuan Tian and Francesco Salutari and Maria Chiara Spadaro and Tiankai Zhang and Naji Vahedigharehchopogh and Jordi Arbiol and Feng Gao and Monica Lira-Cantu}, doi = {10.1002/advs.202509898}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09898}, shortjournal = {Adv. Sci.}, title = {Me-4PACz functionalized MXene for halide perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Thermal radiation sensors based on ionic-conducting pectin films. ADVS, 12(39), e09863. (www)

  @article{ , abstract = {Artificial electronic skins that mimic the properties and functionality of human skin are becoming increasingly important for human-robot interactions. One ability of human skin yet to be thoroughly imitated in electronic skins is non-contact temperature sensing. Imitating this property will be useful for creating novel touch-free interfaces for human-centered robotic systems. Ionic-conducting sensing layers made from crosslinked pectin films have recently been found to exhibit extremely high contact temperature sensitivity, several orders of magnitude greater than traditional sensors. However, pectin film sensors suffer from large baseline conductance decays during prolonged measurements, and their non-contact thermal radiation sensing capabilities have not yet been systematically investigated. Here, substantially improved thermal radiation iontronic sensing stability is first demonstrated by implementing an alternating current configuration with the pectin films. The performance of various polymeric coatings is additionally studied for preventing dehydration in pectin films to improve prolonged iontronic sensor performance. It is then shown that the pectin film sensors exhibit non-contact temperature sensing response that closely match analytical models for radiative heat transfer rate. Altogether, the findings demonstrate clear advances toward non-contact temperature-based electronic skins and touch-free interfaces from pectin or other ionic-conducting films.}, archive = {J_ADVS}, author = {Ezekiel Y. Hsieh and Elizabeth T. Hsiao-Wecksler and SungWoo Nam}, doi = {10.1002/advs.202509863}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09863}, shortjournal = {Adv. Sci.}, title = {Thermal radiation sensors based on ionic-conducting pectin films}, volume = {12}, year = {2025}, }
• (2025). Unveiling the corrosion mechanisms of high-entropy RETaO4 through in situ observation. ADVS, 12(39), e09828. (www)

  @article{ , abstract = {The ambiguous understanding of calcium-magnesium aluminosilicate (CMAS) corrosion mechanisms in RETaO 4 has hindered performance optimization through rare-earth compositional engineering. This study systematically investigates the corrosion behavior of 3–10 component RETaO 4 systems. In situ X-ray diffraction/Transmission electron microscope coupled with Electron backscatter diffraction analysis unveils dynamic reaction pathways during the pre-corrosion heating stage, identifying the crystallization and growth patterns of dominant corrosion product pyrochlore-structured (Ca 2-a-b RE a Al b )(Ta 2-c-d Mg c Si d )O 7 . A reaction-diffusion mechanism of CMAS corrosion for RETaO 4 is proposed, highlighting the different behaviors of various rare earth elements in the corrosion process. Among eight types of RETaO 4 , La 1/6 Nd 1/6 Sm 1/6 Eu 1/6 Gd 1/6 Dy 1/6 TaO 4 exhibits the best corrosion resistance, with a relatively thin corrosion layer and the ability to avoid element segregation and localized infiltration. These findings establish composition-property relationships for designing next-generation corrosion-resistant thermal barrier coatings.}, archive = {J_ADVS}, author = {Zeyu Chen and Yiling Huang and Fan Peng and Chucheng Lin and Wei Zheng and Xuemei Song and Yaran Niu and Yi Zeng}, doi = {10.1002/advs.202509828}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09828}, shortjournal = {Adv. Sci.}, title = {Unveiling the corrosion mechanisms of high-entropy RETaO4 through in situ observation}, volume = {12}, year = {2025}, }
• (2025). Localized lead-chelating insulator bottom contact for efficient and stable p-i-n perovskite solar cells. ADVS, 12(39), e09816. (www)

  @article{ , abstract = {The defective bottom interfaces of perovskites and hole-transport layers (HTLs) limit the performance of p-i-n structure perovskite solar cells (PSCs). Here, that adding an ultrathin local contact layer of lead chelation polymer poly (methyl methacrylate) (PMMA) on PTAA HTLs is reported to fill its pinholes and strongly coordinate with the bottom uncoordinated Pb 2+ simultaneously, resulting in a reduced amorphous region in perovskites near HTLs and a passivated perovskite bottom surface. Transient reflection (TR) spectroscopy results show that the ultrathin insulation layer does not affect the charge transport and collection efficiency at the PTAA and perovskite interface. This locally contacted PMMA can trigger a template-induced specific facet orientation growth, regulating the (111) facet as the preferred facet orientation and releasing the residual lattice strain for perovskites. In addition, the deep HOMO energy of PMMA can alleviate the permeation of I 2 into PTAA and suppress the reaction between them. Therefore, a performance of 22.6% and much-enhanced stability (e.g., stability of T 80 for photo-oxygen increased over 5 times, light-thermal over 4 times) of FA 0.90 Cs 0.10 PbI 2.83 Br 0.17 -based PSCs is demonstrated.}, archive = {J_ADVS}, author = {Ying Li and Yan Chen and Kang Ding and Yuanyuan Guo and Yuhan Liu and Shiwei Lu and QingQing Zou and Rongzhou Liang and Sijin Liu and Zhimin Liu and Haipeng Xie and Dongsheng Tang and Le-Man Kuang and Yaxin Zhai and Jifei Wang}, doi = {10.1002/advs.202509816}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09816}, shortjournal = {Adv. Sci.}, title = {Localized lead-chelating insulator bottom contact for efficient and stable p-i-n perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Rationally designed TadA-derived cytosine editors enable context-independent zebrafish genome editing. ADVS, 12(39), e09800. (www)

  @article{ , abstract = {CRISPR base editors are crucial for precise genome manipulation. Existing APOBEC-based cytosine base editors (CBEs), while powerful, exhibit indels and sequence context limitations, and editing CC and GC motifs is challenging and inefficient. To address these challenges, existing tRNA adenine deaminase (TadA)-derived CBEs are evaluated in zebrafish, and a series of zTadCBE variants is developed that demonstrate high editing efficiency, minimized off-target effects, and an expanded targeting range compared to existing tools. The approach integrates beneficial mutations from TadA-based adenine base editors (ABEs) with SpRYCas9n-enhanced protospacer-adjacent motif (PAM) compatibility. The expanded window zTadCBE variants enable the targeting of cytosines at a broader range of nucleotide positions relative to the PAM sequence, further enhancing the versatility of this tool. Using zTadCBEs, four zebrafish disease models affecting the auditory, nervous, metabolic, and muscular systems are generated directly in the F0 generation—models that cannot be efficiently produced using earlier CBE tools. Together, zTadCBE variants provide a robust and flexible toolkit for efficient and precise C-to-T base editing in zebrafish, facilitating rapid in vivo functional assessment of genetic variants.}, archive = {J_ADVS}, author = {Wei Qin and Sheng-Jia Lin and Yu Zhang and Kevin Huang and Cassidy Petree and Kevin Boyd and Pratishtha Varshney and Gaurav K. Varshney}, doi = {10.1002/advs.202509800}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09800}, shortjournal = {Adv. Sci.}, title = {Rationally designed TadA-derived cytosine editors enable context-independent zebrafish genome editing}, volume = {12}, year = {2025}, }
• (2025). Microenvironmental effects on CO2 hydrogenation over PdZn alloy catalysts. ADVS, 12(39), e09726. (www)

  @article{ , abstract = {Understanding catalytic reactions under realistic gas-phase conditions is essential for the computational design of next-generation industrial catalysts with enhanced efficiency and selectivity. In this work, a hybrid quantum/classical framework is employed to systematically investigate the effects of partial pressure, temperature, and surface coverage on CO 2 hydrogenation over PdZn alloy catalysts. The multiscale approach incorporates local gas-phase densities and realistic catalyst structures, enabling accurate prediction of reaction selectivity across operating conditions. The results reveal a temperature-dependent shift in pressure response: at low temperatures, increasing pressure favors the COOH pathway, while at elevated temperatures, the HCOO pathway becomes more competitive as pressure increases. This opposite trend reflects a competition of long-range and short-range interactions between gas molecules and intermediates, which evolves nonlinearly with the system pressure. The surface structure further modulates catalyst-environment interactions by altering local gas accessibility, for example, through suppressing CO 2 adsorption while promoting the catalyst binding of smaller molecules like H 2 . These findings provide a detailed mechanistic understanding of how catalyst structure and reaction environment jointly regulate free-energy pathways in CO 2 hydrogenation. The transferable strategy of integrating microenvironmental effects into first-principles modeling advances the rational design of catalytic systems for efficient CO 2 utilization and broader chemical transformations.}, archive = {J_ADVS}, author = {Jikai Sun and Jianzhong Wu}, doi = {10.1002/advs.202509726}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09726}, shortjournal = {Adv. Sci.}, title = {Microenvironmental effects on CO2 hydrogenation over PdZn alloy catalysts}, volume = {12}, year = {2025}, }
• (2025). Magnetic Fe3O4 nanoparticles modified hydroxyapatite whisker: A novel framework with superior osteogenic efficacy. ADVS, 12(39), e09715. (www)

  @article{ , abstract = {The valid repair of bone defects requires considering precise elements mirroring native tissue and the efficiency of treatment reality. Magnetic biomaterial-mediated mechanotransduction emerges as a critical mechanism for enhancing osteogenic differentiation and bone regeneration. Here, enhancement of osteogenic capacity is achieved in a hydroxyapatite whisker (HAw) by integrating with magnetic Fe 3 O 4 nanoparticles (HAw/Fe 3 O 4 ). The HAw/Fe 3 O 4 exhibited excellent magnetic responsiveness and controllable alignment along magnetic field (MF) vectors enabled precise delivery of programmed mechanical stimuli. In vitro and in vivo experiments showed that Fe 3 O 4 nanoparticles modified HAw has satisfactory biocompatibility and osteoinductivity, while the synergistic efficacy of magnetic biomaterial with external MF stimulation significantly accelerated bone matrix mineralization. The magnetic HAw/Fe 3 O 4 with a MF significantly increased the expression of osteogenic markers and improved bone repair. The mechanosensitive ion channel of Piezo1 enabled efficient transcellular mechanotransduction through the MAPK pathway in response to the magnetic HAw/Fe 3 O 4 with MF stimulation. The current study demonstrates that the HAw/Fe 3 O 4 magnetic framework - developed through Fe 3 O 4 nanoparticle integration to enhance HAw osteoinductivity via coordinated MF application and mechanobiological modulation - served as an optimal therapeutic platform for delivering programmed mechanical cues to activate Piezo1-mediated mechanotransduction cascades, ultimately accelerating bone tissue regeneration.}, archive = {J_ADVS}, author = {Xue Zhang and Qiang Wang and Wanxin Zheng and Zhijian Li and Lanfeng Qu and Yulou Tian and Dan Zhang and Tingting Yan and Qing Zhou}, doi = {10.1002/advs.202509715}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09715}, shortjournal = {Adv. Sci.}, title = {Magnetic Fe3O4 nanoparticles modified hydroxyapatite whisker: A novel framework with superior osteogenic efficacy}, volume = {12}, year = {2025}, }
• (2025). Semiconducting nanomaterials for intrinsically stretchable field-effect transistors. ADVS, 12(39), e09642. (www)

  @article{ , abstract = {Developing intrinsically stretchable field-effect transistors (FETs) is critical for enabling next-generation flexible, wearable, and bio-integrated electronic systems. Unlike conventional stretchable devices that rely primarily on geometric engineering of rigid materials, intrinsically stretchable FETs involve materials that inherently withstand large mechanical deformation while preserving their electronic performance. Although significant progress is achieved in the field of stretchable devices, further innovation in semiconductor materials and compatible process technologies remains essential for advancing the field. This review summarizes recent progress and challenges in intrinsically stretchable semiconducting nanomaterials. Various fabricating processes for stretchable devices are presented, together with recent applications of intrinsically stretchable FETs in sensory technologies, stretchable displays, digital computing, and biomimetic systems. Finally, the remaining challenges and perspectives are summarized for future research directions to realize highly scalable, durable, and high-performance intrinsically stretchable FETs for next-generation electronic platforms.}, archive = {J_ADVS}, author = {Seongmin Heo and Gwon Byeon and Soonhyo Kim and Taoyu Zou and Yong-Young Noh}, doi = {10.1002/advs.202509642}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09642}, shortjournal = {Adv. Sci.}, title = {Semiconducting nanomaterials for intrinsically stretchable field-effect transistors}, volume = {12}, year = {2025}, }
• (2025). A liquid metal-embedded sheath-core fiber with internal helical structure for strain-insensitive electronics. ADVS, 12(39), e09547. (www)

  @article{ , abstract = {Stable conductivity is crucial for flexible wearable devices, ensuring reliable signal transmission, sensing accuracy, optimal display performance, and overall device reliability. However, simultaneously achieving high elasticity, superior conductivity, and robust stability remains a formidable challenge. This study presents a novel core-sheath fiber with an internal helical structure as the core layer and an intrinsic elastic material as the sheath layer, which combines the intrinsic elastic material and extensile spiral structure to realize high stretchability, ultra-conductivity, and strain-insensitivity. The hollow fiber with helical channel is fabricated via coaxial wet-spinning technology by adjusting the flow velocity, with an elongation at break of ≈1440%. Subsequent infusion of liquid metal into the channel endows the fiber with outstanding conductivity, reaching 1.94 × 10 5 S m −1 . Benefiting from the helical structure, the obtained fibers exhibit outstanding strain-insensitivity with a high Q value of 62.5 (resistance variation <1.6%) under 100% strain and show only 30% resistance change even at 600% elongation. The fibers exhibit superior stability against bending, twisting, and compressive deformations. The PU sheath provides excellent waterproof properties, enabling reliable operation in aqueous environments. Moreover, these fibers can be woven into fabrics, exhibiting outstanding performance in joule heaters, near-field communication, and wireless charging applications.}, archive = {J_ADVS}, author = {Mengying Luo and Wanru Wei and Qiye Guo and Weibing Zhong and Kangyu Jia and Kangqi Chang and Ying Lu and Mufang Li and Dong Wang}, doi = {10.1002/advs.202509547}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09547}, shortjournal = {Adv. Sci.}, title = {A liquid metal-embedded sheath-core fiber with internal helical structure for strain-insensitive electronics}, volume = {12}, year = {2025}, }
• (2025). Hinst: Human-like interactive instinct enables robots to robustly accomplish universal tasks. ADVS, 12(39), e09483. (www)

  @article{ , abstract = {Robots have enormous potential to assist humans in daily life. However, current robot development and popularization are impeded by its deficient functionality, lengthy task deployment, and vast experimental training. Poor flexibility, poor practicality, and poor universality in task accomplishment hinder robot applications. Here, a human-like interactive instinct (Hinst) and a Hinst robotic architecture are proposed to enable robots to flexibly and robustly accomplish universal tasks in the real world. The Hinst architecture incorporates multimodal senses, logical decision-making, and initiative task-execution, casting robots with human-like instinctive reaction and intelligence expansion. The robot is empowered with instinctive interaction ability relying on its inherent touch-sense-feedback, knowledge-driven cognition, and adaptive-control, while its high-level intelligence of task-planning and action-skills are nurtured from acquired knowledge-learning or human-teaching. The Hinst greatly enhances the efficiency and the success rate of robotic manipulation, skill learning, and task execution. This anthropomorphic architecture offers a generalizable and universal pathway for general-purpose robots (especially humanoid robots) to robustly accomplish complex housework and industrial skilled work.}, archive = {J_ADVS}, author = {Zijian Liao and Qian Mao and Yichen Qin and Jinfeng Yuan and Rong Zhu}, doi = {10.1002/advs.202509483}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09483}, shortjournal = {Adv. Sci.}, title = {Hinst: Human-like interactive instinct enables robots to robustly accomplish universal tasks}, volume = {12}, year = {2025}, }
• (2025). Facile single-nanocomposite 4D bioprinting of dynamic hydrogel constructs with thickness-controlled gradient. ADVS, 12(39), e09449. (www)

  @article{ , abstract = {The advent of 4D bioprinting has fueled significant progress in tissue engineering, but it faces major challenges such as limited options of smart bioinks and complexity of designing printing paths, limiting its broader application in tissue engineering. In this study, a smart composite hydrogel is first developed by combining gelatin, gelatin methacryloyl, and MXene (MX/GG), exhibiting excellent printability and shape-morphing capabilities. A facile and robust 4D printing strategy is proposed to fabricate MX/GG hydrogels with distinct spatial crosslinking gradients by simply tuning the domain-specific pattern thickness followed by a single UV exposure. Finite element analysis is applied to effectively guide the thickness-controlled shape-morphing process, resulting in precise alignment with the actual curved constructs and reliably predicting the shape transformation of CAD-designed patterns. Inspired by natural shape-morphing systems, a wide range of biomimetic constructs are successfully 4D printed, including unidirectional curved constructs (e.g., five-petal flower) and bidirectional curved constructs (e.g., scorpion). As a proof-of-concept, cell-laden MX/GG bioinks are 4D bioprinted into humidity-driven self-folding strips. Living cells experienced bending-associated strain within 3D constructs and proliferated and functioned effectively. Developed with the facile 4D printing strategy, the MXene-reinforced smart hydrogels hold significant promise for the biofabrication of diverse programmable dynamic tissues and organs.}, archive = {J_ADVS}, author = {Jiahui Lai and Tiandi Xiong and Shangsi Chen and Zhilong Zhou and Jun Liu and Boguang Yang and Rocky S. Tuan and Zhong Alan Li}, doi = {10.1002/advs.202509449}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09449}, shortjournal = {Adv. Sci.}, title = {Facile single-nanocomposite 4D bioprinting of dynamic hydrogel constructs with thickness-controlled gradient}, volume = {12}, year = {2025}, }
• (2025). Near-infrared-responsive digital PCR-assisted renal cancer exosomal miRNAs insights and regulation of macrophage polarization. ADVS, 12(39), e09407. (www)

  @article{ , abstract = {Exosomes derived from tumors are critical agents in intercellular communication and the tumor microenvironment, offering a rich source of signatures for renal cell carcinoma (RCC) diagnosis. Conventional diagnostic techniques often suffer from limited sensitivity and can be invasive. This study presents an innovative approach using near-infrared (NIR) digital PCR (dPCR) with black phosphorus-embedded gelatin microcarriers for profiling exosomal miRNAs and modulating STAT3 signaling and macrophage polarization. Microcarriers produced via microfluidics, characterized by their phase-change and photothermal properties, are subjected to thermal cycling using a custom NIR source. The study identified a 4.2-fold increase in miR-210 levels in RCC cells (ACHN and A498) compared to normal cells (HK-2), with miR-126 and miR-30c levels decreasing by 7–9 times. Additionally, the method achieved a 20-fold enrichment of miRNA-34 in exosomes, leading to reduced STAT3 expression and decreased M2 macrophage polarization after co-incubation. This pioneering dPCR method provides a robust tool for early RCC detection through exosomal miRNA profiling and opens new avenues for therapeutic exosome engineering. The study underscores the potential of dPCR-based exosome genotyping in identifying cancer biomarkers and developing novel treatment strategies.}, archive = {J_ADVS}, author = {Lexiang Zhang and Rokshana Parvin and Siyue Lin and Peiyu Chen and Gangling Wang and Dingmeng Hu and Ke Lin and Yun Cheng and Fangfu Ye and Bing Han and Gen Yang and Dexuan Wang}, doi = {10.1002/advs.202509407}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09407}, shortjournal = {Adv. Sci.}, title = {Near-infrared-responsive digital PCR-assisted renal cancer exosomal miRNAs insights and regulation of macrophage polarization}, volume = {12}, year = {2025}, }
• (2025). Coverable self-cleaning glass via abnormal transport and jump of charged particles. ADVS, 12(39), e09404. (www)

  @article{ , abstract = {Surface particle pollution is present everywhere, from windows in daily life to transparent curtain walls in tall buildings and photovoltaic panels in deserts. Cleaning these particles takes a lot of labor and costs, highlighting a method for dealing with surface particle pollution that is facile, fast, and sustainable. Here, the abnormal reverse lateral transport behavior of charged particles is reported, the mechanism of abnormal transport and jump behaviors is revealed of charged particles, and the phase diagram of the influence of electric field and particle size on these two behaviors is established. Based on this discovery, a transparent and simple self-cleaning glass driven by the electric field is developed, with a thickness of only 0.62 mm, which can achieve a sustainable surface self-cleaning function when facing organic and inorganic particles. Its cleaning time is ultra-fast, and 97.79 g m −2 particles can be cleaned in 10 s. The self-cleaning glass can be easily covered to any object surface to achieve self-cleaning and does not affect the function of the object surface, opening a door for no water consumption, facile, fast, and sustainable self-cleaning of various surfaces.}, archive = {J_ADVS}, author = {Meng Yang and Conglin Li and Wei Tang and Wenchao Gao and Weiguo Weng and Yingchun Wu and Yifan Wang and Chenghang Zheng and Xiang Gao}, doi = {10.1002/advs.202509404}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09404}, shortjournal = {Adv. Sci.}, title = {Coverable self-cleaning glass via abnormal transport and jump of charged particles}, volume = {12}, year = {2025}, }
• (2025). Limpet-inspired multifunctional composite fibers with exceptional mechanical performance from self-assembled aramid nanofibers. ADVS, 12(39), e09321. (www)

  @article{ , abstract = {Aramid nanofibers (ANFs) have emerged as promising building blocks for bioinspired materials due to their exceptional mechanical strength and chemical stability. However, their widespread application has been hindered by the limitations of conventional top-down synthesis from Kevlar, which is costly, inefficient, and offers limited control over molecular structure. Addressing this challenge, a cost-effective, bottom-up strategy is reported to fabricate limpet-inspired composite fibers by combining the self-assembly of ANFs from poly(paraphenylene terephthalamide) polyanions with in situ iron oxide mineralization. This approach enables spontaneous co-alignment of ANFs and β-FeOOH nanowhiskers, emulating the hierarchical architecture of limpet teeth. Guided by hydrogen bonding and π–π stacking, self-assembly regulates nanoscale ordering, crystallinity, and interfacial interactions—critical for enhancing mechanical performance. The resulting fibers exhibit an ultimate strength of 1.8 GPa, modulus of 42.7 GPa, and toughness of 336 MJ m − 3 , surpassing spider silk and many high-performance synthetic fibers. Multiscale toughening mechanisms, including crystallographic slip, melt-recrystallization, and micro-crazing, are enabled by the semicrystalline structure of the ANFs. Beyond mechanical properties, the fibers display paramagnetic behavior and UV resistance. This work introduces a scalable platform for multifunctional composite fibers, integrating molecular-level control with structural biomimicry and advanced functionality.}, archive = {J_ADVS}, author = {Tiantian Ren and Shouhua Feng and Ming Yang}, doi = {10.1002/advs.202509321}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09321}, shortjournal = {Adv. Sci.}, title = {Limpet-inspired multifunctional composite fibers with exceptional mechanical performance from self-assembled aramid nanofibers}, volume = {12}, year = {2025}, }
• (2025). Circular polarimetric imaging with a metamaterial integrated long-wavelength infrared focal plane array. ADVS, 12(39), e09292. (www)

  @article{ , abstract = {Long-wavelength infrared (LWIR) circular polarimetric imaging plays an important role in many areas. The immediacy of polarimetric imaging and the miniaturization of devices drive considerable efforts to division-of-focal-plane-array (DoFPA) circular polarimeters. However, the realization of such detectors is hampered by low polarization discrimination, reduced absorption in the detection material, and fabrication complexity. The situation becomes more serious in the LWIR range since the pixel size is only a few wavelengths of the incident light. Here, a quantum well infrared photodetector based LWIR DoFPA circular polarimeter featuring a 320 × 256 pixel array integrated with a chiral meta-mirror array is established. The spectral range of this detector is from 10 to 11 µm. Taking advantage of the dual polarization selection, a CPER of 23.3 is achieved for the pixels integrated with the same chiral meta-mirror structure, and a CPER of 5.67 for the pixels integrated with left- and right-handed chiral meta-mirror structures in a checkerboard pattern. The peak responsivity is improved by a factor of 9.13 compared to a standard reference device. With the LWIR DoFPA circular polarimeter, Stokes parameter S 3 imaging is achieved with a noise equivalent S 3 difference of 1.16×10 −4 , and demonstrate background suppression and target highlighting.}, archive = {J_ADVS}, author = {Tianyun Zhu and Ling Wang and Wenji Jing and Jie Deng and Jiexian Ye and Yujie Zhang and Zeshi Chu and Jing Zhou and Xiaoshuang Chen and Xiangyang Li and Wei Lu and Xuechu Shen}, doi = {10.1002/advs.202509292}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09292}, shortjournal = {Adv. Sci.}, title = {Circular polarimetric imaging with a metamaterial integrated long-wavelength infrared focal plane array}, volume = {12}, year = {2025}, }
• (2025). Titania nanopores as photoelectrocatalysts for coupling hydrogen production with plastic reformation. ADVS, 12(39), e09287. (www)

  @article{ , abstract = {Photoelectrochemical (PEC) water splitting offers a sustainable pathway for solar-to-chemical energy conversion, yet its efficiency is often limited by sluggish water oxidation and the generation of low-value oxygen. Here, the use of engineered titania nanopore (TNP) films is reported, fabricated via anodization and thermal annealing, as co-catalyst-free photoanodes for coupling hydrogen evolution reaction (HER) with polyethylene terephthalate (PET) reformation into high-value formate. By tuning the crystallographic phase of TiO 2 from amorphous to anatase and rutile, the optimized anatase-phase electrode exhibits excellent PEC performance in a two-electrode configuration, achieving a high steady-state photocurrent density of [2.34 ± 0.67] mA cm −2 , a hydrogen evolution output of 1771 ± 30 µL cm −2 , a formate yield of 1.68 ± 0.05 mmol L −1 , and a Faradaic efficiency of 85 ± 9.0%. Notably, despite the absence of noble metals or complex heterostructures, the PEC performance of the TNP films is comparable to, or even surpasses, that of reported systems employing additional co-catalysts. This study establishes a simple and scalable PEC platform for simultaneous green hydrogen production and plastic waste valorization, offering new opportunities for sustainable energy and environmental technologies.}, archive = {J_ADVS}, author = {Van Truc Ngo and Karan Gulati and Cheryl Suwen Law and Nguyen Que Huong Tran and Jingkai Lin and Damian L. Stachura and Andrew D. Abell and Huayang Zhang and Abel Santos}, doi = {10.1002/advs.202509287}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09287}, shortjournal = {Adv. Sci.}, title = {Titania nanopores as photoelectrocatalysts for coupling hydrogen production with plastic reformation}, volume = {12}, year = {2025}, }
• (2025). Triple-functional CuxAu61-x nanoclusters with NIR-II photoluminescence, photothermal and photodynamic properties and their bio-application. ADVS, 12(39), e09283. (www)

  @article{ , abstract = {Atomically precise gold nanoclusters (NCs) hold great potential in optical and bio-related applications due to their well-defined atomic structures, near-infrared-II (NIR-II) photoluminescence, and excellent biocompatibility. However, many applications require multi-functionality in one entity, which poses significant challenges in the design of materials. Herein, a novel Cu x Au 61-x NC is designed, exhibiting triple functionality, including NIR-II luminescence, strong photothermal effect, and high catalytic activity. Crystallographic analysis reveals a penta-icosahedral, oblate structure, with the Cu atoms being exclusively located in the core region, including one additional Cu atom at the center of the Cu x Au 61-x structure. By comparing with the related, undoped Au 60 NC —which is non-emissive and photocatalytically inactive, deep insights into the enhancement mechanisms are obtained. Furthermore, a multifunctional Cu x Au 61-x @SiO 2 -FA (folic acid) nanoplatform is constructed for potential bio-applications.}, archive = {J_ADVS}, author = {Tingting Xu and Jie Kong and Yu Chen and Wenxue Cui and Yucheng Fang and Wei Zhang and Mohan Wang and Meng Zhou and Yingwei Li and Rongchao Jin and Yongbo Song}, doi = {10.1002/advs.202509283}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09283}, shortjournal = {Adv. Sci.}, title = {Triple-functional CuxAu61-x nanoclusters with NIR-II photoluminescence, photothermal and photodynamic properties and their bio-application}, volume = {12}, year = {2025}, }
• (2025). Reversing hydrogen-related loss in α-ta thin films for quantum device fabrication. ADVS, 12(39), e09244. (www)

  @article{ , abstract = {α-Tantalum (α-Ta) is an emerging material for superconducting qubit fabrication due to the low microwave loss of its stable native oxide. However, hydrogen absorption during fabrication, particularly when removing the native oxide, can degrade performance by increasing microwave loss. This work demonstrates that hydrogen can enter α-Ta thin films when exposed to 10 vol% hydrofluoric acid for 3 min or longer, leading to an increase in power-independent ohmic loss in high-Q resonators at millikelvin temperatures. It is further shown that annealing at 500 °C in ultra-high vacuum (10 −8 Torr) for 1 h fully removes hydrogen and restores the resonators’ intrinsic quality factors to ≈4 million at the single-photon level. These findings identify a previously unreported loss mechanism in α-Ta and offer a pathway to reverse hydrogen-induced degradation in quantum devices based on α-Ta and, by extension also Nb, enabling more robust fabrication processes for superconducting qubits.}, archive = {J_ADVS}, author = {D. P. Lozano and Massimo Mongillo and Bart Raes and Yann Canvel and Shana Massar and A. M. Vadiraj and Tsvetan Ivanov and Rohith Acharya and Jacques Van Damme and Joris Van de Vondel and Danny Wan and Anton Potočnik and K. De Greve}, doi = {10.1002/advs.202509244}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09244}, shortjournal = {Adv. Sci.}, title = {Reversing hydrogen-related loss in α-ta thin films for quantum device fabrication}, volume = {12}, year = {2025}, }
• (2025). Robust antifogging and antifouling coating tailored with zwitterionic nanocellulose for multi-functional applications. ADVS, 12(39), e09204. (www)

  @article{ , abstract = {Biofouling often occurs simultaneously with fogging, presenting significant challenges to visibility, safety, and operational efficiency. The development of biocompatible coatings that offer both antifouling performance and stability under fogging conditions is highly sought after. A method to form multifunctional coatings is presented, utilizing a zwitterionic nanocellulose composite material that demonstrates both antifogging and antifouling properties, suitable for application on various surfaces. Cellulose nanofibers are modified with lysine to impart zwitterionic characteristics, enhancing hydrophilicity and antifouling performance. Polyacrylic acid is incorporated as a binder, ensuring tight integration of the zwitterionic cellulose nanofibers, which further improves coating uniformity, stability, and adhesion. The resulting coating exhibits superior antifogging properties, excellent adhesion resistance, and mechanical strength while remaining nontoxic to biological organisms. This coating effectively addresses practical needs in applications such as medical endoscopy, food preservation, and marine antifouling. The research offers new insights and approaches for the development of eco-friendly and transparent protective coatings.}, archive = {J_ADVS}, author = {Yanyi Duan and Jiangjiexing Wu and Aihua Qiao and Zheng Zhang and Jiaxin Shang and Xiaohui Mao and Xiaohui Yan and Nan Wang and Peng Zhong and Xiaobo Li and Xavier Banquy and Wei Qi and Rongxin Su}, doi = {10.1002/advs.202509204}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09204}, shortjournal = {Adv. Sci.}, title = {Robust antifogging and antifouling coating tailored with zwitterionic nanocellulose for multi-functional applications}, volume = {12}, year = {2025}, }
• (2025). Designing light-sensitive organic semiconductors with azobenzenes for photoelectrochemical transistors as neuromorphic platforms. ADVS, 12(39), e09125. (www)

  @article{ , abstract = {Organic neuromorphic electronics aim to emulate the adaptive behavior of biological synapses using soft, biocompatible materials capable of analog and stimulus-responsive modulation. While azobenzene-based semiconductors provide reversible light-induced switching, their application in mixed ionic-electronic conductors for neuromorphic systems remains largely unexplored. In this study, photoresponsive organic photoelectrochemical transistors (OPECTs) are engineered by functionalizing PEDOT:PSS with azobenzene derivatives bearing nitro or fluorine substituents. These modifications alter the electronic structure and surface properties of the gate, enabling systematic tuning of interfacial capacitance, a critical parameter governing photogating and neuromorphic response. Optical and electrochemical measurements, supported by DFT calculations reveal that substituent-dependent modulation of bulk and interfacial capacitance directly impacts gating efficiency. Devices exhibit reversible, analog conductance changes under optical and electrical co-stimulation, emulating both short- and long-term synaptic plasticity. These results establish a structure–capacitance–function relationship and provide a chemically tunable platform for the development of light-responsive neuromorphic interfaces in adaptive bioelectronics.}, archive = {J_ADVS}, author = {Isabela Berndt Paro and Martina Gini and Francesca D’ Elia and Arianna Massaro and Federica Corrado and Daniela Rana and Ana Varela and Giulia Elli and Matthias Baumann and GiovanniMaria Piccini and Luisa Petti and Daniele Leonori and Ana Belen Muñoz-García and Michele Pavone and Andreas Offenhäusser and Valeria Criscuolo and Francesca Santoro}, doi = {10.1002/advs.202509125}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09125}, shortjournal = {Adv. Sci.}, title = {Designing light-sensitive organic semiconductors with azobenzenes for photoelectrochemical transistors as neuromorphic platforms}, volume = {12}, year = {2025}, }
• (2025). Highly efficient, spatially pure circularly polarized luminescence from bilayer self-assembled colloidal quantum wells and soft helical superstructures. ADVS, 12(39), e09122. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL) is important for multiple photonic technologies. It can be achieved with high asymmetry factors ( g lum ) by combining quantum emitters (QEs) with one-dimensional helical superstructures (1D-HS). However, existing 1D-HS systems face challenges of maintaining polarization purity across viewing angles, primary due to the mismatch between QE emission profiles and the photonic bandgap of 1D-HS across off-normal directions. Herein, efficient and controllable CPL is proposed and developed using the self-assembly of colloidal quantum wells (CQWs) coupled with cholesteric liquid crystals (CLCs). The face-down CQWs assemblies with over 90% in-plane transition dipole moments enables directional emission along the liquid crystal helical axis within the light escape cone. At the same time aligning their narrow emission spectra to the edge of the CLCs reflection band significantly enhances the spectral coupling. This results in highly efficient CPL with an improved g lum of 1.47–1.82 (±0.03) over an expanded viewing range (±40°) and a large increase (53.3%) in extraction efficiency, supported by comprehensive angle-resolved and wavelength-resolved spectroscopy as well as optical simulations. Moreover, this approach facilitates the development of novel anti-peeping and angle-dependent luminescent devices. This work establishes a versatile platform for spatially homogeneous and tunable CPL in next-generation photonic systems.}, archive = {J_ADVS}, author = {Xiao Liang and Thi Thu Ha Do and Lu Ding and Furkan Isik and Anupam Sadhu and Emek G. Durmusoglu and Syed Akhil and Betul Canimkurbey and Lydia H. Wong and Son Tung Ha and Arseniy I. Kuznetsov and Hilmi Volkan Demir}, doi = {10.1002/advs.202509122}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09122}, shortjournal = {Adv. Sci.}, title = {Highly efficient, spatially pure circularly polarized luminescence from bilayer self-assembled colloidal quantum wells and soft helical superstructures}, volume = {12}, year = {2025}, }
• (2025). Bispecific nanosystems enable multieffector immune cell retargeting for hematologic malignancy therapy. ADVS, 12(39), e09103. (www)

  @article{ , abstract = {B-cell lymphomas are hematologic malignancies characterized by poor prognoses. Immunotherapy has revolutionized B-cell lymphoma treatment by harnessing immune effector cells, but current therapeutic strategies face limitations: suboptimal pharmacokinetics of bispecific antibodies and high complexity and cost of chimeric antigen receptor T-cell therapies. To address these challenges, a bispecific nanosystem (biHSNPs) is developed that exploits the multi-functional customizability of silica nanoplatform to conjugate antibodies targeting cytotoxic T cells or natural killer cells, alongside effector antibodies specific to B-cells. Four biHSNPs with different effector and target antibodies are synthesized. This bispecific nanosystem enables simultaneous binding to immune effector cells and B-cell lymphoma antigens, facilitating the formation of artificial immunological synapses. These synapses promote immune effector cell activation, leading to the release of cytotoxic proteins, while concurrently suppressing tumor cell proliferation and enhancing T-cell activation. In vivo, biHSNPs effectively suppress tumor growth and activate T cells in a xenograft mouse model, showcasing their potential in precision therapy. Moreover, biHSNPs successfully overcome tumor immune evasion through dual-target signal blockade. Using a straightforward and scalable strategy, a bispecific nanosystem is constructed that not only addresses the limitations of current bispecific antibody therapies but also represents a promising approach for the treatment of hematological malignancies.}, archive = {J_ADVS}, author = {Yefeng Shen and Xin Li and Jingnan Wu and Yuru Ma and Sven Borchmann and Zhenguo Cheng and Yaohe Wang and Yongliang Zhao and Jian Song and Boyu Luo and Xiuyun Liu and Yue Teng and Zhiyuan Shi}, doi = {10.1002/advs.202509103}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09103}, shortjournal = {Adv. Sci.}, title = {Bispecific nanosystems enable multieffector immune cell retargeting for hematologic malignancy therapy}, volume = {12}, year = {2025}, }
• (2025). Dual mo-doping in BiVO4/FeCoNiOx photoanode enables near-theoretical photocurrent density via synergistic bulk-surface engineering for solar water splitting. ADVS, 12(39), e09037. (www)

  @article{ , abstract = {Bismuth vanadate (BiVO₄) is an auspicious photoanode material for photoelectrochemical (PEC) water splitting, but its performance is fundamentally limited by severe charge recombination and sluggish kinetics of the oxygen evolution reaction (OER). Herein, a dual electronic modulation strategy is developed by incorporating molybdenum (Mo) dopants simultaneously into the FeCoNiO x cocatalyst surface and the bulk phase of BiVO₄. The resulting Mo:FeCoNiO x /Mo:BiVO₄ photoanode delivers a near-theoretical photocurrent density of 7.15 mA cm⁻ 2 at 1.23 V versus reversible hydrogen electrode (RHE) under AM 1.5 G illumination. This exceptional performance arises from the Mo-triggered cross-scale electronic reconstruction: (1) In the bulk, Mo substitution at vanadium (V) sites in BiVO₄ enhances charge transport via n-type doping; (2) At the surface, Mo incorporation into FeCoNiO x triggers electron redistribution, creating localized electron reservoirs at Fe/Co/Ni sites. Combined density functional theory (DFT) calculations and experimental validation reveal that the reconfigured Fe sites serve a dual function as efficient hole traps and highly active OER centers, reducing the reaction energy barrier (ΔG *OH ) by 1.26 eV. Moreover, the optimized interfacial charge transport boosts carrier separation efficiency from 84.9% to 96.5% and accelerates hole migration by 2.7-fold compared to pristine BiVO₄. This work provides insights into multi-scale electronic engineering for solar energy conversion.}, archive = {J_ADVS}, author = {Rongzhe Zhao and Yuchen Zhou and Peng Guo and Rong Mo and Yonghua Tang and Hongxing Li}, doi = {10.1002/advs.202509037}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09037}, shortjournal = {Adv. Sci.}, title = {Dual mo-doping in BiVO4/FeCoNiOx photoanode enables near-theoretical photocurrent density via synergistic bulk-surface engineering for solar water splitting}, volume = {12}, year = {2025}, }
• (2025). Molecular engineering of ionic metal-organic frameworks via ligand conjugation modulation for tailored phosphorescence and multilevel encryption. ADVS, 12(39), e09013. (www)

  @article{ , abstract = {The rational design of metal-organic frameworks (MOFs) with tunable phosphorescence remains challenging due to limited understanding of ligand conjugation effects on excited-state dynamics. Herein, two isomorphic ionic MOFs (IMOF-DMF and IMOF-DEF) are constructed via in situ decarbonylation of DMF/DEF, leveraging guest-ion size to regulate ligand conjugation through modulation of pyridine ring dihedral angles. IMOF-DEF exhibits superior room-temperature phosphorescence (RTP) and temperature-dependent behavior. Mechanistic studies reveal that reduced conjugation enhances intersystem crossing (ISC) by strengthening spin-orbit coupling while minimizing the singlet-triplet energy gap (ΔE st ). Furthermore, a dual-parameter anti-counterfeiting platform and flexible PVA hydrogel films enable advanced information encryption through temperature/time-resolved signals and triple-state lifetime encoding. This work establishes ligand conjugation engineering as a key strategy for tailoring MOF photophysics, linking molecular design to optoelectronic applications and security technologies.}, archive = {J_ADVS}, author = {Qi Wu and Xinyu Gao and Wenyan Zhang and Yaoyu Wang}, doi = {10.1002/advs.202509013}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e09013}, shortjournal = {Adv. Sci.}, title = {Molecular engineering of ionic metal-organic frameworks via ligand conjugation modulation for tailored phosphorescence and multilevel encryption}, volume = {12}, year = {2025}, }
• (2025). Artificial intelligence-assisted urine cytology for noninvasive detection of muscle-invasive urothelial carcinoma: A multi-center diagnostic study with prospective validation. ADVS, 12(39), e08977. (www)

  @article{ , abstract = {Accurate preoperative diagnosis of muscle invasion (MI) is critical for urothelial carcinoma (UC) management. The aim is to evaluate whether artificial intelligence (AI) model based on urine cytology can accurately detect MIUC and compare its performance with radiologist assessments. UC patients underwent liquid-based urine cytology from four centers are included for model development/validation. Performance of the precision urine cytology AI solution for MI (PUCAS-M) is validated across multicenter cohorts and compared to radiologists’ assessments (including CT/MR, MR accounted for 40.7%). Clinical utility is assessed for initial diagnosis, recurrence detection, and neoadjuvant therapy. PUCAS-M achieves an area under the receiver operation curve (AUROC) of 0.857 (95% CI: 0.820-0.895) in the whole validation cohort, which is significantly higher ( P -value = 0.005) than radiologists (0.773, 95% CI: 0.727–0.818). The integration of radiologists' diagnosis and PUCAS-M (mPUCAS-M) significantly increases the sensitivity of radiologists from 63.9% to 83.3% in bladder cancer and from 76.9% to 90.3% in upper-tract UC. Lastly, in the neoadjuvant therapy subgroups, mPUCAS-M maintains an improved AUROC (ranging from 0.857-0.865), whereas radiologist assessments' performance decline. PUCAS-M provides accurate, non-invasive MI detection method, particularly valuable for equivocal imaging. Integration with clinical data enhances diagnostic precision, offering a scalable solution for UC management.}, archive = {J_ADVS}, author = {Runnan Shen and Fan Jiang and Xiaowei Huang and Guibin Hong and Yun Luo and Huan Wan and Ye Xie and Mengyi Zhu and Yun Wang and Bohao Liu and Ping Qin and Yahui Wang and Haoxuan Wang and Hongkun Yang and Zhen Lin and Rui Chen and Nengtai Ouyang and Jian Huang and Tianxin Lin and Shaoxu Wu}, doi = {10.1002/advs.202508977}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08977}, shortjournal = {Adv. Sci.}, title = {Artificial intelligence-assisted urine cytology for noninvasive detection of muscle-invasive urothelial carcinoma: A multi-center diagnostic study with prospective validation}, volume = {12}, year = {2025}, }
• (2025). Donnan-engineered inner helmholtz plane enabling ultra-stable aqueous bismuth electrode. ADVS, 12(39), e08965. (www)

  @article{ , abstract = {The electrochemical instability of the solid-liquid interface remains a critical bottleneck in rechargeable aqueous metal batteries (RAMBs), where traditional strategies fail to resolve the inherent conflict between electrochemical and parasitic reactions at the inner Helmholtz plane (IHP). Herein, inspiring from the ion-sieving principles of the Donnan effect, classical electrostatics is integrated with interfacial engineering by creating a phosphate anion (PO 4 3− )-adsorbed IHP on a bismuth (Bi) electrode. The immobilized PO 4 3− establishes a sustained Donnan potential, driving three key functions: i) ion and reaction sieving through charge-selective ion partitioning, enriching Na⁺ while excluding OH⁻ to enable selective (de)alloying over corrosion reaction; ii) electron confinement through Donnan potential to suppress parasitic electron leakage; and iii) dynamic stabilization of the IHP through strong anion chemisorption, bridging the classical Donnan model with electrochemistry. As a result, the Bi electrode demonstrates a superior cycling stability (200 mAh g −1 retention after 3000 cycles at 2 A g −1 ) and ultrahigh-rate performance (134 mAh g −1 at 16 A g −1 ). By extending the Donnan effect in electrochemistry, the research creates a universal interfacial paradigm based on charge-selective ion partitioning and electron confinement. This breakthrough provides a transformative strategy to decouple desired electrochemical reactions from parasitic side reactions, paving the way for advanced RAMBs.}, archive = {J_ADVS}, author = {Tingting Qin and Wenli Zhang and Dong Wang and Yingguang Zhang and Taowen Dong and Zibo Zhang and Sarah K.W. Leong and Weichen Chen and Samy Mahmoud and Hanqing Liu and Yifei Wang and Xiaolong Zhao and Wei Dong and Meng Ni and Dennis Y.C. Leung and Zhenbin Guo and Wending Pan}, doi = {10.1002/advs.202508965}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08965}, shortjournal = {Adv. Sci.}, title = {Donnan-engineered inner helmholtz plane enabling ultra-stable aqueous bismuth electrode}, volume = {12}, year = {2025}, }
• (2025). Leukemic cells hijack stromal bioelectricity to reprogram the bone marrow niche via CaV1.2-dependent mechanisms. ADVS, 12(39), e08940. (www)

  @article{ , abstract = {Mesenchymal stromal cells (MSCs) are key components of the tumor microenvironment (TME), influencing leukemia progression through poorly understood mechanisms. Here, the bioelectrical properties of MSCs derived from pediatric acute myeloid leukemia (AML) patients (AML-MSCs) are investigated, identifying a significant depolarization of their resting voltage membrane potential (V mem , −14.7 mV) compared to healthy MSCs (h-MSCs, −28.5 mV), accompanied by downregulation of Calcium channel, voltage-dependent, L type, alpha 1C subunit1.2 (CaV1.2) L-type calcium channel expression. AML-MSCs display increased spontaneous calcium oscillations, suggesting altered ion homeostasis. Notably, h-MSCs exposed to AML blasts undergo a similar V mem depolarization (−11.8 mV) and CaV1.2 downregulation, indicating that leukemic cells actively reprogram MSCs. Functionally, V mem depolarization in h-MSCs promotes a pro-leukemic phenotype, whereas hyperpolarization of AML-MSCs restores a normal behavior. CaV1.2 over-expression by lentiviral vectors in AML-MSCs shifts the V mem toward hyperpolarization and partially reverses their leukemia-supportive properties, in part through CaV1.2 transfer via tunneling nanotubes. These findings reveal that AML blasts impose a bioelectrical signature on MSCs, modulating ion channel activity to sustain a leukemic niche. Targeting this electrical reprogramming through CaV1.2 restoration represents a potential strategy to re-establish homeostasis in the bone marrow microenvironment.}, archive = {J_ADVS}, author = {Ambra Da Ros and Maddalena Benetton and Giulia Borella and Giorgia Longo and Giulia Borile and Alice Cani and Diego Lopez-Pigozzi and Mario Bortolozzi and Silvia Bresolin and Claudia Tregnago and Franco Locatelli and Martina Pigazzi}, doi = {10.1002/advs.202508940}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08940}, shortjournal = {Adv. Sci.}, title = {Leukemic cells hijack stromal bioelectricity to reprogram the bone marrow niche via CaV1.2-dependent mechanisms}, volume = {12}, year = {2025}, }
• (2025). Polyphenol-based functional materials: Structural insights, composite strategies, and biomedical applications. ADVS, 12(39), e08924. (www)

  @article{ , abstract = {Polyphenols hold significant promise in pharmaceutical, biotechnology, and food-related applications owing to their potent free radical scavenging, antimicrobial, antitumor, and other properties. The unique chemical architecture, featuring multiple phenolic hydroxyl groups and aromatic ring systems-confers a high capacity for both non-covalent (e.g., hydrogen bonding, π–π stacking, metal ion coordination) and covalent interactions (e.g., Michael addition, Schiff base formation). These versatile interaction modes underpin the rational design and engineering of advanced composite materials with tailored functionalities. Recent advances in nanotechnology and materials science have catalyzed the integration of polyphenols with broad biomaterials, including metals, polysaccharides, and proteins, to enhance their biocompatibility, mechanical properties, and therapeutic efficacy. This review systematically explores the sources, structures, and physiological activities of polyphenols, elucidating their interaction mechanisms with different materials. Emphasis focuses on the design of polyphenol-based nanomaterials, bioactive scaffolds, and smart drug delivery platforms capable of modulating local microenvironments and orchestrating cellular responses for precision therapeutic interventions. The translational potential of these functional materials in regenerative and precision medicine is also critically examined, alongside key challenges such as stability, responsiveness, and the fine-tuning of release kinetics.}, archive = {J_ADVS}, author = {Songwen Xue and Wen Tan and Shuifang Mao and Haibo Pan and Xingqian Ye and Natthawuddhi Donlao and Jinhu Tian}, doi = {10.1002/advs.202508924}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08924}, shortjournal = {Adv. Sci.}, title = {Polyphenol-based functional materials: Structural insights, composite strategies, and biomedical applications}, volume = {12}, year = {2025}, }
• (2025). Prediction of lung cancer metastasis risk based on single-cell metabolic profiling of circulating tumor cells. ADVS, 12(39), e08878. (www)

  @article{ , abstract = {Lung cancer metastasis is a leading cause of cancer-related mortality, necessitating innovative approaches for early prediction and personalized clinical management. A novel strategy is present to predict lung cancer metastasis risk by combining single-cell metabolic profiling of circulating tumor cells (CTCs) with a self-developed CTC sorting and capture platform, enabling high-efficiency, high-viability CTC isolation from blood. Using nanoelectrospray ionization-atmospheric pressure chemical ionization mass spectrometry, single-cell metabolomic profiling on 301 CTCs derived from patients and animal models are performed. 390 unique metabolites are identified and discovered distinct metabolic signatures associated with different metastatic potentials (brain and bone). Based on these metabolic profiles, a classification model that categorizes CTCs into subgroups with distinct metastatic risks are constructed. The model outperformed traditional clinical indicators and total CTC counts, achieving AUCs of 0.74 (brain metastasis) and 0.92 (bone metastasis). Prospective validation confirmed its metabolite-based classification accuracy for one-year metastasis risk prediction. This study highlights the potential of single-cell metabolomics to uncover novel therapeutic targets and prognostic markers, advancing liquid biopsy from quantitative counting to qualitative analysis. The approach represents a significant advancement in precision medicine for lung cancer management, offering a personalized strategy for predicting metastasis risk and guiding clinical treatment.}, archive = {J_ADVS}, author = {Yang Xu and Xuesen Hu and Yuan Yuan and Wenwen Liu and Jian Wang and Chunhui Yang and Xianzhe Shi and Wangshu Qin and Liliang Wen and Manqing Lin and Yinuo Jin and Wei Wang and Chunxiu Hu and Guowang Xu and Qi Wang}, doi = {10.1002/advs.202508878}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08878}, shortjournal = {Adv. Sci.}, title = {Prediction of lung cancer metastasis risk based on single-cell metabolic profiling of circulating tumor cells}, volume = {12}, year = {2025}, }
• (2025). Medium-entropy Alloy/Oxide nano composite for high-performing high-temperature CO2 electrolysis with remarkable carbon deposition resistance. ADVS, 12(39), e08800. (www)

  @article{ , abstract = {Conventional solid oxide electrolysis cells (SOECs) with nickel/yttria-stabilized zirconia (Ni/YSZ) electrodes suffer from low CO 2 reduction activity and severe carbon deposition below 800 °C, limiting scalability. This study introduces a novel medium-entropy alloy/Mn-based oxide composite catalyst deposited via simple infiltration onto the fuel electrode, creating hierarchical heterogeneous metal/oxide nano-interfaces. The catalyst-decorated cell achieves a remarkable 46% increase in CO 2 electrolysis current density, reaching 2.15 A cm −2 at 1.5 V and 750 °C. Simultaneously, the catalyst demonstrates exceptional carbon deposition resistance, evidenced by a 75% increase in the current density threshold for carbon formation. The cell maintains stable, carbon-free operation for 200 h at an extreme current density of 1.0 A cm −2 . Comprehensive analyses combining in situ characterization and density functional theory (DFT) calculations revealed the enhanced performance originates from synergistic effects between the unique composition of the medium-entropy alloy and Mn-based oxides, and their distinctive nanostructured interfaces. This work presents a promising approach for developing advanced electrode materials for CO 2 electrolysis in SOECs, significantly contributing to the scalability and practical application of this critical technology.}, archive = {J_ADVS}, author = {Jun Tong and Haewon Seo and Yunseo Choi and Ji-eun Won and Jinhong Park and Keun Hwa Chae and Jongsup Hong and Hye Jung Chang and Baowen Zhou and Rongchang Cao and Na Ni and Kyung Joong Yoon and Lei Zhu and Zhen Huang}, doi = {10.1002/advs.202508800}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08800}, shortjournal = {Adv. Sci.}, title = {Medium-entropy Alloy/Oxide nano composite for high-performing high-temperature CO2 electrolysis with remarkable carbon deposition resistance}, volume = {12}, year = {2025}, }
• (2025). Meta-dispersive 3D chromatic confocal measurement. ADVS, 12(39), e08774. (www)

  @article{ , abstract = {3D reconstruction can perceive the detailed structures of real-world objects. Integrating metasurfaces with stereo vision or structured-light projection enables compact and efficient 3D reconstruction systems, beneficial for next-generation sensing, augmented reality, and biomedical applications. Nevertheless, the limitations inherent in these visual measurement methods pose a significant challenge to achieving higher resolution. Here, a dispersive metalens (DML) combined with the chromatic confocal method is proposed to achieve high-precision 3D measurement. With appropriate engineered dispersion, the linearity of the dispersion is well maintained, alongside diffraction-limited focusing performance. As a proof-of-concept, experiments on both longitudinal and transversal measurements are conducted. Following the calibration of the DML, axial accuracy of ±4 µm and a subwavelength axial resolution of 0.325 µm is achieved. The successful reconstruction of a fabricated 3D USAF-1951 resolution test chart further corroborates the 3D measurement capability, demonstrating a lateral resolution exceeding 4.38 µm. It is envisioned that the proposed method will pave the way for future applications in areas such as microstructure characterization, industrial inspection, and on-chip 3D optical metrology.}, archive = {J_ADVS}, author = {Jiajun Wu and Jin Yao and An Ren and Zhizheng Ju and Rong Lin and Zhihui Wang and Wule Zhu and Bingfeng Ju and Din Ping Tsai}, doi = {10.1002/advs.202508774}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08774}, shortjournal = {Adv. Sci.}, title = {Meta-dispersive 3D chromatic confocal measurement}, volume = {12}, year = {2025}, }
• (2025). Impact of oxygen vacancies in LiCoO2 on the electrochemical performance of garnet-based all-solid-state li-metal batteries. ADVS, 12(39), e08750. (www)

  @article{ , abstract = {Garnet-structured Li 7 La 3 Zr 2 O 7 (LLZO) is considered as one of the most promising solid electrolytes for high safety all-solid-state Li batteries (SSLBs) applications. However, this type of SSLB utilizing LiCoO 2 /LLZO as composite cathode faces high capacity degradation because of delamination between LiCoO 2 (LCO) and LLZO and possible oxygen vacancy-driven microcrack formation within LCO. Herein, a pure oxygen atmosphere is used for sintering the composite cathode to limit oxygen vacancy formation in LCO. Different sintering temperatures are also used to reduce the effect of sintering atmospheres, which suggests the non-reversible oxidation peak at ∼3.8 V is not related to Li 2 CO 3 formation. Although the Coulombic efficiencies of the first electrochemical cycle of SSLBs sintered in pure oxygen atmosphere are improved, their electrochemical performances are lower than that of air-sintered SSLB due to higher cell resistances from the reduction of oxygen vacancies in LCO and possible higher volume change during electrochemical cycling. Also, the lower electrochemical cycling performance and observing tens of micrometers long inter-granular cracks in the highly dense composite cathode suggests that microstructural optimization is more important than a high relative density. These observations provide guidelines for further improving the electrochemical cycling performance of garnet-structure-based SSLBs toward practical applications.}, archive = {J_ADVS}, author = {Zhizhen Qin and Jehad Ahmed and Sebastian Speer and Dmitri L. Danilov and Anna Windmüller and Shicheng Yu and Chih-Long Tsai and Hermann Tempel and Josef Granwehr and Wen-Wei Wu and Jeng-Kuei Chang and Rüdiger-A. Eichel and Peter H. L. Notten}, doi = {10.1002/advs.202508750}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08750}, shortjournal = {Adv. Sci.}, title = {Impact of oxygen vacancies in LiCoO2 on the electrochemical performance of garnet-based all-solid-state li-metal batteries}, volume = {12}, year = {2025}, }
• (2025). Biocompatible mesoporous materials for bone therapy. ADVS, 12(39), e08740. (www)

  @article{ , abstract = {As global population aging intensifies, bone-related diseases have become a significant public health challenge, necessitating the development of efficient and precise bone repair strategies. Biocompatible mesoporous materials (BMMs), characterized by their high specific surface area, tunable pore size, multidimensional functionalization potential, and excellent biocompatibility, have demonstrated revolutionary application prospects in treating bone-related diseases. This review systematically summarizes the latest research progress and application mechanisms of BMMs (e.g., mesoporous silica, mesoporous bioactive glass) in bone-related diseases. It also thoroughly discusses the synthesis methods and functionalization strategies of BMMs, including designs for biocompatibility and biodegradability, targeting capabilities, bio-responsiveness, and regulation of cellular behavior. The article emphasizes and analyzes the preclinical research applications of BMMs in bone-targeted drug delivery, bone tissue engineering, bone implant coatings, and integrated diagnosis and therapy. Finally, it provides a retrospective analysis and future perspectives on the application of BMMs in bone-related diseases, aiming to promote a transition from fragmented breakthroughs to systematic development in BMMs research. This effort seeks to provide a scientific framework for optimizing material design and advancing clinical applications.}, archive = {J_ADVS}, author = {Biao Yu and Yan Wu and Yang Hong and Peng Wang and Xiaowen Liu and Yonghui Deng and Jiacan Su}, doi = {10.1002/advs.202508740}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08740}, shortjournal = {Adv. Sci.}, title = {Biocompatible mesoporous materials for bone therapy}, volume = {12}, year = {2025}, }
• (2025). Artificial intelligence is stereotypically linked more with socially dominant groups in natural language. ADVS, 12(39), e08623. (www)

  @article{ , abstract = {Despite the increasingly important role that artificial intelligence (AI) plays in society, its social representation remains underexplored. This study reveals that AI is asymmetrically stereotyped, being more closely associated with socially dominant groups. This conclusion is based on these investigations of AI's associations along the warmth–competence dimensions of the stereotype content model, its connections with socially advantaged (e.g., men, young, rich, white) versus disadvantaged (e.g., women, old, poor, non-white) demographic groups, and its perceived impact on high- versus low-prestige occupations. Across four studies using language-based analyses with static word embeddings, BERT-based models, and GPT-4o, as well as human-participant experiment validation, it is found that i) AI is strongly associated with high competence but exhibits variability in the warmth dimension (Study 1); ii) AI is more closely linked to advantaged demographic groups (Study 2); iii) advantaged demographic groups are semantically closer to AI than their disadvantaged counterparts along the warmth–competence dimensions (Study 3); and iv) high-prestige occupations (rather than low-prestige ones) are associated more strongly with AI's benefits than with its threats. Together, these findings indicate that public perceptions of AI are systematically biased toward socially dominant groups, potentially reinforcing existing social inequalities and raising concerns about an emerging “AI divide.”}, archive = {J_ADVS}, author = {Zixi Wang and Haodong Xia and Han Wu Shuang Bao and Yiming Jing and Ruolei Gu}, doi = {10.1002/advs.202508623}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08623}, shortjournal = {Adv. Sci.}, title = {Artificial intelligence is stereotypically linked more with socially dominant groups in natural language}, volume = {12}, year = {2025}, }
• (2025). Slide-crosslinked polyrotaxane topological networks: Quasi-solid electrolyte for high-voltage lithium metal batteries. ADVS, 12(39), e08598. (www)

  @article{ , abstract = {Although polymer-based electrolytes offer advantages like low cost, favorable interfacial compatibility, and processability for solid-state lithium metal batteries with high safety and high energy density, conventional linear polymer-based electrolytes suffer from inadequate oxidation resistance and mechanical strength at operating voltages above 4.5 V, causing rapid capacity degradation and reduced battery lifespan. Inspired by the mechanical slide-ring structure of polyrotaxanes (PR), a series of high-voltage-resistant sliding crosslinked quasi-solid electrolytes (PMBA-PPR x ) is designed and synthesized via in situ thermal polymerization of varying amounts of vinyl functional polyrotaxanes (PPRs) with N,N'-methylenebisacrylamide (MBA). The optimal PMBA-PPR 5 electrolyte realizes the synergistic enhancement of both mechanical properties and high-voltage-resistant electrochemical properties as well as the good interfacial compatibility. The dynamic slide ring structure of PPRs effectively dissipates the energy generated by lithium dendrite growth, thereby maintaining the mechanical robustness of the electrolyte during battery cycling and achieving lithium deposition/stripping behavior for more than 2000 h at 0.5 mA cm −2 . The strong polar amide groups of MBA not only improve the lithium-ion transference number (0.69), but also enhance the high-voltage stability of the electrolyte (∼ 5.5 V), ultimately resulting in excellent cycling stability and capacity retention of Li|PMBA-PPR 5 |LFP and Li|PMBA-PPR 5 |NCM811 cells. This slide-crosslinked polyrotaxane topological dynamic structure provides a new strategy for the design of high-voltage lithium metal electrolytes.}, archive = {J_ADVS}, author = {Huirong Zhu and Xiaoyue Zeng and Xuewei Liu and Jiaxing Zhu and Jinghao Hua and Jinle Lan and Yunhua Yu and Xiaoping Yang}, doi = {10.1002/advs.202508598}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08598}, shortjournal = {Adv. Sci.}, title = {Slide-crosslinked polyrotaxane topological networks: Quasi-solid electrolyte for high-voltage lithium metal batteries}, volume = {12}, year = {2025}, }
• (2025). Glucose deprivation-induced disulfidptosis via the SLC7A11-INF2 axis: Pan-cancer prognostic exploration and therapeutic validation. ADVS, 12(39), e08556. (www)

  @article{ , abstract = {Disulfidptosis, a novel form of regulated cell death, involves cytoskeletal collapse due to excessive disulfide bond formation, linking metabolism and reactive oxygen species to potential cancer therapy targets. Recent multi-omics studies highlight the prognostic value of disulfidptosis-related gene (DRG) signatures in pan-cancers; however, the molecular mechanisms underlying their biological functions and therapeutic relevance remain poorly defined. Herein, a DRG score model is constructed using LASSO Cox regression across 33 cancer types, and a nomogram incorporating the DRG score is developed for prognostic prediction. The tumor microenvironment, mutation profiles, and immunotherapy responses are analyzed. The DRG score serves as an independent prognostic factor across cancers, correlating with poor outcomes and malignant features. Glucose deprivation induces disulfidptosis in SLC7A11 high cells (high SLC7A11 expression), especially in cancers with a high DRG score, such as ovarian cancer. Silencing INF2 prevents disulfidptosis and decreases susceptibility to irofulven, which can be reversed by GLUT inhibitors. SLC7A11 knockdown reduces disulfidptosis, restores ATP/NADPH levels, and protects the cytoskeleton under glucose deprivation, whereas INF2 knockdown impairs cell migration. Moreover, the DRG scores predict prognosis and therapeutic responses. The SLC7A11-INF2 axis regulates disulfidptosis, migration, and drug sensitivity, highlighting its potential as a marker of metabolic vulnerability in ovarian cancer.}, archive = {J_ADVS}, author = {Zhenyu Song and Qiuming Yao and Lina Huang and Dan Cui and Jun Xie and Leilei Wu and Jianfeng Huang and Bo Zhai and Dan Liu and Xiao Xu}, doi = {10.1002/advs.202408556}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08556}, shortjournal = {Adv. Sci.}, title = {Glucose deprivation-induced disulfidptosis via the SLC7A11-INF2 axis: Pan-cancer prognostic exploration and therapeutic validation}, volume = {12}, year = {2025}, }
• (2025). Analyses of GWAS and sub-threshold loci lead to the discovery of dendrite development and morphology dysfunction underlying schizophrenia genetic risk. ADVS, 12(39), e08519. (www)

  @article{ , abstract = {Schizophrenia (SCZ) is highly polygenic, and its biological underpinnings remain unclear. In this study, a cost-effective strategy of including sub-threshold GWAS (subGWAS) loci (i.e., 5 × 10 −8 < P ≤ 10 −6 ) in analysis is explored to increase the inference power of novel pathways. A total of 180 subGWAS loci are identified from SCZ GWAS studies and are shown to contain substantial true genetic association signals. By jointly modeling GWAS (sigGWAS) and subGWAS loci, 304 high-confidence risk genes (HRGs) are identified, as well as a novel category of biological processes detected only in subGWAS loci, i.e., dendrite development and morphogenesis (DDM). Two candidate DDM genes ( CUL7 and DCC ), whose risk alleles in GWAS are associated with increased expression, are examined, and it is observed that upregulation of these genes leads to reduced neurite length. It is further revealed that the DDM genes lead to disrupted regulatory programs of the transcription factors CUX1/2 and NEUROD1 . Collectively, the study identifies DDM as a novel biological process in SCZ susceptibility, with particular implications for DCC - and CUL7 -mediated alterations in neurite development and reveals regulatory programs involved in perturbation of the two candidate genes.}, archive = {J_ADVS}, author = {Rui Chen and Benjamin Siciliano and Quan Wang and Chongchong Xu and Qiang Wei and Hai Yang and James S Sutcliffe and Yi Jiang and Ying Ji and Chunyu Liu and Feixiong Cheng and Edwin H Cook and Nancy J Cox and Xue Zhong and Zhexing Wen and Bingshan Li}, doi = {10.1002/advs.202508519}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08519}, shortjournal = {Adv. Sci.}, title = {Analyses of GWAS and sub-threshold loci lead to the discovery of dendrite development and morphology dysfunction underlying schizophrenia genetic risk}, volume = {12}, year = {2025}, }
• (2025). A universal approach using water-soluble templates for meso- and macro-porous organic polymers. ADVS, 12(39), e08489. (www)

  @article{ , abstract = {Porous functional organic polymers have attracted significant interest due to their diverse applications in adsorption/separation, electrocatalysis, photocatalysis, photosensing, and electronics. In these applications, performance depends on interactions between guest molecules and polymer frameworks. Consequently, the introduction of mesopores (2–50 nm) and macropores (50–300 nm) can significantly enhance functionality by simultaneously increasing the exposed active surface area and facilitating molecular diffusion within the polymer matrix. However, a wide range of porous polymers achievable through previous approaches, including surfactant and polystyrene templating, has been severely limited to a few less functional polymers due to the typically aqueous environment used during templating reaction and the need for template removal after polymerization. In this work, a universal approach is demonstrated that utilizes water-soluble templates to synthesize functional meso- and macro-porous organic polymers via solid-state polymerization of aldehydes and amines (Schiff reaction), using perovskite metal fluorides (K M F 3 ) as sacrificial templates. By precisely tuning the particle sizes of metal fluoride templates, accurate control over pore sizes across the mesoscopic and macroscopic scales is achieved. A variety of aldehyde-amine combinations yield semiconductive meso- and macro-porous organic polymers. This versatile synthetic strategy is broadly applicable to a wide range of polymer systems, enabling simultaneous enhancement of surface area and molecular diffusion, thereby optimizing functional performance.}, archive = {J_ADVS}, author = {Yusuke Asakura and Steven Adiwijaya and Shunya Yoshino and Hideki Kato and Yusuke Yamauchi}, doi = {10.1002/advs.202508489}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08489}, shortjournal = {Adv. Sci.}, title = {A universal approach using water-soluble templates for meso- and macro-porous organic polymers}, volume = {12}, year = {2025}, }
• (2025). Impact of controlled magneto-structural coupling in MnCoGe-based compounds on the design of multifunctional materials for technological advances. ADVS, 12(39), e08438. (www)

  @article{ , abstract = {Tailoring the magneto-structural coupling in magnetic martensitic materials is pivotal for optimizing multifunctional properties such as magnetocaloric effect (MCE) and negative thermal expansion (NTE). This study demonstrates how Ni substitution in Mn 1- x Ni x CoGe ( x = 0.03 to 0.07) modulates the magneto-structural transitions as investigated by in-situ X-ray diffraction, magnetization measurements, and geometric compatibility analysis. Ni doping is shown to stabilize the hexagonal phase, lower the martensitic transformation temperature, and introduce intermediate ferromagnetic hexagonal (FM-Hex) states, thereby altering the transition pathways from a single paramagnetic hexagonal (PM-Hex) ↔ ferromagnetic orthorhombic (FM-Orth), to a two-step PM-Hex ↔ FM-Hex ↔ FM-Orth sequence. This modification in the magneto-structural coupling alleviates lattice incompatibility, broadens phase transition temperature window, and enhances magnetization changes during the phase transition. The magnetocaloric refrigeration capacity increases from 213(14) J kg −1 for x = 0.04 to 308(18) J kg −1 for x = 0.07 under a 5 T driving field, while the NTE coefficient is tuned from -375(1) × 10 −3 K −1 for x = 0.05 to -143(1) × 10 −3 K −1 for x = 0.07. These findings provide mechanistic insights into the interplay between magnetization states and lattice compatibility, thereby advancing the design of energy-efficient solid-state cooling and precision actuators through controllable magneto-structural coupling.}, archive = {J_ADVS}, author = {Kang Liu and Xiaowen Hao and Wayne D. Hutchison and Stewart J. Campbell and Xiaoming Huang and Cuiping Zhang and Guoliang Li and Xuefei Miao and Fengjiao Qian and Jianli Wang and Qingyong Ren}, doi = {10.1002/advs.202508438}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08438}, shortjournal = {Adv. Sci.}, title = {Impact of controlled magneto-structural coupling in MnCoGe-based compounds on the design of multifunctional materials for technological advances}, volume = {12}, year = {2025}, }
• (2025). Enhanced superconductivity in X4H15 compounds via hole-doping at ambient pressure. ADVS, 12(39), e08419. (www)

  @article{ , abstract = {This study presents a computational investigation of X 4 H 15 compounds (where X represents a metal) as potential superconductors at ambient conditions or under pressure. Through systematic density functional theory calculations and electron–phonon coupling analysis, it is demonstrated that electronic structure engineering via hole doping dramatically enhances the superconducting properties of these materials. While electron-doped compounds with X 4 + cations (Ti, Zr, Hf, Th) exhibit modest transition temperatures of 1–9 K, hole-doped systems with X 3 + cations (Y, Tb, Dy, Ho, Er, Tm, Lu) show remarkably higher values of ≈50 K at ambient pressure. Superconductivity in hole-doped compounds originates from stronger coupling between electrons and both cation and hydrogen phonon modes. Although pristine X 3 + 4 H 15 compounds are thermodynamically unstable, a viable synthesis route via controlled hole doping of the charge-compensated YZr 3 H 15 compound is proposed. The calculations predict that even minimal concentrations of excess Y can induce high-temperature superconductivity while preserving structural integrity. This work reveals how strategic electronic structure modulation can optimize superconducting properties in hydride systems, establishing a promising pathway toward practical high-temperature conventional superconductors at ambient pressure.}, archive = {J_ADVS}, author = {Kun Gao and Wenwen Cui and Tiago F. T. Cerqueira and Hai-Chen Wang and Silvana Botti and Miguel A. L. Marques}, doi = {10.1002/advs.202508419}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08419}, shortjournal = {Adv. Sci.}, title = {Enhanced superconductivity in X4H15 compounds via hole-doping at ambient pressure}, volume = {12}, year = {2025}, }
• (2025). Re-entrant super-repellent metallic structures for robust anti-icing. ADVS, 12(39), e08272. (www)

  @article{ , abstract = {Superhydrophobic surfaces exhibit significant potential for anti-icing applications. However, sustaining the superhydrophobic Cassie-Baxter state under conditions of low temperature, high humidity, and dynamic impacts remains a critical challenge. Re-entrant structures, as a milestone advance in the study of super-repellent surfaces, not only render material surfaces the Cassie-Baxter state when contacting with liquids beyond water, but also raise a capability in keeping the super-repellent surfaces effective under broader environmental conditions. However, most studies on re-entrant super-repellent structures focus on their room-temperature performances. The water-repellent capabilities of re-entrant structures under low-temperature conditions and their anti-icing performances, in particular, are yet to be elucidated. Herein, re-entrant structures are designed and fabricated directly on metal surfaces, which exhibit remarkable anti-icing performances, including ultra-long icing delay (> 600 min), ultra-low ice adhesion strength (1.6 kPa), and significant durability (ice adhesion strength staying < 25 kPa after 100 deicing cycles). Through systematic characterizations and careful thermodynamic analysis, the underlying mechanisms for the remarkable anti-icing performances are revealed. This study not only validates the effectiveness of re-entrant structures under low-temperature conditions but also engineers the design and fabrication of re-entrant structures for excellent anti-icing performances, establishing a new paradigm for designing robust anti-icing surfaces.}, archive = {J_ADVS}, author = {Daizhou Li and Lizhong Wang and Rui Peng and Ziyan Song and Zhao Liu and Zhixuan Chang and Hongjun Zhang and Peixun Fan and Minlin Zhong}, doi = {10.1002/advs.202508272}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08272}, shortjournal = {Adv. Sci.}, title = {Re-entrant super-repellent metallic structures for robust anti-icing}, volume = {12}, year = {2025}, }
• (2025). In situ polymerization controlled growth of perovskite via benzoic acid crosslinking agent for highly efficient and mechanically robust flexible perovskite solar cell. ADVS, 12(39), e08253. (www)

  @article{ , abstract = {The controlled growth of perovskite on flexible substrates is essential for achieving highly efficient and stable flexible perovskite solar cells (FPSCs). Herein, a novel strategy of 4-hydroxybenzoic acid (4-HBA) is developed to regulate the crystallization dynamics of perovskite. In situ cross-linking network of 4-HBA provided an excellent formwork for high-quality perovskite growth by controlling excessive nucleation and prolonging crystallization. Grain boundary defects, residual stress, and Young's modulus of the perovskite film are greatly decreased. The dynamic hydrogen bonds between free hydroxyl groups and carboxyl groups/halogen enhanced the self-healing ability of perovskite film. The electrostatic interaction between the benzene ring of 4-HBA and uncoordinated Pb²⁺, coupled with π-π stacking of 4-HBA, enhanced the conductivity of perovskite film. As a result, the optimal power conversion efficiency (PCE) of rigid perovskite solar cells (PSCs) and FPSCs reached 24.76% and 22.73%, respectively. The FPSCs retained 91% of initial efficiency after 10 000 bending cycles at 5 mm radius. The FPSCs after 4000 bends at 2 mm radius, regained 89% original PCE with 60℃ heating. The unencapsulated FPSCs retained 83% original PCE after 1000 h of Air Mass 1.5 Global illumination. This work offered an efficient strategy for high-efficiency and robust FPSCs.}, archive = {J_ADVS}, author = {Yankun Yang and Na Yang and Chenxi Zhang and Shiqi Li and Yang Hao and Qinjun Sun and Zhihui Chen and Shengzhong (Frank) Liu and Fei Guo and Jianfeng Lu and Yuying Hao}, doi = {10.1002/advs.202508253}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08253}, shortjournal = {Adv. Sci.}, title = {In situ polymerization controlled growth of perovskite via benzoic acid crosslinking agent for highly efficient and mechanically robust flexible perovskite solar cell}, volume = {12}, year = {2025}, }
• (2025). Multi-dimensional synergistic engineering for boosting nanozyme catalysis. ADVS, 12(39), e08150. (www)

  @article{ , abstract = {Pursuing nanozymes with predominant catalytic activities holds great potential in meeting the needs of multi-field applications, such as in the environment, yet remains challenging. Herein, the cutting-edge strategies for boosting nanozyme catalysis are systematically analyzed from four synergistic dimensions, and a theoretical framework is developed integrating morphological structure, electronic structure, external stimulation, and machine learning (ML)-aided design. From the morphological perspective, the structure-activity relationship between nanostructures and catalytic performance is elucidated, revealing the regulatory mechanism underlying active site exposure, substrate accessibility, and electron transfer kinetics. Subsequently, the electronic structure governed by catalytic activities through precisely optimizing adsorption energy and reaction pathways, such as d -band center, e g occupancy, defect engineering, spin state, etc., is discussed in depth. Then, the mechanism underlying the dynamic regulation of catalytic activity via external stimulations, such as ultrasound, light, electric field, etc., is systematically summarized. Notably, the revolutionary role of ML-driven high-throughput screening in analyzing complex structure-activity relationships and accelerating the discovery of high-performance nanozymes is emphasized. Ultimately, this paper highlights the key role of interdisciplinary integration, encompassing material science, catalytic engineering, and artificial intelligence, etc., in overcoming current bottlenecks, unlocking the potential of nanozymes to address global challenges, and providing a new perspective for advancing the development of nanozymology.}, archive = {J_ADVS}, author = {Yuechun Li and Zhaowen Cui and Chenxin Ji and Cancan Jia and Wentao Zhang and Jianlong Wang and Yizhong Shen}, doi = {10.1002/advs.202508150}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08150}, shortjournal = {Adv. Sci.}, title = {Multi-dimensional synergistic engineering for boosting nanozyme catalysis}, volume = {12}, year = {2025}, }
• (2025). Iridium oxide shell structure on rutile titanium oxide for efficient supported catalyst for the oxygen evolution reaction. ADVS, 12(39), e08036. (www)

  @article{ , abstract = {Proton exchange membrane water electrolysis is a promising technology for the production of hydrogen via water electrolysis. Lower amounts of iridium oxide are needed at the anode to reduce the cost and precious metal dependence of this technology for large-scale development. The use of iridium oxide catalysts supported on non-precious supports can help reduce the required iridium loading. This work presents a novel core–shell structure in which a thin layer of IrO₂ is grown on rutile TiO₂ spheres. The structural compatibility between rutile IrO₂ and rutile TiO₂ enables the formation of a continuous IrO₂ shell, unlike on anatase-rich TiO₂ supports, where only a decorated structure is observed. The core–shell architecture and homogenous IrO₂ distribution on the rutile support is confirmed by imaging, diffraction, and spectroscopy. Electrochemical evaluation demonstrates superior mass activity and pseudo-capacitance for the core-shell material (on rutile) than for the decorated structure (on anatase). The core-shell supported material as electrochemical performance similar to a commercial unsupported IrO₂ catalyst. These results highlight the potential of the rutile IrO 2 -rutile TiO 2 interaction for improving catalyst utilization. Such core-shell materials are promising candidates for an integration in low-loading systems where unsupported materials suffer in-plane conductivity losses.}, archive = {J_ADVS}, author = {Elena Cazzulani and Camille Roiron and Lindsay Zhang and Giovanni Ferro and Alasdair Fairhurst and Pierangela Cristiani and Gian Luca Chiarello and Plamen Atanassov}, doi = {10.1002/advs.202508036}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e08036}, shortjournal = {Adv. Sci.}, title = {Iridium oxide shell structure on rutile titanium oxide for efficient supported catalyst for the oxygen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). Guest-induced reversible phase conversion via spin frustration relief in spin-intercalated layered antiferromagnets. ADVS, 12(39), e07957. (www)

  @article{ , abstract = {A spin-intercalated layered metal-organic framework (MOF) magnetic system, [MCp* 2 ][{Ru 2 (2,3,5-F 3 ArCO 2 ) 4 } 2 (TCNQ)]·solv (M = Co, Fe; [MCp* 2 ] + = decamethylmetallocenium; 2,3,5-F 3 ArCO 2 − = 2,3,5-trifluorobenzoate; solv = crystallization solvent) is reported, which enables reversible magnetic phase switching by controlling spin frustration. In this system, paramagnetic spins ([FeCp* 2 ] + with S = 1/2) are intercalated into a strongly correlated layered antiferromagnet, leading to competition between the interlayer antiferromagnetic coupling ( J LL < 0) and another coupling between the host and intercalated spins ( J LS ). The balance between these interactions governs the emergence and nature of spin frustration. When | J LS | ≤ | J LL |, the spin frustration is “evident,” resulting in a magnetic order accompanied by spin reorientation, whereas when | J LS | >> | J LL |, the frustration becomes “hidden,” and the system exhibits apparent ferromagnetic or ferrimagnetic behavior despite underlying interlayer antiferromagnetic interactions. Importantly, for the first time, a reversible transition between these two magnetic regimes is demonstrated, by controlling the solvation/desolvation of materials, which modulates the spin frustration degree without altering the intrinsic spin states. This controllable switching highlights the unique potential of spin-intercalated molecular layered magnets as tunable platforms for studying correlated spin systems. These findings provide fundamental insights into frustration-driven magnetic phase transitions and open new avenues for developing switchable functional materials.}, archive = {J_ADVS}, author = {Qingxin Liu and Honoka Nemoto and Wataru Kosaka and Hitoshi Miyasaka}, doi = {10.1002/advs.202507957}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e07957}, shortjournal = {Adv. Sci.}, title = {Guest-induced reversible phase conversion via spin frustration relief in spin-intercalated layered antiferromagnets}, volume = {12}, year = {2025}, }
• (2025). A “3+2” cooperation pattern of amphipathic AIE phototheranostic system for multimodal image-guided synergistic type I/II photodynamic-photothermal therapy. ADVS, 12(39), e07956. (www)

  @article{ , abstract = {Phototheranostic agents (PTA) control the process of phototheranostics for cancer. However, the existing PTA still cannot meet the needs of practical biomedical applications. Hence the development of new PTA will be imperative. In this contribution, a “3+2” cooperation pattern of amphipathicity PTA (named TDTMSB) with aggregation-induced emission (AIE) features is designed and synthesized to perform near-infrared I/II fluorescence imaging, photoacoustic imaging, photothermal imaging, and Type I/II photodynamic therapy (PDT)-photothermal therapy (PTT) synergistic phototherapy for malignant tumors. Briefly, the target products (TMSB, TTMSB and TDTMSB) are successfully prepared by the reaction of 2-methyl-1-(3-sulfonatepropyl)-benzothiazolium (MSB) and triphenylamine derivatives. They have high rotor twisted structure, doner-acceptor (D-A) conformation and unique AIE performances. Compared to TMSB and TTMSB, the TDTMSB exhibits a long near infrared emission that extends into the NIR II region, large Stokes shift (300 nm) and small energy gap. Simultaneously, it shows high ROSs generation capacity ( 1 O 2 , OH, and O 2 − ), photothermal conversion efficiency (up to 40.5%), and specific recognition of lysosomes in tumor cells. Furthermore, TDTMSB not only exhibits excellent multimodal imaging capabilities, but also carry out Type I/II PDT-PTT synergistic enhancement effect for malignant tumor. Therefore, TDTMSB is expected to be a promising PTA for multimodal image-guided phototherapy of tumors.}, archive = {J_ADVS}, author = {Haijun Ma and Yibo An and Yuanyuan Han and Feifan Zhao and Yunfei Zuo and Guokang He and Zhixiang Lu and Ryan T. K. Kwok and Jianwei Sun and Jacky W. Y. Lam and Yen Wei and Ben Zhong Tang}, doi = {10.1002/advs.202507956}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e07956}, shortjournal = {Adv. Sci.}, title = {A “3+2” cooperation pattern of amphipathic AIE phototheranostic system for multimodal image-guided synergistic type I/II photodynamic-photothermal therapy}, volume = {12}, year = {2025}, }
• (2025). Long non-coding RNA IGFRIL couples with PTBP1 to destabilize IGFBP3 mRNA to promote the IGF1R-AKT-mTOR axis and hepatocellular carcinoma. ADVS, 12(39), e07676. (www)

  @article{ , abstract = {The incomplete understanding of the IGFR pathway activation mechanism limits its clinical application in hepatocellular carcinoma (HCC). Here, a transcriptome-wide screening is performed and a novel HCC-associated lncRNA, named IGFR-inducing lncRNA ( IGFRIL ) is identified. IGFRIL is frequently upregulated in HCC tissues and predicts poor clinical outcomes. It is revealed that IGFRIL plays an oncogenic role in the development of HCC. Mechanistically, IGFRIL serves as a scaffold to recruit PTBP1, destabilizing IGFBP3 mRNA and thereby overactivating the IGF1R-AKT-mTOR signaling in HCC cells. Furthermore, it is observed that the inhibitors against IGF1R or mTOR exhibit suppressive effects on patient-derived tumor xenograft tumors with high IGFRIL expression, through simultaneous blocking of the IGF1R-AKT-mTOR signaling pathway. In summary, this study identifies IGFRIL as a novel non-coding activator of the IGF1R pathway, providing a promising new therapeutic target for HCC patients.}, archive = {J_ADVS}, author = {Jing Zhang and Chengming Gao and Haibei Li and Yuying Chen and Liting Yang and Qian Jin and Lan Feng and Xia Wang and Xinyi Liu and Hongxia Chen and Rong Ye and Yuanchao Xue and Huiyun Wang and Musheng Zeng and Ming Yang and Huaiqiang Ju and Chengzhi Gao and Guangming Zhou and Qi Zhang and Qian Zhang and Geng Qin and Yuanfeng Li and Yahui Wang and Aiqing Yang and Anfeng Si and Qingfeng Song and Fuchu He and Pengbo Cao and Gangqiao Zhou}, doi = {10.1002/advs.202507676}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e07676}, shortjournal = {Adv. Sci.}, title = {Long non-coding RNA IGFRIL couples with PTBP1 to destabilize IGFBP3 mRNA to promote the IGF1R-AKT-mTOR axis and hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Directed self-assembly of magnetic bioceramic deep inside dentinal tubules may alleviate dental hypersensitivity. ADVS, 12(39), e07664. (www)

  @article{ , abstract = {Delivery of regenerative medicine in complex, microscale topographies can revolutionize multiple areas of healthcare, including but not limited to orthopaedics and dentistry. The technical challenges include navigation and regeneration of nanoscale biosimilars with spatial control, necessitating a different technological approach, as demonstrated here. The specific problem addressed here is dental hypersensitivity, which occurs when dentinal tubules are exposed to the external environment through enamel loss or cementum erosion of the tooth, thus stimulating nerves located in the peripheral odontoblast zone of the pulp. Existing treatments, such as sensitive toothpaste and adhesive resins, are limited to the surface and can only provide short-term relief. Here, we deploy a confluence of distinct experimental strategies to develop a magnetic bioglass-based nanomaterial called “CalBots,” consisting of a Calcium-based colloidal gel that self-assembles into short chains under optimized conditions of external magnetic fields and interparticle interactions and penetrates more than 300 µm deep inside the complex topography of the dentine tissue. Subsequently, it triggers the formation of a biocompatible seal, thus protecting the exposed tubules and their nerve fibers from external stimuli, for both human and murine teeth. The controlled animal trial shows a full recovery from dental hypersensitivity within the treatment group.}, archive = {J_ADVS}, author = {Shanmukh Peddi and Prajwal Hegde and Prannay Reddy and Anaxee Barman and Arnab Barik and Debayan Dasgupta and Ambarish Ghosh}, doi = {10.1002/advs.202507664}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e07664}, shortjournal = {Adv. Sci.}, title = {Directed self-assembly of magnetic bioceramic deep inside dentinal tubules may alleviate dental hypersensitivity}, volume = {12}, year = {2025}, }
• (2025). Enhancing z spin generation in trivial spin hall materials for scalable, energy-efficient, field-free, complete spin-orbit torque switching applications. ADVS, 12(39), e07581. (www)

  @article{ , abstract = {Despite the remarkable efforts in the past two decades, it has remained a major challenge to achieve switching of perpendicularly magnetized spin-orbit torque devices in a scalable, energy-efficient, field-free, integration-friendly, and complete manner. Here, a giant enhancement of z spin generation in low-resistivity spin Hall metal/FeCoB devices is reported by alloying the spin Hall metal Pt with Ti and by electric asymmetry engineering. The damping-like spin torques of z spins and y spins are enhanced by 6 and 3 times relative to those of conventional Pt/FeCoB and enable complete, record-low-power, deterministic switching of FeCoB devices with strong perpendicular magnetic anisotropy and high coercivity. The Pt 75 Ti 25 /FeCoB heterostructure also exhibits relatively low resistivity, wafer-scale uniform sputterdeposition on silicon oxide, good compatibility with magnetic tunnel junctions, and excellent thermal stability of exceeding 400 °C. These results unambiguously establish the Pt 75 Ti 25 /FeCoB as the most compelling candidate for solving the bottleneck of scalable, energy-efficient, field-free, integration-friendly, and complete spin-orbit torque switching technologies. This work also provides a universal strategy for developing high-performance generators of z -spin current and will stimulate the exploration of exotic spin currents by alloying “trivial” spin Hall materials.}, archive = {J_ADVS}, author = {Qianbiao Liu and Lijun Zhu}, doi = {10.1002/advs.202507581}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e07581}, shortjournal = {Adv. Sci.}, title = {Enhancing z spin generation in trivial spin hall materials for scalable, energy-efficient, field-free, complete spin-orbit torque switching applications}, volume = {12}, year = {2025}, }
• (2025). Metasurface-driven adaptive structured light: Achieving integrated real-time 3D reconstruction and forward ranging in multi-scene. ADVS, 12(39), e07339. (www)

  @article{ , abstract = {In structured light-based three-dimensional (3D) reconstruction technology, normal and grazing emission beams hold significant application value due to their stable axial propagation characteristics and anti-distortion advantages. However, current systems face two major technical bottlenecks. First, traditional grazing emission beams depend on the precise assembly of complex optical components, which compromises reliability and impedes miniaturization. Second, the physical constraints of light field transmission make it challenging to generate both modes simultaneously within a single system. This study exploits the light waves modulation capabilities of metasurface to achieve the simultaneous generation of normal and grazing emission dual-mode beams. Specifically, an adaptive closed-line structured light with a central bright spot is generated within 2π space. By integrating a self-developed multimodal point cloud enhancement algorithm, a 3D reconstruction and forward ranging system adaptable to diverse scenarios has been successfully developed. This system achieves real-time 3D reconstruction and forward ranging at 30 fps without additional ranging modules. This technology not only transforms the hardware architecture of existing structured light systems and surpasses the limit of light emission angles but also overcomes the application constraints of traditional methods in diverse scenarios. It provides innovative technological support and solutions for the digital construction of tunnel engineering.}, archive = {J_ADVS}, author = {Zhengren Zhang and Mengran Yang and Anjun Qu and Zile Li and Shaohua Yu and Guoxing Zheng}, doi = {10.1002/advs.202507339}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e07339}, shortjournal = {Adv. Sci.}, title = {Metasurface-driven adaptive structured light: Achieving integrated real-time 3D reconstruction and forward ranging in multi-scene}, volume = {12}, year = {2025}, }
• (2025). NamiRNA-enhancer network: The changing era challenge and chance of miRNA. ADVS, 12(39), e06830. (www)

  @article{ , abstract = {MicroRNAs (miRNAs) systematically orchestrate multiple biological processes via gene regulation in various organisms. Conventionally, miRNAs bind to untranslated regions of mRNAs to modulate gene silencing in the cytoplasm. Recent studies have revealed that a subset of miRNAs located in the nucleus can efficiently activate gene transcription by targeting enhancers, named as Nuclear Activating miRNAs (NamiRNAs). The fundamental principle of this regulatory pattern is that NamiRNAs as “wedges” open double strands of genomic DNA and provide the prerequisite for RNA polymerase II-mediated transcription. Specifically, NamiRNAs bind to their target enhancers and form the hybrids of miRNAs and single-stranded DNA, which are recognized by Argonaute 2 (AGO2) to maintain the single-stranded state. Meanwhile, AGO2 protects these miRNA-DNA hybrids from RNase H-mediated degradation to maintain their stability. Additionally, NamiRNAs induce H3K27ac enrichment at target enhancers and put them into an active state conducive to gene activation. Notably, similar to NamiRNAs, Human Identical Sequences as exogenous small RNAs as critical pathogenic factors for RNA viruses, facilitate infectious disease progression. Collectively, this review systematically elucidates the theory of NamiRNA-Enhancer-mediated Gene Activation in combination with corresponding evidence, summarizes the functions and challenges of NamiRNAs, and discusses their potential in fundamental research and clinical applications.}, archive = {J_ADVS}, author = {Lu Chen and Ying Liang and Hongyan Wei and Mengxing Liu and Jin Wu and Wei Li and Wenxuan Li and Yuxiao Jin and Yinshan Li and Wei Zhao and Min Xiao and Kaicheng Zhou and Shuai Yang and Wenqiang Yu}, doi = {10.1002/advs.202506830}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e06830}, shortjournal = {Adv. Sci.}, title = {NamiRNA-enhancer network: The changing era challenge and chance of miRNA}, volume = {12}, year = {2025}, }
• (2025). Molecular engineering empowers phenanthraquinone organic cathodes with exceptional cycling stability for lithium- and aqueous zinc-ion batteries. ADVS, 12(39), e06749. (www)

  @article{ , abstract = {Organic electrode materials have garnered great attention in recent years, owing to their resource sustainability, structural diversity, and superior compatibility with various ionic species. Among them, quinone-based compounds have attracted particular interest. Notably, compared with para-quinone analogs (e.g., anthraquinone), ortho-quinone-based electrode materials (e.g., phenanthraquinone) demonstrate higher redox potential, which contributes to achieving higher energy density in battery applications. However, their practical applications have been limited by severe solubility in electrolytes, resulting in poor cycle performance. To improve it, two novel phenanthraquinone-derived molecules, 1,4-bis(9,10-phenanthraquinonyl)benzene (BPQB) and 1,3,5-tri(9,10-phenanthraquinonyl)benzene (TPQB), are rationally designed, synthesized, and applied as cathode materials for both lithium-ion batteries (LIBs) and aqueous zinc-ion batteries (AZIBs). Comprehensive electrochemical evaluations reveal remarkable cycling stability and rate performance of TPQB. The TPQB cathodes for LIBs achieve a high-capacity retention of 76.8% after 1,000 cycles at 5 C, while exhibiting extraordinary ultra-long cycle life in AZIBs with 93.2% capacity retention over 6,000 cycles at 5 C. Their charge storage mechanisms are elucidated through various characterization methods. The work presents a novel molecular engineering strategy that effectively inhibits the dissolution of phenanthraquinone-derived electrode materials and thus realizes excellent electrochemical performance across diverse battery systems.}, archive = {J_ADVS}, author = {Susu Li and Haoyu Zhang and Jixing Yang and Yunhua Xu and Yuesheng Li}, doi = {10.1002/advs.202506749}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e06749}, shortjournal = {Adv. Sci.}, title = {Molecular engineering empowers phenanthraquinone organic cathodes with exceptional cycling stability for lithium- and aqueous zinc-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Florigen and florigen-like genes regulate temperature-responsive flowering in tomato. ADVS, 12(39), e06711. (www)

  @article{ , abstract = {Seasonal temperature fluctuations serve as crucial environmental cues that regulate plant reproductive timing, yet the mechanisms underlying thermoresponsive flowering regulation in tomato remain poorly understood. The study uncovers a temperature-sensing mechanism in the tomato shoot apical meristem coordinated through antagonistic interactions between a florigen-like protein FLOWERING LOCUS T-Like 2 (FTL2) and florigen protein SINGLE-FLOWER TRUSS (SFT). Under short day conditions, FTL2 expression is specifically upregulated at the shoot apex by high temperature and functions as a flowering repressor. FTL2 physically interacts with the floral inducer SFT, directly suppressing its transcriptional activity to delay floral transition. This FTL2-SFT regulatory circuit enables tomato precise integration of photoperiodic and thermal signals at the shoot apex, providing a molecular framework for seasonal flowering adaptation. The findings elucidate a fundamental mechanism of temperature perception in tomato flowering control and provide broader insights into how florigen-based networks contribute to adaptive flowering control across plant species.}, archive = {J_ADVS}, author = {Jia Song and Shiqi Zhao and Siyu Fang and Xiaotian Wang and Shuai Sun and Baohua Li and Ren Li and Lu Liu and Xia Cui}, doi = {10.1002/advs.202506711}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e06711}, shortjournal = {Adv. Sci.}, title = {Florigen and florigen-like genes regulate temperature-responsive flowering in tomato}, volume = {12}, year = {2025}, }
• (2025). MRI-derived lymph nodes morphological and topological structure (LNs-MTS) model for evaluating immune status and prognosis in rectal cancer. ADVS, 12(39), e06523. (www)

  @article{ , abstract = {Tumor-draining lymph nodes (LNs) immune status critically influences cancer progression and treatment response, yet reliable non-invasive assessment remains clinically unavailable. To address this critical gap, an MRI-derived LNs morphological and topological structure (LNs-MTS) model is developed to evaluate the immune status of LNs in rectal cancer (RC). Integrating multicenter imaging, transcriptomic, and immunohistochemical data from 1,156 stage I-II RC patients, enhanced immune activation in non-metastatic LNs sized ≥0.5 cm and located ≥5 cm from the primary tumor is discovered. Then two quantitative MRI-derived imaging features across 7,030 radiologically annotated LNs: total LNs volume (tLNV) and total LNs drainage distance (tLND) is developed, forming the basis of the LNs-MTS model risk subtypes: high-risk (HRS), moderate-risk (MRS), and low-risk (LRS). Patients in the LRS (characterized by large tLNV and distant tLND) show robust immune cell infiltration in the tumor microenvironment and excellent 5-year survival, whereas HRS (characterized by small tLNV and near tLND) show stromal dominance and poorer prognosis. Clinically, LNs-MTS offers a more precise and personalized risk assessment than current guideline-based risk stratification, potentially sparing stage II-LRS patients from unnecessary adjuvant treatment while identifying stage I-HRS individuals for more aggressive treatment, providing valuable insights for personalized treatment strategies in RC management.}, archive = {J_ADVS}, author = {Yunxiao Liu and Liwen Zhang and Yanfen Cui and Weiyuan Zhang and Hanqing Hu and Shuai Jiao and Jian Ma and Jiale Li and Jun Xiang and Jinna Li and Haiyi Liu and Xiaotang Yang and Jie Tian and Xishan Wang and Guiyu Wang and Xu Guan}, doi = {10.1002/advs.202506523}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e06523}, shortjournal = {Adv. Sci.}, title = {MRI-derived lymph nodes morphological and topological structure (LNs-MTS) model for evaluating immune status and prognosis in rectal cancer}, volume = {12}, year = {2025}, }
• (2025). Rapid-turnaround co-administration of mRNA-based MHC-I and MHC-II-restricted neoantigens enhances immune responses of antigen-specific CD8+ t cells and anti-cancer efficacy in colorectal cancer. ADVS, 12(39), e06426. (www)

  @article{ , abstract = {Personalized cancer vaccines (PCVs) represent a promising frontier in cancer immunotherapy; however, challenges in neoantigen prediction and treatment optimization persist. This study aims to introduce an innovative mRNA-based PCV platform that addresses these limitations. Co-administration of our major histocompatibility complex (MHC)-I and MHC-II-restricted neoantigens increases antigen-specific T cell responses and exhibits strong anti-cancer efficacy, significantly inducing antigen-specific CD8 + T cell-immune responses. The mRNA-based vaccine targeting the novel antigens demonstrates anti-tumor efficacy in a murine model of colorectal cancer and reduces post-surgery recurrence in mRNA-vaccinated mice. Notably, early-stage vaccination induces a striking anti-cancer effect, underscoring the critical role of MHC-II neoantigens alongside MHC-I antigen prediction in shaping effective anti-tumor immunity, in the activation of antigen-specific CD8 + T cells. In addition, the combination of immune checkpoint inhibitors and the vaccine synergistically inhibits tumor growth by inducing robust T cell responses and promoting favorable alterations in the tumor microenvironment. Taken together, the results provide a strong rationale for the clinical investigation of rapid-turnaround co-administration of MHC-I/II-restricted neoantigens-based mRNA vaccines in colorectal cancer, as supported by the anti-tumor efficacy of early-stage application and combination immunotherapy approaches.}, archive = {J_ADVS}, author = {Seongje Cho and Woori Kwak and Hyunho Yoon and Jisun Lee and Seonghyun Lee and Hyo-Jung Park and Sohee Jo and Yu-Sun Lee and Yu-Jeong Seo and Youngran Cho and Seo-Hyeon Bae and Subin Yoon and Gahyun Roh and Dahyeon Ha and Ayoung Oh and Eun-Jin Choi and Soo-Yeon Lee and Huijeong Choi and Jungmin Kim and Yeeun Lee and Sowon Lee and Sang-In Park and Dae-Keun Kim and Jun Chang and Ki Tae Kim and Kwoneel Kim and Jae-Hwan Nam}, doi = {10.1002/advs.202506426}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e06426}, shortjournal = {Adv. Sci.}, title = {Rapid-turnaround co-administration of mRNA-based MHC-I and MHC-II-restricted neoantigens enhances immune responses of antigen-specific CD8+ t cells and anti-cancer efficacy in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Discovering uncharted binding pockets on e3 ligases leads to the identification of FBW7 allosteric modulators. ADVS, 12(39), e06068. (www)

  @article{ , abstract = {E3 ligases are key regulators of the ubiquitin-proteasome system (UPS) and have emerged as attractive drug target candidates for precise therapeutic intervention. Additionally, their ligands are extremely valuable as handles for Targeted Protein Degradation (TPD). However, only a limited number of E3 ligases have been targeted with small molecules. An efficient approach to identify ligandable surfaces on 22 structurally diverse E3 ligases has been developed, revealing that they offer significant binding opportunities through allosteric pockets. As a proof of concept, an allosteric pocket identified in FBW7 has been targeted, leading to the discovery of the first potent and reversible small-molecule binders of this E3 ligase. Biophysical and structural studies have confirmed the binding site, while functional cell assays have showed that some of these molecules act as allosteric enhancers of c-MYC and c-JUN degradation in an FBW7-dependent manner. These allosteric modulators of E3 ligases represent a novel mechanism of action in the TPD landscape and could be used as PROTAC handles.}, archive = {J_ADVS}, author = {Míriam Martínez-Cartró and Álvaro Serrano-Morrás and Andrea Bertran-Mostazo and Roger Castaño-Muñiz and Salvatore Scaffidi and Varbina Ivanova and Noémi Csorba and József Simon and Péter Ábrányi-Balogh and Yunfeng Li and György M. Keserü and Bing Hao and Xavier Barril and Carles Galdeano}, doi = {10.1002/advs.202506068}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e06068}, shortjournal = {Adv. Sci.}, title = {Discovering uncharted binding pockets on e3 ligases leads to the identification of FBW7 allosteric modulators}, volume = {12}, year = {2025}, }
• (2025). Dual-ionic weakly solvating electrolyte design enables efficient fast-cycling of high-voltage anion shuttle batteries. ADVS, 12(39), e05982. (www)

  @article{ , abstract = {Electrolytes shape solvation structures that govern ionic transport, stability, and interfacial properties in energy storage systems. Sodium-based dual-ion shuttling systems offer high-voltage and fast-charging potential but face challenges such as solvent co-intercalation, electrolyte decomposition, and low Coulombic efficiency, partly due to limited anion-focused electrolyte design. Herein, a low-concentration dual-ionic weakly solvating electrolyte (DWSE) is introduced, leveraging functionalized nano-graphene oxide additives to modulate the solvation environments of Na + and PF 6 − . While a conventional cationic weakly solvating electrolyte (CWSE) enhances Na + transport, DWSE simultaneously addresses anion and cation transport for a more balanced approach. DWSE prevents solvent co-intercalation, stabilizes interfaces with NaF-rich layers, and enhances ionic transport. It achieves a reversible capacity of 82.0 mAh g −1 at 50 C and retains 96.2% capacity after 1500 cycles at 10 C. This study offers a robust framework for advancing dual-ion shuttling systems with optimized cation and anion dynamics.}, archive = {J_ADVS}, author = {Jieun Kang and Inhui Lee and Gwonho Yu and Jin Jun Heo and Yuri Choi and Sangyeop Lee and Sungho Kim and Dongjoo Kim and Jungki Ryu and Seoin Back and Soojin Park and Jaegeon Ryu}, doi = {10.1002/advs.202505982}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e05982}, shortjournal = {Adv. Sci.}, title = {Dual-ionic weakly solvating electrolyte design enables efficient fast-cycling of high-voltage anion shuttle batteries}, volume = {12}, year = {2025}, }
• (2025). Plasma metabolic profile with machine learning reveals distinct diagnostic and biological signatures for pathologic myopia. ADVS, 12(39), e05861. (www)

  @article{ , abstract = {Pathologic myopia (PM), characterized by serious myopic macular degeneration (MMD), is a detrimental subtype of high myopia (HM) and has become one of the leading causes of blindness worldwide. In this concern, precise and high-throughput molecular diagnosis and further pathologic insights are urgently needed. Here, through the combined strategy of nanoparticle-enhanced laser desorption/ionization mass spectrometry-based rapid metabolic analysis (<30 s) and machine learning, a precise molecular diagnostic approach of PM (HM with MMD grade ≥ 2) is proposed, which achieves areas under the curve of 0.874 and 0.889 for diagnosing PM and early-stage PM, respectively. Further, the biomarkers indicate the PM-associated systemic metabolic reprogramming of amino acid and lipid metabolism, which may mediate dysfunctional oxidative stress, inflammation, hormone/neurotransmitter systems, and energy metabolism. Notably, MMD grade 4, featuring characteristic macula atrophy, exhibits specificity in this metabolic reprogramming. Of these biomarkers, azelaic acid shows a significant protective effect in the ARPE-19 cells under abnormal oxidative stress, which may be involved in PM development as a key antioxidative active metabolite. This work will contribute to PM molecular diagnosis and pathology exploration.}, archive = {J_ADVS}, author = {Ziheng Qi and Jiao Qi and Ye Zhang and Yanhui Wang and Yuchen Feng and Zifan Yang and Yating Wang and Weikang Shu and Dongling Guo and Ching Kang and Keke Zhang and Yi Lu and Jingjing Wan and Xiangjia Zhu}, doi = {10.1002/advs.202505861}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e05861}, shortjournal = {Adv. Sci.}, title = {Plasma metabolic profile with machine learning reveals distinct diagnostic and biological signatures for pathologic myopia}, volume = {12}, year = {2025}, }
• (2025). Nanomaterials trigger functional anti-tumoral responses in primary human immune cells. ADVS, 12(39), e05729. (www)

  @article{ , abstract = {Targeting the immune system with nanoparticles (NPs) to deliver immunomodulatory molecules emerged as a solution to address intra-tumoral immunosuppression and enhance therapeutic response. While the potential of nanoimmunotherapies in reactivating immune cells has been evaluated in several preclinical studies, the impact of drug-free nanomaterials on the immune system remains unknown. Here, the molecular and functional response of human NK cells and pan T cells to a selection of five NPs that are commonly used in biomedical applications are characterized. After a pre-screen to evaluate the toxicity of these nanomaterials on immune cells, ultrasmall silica-based gadolinium (Si-Gd) NPs and poly(lactic- co -glycolic acid) (PLGA) NPs are selected for further investigation. Bulk RNA-sequencing and flow cytometry analysis showcase that PLGA NPs trigger a transcriptional priming toward activation in NK and pan T cells. While PLGA NPs improved NK cells anti-tumoral functions in a cytokines-deprived environment, Si-Gd NPs significantly impaired T cells activation as well as functional responses to a polyclonal antigenic stimulation. Altogether, PLGA NPs are identified as an attractive strategy for reactivating the immune system of cancer patients.}, archive = {J_ADVS}, author = {Vincent Mittelheisser and Olivier Lefebvre and Mainak Banerjee and Shayamita Ghosh and Amandine Dupas and Marie-Charlotte Diringer and Juliette Blumberger and Louis Bochler and Sébastien Harlepp and Annabel Larnicol and Angélique Pichot and Tristan Stemmelen and Anne Molitor and Chloé Moritz and Christine Carapito and Raphaël Carapito and Loïc J. Charbonnière and François Lux and Olivier Tillement and Jacky G. Goetz and Alexandre Detappe}, doi = {10.1002/advs.202505729}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e05729}, shortjournal = {Adv. Sci.}, title = {Nanomaterials trigger functional anti-tumoral responses in primary human immune cells}, volume = {12}, year = {2025}, }
• (2025). Targeting eRNA-producing super-enhancers regulates TNFα expression and mitigates chronic inflammation in mice and patient-derived immune cells. ADVS, 12(39), e05214. (www)

  @article{ , abstract = {Chronic inflammatory diseases are driven by immune cell dysregulation and overproduction of pro-inflammatory molecules, such as tumor necrosis factor alpha (TNFα). Super-enhancers (SEs) and their enhancer RNAs (eRNAs) are critical gene expression regulators and offer therapeutic potential beyond protein-targeting approaches. This work hypothesizes that targeting eRNAs could reduce chronic inflammation by modulating TNFα expression. This work generates TNF-9 knockout (KO) mice by deleting a Tnfα-regulating enhancer region. These mice exhibit significantly reduced Tnfα levels, improved disease outcomes, and diminished immune cell activation in models of rheumatoid arthritis (RA), psoriasis, and lipopolysaccharide (LPS)-induced sepsis. Integrative epigenomic and transcriptomic analysis identify additional LPS-responsive, eRNA-producing enhancers as therapeutic targets. Antisense oligonucleotide (ASO)-mediated knockdown of TNF-9 eRNA in mouse macrophages demonstrate decreased Tnfα expression and alleviated RA symptoms. Furthermore, ASO-mediated inhibition of the eRNA of the human homolog of TNF-9 similarly reduce TNFα levels. These findings support eRNA-targeted interventions as potential treatment for chronic inflammatory diseases.}, archive = {J_ADVS}, author = {Minjeong Cho and Su Min Kim and Jiyeon Lee and Oh Chan Kwon and Wonjin Woo and Eunji Lee and Hyo Jin Park and Yeongun Lee and So Hee Dho and Tae-Kyung Kim and Min-Chan Park and Richard A. Flavell and Lark Kyun Kim}, doi = {10.1002/advs.202505214}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e05214}, shortjournal = {Adv. Sci.}, title = {Targeting eRNA-producing super-enhancers regulates TNFα expression and mitigates chronic inflammation in mice and patient-derived immune cells}, volume = {12}, year = {2025}, }
• (2025). Co-selection of low cadmium accumulation and high yield during tomato improvement. ADVS, 12(39), e05138. (www)

  @article{ , abstract = {Enhancing crop production and yield is necessary to feed an increasing population, but cadmium (Cd) accumulation in crops poses a serious threat to human health. It is found that a trend during domestication is for the co-selection of improved tomato yield and reduced Cd accumulation. A genome-wide association study (GWAS) of 506 tomato accessions identifies a natural allele, LCT1 AA , which confers low Cd accumulation in the shoots and fruits of tomato. The linkage disequilibrium (LD) analysis reveals a tight linkage between LCT1 A and a large fruit allele fw3.2 T . Evolution analysis shows that fw3.2 and LCT1 experience similar selection pressure. Grafting experiments using tomato hypocotyls as the junction point further demonstrate that LCT1 reduces Cd accumulation primarily through regulation in the root rather than the shoot of the plant. These findings collectively highlight the importance of LCT1 in regulating Cd accumulation and indicate that the widespread presence of low Cd accumulating types in cultivated tomato is due to genetic hitchhiking and co-selection of LCT1 A with fw3.2 T during yield breeding}, archive = {J_ADVS}, author = {Xingyu Zhang and Mei Qing and Haobo Xu and Jinbao Tao and Fangman Li and Pingfei Ge and Yang Yang and Wenqian Wang and Yongen Lu and Donald Grierson and Zhibiao Ye and Yuyang Zhang}, doi = {10.1002/advs.202505138}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e05138}, shortjournal = {Adv. Sci.}, title = {Co-selection of low cadmium accumulation and high yield during tomato improvement}, volume = {12}, year = {2025}, }
• (2025). A subcircuit in the suprachiasmatic nucleus generates wakefulness. ADVS, 12(39), e05131. (www)

  @article{ , abstract = {The daily cycles of sleep and arousal are among the most prominent biological rhythms under circadian control. While the role of the suprachiasmatic nucleus (SCN) as the master circadian pacemaker is well-established, the molecular and circuit mechanisms by which it regulates the rhythms of sleep and arousal remain poorly understood. It has previously shown that the Drosophila clock-output molecule Wide Awake (WAKE) and its mammalian homolog mWAKE are expressed in fly clock neurons and dorsomedial hypothalamus neurons that promote arousal. Here, it is investigated whether mWAKE labels an arousal-promoting SCN subcircuit in mice. Broad chemogenetic activation and inhibition of mWAKE + cells lead to a marked increase in wakefulness and a stupor-like phenotype, respectively. Optogenetic activation specifically of mWAKE-expressing neurons in the SCN (SCN mWAKE neurons) promotes arousal, while genetic knockout of mWAKE or impairment of CLOCK function in these neurons enhances wakefulness selectively at night. The latter phenotype corresponds to a specific increase in nighttime spiking of SCN mWAKE neurons in mWake mutants. At the circuit level, SCN mWAKE neuron signaling to the subparaventricular zone (SPZ) yields a stronger arousal phenotype. Together, these findings suggest that the genetic mechanisms regulating circadian control of sleep and arousal are evolutionarily conserved and define a clock-regulated neural network important for rhythmic arousal.}, archive = {J_ADVS}, author = {Qiang Liu and Sang Soo Lee and Jiali Xiong and Shahin Ahmadi and Benjamin J. Bell and Mehmet F. Keles and Mark N. Wu}, doi = {10.1002/advs.202505131}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e05131}, shortjournal = {Adv. Sci.}, title = {A subcircuit in the suprachiasmatic nucleus generates wakefulness}, volume = {12}, year = {2025}, }
• (2025). Robust and reversible supramolecular adhesive via dynamic covalent bond crosslinking-induced assembly of metal-coordinated nanoparticles. ADVS, 12(39), e05122. (www)

  @article{ , abstract = {Supramolecular adhesives, praised for their stimuli-responsiveness and reversibility, have gained significant attention. However, most of these adhesives demonstrate low tolerance to extreme environments and exhibit diminished adhesion performance after cyclic adhesion testing. Herein, a hierarchical self-assembly strategy is introduced for the construction of supramolecular polymer networks (poly(UIO-TA)) through dynamic disulfide bond crosslinking-induced assembly of metal-coordinated nanoparticles (UIO-TA). The UIO-TA were synthesized via a stepwise coordination-driven assembly process, wherein the zirconium ion coordinated with terephthalic acid and thioctic acid. Furthermore, these UIO-TA were crosslinked through ring-opening polymerization of dynamic disulfide bonds, resulting in the formation of poly(UIO-TA). Poly(UIO-TA) exhibited tough, durable, and reversible adhesion on diverse substrates, maintaining its effectiveness under mild to harsh conditions, including high temperatures (120 °C), organic solvents (e.g., dimethyl sulfoxide, ethanol), and strong acids (e.g., sulfuric acid). The adhesion performance of poly(UIO-TA) is superior to poly(thioctic acid) (poly(TA)) and most reported supramolecular adhesives. These attributes can be ascribed to the synergistic interplay of metal coordination bonds, hydrogen bonds, and dynamic disulfide bonds. Notably, after the five-cycle adhesion tests, the adhesion strength of poly(UIO-TA) increased by ≈2.5 times, which can primarily be attributed to increased cohesion energy resulting from the further ring-opening polymerization of disulfide bonds.}, archive = {J_ADVS}, author = {Yanyan Guo and Mengran Zhang and Shuanggen Wu and Xunqiu Wang}, doi = {10.1002/advs.202505122}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e05122}, shortjournal = {Adv. Sci.}, title = {Robust and reversible supramolecular adhesive via dynamic covalent bond crosslinking-induced assembly of metal-coordinated nanoparticles}, volume = {12}, year = {2025}, }
• (2025). Additive manufactured magnetoelectric wireless retainer as the periodontal remodeler for post-orthodontic tissue reconstruction and relapse-inhibition. ADVS, 12(39), e05020. (www)

  @article{ , abstract = {Modern orthodontics since 1899 has failed to solve rapid and persistent dentition maintenance after tooth movement till now. Traditional post-orthodontic retention using single mechanical fixation cannot actuate periodontal tissue remodel, causing lifelong dependence, huge time costs and discomforts. Current attempts by combining hormone drug with mechanical fixation for improvement are limited by unsatisfactory outcomes and global side effects. Targeting at this 120-year dilemma, a flexible magnetoelectric orthodontic retainer (FMOR) is presented using customized additive manufacturing, serving as periodontal remodeler for high-performance post-orthodontic retention. Wireless magnetoelectric cues display considerable effects in periodontal microenvironment remodel, switching periodontal ligament cell (PDLC) paracrine manner to promote M2 macrophage formation, osteoclastic/osteoblastic balance and collagen metabolism. Using rat and rabbit orthodontic model, application of FMOR is confirmed to significantly strengthen the maintaining of tooth movement outcomes. Mechanistically, magnetoelectric treatment significantly upregulate PDLC genes related to immune response, extracellular matrix organization and osteogenic regulation. This study proposes a non-destructive physical therapeutic strategy for fast activation of periodontal reconstruction after orthodontic treatment and inhibition of tooth relapse for the first time, shedding light on development of next-generation orthodontic retention system for optimized solution of orthodontic relapse.}, archive = {J_ADVS}, author = {Haoqi Lei and Jiwei Sun and Peng Chen and Li Hu and Xin Zhou and Shiqiang Gong and Qingming Tang and Xiaoqing Han and Lili Chen and Bin Su}, doi = {10.1002/advs.202505020}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e05020}, shortjournal = {Adv. Sci.}, title = {Additive manufactured magnetoelectric wireless retainer as the periodontal remodeler for post-orthodontic tissue reconstruction and relapse-inhibition}, volume = {12}, year = {2025}, }
• (2025). Viral-directed augmentation of kupffer cell cross-presentation provokes antitumor immunity against liver metastasis. ADVS, 12(39), e04929. (www)

  @article{ , abstract = {Liver metastasis is associated with poor prognosis and resistance to immune checkpoint inhibitors. Functional modulation of Kupffer cells (KCs) holds promise as an alternative immunotherapeutic approach. Leveraging their capacity to capture circulating virions, an oncolytic virus-based KC-targeting strategy is developed that demonstrated efficacy and safety in treating multifocal liver metastasis. A single intravenous infusion of the M51R mutant vesicular stomatitis virus (VSV-M51R), but not wild-type (WT) VSV, induced significant tumor regression in mouse models of forced liver metastasis, independent of direct oncolysis. The ineffectiveness of VSV-WT is attributed to its induction of massive KC apoptosis, whereas VSV-M51R replicated transiently within KCs without compromising viability. Instead, VSV-M51R promoted KC proliferation in tumor-adjacent areas, enhancing their access to tumor foci and cross-presentation of tumor antigens. This led to robust activation of hepatic anti-tumor CD8 + T-cell responses, which required mitochondrial antiviral signaling protein-dependent type I interferon triggering in KCs. Depletion of KCs abolished the T cell stimulating and anti-tumor effects of VSV-M51R. Furthermore, simultaneous blockade of programmed cell death-ligand 1(PD-L1) during VSV-M51R treatment achieved remarkable synergistic efficacy in treating monotherapy-resistant late-stage liver metastasis. These findings underscore the pivotal role of KCs in systemic oncolytic virotherapy and offer a potentially applicable strategy for treating advanced liver metastasis.}, archive = {J_ADVS}, author = {Chen Chen and Qing Zhang and Jiajia Li and Xia Zhou and Daxing Gao and Lu Li and Dabing Huang and Jizhou Wang and Zhutian Zeng}, doi = {10.1002/advs.202504929}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e04929}, shortjournal = {Adv. Sci.}, title = {Viral-directed augmentation of kupffer cell cross-presentation provokes antitumor immunity against liver metastasis}, volume = {12}, year = {2025}, }
• (2025). One-step drug screening system utilizing electrophysiological activity in multiple brain organoids. ADVS, 12(39), e04913. (www)

  @article{ , abstract = {Human-induced pluripotent stem cell (iPSC)-derived brain organoids have attracted significant attention as promising models for drug screening owing to their remarkable resemblance to the human brain. The advent of disease model organoids, derived from patient's cells, has further elevated expectations for drug screening and personalized medicine. Nevertheless, the absence of a comprehensive platform for administering drugs and assessing their efficacy based on functional changes in brain organoids has remained a challenge. In this study, we introduce a one-step drug screening system designed designed to investigate functional changes induced by diverse drug doses in multiple brain organoids, utilizing electrophysiological signal measurements. Our system comprises a specialized culture chamber with a microfluidic chip capable of accommodating 10 organoids and delivering varying doses of two drugs to each organoid. Additionally, we integrate a three dimentional microelectrode array (3D MEA) with ten shanks, enabling functional assessment of 10 brain organoids. This approach facilitates dose-dependent drug screening across multiple organoids. We demonstrate the effectiveness of our system through real-time analysis of neural activity changes triggered by different doses of pottassium chloride (KCl). Furthermore, sodium channel protein type 2 subunit alpha (SCN2A)-epileptic organoids to demonstrate utility in disease-model-based drug screening. Our platform enables functional screening and personalized medicine using brain organoids.}, archive = {J_ADVS}, author = {Hyogeun Shin and Yeonjoo An and Ju-Hyun Lee and Ji Hun Kim and Renuka Prasad and Keun-Tae Kim and Hoon-Chul Kang and Woong Sun and Seung-Woo Cho and Il-Joo Cho}, doi = {10.1002/advs.202504913}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e04913}, shortjournal = {Adv. Sci.}, title = {One-step drug screening system utilizing electrophysiological activity in multiple brain organoids}, volume = {12}, year = {2025}, }
• (2025). Fusidic acid reverses chemoresistance in breast cancer via targeting DDX6 to downregulate GSK-3β/β-catenin signaling. ADVS, 12(39), e04680. (www)

  @article{ , abstract = {ABC transporter protein-mediated drug efflux is a significant contributor to induced resistance in breast cancer (BC). Novel therapies are therefore urgently needed to thwart chemoresistance. Herein, it is demonstrated that fusidic acid (FA) reduces the expression of ABC transporter proteins MRP1, P-gp, and BCRP, promotes the in vivo accumulation of agents, and exertes chemosensitizing effects. Further, DDX6 is identified as a direct target of FA by DARTS and biotin pull-down. Mechanistically, the results indicates that FA directly binds to H378 of DDX6, promotes its degradation, and downregulates its downstream p-GSK-3β, which in turn enhances the phosphorylation and ubiquitin-dependent hydrolysis of β-catenin S33/37/45/T41, blocks pro-resistance β-catenin signaling, and further prevents chemoresistance. The inhibitory effect of FA on chemoresistance is blocked following the knockout of DDX6 using CRISPR/Cas9. More importantly, FA also enhances the interaction between DDX6 and HSC70, while it facilitates DDX6 degradation via chaperone-mediated autophagy (CMA), thereby impairing the GSK-3β/β-catenin axis to enhance the efficacy of FA. Consistently, the effect of FA in combating chemoresistance by targeting DDX6 is evident in a xenograft mouse model. These findings reveal a direct protein target and molecular mechanism for FA to reverse chemoresistance, thus supporting the further development of FA as a chemosensitizing agent.}, archive = {J_ADVS}, author = {Xiaxia Fan and Dan Guo and Songtao Li and Jinmiao Tian and Chaotong Zhang and Zhuoyu Li}, doi = {10.1002/advs.202504680}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e04680}, shortjournal = {Adv. Sci.}, title = {Fusidic acid reverses chemoresistance in breast cancer via targeting DDX6 to downregulate GSK-3β/β-catenin signaling}, volume = {12}, year = {2025}, }
• (2025). Unveiling macrophage content as a predictive biomarker for intraoperative ICG imaging efficacy in lung cancer. ADVS, 12(39), e04498. (www)

  @article{ , abstract = {Due to the phenotypic and genotypic heterogeneity of tumors, the efficacy of intraoperative indocyanine green (ICG) imaging in lung cancer exhibits significant inter-patient variability. This study identifies macrophage content as a critical predictive biomarker for ICG imaging outcomes, offering both mechanistic, and clinical insights into this variability. Mechanistically, macrophages are demonstrated to serve as the principal ICG reservoirs in tumor tissues, exhibiting seven-fold higher uptake capacity compared to cancer cells. This critical role is confirmed by significantly diminished ICG accumulation following macrophage depletion in patient-derived xenograft (PDX) models. Clinically, a strong correlation is observed between imaging quality and macrophage content, with solid nodules exhibiting superior ICG uptake compared to ground-glass nodules due to higher macrophage infiltration. Furthermore, the strong tumor-to-normal ratio (TNR) association with preoperative maximum Standardized Uptake Value (SUVmax) on PET-CT suggests the feasibility of predicting ICG-guided surgery outcomes through routine imaging. The substantial contribution of macrophages to this predictive capability is a significant discovery, offering a novel biomarker for patient stratification in ICG-guided surgery. These insights not only deepen our comprehension of the intricate interplay between ICG and the lung cancer microenvironment but also open new avenues for the development of more personalized and precise surgical strategies.}, archive = {J_ADVS}, author = {Yue Yan and Jiahui Mi and Yun Li and Guanchao Jiang and Yimeng Zhang and Yanguo Liu and Hui Zhao and Jianfeng Li and Xing Yang and Jun Wang and Fan Yang and Kezhong Chen and Yiguang Wang and Jian Zhou}, doi = {10.1002/advs.202504498}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e04498}, shortjournal = {Adv. Sci.}, title = {Unveiling macrophage content as a predictive biomarker for intraoperative ICG imaging efficacy in lung cancer}, volume = {12}, year = {2025}, }
• (2025). Activation of spinal astrocyte α2A adrenoceptors protects against sepsis-induced heart injury through inhibition of GABAergic neuronal necroptosis. ADVS, 12(39), e04406. (www)

  @article{ , abstract = {The peripheral immune system contributes to the development of sepsis-induced cardiomyopathy. However, the underlying mechanisms linking central immune cells and neurons to sepsis-induced cardiomyopathy remain to be clarified. Here, acute sepsis is induced by cecal ligation puncture (CLP), and pharmacological and RNAi interventions are administered to the thoracic spinal cord via intrathecal injection. Echocardiography and histology confirm reduced cardiac function following CLP. Sepsis-induced spinal cord changes involved neuronal activation and loss with decreased gamma-aminobutyric acid (GABA) levels. Necroptosis effector genes are markedly upregulated with increased RIPK1, RIPK3, and MLKL co-expression evident in spinal GABAergic neurons, while administration of the necroptosis inhibitor Necrostatin-1 substantially preserves neurons and reverses sepsis-associated cardiac functional changes. Sepsis triggers increased C3, IL-6 and TNF-α in spinal astrocytes, while administration of the α2A-adrenergic receptor (α2-AR) agonist dexmedetomidine blocked inflammatory factor production, neuronal damage, and cardiac dysfunction. These findings suggest that sepsis-induced cardiomyopathy arises from a neuroimmune interplay involving spinal astrocyte activation, GABAergic neuronal necroptosis, and cardiac damage driven by sympathetic hyperstimulation.}, archive = {J_ADVS}, author = {Ruilin He and Bin Wu and Liuhu Han and Mingde Li and Wenli Guo and Jiajing Fu and Bin Mei and Eric R. Gross and Xuesheng Liu and Yao Lu}, doi = {10.1002/advs.202504406}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e04406}, shortjournal = {Adv. Sci.}, title = {Activation of spinal astrocyte α2A adrenoceptors protects against sepsis-induced heart injury through inhibition of GABAergic neuronal necroptosis}, volume = {12}, year = {2025}, }
• (2025). STK25 loss augments anti-PD-1 therapy efficacy by regulating PD-l1 stability in colorectal cancer. ADVS, 12(39), e03891. (www)

  @article{ , abstract = {Tumor immune evasion is intricately linked to malignant tumor progression and contributes to the failure of anti-cancer immunotherapy. Serine/threonine protein kinase 25 (STK25) has been previously implicated in the progression of various neoplastic diseases. However, the function of STK25 in the colorectal cancer (CRC) microenvironment remains unclear. Here, it is demonstrated that STK25 global knockout (STK25 −/− ) mice and STK25-knockout tumor-bearing mice exhibited enhanced effectiveness of anti-PD-1 immunotherapy, which leads to significant tumor suppression with increased recruitment of CD8 + T cells. Mechanistically, STK25 deficiency increased PD-L1 protein levels by regulating PD-L1 K48-linked ubiquitination in a NEDD4-dependent manner. Moreover, CRC patients with low STK25 expression are more responsive to immune checkpoint blockade (ICB) therapy compared to those with high STK25 levels. Taken together, the findings reveal a critical role of STK25 for regulating PD-L1 protein stability in tumor immune evasion, and suggest that targeting STK25 may provide a potential approach to increase sensitivity to the ICB treatment in patients with CRC.}, archive = {J_ADVS}, author = {Xiaowen Qiao and Pu Xing and Hao Hao and Jiangbo Chen and Lin Song and Yifan Hou and Xinying Yang and Kai Weng and Jie Chen and Pin Gao and Tongkun Song and Hong Yang and Tianqi Liu and Yumeng Ran and Bo Chen and Wei Zhao and Jiabo Di and Zaozao Wang and Jun Zhang and Xiangqian Su and Beihai Jiang}, doi = {10.1002/advs.202503891}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e03891}, shortjournal = {Adv. Sci.}, title = {STK25 loss augments anti-PD-1 therapy efficacy by regulating PD-l1 stability in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Electrical manipulation of magnetic domain structure in van der waals ferromagnetic Fe3GaTe2 using ferroelectric PMN-PT single crystal. ADVS, 12(39), e03530. (www)

  @article{ , abstract = {2D van der Waals (vdW) ferromagnets have emerged as promising materials for spintronic applications due to their unique magnetic properties and tunability. Controlling ferromagnetism via external stimuli is critical for both fundamental research and device integration. In particular, modulation of magnetic anisotropy and exchange interactions through strain offers a viable pathway for functional control. Owing to their weak interlayer coupling, vdW ferromagnets exhibit pronounced sensitivity to strain, enabling effective tuning of their magnetic states. In this study, electric-field-induced magnetoelectric coupling is investigated in the above-room-temperature vdW ferromagnet Fe 3 GaTe 2 integrated on a ferroelectric PMN-PT substrate. It is demonstrated that application of an electric field leads to a substantial reduction in coercive force along with dynamic reconfiguration of the magnetic domain structure. These effects are attributed to electric-field-induced modulation of the vdW interlayer gap and enhancement of the Dzyaloshinskii–Moriya interaction. These findings reveal a strong interplay between electric fields and magnetism in vdW systems, offering a viable route toward the development of low-power, multifunctional magnetic devices. This work establishes a foundation for the electric-field control of magnetic properties in vdW ferromagnets and highlights their potential in next-generation spintronic technologies.}, archive = {J_ADVS}, author = {Riku Iimori and Yuta Kodani and Shaojie Hu and Takashi Kimura}, doi = {10.1002/advs.202503530}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e03530}, shortjournal = {Adv. Sci.}, title = {Electrical manipulation of magnetic domain structure in van der waals ferromagnetic Fe3GaTe2 using ferroelectric PMN-PT single crystal}, volume = {12}, year = {2025}, }
• (2025). Asprosin aggravates tubular epithelial cell injury and phenotypic transformation via mitochondrial dynamics disorder mediated by excessive drp1 SUMOylation in diabetic nephropathy mice. ADVS, 12(39), e03259. (www)

  @article{ , abstract = {Epidemiological studies show that some diabetic patients develop end-stage renal dysfunction without significant proteinuria or glomerulopathy, underscoring the role of renal tubular epithelial cell (TEC) impairment in diabetic kidney disease (DKD). However, the primary pathogenic determinants underlying TEC impairment and disease advancement in DKD progression remain unclear. This study reveals that asprosin (ASP) is up-regulated and positively correlated with kidney dysfunction in DKD mice. Moreover, elevated ASP is mainly located in the renal TEC, and negatively impacts TEC. In addition, supraphysiological ASP concentration impairs mitochondrial dynamics and function in both DKD mice and HK2 cells. Mechanistically, ASP promotes Drp1 over-SUMOylation, thus reducing Drp1 degradation and disrupting mitochondrial dynamics homeostasis. However, the mutation of Drp1-SUMOylation modification sites alleviates the mitochondrial dynamics disorder, TEC injury, and phenotypic transformation induced by ASP. Also, it is further elucidated that such a regulatory effect of ASP on the Drp1-SUMOylation modification is fulfilled by modulating PIAS1 or SENP1 (a de-SUMOylation protease). Importantly, either adipose tissue-specific ASP deficiency (ASP −/− ) or ASP antibody (AASP) intervention significantly alleviates the kidney injury and mitochondrial dynamics disorder induced by STZ/HFD. These findings identify ASP as a novel predictor of DKD and offer new therapeutic strategies for DKD prevention and treatment.}, archive = {J_ADVS}, author = {Qianqian Huang and Xiaowei Xiong and Sheng Chen and Yuan Wang and Li Wang and Wentao Liu and Chen Liu and Guohua Zeng and Qiren Huang}, doi = {10.1002/advs.202503259}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e03259}, shortjournal = {Adv. Sci.}, title = {Asprosin aggravates tubular epithelial cell injury and phenotypic transformation via mitochondrial dynamics disorder mediated by excessive drp1 SUMOylation in diabetic nephropathy mice}, volume = {12}, year = {2025}, }
• (2025). Drug delivery technologies for the treatment of age-related macular degeneration. ADVS, 12(39), e03212. (www)

  @article{ , abstract = {Age-related macular degeneration (AMD) is a progressive and degenerative disease affecting the posterior segment of the eye. It currently affects millions of people worldwide, and the gold standard of treatment has remained unchanged for over 20 years. It consists of intravitreal injections of anti-vascular endothelial growth factor (Anti-VEGF), which pose significant challenges to patient compliance primarily due to accessibility issues, fear of injections in the eye, and high cost. In this review, a thorough description of the pathogenesis of AMD and the anatomical barriers is presented that must be considered for the design of newer drug delivery systems for the treatment of AMD. Likewise, a critical evaluation of the most recent research efforts in the literature regarding the treatment of AMD using novel drug delivery technologies is provided. Lastly, currently approved therapeutic agents are reviewed for AMD and provide an insight into the recent surge of biosimilars with an outlook on how future therapeutic approaches to AMD should be developed.}, archive = {J_ADVS}, author = {J Jesus Rodriguez-Cruz and Jessica Cutrufello and Michael Lam and Shreya Nallaparaju and Nicholas A. Peppas}, doi = {10.1002/advs.202503212}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e03212}, shortjournal = {Adv. Sci.}, title = {Drug delivery technologies for the treatment of age-related macular degeneration}, volume = {12}, year = {2025}, }
• (2025). Pectin metabolism influences phloem architecture and flowering time in arabidopsis thaliana. ADVS, 12(39), e02980. (www)

  @article{ , abstract = {Cell wall matrices undergo continuous remodeling during plant growth and development. The methyl- and de-methyl-esterification of pectic homogalacturonan dynamically influence the physicochemical and mechanical properties of cell walls, and consequently regulate organ morphogenesis. Phloem plays a crucial role in the transport of photoassimilates and other organic molecules from source to sink tissues, and the walls of phloem cells are rich in pectins. However, how pectin metabolism orchestrates phloem architecture and function is unclear. This work demonstrates that the methyl-esterification status and subsequent degradation of pectic homogalacturonan affect flowering time by modulating phloem development and transport capacity, which control the transport of a mobile florigen, FLOWERING LOCUS T protein, in the phloem stream. During this process, auxin signaling is stimulated by pectin de-methyl-esterification to influence vasculogenesis. Together, this data provide new insights into the mechanisms by which pectin chemistry is coordinated with auxin signaling to mediate phloem development, long-distance transport and flowering time.}, archive = {J_ADVS}, author = {Qing Zhang and Juan Du and Shuang Hao and Zhengmei Leng and Weiguo Liu and Chengjian Zhao and Yue Yu and Longquan Chen and Charles T. Anderson and Chaowen Xiao}, doi = {10.1002/advs.202502980}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02980}, shortjournal = {Adv. Sci.}, title = {Pectin metabolism influences phloem architecture and flowering time in arabidopsis thaliana}, volume = {12}, year = {2025}, }
• (2025). Observation of magnetic pseudogap behavior in phosphorus-doped silicon. ADVS, 12(39), e02789. (www)

  @article{ , abstract = {The recent discovery of a Kondo condensate in phosphorus-doped silicon (Si:P) presents its significant potential for achieving novel many-body quantum states. Si:P exhibits Kondo condensation, characterized by an energy gap in the electronic density of states, while the precise nature of its magnetic state has yet to be determined. Here, we utilize electron and muon spin resonance (ESR and µ SR) techniques, optical spectroscopy, and specific heat measurements to unravel the magnetic ground state and spin dynamics of Si:P. Both optical and ESR spectroscopy reveal the onset of spin correlations below 150 K. Furthermore, the muon spin relaxation rate exhibits a power-law increase, λ ZF ∼ T −0.26(5) , below T KC ≈ 0.2 K, indicating the emergence of critical spin fluctuations within the Kondo condensate state. Strikingly, the concomitant occurrence of a Bardeen-Cooper-Schrieffer-like charge gap and power-law magnetic fluctuations closely parallels the pseudogap phases observed in doped Mott insulators. These findings evince that the critical spin fluctuations of the Kondo condensate state act as a driving force for pseudogap formation within inhomogeneous Kondo clouds.}, archive = {J_ADVS}, author = {Suheon Lee and Sangeun Cho and Yongcheol Jo and Wonjun Lee and Jae Min Kim and Hong Gu Lee and Yugo Oshima and Taku Matsushita and Hiroki Ikegami and Jonas A. Krieger and Christoper Baines and Thomas J. Hicken and Hubertus Luetkens and Eundeok Mun and Jungseek Hwang and Hyunsik Im and Kwang-Yong Choi}, doi = {10.1002/advs.202502789}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02789}, shortjournal = {Adv. Sci.}, title = {Observation of magnetic pseudogap behavior in phosphorus-doped silicon}, volume = {12}, year = {2025}, }
• (2025). Glucose-responsive PAGR1-regulated skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism. ADVS, 12(39), e02763. (www)

  @article{ , abstract = {Chronic hyperglycemia, a defining feature of type 2 diabetes (T2D) and related metabolic disorders, exacerbates insulin resistance and impairs muscle glucose utilization, contributing to systemic metabolic dysfunction. While skeletal muscle is the primary site for postprandial glucose uptake and plays a pivotal role in maintaining whole-body glucose homeostasis, the molecular mechanisms by which hyperglycemia induces maladaptive responses in muscle remain poorly understood. Here, PAXIP1-associated glutamate-rich protein 1 (PAGR1) is identified as a glucose-responsive regulator in skeletal muscle, whose expression is induced by high glucose levels and modulates systemic glucose homeostasis and hepatic metabolism. Using muscle-specific PAGR1-knockout mice, it is demonstrated that PAGR1 deficiency enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and increases muscle glucose uptake and utilization. Mechanistically, PAGR1 directly activates the expression of TBC1 Domain Family Member 4 (TBC1D4), a RAB GTPase Activating Protein (RabGAP) known to negatively regulate GLUT4 translocation. Importantly, muscle-specific deletion of PAGR1 protects against high-fat-diet-induced insulin resistance and hepatic steatosis. These findings establish PAGR1 as a critical mediator of muscle glucose sensing and utilization, positioning it as a potential target for therapeutic strategies aimed at mitigating glucotoxicity and preventing metabolic diseases such as T2D.}, archive = {J_ADVS}, author = {Chenyun Ding and Yuhuan Jia and Lin Liu and Wen Wang and Danxia Zhou and Zheng Zhou and Likun Yang and Xinyi Chen and Di Chen and Yan Mao and Liwei Xiao and Cai-Zhi Liu and Zhen-Yu Du and Yujing Yin and Qiqi Guo and Zongchao Sun and Kai Ge and Tingting Fu and Hai-Long Piao and Zhenji Gan}, doi = {10.1002/advs.202502763}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02763}, shortjournal = {Adv. Sci.}, title = {Glucose-responsive PAGR1-regulated skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism}, volume = {12}, year = {2025}, }
• (2025). Capsaicin alleviates autophagy-lysosomal dysfunction via PPARA-mediated V-ATPase subunit ATP6V0E1 signaling in 3xTg-AD mice. ADVS, 12(39), e02707. (www)

  @article{ , abstract = {Autophagy-lysosomal pathway deficits contribute to the accumulation of amyloid-β (Aβ), Tau, and lipid droplets in Alzheimer's disease (AD). Capsaicin, a specific agonist of transient receptor potential vanilloid 1 (TRPV1), can improve cognitive function in AD patients, but the detailed mechanism is still unclear. Here, it is revealed that capsaicin ameliorated AD-related pathology by activating peroxisome proliferator-activated receptor alpha (PPARA/PPARα, a key regulator of lipid metabolism) to promote lipid metabolism and reverse autophagy-lysosomal deficits. Molecular mechanism research found that capsaicin significantly activated the PPAR signaling pathway to promote lipid metabolism, with PPARA identified as the key transcription factor. In addition, capsaicin upregulated ATP6V0E1 (V-ATPase V0 complex subunit e1, involved in lysosomal acidification) expression through PPARA, restoring V-ATPase activity. This enhanced lysosomal acidification facilitated lipophagy (autophagic clearance of lipid droplets), while promoting the clearance of Aβ and Tau aggregates via the autophagy-lysosomal pathway. Further, inhibition of ATP6V0E1 and PPARA expression blocked the effect of capsaicin on alleviating AD lipid pathology and cognitive deficits through autophagy-lysosomal flux. Taken together, capsaicin promotes lipid metabolism, reduces lipid deposition, and attenuates AD-related pathologies, while PPARA-ATP6V0E1-V-ATPase signaling mediated autophagy-lysosomal pathway plays a key role in this process.}, archive = {J_ADVS}, author = {Haitao Yu and Jia Chen and Fangzhou Wang and Dongdong Jia and Shuguang Bi and Yuming Mao and Yu-qi Zhang and Tian-long Gao and Liu Yang and Jia-xu Du and Zi-han Zhou and Xi-Chen Zhu and Gao-shang Chai}, doi = {10.1002/advs.202502707}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02707}, shortjournal = {Adv. Sci.}, title = {Capsaicin alleviates autophagy-lysosomal dysfunction via PPARA-mediated V-ATPase subunit ATP6V0E1 signaling in 3xTg-AD mice}, volume = {12}, year = {2025}, }
• (2025). Counterbalancing O-GlcNAcylation and STAT3 phosphorylation in ventral tegmental area dopaminergic neurons mediates behavioral adaptations to acute restraint stress. ADVS, 12(39), e02701. (www)

  @article{ , abstract = {Acute stressors, significant risk factors for mood disorders, increase anxiety and reduce reward sensitivity. However, the underlying neuroadaptive mechanisms remain unclear. Here, it is shown that acute restraint stress upregulates Signal Transducer and Activator of Transcription 3 (STAT3) signaling and O-GlcNAcylation in ventral tegmental area (VTA) dopaminergic (DAergic) neurons. Multi-omics analyses in O-linked N-acetylglucosamine transferase (OGT) conditional knockout (cKO) mice reveal a counterbalancing mechanism between O-GlcNAcylation and STAT3 Ser727 phosphorylation. In vivo fiber-optic recordings and behavioral experiments demonstrate that STAT3 Ser727 phosphorylation mediates the suppression of DAergic neuronal activity and reward sensitivity, as well as the increased anxiety induced by acute restraint stress. Conversely, the upregulation of O-GlcNAcylation in the VTA DAergic neurons prevents these effects. Furthermore, Gabbr2 and Gabrb3 expression is upregulated in the VTA of Ogt cKO mice, whereas the phosphorylation of STAT3 Ser727 in the DAergic neurons is required for the upregulation of Gabbr2 and Gabrb3 induced by acute restraint stress. These findings highlight the dynamic and counterbalancing post-translational modifications occurring in the VTA to maintain dopaminergic and emotional homeostasis, offering new insights into neuronal and behavioral responses to acute stress.}, archive = {J_ADVS}, author = {Mingshuo Shao and Yi Wu and Haiyang Wang and Chenchun Zhang and Ying Zhu and Yan Jiang and Changyou Jiang and Qiumin Le and Xing Liu and Lan Ma and Feifei Wang}, doi = {10.1002/advs.202502701}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02701}, shortjournal = {Adv. Sci.}, title = {Counterbalancing O-GlcNAcylation and STAT3 phosphorylation in ventral tegmental area dopaminergic neurons mediates behavioral adaptations to acute restraint stress}, volume = {12}, year = {2025}, }
• (2025). A blast-resistant NLR gene confers drought resistance by competitively interacting with an e3 ligase to protect phenylalanine ammonia-lyase in rice. ADVS, 12(39), e02662. (www)

  @article{ , abstract = {Drought and diseases represent major challenges to achieve high yield in crops, underscoring the urgent need to explore drought- and disease-resistant genetic resources and breed crop varieties with multi-stress resistance. Here, using a genome-wide association study combined with function analyses, PibH8 , a homologous of the blast resistance gene Pib encoding a nucleotide-binding leucine-rich repeat receptor (NLR) is identified, which plays a crucial role in rice drought resistance. PibH8 interacts with phenylalanine ammonia-lyase OsPAL1, a rate-limiting enzyme in phenylpropanoids biosynthesis pathway in rice. It protects OsPAL1 from degradation by competitively binding to E3 ubiquitin ligase OsFBK16, which facilitates OsPAL1 degradation. This protective mechanism enhances PAL activity, leading to increased lignin and flavonoids content and improved drought resistance. Genetic evidence indicates that PibH8 acts upstream of OsPAL1 in conferring drought resistance. Furthermore, a causal variation in the PibH8 promoter that is associated with drought resistance is identified. Introgression of a superior haplotype, which exhibits high PibH8 expression, into the elite rice variety Kongyu131 significantly improved drought and blast resistance. This research not only elucidates a regulatory mechanism of NLR protein in drought resistance, but also highlights a promising breeding value of PibH8 for simultaneously improving drought and blast resistance.}, archive = {J_ADVS}, author = {Denghao Xiang and Haifu Tu and Yang Yuan and Yilong Yao and Wanwen Liao and Huaijun Wang and Yu Yan and Yao Wang and Yu Chen and Di Liu and Qingya Lv and Haidong He and Honghong Hu and Xuelei Lai and Meng Yuan and Haiyan Xiong and Faming Dong and Lizhong Xiong}, doi = {10.1002/advs.202502662}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02662}, shortjournal = {Adv. Sci.}, title = {A blast-resistant NLR gene confers drought resistance by competitively interacting with an e3 ligase to protect phenylalanine ammonia-lyase in rice}, volume = {12}, year = {2025}, }
• (2025). A novel cultivation system for germ cell proliferation and sustaining whole testicular niche. ADVS, 12(39), e02435. (www)

  @article{ , abstract = {Childhood cancer treatments often impair male fertility due to gonadotoxic effects. While in vitro culture of prepubertal testis tissue offers a potential solution to preserve fertility, producing sufficient sperm remains a major barrier. To address this, we developed a hydrogel microneedle-based culture system, which is used to culture mouse testes from 5 days postpartum (d pp ) and establish a model of ‘whole testicular spermatogonia pool’ (WTSP). This system promotes over fourfold expansion of undifferentiated spermatogonia, compared to declining numbers during in vivo development. Transplantation of WTSP into nude mice doubled spermatids count per tubule compared to conventional whole testes transplantation. Furthermore, in vitro meiosis induction of WTSP significantly enhanced spermatid proportion, thus generating fertile offspring. Using this system, we also cultured the gonads harvested from aborted human male fetuses and observes significant proliferation of spermatogonia. Lastly, it is shown that the cellular states of the WTSP closely resemble those of 5 d pp mouse testes, and the role of EPHA2 in promoting spermatogonia proliferation by activating the PI3K-AKT-mTOR pathway. In conclusion, the WTSP offers a promising method for preserving fertility in prepubertal male cancer patients by maintaining and expanding spermatogonia extracted before treatment.}, archive = {J_ADVS}, author = {Yu Xia and Xiaoxuan Zhang and Bohang Zhang and Minhui Lu and Qing Cheng and Li Liu and Lifang Shi and Yiqiang Cui and Dingdong Chen and Laihua Li and Xuejiang Guo and Jingtao Guo and Jiahao Sha and Yuanjin Zhao and Yan Yuan}, doi = {10.1002/advs.202502435}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02435}, shortjournal = {Adv. Sci.}, title = {A novel cultivation system for germ cell proliferation and sustaining whole testicular niche}, volume = {12}, year = {2025}, }
• (2025). Dual-targeted nanovesicles induced cancer stem-like cell differentiation to sensitize hepatocellular carcinoma radiotherapy. ADVS, 12(39), e02409. (www)

  @article{ , abstract = {Highly plastic cancer stem-like cells (CSCs) in hepatocellular carcinoma (HCC) drive tumor heterogeneity, contributing to radiotherapy failure. Although inducing CSC differentiation is proven effective in leukemia, this approach is shown limited success in solid tumors due to the complex signaling networks that sustain CSC stemness. In this study, the synergistic effect of Pin1 and Notch1 in HCC is identified, which plays a pivotal role in maintaining the aggressiveness of CSCs and promoting radioresistance. Building on this discovery, biomimetic nanovesicles (CALT-GM-NVs) are engineered by infusing tumor cell membranes into liposomes, which exhibit superior binding affinity to CSCs. RNA sequencing reveals that CALT-GM-NVs downregulate oncogenic signaling pathways while upregulating those linked to differentiation and apoptosis. In vivo, CALT-GM-NVs significantly reduced CSC-driven radiotolerance and improved radiotherapy efficacy in both cell line-derived and patient-derived HCC xenograft models. These findings highlight the potential of simultaneously targeting Pin1 and Notch1 to induce CSC differentiation and provide a promising radiosensitizer for improving HCC radiotherapy outcomes.}, archive = {J_ADVS}, author = {Hongmei Cao and Qian Wang and Yanan Niu and Shuxiang Wang and Haixue Jia and Dianyu Wang and Jinjian Liu and Wei Yuan and Lijun Yang and Jianfeng Liu}, doi = {10.1002/advs.202502409}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02409}, shortjournal = {Adv. Sci.}, title = {Dual-targeted nanovesicles induced cancer stem-like cell differentiation to sensitize hepatocellular carcinoma radiotherapy}, volume = {12}, year = {2025}, }
• (2025). De novo design of specific heterotrimeric collagen-like peptides via genetic algorithm. ADVS, 12(39), e02377. (www)

  @article{ , abstract = {Collagen, the most abundant protein by mass in mammals, features a triple-helical structure composed of three intertwined peptide strands. Nonequivalent strands can assemble, forming heterotrimeric structures, which are more prevalent among natural collagens. However, the design and application of heterotrimeric collagen mimetic peptides (CMPs) are constrained by the potential formation of competing compositions and registers, which impede the formation of target assemblies. Herein, a computational protocol is described, GRACE, utilizing a genetic algorithm to reproducibly generate peptide sequences having a strong tendency to self-assemble into heterotrimeric triple helices with high specificity. The approach leverages SCEPTTr1.2, a refined scoring function tailored to estimate CMP stability and structure, as the basis for fitness evaluation. Four sets of peptide sequences generated by the algorithm, including two with bio-relevant integrin-binding motifs, are experimentally synthesized and characterized. All computationally designed peptides are experimentally shown to self-assemble into heterotrimeric triple helices with expected registers having a minimum specificity of 13.5 °C. The study represents a robust method to overcome barriers in heterotrimeric CMP design providing a versatile framework for the fundamental study of collagen as well as engineering collagen-like materials.}, archive = {J_ADVS}, author = {Thi H. Bui and Oluwakamisi Adetunji and Carson C. Cole and Le Tracy Yu and Caroline M. Peterson and Jeffrey D. Hartgerink}, doi = {10.1002/advs.202502377}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02377}, shortjournal = {Adv. Sci.}, title = {De novo design of specific heterotrimeric collagen-like peptides via genetic algorithm}, volume = {12}, year = {2025}, }
• (2025). H2O2-activated serotonin precursor probe for mapping neuronal redox homeostasis reveals 5-HT interactions with neighboring proteins under oxidative stress. ADVS, 12(39), e02360. (www)

  @article{ , abstract = {Serotonin (5-HT) is a critical neurotransmitter that regulates various neurophysiological processes. However, the role of 5-HT under oxidative stress remains largely unexplored. Here, the development of a novel intramolecular charge transfer (ICT)-based fluorescent probe is reported, termed HOP , designed using a tandem sensing and labeling strategy. HOP is selectively activated by hydrogen peroxide (H 2 O 2 ) in neuronal cells undergoing oxidative stress. Upon activation, HOP emits fluorescent signals and covalently cross-links with nearby proteins, which not only anchors it to the local microenvironment to avoid diffusion of the fluorophore, but also simultaneously releases 5-HT in situ. The locally released 5-HT further interacts with nearby functional proteins such as myeloperoxidase (MPO) and sirtuin 1 (SIRT1), as confirmed through mass spectrometry analyses. Furthermore, HOP is employed in high-throughput screening to identify the antioxidant, hesperidin, that is effective in modulating H 2 O 2 levels and 5-HT homeostasis. Additionally, the efficacy of HOP in detecting H 2 O 2 distribution is validated in vivo and ex vivo using epileptic mouse models. This study presents a robust tool for precise imaging of H 2 O 2 in living neuronal systems and for exploring 5-HT-associated protein modifications under oxidative stress, thus providing new avenues for investigating the role of serotonin in neurological disorders, such as epilepsy.}, archive = {J_ADVS}, author = {Yani Liu and Jiwen Yuan and Tuanjie Zhang and Xinyi Cai and Meng Xu and Xueao Wang and Rui Wang and Bing Zhang and Hai-Liang Zhu and Yong Qian}, doi = {10.1002/advs.202502360}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02360}, shortjournal = {Adv. Sci.}, title = {H2O2-activated serotonin precursor probe for mapping neuronal redox homeostasis reveals 5-HT interactions with neighboring proteins under oxidative stress}, volume = {12}, year = {2025}, }
• (2025). Critical role of IL1R2-ENO1 interaction in inhibiting glycolysis-mediated pyroptosis for protection against lethal sepsis. ADVS, 12(39), e02297. (www)

  @article{ , abstract = {Immune cell metabolic reprogramming toward glycolysis is vital for sepsis defense. While interleukin 1 receptor 2 (IL1R2) acts as a decoy receptor for IL1α/β, its potential impact on cell metabolism and death during sepsis remains unclear. This study observed elevated plasma soluble IL1R2 (sIL1R2) levels in septic patients and mice. In pyroptotic macrophages, reduced intracellular IL1R2 expression led to its release extracellularly. Proteomic screening identified enolase 1 (ENO1), a key glycolysis enzyme, as the binding partner of IL1R2 in macrophages. IL1R2 suppresses ENO1 activity to inhibit glycolysis, gasdermin D (GSDMD)-mediated pyroptosis, and inflammation in macrophages. IL1R2-deficient mice exhibited heightened susceptibility to sepsis, with increased inflammation, organ injury, and mortality. Notably, ENO1 inhibition reduced inflammation, organ injury, and improved survival rates in septic mice. The study reveals that IL1R2 interacts with ENO1 to inhibit glycolysis-mediated pyroptosis and inflammation in sepsis, suggesting the IL1R2-ENO1 interaction as a promising therapeutic target of sepsis.}, archive = {J_ADVS}, author = {Chuyi Tan and Han Ma and Jespar Chen and Gaifeng Ma and Alok Jha and Sipin Tan and Yaxi Zhu and Meidong Liu and Ke Liu and Xianzhong Xiao and Monowar Aziz and Huan Chen and Ping Wang and Huali Zhang}, doi = {10.1002/advs.202502297}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02297}, shortjournal = {Adv. Sci.}, title = {Critical role of IL1R2-ENO1 interaction in inhibiting glycolysis-mediated pyroptosis for protection against lethal sepsis}, volume = {12}, year = {2025}, }
• (2025). Weak and tunable Adhesion–Clutch drives rapid cell migration and glioblastoma invasion. ADVS, 12(39), e02074. (www)

  @article{ , abstract = {To move forward, cells must exert backward forces against their surrounding environment. Recent studies have highlighted the importance of integrin-independent forces for cell migration; however, the molecular machinery that exerts forces remains unclear. This study shows that the clutch-linker molecule shootin1 and the cell adhesion molecule L1 transmit the backward force of treadmilling actin filaments to the environment, enabling rapid dendritic cell migration. Notably, shootin1 and L1 transmit weak traction forces, up to ∼100 times weaker than integrin-based forces, by constituting an integrin-independent slippery adhesion–clutch. This adhesion–clutch is tunable in response to the chemoattractant CCL19 and the adhesive ligand laminin, thereby enabling chemotaxis and haptokinesis. Furthermore, aberrant activity of this adhesion–clutch enhances glioblastoma cell invasion. The results show that the weak adhesion–clutch is well-suited for rapid cell migration, without forming strong adhesions that impede cell motility, and provides a potential target for inhibiting abnormal tumor invasion.}, archive = {J_ADVS}, author = {Kentarou Baba and Ami Fukushi-Kumagai and Megumi Morisaki and Ryosuke Takeuchi and Zhize Xiao and Yoshikazu Nagashima and Mizuki Sakai and Yasuna Higashiguchi and Hiroko Katsuno-Kambe and Asako Katsuma and Yoshihiro Ueda and Yuji Kamioka and Daisuke Kawauchi and Tatsuo Kinashi and Yonehiro Kanemura and Naoyuki Inagaki}, doi = {10.1002/advs.202502074}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02074}, shortjournal = {Adv. Sci.}, title = {Weak and tunable Adhesion–Clutch drives rapid cell migration and glioblastoma invasion}, volume = {12}, year = {2025}, }
• (2025). PIEZO1-GPX4 axis mediates mechanical stress-induced vertebral growth plate dysplasia via ferroptosis activation. ADVS, 12(39), e02052. (www)

  @article{ , abstract = {Current scientific consensus acknowledges mechanical stress, particularly compressive loading, as a critical contributor to the pathogenesis of vertebral growth plate disorders (VGPD), though the precise molecular mechanisms remain incompletely understood. This study establishes PIEZO1 as a mechanosensitive ion channel central to compressive stress responses. These findings demonstrate that PIEZO1 upregulation disrupts GPX4 signaling, thereby amplifying ferroptosis in vertebral growth plate chondrocytes and accelerating pathological ossification. Pharmacological inhibition of PIEZO1 effectively attenuated iron overload, mitigated oxidative stress, and suppressed mechanical stress-induced ferroptosis cascades. Notably, both conditional PIEZO1 knockout models (Col2a1-CreERT; Piezo1 flox/flox ) and pharmacological blockade significantly decelerate scoliosis progression. However, osteoporosis emerges as an unintended consequence of systemic PIEZO1 inhibition, likely attributable to its essential role in osteogenic differentiation. To overcome this limitation, a targeted therapeutic strategy employing micro endoscopy-guided hydrogel-mediated delivery of PIEZO1 inhibitors is developed, achieving spatially restricted modulation within vertebral growth plate cartilage. These results position PIEZO1 as a pivotal regulator of VGPD progression through its coordination of the PIEZO1-GPX4-ferroptosis axis. This work not only elucidates a novel mechanobiological pathway underlying growth plate degeneration but also introduces a precision drug delivery platform with translational potential for VGPD management. The micro-endoscopy-assisted hydrogel system represents a paradigm shift in localized treatment of skeletal disorders while circumventing systemic complications.}, archive = {J_ADVS}, author = {Fei Chen and Fushuai Peng and Shuqing Chen and Yukun Du and Jianyi Li and Yuanyuan Fan and Zichen Cui and Guanghui Gu and Han Zhang and Zhensong Jiang and Guodong Wang and Xingzhi Jing and Jun Dong and Tao Li and Yongming Xi}, doi = {10.1002/advs.202502052}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e02052}, shortjournal = {Adv. Sci.}, title = {PIEZO1-GPX4 axis mediates mechanical stress-induced vertebral growth plate dysplasia via ferroptosis activation}, volume = {12}, year = {2025}, }
• (2025). Glycolytic enzyme HK2 phosphorylates nSMase1 to promote astrocytic exosomes biogenesis contributing to acute ischemic stroke injury. ADVS, 12(39), e01894. (www)

  @article{ , abstract = {Stroke represents a significant threat to public health, with insufficient understanding of its pathological mechanisms hindering therapeutic advancements. Exosomes are implicated in both the injury and recovery processes of ischemic stroke. While enhanced glycolysis is linked to exosome biogenesis, its regulatory mechanisms remain largely unexplored. Here, an increase in the number of exosomes within the cerebrospinal fluid (CSF) and plasma in acute ischemic stroke is observed. Hypoxia selectively enhanced the exosomes biogenesis in astrocytes. Through RNAi screening, we identified the glycolytic enzyme hexokinase 2 (HK2) as a key promoter of hypoxia-induced exosomes. HK2 facilitates the formation of intraluminal vesicles (ILVs), the precursors of exosomes, without affecting their degradation in lysosomes. HK2 directly phosphorylates neutral sphingomyelinase 1 (nSMase1), a critical enzyme involved in the lipid biogenesis pathway of exosomes. Moreover, hypoxia-induced astrocytic exosomes disrupt cerebrovascular endothelial tight junction proteins. Astrocyte-specific knockdown of HK2 significantly reduces exosomes release and alleviates brain injury caused by middle cerebral artery occlusion (MCAO). Notably, MCAO markedly increased the phosphorylation of nSMase1, which is effectively abolished by astrocytic HK2 knockdown. In conclusion, this study reveals a non-metabolic role of HK2 in exosomes biogenesis via its protein kinase activity, offering a potential therapeutic target for stroke.}, archive = {J_ADVS}, author = {Chen Chen and YuWei Zhou and LongXiang Sheng and FangYing Mai and YuXuan Ding and ShiRan Hong and JiaXin Wu and JiaKai Pi and GuangMei Yan and YiJun Huang and JingJing Duan and Xuefeng Hua and Wei Yin}, doi = {10.1002/advs.202501894}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e01894}, shortjournal = {Adv. Sci.}, title = {Glycolytic enzyme HK2 phosphorylates nSMase1 to promote astrocytic exosomes biogenesis contributing to acute ischemic stroke injury}, volume = {12}, year = {2025}, }
• (2025). Extracellular LCN2 binding to 24p3R in astrocytes impedes α-synuclein endocytosis in parkinson's disease. ADVS, 12(39), e01694. (www)

  @article{ , abstract = {The spread or transmission of pathologic α-synuclein (α-Syn) is emerging as potentially important driver of Parkinson's disease (PD) pathogenesis. Emerging evidence suggests that astrocytes play an important role in uptake/clearance of extracellular α-Syn. However, underlying mechanisms and molecular entities responsible for uptake/clearance of extracellular α-Syn by astrocytes are not known. Here, it is shown that lipocalin-2 (LCN2) is upregulated in astrocytes of MPTP-treated mice by RNA-Seq analysis and positively correlates with pathologic α-Syn level in α-Syn PFF model. Strikingly, deletion of astrocytic LCN2 significantly prevents the pathologic α-Syn accumulation and neurodegeneration. Moreover, 24p3R as a crucial receptor of α-Syn uptake by astrocytes is identified, as well as an important mediator of α-Syn spread in the brain. 24p3R specifically binds to α-Syn and then mediates α-Syn uptake. LCN2 prevents astrocytic uptake of α-Syn by impeding the binding of 24p3R and α-Syn. The identification of LCN2/24p3R as a key regulator of α-Syn by astrocytes provides a new target for the treatment of PD and related α-synucleinopathies.}, archive = {J_ADVS}, author = {Ying-Ying Jiao and Tian Tian and Zhu Zhu and Lei Cao and Yang Liu and Rui-An Wang and Zhi-Yong Zhou and Cong Wang and Ke-Zhong Zhang and Xiao Lu and Wen-Wei Yun and Ying-Mei Lu and Gang Hu and Ren-Hong Du and Ming Lu}, doi = {10.1002/advs.202501694}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e01694}, shortjournal = {Adv. Sci.}, title = {Extracellular LCN2 binding to 24p3R in astrocytes impedes α-synuclein endocytosis in parkinson's disease}, volume = {12}, year = {2025}, }
• (2025). Ubiquitination-dependent LLGL2 degradation drives colorectal cancer progression via THBS3 mRNA stabilization. ADVS, 12(39), e01656. (www)

  @article{ , abstract = {Colorectal cancer (CRC) is the second most common cause of cancer-related deaths worldwide is highly associated with distant organ metastasis. Lethal(2) giant larvae protein homolog 2 (LLGL2) is often dysregulated in various tumors; however, the pathogenesis of CRC remains unclean. This study highlighted the tumor suppressor function of LLGL2 in CRC. Depleted LLGL2 exhibits the pro-CRC effects. RNA sequencing reveals that LLGL2 suppresses CRC progression by inhibiting the phosphoinositide 3-kinase (PI3K)-protein kinase B (PKB)/Akt pathway. Further analysis using RNA immunoprecipitation sequencing and shotgun mass spectrometry indicated that LLGL2 primarily regulates the stability of thrombospondin 3 ( THBS3) mRNA by interacting with CCR4-NOT transcription complex subunit 1 (CNOT1), thus inactivating the PI3K-Akt pathway. Additionally, MDM2 acts as an upstream modulator of LLGL2 and promotes its degradation via the proteasomal pathway. This novel mechanism reveals potential therapeutic targets for CRC treatment and enhanced the understanding of how CRC progression can be controlled.}, archive = {J_ADVS}, author = {Jiayan Huang and Tiantian Zhang and Huimin Li and Zidan Li and Shuangshuang Yin and Yiman Liu and Chunze Zhang and Yuling Qiu and Haiyang Yu}, doi = {10.1002/advs.202501656}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e01656}, shortjournal = {Adv. Sci.}, title = {Ubiquitination-dependent LLGL2 degradation drives colorectal cancer progression via THBS3 mRNA stabilization}, volume = {12}, year = {2025}, }
• (2025). Targeting IGF1R overcomes armored and cold tumor microenvironment and boosts immune checkpoint blockade in triple-negative breast cancer. ADVS, 12(39), e01341. (www)

  @article{ , abstract = {In the previous study, patients with tumors based on collagen deposition and immunoreactivity are classified and identified the armored & cold subtype as the most treatment-refractory tumor type. Triple-negative breast cancer (TNBC) is the most lethal tumor type globally, making it critical to overcome the armored and cold tumor microenvironment (TME) for effective treatment of these patients. In this study, the transcriptomic collagen activity and immune profiles of cancer patients treated with immune checkpoint blockade (ICB) are analyzed, and found that intratumoral collagen is associated with an unfavorable immunotherapeutic response and T cell exhaustion. Additionally, collagen is shown to regulate IGF1R expression at both transcriptional and post-translational levels via SOX4 and DDR1, respectively. It is also found that IGF1R promotes tumor cell migration and invasion, as well as T cell exhaustion, with these effects mediated through collagen. Moreover, in vivo inhibition of IGF1R reversed the armored & cold TME, thereby enhancing anti-PD-1 therapy. In conclusion, this study identified IGF1R as a novel therapeutic target for the immuno-collagenic subtype, and combining IGF1R inhibition with anti-PD-1 therapy provides a promising foundation for a novel combination immunotherapy regimen for TNBC.}, archive = {J_ADVS}, author = {Mengyun Wan and Jie Mei and Yun Cai and Ji Zhou and Ningyi Xue and Ying Jiang and Yan Zhang and Jingjing Huang and Yichao Zhu}, doi = {10.1002/advs.202501341}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e01341}, shortjournal = {Adv. Sci.}, title = {Targeting IGF1R overcomes armored and cold tumor microenvironment and boosts immune checkpoint blockade in triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). Osteoblast-CD4+ CTL crosstalk mediated by SIRT1/DAAM2 axis prevents age-related bone loss. ADVS, 12(39), e01170. (www)

  @article{ , abstract = {The dynamic production and clearance of senescent osteoblasts affects bone homeostasis and health. However, the relationship between senescent osteoblasts and the immune system remains unclear. Here, a landscape of the interaction between immune cells and osteoblasts through spatial analysis of the bone microenvironment is presented. Sirtuin 1 (SIRT1), a longevity gene, regulates bone mass maintenance through a mechanism involving osteoblast-CD4 + cytotoxic T lymphocyte (CTL) crosstalk. In the osteoblastic niche, SIRT1 promotes the secretion of crucial chemokines, such as C-C motif chemokine ligand 3 (CCL3), C-C motif chemokine ligand 5 (CCL5), and C-X-C motif chemokine ligand 10 (CXCL10), by upregulating dishevelled-associated activator of morphogenesis 2 (DAAM2) through the acetylation of enhancer of zeste homolog 2 (EZH2), activating and recruiting CD4 + CTLs that eliminate senescent osteoblasts in a major histocompatibility complex class II (MHC-II)-dependent manner, slowing the bone ageing process and ameliorating osteoporosis. DAAM2 serves as a pivotal downstream effector for SIRT1 to exert immune-regulatory effects in the bone microenvironment; thus, targeting DAAM2 can treat osteoporosis by increasing CD4 + CTL responses. These results will facilitate the development of customised therapies targeting senescent osteoblasts to maintain bone health.}, archive = {J_ADVS}, author = {Bin Yang and Guofu Zhang and Yizhou Zhu and Jingcheng Wang and Xinmin Feng and Wenyong Fei and Jihang Dai and Le Hu and Yi Zhang and Jun Cai and Binjia Ruan and Yue Jin and Fanhao Wei and Gang Lu and Dongan Wang and Jason Pui Yin Cheung and Graham Ka Hon Shea and Hao Chen and Kelvin Wai Kwok Yeung and Lei Wang and Yongxiang Wang}, doi = {10.1002/advs.202501170}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e01170}, shortjournal = {Adv. Sci.}, title = {Osteoblast-CD4+ CTL crosstalk mediated by SIRT1/DAAM2 axis prevents age-related bone loss}, volume = {12}, year = {2025}, }
• (2025). Citrullination of AKT2 catalyzed by PAD1 facilitates the maintenance of stemness characteristics of ovarian cancer stem-like cells in ovarian cancer. ADVS, 12(39), e01014. (www)

  @article{ , abstract = {The presence of ovarian cancer stem-like cells (OCSLCs) is a crucial driving force for malignant progression, metastasis, and tumor recurrence of ovarian cancer (OC). However, the mechanisms underlying activation and maintenance of OCSLC stemness remain unclear. Here, it is identified an increased expression of peptidylarginine deiminase 1 (PAD1) in OC cells, particularly within the CD133 + subset or cisplatin-resistant cells, which is positively associated with the upregulation of stemness-related markers and maintenance of stemness in OCSLCs. Mechanistically, PAD1 specifically binds to the kinase domain of AKT2 and catalyzes citrullination at R202. Citrullination subsequently promotes AKT2 phosphorylation at S474 and T309, the two critical residues for AKT2 kinase activity. As a major driver of OC malignancy, the activation of AKT2 leads to an increased expression of CCAAT/Enhancer Binding Protein Beta (CEBPβ), thereby promoting CEBPβ enrichment to the promoters of a subset of stemness-related genes. Moreover, PAD1 gene silencing, inhibition of AKT2 citrullination, and AKT2 mutation all decrease the tumor-initiating ability of OC cells both in vitro and in vivo. Importantly, treatment with a PAD1 inhibitor can resensitize cisplatin-resistant OC cells to cisplatin treatment, suggesting that targeting PAD1/AKT2/CEBPβ signaling axis in OCSLCs may be highly effective in preventing OC progression.}, archive = {J_ADVS}, author = {Teng Xue and Xiaoqiu Liu and Chao Song and Shujia Fei and Jian Gu and Yun Han and Jia Xing and Xiaohan Liu and Fei Liang and Paul R Thompson and Xuesen Zhang}, doi = {10.1002/advs.202501014}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e01014}, shortjournal = {Adv. Sci.}, title = {Citrullination of AKT2 catalyzed by PAD1 facilitates the maintenance of stemness characteristics of ovarian cancer stem-like cells in ovarian cancer}, volume = {12}, year = {2025}, }
• (2025). The CXCL10-CXCR3 axis induces tumor-associated neutrophils to interfere with CTLs-mediated antitumor activity in EBV-associated epithelial cancers. ADVS, 12(39), e00950. (www)

  @article{ , abstract = {Although Epstein–Barr virus (EBV)-associated epithelial cancers are categorized as immunologically “hot” tumors, they have unsatisfactory responses to immunotherapy. Increasing evidence has shown that therapeutic failure is due to an immunosuppressive tumor microenvironment established by EBV. In this study, a negative correlation is found between the infiltration of neutrophils and that of cytotoxic T lymphocytes (CTLs) containing granzyme B in EBV-associated epithelial cancers. The CXCL10-CXCR3 axis in EBV-associated epithelial cancer cells controls the extrusion of neutrophil extracellular traps (NETs), which interferes with the antitumor activity of EBV antigen-specific T cells in vitro and in vivo. NETs are positively correlated with the number of dysfunctional CTLs in EBV-associated epithelial cancers, and are confirmed to be an independent prognostic factor for patients with EBV-associated epithelial cancers. In conclusion, these findings reveal a novel mechanism of immunosuppression of tumor-associated neutrophils (TANs) in EBV-associated epithelial cancers. Targeting NETs formation in TANs may be a potential strategy for improving the efficacy of immunotherapy against EBV-associated epithelial cancers.}, archive = {J_ADVS}, author = {Dijun Ouyang and Tong Xiang and Yuanyuan Chen and Mengjia Song and Jingjing Zhao and Hao Chen and Si Li and Lifeng Zhang and Chi Xu and Yan Ren and Yong Tao and Qijing Wang and Jia He and Yongqiang Li and Sisi Xie and Yuanyuan Liu and Yan Wang and Xinyi Yang and Jinqi You and Songzuo Xie and Yingzi Li and Desheng Weng and Qiuzhong Pan and Qi Yang and Jianchuan Xia}, doi = {10.1002/advs.202500950}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e00950}, shortjournal = {Adv. Sci.}, title = {The CXCL10-CXCR3 axis induces tumor-associated neutrophils to interfere with CTLs-mediated antitumor activity in EBV-associated epithelial cancers}, volume = {12}, year = {2025}, }
• (2025). Nanoplasmonic infrared microarray sensor enabling structural protein biomarker-based drug screening for neurodegenerative diseases. ADVS, 12(39), e00320. (www)

  @article{ , abstract = {The misfolding of proteins from native monomers into β-sheet-rich fibrils via oligomers is a key hallmark of neurodegenerative diseases (NDDs). Identifying and screening drugs that inhibit protein aggregation for early disease intervention remains challenging due to the limitations of existing methods. This work introduces a novel nanoplasmonic infrared microarray sensor for label-free and high-throughput drug screening based on structural protein biomarkers in NDDs. The sensor employs 2D arrays of nanoplasmonic units compartmentalized in micropatterned polymeric microwells for high-throughput protein sensing and secondary structural analysis. The flexibility of the on-chip integrated microarray sensor is showcased through ultra-compact 48, 96, and 384 microwell designs, enabling detection from as low as 2 nL of sample volume and with a 100 pg/mL sensitivity in under a minute of in situ measurement. The drug screening capability is validated by assessing multiple drug compounds in a multiplexed manner for their inhibiting effect on aSyn aggregation, an important NDDs protein biomarker. The microarray sensor successfully quantified the secondary structural changes in drug-treated protein samples, detecting both oligomers and fibrils, which the conventional fluorescence-based assays failed to do. Thus, the nanoplasmonic microarray sensor is a promising advancement in the NDDs and pharmaceutical research for drug screening.}, archive = {J_ADVS}, author = {Deepthy Kavungal and Enzo Morro and Senthil T Kumar and Berkay Dagli and Hilal A Lashuel and Hatice Altug}, doi = {10.1002/advs.202500320}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {e00320}, shortjournal = {Adv. Sci.}, title = {Nanoplasmonic infrared microarray sensor enabling structural protein biomarker-based drug screening for neurodegenerative diseases}, volume = {12}, year = {2025}, }
• (2025). Ubiquitination-dependent LLGL2 degradation drives colorectal cancer progression via THBS3 mRNA stabilization (Adv. sci. 39/2025). ADVS, 12(39), 71964. (www)

  @article{ , archive = {J_ADVS}, author = {Jiayan Huang and Tiantian Zhang and Huimin Li and Zidan Li and Shuangshuang Yin and Yiman Liu and Chunze Zhang and Yuling Qiu and Haiyang Yu}, doi = {10.1002/advs.71964}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {71964}, shortjournal = {Adv. Sci.}, title = {Ubiquitination-dependent LLGL2 degradation drives colorectal cancer progression via THBS3 mRNA stabilization (Adv. sci. 39/2025)}, volume = {12}, year = {2025}, }
• (2025). Nanomaterials trigger functional anti-tumoral responses in primary human immune cells (Adv. sci. 39/2025). ADVS, 12(39), 71954. (www)

  @article{ , archive = {J_ADVS}, author = {Vincent Mittelheisser and Olivier Lefebvre and Mainak Banerjee and Shayamita Ghosh and Amandine Dupas and Marie-Charlotte Diringer and Juliette Blumberger and Louis Bochler and Sébastien Harlepp and Annabel Larnicol and Angélique Pichot and Tristan Stemmelen and Anne Molitor and Chloé Moritz and Christine Carapito and Raphaël Carapito and Loïc J. Charbonnière and François Lux and Olivier Tillement and Jacky G. Goetz and Alexandre Detappe}, doi = {10.1002/advs.71954}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {71954}, shortjournal = {Adv. Sci.}, title = {Nanomaterials trigger functional anti-tumoral responses in primary human immune cells (Adv. sci. 39/2025)}, volume = {12}, year = {2025}, }
• (2025). Directed self-assembly of magnetic bioceramic deep inside dentinal tubules may alleviate dental hypersensitivity (Adv. sci. 39/2025). ADVS, 12(39), 71952. (www)

  @article{ , archive = {J_ADVS}, author = {Shanmukh Peddi and Prajwal Hegde and Prannay Reddy and Anaxee Barman and Arnab Barik and Debayan Dasgupta and Ambarish Ghosh}, doi = {10.1002/advs.71952}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {71952}, shortjournal = {Adv. Sci.}, title = {Directed self-assembly of magnetic bioceramic deep inside dentinal tubules may alleviate dental hypersensitivity (Adv. sci. 39/2025)}, volume = {12}, year = {2025}, }
• (2025). In situ structural evolution and activity descriptor of atomically dispersed catalysts during nitrate electroreduction (Adv. sci. 39/2025). ADVS, 12(39), 71951. (www)

  @article{ , archive = {J_ADVS}, author = {Daniel S. Braga and Angus Pedersen and Mohd Riyaz and Jesús Barrio and Alexander Bagger and Itamar T. Neckel and Thiago M. Mariano and Manuel E. G. Winkler and Ifan E. L. Stephens and Maria-Magdalena Titirici and Raphael Nagao}, doi = {10.1002/advs.71951}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {71951}, shortjournal = {Adv. Sci.}, title = {In situ structural evolution and activity descriptor of atomically dispersed catalysts during nitrate electroreduction (Adv. sci. 39/2025)}, volume = {12}, year = {2025}, }
• (2025). Medium-entropy Alloy/Oxide nano composite for high-performing high-temperature CO2 electrolysis with remarkable carbon deposition resistance (Adv. sci. 39/2025). ADVS, 12(39), 71950. (www)

  @article{ , archive = {J_ADVS}, author = {Jun Tong and Haewon Seo and Yunseo Choi and Ji-eun Won and Jinhong Park and Keun Hwa Chae and Jongsup Hong and Hye Jung Chang and Baowen Zhou and Rongchang Cao and Na Ni and Kyung Joong Yoon and Lei Zhu and Zhen Huang}, doi = {10.1002/advs.71950}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {71950}, shortjournal = {Adv. Sci.}, title = {Medium-entropy Alloy/Oxide nano composite for high-performing high-temperature CO2 electrolysis with remarkable carbon deposition resistance (Adv. sci. 39/2025)}, volume = {12}, year = {2025}, }
• (2025). Dynamic eIF3-s6 phase separation switch instructed by m6A modification drives the molting of locusts (Adv. sci. 39/2025). ADVS, 12(39), 71949. (www)

  @article{ , archive = {J_ADVS}, author = {Zhihao Hu and Yu Zhou and Huimin Wang and Yaxi Wu and Rui Han and Shili Liu and Feng Jiang and Xiaojiao Guo and Meiling Yang}, doi = {10.1002/advs.71949}, journal = {Advanced Science}, month = {10}, number = {39}, pages = {71949}, shortjournal = {Adv. Sci.}, title = {Dynamic eIF3-s6 phase separation switch instructed by m6A modification drives the molting of locusts (Adv. sci. 39/2025)}, volume = {12}, year = {2025}, }
• (2025). An apple susceptibility-related LRR receptor-like kinase MdRLKT21 activates plant immunity by hijacking a trans-kingdom fungal microRNA-like RNA. ADVS, 12(38), e17426. (www)

  @article{ , abstract = {Fungal small RNAs (sRNAs) represent a novel class of effector molecules in plant-pathogen interactions. However, understanding of how plants counteract fungal sRNAs-mediated trans-kingdom RNA interference (RNAi) in plant immunity remains limited. In previous study, a milRNA ( Vm -milR1) from Valsa mali can be found to transboundary inhibit the expression of disease-resistance genes MdRLKT1 and MdRLKT2 in apple. In this study, a leucine-rich repeat receptor-like kinase MdRLKT21 is isolated and characterized, and is confirmed to play a negative regulatory role in the basal immune response. Importantly, MdRLKT21 could hijack Vm -milR1 to rescue the suppression of MdRLKT1 and MdRLKT2 , and a similar phenomenon is also observed in the interaction between V. mali and pear trees. Meanwhile, it is demonstrated that MdRLKT21 can interact with and phosphorylate a C3HC4-type RING finger protein MdRFP1, which positively regulates the apple resistance to V. mali infection. What's more, it is found that MdRLKT21 could inhibit the MdRFP1 -mediated immune response, probably by promoting the 26S proteasome-mediated degradation of MdRFP1 in a kinase activity-dependent manner. Taken together, it is proposed that an apple susceptibility-related LRR-RLK competitively binds to fungal sRNA effector and subsequently activates defenses by salvaging the expression of MdRLKT1 and MdRLKT2 and thereby releasing the resistance protein MdRFP1.}, archive = {J_ADVS}, author = {Mingliang Lei and Jian Zhang and Jie Wang and Chengyu Gao and Yanting He and Runze Tian and Hao Feng and Lili Huang}, doi = {10.1002/advs.202417426}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e17426}, shortjournal = {Adv. Sci.}, title = {An apple susceptibility-related LRR receptor-like kinase MdRLKT21 activates plant immunity by hijacking a trans-kingdom fungal microRNA-like RNA}, volume = {12}, year = {2025}, }
• (2025). Discovery of natural compound α-hederin via large-scale screening as a targeted JAK/STAT3 inhibitor for ovarian cancer therapy. ADVS, 12(38), e17278. (www)

  @article{ , abstract = {Chemoresistance and metastasis are key obstacles to successful ovarian cancer (OC) treatment. Here, α-Hederin, a pentacyclic triterpenoid saponin, is identified as a potent and selective dual inhibitor of JAK1/JAK2 with promising therapeutic potential in OC. Integrating transcriptomic analysis, virtual screening, molecular docking, and biochemical validation, it is shown that α-Hederin directly binds the JH1 kinase domains of JAK1 and JAK2, suppressing their activity and downstream STAT3 phosphorylation. α-Hederin inhibits OC cell proliferation, epithelial-mesenchymal transition (EMT), and metastasis in vitro, and suppresses tumor growth and dissemination in multiple mouse models, with minimal systemic toxicity. Mechanistically, α-Hederin blocks STAT3 nuclear translocation and downregulates oncogenic STAT3 targets including MYC, CCND1, and TWIST1. Rescue experiments using the STAT3 agonist Colivelin partially reversed these effects, confirming the JAK/STAT3 axis as a key target. Moreover, α-Hederin synergizes with cisplatin to enhance antitumor efficacy and overcomes platinum resistance in OC cells. Collectively, our findings highlight α-Hederin as a safe and effective natural JAK1/2 inhibitor that suppresses OC progression by targeting the JAK/STAT3 pathway, offering a compelling candidate for future clinical translation.}, archive = {J_ADVS}, author = {Jiayu Wang and Pengzhan He and Cheng Liu and Xin Chen and Yilin Tan and Rui Qu and Yan Zhang and Zhou Li and Tailang Yin and Zhinang Yin}, doi = {10.1002/advs.202417278}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e17278}, shortjournal = {Adv. Sci.}, title = {Discovery of natural compound α-hederin via large-scale screening as a targeted JAK/STAT3 inhibitor for ovarian cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Patterns and processes of genomic evolution inferred from the ten smallest vertebrate genomes. ADVS, 12(38), e17251. (www)

  @article{ , abstract = {Pufferfish exhibit the smallest vertebrate genomes, making them ideal models for investigating evolutionary patterns and processes that affect genome size. While the Takifugu rubripes genome was fully sequenced two decades ago, key evolutionary drivers remain elusive. We sequenced 10 pufferfish genomes and generated 35 transcriptomes and 13 methylomes to understand genomic evolutionary mechanisms. Comparative genomics revealed that transposable element suppression—rather than lineage-specific conserved element loss—primarily underlies genome compaction. This is mediated by reductions in transposon-associated enzymes that limit transposable element propagation and modify DNA repair mechanisms that promote genomic streamlining. Based on resolved phylogeny among nine Takifugu , it is found that introgression drives speciation of T. niphobles and T. oblongus , while long-term linked selection dominates divergence in other species. Positive selection analyses highlighted mechanotransduction pathway genes (integrins, ion channel transport) that are functionally convergent with mammalian lung cell mechanisms, potentially supporting inflation-based anti-predatory strategies. Additionally, positive selection variants in genes that control lineage-specific skin patterning and coloration, which are either selected for or are rewired in regulatory processes, might suggest a role for pigmentation during the rapid speciation of this lineage. This findings shed light on mechanisms enabling extreme vertebrate genome compaction and provide insights for genome engineering applications.}, archive = {J_ADVS}, author = {Kaiqiang Liu and Qian Wang and Ning Wang and Lingfeng Meng and Shuo Li and Hong-Yan Wang and Yuyan Liu and Qian Liu and Yangqing Zhang and Lucas B. Doretto and Mengqi Zhang and Yating Qin and Shanshan Pan and Shenglei Han and Weijing Li and Shanshan Liu and Fengtao Gao and Axel Meyer and Jussi Taipale and Guangyi Fan and Manfred Schartl and Jilin Zhang and Changwei Shao}, doi = {10.1002/advs.202417251}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e17251}, shortjournal = {Adv. Sci.}, title = {Patterns and processes of genomic evolution inferred from the ten smallest vertebrate genomes}, volume = {12}, year = {2025}, }
• (2025). Conductive nanocomposite hydrogels for neural tissue engineering: A systematic scoping review of recent trends. ADVS, 12(38), e16085. (www)

  @article{ , abstract = {Conductive nanocomposite hydrogels (CNHs) represent a promising tool in neural tissue engineering, offering tailored electroactive microenvironments to address the complex challenges of neural repair. This systematic scoping review, conducted in accordance with PRISMA-ScR guidelines, synthesizes recent advancements in CNH design, functionality, and therapeutic efficacy for central and peripheral nervous system (CNS and PNS) applications. The analysis of 125 studies reveals a growing emphasis on multifunctional materials, with carbon-based nanomaterials (CNTs, graphene derivatives; 36.8%), metals (Iron oxides, gold, etc.; 24.0%), conductive polymers (PEDOT, PPy, etc.; 16.0%), and hybrid systems dominating due to their synergistic electrical, mechanical, and bioactive properties. For CNS repair, spinal cord injury models ( n =  42) leverage antioxidant-conductive hybrids and immunomodulatory systems to mitigate oxidative stress and neuroinflammation. For PNS repair—particularly sciatic nerve regeneration ( n =  20)—CNHs demonstrate efficacy through stimuli-responsive strategies (including wireless and self-powered piezoelectric and magnetic systems) and biomimetic scaffold design to guide axonal regeneration. Tailored hydrogel designs also address traumatic brain injury, stroke, and Parkinson's disease. Beyond these, CNHs show promise in diverse neural tissue engineering contexts, including neurovascular niche reconstruction for diabetic wound healing, coordinated neurogenic and osteogenic differentiation in bone and muscle repair, and auditory neurogenesis in cochlear applications. This review highlights the potential of CNHs by elucidating recent applications across various neural tissue engineering contexts.}, archive = {J_ADVS}, author = {Mohammad Moghaddasi and Busra Oktay and Ayse Betul Bingol and Reyhan Yanikoglu and Meryem Muslu and Ibrahim T Ozbolat and Cem Bulent Ustundag}, doi = {10.1002/advs.202416085}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e16085}, shortjournal = {Adv. Sci.}, title = {Conductive nanocomposite hydrogels for neural tissue engineering: A systematic scoping review of recent trends}, volume = {12}, year = {2025}, }
• (2025). Systematic targeting of GD2-positive neuroblastoma tumors with a photooncolytic phage nanovector platform. ADVS, 12(38), e15356. (www)

  @article{ , abstract = {Disialoganglioside-GD2 is a key molecular target for Neuroblastoma (NB) immunotherapy based on the employment of GD2-targeting antibodies. However, about 50% of treated patients can experience tumor relapse due to limited immune-mediated cytotoxicity and poor antibody penetration into tumors. To address this problem, a tumor-penetrating photo-oncolytic phage nanovector platform is genetically and chemically developed that selectively targets GD2-expressing NB cells. The phage bioconjugates, functionalized with different photosensitizers, result in specific and selective oncolysis of GD2-positive NB cells upon light irradiation, without affecting GD2-negative ones. The photo-oncolytic phage vectors are shown to deeply penetrate into GD2-positive tumor spheroids in vitro, and to cross biological barriers in a zebrafish xenograft model, maintaining their ablation specificity upon irradiation. Finally, to overcome resistance from GD2 loss, often linked to poor prognosis, a CRISPRa strategy is introduced to reactivate GD2 expression in GD2-negative cells. The approach offers a minimally invasive and highly effective strategy, addressing unmet needs in NB therapy.}, archive = {J_ADVS}, author = {Suleman Khan Zadran and Nicola Facchinello and Piergiuseppe De Rosa and Roberto Saporetti and Paolo Emidio Costantini and Luca Ulfo and Michela Nigro and Annapaola Petrosino and Lucia Pappagallo and Sara Aloisi and Giorgio Milazzo and Zainul Abe Din and Alberto Rigamonti and Leonardo Flora and Martina Santulli and Leonardo Cimadom and Giampaolo Zuccheri and Mattia Zangoli and Manuele Di Sante and Matteo Di Giosia and Francesca Di Maria and Roberto Bernardoni and Eveline Barbieri and Matteo Calvaresi and Alberto Danielli and Giovanni Perini}, doi = {10.1002/advs.202415356}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e15356}, shortjournal = {Adv. Sci.}, title = {Systematic targeting of GD2-positive neuroblastoma tumors with a photooncolytic phage nanovector platform}, volume = {12}, year = {2025}, }
• (2025). MCT1-mediated lactate shuttle to mitochondria governs macrophage polarization and modulates glucose homeostasis by affecting β cells. ADVS, 12(38), e14760. (www)

  @article{ , abstract = {As a major fuel source for the tricarboxylic acid cycle, lactate controls energy metabolism through cell-to-cell or tissue-to-tissue lactate shuttles via monocarboxylate transporters (MCTs). Although lactate is shown to influence macrophage functions via histone lactylation, the specific functions of MCTs in macrophages remain incompletely understood. This study discovers that MCT1 and MCT4 have contrasting effects on regulating macrophage polarization. M1 polarization is associated with increase of MCT4 while M2 polarization is accompanied with increase of MCT1. MCT1 is mainly localized in mitochondria while MCT4 is localized on the plasma membrane. M1 polarization elevates lactate efflux from the cytoplasm to extracellular space, while M2 polarization increases intracellular lactate flux to mitochondria. At cellular level, blocking MCT1 exacerbates LPS-induced M1-like polarization and impairs mitochondria function. At animal level, deletion of MCT1 in macrophages exacerbates glucose intolerance, suppresses insulin secretion and increases islet cell death in high-fat diet fed mice. Mechanistically, lactate reduces insulin secretion through GPR81-cAMP-PKA signaling pathway. These findings not only disclose that the MCT1-mediated intracellular lactate shuttle to the mitochondria plays a pivotal role in governing macrophage polarization but also uncovers a functional interplay between macrophages and β cells in maintaining glucose homeostasis.}, archive = {J_ADVS}, author = {Lingling Chen and Yijun Lin and Xinyu Zhu and Shixuan Zhuo and Zixuan Li and Cheng Guo and Xiaoyi Ye and Jinzhu Chen and Shuying Wang and Yan Chen}, doi = {10.1002/advs.202414760}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e14760}, shortjournal = {Adv. Sci.}, title = {MCT1-mediated lactate shuttle to mitochondria governs macrophage polarization and modulates glucose homeostasis by affecting β cells}, volume = {12}, year = {2025}, }
• (2025). Correction to “Fundamentals and applications of dual-frequency magnetic particle spectroscopy: Review for biomedicine and materials characterization”. ADVS, 12(38), e13790. (www)

  @article{ , archive = {J_ADVS}, author = {Hans-Joachim Krause and Ulrich M. Engelmann}, doi = {10.1002/advs.202513790}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e13790}, shortjournal = {Adv. Sci.}, title = {Correction to “Fundamentals and applications of dual-frequency magnetic particle spectroscopy: Review for biomedicine and materials characterization”}, volume = {12}, year = {2025}, }
• (2025). Correction to “TRAF3IP3 induces ER stress-mediated apoptosis with protective autophagy to inhibit lung adenocarcinoma proliferation”. ADVS, 12(38), e13687. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202513687}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e13687}, shortjournal = {Adv. Sci.}, title = {Correction to “TRAF3IP3 induces ER stress-mediated apoptosis with protective autophagy to inhibit lung adenocarcinoma proliferation”}, volume = {12}, year = {2025}, }
• (2025). Epigenetic activation of CCDC183-AS1 promotes osteoclastogenesis and prostate cancer bone metastasis through the FUBP1/LIGHT axis. ADVS, 12(38), e13288. (www)

  @article{ , abstract = {Bone metastasis (BM) is a major contributor to poor prognosis of prostate cancer (PCa); however, the underlying mechanisms of PCa BM remain poorly understood. A better understanding of these processes may provide critical insights for developing effective preventive and therapeutic strategies for PCa BM. In this study, significant upregulation of CCDC183-AS1 in PCa BM is identified, which is associated with disease progression. CCDC183-AS1 overexpression enhanced the ability of PCa cells to spread to the bone by inducing osteoclastogenesis and aiding in the creation of a BM niche. Mechanistically, CCDC183-AS1 interacted with FUBP1 and enhanced its stability by inhibiting JTV-1-mediated ubiquitination and degradation of FUBP1, which promoted the transcription of TNFSF14 (LIGHT). Copy number gain-induced upregulation of KDM5C epigenetically enhanced CCDC183-AS1 expression by recruiting TET1 to its promoter and promoting DNA demethylation. Significantly, the administration of the selective FUBP1 inhibitor, FUBP1-IN-1, is shown to effectively suppress CCDC183-AS1-induced PCa BM. These results shed light on the involvement of CCDC183-AS1 in enhancing osteoclastogenesis and the underlying mechanism in facilitating PCa BM, offering a potential avenue for therapeutic interventions.}, archive = {J_ADVS}, author = {Chuandong Lang and Xiangyu Mu and Kun Chen and Xinwen Wang and Yuluo Rong and Jia Wang and Zongcheng Yang and Chi Yin and Yuhu Dai and Jun Xiao and Wenzhi Zhang}, doi = {10.1002/advs.202413288}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e13288}, shortjournal = {Adv. Sci.}, title = {Epigenetic activation of CCDC183-AS1 promotes osteoclastogenesis and prostate cancer bone metastasis through the FUBP1/LIGHT axis}, volume = {12}, year = {2025}, }
• (2025). Correction to “ZnFe layered double hydroxide nanosheets loaded with cu single-atom nanozymes with multi-enzyme-like catalytic activities as an effective treatment for bacterial keratitis”. ADVS, 12(38), e13019. (www)

  @article{ , archive = {J_ADVS}, author = {Keke Wang and Mao-sen Yuan and Pengxiu Dai and Jing Li and Anju Tao and Xinke Zhang and Jinyi Wang and Qin Tu}, doi = {10.1002/advs.202513019}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e13019}, shortjournal = {Adv. Sci.}, title = {Correction to “ZnFe layered double hydroxide nanosheets loaded with cu single-atom nanozymes with multi-enzyme-like catalytic activities as an effective treatment for bacterial keratitis”}, volume = {12}, year = {2025}, }
• (2025). Design and reprogrammability of zero modes in 2D materials from a single element. ADVS, 12(38), e11227. (www)

  @article{ , abstract = {Mechanical extremal materials, a class of metamaterials that exist at the bounds of elastic theory, possess the extraordinary capability to engineer any desired elastic behavior by harnessing mechanical zero modes — deformation modes that demand minimal or, ideally, no elastic energy. However, the potential for arbitrary construction and reprogramming of metamaterials remains largely unrealized, primarily due to significant challenges in qualitatively transforming zero modes within the confines of existing metamaterial design frameworks. This work presents a method for explicitly defining and in situ reprogramming zero modes of 2D extremal materials by employing straight-line mechanisms (SLMs) and planar symmetry, which prescribe and coordinate the zero modes, respectively. The method is used to design, test, and reprogram centimeter-scale isotropic, orthotropic, and chiral extremal materials by reorienting the SLMs in place, enabling these materials to smoothly and reversibly interpolate between extremal modalities (e.g., unimode to bimode), material properties (e.g., negative to positive Poisson's ratios), and selectively enable chirality without changing the metamaterial's global structure. This methodology provides a straightforward and explicit strategy for the design and tuning of all varieties of 2D extremal materials, enabling dynamic mechanical metamaterial construction to completely cover the gamut of elastic properties.}, archive = {J_ADVS}, author = {Daniel Revier and Molly Carton and Jeffrey I. Lipton}, doi = {10.1002/advs.202511227}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e11227}, shortjournal = {Adv. Sci.}, title = {Design and reprogrammability of zero modes in 2D materials from a single element}, volume = {12}, year = {2025}, }
• (2025). Multifunctional NIR-triggered nanozyme-based microneedles for synergistic eradication of MRSA and enhanced wound healing. ADVS, 12(38), e10774. (www)

  @article{ , abstract = {Antibacterial drug delivery for Methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds faces challenges in reducing oxidative stress, reprogramming the inflammatory microenvironment, and promoting angiogenesis. Herein, a multifunctional near-infrared (NIR) laser-induced nanozymes (CTB) by integrating nitric oxide (NO)-prodrug (BNN6) into a phenolic network of Cu2+-tannic acid. The CTB nanozymes effectively eradicate MRSA through the synergistic effect of NIR-triggered NO release and NIR-induced local hyperthermia. Furthermore, the CTB nanozymes exhibit strong antioxidant, anti-inflammatory, and angiogenic properties. To treat MRSA-infected cutaneous wounds, novel microneedle patches (MN@CTB)are further developed by incorporating CTB nanozymes into hyaluronic acid methacrylate. The MN@CTB successfully eradicates bacterial infections, leveraging the synergistic effects of NO release and NIR-induced local hyperthermia. MN@CTB regulates antioxidative and anti-inflammatory effects by activating the Nrf-2/HO-1 signaling pathways and inhibiting the NF-κB signaling pathway. Additionally, MN@CTB upregulates the expression of soluble guanylate cyclase (sGC), which further activates the protein kinase G (PKG) signaling pathway to stimulate angiogenesis. Proteomic analysis demonstrated the underlying mechanism by which the MN@CTB mainly reprogrammed the infected wound microenvironment by inhibiting the NF-κB signaling pathway and activating the VEGF/TGF-β signaling pathways. It is envisioned that this MN@CTB can work as a highly effective strategy for expediting the healing of MRSA-infected cutaneous wounds.}, archive = {J_ADVS}, author = {Wei Qian and Ruixi Li and Xiyan Zheng and Yingliang Li and Haiwei Xiong and Ye Zhang and Dengliang Lei and Qingfeng Shi and Yufeng Xie and Yiting Zhou and Bailong Tao and Kuai Yu and Aiping Le and Boxuan Zhou}, doi = {10.1002/advs.202510774}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10774}, shortjournal = {Adv. Sci.}, title = {Multifunctional NIR-triggered nanozyme-based microneedles for synergistic eradication of MRSA and enhanced wound healing}, volume = {12}, year = {2025}, }
• (2025). Synthesis of perovskite nanowires and their application for photodetectors. ADVS, 12(38), e10428. (www)

  @article{ , abstract = {1D nanowires (broadly including microwires and quantum wires) of metal halide perovskites exhibit several unique properties due to their distinctive morphology, such as enhanced responsivity under weak light, mechanical flexibility, and optical anisotropy. These perovskite nanowires can be readily fabricated into lateral devices as photoconductive photodetectors. Herein, the synthesis of perovskite nanowires and their applications for photodetectors are primarily focused on, providing an overview of the major synthesis strategies for perovskite nanowires (and arrays) since their initial reports, and analyzing how structural design and modification strategies can improve the performance of nanowire-based devices. The performance of some reported nanowire photodetectors is summarized and analyzed. In addition, the applications for nanowire photodetectors in polarization detection, flexible sensing, and image sensing, followed by a conclusion and outlook are discussed in detail.}, archive = {J_ADVS}, author = {Jiajun Guo and Chenyuan Wang and Xin Zhao and Gangjian Hu and Xinren Zhang and Jizhong Jiang and Wei Wei and Liang Shen}, doi = {10.1002/advs.202510428}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10428}, shortjournal = {Adv. Sci.}, title = {Synthesis of perovskite nanowires and their application for photodetectors}, volume = {12}, year = {2025}, }
• (2025). Open challenges and opportunities in piezoelectricity for tissue regeneration. ADVS, 12(38), e10349. (www)

  @article{ , abstract = {Emerging piezoelectric biomaterials have demonstrated their huge potential in diverse medical applications, including ultrasound diagnosis and tissue regeneration. Human body possesses inherent piezoelectricity, producing electrical signal under endogenous load or external pressure to modulate cellular behaviors. Tissue defects caused by traumatic injury will disrupt the electrophysiological microenvironment of the injured area, resulting in unenviable self-healing. Triggered by physical activities or external stimulation, piezoelectric biomaterials exhibit a unique capability to generate electrical fields to restore the electrophysical microenvironment, reprogram cell fate and ultimately facilitate tissue repair. In this review, endogenous piezoelectric substances in the body and tissue piezoelectricity are introduced. Then, the characteristics and piezoelectricity of piezoelectric biomaterials in regenerative medicine are discussed, as well as strategies to prepare novel piezoelectric composites. Moreover, the molecular mechanisms for the piezoelectric effect on regulating tissue regeneration are systematically summarized. Recent advancements in piezoelectric biomaterials are comprehensively overviewed, including in the regeneration of bone, cartilage, skeletal muscles, tendon, skin, nerve, teeth and periodontal, myocardium, blood vessel and cornea tissues. Finally, the major challenges and future perspectives of piezoelectric biomaterials in regenerative medicine are proposed, hoping to boost the advancement in this promising scientific territory.}, archive = {J_ADVS}, author = {Xiaoling Deng and Yu Zhuang and Jinjie Cui and Liyun Wang and Huilu Zhan and Xudong Wang and Kaili Lin and Changyong Yuan}, doi = {10.1002/advs.202510349}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10349}, shortjournal = {Adv. Sci.}, title = {Open challenges and opportunities in piezoelectricity for tissue regeneration}, volume = {12}, year = {2025}, }
• (2025). Modulation of aging diseases via RAGE targets: A dietary intervention review. ADVS, 12(38), e10242. (www)

  @article{ , abstract = {With the acceleration of global population aging, effective strategies for the prevention and management of aging-related diseases have become increasingly urgent. The receptor for advanced glycation end products (RAGE), a pattern recognition receptor of the immunoglobulin superfamily, plays a central regulatory role in the pathogenesis of chronic conditions such as diabetes and Alzheimer's disease. By binding to a wide range of ligands (e.g., advanced glycation end products, amyloid beta), RAGE activates key inflammatory and stress-related signaling pathways, including NF-κB and MAPK, positioning it as a critical therapeutic target. This review systematically examines RAGE-ligand interactions and their downstream signaling cascades, and proposes targeted intervention strategies. Special emphasis is placed on the regulatory potential of dietary bioactive compounds, such as polyphenols, polysaccharides, and terpenoids, highlighting the distinct advantages of functional foods in anti-aging applications. In line with the World Health Organization's concept of “preventive aging,” dietary-based approaches offer a long-term, safe, and integrative means of providing both nutritional support and disease prevention. This review provides a theoretical foundation for the development of RAGE-targeted dietary interventions and supports a paradigm shift from medical treatment to nutritional prevention in anti-aging strategies.}, archive = {J_ADVS}, author = {Qian Wu and Jia Yan and Yuyan Zhang and Xiaozhi Ming and Siqi Chen and Zhichao Zou and Nianjie Feng and Jianbo Xiao}, doi = {10.1002/advs.202510242}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10242}, shortjournal = {Adv. Sci.}, title = {Modulation of aging diseases via RAGE targets: A dietary intervention review}, volume = {12}, year = {2025}, }
• (2025). Tunable ni-based alloys as electrons donor in dielectric isolated islands to achieve broad frequency electromagnetic wave absorption. ADVS, 12(38), e10198. (www)

  @article{ , abstract = {Nitrogen-doped carbon (NC) nanosheets with tunable electronic features have been considered as effective dielectric materials to tackle the severe electromagnetic pollution. However, it is still a critical issue to reconcile the contradiction between the skin effect originates from the intrinsic high conductivity of NC and the optimal dielectric loss capability. Herein, we prepared NC nanosheets consisting of numerous microdomain to simultaneously achieve good impedance matching and dielectric dissipation performance. The NC surfaces are separated by defect regions into numerous 50–100 nm dielectric isolated islands, while loading ≈40 nm Ni-based alloy nanoparticles (NPs) as tunable electron donating sources. The electron cloud density of the loaded NPs can be tuned by altering the alloy species including NiCo, NiFe and NiMn. NiFe and NiMn NPs with stronger electron donating ability can provide more mobile charges in the isolated islands than that of Ni and NiCo NPs, thereby facilitating the enhancement of electron migration and in-plane interfacial polarization. Consequently, NiFe@NC with better dielectric-magnetic synergy presented a maximum absorption intensity of −101.6 dB with a broadened absorption bandwidth of 10.7 GHz. This work proposes for the first time to effectively tailor the electron cloud density for absorbers utilizing alloying treatment and offers profound insights into dielectric loss mechanisms.}, archive = {J_ADVS}, author = {Pengfei Liu and Da Li and Xiaoguang Zhao and Yanqi Huang and Jingyun Ma and Jiangfang Lian and Shijie Qiu and Zhisen Shen and Zhuan Li and Zhenhui Ma and Song Ma}, doi = {10.1002/advs.202510198}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10198}, shortjournal = {Adv. Sci.}, title = {Tunable ni-based alloys as electrons donor in dielectric isolated islands to achieve broad frequency electromagnetic wave absorption}, volume = {12}, year = {2025}, }
• (2025). An elegant method of one-pot ligation-desulfurization for high-yielding chemical protein synthesis. ADVS, 12(38), e10194. (www)

  @article{ , abstract = {While native chemical ligation (NCL), combined with radical-mediated desulfurization, has enabled chemical syntheses of a vast array of proteins, the presence of aryl thiols as catalysts in the ligation mixture prevents performing both ligation and desulfurization reactions in one-pot, as aryl thiols are effective radical scavengers. Existing one-pot ligation and desulfurization approaches are not ideal as they rely on the use of inefficient alkyl thiols as NCL catalysts. Here an extremely efficient and impressively straightforward method is presented that utilizes bromoacetamide, in conjunction with N-acetyl cysteine, for selective quenching of arylthiol following NCL, enabling ligation and desulfurization in one-pot without any intermediate purification step. The reagent combination facilitates one-pot reactions by selectively capping aryl thiols in the presence of peptidic cysteine residue, leveraging the increased nucleophilicity of aryl thiols over alkyl thiols. N-acetyl cysteine additionally functions as the alkyl thiol additive for the desulfurization reaction. It is demonstrated the utility of this methodology by synthesizing three different proteins: ubiquitin, collagen, and barstar A. The strategy substantially enhances the efficiency of chemical protein synthesis, especially for cysteine-free proteins. Its operational simplicity and broad applicability make this one-pot ligation-desulfurization protocol promising for widespread adoption in synthesizing therapeutic proteins and related biomolecules.}, archive = {J_ADVS}, author = {Vishal Malik and Abhisek Kar and Anandh Muthiah Venkatachalam and Kalyaneswar Mandal}, doi = {10.1002/advs.202510194}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10194}, shortjournal = {Adv. Sci.}, title = {An elegant method of one-pot ligation-desulfurization for high-yielding chemical protein synthesis}, volume = {12}, year = {2025}, }
• (2025). Stimuli-responsive and defect-regulated luminescent organic metal halide for high-security anti-counterfeiting and force sensing. ADVS, 12(38), e10163. (www)

  @article{ , abstract = {Smart materials with stimuli-responsive luminescence hold considerable potential for anti-counterfeiting and sensing applications. However, achieving multimode-responsive luminescence and luminescence modulation remains a significant challenge. Herein, a smart 0D organic metal halide hybrid (OMH) (C 9 NH 20 ) 6 [Pb 3 Br 12 ] exhibiting temperature/moisture/mechanical force-responsive luminescence switching and tunable responsive luminescence color is reported. The heat-activated luminescence switching originates from a crystal structure transformation involving small molecule extraction. The recovery of the transformed structure under cooling and ambient conditions exposure through small molecule reinsertion is highly sensitive to moisture. Interestingly, defects in the recovered structure can be controlled, bringing a pathway to tune the luminescence color. Moreover, 0D (C 9 NH 20 ) 6 [Pb 3 Br 12 ] exhibits self-recovering mechanical force-responsive luminescence switching driven by structure deformation. Based on these stimuli-responsive properties, its applications in time-dependent high-security anti-counterfeiting and handwriting recognition are demonstrated. This study not only provides new insights for designing smart stimuli-responsive luminescent OMH materials but also highlights the potential of (C 9 NH 20 ) 6 [Pb 3 Br 12 ] as a versatile platform for advanced anti-counterfeiting and force sensing applications.}, archive = {J_ADVS}, author = {Chunyan Jiang and Jing Yan and Rongkai Du and Yang Li and Mingmei Wu and Beibei Xu and Jianrong Qiu}, doi = {10.1002/advs.202510163}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10163}, shortjournal = {Adv. Sci.}, title = {Stimuli-responsive and defect-regulated luminescent organic metal halide for high-security anti-counterfeiting and force sensing}, volume = {12}, year = {2025}, }
• (2025). Lutetium-based nanoprobes for radiosensitization with immune microenvironment remodeling and NIR-II fluorescence imaging-guided surgery in colorectal cancer. ADVS, 12(38), e10136. (www)

  @article{ , abstract = {Colorectal cancer (CRC) is among the top five leading cancers worldwide. Preoperative concurrent chemoradiotherapy is recommended for locally advanced CRC. Radiotherapy (RT), a traditional cancer treatment, not only controls local tumor growth but also potentially induces immunogenic cell death, initiating systemic immune responses. Given the poor radiosensitivity of CRC, improving RT sensitization is a critical unmet need. Despite advances in intraoperative imaging, achieving complete resection of colorectal tumors with clear margins in real time remains a significant clinical challenge. This study introduces RVLu@ICG, a novel multifunctional fluorescent nanoprobe emitting in the second near-infrared (NIR-II) range. It's demonstrated that RVLu@ICG has tumor-specific targeting due to modification with cyclic arginine-glycine-aspartic acid (c(RGDfK)) pentapeptide and induces augmented reactive oxygen species (ROS) production under ionizing radiation exposure. This synergistic mechanism not only potentiates radiosensitization efficacy but also facilitates radiation-induced remodeling of the tumor immune microenvironment. Additionally, NIR-II fluorescence image guidance facilitates precise surgical navigation in microtumor models, intramuscular tumor invasion models, and peritoneal metastasis models. Notably, the nanoprobe demonstrates excellent biocompatibility both in vitro and in vivo. Thus, RVLu@ICG establishes a robust precision therapy platform for the treatment of CRC.}, archive = {J_ADVS}, author = {Yongying Dang and Xianzhi Liu and Zifan Zheng and Ao Wang and Ying Huang and Zhong Luo and Haina Tian and Siyaqi Li and Qiang Luo and Peiyuan Wang and Weiling He}, doi = {10.1002/advs.202510136}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10136}, shortjournal = {Adv. Sci.}, title = {Lutetium-based nanoprobes for radiosensitization with immune microenvironment remodeling and NIR-II fluorescence imaging-guided surgery in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). The evolution of functional amyloids and their impact on Host–Microbe interactions. ADVS, 12(38), e10109. (www)

  @article{ , abstract = {Amyloids are highly ordered β-sheet-rich structures that are well conserved across the domains of life. Amyloids have a unique repetitive structure that enables autocatalytic self-replication. This property is most well-known in the context of neurodegeneration, in which proteins misfold into amyloid and begin an amyloid cascade resulting in the deposition of large amyloid aggregates characteristic of various diseases such as Alzheimer's disease and Parkinson's disease. The amyloid fold, however, can be pathological or functional. The repetitive nature of amyloids positions self-replicating amyloids as a potential key player in the origin of life. This may explain why, despite the pathogenic potential of amyloids, the amyloid fold is readily found. Many amyloids are not pathogenic and instead they contribute positively to the overall fitness of the cell. Bacteria, for example, use functional amyloids to facilitate biofilm formation, dissemination, storage, adhesion to cells or surfaces, and virulence. Interestingly, the high conservation of the amyloid fold and its ability to self-replicate enables bacterial functional amyloids to accelerate amyloid-associated disease in a human host. Here, the structure, conservation, and biology of the bacterial functional amyloids, as well as their impact on human health, are discussed.}, archive = {J_ADVS}, author = {Divya Kolli and Saroj K. Rout and Roland Riek and Matthew R. Chapman}, doi = {10.1002/advs.202510109}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10109}, shortjournal = {Adv. Sci.}, title = {The evolution of functional amyloids and their impact on Host–Microbe interactions}, volume = {12}, year = {2025}, }
• (2025). High-performance, strain-stable electromagnetic shielding materials enabled by magnetic elastic fiber networks pinning liquid metal. ADVS, 12(38), e10078. (www)

  @article{ , abstract = {Stretchable electromagnetic interference (EMI) shielding materials are critical for the reliability of wearable electronic devices in complex electromagnetic environments. However, achieving compatibility between ultra-thinness, high shielding efficiency (SE), and excellent dynamic stability remains a major challenge in this field. Here, an ultrathin elastic EMI shielding film (TPU/Fe-LM) is developed by leveraging the magnetoelectric synergy effect and a pinning-interlocking mechanism between ferromagnetic elastic nanofiber networks and the embedded liquid metal (LM), achieving high EMI SE and excellent strain stability. The ultrathin film, with a thickness of 85 µm, exhibits an average EMI SE exceeding 70 dB across a broad frequency range of 0.1 MHz to 40 GHz, with only a 2.59% variation under 100% tensile strain. This superb EMI SE per unit thickness (SSE = 1225 dB mm −1 @ 100% strain) ranks among the highest reported for stretchable EMI shielding films, highlighting the exceptional application potential. As a proof of concept, the EMI shielding film is integrated into a stretchable capacitive strain sensor for dynamic and static force sensing, achieving a 50-fold enhancement in angle resolution for robotic motion monitoring. This research paves the way for stretchable EMI shielding materials and offers valuable guidance for enhancing electromagnetic protection in wearable electronics.}, archive = {J_ADVS}, author = {Qi Zhang and Yuanzhao Wu and Xilai Bao and Shengbin Li and Xueheng Zhuang and Zidong He and Jinyun Liu and Wuxu Zhang and Shiying Li and Feng Xu and Chuibin Zeng and Chao Hu and Qikui Man and Jie Shang and Yiwei Liu and Run-Wei Li}, doi = {10.1002/advs.202510078}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10078}, shortjournal = {Adv. Sci.}, title = {High-performance, strain-stable electromagnetic shielding materials enabled by magnetic elastic fiber networks pinning liquid metal}, volume = {12}, year = {2025}, }
• (2025). High electron charge carrier mobility in the nematic phase of a roof-shaped nematogen with optimum molecular biaxiality. ADVS, 12(38), e10009. (www)

  @article{ , abstract = {A roof-shaped molecule forming exclusively a nematic liquid crystal phase is prepared based on a lead structure. The aspect ratio is designed to be almost optimum with respect to the molecular biaxiality. A broad nematic phase over more than 100 K is observed in which a weak, transient biaxial alignment can be induced under specific thermal and mechanical conditions. In sandwich cells, TOF electron mobilities of up to 2.2 × 10 −2 cm 2 V −1 s −1 are obtained, which are the highest found to date for nematic materials. The latter is attributed to the special self-assembly of the biaxial, roof-shaped mesogens, which favors the contacts between the aromatic units, which is confirmed by X-ray scattering, modeling, and X-ray scattering simulation. The material is responsive to the applied electric field, which results in the anomalous negative field dependence of the charge carrier mobilities.}, archive = {J_ADVS}, author = {Matthias Lehmann and Nikolai Scheuring and Loïc Mager and Dharmendra Pratap Singh and Richard Mandle and Alexey Eremin}, doi = {10.1002/advs.202510009}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e10009}, shortjournal = {Adv. Sci.}, title = {High electron charge carrier mobility in the nematic phase of a roof-shaped nematogen with optimum molecular biaxiality}, volume = {12}, year = {2025}, }
• (2025). Fundamentals and perspectives on materials for bifunctional electrocatalysis. ADVS, 12(38), e09902. (www)

  @article{ , abstract = {Electrocatalysts are the core material for water electrolysis, as a promising technology for green hydrogen production coupled with renewable energy resources. Among various electrocatalyst development strategies, bifunctional electrocatalysts have attracted fast-growing efforts, due to their abilities for catalyzing both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) involved in the electrocatalysis process for reducing the cost in fabrication, operation, and systems. In this study, a comprehensive review of the latest advancements and ongoing research for the bifunctional electrocatalysts uniquely based on their families is presented, aiming to gain deep insights into the field and provide an outlook for the direction of future developments. First, an in-depth discussion is conducted on the mechanisms for both reactions involved in the electrocatalysis process, followed by examining their critical affecting factors. Then, as the heart of this work, a wide range of bifunctional electrocatalyst families are reviewed, including metal–organic frameworks, metal oxide-based catalysts, hydrides and hydroxides, carbon-based materials, phosphides, and chalcogenides. The synergistic effects are also explored for combining different materials through the formation of nanocomposites and heterojunctions. Finally, the challenges encountered with current technologies and perspectives are explored to provide practical and scalable electrocatalyst solutions for water electrolysis.}, archive = {J_ADVS}, author = {Iqra Fareed and Muhammad Danish Khan and Mashal Firdous and Tahmina Maqsood and Masood ul Hassan Farooq and Muhammad Tahir and Faheem K. Butt and Ji-Jun Zou and Shangfeng Du}, doi = {10.1002/advs.202509902}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09902}, shortjournal = {Adv. Sci.}, title = {Fundamentals and perspectives on materials for bifunctional electrocatalysis}, volume = {12}, year = {2025}, }
• (2025). Ultrahigh strength and exceptional work hardening in a hierarchical-structured alloy via hetero-interface-mediated twinning. ADVS, 12(38), e09584. (www)

  @article{ , abstract = {Yield strength and work hardening are two critical mechanical properties of metallic structural materials. However, increasing yield strength through conventional strengthening mechanisms often restricts further dislocation multiplications and interactions, which significantly reduces work hardening and poses a challenge to achieving an optimal balance between these properties in material design. Here, an innovative approach to simultaneously enhance both yield strength and work hardening in a heterostructured, nanoprecipitation-strengthened alloy is reported. This alloy exhibits an exceptional combination of a yield strength exceeding 1.5 GPa and an ultrahigh work hardening rate of 6 GPa, resulting in an extremely high tensile strength of 2.2 GPa and a uniform ductility of 20%. The ultrahigh yield strength primarily stems from nanoprecipitates and ultrafine grains, while the exceptional work hardening mainly originates from hetero-interface-mediated twinning. The hetero-deformation between the coarse-grained and ultrafine-grained regions results in dislocation pile-ups and strain gradients near the interfaces, which provides the ultrahigh stress necessary to activate mechanical twinning, thereby substantially improving the work hardening and plastic deformation stability of the alloy. The hetero-interface architecting strategy can potentially be applied to numerous other alloys, paving the way for designing novel materials with unprecedented mechanical properties for technological applications.}, archive = {J_ADVS}, author = {Yitong Yang and Jingyu Pang and Hongwei Zhang and Jiajia Shen and Zhenqiang Xing and Yuan Sun and Aimin Wang and J. P. Oliveira and Wei Wang and Zengbao Jiao}, doi = {10.1002/advs.202509584}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09584}, shortjournal = {Adv. Sci.}, title = {Ultrahigh strength and exceptional work hardening in a hierarchical-structured alloy via hetero-interface-mediated twinning}, volume = {12}, year = {2025}, }
• (2025). Small stokes shift induced highly efficient and thermally stable broadband near-infrared antimonite double perovskite emitters for spectroscopy applications. ADVS, 12(38), e09583. (www)

  @article{ , abstract = {The exploration of efficient broadband portable near-infrared (NIR) light sources is crucial for next-generation NIR spectroscopy-based technologies. However, developing thermally stable and highly efficient NIR photonic materials exceeding 830 nm is met with limited success. Here, a series of broadband NIR phosphors with long-wavelength emission (λ em > 830 nm) is designed by incorporating activator Cr 3+ ions into ALaMgSbO 6 (A = Ca, Sr) double perovskite matrices. Specifically, a cation site substitution strategy is proposed to reduce the Stokes shift of ALaMgSbO 6 :Cr 3+ (A = Ca, Sr), rendering these as-prepared NIR phosphors possess excellent thermal resistance performance (89.80%@423 K) and high quantum efficiency (82.5%) simultaneously. Structural analyses, DFT calculations, and spectroscopy measurements revealed that Cr 3+ ions can occupy both [SbO 6 ] and [MgO 6 ] polyhedral sites but prefer to replace Sb 5+ ions in ALaMgSbO 6 (A = Ca, Sr). The luminescence efficiency and thermal stability of the samples are further improved through a flux strategy, and the emission spectra are effectively broadened by the introduction of Yb 3+ as an extra NIR emitter. Furthermore, the designed phosphors exhibit a full visible-spectrum conversion ability from 400 to 800 nm, showing great promise for versatile NIR spectroscopy applications in solar energy harvesting, night vision, non-destructive visualization, and dental analysis.}, archive = {J_ADVS}, author = {Zhihao Zhou and Hongjun Jiang and Bozhao Yin and Guocheng Ji and Enhai Song and Jianrong Qiu and Zhongmin Yang and Guoping Dong}, doi = {10.1002/advs.202509583}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09583}, shortjournal = {Adv. Sci.}, title = {Small stokes shift induced highly efficient and thermally stable broadband near-infrared antimonite double perovskite emitters for spectroscopy applications}, volume = {12}, year = {2025}, }
• (2025). Biomolecular interaction prediction: The era of AI. ADVS, 12(38), e09501. (www)

  @article{ , abstract = {Predicting biomolecular interactions is a crucial task in drug discovery and molecular biology. Deep learning, with its ability to learn complex patterns from large datasets, has shown promising results in predicting biomolecular interactions. In this review, a comprehensive and accessible overview of deep learning algorithms is aimed to provide that can enhance the prediction of biomolecular interactions using various features, including sequence data, structural information, and functional annotations. The datasets and models for predicting biomolecular interactions using deep learning are summarized. These deep learning models are developed for a wide range of target molecules, including proteins, nucleic acids, and small molecules, thus reducing the time and cost of screening compounds with high binding affinity to a given target. Furthermore, deep learning can also aid in understanding the mechanisms of biomolecular interactions by identifying key residues involved in the interaction, and help in predicting the side effects of drugs by identifying potential off-target interactions. In conclusion, deep learning has the potential to revolutionize drug discovery and improve understanding of molecular biology by providing accurate and efficient prediction in biomolecular interactions.}, archive = {J_ADVS}, author = {Haoping Wang and Xiangjie Meng and Yang Zhang}, doi = {10.1002/advs.202509501}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09501}, shortjournal = {Adv. Sci.}, title = {Biomolecular interaction prediction: The era of AI}, volume = {12}, year = {2025}, }
• (2025). Superlong-range magnetic coupling and ferromagnetic spin freezing in mechanoluminescent semiconductor Eu:SrAl2O4. ADVS, 12(38), e09474. (www)

  @article{ , abstract = {Magnetic transition in nonmetals requires the presence of a considerable proportion of magnetic spins. A new type of ferromagnet named dilute ferromagnetism that contradicts this well-established concept is proposed for semiconductors of ZnO etc. but has remained experimentally unproven. In this study, an unconventional superlong-range magnetic coupling and ferromagnetic spin freezing are reported, which can be viewed as an experimental realization of an intrinsic dilute ferromagnetism, in mechanoluminescent material of Eu x Sr 1- x Al 2 O 4 ( x = 0.2−2%), wherein Eu is sparsely incorporated into the lattice to substitute Sr. Ferromagnetic coupling appears below ≈80 K and fully saturated ferromagnetic magnetization appears below ≈3 K, with an unusually large magnetic moment of ≈14 µ B per Eu 2+ . Muon spin spectroscopy demonstrates intrinsic spin freezing with a spontaneous internal field developed below T C of ≈3 K. The neighboring magnetic Eu 2+ ions in the lattice have an exceptionally large separation more than one order of magnitude larger than those in conventional magnets, marking it as a unconventional magnetic order over a superlong distance. Bound magnetic polarons arising from electrons trapped at oxygen vacancies may account for this unconventional ferromagnetism. Magnetization under light radiation supports this scenario.}, archive = {J_ADVS}, author = {Xu-Guang Zheng and Ichihiro Yamauchi and Tomasz Galica and Eiji Nishibori and Tatsuya Kawae and Jumpei G. Nakamura and Akihiro Koda and Chao-Nan Xu}, doi = {10.1002/advs.202509474}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09474}, shortjournal = {Adv. Sci.}, title = {Superlong-range magnetic coupling and ferromagnetic spin freezing in mechanoluminescent semiconductor Eu:SrAl2O4}, volume = {12}, year = {2025}, }
• (2025). A charge-adhesive targeted DNA gel bandage for the precision treatment of inflammatory bowel disease. ADVS, 12(38), e09419. (www)

  @article{ , abstract = {The exacerbation and recurrence of inflammatory bowel disease (IBD) are closely related to the overactivation of the immune system and the destruction of the intestinal mucosa. Current small-molecule and biopharmaceutical therapies for IBD are often limited by off-target effects, low bioavailability, and poor treatment outcomes, leading to systemic side effects and severe complications. To address these challenges, DNA gel bandage (DNAgb) designed to block immune cell homing and inhibit inflammatory responses are proposed. DNAgb is a negatively charged “sticky excipient” formed by a rolling circle amplification production hydrogel and an integrin α4 aptamer (ApITGA4) -guided tetrahedral DNA nanostructure. This unique design enables dual-specific localization to inflamed mucosa through electrostatic interactions and ApITGA4-mediated affinity targeting. Our studies have demonstrated that DNAgb exhibits precise targeting, superior stability, and robust anti-inflammatory efficacy. It effectively inhibits activation of the NF-κB signaling pathway, decreases the secretion of inflammatory factors and reshapes the immune microenvironment. Transcriptome analysis further reveals the underlying mechanism of DNAgb in IBD therapy, highlighting its role in inflammation repression. Therefore, DNAgb provides a promising strategy for local therapeutic agents that effectively inhibit the inflammatory response and provides a new and effective choice for the treatment of IBD.}, archive = {J_ADVS}, author = {Peifen Lu and Hongxiu Yuan and Gang Wang and Tao Cheng and Lie Li and Yixi Dong and Runyu Zhao and Xuerui Zhang and Jianwei Jiao and Jin Jiao}, doi = {10.1002/advs.202509419}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09419}, shortjournal = {Adv. Sci.}, title = {A charge-adhesive targeted DNA gel bandage for the precision treatment of inflammatory bowel disease}, volume = {12}, year = {2025}, }
• (2025). Surface-exposed pd nanocluster confined within a ring-shaped polyoxometalate for selective hydrogenation. ADVS, 12(38), e09418. (www)

  @article{ , abstract = {Developing efficient catalysts for selective hydrogenation of molecules bearing multiple reducible functional groups remains a major challenge. Palladium (Pd) nanoclusters are promising candidates owing to their strong H 2 activation ability, broad substrate compatibility, and unique surface properties. However, the controlled synthesis of small Pd nanoclusters with accessible, coordinatively unsaturated active sites remains difficult as they are prone to aggregation. In this study, a strategy is presented to fabricate surface-exposed Pd nanoclusters confined within a ring-shaped polyoxometalate (POM) via a mild solid-state reduction process (1 atm H 2 , ≈25 °C). The resulting Pd nanocluster exhibits exceptional chemoselectivity in the hydrogenation of multifunctional substrates by preferentially adsorbing C═C and C≡C bonds on its discrete, exposed Pd surface with a well-defined coordination environment. Importantly, the rigid POM framework considerably stabilizes Pd nanocluster, enabling excellent reusability over multiple catalytic cycles. This study demonstrates a molecular templating approach for constructing robust and chemoselective metal nanocluster catalysts, offering new opportunities in the design of hydrogenation systems.}, archive = {J_ADVS}, author = {Rui Xi and Kentaro Yonesato and Takafumi Yatabe and Yoshihiro Koizumi and Soichi Kikkawa and Seiji Yamazoe and Koji Harano and Kazuya Yamaguchi and Kosuke Suzuki}, doi = {10.1002/advs.202509418}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09418}, shortjournal = {Adv. Sci.}, title = {Surface-exposed pd nanocluster confined within a ring-shaped polyoxometalate for selective hydrogenation}, volume = {12}, year = {2025}, }
• (2025). Multifunctional metal halide perovskite-modified aqueous electrolytes for zinc metal batteries. ADVS, 12(38), e09417. (www)

  @article{ , abstract = {The performance of Zn metal batteries (ZMBs) is significantly hindered by the poor cycling stability and dendrite growth of Zn metal anodes. Herein, Cs 2 SnCl 6 is introduced, a lead-free metal halide double perovskite, as a multifunctional electrolyte additive to address the challenges of Zn anodes. Utilizing a combination of molecular dynamics simulations, COMSOL simulations, and various characterization techniques, it is demonstrated that Cl − , Sn 4+ , and Cs + ions generated from partial hydrolysis of Cs 2 SnCl 6 in the 2 m ZnSO 4 electrolyte can optimize the electrolyte solvation structures, suppress side reactions, facilitate Zn nucleation process, and modulate Zn deposition behavior. As a result, Zn||Zn symmetric cells with Cs 2 SnCl 6 -enhanced electrolyte achieve remarkable cycling stability over 5000 h at 1 mA cm −2 , while the full cell also shows a capacity retention of 99.96% after 1000 cycles. This work provides insights into electrolyte-driven interface modulation strategies for next-generation aqueous ZMBs.}, archive = {J_ADVS}, author = {Tong Yang and Jiahui Lu and Minh Tam Hoang and Yang Yang and Shijian Wang and Yong Chen and Yongyue Yu and Yan Wang and Timing Fang and Bing Sun and Guoxiu Wang and Hongxia Wang}, doi = {10.1002/advs.202509417}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09417}, shortjournal = {Adv. Sci.}, title = {Multifunctional metal halide perovskite-modified aqueous electrolytes for zinc metal batteries}, volume = {12}, year = {2025}, }
• (2025). Solvent replacement-driven ionic liquid thermoelectric gel for self-powered morse code communication assisted by machine learning. ADVS, 12(38), e09400. (www)

  @article{ , abstract = {The development of ionic liquid gels (IL gels) with both high thermoelectric performance and mechanical flexibility is essential for advancing low-grade heat energy harvesting in next-generation flexible electronics and self-powered systems. Herein, a poly(methacrylic acid) (PMAA)-based IL gel is reported, fabricated via a solvent replacement strategy. By tailoring the synergistic coordination between Fe 2+ /Fe 3+ redox couples and carboxyl (─COOH) groups in the polymer network, the gel functions as a thermogalvanic electrolyte, and its voltage generation is driven by temperature-dependent redox reactions of Fe 2+ /Fe 3+ . The resulting gel demonstrates excellent thermoelectric stability over a broad temperature range, achieving a high ionic conductivity (σ) of 13.45 S·m −1 and the Seebeck coefficient (S i ) of −4.67 mV·K −1 . In situ Raman spectroscopy and low-field solid-state nuclear magnetic resonance (NMR) analysis reveal the directional migration behavior of Fe 2+ /Fe 3+ ions under a thermal gradient and their dynamic coupling with polymer chain motion. Furthermore, a self-powered Morse-code communication system is developed using a machine learning (ML)-assisted framework. A logistic regression model achieved 100% accuracy on an independent test set, indicating a strict monotonic mapping between voltage signals and encoded characters. This work provides new insights into the molecular design and thermoelectric regulation mechanisms of flexible thermoelectric gel, paving the way for their practical application in wearable self-powered communication devices.}, archive = {J_ADVS}, author = {Lingshuang Kong and Fengrui Zhao and Jing Li and Fanlun Meng and Wenlong Xu}, doi = {10.1002/advs.202509400}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09400}, shortjournal = {Adv. Sci.}, title = {Solvent replacement-driven ionic liquid thermoelectric gel for self-powered morse code communication assisted by machine learning}, volume = {12}, year = {2025}, }
• (2025). Efficient exothermic press toward ultrafast and scalable manufacturing of complex polymer composites. ADVS, 12(38), e09336. (www)

  @article{ , abstract = {Rapid and scalable production of high-performance composites remains a key challenge in achieving sustainable manufacturing. Here, Exo-press frontal polymerization (EPFP), a novel and transformative method for manufacturing fiber-reinforced thermoset polymer composites, overcoming energy efficiency, scalability, and curing complex geometries, is introduced. Unlike conventional curing methods that require prolonged processing times and high energy, EPFP utilizes exothermic heat to reduce curing time from hours to minutes with minimal external energy. Combining exothermic heat with press molding, the novel EPFP enables the efficient fabrication of complex geometries, such as airfoil skin sections, with high fiber volume fractions (above 60%). In addition, EPFP is compatible with commercial off-the-shelf epoxy by integrating frontal resin, showcasing its versatility and adaptability for diverse industrial applications. Composites manufactured using EPFP exhibit superior thermomechanical properties while significantly reducing energy consumption by 80% and production costs by 40%. This makes it a sustainable and efficient solution for polymer composites manufacturing.}, archive = {J_ADVS}, author = {Amirreza Tarafdar and Haining Zhang and Xinlu Wang and Andrea J. Hoe and Kaiyue Deng and Kelvin Fu and Quinn Qiao and Ian D. Hosein and Yeqing Wang}, doi = {10.1002/advs.202509336}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09336}, shortjournal = {Adv. Sci.}, title = {Efficient exothermic press toward ultrafast and scalable manufacturing of complex polymer composites}, volume = {12}, year = {2025}, }
• (2025). Metallic bond induces soft phonon mode and anharmonicity in heusler alloy. ADVS, 12(38), e09238. (www)

  @article{ , abstract = {The fruitful functional performances of metastable Heusler alloys originate from the martensitic transformation driven by the transverse acoustic soft phonon mode, regulated by anharmonicity. However, the origins of the soft mode and the anharmonicity in these alloys remain unclear. In this work, using ab-initio calculations combined with self-consistent phonon theory (SCPH) and compressed sensing techniques in machine learning, a link among chemical bonding, long-range interaction, soft mode, and anharmonicity is established using Ni 2 MnGa as a model system. The long-range interaction rooted in metallic bonding between spin-down d -orbitals of Ni─Ni induces phonon softening and significant anharmonicity. This finding offers new insights into the role of metallic bonding and long-range interactions in martensitic transformation, providing a fresh perspective for the design and optimization of phase transition functional alloys.}, archive = {J_ADVS}, author = {Hao-Xuan Liu and Hai-Le Yan and Nan Jia and Bo Yang and Zongbin Li and Xiang Zhao and Liang Zuo}, doi = {10.1002/advs.202509238}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09238}, shortjournal = {Adv. Sci.}, title = {Metallic bond induces soft phonon mode and anharmonicity in heusler alloy}, volume = {12}, year = {2025}, }
• (2025). Regulating enzyme activity via microaggregates mediated by phase separation. ADVS, 12(38), e09209. (www)

  @article{ , abstract = {Liquid–solid phase separation (LSPS) is a biomolecular segregation process forming solid-like aggregates that encapsulate and concentrate specific biomolecules, thus profoundly influencing biochemical reactions. Building on this phenomenon, we developed an enzyme-regulation strategy inducing LSPS of target enzymes to isolate them from substrates. As proof of concept, we created a novel D-Peptide mediated Microaggregate Degradation named DPMD to capture trypsin and chymotrypsin in the seroperitoneum during postoperative pancreatic fistula (POPF). DPMD is designed with cationic and hydrophobic residues and a β-sheet-forming motif for specific binding. The core principle is an entropy-driven peptide self-assembly that sequesters these proteases from the extracellular environment. Captured enzymes form intricate peptide–enzyme microaggregates, effectively segregating them from substrates. These microaggregates are readily internalized and cleared by macrophages, likely via macropinocytosis. In rat POPF models, DPMD significantly reduced pancreatic fluid leakage and inflammatory markers, improved survival, and outperformed a conventional L-peptide control. Toxicity evaluations showed DPMD was well tolerated even at doses beyond therapeutic levels, underscoring its favorable safety profile. In summary, this study demonstrates a significant translational advance in POPF treatment and expands our understanding of pathogenic enzyme sequestration via LSPS, potentially opening new therapeutic avenues for a range of enzyme-mediated diseases.}, archive = {J_ADVS}, author = {Yang Wang and Juzheng Yuan and Niu Dai and Yanlin Ji and Wenguang Yang and Xiao Li and Siqi Yan and Jin Yan}, doi = {10.1002/advs.202509209}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09209}, shortjournal = {Adv. Sci.}, title = {Regulating enzyme activity via microaggregates mediated by phase separation}, volume = {12}, year = {2025}, }
• (2025). Homogeneously-dimensionalizing perovskite surface by dual-mechano-chemical regulation for efficient solar cells. ADVS, 12(38), e09089. (www)

  @article{ , abstract = {Precise manipulation on surface dimensionality benefits the improvement of efficiency and stability of perovskite solar cells, however, heterogeneity with the presence of substantial atomic-scale impurities and micro-wrinkles on perovskite surface that serve as transformation template challenges the formation of homogeneous heterointerface and thus weakens healing efficacy. To address this issue, herein, we propose a dual-mechano-chemical strategy is proposed to homogenize the morphologic-compositional feature of perovskite surface by first polishing superficial nano-impurities with energetic nanoparticles and then in situ dimensionalizing the defect-free lattice to form a 2D/3D heterointerface with strengthened contact and homogeneous distribution. With the implement of this strategy, the reconstructed heterointerface not only accelerates charge transfer with minimized interfacial non-radiative recombination losses, but also protects perovskite lattice from external attack. Consequently, an all-air-processed carbon-based CsPbI 2 Br solar cell displays enhanced efficiency of 15.29% and elevated performance retention rate under dark storage over 1000 h, high temperature over 500 h as well as persistent operation over 200 h. This work provides a multidimensional surface engineering strategy for high-efficiency and stable perovskite-based photoelectric device, benefiting the large-scale fabrication in the future.}, archive = {J_ADVS}, author = {Shengwei Geng and Jialong Duan and Chenlong Zhang and Jinyue Zhang and Yueyang Bi and Yueji Liu and Xixi Zhu and Xinyu Zhang and Qiyao Guo and Jie Dou and Benlin He and Yuanyuan Zhao and Qunwei Tang}, doi = {10.1002/advs.202509089}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e09089}, shortjournal = {Adv. Sci.}, title = {Homogeneously-dimensionalizing perovskite surface by dual-mechano-chemical regulation for efficient solar cells}, volume = {12}, year = {2025}, }
• (2025). Excitation-dependent quadruple-level emission from an isolated molecule for dynamic information encryption. ADVS, 12(38), e08987. (www)

  @article{ , abstract = {Stimuli-responsive single-molecule multi-emission materials have long attracted considerable attention due to their great potential in non-phase-separated smart luminescence. Here, a new strategy is demonstrated for manipulating electron transfer based on donor-acceptor decoupling to regulate energy levels, aiming to achieve excitation-dependent (Ex-De) single-molecule emission with switchable multiple fluorescence and phosphorescence. The synthesized 10-phenyl-10H,13'H-spiro[acridine 9,6'-pentacen]-13'-one (ACRSP) exhibits anti-Kasha quadruple-level emission and opposite Ex-De afterglow in different environments. The high-energy emission bands of multi-fluorescence in solution respond to excitation, whereas in poly(methyl methacrylate) (PMMA), phosphorescence-fluorescence multi-emission causes Ex-De to appear in the low-energy emission band. Experimental and computational results indicate that exciton spin ratios and emissive state compositions vary with excitation modes, leading to dual Ex-De behavior from three fluorescence and one phosphorescence emissions. Donor-acceptor decoupling separates locally excited (LE) and charge transfer (CT) states, while triplet level inversion enables Ex-De behavior and room-temperature phosphorescence (RTP) coexistence (τ = 770.54 ms). By tuning the excitation mode of ACRSP, we achieve Ex-De long afterglow emission from an isolated molecule, enabling time-resolved and excitation-responsive multi-dimensional information encryption. This work offers design guidelines for purely organic Ex-De systems and paves the way for next-generation single-molecule responsive luminophores.}, archive = {J_ADVS}, author = {Yibo Shi and Lin Liu and Wei-Hai Fang and Qian Wang and Xiao Liu and Kai Feng and Wei Sun and Dongpeng Yan and Xuebo Chen}, doi = {10.1002/advs.202508987}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08987}, shortjournal = {Adv. Sci.}, title = {Excitation-dependent quadruple-level emission from an isolated molecule for dynamic information encryption}, volume = {12}, year = {2025}, }
• (2025). Divergent delivery and expression kinetics of lipid and polymeric nanoparticles across mRNA modalities. ADVS, 12(38), e08907. (www)

  @article{ , abstract = {Messenger ribonucleic acid (mRNA)-based therapies, including conventional linear mRNA (linRNA), circular RNA (circRNA), and self-amplifying RNA (saRNA), are being developed not only for vaccination but also for protein replacement, gene editing, and regenerative medicine. However, these mRNA modalities differ in structure and function, and their interactions with current non-viral delivery systems influence their therapeutic efficacy. Here, the in vivo expression kinetics of linRNA, circRNA, and saRNA delivered via lipid nanoparticles (LNPs) or bioreducible poly(cystamine bisacrylamide-co-4-amino-1-butanol) (pABOL) polymer are systematically evaluated. At 0.5 µg, Venezuelan equine encephalitis virus (VEEV)-based saRNA resulted in higher total luciferase expression than 5 µg of linRNA or circRNA highlighting its superior potency. LNPs significantly enhanced expression of non-amplifying mRNAs compared to pABOL, whereas pABOL delivery of saRNA yielded a ∼2-fold improvement over LNPs. Furthermore, saRNAs derived from New World alphaviruses expressed 2–6 times more protein than Old World saRNAs when delivered with LNPs; these differences are not observed with pABOL. These findings demonstrate that mRNA modality, saRNA genotype, and delivery platform interact to determine therapeutic protein output. This study provides actionable insights for optimizing mRNA-based therapeutics across diverse clinical applications.}, archive = {J_ADVS}, author = {Irafasha C. Casmil and Josh J. Friesen and Nuthan V. Bathula and Anneke Strumpel and Chia Hao Ho and Ilana Guez and Kristen Y. S. Kong and Andrew J. Varley and Shigeki J. Miyake-Stoner and Parinaz Aliahmad and Nathaniel S. Wang and Andrew J. Geall and Anna K. Blakney}, doi = {10.1002/advs.202508907}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08907}, shortjournal = {Adv. Sci.}, title = {Divergent delivery and expression kinetics of lipid and polymeric nanoparticles across mRNA modalities}, volume = {12}, year = {2025}, }
• (2025). Non-bonded interaction driven morphology evolution of CuMOF@MXene energetic composites: Synergistic optimization of thermal stability and combustion performance. ADVS, 12(38), e08755. (www)

  @article{ , abstract = {Hybrid materials with tunable properties, particularly metal-organic frameworks (MOFs)@MXene composites have emerged as a cutting-edge research focus different applications. In this study, a novel energetic CuMOF composed of Cu 2+ and 3-(tetrazol-5-yl) triazole is synthesized, followed by the development of CuMOF@MXene composites (CuMOF@MX x ) via a facile one-step hydrothermal method. This approach leverages the interfacial “Ti─O···Cu” non-bonded interactions to achieve composites with diverse morphologies. Subsequently, both experiments and theoretical calculations verify the presence of these non-bonded interactions and their influence on morphology, thermal property, and combustion performance of the composites. The morphologies of composites transition from a flower-like structure to a spherical shape with the addition of Ti 3 C 2 T x MXene. Furthermore, simultaneous thermogravimetry-differential scanning calorimetry tests, along with non-isothermal kinetic analysis, indicate that CuMOF@MX 4 has a higher initial temperature of 354.2 °C for runaway reaction and a larger activation energy of 211.58 kJ mol −1 , compared to CuMOF (314.9 °C and 202.56 kJ mol −1 ). In addition, the combustion tests demonstrate that CuMOF@MX x exhibit more intense and rapid combustion. This work demonstrates the critical role of the non-bonded interaction between CuMOF and Ti 3 C 2 T x interfaces in regulating the structure and properties of the composites, and the possible mechanism of this process is also elucidated.}, archive = {J_ADVS}, author = {Ke-Juan Meng and Xinwen Ma and Kunyu Xiong and Xiaoxia Ma and Iftikhar Hussain and Momang Tian and Kaili Zhang}, doi = {10.1002/advs.202508755}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08755}, shortjournal = {Adv. Sci.}, title = {Non-bonded interaction driven morphology evolution of CuMOF@MXene energetic composites: Synergistic optimization of thermal stability and combustion performance}, volume = {12}, year = {2025}, }
• (2025). Palladium-catalyzed gem-diborylalkylation of silyl enol ethers and N-vinylacetamide via diboryl carbon-centered radicals. ADVS, 12(38), e08566. (www)

  @article{ , abstract = {Herein, a palladium-catalyzed coupling of gem -iododiborylalkanes with electron-rich olefins to access β,β-diboryl ketones and aldehydes under mild conditions is reported. This method exhibits broad substrate scope and excellent functional group tolerance. Mechanistic studies support a distinctive pathway involving gem -diboryl carbon-centered radicals and a Pd(0)/Pd(I) catalytic cycle, without the formation of Pd(II) intermediates. This protocol provides a new platform for accessing synthetically valuable gem -diboryl carbonyl compounds and expands the reactivity profile of organoboron-based radical transformations.}, archive = {J_ADVS}, author = {Xiao-Yu Xie and Yi Wei and Xin-Yi Chen and Ming Li and Kai Hong}, doi = {10.1002/advs.202508566}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08566}, shortjournal = {Adv. Sci.}, title = {Palladium-catalyzed gem-diborylalkylation of silyl enol ethers and N-vinylacetamide via diboryl carbon-centered radicals}, volume = {12}, year = {2025}, }
• (2025). NAD+-boosters improve mitochondria quality control in parkinson's disease models via mitochondrial UPR. ADVS, 12(38), e08503. (www)

  @article{ , abstract = {Serving as a pivotal hub for cellular metabolism and intracellular signaling, the mitochondrion has emerged as a crucial organelle whose dysfunction is linked to many human diseases, including neurodegenerative disorders, particularly Parkinson's disease (PD). However, whether mitochondrial quality control (MQC) can be targeted for therapeutic interventions remains uncertain. This study uses clinical samples, molecular biology techniques, pharmacological interventions, and genetic approaches to investigate the significance of NAD+ levels in cross-species models of PD. These results reveal that treatment of rotenone-incubated cells with NAD+ boosters (such as NMN, siCD38, and NAT) increases UPR mt /mitophagy-related MQC, reduces pro-inflammatory cytokine expression, inhibits apoptosis, and strengthen redox reactions. In vivo, NMN supplementation inhibits motor deficit and forestalls the neuropathological phenotypes of MPTP-induced PD mice, which are required for the atf4 -related mitochondrial UPR pathway. Notably, bulk omics signatures and metabolomic profiling analyses of the striatum reveal NMN-induced transcriptional changes in genes and proteins involved in mitochondrial homeostasis. Thus, these findings demonstrate that the accelerated pathology in PD models is probably mediated by impaired MQC and that bolstering cellular NAD+ levels alleviates mitochondrial proteotoxic stress and mitigate PD phenotypes.}, archive = {J_ADVS}, author = {Shuoting Zhou and Xi Xiong and Jialong Hou and Qi Duan and Yi Zheng and Tao Jiang and Jiani Huang and Haijun He and Jiaxue Xu and Keke Chen and Wenwen Wang and Jinlai Cai and Jingjing Qian and Huijun Chen and Weihong Song and XinShi Wang and Chenglong Xie}, doi = {10.1002/advs.202408503}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08503}, shortjournal = {Adv. Sci.}, title = {NAD+-boosters improve mitochondria quality control in parkinson's disease models via mitochondrial UPR}, volume = {12}, year = {2025}, }
• (2025). SenExo-cCCT2 reprograms senescence response and anti-tumor immunity following FOLFIRINOX chemotherapy in pancreatic ductal adenocarcinoma. ADVS, 12(38), e08431. (www)

  @article{ , abstract = {Combination chemotherapy and immunotherapy have failed to achieve breakthroughs in pancreatic ductal adenocarcinoma (PDAC). Chemotherapy-induced senescence is a potential solution for this problem. This study integrates clinical samples with single-cell transcriptomic sequencing, proteomics, and RNA sequencing and reveals that FOLFIRINOX (a combination regimen of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin) treatment induces a higher proportion of senescent tumor cells (senTCs). This phenomenon is principally attributed to the presence of cCCT2, which inhibits SLX4 condensate-mediated DNA damage repair pathways by regulating small ubiquitin-like modifier conjugation, thereby promoting tumor cell senescence. In the tumor immune microenvironment, cCCT2-overexpressing senTCs exhibit a senescence-associated secretory phenotype (SASP) with preferential secretion of CXCL10, which induces chemotaxis of CD8 + T-cells. Based on the pro-senescence and immune-microenvironment-remodeling effects of cCCT2, an engineered exosome-loaded circRNA system, SenExo-cCCT2 is developed. When combined with SenExo-cCCT2, the FOLFIRINOX regimen enhances the capacity of pancreatic cancer cells to induce senescence. Subsequently, anti-PD-L1 therapy facilitates the immune-mediated clearance of senTCs, markedly improving the therapeutic efficacy of combined chemotherapy and immunotherapy for pancreatic cancer.}, archive = {J_ADVS}, author = {Shuncang Zhu and Yinhao Chen and Hongyi Lin and Jinpeng Lu and Yu Pan and Ge Li and Yongding Wu and Haoxiang Zhang and Xiaoxiao Huang and Yiting Chen and Huangjing Chen and Long Jin and Min Huang and Chengyu Liao and Long Huang and Yifeng Tian and Zuwei Wang and Qiaowei Li and Shi Chen}, doi = {10.1002/advs.202508431}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08431}, shortjournal = {Adv. Sci.}, title = {SenExo-cCCT2 reprograms senescence response and anti-tumor immunity following FOLFIRINOX chemotherapy in pancreatic ductal adenocarcinoma}, volume = {12}, year = {2025}, }
• (2025). Twist grain boundary phases in proper ferroelectric liquid crystals realm. ADVS, 12(38), e08405. (www)

  @article{ , abstract = {The twist-grain-boundary (TGB) phases, characterized by a periodic, helical arrangement of blocks made of polar smectic phases, SmA F and SmC F , have been discovered. They are observed for rod-like molecules with a strong longitudinal dipole moment, featuring an (S)-2-methylbutyl end group having only weak twisting power, and emerge below the antiferroelectric SmA AF phase, where the lamellar structure is already well established. It is suggested that the structure is governed by electrostatic interactions amplified by weak chiral forces, in striking contrast to the mechanism of TGB phase formation found in non-polar materials. The TGB phases exhibit selective light reflection in the visible range, while the value of electric polarization confirms an almost perfectly ordered dipole alignment.}, archive = {J_ADVS}, author = {Damian Pociecha and Jadwiga Szydlowska and Nataša Vaupotič and Katarzyna Kwiatkowska and Marijus Juodka and Julian Spiess and John MD Storey and Corrie T. Imrie and Rebecca Walker and Ewa Gorecka}, doi = {10.1002/advs.202508405}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08405}, shortjournal = {Adv. Sci.}, title = {Twist grain boundary phases in proper ferroelectric liquid crystals realm}, volume = {12}, year = {2025}, }
• (2025). Achieving temperature-insensitive high piezoelectricity by reentrant relaxor transition. ADVS, 12(38), e08293. (www)

  @article{ , abstract = {Although precision sensors and actuators demand piezoelectric materials with temperature-insensitive high piezoelectricity ( d 33 ), achieving such a property is physically challenging because high d 33 relies on tuning the material to the vicinity of a ferroelectric-ferroelectric transition but it renders the property highly temperature-sensitive. This issue is particularly prominent for lead-free materials. Herein, a lead-free Bi-doped (Ba,Ca)(Zr,Ti)TiO 3 ceramic showing a low-temperature reentrant relaxor transition is designed, which is a diffuse transition from a tetragonal ferroelectric to a reentrant relaxor, the latter characterized by orthorhombic (O) polar nanodomains embedded in the tetragonal (T) ferroelectric matrix. The reentrant relaxor composition exhibits a remarkable temperature-insensitive high d 33 of ≈350 pC N −1 over a wide temperature range from -40 to 85 °C. In situ microscopic observations and phase field simulations reveal that the temperature-insensitive high d 33 in the reentrant relaxor composition originates from the synergistic effect between the reduction in the kinetic energy of the T-symmetric ferroelectric domains and the increase in the volume fraction of the O-symmetric nanodomains during cooling. This work provides a new recipe for designing lead-free materials with temperature-insensitive high piezoelectricity.}, archive = {J_ADVS}, author = {Yang Yang and Shichang Li and Liqiang He and Guanqi Wang and Chang Liu and Yiqiao Song and Yuanchao Ji and Hanbing Zhang and Jiantuo Zhao and Dong Wang and Xiaobing Ren}, doi = {10.1002/advs.202508293}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08293}, shortjournal = {Adv. Sci.}, title = {Achieving temperature-insensitive high piezoelectricity by reentrant relaxor transition}, volume = {12}, year = {2025}, }
• (2025). Synthesis of elastic metallic nickel by solvent-ligand-mediated reductive assembly. ADVS, 12(38), e08160. (www)

  @article{ , abstract = {Metallic foams hold significant promise as lightweight structural materials. However, most conventional metallic foams are inherently rigid and brittle, frequently undergoing structural collapse. There is an urgent demand to develop cost-effective, facile-to-synthesize metallic foams with enhanced flexibility. Herein, it is discovered that diethanolamine solvent, a multifunctional organic solvent, not only reduces Ni 2+ ions but also induces the assembly of generated Ni 0 units into 3D metallic nickel (Ni-BPHs) sponges. In addition, the optimization of the binary solvent ratio combined with an acetic acid-assisted method is demonstrated to markedly accelerate the reaction kinetics, concomitant with significantly enhance the coordination density of organic ligands on metallic nickel surface. This approach enables the synthesis of metallic nickel (Ni-BNSs) sponges with enhanced flexibility. The Ni-BPHs and Ni-BNSs as electrocatalysts that exhibit efficient activity and stability for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in alkaline media. The solvent-ligand-mediated reduction and induced assembly strategy has also been demonstrated by extending to other similar ligands. This work marks an important advance in metallic nickel foams and provides a promising strategy for synthesizing mechanically flexible metallic sponges.}, archive = {J_ADVS}, author = {Haiyan An and Guoying Tan and Pingru Su and Yu Long and Deyan He and Yu Tang}, doi = {10.1002/advs.202508160}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08160}, shortjournal = {Adv. Sci.}, title = {Synthesis of elastic metallic nickel by solvent-ligand-mediated reductive assembly}, volume = {12}, year = {2025}, }
• (2025). Cellulosic functional bioplastic with tunable strength and toughness through heat-treatment of dynamic covalent networks. ADVS, 12(38), e08075. (www)

  @article{ , abstract = {The growing environmental crisis caused by petroleum-based polymers has intensified the development of sustainable alternatives, with many biomass-derived polymers demonstrating potential for degradability, renewability, and low carbon footprints, though these properties can vary depending on structure and processing. However, traditional bio-based systems often lack tunability in mechanical properties, making it challenging to achieve both high strength and ductility. Herein, we report a high-performance, recyclable bio-based film (CAF-L) constructed via Diels-Alder dynamic covalent chemistry between furfuryl-functionalized cellulose acetate and maleimide-modified lignin. Thermally responsive dynamic Diels-Alder bonds, activated through heat-treatment, enable programmable network crosslinking that allows a smooth transition between strength- and ductility-dominated regimes, while maintaining high mechanical performance (tensile strength up to 52.3 MPa and elongation at break up to 545%). Structural characterization and molecular simulations reveal that Diels-Alder bond dynamics drive thermally induced structural reorganization of the polymer network, imparting rare adaptivity to biomass-based systems. In addition, CAF-L films exhibit outstanding UV shielding, oxygen barrier properties, and dual-mode recyclability through solvent dissolution and hot pressing. This work provides a scalable platform for constructing mechanically tunable, structurally reconfigurable, and environmentally resilient cellulosic bioplastic for sustainable packaging and circular material systems.}, archive = {J_ADVS}, author = {Xiangyu Tang and Linlin Zhao and Yunfeng Guo and Ying Wang and Zhenke Wei and Xinyan Fan and Zefang Xiao and Haigang Wang and Yanjun Xie and Yonggui Wang}, doi = {10.1002/advs.202508075}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08075}, shortjournal = {Adv. Sci.}, title = {Cellulosic functional bioplastic with tunable strength and toughness through heat-treatment of dynamic covalent networks}, volume = {12}, year = {2025}, }
• (2025). Piezoceramics boosting photocatalytic hydrogen evolution of covalent organic frameworks. ADVS, 12(38), e08062. (www)

  @article{ , abstract = {Precise manipulation of charge-carrier transport dynamics is a pivotal yet challenging attribute in enhancing the efficiency of energy-conversion systems. Herein, piezopotential and optimized energy band alignment are leveraged to construct a core–shell Z -scheme heterostructure, covalently bonding BaTiO 3 nanowires (a piezoelectric ceramic) with TpPa (an imine-linked covalent organic framework). This synergistic combination effectively overcomes the intrinsic limitations of the individual components, particularly in driving photocatalytic water splitting. The resultant Z -scheme heterostructure exhibits a broadened visible-light absorption range, finely tuned energy band alignment, abundant exposure of active sites, and enhanced piezo-driven charge separation, collectively leading to remarkable improvements in charge-carrier transfer and utilization efficiency. As a result, an impressive H 2 evolution rate of 33 mmol g −1 h −1 and an outstanding apparent quantum yield of 9.39% are achieved, representing enhancements of 4.56-fold and 10.06-fold, respectively, compared to pure photocatalysis. This work presents an effective strategy for designing high-efficiency catalysts and highlights the potential of piezoelectricity in boosting photo-redox reactions.}, archive = {J_ADVS}, author = {Jinglin Gao and Jianyu Xiao and Shijia Luo and Xuzheng Ji and Congcong Yin and Yuping Wu and Xin Zhao and Yong Wang}, doi = {10.1002/advs.202508062}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e08062}, shortjournal = {Adv. Sci.}, title = {Piezoceramics boosting photocatalytic hydrogen evolution of covalent organic frameworks}, volume = {12}, year = {2025}, }
• (2025). Helical photonic metamaterials for encrypted chiral holograms. ADVS, 12(38), e07931. (www)

  @article{ , abstract = {Helical structures are among the most quintessential three-dimensional (3D) forms that exhibit mirror asymmetry, a hallmark of chirality. Various structural parameters of helices directly linked to chiroptical properties highlight their importance as essential optical metamaterials for polarization-resolved sensors, imaging, and spectroscopies. However, such function-defining properties remain incompletely understood due to fabrication challenges and the lack of a relationship between structure and optical properties. Here, helical structures are analyzed parametrically, and correlations are established that are applicable to the design of chiral helical optical metamaterials. By systematically varying independent parameters—such as from single-turn to five-turn helices and from small major radii to larger ones optimized to fit the unit cell—the underlying relationships with ellipticty are revealed. In addition to theoretical modeling, the findings are experimentally validated using 3D printing and terahertz spectroscopy. The results demonstrate that optimized helical structures are mechanically tunable and exhibit unprecedented optical properties, including broadband and high-magnitude ellipticity spectra. Being embedded in soft elastomers, helical arrays can serve as soft, stretchable optical-mechanical sensors and holograms containing encoded information, such as barcodes and quick response (QR) codes. Chiral QR codes are realized using pixelated single helices with different handedness, demonstrating their potential as advanced encryption/decryption systems for security applications and chiral metaholograms.}, archive = {J_ADVS}, author = {Wonjin Choi and Widianto P. Moestopo and Songyun Gu and Taeil Lee and Jae-Hyuck Yoo and Xiaoxing Xia and Michael R. Armstrong}, doi = {10.1002/advs.202507931}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07931}, shortjournal = {Adv. Sci.}, title = {Helical photonic metamaterials for encrypted chiral holograms}, volume = {12}, year = {2025}, }
• (2025). Direct sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution unravels their distinct roles in alzheimer's disease. ADVS, 12(38), e07843. (www)

  @article{ , abstract = {Alzheimer's disease (AD) is associated with genetic risk factors and widespread epigenetic alterations. 5-Hydroxymethylcytosine (5hmC), an oxidized derivative of 5-methylcytosine (5mC), constitutes up to 20% of 5mC in neuronal DNA and is implicated in aging and neurodegeneration. However, the precise roles of DNA modifications in AD remain unclear, partly due to the lack of accurate detection methods. Here, two orthogonal sequencing methods are introduced: CMD1-Deaminase sequencing (CD-seq) and CMD1-TET bisulfite sequencing (CT-seq), which enable direct, independent detection of 5mC. When combined with APOBEC-coupled epigenetic sequencing (ACE-seq) or TET-assisted bisulfite sequencing (TAB-seq) for 5hmC mapping, these techniques provide base-resolution, subtraction-free profiling of DNA modifications. Applying them to hippocampal tissue from AD model mice, a significant reduction in 5hmC levels is identified without corresponding changes in 5mC, suggesting that 5hmC functions as an independent epigenetic mark in AD pathogenesis. These findings underscore the importance of precise 5mC/5hmC discrimination and suggest that 5hmC and its regulatory pathways may serve as potential therapeutic targets for AD.}, archive = {J_ADVS}, author = {Zi-Xin Wang and Faying Chen and Bao-Dan He and Fan-Chen Wang and Jiaxue Cha and Yu Song and Wei-Ying Meng and Wan-Yue Zou and Yu-Tao Fu and Shu-Xia Sun and Zhi-Yan Sun and Hao-Ming Jiang and Ke-Yao Zhao and Yujun Hou and Jiejun Shi and Jian-Huang Xue}, doi = {10.1002/advs.202507843}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07843}, shortjournal = {Adv. Sci.}, title = {Direct sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution unravels their distinct roles in alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Time-decoupled electrolysis via a rechargeable metal-urea battery for waste urea treatment and hydrogen production. ADVS, 12(38), e07657. (www)

  @article{ , abstract = {The resource utilization of urea wastewater is an important issue in the environmental field. In the present work, urea can be used as the resource of pure hydrogen production by a temporally decoupled rechargeable metal-urea battery. During the cathodic charging process, urea is dissociated by the reaction of CO(NH 2 ) 2 + 6OH − → N 2 + 5H 2 O + CO 2 + 6e − to achieve the disposal of urea. Water is splitting into hydrogen (2H 2 O + 2e − → H 2 + 2OH − ) during the cathodic discharging process, accompanied with the production of electrochemical energy. The key catalyst layers at the cathode employed bifunctional Ni/Mo 2 C electrocatalysts for both the urea oxidation reaction (UOR) and the hydrogen evolution reaction (HER). The home-made Zn–Urea battery can accomplish continuous hydrogen production with a Faraday efficiency of 99% over 20 h, together with a maximum power density of 3.4 mW cm −2 . The temporally decoupled rechargeable metal-urea battery can convert waste urea into high-value purified hydrogen with partial recovery of electrical energy, offering an impressive resource utilization route for wastewater treatment.}, archive = {J_ADVS}, author = {Dong Lv and Zhengrong Xu and Xingyu Guo and Deng Liu and Rui Liu}, doi = {10.1002/advs.202507657}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07657}, shortjournal = {Adv. Sci.}, title = {Time-decoupled electrolysis via a rechargeable metal-urea battery for waste urea treatment and hydrogen production}, volume = {12}, year = {2025}, }
• (2025). Enhanced cycling stability in zn-ion batteries using aqueous-organic electrolyte solvent blends. ADVS, 12(38), e07332. (www)

  @article{ , abstract = {Zinc-ion batteries (ZIBs) have emerged as a promising candidate for safe and affordable energy storage. This is particularly true for ZIBs using aqueous electrolytes, but unfortunately, they suffer from severe degradation issues that have not been resolved despite of extensive research efforts in this field. Hybrid electrolytes using both water and dimethyl sulfoxide (DMSO) as a solvent are proposed, which combine the non-flammable properties of water-based electrolytes with the stability of solvent-based electrolytes. Further, this hybrid electrolyte allows for using tetrafluoroborate (Zn(BF 4 ) 2 ) as a salt, which readily corrodes Zn in aqueous formulations, but also contributes to a more stable SEI in the hybrid solvent system. These results are corroborated using Density Functional Theory (DFT) simulations to show how DMSO modifies the solvation structure, as well as HRTEM to analyze the SEI structure and composition. Finally, it is demonstrated that the hybrid electrolyte suppresses the dissolution of NVO cathodes, allowing Zn||NVO full cells to operate stably for over 2000 cycles with ≈80% capacity retention. Overall, this work illustrates how mixed solvent-water based electrolytes have the potential to retain the safety and cost advantages of aqueous electrolytes, while at the same time suppressing degradation mechanisms.}, archive = {J_ADVS}, author = {Wei Huang and Ze He and Boya Cao and Minfei Fei and Xinjuan Li and Shaoliang Guan and Qing Dai and Rui Wang and Shijie Zhu and Xunyao Luo and Tianhao Wu and Simon Fairclough and Caterina Ducati and Michael De Volder}, doi = {10.1002/advs.202507332}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07332}, shortjournal = {Adv. Sci.}, title = {Enhanced cycling stability in zn-ion batteries using aqueous-organic electrolyte solvent blends}, volume = {12}, year = {2025}, }
• (2025). Bioactive silk Sericin/Bioceramic nerve guidance conduit for effective repair of long-gap transected peripheral nerve injury through regulating schwann cells. ADVS, 12(38), e07241. (www)

  @article{ , abstract = {Schwann cells are pivotal in generating a pro-regenerative microenvironment for long-gap peripheral nerve injury (PNI) repair via their orchestrated behaviors, including cell migration, proliferation, and secretion. Bioceramics can release bioactive ions to regulate “repair” cells for regenerating damaged tissues. Herein, bioceramic akermanite (AT) is screened and found to significantly enhance Schwann cell proliferation, migration, and secretion by activating the PI3K/AKT and MAPK/ERK signaling pathways. Integration with silk sericin (SS), a natural biomaterial possessing excellent bioactivity, promotes the release of Ca and Mg from AT, synergistically enhancing Schwann cell pro-regenerative behaviors and accelerating axon elongation. The AT-SS composite conduit effectively restores nerve structure and function in a 13 mm transected PNI. Compared with commercial eton conduit, AT-SS conduit promotes axons and myelin sheaths regeneration, improves nerve conduction, and effectively alleviates gastrocnemius muscle atrophy. The AT-SS conduit achieves autograft-comparable behavioral recovery as evidenced by the paw withdrawal latency, hind limb grip force, and sciatic function index. The excellent degradation and biosafety of AT-SS conduit indicate its potential for clinical translation. This study introduces an ion-based therapeutic approach for enhancing the pro-regenerative functions of Schwann cells, and provides novel insights and strategies for clinically managing long-gap PNI and other nerve tissue injuries.}, archive = {J_ADVS}, author = {Qiangfei Su and Jian Wang and Yu Song and Zhaowenbin Zhang and Bo Cai and Xiakeerzhati Xiaohalati and Jingwei Liu and Haozhe Li and Zheng Wang and Jiang Chang and Lin Wang}, doi = {10.1002/advs.202507241}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07241}, shortjournal = {Adv. Sci.}, title = {Bioactive silk Sericin/Bioceramic nerve guidance conduit for effective repair of long-gap transected peripheral nerve injury through regulating schwann cells}, volume = {12}, year = {2025}, }
• (2025). PLAUR+ neutrophils drive anti-PD-1 therapy resistance in patients with hepatocellular carcinoma by shaping an immunosuppressive microenvironment. ADVS, 12(38), e07167. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) is characterized by an immunosuppressive tumor microenvironment (TME) that limits the efficacy of immune checkpoint inhibitors. However, the role of distinct neutrophil subsets within the TME in mediating tumor resistance to immunotherapy remains poorly understood. Here, the present study reveals that the urokinase-type plasminogen activator receptor (PLAUR) + neutrophils are enriched in immunotherapy non-responders and correlate with poor prognosis. Through multi-omics analyses of clinical cohorts and preclinical models, PLAUR + neutrophils identify as a pivotal driver of immunotherapy resistance by shaping an immunosuppressive TME. Mechanistically, spatial transcriptomics and single-cell RNA sequencing reveal that PLAUR + neutrophils orchestrate immune evasion by CD8 + T cell exclusion and macrophage-dependent immune suppression. Through the structure-based virtual screening, a novel PLAUR inhibitor is identified that could reverse the immunosuppressive phenotype of neutrophils. In various in vivo tumor models, PLAUR inhibitor suppresses tumor growth and potentiates the efficacy of anti-programmed cell death protein 1 (PD-1) therapy. These results demonstrate that PLAUR + neutrophils serve as a critical regulator of immunotherapy resistance and targeting PLAUR is a promising strategy to augment the efficacy of anti-PD-1 therapy in HCC.}, archive = {J_ADVS}, author = {Shaoqing Liu and Yanzhao Zhou and Gaoxiang Li and Bingwen Zhu and Fang Wu and Jinxue Zhou and Xiaobing Chen and Bo Qin and Yanxia Gao and Fazhan Wang and Yong Jiang and Wenxin Xu}, doi = {10.1002/advs.202507167}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07167}, shortjournal = {Adv. Sci.}, title = {PLAUR+ neutrophils drive anti-PD-1 therapy resistance in patients with hepatocellular carcinoma by shaping an immunosuppressive microenvironment}, volume = {12}, year = {2025}, }
• (2025). Dual-graded microstructure engineering for flexible piezoresistive sensors with high sensitivity and broad linear range in physiological monitoring. ADVS, 12(38), e07135. (www)

  @article{ , abstract = {Flexible piezoresistive sensors that offer both high sensitivity and a broad linear detection range are highly desirable for wearable health monitoring, as they facilitate simplified circuit design and enable accurate detection of subtle physiological signals. However, existing sensors typically encounter an intrinsic trade-off between sensitivity and linearity, primarily due to structural stiffening under increasing pressure. Here, a flexible piezoresistive pressure sensor featuring dual-graded microstructures (DGM) is reported, formed by embedding multi-walled carbon nanotubes (MWCNTs) into a thermoplastic polyurethane matrix. Leveraging the synergistic effects of progressive structural deformation and MWCNTs-induced tunneling conduction, the sensor achieves a high sensitivity of 69.8 kPa⁻¹ and a broad linear sensing range up to 300 kPa ( R 2 ≈ 0.998). The sensor also exhibits rapid response-relaxation time (totaling 5 ms), stable high-frequency detection up to 200 Hz, and good stability over 5 000 repeated loading cycles. Demonstrations in physiological monitoring confirm the sensor's capability to precisely capture detailed radial pulse waveforms, respiratory rhythms, and subtle heartbeat-induced vibrations. Both a scalable, cost-effective structural fabrication and good overall sensing performance establish the DGM-based sensor as a promising candidate for advanced wearable healthcare monitoring devices.}, archive = {J_ADVS}, author = {Ningning Bai and Dandan Xu and Zhuang Su and Gangqiang Li and Lilong He and Yanli Chen and Chengxi Guo and Linxuan Zhou and Xianming Qin and Ji Zhang and Daowei Wu and Weidong Wang}, doi = {10.1002/advs.202507135}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07135}, shortjournal = {Adv. Sci.}, title = {Dual-graded microstructure engineering for flexible piezoresistive sensors with high sensitivity and broad linear range in physiological monitoring}, volume = {12}, year = {2025}, }
• (2025). Cascade-targeted nanoparticles for enhanced gemcitabine delivery and adenosine metabolism modulation to overcome treatment resistance in pancreatic cancer. ADVS, 12(38), e07118. (www)

  @article{ , abstract = {KRAS mutations are find in over 90% of pancreatic ductal adenocarcinoma (PDAC) cases, making PDAC exhibit intrinsic resistance to chemotherapy and reshape the immunosuppressive tumor microenvironment (TME), disappointing the clinically preferred chemotherapy-immunotherapy combination. Standing on the cross point of therapeutic resistance, the aberrant adenosine metabolism contributes greatly to chemo- and immunotherapy tolerance. KRAS mutation-induced over-expression of key enzyme CD39 is believed to be involved in shaping the immunosuppressive TME, as it catalyzes the hydrolysis of extracellular ATP into immunosuppressive adenosine. Meanwhile, the loss of equilibrative nucleoside transporters (ENTs) leads to the accumulation of adenosine and the intracellular delivery difficulty of gemcitabine, further vanishing patients’ hope of benefiting from either chemotherapy or immunotherapy. The key challenge is to modulate the aberrant metabolism, also enhance gemcitabine intracellular delivery. Therefore, ROS-responsive positively-charged polymer B-PDEA is prepared and assembled into polyplexes for loading CD39-down-regulating small interfering RNA. Gemcitabine-loaded albumin is coupled with the polyplexes through enzyme-cleavable peptide, forming the intact nanoparticles for the co-delivery of the first-line chemotherapeutic drug and CD39-regulating nucleic acid, showing enhanced gemcitabine intracellular delivery and adenosine metabolism regulating capacity. This approach activated antitumor immunity while achieving chemosensitization by changing the metabolic-immune crosstalk of TME, showcasing great potential for PDAC treatment.}, archive = {J_ADVS}, author = {Hongrui Fan and Hongyi Chen and Haolin Song and Chufeng Li and Yu Wang and Zhenhao Zhao and Qin Guo and Xuwen Li and Mingxuan Liu and Tao Sun and Chen Jiang}, doi = {10.1002/advs.202507118}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07118}, shortjournal = {Adv. Sci.}, title = {Cascade-targeted nanoparticles for enhanced gemcitabine delivery and adenosine metabolism modulation to overcome treatment resistance in pancreatic cancer}, volume = {12}, year = {2025}, }
• (2025). Deterministic fabrication of plasmonic nanostructures on optical nanofibers via blurred electron beam deposition. ADVS, 12(38), e07004. (www)

  @article{ , abstract = {This study introduces a novel method for the deterministic fabrication of metallic nanostructures with controlled geometry and composition on suspended, single-mode tapered optical nanofibers (TNFs) using a tailored Blurred Electron Beam Induced Deposition (BEBID) technique. TNFs, owing to their subwavelength diameters and intense evanescent fields, offer a unique platform for enhanced light–matter interactions at the nanoscale. However, their mechanical fragility has thus far hindered the integration of plasmonic structures using conventional high-energy deposition methods. BEBID addresses this limitation by deliberately defocusing the electron beam to reduce local mechanical stress, minimize vibration, and prevent fiber damage during deposition, thereby enabling the one-step growth of platinum nanopillars with sub-20 nm spatial precision and high structural fidelity directly on suspended TNFs. The fabricated structures are characterized using SEM, EDX, and their optical properties are investigated through broadband scattering spectra and polarization-resolved measurements, showing strong agreement with Finite-Difference Time-Domain (FDTD) simulations. Numerical modeling further reveals that ordered arrays of nanopillars can shape and direct the scattered field along the fiber axis, enabling directional emission. This work establishes BEBID as a versatile nanofabrication approach for functional photonic architectures on fragile substrates, with direct applications in quantum photonics, nano-optics, and on-fiber plasmonic sensing.}, archive = {J_ADVS}, author = {Antonio Balena and Marianna D'Amato and Muhammad Fayyaz Kashif and Chengjie Ding and Lucien Belzane and Gaia De Marzo and Hanna Le Jeannic and Massimo De Vittorio and Ferruccio Pisanello and Alberto Bramati}, doi = {10.1002/advs.202507004}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e07004}, shortjournal = {Adv. Sci.}, title = {Deterministic fabrication of plasmonic nanostructures on optical nanofibers via blurred electron beam deposition}, volume = {12}, year = {2025}, }
• (2025). Domain-wall driven suppression of thermal conductivity in a ferroelectric polycrystal. ADVS, 12(38), e06931. (www)

  @article{ , abstract = {A common strategy for reducing the thermal conductivity of polycrystalline systems is to increase the number of grain boundaries. Indeed, grain boundaries enhance the probability of phonon scattering events, which has been applied to control the thermal transport in a wide range of materials, including hard metals, diamond, oxides, and two-dimensional (2D) systems such as graphene. Here, the opposite behavior in improper ferroelectric ErMnO 3 polycrystals is reported, where the thermal conductivity decreases with increasing grain size. This unusual relationship between heat transport and microstructure is attributed to phonon scattering at ferroelectric domain walls. The domain walls are more densely packed in larger grains, leading to an inversion of the classical grain-boundary-dominated transport behavior. The findings open additional avenues for microstructural engineering of materials for thermoelectric and thermal management applications, enabling simultaneous control over mechanical, electronic, and thermal properties.}, archive = {J_ADVS}, author = {Rachid Belrhiti-Nejjar and Manuel Zahn and Patrice Limelette and Max Haas and Lucile Féger and Isabelle Monot-Laffez and Nicolas Horny and Dennis Meier and Fabien Giovannelli and Jan Schultheiß and Guillaume F. Nataf}, doi = {10.1002/advs.202506931}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06931}, shortjournal = {Adv. Sci.}, title = {Domain-wall driven suppression of thermal conductivity in a ferroelectric polycrystal}, volume = {12}, year = {2025}, }
• (2025). Cancer neuroscience: Decoding neural circuitry in tumor evolution for targeted therapy. ADVS, 12(38), e06813. (www)

  @article{ , abstract = {Recent breakthroughs in tumor biology have redefined the tumor microenvironment as a dynamic ecosystem in which the nervous system has emerged as a pivotal regulator of oncogenesis. In addition to their classical developmental roles, neural‒tumor interactions orchestrate a sophisticated network that drives cancer initiation, stemness maintenance, metabolic reprogramming, and therapeutic evasion. This crosstalk operates through multimodal mechanisms, including paracrine signaling, electrophysiological interactions, and structural innervation guided by axon-derived guidance molecules. Key discoveries reveal that tumors actively recruit and remodel local neurons, hijacking neurodevelopmental pathways to foster invasive growth. Moreover, malignant cells exhibit neuronal-like plasticity, adopting electrophysiological properties that increase survival under therapeutic stress. These findings position neural mimicry as a hallmark of aggressive cancers. The expanding field of cancer neuroscience seeks to unravel the essential signaling factors that drive the complex communication between cancer and the nervous system, utilizing these findings to enhance precision therapies for cancer management. In this Review, we highlight considerable advancements in cancer neuroscience studies, sparking further discussions on various research possibilities and outlining a direction for future investigations. Additionally, we explored promising therapeutic strategies rooted in neural–tumor interactions that could synergize with conventional standard treatments, offering renewed therapeutic vigor for many refractory malignancies.}, archive = {J_ADVS}, author = {Mengyu Yuan and Rongjiao Xi and Yong Kang and Ming-jie Kuang and Xiaoyuan Ji}, doi = {10.1002/advs.202506813}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06813}, shortjournal = {Adv. Sci.}, title = {Cancer neuroscience: Decoding neural circuitry in tumor evolution for targeted therapy}, volume = {12}, year = {2025}, }
• (2025). Neuro-cancer interactions shape glioma intratumoral heterogeneity. ADVS, 12(38), e06694. (www)

  @article{ , abstract = {Glioma intratumoral heterogeneity remains a critical barrier to effective treatment, driving recurrence and resistance to therapy. Emerging evidence suggests that glioma cells acquire neural-like features through paracrine and synaptic communication with neural cells, fostering functional diversity within tumors. While neuro-cancer interactions are implicated in glioma heterogeneity, their precise roles remain incompletely synthesized. Here, by consolidating these discoveries, a conceptual framework is proposed for understanding the glioma intratumoral heterogeneity shaped by neuro-cancer interactions: cellular phenotypes, spanning neurogliomal synapses, glioma networks, and neuronal-like motility; and transcriptional states, which exhibit remarkable resemblance to neural cells. These diverse cellular phenotypes and transcriptional states synergistically fuel glioma progression, invasion, and resistance. By emphasizing the converging phenotypical and transcriptional evidence with spatial context within them, an underexplored but critical role of neuro-cancer interactions are proposed in glioma intratumoral heterogeneity. This provides potential strategies to explore and disrupt these neuro-cancer interactions, offering new insights to address glioma intratumoral heterogeneity for improved therapeutic outcomes.}, archive = {J_ADVS}, author = {Tong Wu and Peiran Zhao and Zheng Chen and Tianlei Ying and Zhihong Nie and Wei Hua and Huiyan Li and Ying Mao and Wenbo Bu}, doi = {10.1002/advs.202506694}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06694}, shortjournal = {Adv. Sci.}, title = {Neuro-cancer interactions shape glioma intratumoral heterogeneity}, volume = {12}, year = {2025}, }
• (2025). Exosomal CCT6A secreted by cancer-associated fibroblasts interacts with β-catenin to enhance chemoresistance and tumorigenesis in gastric cancer. ADVS, 12(38), e06674. (www)

  @article{ , abstract = {Cancer-associated fibroblasts (CAFs) are pivotal components of the tumor microenvironment that drive gastric cancer (GC) progression and chemoresistance. Here, CCT6A is identified as a CAF-derived factor whose high expression is positively associated with GC progression and plays a key regulatory role in stemness, chemoresistance, and glucose metabolism. In a co-culture system of CAFs and cancer cells, it is discovered that CCT6A is transferred from CAFs to tumor cells mainly via exosomal transport, thereby enhancing stemness, chemoresistance, and glycolysis. Mechanistically, CCT6A interacts with β-catenin, inducing its phosphorylation and nuclear translocation, which subsequently leads to transcriptional suppression of the glycolysis inhibitors DDIT4 and TXNIP through c-Myc activation. Furthermore, a feedforward regulatory loop is uncovered in which the CCT6A pseudogene CCT6P1 acts as a competitive endogenous RNA (ceRNA) by sequestering miR-922, thereby stabilizing CCT6A expression, while c-Myc co-activates both CCT6A and CCT6P1, amplifying oncogenic signaling. Collectively, the findings not only reveal the pivotal mediator of CAF-secreted CCT6A in orchestrating stemness, chemoresistance, and metabolic reprogramming in GC but also highlight its dual utility as a diagnostic biomarker and therapeutic target.}, archive = {J_ADVS}, author = {Hui Sun and Tianqi Zhang and Xiaoyan Zhang and Yingxue Liu and Xu Wang and Xin Wang and Cong Tan and Shujuan Ni and Weiwei Weng and Meng Zhang and Lei Wang and Dan Huang and Xiaoyu Wang and Wenfeng Wang and Weiqi Sheng and Mi-die Xu}, doi = {10.1002/advs.202506674}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06674}, shortjournal = {Adv. Sci.}, title = {Exosomal CCT6A secreted by cancer-associated fibroblasts interacts with β-catenin to enhance chemoresistance and tumorigenesis in gastric cancer}, volume = {12}, year = {2025}, }
• (2025). SuFEx-enabled catalytic synthesis of fluorescent organosulfur polymers for the rapid detection of explosives. ADVS, 12(38), e06616. (www)

  @article{ , abstract = {The rapid and straightforward detection of explosive molecules is crucial for ensuring public safety and national security. Herein, a new series of conjugated polymers, referred to as the SP series, incorporating pentiptycene structures with organosulfur (sulfide and sulfonate ester) side chains, which is developed via sulfur(VI)-fluoride exchange (SuFEx) click chemistry. These polymers enhance the detection capabilities of nitroaromatic explosives through improved fluorescence quenching mechanisms. The method involved synthesizing β-sulfido sulfonyl fluorides via superbase-catalyzed thia-Michael reactions, introducing sulfonates through SuFEx conjugation, and assembling the polymers via palladium-catalyzed Sonogashira coupling. The SP-7 polymer, in particular, shows exceptional performance in explosives detection (DNT and TNT), achieving a >99% quenching efficiency within a few seconds, far surpassing existing polymer sensors. The fluorescence quenching dynamics via electron transfer in the SP-7 polymer are thoroughly elucidated using time-resolved photoluminescence and transient absorption spectroscopy, revealing that both static and dynamic quenching processes are highly effective. Remarkably, a straightforward yet powerful TLC-spotting-based technique is demonstrated that enables the rapid (<30 s) and selective detection of explosives under UV irradiation. This finding underscores the potential of SP series polymers in explosive practical detection, promising significant improvements in public security technologies.}, archive = {J_ADVS}, author = {Sun Bu Lee and Jaeyoung Heo and Seunghyun Noh and Tae Eun An and Gyeongsoo Kim and Gang Min Lee and Junggong Kim and Keunyoung Kim and Jongman Lee and Taeyeon Kim and Changsik Song and Han Yong Bae}, doi = {10.1002/advs.202506616}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06616}, shortjournal = {Adv. Sci.}, title = {SuFEx-enabled catalytic synthesis of fluorescent organosulfur polymers for the rapid detection of explosives}, volume = {12}, year = {2025}, }
• (2025). Stirring without stirrers: Polymer fouling-driven mass transport unlocks order-of-magnitude gain in electrochemiluminescence. ADVS, 12(38), e06610. (www)

  @article{ , abstract = {Electrode reactions are central to analytical chemistry and a green approach to chemical synthesis. Here, it is demonstrated that sacrificing electrode-electrolyte contact to microscale polymeric blocks creates fouled electrodes that outperform unobstructed ones. By tuning the dielectric's geometry, surface chemistry, and charge – and controlling electrode alignment relative to gravity – a paradigm shift in electrode design, from “clean” to “fouled,” as a strategy to enhance reaction rates is proposed. Electrochemiluminescence (ECL) microscopy reveals that strategic electrode fouling enhances mass transport, primarily through electrochemically actuated lateral density gradients. Engineered fouling induces flow velocities up to 0.4 cm s −1 in otherwise quiescent systems. Sub-millimeter plastic features boost local rates by up to 290%, while micrometer-scale arrays yield a 30% net electrolysis gain. Through electrolyte engineering, it is shown that beyond expected hydrophobic reactant enrichment, the chemistry of the insulator influences reaction rates via electroosmotic flow and Marangoni-driven convection at the insulator-electrode-electrolyte boundary. This work establishes engineered fouling as a powerful strategy for enhancing electrochemical processes and provides a framework for designing advanced electrode architectures for ECL and electrosynthetic applications.}, archive = {J_ADVS}, author = {Wathsala Prasadini Kapuralage and Hemendra Kala and Mariusz Martyniuk and Nadim Darwish and Melanie MacGregor and K. Swaminathan Iyer and Simone Ciampi}, doi = {10.1002/advs.202506610}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06610}, shortjournal = {Adv. Sci.}, title = {Stirring without stirrers: Polymer fouling-driven mass transport unlocks order-of-magnitude gain in electrochemiluminescence}, volume = {12}, year = {2025}, }
• (2025). M6A reader hnRNPA2B1 modulates late pachytene progression in male meiosis through post-transcriptional control. ADVS, 12(38), e06600. (www)

  @article{ , abstract = {N 6 -methyladenosine (m 6 A) reader proteins have been demonstrated to be involved in numerous biological processes. However, the regulatory mechanism of specific m 6 A reader proteins during mammalian meiotic processes remains largely elusive. Here, this study identified hnRNPA2B1 as an m 6 A reader protein that plays a critical role in meiotic pachytene progression using a tamoxifen-induced knockout mouse model. Deletion of hnRNPA2B1 in spermatocytes disrupts homologous recombination and synapsis, with the mislocalization of double-strand break (DSB) repair proteins beyond the chromosome axes in pachytene spermatocytes. Multi-omics analyses revealed extensive dysregulation of the transcriptome and proteome in hnRNPA2B1-deficient spermatocytes, particularly affecting genes involved in chromosome organization, meiotic cell cycle, and DNA damage response, thereby triggering the pachytene checkpoint for cell elimination. In vitro luciferase assays confirmed that hnRNPA2B1 directly targets several meiosis-related transcripts (e.g., Ep400 , Rrs1 , etc.) in an m 6 A-dependent manner to regulate their expression. Furthermore, this finding demonstrates that hnRNPA2B1 biologically interacts with mRNA processing regulators and translation factors (e.g., eIF4G3, RPS3, RPL13, DDX5, YTHDC2) and functions as a post-transcriptional factor essential for pachytene progression during male meiosis. Collectively, this study underscores the critical role of the m 6 A reader hnRNPA2B1 in the pachytene checkpoint and advances our understanding of the regulatory mechanisms underlying male meiosis.}, archive = {J_ADVS}, author = {Lisha Yin and Yuting Zhang and Bingqian Zhang and Jin Zhang and Mengneng Xiong and Nan Jiang and Jinxin Xiao and Huihui Gao and Wenjing Xiong and Xiaoli Wang and Fengli Wang and Shuiqiao Yuan}, doi = {10.1002/advs.202506600}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06600}, shortjournal = {Adv. Sci.}, title = {M6A reader hnRNPA2B1 modulates late pachytene progression in male meiosis through post-transcriptional control}, volume = {12}, year = {2025}, }
• (2025). Akkermansia muciniphila-derived N-acetylspermidine modulates the localization of intestinal α1,2-fucosylated proteins to maintain gut homeostasis. ADVS, 12(38), e06576. (www)

  @article{ , abstract = {The growing incidence of inflammatory bowel diseases, including colitis and Crohn's disease, poses a critical challenge for global healthcare. Current development of α1,2-fucosylation-enhancing strategies shows significant potential as a colitis treatment modality by promoting gut homeostasis. Although certain probiotics alleviate colitis by enhancing intestinal α1,2-fucosylation, the molecular mechanisms by which probiotics-derived metabolites modulate this process remain unclear. This study found that the probiotic Akkermansia muciniphila ( A. muciniphila ) enhanced intestinal α1,2-fucosylation, a crucial factor contributing to its colitis-alleviating effects. Specifically, A. muciniphila -derived N-acetylspermidine upregulated α1,2-fucosylation, thereby enhancing barrier integrity and suppressing inflammation, which are reversed upon α1,2-fucosylation inhibition. Mechanistically, N-acetylspermidine upregulated HDAC2 via PIM1 inhibition, leading to decreased chromatin accessibility at the TP73 locus, subsequently increasing the expression of α1,2-fucosylation-associated gene C1GALT1C1 . Furthermore, N-acetylspermidine-induced α1,2-fucosylation enhancement facilitated the membrane localization of ZO-1 and ZO-2, while suppressing C3 secretion, both of which contributed to colitis alleviation. Together, our findings elucidate how A. muciniphila and its metabolite N-acetylspermidine regulate intestinal α1,2-fucosylation to maintain gut homeostasis and highlight their therapeutic potential in developing biological therapies for colitis.}, archive = {J_ADVS}, author = {Ye Yao and Zhangming Pei and Yuanyuan Dai and Yinghan Chen and Zepeng Chang and Hongchao Wang and Jianxin Zhao and Hao Zhang and Qixiao Zhai and Wenwei Lu and Wei Chen}, doi = {10.1002/advs.202506576}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06576}, shortjournal = {Adv. Sci.}, title = {Akkermansia muciniphila-derived N-acetylspermidine modulates the localization of intestinal α1,2-fucosylated proteins to maintain gut homeostasis}, volume = {12}, year = {2025}, }
• (2025). Boosting the charge output of enclosed liquid-based nanogenerators by electrowetting-assisted charge injection approach. ADVS, 12(38), e06517. (www)

  @article{ , abstract = {Liquid-based nanogenerators (L-NGs) have emerged as a promising solution for clean energy, appreciated for their minimal friction and effective contact at solid-liquid interfaces. Enclosed L-NGs, in particular, offer the benefits of enhanced durability and versatility. However, a key issue with enclosed L-NGs is the low charge density resulting from triboelectrification at the liquid-solid interface. In this study, this challenge is addressed by employing an electrowetting-assisted charge injection (EWCI) approach to significantly enhance the charge output of the enclosed nanogenerator, which this study refers to as the EW-NG. After EWCI treatment, the charge density has been enhanced by approximately ninefold, achieving a volumetric output charge density of 19.1 mC m −3 , surpassing previous reports. The EWCI also ensures stable charge retention, contributing to the device's exceptional robustness, as evidenced by no significant degradation during intermittent testing over six months. Moreover, the high flexibility of the water within the device allows for operation in various modes and the generation of power from diverse mechanical energy sources. The EW-NG has been successfully demonstrated to power an LCD screen with a size of 10 inches. This adaptability highlights the device's significant potential for applications in energy harvesting and self-powered electronic systems in the field of the Internet of Things.}, archive = {J_ADVS}, author = {Ye Zhao and Leiyang Wang and Guo Li and Chenlu Rao and Yuqi Pan and Borong Chen and Haihong Xu and Frieder Mugele and Hao Wu}, doi = {10.1002/advs.202506517}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06517}, shortjournal = {Adv. Sci.}, title = {Boosting the charge output of enclosed liquid-based nanogenerators by electrowetting-assisted charge injection approach}, volume = {12}, year = {2025}, }
• (2025). Contribution of prostaglandin e2-induced neuronal excitation to drug resistance in glioblastoma countered by a novel Blood–Brain barrier crossing celecoxib derivative. ADVS, 12(38), e06336. (www)

  @article{ , abstract = {Glioblastoma (GBM) is a highly aggressive brain tumor. Its poor prognosis is primarily due to recurrence and resistance to standard therapies, such as temozolomide (TMZ). Emerging evidence suggests that neuronal excitation within the tumor microenvironment contributes to the progression and chemoresistance of GBM. This study identifies prostaglandin E2 (PGE2) as a key regulator of neuronal activity that promotes tumor resistance. It is demonstrated that PGE2 activates neurons via the prostaglandin E1 (EP1) receptor, leading to intracellular calcium influx and phosphorylation of calcium/calmodulin dependent protein kinase II (CaMKII), which enhances synaptic plasticity. Neuronal excitation results in upregulation of synaptic proteins and neurotransmitter alterations, notably increasing glutamine and asparagine levels, which correlate with heightened chemoresistance. Co-culture experiments confirmed that PGE2-stimulated neurons induce resistance in adjacent GBM cells, highlighting a neuron-tumor interaction that facilitates recurrence. To overcome this resistance mechanism, compound 11 is developed, a novel blood-brain barrier (BBB)-permeable celecoxib derivative that effectively inhibits PGE2 signaling. Treatment with compound 11 significantly reduces GBM growth, impairs neuronal excitation, and improves survival outcomes in preclinical models. These findings underscore PGE2-induced neuronal excitation as a critical driver of drug resistance in GBM, and implicate compound 11 as a promising therapeutic agent to counteract PGE2-driven tumor recurrence.}, archive = {J_ADVS}, author = {Chih-Jie Shen and Hsien-Chung Chen and Chien-Liang Lin and Amandeep Thakur and Raphael Onuku and I-Chung Chen and Hao-Yi Li and Kwang-Yu Chang and Jian-Ying Chuang and Wen-Bin Yang and Hong-Yi Lin and Yi-Ru Shen and Jing-Ping Liou and Wen-Chang Chang and Tsung-I Hsu}, doi = {10.1002/advs.202506336}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06336}, shortjournal = {Adv. Sci.}, title = {Contribution of prostaglandin e2-induced neuronal excitation to drug resistance in glioblastoma countered by a novel Blood–Brain barrier crossing celecoxib derivative}, volume = {12}, year = {2025}, }
• (2025). DiPaRIS: Dynamic and interpretable protein-RNA interactions prediction with U-shaped network and novel structure encoding. ADVS, 12(38), e06314. (www)

  @article{ , abstract = {Protein-RNA interactions play a critical role in various biological processes and disease development. Proteins interact with RNAs through dynamic binding sites that exhibit specific structural patterns under various cellular conditions. While current computational methods take RNA structures in vivo into account, they fall short in capturing the structure contextual association of nucleotides, limiting predictive accuracy. Here, diPaRIS, a deep learning method, is proposed to predict dynamic protein-RNA interactions with improved accuracy and enhanced interpretability by integrating RNA structures in vivo. diPaRIS introduces a novel encoding scheme for SHAPE-seq to encode nucleotide correlations, providing a more comprehensive representation of RNA structures. Leveraging a U-shaped network architecture, diPaRIS not only improves prediction performance but also enables interpretable analysis by learning sequence binding motifs and generating attribution maps. Benchmarking diPaRIS across 44 datasets shows its superiority over existing methods. The model consistently achieves the highest accuracy, AUC, AUPR, and F1-score across all datasets. Additionally, diPaRIS excels in cross-cell line predictions, consistently outperforming the second-best method across all datasets. Predictions by diPaRIS reflect the conservation of protein-RNA binding and facilitate further functional interpretation of genetic variants in complex diseases. The findings highlight that diPaRIS effectively predicts protein-RNA interactions and interprets potential gene-disease associations.}, archive = {J_ADVS}, author = {Lishen Zhang and Chengqian Lu and Xiaoqing Peng and Fei Guo and Hongdong Li and Jianxin Wang}, doi = {10.1002/advs.202506314}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06314}, shortjournal = {Adv. Sci.}, title = {DiPaRIS: Dynamic and interpretable protein-RNA interactions prediction with U-shaped network and novel structure encoding}, volume = {12}, year = {2025}, }
• (2025). Engineering decavalent, sperm-binding laminin-IgG hybrid antibodies for potent non-hormonal contraception. ADVS, 12(38), e06272. (www)

  @article{ , abstract = {Nearly half of pregnancies globally are unintended, reflecting the current unmet need in safe, effective non-hormonal contraception. While anti-sperm IgM is responsible for infertility in many women, stability and bioprocessing challenges with IgM make them ill-suited for non-hormonal contraception. Similarly, IgG lacks sufficient sperm agglutination potencies. To overcome these shortcomings, a novel, multivalent mAb platform is developed, based on fusing the Laminin 511 heterotrimerization domains to Fabs and IgG1-Fc, allowing for tuning of Fab valency (from 2–12) with molecular specificity. ‘LamH10’, the most potent mAb among the panel of polyvalent antibodies against CD52g on human sperm, comprises 10 Fabs per molecule, and achieves nanomolar potencies at physiological temperatures and retains stability in the acidic environment of human cervicovaginal mucus. In sheep, LamH10 reduced progressively motile sperm in the vagina by >99% within 2 min at just 33 µg per sheep. LamH10 utilizes the same conventional bioprocessing as IgGs, and can be formulated into rapidly dissolving tablets for on-demand contraception, achieving 100% sperm agglutination within minutes of vaginal dosing. The laminin-IgG hybrid platform not only forms the basis of the most potent biologic for nonhormonal contraception to date, but also represents a promising platform for multivalent mAbs for other applications.}, archive = {J_ADVS}, author = {Alison Schaefer and Keiichiro Kushiro and Bhawana Shrestha and Yong Zhu and Alysha Panjwani and Lauren Dawson and Haley Flowers and Kathleen L. Vincent and Samuel K. Lai}, doi = {10.1002/advs.202506272}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06272}, shortjournal = {Adv. Sci.}, title = {Engineering decavalent, sperm-binding laminin-IgG hybrid antibodies for potent non-hormonal contraception}, volume = {12}, year = {2025}, }
• (2025). Endothelial-derived CCL7 promotes macrophage polarization and aggravates septic acute lung injury via CCR1-mediated STAT1 succinylation. ADVS, 12(38), e06209. (www)

  @article{ , abstract = {Acute lung injury (ALI) is a significant complication of sepsis, wherein the interaction between pulmonary vascular endothelial cells and immune cells plays a pivotal role in the pathogenesis. In this study, it is demonstrated that secretion of chemokine C-C motif ligand 7 (CCL7) by endothelial cells (ECs) induces metabolic reprogramming and M1 polarization of C-C motif chemokine receptor 1-positive (CCR1⁺) macrophages. It is noteworthy that mice with specific inhibition of endothelial-derived CCL7 exhibit reduced severity of septic ALI, underscoring the critical role of CCL7 in the progression of sepsis. Mechanistically, activation of the CCL7–CCR1 axis enhances STAT1 succinylation through upregulation of KAT2A expression, leading to increased STAT1 binding to the promoter of glycolytic genes in macrophages. This epigenetic regulation modulates metabolic reprogramming and M1 polarization of macrophages, thereby driving inflammatory cascades in septic ALI. Furthermore, in sepsis models, Ccr1-knockout (Ccr1 -KO ) mice demonstrate attenuated lung inflammation and decreased mortality, highlighting the therapeutic potential of targeting the CCL7–CCR1 axis for the treatment of septic ALI. Collectively, findings provide novel insights into the metabolic reprogramming of macrophages and identify the CCL7–CCR1 axis as a promising therapeutic target for septic ALI.}, archive = {J_ADVS}, author = {Xue Li and Yuqin Long and Yunxi Zhu and Jiahui Gu and Ping Zhou and Changhong Miao}, doi = {10.1002/advs.202506209}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06209}, shortjournal = {Adv. Sci.}, title = {Endothelial-derived CCL7 promotes macrophage polarization and aggravates septic acute lung injury via CCR1-mediated STAT1 succinylation}, volume = {12}, year = {2025}, }
• (2025). Single-droplet dual-target quantification of circRNA biomarkers for colorectal cancer screening. ADVS, 12(38), e06159. (www)

  @article{ , abstract = {Circular RNAs (circRNAs) play a crucial role in the oncogenesis, progression, and chemoresistance of tumors. Here, two plasma circRNA biomarkers, circCK1γ3 and circWDR37 is identified and validated. Simultaneous analysis of these biomarkers has the potential to significantly improve the sensitivity of colorectal cancer (CRC) screening. Leveraging the distinct base-cutting preferences of these two Cas proteins, it is successfully expressed and purified LwaCas13a and PsmCas13b, and developed a one-pot Cas13a/13b-RPA assay for the simultaneous detection of circCK1γ3 and circWDR37. To achieve precise detection of circCK1γ3 and circWDR37, the Casµchip, which integrates droplet generation and digital quantification functionalities is designed and fabricated. The Casµchip enables the simultaneous detection of circCK1γ3 and circWDR37 within 70 min. This method exhibits excellent repeatability and high specificity, with a detection limit of 100 copies/reaction. The correlation coefficients for circWDR37 and circCK1γ3 detected by Casµchip and qPCR are 0.9113 and 0.8933, respectively. Casµchip analysis is conducted on a cohort of 60 clinical samples, and the findings indicate that this methodology holds promise for the early detection of colorectal cancer. Casµchip represents the profound integration of CRISPR diagnostics and microfluidic technology, offering a novel paradigm characterized by rapid, precise, and user-friendly features for molecular diagnosis.}, archive = {J_ADVS}, author = {Jingsong Xu and Yu Liu and Junheng Zhang and Shuang Yang and Tianming Li and Haiqian Huang and Qian Liu and Hengliang Wang and Li Cao and Zhenghua An and Min Li and Hua Wang}, doi = {10.1002/advs.202506159}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e06159}, shortjournal = {Adv. Sci.}, title = {Single-droplet dual-target quantification of circRNA biomarkers for colorectal cancer screening}, volume = {12}, year = {2025}, }
• (2025). Unlocking the interaction mechanism of CNTs and C-S-H on enhancing elastic and viscoelastic properties of alite paste. ADVS, 12(38), e05876. (www)

  @article{ , abstract = {Carbon nanotubes (CNTs) have demonstrated potential in enhancing the elasticity and viscoelasticity of cementitious materials, yet the mechanisms underlying their influence on hydrates remain unclear. This study employs experimental techniques and molecular dynamics simulations to elucidate the impact of CNTs on alite hydration, spanning initial stages to the hardened state. Results show that CNTs exhibit a weak nucleation effect, which is thus not the primary factor contributing to the enhancement of mechanical properties. Instead, improvements stem from refining the calcium silicate hydrate (C-S-H) gel structure and optimizing the spatial distribution of calcium hydroxide (CH) throughout hydration. The CNT-mediated modulation of Ca 2+ distributions strengthens C-S-H cohesion, refines pore size, and promotes the formation of high-density C-S-H, thereby improving elastic properties. Additionally, the influence of CNTs on shear deformation and particle orientation among C-S-H particles is highlighted for viscoelastic properties. These insights redefine CNT contributions, emphasizing their role in long-term ionic and structural tuning, and provide a foundation for designing advanced nanofiber-cement composites with superior mechanical performance.}, archive = {J_ADVS}, author = {Xi Chen and Jiseul Park and Weiyi Ji and Yujie Huang and Jian-Xin Lu and Zhangli Hu and Chi Sun Poon}, doi = {10.1002/advs.202505876}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05876}, shortjournal = {Adv. Sci.}, title = {Unlocking the interaction mechanism of CNTs and C-S-H on enhancing elastic and viscoelastic properties of alite paste}, volume = {12}, year = {2025}, }
• (2025). Homeostasis of DNA hemi-methylation in arabidopsis through methylation maintenance, DNA replication, and nucleosome positioning mechanisms. ADVS, 12(38), e05808. (www)

  @article{ , abstract = {The DNA methylome in eukaryotes is an equilibrium contributed by maintenance methylation, de novo methylation, demethylation, and DNA replication processes. The asymmetric hemi-methylation status is thought of as a transient intermediate state en route to full-methylation. However, the recent studies in mammalian cells suggest that hemi-methylated CG dyads in certain regions can be stably maintained and may serve as epigenetic marks. Compared to mammals, plants have more diversified methylomes often including non-CG dyads. In this work, hairpin BS-seq is performed to acquire dyad-resolution methylomes from Arabidopsis wildtype and methylation-deficient mutant lines. Analyses of methylomes across multiple lines reveal how different DNA methyltransferases influence the equilibrium of hemi- and full-methylation in vivo. The results suggest that nucleosomes may protect hemi-methylated dyads from being further methylated, resulting in relatively higher hemi-methylation frequencies in nucleosome-occupied than -depleted regions. Adjacent hemi-methylated dyads tend to have a strong strand-specificity, indicating that DNA replication is a driving force for the homeostasis of hemi-methylation. Overall, comprehensive multi-line and dyad-resolved DNA methylation maps in Arabidopsis is presented to reveal that the homeostasis of DNA hemi-methylation in plants is achieved through diverse methylation regulatory and chromatin-related activities.}, archive = {J_ADVS}, author = {Hengye Chen and Chenhuan Xu}, doi = {10.1002/advs.202505808}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05808}, shortjournal = {Adv. Sci.}, title = {Homeostasis of DNA hemi-methylation in arabidopsis through methylation maintenance, DNA replication, and nucleosome positioning mechanisms}, volume = {12}, year = {2025}, }
• (2025). Microwave-assisted synthesis of Cu/Co-based nanoheterostructures for high-efficiency alcohol oxidation. ADVS, 12(38), e05581. (www)

  @article{ , abstract = {Hybrid water splitting, using methanol or ethanol oxidation reactions (MOR and EOR) at the counter electrode during electrochemical hydrogen generation, offers an efficient alternative to the sluggish oxygen evolution reaction (OER). This study reports Cu/Co-based core-shell nanocrystals (NCs) showing excellent performance for both MOR and EOR. The structure, composition and size of the NCs can be controlled by adjusting the synthesis parameters in a one-pot microwave-assisted process. The electrocatalytic performance of the NCs shows lower potentials for both MOR and EOR compared to the OER. They consist of a copper-rich metallic core initially encapsulated by a shell composed of cobalt oxide and cobalt carbide. This nanoheterostructure evolves to a copper oxide core surrounded by an oxide shell consisting of small cobalt- and copper-oxide nanodomains upon chronopotentiometry experiments. The excellent performance in both MOR and EOR is attributed to the oxidation of the NCs and a concomitant diffusion process that forms small oxide clusters. The final structure provided NCs with high mass activities for both alcohol oxidation reactions, producing formic and acetic acid as products (for MOR and EOR, respectively). Finally, the NCs are tested for hybrid water electrolysis, demonstrating high hydrogen production along with high stability.}, archive = {J_ADVS}, author = {Xuesong Zhang and Jaume Gázquez and Arturo Pajares and Dino Tonti and Pablo Guardia}, doi = {10.1002/advs.202505581}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05581}, shortjournal = {Adv. Sci.}, title = {Microwave-assisted synthesis of Cu/Co-based nanoheterostructures for high-efficiency alcohol oxidation}, volume = {12}, year = {2025}, }
• (2025). The critical role of enhanced OXPHOS and mitochondrial hyperpolarization in simulated microgravity-induced oocyte maturation arrest. ADVS, 12(38), e05570. (www)

  @article{ , abstract = {Meiosis is essential for sexual reproduction, yet the impact of microgravity on oocyte maturation remains unclear, raising concerns for reproductive success in space environments. Here, it is examined the effects of simulated microgravity (SMG) on mouse oocytes and found that SMG impaired mitochondrial function, evidenced by elevated oxidative phosphorylation and mitochondrial membrane hyperpolarization, resulting in meiotic arrest. This response is distinct from that induced by other stressors or seen in somatic cells under microgravity, highlighting the unique sensitivity of oocytes. SMG also caused mitochondrial mislocalization, which activated the unfolded protein response and suppressed mitochondrial gene expression. Despite accelerating meiotic progression, SMG delayed microtubule-organizing center (MTOC) coalescence. This misalignment led to spindle defects, reduced polar body extrusion, and increased aneuploidy, compromising oocyte quality. The spindle assembly checkpoint (SAC) remained functional, suggesting mitochondrial dysregulation-not SAC failure-drives meiotic acceleration. Notably, even oocytes that reached maturation under SMG exhibited polarity loss and reduced developmental potential. Extending metaphase I by inhibiting the anaphase-promoting complex rescued MTOC assembly and spindle formation, significantly improving maturation rates. These findings identify mitochondrial dysfunction as a key mediator of SMG-induced meiotic failure and propose M-phase regulation as a strategy to safeguard female fertility in space environments.}, archive = {J_ADVS}, author = {Lei Ge and Yuqing Gao and Feifei Du and Chiyuan Ma and Tianxia Xiao and Yali Yang and Xiaohua Lei and Jian V. Zhang}, doi = {10.1002/advs.202505570}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05570}, shortjournal = {Adv. Sci.}, title = {The critical role of enhanced OXPHOS and mitochondrial hyperpolarization in simulated microgravity-induced oocyte maturation arrest}, volume = {12}, year = {2025}, }
• (2025). Extending the range of sizes of monodisperse core-shell hydrogel capsules from composite jet breakup by combined electrical and mechanical actuation. ADVS, 12(38), e05501. (www)

  @article{ , abstract = {The production of monodisperse particles or droplets is a longstanding issue across various fields, from aerosol science to inkjet printing. In bioengineering, sub-millimeter cell-laden hydrogel capsules have proven valuable for developing in vitro tissue models. A common practical approach for producing such droplets relies on the Plateau–Rayleigh instability to break up a liquid compound jet in air. However, while the droplet size is closely linked to nozzle dimensions, achieving high monodispersity suitable for quantitative biological assays remains challenging due to coalescence events associated with the beads-on-a-string morphology of viscoelastic jets. Here, a microfluidic strategy is introduced, combining electrical and mechanical actuation to enhance control and versatility over jet breakup. By fine-tuning the excitation frequency to select specific modes and applying an electric potential to regulate coalescence, a phase diagram is established, enabling the generation of monodisperse droplets over a broad size range. Notably, a previously hidden effect of the electric field on jet behavior is uncovered and quantitatively characterized. Finally, after crosslinking the compound droplets, capsules with a hydrogel envelope and a core composed of a cell suspension are formed in conditions compatible with cell proliferation, which lay the groundwork for quantitative high precision biological assays.}, archive = {J_ADVS}, author = {Lucas Suire and Anirban Jana and Pierre Nassoy and Amaury Badon}, doi = {10.1002/advs.202505501}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05501}, shortjournal = {Adv. Sci.}, title = {Extending the range of sizes of monodisperse core-shell hydrogel capsules from composite jet breakup by combined electrical and mechanical actuation}, volume = {12}, year = {2025}, }
• (2025). Translation of a human-based malaria-on-a-chip phenotypic disease model for in vivo applications. ADVS, 12(38), e05206. (www)

  @article{ , abstract = {In 2023 malaria claimed ≈600000 lives, with 90% of those deaths attributed to the Plasmodium falciparum parasite. This resurgence in mortality emphasizes the necessity of adopting alternative models to accelerate therapeutic development. The Malaria-on-a-Chip model used here incorporated human liver, spleen, and endothelium with P. falciparum- infected blood, and was maintained for 7 days using serum-free medium. This model sustained all stages of the intraerythrocytic life cycle and allowed for organ–organ interaction, providing advantageous preclinical insight into malaria pathophysiology. Chloroquine, lumefantrine, or artesunate were delivered as monotherapies to 3D7 or W2-infected systems. Dose-dependent parasite clearance was observed in both strains for all compounds. Recrudescence occurred in the 3D7-infected model following treatment with chloroquine or lumefantrine, but not artesunate. In W2-infected systems, chloroquine and lumefantrine treatment resulted in parasitemia stabilization by day 7, while artesunate further reduced parasitemia. Population dynamics modeling of pharmacokinetic and pharmacodynamic (PK/PD) outcomes were utilized to predict human in vivo parameters for efficacy and off-target toxicity using in vitro results.}, archive = {J_ADVS}, author = {Michael J. Rupar and Hannah M. Hanson and Brianna L. Botlick and Narasimhan Sriram and Stephanie Rogers and Justin Zuniga and Zhanhe Liu and Steven J. Trimmer and Joseph M. Ciurca and Christopher J. Long and Christopher W. McAleer and Stephan Schmidt and Paola Favuzza and Philip Lowe and Nathalie Gobeau and James J. Hickman}, doi = {10.1002/advs.202505206}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05206}, shortjournal = {Adv. Sci.}, title = {Translation of a human-based malaria-on-a-chip phenotypic disease model for in vivo applications}, volume = {12}, year = {2025}, }
• (2025). GmSop20 functions as a key coordinator of the oil-to-protein ratio in soybean seeds. ADVS, 12(38), e05181. (www)

  @article{ , abstract = {The seed oil-to-protein ratio has increased remarkably during soybean domestication; however, the principal genetic determinants governing this critical agronomic trait remain elusive. Integrated genome-wide and transcriptome-wide association studies (GWAS/TWAS) are conducted and identified GmSop20 on chromosome 20 as a pivotal regulator of soybean seed oil and its protein content. Genetic diversity analysis reveals a domestication-selected allele, GmSop20 C , which has undergone intense artificial selection and is dominant in cultivars across northern China and the USA. This allele drives a substantial increase in the oil-to-protein ratio from 0.35 in ancestral lines to 0.47 in cultivars. Functional validation reveals that the knockout of GmSop20 significantly reduces the ratio to 0.19, while its overexpression increases it to 0.64. Notably, while mutant lines exhibit a modest increase in total oil and protein content, overexpression maintains stable compositional levels. Mechanistically, GmSop20 directly activates GmSWEET10a expression, synergizing two artificially selected loci within a unified regulatory network to amplify sugar allocation from the seed coat to the embryo, thereby enhancing oil accumulation. The findings establish GmSop20 as a master regulator of seed composition and provide insights for custom-designing soybean nutritional profiles, enabling the precise regulation of the oil-to-protein ratio through targeted manipulation of this key genetic module.}, archive = {J_ADVS}, author = {Haowei Zheng and Xinkang Feng and Longlong Wang and Wentao Shao and Shiyu Guo and Duo Zhao and Jiajia Li and Long Yan and Long Miao and Bincheng Sun and Huihui Gao and Hongmei Qiu and Yu Hu and Linlin Kong and Robert M. Stupar and Ying-hui Li and Li-juan Qiu and Xiaobo Wang}, doi = {10.1002/advs.202505181}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05181}, shortjournal = {Adv. Sci.}, title = {GmSop20 functions as a key coordinator of the oil-to-protein ratio in soybean seeds}, volume = {12}, year = {2025}, }
• (2025). Therapeutic repair of sperm quality decline caused by polytetrafluoroethylene. ADVS, 12(38), e05148. (www)

  @article{ , abstract = {The alarming prevalence of environmental microplastics has raised global concerns about fertility. However, the detriment of polytetrafluoroethylene (PTFE, Teflon), a widely used microplastic in non-stick cookware, to sperm quality remains unclear. Here, a high detection rate (46.62%) and bioaccumulation of PTFE in the male urogenital system are reported and the mechanisms of PTFE exposure on male fertility are investigated in both humans and mice and potential therapeutic strategies are explored. These findings reveal that PTFE exposure delays the development of spermatogonia and spermatocytes, disrupts chromosomal synapsis and the DNA damage response, and promotes the apoptosis of spermatocytes. Interestingly, PTFE exposure specifically targets SKAP2 in the haploid spermatid, leading to disruption of the sperm cytoskeleton, abnormal sperm morphology, and decreased sperm motility. Strikingly, therapy targeting SKAP2 remodels sperm cytoskeleton and morphology and restores sperm motility and male fertility in humans and mice. Collectively, these works illustrate the mechanisms of PTFE exposure impairing spermatogenesis and highlight SKAP2 targeting as a promising therapeutic strategy for treating asthenoteratozoospermia in humans.}, archive = {J_ADVS}, author = {Shiming Gan and Shumin Zhou and Jiaming Zhou and Guanghui Zhang and Jingshou Chen and Rui Liu and Kuan Sun and Sisi Li and Wenjing Xiong and Yujiao Wen and Jianzhong Sheng and Yu Zhang and Jingchao Ren and Youjiang Li and Hefeng Huang and Chen Zhang}, doi = {10.1002/advs.202505148}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05148}, shortjournal = {Adv. Sci.}, title = {Therapeutic repair of sperm quality decline caused by polytetrafluoroethylene}, volume = {12}, year = {2025}, }
• (2025). Molecular creep induced fatigue rupture of fibrin clots. ADVS, 12(38), e05109. (www)

  @article{ , abstract = {Fibrin networks, the structural framework of thrombi, undergo fatigue failure under pulsatile blood flow, posing risks of embolic events like stroke, pulmonary embolism. While fibrin's fracture behavior under monotonic loading has been intensively explored, its fatigue mechanism that governs thrombus embolization is understudied. Multiscale experiments, modeling of condensed fibrin networks, reveal a paradoxically low fatigue threshold despite high fracture energy. Mechanistically, cyclic loading induces irreversible α-to-β transitions in fibrin's molecular chains, causing molecular creep that dissipates strain energy, propagates cracks via rupture of stress-localized fibers. A multiscale continuum model quantitatively links this nanoscale mechanics to macroscale fatigue, providing an alternative mechanism of thrombus rupture as a molecular disorder driven by cumulative conformational damage. These findings reexamine widely adopted fibrous hydrogel design paradigms while bridging molecular structure characteristics to clinical thrombosis–a critical step toward predictive rupture risk assessment, targeted therapeutic strategies.}, archive = {J_ADVS}, author = {Dani Liu and Zichang Jia and Binchao Liu and Jizhe Hou and Rui Bao and Mingkun Wang}, doi = {10.1002/advs.202505109}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e05109}, shortjournal = {Adv. Sci.}, title = {Molecular creep induced fatigue rupture of fibrin clots}, volume = {12}, year = {2025}, }
• (2025). Ternary molecular co-assembling heterogeneous membranes for high-efficiency and anti-biofouling osmotic energy conversion. ADVS, 12(38), e04843. (www)

  @article{ , abstract = {Low-cost access to abundant, green osmotic energy through nanofluidic membranes holds promise to solve the economic, energy, and environmental trilemma. Despite considerable promising explorations, developing a nanofluidic membrane with ease of fabrication, high performance, and superior biofouling resistance remains a challenge. Here, a unique ternary molecular co-assembly strategy is presented to provide a solution. L-glutathione, Ag + ions, and histamine can co-assemble into twisted nanofibers through coordination and cross-linking. The co-assembly within anodic aluminum oxide (AAO) nanochannels, reinforced by polyvinyl alcohol (PVA), creates a heterogeneous membrane (AAO@GHAg/PVA) characterized by enhanced stability and mechanical strength. The AAO@GHAg/PVA membrane features asymmetric nanochannels that facilitate anion-selective unidirectional transport, achieving a peak output power density of 17.5 W·m −2 under a 50-fold salinity gradient. The inclusion of Ag endows AAO@GHAg/PVA with superior biofouling resistance, allowing it to maintain a maximum power density of 16.6 W·m −2 in a real seawater/river water environment. Interestingly, replacing histamine with spermine further boosts performance to 21.4 W·m −2 , demonstrating the extensibility of the molecular precursors. This work opens up a new avenue for the facile construction of high-efficiency nanofluidic membranes for osmotic energy harvesting.}, archive = {J_ADVS}, author = {Minmin Li and Yuting Xiong and Fenglin Zhang and Haijie Wei and Yuchen Cao and Guangyan Qing}, doi = {10.1002/advs.202504843}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04843}, shortjournal = {Adv. Sci.}, title = {Ternary molecular co-assembling heterogeneous membranes for high-efficiency and anti-biofouling osmotic energy conversion}, volume = {12}, year = {2025}, }
• (2025). Large-scale production of transfusion-ready red blood cells from induced pluripotent stem cells. ADVS, 12(38), e04725. (www)

  @article{ , abstract = {There is a constant worldwide need for blood products, traditionally obtained from donations. In vitro red blood cell (RBC) production could supplement this demand and offer benefits such as thorough screening for improved safety, the possibility of genetic manipulation to restore genetic deficiencies, and therapeutic loading. Induced pluripotent stem cells (iPSCs) are a promising cell source for transfusable RBCs due to their immortality and independence from donors. However, current iPSC differentiation protocols—including both monolayer and embryoid body-based systems—have failed to produce sufficient erythroid cells (10 11–12 per unit) for therapeutic application, primarily due to developmental immaturity, inefficient enucleation (5–25%), and suboptimal, static culture conditions lacking physiological relevance. This study describes the optimization of an iPSC to RBC differentiation platform and its step-by-step translation process to dynamic culture conditions, allowing scalability and eventual bioreactor application. The optimized dynamic culture yields ≈4.6 × 10 3 RBC/iPSC, requiring an estimated ≈4.9 × 10 7 iPSCs to produce a minitransfusion unit, achieving a consistent 40–70% enucleation rate and bona fide function, demonstrated by both in vitro and in vivo assays. Our feeder-free, GMP-compatible system accomplishes an enucleated RBC production rate sufficient for large-scale application and serves as a bridge to large-scale bioreactor RBC production, facilitating clinical application.}, archive = {J_ADVS}, author = {Eszter Varga and Eelke Brandsma and Brenda E. Juarez-Garza and Renuka P. E. Ramlal and Julien J. Karrich and Adrien Laurent and Athina Chavli and Ruthmila Paskel and Kerly Fu and Richard A. Flavell and Marieke von Lindern and Derk Amsen and Marieke E. Klijn and Emile van den Akker}, doi = {10.1002/advs.202504725}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04725}, shortjournal = {Adv. Sci.}, title = {Large-scale production of transfusion-ready red blood cells from induced pluripotent stem cells}, volume = {12}, year = {2025}, }
• (2025). A longitudinal study reveals metabolomic markers for individuals at risk, disease severity, and treatment response in rheumatoid arthritis. ADVS, 12(38), e04414. (www)

  @article{ , abstract = {Rheumatoid arthritis (RA) is a systemic inflammatory joint disease characterized by heterogeneous clinical manifestations, which requires deeper exploration in identifying reliable biomarkers for early diagnosis, monitoring, and treatment assessment. The aim is to discover plasma metabolomic markers to predict RA onset, assess disease activity, and forecast treatment efficacy. The study includes 209 established RA patients who are disease-modifying antirheumatic drugs-free for six months prior to enrollment, with 197 of them followed for 3–6 months to assess treatment response. Additionally, 56 individuals at risk are recruited, with 34 completing a 5–7-year follow-up. Analysis reveals that metabolites related to methylation and redox imbalance, such as S-adenosylmethionine, sarcosine, nicotinamide adenine dinucleotide, glutathione, etc., are associated with RA development and severity, and contribute to its heterogeneity across age, sex, and anti-citrullinated protein autoantibody status. Ridge regression models are constructed using metabolite and clinical features for the response to methotrexate (MTX) plus leflunomide, achieving an average receiver operating characteristic (ROC) score of 0.83, and for the MTX plus hydroxychloroquine, achieving an average ROC score of 0.92. In conclusion, our findings reveal RA metabolomic alterations, aiding early diagnosis and treatment response.}, archive = {J_ADVS}, author = {Chenxi Zhu and Jiayi Xu and Siyu He and Qian Niu and Yi Liu and Xin Guo and Huifang Hu and Rui Sun and Tao Chen and Yan Liu and Zhiqiang Xu and Na Jiang and Lipu Yao and Lunzhi Dai and Qinghua Zou and Fanxin Zeng and Liesu Meng and Inger Gjertsson and Rikard Holmdahl and Bin Yang and Dan Du and Yi Zhao}, doi = {10.1002/advs.202504414}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04414}, shortjournal = {Adv. Sci.}, title = {A longitudinal study reveals metabolomic markers for individuals at risk, disease severity, and treatment response in rheumatoid arthritis}, volume = {12}, year = {2025}, }
• (2025). RESP2: An uncertainty aware multi-target multi-property optimization AI pipeline for antibody discovery. ADVS, 12(38), e04350. (www)

  @article{ , abstract = {Discovery of therapeutic antibodies against infectious disease pathogens presents distinct challenges. Ideal candidates must possess not only the properties required for any therapeutic antibody (e.g., specificity, low immunogenicity) but also high affinity to many mutants of the target antigen. Here, we present RESP2, an enhanced version of the Rapid Engineering System for Proteins (RESP) pipeline, designed for the discovery of antibodies against one or multiple antigens with simultaneously optimized developability properties. First, we evaluated this pipeline in silico using the Absolut! database of antibodies docked to a variety of target antigens. RESP2 consistently identifies sequences that bind more tightly to groups of target antigens than any sequence present in the training set, with success rates ≥ 85%. As a comparison, popular generative artificial intelligence (AI) techniques achieve success rates <= 1.5%. Next, we used the receptor binding domain (RBD) of the COVID-19 spike protein as a case study, and discovered a highly human antibody with mid to high-affinity binding to at least eight different variants of the RBD. These results illustrate the advantages of RESP2 pipeline for antibody discovery against evolving targets. A Python package that enables users to utilize the RESP pipeline on their own targets is available at https://github.com/Wang-lab-UCSD/RESP2 .}, archive = {J_ADVS}, author = {Jonathan Parkinson and Ryan Hard and Young Su Ko and Wei Wang}, doi = {10.1002/advs.202504350}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04350}, shortjournal = {Adv. Sci.}, title = {RESP2: An uncertainty aware multi-target multi-property optimization AI pipeline for antibody discovery}, volume = {12}, year = {2025}, }
• (2025). Electromagnetically coupled resonant face-to-face double-layer metamaterial for highly sensitive THz impedance spectroscopy. ADVS, 12(38), e04331. (www)

  @article{ , abstract = {A new electromagnetic coupling mechanism is introduced between two passive terahertz (THz) electric-LC resonator metasurfaces, aimed at maximising THz metamaterial impedance spectroscopy sensitivity, translated into resonance spectral red-shift (Δ F ). When two resonant metasurfaces are brought into a face-to-face proximity and exposed to THz radiation, a resonant optical cavity is generated, and an electromagnetic coupling of THz radiation occurs from both metasurfaces. This coupling triggers the enhancement of plasmonic interaction between the incident THz radiation and the metasurfaces. It is found out that an optimal distance between the metasurfaces is a critical parameter for achieving an enhanced coupling of the electrical fields. Once optimally coupled, the double-layer metamaterial becomes an integrated sensor for THz impedance spectroscopy, exhibiting an enhanced resonance with a high Q-factor of 549, without any major requirements for alignment of the two metasurfaces. The double-layer metamaterial sensor achieves a high dielectric sensitivity of 2300 GHz RIU −1 that can detect a variety of inorganic and organic nanoparticles, as well as sugar in ultra-low concentrations. As an example, precise blood sugar tracking is demonstrated defining clear distinctions between hypoglycaemia, normal, borderline high, and hyperglycaemia, all based on Δ F . This novel sensor architecture has potential applications in high-sensitivity biosensing and ultra-low-concentration dielectric detection.}, archive = {J_ADVS}, author = {Rudrarup Sengupta and Heena Khand and Gabby Sarusi}, doi = {10.1002/advs.202504331}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04331}, shortjournal = {Adv. Sci.}, title = {Electromagnetically coupled resonant face-to-face double-layer metamaterial for highly sensitive THz impedance spectroscopy}, volume = {12}, year = {2025}, }
• (2025). Targeting Neutrophil/Eosinophil extracellular traps by aptamer-functionalized nanosheets to overcome recalcitrant inflammatory disorders. ADVS, 12(38), e04210. (www)

  @article{ , abstract = {Excessive generation of neutrophil extracellular traps (NETs) and eosinophil extracellular traps (EETs) can drive various inflammatory disorders by stimulating intracellular nucleic acid receptors. Although extracellular traps (ETs) are promising therapeutic targets for recalcitrant chronic inflammation, for example, otitis media with effusion (OME), practical and specific targeting of NETs/EETs in pathological tissues remains challenging. In this study, an ultrathin, 2D sheet-like nanoscavenger C-TA H is developed by modifying copper indium thiophosphate (CIPS) nanosheets with tannic acid (TA) and histone aptamers. The findings reveal that C-TA H effectively binds the dsDNA of NETs/EETs, inhibits bacterial growth, and reduces reactive oxygen species (ROS) levels, leading to a depressed local inflammation in ovalbumin (OVA)-induced OME rats. In addition, the therapeutic results also include reductions in inflammatory cytokines release, suppression of ETs-activated danger signaling pathways, including toll-like receptor 9 (TLR9) and nuclear factor-kappa B (NF-κB), as well as decreased mucous exudation and improved hearing functions. Comprehensively, transcriptomic analysis with RNA-sequencing confirms that C-TA H treatment significantly reverses the pathological gene expression changes after OVA sensitization. This work introduces an aptamer modification strategy for the target and capture of NETs/EETs, providing a potential therapeutic approach for modulating inflammatory signaling in OME as well as other recalcitrant inflammatory disorders.}, archive = {J_ADVS}, author = {Yongqiang Xiao and Xinyue Wang and Ming Liu and Xiao Fu and Nanfeng Zhang and Wenqing Yang and Junyi Ge and Yangyang Li and Duan Ma and Jing Ma and Weiping Wen and Dongdong Ren and Tianyu Zhang and Zhaoxu Tu}, doi = {10.1002/advs.202504210}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04210}, shortjournal = {Adv. Sci.}, title = {Targeting Neutrophil/Eosinophil extracellular traps by aptamer-functionalized nanosheets to overcome recalcitrant inflammatory disorders}, volume = {12}, year = {2025}, }
• (2025). Bacterial foreignization nanosystem elicits multi-phenotypic t cells for antitumor immunity. ADVS, 12(38), e04155. (www)

  @article{ , abstract = {T lymphocytes are pivotal targets in clinical cancer immunotherapy; however, tumor cells frequently evade the T-cell attacks by altering the intrinsic immunogenicity manifested as adjuvanticity, antigenicity, and reactogenicity. Here, a bacterial outer membrane vesicle (OMVs)-based nanosystem is presented to elicit robust T-cell responses by reshaping tumor immunogenicity. OMVs are engineered with vesicular stomatitis virus G-protein that facilitates the fusion of OMVs with tumor cells, leading to tumor “foreignization” and adjuvanticity augment. Consequently, the innate immune system is mobilized to sense the foreignized tumor cells and present the whole-cell tumor antigens, significantly improving the tumor antigenicity and priming multi-phenotypic T cells, including both pathogen-specific and tumor-specific T cells. Meanwhile, the tumor reactogenicity is reinvigorated through direct cytoplasmic delivery of siPD-L1 during the fusion, amplifying T cells-mediated cytotoxicity. In murine models, this foreignization strategy potentiates adaptive immunity and induces durable immune memory, thus effectively suppressing bilateral and metastatic tumors, demonstrating its therapeutic potential in comprehensively reprogramming tumor immunogenicity to fight cancer.}, archive = {J_ADVS}, author = {Wan-Ru Zhuang and Wen-Chi Xue and Chao Liang and Pan Liu and Yao Lei and Jiaqi He and Ran Cheng and Weidong Nie and Jianxiong Wang and Jie Tang and Hai-Yan Xie}, doi = {10.1002/advs.202504155}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04155}, shortjournal = {Adv. Sci.}, title = {Bacterial foreignization nanosystem elicits multi-phenotypic t cells for antitumor immunity}, volume = {12}, year = {2025}, }
• (2025). DeepSecMS advances DIA-based selenoproteome profiling through cys-to-sec proxy training. ADVS, 12(38), e04109. (www)

  @article{ , abstract = {Selenoproteins, defined as proteins containing the 21st amino acid, selenocysteine (Sec, U), are functionally important but rare, with only 25 selenoproteins characterized in the entire human proteome to date. To comprehensively analyze selenoproteomes, previously developed selenocysteine-specific mass spectrometry (SecMS) and the selenocysteine insertion sequence (SECIS)-independent selenoprotein database (SIS) have provided effective tools for analyzing the selenoproteome and, more importantly, hold the potential to uncover new selenoproteins. In this study, a deep learning approach is employed to develop the DeepSecMS method. Given the rarity of Sec and its chemical similarity to cysteine (Cys, C), a proxy training strategy is utilized using a large dataset of Cys-containing peptides to generate a large-scale theoretical library of Sec-containing peptides. It is shown that DeepSecMS enables the accurate prediction of critical features of Sec-containing peptides, including MS2, retention time (RT), and ion mobility (IM). By integrating DeepSecMS with data-independent acquisition (DIA) methods, the identification of known selenoproteins is significantly enhanced across diverse cell types and tissues. More importantly, it facilitates the identification of numerous highly scored, potential novel selenoproteins. These findings highlight the powerful potential of DeepSecMS in advancing selenoprotein research. Moreover, the proxy training strategy may be extended to the analysis of other rare post-translational modifications.}, archive = {J_ADVS}, author = {Chenfang Si and Yamei Yuan and Yu Zong and Liang Qiao and Wen-Feng Zeng and Yaoyang Zhang}, doi = {10.1002/advs.202504109}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04109}, shortjournal = {Adv. Sci.}, title = {DeepSecMS advances DIA-based selenoproteome profiling through cys-to-sec proxy training}, volume = {12}, year = {2025}, }
• (2025). Sleep deprivation activates a conserved lactate-H3K18la-RORα axis driving neutrophilic inflammation across species. ADVS, 12(38), e04028. (www)

  @article{ , abstract = {Sleep deprivation critically disrupts physiological homeostasis, impairing development, metabolic balance, and immune regulation, with excessive neutrophil activation being a hallmark consequence. However, the molecular mechanisms underlying sleep deprivation-induced neutrophilic inflammation remain elusive. Here, it is shown that acute sleep deprivation in mice triggers neutrophil hyperactivation, resulting in aberrant peripheral accumulation and a systemic cytokine storm. Mechanistically, this pathology is driven by metabolic dysregulation, specifically, increased glycolytic flux, which elevates tissue lactate levels and enhances histone H3K18 lactylation. Through H3K18 lactylation-specific CUT&Tag profiling, pronounced lactylation enrichment is identified at the promoter of the Rorα gene, directly activating its transcription. Genetic ablation of Rorα or pharmacological inhibition of glycolysis attenuate neutrophil recruitment and mitigated inflammation in sleep-deprived zebrafish. Strikingly, this metabolic‒epigenetic axis is evolutionarily conserved, as demonstrated by the recapitulation of key findings in diurnal zebrafish and pigs. The study reveals a lactate-H3K18 lactylation-Rorα signaling cascade that links sleep deprivation to immune dysregulation, suggesting actionable targets for combating sleep-related inflammatory disorders.}, archive = {J_ADVS}, author = {Ren Zhou and Keyun Li and Xiezong Hu and Shuhao Fan and Yuxuan Gao and Xiaoshu Xue and Yu Bu and Haoyi Zhang and Yili Wang and Chunjiao Wei and Shangrong Zhang and Zhongwen Xie and Chao Liu and Peng Chen and Zongjun Yin and Dalong Ren}, doi = {10.1002/advs.202504028}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e04028}, shortjournal = {Adv. Sci.}, title = {Sleep deprivation activates a conserved lactate-H3K18la-RORα axis driving neutrophilic inflammation across species}, volume = {12}, year = {2025}, }
• (2025). RelA inhibits embryonic myogenesis by coordinately regulating a novel distal enhancer of myogenin. ADVS, 12(38), e03712. (www)

  @article{ , abstract = {Skeletal muscle is crucial for lifelong metabolic health, with its development initiating during embryogenesis and guiding later growth. Single-cell RNA sequencing of E13.5 mouse embryos suggests that maternal obesity impairs embryonic myogenesis, primarily during myotube formation, and is correlated with the downregulation of myogenin ( Myog) expression. Spatial transcriptomic sequencing further confirms these findings. Conversely, maternal obesity induces the upregulation of RelA, a transcription factor and inflammatory signaling effector, in the myogenic cells of obese embryos. Additionally, single-cell ATAC sequencing suggests that a cis-regulatory region, located 4 kb proximal to the Myog promoter, exhibits coordinated expression with Myog and acts as an enhancer of Myog . In obese embryonic myogenic cells, RelA is recruited to this region, inhibiting Myog expression and myotube formation. Notably, in vitro RelA knockdown or inhibition rescues Myog expression and promotes myogenic differentiation. Similarly, metformin treatment of obese mothers restores embryonic Myog expression and myogenesis by suppressing RelA. Together, the multi-omics analyses demonstrate that RelA targets a distal Myog enhancer to coordinately inhibit Myog expression and embryonic myogenesis.}, archive = {J_ADVS}, author = {Md Nazmul Hossain and Yao Gao and Sharmeen Islam and Li-Wei Chen and Xinrui Li and Zhongyun Kou and Nathan C Law and Jeanene Marie de Avila and Mei-Jun Zhu and Min Du}, doi = {10.1002/advs.202503712}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e03712}, shortjournal = {Adv. Sci.}, title = {RelA inhibits embryonic myogenesis by coordinately regulating a novel distal enhancer of myogenin}, volume = {12}, year = {2025}, }
• (2025). Refractive index-corrected light-sheet microscopy for macro-view cardiovascular imaging. ADVS, 12(38), e03684. (www)

  @article{ , abstract = {Light-sheet fluorescence microscopy (LSFM) enables rapid data acquisition with minimal phototoxicity, while optical clearing reduces light scattering by matching sample and imaging medium refractive indices (RIs). Emerging clearing methods extend from cells and organoids to entire organs and organisms, prompting macro-view LSFM microscopes with macro-objectives for low-magnification imaging of larger specimens at adequate resolution. In cardiovascular studies, multiple organs often require imaging, yet clearing protocols optimized for different organs alter the sample RIs inconsistently. Standard-size dipping objectives use correction collars for RI adaptation, but macro-objectives, owing to their large size and long working distances, are typically dry lenses lacking built-in RI correction. An RI-corrected (rc)-LSFM macro-view system addresses this limitation by accommodating a broad range of RI values. By integrating axial sweeping, multi-view imaging, and a closed quartz chamber, the rc-LSFM improves field of view (up to ≈8.8 mm), isotropy, spatial resolution (≈3 µm), and operational safety. It effectively visualizes microvascular networks in zebrafish embryos and post-natal mouse retina, traces the stem cell lineage of cardiomyocytes in mouse embryos, and reveals sympathetic nerve innervation in adult mouse aorta. The rc-LSFM macro-view system is compatible with various optical clearing protocols for multi-scale imaging with high isotropy and spatial resolution.}, archive = {J_ADVS}, author = {Enbo Zhu and Yaran Zhang and Peng Zhao and Jae Min Cho and Zhaoqiang Wang and Yan-Ruide Li and Jing Wang and Samuel Margolis and Shaolei Wang and Lili Yang and Alison Chu and Yuhua Zhang and Liang Gao and Tzung K. Hsiai}, doi = {10.1002/advs.202503684}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e03684}, shortjournal = {Adv. Sci.}, title = {Refractive index-corrected light-sheet microscopy for macro-view cardiovascular imaging}, volume = {12}, year = {2025}, }
• (2025). Cellular adaptation to mechanical stress emerges via cell shrinkage triggered by nonlinear calcium elevation. ADVS, 12(38), e03659. (www)

  @article{ , abstract = {Organisms constantly encounter unpredictable environmental perturbations, necessitating adaptation to maintain homeostasis. However, the fundamental principles by which organisms identify specific cues and transition to an adaptive state remain unclear. Here, using a mouse mechanical ventilation model and a cell stretch model, it is found that the cellular adaptation to mechanical stress can be induced by applying low amplitude stretches to cells, and demonstrate that the adaptation emerges once a defined stretch threshold is reached. This adaptive state is marked by transient cell shrinkage and reduced membrane tension. Mechanistically, guided by a mathematical model of intracellular Ca 2+ dynamics, it is found that when stretch reaches a critical amplitude, it induces Ca 2+ -dependent positive feedback, leading to nonlinear Ca 2+ elevation. This activates scramblase Anoctamin-6, promoting extracellular vesicle-mediated membrane cholesterol efflux. The reduction in membrane cholesterol subsequently activates volume-regulated anion channels, leading to cell shrinkage and the establishment of mechanical adaptation. These findings reveal a threshold-dependent mechanism for mechanical adaptation emergence, and propose a promising strategy to develop targeted interventions in mechanical stress-related disorders.}, archive = {J_ADVS}, author = {Zhengyan Wang and Zihan Li and Lei Wang and Haitao Zhang and Xiaoshan Yang and Lili Bao and Geng Dou and Lili Ren and Yajing Fu and Lan Li and Shengkai Gong and Yang Zhou and Feng Ding and Lu Yu and Haotian Luo and Yao Liu and Fuyang Zhang and Hui Yu and Siying Liu and Xueming Liu and Fulan Wei and Shiyu Liu}, doi = {10.1002/advs.202503659}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e03659}, shortjournal = {Adv. Sci.}, title = {Cellular adaptation to mechanical stress emerges via cell shrinkage triggered by nonlinear calcium elevation}, volume = {12}, year = {2025}, }
• (2025). Enhanced brain-heart connectivity as a precursor of reduced state anxiety after therapeutic virtual reality immersion. ADVS, 12(38), e03606. (www)

  @article{ , abstract = {State anxiety involves transient feelings of tension and nervousness in response to threats, which can escalate into anxiety disorders if persistent. Despite treatments, 30%–50% of individuals show limited improvement, and neurophysiological mechanisms of treatment responsiveness remain unclear, requiring the development of objective biomarkers. In this study, multimodal electrophysiological parameters are monitored: heart rate variability (high frequency (HF), low frequency (LF), LF/HF ratio), EEG beta and alpha relative power, and brain-to-heart connectivity in participants with real-life state anxiety. Participants underwent a therapeutic intervention combining virtual-reality immersion, hypnotic script, and a breath control exercise. Real-life state anxiety is captured using the State-Trait Anxiety Inventory Form Y1 (STAI-Y1) scale before and after the intervention. Reduced anxiety is observed immediately after the intervention in 16 out of 27 participants. While all participants, independently of their STAI-Y1 score, showed increased heart rate variability (HRV) low frequency power, only treatment-responders displayed increased overall autonomic tone (high and low frequency HRV), increased midline beta power and brain-to-heart connectivity. Notably, the LF/HF ratio showed a significant linear relationship with anxiety reduction, with higher ratios linked to greater therapeutic response. These findings suggest that increased cognitive regulation of brain-to-heart connectivity can serve as a biomarker for therapeutic efficacy, with elevated midline beta power facilitating improved cardiac tone in responders.}, archive = {J_ADVS}, author = {Idil Sezer and Paul Moreau and Mohamad El Sayed Hussein Jomaa and Valérie Godefroy and Bénédicte Batrancourt and Richard Lévy and Anton Filipchuk}, doi = {10.1002/advs.202503606}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e03606}, shortjournal = {Adv. Sci.}, title = {Enhanced brain-heart connectivity as a precursor of reduced state anxiety after therapeutic virtual reality immersion}, volume = {12}, year = {2025}, }
• (2025). Sparse nanocrystals enable ultra-low coercivity and remarkable mechanical robustness in high-entropy amorphous alloy. ADVS, 12(38), e03546. (www)

  @article{ , abstract = {Ferromagnetic high-entropy alloys (HEAs) are known for their excellent mechanical properties, which are attributed to their abundant ordered structures. However, they often exhibit compromised soft magnetic properties, which restrict their applications in modern electronics. In this study, an order-modulation strategy is introduced to overcome this limitation by constructing an amorphous-nanocrystalline transitional structure in a ferromagnetic HEA system. Subsequently, FeCoNiAlTaSiB high-entropy sparse nanocrystals alloys are developed that possess fine nanocrystals sparsely dispersed in an amorphous matrix. This allows the resultant alloys to combine an ultra-low coercivity (0.3 A m −1 ) with remarkable mechanical toughness, achieving a synergistic enhancement of the mechanical robustness and soft magnetic properties. This remarkable mechanical-magnetic synergy is attributed to the presence of numerous crystal-like orders (<2 nm), regular magnetic-domain structures, and minimized magnetic anisotropy. Moreover, the proposed order-modulation strategy successfully extend structural control across the entire order space, from amorphous to crystalline, providing a new paradigm for designing advanced soft magnetic materials with balanced mechanical and magnetic properties.}, archive = {J_ADVS}, author = {Lichen Liu and Liliang Shao and Yan Ma and Zhilin Wen and Jing Zhou and Yuqiang Yan and Weiming Yang and Haibo Ke and Weihua Wang}, doi = {10.1002/advs.202503546}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e03546}, shortjournal = {Adv. Sci.}, title = {Sparse nanocrystals enable ultra-low coercivity and remarkable mechanical robustness in high-entropy amorphous alloy}, volume = {12}, year = {2025}, }
• (2025). Enhancing cycle stability in LiNiO2 with phase transition suppression via crystalline disordered surface layer. ADVS, 12(38), e03476. (www)

  @article{ , abstract = {Ni-rich layered oxides are promising cathode materials for lithium-ion batteries but require improved stability to meet performance demands. To address this, doping and surface modification are commonly employed stabilization strategies, each offering distinct benefits. Doping primarily suppresses phase transitions, thereby reducing volume changes, while surface coatings protect the material by minimizing continuous reactions with electrolytes during cycling. Consequently, these approaches are often used in combination to enhance material stability. This study demonstrates that a crystalline disordered surface layer can effectively suppress structural changes without doping. Notably, the thickness of the disordered surface layer is successfully controlled during synthesis for the first time. The results reveal that the formation rate of the layered structure plays a critical role in controlling the rock-salt disordered surface layer. Although a thicker crystalline disordered surface layer in single-crystal LiNiO 2 resulted in a slight capacity reduction, it exhibits significantly improved capacity retention, maintaining up to 84% of its capacity after 500 cycles in a full-cell test, while also substantially reducing voltage decay. This study provides insights, demonstrating that well-controlled surface modification can simultaneously protect the surface and mitigate structural changes, paving the way for the development of stable cathode materials.}, archive = {J_ADVS}, author = {Sooyeon Choi and Dong-hee Lee and Yonghyeon Kwon and Maxim Avdeev and Seok Hyun Song and Minki Kim and Sehyun Kim and Seung-yong Lee and Hyungsub Kim and Minkyung Kim}, doi = {10.1002/advs.202503476}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e03476}, shortjournal = {Adv. Sci.}, title = {Enhancing cycle stability in LiNiO2 with phase transition suppression via crystalline disordered surface layer}, volume = {12}, year = {2025}, }
• (2025). A multi-property optimizing generative adversarial network for de novo antimicrobial peptide design. ADVS, 12(38), e03443. (www)

  @article{ , abstract = {Antimicrobial peptides (AMPs) play a crucial role in developing novel anti-infective drugs due to their broad-spectrum antimicrobial activity and lower likelihood of causing bacterial resistance. However, laboratory synthesis of AMPs is tedious and time-consuming. Existing computational methods have limited capability in optimizing multiple desired properties simultaneously. Here, a Multi-Property Optimizing Generative Adversarial Network (MPOGAN) is proposed to iteratively learn the relationship between peptides and multi-properties with a dynamically updated dataset. With the increase of the dataset quality, the ability of the model to design AMPs with multiple desired properties is improved. Through extensive computational tests, MPOGAN exhibits superior performance in generating AMPs with multiple desired properties, including potent antimicrobial activity, reduced cytotoxicity, and increased diversity. Ten designed AMPs are chemically synthesized, nine of which exhibited antimicrobial activity and low cytotoxicity. Notably, two of these peptides showed potent broad-spectrum antimicrobial activity coupled with reduced cytotoxicity, highlighting their potential for downstream applications.}, archive = {J_ADVS}, author = {Jiaming Liu and Tao Cui and Tao Wang and Lishan Lin and Xi Zeng and Dazhi Lu and Shaoqing Jiao and Jun Wang and Xiaoyan Li and Shuyuan Xiao and Dongna Xie and Xuecheng Wang and Yongtian Wang and Xuequn Shang and Yinbo Niu and Zhongyu Wei and Jiajie Peng}, doi = {10.1002/advs.202503443}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e03443}, shortjournal = {Adv. Sci.}, title = {A multi-property optimizing generative adversarial network for de novo antimicrobial peptide design}, volume = {12}, year = {2025}, }
• (2025). Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate amygdala regulation and brain-wide fear representations. ADVS, 12(38), e03251. (www)

  @article{ , abstract = {Accumulating evidence from animal and human studies suggests a fear-regulating potential of the neuropeptide oxytocin (OT), yet the clinical translation into novel interventions for pathological fear requires a behavioral and neurofunctional characterization under close-to-real-life conditions. Here, we combined a naturalistic fMRI-design that elicited strong and immersive fear experience in social and non-social contexts with a preregistered between-subjects randomized double-blind placebo-controlled intranasal OT trial (24 IU, n =  67 healthy men). OT selectively reduced subjective fear in social contexts but not in non-social contexts. On the neural level OT enhanced left middle cingulate cortex (lMCC) activation and its functional connectivity with the contralateral amygdala, with both neural indices significantly and inversely associated with subjective fear following OT. On the network level, OT enhanced communication between the dorsal attention network (DAN) with the fronto-parietal (FPN) and the default-mode network (DMN), and modulated brain-wide communication patterns. Utilizing an independent activity-connectivity neuromarker for fear in naturalistic contexts (CAFE) confirmed that OT attenuated brain-wide fear expressions. Findings indicate an ecologically valid and socially specific fear-reducing effect of OT, highlighting its promise as a treatment option for disorders characterized by excessive fear in social situations.}, archive = {J_ADVS}, author = {Kun Fu and Shuyue Xu and Zheng Zhang and Dan Liu and Ting Xu and Yuan Zhang and Feng Zhou and Xiaodong Zhang and Chunmei Lan and Junjie Wang and Lan Wang and Jingxian He and Keith M Kendrick and Bharat Biswal and Dezhong Yao and Zhen Liang and Weihua Zhao and Benjamin Becker}, doi = {10.1002/advs.202503251}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e03251}, shortjournal = {Adv. Sci.}, title = {Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate amygdala regulation and brain-wide fear representations}, volume = {12}, year = {2025}, }
• (2025). The probiotic parabacteroides johnsonii ameliorates metabolic disorders through promoting BCAAs to BSCFAs conversion. ADVS, 12(38), e02624. (www)

  @article{ , abstract = {The gut bacterium Parabacteroides spp. is increasingly recognized for its therapeutic potential in treating metabolic disorders. However, the role of Parabacteroides johnsonii in metabolic disorders is never reported. Here, this study finds that the abundance of P. johnsonii in the feces is negatively correlated with the blood glucose and lipid levels of obese patients. Oral administration of live P. johnsonii improved the metabolic dysfunction in high fat diet (HFD)-fed mice, accompanied by the alleviation of leaky gut and the systemic inflammation. P. johnsonii enhanced the catabolism of branched-chain amino acids (BCAAs) to branched-chain short-chain fatty acids (BSCFAs) in gut. Particularly, the conversion of valine to isobutyrate is correlated to the symptoms of obese patients. Isobutyrate intervention mirrored the favorable effects of P. johnsonii on HFD-fed mice. Isobutyrate increased H3K14 acetylation at Fgf1b promoters and activated its transcription through inhibition of HDAC3 in colon, thereby maintaining the intestinal barrier integrity. The natural product stachyose exerted anti-obesity effects by enhancing the growth of P. johnsonii . These results offered insights into the mechanisms underlying the potential of P. johnsonii , isobutyrate, and stachyose in treating metabolic disorders.}, archive = {J_ADVS}, author = {Yimeng Chen and Shujun Jiang and Haolu Wang and Mengzhen Si and Haixia Wu and Xinyi Liang and Shenmeng Yao and Yanliang Zhang and Xiaodong Wen and Jie Yang}, doi = {10.1002/advs.202502624}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e02624}, shortjournal = {Adv. Sci.}, title = {The probiotic parabacteroides johnsonii ameliorates metabolic disorders through promoting BCAAs to BSCFAs conversion}, volume = {12}, year = {2025}, }
• (2025). Abnormal β-hydroxybutyrylation modification of ARG1 drives reprogramming of arginine metabolism to promote the progression of colorectal cancer. ADVS, 12(38), e02402. (www)

  @article{ , abstract = {The abnormal arginine metabolism is characteristic of tumor cell metabolism in colorectal cancer (CRC). However, the mechanisms underlying arginine metabolic reprogramming and how altered metabolism in turn enhances CRC tumorigenicity are poorly understood. Protein post-translational modifications (PTMs) are crucial for regulating protein function, activity, and interactions. Here, the study reports that arginine levels are elevated in CRC, accompanied by the high expression of arginase-1 (ARG1) but low levels of ARG1 β-hydroxybutyrylation (Kbhb) and its oncogenic role in CRC in a catalytic-activity-independent manner. Mechanistically, low-level ARG1-Kbhb-induced arginine metabolic reprogramming by decreasing the interaction of ARG1 with SLC3A2 in CRC cells inhibits the efflux of arginine, thereby increasing intracellular arginine levels to promote tumorigenicity. P300 is identified as the “writer” of Kbhb. Inducing ARG1-Kbhb at the Lys313 residue by β-hydroxybutyrate (BHB) promotes the interaction of ARG1 with SLC3A2, resulting in the efflux of arginine in CRC cells. Together, these findings reveal valuable insights into arginine metabolism reprogramming involving the ARG1-Kbhb/P300/SLC3A2 signaling axis, thereby bridging the connection between metabolic reprogramming and PTMs, which may shed light on the therapeutic potential of combining BHB with ARG1 inhibitor through the conventional enzymatic role and nonenzymatic metabolic function of ARG1 for CRC.}, archive = {J_ADVS}, author = {Chuman Lin and Zhiyang Li and Xiaotong Zhu and Wanbing Zhou and Xiansheng Lu and Jiali Zheng and Jie Lin}, doi = {10.1002/advs.202502402}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e02402}, shortjournal = {Adv. Sci.}, title = {Abnormal β-hydroxybutyrylation modification of ARG1 drives reprogramming of arginine metabolism to promote the progression of colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Lithium exposure causes trophoblast cuproptosis by upregulating FOXO1/STEAP4 axis in unexplained miscarriage. ADVS, 12(38), e02139. (www)

  @article{ , abstract = {Lithium (Li) batteries have been used worldwide, but few are recycled, thus, the waste Li has been widely spread into the environment and finally accumulated in human body. Cuproptosis is a newly reported Cu-dependent and programmed cell death form. The unclear pathogenesis of unexplained miscarriage (UM) largely restricts its clinical treatment and global human reproduction. In this study, a UM case-control study shows that Li levels in serum or villous tissues, the levels of cuproptosis in villous tissue, and UM are positively associated. Li-exposed mouse models further confirm that Li exposure causes placental cuproptosis to induce miscarriage. Mechanistically, Li exposure up-regulates FOXO1 expression levels and thus promotes FOXO1-mediated STEAP4 transcription, up-regulating STEAP4 levels. STEAP4 up-regulates intracellular Cu + ion levels and causes cuproptosis, which further induces miscarriage. The cellular mechanisms are consistent with those in UM villous tissues and Li-exposed mouse placental tissues. Finally, treatment with TTM to suppress cuproptosis or the therapeutic down-regulation of FOXO1 or STEAP4 could efficiently suppress placental cuproptosis and alleviate mouse miscarriage in the Li-exposed mouse models. Collectively, this study not only discovers new healthy risks of Li exposure and novel pathogenesis of Li-induced unexplained miscarriage but also reveals new biological targets for treatment against miscarriage.}, archive = {J_ADVS}, author = {Shuaishuai Xing and Yanbing Lin and Yi Sun and Xiaoping Yue and Qigang Fan and Jisheng Nie and Zhihong Zhang and Yajing Liu and Juntang Yang and Qingzheng Kang and Yanxin Wang and Haijun Yan and Chan Tian and Ying Chang and Huidong Zhang}, doi = {10.1002/advs.202502139}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e02139}, shortjournal = {Adv. Sci.}, title = {Lithium exposure causes trophoblast cuproptosis by upregulating FOXO1/STEAP4 axis in unexplained miscarriage}, volume = {12}, year = {2025}, }
• (2025). Progastrin promotes colorectal cancer stem cell-like properties via the receptor PZR. ADVS, 12(38), e02136. (www)

  @article{ , abstract = {The tumor microenvironment promotes cancer progression in part by supporting cancer stem cells (CSC). In colorectal cancer (CRC), progastrin (PG), an orphan growth factor secreted by tumor cells within the tumor and its microenvironment, maintains CSCs by unidentified mechanisms. Here, the orphan receptor Protein Zero-Related protein (PZR) is identified as an essential component of PG activity and demonstrated its utility as a therapeutic target. PZR is essential for growth of PG-expressing tumors, while genetic inactivation in mice of Mpzl1 , which encodes PZR, disrupted chemically-induced colon transformation. Mechanistically, PG binds cellular glycosylated and dimeric PZR and promotes SHP2/SRC/β-catenin-dependent CSC-like signaling. Blocking PZR by monoclonal antibodies inhibited PG-dependent expansion of tumoroids derived from murine intestinal tumors and patient-derived CRC cell lines, while in mice, it reduced adenoma formation triggered by Apc loss in stem cells and disrupted the tumor-initiating capacity of PG-expressing CRC cells. High GAST (which encodes PG) and MPZL1 transcript levels in primary colon cancer patients is predictive of worse prognosis. Collectively, these findings support the inhibition of PZR as a potential targeted treatment of PG-expressing CRC.}, archive = {J_ADVS}, author = {Julie Nguyen and Marie Lafitte and Maud Barbery and Kevin Espie and Maya Jeitany and Romain Larive and Jihane Vitre and Conception Paul and Yvan Boublik and Elise Fourgous and Valérie Simon and Audrey Sirvent and Madeline Neiveyans and Steeve Thirard and Lucile Bansard and Morgan Maillard and Nathalie Coutry and Jacques Colinge and Philippe Jay and Pierre Martineau and Michael Hahne and Julie Pannequin and Serge Roche}, doi = {10.1002/advs.202502136}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e02136}, shortjournal = {Adv. Sci.}, title = {Progastrin promotes colorectal cancer stem cell-like properties via the receptor PZR}, volume = {12}, year = {2025}, }
• (2025). UV-triggered cascading degradation of silicone elastomer via self-fluoride amplification. ADVS, 12(38), e02056. (www)

  @article{ , abstract = {UV-triggered on-demand degradable materials offering accurate and remote control of material lifetime, are emerging as vital element for applications such as self-destructive soft robotics for hardware security, triggerable transient electronics, and data protection systems. However, previously reported UV-initiated materials face challenges, including i) poor scalability with limited penetration depth of UV light, ii) incompatibility with UV-blocking materials, preventing generation of reactive moieties for degradation. This study proposes a locally UV-triggered, synergistic F – self-amplification system that enables rapid, complete, and on-demand degradation of silicone elastomer composite, even with embedding UV-blocking particles. This is achieved by introducing a self-immolative F – amplifying molecule (FIA) and photo-induced F – generator, diphenyliodonium hexaflurophosphate (DPI-HFP) into the silicone elastomer which amplifies F – through F – -induced network of reactions. The F – amplification mechanism is validated through spectroscopic, thermal and chemical analysis, and the composite shows excellent mechanical properties with elongation over 450% and low Young's modulus of ≈60 kPa. Rapid UV-triggered degradation occurs within 60 min even with embedding 33 wt.% of magnetic particle. Furthermore, a magnetically actuated soft robot is fabricated exhibiting various motions and on-demand degradation, underscoring the potential of this material platform for expanding the scope for UV-triggered degradable system across various fields.}, archive = {J_ADVS}, author = {Yoon-Nam Kim and Woojin Jeon and Min-Ha Oh and Hee-June Seo and Min Sang Kwon and Seung-Kyun Kang}, doi = {10.1002/advs.202502056}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e02056}, shortjournal = {Adv. Sci.}, title = {UV-triggered cascading degradation of silicone elastomer via self-fluoride amplification}, volume = {12}, year = {2025}, }
• (2025). Distributed temporal coding of visual memory categories in human hippocampal neurons revealed by an interpretable decoding model. ADVS, 12(38), e02047. (www)

  @article{ , abstract = {The hippocampus is crucial for forming new episodic memories. While its role in encoding spatial and temporal information (where and when) is well understood, how it encodes objects (what) remains unclear due to the high dimensionality of object space. Rather than encoding each object separately, the hippocampus may encode object categories to reduce complexity. Here, an experimental-modeling approach to investigate how the hippocampus encodes visual memory categories in humans is developed. Spikes are recorded from hippocampal CA3 and CA1 neurons in 24 epilepsy patients performing a delayed match-to-sample task involving five image categories. An interpretable memory decoding model is employed to decode memory categories from hippocampal spiking activity and identify the spatio-temporal characteristics of hippocampal encoding. Using this model, the optimal temporal resolutions for decoding each visual memory category per neuron are estimated. Results indicate that visual memory categories can be decoded from hippocampal spike patterns, supporting the presence of category-specific coding. Hippocampal neuron ensembles encode memory categories in a distributed manner, akin to a population code, while individual neurons use a temporal code. Additionally, CA3 and CA1 neurons exhibit similar and redundant memory category information, likely due to strong and diffuse feedforward synaptic connections from CA3 to CA1 regions.}, archive = {J_ADVS}, author = {Xiwei She and Bryan J. Moore and Brent M. Roeder and George Nune and Brian S. Robinson and Brian Lee and Susan Shaw and Hui Gong and Christianne N. Heck and Gautam Popli and Daniel E. Couture and Adrian W. Laxton and Vasilis Z. Marmarelis and Samuel A. Deadwyler and Charles Liu and Theodore W. Berger and Robert E. Hampson and Dong Song}, doi = {10.1002/advs.202502047}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e02047}, shortjournal = {Adv. Sci.}, title = {Distributed temporal coding of visual memory categories in human hippocampal neurons revealed by an interpretable decoding model}, volume = {12}, year = {2025}, }
• (2025). Leptin aggravates thoracic aortic dissection through impairment of energy metabolism in nrip2+ smooth muscle cells. ADVS, 12(38), e02027. (www)

  @article{ , abstract = {Obesity is a significant risk factor for thoracic aortic dissection (TAD), as supported by UK Biobank data showing obese individuals have a higher risk of TAD. The study investigates leptin, a hormone elevated in obesity, and finds that hyperleptinemia is common in TAD patients, suggesting its role in disease pathogenesis. Using leptin-knockout mice, it is demonstrated that exogenous leptin exacerbates TAD by promoting phenotypic transitions in vascular smooth muscle cells (VSMCs). These adverse effects are reversible with pharmacologic leptin blockade, indicating potential therapeutic benefits. Single-cell RNA sequencing reveals a novel smooth muscle cells (SMC) cluster, Nrip2 + , in the aorta, with a distinct contractile gene profile. Increased Nrip2 + VSMCs are linked to enhanced mitochondrial energy metabolism. Elevated Nrip2 + VSMCs inhibit the leptin-induced transition from a contractile to a synthetic phenotype, reducing TAD incidence. The findings suggest that high blood leptin levels contribute to the increased TAD risk in obese individuals by suppressing Nrip2 + SMCs, leading to abnormal mitochondrial metabolism and VSMC phenotypic transitions. Thus, targeting leptin to boost Nrip2 + VSMC metabolic activity is a promising strategy for TAD prevention and treatment.}, archive = {J_ADVS}, author = {Ling Chen and Yujie Zhu and Xi Yang and JiangBin Wu and Keyuan Chen and Wuqing Huang and Lu Fang and Qi Zhang and Jie Chen and Jianing Gao and Huanhuan Cao and Meifang Wu and Zhihuang Qiu and Yuling Zhang and Yue Shen and Qiuyu Huang and Zhiyong Lin and Lemin Zheng and Liangwan Chen}, doi = {10.1002/advs.202502027}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e02027}, shortjournal = {Adv. Sci.}, title = {Leptin aggravates thoracic aortic dissection through impairment of energy metabolism in nrip2+ smooth muscle cells}, volume = {12}, year = {2025}, }
• (2025). A glycoproteome data mining strategy for characterizing structural features of altered glycans with thymic involution. ADVS, 12(38), e02013. (www)

  @article{ , abstract = {Glycosylation plays an important role in regulating innate and adaptive immunity. With promising advances in structural and site-specific glycoproteomics, how to thoroughly extract important information from these multi-dimensional data has become another unresolved issue. The present study reports a comprehensive data mining strategy to systematically extract overall and altered glycan features from quantitative glycoproteome data. By applying the strategy to investigation of thymic involution, the study not only presents a high-resolution glycoproteome map of the mouse thymus, displaying distinct glycan structure patterns among immune-relevant cellular components, but also uncovers four major altered glycan features associated with thymic involution, including elevated LacdiNAc mainly on the MHC class I complex, increased sialoglycans that perform multiple immune functions, down-regulated bisecting glycans mostly linked to a sole GlcNAc branch, as well as possible shifts of glycan structures at the same glycosites. Regulatory network analyses further reveal the coordinated interactions of altered glycans with upstream regulators, including glycosyltransferases, glycosidases, and glycan-binding proteins, as well as downstream signaling pathways. These data offer valuable resources for future functional studies on glycosylation and the mechanistic investigation of thymic involution, supporting the strategy as a powerful tool for in-depth mining of structural and site-specific glycoproteome data from various biomedical samples.}, archive = {J_ADVS}, author = {Zhida Zhang and Yongqi Wu and Ke Hou and Yiwen Zhang and Lin Chen and Muyao Yang and Zhehui Jin and Yongchao Xu and Yingjie Zhang and Yinli Cai and Jiayu Zhao and Shisheng Sun}, doi = {10.1002/advs.202502013}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e02013}, shortjournal = {Adv. Sci.}, title = {A glycoproteome data mining strategy for characterizing structural features of altered glycans with thymic involution}, volume = {12}, year = {2025}, }
• (2025). STAT6 activation exacerbates ferroptosis in airway epithelium by inhibiting PRKN-mediated mitophagy in pulmonary fibrosis. ADVS, 12(38), e01718. (www)

  @article{ , abstract = {Pulmonary fibrosis (PF) remains a clinically intractable condition with limited therapies. Ferroptosis has emerged as a critical driver of PF. The previous study demonstrates that increased secretion of tissue plasminogen activator from ferroptotic airway epithelial cells contributes to PF progression in a paracrine manner. Herein, the indispensable role of signal transducer and activator of transduction 6 (STAT6) is further elucidated in maintaining airway epithelial homeostasis during PF and uncovers a novel mechanism by which STAT6 regulates mitophagy to modulate ferroptosis. Specifically, mitophagy is induced during PF along with STAT6 activation, and deficiency of STAT6 significantly alleviates epithelial ferroptosis and PF. Mechanistically, STAT6 directly binds to the parkin RBR E3 ubiquitin protein ligase (PRKN) promoter region at the site (−990 to −976), inhibiting PRKN transcription and thereby impairing mitophagy. Consistently, lentivirus-mediated PRKN interference in both wild-type and STAT6 knockout mice aggravates ferroptosis and PF. Furthermore, virtual screening identifies rifabutin as a potential STAT6 inhibitor, that exhibits therapeutic effects against PF both in vivo and in vitro. Collectively, these findings reveal an unreported mechanism by which STAT6 promotes PF by inhibiting PRKN-mediated mitophagy in the airway epithelium. Rifabutin is further identified and validated as a promising STAT6 inhibitor to alleviate PF, offering new insights into therapy development.}, archive = {J_ADVS}, author = {Youjing Yang and Guangbin Huang and Tao Zhang and Yi Ling and Junyu Jiang and Dingyuan Du and Yu Ma and Shasha Tao}, doi = {10.1002/advs.202501718}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e01718}, shortjournal = {Adv. Sci.}, title = {STAT6 activation exacerbates ferroptosis in airway epithelium by inhibiting PRKN-mediated mitophagy in pulmonary fibrosis}, volume = {12}, year = {2025}, }
• (2025). Ligilactobacillus murinus and lactobacillus johnsonii suppress macrophage pyroptosis in atherosclerosis through butyrate-GPR109A-GSDMD axis. ADVS, 12(38), e01707. (www)

  @article{ , abstract = {Gut microbiota and their metabolites are remarkable regulators in atherosclerosis. Oral drugs such as aspirin have recently been found to modulate the gut microbiome. However, the roles of drug-microbiota-metabolite interactions in atherosclerosis have not been explored. Herein, two gut probiotics, Ligilactobacillus murinus ( L. murinus ) and Lactobacillus johnsonii ( L. johnsonii ), are identified from mouse models and human cohorts, which are positively correlated with aspirin usage. Specifically, the eradication of these two species eliminated aspirin's anti-atherosclerotic effects, while their transplantation exhibited therapeutic effects against atherosclerosis. Integrative analysis of metagenomic and metabolomic data showed that elevated levels of butyrate are associated with these two species. Mechanically, L. murinus and L. johnsonii form symbiotic networks with butyrate-producing bacteria such as Allobaculum . This study confirmed that gut microbes produce butyrate, which helps preserve the gut barrier and prevents the leakage of lipopolysaccharides. By integrating molecular biology and single-cell sequencing data, G protein-coupled receptor 109A (GPR109A) is confirmed as the direct target of butyrate. Through the activation of GPR109A, butyrate produced by L. murinus and L. johnsonii suppressed the expression of Gasdermin D (GSDMD) in the pyroptosis of macrophages during atherosclerosis. These findings offer novel insights into the drug-microbiota axis that can be targeted to improve the treatment of atherosclerosis.}, archive = {J_ADVS}, author = {Rui Hua and Ning Ding and Yiming Hua and Xiaoke Wang and Yu Xu and Xiangrui Qiao and Xue Shi and Ting Bai and Ying Xiong and Xiaozhen Zhuo and Chong Fan and Juan Zhou and Yue Wu and Junhui Liu and Zuyi Yuan and Ting Li}, doi = {10.1002/advs.202501707}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e01707}, shortjournal = {Adv. Sci.}, title = {Ligilactobacillus murinus and lactobacillus johnsonii suppress macrophage pyroptosis in atherosclerosis through butyrate-GPR109A-GSDMD axis}, volume = {12}, year = {2025}, }
• (2025). Oral engineered extracellular vesicles based on ion exchange strategy for multipronged management of wilson's disease complicated with reproductive dysfunction therapy. ADVS, 12(38), e01689. (www)

  @article{ , abstract = {Wilson's disease (WD), as a typical disease of excessive Cu 2+ deposition, is characterized by disorders of copper metabolism in the brain and thereby damaging the reproductive system. Conventional interventions using copper chelators can temporarily reduce intracellular copper (in-copper), but continuous re-entry of extracellular copper (ex-copper) into cells results in suboptimal therapy. Effective therapy requires multipronged copper metabolism management. Here, an orally administered, engineered Ganoderma-derived extracellular vesicle (CZGE) is developed for synergistic in/ex-copper regulation. Specifically, CZGE is designed by co-fusing Ganoderma-derived extracellular vesicle (GEVs) and targeted nanomicelles containing zinc-curcumin (Zn-Cur) complex (ZCNs). CZGE, with β -glucan-enriched GEVs and kisspeptin-10-modified ZCNs, can effectively penetrate intestinal and brain barriers after oral administration to target hypothalamic neurons.After internalization, Zn-Cur released from CZGE replaces excess Cu 2+ to form copper-curcumin (Cu-Cur) and release Zn 2+ via ion exchange. Cu-Cur reduces in-copper and neuroinflammation via the Nrf2/NLRP3 pathway, while Zn 2+ inhibits ex-copper influx by activating zinc transporter 1. In WD mice, CZGE alleviates hypothalamic copper deposition, activates ERK1/2 phosphorylation, and repairs reproductive dysfunction by modulating the hypothalamic-pituitary-testicular axis. It first reveals a targeted nanomedicine based on ion exchange that multipronged management in-copper and ex-copper, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.}, archive = {J_ADVS}, author = {Tingting Wang and Wengui Lu and Zhifei Cheng and Luyao Wang and Zhenzhen Jiang and Yike Yue and Pengyu Jiang and Zehua Xia and Lei He and Fengying Wang and Limin Wu and Qi Wang and Hui Han}, doi = {10.1002/advs.202501689}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e01689}, shortjournal = {Adv. Sci.}, title = {Oral engineered extracellular vesicles based on ion exchange strategy for multipronged management of wilson's disease complicated with reproductive dysfunction therapy}, volume = {12}, year = {2025}, }
• (2025). Irisin-loaded cerium-containing mesoporous bioactive glass for effective immunomodulation and odontogenesis of dental pulp cells. ADVS, 12(38), e01567. (www)

  @article{ , abstract = {Recently, vital pulp therapy (VPT) has emerged as a promising strategy for dental pulp treatment because of the preservation of the pulp tissue. The efficacy of VPT relies on the use of VPT agents; however, commonly used VPT agents, including calcium hydroxide (CH), possess several limitations, such as dental pulp cells (DPCs) stimulation. In this study, we report the design of a novel VPT agent by loading Irisin onto cerium-containing mesoporous bioactive glass nanoparticles (Ce-MBGNs) to generate Irisin/Ce-MBGNs. Compared to CH, which do not exhibit any obvious anti-inflammatory effect, Irisin/Ce-MBGNs have been shown to enhance the function of mitochondria in macrophages, regulate the M2 polarization, significantly reduce the intracellular ROS level, and alleviate the expression of pro-inflammatory factors. Furthermore, the Irisin/Ce-MBGNs nanocomposite effectively preserved DPCs stemness and promoted the odontogenic differentiation of human DPCs. Results in in vivo experiments showed that Irisin/Ce-MBGNs could form thicker reparative dentin surrounding the perforation holes than CH. The superior treating efficacy of Irisin/Ce-MBGNs is attributed to the synergistic effects of both Irisin and cerium components for the effective immunomodulation and odontogenesis of DPCs. Hopefully, this work contributes to the design of more advanced VPT agents for future implementation in clinical use.}, archive = {J_ADVS}, author = {Mingxin Wang and Yuxin Yang and Jingyao Guo and Yan Chen and Xiaolin Lu and Guangdong Zhang and Yuli Wang and Minhui Yao and Yue Liu and Qian Ma}, doi = {10.1002/advs.202501567}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e01567}, shortjournal = {Adv. Sci.}, title = {Irisin-loaded cerium-containing mesoporous bioactive glass for effective immunomodulation and odontogenesis of dental pulp cells}, volume = {12}, year = {2025}, }
• (2025). RPL6 interacts with HMGCS1 to stabilize HIF-1α by promoting cholesterol production in hepatocellular carcinoma. ADVS, 12(38), e01373. (www)

  @article{ , abstract = {The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to analyze time-series transcriptomic data from a pulmonary metastasis HCC mouse model, it is revealed that the premetastatic phase occurred during the fourth week after implantation. A total of 142 DNB genes are identified as functionally important biomarkers for HCC metastasis, among which 60S ribosomal protein L6 (RPL6) is a core DNB member. RPL6 is significantly upregulated in HCC tissues with extrahepatic metastasis and is strongly correlated with poor prognosis in HCC patients. RPL6 promotes the invasion and metastasis of HCC cells, both in vitro and in vivo. Mechanistically, RPL6 directly binds to the HMGCS1 mRNA 3′UTR, a rate-limiting enzyme in cholesterol biosynthesis, thus increasing HMGCS1 mRNA stability and protein expression and subsequently elevating intracellular cholesterol level. Elevated cholesterol inhibits the ubiquitin-dependent degradation of HIF-1α, which further results in activation of HIF-1α signaling pathway. Together, this study provides new insights into the dynamic transcriptome profiles of HCC pulmonary metastasis and establishes an important role for the RPL6-HMGCS1-HIF-1α axis in HCC metastasis, suggesting potential prognostic biomarkers and therapeutic targets in HCC.}, archive = {J_ADVS}, author = {Minli Yang and Shengtao Cheng and Huiying Gu and Shan Zhong and Dapeng Zhang and Xin He and Weixian Chen and Haijun Deng and Jihua Ren and Peng Chen and Ming Tan and Hui Zhang and Fan Li and Zhenzhen Zhang and Yuan Hu and Juan Chen}, doi = {10.1002/advs.202501373}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e01373}, shortjournal = {Adv. Sci.}, title = {RPL6 interacts with HMGCS1 to stabilize HIF-1α by promoting cholesterol production in hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Template-free fabrication of single atom fe-based cathodes unlock high-performing anion-exchange membrane fuel cells. ADVS, 12(38), e01016. (www)

  @article{ , abstract = {Single-atom catalysts (SACs) possessing well-defined active sites of singular metal atoms have gained prominence in the field of electrocatalysis as they can be tuned to enhance activity and stability. In this study, a critical-raw-material (CRM)-free SAC is synthesized for the oxygen reduction reaction (ORR) in alkaline media by pyrolyzing polyimide nanoparticles and Fe without using a sacrificial template. Upon purification, the resulting catalyst demonstrates outstanding performance as cathodes in anion-exchange membrane fuel cells (AEMFCs) owing to sufficiently stabilized Fe single-atoms at the FeN 4 sites yielding a peak power density ( P max ) as high as ∼1.8 W cm −2 and specific power values up to 11.3 W ; the latter being the greatest reported among CRM-free cathode AEMFCs. The SAC also shows remarkable in situ durability under a very high current density of 1000 mA cm −2 , a first introduced here, with only a 2 mV h −1 decay. Most impressively, when the SAC is combined with a NiMo anode to test a completely CRM-free high-temperature (HT)-AEMFC at 118 °C, a P max of 372 mW cm −2 and limiting current density of ∼1.14 A cm −2 are achieved. This work represents a significant milestone in the development of durable SAC cathode catalysts for the next generation of CRM-free AEMFCs.}, archive = {J_ADVS}, author = {John C. Douglin and Hideo Notsu and Shinsuke Nagata and Sapir Willdorf-Cohen and Jinliu Zhong and Junya Ohyama and Jiawei Hu and Syeda M. Zahan and Andres O. Godoy and Changlai Wang and Oluwafemi Sanumi and Masayuki Tsushida and Karam Yassin and Jasna Jankovic and Charles E. Diesendruck and Yuta Nabae and Dario R. Dekel}, doi = {10.1002/advs.202501016}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e01016}, shortjournal = {Adv. Sci.}, title = {Template-free fabrication of single atom fe-based cathodes unlock high-performing anion-exchange membrane fuel cells}, volume = {12}, year = {2025}, }
• (2025). Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation-dependent tim-3 lysosomal sorting and degradation. ADVS, 12(38), e00971. (www)

  @article{ , abstract = {Palmitoylation is a fully reversible post-translational modification that regulates the functions of various proteins. While its dysregulation has been implicated in numerous pathological processes, there has been scarce researches on palmitoylation changes in proteins associated with recurrent pregnancy loss (RPL). Utilizing palmitoylation proteomics, 3262 proteins are identified with increased palmitoylation and 1577 proteins with decreased palmitoylation in the decidual immune cells from RPL patients compared to those from normal early pregnancies. Reduced palmitoylation by 2-bromopalmitate promoted decidual CD4 + T (dCD4 + T) cell tolerance and decrease the resorption rate of abortion-prone mice, suggesting that elevated palmitoylation level may be associated with RPL. The bioinformatics, proteomic, functional and mouse model studies revealed that T cell immunoglobulin domain and mucin domain-3 (Tim-3) is palmitoylated by ZDHHC3 on cysteine 9 residue. This palmitoylated-Tim-3 subsequently bound to sortilin and was directed to lysosome for degradation, leading to decreased expression of Tim-3 and the dysfunction of dCD4 + T cells, ultimately resulting in fetal loss. We elucidated a pivotal role for dynamic palmitoylation in RPL and uncovered a novel mechanism governing Tim-3 regulation. Given that Tim-3 dysregulation is frequently linked to RPL, our findings may have important implications for understanding the etiology of RPL and developing targeted therapy of RPL.}, archive = {J_ADVS}, author = {Liyuan Cui and Xinhang Meng and Yujie Luo and Jinfeng Qian and Fengrun Sun and Mingke Qiu and Songcun Wang}, doi = {10.1002/advs.202500971}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e00971}, shortjournal = {Adv. Sci.}, title = {Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation-dependent tim-3 lysosomal sorting and degradation}, volume = {12}, year = {2025}, }
• (2025). Type i interferon signaling augments autoimmunity in neuromyelitis optica spectrum disorder. ADVS, 12(38), e00942. (www)

  @article{ , abstract = {Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease characterized by anti-aquaporin 4 (AQP4) antibody-mediated astrocyte damage and subsequent demyelination. Prior attempts to treat NMOSD with interferon-beta (IFN-β), a disease-modifying therapy for multiple sclerosis, resulted in worsening of disease activity, with an unknown mechanism. Here, robust activation of the cGAS-STING-IFN-I signaling pathway is identified in myeloid cells in both the periphery and central nervous system. The abnormal IFN-I response gives rise to an increase in the number of AQP4 antigen-specific autoreactive T cells. Sting deficiency can significantly blunt the activation of AQP4-specific T cells, as well as the IFN-I activity in microglia, and attenuate astrocyte damage. Consequently, the clinical manifestation of NMOSD is ameliorated in a passive transfer mouse model of NMOSD. Further, treatment with STING inhibitor H151 alleviates the severity of NMOSD mouse models. These findings uncover the cGAS-STING-IFN-I pathway in promoting autoreactive T cells and establish a foundation for inhibiting this pathway as a new therapeutic revenue for NMOSD.}, archive = {J_ADVS}, author = {Tian-Xiang Zhang and Xiaoxiao Yang and Xue Gao and Xiaoshan Du and Xuegan Lian and Naiyuan Shao and Ye Liu and Zhenning Huang and Dongmei Jia and Alexander Y. L. Lau and Zhiguo Li and Zaal Kokaia and Fu-Dong Shi and Chao Zhang}, doi = {10.1002/advs.202500942}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e00942}, shortjournal = {Adv. Sci.}, title = {Type i interferon signaling augments autoimmunity in neuromyelitis optica spectrum disorder}, volume = {12}, year = {2025}, }
• (2025). Intestinal epithelial-derived USP13 alleviates colonic inflammation by suppressing GRP78-mediated endoplasmic reticulum stress. ADVS, 12(38), e00741. (www)

  @article{ , abstract = {Inflammatory bowel disease (IBD) is a chronic condition in which endoplasmic reticulum (ER) stress and subsequent apoptosis of intestinal epithelial cells play significant roles. E3 ubiquitin ligases and deubiquitinases are crucial in IBD pathophysiology by modulating protein ubiquitination. This study investigated the regulatory role of a deubiquitinase ubiquitin-specific peptidase 13 (USP13) in a DSS-induced colitis mouse model and explored the underlying mechanism. Intestinal epithelial-specific Usp13 knockout (USP13 IEKO ) mice were treated with DSS to induce colitis. Adeno-associated virus serotype 9 (AAV9) was constructed to overexpress UPS13 in colonic tissues. The results show that intestinal epithelial-specific USP13 knockout exacerbated DSS-induced colitis, linked to increased ER stress and apoptosis. Mechanistically, USP13 interacted with  GRP78, attenuating ER stress-induced apoptosis and maintaining intestinal barrier integrity by selectively removing K63-linked ubiquitin at lysine 327. Moreover, restoration of USP13 expression via AAV9 in USP13 IEKO mice attenuated DSS-induced colitis and preserved intestinal barrier integrity. Also, USP13 levels were reduced in ulcerative colitis patients compared to the healthy controls, highlighting its protective role in intestinal health. These findings underscore the protective role of the USP13-GRP78 axis in IBD and suggest that targeting USP13 through intestinal epithelial-specific gene therapy may be a potential therapeutic strategy for IBD.}, archive = {J_ADVS}, author = {Chenchen Qian and Chenghong Hu and Yong Xu and Wentao Xu and Zhe Wang and Wan Gan and Weiyang Tang and Lijiang Huang and Aleksandr V. Samorodov and Yi Wang}, doi = {10.1002/advs.202500741}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e00741}, shortjournal = {Adv. Sci.}, title = {Intestinal epithelial-derived USP13 alleviates colonic inflammation by suppressing GRP78-mediated endoplasmic reticulum stress}, volume = {12}, year = {2025}, }
• (2025). Carrier-free nanocapsule with dual-target capacity for synergistically restoring inflammatory microenvironment and microbiota dysbiosis in colitis. ADVS, 12(38), e00001. (www)

  @article{ , abstract = {Inflammatory bowel disease (IBD) is a chronic inflammatory disease with limited therapeutic outcomes. Macrophages are the key gatekeepers of intestinal immune homeostasis and have vital influence on IBD. Hence, macrophages are recognized as attractive targets to develop new therapeutic. However, the therapy development has proven challenging due to the malignant biological chain between macrophage immune hyperresponsiveness and dysbiosis of intestinal microflora. Herein, a carrier-free nano-drug, PCNPs@PEG-Man, with dual-targeting function, is produced due to IBD lesion-specific positive charge and high expression of mannose receptor. With super resistance against extreme intraluminal conditions, PCNPs@PEG-Man showes stable ROS-scavenging properties thereby. Notably, the dual-targeting strategy enhances the endocytosis efficiency and intestinal retention time of the drug, which is conducive to the downregulation of pro-inflammatory factors, upregulation of anti-inflammatory factors, and repair of the intestinal barrier. Additionally, it reshaped the dysbiosis of intestinal bacteria, revealing an optimized gut flora composition of probiotics. The mechanism of the carrier-free nano-drug mainly involves the elimination of oxidative stress, promoting macrophage M2 polarization, and restoring gut homeostasis. The synergistic effect inherent in this dual-targeting system presents an effective and safe approach to managing IBD, providing new insights into the treatment of intestinal ROS-mediated diseases associated with microbiota dysbiosis.}, archive = {J_ADVS}, author = {Yingjie Chen and Yuhan Gao and Kaiyuan Huo and Zhaofan Jin and Wenchao Wang and Xingjie Zan and Yanlong Liu and Limeng Zhu and Jianfeng Yang}, doi = {10.1002/advs.202500001}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {e00001}, shortjournal = {Adv. Sci.}, title = {Carrier-free nanocapsule with dual-target capacity for synergistically restoring inflammatory microenvironment and microbiota dysbiosis in colitis}, volume = {12}, year = {2025}, }
• (2025). Distributed temporal coding of visual memory categories in human hippocampal neurons revealed by an interpretable decoding model (Adv. sci. 38/2025). ADVS, 12(38), 71942. (www)

  @article{ , archive = {J_ADVS}, author = {Xiwei She and Bryan J. Moore and Brent M. Roeder and George Nune and Brian S. Robinson and Brian Lee and Susan Shaw and Hui Gong and Christianne N. Heck and Gautam Popli and Daniel E. Couture and Adrian W. Laxton and Vasilis Z. Marmarelis and Samuel A. Deadwyler and Charles Liu and Theodore W. Berger and Robert E. Hampson and Dong Song}, doi = {10.1002/advs.71942}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {71942}, shortjournal = {Adv. Sci.}, title = {Distributed temporal coding of visual memory categories in human hippocampal neurons revealed by an interpretable decoding model (Adv. sci. 38/2025)}, volume = {12}, year = {2025}, }
• (2025). Translation of a human-based malaria-on-a-chip phenotypic disease model for in vivo applications (Adv. sci. 38/2025). ADVS, 12(38), 71917. (www)

  @article{ , archive = {J_ADVS}, author = {Michael J. Rupar and Hannah M. Hanson and Brianna L. Botlick and Narasimhan Sriram and Stephanie Rogers and Justin Zuniga and Zhanhe Liu and Steven J. Trimmer and Joseph M. Ciurca and Christopher J. Long and Christopher W. McAleer and Stephan Schmidt and Paola Favuzza and Philip Lowe and Nathalie Gobeau and James J. Hickman}, doi = {10.1002/advs.71917}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {71917}, shortjournal = {Adv. Sci.}, title = {Translation of a human-based malaria-on-a-chip phenotypic disease model for in vivo applications (Adv. sci. 38/2025)}, volume = {12}, year = {2025}, }
• (2025). Bioactive silk Sericin/Bioceramic nerve guidance conduit for effective repair of long-gap transected peripheral nerve injury through regulating schwann cells (Adv. sci. 38/2025). ADVS, 12(38), 71916. (www)

  @article{ , archive = {J_ADVS}, author = {Qiangfei Su and Jian Wang and Yu Song and Zhaowenbin Zhang and Bo Cai and Xiakeerzhati Xiaohalati and Jingwei Liu and Haozhe Li and Zheng Wang and Jiang Chang and Lin Wang}, doi = {10.1002/advs.71916}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {71916}, shortjournal = {Adv. Sci.}, title = {Bioactive silk Sericin/Bioceramic nerve guidance conduit for effective repair of long-gap transected peripheral nerve injury through regulating schwann cells (Adv. sci. 38/2025)}, volume = {12}, year = {2025}, }
• (2025). Biomolecular interaction prediction: The era of AI (Adv. sci. 38/2025). ADVS, 12(38), 71915. (www)

  @article{ , archive = {J_ADVS}, author = {Haoping Wang and Xiangjie Meng and Yang Zhang}, doi = {10.1002/advs.71915}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {71915}, shortjournal = {Adv. Sci.}, title = {Biomolecular interaction prediction: The era of AI (Adv. sci. 38/2025)}, volume = {12}, year = {2025}, }
• (2025). Superlong-range magnetic coupling and ferromagnetic spin freezing in mechanoluminescent semiconductor Eu:SrAl2O4 (Adv. sci. 38/2025). ADVS, 12(38), 71914. (www)

  @article{ , archive = {J_ADVS}, author = {Xu-Guang Zheng and Ichihiro Yamauchi and Tomasz Galica and Eiji Nishibori and Tatsuya Kawae and Jumpei G. Nakamura and Akihiro Koda and Chao-Nan Xu}, doi = {10.1002/advs.71914}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {71914}, shortjournal = {Adv. Sci.}, title = {Superlong-range magnetic coupling and ferromagnetic spin freezing in mechanoluminescent semiconductor Eu:SrAl2O4 (Adv. sci. 38/2025)}, volume = {12}, year = {2025}, }
• (2025). Enhanced brain-heart connectivity as a precursor of reduced state anxiety after therapeutic virtual reality immersion (Adv. sci. 38/2025). ADVS, 12(38), 71913. (www)

  @article{ , archive = {J_ADVS}, author = {Idil Sezer and Paul Moreau and Mohamad El Sayed Hussein Jomaa and Valérie Godefroy and Bénédicte Batrancourt and Richard Lévy and Anton Filipchuk}, doi = {10.1002/advs.71913}, journal = {Advanced Science}, month = {10}, number = {38}, pages = {71913}, shortjournal = {Adv. Sci.}, title = {Enhanced brain-heart connectivity as a precursor of reduced state anxiety after therapeutic virtual reality immersion (Adv. sci. 38/2025)}, volume = {12}, year = {2025}, }
• (2025). Aging and the spectral properties of brain hemodynamics. ADVS, 12(37), e17644. (www)

  @article{ , abstract = {Cerebral glucose metabolism (CMRGlc) systematically decreases with advancing age. We sought to identify correlates of decreased CMRGlc in the spectral properties of fMRI signals imaged in the task-free state. Lifespan resting-state fMRI data acquired in 455 healthy adults (ages 18–87 years) and cerebral metabolic data acquired in a separate cohort of 94 healthy adults (ages 25–45 years, 65–85 years) were analyzed. The spectral properties of the fMRI data were characterized in terms of the relative predominance of slow versus fast activity using the spectral slope (SS) measure. We found that the relative proportion of fast activity increases with advancing age (SS flattening) across most cortical regions. The regional distribution of spectral slope was topographically correlated with CMRGlc in young adults. Notably, whereas most older adults maintain a youthful pattern of SS topography, a distinct subset of older adults significantly diverged from the youthful pattern. This subset of older adults also diverged from the youthful pattern of CMRGlc metabolism. This divergent pattern was associated with T2-weighted signal changes in frontal lobe white matter, an independent marker of small vessel disease. These findings suggest that BOLD signal spectral slope flattening may represent a biomarker of age-associated neurometabolic pathology.}, archive = {J_ADVS}, author = {Ki Yun Park and Abraham Z. Snyder and Manu S. Goyal and Timothy O. Laumann and John J. Lee and Babatunde Adeyemo and Nicholas Metcalf and Andrei G. Vlassenko and Joshua S. Shimony and Eric C. Leuthardt}, doi = {10.1002/advs.202417644}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e17644}, shortjournal = {Adv. Sci.}, title = {Aging and the spectral properties of brain hemodynamics}, volume = {12}, year = {2025}, }
• (2025). Fabricating 2D MoS2 with edge sulfur vacancy defects by heavy ion bombardment shear-exfoliation for enhanced sodium storage. ADVS, 12(37), e17576. (www)

  @article{ , abstract = {Vacancy engineering is widely considered an effective approach to modulate the internal electronic structure of electrode materials, enhancing charge-transfer processes/reactions and leading to excellent energy storage properties. Nevertheless, several current techniques of vacancy engineering, such as controlled solvent thermal growth, plasma bombardment, and chemical etching, suffer from high energy inputs and uncontrollable processing kinetics. Herein, a facile and energy-efficient technique of metal ion-assisted shear exfoliation is proposed to synthesize 2D MoS 2 with edge S-vacancies as an anode for sodium ion batteries. Thanks to the implementation of this vacancy technique, few-layer MoS 2 anode with sulfur defects at the edge presents remarkable rate performance (399.91 mAh g −1 at a current density of 5 A g −1 ) and demonstrates high average capacity with exceptional stability (460.71 mAh g −1 at 1 A g −1 after 100 cycles) when utilized in sodium-ion batteries. The superior electrochemical performance of this elaborate anode can be ascribed to the enhanced electrochemical kinetics and reaction reversibility resulting from the presence of a vacancy defect architecture. This study is expected to provide an effective avenue to develop vacancy defect electrodes for advanced batteries.}, archive = {J_ADVS}, author = {Feiyan Mu and Siqi Li and Dongqi Zhang and Qing Zhang and Zhe Hu and Ye Han and Zhixin Tai and Yajie Liu}, doi = {10.1002/advs.202417576}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e17576}, shortjournal = {Adv. Sci.}, title = {Fabricating 2D MoS2 with edge sulfur vacancy defects by heavy ion bombardment shear-exfoliation for enhanced sodium storage}, volume = {12}, year = {2025}, }
• (2025). Balancing anodic stability and cathodic kinetics in practical lithium-sulfur batteries with non-fluorinated weakly solvating solvents. ADVS, 12(37), e17305. (www)

  @article{ , abstract = {The performance of lithium-sulfur (Li-S) batteries is crucially affected by the anodic stability of Li-metal and cathodic conversion kinetics of sulfur-carbon (S/C) composites. Herein, a weakly solvating electrolyte (WSE) with moderate lithium polysulfides (LiPSs) solubility, consisting of 1 M lithium bis(trifluoromethane sulfonyl) imide (LiTFSI) in non-fluorinated solvent of cyclopentyl methyl ether (CPME) and 1,3-dioxolane (DOL) additive, is employed in Li-S batteries to simultaneously achieve high anodic stability and appropriate cathodic kinetics. This WSE exhibits a good capability of suppressing LiPSs shuttling by forming an anions-dominated Li + solvation structure, effectively inducing a stable solid electrolyte interphase (SEI) to guarantee anodic stability of the Li-metal anode. Additionally, the DOL additive in the WSE aids in forming a thin organic-inorganic hybrid cathode electrolyte interphase (CEI) on the surface of S/Li 2 S particles, which maintains good conversion kinetics and suppresses dead S/Li 2 S growth in the S/C cathode. Consequently, Li-S batteries with the WSE deliver a high initial capacity (≈1208 mAh g −1 ), a high average Coulombic efficiency (≈98.6%), and a high capacity retention rate (≈82.4%) over 200 cycles. Stable cycling performance over 100 cycles is also observed in the Li-S pouch cell with the WSE even under harsh conditions.}, archive = {J_ADVS}, author = {Zhicheng Wang and Shixiao Weng and Haiyang Zhang and Liping Wang and Xu Yao and Haifeng Tu and Dan Huang and Suwan Lu and Lingwang Liu and Jiangyan Xue and Fengrui Zhang and Guan Wu and Jieyun Zheng and Qing Wang and Liquan Chen and Jingjing Xu and Hong Li and Xiaodong Wu}, doi = {10.1002/advs.202417305}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e17305}, shortjournal = {Adv. Sci.}, title = {Balancing anodic stability and cathodic kinetics in practical lithium-sulfur batteries with non-fluorinated weakly solvating solvents}, volume = {12}, year = {2025}, }
• (2025). Localized delivery of the mRNAs encoding CD47 inhibitor and interleukins 12, 15, and 21 elicits robust antitumor immunity. ADVS, 12(37), e17205. (www)

  @article{ , abstract = {CD47 inhibitors have emerged as promising candidates in cancer immunotherapy by activating macrophage phagocytosis through CD47/SIRPα signal blockade and enhancing dendritic cell antigen presentation. However, their clinical efficacy remains limited and is accompanied by severe side effects, including anemia and hemagglutination. To address these limitations, a localized delivery strategy is developed using lipid nanoparticles to encapsulate mRNA encoding a secreted CD47 inhibitor. This mRNA-derived CD47 inhibitor effectively activated macrophages against cancer cells in vitro. To improve its modest tumor-suppressive effects in vivo, a combination therapy is formulated by co-delivering mRNAs encoding the CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21), achieving synergistic antitumor effects. Notably, this strategy induces robust systemic antitumor immunity and long-lasting immunological memory, effectively suppressing metastatic tumor progression following localized treatment of the primary tumor. Mechanistically, the mRNA-derived CD47 inhibitor promoted the differentiation of conventional type 1 dendritic cells, facilitating T cell cross-priming and activating cytotoxic T cells. Additionally, the cytokine cocktail further augmented the antitumor activity of these cytotoxic T cells. These findings present a promising strategy for advancing clinical cancer treatment, addressing key challenges associated with current CD47 inhibitor therapies.}, archive = {J_ADVS}, author = {Tao Jiang and Shuaiyang Jing and Haojun Li and Bao Xiao and Jiahui Jin and Xiu Sun and Juan Wang and Jing Liang and Tongze Cai and Huili Hu and Meilan Wei and Xuanrui Zhong and Yang Ji and Peng George Wang and Jianlong Zhou}, doi = {10.1002/advs.202417205}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e17205}, shortjournal = {Adv. Sci.}, title = {Localized delivery of the mRNAs encoding CD47 inhibitor and interleukins 12, 15, and 21 elicits robust antitumor immunity}, volume = {12}, year = {2025}, }
• (2025). Engineered foxp1high exosomes ameliorates systemic lupus erythematosus. ADVS, 12(37), e15712. (www)

  @article{ , abstract = {Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and impaired Treg cell differentiation. Mesenchymal stem cell-derived exosomes (MSC-exos) hold promise for treating immune-related diseases, while their clinical application is hindered by the limited production and non-specific organ distribution. In this study, a combined engineering strategy is developed for MSC-exo via aggregation culture and genetic editing, achieving a substantial increase in both exosome yield and therapeutic specificity in SLE. First, MSCs produce a high yield of engineered exosomes through an aggregation culture engineering strategy (Agg-exo), demonstrating immune organ targeting and promoting Tregs via the Foxp1/STAT5/Foxp3 axis. Then, MSCs are engineered by overexpressing Foxp1 in order to acquire Foxp1 high Agg-exo with enhanced immunomodulatory properties, which showes superior therapeutic effect for SLE. Taken together, a newly dual-engineering strategy is developed to produce high-yield, Foxp1 high Agg-exo, which solved the limitation of low-yield production and non-specific organ distribution of MSC-exos. This innovative strategy holds great potential for the development of exosome-based therapies in autoimmune diseases.}, archive = {J_ADVS}, author = {Luhan Niu and Qianmin Ou and Qianhui Ren and Zhengshi Li and Hongcheng Chen and Fangcao Lei and Xueli Mao and Songtao Shi and Zetao Chen and Wei Teng}, doi = {10.1002/advs.202415712}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e15712}, shortjournal = {Adv. Sci.}, title = {Engineered foxp1high exosomes ameliorates systemic lupus erythematosus}, volume = {12}, year = {2025}, }
• (2025). Erratum to “RPL6 interacts with HMGCS1 to stabilize HIF-1α by promoting cholesterol production in hepatocellular carcinoma”. ADVS, 12(37), e14955. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202514955}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e14955}, shortjournal = {Adv. Sci.}, title = {Erratum to “RPL6 interacts with HMGCS1 to stabilize HIF-1α by promoting cholesterol production in hepatocellular carcinoma”}, volume = {12}, year = {2025}, }
• (2025). Dynein-dependent endo-lysosomal degradation drives lewy body disorders accompanied by aβ pathology. ADVS, 12(37), e14860. (www)

  @article{ , abstract = {Dementia with Lewy bodies (DLB) is a significant cause of dementia. However, the limited availability of animal and cellular models that accurately replicate early DLB pathogenesis hampers the understanding of how Aβ plaques influence α-synuclein (αSyn) pathologies. This study addresses this gap by co-culturing primary neurons with adult hippocampal brain slices from either wild-type or Alzheimer's disease (AD) mice containing abundant Aβ plaques and cytokines. Neurons exposed to AD slices showed impaired dynein-dependent organelle trafficking, reducing endosome–lysosome fusion and causing defective degradation of amyloidogenic αSyn fibrils, thus increasing αSyn inclusions. Notably, an abnormal pre-accumulation of dynein in AD mice suggests that dysfunctional dynein may serve as a nucleation site for αSyn aggregation upon exposure to pathogenic fibrils. Furthermore, Rab7 activation successfully restored endo-lysosomal degradation of αSyn fibrils and reduced inclusion formation in mouse models presenting with both Lewy body and Aβ pathologies. These results highlight the dynein-dependent endo-lysosomal pathway as a promising therapeutic target for mitigating αSyn-related pathologies in co-existing Aβ burden, characteristic of many DLB cases.}, archive = {J_ADVS}, author = {Linlin Zhou and Yuwei Wang and Yu Liu and Feipeng Zhu and Ge Gao and Chengjie Li and Pu Ai and Jingying Xu and Junxin Wang and Long Guo and Yuting Guan and Virginia Man-Yee Lee and Jianjun Chen and Jialin Zheng and Qihui Wu}, doi = {10.1002/advs.202414860}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e14860}, shortjournal = {Adv. Sci.}, title = {Dynein-dependent endo-lysosomal degradation drives lewy body disorders accompanied by aβ pathology}, volume = {12}, year = {2025}, }
• (2025). Hypoglycemia induces diabetic macrovascular endothelial dysfunction via endothelial cell PANoptosis, macrophage polarization, and VSMC fibrosis. ADVS, 12(37), e14530. (www)

  @article{ , abstract = {Hypoglycemia is a commonly neglected complication in elderly diabetic patients, which can lead to cardiovascular events. Endothelial cell dysfunction is the primary inducer of cardiovascular events, and it is associated with hypoglycemia-triggered cytokine release and inflammatory programmed cell death. A comprehensive understanding of lineage-specific variations in pathological vascular changes is essential to mitigate cardiovascular events and ensure therapeutic efficacy. Herein, unbiased clustering analyses and single-nucleus RNA sequencing are performed on cells of the thoracic aorta in db/db and insulin-induced hypoglycemic db/db mice. Comparative analyses show changes in lineage-specific genes, subpopulation composition, intercellular communication, and molecular biology in hypoglycemic diabetic mice. The analyses also revealed the changes of different cells, particularly endothelial cell PANoptosis, macrophage inflammatory polarization, and vascular smooth muscle cell (VSMC) fibrosis. Pseudo-time sequencing, differential expression, and regulation network analyses revealed the association of potential hub genes Klf2 , ETS2 , Elavl1 , C3 , and Nr4a1 with the mentioned pathological processes. It is demonstrated that hypoglycemia induces VSMC fibrosis in vivo, whereas Angptl4 knockdown can attenuate VSMC fibrosis in vitro. These findings demonstrate the hypoglycemic macroangiopathy mechanism and provide important references for future disease intervention and treatment.}, archive = {J_ADVS}, author = {Deyu Zuo and Yuce Peng and Guozhi Zhao and Zhesheng Cheng and Minghao Luo and Dingyi Lv and Shuting Chang and Na Li and Yanyao Huang and Xunjia Li and An He}, doi = {10.1002/advs.202414530}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e14530}, shortjournal = {Adv. Sci.}, title = {Hypoglycemia induces diabetic macrovascular endothelial dysfunction via endothelial cell PANoptosis, macrophage polarization, and VSMC fibrosis}, volume = {12}, year = {2025}, }
• (2025). Potentiating the efficacy of mRNA vaccines through NIR-II imaging-guided precise vaccination. ADVS, 12(37), e13014. (www)

  @article{ , abstract = {mRNA vaccines have been widely implemented and revolutionized the landscape of oncology and epidemiology. Potent vaccination demands precise control over injection depth to ensure optimal lymphatic drainage, driving the development of non-invasive imaging techniques to visualize the distribution and efficacy of mRNA vaccines. Herein, near-infrared-II (NIR-II) lipid nanoparticles (NIR-II-LNPs) are fabricated for mRNA delivery by integrating a cationic fluorophore amphiphile (IR780-C16) into traditional LNPs, enabling longitudinal, quantitative, and non-invasive trafficking of mRNA vaccines. The in vivo behaviors of mRNA vaccines are characterized with different vaccination protocols in mice and rabbits by NIR-II fluorescence imaging. Results proved that following a 25 µL injection of mRNA vaccines into the mouse thigh at a depth of 4 mm or a 500 µL injection volume into a rabbit at a depth of 7 mm via the intramuscular route, the vaccines rapidly and abundantly accumulated in the inguinal lymph nodes. Flow cytometry and tissue immunofluorescence analyses further validated that optimized vaccination parameters effectively activated antitumor immunity and greatly boosted the therapeutic efficacy in B16-OVA and HPV-associated mouse tumor models. NIR-II-LNPs offer a unique modality for non-invasively monitoring the fate of vaccines, reinforcing its role in preclinical and clinical mRNA therapeutics.}, archive = {J_ADVS}, author = {Mengfei Li and Xue Zheng and Xinyang Yu and Shaolong Qi and Shoujun Zhu and Guocan Yu and Songling Zhang}, doi = {10.1002/advs.202413014}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e13014}, shortjournal = {Adv. Sci.}, title = {Potentiating the efficacy of mRNA vaccines through NIR-II imaging-guided precise vaccination}, volume = {12}, year = {2025}, }
• (2025). Engineered RGD-treg-exos targeted delivery of miR-218-5p to activate mitophagy and attenuate podocyte injury in diabetic kidney disease. ADVS, 12(37), e12034. (www)

  @article{ , abstract = {Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease, and podocyte injury is an important factor in the development of DKD. Mitophagy is severely inhibited in the podocytes of patients. Damaged mitochondria aggregate in the cytoplasm and can not be removed effectively. Restoring mitophagy may be a novel strategy for the treatment of DKD. In this study, Regulatory T cells (Tregs) are found to reduce podocyte injury in DKD through exosomes. Sequencing and cross-sectional analysis revealed that exosomes from Tregs delivered miR-218-5p to increase mitophagy in podocytes by inhibiting the TNC/TLR4/SRC/FUNDC1 pathway. Treg-Exos are engineered to express RGD peptides on the membrane surface. RGD-Treg-Exos bind to integrins on the surface of podocytes and effectively target podocytes for the delivery of miR-218-5p, thus increasing mitophagy in podocytes, reducing cell apoptosis, and alleviating podocyte injury. In summary, this study revealed that engineered RGD-Treg-Exos effectively ameliorated podocyte injury in DKD, thus constituting a novel method for DKD treatment.}, archive = {J_ADVS}, author = {Zhaochen Guo and Shaohui Gao and Ziyue Wang and Zige Chen and Jinglei Chen and Aiping Duan and Feng Xu and Qinger Wang and Weisong Qin and Caihong Zeng and Zhihong Liu and Hao Bao}, doi = {10.1002/advs.202412034}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e12034}, shortjournal = {Adv. Sci.}, title = {Engineered RGD-treg-exos targeted delivery of miR-218-5p to activate mitophagy and attenuate podocyte injury in diabetic kidney disease}, volume = {12}, year = {2025}, }
• (2025). Spin-state engineering of iron phthalocyanine D-orbitals via atomic fe-n4 coupling for enhanced oxygen reduction reaction. ADVS, 12(37), e10306. (www)

  @article{ , abstract = {Since the properties of electron transfer and orbital interactions in oxygen electrocatalysts are highly spin-dependent, reaction kinetics and thermodynamics are very sensitive to the spin configuration. However, understanding the spin-related origin of catalytic activity in heterogeneous molecular electrocatalysts still remains challenging. Herein, a molecular-atomic coupled catalyst is constructed by integrating iron phthalocyanine (FePc) molecules with Fe-N 4 atomic sites anchored on nitrogen-doped carbon nanotubes (FePc-Fe-NCNT). The strong electronic coupling between FePc and the Fe-N 4 -containing carbon substrate triggers a transition of the Fe sites from a low-spin state to an intermediate-spin state. Additionally, the formation of σ* bonds between the electron-injected perpendicular d z2 orbitals of intermediate-spin Fe and the 2p orbitals of adsorbed oxygen species suppresses site blocking and accelerates OH* desorption, thereby enhancing the reaction kinetics of the oxygen reduction reaction (ORR). The resulting catalyst exhibits exceptional ORR activity in alkaline media, reaching a half-wave potential of 0.89 V and negligible degradation after 10,000 cycles. Remarkably, the quasi-solid-state Zinc-air battery based on this prepared catalyst operates stably from −40 to 70 °C with minimal performance loss. This work reveals a spin-state manipulation strategy for the development of advanced molecular catalysts and provides new insights into the regulation of electronic structure for energy conversion technologies.}, archive = {J_ADVS}, author = {Ze Lv and Zheng Shu and Yang Qiu and Jiawei Luo and Kaibing Xu and Yimeng Ma and Linping Zhang and Hong Xu and Zhiping Mao}, doi = {10.1002/advs.202510306}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e10306}, shortjournal = {Adv. Sci.}, title = {Spin-state engineering of iron phthalocyanine D-orbitals via atomic fe-n4 coupling for enhanced oxygen reduction reaction}, volume = {12}, year = {2025}, }
• (2025). In situ vaccines in the era of cancer immunotherapy: Conceptual innovation and clinical translation. ADVS, 12(37), e09836. (www)

  @article{ , abstract = {Historically, directly injecting therapeutics into tumors has been deemed suboptimal and less favorable in clinical settings compared to systemic administration due to the inability to eradicate circulating/metastatic tumor cells until the emergence of the concept of in situ vaccine. In situ vaccine leverages patients’ own tumors as a pool of antigens to elicit systemic antitumor immunity (also known as “abscopal effect”) that aims to eliminate both primary and distal/metastatic tumors. One typical example of an approved product is Talimogene laherparepvec, an oncolytic virus approved in 2015 for treating advanced melanoma. To improve the effectiveness and the biosafety of in situ vaccines, various approaches have emerged, including new generations of oncolytic viruses, engineered bacteria, cytokine treatment, immune adjuvants, nanotechnology-enabled formulations, and photo/radio-therapies, showing remarkable promise in preclinical and clinical settings. These conceptual advances offer tailored solutions to challenges such as low antigen availability, limited immune activation, and side effects. In this review, we explore the current landscape of in situ cancer vaccines, categorizing them based on their functional formulations and highlighting their conceptual innovation in cancer immunotherapy. Additionally, a comprehensive discussion is provided of the existing clinical trials and our perspective on future clinical translation.}, archive = {J_ADVS}, author = {Yiru Shi and Yuxuan Hou and Moustafa T. Mabrouk and Chengzhong Yu and Yannan Yang}, doi = {10.1002/advs.202509836}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09836}, shortjournal = {Adv. Sci.}, title = {In situ vaccines in the era of cancer immunotherapy: Conceptual innovation and clinical translation}, volume = {12}, year = {2025}, }
• (2025). Carbon-coated probiotics restore intestinal homeostasis to promote damage repair in inflammatory bowel disease. ADVS, 12(37), e09812. (www)

  @article{ , abstract = {Inflammatory bowel disease (IBD) is regarded as green cancer that seriously endangers human quality of life. Orally administered probiotic treatment has been regarded as a promising strategy for the adjunctive treatment of IBD. However, its efficacy is greatly inhibited due to the harsh gut microenvironment and low targeted delivery volume. Herein, carbon dots are applied to modify Lactobacillus rhamnosus GG (C dots@LGG) to enhance the anti-inflammatory and injury healing effects of probiotics. The C-dots coating bestowed probiotics with a remarkable antioxidant capability, thereby mitigating inflammation and safeguarding LGG from the rigors of gastrointestinal circumstances and oxidative harm within the inflamed colon, as well as facilitating its adhesion and colonization. Conjointly, C dots@LGG reconstructs the intestinal barrier by spurring the proliferation of intestinal epithelial cells, especially goblet cells, and enhancing the intercellular tight junction (TJ). Moreover, C dots@LGG with enhanced metabolic capacity regulated the gut microbiota by enriching its diversity, suppressing the multiplication of harmful bacteria, and fostering that of beneficial bacteria. Collectively, these combined effects endow C dots@LGG to effectively attenuate mice colitis and promote injury healing in vivo. Given its simple synthesis protocol, it is anticipated that C dots@LGG can provide an effective approach for the collaborative non-immunosuppressive therapy for IBD.}, archive = {J_ADVS}, author = {Xue Chen and Haiyan Guo and Yuhan Li and Qiaowen Lin and Hua Liu and Liwen Hong and Lei Wang and Jie Zhong and Dalong Ni and Zhengting Wang}, doi = {10.1002/advs.202509812}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09812}, shortjournal = {Adv. Sci.}, title = {Carbon-coated probiotics restore intestinal homeostasis to promote damage repair in inflammatory bowel disease}, volume = {12}, year = {2025}, }
• (2025). Repositioning antimicrobial peptides against WHO-priority fungi. ADVS, 12(37), e09567. (www)

  @article{ , abstract = {The growing threat of fungal infections, particularly in immunocompromised individuals, is exacerbated by the limited number of antifungal drug classes, increasing resistance rates, and complex hostpathogen interactions. In response to this public health concern, the World Health Organization published its first list of fungal priority pathogens, including C. auris, A. fumigatus, C. neoformans, and C. albicans. These species exhibit multidrug resistance, virulence plasticity, and enhanced biofilm-forming capacity, which contributes to antifungal tolerance and complicates treatment outcomes. Antimicrobial peptides (AMPs) have emerged as promising alternatives due to their broad-spectrum activity, rapid membrane-disrupting mechanisms, and low propensity to induce resistance. This review provides an in-depth analysis of AMP-based antifungal strategies, integrating insights from structureactivity relationships, molecular engineering, and targeted delivery systems. Strategies such as peptide hybridization, cyclization, PEGylation, and nanoparticle conjugation are examined to enhance stability, specificity, and pharmacokinetics. Opportunities for rational AMP design are also discussed, leveraging computational toolsincluding machine learning and deep learning approachesalongside immunoproteomic targeting. Together, these multidisciplinary advances underscore the potential of AMPs as next-generation therapeutics against critical fungal pathogens. Nonetheless, clinical translation remains challenging, requiring continued investment in formulation science, regulatory alignment, and translational development pipelines.}, archive = {J_ADVS}, author = {Cesar Augusto Roque-Borda and Kaila Petronila Medina-Alarcón and João Paulo Soler Gonçalves Pereira and Thais Cristina dos Anjos Sevilhano and Brigitte Aguilar-Morón and Fernando Díaz-Cárdenas and Lucas Silva da Cruz and Francisco Humberto Xavier-Júnior and Eduardo Festozo Vicente and João Perdigão and Beatriz G. de la Torre and Fernando Albericio and Fernando Rogério Pavan}, doi = {10.1002/advs.202509567}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09567}, shortjournal = {Adv. Sci.}, title = {Repositioning antimicrobial peptides against WHO-priority fungi}, volume = {12}, year = {2025}, }
• (2025). From charge storage rulebook rewriting to commercial viability of zinc-manganese batteries. ADVS, 12(37), e09520. (www)

  @article{ , abstract = {Aqueous zinc-manganese oxide (Zn-MNO) batteries represent a compelling solution for grid-scale energy storage due to their inherent safety, cost-effectiveness and ecological compatibility. However, the commercialization of this technology faces critical challenges including insufficient electrode durability, limited areal capacity output, and fundamentally ambiguous charge storage principles, which collectively hinder practical implementation. Through systematic mechanistic investigation, a previously overlooked phase evolution paradigm is revealed. It involves that Mn 3 O 4 cathode undergoes a partially in situ phase transition to MnO 2 during the initial charging process, forming a hybrid Mn 3 O 4 /MnO 2 cathode. This self-optimized heterostructure synergistically combines structural reinforcement frameworks with enhanced ion-transport networks, enabling exceptional cycling stability over 4,500 cycles while maintaining record-high areal capacity (10 mAh cm −2 ). The clarified dual-ion (H + /Zn 2+ ) coordination mechanism and stabilized Mn 2+ /MnO 2 redox chemistry establish new design principles for manganese-based cathodes. More importantly, unprecedented scalability is demonstrated through constructing pouch cells (200 mAh) with 1000-cycle durability, achieving a practical energy density of 54 Wh kg −1 . The integrated solar-powered battery system exhibits remarkable operational safety under extreme conditions (piercing, cutting), representing one of the most practically viable Zn-MNO batteries reported to date. This work bridges fundamental mechanistic understanding with industrial-grade device engineering, charting a concrete pathway toward terawatt-hour scale renewable energy storage.}, archive = {J_ADVS}, author = {Xinhua Zheng and Bibo Han and Shikai Liu and Shiya Huang and Song Wu and Mingyan Chuai and Faxing Wang and Yuping Wu}, doi = {10.1002/advs.202509520}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09520}, shortjournal = {Adv. Sci.}, title = {From charge storage rulebook rewriting to commercial viability of zinc-manganese batteries}, volume = {12}, year = {2025}, }
• (2025). Ion-pair interactions in polyphenylene-based quaternized membranes designed for phosphoric acid-doped proton exchange membranes for high-temperature fuel cells. ADVS, 12(37), e09467. (www)

  @article{ , abstract = {Phosphoric acid (PA)-doped proton exchange membranes (PEMs) face significant challenges owing to the loss of PA, particularly under high humidity conditions. Ion-pair interactions between PA and quaternary ammonium (QA) groups can effectively mitigate PA loss. Herein, polyphenylene-based quaternized membranes (BAF-QAF and C7-QAF) comprising distinct hydrophobic moieties [BAF = (perfluoropropane-2,2-diyl)dibenzene and C7 = 1,1-diphenylcycloheptane] and fluorenyl groups with pendant QA head groups are designed and used as PA-doped PEMs with low or no fluorine contents to realize high-temperature and low-humidity operability. The resulting membranes exhibited excellent PA retention, maintaining >85% of their initial proton conductivities at 90% relative humidity after 10 humidity cycles. PA-doped membranes PA-C7-QAF and PA-BAF-QAF exhibit superior proton conductivities of 60.3 and 58.4 mS cm −1 at 160 °C, respectively. PA-C7-QAF and PA-BAF-QAF fuel cells deliver peak power densities of 0.579 and 0.537 W cm −2 at 140 °C and 0.706 and 0.640 W cm −2 at 160 °C, respectively, under dehumidified conditions. The PA-C7-QAF cell also exhibits impressive durability with an average voltage decay of 30 µV h −1 (140 °C, 0.15 A cm −2 ) after an initial voltage drop. These findings underscore PA-C7-QAF and PA-BAF-QAF membranes as promising components in high-temperature fuel cells.}, archive = {J_ADVS}, author = {Lin Guo and Kenji Miyatake and Ahmed Mohamed Ahmed Mahmoud and Fanghua Liu and Fang Xian and Vikrant Yadav and Xiaofeng Hao and Shuanjin Wang and Yuezhong Meng}, doi = {10.1002/advs.202509467}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09467}, shortjournal = {Adv. Sci.}, title = {Ion-pair interactions in polyphenylene-based quaternized membranes designed for phosphoric acid-doped proton exchange membranes for high-temperature fuel cells}, volume = {12}, year = {2025}, }
• (2025). Structural basis of GABAB receptor activation during evolution. ADVS, 12(37), e09440. (www)

  @article{ , abstract = {GABA B receptor is a Class C G protein-coupled receptor (GPCR) for γ-aminobutyric acid (GABA), the principal inhibitory neurotransmitter. It forms an obligatory heterodimer consisting of two subunits, GB1 and GB2. Whether the activation mechanism of the GABA B receptor is conserved during evolution remains unknown. Here, the cryogenic electron microscopy (cryo-EM) structures of the drosophila GABA B receptor in both antagonist-bound inactive state and GABA-bound active state in complex with G i protein are reported. The drosophila GABA B receptor exhibits an asymmetric activation, mirroring its human homolog. However, a larger inactive interface prevents drosophila GABA B receptor constitutive activity. Four key residues, which are not conserved in drosophila GABA B receptor, are responsible for the activity of the positive allosteric modulator in its human homolog. Whereas the intracellular loop 2 of drosophila GB2 (dGB2) is less involved, the ordered C terminus of dGB2 and its corresponding region in its human homolog are required for G protein coupling. These evolutionary variations provide a complete understanding of the activation mechanism of the GABA B receptor and new insights for future development of allosteric modulators for medication and insecticides.}, archive = {J_ADVS}, author = {Guofei Hou and Shenglan Zhang and Cangsong Shen and Suyu Ji and Binqian Zou and Chanjuan Xu and Liang Li and Dandan Shen and Jiayin Liang and Haidi Chen and Philippe Rondard and Cheng Deng and Jun He and Yan Zhang and Jianfeng Liu}, doi = {10.1002/advs.202509440}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09440}, shortjournal = {Adv. Sci.}, title = {Structural basis of GABAB receptor activation during evolution}, volume = {12}, year = {2025}, }
• (2025). Ionic double-network hydrogels for integrated electromagnetic shielding and self-powered sensing in wearable electronics. ADVS, 12(37), e09115. (www)

  @article{ , abstract = {Cardiovascular implantable electronic devices (CIEDs) face dual challenges of high-frequency electromagnetic interference and functional integration. This work reports a multifunctional material constructed via a double-network ionic hydrogel strategy, enabling the integrated realization of efficient electromagnetic shielding and self-powered physiological monitoring. An interpenetrating network skeleton is formed through physical crosslinking of sodium alginate (SA) with Ca 2 ⁺ and in situ polymerization of acrylamide (AM). By regulating the specific coordination of ions to induce directional channels and synergistically regulating salt concentration with hydration, an absorption-dominated shielding mechanism centered on ion polarization-interface relaxation is established. The optimized h -CA-PAM-Li⁺-1.0 hydrogel exhibits an electromagnetic interference (EMI) shielding effectiveness (SE T ) of 63.75 dB in the X-band, with absorption loss accounting for over 93%. Leveraging the excellent ionic conductivity of the hydrogel, a self-powered sensor encapsulated in PDMS films and integrated with wireless modules is fabricated, capable of real-time capture of physiological signals such as heartbeat while maintaining high sensitivity and anti-interference capability in dynamic environments. Free of traditional conductive fillers, this material combines biocompatibility, low cost, and designability, providing a material-device-system integrated solution for electromagnetic protection and intelligent monitoring of implantable electronic devices and opening a new research paradigm for multifunctional shielding materials.}, archive = {J_ADVS}, author = {Chenchen Wang and Yao Ding and Tianzhao Wu and Zihua Li and Chuanshuang Hu and Zhuoqun Wang and Yonghui Zhou and Xiuyi Lin and Weiwei Zhang and Jiangtao Xu}, doi = {10.1002/advs.202509115}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09115}, shortjournal = {Adv. Sci.}, title = {Ionic double-network hydrogels for integrated electromagnetic shielding and self-powered sensing in wearable electronics}, volume = {12}, year = {2025}, }
• (2025). Synergistic photomagnetic and photomechanical dynamics in a dysprosium-based smart molecule. ADVS, 12(37), e09088. (www)

  @article{ , abstract = {Converging photomagnetic switching and photomechanical functionalities in molecular materials is critical for next-generation adaptive technologies, yet challenged by competing demands for rigid coordination environments to suppress quantum tunneling in single-molecule magnets (SMMs) and flexible frameworks to enable macroscopic motion. Herein, photoactive 9-anthracenecarboxylic acid (HAC) is integrated into a binuclear dysprosium(III) complex, ( 1 ), which simultaneously exhibits dual light-responsive behaviors of both SMMs and macroscopic mechanical motion. The 365 nm light irradiation induces [4+4] photocycloaddition of anthracene units in 1 , driving a single-crystal-to-single-crystal transformation to a 1D coordination polymer [Dy₂(HAC)₂(DMF)₂(AC)₆]n ( 1A ). This structural reorganization boosts axial magnetic anisotropy, unlocking SMM behavior with a butterfly-shaped hysteresis loop, whereas thermal annealing regenerates the pristine structure and quenches magnetic bistability. Notably, anisotropic lattice strain from cycloaddition induces macroscopic photomechanical motions, triggering macroscopic torsional dynamics in bulk crystals and pronounced flexural deformations in thin film architectures. This work pioneers the synergistic modulation of magnetic and mechanical properties through light-driven structural dynamics in a single-component system, establishing a fundamental platform for developing intelligent materials with integrated opto-magneto-mechanical functionalities for adaptive sensing and actuation technologies.}, archive = {J_ADVS}, author = {Yu-Han Wang and Shi-Kun Yan and Shuai Liang and Yan-Rui Zhao and Jin Zhang and Guo-Ming Wang and Ji-Xiang Hu}, doi = {10.1002/advs.202509088}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09088}, shortjournal = {Adv. Sci.}, title = {Synergistic photomagnetic and photomechanical dynamics in a dysprosium-based smart molecule}, volume = {12}, year = {2025}, }
• (2025). Artificial internalizing receptors for targeted degradation of extracellular proteins. ADVS, 12(37), e09083. (www)

  @article{ , abstract = {Artificial internalizing receptors are developed, and it is demonstrated that these small organic molecules are powerful agents for capturing and removing the cognate protein of interest from the extracellular space. Toward the overall goal, a range of candidate receptor molecules is synthesized, and the leads are selected based on the highest efficacy of protein capture and internalization by the receptor-engineered cells. Receptor performance is validated in model T lymphoblasts, donor-derived peripheral blood mononuclear cells, and hepatocytes. The capture and depletion are achieved over successive additions of the extracellular target protein.  In contrast to pan-IgG degraders, artificial receptors depleted the one, cognate immunoglobulin, leaving the pool of non-cognate proteins un-altered. In an in vitro model system, mimicking hepatic removal of the target protein, receptor-engineered scavenger hepatocytes captured the protein of interest and prevented its association with the cognate receptor on the responder lymphoblasts.}, archive = {J_ADVS}, author = {Ane B. Søgaard and Rikke Fabech Hansson and Mikkel Høj Nielsen and Alexander N. Zelikin}, doi = {10.1002/advs.202509083}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09083}, shortjournal = {Adv. Sci.}, title = {Artificial internalizing receptors for targeted degradation of extracellular proteins}, volume = {12}, year = {2025}, }
• (2025). Heterointerface-engineered SiC@SiO2@C nanofibers for simultaneous microwave absorption and corrosion resistance. ADVS, 12(37), e09071. (www)

  @article{ , abstract = {To meet the demands of maritime defense and transportation, next-generation microwave absorption (MA) materials must combine efficient attenuation and corrosion resistance (CR). SiC nanofibers, with their moderate dielectric constant and chemical inertness, are ideal multifunctional coating fillers. However, their single-component nature limits microwave attenuation, resulting in low efficiency and narrow bandwidth. Incorporating corrosion-resistant components and employing heterointerface engineering offers a promising strategy to enhance polarization loss and synergistically improve CR. In this study, SiC nanofibers synthesized via chemical vapor deposition are used as precursors; SiO 2 interlayers and nitrogen-doped carbon shells are sequentially introduced to form multilayered core–shell nanofibers. Abundant heterointerfaces and defects effectively regulate impedance matching and introduce multiple loss mechanisms, including conduction, interfacial, and defect-induced dipole polarization. The prepared SiC@SiO 2 @C (SSC) nanofibers achieve a minimum reflection loss of −52.40 dB, a maximum effective absorption bandwidth of 7.68 GHz, and a maximum radar cross-section reduction of 38.42 dB m 2 , demonstrating excellent MA properties. Moreover, SSC/polyvinylidene fluoride (PVDF) composite coatings exhibit superior CR performance, with significantly enhanced corrosion potential and reduced current density compared to pure metal and PVDF coatings. This study underscores the synergistic effect of heterointerface engineering in enhancing both MA and CR for harsh environments.}, archive = {J_ADVS}, author = {Limeng Song and Feiyue Hu and Yongqiang Chen and Li Guan and Peigen Zhang and Linan Wang and ZhengMing Sun and Yanqiu Zhu and Hailong Wang and Renchao Che and Bingbing Fan and Rui Zhang}, doi = {10.1002/advs.202509071}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09071}, shortjournal = {Adv. Sci.}, title = {Heterointerface-engineered SiC@SiO2@C nanofibers for simultaneous microwave absorption and corrosion resistance}, volume = {12}, year = {2025}, }
• (2025). Polarization-improved bidirectional-pump atomic magnetometer based on spin-decoupled metasurface. ADVS, 12(37), e09028. (www)

  @article{ , abstract = {The optically pumped atomic magnetometer (OPAM) has emerged as an advanced instrument for magnetic field detection. However, the performance of conventional OPAMs is constrained by factors such as non-uniform atomic polarization and insufficient precision in system polarization control. In this study, a bidirectional-pump OPAM based on spin-decoupled metasurface is presented and experimentally demonstrated. By designing a metasurface structure with a predefined phase distribution, the system generates two circularly polarized (CP) lights with distinct chirality and one linearly polarized (LP) light. Two beams of the CP light are directed in opposite directions along both sides of the cell, which effectively mitigates the polarization gradient within the cell and enhances the stability of the system. Additionally, the use of zero-order LP light as the probe light for the system enhances energy utilization efficiency while simplifying the system architecture. The experimental results demonstrate that the OPAM based on metasurface successfully realizes precise control of atomic spin polarization. The proposed OPAM is capable of performing high-precision magnetic field measurements, and the sensitivity has been improved to 1.85 pT/Hz 1/2 . This research not only advances the application of metasurfaces in quantum precision measurement but also offers a novel approach for enhancing the performance of atomic magnetometers.}, archive = {J_ADVS}, author = {Shuo Sun and Jiahao Zhang and Rongtong Zhu and Huanyu Zhou and Tianshi Cheng and Liang Chen and Jin Li}, doi = {10.1002/advs.202509028}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09028}, shortjournal = {Adv. Sci.}, title = {Polarization-improved bidirectional-pump atomic magnetometer based on spin-decoupled metasurface}, volume = {12}, year = {2025}, }
• (2025). Direct observation of suppressed Optical–Acoustic phonon energy coupling in supported SWCNT at cryogenic temperatures. ADVS, 12(37), e09005. (www)

  @article{ , abstract = {Nonequilibrium among phonon branches critically influences nanoscale heat transport yet remains largely unexplored in one-dimensional (1D) systems, particularly at cryogenic temperatures. This work reports the first experimental quantification of optical–acoustic phonon coupling factor ( G OA ) in single-walled carbon nanotubes using the frequency-domain energy transport state-resolved Raman technique at cryogenic and room temperatures. Remarkably, a strong suppression of G OA is observed at low temperatures that exceeds the suppression of the coupling of interfacial phonon modes. As temperature increases, G OA is found to increase monotonically, consistent with enhanced anharmonic decay processes of optical phonons. At 93 K, the optical–acoustic phonon temperature difference exceeds 75% of the acoustic phonon temperature rise, which is reduced to about 33% at room temperature. The critical role of laser heating size on phonon nonequilibrium is elucidated, where it gets amplified for a more confined heating size. By utilizing the recently developed equivalent interfacial medium model, the intrinsic temperature-dependent interfacial thermal conductance based on acoustic phonon temperature is obtained. The results show that neglecting the nonequilibrium among phonon branches overestimates the interfacial conductance by ≈30% at room temperature. This research provides fundamental insights into phonon nonequilibrium in 1D nanoscale materials that strongly impact next-generation nanoelectronics and solid-state energy converters.}, archive = {J_ADVS}, author = {Ibrahim Al Keyyam and Yu Hua and Baini Li and Tianyu Wang and Cheng Deng and Xinwei Wang}, doi = {10.1002/advs.202509005}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e09005}, shortjournal = {Adv. Sci.}, title = {Direct observation of suppressed Optical–Acoustic phonon energy coupling in supported SWCNT at cryogenic temperatures}, volume = {12}, year = {2025}, }
• (2025). Luminescent platform for thermal sensing and imaging based on structural phase-transition. ADVS, 12(37), e08920. (www)

  @article{ , abstract = {The luminescent properties of Eu 3+ ions are highly sensitive to changes in their local crystal environment. While this feature has been widely studied, its application in thermometers based on thermally induced structural phase transitions is a recent development. These thermometers often suffer from a narrow thermal operating range, prompting the search for new host materials. In this context, Na 3 Sc 2 (PO 4 ) 3 :Eu 3+ as a function of temperature and dopant ion concentration. As demonstrated, Na 3 Sc 2 (PO 4 ) 3 :Eu 3+ was investigated as a potential candidate. This material undergoes a reversible phase transition from a monoclinic to a trigonal structure, leading to significant changes in both the emission spectra and the luminescence decay of Eu 3+ ions. These effects enable the development of both ratiometric and lifetime-based luminescent thermometers, achieving maximum relative sensitivities of 3.4% K −1 and 1.0% K − 1, respectively. Furthermore, the thermal operating range can be tuned by adjusting the Eu 3+ concentration. Importantly, this study demonstrates, for the first time, temperature imaging using only Eu 3+ -doped phosphor via a digital camera without the use of optical filters. These results position Na 3 Sc 2 (PO 4 ) 3 :Eu 3+ as a promising multifunctional material for advanced applications in contactless temperature sensing and thermal imaging.}, archive = {J_ADVS}, author = {Anam Javaid and Maja Szymczak and Malgorzata Kubicka and Vasyl Kinzhybalo and Marek Drozd and Damian Szymanski and Lukasz Marciniak}, doi = {10.1002/advs.202508920}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e08920}, shortjournal = {Adv. Sci.}, title = {Luminescent platform for thermal sensing and imaging based on structural phase-transition}, volume = {12}, year = {2025}, }
• (2025). Comparative single-cell transcriptomic landscape reveals the regulatory mechanisms of lactation during selective breeding in asian water buffalo. ADVS, 12(37), e08847. (www)

  @article{ , abstract = {Characterizing the cell type-specific transcriptome is crucial for understanding the cellular and molecular regulatory mechanisms underlying adaptive evolution and complex phenotypes. Here, single-cell/nucleus RNA sequencing (sc/snRNA-seq) is used to construct a cell transcriptomic atlas of 397,011 cells, representing 57 cell types, from 12 tissues in river and swamp buffalo, which exhibit significant divergence in milk production. Differential expression analyses identify metabolic and secretory tissues (i.e., liver, mammary gland, and pituitary) and cell types (e.g., hepatocytes, luminal cells, somatotropes, and lactotropes) that mediate the divergence of milk production. Lactotrope-specific downregulation of TRHDE in river buffalo is associated with high milk production. Integrative analyses of sc/snRNA-seq data with genomic data in buffalo and cattle reveal key cell types (e.g., luminal cells and excitatory neurons) and genes (e.g., RPL13 and LALBA ) associated with milk production. Ultimately, the Buffalo Cell Atlas (http://bovomicshub.com) will serve as a valuable resource for advancing buffalo genetics and genomics research, enabling cross-species comparative transcriptome studies and providing deeper insights into the regulation of milk synthesis and secretion.}, archive = {J_ADVS}, author = {Dongmei Dai and Jingfang Si and Li Jiang and Bo Han and Kailai Wang and Xue Wang and Shihui Yan and Yichang Yin and Wei Chen and Huaming Mao and Alfredo Pauciullo and Shang-Tong Li and Lingzhao Fang and Yi Zhang}, doi = {10.1002/advs.202508847}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e08847}, shortjournal = {Adv. Sci.}, title = {Comparative single-cell transcriptomic landscape reveals the regulatory mechanisms of lactation during selective breeding in asian water buffalo}, volume = {12}, year = {2025}, }
• (2025). Inhibition of FOXM1 synergizes with BH3 mimetics venetoclax and sonrotoclax in killing multiple myeloma cells through repressing MYC pathway. ADVS, 12(37), e08822. (www)

  @article{ , abstract = {Relapsed and refractory multiple myeloma (RRMM) remains the leading cause of MM mortality. FOXM1 is strongly associated with RRMM, making it a compelling therapeutic target. Through three low-throughput screenings, we have identified nine FDA-approved drugs, including the BH3 mimetic Venetoclax, that synergize with FOXM1 inhibitor NB73 in killing MM cells. Venetoclax has shown effects in 6% of non-t(11;14) and 27% of t(11;14) MM cases. The NB73-Venetoclax combination barely induces acute toxicity in vivo and represses MM cells in vivo and ex vivo. NB73 enhances the ubiquitination and proteasomal degradation of FOXM1, an effect further amplified by Venetoclax. The NB73-Venetoclax combination abolishes FOXM1's binding to promoters of key MYC pathway genes, such as PLK1, leading to significant downregulation of their expression. Furthermore, the PLK1-specific inhibitor GSK461364 synergizes with NB73 to inhibit MM cell growth. Interestingly, NB73 does not sensitize U266 cells, a Venetoclax-resistant t(11;14) MM cell line expressing high FOXM1, to Venetoclax treatment, which is corrected by a new-generation BH3 mimetic Sonrotoclax and ALK inhibitor Ceritinib. Collectively, targeting FOXM1 demonstrates significant potential for enhancing the efficacy of FDA-approved drugs in RRMM. These findings shed new light on the discouraging outcomes of the Phase-III CANOVA study centering Venetoclax with an encouraging molecular clue.}, archive = {J_ADVS}, author = {Zhi Wen and Yidan Wang and Kathryn C. Fox and Adam M. Bissonnette and Luke F. Moat and Terrie E. Kitchner and Kelsey Springstroh and Sung Hoon Kim and Dagna S. Sheerar and Patcharon Tanawattanacharoen and Chady A. Leon and Seth O. Fagbemi and John A. Katzenellenbogen and Scott J. Hebbring and Benita S. Katzenellenbogen and Siegfried Janz and Adedayo A. Onitilo}, doi = {10.1002/advs.202508822}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e08822}, shortjournal = {Adv. Sci.}, title = {Inhibition of FOXM1 synergizes with BH3 mimetics venetoclax and sonrotoclax in killing multiple myeloma cells through repressing MYC pathway}, volume = {12}, year = {2025}, }
• (2025). Large depth-of-field, large eyebox, and wide field-of-view freeform-holographic augmented reality near-eye display. ADVS, 12(37), e08773. (www)

  @article{ , abstract = {Augmented reality (AR) presents virtual information seamlessly integrated with real-world scenes, advancing information interaction for human society. Traditional AR displays struggle to simultaneously achieve large depth-of-field (DOF), large viewing eyebox, and wide field-of-view (FOV), which limits their practical applicability. Here, a novel AR near-eye display scheme is proposed that addresses these limitations, providing a large DOF, expansive eyebox, and wide FOV. The DOF is largely extended at each viewpoint on the eye pupil plane by directly projecting light rays onto the retina. Meanwhile, numerous viewpoints are generated in space to significantly expand the viewing eyebox, with each viewpoint independently controllable to dynamically track eye movements in real time without the need for mechanical steering parts. Freeform and holographic optics are deeply cooperated in the proposed off-axis display for achieving high performance over the full FOV, eyebox and DOF range, as well as compact form factor. A display system prototype is built, and the display results, featuring a DOF from 0.25 to 10 m, a 50° wide FOV, and a 10 mm×10 mm viewing eyebox, along with good optical see-through viewing, demonstrate the effectiveness and advancement of the proposed scheme, offering valuable insights for the future design of AR displays.}, archive = {J_ADVS}, author = {Yongdong Wang and Tong Yang and Xin Lyu and Dewen Cheng and Yongtian Wang}, doi = {10.1002/advs.202508773}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e08773}, shortjournal = {Adv. Sci.}, title = {Large depth-of-field, large eyebox, and wide field-of-view freeform-holographic augmented reality near-eye display}, volume = {12}, year = {2025}, }
• (2025). Unique color display via high-order reflectance in 1D photonic crystals for advanced security levels in anti-counterfeiting applications. ADVS, 12(37), e08682. (www)

  @article{ , abstract = {Herein, humidity-responsive 1D photonic crystal (PC) films are developed that are capable of generating higher-order photonic stop bands (PSBs). As a critical factor for achieving 2 nd - and 3 rd -order PSBs, the layer thickness is modulated to achieve multi-wavelength reflectivity within a single film. The films are fabricated using alternating layer deposition of photo-crosslinkable poly(2-vinylnaphthalene- co -benzophenone acrylate) (p(2VN- co -BPA)) and 52%-quaternized poly(4-vinylpyridine- co -benzophenone acrylate) (P4QP-52%). Upon increasing the relative humidity (RH), the films exhibit 1 st -, 2 nd -, and 3 rd -order PSBs with visible color transitions across the spectrum. This behavior becomes evident as the thickness of the P4QP-52% layer increases. Notably, for those films with relatively thick P4QP-52% layers, the shift in the 2 nd - and 3 rd -order PSBs is substantial enough to create composite colors, such as magenta, through the superposition of red from the 2 nd -order PSB and blue from the 3 rd -order PSB. This mechanism represents a significant advancement in PC technology and opens up new possibilities for colorimetric sensing and tunable optical materials. For practical applications, these films are further explored in anti-counterfeiting applications, where their color transitions and hidden patterning are demonstrated. The films showed vivid color changes and distinct patterning in response to high humidity, offering potential for use in security and authentication applications.}, archive = {J_ADVS}, author = {Jae Min Bak and Yejin Kim and Min-woo Yeo and Seo-Hyun Jung and Hyung-il Lee}, doi = {10.1002/advs.202508682}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e08682}, shortjournal = {Adv. Sci.}, title = {Unique color display via high-order reflectance in 1D photonic crystals for advanced security levels in anti-counterfeiting applications}, volume = {12}, year = {2025}, }
• (2025). Tolerant molecular engineering for high-rate and ultra-long cycle life zinc anode. ADVS, 12(37), e08628. (www)

  @article{ , abstract = {Aqueous zinc ion batteries have emerged as a promising technology for grid-scale energy storage due to their low cost and high safety. However, dendrites and side reactions at the zinc anode severely deteriorate their cycle stability. Herein, to mitigate these issues, a molecular tolerance mechanism, inspired by cell membranes in extreme plants, is employed to engineer the zinc anode surface. The molecular layer enhances both the desolvation process and transport rate of zinc ions, thereby suppressing the dendrite formation. The interfacial side reactions caused by excessive water molecules in solvated ions are practically minimized as well, thus the zinc anode turns more durable and robust under high-rate conditions. Specifically, at a moderate current density of 1 mA cm −2 @1 mAh cm −2 , the cycle stability of the zinc anode is improved to 8800 h, and up to 1100 h at a high current density of 10 mA cm −2 @5 mAh cm −2 . This work offers valuable insights into interfacial design for developing zinc ion batteries with long cycle life and fast-charging capabilities.}, archive = {J_ADVS}, author = {Chenyang Zhao and Zeping Liu and Yu Zhang and Pengyu Wang and Man Qi and Zhikun Guo and Zeen Wu and Xin Zhang and Xingyuan Lu and Jiayin Yuan and Naiqing Zhang}, doi = {10.1002/advs.202508628}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e08628}, shortjournal = {Adv. Sci.}, title = {Tolerant molecular engineering for high-rate and ultra-long cycle life zinc anode}, volume = {12}, year = {2025}, }
• (2025). Neural topology optimization via active learning for efficient channel design in turbulent mass transfer. ADVS, 12(37), e08386. (www)

  @article{ , abstract = {The design of fluid channel structures of reactors or separators of chemical processes is a key to enhancing the mass transfer processes inside the devices. However, systematically designing channel topological structures remains challenging for complex turbulent flows. Here, this challenge is addressed by developing a machine learning framework to efficiently perform topology optimization of channel structures for turbulent mass transfer. A topological structure is represented using a neural network (referred to as “neural topology”), which is optimized by employing pre-trained neural operators combined with a fine-tuning strategy with active data augmentation. The optimization is performed targeting two objectives: maximization of mass transfer efficiency and minimization of energy consumption, for the possible considerations of compromise between the two in real-world designs. The developed neural operator with active learning is data efficient in network training and demonstrates superior computational efficiency compared with traditional methods in obtaining optimal structures across a large design space. The optimization results are experimentally validated, proving that the optimized channel improves concentration uniformity by 37% compared to the original channel. The variation of the optimal structures with changes in inlet velocity conditions is also demonstrated, offering insights for designing turbulent mass transfer devices under various operating conditions.}, archive = {J_ADVS}, author = {Chenhui Kou and Yuhui Yin and Min Zhu and Shengkun Jia and Yiqing Luo and Xigang Yuan and Lu Lu}, doi = {10.1002/advs.202508386}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e08386}, shortjournal = {Adv. Sci.}, title = {Neural topology optimization via active learning for efficient channel design in turbulent mass transfer}, volume = {12}, year = {2025}, }
• (2025). One-size-fits-all: A universal binding site for single-layer metal cluster self-assembly. ADVS, 12(37), e08034. (www)

  @article{ , abstract = {2D metal clusters maximize atom–surface interactions, making them highly attractive for energy and electronic technologies. However, their fabrication remains extremely challenging because they are thermodynamically unstable. Current methods are limited to element-specific binding sites or confinement of metals between layers, with no universal strategy achieved to date. Here, a general approach is presented that uses vacancy defects as universal binding sites to fabricate single-layer metal clusters (SLMC). It is demonstrated that the density of these vacancies governs metal atom diffusion and bonding to the surface, overriding the metal's physicochemical properties. Crucially, the reactivity of vacancy sites must be preserved prior to metal deposition to enable SLMC formation. This strategy is demonstrated across 21 elements and their mixtures, yielding SLMC with areal densities up to 4.3 atoms∙nm⁻ 2 , without heteroatom doping, while maintaining high thermal, environmental, and electrochemical stability. These findings provide a universal strategy for stabilizing SLMC, eliminating the need for element-specific synthesis and metal confinement protocols and offering a strategy for efficiently utilizing metals.}, archive = {J_ADVS}, author = {Emerson C. Kohlrausch and Sadegh Ghaderzadeh and Gazi N. Aliev and Ilya Popov and Fatmah Saad and Eman Alharbi and Quentin M. Ramasse and Graham A. Rance and Mohsen Danaie and Madasamy Thangamuthu and Mathew Young and Richard Plummer and David J. Morgan and Wolfgang Theis and Elena Besley and Andrei N. Khlobystov and Jesum Alves Fernandes}, doi = {10.1002/advs.202508034}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e08034}, shortjournal = {Adv. Sci.}, title = {One-size-fits-all: A universal binding site for single-layer metal cluster self-assembly}, volume = {12}, year = {2025}, }
• (2025). Cancer cell-derived large extracellular vesicles promote venous thromboembolism by activating NETosis through delivering CYBA. ADVS, 12(37), e07867. (www)

  @article{ , abstract = {Venous thromboembolism (VTE) is the second-leading cause of cancer-associated mortality. Neutrophil extracellular trap formation (i.e., NETosis) is a crucial process in forming VTE in cancer patients. Nevertheless, how cancer cells contribute to NETosis remains unclear. This study investigated the potential activation effects of cancer cell-derived extracellular vesicles (CC-EVs) on neutrophils. Both small and large EVs (sEVs and lEVs) released from cancer cells are found to significantly induce NETosis in neutrophil-like HL-60 (dHL-60) cells. Following an in-depth exploration of EV-induced NETosis, the specific molecular pathways involved in this biological process are elucidated. CYBA enriched in CC-lEVs is delivered to dHL-60, leading to a rapid increase in intracellular ROS levels and upregulation of citH3 expression. This cascade resulted in decondensed chromatin release and subsequent NETosis along with elevated MPO-DNA levels. Injection of CC-lEVs into mice caused more pronounced VTE, which is accompanied by increased peripheral blood levels of the MPO-DNA and thrombin-antithrombin complex. Inhibiting CYBA expression or ROS generation prevented NETosis in vitro and significantly reduced VTE in vivo. In conclusion, CC-lEVs induce NETosis through the CYBA-ROS-citH3 pathway and increase VTE risk. Targeting CYBA expression or ROS production can provide novel strategies for preventing and treating VTE in high-risk cancer patients.}, archive = {J_ADVS}, author = {Xiangji Li and Yingjiao Ju and Chenjie Xu and Shixiang Ma and Lan Sun and Qingdong Guo and Mingyuan Liu and Yibin Xie and Li Min}, doi = {10.1002/advs.202507867}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07867}, shortjournal = {Adv. Sci.}, title = {Cancer cell-derived large extracellular vesicles promote venous thromboembolism by activating NETosis through delivering CYBA}, volume = {12}, year = {2025}, }
• (2025). Mussel-inspired self-assembly of PtO4 atomic catalysts for interfacial synergistic hydrogen evolution. ADVS, 12(37), e07807. (www)

  @article{ , abstract = {Molecular self-assembly strategy for Pt-O electrocatalysts is presented, achieved by facile solution processing of dopamine monomers. This mussel-inspired strategy ensures a highly defined PtO 4 atomic structure with uniform monolayer deposition across various 2D nanomaterials. By leveraging the intimate interplay between PtO 4 sites and 2D substrates, while maintaining a consistent coordination environment, underlying mechanism for enhanced kinetics in interfacial synergistic hydrogen evolution reaction is systematically elucidated. Notably, the self-assembled PtO 4 site exhibits up to a 30-fold enhancement of mass activity compared to commercial Pt/C catalysts, contingent upon the choice of substrate material. Theoretical investigation illustrates facilitated electron transfer, optimized energy barriers, and additional reaction pathways resulting from the synergistic interplay between PtO 4 and Ti 3 C 2 O 2 MXene. This straightforward, energy-efficient, and highly reliable scheme for atomic-level catalysts prospects a valuable platform toward sub-molecular level engineering of tailored electronic structures and properties.}, archive = {J_ADVS}, author = {Yeo Hoon Yoon and Karthikeyan Jeyakumar and Gang San Lee and Jayaraman Balamurugan and Suchithra Padmajan Sasikala and Chan Woo Lee and Colin Wing-Lok Cheng and Jun Beom Kim and Haeshin Lee and Sang Ouk Kim}, doi = {10.1002/advs.202507807}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07807}, shortjournal = {Adv. Sci.}, title = {Mussel-inspired self-assembly of PtO4 atomic catalysts for interfacial synergistic hydrogen evolution}, volume = {12}, year = {2025}, }
• (2025). Targeting seipin to alleviate hepatic steatosis in zebrafish (Danio rerio). ADVS, 12(37), e07777. (www)

  @article{ , abstract = {Loss of Seipin causes the absence of whole-body adipose but abnormal liver lipid deposition in patients, and liver expression of Seipin is decreased in mice fed a high-fat diet (HFD). However, the underlying mechanism of Seipin-regulated liver lipid metabolism remains mysterious. Here, experiments show that over-expression of Seipin down-regulates HFD-induced liver triglyceride (TG) accumulation and promotes zebrafish growth. Real-time PCR and immunoblotting suggest that Seipin interacts with Plin2 through its second transmembrane domain to inhibit the expression of Plin2 by promoting Plin2 ubiquitination, thereby ameliorating lipid accumulation. Co-immunoprecipitation (CoIP) experiments and Biomolecular fluorescence complementation (BiFC) analysis reveal a close interaction between Seipin and phosphatidylcholine (PC) synthesis enzyme CCTα and CHPT in zebrafish and mice. Thus, Seipin may participate in PC synthesis and increase cellular PC levels. Elevated PC levels subsequently suppress Plin2 expression. Meanwhile, CCTα, the rate-limiting enzyme of the PC synthesis pathway, exhibited a unique regulatory role on Plin2 expression as a potential transcription factor. It is proposed that Seipin balances TG homeostasis, PC synthesis, and Plin2 expression to alleviate hepatic steatosis, providing a promising target for fatty liver disease.}, archive = {J_ADVS}, author = {Weijia Li and Yanan Shen and Zengqi Zhao and Baolin Li and Shunlang Wen and Rui Zhan and Qinghui Ai}, doi = {10.1002/advs.202507777}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07777}, shortjournal = {Adv. Sci.}, title = {Targeting seipin to alleviate hepatic steatosis in zebrafish (Danio rerio)}, volume = {12}, year = {2025}, }
• (2025). Innovative design of PEI-modified AMO-layered double hydroxide for efficient and stable direct air capture of CO2. ADVS, 12(37), e07756. (www)

  @article{ , abstract = {Emerging as a critical technology for atmospheric carbon dioxide (CO 2 ) removal, the mass deployment of direct air capture (DAC) demands breakthrough innovations in efficient and stable adsorbent materials that simultaneously achieve high capacity, oxidative durability, and low cost. Herein, a hydroxyl-rich Mg 0.55 Al layered double hydroxide (LDH) support is developed via aqueous miscible organic solvent treatment, circumventing energy-intensive calcination while engineering mesopores for efficient polyethyleneimine (PEI) loading. The optimized 60 wt.% PEI modified Mg 0.55 Al-CO 3 AMO-LDH achieves a CO 2 uptake of 3.92 mmol g −1 under simulated wet air at 25 °C and retains 90.8% capacity over 20 cycles. Crucially, the abundant surface hydroxyls of uncalcined LDH, validated by 1 H Nuclear Magnetic Resonance and in situ X-ray Photoelectron Spectroscopy, form hydrogen bonds with PEI, suppressing oxidative degradation. After 3 h at 120 °C in simulated air, PEI-LDH retains a CO 2 capacity of 1.06 mmol g −1 , significantly outperforming PEI/mixed metal oxide and conventional silica-based adsorbents. In situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy further reveals that hydroxyl-mediated amine anchoring minimizes water co-adsorption. This work establishes a dual strategy of hydroxyl preservation and mesopore engineering to design cost-effective DAC adsorbents, achieving both high capacity and exceptional stability under realistic operating conditions.}, archive = {J_ADVS}, author = {Meng Zhao and Liang Huang and Yanshan Gao and Ziling Wang and Xuancan Zhu and Qiang Wang and Dermot O'Hare}, doi = {10.1002/advs.202507756}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07756}, shortjournal = {Adv. Sci.}, title = {Innovative design of PEI-modified AMO-layered double hydroxide for efficient and stable direct air capture of CO2}, volume = {12}, year = {2025}, }
• (2025). Atrial fibroblasts-derived extracellular vesicles exacerbate atrial arrhythmogenesis. ADVS, 12(37), e07627. (www)

  @article{ , abstract = {Cardiac fibroblasts (CFs) secrete exosomes, and their cargo represents a new means of cellular communication in cardiovascular diseases, including atrial fibrillation (AF). We aimed to explore the contribution of atial CFs (ACFs)-derived exosomes to AF development. Cultured primary human ACFs (hACFs) and rat ACFs are treated with angiotensin II, and the secreted exosomes are transferred to rats. Action potential duration and L-type calcium current ( I Ca ) are tested. Global microRNA-224-5p knock-in and fibroblast-specific microRNA-224-5p knock-in ( FMKI ) mice underwent an inducible AF test. Transferred exosomes of Ang II-induced hACFs and primary adult rat ACFs increased AF incidence and prolonged AF duration. The inhibitor of exosomes and knockdown of Dicer rescued the AF phenotype. MicroRNA array suggested upregulated microRNA-224-5p level in both primary adult rat ACFs and ACFs-secreted exosomes. microRNA-224-5p agonist shortened atrial effective refractory period (AERP) and promoted AF. Mechanistically, microRNA-224-5p bound to CACNA1C and inhibited its transcription. Moreover, global microRNA-224-5p knock-in and FMKI mice exhibited increased inducible AF incidence, accompanied by diminished I Ca current in ACMs. Exosome microRNA-224-5p is enhanced in ACFs isolated from atria and plasma of AF patients, and positively correlated with recurrence after radiofrequency ablation. In summary, ACFs-derived exosome microRNA-224-5p contributes to AF by inhibiting CACNA1C to drive atrial electrical remodeling.}, archive = {J_ADVS}, author = {Yue Yuan and Xinbo Zhao and Xuejie Han and Yukai Cao and Xuexin Jin and Ling Shi and Xin Bi and Desheng Li and Yun Zhang and Wenbo Ma and Jiahui Song and Zhenwei Pan and Zhiren Zhang and Yue Li}, doi = {10.1002/advs.202507627}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07627}, shortjournal = {Adv. Sci.}, title = {Atrial fibroblasts-derived extracellular vesicles exacerbate atrial arrhythmogenesis}, volume = {12}, year = {2025}, }
• (2025). Strain-sensitive thermochromic smart electronic skin for joint and spine healthcare applications. ADVS, 12(37), e07605. (www)

  @article{ , abstract = {Electronic skins (E-skins) that enable interactive and quantitative joint and spine healthcare hold transformative potential for personalized musculoskeletal rehabilitation. However, existing systems face three critical limitations: conventional strain sensors degrade with cyclic large strain due to uncontrolled crack propagation; thermal therapy lacks real-time adaptive control without feedback; and systems lack user-interactive monitoring-therapy integration. Here, iStretch, a mechano-visual-thermo adaptive e-skin is introduced that integrates durable strain sensing, dynamic heat therapy, and intuitive visual feedback via a multiphasic and bilayer architecture. The strain-sensing bottom layer utilises constrained microcrack propagation in graphene-liquid metal nanocomposites, achieving high sensitivity (GF = 281), broad sensing range (300%), and exceptional durability (10,000 cycles). Simultaneously, the thermoresponsive top layer provides dynamic visual feedback and heat modulation in response to strain. Its multifunctions are demonstrated for convolutional neural network-powered omnidirectional motion and gesture recognition, strain magnitude-adjusted thermotherapy, intuitive thermochromic overheating alerts, and quantitative cervical spine monitoring via wireless sensor arrays.}, archive = {J_ADVS}, author = {Shicheng Fan and Shuwen Chen and Zheng Qiao and Jiaming Qi and Zixiong Wu and Chwee Teck Lim}, doi = {10.1002/advs.202507605}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07605}, shortjournal = {Adv. Sci.}, title = {Strain-sensitive thermochromic smart electronic skin for joint and spine healthcare applications}, volume = {12}, year = {2025}, }
• (2025). 3D topological inorganic electrides: Screening, properties, and applications. ADVS, 12(37), e07469. (www)

  @article{ , abstract = {The convergence of inorganic electrides and topological quantum phenomena has ushered in novel paradigms for designing advanced quantum materials. While low-dimensional (0–2D) topological inorganic electrides have garnered considerable attention, their three-dimensional (3D) counterparts—featuring intricate interstitial electron networks—remain entirely uncharted territory. Herein, the identification of twelve 3D inorganic electrides within the rare-earth hydride family is reported, nine of which are previously unreported. First-principles calculations reveal a diverse magnetic landscape: two systems exhibit ferromagnetic ordering, while seven demonstrate antiferromagnetic configurations. Strikingly, these materials host rich topological states, encompassing nodal points, nodal lines, and associated surface signatures such as Fermi arcs and drumhead-like states. When spin-orbit coupling is introduced, the magnetic ordering breaks time-reversal symmetry, thereby generating substantial Berry curvature and resulting in a relatively large anomalous Hall conductivity (939 S cm −1 ). Furthermore, these inorganic electrides exhibit ultralow work functions (2.6–3.9 eV) on rare-earth-terminated surfaces. Under external electric fields, the 3D interstitial electrons migrate to the surface, forming a quasi-2D electron gas. Significantly, such low work functions can effectively activate N 2 , enhancing catalytic NH 3 synthesis. These findings establish an ideal platform to explore 3D inorganic electrides, along with their topological features, anomalous transport phenomena, low work functions, and NH 3 synthesis.}, archive = {J_ADVS}, author = {Zhenzhou Guo and Weizhen Meng and Qianwen Zhang and Xia Cheng and Shiyao Wang and Yalong Jiao and Xiaoming Zhang and Ying Liu and Tie Yang}, doi = {10.1002/advs.202507469}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07469}, shortjournal = {Adv. Sci.}, title = {3D topological inorganic electrides: Screening, properties, and applications}, volume = {12}, year = {2025}, }
• (2025). Serrodyne-enabled dual electro-optic comb interferometry for high-precision absolute ranging and integration-ready metrology. ADVS, 12(37), e07459. (www)

  @article{ , abstract = {Optical frequency combs (OFCs) have revolutionized precision metrology, enabling highly precise frequency and distance measurements. Dual electro-optic frequency comb ranging systems traditionally rely on acousto-optic modulators (AOMs) to shift the local oscillator frequency, mitigating frequency degeneracy but restricting tuning flexibility, response speed, and power efficiency. Here, an AOM-free dual electro-optic frequency comb ranging system is introduced, employing a serrodyne-modulated electro-optic modulator (EOM) for frequency shifting, achieving superior phase coherence and high-precision distance measurement. Experimental validation confirms nanometric ranging precision, with Allan deviation below 0.1 nm at 1 ms integration. The system effectively tracks high-frequency vibrations (up to 100 kHz) from a piezoelectric transducer and enables dynamic 3D surface imaging. Moreover, it detects nanoscale water surface vibrations through precise laser-ranging analysis. Notably, the system maintains high measurement precision across a wide spatial scale—from meter-level free-space ranging to nanometer-scale vibration sensing—demonstrating exceptional versatility. Compared to conventional AOM-based approaches, the method provides enhanced flexibility, reduced RF power consumption, and improved photonic integration compatibility, thus offering substantial benefits for precision metrology and high-resolution sensing applications.}, archive = {J_ADVS}, author = {Xiaoyang Guo and Xusheng Yang and Jiawen Zhi and Chenggang Shao and Hanzhong Wu}, doi = {10.1002/advs.202507459}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07459}, shortjournal = {Adv. Sci.}, title = {Serrodyne-enabled dual electro-optic comb interferometry for high-precision absolute ranging and integration-ready metrology}, volume = {12}, year = {2025}, }
• (2025). Topological insulator Bi2Te3 anode for aqueous aluminum-ion batteries: Unveiling the role of hydronium ions. ADVS, 12(37), e07255. (www)

  @article{ , abstract = {The primary scientific challenge in advancing aqueous aluminum-ion batteries (AAIBs) is achieving reversible plating/stripping of the Al metal anode, limited by its low deposition potential (−1.667 V vs SHE) and surface passivation in the aqueous electrolyte. To address this issue, polypyrrole (PPy) decorated topological quantum insulator (Bi 2 Te 3 @PPy) is introduced as a novel anode in AAIBs. Benefiting from the interconnected PPy network and the gap-free metallic surface state of Bi 2 Te 3 , the Bi 2 Te 3 @PPy anode enables a remarkable discharge capacity of 438 mAh g −1 at a current rate of 0.5 A g −1 . It also maintains a strong discharging plateau even at a higher current rate of 10 A g −1 , outperforming most electrode materials reported so far for AAIBs. The role of the topological surface states of Bi 2 Te 3 in enhancing the ion migration rate is validated by comparing its performance across various morphologies. Ex situ studies and computational analysis reveal that in aqueous systems, Al 3+ is not the sole species responsible for charge storage. Instead, hydronium ions (H 3 O + ) significantly contribute to storing the charges through intercalation into the crystal lattice. Overall, this study pioneers a new approach for developing advanced Al metal-free AAIBs and provides deeper insights into the charge storage mechanisms in aqueous electrolytes.}, archive = {J_ADVS}, author = {Puja De and Petr Lazar and Michal Otyepka and Martin Pumera}, doi = {10.1002/advs.202507255}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07255}, shortjournal = {Adv. Sci.}, title = {Topological insulator Bi2Te3 anode for aqueous aluminum-ion batteries: Unveiling the role of hydronium ions}, volume = {12}, year = {2025}, }
• (2025). Half-pipe melt electrowritten scaffolds support engineering of an immunocompetent hydrogel-embedded intestine-on-a-chip. ADVS, 12(37), e07132. (www)

  @article{ , abstract = {In vitro models that mimic intestinal mucosal tissue inflammation and assess the sensitizing capacity of food proteins are essential for understanding food allergy mechanisms and improving safety assessments. Current 2D models lack spatial epithelial-immune cell interactions, including dendritic cell (DC) migration and DC–T cell crosstalk. Intestine-on-a-chip (IoC) models are used for infections and inflammatory bowel disease (IBD) but are not yet widely used in food allergy research. Here, a 3D immunocompetent IoC model is presented using extrusion-based bioprinting and melt electrowriting (MEW). The system integrates human intestinal epithelial cells (Caco-2) seeded on half-pipe-shaped MEW scaffolds and co-cultured with hydrogel-embedded monocyte-derived DCs (moDCs) inside the printed device. Subsequent moDC–T cell interactions are studied separately in a hydrogel-embedded system. IoCs exhibited leak-tight epithelial barriers comparable to transwell-like systems, while demonstrating higher metabolic and brush border enzyme activity, and lower LDH leakage. After food allergens (peanut, milk, and egg), non-allergen (Rubisco) or pro-inflammatory stimuli (toxin A and LPS) exposure, distinguishable effects on epithelial barrier integrity and moDC driven Th1/Th2 immune responses are observed. The IoC model presents a significant step toward 3D in vitro systems that mimic the intestinal mucosa's compartments to study food allergen sensitization and inflammatory diseases.}, archive = {J_ADVS}, author = {Robine Janssen and Henrike S. Schulze and Claire M. L. Nelissen and Marta G. Valverde and Andrei Hrynevich and Govardus A. H. de Jong and Anne Metje van Genderen and Jos Malda and Shanna Bastiaan-Net and Linette E. M. Willemsen and Rosalinde Masereeuw}, doi = {10.1002/advs.202507132}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07132}, shortjournal = {Adv. Sci.}, title = {Half-pipe melt electrowritten scaffolds support engineering of an immunocompetent hydrogel-embedded intestine-on-a-chip}, volume = {12}, year = {2025}, }
• (2025). Patients-derived organoids sequencing-based FOXP4 facilitates radioresistance by transcriptionally modifying GPX4 to regulate ferroptosis in colorectal cancer. ADVS, 12(37), e07080. (www)

  @article{ , abstract = {More than 50% of patients with colorectal cancer (CRC) exhibit radioresistance, indicating the need for further research on the disease. Therefore, the aim of this study is to identify radioresistance genes and elucidate the underlying molecular mechanisms using patient-derived organoids (PDOs). Transcriptome analyses are performed on radio-resistant and -sensitive PDOs, CRC cells, and xenograft tissues to screen for radioresistant genes. Additionally, the genetic homology between PDOs and clinical tissues is verified using whole-exome sequencing. Functional experiments are performed to validate the roles of the candidate genes using cellular, organoid, and animal models. Forkhead box P4 (FOXP4) is identified as a differentially expressed genes between the radio-sensitive and -resistant groups that is linked to radioresistance. Further experiments show that FOXP4 promoted radioresistance by suppressing ferroptosis. Mechanistically, FOXP4 regulated GPX4 transcription by binding to the promoter region of GPX4 via the forkhead domain to inhibit the onset of ferroptosis. Doxorubicin (DOX) inhibited FOXP4 expression by promoting its ubiquitination and degradation, eventually increasing radiosensitivity. Notably, DOX combined with irradiation attenuated the compensatory increase in FOXP4 expression and increased radiotherapy efficacy. Conclusively, the combination therapy provides a new strategy for enhancing therapeutic efficacy in CRC.}, archive = {J_ADVS}, author = {Qianping Chen and Yuzhao Jin and Luyu Liao and Rong Shen and Xingnan Ge and Qingyu Jiang and Ying Huang and Quanquan Sun and Dong Liu and Luying Liu and Tongxin Liu and Qinghui Dai and Xiyuan Tang and Zhe Han and Xin Gao and Xinhua Lin and Wei Mao and Ji Zhu}, doi = {10.1002/advs.202507080}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07080}, shortjournal = {Adv. Sci.}, title = {Patients-derived organoids sequencing-based FOXP4 facilitates radioresistance by transcriptionally modifying GPX4 to regulate ferroptosis in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Molecular damping effect of trace additives enhances zinc anode stability under high depth of discharge. ADVS, 12(37), e07071. (www)

  @article{ , abstract = {Resolving the severe issues such as electric field distortion, dendritic zinc growth, and uneven zinc deposition under high depths of discharge (DOD) has become a significant hurdle of the aqueous zinc-ion batteries (ZIBs). To address these challenges, an interfacial regulation strategy is proposed based on the molecular damping effect, in which a trace amount of weakly adsorbing additive is employed to stabilize the Zn anode interface by mitigating energy shocks and ionic disturbances induced by electric field fluctuations. Trace perfluorinated PSVE (erfluoro-3,6-dioxa-4-methyloct-7-enesulphonyl fluoride) is introduced to the traditional ZnSO 4 electrolyte to optimize Zn deposition behavior on the zinc anode. Thus, the Zn//Zn symmetric batteries exhibit a prolonged cycling lifespan of over 200 h, even when operated at a high DOD of 85.5%. Additionally, the NVO (Na 2 V 6 O 16 ) cathodes coupled with Zn anodes and modified electrolyte present a more stable capacity retention, maintaining a capacity of 141.98 mAh g −1 after 1000 cycles. Similarly, the full batteries assembled with the same electrodes in a ZnSO 4 electrolyte retain only 51.49 mAh g −1 capacity after the same conditions. This work highlights the potential of the molecular damping effect as a promising solution for improving high DOD performance in ZIBs.}, archive = {J_ADVS}, author = {Yue Li and Hao Xu and Xiaodong Li and Xi Lin and Hongyang Zhao and Yajuan Zhang and Kwun Nam Hui and Jinliang Li and Likun Pan}, doi = {10.1002/advs.202507071}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e07071}, shortjournal = {Adv. Sci.}, title = {Molecular damping effect of trace additives enhances zinc anode stability under high depth of discharge}, volume = {12}, year = {2025}, }
• (2025). Anti-icing organogel enables quasi-homogeneous supercooling preservation of mouse hearts. ADVS, 12(37), e06968. (www)

  @article{ , abstract = {Supercooling preservation holds great promise for extending the storage limits of organs. However, supercooled systems are susceptible to stochastic ice nucleation, which can cause fatal damage to the organs. In this study, an organogel interface composed of nanoscale polydimethylsiloxane and dimethyl-silicone oil is proposed, which presents a significant energy barrier for ice nucleation, comparable to that of homogeneous nucleation. The organogel effectively eliminates primary ice nucleation sites, enabling a quasi-homogeneous supercooling preservation system that does not rely on cryoprotectant agents or machine perfusion. Through a series of statistical experiments, this approach is demonstrated to be able to maintain stable supercooling and preserve mouse hearts at −4 °C for up to 72 h. A comprehensive assessment conducted at multiple scales indicates that the 36-h supercooling preservation at −4 °C significantly mitigates cardiac injury by regulating mitochondrial structure and reducing metabolic rates. Utilizing a heart transplantation model with prognostic evaluations extending up to 3 months post-transplantation, supercooling preservation within the quasi-homogeneous system is confirmed, which can double the storage duration compared to clinically applied hypothermic preservation methods.}, archive = {J_ADVS}, author = {Junhao Li and Wei Wang and Chenghao Li and Lintao Kuang and Zhi Huang and Xing Chen and Zhenghao Guo and Kang Liu and Jinping Liu}, doi = {10.1002/advs.202506968}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06968}, shortjournal = {Adv. Sci.}, title = {Anti-icing organogel enables quasi-homogeneous supercooling preservation of mouse hearts}, volume = {12}, year = {2025}, }
• (2025). Realizing high performance in P-type SnBi2Te4 through synergistically improving effective mass and suppressing bipolar thermal conductivity. ADVS, 12(37), e06963. (www)

  @article{ , abstract = {Thermoelectric materials, which facilitate the mutual conversion between thermal and electrical energy, offer a promising alternative for sustainable energy solutions. High-performance thermoelectric materials require excellent electrical conductivity and low thermal conductivity. Among emerging candidates, AB 2 X 4 (A = Ge, Sn, Pb; B = Sb, Bi; X = Se, Te) compounds have garnered attention due to their unique septuple atomic layered crystal structure and poor lattice thermal conductivity. Here, the septuple atomic layered SnBi 2 Te 4 is successfully synthesized and its thermoelectric performance significantly enhanced through isovalent elements alloying. The peak ZT ≈ 0.56 at 473 K and an average ZT ≈ 0.47 achieved over the temperature 300–673 K, which is 12 and 14 times higher than those in pristine SnBi 2 Te 4 . The incorporation of Sb and Se into p -type SnBi 2 Te 4 system significantly improves thermoelectric performance through three synergistic mechanisms: 1) enhance the electrical conductivity via effective mass enlarging, 2) suppress the bipolar thermal diffusion through bandgap widening, and 3) reduce the lattice thermal conductivity by point defect scattering. The results demonstrate that isovalent elements alloying is an effective strategy to realize the promising high performance of septuple atomic layered p -type SnBi 2 Te 4 , which is applicable strategy for AB 2 X 4 based compounds.}, archive = {J_ADVS}, author = {Ke Zhao and Dongyang Wang and Tao Hong and Jiaqi Zhu and Siqi Wang and Shaobo Cheng and Xiang Gao and Chongxin Shan and Li-Dong Zhao}, doi = {10.1002/advs.202506963}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06963}, shortjournal = {Adv. Sci.}, title = {Realizing high performance in P-type SnBi2Te4 through synergistically improving effective mass and suppressing bipolar thermal conductivity}, volume = {12}, year = {2025}, }
• (2025). Chiral 3D perovskite single crystals realized by lattice expansion. ADVS, 12(37), e06902. (www)

  @article{ , abstract = {Chiral 3D perovskites possess remarkable chiroptoelectronic properties, which exhibit potential for overcoming the intrinsic limitations of carrier/exciton dynamics in low-dimensional chiral perovskites. However, chiral 3D perovskites face significant synthetic challenges compared to their low-dimensional counterparts, owing to the large steric hindrance of available chiral organic ammonium cations. Here, a novel chiral 3D perovskite single crystal, [( R / S )-3APr] 2 Pb 4 I 12 ·2H 2 O [( R / S )-3APr = ( R / S )-3-aminopyrrolidine] is demonstrated. The chiral ligands along with water molecules are incorporated inside 3D inorganic frameworks with expanded crystal lattices. An electrode-transfer device fabrication strategy is developed to construct the chiral 3D perovskite-based circularly polarized light (CPL) photodetector. The resulting photodetector exhibits excellent performance, with a high anisotropy factor for photocurrent (g I ph ) of 0.4. Furthermore, the non-centrosymmetry enables chiral 3D perovskites to have efficient second harmonic generation (SHG) properties and a large circular polarization sensitivity of SHG, with an optical anisotropy factor of 0.83, extending the CPL detection range to near infrared region.}, archive = {J_ADVS}, author = {Lin Wang and Wei Hao and Shen Chen and Jie Ren and Hanying Li}, doi = {10.1002/advs.202506902}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06902}, shortjournal = {Adv. Sci.}, title = {Chiral 3D perovskite single crystals realized by lattice expansion}, volume = {12}, year = {2025}, }
• (2025). Engineering DNA origami captors for TGFβ1 sequestration to enhance tumor immune modulation and therapy. ADVS, 12(37), e06827. (www)

  @article{ , abstract = {Efficient modulation of pivotal immune-regulatory molecules to leverage the tumor microenvironment (TME) and enhance therapeutic effects remains an ideal yet challenging goal. TGFβ1 represents a critical therapeutic target as a key cytokine involved in immune suppression and tumor progression. Here, a DNA origami-based framework functionalized with anti-TGFβ1 aptamers is developed to act as a captor for efficient TGFβ1 sequestration and fast clearance, thereby improving anti-tumor immunity. By engineering the geometric shapes and pore sizes of three DNA framework captors (DFCs), the superior efficacy of a barrel-shaped captor (DBC) in regulating TGFβ1 levels is demonstrated. In cell culture, DBCs significantly enhance T cell-mediated tumor cytotoxicity, while systemic administration effectively inhibits tumor growth in the mouse model. Moreover, DBCs demonstrate a synergistic effect with PD-L1 antibody to enhance anti-tumor efficacy. Immunohistochemistry (IHC) further confirmes the DBC-mediated reduction of TGFβ in tumor tissue and its biodistribution fate. These findings underscore the importance of cytokine regulation in cancer immunotherapy and provide valuable insights for the rational design and application of structural DNA nano-devices as a transformative tool for precise immunomodulation.}, archive = {J_ADVS}, author = {Xiao Chen and Dunfang Liu and Jiahui Jin and Han Yao and Yao Sheng and Yarong Liu and Jingwei Sun and Yang Yang}, doi = {10.1002/advs.202506827}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06827}, shortjournal = {Adv. Sci.}, title = {Engineering DNA origami captors for TGFβ1 sequestration to enhance tumor immune modulation and therapy}, volume = {12}, year = {2025}, }
• (2025). One-pot isothermal nucleic acid amplification assisted CRISPR/Cas detection technology: Challenges, strategies, and perspectives. ADVS, 12(37), e06716. (www)

  @article{ , abstract = {The cutting-edge CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)/Cas (CRISPR-associated proteins) system, as an emerging molecular diagnostic technique, is driving revolutionary developments in the detection field due to its high specificity and efficiency. However, the CRISPR-based assays typically require the combination with an additional pre-amplification step based on isothermal nucleic acid amplification to meet the requirements of clinical diagnosis, which brings issues including complicated operation and the risk of aerosol contamination. To address these challenges, one-pot CRISPR platforms are emerging as an attractive solution to streamline workflows, enabling rapid, cost-effective, and high-sensitivity diagnostics. This review outlines the current status, challenges, and three key strategies to realize highly efficient one-pot CRISPR-based detection. In addition, further perspectives are outlined that will inspire new exploration and promote one-pot CRISPR/Cas detection as the next generation of diagnostic tools.}, archive = {J_ADVS}, author = {Hongyan Liu and Hui Yin and Leshan Xiu and Wenyu Wu and Qinqin Hu and Yingchen Xia and Brianna Garcia and Shamsuttiyeba Shifa and Hui Chen and Min Li and Kun Yin}, doi = {10.1002/advs.202506716}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06716}, shortjournal = {Adv. Sci.}, title = {One-pot isothermal nucleic acid amplification assisted CRISPR/Cas detection technology: Challenges, strategies, and perspectives}, volume = {12}, year = {2025}, }
• (2025). Intermediate filament protein BFSP2 controls spindle formation via HSC70-mediated stabilization of CLTC during oocyte meiosis. ADVS, 12(37), e06639. (www)

  @article{ , abstract = {As a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis. However, their specific functions during meiosis are largely unknown. Here, a unique role of an intermediate filament protein beaded filament structural protein 2 (BFSP2) is reported, which is predominantly expressed in lens fiber epithelial cells, as a spindle formation controller in oocyte meiosis. BFSP2 is constantly expressed during oocyte meiotic maturation, and specifically distributed on the spindle apparatus at metaphase I (MI) and metaphase II (MII) stages. Depletion of BFSP2 resulted in the meiotic arrest at MI stage due to the aberrant spindle assembly-induced spindle assembly checkpoint activation. Depletion of BFSP2 also led to incorrect kinetochore-microtubule attachments and the occurrence of aneuploidy in oocytes. Mechanistically, immunoprecipitation combined with mass spectrometry analysis identified clathrin heavy chain 1 (CLTC) as the downstream mediator of BFSP2 during meiotic spindle assembly. It is further determined that BFSP2 recruited the molecular chaperone heat shock cognate protein 70 (HSC70) to the spindle apparatus for stabilizing CLTC, and thus driving the spindle formation. In summary, these findings uncover a noncanonical function of the intermediate filament protein BFSP2 as a spindle assembly controller in oocyte meiosis.}, archive = {J_ADVS}, author = {Yu Li and Zihao Zhang and Yu Zhang and Bo Xiong}, doi = {10.1002/advs.202506639}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06639}, shortjournal = {Adv. Sci.}, title = {Intermediate filament protein BFSP2 controls spindle formation via HSC70-mediated stabilization of CLTC during oocyte meiosis}, volume = {12}, year = {2025}, }
• (2025). Volumetric engineered 3D drug reservoir against diabetic implant infection via cuproptosis-like bacterial death and hunger-triggered maintenance of mitochondrial integrity. ADVS, 12(37), e06554. (www)

  @article{ , abstract = {Implant-associated infections in diabetic patients pose critical challenges due to immune-metabolic dysregulation that exacerbates biofilm persistence and tissue damage. This study introduces a “dimensional rise” strategy integrating 3D-printed porous titanium frameworks with micro-nano hierarchical structures to establish a mechanically robust, high-capacity drug reservoir, surpassing the limitations of conventional 2D surface modifications. Copper-doped carbon quantum dots, synthesized from luteolin, synergize with polydopamine-mediated photothermal activation to disrupt bacterial copper homeostasis, inducing tricarboxylic acid cycle collapse and cuproptosis-like death via reactive oxygen species bursts and lipoylated protein aggregation. Concurrently, glucose oxidase depletes local glucose to activate adenosine 5'-monophosphate-activated protein kinase phosphorylation in host cells, restoring mitochondrial integrity and metabolic homeostasis through deacetylation. This dual-action system achieves differential regulation—targeting bacteria while protecting host tissues—and ensures therapeutic coverage across acute infection and chronic healing phases. Validated in three animal models, including Beagles with clinical-grade implants, the strategy demonstrates potent anti-biofilm efficacy, prevention of secondary infections, and accelerated diabetic osseogenesis. By upgrading surface engineering to 3D volumetric drug reservoirs, this work establishes a paradigm for differentiated multimodal therapy against implant-related infections in metabolically compromised hosts, addressing both immediate bactericidal demands and long-term tissue recovery.}, archive = {J_ADVS}, author = {Dize Li and Hongrui Qin and Min Jiang and Hongjiang Wei and Hongyong Zhao and Ping Tang and Guangyu Jian and Henny C van der Mei and Tao Chen}, doi = {10.1002/advs.202506554}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06554}, shortjournal = {Adv. Sci.}, title = {Volumetric engineered 3D drug reservoir against diabetic implant infection via cuproptosis-like bacterial death and hunger-triggered maintenance of mitochondrial integrity}, volume = {12}, year = {2025}, }
• (2025). Genomic insights into the origin, high fecundity and environmental adaptation of hu sheep. ADVS, 12(37), e06492. (www)

  @article{ , abstract = {Hu sheep are renowned for their adaptation to high-temperature, humid environments and their high fecundity. Despite serving as the founder species for sheep breeding in China, the genetic mechanisms underlying these desirable traits and the breed's origin have remained unresolved. To address the longstanding challenges in understanding their adaptations and origins, comprehensive analyses utilizing genetic data is conducted from over 300 Hu sheep and ≈200 other Chinese native sheep. The study unveils the migration history of sheep and the formation of the Hu sheep in eastern China. By employing multiple screening methods, this study identifies that the BMPR1B , UNC5C , and GRID2 synergistically contribute to the high fecundity trait in Hu sheep. The coexistence of beneficial genotypes in these genes increase the likelihood of multiple births. Notably, the results suggest a potential coevolution between environmental adaptation and reproductive traits in this breed. Overall, the study provides novel insights into the genetic origin and adaptation of Hu sheep, offering new perspectives for molecular breeding in sheep and other livestock species.}, archive = {J_ADVS}, author = {Zexuan Liu and Na Zhang and Zilong Wen and Haitao Wang and Tingting Li and Runlin Ma and Menghua Li and Daxiang Wang and Haiping Shu and Xun Huang and Jianlin Han and Yiqiang Zhao and Qiuyue Liu}, doi = {10.1002/advs.202506492}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06492}, shortjournal = {Adv. Sci.}, title = {Genomic insights into the origin, high fecundity and environmental adaptation of hu sheep}, volume = {12}, year = {2025}, }
• (2025). Polarization decoupling multi-port beam-splitting metasurface for miniaturized magneto-optical trap. ADVS, 12(37), e06289. (www)

  @article{ , abstract = {In regular magneto-optical trap (MOT) systems, the delivery of six circularly polarized (CP) cooling beams requires complex and bulky optical arrangements including waveplates, mirrors, retroreflectors, etc. To address such technique challenges, a beam delivery system for miniaturized MOT is proposed entirely based on meta-devices. The key component is a novel polarization decoupling multi-port beam-splitting (PD-MPBS) metasurface that relies on both propagation phase and geometric phase. The fabricated samples exhibit high beam-splitting power uniformity (within 4.4%) and polarization purities (91.3–93.2%). By leveraging such a beam-splitting device as well as a reflective beam-expanding meta-device, an integrated six-beam delivery system for miniaturized MOT application is implemented. The experimental results indicate that six expanded beams have been successfully delivered with uniform power (within 9.5%), the desired CP configuration, and a large overlapping volume (76.2 mm 3 ). It is believed that a miniaturized MOT with the proposed beam delivery system is very promising for portable application of cold atom technology in precision measurement, atomic clock, quantum simulation, and computing, etc.}, archive = {J_ADVS}, author = {Tian Tian and Chen Qing and Yuxuan Liao and Jiajun Zhu and Yongzhuo Li and Xue Feng and Dengke Zhang and Yidong Huang}, doi = {10.1002/advs.202506289}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06289}, shortjournal = {Adv. Sci.}, title = {Polarization decoupling multi-port beam-splitting metasurface for miniaturized magneto-optical trap}, volume = {12}, year = {2025}, }
• (2025). Boron difluoride formazanate dye with donor planarization engineering for 1060 nm laser activated photothermal theranostics. ADVS, 12(37), e06226. (www)

  @article{ , abstract = {Phototheranostics within the second near-infrared (NIR-II, 1000–1700 nm) window offer considerable advantages compared to those operating in the visible and first near-infrared region (NIR-I, 700–900 nm). Herein, a donor-acceptor-donor (D-A-D) structured NIR-II absorbing Boron Difluoride Formazanate (BDF) dye FBDFDPA is developed through a donor engineering strategy for 1060 nm laser-excited photoacoustic imaging (PAI)-guided photothermal therapy (PTT). By replacing the donor unit from alkoxy-substituted triphenylamine with alkoxy-substituted diphenylamine, the planarity of the molecular conjugated skeleton is enhanced, thus promoting the intramolecular charge transfer (ICT) effect, leading to a 138 nm redshift in absorption and extending it into the NIR-II region. FBDFDPA NPs show excellent molar extinction coefficient (ε = 7.66 × 10 3 M −1 cm −1 ) at 1060 nm and significant photothermal conversion efficiency ( η = 54.4%), enabling effective NIR-II PTT for tumor ablation under the guidance of NIR-II PAI. This work establishes a donor planarization engineering strategy for designing NIR-II absorbing dyes, offering a promising avenue for advanced cancer photothermal theranostics.}, archive = {J_ADVS}, author = {Kang Xu and Mengchen Luo and Weili Wang and Tian Zhang and Yang Chen and Jinjun Shao and Peng Chen and Xiaochen Dong and Yu Cai}, doi = {10.1002/advs.202506226}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06226}, shortjournal = {Adv. Sci.}, title = {Boron difluoride formazanate dye with donor planarization engineering for 1060 nm laser activated photothermal theranostics}, volume = {12}, year = {2025}, }
• (2025). Microfluidic biochip-based multiplexed profiling of small extracellular vesicles proteins integrated with machine learning for early disease diagnosis. ADVS, 12(37), e06167. (www)

  @article{ , abstract = {Accurate early diagnosis is essential for preventing diseases and improving cure and survival rates. There are no reliable early-diagnosis biomarkers for most major diseases. Here, esophageal squamous cell carcinoma (ESCC) is used as a disease model to develop a platform for detecting a panel of proteomic biomarkers for accurate early diagnosis by integrating a barcode immunoassay biochip with machine learning. The biochip captures small extracellular vesicles (EVs) from serum, lyses them in situ, and quantifies multiple proteins, including membrane and internal proteins of EVs. It is utilized to test 273 clinical samples across multiple centers. The validation sets are then analyzed using machine learning, resulting in a precise diagnostic model for ESCC. This model, based on nine diagnostic protein biomarkers identified through mass spectrometry analysis of differentially expressed proteins, achieves an accuracy of 91.0% in external validation, with a 90.8% accuracy in detecting early-stage ESCC. These results significantly surpass the accuracy (only 14.4%) of the currently used biomarker for squamous cell carcinoma. Thus, integrating extracellular vesicles protein analysis with machine learning presents can identify ESCC patients. The developed extracellular vesicles analysis platform offers a promising tool for the clinical application of multi-biomarker detection methods, advancing the early diagnosis of ESCC.}, archive = {J_ADVS}, author = {Xue Zhang and Yibin Jia and Zhikai Li and Yunhong Zhang and Chao Wang and Yanbo Liang and Jiaoyan Qiu and Mingyuan Sun and Xiaoshuang Chen and Miao Huang and Yu Zhang and Jianbo Wang and Hong Liu and Chuanbin Mao and Lin Han}, doi = {10.1002/advs.202506167}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06167}, shortjournal = {Adv. Sci.}, title = {Microfluidic biochip-based multiplexed profiling of small extracellular vesicles proteins integrated with machine learning for early disease diagnosis}, volume = {12}, year = {2025}, }
• (2025). Adipose tissue macrophages as initiators of exacerbated periodontitis in estrogen-deficient environments via the amplifier extracellular vesicles. ADVS, 12(37), e06121. (www)

  @article{ , abstract = {Periodontitis in menopausal women tends to exacerbate, potentially resulting in tooth loss and increased risk of systemic diseases. The prior research demonstrates that pro-inflammatory changes in macrophages under estrogen deficiency exacerbate periodontitis. However, the primary environmental factors contributing to the alteration of monocyte-macrophages remain unknown. Recent studies, including animal models and clinical trials, have found a correlation between accumulation of visceral adipose tissue (VAT) and periodontitis progression in postmenopausal women. In estrogen-deficient mice, macrophages in VAT show a pro-inflammatory state. Removing VAT alleviates periodontitis in OVX mice. DNA methylation sequencing shows increased methylation in macrophages, especially Jazf1 hypermethylation, inhibiting its expression and promoting inflammation. Subsequently, small extracellular vesicles (sEVs) derived from pro-inflammatory macrophages further intensify M1-like polarization in resting macrophages, carrying inflammatory microRNAs like miR-30e-5p. Overall, this study proposes a novel perspective: periodontal pathogens act as initial triggers for inflammation, while chronic systemic inflammation, worsened by estrogen deficiency, is the main factor that exacerbates periodontitis. Pro-inflammatory macrophages in VAT release sEVs, which activate resting macrophages into a pro-inflammatory state upon encountering periodontal pathogens, resulting in persistent inflammation. Addressing the root causes of this dysregulation can lead to new therapeutic strategies for periodontitis and systemic inflammatory conditions, particularly in postmenopausal women.}, archive = {J_ADVS}, author = {Danfeng Li and Tian Yang and Yuqian Li and Xinwei Lyu and Cheng Hu and Jiayin Yan and Jiali Tan}, doi = {10.1002/advs.202506121}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06121}, shortjournal = {Adv. Sci.}, title = {Adipose tissue macrophages as initiators of exacerbated periodontitis in estrogen-deficient environments via the amplifier extracellular vesicles}, volume = {12}, year = {2025}, }
• (2025). Genetic evidence supporting a role for brain region volume and functional network alterations in major depression. ADVS, 12(37), e06032. (www)

  @article{ , abstract = {Despite emerging evidence of altered brain region volumes and functional networks in major depression (MD), causal relationships remain unexplored. Here, using genetic variants related to human brain morphometry ( n = 36778) and functional networks ( n = 47276), bidirectional two-sample and multivariable Mendelian randomization (MR) is performed to systematically investigate causal relationships between 83 brain-wide volumes, 191 resting-state functional magnetic resonance imaging phenotypes, and MD to identify core brain region volumes and functional networks associated with MD onset. Unlike other severe psychiatric disorders, reductions in left and right ventral diencephalon and thalamus volumes, together with decreased functional connectivity between the precuneus, cuneus, or cingulate gyri and frontal regions within the triple network (default mode network, central executive network, and salience network) uniquely predict MD onset. Using the identified markers as mediators in two-step MR recommends quitting smoking, moderately increasing alcohol frequency without developing alcohol use disorder, engaging in walking for leisure, and participating in exercises (e.g., swimming, cycling, keep fit, bowling) to positively influence imaging phenotypes and reduce MD risk. These findings enhance the understanding of predictive outcomes in brain imaging and support proactive prevention of severe mental health disorders through behavioral modifications.}, archive = {J_ADVS}, author = {Ming-Min Xu and Nan Li and Yi-Wen Lv and Wen-Miao Yang and Zhi-Yun Yu and Yi-Min Zhang and Yu Guo and Xiao-Yin Chen}, doi = {10.1002/advs.202506032}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e06032}, shortjournal = {Adv. Sci.}, title = {Genetic evidence supporting a role for brain region volume and functional network alterations in major depression}, volume = {12}, year = {2025}, }
• (2025). Pulsed laser synthesis of carbon nanostructures from organic molecular liquids: Structure, kinetics and photophysical properties. ADVS, 12(37), e05883. (www)

  @article{ , abstract = {The striking one-step bottom-up synthesis of carbon nanoparticles (CNPs) from visible and near infrared (NIR) light transparent air-equilibrated liquid aromatic compounds (benzene, toluene, chlorobenzene, aniline, pyrrole, and thiophene) under unfocused pulsed nanosecond laser irradiation (532/1064 nm) is reported. The formation of CNPs follows zero-order kinetics with an induction period dependent on the reactivity of the organic precursor. Experimental evidence suggests a surface-catalyzed photochemical process involving a partial change in C-atom hybridization from sp 2 to sp 3 , with oxygen-based functional groups passivating the surface of the nanostructures. The presence of additional heteroatoms depends on the structure and composition of the precursor. Contingent on the starting compound, the prepared CNPs can be classified as amorphous carbon nanodots (CNDs) or layered curved-graphene quantum dots (c-GQDs), resembling nano-onion fragments. CNDs are obtained from substituted benzenes or heterocyclic compounds, whereas c-GQDs can be synthesized from benzene. Photophysical characterization of the CNPs shows both wavelength-dependent excitation and emission bands, with constant emission quantum yields in the 1–10% range, and wavelength-dependent emission decays displaying several lifetime components in the range 1–20 ns. Triplet exciton lifetimes longer than 5 µs and wavelength-dependent singlet oxygen production quantum yields in the 10–40% range have been measured.}, archive = {J_ADVS}, author = {Antonio Ribeiro-González and Carlos Agudo-Blanco and Sergio Ramírez-Barroso and Cristina Navío and Luis Bañares and Roger Bresolí-Obach and Santi Nonell and Nazario Martín and David García-Fresnadillo}, doi = {10.1002/advs.202505883}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05883}, shortjournal = {Adv. Sci.}, title = {Pulsed laser synthesis of carbon nanostructures from organic molecular liquids: Structure, kinetics and photophysical properties}, volume = {12}, year = {2025}, }
• (2025). Deciphering the acetabular labrum's cellular atlas: MDK inhibition as a novel therapeutic method for developmental dysplasia of the hip. ADVS, 12(37), e05803. (www)

  @article{ , abstract = {DDH is far more than just a contributing factor to hip osteoarthritis; it represents a formidable challenge to the health of infants and young children. While historical research has largely focused on the osseous abnormalities associated with DDH, current surgical interventions, though prevalent, often carry significant and unavoidable side effects. To break through these limitations, the study delved into the acetabular labrum, a crucial intra-articular structure that presents abnormalities in DDH patients. Through single-cell combined spatial transcriptomic analysis of the acetabular labrum under diverse conditions, a comprehensive examination of the changes of DDH tissue changes at the single-cell level is pioneered, conclusively linking aberrant fibrocartilage stem/progenitor cell proliferation to disease progression. The subsequent in vivo and in vitro experiments unequivocally identify the MK signaling pathway as a pivotal target for DDH treatment. Localized administration of its specific inhibitor not only substantially alleviates early structural abnormalities in DDH but also lays a robust and promising foundation for the innovation and clinical translation of new therapeutic strategies for DDH. In summary, the findings not only deepen the understanding of DDH pathogenesis but also pave the way for innovative therapeutic strategies that prioritize both efficacy and safety.}, archive = {J_ADVS}, author = {Runze Yang and Huiling Liu and Minghao Ge and Dingyuan Zhang and Tianhao Xu and Lei Zhang and Yanlin Zhu and Shun Li and Jian Li and Xin Ma and Weili Fu}, doi = {10.1002/advs.202505803}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05803}, shortjournal = {Adv. Sci.}, title = {Deciphering the acetabular labrum's cellular atlas: MDK inhibition as a novel therapeutic method for developmental dysplasia of the hip}, volume = {12}, year = {2025}, }
• (2025). Inhibition of AMPKα pathway by podocyte GOLM1 exacerbates diabetic nephrology in mice. ADVS, 12(37), e05695. (www)

  @article{ , abstract = {Inflammation and oxidative stress contribute to diabetic nephrology (DN) progression. Golgi membrane protein 1 (GOLM1) is a Golgi type II transmembrane protein and associates with inflammation and oxidative stress. The present study tries to investigate the role and mechanism of GOLM1 in DN using gain- and loss-of-function approaches. It is found that GOLM1 expression is elevated in diabetic kidneys and high glucose-stimulated podocytes, and positively correlated with renal dysfunction during DN progression. Podocyte-specific GOLM1 ablation prevents, while podocyte-specific GOLM1 overexpression facilitates diabetes-related inflammation, oxidative damage, apoptosis, and renal dysfunction in vivo and in vitro. Mechanistic studies reveal that podocyte-specific GOLM1 ablation attenuated DN through activating adenosine monophosphate activated protein kinase α (AMPKα) pathway, and inhibiting AMPKα pathway completely abolishes the beneficial effects in podocyte-specific GOLM1 knockout ( Golm1 pKO ) mice or podocytes. Further findings imply that podocyte GOLM1 inactivated AMPKα pathway through interacting with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ. Moreover, treatment with GOLM1 neutralizing antibody is sufficient to alleviate DN in mice. Overall, the study for the first time identifies a pathogenic role of podocyte GOLM1 in the progression of DN, and inhibiting GOLM1 represents an attractive therapeutic approach to treat DN.}, archive = {J_ADVS}, author = {Peng Xu and Kaiqiang Li and Huasong Liu and Aibo Xu and Zhewei Zhang and Yimin Yang and Xiaobo Lai and Ke Hao and Kui Fang and Zeyu Lai and Xiping Ou and Yuqun Cai and Zhen Wang and Keda Lu and Wanli Jiang}, doi = {10.1002/advs.202505695}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05695}, shortjournal = {Adv. Sci.}, title = {Inhibition of AMPKα pathway by podocyte GOLM1 exacerbates diabetic nephrology in mice}, volume = {12}, year = {2025}, }
• (2025). Mortalin and PINK1/Parkin-mediated mitophagy represent ovarian cancer-selective targets for drug development. ADVS, 12(37), e05592. (www)

  @article{ , abstract = {Mortalin is an essential chaperone for the import of nuclear-encoded proteins into mitochondria and is elevated in ovarian cancer in association with poor patient prognosis. The investigational new drug, SHetA2, interacts with mortalin releasing its client proteins. In this study, interactions of SHetA2 moieties and mortalin substrate binding domain (SBD) amino acids are demonstrated by surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR) to occur at low micromolar SHetA2 concentrations that selectively kill cancer cells over noncancerous cells. In both ovarian cancer and noncancerous cells SHetA2 reduces: mitochondria import of mortalin, degradation of mortalin's mitochondrial localization sequence (MLS), mortalin/inositol 1,4,5-trisphosphate receptors complexes and oxidative phosphorylation. In cancer cells only, SHetA2 reduces calcium levels, mitochondrial length and fusion proteins, while inducing autophagy and PTEN-induced kinase 1 (PINK1)/PARKIN-mediated mitophagy. Noncancerous cells exhibit increased mitochondrial branch length in response to SHetA2 and a low level of inducible autophagy that is resistant to SHetA2. Inhibition of autophagosome-lysosome fusion reduces, or increases, SHetA2 cytotoxicity in ovarian cancer or noncancerous cells, respectively. SHetA2 inhibits mortalin and growth, and induces mitophagy in ovarian cancer xenografts and increases survival post-surgical tumor removal. In conclusion, SHetA2 binds directly to mortalin's SBD and causes distinct responses in ovarian cancer and noncancerous cells.}, archive = {J_ADVS}, author = {Vishal Chandra and Justin Garland and Rajani Rai and Donghua Zhao and Charuksha Walgama and Sadagopan Krishnan and Andrew T. Long and Tongzu Liu and Laura Adhikari and Doris M. Benbrook}, doi = {10.1002/advs.202505592}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05592}, shortjournal = {Adv. Sci.}, title = {Mortalin and PINK1/Parkin-mediated mitophagy represent ovarian cancer-selective targets for drug development}, volume = {12}, year = {2025}, }
• (2025). API5 phosphorylation promotes antiviral immunity by inhibiting degradation of cytosolic RNA sensor RLRs. ADVS, 12(37), e05479. (www)

  @article{ , abstract = {Ubiquitin-mediated selective autophagy is essential for innate immune responses against pathogens. However, the role of apoptosis inhibitor 5 (API5), in governing both ubiquitin-mediated autophagy and antiviral immunity, are poorly defined. Here, it is found that the serine/arginine-rich protein kinase 1 (SRPK1)-dependent phosphorylation of API5 at S464 site is essential for priming antiviral immune responses during diverse RNA virus infection. Mechanistically, phosphorylated API5 forms complexes with autophagic receptor p62 and eliminates itself from ubiquitination at K141, thereby reducing p62 aggregations and inhibiting the autophagic degradation of cytosolic RNA sensors RIG-I and MDA5 to mobilize RLR-mediated antiviral responses. Taken together, it is unveiled that API5 phosphorylation by SRPK1 is required for the inhibition of ubiquitin-mediated autophagic degradation of RNA sensors, revealing a coordinating nature of virus–host interactions that sustains host antiviral defenses.}, archive = {J_ADVS}, author = {Tingjuan Deng and Jianan Xu and Linglong Qin and Xingbo Wang and Chenhe Lu and Yanming Huang and Da Liu and Yan Yan and Weiren Dong and Pinglong Xu and Jiyong Zhou}, doi = {10.1002/advs.202505479}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05479}, shortjournal = {Adv. Sci.}, title = {API5 phosphorylation promotes antiviral immunity by inhibiting degradation of cytosolic RNA sensor RLRs}, volume = {12}, year = {2025}, }
• (2025). A molecular recruitment colocalization platform for visualizing multi-protein interactions and engineering biomolecular condensates in living cells. ADVS, 12(37), e05455. (www)

  @article{ , abstract = {Visualizing dynamic protein–protein interactions (PPIs) and phase-separated biomolecular condensates in live cells is crucial for understanding cellular processes. Here, a method is introduced for analyzing both PPIs and condensates, termed molecular recruitment colocalization (MRC), which localizes interacting partners and generates fluorescent signals at designated genomic loci. MRC enables the simultaneous visualization of multi-protein interactions and the preliminary estimation of binding affinities during PPIs. Through MRC, the study can quickly discover and validate new proteins or structural domains capable of forming condensates and can also integrate PPIs to study condensates. Furthermore, the versatility of MRC is demonstrated in phase-separated condensates research: programming phase separation sites to study the interactions and behaviors between different condensates, recruiting target proteins into programmable condensates, obtaining the properties of diverse engineered condensates, and probing the physical properties of condensates within live cells. Therefore, MRC can become a versatile platform for studying both PPIs and biomolecular condensates.}, archive = {J_ADVS}, author = {Lei Peng and Yu Hou and Yan Zhao and Jing-Ya Tang and Liu Song and Bo Peng and Min Li and Dian-Bing Wang and Xian-En Zhang}, doi = {10.1002/advs.202505455}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05455}, shortjournal = {Adv. Sci.}, title = {A molecular recruitment colocalization platform for visualizing multi-protein interactions and engineering biomolecular condensates in living cells}, volume = {12}, year = {2025}, }
• (2025). Lead halide perovskite nanocrystals in metal-organic frameworks: Synthesis, properties, and applications. ADVS, 12(37), e05407. (www)

  @article{ , abstract = {Halide perovskite nanocrystals (PeNCs) with their exceptional light absorption and tunable bandgap, are promising candidates for solar energy harvesting and high-performance photodetectors. However, the susceptibility of PeNCs to degradation limits their widespread application. The integration of halide perovskites within metal-organic frameworks (MOFs) has recently garnered significant attention as a strategy to create composite materials. The above encapsulation enhances the stability of perovskites against environmental stressors, such as humidity, temperature, and light, leading to improved performance characteristics. This paper provides a comprehensive review of perovskite–metal–organic framework composites (PeMOFs) and their applications in photoelectric conversion. It explores the various preparation methods for PeMOFs and highlights recent advancements in the field. The review examines the specific functions of MOFs within these composite materials and summarizes recent progress in a range of applications, including photocatalysis, sensing, light-emitting diodes, perovskite solar cells, luminescent anti-counterfeiting, information security, and detection. Finally, the paper discusses potential future trends and emerging applications for PeMOFs.}, archive = {J_ADVS}, author = {Xiaochen Fang and Zhijie Xie and Swellam Sharshir and Hanhui Lei and Jiaxian Zheng and Biao Zheng and Xiangfeng Lin and Xiaoteng Liu and Zhanhui Yuan}, doi = {10.1002/advs.202505407}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05407}, shortjournal = {Adv. Sci.}, title = {Lead halide perovskite nanocrystals in metal-organic frameworks: Synthesis, properties, and applications}, volume = {12}, year = {2025}, }
• (2025). Commensal viruses promote intestinal stem cell regeneration following radiation damage by inhibiting hyperactivation of RIG-I and notch signals. ADVS, 12(37), e05204. (www)

  @article{ , abstract = {Radiation-induced intestinal injury is a common complication of abdominopelvic cancer radiotherapy, often associated with gut bacteriome dysbiosis. However, the involvement of gut virome in this process remains largely underexplored. Here, it was found that radiation disrupted the gut virome, altered the distribution of phages and their bacterial host. Fecal virome transplantation (FVT) from healthy donors ameliorated radiation-induced intestinal damage and promoted stem cell proliferation by enriching phages targeting Salmonella . Conversely, decreased virome load exacerbated intestinal damage, reduced proliferating stem cells, and impaired secretory lineage differentiation. Mechanistically, exacerbated intestinal injury was associated with hyperactivation of RIG-I and Notch signaling in intestinal stem cells, which was absent in RIG-I-deficient mice. Organoids from RIG-I-deficient mice displayed decreased Notch signals and increased regenerative capacity post radiation. These findings shed light on the intricate interplay between gut virome, intestinal injury, and stem cell responses, highlighting potential therapeutic interventions for targeting the virome to mitigate radiation-induced intestinal damage.}, archive = {J_ADVS}, author = {Xiaotong Zhao and Yu Cai and Yujia Hou and Yanjin Wu and Tingting Wei and Lili Li and Zhaojun Duan and Xinran Lu and Jiahui Meng and Haitao Zhou and Qin Wang and Jinhan Wang and Chang Xu and Liqing Du and Saijun Fan and Feng Wang and Qiang Liu and Yang Liu}, doi = {10.1002/advs.202505204}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05204}, shortjournal = {Adv. Sci.}, title = {Commensal viruses promote intestinal stem cell regeneration following radiation damage by inhibiting hyperactivation of RIG-I and notch signals}, volume = {12}, year = {2025}, }
• (2025). Adaptive antioxidant nanomedicines inhibit ferroptosis in renal tubular epithelial cells to alleviate diabetic kidney disease. ADVS, 12(37), e05168. (www)

  @article{ , abstract = {Diabetic kidney disease (DKD) imposes a heavy medical burden worldwide due to the lack of effective treatment. High levels of mtROS and mitochondrial damage in the renal tubules are the initiating and core factors driving the progression of DKD. However, the effectiveness of current antioxidant drugs is greatly limited, mainly due to the difficulty of simultaneously breaching the glomerular barrier and targeting tubular mitochondria, as well as their limited ability to sustain treatment of chronic DKD. Here, this study reports a Se embedded adaptive antioxidant nanodrug (AAN) with negative surface charge and high mitochondrial targeting that can pass through the renal tubules and be highly enriched in the affected renal tubular mitochondria in DKD. AAN can eliminate mtROS to release soluble Se, which is then converted into the key bioactive enzymes -GPX4, effectively inhibiting ferroptosis and protecting mitochondria by exerting adaptive antioxidant effects. In the DKD mouse model, AAN treatment can effectively restore renal function, and the therapeutic effect at a dose of 10 mg kg −1 every 4 days is significantly better than Metformin administered at a dose of 200 mg kg −1 per day. In conclusion, this study provides a promising strategy to enhance the effects of antioxidant therapy to break the pathological barriers in DKD treatment.}, archive = {J_ADVS}, author = {Zerun Liu and Ting Huang and Ying Hong and Yuqi Yang and Wensheng Chen and Qingtao Zeng and Qiaohui Chen and Yongqi Yang and Xiaohong Ying and Wan Zeng and Ziyu Wu and Tianjiao Zhao and Xuesi Wan and Jianlin Chen and Kelong Ai and Qiong Huang}, doi = {10.1002/advs.202505168}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e05168}, shortjournal = {Adv. Sci.}, title = {Adaptive antioxidant nanomedicines inhibit ferroptosis in renal tubular epithelial cells to alleviate diabetic kidney disease}, volume = {12}, year = {2025}, }
• (2025). Targeting hyperglycemic bone pre-metastatic niche for breast cancer bone metastasis therapy. ADVS, 12(37), e04924. (www)

  @article{ , abstract = {Bone is the most common site of breast cancer metastasis, yet understanding the intricate mechanisms and potential therapeutic targets remains nascent. Here it is reported that breast cancer establishes a hyperglycemic bone pre-metastatic niche before migrating to bone tissue and further enhances glucose metabolism following metastatic colonization. An intervention strategy is subsequently proposed targeting glucose metabolism utilizing a biomimetic-engineered enzyme-based nanoplatform. This platform's membrane shielding reduces the interaction between engineered glucose oxidase and circulating glucose, while the engineered enzyme specifically targets glucose metabolism, enabling self-amplifying starvation combined with selective chemotherapy. Such precision can precisely inhibit breast cancer bone metastases and block distal tumor dissemination. This study provides novel insights into the role of glucose metabolism in the pre-metastatic niche and presents a proof-of-concept for metabolic-targeted strategies in breast cancer bone metastasis treatment. This approach holds significant promise for improving therapeutic outcomes in metastatic breast cancer by targeting the metabolic vulnerabilities of the bone microenvironment and halting systemic tumor spread.}, archive = {J_ADVS}, author = {Jianxin Ye and Peng Hu and Rui Zhang and Lei Zhou and Zonghua Luo and Yanan Chen and Shengzhe Ruan and Mengyi Zhu and Huaze Ding and Yike Qian and Yan Xing and Tong Meng and Changping Wang and Dianwen Song}, doi = {10.1002/advs.202504924}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04924}, shortjournal = {Adv. Sci.}, title = {Targeting hyperglycemic bone pre-metastatic niche for breast cancer bone metastasis therapy}, volume = {12}, year = {2025}, }
• (2025). Single-cell transcriptome profiling reveals conserved IFNγ-IL8 signaling-induced antibacterial neutrophil states during bacterial infection. ADVS, 12(37), e04840. (www)

  @article{ , abstract = {Streptococcus agalactiae is a significant pathogen in both humans and animals, yet the immune cell subtype dynamics during infection remain poorly defined. Leveraging the high susceptibility and tractability of Nile tilapia ( Oreochromis niloticus ), 113,356 single immune cells are profiled from head kidney and spleen across multiple infection time points (0, 1, 5, 10, 75 days post-infection and 3 days post-reinfection). This single-cell transcriptomic and flow cytometry analyses revealed distinct activation and transition patterns among neutrophils, macrophages, T cells, and B cells. Neutrophils exhibited early transcriptional remodeling enriched in inflammatory and interferon gamma (IFNγ) signaling pathways. Cross-species integration identified a conserved IFNγ-driven transition toward il8⁺ neutrophils. Furthermore, recombinant interleukin-8 (IL8) enhanced antibacterial responses in tilapia and human neutrophils, while inhibition of STAT1 reduced IL8 expression. IL8 stimulation increased phagocytosis and  reactive oxygen species (ROS） production, supporting its role in neutrophil-mediated bacterial clearance. Together, this findings establish IFNγ-IL8 as a conserved mechanism in vertebrate immunity and a potential target for antibacterial therapies.}, archive = {J_ADVS}, author = {Xue Zhai and Minghao Zhang and Kang Li and Wei Li and Xiaolong Li and Wa Gao and Zhaosheng Sun and Dan Huang and Songqian Huang and Mingli Liu and Zhichao Wu and Jun Zou and Liangbiao Chen and Jialong Yang and Peng Hu}, doi = {10.1002/advs.202504840}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04840}, shortjournal = {Adv. Sci.}, title = {Single-cell transcriptome profiling reveals conserved IFNγ-IL8 signaling-induced antibacterial neutrophil states during bacterial infection}, volume = {12}, year = {2025}, }
• (2025). Hierarchical prediction and perturbation of chromatin organization reveal how loop domains mediate higher-order architectures. ADVS, 12(37), e04799. (www)

  @article{ , abstract = {The genome is folded within the dense cell nucleus in a hierarchical manner, resulting in complex interactions between distinct folding strategies at various length scales. To elucidate how short-range loop domains regulate higher-order structures of the chromatin, such as topologically associating domains (TADs) and compartments, HiCGen is introduced as a hierarchical and cell-type-specific generator based on Swin-transformer architecture. HiCGen predicts genome organization across different spatial scales utilizing DNA sequence and genomic features as inputs. The model enables in silico screening through genetic or epigenetic perturbations on genome architecture, with resolution down to 1 kb. The analysis reveals unexpected linear correlations between loop properties and genome organization at various levels, including insulation degree, compartmentalization, and contact intensity over genomic distances exceeding 10 Mb. Regional or global perturbation conducted by HiCGen provides biological implications for such cross-scale correlations and their genome-function dependence. Notably, perturbation analysis of the human genome in sigmoid colon tissue demonstrates that modest activation of carcinogenesis-associated enhancers is sufficient to hijack nearby promoter, reshape TAD boundaries, and even flip compartment at mega-base scale.}, archive = {J_ADVS}, author = {Jiachen Wei and Yue Xue and Yi Qin Gao}, doi = {10.1002/advs.202504799}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04799}, shortjournal = {Adv. Sci.}, title = {Hierarchical prediction and perturbation of chromatin organization reveal how loop domains mediate higher-order architectures}, volume = {12}, year = {2025}, }
• (2025). Engineered dual-function antibody-like proteins to combat SARS-CoV-2-induced immune dysregulation and inflammation. ADVS, 12(37), e04690. (www)

  @article{ , abstract = {Complement dysregulation and immune hyperactivation are pivotal factors contributing to the mortality associated with SARS-CoV-2 infection. Engineered Antibody-like proteins (ALPs) targeting the SARS-CoV-2 spike protein are engineered to address immune dysregulation in COVID-19. In this study, Lectifitin-36 and Lectifitin-41, two such ALPs, are developed using cDNA display technology. These ALPs demonstrate strong binding affinity for the spike protein and effectively inhibit its interaction with ACE2 and several C-type lectins, including MBL, DC-SIGN, and L-SIGN. Both in vitro and in vivo analyses reveal that Lectifitin-36 and Lectifitin-41 suppress complement activation via the lectin pathway, reduce neutrophil extracellular trap (NET) formation, and attenuate hyper-inflammatory responses. In mouse models, Lectifitin-36 and Lectifitin-41 significantly mitigate inflammation, NETosis, and lung tissue damage induced by the spike protein. These results suggest that these ALPs hold promise as therapeutic candidates for alleviating SARS-CoV-2-induced immune dysfunction, with the potential to reduce severe COVID-19 outcomes and long-term sequelae. This study underscores the therapeutic potential of targeting spike protein-mediated immune modulation as an innovative approach to combat COVID-19.}, archive = {J_ADVS}, author = {Yizhuo Wang and Chenwu Bai and Kerui Hou and Zhen Zhang and Ming Guo and Xin Wang and Fan Yang and Xin Liu}, doi = {10.1002/advs.202504690}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04690}, shortjournal = {Adv. Sci.}, title = {Engineered dual-function antibody-like proteins to combat SARS-CoV-2-induced immune dysregulation and inflammation}, volume = {12}, year = {2025}, }
• (2025). Efficient somatic cell nuclear transfer by overcoming both pre- and post-implantation epigenetic barriers. ADVS, 12(37), e04669. (www)

  @article{ , abstract = {Mammalian cloning through somatic cell nuclear transfer (SCNT) involves reprogramming terminally differentiated cells into totipotent embryos. Epigenetic barriers inherited from somatic cells impede reprogramming efficiency and lead to low SCNT embryo development rates. Recent studies have identified two primary types of epigenetic barriers in mouse SCNT embryos, defective pre-implantation development due to abnormal gene expression around zygotic genome activation, associated with aberrant H3K9me3, H3K4me3, and histone acetylation, and defective post-implantation development due to loss of H3K27me3-mediated non-canonical imprinting. Despite these findings, effective strategies to overcome these barriers in a single embryo have not been established. Here, Kdm4d and Kdm5b overexpression are combined with TSA treatment to overcome epigenetic barriers in pre-implantation development, while using tetraploid complementation to replace extraembryonic lineage cells, thereby overcoming imprinting defects critical for post-implantation development. This approach resulted in ≈30% full-term development efficiency of reconstructed embryos. The strategy not only represents the highest SCNT efficiency achieved in mammals but also enhances the feasibility of efficient mammal cloning.}, archive = {J_ADVS}, author = {Yamei Li and Shiyu Sun and Yuting Xu and Jixiang Zhang and Yi Du and Yaxin Cao and Zhaodi Liao and Yali Xie and Xinyan Bian and Jiantao Huang and Meijiao Wang and Zhen Liu and Qiang Sun and Falong Lu}, doi = {10.1002/advs.202504669}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04669}, shortjournal = {Adv. Sci.}, title = {Efficient somatic cell nuclear transfer by overcoming both pre- and post-implantation epigenetic barriers}, volume = {12}, year = {2025}, }
• (2025). ER-phagy activation by AMFR attenuates cardiac fibrosis post-myocardial infarction via mTORC1 pathway. ADVS, 12(37), e04552. (www)

  @article{ , abstract = {Progressive cardiac fibrosis post myocardial infarction (MI) drives pathological remodeling and heart failure, yet the role of endoplasmic reticulum-selective autophagy (ER-phagy) in this process remains unclear. Autocrine Motility Factor Receptor (AMFR) is a recently identified ER-phagy regulator, whose function under myocardial pathology remains poorly understood. Here, it is found that FAM134B-mediated ER-phagy activity is elevated in fibrotic mouse heart tissues post-MI and in cardiac fibroblasts stimulated by TGF-β1. AMFR knockout in mice aggravated cardiac fibrosis post-MI and worsened cardiac function, with scRNA-seq analysis demonstrating that AMFR-null cardiac fibroblasts exhibit a myofibroblast phenotype. Simultaneously, AMFR overexpression in cardiac fibroblasts reduces the expression of profibrogenic proteins in response to TGF-β1 stimulation. AMFR regulates ER-phagy flux and turnover of FAM134B, which leads to the suppression of cardiac fibroblasts activation. Mechanistically, AMFR catalyzed K27-linked (predominant) and K33-linked ubiquitination of FAM134B and enhanced ER-phagy flux, thereby inhibiting the phosphorylation of mTORC1 downstream targets such as S6K1 and 4E-BP. These findings highlight the therapeutic potential of AMFR-driven ER-phagy in suppressing cardiac fibrosis post-MI.}, archive = {J_ADVS}, author = {Zhixiang Wang and Kaifan Niu and Wei Liu and Xinyun Wang and Boshen Yang and Taixi Li and Yizhi Chen and Yuanyuan Jin and Yu Chen and Yangyi Lin and Xian Jin}, doi = {10.1002/advs.202504552}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04552}, shortjournal = {Adv. Sci.}, title = {ER-phagy activation by AMFR attenuates cardiac fibrosis post-myocardial infarction via mTORC1 pathway}, volume = {12}, year = {2025}, }
• (2025). Dedifferentiation and transfer in executive function and math ability following a five-year abacus training in schoolchildren. ADVS, 12(37), e04518. (www)

  @article{ , abstract = {The cognitive differentiation of executive function (EF) and mathematical ability during child development, characterized by their decreasing correlation, is well established. However, the impact of long-term cognitive training on this developmental effect remains largely unexplored. The present study investigated this by analyzing behavioral and neuroimaging data from schoolchildren who participated in five years of abacus training. The findings indicate that, compared to the control group, the training group exhibits cognitive dedifferentiation, characterized by stronger correlations between EF and mathematical abilities, accompanied by lower inter-individual variability. These observations are consistent with the discovery of greater overlap in behavior-associated brain connectivity patterns and more uniform connectivity profiles across individuals. Furthermore, the individual-to-group similarity in connectivity pattern is significantly associated with EF and mathematical performance, suggesting a shared cognitive strategy shaped by prolonged training. The findings provide empirical evidence in support of neurocognitive plasticity, highlighting the capacity of targeted cognitive training to functionally reshape brain networks and modulate the developmental trajectory of cognitive traits.}, archive = {J_ADVS}, author = {Tianyong Xu and Xinyang Liu and Hongjian He and Changsong Zhou and Andrea Hildebrandt and Feiyan Chen}, doi = {10.1002/advs.202504518}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04518}, shortjournal = {Adv. Sci.}, title = {Dedifferentiation and transfer in executive function and math ability following a five-year abacus training in schoolchildren}, volume = {12}, year = {2025}, }
• (2025). Supramolecular lubricating hydrogel microspheres reshape damaged matrix regeneration. ADVS, 12(37), e04319. (www)

  @article{ , abstract = {Supramolecular lubrication refers to lubricant supplementation utilizing intermolecular noncovalent interactions to remodel lubrication structure at biological interfaces. The previous studies found that lubrication supplementation is closely related to damaged matrix regeneration, but the lubrication structure is prone to disintegration and failure. Here, combining with microfluidic and photopolymerization strategies, a supramolecular lubricating hydrogel microsphere is constructed, which is medicated by dipalmitoylphosphatidylcholine (DPPC) liposomes as the core, a natural component in body fluids, and complexed with cartilage matrix-binding peptide functionalized methacryloylated hyaluronan acid (WYR-HAMA) as the photoinitiated site. The highly intermolecular ion-dipole interaction between DPPC and WYR-HAMA can form a dynamic supramolecular lubricating layer on the damaged matrix interfaces, where inflammatory factor inhibitors are coupled with DPPC liposomes via hydrophobic interaction to resist inflammatory transmission. Additionally, microspheres can autonomously regulate lubrication structure: in the early and middle stages, they can actively provide microscale lubrication (µ ≈ 0.04); in the late stage, the wear debris induced by endogenous enzymatic decomposition transmitted to provide nanoscale lubrication for the damaged matrix (µ ≈ 0.06). In vivo experiments demonstrate microspheres promoted efficient extracellular matrix synthesis and the autonomous release of lubrication factors at the cellular level. The developed bioplatform allowing cellular lubrication metabolism would provide a promising strategy for regenerating friction-induced matrix damage.}, archive = {J_ADVS}, author = {Hui Yuan and Pengcheng Xiao and Wei Huang and Wenguo Cui}, doi = {10.1002/advs.202504319}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04319}, shortjournal = {Adv. Sci.}, title = {Supramolecular lubricating hydrogel microspheres reshape damaged matrix regeneration}, volume = {12}, year = {2025}, }
• (2025). Loss of NR2F6 protects from salmonella typhimurium infection. ADVS, 12(37), e04280. (www)

  @article{ , abstract = {Nuclear receptors regulate key functions of mononuclear phagocytes and are critical components of the innate immune system, acting as regulators of organ health and disease. In healthy mice, the loss of the nuclear orphan receptor NR2F6 alters tissue-resident macrophage populations in the liver, lung, and spleen. In response to Salmonella Typhimurium infection, Nr2f6 -deficient mice exhibit improved clinical outcomes, characterized by reduced weight loss, bacterial loads in the spleen and liver, and decreased plasma pro-inflammatory cytokines. Despite unchanged basal iron metabolism in the spleen and liver, iron regulatory proteins and the interleukin (IL)-6-hepcidin axis are altered in Nr2f6- deficient mice during Salmonella infection, reducing hypoferremia. Transcriptomic analysis of splenic red pulp macrophages reveals significant alterations of phagocytosis-related genes, including upregulation of signal-regulatory protein alpha (Sirpa). In vitro, phagocytosis of red blood cells, regulated by the inhibitory CD47-Sirpα axis, and Salmonella Typhimurium phagocytosis are significantly impaired in Nr2f6 -deficient splenic macrophages. Blocking Sirpα in vitro restores the phagocytic activity of Nr2f6 -deficient macrophages to wild-type levels. In vivo , Salmonella Typhimurium loads are partially increased post-infection in anti-Sirpα treated Nr2f6 -deficient mice. These findings uncover a previously unrecognized role of NR2F6 in host-pathogen interactions, positioning it as a potential therapeutic target for infectious diseases.}, archive = {J_ADVS}, author = {Johannes Woelk and Christa Pfeifhofer-Obermair and Julia Benz and Natascha Brigo and Milena Bamberger and Alexeja Kleiter and Martin Hermann and Guenter Weiss and Natascha Hermann-Kleiter}, doi = {10.1002/advs.202404280}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04280}, shortjournal = {Adv. Sci.}, title = {Loss of NR2F6 protects from salmonella typhimurium infection}, volume = {12}, year = {2025}, }
• (2025). Aberrant mitochondrial metabolism in alzheimer's disease links energy stress with ferroptosis. ADVS, 12(37), e04175. (www)

  @article{ , abstract = {Alzheimer's disease (AD) is defined by β-amyloid plaques and tau-containing neurofibrillary tangles, but the ensuing cellular derangements that culminate in neurodegeneration remain elusive. Here, a mechanistic link between two AD pathophysiological hallmarks: energy insufficiency and oxidative stress is revealed. It is demonstrated that mitochondrial function and glutathione (GSH) flux are coupled, impacting neuronal ferroptosis susceptibility. Analysis of proteomic data from the inferior temporal cortex of 625 subjects along a continuum of clinical and pathological changes in AD, reveals a prominent depletion of mitochondrial proteins. Biogenetic insufficiency in AD is reflected by a concurrent loss of GSH, which requires 2 ATP for its synthesis, and genetic and pharmacologic ATP depletion models confirm that ATP is rate-limiting for GSH. Accordingly, an unbiased association analysis uncovers mitochondrial proteins in positive correlation with total GSH (t-GSH) in AD subjects. But mitochondria also consume GSH via the SLC25A39 transporter. It is found that mitochondrial inhibition either increases or decreases ferroptosis susceptibility in cellular models, depending on contextual factors that dictate whether mitochondria act as a net GSH producer or consumer, respectively. Mitochondria therefore control GSH flux, and loss of energy output is consequently demonstrated as a liability for ferroptosis in AD.}, archive = {J_ADVS}, author = {Francesca Alves and Darius Lane and Adam Wahida and Md. Jakaria and Pawel Kalinowski and Adam Southon and Abdel Ali Belaidi and Teresa Samperi-Esteve and Triet Phu Minh Nguyen and Peng Lei and Marcus Krueger and Stefan Mueller and Marcus Conrad and Puja Agarwal and Sue E Leurgans and Julie Schneider and Ashley I. Bush and Scott Ayton}, doi = {10.1002/advs.202504175}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04175}, shortjournal = {Adv. Sci.}, title = {Aberrant mitochondrial metabolism in alzheimer's disease links energy stress with ferroptosis}, volume = {12}, year = {2025}, }
• (2025). BCG-derived outer membrane vesicles induce TLR2-dependent trained immunity to protect against polymicrobial sepsis. ADVS, 12(37), e04101. (www)

  @article{ , abstract = {Trained immunity, an innate immune memory, has emerged as a promising strategy to enhance host defense against sepsis, a leading cause of mortality in critical care. While Bacillus Calmette–Guérin (BCG) is the most widely used vaccine for tuberculosis prevention, its broader use as an inducer of trained immunity is limited by adverse reactions. Here, it is reported that BCG-derived outer membrane vesicles (B-OMVs) effectively trigger trained immunity to protect against experimental polymicrobial sepsis. Comprehensive characterization and safety assessments confirmed that B-OMVs exhibited no significant toxicity or pathological effects, positioning them as a promising alternative to conventional BCG vaccines and E. coli -derived outer membrane vesicles (E-OMVs) in terms of both efficacy and safety. Mechanistically, B-OMVs enhanced trained immunity by promoting hematopoietic stem cell expansion and myelopoiesis via toll like receptor 2 (TLR2)-dependent activation of aerobic glycolysis and epigenetic reprogramming. This led to an amplified immune response and enhanced phagocytic activity in bone marrow-derived macrophages. Together, these findings establish B-OMVs as a novel immunomodulatory agent against sepsis-induced immune dysfunction, with translational potential.}, archive = {J_ADVS}, author = {Yuan Gong and Wenyan Hao and Lingqi Xu and Yingyi Yang and Zhenzhen Dong and Peng Pan and Zhenjiang Bai and Jie Huang and Kaidi Yang and Zhu Jin and Rui Kang and Qiang Shan and Jiang huai Wang and Zijian Zhou and Daolin Tang and Jian Wang and Huiting Zhou}, doi = {10.1002/advs.202504101}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04101}, shortjournal = {Adv. Sci.}, title = {BCG-derived outer membrane vesicles induce TLR2-dependent trained immunity to protect against polymicrobial sepsis}, volume = {12}, year = {2025}, }
• (2025). Pancreatic cancer-derived extracellular vesicles enriched with miR-223-5p promote skeletal muscle wasting associated with cachexia. ADVS, 12(37), e04064. (www)

  @article{ , abstract = {Pancreatic ductal adenocarcinoma (PDAC) with cachexia-related muscle wasting as the main manifestation is associated with poor overall survival. Extracellular vesicles (EVs) are key mediators of inter-organ communication. Here, EVs and EV-microRNAs (miRNAs) are identified as mediate PDAC-skeletal muscle communication. EVs are isolated from PDAC patients, mouse models, patients-derived organoids, and mouse pancreatic cancer cells. Plasma-derived EVs from PDAC patients or mice are observed to remarkably induced muscle wasting in vitro and in vivo. Depletion of miRNA cargo in these EVs significantly alleviates their detrimental effects on skeletal muscles. Deep RNA sequencing is conducted to profile differentially expressed miRNAs in plasma EVs from patients with or without PDAC. The findings reveal that the expression of miR-223-5p expression in PDAC patients’ plasma EVs is negatively associated with the 3-year overall survival. Mechanistic studies show that miR-223-5p contributes to reduced METTL14 transcription by targeting MAFA, associated with decreased m 6 A methylation in skeletal muscles and muscle wasting. This study highlights the absorption of miRNA in PDAC-derived EVs by skeletal muscles and reveals a previously unrecognized function of PDAC-derived EV-miR-223-5p in tumor-muscle inter-organ communication, offering novel insight into EV-miR-223-5p-based diagnostic and therapeutic strategies for PDAC patients with sarcopenia upon further validation.}, archive = {J_ADVS}, author = {Kangjing Xu and Rongxi Shen and Li Zhang and Xuejin Gao and Xinbo Wang and Changhua Zhang and Xi Chen and Xinying Wang}, doi = {10.1002/advs.202504064}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e04064}, shortjournal = {Adv. Sci.}, title = {Pancreatic cancer-derived extracellular vesicles enriched with miR-223-5p promote skeletal muscle wasting associated with cachexia}, volume = {12}, year = {2025}, }
• (2025). Regulating a NaF-rich SEI layer for dendrite-free sodium metal batteries using trifunctional halogenated covalent organic framework separators. ADVS, 12(37), e03693. (www)

  @article{ , abstract = {Uncontrolled sodium-ion (Na + ) transport, fragile solid electrolyte interphase (SEI) layers, in and sluggish Na + desolvation using conventional separators drive dendrite growth, posing critical challenges to the development of sodium metal batteries (SMBs). Porous materials with tunable Na + transport pathways offer promise; however, simultaneously enhancing Na + kinetics, promoting NaF-rich SEI formation, and lowering desolvation energy barriers remains a critical challenge. Herein, a trifunctional halogenated covalent organic framework (COF) integrated into a polypropylene (PP) separator (COF-F@PP) is designed to address these issues. The COF-F@PP separator features positively charged sites to anchor PF 6 − anions and facilitate desolvation of NaPF 6 , and in-situ release of fluorine ions from halogenated COF promotes the formation of a robust NaF-rich SEI layer. Additionally, its high-porosity structure enables uniform Na + transport. Theoretical simulation demonstrates that the COF-F@PP separator improves desolvation dynamics, ensures uniform Na + flux distribution, and mitigates local electric field concentration, resulting in smooth and dendrite-free deposition. Consequently, a high Coulombic efficiency (99.2%), excellent ionic conductivity (1.13 mS cm −1 ), and stable cycling for over 1000 h at 3 mA cm −2 are achieved. In Na||NVP full cells, COF-F@PP separator delivers an initial discharge capacity of 83.51 mAh g −1 at 50 C and retains 88.42% of its capacity after 10 000 cycles.}, archive = {J_ADVS}, author = {Muhammad Ali and Hamid Hussain and Moazzam Ali and Samia Aman and Weiwei Yang and Zeeshan Ali and Lei Li and Yinzhu Jiang and Muhammad Yousaf}, doi = {10.1002/advs.202503693}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03693}, shortjournal = {Adv. Sci.}, title = {Regulating a NaF-rich SEI layer for dendrite-free sodium metal batteries using trifunctional halogenated covalent organic framework separators}, volume = {12}, year = {2025}, }
• (2025). Controlling release kinetics of an adjuvant from a depot improves the efficacy of local immunotherapy in metastatic cancer. ADVS, 12(37), e03591. (www)

  @article{ , abstract = {Biomaterials can improve cancer immunotherapies by controlling their release and thereby optimizing their time-dependent engagement of the immune system. In this study, an approach is described to control the release of a potent immunostimulant—CpG oligodeoxynucleotide—from a genetically-encoded elastin-like polypeptide (ELP) depot. A CpG-binding ELP containing an oligolysine domain (ELP-Lys 12 ) is synthesized that electrostatically complexes CpG and formulate it with an excipient ELP. The ELP-CpG complex retains the thermally responsive phase behavior of the parent ELP, transitioning into a viscous depot at body temperature. Stepwise addition of excipient ELP predictably changes ELP-CpG transition temperature, depot dissolution kinetics, and retention of CpG within the depot. Mixtures of ELP-Lys 12 , excipient ELP, and CpG undergo microphase separation, forming a porous, sponge-like depot that contains tunable amounts of soluble CpG in the pores. In vivo, the modified formulations exhibit varying degrees of CpG retention over multiple weeks following a single intratumoral injection. Finally, by modifying the release kinetics of CpG, optimized ELP-CpG achieves greater reduction of metastatic disease in a murine metastatic breast cancer model than soluble CpG. These results demonstrate that ELPs can be used to precisely tune the release kinetics of immunotherapies for better outcomes in the treatment of metastatic cancer.}, archive = {J_ADVS}, author = {Joshua J. Milligan and Rachel L. Strader and Arunangshu Chakrabarty and Max Ney and Parul Sirohi and Jonathan C. Su and Anastasia K. Varanko and Yulia Shmidov and Kalina Tsolova and Cassio Mendes Fontes and Anna Finkelstein and Rohinee Mattikalli and Yun-Xing Wang and Lixin Fan and Xinghai Li and Smita K. Nair and Ashutosh Chilkoti}, doi = {10.1002/advs.202503591}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03591}, shortjournal = {Adv. Sci.}, title = {Controlling release kinetics of an adjuvant from a depot improves the efficacy of local immunotherapy in metastatic cancer}, volume = {12}, year = {2025}, }
• (2025). PIM1 attenuates innate immunity to foster coronavirus replication through ubiquitin ligase β-TrCP-mediated IFNAR1 degradation. ADVS, 12(37), e03487. (www)

  @article{ , abstract = {Virus infection stimulates proto-oncoprotein PIM1 kinase expression, but its importance and the biological functions of this process are poorly understood. Herein, PIM1 promotes IFNAR1 degradation to attenuate cellular innate immunity during human coronavirus HCoV-OC43 infection. During virus replication, the double-stranded viral RNA and some viral proteins upregulate PIM1 expression, which phosphorylates E3 ubiquitin ligase β-TrCP1 at Serine 82. The pS82-β-TrCP1 then forms a complex with S535/S539-phosphorylated interferon receptor IFNAR1 (pS535/539-IFNAR1), leading to IFNAR1 ubiquitination and degradation. Both pan-inhibitors (CX-6528, SGI-1776, AZD-1208) and a specific inhibitor of PIM1 kinase (PIM1 inhibitor 2) effectively block this process and potently inhibit viral replication. This studies demonstrate a novel strategy that viruses use to disrupt cellular innate immunity, suggesting a potential therapeutic target for further anti-virus drug development.}, archive = {J_ADVS}, author = {Qianya Wan and Lin Zhu and Cien Chen and Li Zhong and Houying Leung and Wei Li and Chang Xu and Xi Yao and Huan Hu and Mandi Wu and Yuxin Hou and Hin Chu and Yiran Wang and Sheng Chen and Mingyu Pan and Zongwei Cai and Ming-liang He}, doi = {10.1002/advs.202503487}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03487}, shortjournal = {Adv. Sci.}, title = {PIM1 attenuates innate immunity to foster coronavirus replication through ubiquitin ligase β-TrCP-mediated IFNAR1 degradation}, volume = {12}, year = {2025}, }
• (2025). A near-field coupling array enables parallel imaging and SNR gain in MRI. ADVS, 12(37), e03481. (www)

  @article{ , abstract = {Wireless radiofrequency (RF) coils based on metasurfaces hold great promise for improving clinical magnetic resonance imaging (MRI) workflows by eliminating the need for cable connections to the patient bed and simplifying coil structures. A fundamental requirement for their clinical adoption is the ability to support parallel imaging, which reduces examination time and improves efficiency. Moreover, the implementation of parallel imaging often comes at the expense of image signal-to-noise ratio (SNR). Although several wireless RF coils incorporating metamaterials are reported, most do not support parallel imaging and many deliver suboptimal SNR performance. In this work, a novel wireless RF coil architecture is proposed, termed the near-field coupling array (NFCA), which demonstrates both excellent SNR performance and robust parallel imaging capabilities. A general theoretical framework is presented that establishes a foundation for applying metasurface arrays in magnetic resonance RF coil design. The SNR expression for this architecture is derived from two perspectives, and its fundamental principles are validated through case studies. Experimental results show that the NFCA achieves a 66% SNR improvement over a conventional commercial RF coil architecture (i.e., a wired coil) while its average acceleration factor exceeds 94% of that of the commercial coil.}, archive = {J_ADVS}, author = {Zhiguang Mo and Shao Che and Feng Du and Enhua Xiao and Qiaoyan Chen and Nan Li and Sen Jia and Changjun Tie and Bing Wu and Xiaoliang Zhang and Hairong Zheng and Ye Li}, doi = {10.1002/advs.202503481}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03481}, shortjournal = {Adv. Sci.}, title = {A near-field coupling array enables parallel imaging and SNR gain in MRI}, volume = {12}, year = {2025}, }
• (2025). A machine-learning approach identifies rejuvenating interventions in the human brain. ADVS, 12(37), e03344. (www)

  @article{ , abstract = {The increase in life expectancy has caused a rise in age-related brain disorders. Although brain rejuvenation is a promising strategy to counteract brain functional decline, systematic discovery methods for efficient interventions are lacking. A computational platform based on a transcriptional brain aging clock capable of detecting age- and neurodegeneration-related changes is developed. Applied to neurodegeneration-positive samples, it reveals that neurodegenerative disease presence and severity significantly increase predicted age. By screening 43840 transcriptional profiles of chemical and genetic perturbations, it identifies 453 unique rejuvenating interventions, several of which are known to extend lifespan in animal models. Additionally, the identified interventions include drugs already used to treat neurological disorders, Alzheimer's disease among them. A combination of compounds predicted by the platform reduced anxiety, improved memory, and rejuvenated the brain cortex transcriptome in aged mice. These results demonstrate the platform's ability to identify brain-rejuvenating interventions, offering potential treatments for neurodegenerative diseases.}, archive = {J_ADVS}, author = {Guillem Santamaria and Cristina Iglesias and Sascha Jung and Javier Arcos Hodar and Ruben Nogueiras and Antonio del Sol}, doi = {10.1002/advs.202503344}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03344}, shortjournal = {Adv. Sci.}, title = {A machine-learning approach identifies rejuvenating interventions in the human brain}, volume = {12}, year = {2025}, }
• (2025). Cryogel-based dendritic cell immunotherapy for post-surgical breast cancer treatment. ADVS, 12(37), e03238. (www)

  @article{ , abstract = {Triple-negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options. While surgical resection removes the primary tumor, it often fails to prevent recurrence or metastasis, and despite the promise of immunotherapy, response to immune checkpoint blockade remains poor. Here, a cryogel-based dendritic cell (DC) immunotherapy is developed incorporating gold nanodot-lipopolysaccharide (AuLPS)-loaded DCs, doxorubicin (Dox), and PD-1 immune checkpoint blockade (aPD-1+Dox+AuLPS@DC) to enhance post-surgical antitumor immunity. The AuLPS nanoparticles (NPs) stabilize LPS assembly, optimizing Th1 adjuvant activity and improving DC immunotherapy efficacy while minimizing adverse effects. The cryogel enables the sustained, localized release of therapeutic agents at the surgical site, preserving DC viability, migration, and functionality within the tumor microenvironment. This strategy enhances DC activation and potentiates robust T-cell activation in both tumor-draining lymph nodes and tumor beds, leading to durable antitumor immunity. When administered at the post-surgical site in an orthotopic TNBC model, the aPD-1+Dox+AuLPS@DC cryogel immunotherapy significantly delays tumor recurrence, reduces distant metastasis, and prolongs survival. These findings highlight cryogel-based DC immunotherapy as a promising post-surgical therapeutic strategy to enhance responses to immune checkpoint blockade and improve outcomes in TNBC.}, archive = {J_ADVS}, author = {Lam-Duc-Huy Nguyen and Sheng-Liang Cheng and Yu-Ting Yen and Hsin-Mei Lee and Te-Haw Wu and Jane Wang and Shu-Yi Lin and Yunching Chen}, doi = {10.1002/advs.202503238}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03238}, shortjournal = {Adv. Sci.}, title = {Cryogel-based dendritic cell immunotherapy for post-surgical breast cancer treatment}, volume = {12}, year = {2025}, }
• (2025). NPR1 promotes lipid droplet lipolysis to enhance mitochondrial oxidative phosphorylation and fuel gastric cancer metastasis. ADVS, 12(37), e03233. (www)

  @article{ , abstract = {Metabolic reprogramming driven by oncogenes plays a critical role in promoting and sustaining multiple steps of gastric cancer metastasis. However, the key metabolic driver of metastasis that can lead to the development of targeted therapies for preventing and treating metastatic gastric cancer remains elusive. Here, it is identified that the transmembrane guanylate cyclase, natriuretic peptide receptor 1 (NPR1), promoted gastric cancer lymph node metastasis by activating lipid droplet lipolysis and enhancing mitochondrial oxidative phosphorylation (OXPHOS). Clinical analysis reveals that elevated NPR1 protein level is correlated with increased lymph node metastasis and shorter patient survival. Functionally, NPR1 induced lipolysis of stored lipid droplets, releasing bioavailable fatty acids that are imported into mitochondria to upregulate OXPHOS, thus fueling the energy required for the metastasis of gastric cancer cells. Mechanistically, NPR1 activates protein kinase cGMP-dependent 1 (PRKG1 or PKG), which directly bound to and activated hormone-sensitive lipase (HSL) by phosphorylation at residues Ser 855 and Ser 951 , thereby increasing lipolysis. Furthermore, targeted delivery of NPR1 siRNA using engineered exosome mimetics effectively suppressed gastric cancer metastasis. Taken together, these findings elucidate the NPR1-driven metabolic mechanism underlying gastric cancer metastasis and suggest NPR1 as a promising therapeutic target for patients with metastatic gastric cancer.}, archive = {J_ADVS}, author = {Huafeng Fu and Jie Zhang and Hengxing Chen and Haobin Hou and Huanjie Chen and Rongman Xie and Yanlei Chen and Jian Zhang and Dehua Liu and Leping Yan and Rui L. Reis and Joaquim M. Oliveira and Yulong He and Li Zhong and Qinbo Cai and Dongjie Yang}, doi = {10.1002/advs.202503233}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03233}, shortjournal = {Adv. Sci.}, title = {NPR1 promotes lipid droplet lipolysis to enhance mitochondrial oxidative phosphorylation and fuel gastric cancer metastasis}, volume = {12}, year = {2025}, }
• (2025). Manipulating liquid-liquid interphase solute diffusion for the construction of non-symmetric metal-quinone network nanoarchitectonics and nano-motorization. ADVS, 12(37), e03164. (www)

  @article{ , abstract = {Non-symmetric nanoarchitectonics have demonstrated superior performance in nanotherapeutics compared to their symmetric counterparts, particularly in the design of self-propelled nanodrug delivery systems. However, achieving precise morphological control of non-symmetric nanoarchitectonics composed of molecular drugs, without the use of templates and surfactants, remains a significant challenge. In this work, a strategy is presented to construct non-symmetric metal-quinone network (MQN) nanoarchitectonics with controlled morphology and size by manipulating solute and solvent diffusion behaviors during the nanoprecipitation process. The findings reveal that solute diffusion at the liquid-liquid interface of miscible solvent and antisolvent can be confined by self-generated MQNs, which in turn dictates the morphology of the resulting nanoarchitectonics. By regulating interphase solute diffusion kinetics, a variety of MQN nanoarchitectonics are successfully produced with spherical, semifootball-like, and bowl-like morphologies, ranging in sizes from tens to hundred of nanometers. Notably, the non-symmetric MQN nanobowls are further employed to create self-propelled nanodrugs, which indicates enhanced efficacy in tumor therapy. This study underscores the critical role of liquid-liquid interphase solute diffusion in determining the morphology and size of MQN nanoarchitectonics and highlights the potential of nanoprecipitation as a powerful technique for the precise fabrication of non-symmetric nanoarchitectonics.}, archive = {J_ADVS}, author = {Wenzhe Xu and Yingke Xue and Yang Chen and Ruixu Yang and Shuwei Liu and Yi Liu and Hao Zhang}, doi = {10.1002/advs.202503164}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03164}, shortjournal = {Adv. Sci.}, title = {Manipulating liquid-liquid interphase solute diffusion for the construction of non-symmetric metal-quinone network nanoarchitectonics and nano-motorization}, volume = {12}, year = {2025}, }
• (2025). The multitarget compound ZLY032 achieves treatment of chronic wounds. ADVS, 12(37), e03098. (www)

  @article{ , abstract = {The approach to dealing with chronic wounds is still challenging in clinic. Multitarget drugs have the advantages of superior therapeutic effect and minimal adverse reactions. The aim of the present study is to develop a multitarget treatment strategy for skin wound healing. It is showed here that topical application of ZLY032, a dual free fatty acid receptor 1 (FFA1)/peroxisome proliferator-activated receptor (PPARδ) agonist, accelerates the healing of full-thickness skin wounds in both normal mice and rabbits, even in the diabetic mice and methicillin-resistant Staphylococcus aureus (MRSA) infected mice. At the eukaryotic cell level, ZLY032 shows the ability to accelerate angiogenesis and inhibit inflammation via targeting PPARδ and FFA1. At the prokaryotic cell level, ZLY032 exhibits antibacterial activity against Staphylococcus aureus and MRSA via targeting argininosuccinate lyase (ASAL, argH ). At the application level, ZLY032-loaded microneedles demonstrate a therapeutic effect on wound healing in rabbits with an improved dosing frequency. In this work, ZLY032 application is verified as a potential multitarget strategy for wound healing with good safety and efficacy. Furthermore, the discovery of the antimicrobial target of ZLY032 provides a theoretical basis for the development of novel antibiotics against drug-resistant strains.}, archive = {J_ADVS}, author = {Manyu Gong and Zhiyuan Du and Tiantian Gong and Yu Wang and Chenchen Yin and Bosi Sun and Zijia Liu and Lianru Chen and Zibin Liao and Wenxin Wang and Tianjiao Zhao and Yifei Wang and Ying Dong and Kexin Wang and Mengru Ma and Weijun Li and Jiacheng Li and Haodong Li and Congcong Lin and Ying Zhang and Yu Liu and Xin Liu and Tao Ban and Hongxia Bao and Yang Zhang and Zheng Li and Lei Jiao}, doi = {10.1002/advs.202503098}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03098}, shortjournal = {Adv. Sci.}, title = {The multitarget compound ZLY032 achieves treatment of chronic wounds}, volume = {12}, year = {2025}, }
• (2025). Parvalbumin interneuron-dependent hippocampal neurogenesis evoked by prolonged rhythmic light flicker. ADVS, 12(37), e03017. (www)

  @article{ , abstract = {Rhythmic light flicker alleviates cognitive impairments in various animal models of neurological diseases. However, its long-term effects and underlying mechanisms remain unclear. Here, a cohort of adult mice is subjected to long-term exposure to 40 Hz light flicker (1 hour daily for 30 days) and observed significant enhancements in hippocampal neurogenesis and spatial learning without any adverse behavioral effects. Specific ablation of hippocampal newborn neurons using DCX DTR mice abolished these effects. Furthermore, the inactivation or elimination of GABAergic parvalbumin (PV) interneurons not only impaired 40 Hz light flicker entrainment but also reduce neurogenesis in the dentate gyrus (DG). Long-term flicker exposure increases excitatory input to DG PV interneurons, which enhances PV interneuron excitability, elevated GABA levels, and strengthened inhibitory transmission to newborn neurons, thereby promoting better integration of new neurons into the DG. Blocking GABA A receptors reverse the light flicker-induced increase in neurogenesis and spatial learning. Prolonged flicker exposure do not affect DG regional cerebral blood flow or the activity of excitatory cholinergic, vasoactive intestinal peptide (VIP), or cholecystokinin (CCK) interneurons. These findings suggest that long-term light flicker enhances spatial learning through PV-dependent neurogenesis, with elevated GABAergic activity supporting the development and integration of immature neurons in the adult DG.}, archive = {J_ADVS}, author = {Hai Yan and Yunxuan Wang and Xufan Deng and Shiyu Wu and Yifan Pan and Jun Du and Mei Yu and Bo Liu and Huimei Wang and Zhengyu Zhang and Jinghong Chen and Shuifa Chen and Yizheng Wang and Tara Walker and Perry Bartlett and Jun Ju and Sheng-Tao Hou}, doi = {10.1002/advs.202503017}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e03017}, shortjournal = {Adv. Sci.}, title = {Parvalbumin interneuron-dependent hippocampal neurogenesis evoked by prolonged rhythmic light flicker}, volume = {12}, year = {2025}, }
• (2025). Boosts in polarization and piezoelectric responses of lead-free ferroelectrics through strain-enhanced glassy coexistent polars with high dynamics. ADVS, 12(37), e02973. (www)

  @article{ , abstract = {The miniaturization of domain size via point-defect modification has emerged as an effective strategy for optimizing piezoelectric properties in lead-free ferroelectrics, such as achieving large piezoelectric constants and slim-hysteresis electrostrain through polymorphic nanodomain design. However, this approach is not consistently reliable due to the uncontrollable deceleration of domain wall motion and polarization rotation (i.e., polar dynamics) caused by the random local fields around doping sites. In this work, an innovative strategy is proposed to enhance the polarization and electrostrain responses of nanodomain-patterned ferroelectrics through the design of a strain-enhanced glassy coexistent polar state (SGP), which can be established by incorporating large-radius cation Hf 4+ into (Ba 0.84 Ca 0.16 ) 0.985 Bi 0.01 (Ti 0.9 Zr 0.07 Sn 0.03 )O 3 compositions. The strain-enhanced crossover state between the neighboring glassy tetragonal and orthorhombic domains greatly facilitates overall polar dynamics. This is evidenced by the large dielectric figure of merit ε r /tan δ ≈ 9.9×10 5 with thermal stability up to 23 K, surpassing most of reported lead-free ferroelectric ceramics. Importantly, compared to the initial matrix, significant improvements of 20.8% and 34.2% in maximum polarization and electrostrain amplitude are achieved, while maintaining a minimal polarization/strain hysteresis (≈5%). This work would pave a novel paradigm for designing superior functional ferroics by optimizing the domain dynamics.}, archive = {J_ADVS}, author = {Liqiang He and Le Zhang and Yating Ran and Zibin Chen and Chuanxin Liang and Yanshuang Hao and Jianwei Li and Zhizhi Xu and Sen Yang and Michael A. Carpenter and Xiaobing Ren and Dong Wang}, doi = {10.1002/advs.202502973}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e02973}, shortjournal = {Adv. Sci.}, title = {Boosts in polarization and piezoelectric responses of lead-free ferroelectrics through strain-enhanced glassy coexistent polars with high dynamics}, volume = {12}, year = {2025}, }
• (2025). Advanced cancer immunotherapy via SMARCAL1 blockade using a glucose-responsive CRISPR nanovaccine. ADVS, 12(37), e02929. (www)

  @article{ , abstract = {Cancer immunotherapy that activates the stimulator of interferon genes (STING) signaling pathway to resist tumors has recently attracted considerable attention. However, STING activation can induce opposing interferon functions that contribute to T-cell exhaustion via programmed death-ligand 1 (PD-L1). In particular, effectively using the immune system to combat tumors remains a substantial challenge due to tumor immunosuppressive factors such as SMARCAL1. Here, a glucose-responsive CRISPR nanovaccine is developed for enhancing STING signaling while inhibiting interferon-mediated immunosuppressive feedback. The formulation encapsulates a bimetallic zeolitic imidazolate framework with glucose oxidase (GOx) and CRISPR-mediated SMARCAL1 gene-editing plasmids. The dual enzyme-driven cascade reactions of peroxidase and GOx generate reactive oxygen species (ROS) and gluconic acid, which release and activate the genome-editing system. The silencing of SMARCAL1 enhances STING activity and inhibits PD-L1 expression, resulting in the termination of PD-L1-mediated opposing functions of interferon. Zinc ions and double-stranded DNA formed via ROS further activate the STING pathway, effectively inducing dendritic cell maturation and immune system activation. This is a critical report of in situ CRISPR nanovaccination driven by dual enzymes. The work highlights the potential of glucose-responsive CRISPR nanovaccination in bolstering antitumor immunity and extends the implementation of gene editing in cancer immunotherapy.}, archive = {J_ADVS}, author = {Yuwei Li and Yuanyi Zhang and Chenchen Li and Guoping Chen and Pir Muhammad and Yonghong Yao and Lifang Gao and Zhigang Liu and Yanli Wang}, doi = {10.1002/advs.202502929}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e02929}, shortjournal = {Adv. Sci.}, title = {Advanced cancer immunotherapy via SMARCAL1 blockade using a glucose-responsive CRISPR nanovaccine}, volume = {12}, year = {2025}, }
• (2025). Comprehensive insights into tracheoesophageal fistula pathophysiology, diagnosis, treatment, and future directions. ADVS, 12(37), e02825. (www)

  @article{ , abstract = {Tracheoesophageal fistula (TEF) represents a pathological connection between the trachea and esophagus, classified into congenital and acquired categories. Congenital TEF arises from embryological malformations, often coexisting with esophageal atresia (EA), while acquired TEF primarily stems from malignancies, radiotherapy, or trauma. This condition disrupts normal anatomical functions, leading to significant clinical issues, such as aspiration, respiratory infections, and malnutrition. The current review consolidates findings on the etiology, classification, and pathological mechanisms of TEF, emphasizing how genetic, developmental, and external factors shape its occurrence and progression. Diagnostic advancements, including radiological imaging, endoscopic evaluations, and newer monitoring techniques, have refined clinical assessment. Treatment paradigms for TEF vary from minimally invasive endoscopic interventions, to traditional open and innovative surgical approaches. Conservative management, such as nutritional and anti-infective therapies, remains vital, especially for milder cases. Emerging therapies in regenerative medicine—such as tissue-engineered scaffolds and platelet-rich plasmaoffer transformative potential for refractory cases. Future advancements are oriented toward exploring 3D printing, artificial intelligence, and precision medicine. The necessity of multidisciplinary collaboration is underscored in optimizing holistic patient care. While significant progress has improved cure rates and long-term outcomes, continued research on innovative technologies and clinical trials addressing knowledge gaps in long-term efficacy remains crucial.}, archive = {J_ADVS}, author = {Gang Li and Zhe Wang and Jia Liu and Shenbo Fu and Longmei Xue and Zijun Liao and Rong Yang and Shanping Huang and Rui Xu and Peng Chen and Yong Chen}, doi = {10.1002/advs.202502825}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e02825}, shortjournal = {Adv. Sci.}, title = {Comprehensive insights into tracheoesophageal fistula pathophysiology, diagnosis, treatment, and future directions}, volume = {12}, year = {2025}, }
• (2025). Tunneling nanotube-mediated transcellular autophagy alleviates cadmium induced hepatocyte injury. ADVS, 12(37), e02793. (www)

  @article{ , abstract = {Cadmium (Cd) exposure is strongly linked to various diseases and dysregulation of autophagy is a pivotal mechanism in Cd toxicity. Targeted autophagy strategies are promising for the treatment of autophagy dysregulation-related diseases, including Cd poisoning. However, the current understanding of autophagy mechanisms remains limited, hindering the development of effective strategies. Herein, a novel autophagy pathway, transcellular autophagy. Cd triggers this process in hepatocytes, facilitating the transfer of autophagosomes from damaged to healthy cells for degradation. Mechanistically, reactive oxygen species accumulation is a key driver of transcellular autophagy activation, while the disruption of autophagy fusion mechanisms triggers its activation. Notably, Cd-induced transcellular autophagy relies on the tumor necrosis factor, alpha-induced protein 2 (TNFAIP2)-tunneling nanotube (TNT) system. Blocking this system prevents autophagosome transfer and exacerbates Cd-induced autophagosome overload and apoptosis. The findings offer a novel perspective on autophagy, and provide new insights for targeted autophagy strategies to treat Cd poisoning and autophagy dysregulation-related diseases.}, archive = {J_ADVS}, author = {Tao Wang and Li Wang and Jian Sun and Yan Chen and Waseem Ali and Yonggang Ma and Ruilong Song and Xishuai Tong and Jiaqiao Zhu and Yan Yuan and Jianhong Gu and Jianchun Bian and Zongping Liu and Hui Zou}, doi = {10.1002/advs.202502793}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e02793}, shortjournal = {Adv. Sci.}, title = {Tunneling nanotube-mediated transcellular autophagy alleviates cadmium induced hepatocyte injury}, volume = {12}, year = {2025}, }
• (2025). Epigenetic regulation of DAPK1 and netrin-1 drives diabetic encephalopathy. ADVS, 12(37), e02535. (www)

  @article{ , abstract = {Diabetic encephalopathy (DE) is a severe complication of diabetes characterized by cognitive impairment and synaptic dysfunction, while the underlying mechanisms are not clear. Here, a critical role is identified for death-associated protein kinase 1 (DAPK1) in DE pathogenesis using transgenic and streptozotocin-induced diabetic mouse models. Elevated DAPK1 expression in hippocampal excitatory neurons correlates with cognitive deficits, increases neuronal apoptosis, and disrupts synaptic plasticity. Conditional knockout of DAPK1 in CaMKII-positive neurons significantly mitigates these pathological features, improving cognitive performance and synaptic function. Mechanistically, it is demonstrated that reduced hippocampal microRNA (miR)-216a-5p levels in diabetic mice lead to DAPK1 upregulation. Furthermore, DAPK1 suppresses the expression of the neurotrophic factor Netrin-1 (Ntn1) by phosphorylating hepatocyte nuclear factor 1 homeobox A (HNF1A), a key transcription factor. Silencing Ntn1 in wild-type mice induces DE-like symptoms, while intranasal administration of recombinant Ntn1 restores cognitive function and synaptic integrity in diabetic mice. These findings establish an miR-216a-5p/DAPK1/Ntn1 signaling axis as a critical driver of diabetes-induced cognitive dysfunction and suggest Ntn1 as a promising therapeutic target for DE. Here novel insights into the molecular mechanisms are provided underlying DE, and the therapeutic potential of targeting DAPK1 and Ntn1 is highlighted to alleviate diabetes-associated central nervous system complications.}, archive = {J_ADVS}, author = {Yang Zhou and Jia-Xin Kou and Kai Zheng and Zi-Xuan Guo and Hong-Wei Fan and Wen-Lian Li and Lu-Lu Chu and Jing-Wen Yin and Li-Jie Liu and Nadezhda Brazhe and Zhi-Gao Xiang and Feng Hu and Kai Shu and Ling-Qiang Zhu and Dan Liu}, doi = {10.1002/advs.202502535}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e02535}, shortjournal = {Adv. Sci.}, title = {Epigenetic regulation of DAPK1 and netrin-1 drives diabetic encephalopathy}, volume = {12}, year = {2025}, }
• (2025). PFKFB2-driven glycolysis promotes dendritic cell maturation and exacerbates acute lung injury. ADVS, 12(37), e02428. (www)

  @article{ , abstract = {Acute lung injury (ALI) is a life-threatening condition with excessive immune activation and dysregulated inflammation. Dendritic cells (DCs) play a pivotal role in immune regulation; however, their exact contribution to ALI pathogenesis remains unclear. This study demonstrates that the upregulation of the glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) by hypoxia-inducible factor-1α (HIF-1α) enhances glycolysis, drives DC maturation, and exacerbates inflammation, contributing to the pathogenesis of ALI. The findings reveal that HIF-1α directly binds to the PFKFB2 promoter and drives its transcription, leading to increased glycolysis, accelerated DC maturation, and amplified immune activation. In paraquat (PQ)-ALI and lipopolysaccharide (LPS)-ALI mouse models, DC-specific PFKFB2 knockout and DC-targeted delivery of HIF-1α inhibitor-loaded nanoparticles each significantly suppressed DC maturation and alleviated ALI severity. Analyses of lung tissues from patients with PQ poisoning, secondary bacterial pneumonia (2°BP), and Coronavirus Disease 2019 (COVID-19), as well as from normal controls, confirmed these findings, showing increased PFKFB2 expression and DC maturation during ALI. These findings highlight the HIF-1α–PFKFB2 signaling pathway as a critical regulator of glycolysis-driven DC maturation and immune activation, offering novel insights into immunometabolic regulation and a promising therapeutic target for ALI.}, archive = {J_ADVS}, author = {Ding Yuan and Fang Yang and Linlin Hou and Yan Zhang and Xin Pang and Yuqi Du and Hongyi Yan and Huanzhou Zhu and Yue Cheng and Yue Wu and Pinpin Jiang and Mengnan Guo and Mengying Zhang and Jinjie Guo and Huihui Hao and Yong Jiang and Yi Li and Yanxia Gao}, doi = {10.1002/advs.202502428}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e02428}, shortjournal = {Adv. Sci.}, title = {PFKFB2-driven glycolysis promotes dendritic cell maturation and exacerbates acute lung injury}, volume = {12}, year = {2025}, }
• (2025). ATF3 deficiency exacerbates ageing-induced atherosclerosis and clinical intervention strategy. ADVS, 12(37), e02249. (www)

  @article{ , abstract = {Vascular smooth muscle cell (VSMC) senescence is a pivotal driver of atherosclerosis (AS), but molecular links to ageing-related dysfunction are unclear. It is aimed to identify regulators of VSMC senescence and develop clinical interventions for ageing-related AS. Using single-cell RNA sequencing of human atherosclerotic carotid arteries and immunofluorescence validation, activating transcription factor 3 (ATF3) is identified as central to VSMC senescence. Mechanistic studies employ SMC-specific ATF3 knockout mice, CUT&Tag-seq, RNA/protein interaction assays, and m6A epitranscriptomic analyses. To bridge discovery to therapy, high-throughput virtual screening is performed for ATF3-targeting compounds and functionally validated hits. ATF3 deficiency in VSMCs accelerates ageing-induced AS by promoting senescence. Multi-omics showed ATF3 activates ATG7, triggering autophagy, while cytoplasmic ATG7 enhances ATF3 nuclear translocation, establishing a positive feedback loop. Ageing increases m6A methylation and decreases the stability of Atf3 mRNA. Terazosin (TZ) diminishes the interaction between YTH N6-methyladenosine RNA binding protein F2 (YTHDF2) and Atf3 mRNA, helping to preserve Atf3 mRNA stability. TZ is a promising therapeutic strategy for delaying VSMC senescence and preventing AS. ATF3 protects against VSMC senescence and AS by orchestrating autophagy via a novel ATF3-ATG7 amplification loop. Repurposing TZ to stabilize ATF3 offers a translatable approach to combat ageing-driven cardiovascular disease.}, archive = {J_ADVS}, author = {Hao Nie and Tianyi Ji and Zixin Wan and Jie Huang and Han Li and Lingjiao Zou and Zhen Yang and Jiarui Li and Yuqi Guan and Lei Ruan and Jinhua Yan and Cuntai Zhang}, doi = {10.1002/advs.202502249}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e02249}, shortjournal = {Adv. Sci.}, title = {ATF3 deficiency exacerbates ageing-induced atherosclerosis and clinical intervention strategy}, volume = {12}, year = {2025}, }
• (2025). Cardiovascular disease meets cancer: Exploring the epidemiology in china and homotherapy targeting intersectional mechanisms. ADVS, 12(37), e01820. (www)

  @article{ , abstract = {Cardiovascular disease (CVD) and cancer currently rank among the leading causes of mortality worldwide. Epidemiological studies reveal considerable overlap between CVD and cancer populations, posing challenges in the development of common clinical interventions. This review integrates global perspectives on the shared burden of CVD and cancer, with a focused analysis of regional and demographic disparities within China, as well as significant geographic and lifestyle diversity. This review explores preventive and therapeutic strategies by examining shared risk factors and intersectional mechanisms. First, as the easiest and most effective way, lifestyle modifications that benefit both CVD and cancer are summarized, including physical activity, diet modification, sleep pattern changes, and a reduction in tobacco and alcohol use. Key mechanistic intersections between CVD and cancer, such as metabolic regulation, immune-inflammation, and gut microbes, are discussed to extrapolate prospective homotherapy. Furthermore, the current status and challenges in various promising homotherapy for heteropathy between CVD and cancer are highlighted, especially emphasizing the use of conventional and newly developed CVD medications that may also confer benefits in cancer prevention or treatments. By bridging global trends with China-specific insights, this review aims to advance more precise and equitable prevention and treatments, ultimately reducing the combined burden of these two interconnected diseases.}, archive = {J_ADVS}, author = {Shihan Xiang and Yujie Shan and Shihong Xu and Jing Wang and Meng Luo and Jiaojiao Zhou and Qishan Chen}, doi = {10.1002/advs.202501820}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01820}, shortjournal = {Adv. Sci.}, title = {Cardiovascular disease meets cancer: Exploring the epidemiology in china and homotherapy targeting intersectional mechanisms}, volume = {12}, year = {2025}, }
• (2025). The TET3/GATA6 axis drives lipid metabolism and therapeutic vulnerabilities in pancreatic ductal adenocarcinoma. ADVS, 12(37), e01774. (www)

  @article{ , abstract = {Metabolic reprogramming is a hallmark of cancer, with dysregulated lipid metabolism contributing to tumor progression and therapy resistance. This study identifies the DNA demethylase TET3 as a key regulator of lipogenic metabolism in pancreatic ductal adenocarcinoma (PDAC). TET3 expression is elevated in the lipogenic PDAC subtype and correlates with poor patient prognosis. Genetic ablation of TET3 disrupts lipid homeostasis, alters the saturated-to-monounsaturated fatty acid ratio, and reduces proliferative capacity. Mechanistically, TET3 represses GATA6 expression through recruitment of histone deacetylases (HDACs) to its promoter, leading to H3K27 deacetylation, independent of its catalytic activity. Loss of TET3 derepresses GATA6 , which in turn suppresses lipogenic enzymes, such as stearoyl-CoA desaturase ( SCD ) and acyl-CoA synthetase long-chain family member 3 ( ACSL3 ), and sensitizes cells to ferroptosis. Notably, combined treatment with the HDAC inhibitor SAHA and the ferroptosis inducer Erastin significantly enhances gemcitabine-induced cytotoxicity in lipogenic PDAC cells. These findings uncover a previously unrecognized non-catalytic function of TET3 in sustaining lipid metabolic reprogramming in PDAC. Targeting the TET3/GATA6 axis in combination with ferroptosis and epigenetic modulators offers a promising strategy to overcome therapeutic resistance in aggressive pancreatic cancer.}, archive = {J_ADVS}, author = {Shuai Liu and Shaobo Kang and Na Lin and Wenqi Zhang and Shiwen Wang and Yuqing Ren and Xiaofan Ding and Jianxiu Yu and Ruiyu Xie}, doi = {10.1002/advs.202501774}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01774}, shortjournal = {Adv. Sci.}, title = {The TET3/GATA6 axis drives lipid metabolism and therapeutic vulnerabilities in pancreatic ductal adenocarcinoma}, volume = {12}, year = {2025}, }
• (2025). Human schlafen 14 cleavage of short double-stranded RNAs underpins its antiviral activity. ADVS, 12(37), e01727. (www)

  @article{ , abstract = {The Schlafen (SLFN) genes are induced by interferons, underscoring their roles in the immune response and viral replication inhibition. SLFN14, a member of SLFN family, is associated with multiple human diseases; however, neither its functions nor its disease mechanisms are fully understood. Herein, human SLFN14 biochemically is characterized, demonstrating that it specifically cleaves RNAs containing short duplex regions, such as hairpin RNAs and tRNAs, but does not have ATPase or helicase activity. Cryogenic electron microscopy structures of SLFN14 apoenzyme (2.84 Å) and SLFN14-hairpin RNA complex (2.88 Å) are determined, revealing that SLFN14 assembles into a ring-like dimer and dimerization is mainly mediated by hydrophobic contacts. Two N-terminal RNase domains of SLFN14 are organized head-to-tail, forming an RNA-binding groove that can accommodate a 12-bp hairpin RNA. The hairpin RNA is recognized mainly through phosphate backbone interactions. Further, SLFN14 is shown to inhibits HIV-1 pseudovirus replication. The anti-HIV-1 activity of SLFN14 is via codon-usage-dependent translational inhibition and impairment of the programmed -1 ribosomal frameshifting, with an efficiency comparable to that of Shiftless. Using tRNA PCR arrays, SLFN14 and SLFN11 are found to decrease both nuclear-encoded and mitochondrial tRNAs in cells. Together, these results provide novel insights into the function of SLFN14 and its role in HIV-1 restriction.}, archive = {J_ADVS}, author = {Mengyun Li and Dapeng Sun and Wei Hao and Hua Fu and Yueli Zhang and Zhijian Li and Bo Qin and Yumei Wang and Sheng Cui}, doi = {10.1002/advs.202501727}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01727}, shortjournal = {Adv. Sci.}, title = {Human schlafen 14 cleavage of short double-stranded RNAs underpins its antiviral activity}, volume = {12}, year = {2025}, }
• (2025). Aligned conductive magnetic nanofibers with directional magnetic field stimulation promotes peripheral nerve regeneration. ADVS, 12(37), e01665. (www)

  @article{ , abstract = {Peripheral nerve injury is one of the most common disorders of the nervous system. Alternatives to autologous nerve transplantation have attracted significant interest among researchers. In this study, magnetic nanoparticles are integrated with oriented polycaprolactone (PCL) fibers, followed by the addition of a polypyrrole (Ppy) coating. Ppy-PCL/Fe 3 O 4 , when combined with a static magnetic field, activates the superparamagnetic properties of the nanoparticles while ensuring conductivity, creating an environment conducive to nerve regeneration. The optimal intensity of the external magnetic field stimulation is assessed in vitro, and its effects on calcium influx and differentiation in rat RSC96 and PC12 cells, respectively, are examined. The superior efficacy of the integrated system in nerve regeneration is confirmed by histological and functional analyses in vivo. Exploration of the underlying molecular pathways using transcriptome sequencing shows that the regenerative system promotes the release of brain-derived neurotrophic factor and reduces the production of reactive oxygen species. This comprehensive approach not only demonstrates the efficacy of the system in promoting peripheral nerve regeneration but also lays the groundwork for elucidating the underlying mechanistic pathways involved.}, archive = {J_ADVS}, author = {Zheyuan Fan and Wei Yu and Xinggui Wen and Xiangdong Ding and Xiang Li}, doi = {10.1002/advs.202501665}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01665}, shortjournal = {Adv. Sci.}, title = {Aligned conductive magnetic nanofibers with directional magnetic field stimulation promotes peripheral nerve regeneration}, volume = {12}, year = {2025}, }
• (2025). Boosting organic long persistent luminescence by enhancing charge separation processes in three-component systems. ADVS, 12(37), e01558. (www)

  @article{ , abstract = {Organic long persistent luminescence (OLPL) materials feature power law emission decay and minutes-/hours-long afterglow durations because of retarded charge recombination. Unlike conventional room-temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) afterglow, the emergence of OLPL must include a charge separation process in its photophysical mechanism; consequently, the reported OLPL examples are much fewer than conventional afterglow materials. The incorporation of an electron donor or acceptor is conceived to interact with the long-lived excited state in conventional afterglow system, aiming to induce charge separation. Here, the study first builds two-component RTP/TADF afterglow systems composed of difluoroboron β-diketonate (BF 2 bdk) dopants and organic crystalline matrices, and then introduces an electron-donating component into the two-component BF 2 bdk-matrix systems to enable the charge separation processes. The resultant three-component materials exhibit visible-light-excitable OLPL afterglow lasting for several hours under ambient condition. Leveraging the efficient harvesting of singlet/triplet excitons by BF 2 bdk and the protective environment provided by the crystalline matrix, the three-component materials exhibit an estimated OLPL efficiency of ≈10% and display OLPL brightness comparable to inorganic Sr 2 Al 14 O 25 /Eu 2+ , Dy 3+ materials. Furthermore, the obtained OLPL materials show promising applications in afterglow displays and information storage, marking a significant step toward practical implementations of organic afterglow materials.}, archive = {J_ADVS}, author = {Zi Ye and Wen Xia and Guangming Wang and Guoyi Wu and Hongxin Gao and Biao Xu and Kaka Zhang}, doi = {10.1002/advs.202501558}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01558}, shortjournal = {Adv. Sci.}, title = {Boosting organic long persistent luminescence by enhancing charge separation processes in three-component systems}, volume = {12}, year = {2025}, }
• (2025). Human nervous system-based biohybrid robot-on-A-chip with sensing function for toxicity screening. ADVS, 12(37), e01452. (www)

  @article{ , abstract = {Biohybrid robots and biohybrid robot-on-a-chip have been developed for drug screening and toxicity screening the complementing animal experiments. A sensing system is needed to evaluate the response to external stimulation, but until now, only the human motor system-based biohybrid robot-on-a-chip with neuromuscular system has been developed without a sensing system. A human nervous system-based biohybrid robot-on-a-chip with eye function as a sensing system in addition to brain/motor neuron/muscle functions is proposed for the first time. Eye assembloid is fabricated by a combination of thalamic organoid covered with Au nanomesh and four retinal organoids. By a combination of eye assembloid, cerebral organoid, motor neuron spheroid, and muscle bundle on polymer substrate, a human nervous system-based biohybrid robot-on-a-chip is made. When blue light is used to cause retinal damage or a hydroxychloroquine (HCQ), a retinal toxic chemical, is applied to the eye assembloid, they caused a decrease in muscle bundle contraction. These results indicated that electrophysiological signals generated by the eye assembloid are transmitted to the muscle bundle through cerebral organoid and motor neuron spheroids, and thus the proposed system can perform the toxicity screening. Human nervous system-based biohybrid robot-on-a-chip can be applied to drug screening of neurodegenerative diseases and toxicity screening for the complement of animal experiments in the future.}, archive = {J_ADVS}, author = {Minkyu Shin and Joungpyo Lim and Seewoo Kim and Sangeun Lee and Wei Wen Su and Jinho Yoon and Jeong-Woo Choi}, doi = {10.1002/advs.202501452}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01452}, shortjournal = {Adv. Sci.}, title = {Human nervous system-based biohybrid robot-on-A-chip with sensing function for toxicity screening}, volume = {12}, year = {2025}, }
• (2025). MALMPS: A machine learning-based metabolic gene prognostic signature for stratifying clinical outcomes and molecular heterogeneity in stage II/III colorectal cancer. ADVS, 12(37), e01333. (www)

  @article{ , abstract = {Colorectal cancer (CRC) is a frequently lethal disease, with stage II/III CRC accounting for ≈70%. Metabolic reprogramming plays a pivotal role in deciphering cancer heterogeneity and progression. Here, 9 datasets and 83 machine learning algorithm combinations are leveraged‌ to develop the Machine Learning-based Metabolic gene Prognostic Signature (MALMPS) model. The MALMPS model outperformed traditional clinical traits and molecular features in predicting prognosis for stage II/III CRC patients across training and validation datasets. COX7B, a key gene in MALMPS, is shown to promote CRC malignancy through multi-omics analysis and in vitro assays. CRC patients are stratified into high- and low-risk groups based on the median cutoff of MALMPS. Notably, the high-risk subgroup exhibited poor prognosis, activated inflammation, and enriched carbohydrate, glycosaminoglycan, and lipid metabolism, with therapeutic potential for IGF-1R and Wnt/β-catenin inhibitor. In contrast, the low-risk group displayed a TGF-β pathway inactivating mutation and enriched in nucleotides, cofactors, and amino acids metabolism. Metabolite profiling in the in-house SDCRC dataset validated the distinct metabolic alterations between the two groups. These findings indicate that MALMPS is a valuable instrument for predicting the recurrence risk of stage II/III colorectal cancer, particularly for identifying individuals at high risk.}, archive = {J_ADVS}, author = {Hao Chen and Ze Wang and Chenglong Sun and Yang Zhong and Yuan Liu and Yikun Li and Tongchao Zhang and Yuan Zhang and Xingyu Zhu and Leping Li and Feifei Teng and Ming Lu and Wei Chong}, doi = {10.1002/advs.202501333}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01333}, shortjournal = {Adv. Sci.}, title = {MALMPS: A machine learning-based metabolic gene prognostic signature for stratifying clinical outcomes and molecular heterogeneity in stage II/III colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Gamma-glutamyl cysteine ligase activity as a proxy for human t cell function and drug-induced immunosuppression. ADVS, 12(37), e01179. (www)

  @article{ , abstract = {T cell effector functions are critical for immune defense, but their dysregulation can cause diseases like immune exhaustion in cancer and loss of tolerance in autoimmunity. Curtailing these functions is essential in therapies such as chimeric antigen receptor T-cell (CAR-T) therapies or organ transplantation to avoid hyperactivation and rejection. A major challenge in the field is the precise, live measurement of T cell function at the single-cell level, limiting the prediction of immune responses, the development of effective immunotherapies, and optimization of immunosuppressive regimens. Gamma-Glutamyl Cysteine Ligase (GCL), the rate-limiting enzyme in glutathione (GSH) synthesis, is essential for T cell function in mice, but its role in human T cells is underexplored. GLed , a novel reversible lanthanide-based GSH sensor is introduced that enables real-time, quantitative measurements of GCL activity at single-cell resolution. The GLed approach distinguishes GSH contributions from GCL and GSR, linking GCL activity directly to human T cell effector functions. Additionally, this reveals previously unknown modulation of GCL activity by immunosuppressive drugs, underscoring GCL as a critical player in T cell function and a potential therapeutic target in immune-related diseases.}, archive = {J_ADVS}, author = {Francisco Fueyo-González and Carmen Salto-Giron and Mehek Ningoo and Laura Espinar-Barranco and Rafael Salto and Jose Manuel Paredes and Rosario Herranz and Angel Orte and Miguel Fribourg and Juan A. González-Vera}, doi = {10.1002/advs.202501179}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01179}, shortjournal = {Adv. Sci.}, title = {Gamma-glutamyl cysteine ligase activity as a proxy for human t cell function and drug-induced immunosuppression}, volume = {12}, year = {2025}, }
• (2025). Cytokine storm induction linked to multi-organ failure in fatal jellyfish stings. ADVS, 12(37), e01104. (www)

  @article{ , abstract = {Fatal jellyfish stings often cause multi-organ failure. Until now, these fatal outcomes are attributed to the direct toxic effects of the venom. Here, a mouse model of delayed jellyfish envenomation syndrome (DJES) is established and showed that venom from Nemopilema nomurai jellyfish can trigger a deadly cytokine storm – a severe inflammatory reaction. Mice injected with the venom displayed acute multi-organ failure and significant upregulation of over 20 pro-inflammatory cytokines (including IL-6, TNF-α, CXCL2, and CCL4) in the heart, liver, and kidneys. Transcriptomic analyses identified NF-κB p65 subunit activation as central to the cytokine storm induction. Knockdown of p65 in macrophages reduced cytokine production and improved cell viability. Treatment with dexamethasone, an NF-κB inhibitor, effectively suppressed the cytokine storm, mitigated organ damage, and increased survival rates in mice. The findings present new insights to treat fatal jellyfish stings.}, archive = {J_ADVS}, author = {Yichao Wang and Yi Wang and Fengling Yang and Jingbo Chen and Xiaoyu Geng and Qing Sun and Jinyu Zhang and Chang Liu and Jie Lv and Xiaochuan Hou and Yongfang Wang and Huiyan Lin and Jing Zhang and Lingxin Chen and Bing Yan and Liang Xiao}, doi = {10.1002/advs.202501104}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01104}, shortjournal = {Adv. Sci.}, title = {Cytokine storm induction linked to multi-organ failure in fatal jellyfish stings}, volume = {12}, year = {2025}, }
• (2025). Topological scaffold-based trispecific recombinant protein-drug conjugates for solid tumor eradication. ADVS, 12(37), e01093. (www)

  @article{ , abstract = {Topology structure of proteins plays vital roles on their bioactivity and property. However, the understanding of how the biological effect of active targeting groups varies with different spatial positions in the recombinant protein scaffold is poor. Here a three trispecific recombinant heterotrimeric proteins and their drug conjugates are reported with a star and linear topology structure prepared by genetically encoded fusion and SpyTag-SpyCatcher technology, which can simultaneously bind the human epidermal growth factor receptor 1 and 2 as well as integrin α v β 3 on the surface of cancer cells. The biological difference of heterotrimeric proteins with different topologic structures is evaluated. Given the unique topological structure and superior biologic effects, star-shaped trispecific recombinant proteins can specifically deliver the covalently linked payload, 7-ethyl-10-hydroxycamptothecin, into HeLa tumor, leading to complete tumor eradication, while linear structural ones can only control tumor growth to some extent. The remarkable antitumor activity of the designed recombinant protein-drug conjugate with star-shaped structure in both small and large tumor models can be attributed not only to the triple targeting against EGFR, HER2, and integrin α v β 3 , but also to the “site effect” of targeting elements in heterotrimeric fusion proteins brought by the unique topological structure. The results suggest that trispecific heterotrimeric recombinant proteins with a star-shaped topological structure is a promising drug conjugate platform.}, archive = {J_ADVS}, author = {Huiyi Jiang and Yang Yuan and Xiaoke Zhang and Weizhi Chen and Hui Mao and Baorui Liu and Xiqun Jiang}, doi = {10.1002/advs.202501093}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e01093}, shortjournal = {Adv. Sci.}, title = {Topological scaffold-based trispecific recombinant protein-drug conjugates for solid tumor eradication}, volume = {12}, year = {2025}, }
• (2025). PP2Acα deficiency in vascular smooth muscle cells accelerates aortic aneurysm and dissection by regulating KLF4 phosphorylation and ubiquitination. ADVS, 12(37), e00102. (www)

  @article{ , abstract = {Aortic aneurysm and dissection (AAD) are life-threatening cardiovascular diseases with limited effective medical treatments. Protein phosphatase 2A (PP2A), the most abundant serine/threonine phosphatase in eukaryotes, is pivotal in regulating intracellular signaling. This study investigates the role of PP2A in the pathogenesis of AAD. Analysis of available datasets revealed that PP2Acα is the most significantly downregulated PP2A subunit in human and mouse aneurysm tissues. Vascular smooth muscle cell (VSMC)-specific PP2Acα knockout exacerbates β-Aminopropionitrile (BAPN)-induced aortic dissection and elastase-induced abdominal aortic aneurysm in mice. Collagen-based contraction assays, Western blot, and gelatin zymography confirmed that the deficiency of PP2Acα results in decreased contractility, contractile markers, and elevated production of matrix metallopeptidase 2 (MMP2) in VSMCs. Furthermore, PP2Acα deficiency promoted VSMC phenotypic switching through stabilizing Kruppel-like factor 4 (KLF4). Mechanistically, PP2Acα binds to and dephosphorylates protein kinase B 1 (AKT1), thereby reducing phosphorylation of the AKT1 substrate KLF4 at Thr398. The deficiency of PP2Acα diminishes KLF4 phosphorylation-dependent ubiquitination and degradation, leading to the suppression of VSMC contractile gene transcription. The findings underscore a critical role for PP2Acα in regulating VSMC phenotypic switching and AAD progression by controlling KLF4 phosphorylation and ubiquitination, offering novel insights into the molecular pathogenesis underlying AAD.}, archive = {J_ADVS}, author = {Wei-Peng Hu and Ze-Yu Cai and Qing-Le Li and Tao Zhang and Xiang-Yu Chu and Chang Wang and Qing-Yi Zhang and Rong Qi}, doi = {10.1002/advs.202500102}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {e00102}, shortjournal = {Adv. Sci.}, title = {PP2Acα deficiency in vascular smooth muscle cells accelerates aortic aneurysm and dissection by regulating KLF4 phosphorylation and ubiquitination}, volume = {12}, year = {2025}, }
• (2025). Gamma-glutamyl cysteine ligase activity as a proxy for human t cell function and drug-induced immunosuppression (Adv. sci. 37/2025). ADVS, 12(37), 71805. (www)

  @article{ , archive = {J_ADVS}, author = {Francisco Fueyo-González and Carmen Salto-Giron and Mehek Ningoo and Laura Espinar-Barranco and Rafael Salto and Jose Manuel Paredes and Rosario Herranz and Angel Orte and Miguel Fribourg and Juan A. González-Vera}, doi = {10.1002/advs.71805}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {71805}, shortjournal = {Adv. Sci.}, title = {Gamma-glutamyl cysteine ligase activity as a proxy for human t cell function and drug-induced immunosuppression (Adv. sci. 37/2025)}, volume = {12}, year = {2025}, }
• (2025). A near-field coupling array enables parallel imaging and SNR gain in MRI (Adv. sci. 37/2025). ADVS, 12(37), 71804. (www)

  @article{ , archive = {J_ADVS}, author = {Zhiguang Mo and Shao Che and Feng Du and Enhua Xiao and Qiaoyan Chen and Nan Li and Sen Jia and Changjun Tie and Bing Wu and Xiaoliang Zhang and Hairong Zheng and Ye Li}, doi = {10.1002/advs.71804}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {71804}, shortjournal = {Adv. Sci.}, title = {A near-field coupling array enables parallel imaging and SNR gain in MRI (Adv. sci. 37/2025)}, volume = {12}, year = {2025}, }
• (2025). Serrodyne-enabled dual electro-optic comb interferometry for high-precision absolute ranging and integration-ready metrology (Adv. sci. 37/2025). ADVS, 12(37), 71802. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaoyang Guo and Xusheng Yang and Jiawen Zhi and Chenggang Shao and Hanzhong Wu}, doi = {10.1002/advs.71802}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {71802}, shortjournal = {Adv. Sci.}, title = {Serrodyne-enabled dual electro-optic comb interferometry for high-precision absolute ranging and integration-ready metrology (Adv. sci. 37/2025)}, volume = {12}, year = {2025}, }
• (2025). The TET3/GATA6 axis drives lipid metabolism and therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (Adv. sci. 37/2025). ADVS, 12(37), 71801. (www)

  @article{ , archive = {J_ADVS}, author = {Shuai Liu and Shaobo Kang and Na Lin and Wenqi Zhang and Shiwen Wang and Yuqing Ren and Xiaofan Ding and Jianxiu Yu and Ruiyu Xie}, doi = {10.1002/advs.71801}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {71801}, shortjournal = {Adv. Sci.}, title = {The TET3/GATA6 axis drives lipid metabolism and therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (Adv. sci. 37/2025)}, volume = {12}, year = {2025}, }
• (2025). Targeting hyperglycemic bone pre-metastatic niche for breast cancer bone metastasis therapy (Adv. sci. 37/2025). ADVS, 12(37), 71800. (www)

  @article{ , archive = {J_ADVS}, author = {Jianxin Ye and Peng Hu and Rui Zhang and Lei Zhou and Zonghua Luo and Yanan Chen and Shengzhe Ruan and Mengyi Zhu and Huaze Ding and Yike Qian and Yan Xing and Tong Meng and Changping Wang and Dianwen Song}, doi = {10.1002/advs.71800}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {71800}, shortjournal = {Adv. Sci.}, title = {Targeting hyperglycemic bone pre-metastatic niche for breast cancer bone metastasis therapy (Adv. sci. 37/2025)}, volume = {12}, year = {2025}, }
• (2025). BCG-derived outer membrane vesicles induce TLR2-dependent trained immunity to protect against polymicrobial sepsis (Adv. sci. 37/2025). ADVS, 12(37), 71799. (www)

  @article{ , archive = {J_ADVS}, author = {Yuan Gong and Wenyan Hao and Lingqi Xu and Yingyi Yang and Zhenzhen Dong and Peng Pan and Zhenjiang Bai and Jie Huang and Kaidi Yang and Zhu Jin and Rui Kang and Qiang Shan and Jiang huai Wang and Zijian Zhou and Daolin Tang and Jian Wang and Huiting Zhou}, doi = {10.1002/advs.71799}, journal = {Advanced Science}, month = {10}, number = {37}, pages = {71799}, shortjournal = {Adv. Sci.}, title = {BCG-derived outer membrane vesicles induce TLR2-dependent trained immunity to protect against polymicrobial sepsis (Adv. sci. 37/2025)}, volume = {12}, year = {2025}, }
• (2025). Integrated transcriptome and metabolomics analyses show MYC as a potential therapeutic target for behçet's uveitis. ADVS, 12(36), e17843. (www)

  @article{ , abstract = {Behçet's uveitis (BU), characterized by recurrent bilateral panuveitis, is a severe manifestation of Behcet's disease (BD). However, disease-specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and single-cell RNA sequencing (scRNA-seq) are performed in patients with BU and healthy controls (HC). scRNA-seq data of experimental autoimmune uveitis (EAU) mice are also incorporated. The data showed an altered metabolic profile, characterized by upregulated glycolysis in BU. MYC is predicted to be a hub molecule regulating glycolysis and T cell response. Notably, it is discovered that the expression level of MYC is higher in BU compare to HC and may reflect the treatment response of BU disease. Correspondingly, the scRNA-seq data of EAU mice also reveal higher glycolysis levels and MYC expression. Further studies reveal that inhibition of MYC repressed glycolysis and exerted therapeutic effects similar to those of glycolysis inhibitors, including amelioration of EAU and repression of the abnormal response of effector T cells (T helper [Th]-1 and Th17 cells). Mechanically, inhibiting MYC disrupts the glycolysis-PI3K signaling circuit to curb the effector T cell response in uveitis. Collectively, the study indicated that MYC promoted glycolysis to fuel abnormal T-cell responses, thus therapeutically targeting MYC would provide an attractive approach for treating BU.}, archive = {J_ADVS}, author = {He Li and Lei Zhu and Zhaohuai Li and Yihan Zhang and Genxian Zhang and Xuening Peng and Dongting Wu and Qi Jiang and Rong Wang and Renbing Jia and Song Guo Zheng and Wenru Su}, doi = {10.1002/advs.202417843}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e17843}, shortjournal = {Adv. Sci.}, title = {Integrated transcriptome and metabolomics analyses show MYC as a potential therapeutic target for behçet's uveitis}, volume = {12}, year = {2025}, }
• (2025). Tracing and capturing the epiblast pluripotency of sheep preimplantation embryos. ADVS, 12(36), e17764. (www)

  @article{ , abstract = {Capturing different pluripotent state stem cells from epiblast in vitro helps understand embryonic development and provides invaluable cell sources for basic research and regenerative medicine. Sheep are not only one of the most important livestock species in agriculture but also serve as an ideal preclinical model for studying human disease. Single-cell transcriptome analysis of sheep preimplantation embryos from embryonic day (E) 1 to E14 is performed to investigate the pluripotency changes of epiblast and elucidate the pluripotent regulation signaling. By combination of growth factors or inhibitors of JAK/STAT3, FGF, WNT, and TGF-β pathways in the culture medium, sheep formative and primed pluripotent stem cells (sfPSCs and spPSCs) are established respectively. The newly derived PSCs could maintain over 100 passages and differentiate into three germ layers. In addition, sfPSCs and spPSCs exhibit different molecular features, and sfPSCs have the ability of contribution to ICM and can be used as donor cells for producing cloned embryos efficiently. A cross-species comparison of early embryo development in mouse, pig and sheep illustrates the conservation of the epiblast naïve to primed state transition process and the divergence of the developmental events time points, the specific gene expression patterns and pluripotent regulation signaling. These studies are expected to improve our understanding of mammal early embryo development and present a reference for defining pluripotency.}, archive = {J_ADVS}, author = {Jinying Zhang and Runbo Li and Ruijie Luo and Qiang Zhang and Zimo Zhao and Haishen Xu and Minglei Zhi and Wenjie Jiang and Meng Wang and Xinze Chen and Zhiqiang Feng and Yingjie Wang and Yuhan Yang and Pengcheng He and Hanyue Su and Tianzhi Chen and Shunxin Wang and Yixuan Yao and Jinghui Yang and Fan Zhao and Tingting Li and Haitao Wang and Xiaosheng Zhang and Jinlong Zhang and Qiuyue Liu and Shuai Gao and Yuchang Yao and Jianyong Han and Suying Cao}, doi = {10.1002/advs.202417764}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e17764}, shortjournal = {Adv. Sci.}, title = {Tracing and capturing the epiblast pluripotency of sheep preimplantation embryos}, volume = {12}, year = {2025}, }
• (2025). A 3D printing strategy for hard curved surfaced circuits: From materials to applications. ADVS, 12(36), e17648. (www)

  @article{ , abstract = {With the continuous development of digital surface circuit manufacturing technology, the three-dimensional (3D) printing strategy of structural electronics has shown an increasingly wide application prospect in the field of electronics, especially in its main subfields such as conformal antennas, sensors, and aerospace. However, there are still many technical challenges in manufacturing high-precision circuits on complex curved surfaces and within structures. In view of that, this study summarizes the latest development trends and results in 3D printing technology for structural electronics, focusing on the materials, conformal manufacturing technology, printing process control strategies, and their practical applications. In addition, this study analyzes the characteristics, advantages, and limitations of different digital surface circuit manufacturing processes and discusses their application potentials in practice. Finally, this study presents possible future development directions in the field of structural electronics 3D printing and emphasizes the opportunities and challenges in manufacturing conformal electronics on arbitrary surfaces.}, archive = {J_ADVS}, author = {Wang Qin and Shujuan Li and Wei Wei and Haiqing Bai and Shikui Jia and Robert G Landers and Yunlong Ma and Sha Wei and Tuo Kang and Miao Zhang and Weipei Zhang and Mingkun Wang and Tongxin Guan}, doi = {10.1002/advs.202417648}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e17648}, shortjournal = {Adv. Sci.}, title = {A 3D printing strategy for hard curved surfaced circuits: From materials to applications}, volume = {12}, year = {2025}, }
• (2025). A mitochondria-targeted nanozyme platform for multi-pathway tumor therapy via ferroptosis and cuproptosis regulation. ADVS, 12(36), e17616. (www)

  @article{ , abstract = {Transition metal-based nanotherapeutics, such as chemodynamic therapy and ferroptosis- or cuproptosis-induced strategies, hold great potential for cancer treatment. Copper- and iron-based nanozymes enhance reactive oxygen species (ROS) generation and regulate metal ion homeostasis, driving ferroptosis and cuproptosis. However, simultaneous delivery of copper and iron ions and the role of mitochondria-targeted copper in inducing cuproptosis remain underexplored. Here, a dual-functional nano-heterojunction platform, MIL-Cu 1.8 S-TPP/FA, is reproted, integrating iron- and copper-based components for synergistic ferroptosis and cuproptosis induction. Mitochondria-targeted Cu 1.8 S nanodots demonstrated high biocompatibility and efficiently induced cuproptosis by disrupting mitochondrial iron-sulfur proteins. Combined with MIL-88B, the iron-based metal-organic framework, the MIL-Cu 1.8 S heterojunction exhibited enhanced ROS catalytic activity, confirmed by density functional theory (DFT) analysis, with improved H 2 O 2 adsorption and lower energy barriers for peroxidase (POD)-like reactions. The dual-targeting MIL-Cu 1.8 S-TPP/FA nanoplatform effectively delivered copper ions to mitochondria and iron ions to tumor cells, modulating key ferroptosis- and cuproptosis-related markers, such as GPX4, GSH, FDX-1, and HSP70. The platform synergistically combined photothermal effects with multi-pathway cell death mechanisms, achieving significant anti-tumor efficacy in vitro and in vivo. This study underscores the therapeutic potential of synchronously delivering copper and iron ions and highlights mitochondria-targeted strategies in advancing multi-modal cancer therapies.}, archive = {J_ADVS}, author = {Chenguang Liu and Lingxiao Guo and Yuying Cheng and Jingjie Gao and Hanling Pan and Jiayi Zhu and Danting Li and Liqing Jiao and Caiyun Fu}, doi = {10.1002/advs.202417616}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e17616}, shortjournal = {Adv. Sci.}, title = {A mitochondria-targeted nanozyme platform for multi-pathway tumor therapy via ferroptosis and cuproptosis regulation}, volume = {12}, year = {2025}, }
• (2025). Light-driven, super-fast self-healing transparent MXene/W18O49/Polyurethane films with superior toughness for thermal management. ADVS, 12(36), e16805. (www)

  @article{ , abstract = {Light-driven materials have attracted great interest for their promising applications in next-generation smart devices. The incorporation of various photothermal materials into polymers has been developed for endowing composites with the capability of light harvesting and photothermal conversion, and management. However, their opaque appearance, vulnerability, and challenging processability limit their practical applications. Herein, it is successfully synthesized a series of versatile transparent films (PUMW) that combine photothermal self-healing function and mechanical strength through integrating polyurethane (PU) self-healing polymers with plasmonic enhanced MXene and W 18 O 49 hybrids (MXene@W 18 O 49 ). The resulting comprehensive film (PUMW4) maintained a visible-light transmittance of over 79% in 0.2 mm thickness, and could rapidly reach 102 °C within 5 min under light irradiation of 0.45 W cm −2 . Furthermore, it demonstrated a favorable ability for photothermal self-healing, with surface scratches disappearing in 2 min. Besides, the tensile strength of PUMW4 significantly increased from 22.7 to 30.7 MPa, in comparison with PUMW0 (pure PU). The proof of concept for an indoor thermal insulation test demonstrates that the organic glass house model covered with the film exhibited a temperature reduction of 10 °C compared to the naked model, highlighting the potential of as-prepared PUMW films in energy-saving applications for large-scale out-door buildings.}, archive = {J_ADVS}, author = {Xiaoqing Sui and Weijing Yao and Jingyi Chen and Shilong Han and Dai Yang and Jingyang Li and Kaixi Wang and Wenzhuo Wu and Hongxing Pei and Qingyong Tian and Qun Xu}, doi = {10.1002/advs.202416805}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e16805}, shortjournal = {Adv. Sci.}, title = {Light-driven, super-fast self-healing transparent MXene/W18O49/Polyurethane films with superior toughness for thermal management}, volume = {12}, year = {2025}, }
• (2025). Alistipes senegalensis is critically involved in gut barrier repair mediated by panax ginseng neutral polysaccharides in aged mice. ADVS, 12(36), e16427. (www)

  @article{ , abstract = {Ginseng polysaccharides (GPs) are known to have beneficial effects on the gut epithelium and age-related systemic-inflammation through regulation of gut microbiota. However, the underlying pathways and key members of the microbial community involved in this process are poorly understood. In this study, administration of ginseng neutral polysaccharide (GPN) is found to alleviate gut leak and low-grade inflammation, concomitantly with improving the physiological function aged mice. Fecal microbiota transplantation and fecal conditioned medium are used to assess the specific involvement of gut bacterial metabolites in the effects of GPNs. Comprehensive multi-omics analyses showed that GPN significantly enriched the abundance of Alistipes senegalensis , an indole-producing commensal bacterium. Increased expression of tight junction-associated proteins, as well as activation of gut stem cells, are found to be mediated by the AhR pathway, indicating the causal mechanism by which GPN reduced increases in gut permeability. The results are verified in Caco-2/THP-1 cells, Caenorhabditis elegans , and enteroids. To the knowledge, this is the first identification of an integral functional axis through which GPN and functional metabolites of A. senegalensis influence the gut barrier and reduce systemic inflammation, providing clues for the potential development of innovative plant polysaccharide treatment strategies to promote healthy aging.}, archive = {J_ADVS}, author = {Dandan Wang and Hui Wang and Yingna Li and Jing Lu and Xiaolei Tang and Dan Yang and Manying Wang and Daqing Zhao and Fangbing Liu and Shuai Zhang and Liwei Sun}, doi = {10.1002/advs.202416427}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e16427}, shortjournal = {Adv. Sci.}, title = {Alistipes senegalensis is critically involved in gut barrier repair mediated by panax ginseng neutral polysaccharides in aged mice}, volume = {12}, year = {2025}, }
• (2025). The DEC2-SCN2A axis is essential for the anticonvulsant effects of cannabidiol by modulating neuronal plasticity. ADVS, 12(36), e16315. (www)

  @article{ , abstract = {Impairment of neuronal plasticity is involved in a spectrum of neurological disorders such as epilepsy, yet its regulatory mechanisms remain incompletely understood. Here, it is reported that the basic helix-loop-helix transcription factor DEC2 serves as a pivotal regulator of both neuronal plasticity and epileptogenesis through its repression of sodium voltage-gated channel alpha subunit 2 (SCN2A). Knockdown of DEC2 in hippocampal neurons elevates intrinsic excitability and synaptic transmission, exacerbating seizure susceptibility and severity. Conversely, overexpression of DEC2 in hippocampus reduces intrinsic excitability and synaptic transmission, ultimately decreasing seizure susceptibility. Mechanistically, DEC2 functions as a transcriptional repressor of Scn2a by directly binding class B E-boxes (CACGTG) in its promoter. Additionally, DEC2 forms complexes with myoblast determination protein 1 (MYOD1) and occupies the CAGCTG E-boxes within the Scn2a promoter; however, this interaction does not affect Scn2a transcription in vivo. These findings also reveal that cannabidiol (CBD) can modulate the DEC2-SCN2A axis. Notably, CBD predominantly enhances DEC2's direct transcriptional repression of SCN2A. In summary, this study identifies DEC2 as a critical regulator of neuronal plasticity in epilepsy progression, suggesting a novel therapeutic pathway for epilepsy treatment.}, archive = {J_ADVS}, author = {Huifang Song and Yifan Wang and Lili Wang and Chang Guo and Shiqi Liu and Yi Rong and Jiawen Tian and Chao Peng and Yuying Shao and Zhixiong Ma and Na Li and Jingliang Zhang and Zijun Peng and Xu Yan and Hangwei Fa and Xinyue Ma and Jie Dong and Jinping Ji and Chen Yang and Haocheng Chen and Jing Liang and Qi Sun and Yang Yang and Weining Ma and Zhuo Huang}, doi = {10.1002/advs.202416315}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e16315}, shortjournal = {Adv. Sci.}, title = {The DEC2-SCN2A axis is essential for the anticonvulsant effects of cannabidiol by modulating neuronal plasticity}, volume = {12}, year = {2025}, }
• (2025). Optogenetic-controlled iPSC-based vaccines for prophylactic and therapeutic tumor suppression in mice. ADVS, 12(36), e16115. (www)

  @article{ , abstract = {Induced pluripotent stem cells (iPSCs) share similar cellular features and various antigens profiles with cancer cells. Leveraging these characteristics, iPSCs hold great promise for developing wide-spectrum vaccines against cancers. In practice, iPSCs are typically combined with immune adjuvants to enhance antitumor immune responses; however, traditional adjuvants lack controllability and can induce systemic toxicity, which has limited their broad application. Here, a r ed/far-red light-controlled i PSC-based va ccine (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 is developed; RIVA preserves the intrinsic tumor antigens of iPSCs and enables optogenetic control of an immune adjuvant's (IFN-β) expression under red light illumination. Experiments in multiple mouse tumor models demonstrate that RIVA inhibits tumor growth and improves animal survival in prophylactic and therapeutic settings, including against pulmonary metastatic 4T1 breast cancer. RIVA efficiently stimulates dendritic cell maturation, eliciting innate immune activation effects through NK cells and elicit adaptive immune anti-tumor responses through CD4 + and CD8 + T cells. Moreover, RIVA protects animals against tumor re-challenge by inducing strong immunological memory, with minimal systemic toxicity. This study demonstrates RIVA as an effective optogenetic approach for developing safe multi-antigen vaccines for the prevention and treatment of cancer.}, archive = {J_ADVS}, author = {Longliang Qiao and Lingxue Niu and Zhihao Wang and Di Dai and Shasha Tang and Xiaoding Ma and Zhenqiang Deng and Guiling Yu and Yang Zhou and Tao Yan and Xingwan Liu and Deqiang Kong and Linfeng Hu and Xiang Li and Junwei Zhao and Fengfeng Cai and Meiyan Wang and Haifeng Ye}, doi = {10.1002/advs.202416115}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e16115}, shortjournal = {Adv. Sci.}, title = {Optogenetic-controlled iPSC-based vaccines for prophylactic and therapeutic tumor suppression in mice}, volume = {12}, year = {2025}, }
• (2025). POLE deficiency exacerbates diesel engine exhaust-induced genomic instability and malignant transformation of bronchial epithelial cells. ADVS, 12(36), e15943. (www)

  @article{ , abstract = {Diesel engine exhaust (DEE) is classified as a Group I carcinogen, yet direct experimental evidence that DEE induce carcinogenesis is lacking. Here, it is innovatively discovered that 120 µg mL −1 DEE exposure for 20 weeks, original bronchial epithelial cells exhibit abnormal morphology, form colonies in soft agar, and readily develop the lumps under the subcutaneous tissue of immunodeficient mice, which are pathologically confirmed as lung squamous cell carcinoma. Whole genome sequencing and RNA sequencing identify DEE-induced mutational signatures (DBS3, ID1/ID2), associated with polymerase epsilon (POLE) exonuclease domain mutations and mismatch repair (MMR) deficiency. Besides, 52 exonic mutations, 734 copy number variations (CNVs), and 2519 differentially expressed genes (DEGs) are discovered which are enriched in the suppressed DNA damage repair pathways and the activated lung cancer related signaling pathways including JAK-STAT, PI3K-Akt, MAPK in the DEE-induced malignant transformed cells. Further assays confirm DEE-induced malignant transformed cells harbor both POLE and MMR defects, leading to high mutation burden and genomic instability. Additionally, POLE deficiency exacerbates DEE-induced DNA damage and genomic instability, promoting the cell malignant transformation. This study highlights the importance of gene-environment interaction in carcinogenesis and emphasizes the critical role of POLE deficiency in DEE-induced malignant transformation of lung cells.}, archive = {J_ADVS}, author = {Pimei Zhang and Zhaoxu Wu and Qiang Ju and Nuo Xu and Xian Chen and Hongguang Chen and Shuaishuai Yang and Jing Ji and Yanjie Zhao}, doi = {10.1002/advs.202415943}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e15943}, shortjournal = {Adv. Sci.}, title = {POLE deficiency exacerbates diesel engine exhaust-induced genomic instability and malignant transformation of bronchial epithelial cells}, volume = {12}, year = {2025}, }
• (2025). WSGC@FA@PEG/PEI-SPIONs mitigate chemoresistance in gastric adenocarcinoma by modulating the notch signaling pathway and mitophagy. ADVS, 12(36), e15840. (www)

  @article{ , abstract = {This study investigates the molecular mechanisms by which superparamagnetic iron oxide nanoparticles (SPIONs) loaded with the WSGC peptide (WSGC@FA@PEG/PEI-SPIONs)—a 40-amino acid polypeptide derived from apoC-III—modulate chemotherapy resistance in gastric adenocarcinoma (GA). Emphasis is placed on their role in regulating mitophagy and mitochondrial homeostasis via the Notch signaling pathway. The physicochemical properties of WSGC@FA@PEG/PEI-SPIONs are thoroughly characterized, demonstrating favorable biocompatibility, stable size distribution, and efficient peptide loading. In vitro experiments show that these nanoparticles significantly inhibit GA cell proliferation, migration, and invasion by downregulating mitophagy-associated proteins (LC3, PINK1, and Parkin), primarily through modulation of the Notch pathway. In vivo studies, using a GA nude mouse model, confirm the therapeutic potential of WSGC@FA@PEG/PEI-SPIONs, revealing marked tumor growth inhibition and increased apoptotic activity. Collectively, the findings highlight the WSGC peptide as a promising therapeutic agent for overcoming chemotherapy resistance in GA by targeting the Notch signaling pathway and suppressing mitophagy, thereby presenting a novel strategy for polypeptide-based cancer therapy.}, archive = {J_ADVS}, author = {Dongjian Song and Qiuliang Liu and Zechen Yan and Qi Wang and Meng Su and Hui Zhang and Longyan Shi and Yingzhong Fan and Qian Zhang and Heying Yang and Da Zhang}, doi = {10.1002/advs.202415840}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e15840}, shortjournal = {Adv. Sci.}, title = {WSGC@FA@PEG/PEI-SPIONs mitigate chemoresistance in gastric adenocarcinoma by modulating the notch signaling pathway and mitophagy}, volume = {12}, year = {2025}, }
• (2025). Disruption of ARID1B recruitment to the nuclear pore complex as a new anticancer therapeutic strategy. ADVS, 12(36), e15585. (www)

  @article{ , abstract = {Triple-negative breast cancer (TNBC), a highly aggressive subtype, currently lacks potent targeted therapies. ARID1B, a key SWI/SNF chromatin remodeling complex subunit, is linked to high-grade malignancies and poor prognosis, making it a potential biomarker and therapeutic target. However, its function and regulation remain unclear. Here, it is found that uncontrolled accumulation of ARID1B and its dysregulated nuclear import promoted oncogenesis and drug resistance. ARID1B negatively regulates ARID1A, impairing SWI/SNF-mediated tumor suppression and enhancing tumor survival. Using protein complex purification and mass spectrometry, the KPNA2–KPNB1–RANBP2 protein cascade is identified as critical for facilitating ARID1B nuclear import. Replacing R1518, H1519, and D1522 residues on ARID1B with T1518, G1519, and G1522 attenuates the ARID1B–KPNA2/KPNB1 interaction, preventing recruitment of ARID1B to the nuclear pore complex (NPC). Pharmacologically inhibiting KPNB1 suppressed ARID1B translocation, limiting its nuclear levels. In TNBC mouse models, ARID1B knockout (KO) significantly reduces tumor growth and enhances PARP inhibitor efficacy. Collectively, these findings uncover an undocumented mechanism for ARID1B nuclear translocation and reveal that blockade of ARID1B nuclear translocation can be a new therapeutic strategy for TNBC.}, archive = {J_ADVS}, author = {Olena Odnokoz and Anupam Banerjee and Xin Cui and Lidan Zeng and Amad Uddin and Christopher Li and Yueming Zhu and Mengyuan Zhang and Xiaodong Lu and Nagendra S. Yarla and Lu Wang and Jindan Yu and Jonathan C. Zhao and Ivet Bahar and Yong Wan}, doi = {10.1002/advs.202415585}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e15585}, shortjournal = {Adv. Sci.}, title = {Disruption of ARID1B recruitment to the nuclear pore complex as a new anticancer therapeutic strategy}, volume = {12}, year = {2025}, }
• (2025). Correction to [Synthetic biomimetic liposomes harness efferocytosis machinery for highly efficient macrophages-targeted drug delivery to alleviate inflammation]. ADVS, 12(36), e15155. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202515155}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e15155}, shortjournal = {Adv. Sci.}, title = {Correction to [Synthetic biomimetic liposomes harness efferocytosis machinery for highly efficient macrophages-targeted drug delivery to alleviate inflammation]}, volume = {12}, year = {2025}, }
• (2025). Chronic psychological stress induces cardiomyocyte hypertrophy through corticosterone-glucocorticoid receptor-LAMA5 axis. ADVS, 12(36), e14659. (www)

  @article{ , abstract = {Chronic psychological stress is closely related to myocardial diseases, but the pathological processes and related mechanisms are not yet clear. In this study, 5 batches of animal experiments are conducted to reveal the pathological process of chronic psychological stress on the heart, and found that cardiomyocyte hypertrophy is an early manifestation of cardiac damage. Furthermore, it is discovered that corticosterone and glucocorticoid receptor (GR) play an important role in mediating this phenomenon. Additionally, a new direct target gene of GR, Lama5 , is identified and confirmed in vivo and in vitro that the corticosterone-GR-LAMA5 axis is a significant pathway mediating chronic psychological stress-induced cardiomyocyte hypertrophy. Moreover, the potential of LAMA5 is validated as a biomarker for myocardial hypertrophy and impaired cardiac function in patients with depression. In summary, a novel hypertrophy-related gene, Lama5 has been identified, that may play an important role in chronic psychological stress-induced cardiomyocyte hypertrophy.}, archive = {J_ADVS}, author = {Chuanjing Zhang and Yongfei Song and Xiaojun Jin and Qingbo Xu and Honghua Ye and Zhuonan Wu and Hui Lin and Jiale Hu and Chen Huang and Jianqing Zhou and Jiangfang Lian}, doi = {10.1002/advs.202414659}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e14659}, shortjournal = {Adv. Sci.}, title = {Chronic psychological stress induces cardiomyocyte hypertrophy through corticosterone-glucocorticoid receptor-LAMA5 axis}, volume = {12}, year = {2025}, }
• (2025). RIG-I-inducing small molecules potently inhibit HMA-resistant AML through igniting the overloaded dsRNA arsenal. ADVS, 12(36), e14477. (www)

  @article{ , abstract = {DNA hypomethylating agents (HMAs) are widely used to treat acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS), but most treated patients relapse and lack standard treatment options. Using high-throughput screening, the approved all-trans retinoic acid (ATRA) is identified that exhibit high selectivity in killing HMA-resistant AML cells compared to parental cells. Mechanistically, HMA-resistant cells are overloaded with DNA hypomethylation-associated endogenous viral double-stranded RNA (dsRNA) which, however, fails to trigger an anticancer interferon (IFN) immune response due to downregulation of dsRNA sensor retinoic acid-inducible gene I (RIG-I). ATRA compensates for RIG-I expression, thereby re-triggering IFN response and potently inhibiting HMA-resistant AML cell lines, xenograft mice, and patient-derived primary cells. A library of potential RIG-I-inducing compounds is rationally constructed and screened, in which the approved M3 AML treatment drug tamibarotene (TAM) exhibits strikingly 28036-fold selectivity and 779 p m IC 50 in killing HMA-resistant AML cells. ATRA and TAM do not selectively inhibit p53-mutant cancer cells. Together, this study uncovers a common resistance mechanism in HMA-treated AML patients and, in addition, provides highly potent and selective agents that can overcome resistance through re-triggering IFN anticancer immune response.}, archive = {J_ADVS}, author = {Xueqin Chen and Jiaqi Wu and Yuntong Li and Jiayu Huang and Xiangqin Weng and Jiale Wu and Shujun Xiao and Huaxin Song and Zhengyuan Wang and Ni Yan and Fangfang Shi and Derun Zheng and Kai Tan and Hesong Zhang and Jingyi Cui and Wen Wu and Wei Wu and Sujiang Zhang and Min Lu}, doi = {10.1002/advs.202414477}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e14477}, shortjournal = {Adv. Sci.}, title = {RIG-I-inducing small molecules potently inhibit HMA-resistant AML through igniting the overloaded dsRNA arsenal}, volume = {12}, year = {2025}, }
• (2025). Correction to “[Cocktail cell-reprogrammed hydrogel microspheres achieving scarless hair follicle regeneration]”. ADVS, 12(36), e14108. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202514108}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e14108}, shortjournal = {Adv. Sci.}, title = {Correction to “[Cocktail cell-reprogrammed hydrogel microspheres achieving scarless hair follicle regeneration]”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Plasma-activated hydrogels for microbial disinfection”. ADVS, 12(36), e13989. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202513989}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e13989}, shortjournal = {Adv. Sci.}, title = {Correction to “Plasma-activated hydrogels for microbial disinfection”}, volume = {12}, year = {2025}, }
• (2025). Dual-crosslinked betaine-based amphiphilic hydrogel as a promising vitreous substitute: Anti-adhesion, anti-fouling, and anti-cell proliferation. ADVS, 12(36), e13455. (www)

  @article{ , abstract = {Developing an ideal vitreous substitute remains a significant challenge in ophthalmic surgery. This study introduces a novel dual-crosslinked betaine-based amphiphilic polymer hydrogel (BAPHs) synthesized via in situ free radical copolymerization. The resulting BAPHs exhibit tunable viscoelasticity, intrinsic self-healing property, injectability, stable micromorphology, and optical transparency, all modifiable by adjusting the chemical cross-linker content. When tested in a vitrectomized rabbit model, the BAPHs demonstrated optimal optical properties, mechanical stability, and promising biocompatibility. These results suggest that the BAPHs offer a transformative approach to vitreous substitution, with the potential to overcome the limitations of current clinical materials, offering both structural and functional benefits.}, archive = {J_ADVS}, author = {Yuting Cai and Yun Tan and Jian Cao and Xiaoyuan Zhou and Xingyuan Li and Jianghua Li and Chuntai Liu and Yi Zhang and Yun Li}, doi = {10.1002/advs.202413455}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e13455}, shortjournal = {Adv. Sci.}, title = {Dual-crosslinked betaine-based amphiphilic hydrogel as a promising vitreous substitute: Anti-adhesion, anti-fouling, and anti-cell proliferation}, volume = {12}, year = {2025}, }
• (2025). USP10 inhibits ferroptosis via deubiquinating POLR2A in head and neck squamous cell carcinoma. ADVS, 12(36), e12271. (www)

  @article{ , abstract = {Ferroptosis has become a new way to induce cell death in cancer therapy. Deubiquitinating enzymes (DUBs) contribute to cancer ferroptosis, but underlying mechanisms are not completely understood. Here, it is discovered that USP10 as a member of DUBs, is tightly associated with a poor prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Functionally, USP10 inhibits ferroptosis via transcriptionally upregulating the expression of SLC7A11 in HNSCC. Targeting USP10 via gene depletion and antagonist sensitizes HNSCC cells to ferroptosis inducers both in vitro and in vivo. Mechanistically, USP10 directly interacts with the largest RNA Polymerase II Subunit A (POLR2A), removes the K48- and K63-linked ubiquitin chains of POLR2A through its deubiquitinase activity and prevents ubiquitin-mediated degradation. Then, POLR2A transcriptionally activates SLC7A11 , eventually leading to the suppression of ferroptosis. Overall, the study indicates that a novel USP10-POLR2A-SLC7A11 axis regulates ferroptosis, positioning USP10 as a potential therapeutic target in patients with HNSCC.}, archive = {J_ADVS}, author = {Diekuo Zhang and Xueying Wang and Shanhong Lu and Yan Gao and Gangcai Zhu and Guo Li and Zongnan Yu and Junwei Hou and Helei Yan and Wenhui Yuan and Xin Zhang and Mien-Chie Hung and Zhifeng Liu and Yong Liu}, doi = {10.1002/advs.202412271}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e12271}, shortjournal = {Adv. Sci.}, title = {USP10 inhibits ferroptosis via deubiquinating POLR2A in head and neck squamous cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Cryptic splicing of GAP43 mRNA is a novel hallmark of TDP-43-associated ALS and AD. ADVS, 12(36), e12054. (www)

  @article{ , abstract = {Cytoplasmic aggregation of transactive response DNA-binding protein 43 (TDP-43) is a hallmark of amyotrophic lateral sclerosis (ALS) and occurs in 57% of Alzheimer's disease (AD) cases. TDP-43 regulates RNA processing, including cryptic exon splicing. Here, we demonstrate that TDP-43 directly controls growth-associated protein (GAP43) expression by binding to its pre-mRNA. Loss or hyperphosphorylation of TDP-43 disrupts this binding, leading to the inclusion of cryptic exon 4a1 , which introduces premature stop codons and reduces GAP43 protein levels. RNA sequencing analysis of ALS and AD brains revealed GAP43 downregulation, while 4a1 is upregulated in AD cases with phosphorylated TDP-43. TDP-43 knockdown impaired axonal regeneration in induced pluripotent stem cell (iPSC)-derived motor neurons, whereas GAP43 restoration rescued this defect. These findings suggest that the loss of GAP43 contributes to neurodegeneration in ALS and AD. The inclusion of GAP43 cryptic exon 4a1 may serve as a hallmark of TDP-43 proteinopathies, highlighting a mechanistic link between TDP-43 dysfunction and neuronal vulnerability.}, archive = {J_ADVS}, author = {Mingming Yang and Qi Wang and Dongkun Kang and Shijia Wang and Yanli Jiang and Jian-Zhi Wang and Chen Ming and Rong Liu and Jianlan Gu and Xiaochuan Wang}, doi = {10.1002/advs.202412054}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e12054}, shortjournal = {Adv. Sci.}, title = {Cryptic splicing of GAP43 mRNA is a novel hallmark of TDP-43-associated ALS and AD}, volume = {12}, year = {2025}, }
• (2025). Acod1 promotes PAD4 ubiquitination via UBR5 alkylation to modulate NETosis and exert protective effects in sepsis. ADVS, 12(36), e11652. (www)

  @article{ , abstract = {Neutrophil extracellular traps (NETs) are reticular structures released by neutrophils, and the process of their formation is called NETosis. NETs play a key role in the pathological process of sepsis. However, the specific regulatory mechanism has not been fully clarified. This study finds that the levels of NETs in peripheral blood are significantly elevated in clinical sepsis patients and cecal ligation and puncture (CLP) mouse models, and the expression of Acod1 is closely related to the generation of NETs. Acod1 knockout led to a further increase in NETs levels in CLP mice, aggravated the inflammatory response, worsened organ damage, and reduced the survival rate. Further studies indicate that E3 ubiquitin ligase UBR5 interacts with PAD4 (one of the core proteins for NETs generation). Acod1/itaconate (ITA) enhanced the enzymatic activity of UBR5 through alkylation modification, promoting the K48-linked polyubiquitination and degradation of PAD4, thereby inhibiting NETosis. In conclusion, this study combines transcriptomics, metabolomics, genetic engineering, and co-immunoprecipitation techniques to reveal the molecular mechanism of Acod1/ITA in regulating NETs, providing new potential targets and theoretical basis for the treatment of sepsis.}, archive = {J_ADVS}, author = {Huifan Liu and Guoqing Jing and Shujuan Wu and Min Yuan and Yingyue Dong and Xue Chen and Huimin Zhou and Hailong Gong and Jing Zuo and Xiaojing Wu and Xuemin Song}, doi = {10.1002/advs.202411652}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e11652}, shortjournal = {Adv. Sci.}, title = {Acod1 promotes PAD4 ubiquitination via UBR5 alkylation to modulate NETosis and exert protective effects in sepsis}, volume = {12}, year = {2025}, }
• (2025). Post-treatment strategies toward high-quality Sb2Se3 thin films in photovoltaic applications. ADVS, 12(36), e11387. (www)

  @article{ , abstract = {Antimony selenide (Sb 2 Se 3 ) has attracted increasing attention as a promising photovoltaic absorber due to its superior optoelectronic properties and ample application potential in thin-film solar cells. High-performance Sb 2 Se 3 solar cell is closely tied to the quality of Sb 2 Se 3 active layer, which requires careful design of the interfacial and bulk defects, as well as crystallinity of the thin films. Postprocessing procedures show great potential to address defect issues and improve the conductivity of solar cells. Therefore, developing efficient and reliable post-treatment techniques is crucial for advancing Sb 2 Se 3 solar cell technology. In this review, recent post-treatment methodologies are summarized toward high-quality Sb 2 Se 3 thin films, categorizing the strategies into two main types: thermal annealing (TA)-related techniques and TA-free techniques. Furthermore, the effects of these strategies are discussed on Sb 2 Se 3 crystal characteristics, including defects, optoelectronic properties, and film morphology, all of which are closely related to device performance. Finally, the critical challenges and perspectives are proposed regarding this new solar cell materials, practical guidelines are also provided for fabricating high-quality Sb 2 Se 3 layers for highly efficient Sb 2 Se 3 solar cells.}, archive = {J_ADVS}, author = {Qi Zhao and Rongfeng Tang and Shangfeng Yang and Tao Chen}, doi = {10.1002/advs.202511387}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e11387}, shortjournal = {Adv. Sci.}, title = {Post-treatment strategies toward high-quality Sb2Se3 thin films in photovoltaic applications}, volume = {12}, year = {2025}, }
• (2025). Advances in high-entropy catalysts for Lithium–Sulfur batteries: Design principles, recent progress, and prospects. ADVS, 12(36), e11072. (www)

  @article{ , abstract = {Lithium–sulfur (Li–S) batteries are regarded as one of the most promising next-generation energy storage technologies due to their exceptionally high theoretical energy density, cost-effectiveness, and environmental sustainability. Nevertheless, their practical deployment is significantly constrained by several challenges, including the intrinsic low conductivity of sulfur, the shuttle effect of lithium polysulfides (LiPS), sluggish redox kinetics, and instability of the Li anode. To overcome these limitations, the integration of catalytic materials has emerged as an effective strategy to accelerate sulfur redox reactions, promote LiPS conversion, and enhance cycling stability. Recently, high-entropy catalysts (HEC), comprising five or more metallic elements in near-equimolar ratios, have garnered increasing attention owing to their entropy-stabilized structures, abundant active sites, and tunable electronic properties. This review presents a comprehensive overview of the design principles, synthesis methods, and electrochemical applications of various HEC families, including high-entropy alloys, oxides, sulfides, nitrides, phosphides, MXenes, and Prussian blue analogues, in Li–S battery systems. The synergistic effects arising from multicomponent interactions, structural advantages, and underlying catalytic mechanisms are systematically discussed. Finally, key challenges such as scalable synthesis, in-depth mechanistic elucidation, and rational compositional design are addressed, along with future directions aimed at advancing high-performance HEC-based Li–S battery systems.}, archive = {J_ADVS}, author = {Ruohan Hou and Yixin Wei and Jiaxiang Zhang and Jiaying Chen and Shaojie Chen and Shuaiting Sun and Guosheng Shao and Peng Zhang}, doi = {10.1002/advs.202511072}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e11072}, shortjournal = {Adv. Sci.}, title = {Advances in high-entropy catalysts for Lithium–Sulfur batteries: Design principles, recent progress, and prospects}, volume = {12}, year = {2025}, }
• (2025). A review of designing hierarchical structure within membrane electrode assembly for water electrolyzer. ADVS, 12(36), e10546. (www)

  @article{ , abstract = {Green hydrogen produced from water electrolyzers demonstrates higher efficiency and sustainability than industrial alkaline water electrolysis due to the membrane electrode assembly (MEA) design. However, random structure designs in current MEAs significantly increase the charge and mass transport resistance, leading to a decrease in energy efficiency. In contrast, the ordered structure design in MEA provides well-defined arrangements of pores, channels, or pathways within catalysts, catalyst layers, porous transport layers, and ion exchange membranes (IEMs). These ordered configurations facilitate efficient pathways for charge and mass transport. Particularly, in comparison with first-order structure, hierarchical structure designs exhibit more obvious advantages in reaction interface, charge, and mass transport. Recently, the diverse hierarchical structure in the MEA designs has demonstrated significant improvements in overall electrolysis efficiency in both proton exchange membrane (PEM) and anion exchange membrane (AEM) water electrolyzers. This review will examine recent advancements in hierarchical structure designs in the MEAs for water electrolyzers, focusing on innovations in fabrication methods and enhancement mechanisms, as well as their electrolysis performance. This review will provide comprehensive guidelines for designing highly efficient MEAs for both PEM and AEM electrolyzers.}, archive = {J_ADVS}, author = {Saifei Pan and Yongqi Ye and Chuyu Zhang and Xin Chen and Xuetao Wang and Chunmei Liu and Haojie Li and Bin Tian and Fang Wang and Zongkui Kou}, doi = {10.1002/advs.202510546}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e10546}, shortjournal = {Adv. Sci.}, title = {A review of designing hierarchical structure within membrane electrode assembly for water electrolyzer}, volume = {12}, year = {2025}, }
• (2025). Why will polymers win the race for solid-state batteries?. ADVS, 12(36), e10481. (www)

  @article{ , abstract = {Solid-state batteries (SSBs) promise to revolutionize energy storage by offering enhanced safety, higher energy density, and improved cycle lifespan over conventional lithium-ion batteries. Among the various solid electrolytes, polymers stand out for their unique combination of processability, mechanical compliance, and chemical versatility. This review explores why polymers are poised to lead the race toward commercial SSBs. Their intrinsic advantages—such as superior interfacial contact with electrodes, tunable ionic conductivity, and compatibility with scalable manufacturing methods—as well as the key technical challenges they face, including limited thermal stability, narrow electrochemical windows, and interfacial degradation, are examined. This study highlights emerging solutions from recent research, including polymer molecular design, polymer–ceramic composites, and in situ polymerization strategies. In contrast to oxide and sulfide systems, which face significant barriers in cost, manufacturability, and integration, polymer-based electrolytes offer a realistic and economically viable path to large-scale deployment. With continuing advances in materials design and industrial processing, polymers are not only competitive—they are leading the transition to next-generation solid-state batteries.}, archive = {J_ADVS}, author = {Zhiyong Li and Sisi Peng and Lu Wei and Xin Guo}, doi = {10.1002/advs.202510481}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e10481}, shortjournal = {Adv. Sci.}, title = {Why will polymers win the race for solid-state batteries?}, volume = {12}, year = {2025}, }
• (2025). Electrochemistry as a tool for redox-based bio-information processing. ADVS, 12(36), e10184. (www)

  @article{ , abstract = {Redox, a native modality in biology involving the flow of electrons, energy, and information, is used for energy-harvesting, biosynthesis, immune-defense, and signaling. Because electrons (in contrast to protons) are not soluble in the medium, electron-flow through the redox modality occurs through redox reactions that are sometimes organized into pathways and networks (e.g., redox interactomes). Redox is also accessible to electrochemistry, which enables electrodes to receive and transmit electrons to exchange energy and information with biology. In this Perspective, efforts to develop electrochemistry as a tool for redox-based bio-information processing: to interconvert redox-based molecular attributes into interpretable electronic signals, are described. Using a series of Case Studies, how the information-content of the measurements can be enriched using: diffusible mediators; tuned electrical input sequences; and cross-modal measurements (e.g., electrical plus spectral), is shown. Also, theory-guided feature engineering approaches to compress the information in the electronic signals into quantitative metrics (i.e., features) that can serve as correlating variables for pattern recognition by data-driven analysis are described. Finally, how redox provides a modality for electrogenetic actuation is illustrated. It is suggested that electrochemistry's capabilities to provide real-time, low-cost, and high-content data in an electronic format allow the feedback-control needed for autonomous learning and deployable sensing/actuation.}, archive = {J_ADVS}, author = {Eunkyoung Kim and Chen-yu Chen and Fauziah Rahma Zakaria and Dana Motabar and Mijeong Kang and Deanna L. Kelly and Alessandra Napolitano and William E. Bentley and Gregory F. Payne}, doi = {10.1002/advs.202510184}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e10184}, shortjournal = {Adv. Sci.}, title = {Electrochemistry as a tool for redox-based bio-information processing}, volume = {12}, year = {2025}, }
• (2025). Correction to “[Berberine is a novel mitochondrial calcium uniporter inhibitor that disrupts MCU-EMRE assembly]”. ADVS, 12(36), e10152. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202510152}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e10152}, shortjournal = {Adv. Sci.}, title = {Correction to “[Berberine is a novel mitochondrial calcium uniporter inhibitor that disrupts MCU-EMRE assembly]”}, volume = {12}, year = {2025}, }
• (2025). Synthesis of diaryl- and dialkynylphosphinates from ubiquitous PV sources via a redox-neutral approach. ADVS, 12(36), e09922. (www)

  @article{ , abstract = {Organophosphinic acids, R 2 P(O)(OH), and their derivatives are versatile compounds with applications in catalysis, material chemistry, biomolecular bridging, metal extraction, and flame retardancy. Current synthetic methods primarily rely on white phosphorus (P 4 ) as a precursor, which is converted into nucleophilic or electrophilic P-synthons through acid-/base-induced disproportionation (e.g., PH 3 , [H 2 PO 2 ] – ) or chlorination (PCl 3 ). However, P 4 poses significant drawbacks due to its highly pyrophoric nature, environmental hazards, and the energy-intensive production process from phosphate ores. Previously, we introduced a method to bypass P 4 in the synthesis of P V compounds through the redox-neutral activation of phosphates using trifluoromethanesulfonic anhydride (Tf 2 O) and pyridine, yielding the electrophilic PO 2 + phosphorylation reagent [(pyridine) 2 PO 2 ][OTf] ( 1a [OTf]). While this reagent exhibits high selectivity for alcohols, amides, and (pseudo)halides, it failed to react efficiently with organometallic compounds to form organophosphinates. Here, we present mechanistic studies that rationalize this limitation and report an optimized strategy, which successfully facilitates reactions with Grignard reagents. By replacing the pyridine leaving group in 1a [OTf] with 4-dimethylaminopyridine (DMAP), the reagent [(DMAP) 2 PO 2 ][OTf] ( 1b [OTf]) is obtained, which enables the selective synthesis of a broad range of diaryl- and dialkynylphosphinates, thereby expanding the scope of redox-neutral phosphate activation.}, archive = {J_ADVS}, author = {Tobias Schneider and Kai Schwedtmann and Jannis Fidelius and Rosa M. Gomila and Antonio Frontera and Jan J. Weigand}, doi = {10.1002/advs.202509922}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e09922}, shortjournal = {Adv. Sci.}, title = {Synthesis of diaryl- and dialkynylphosphinates from ubiquitous PV sources via a redox-neutral approach}, volume = {12}, year = {2025}, }
• (2025). Emerging cGAS-STING agonist-based nanotherapeutics: Mechanistic insights and applications in cancer combination therapy. ADVS, 12(36), e09890. (www)

  @article{ , abstract = {The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a promising target for cancer immunotherapy. Activation of the cGAS-STING pathway holds significant potential to enhance antitumor immunity. However, their efficacy remains constrained by various drug delivery and pharmacological obstacles, including poor stability, limited cellular uptake, inefficient intracellular delivery, suboptimal tumor targeting, and immunotoxicity. There is a growing focus on the design and application of nanoparticulate drug delivery systems (nano-DDSs) to improve the delivery of cGAS-STING agonists for safe, effective, and specific targeting. This review outlines the latest advancements in cGAS-STING agonist-based nanotherapeutics. First, the research background of the cGAS-STING pathway and nanotechnology is briefly outlined to emphasize the promise of STING agonist-based nanotherapeutics in cancer immunotherapy. Second, the progress in the development of cGAS-STING agonists and recent advancements in cGAS-STING agonist-based nanotherapeutics are overviewed. Moreover, the molecular mechanisms and applications of STING agonist-based combination therapies are discussed, including synergistic strategies with chemotherapy, radiotherapy, immunotherapy (e.g., immune checkpoint blockade (ICB), indoleamine 2,3-dioxygenase (IDO) inhibitor, cancer vaccine, adoptive cell therapy (ACT)), phototherapy, sonodynamic therapy (SDT), and targeted therapy. Finally, the challenges and future perspectives of STING agonist-based nanotherapeutics in clinical cancer therapy are proposed.}, archive = {J_ADVS}, author = {Zhaomeng Wang and Yongjun Wang and Zhonggui He and Caigang Liu}, doi = {10.1002/advs.202509890}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e09890}, shortjournal = {Adv. Sci.}, title = {Emerging cGAS-STING agonist-based nanotherapeutics: Mechanistic insights and applications in cancer combination therapy}, volume = {12}, year = {2025}, }
• (2025). Tryptophan metabolite indole-3-aldehyde induces AhR and c-MYC degradation to promote tumor immunogenicity. ADVS, 12(36), e09533. (www)

  @article{ , abstract = {The role of tryptophan (Trp) and its metabolites in immune regulation is well-established, however, whether and how they regulate immunogenicity of tumor cells is not completely understood. In this study, a range of Trp metabolites are evaluated for their potential to modulate tumor immunogenicity using a co-culture assay with tumor cells and T cells. Indole-3-aldehyde (I3A) is identified as an indole derivative that significantly enhances tumor immunogenicity both in vitro and in vivo. This enhancement is attributed to the upregulation of antigen presentation and immunogenic molecules on tumor cells by I3A, thereby promoting their immunogenicity. Mechanistically, I3A induces the activation and degradation of Aryl hydrocarbon receptor (AhR), leading to increased expression of MHC-I molecules on tumor cell surfaces. Meantime, I3A induces rapid degradation of c-MYC in tumor cells and further enhances T cell activation. In mouse melanoma and lymphoma models, I3A demonstrates immune-dependent antitumor effects and enhances the efficacy of adoptive OT-I T cell therapy. Moreover, overexpression of the Trp metabolic enzyme interleukin-4-induced gene-1 (IL4I1) in tumor cells increases the intracellular level of I3A and enhances tumor immunogenicity. In summary, I3A is identified as a tumor immunogenicity inducer, which holds the potential to enhance antitumor immunotherapy efficacy.}, archive = {J_ADVS}, author = {Lei Cui and Zining Wang and Zixuan Guo and Hongxia Zhang and Yongxiang Liu and Huanling Zhang and Huan Jin and Feifei Xu and Xiaojuan Wang and Chunyuan Xie and Hui Guo and Tiantian Wang and Yanxun Lin and Qi Zhao and Penghui Zhou and Jing Tan and Jin-Xin Bei and Peng Huang and Jinyun Liu and Xiaojun Xia}, doi = {10.1002/advs.202409533}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e09533}, shortjournal = {Adv. Sci.}, title = {Tryptophan metabolite indole-3-aldehyde induces AhR and c-MYC degradation to promote tumor immunogenicity}, volume = {12}, year = {2025}, }
• (2025). Interfacial stress regulates plasticity and drug resistance at the breast cancer-host interface. ADVS, 12(36), e09361. (www)

  @article{ , abstract = {The confinement of breast cancer cells at the interface of the mammary gland lumen and its surrounding extracellular matrix is thought to be a key physical driver of cellular plasticity. The relationship between confinement-induced solid stress and drug resistance is not well understood due to a scarcity of models that faithfully isolate the contribution of confinement on cancer cell behavior. Herein, drop-on-demand printing is used to uniquely replicate the spatial compartmentalization of the native cancer-host interface: MCF-7 breast cancer cells are dispensed within bioinert cup-shaped alginate-based hydrogels in high-throughput to yield “confined” spheroids. Hydrogel confinement affects the emergence of CD44+-CD133+ cells at the spheroid interface that drives a two-fold increase in doxorubicin/tamoxifen resistance compared to control “unconfined” spheroids. Whilst the peripheral drug-resistant phenotype is observed clinically, the model is unique in facilitating the emergence of this population in an in vitro setting. Pharmacological modulation of mechanotransduction proteins (YAP, myosin), abrogated the emergence of this peripheral phenotype, implicating mechanotransduction pathways as an effective way to target solid stress-induced drug resistance. Together, this supports an “interfacial stress—stemness—drug resistance” relationship that sheds new light on the existing paradigm of spatial emergence of drug resistance in breast cancer.}, archive = {J_ADVS}, author = {Bram G. Soliman and Peilin Tian and Jiuyu Cui and Kristopher A. Kilian and J. Justin Gooding}, doi = {10.1002/advs.202509361}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e09361}, shortjournal = {Adv. Sci.}, title = {Interfacial stress regulates plasticity and drug resistance at the breast cancer-host interface}, volume = {12}, year = {2025}, }
• (2025). Graphene-inspired mono-elemental 2D materials: Synthesis, properties, and potential applications of xenes. ADVS, 12(36), e09262. (www)

  @article{ , abstract = {Xenes, a class of mono-elemental two-dimensional (2D) materials, have emerged as promising candidate materials for next-generation electronic and energy devices due to their unique structural and electronic properties. This review first systematically categorizes the eighteen experimentally realized Xenes into Group III–VI and other group categories, summarizing their synthesis routes, ranging from top-down exfoliation to bottom-up methods. Based on density functional theory (DFT), this paper focuses on theoretical predictions of stable phases and substrate interactions, which guide experimental preparation. Second, functional applications of Xenes in electronics, optoelectronics, catalysis, energy storage, and biomedicine are also reviewed. The impact of atomic configurations on synthesis difficulty, environmental stability, and scalability across different element groups is also discussed. Finally, emerging strategies such as encapsulation, heterostructure design, and machine learning-guided growth are evaluated to overcome inherent limitations. This paper provides a comprehensive overview of synthesis principles, structure-property relationships, and stabilization strategies, offering insights into future scalable and robust Xene development directions.}, archive = {J_ADVS}, author = {Yufan Yang and Yuqin Xiao and Qingxin Zhang and Yuxin Yan and Tao Wu and Cheng Heng Pang}, doi = {10.1002/advs.202509262}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e09262}, shortjournal = {Adv. Sci.}, title = {Graphene-inspired mono-elemental 2D materials: Synthesis, properties, and potential applications of xenes}, volume = {12}, year = {2025}, }
• (2025). Insights into the mechanisms of immune-checkpoint inhibitors gained from spatiotemporal dynamics of the tumor microenvironment. ADVS, 12(36), e08692. (www)

  @article{ , abstract = {Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has revolutionized cancer treatment, yet durable responses are achieved in only a subset of patients. The tumor microenvironment (TME) plays a key role in cancer progression and immune modulation, critically influencing the efficacy of ICIs. Recent advances in single-cell technologies have enabled high-resolution profiling of the TME, particularly tumor-infiltrating immune cells, across diverse cancer types. However, our understanding of how immune cells shape ICI responses and how they are dynamically altered during treatment remains incomplete. In this review, we summarize recent progress in characterizing TME features associated with ICI responsiveness, highlighting key immune cell subsets involved in ICI therapy and emphasizing their phenotypic plasticity and functional adaptability following ICIs. Additionally, we outline the spatial architecture of the TME in terms of its effects on immune cell behavior and interactions, and discuss the critical role of stromal components and the microbiota in modulating the immune landscape and influencing ICI responsiveness. By integrating these insights, we aim to deepen our understanding of the cellular and molecular mechanisms underlying ICI responses, elucidate determinants of therapeutic sensitivity and resistance, and inform the development of more effective immunotherapeutic strategies.}, archive = {J_ADVS}, author = {Yuanyuan Zhang and Zhihua Liu}, doi = {10.1002/advs.202508692}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08692}, shortjournal = {Adv. Sci.}, title = {Insights into the mechanisms of immune-checkpoint inhibitors gained from spatiotemporal dynamics of the tumor microenvironment}, volume = {12}, year = {2025}, }
• (2025). Direct visualization of surface structure and charge states of ceria-supported gold catalysts under redox conditions. ADVS, 12(36), e08554. (www)

  @article{ , abstract = {Observing the surface structure and charge dynamics of catalysts during catalytic reactions is crucial for elucidating reaction mechanisms. However, nanoscale characterization of the catalyst structure and charge states in the presence of reactive gases presents experimental challenges. Here, the structures and charge states of a gold nanoparticle (NP) are directly visualized on ceria during redox cycles using electron holography, a method related to transmission electron microscopy. The introduction of oxidizing O 2 gas to the microscope led to structural changes on the NP surface and decrease the intrinsic negative charge of the NP. Conversely, under reducing H 2 gas, the surface structure and charge state of the NP remained almost unchanged compared to those in vacuum. Systematic analysis revealed that the injection and removal of O 2 gas caused reversible changes in the charge state of the NP within the range of a few electrons. The effect of O 2 gas on charging of the NP is confirmed by first-principles calculations. These findings demonstrate the potential of electron holography in gas environments for advancing the understanding the reaction mechanisms on heterogeneous catalysts.}, archive = {J_ADVS}, author = {Ryotaro Aso and Takehiro Tamaoka and Hideto Yoshida and Hajime Hojo and Hiroki Sano and Yoshihiro Midoh and Hisahiro Einaga and Toshiaki Tanigaki and Yasukazu Murakami}, doi = {10.1002/advs.202508554}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08554}, shortjournal = {Adv. Sci.}, title = {Direct visualization of surface structure and charge states of ceria-supported gold catalysts under redox conditions}, volume = {12}, year = {2025}, }
• (2025). Engineering separated dual o2 reduction cores into one polymer framework for boosting hydrogen peroxide production. ADVS, 12(36), e08553. (www)

  @article{ , abstract = {Photocatalytic hydrogen peroxide (H 2 O 2 ) production through the oxygen reduction reaction (ORR) pathway has emerged as a promising sustainable alternative. However, a significant challenge in this field lies in the development of highly efficient photocatalysts capable of achieving high-concentration H 2 O 2 production. Here the rational design of two O 2 reduction cores into one polymer framework is showcased for synergistically facilitating H 2 O 2 production via the “self-marketing & cooperation” strategy. Photoactive units of pyrrolo[3,2- b ] pyrrole and porphyrin are successfully settled in covalent organic polymers (COPs) through polycyclizations of the relevant aldehydes, anilines, and butane-2,3-dione. Two orderly separated active sites not only involve each of them in the oxygen reduction reaction but also mutually promote the production of H 2 O 2 , which is demonstrated by electron spin resonance experiments, in situ diffuse reflectance infrared Fourier transform spectroscopy, and a series of control experiments. Remarkably, PP-COP- 4 delivers an outstanding H 2 O 2 concentration of 16.2 m M in a continuous-flow system, demonstrating its strong potential for scalable, solar-driven production of commercial-grade H 2 O 2 .}, archive = {J_ADVS}, author = {Mengmeng Fu and Jialun He and Yingguo Li and Jiacheng Liu and Chensheng Wang and Jiayi Lu and Chaoyang Ma and Danfeng Jiang and Xiao Chen and Chao Yu}, doi = {10.1002/advs.202508553}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08553}, shortjournal = {Adv. Sci.}, title = {Engineering separated dual o2 reduction cores into one polymer framework for boosting hydrogen peroxide production}, volume = {12}, year = {2025}, }
• (2025). Bioinspired prolactin pulse release from responsive microneedles for inhibiting fatty liver formation. ADVS, 12(36), e08364. (www)

  @article{ , abstract = {Hormonal mechanisms of fatty liver formation require in-depth exploration, and corresponding therapeutic strategies are urgently needed. Here, through serological testing of mice with fatty liver, it is found that the rhythms of prolactin secretion are disturbed and that the circulating prolactin level is reduced. Based on these findings, prolactin's biological effects on fatty liver are investigated, and biomimetic photothermal-responsive core–shell microneedles with periodically prolactin releasing are proposed to inhibit lipid accumulation in liver. The microneedles are comprised of poly(lactic- co -glycolic acid) shells and prolactin-loaded cores of photothermal black phosphorus, phase-change gelatin, and carrageenan. Under periodically stimulation of near infrared (NIR), the prolactin in the microneedles can be released in a rhythmic manner for inhibiting the lipid accumulation in liver cells. Based on these features, it is demonstrated in mice with fatty liver that the bioinspired-responsive microneedles can facilitate prolactin mitigating hepatic steatosis through its interaction with the hepatic prolactin receptor (PRLR) and by modulating the expression of fatty acid translocase (FAT/CD36). Thus, these photothermal-responsive core–shell microneedles with prolactin pulse release hold significant promise for the treatment of fatty liver disease.}, archive = {J_ADVS}, author = {Hongli Yin and Wenjuan Tang and Danqing Huang and JingJing Gan and Pengzi Zhang and Yuanjin Zhao and Yan Bi}, doi = {10.1002/advs.202508364}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08364}, shortjournal = {Adv. Sci.}, title = {Bioinspired prolactin pulse release from responsive microneedles for inhibiting fatty liver formation}, volume = {12}, year = {2025}, }
• (2025). Nanoporous capillary gripper for ultragentle micro-object manipulation. ADVS, 12(36), e08338. (www)

  @article{ , abstract = {Surfaces become “sticky” at the micro/nano length scale as the gravitational force is no longer effective. Ultragentle, high-contrast switching of interfacial adhesion is the key to reliable small-scale object manipulation. Here, a novel approach is presented for surface adhesion control utilizing a liquid-permeable nanoporous surface, which can switch from off-state adhesion (< 0.002 kPa) to on-state attraction (0.8 kPa) without preload. The surface of the gripper is composed of vertically aligned composite nanowires with an average diameter of 79 nm. When a liquid is injected into the nanoporous membrane, capillary adhesion occurs, allowing the object to be picked up. As the liquid evaporates, the object can be released by extremely sparse contact. The off-state adhesion of a millimeter-scale gripper is even lower than the gravitational force of thin polymer films (0.18 mN cm −2 ), enabling the solid-contactless release of lightweight materials. We characterize and model the mechanism across length scales and provide pick-and-place demonstrations including LED chips, micro-architected materials, and thin-film electronics.}, archive = {J_ADVS}, author = {Seong Jae Kim and Taehoon Kim and Hyun Jun Ryu and Ji-hun Jeong and A. John Hart and Sanha Kim}, doi = {10.1002/advs.202508338}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08338}, shortjournal = {Adv. Sci.}, title = {Nanoporous capillary gripper for ultragentle micro-object manipulation}, volume = {12}, year = {2025}, }
• (2025). In situ formation of mechanically interlocked heterointerfaces with ultrahigh bonding strength for mg-based multilayered sheets. ADVS, 12(36), e08319. (www)

  @article{ , abstract = {Tailoring heterointerfaces is crucial for developing novel laminated metal composites (LMCs) with synergistic multifunctional structural properties. This study pioneers a novel approach to fabricating Mg-Ta incompatible LMCs via crystal orientation regulation, achieving in situ formed serrated mechanically interlocked interfaces with exceptional bonding strength (80.5 MPa) through hot-rolling. It also exhibits exceptional tensile properties with an ultimate tensile strength of 340–395 MPa, a yield strength of 301–363 MPa, and an elongation of 5–10.2%. Systematic multiscale investigations combining molecular dynamics (MD) simulations and density functional theory (DFT) calculations reveal a hierarchical interfacial architecture comprising dual heterointerfaces zone (hexagonal close-packed /face center cubic Mg/Cu and face centered cubic /body-centered cubic Cu/Ta), with strain-modulated micro-serrations (width: 1.6–5.5 µm; depth: 6–15 µm) morphology, along with atomic interdiffusion zones (1.1–3.1 µm). A quantifiable inverse correlation is identified between serration dimensions and interfacial strength, with reduced width and depth directly enhancing bond integrity. Furthermore, the heterointerface evolution mechanism is decoupled into three thermomechanical stages: 1) crystallographic orientation optimization via dissimilar atomic contact, 2) strain-driven micro-sawtooth generation through dislocation slip competition, and 3) geometric interlocking completion via interface self-assembly. This work establishes a universal paradigm for designing multifunctional structural materials through strain-engineered heterointerface manipulation, rather than just applying several specific deformations processes.}, archive = {J_ADVS}, author = {Zhilei Yu and Wenbo Luo and Wei Xue and Rongqin Xu and Xiuzhu Han and Zhiyong Xue and Wanshun Zhang and Hongyang Zhao and Xiaoming Cui}, doi = {10.1002/advs.202508319}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08319}, shortjournal = {Adv. Sci.}, title = {In situ formation of mechanically interlocked heterointerfaces with ultrahigh bonding strength for mg-based multilayered sheets}, volume = {12}, year = {2025}, }
• (2025). Deformation behaviors in single BCC-phase refractory multi-principal element alloys under dynamic conditions. ADVS, 12(36), e08180. (www)

  @article{ , abstract = {The mechanical behavior and microstructural evolution of a BCC-phase NbTaTiV refractory multi-principal element alloy (RMPEA) is studied over a wide range of strain rates (10 −3 to 10 3 s −1 ) and temperatures (room temperature to 850 °C). The mechanical property of present RMPEA shows less strain-rate dependence and strong resistance to softening at high temperatures. Under high strain-rate loading, the formation of thin type-I twins is observed, which could lead to an increase in strain-hardening rates. However, this hardening mechanism competes with adiabatic heating effects, resulting in the deterrence of strain-hardening behaviors. In contrast, substantial strain-hardening occurs at cryogenic temperatures due to the formation of twins, which act as stronger barriers to dislocation motion and interact with each other. To further understand the different strain-hardening behaviors, density functional theory (DFT) calculations predict relatively low stacking fault energies and high twinning stress for the NbTaTiV RMPEA.}, archive = {J_ADVS}, author = {Chanho Lee and Deva Prasaad Neelakandan and Dongyue Xie and Juntan Li and Chia-Yi Wu and Aomin Huang and Leeseung Kang and Shuozhi Xu and Barton C. Prorok and Dong-Joo Kim and Marc A. Meyers and Haixuan Xu and Peter K. Liaw and Yi-Chia Chou and Ke An and George T. Gray and Nan Li and Gian Song and Saryu J. Fensin}, doi = {10.1002/advs.202508180}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08180}, shortjournal = {Adv. Sci.}, title = {Deformation behaviors in single BCC-phase refractory multi-principal element alloys under dynamic conditions}, volume = {12}, year = {2025}, }
• (2025). Precursor inhomogeneities influence the properties of multimetal oxides as shown for LiNi0.5Mn1.5O4 derived from hydrothermally synthesized precursors. ADVS, 12(36), e08174. (www)

  @article{ , abstract = {Co-precipitation is an attractive means for synthesizing mixed metal oxides, a material class with a wide range of application prospects. Often soluble metal salts are precipitated as metal hydroxides or -carbonates, which subsequently are converted to the corresponding oxide(s) upon thermal treatment. The thermal treatment step is used to induce compositional homogeneity on the atomic level. In order to shed some more light on this effect, detailed analyses of a mixed Li-Ni-Mn-oxide with the target composition LiNi 0.5 Mn 1.5 O 4 (LNMO), which is a promising cathode material for rechargeable Li-ion batteries are performed. The first synthesis step is the precipitation of a Ni-Mn-carbonate, which is subsequently thermally lithiated and transformed into an oxide. A combination of X-Ray diffraction (XRD), Raman microscopy, scanning electron microscopy coupled with energy dispersive X-Ray spectroscopy (EDX) in combination with elemental analysis, as well as electrochemical characterization, revealed that chemical inhomogeneities present already in the precursor particles have a direct influence on the electrochemical performance of the final product. The broader implications of these results in relation to co-precipitation-based syntheses of functional materials are discussed, with special focus on the importance of the particle size distribution of the secondary particles.}, archive = {J_ADVS}, author = {Simon Schauer and Bastian Beitzinger and Gregor Neusser and Christine Kranz and Mika Lindén}, doi = {10.1002/advs.202508174}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08174}, shortjournal = {Adv. Sci.}, title = {Precursor inhomogeneities influence the properties of multimetal oxides as shown for LiNi0.5Mn1.5O4 derived from hydrothermally synthesized precursors}, volume = {12}, year = {2025}, }
• (2025). A tunable strategy for continuous production of electrolyte-free formic acid and sodium formate in a solid-state-electrolyte based electrocatalytic CO2 reduction system. ADVS, 12(36), e08152. (www)

  @article{ , abstract = {Electrocatalytic CO 2 reduction reaction (CO 2 RR) based on solid-state-electrolyte (SSE) reactors can efficiently convert CO 2 to electrolyte-free formic acid (HCOOH) solution, thereby circumventing energy-intensive downstream separation processes and further fostering the advancement of carbon-neutral technologies. However, the absence of alkali metal cations in the SSE-based CO 2 RR process at the cathode poses a challenge, constraining the performance and stability of CO 2 RR and exacerbating the hydrogen evolution side reaction. Herein, a novel strategy for the tunable production of both electrolyte-free HCOOH and sodium formate (HCOONa) solution through the regulation of anolyte composition in an SSE-based cell is reported. Employing this strategy, the continuous generation of a ≈0.27 m electrolyte-free HCOONa solution and ≈0.22 m electrolyte-free HCOOH solution with extended stabilities of 300 and 200 h, respectively is achieved. More importantly, the introduction of sodium ions resulted in a reduction of cell voltage by ≈1000 mV and further enhances the stability of the cell. In situ infrared spectroscopy and density functional theory calculations reveal that GB-Bi requires a lower applied potential for formate production, owing to its stronger binding energy to the key intermediate OCHO* compared to Bi. Finally, a techno-economic analysis indicates that this strategy for HCOONa solution production possesses excellent economic viability.}, archive = {J_ADVS}, author = {Jinrui Guo and Wenqiang Qi and Rongrong Mo and Feiyi Yuan and Lin Wang and Yongmei Li}, doi = {10.1002/advs.202508152}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08152}, shortjournal = {Adv. Sci.}, title = {A tunable strategy for continuous production of electrolyte-free formic acid and sodium formate in a solid-state-electrolyte based electrocatalytic CO2 reduction system}, volume = {12}, year = {2025}, }
• (2025). A self-powered double U-finger MME resonator capable of wirelessly capturing abnormal message in smart grid networks. ADVS, 12(36), e08149. (www)

  @article{ , abstract = {The magneto-mechano-electric (MME) coupling principle plays an important role in synchronously harvesting magnetic energy and monitoring safe operation in the distribution grid and the Power Internet of Things (PIoT). In this study, an MME resonator is presented, containing two crossed U-fingers made of piezoelectric phase-elastic beams with different lengths and magnet masses, operating in symmetric, decoupling dual bending modes. One U-finger resonating at 50 Hz serves as energy harvester (EH), while the other resonating at 185 Hz acts as current or magnetic sensor, enabling the resonator to simultaneously and wirelessly capture 50 Hz stray magnetic field ( H AC ,50 Hz ) energy and ground fault message of power lines by injecting an additional non-grid-frequency (185 Hz) current. The EH U-finger generates an output power of 1.53 mW RMS under a weak H AC ,50 Hz of only 0.5 Oe, achieving a normalized power density surpassing current standards. While the sensing U-finger shows a high sensitivity to H AC ,185 Hz with a detectability of 710 pT, even the EH U-finger is operating. The application test demonstrates the system's wireless monitoring and synchronous self-powered functions, providing stable energy for self-sensing data processing and transmission. This work introduces an efficient, wirelessly self-powered, and self-sensing method for advancements in PIoT.}, archive = {J_ADVS}, author = {Xinyi Zheng and Zhi Cheng and Bing Wang and Wei Peng and Yuelong Yu and Haoxian Peng and Yu Lei and Xiangmeng Lv and Jianglei Chang and Shitong Fang and Shuxiang Dong}, doi = {10.1002/advs.202508149}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08149}, shortjournal = {Adv. Sci.}, title = {A self-powered double U-finger MME resonator capable of wirelessly capturing abnormal message in smart grid networks}, volume = {12}, year = {2025}, }
• (2025). Unveiling charge transfer and recombination dynamics in 3D/2D heterostructure via ultrafast spectroscopy for efficient perovskite solar cells. ADVS, 12(36), e08123. (www)

  @article{ , abstract = {Charge transfer properties between 3D and 2D perovskite layers play a key role in determining the performance of 3D/2D heterostructure perovskite solar cells (PSCs). However, the exact photophysical behaviors at 3D/2D perovskite heterostructure remain ambiguous, which makes it challenging to form the desired 3D/2D heterostructure. Herein, via combining the state-of-the-art ultrafast spectroscopies of femtosecond transient absorption spectroscopy, transient absorption microscopy and time-resolved photoluminescence spectroscopy, charge transfer and recombination dynamics are unveiled at 3D/2D perovskite heterostructure, for comparison, where the 2D layers are fabricated through the two distinct approaches of organic ligand surface reaction (2D L ) and 2D crystal seed direct deposition (2D S ), respectively. 3D/2D S heterostructure exhibits superior hole transfer from 3D to 2D S , featuring a large spatial diffusion constant and high charge mobility compared to 3D/2D L , attributed to the higher phase purity and the lower defects in 2D S . Moreover, 3D/2D S heterostructure yields suppressed nonradiative recombination, reduced Langevin recombination, and increased quasi-Fermi level splitting, significantly aiding fast photoinduced charge transfer at such heterostructure. These advantages are further confirmed by a remarkably improved PSC efficiency using 3D/2D S , especially in terms of enhanced open-circuit voltage and diminished energy loss. This work sheds light on the dynamics at 3D/2D heterostructures, providing a promising guideline for designing 3D/2D high-performance PSCs.}, archive = {J_ADVS}, author = {Di Li and Junhan Xie and Shaobing Xiong and Xiaoxiao Zang and Zhennan Lin and Yuning Wu and Weimin Liu and Bo Li and Zhenrong Sun and Junhao Chu and Qinye Bao}, doi = {10.1002/advs.202508123}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08123}, shortjournal = {Adv. Sci.}, title = {Unveiling charge transfer and recombination dynamics in 3D/2D heterostructure via ultrafast spectroscopy for efficient perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Personalized neoantigen vaccine plus regorafenib increases Rgs2⁺CD8⁺ t cells infiltration and reprograms the tumor microenvironment in microsatellite stable colorectal cancer liver metastases. ADVS, 12(36), e08040. (www)

  @article{ , abstract = {Microsatellite stable colorectal cancer liver metastases (MSS-CRLM) resist immune checkpoint inhibitors due to their immunosuppressive tumor microenvironment (TME) and low mutation burden (TMB). A personalized neoantigen vaccine, Neo-CRCVAS, using whole-exome and RNA sequencing of murine MSS-CRC cells, comprising 7 immunogenic neoantigen peptides with Poly(I:C) is developed and combined with regorafenib as a novel therapy (RegoNeo). In MSS-CRLM mouse models, RegoNeo significantly enhanced tumor regression and survival while establishing durable immune memory. Single-cell RNA and TCR sequencing revealed that RegoNeo expanded a distinct Rgs2⁺CD8⁺ T cell population with strong cytotoxic activity and TCR clonal expansion. These Rgs2⁺CD8⁺ T cells, enriched for neoantigen-specific T cells, demonstrated potent tumor-killing capabilities in both mouse models and patient-derived organoids. The findings establish RegoNeo as a promising personalized immunotherapy that reprograms the immunosuppressive tumor microenvironment by increasing Rgs2⁺CD8⁺ T cell infiltration, highlighting both the treatment approach and this specific T cell subset as potential therapeutic targets for MSS-CRLM patients.}, archive = {J_ADVS}, author = {Hengkai Chen and Bin Chen and Yuanfeng Yang and Shoufeng Li and Huajun Cai and Zhicheng Zhuang and Yong Wu and Yuan Gao and Yupeng Chen and Xing Liu and Guoxian Guan and Jinfu Zhuang}, doi = {10.1002/advs.202508040}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e08040}, shortjournal = {Adv. Sci.}, title = {Personalized neoantigen vaccine plus regorafenib increases Rgs2⁺CD8⁺ t cells infiltration and reprograms the tumor microenvironment in microsatellite stable colorectal cancer liver metastases}, volume = {12}, year = {2025}, }
• (2025). Heme/NADH mimics co-decorated allosteric capsules for regulating oxygen activation and upregulating intracellular methionine depletion. ADVS, 12(36), e07850. (www)

  @article{ , abstract = {Stimuli-responsive behaviors in living bodies provide the fundamental principles for developing switchable architectures that apply to the direct function regulation. Herein, by incorporating both the µ -oxo bridged Fe III -porphyrins and NADH (nicotinamide adenine dinucleotide) mimics into an allosteric coordination capsule, the regulation of O 2 activation and the upregulation of intracellular methionine depletion have been achieved, resulting in effective pH-activated tumor immunotherapy. Upon light irradiation, the transition from the tensed bridged Fe III -porphyrins to the relaxed unbridged Fe IV = O/Fe II porphyrin pair induces unique conformational switching. The relaxed state of the capsule facilitates the binding of substrates for the oxygen atom transfer reaction. The in situ formed Fe II -porphyrin pair, following the substrate oxygenation, activates O 2 with the intervention of NADH mimics to restore the tensed state of the capsule, thereby releasing the product for the next cycle. Regulated by the acid/base content in the system, this allostery-triggered metabolic behavior enhances the efficacy of intracellular methionine depletion therapy through the accumulation of local methionine sulfoxide, thereby improving safety. The allosteric switching strategy offers an improved approach for precise tumor treatment via dual light-and-guest stimuli-responsive regulation.}, archive = {J_ADVS}, author = {Chunming Ma and Yihao Zhang and Junkai Cai and Baotong Ding and Yang Jiao and Chunying Duan}, doi = {10.1002/advs.202507850}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07850}, shortjournal = {Adv. Sci.}, title = {Heme/NADH mimics co-decorated allosteric capsules for regulating oxygen activation and upregulating intracellular methionine depletion}, volume = {12}, year = {2025}, }
• (2025). Electrochemical CO2 reduction on janus dual-atom catalysts: Critical role of oxygen coordination and an effective descriptor. ADVS, 12(36), e07849. (www)

  @article{ , abstract = {Dual-atom catalysts (DACs) embedded in nitrogen-doped graphene have been widely studied for electrochemical CO 2 reduction (CO 2 R), primarily yielding CO. However, achieving selectivity for C1 hydrocarbons remains challenging. Here, 32 Janus DACs (J-M'M) are designed and investigated for CO 2 R using density functional theory (DFT) calculations, identifying 13 capable of producing methanol and methane. Notably, J-FeCo and J-CoNi exhibit favorable limiting potentials (−0.38 and −0.45 V vs. RHE) for CH 3 OH and CH 4 production, respectively, based on constant-potential calculations. Compared to normal DACs (N-M'M), Janus DACs demonstrate enhanced initial CO 2 hydrogenation and stronger CO adsorption. Oxygen coordination in J-FeCo and J-CoNi induces a downshift/upshift of majority-/minority-spin energy levels of d z2 , d yz , and d xz orbitals toward the Fermi level relative to N-FeCo and N-CoNi, strengthening the bonding state and weakening the antibonding state, thereby improving CO adsorption. Furthermore, an effective descriptor based on atomic features is identified to evaluate *CO binding strength. This work highlights the critical role of partial oxygen coordination in DACs for C1 hydrocarbons production and proposes a robust descriptor to guide the design of related catalysts.}, archive = {J_ADVS}, author = {Hongling Liu and Zhichao Yu and Jia Zhao and Weng Fai Ip and Sen Lin and Hui Pan}, doi = {10.1002/advs.202507849}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07849}, shortjournal = {Adv. Sci.}, title = {Electrochemical CO2 reduction on janus dual-atom catalysts: Critical role of oxygen coordination and an effective descriptor}, volume = {12}, year = {2025}, }
• (2025). Semi-crystalline ruthenium catalyst for zero-drag hydrogen production from hybrid alkaline seawater electrolysis. ADVS, 12(36), e07848. (www)

  @article{ , abstract = {Hydrazine-assisted hybrid alkaline seawater electrolysis offers a dual-functional platform for environmentally benign remediation of toxic hydrazine and energy-autonomous hydrogen generation. Addressing the critical need for simplified system integration, a single-metal bifunctional catalyst is developed by modulating electronic metal-support interactions (EMSI) to construct semi-crystalline Ru domains with metastable crystalline-amorphous interfaces. The optimized catalyst achieves ultralow overpotentials of 21.5 mV (hydrogen evolution) and 254 mV (hydrazine oxidation) at 10 mA cm⁻ 2 , alongside spontaneous hydrazine decomposition at open-circuit potential. This synergy enables near-zero energy input for electrolysis, evidenced by a steep polarization slope (1.235 A cm⁻ 2 V⁻¹), which surpasses conventional hybrid systems. Density functional theory (DFT) calculations reveal that amorphous Ru sites near the interface induce charge redistribution, which partially optimizes the free energy changes associated with adsorption * H and the dehydrogenation process from * N₂H₄ to * N₂H₃. This is accompanied by a transformation of the rate-determining step into the * N₂H → * N₂ pathway, thereby advancing the kinetics of the bifunctional hydrogen evolution reaction/hydrazine oxidation reaction (HER/HzOR) reactions. The work redefines catalyst design paradigms by leveraging interfacial metastability, bridging pollutant elimination with high-efficiency hydrogen economies.}, archive = {J_ADVS}, author = {Dongquan Yang and Rui Yang and Huayi Zeng and Jiajun Luo and Shuangjuan Shen and Yiyin Huang and Yuanyuan Sun}, doi = {10.1002/advs.202507848}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07848}, shortjournal = {Adv. Sci.}, title = {Semi-crystalline ruthenium catalyst for zero-drag hydrogen production from hybrid alkaline seawater electrolysis}, volume = {12}, year = {2025}, }
• (2025). Spatiotemporal transcriptomic atlas reveals the regulatory mechanisms underlying early inflorescence development and sex differentiation in spinach. ADVS, 12(36), e07818. (www)

  @article{ , abstract = {Dioecious plant species produce male and female flowers on separate individuals. However, the molecular regulatory mechanisms underlying these processes remain poorly understood. In this study, the model dioecious spinach ( Spinacia oleracea ), a widely cultivated leafy vegetable, is investigated by analyzing spatial transcriptomes of the shoot apices at different developmental stages. The findings elucidate key regulatory pathways underlying both inflorescence development and sex differentiation. Through the characterization of dynamic transcriptional changes across four consecutive developmental phases, distinct cell types within the shoot apex and stage-specific marker genes are identified. Notably, pseudotime trajectory analysis reveals that spinach sex differentiation occurs at the four-leaf stage. Furthermore, the critical involvement of epigenetic mechanisms in this process is demonstrated. By integrating functional genetic validation, the epigenetic regulator MULTICOPY SUPPRESSOR OF IRA 1 (MSI1) together with histone deacetylase HDT2 is discovered to promote female differentiation. Collectively, this work provides comprehensive insights into the regulatory networks controlling inflorescence development and sexual differentiation in spinach and establishes a valuable resource for advancing sex differentiation research in dioecious plants.}, archive = {J_ADVS}, author = {Chen You and Hao Yang and Yueyan Zhao and Xiaoning Wang and Shuaijie Wei and Ning Chen and Yulan Zhang and Luxian Liu and Wei Qian and Shufen Li and Wujun Gao}, doi = {10.1002/advs.202507818}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07818}, shortjournal = {Adv. Sci.}, title = {Spatiotemporal transcriptomic atlas reveals the regulatory mechanisms underlying early inflorescence development and sex differentiation in spinach}, volume = {12}, year = {2025}, }
• (2025). Achieving anti-disproportionation performance enhancement and distorted inverse-disproportionation reaction correction of Zr2Fe-based hydrogen isotope storage alloys via element substitution. ADVS, 12(36), e07722. (www)

  @article{ , abstract = {Zr 2 Fe alloy is a promising candidate as a tritium-getter material for the International Thermonuclear Experimental Reactor (ITER), but its practical application is hindered by undesirable inverse disproportionation behavior and poor anti-disproportionation properties. In this study, theoretical computational screening is utilized to predict the effects of partially substituting Fe with Co, Cu, and Ni on regulating the Zr 2 Fe 1-x M x (M = Co, Cu, Ni; x = 0.1–0.5) hydrogen storage systems. Experimentally, these modifications successfully correct the distorted inverse disproportionation reaction and achieve full reversibility in the Zr 2 Fe 1-x M x- H systems. Notably, Zr 2 Fe 0.8 Cu 0.2 and Zr 2 Fe 0.7 Ni 0.3 alloys retain excellent hydrogen storage properties, while their kinetic energy barriers of hydriding disproportionation reaction increase significantly from 87.88 kJ mol −1 (Zr 2 Fe) to 184.35 kJ mol −1 (Zr 2 Fe 0.8 Cu 0.2 ) and 192.32 kJ mol −1 (Zr 2 Fe 0.7 Ni 0.3 ), respectively. The corresponding deceleration of hydriding disproportionation kinetics behaviors is clearly visualized by TEM observations. Combined density functional theory analyses reveal that the mechanism underlying enhanced anti-disproportionation properties in the optimized Zr 2 Fe 1-x M x- H systems involves the homogenization and stabilization of Zr─H bonds within the hydrogen storage interstices, along with the effective suppression of disproportionation-favorable chemical environments.}, archive = {J_ADVS}, author = {Zhiyi Yang and Yuxiao Jia and Yang Liu and Fei Chu and Jiacheng Qi and Tiao Ying and Jiahuan He and Xingwen Feng and Jiangfeng Song and Yan Shi and Wenhua Luo and Xuezhang Xiao and Lixin Chen}, doi = {10.1002/advs.202507722}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07722}, shortjournal = {Adv. Sci.}, title = {Achieving anti-disproportionation performance enhancement and distorted inverse-disproportionation reaction correction of Zr2Fe-based hydrogen isotope storage alloys via element substitution}, volume = {12}, year = {2025}, }
• (2025). Lipid-based nanoparticles in cancer therapy: Advances in targeted drug delivery and therapeutic potential for renal cell carcinoma. ADVS, 12(36), e07666. (www)

  @article{ , abstract = {Renal cell carcinoma (RCC) remains a significant clinical challenge due to delayed diagnosis and multidrug resistance, necessitating innovative strategies to enhance early detection and therapeutic efficacy. This review evaluates the role of lipid-based nanoparticles (LNPs), including liposomes, micelles, nanoemulsions, solid lipid nanoparticles, and nanostructured lipid carriers, as advanced drug delivery systems in providing innovative solutions for RCC diagnosis and treatment. These LNPs exhibit unique advantages of great biocompatibility, biodegradability, extended circulation, and tumor-targeting capabilities, which enable precise drug delivery, controlled release, and circumvention of drug resistance mechanisms. After integrating recent advancements, it is highlighted that formulations such as Liposome@Sunitinib can enhance tumor accumulation, two-drug-loaded liposomes can activate immune responses, and RNA therapy in combination with immunomodulators can reverse drug resistance. Current findings underscore the transformative potential of lipid-based nanotechnology in addressing RCC-specific challenges, particularly in overcoming biological barriers and refining personalized treatment approaches. In the future, multifunctional nano platforms, precision therapies based on patient genes, advanced materials engineering, combination therapies, and sustainable manufacturing can be developed to promote the application of LNPs in the treatment of RCC and realize personalized nanomedicine.}, archive = {J_ADVS}, author = {Wei Yao and Yuhe Lin and Yang Weng and Yan Wu and Lufeng Zheng and Donghan Zheng and Qi Xi and Jingying Zhao}, doi = {10.1002/advs.202507666}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07666}, shortjournal = {Adv. Sci.}, title = {Lipid-based nanoparticles in cancer therapy: Advances in targeted drug delivery and therapeutic potential for renal cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Suppressing ion migration in heterostructure single crystals for highly sensitive ultra-stable X-ray detection. ADVS, 12(36), e07588. (www)

  @article{ , abstract = {Heterostructure single crystals have emerged as a significant functional material system due to their unique properties and potential for novel optoelectronic device applications. Particularly, their distinctive structural characteristics offer promising prospects for suppressing ion migration, which is highly advantageous for X-ray detection. Herein, by gradually modifying the cyclohexylmethylamine cation into the 4-aminomethyltetrahydropyran cation, a layered heterostructure single crystal (PbCl 2 ) 2 (4-Aminomethyltetrahydropyran) 2 PbCl 4 is successfully obtained. It comprises two distinct inorganic frameworks, namely a perovskite layer built from PbCl₆ octahedra and an intergrowth layer consisting of PbCl₂ units, wherein the organic components are firmly anchored to the intergrowth layer via Pb─O bonds, thereby enhancing the crystal stability and effectively suppressing ion migration, as evidenced by high ion migration activation energy (1.64 eV) and extremely low dark current drift (2.86 × 10 −18 A cm −1 V −1 s −1 ). X-ray devices based on the ultra-stable heterostructure single crystal demonstrate an extraordinary sensitivity of 8453.3 µC Gy −1 cm −2 (at 40 V), ultra-low detection limit of 5.2 nGy s −1 and superior air stability (≈1 year). Such values make it one of the most outstanding candidates for high-performance X-ray detection. This work promotes the development of heterostructure single crystals optoelectronic applications.}, archive = {J_ADVS}, author = {Yu Ma and Wenjing Li and Yi Liu and Wuqian Guo and Haojie Xu and Liwei Tang and Qingshun Fan and Linjie Wei and Junhua Luo and Zhihua Sun}, doi = {10.1002/advs.202507588}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07588}, shortjournal = {Adv. Sci.}, title = {Suppressing ion migration in heterostructure single crystals for highly sensitive ultra-stable X-ray detection}, volume = {12}, year = {2025}, }
• (2025). Photodegradation of 2D ruddlesden-popper perovskites: Consequences and design principles for photoelectrochemical applications. ADVS, 12(36), e07300. (www)

  @article{ , abstract = {Halide perovskites (HaP), with their exceptional optoelectronic properties and high-power conversion efficiencies in photovoltaic devices, hold promise for photoelectrochemical (PEC) applications in green fuel and chemical production. However, their stability in aqueous environments remains a challenge. This study investigates the stability and degradation mechanisms of the 2D Ruddlesden-Popper phase phenylethyl ammonium lead iodide (PEA (+) 2 PbI 4 ) thin films in aqueous electrolytes under dark and illuminated conditions. While PEA (+) 2 PbI 4 thin films appear to be thermodynamically stable in an aqueous electrolyte with phenylethyl ammonium iodide (PEAI), illumination causes significant photodegradation generating a deprotonated and dehalogenated 2D intercalation product: phenylethylamine-lead iodide, 2PEA (0) -PbI 2 . The degradation of the 2D semiconductor leads to substantial reduction in the photovoltage, adversely impacting the material performance in photoelectrochemical (PEC) devices. To intercept photo-excited charge carriers in the 2D semiconductor, the I 3 − /I − redox is added, which reduced photodegradation. The findings underscore that while catalytic reactions at halide perovskite electrodes in aqueous electrolytes are feasible, reversible and irreversible photodegradation remains a critical limitation that must be addressed in the design of PEC devices employing metal halide semiconductor layers for direct electrochemical energy conversion.}, archive = {J_ADVS}, author = {Manuel F. Vasquez-Montoya and Maxim Simmonds and Jinzhao Li and Anton Dzhong and Thomas W Gries and Arsene Chemin and Tristan Petit and Philippe Holzhey and Steve Albrecht and Sergei Trofimov and Boris Naydenov and Roel Van de Krol and Marco Favaro and Eva Unger}, doi = {10.1002/advs.202507300}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07300}, shortjournal = {Adv. Sci.}, title = {Photodegradation of 2D ruddlesden-popper perovskites: Consequences and design principles for photoelectrochemical applications}, volume = {12}, year = {2025}, }
• (2025). Topological singularities and edge-state coupling enable robust on-chip slow light. ADVS, 12(36), e07226. (www)

  @article{ , abstract = {Quantum interference (QI) between multiple excitation pathways can manipulate high-quality optical responses, like slow light, highly-sensitive sensors, and ultrafast switches. However, the enhanced light-matter interactions and reduced group velocity tend to arouse high sensitivity to the environment, challenging fabrication and operation in practical applications. In this work, the first experimental demonstration of topological QI-like effect is reported in a 1D on-chip system, where two different topological mechanisms are induced to provide robustness for slow light. Topological charges rooted in the parameter space can offer immunity to parameter deviations, such as coupling strengths, and topological edge states rooted in the momentum space can manifest robustness against structural disturbances, like width disorders and bending deformations. By incorporating bright and dark edge states into a composite waveguide, the electromagnetically induced transparency (EIT) window is observed and switching between slow light and fast light is demonstrated by measuring the transmission and group delays. The findings provide an extensible platform for exploring novel QI and topological physics, and pave the avenue for developing robust on-chip devices.}, archive = {J_ADVS}, author = {Yuqian Wang and Shengyu Hu and Zhiwei Guo and Jie Jiang and Yaping Yang and Cuicui Lu and Hong Chen}, doi = {10.1002/advs.202507226}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07226}, shortjournal = {Adv. Sci.}, title = {Topological singularities and edge-state coupling enable robust on-chip slow light}, volume = {12}, year = {2025}, }
• (2025). Engineered anti-senescence trachea with post-transplanted regenerative homeostasis. ADVS, 12(36), e07186. (www)

  @article{ , abstract = {Post-transplanted dysfunction remains the key unsolved challenge to construct bioengineered complex organs. Herein, by analyzing the bioengineered trachea, it is found that multiple tissue senescences occur, and poor endogenous cellular contact and exogenous immune microenvironment dysregulation are identified as two crucial factors during senescence. Therefore, a Hebe engineered trachea (Hebe-ET) with a ring–ring structure and dual anti-senescence designs is proposed for maintaining regenerative homeostasis after transplantation. First, in the cartilage rings, a fiber-film structural scaffold is designed to promote close-packed cellular contact, significantly reducing senescent P21+ chondrocytes. Furthermore, between the cartilage rings are distributed fibrous connective tissue rings, in which the loaded quercetin induces an immune cascade to restrain senescence in multiple cells, including chondrocytes, endothelial cells, and fibroblasts via mitochondrion-targeted oxidative stress scavenging, promoting the development of the full tracheal components in vivo. Based on these designs, 12 weeks after orthotopic transplantation, the Hebe-ET achieves sustainable youth and develops a natural-like structure with mature cartilage phenotype, reconstructed vascular network, and epithelium coverage. The mechanical property exceeds that of the natural trachea, and 87.5% of animals survived. This study first reveals the necessity of anti-senescence design in the fabrication of complex organ substitutes and proposes an effective engineering strategy for segmental trachea reconstruction.}, archive = {J_ADVS}, author = {Ziyin Pan and Hai Tang and Lanlan Wang and Qingfeng Bai and Yi Chen and Runfeng Cao and Weikang Lin and Lei Wang and Yulong Hu and Guofang Zhao and Minglei Yang and Weiyan Sun and Kun Zhang and Dawei Li and Chang Chen}, doi = {10.1002/advs.202507186}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07186}, shortjournal = {Adv. Sci.}, title = {Engineered anti-senescence trachea with post-transplanted regenerative homeostasis}, volume = {12}, year = {2025}, }
• (2025). Modulating Macrophage–Nucleus pulposus cell crosstalk via sequential drug delivery attenuates disc degeneration. ADVS, 12(36), e07178. (www)

  @article{ , abstract = {Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM). Improving nucleus pulposus cells (NPCs) condition first requires a supportive surrounding environment. However, how to provide an excellent microenvironment before regulating the function of the NPCs is not yet a complete strategy. In this study, a sequential drug delivery system is comprised of chitosan hydrogel (G-CS) loaded with Angiotensin (1-7) and mesoporous silica nanospheres (MSN) coating with α-mangostin to achieve synergistic effects of anti-inflammatory and regulation of metabolic disorders of the ECM in NPCs. The system first explosively releases outer G-CSloaded Angiotensin (1-7) by exploiting the different solubility characteristics of the two drugs, which improves the inflammatory environment by inhibiting the integrated stress response and regulating the macrophage phenotype. During the second stage, the inner layer of the MSN controlled-release loaded α-mangostin to regulate ECM metabolism and synthesis, slowing cell aging and apoptosis. Furthermore, α-mangostin promotes mitophagy in NPCs by inhibiting the PI3K/AKT/mTOR pathway and activating the Pink1/Parkin pathway, promoting the clearance of damaged mitochondria. The proposed drug delivery system represents an innovative and promising strategy for treating IDD.}, archive = {J_ADVS}, author = {Xiangzhen Kong and Rui Hu and Peng Zhang and Qi Li and Kangle Song and Hanwen Gu and Jihui Zheng and Shen Liu and Liang Liu and Lin Jin and Lei Cheng and Chengwei Li and Zhijian Wei}, doi = {10.1002/advs.202507178}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07178}, shortjournal = {Adv. Sci.}, title = {Modulating Macrophage–Nucleus pulposus cell crosstalk via sequential drug delivery attenuates disc degeneration}, volume = {12}, year = {2025}, }
• (2025). Zwitterion-stabilized superlattices and frank-kasper phases in charged block copolymers for mechanically robust dielectric soft materials. ADVS, 12(36), e07115. (www)

  @article{ , abstract = {Superlattice structures, created by the periodic arrangement of two or more distinct materials, have attracted significant interest. This paper proposes a strategy for designing superlattice structures in soft materials with improved dielectric and mechanical properties. Two types of acid-functionalized block copolymers and a series of zwitterions with varying cationic and anionic structures are synthesized. When the zwitterion anion possesses a localized charge and the cation exhibits weak interactions with the acid groups in the polymers, the zwitterions preferentially localize at the interfacial layers between the ionic and ionophobic domains. As the zwitterion concentration increases and ion–dipole interactions strengthen within the confined subdomains, the interfacial curvature of the superlattice transitions from lamellae to cylindrical morphology and further evolves to Frank-Kasper phases. Notably, these morphological transitions occur despite the symmetrical volume fractions of the ionic phases. These superlattice structures and Frank-Kasper phases exhibit thermal stability up to 150 °C, a high static dielectric constant of 25, and excellent mechanical properties including a modulus of 360 MPa, hardness of 16 MPa, stiffness of 772 N m −1 , and energy dissipation index of 0.675 at 22 °C, making them highly promising candidates for advanced applications in soft electronics and memory devices.}, archive = {J_ADVS}, author = {Jaemin Min and Hojun Lee and Moon Jeong Park}, doi = {10.1002/advs.202507115}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07115}, shortjournal = {Adv. Sci.}, title = {Zwitterion-stabilized superlattices and frank-kasper phases in charged block copolymers for mechanically robust dielectric soft materials}, volume = {12}, year = {2025}, }
• (2025). Interfacial roughness-reinforced magnetic nanosheet colloidal gels for stable embolization and magnetothermal therapy of hepatic tumor. ADVS, 12(36), e07096. (www)

  @article{ , abstract = {Injectable hydrogels have been developed for transcatheter arterial embolization (TAE) of hepatic tumor owing to their flexibility in injection and embolization. However, the dual requirement for high mechanical robustness and good injectability poses a fundamental challenge, as improvements in one often compromise the other. Colloidal gels offer tunable mechanical properties and feasible injectability through the bottom-up assembly of building blocks. Here an interfacial reinforcement strategy is developed by enhancing specific surface area and roughness to fabricate nanosheet-mica (NM) magnetic colloidal gels (NMMG). The negatively charged NM, exfoliated from natural ground mica (GM), possessed increased binding sites, while in situ grown Fe 3 O 4 nanoparticles enhanced building block roughness, reducing intergranular displacement and thereby maintaining mechanical strength while ensuring injectability. Compared with GM-based magnetic colloidal gels, NMMG can be injected through 2.6 F catheter with ≈20 N force (40% of manual limit), while storage modulus improved from ≈800 to ≈1800 Pa (2.25-fold higher than embolization minimum limit). Transcatheter embolization with NMMG significantly inhibited tumor growth. Furthermore, NMMG-mediated minimally invasive therapies, including TAE combined with magnetothermal therapy, achieved synergistic therapeutic effects in hepatic tumor-bearing rabbits. The rough-interface strengthening strategy facilitates the development of high-performance colloidal gels with mechanical integrity and tailored functions.}, archive = {J_ADVS}, author = {Xingyu Liu and Sheng Chen and Yonghong Song and Bing Chen and Xu Yan and Rui Qiu and Jinlong Hu and Baoqiang Cao and Hanye Xing and Tao Zhou and Liang Dong and Yang Lu}, doi = {10.1002/advs.202507096}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07096}, shortjournal = {Adv. Sci.}, title = {Interfacial roughness-reinforced magnetic nanosheet colloidal gels for stable embolization and magnetothermal therapy of hepatic tumor}, volume = {12}, year = {2025}, }
• (2025). Realization of spin-locked acoustic helical landau levels in both hexagonal and square lattices. ADVS, 12(36), e07059. (www)

  @article{ , abstract = {Topological zeroth-order Landau levels offer a promising avenue for steering acoustic and electromagnetic waves. However, the helical Landau levels in 2D acoustic systems remain an unresolved challenge. Moreover, previous studies on zeroth-order Landau levels have primarily focused on hexagonal lattices, leaving their counterparts in square lattices largely unexplored. In this study, the helical Landau levels rooted in acoustic quantum spin Hall systems are theoretically proposed and experimentally validated. By linearly increasing the local bandgap through the lifting of the double Dirac cone in acoustic crystals with both square and hexagonal lattices—achieved via topology optimization method—a position-dependent effective mass is introduced in the Dirac Hamiltonian, thereby synthesizing in-plane pseudomagnetic fields. This results in the emergence of spin-locked helical Landau levels, which has been experimentally validated. The large-area conveyance of acoustic energy facilitated by these helical Landau levels is demonstrated and the robustness of Landau-level-mediated propagation against defects is confirmed. A new pathway for exploring acoustic helical Landau levels based on spin Hall physics is opened.}, archive = {J_ADVS}, author = {Yafeng Chen and Zhihao Lan and Shanjun Liang and Lei Fan and Jie Zhu and Zhongqing Su}, doi = {10.1002/advs.202507059}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e07059}, shortjournal = {Adv. Sci.}, title = {Realization of spin-locked acoustic helical landau levels in both hexagonal and square lattices}, volume = {12}, year = {2025}, }
• (2025). Anticrossing of a plasmonic nanoresonator mode and a single quantum dot at room temperature. ADVS, 12(36), e06676. (www)

  @article{ , abstract = {Strong coupling between a single quantum emitter and a resonant plasmonic mode at room temperature is vital for quantum information processing and sensing. Beating dephasing in these systems by ultrafast energy transfer requires coupling single emitters to a plasmonic nanoresonator with ultrasmall mode volume and optimal spectral overlap. Typically, strong coupling is inferred from normal mode splittings in luminescence spectra, offering rough estimates of coupling strength. However, achieving a full anticrossing and characterizing uncoupled components in advance is challenging. Here, the oxygen-dependent blue-shift of CdSe/ZnS quantum dots, recorded at 33 ms time resolution, is leveraged to deterministically tune their transition energy across a scanning plasmonic slit resonator to yield a complete anticrossing, after characterizing both uncoupled states beforehand. The findings provide clear evidence of strong coupling at room temperature, with a Rabi splitting at zero detuning of , consistent with theoretical modeling. This work advances the development of deterministic plexitonic devices utilizing single-photon nonlinearities at ambient conditions.}, archive = {J_ADVS}, author = {Daniel Friedrich and Jin Qin and Benedikt Schurr and Tommaso Tufarelli and Heiko Groß and Bert Hecht}, doi = {10.1002/advs.202506676}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06676}, shortjournal = {Adv. Sci.}, title = {Anticrossing of a plasmonic nanoresonator mode and a single quantum dot at room temperature}, volume = {12}, year = {2025}, }
• (2025). Topological vulcanization strategy for elastomeric electrolytes with enhanced mechanical and electrochemical properties for advanced lithium metal batteries. ADVS, 12(36), e06640. (www)

  @article{ , abstract = {Elastomeric electrolytes (EEs) have garnered significant attention in the realm of next-generation energy storage systems, attributed to their distinctive mechanical properties. Nonetheless, achieving precise modulation of mechanical robustness while ensuring efficient lithium-ion transport continues to present a significant challenge. In this study, an innovative topological vulcanization strategy is proposed to fabricate uniformly crosslinked EEs. The resultant EEs demonstrate exceptional mechanical properties, characterized by a tensile strength of 3.51 MPa and an elongation at break of 832%, alongside a room-temperature ionic conductivity of 4 × 10 −4 S cm −1 . Such robust and flexible electrolytes maintain superior structural integrity throughout battery operation. This approach enables stable cycling for more than 3000 h in lithium symmetric cells and achieves 95.7% capacity retention after 500 cycles at a rate of 0.5C in full cells. They also exhibit consistent and dependable performance in stretchable and pouch cells even under significant deformations, thereby confirming their suitability for advanced flexible energy storage applications.}, archive = {J_ADVS}, author = {Na Yang and Haotian Meng and DeCai Guo and Yongyi Song and Yongzheng Shi and Jin Niu and Feng Wang}, doi = {10.1002/advs.202506640}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06640}, shortjournal = {Adv. Sci.}, title = {Topological vulcanization strategy for elastomeric electrolytes with enhanced mechanical and electrochemical properties for advanced lithium metal batteries}, volume = {12}, year = {2025}, }
• (2025). Sustainable electrochemical strategy for selective double bond oxidation in the presence of aldehyde groups with Mo─N─O catalysts. ADVS, 12(36), e06584. (www)

  @article{ , abstract = {Selective oxidation of double bonds in aldehyde-containing molecules is critical for synthesizing multifunctional organic compounds; however, conventional methods struggle to preserve aldehyde integrity due to competitive over-oxidation. Here, an electrochemical strategy is presented that achieves precise double bond oxidation without aldehyde degradation, using hydroperoxyl radicals ( * OOH) generated by a molybdenum-based catalyst (Mo─N─O). Under mild, energy-efficient conditions (−200 mA), this approach converts cinnamaldehyde to benzaldehyde with complete conversion (100%) and >99% selectivity, outperforming traditional harsh oxidants. Mechanistic analysis reveals that the tailored coordination environment of the catalyst enhances * OOH formation, enabling targeted oxidative activity. The method operates at ambient conditions, eliminates toxic reagents and high energy-consuming process, and aligns with sustainable chemistry principles. By integrating electrocatalysis with insights from density functional theory, the study establishes a scalable platform for the precise transformation of multifunctional organic molecules, representing a significant step forward in energy-efficient chemical synthesis.}, archive = {J_ADVS}, author = {Zhirong Li and Xun Zhang and Jiao Liu and Zhaomin Hao and Tengfei Zhang and Yang Yang and Yitong Wang and Santhosh Kamaraj and Jianrong Zeng and Qingsong Dong and Cuiping Zhai and Wuping Liao and Shuyan Song}, doi = {10.1002/advs.202506584}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06584}, shortjournal = {Adv. Sci.}, title = {Sustainable electrochemical strategy for selective double bond oxidation in the presence of aldehyde groups with Mo─N─O catalysts}, volume = {12}, year = {2025}, }
• (2025). A phase separation-assisted pre-enrichment method for ultrasensitive respiratory virus detection. ADVS, 12(36), e06578. (www)

  @article{ , abstract = {Enriching trace biomarkers (e.g., proteins, nucleic acids) is critical for biomedical applications; yet conventional methods often lack versatility, limiting their effectiveness to specific biomarker types. To address this, the phase separation-assisted pre-enrichment (PSAP) technology is presented that exploits differential polymer-polymer partitioning to achieve 47-fold antigen and 44-fold RNA enrichment simultaneously. Through systematic optimization of interfacial chemistry, including pH modulation, polymer hydrophilicity, mass fraction, and molecular weights, the protocol is refined to enable direct integration with commercial diagnostics. PSAP-boosted rapid antigen ests (RATs) detected SARS-CoV-2 and Influenza viruses at tenfold and fivefold lower limits, respectively. In clinical validation, 53 clinical specimens (containing PCR undetectable samples as controls) are analyzed. The PSAP method significantly enhanced detection accuracy for both viral antigens and RNA, particularly improving positivity rates in low viral load specimens (27 < Ct < 31) compared to conventional approaches while maintaining specificity in high-Ct and negative controls. With its universality and tunability, PSAP demonstrates universal applicability across respiratory pathogens and lays the foundation for next-generation point-of-care diagnostics.}, archive = {J_ADVS}, author = {Yang Cao and Pui Ngan Lau and Alex W.H. Chin and Zhuolin He and Christina C. K. Au Yeung and Kehao Zeng and Haisong Lin and Leo L. M. Poon and Ho Cheung Shum}, doi = {10.1002/advs.202506578}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06578}, shortjournal = {Adv. Sci.}, title = {A phase separation-assisted pre-enrichment method for ultrasensitive respiratory virus detection}, volume = {12}, year = {2025}, }
• (2025). A network-driven framework for drug response precision prediction of acute myeloid leukemia. ADVS, 12(36), e06447. (www)

  @article{ , abstract = {Acute myeloid leukemia (AML) is a clonal malignancy of myeloid progenitor cells that demonstrates highly variable responses to current regimens, highlighting the need for precision medicine. However, reliable biomarkers for precision medicine treatment remain elusive due to cellular heterogeneity. Conventional Models based on bulk RNA sequencing and ex vivo assays often fail to capture the intricate molecular pathways and gene networks that underlie treatment response and resistance. Here, NetAML, a novel network-based precision medicine platform that systematically develops 87 drug sensitivity prediction models for 87 clinical drugs using ex vivo drug responses from 520 AML patients with RNA-Seq is presented. The approach leverages network-based analysis and machine learning to identify biologically interpretable gene signatures that capture the complex molecular interactions driving differential drug responses. Notably, the signature genes derived from the models reveal distinct cellular mechanisms. For instance, the co-expression of C19ORF59 and FLT3 is associated with resistance to FLT3 inhibitors. In summary, NetAML offers a powerful strategy for personalized AML treatment by constructing drug-specific models, identifying clinically actionable biomarkers, and supporting the development of optimized, patient-specific therapeutic regimens.}, archive = {J_ADVS}, author = {Yinyin Wang and Rui Liu and Yinnan Zhang and Xiang Luo and Chengzhuang Yu and Shentong Fang and Ninghua Tan and Jing Tang}, doi = {10.1002/advs.202506447}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06447}, shortjournal = {Adv. Sci.}, title = {A network-driven framework for drug response precision prediction of acute myeloid leukemia}, volume = {12}, year = {2025}, }
• (2025). Tendinopathy: The interplay between mechanical stress, inflammation, and vascularity. ADVS, 12(36), e06440. (www)

  @article{ , abstract = {Tendinopathy is a long-lasting, debilitating disease that not only affects patients' individual lives, but also imposes a significant socioeconomic burden. Due to an insufficient understanding of the underlying pathomechanisms, treatment options remain limited. Although tendinopathy is recognized as a multifactorial disorder, known risk factors and predisposing conditions have largely been studied in isolation. In this review, it is aimed to examine the various pathomechanisms identified to date and synthesize them into a unified concept. Particular emphasis is placed on key drivers believed to be critical in the onset and progression of the disease—namely mechanical stress, inflammation, and vascular changes. By exploring molecular signaling pathways and conditions involved in tendinopathy, how these mechanisms interact and reinforce one another is illustrated, forming a complex and dynamic signaling network, referred to as the tendinopathic loop. In the future, this network is expected to become even more intricate with the inclusion of emerging concepts such as intratendinous pressure and the potential influence of metabolic factors.}, archive = {J_ADVS}, author = {Renate Gehwolf and Herbert Tempfer and Nevra Pelin Cesur and Andrea Wagner and Andreas Traweger and Christine Lehner}, doi = {10.1002/advs.202506440}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06440}, shortjournal = {Adv. Sci.}, title = {Tendinopathy: The interplay between mechanical stress, inflammation, and vascularity}, volume = {12}, year = {2025}, }
• (2025). Acoustic metasurface for space-time reflection manipulation. ADVS, 12(36), e06308. (www)

  @article{ , abstract = {Recently, space-time modulation has revolutionized the wave engineering technologies, providing unprecedented opportunities beyond traditional static systems. This advancement is crucial across diverse fields, ranging from non-reciprocal transmission to wireless communication. However, the current approaches to sound modulation require bulky artificial structures and are limited in achieving space-time-variable sound-matter interactions. Here, a prototype of space-time acoustic metasurface (STAM) is proposed and implemented, consisting of a reflective piezoelectric array controlled by a field-programmable gate array. Leveraging the spatiotemporally programmable phases of the STAM, this is experimentally achieved Doppler-like chirp modulation and space-time modulation with deterministic frequency and momentum shifts of waterborne acoustic waves. Furthermore, based on this flexible and efficient modulation strategy, a stochastic space-time modulation method is introduced, showcasing its applications in single-channel direction-of-arrival estimation. The proposed STAM extends the frontier of wave control and thereby lays the foundation for versatile space-time applications involving sound.}, archive = {J_ADVS}, author = {Yunhan Yang and Han Jia and Jiuyang Lu and Yuzhen Yang and Tuo Liu and Jun Yang and Zhengyou Liu}, doi = {10.1002/advs.202506308}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06308}, shortjournal = {Adv. Sci.}, title = {Acoustic metasurface for space-time reflection manipulation}, volume = {12}, year = {2025}, }
• (2025). Synthesis of poly(1,4-anthraquinone) using catalytic amounts of nickel. ADVS, 12(36), e06251. (www)

  @article{ , abstract = {Multivalent metal batteries are attractive options to diversify energy storage options offering higher sustainability, but the high charge density of multivalent ions poses challenges to electrode materials. Organic electrode materials are currently the best-performing candidates, and among them, poly(1,4-anthraquinone) ( P14AQ ) shows excellent electrochemical properties. This holds in particular for magnesium-ion batteries, where the polymer displays reversible insertion of Mg 2+ ions with high cycling stability. The conventional synthesis of P14AQ , however, employs stoichiometric amounts of bis(cycloocta-1,5-diene)nickel(0) (Ni(COD) 2 ), which is an air- and light-sensitive and expensive chemical, and therefore lacks sustainability. Herein a synthetic route to P14AQ is presented that uses only catalytic amounts of dibromobis(triphenylphosphine)nickel(II) (NiBr 2 (PPh 3 ) 2 ). This route – in addition to being more cost-efficient and less toxic – results in higher yields and polymer molecular weights. A life-cycle assessment (LCA) comparing the new and conventional polymerization methods shows that regarding the environmental impact categories climate change, human toxicity, and cumulative energy demand, the new method brings significant improvement.}, archive = {J_ADVS}, author = {Florin Adler and Sebastián Pinto-Bautista and Christoph Lorenz and Lars Hinrichs and Marcel Weil and Birgit Esser}, doi = {10.1002/advs.202506251}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06251}, shortjournal = {Adv. Sci.}, title = {Synthesis of poly(1,4-anthraquinone) using catalytic amounts of nickel}, volume = {12}, year = {2025}, }
• (2025). Biohybrid computing with proteinoids and algae. ADVS, 12(36), e06155. (www)

  @article{ , abstract = {Proteinoids, or thermal proteinoids, are produced by heating amino-acids. When placed in water, proteinoids swell into microspheres which produce neuron-like spikes of electrical potential. This study combines proteinoid microspheres with Emiliania huxleyi algae to create advanced bioelectronic signal processing systems with neuromorphic characteristics. The morphologies of L-Glu:L-Phe proteinoid microspheres and their interactions with algae are studied using scanning electron microscopy, revealing complex structures with budding forms and traits of self-assembly. Electrical measurements demonstrate that both pure algae and algae-proteinoid mixtures generate spontaneous oscillations with unique amplitude and frequency patterns across different recording channels. The algae-proteinoid mixture exhibits a broad range of oscillatory dynamics with amplitudes varying from 25.49 to 191.42 mV and periods ranging from 251.92 to 5471.01 s. These oscillatory behaviors are utilized to perform Boolean logic operations, through post-processing of biological signals rather than autonomous computing, with pure algae systems showing superior performance for direct gates (AND, OR) while the mixture excels at inverse gates (NAND, NOR). Temperature and pH emerge as critical factors controlling oscillatory dynamics. The findings indicate that algae-proteinoid electrochemical systems represent a step toward biohybrid computing and offer a sustainable and biocompatible alternative for unconventional computing, providing enhanced signal stability, environmental resilience, and more effective information processing compared to traditional electronic systems while acknowledging current limitations in autonomous learning capabilities.}, archive = {J_ADVS}, author = {Panagiotis Mougkogiannis and Andrew Adamatzky}, doi = {10.1002/advs.202506155}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06155}, shortjournal = {Adv. Sci.}, title = {Biohybrid computing with proteinoids and algae}, volume = {12}, year = {2025}, }
• (2025). FBXO2 alleviates intervertebral disc degeneration via dual mechanisms: Activating PINK1-parkin mitophagy and ubiquitinating LCN2 to suppress ferroptosis. ADVS, 12(36), e06150. (www)

  @article{ , abstract = {Intervertebral disc degeneration (IVDD), a leading cause of chronic low back pain, arises from nucleus pulposus (NP) cell dysfunction due to oxidative stress-induced mitophagy impairment and ferroptosis, though regulatory mechanisms remain unclear. F-box only protein 2 (FBXO2), a Kruppel-like factor 10 (KLF10)-regulated F-box protein, is downregulated in degenerated human NP tissues and correlates with disease severity. Overexpression of FBXO2 restores extracellular matrix (ECM) homeostasis by promoting matrix component synthesis and inhibiting catabolic enzymes, while its knockdown exacerbates ECM degradation. Under oxidative stress, FBXO2 activates PTEN-induced putative kinase 1 (PINK1)/Parkin-dependent mitophagy, restoring mitochondrial membrane potential and reducing reactive oxygen species (ROS) accumulation. Proteomics reveals that FBXO2 suppresses ferroptosis by attenuating lipid peroxidation, glutathione depletion, and iron overload. Mechanistically, FBXO2 binds lipocalin-2 (LCN2) via its FBA domain, promoting K27-linked polyubiquitination to drive proteasomal degradation of this ferroptosis inducer. FBXO2 co-expression reverses LCN2-induced mitochondrial dysfunction and ferroptosis markers. In vivo, adeno-associated virus 9 (AAV9)-mediated overexpression of FBXO2 ameliorates IVDD in rats, whereas FBXO2 knockout (KO) mice exhibit exacerbated IVDD. LCN2 silencing in FBXO2-deficient mice partially restores disc integrity and matrix component expression. These findings identify FBXO2 as a dual regulator coordinating mitophagy activation and ferroptosis suppression, offering therapeutic potential for IVDD progression.}, archive = {J_ADVS}, author = {Tongde Wu and Yanjin Wang and Beiduo Shen and Kai Guo and Ziqi Zhu and Yongzhou Liang and Jianhua Zeng and Desheng Wu}, doi = {10.1002/advs.202506150}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06150}, shortjournal = {Adv. Sci.}, title = {FBXO2 alleviates intervertebral disc degeneration via dual mechanisms: Activating PINK1-parkin mitophagy and ubiquitinating LCN2 to suppress ferroptosis}, volume = {12}, year = {2025}, }
• (2025). Spin-orchestrated lithium diffusion in reforged ferromagnetic Fe@C anodes. ADVS, 12(36), e06133. (www)

  @article{ , abstract = {This reports a dual-functional approach in which Fe catalysts, initially employed for methane pyrolysis to generate COx-free hydrogen, are directly repurposed as anode materials following in situ carbon deposition. During methane splitting, catalytic decomposition of CH₄ at 900 °C forms onion-like graphitic carbon shells (≈280 layers) around Fe cores (≈50 nm), producing a structurally stable and electrically conductive Fe@C900 composite without post-treatment. This carbon-enriched catalyst demonstrates exceptional electrochemical behavior when transitioned into a battery context. Without any conductive additives, Fe@C900 delivers a reversible capacity of 380 mAh g⁻¹ with 98% retention over 1000 cycles at 1 C. Under a 5000 G magnetic field, spin alignment within the Fe cores triggers directional lithium-ion migration, enhancing rate performance by 150%. Multimodal characterization reveals accelerated lithium kinetics, stable SEI evolution, and deep lithiation behavior. DFT calculations further confirm strong lithium adsorption (−24.14 eV) and low insertion barriers (−22.85 eV), validating the spin-guided diffusion mechanism. This work introduces a new class of hydrogen-derived ferromagnetic anodes, where the byproduct of a clean hydrogen process is re-engineered into a high-rate, conductor-free lithium storage platform. By coupling hydrogen generation with energy storage through shared material intermediates, this strategy offers a scalable path to carbon-efficient, magnetically enhanced battery systems.}, archive = {J_ADVS}, author = {Myeong Seok Goh and Hyunsub Shin and Jaehun Lee and No-Kuk Park and Joonwoo Kim and Sang Woo Joo and Ki Hyeon Kim and Misook Kang}, doi = {10.1002/advs.202506133}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06133}, shortjournal = {Adv. Sci.}, title = {Spin-orchestrated lithium diffusion in reforged ferromagnetic Fe@C anodes}, volume = {12}, year = {2025}, }
• (2025). Quorum sensing inhibits type III-A CRISPR-cas system activity through repressing positive regulators SarA and ArcR in staphylococcus aureus. ADVS, 12(36), e06049. (www)

  @article{ , abstract = {CRISPR-Cas is an adaptive immune system that protects prokaryotes from the invasion of foreign genetic elements. The components and immunity mechanisms of CRISPR-Cas have been extensively studied, but the regulation of this system in Staphylococci remains unclear. Here, it is shown that the cell-cell communication, known as quorum sensing (QS), inhibits the expression and activity of the type III-A CRISPR-Cas system in S. aureus . The QS regulator, AgrA, directly binds to the promoters of two transcriptional regulators encoding the genes sarA and arcR to inhibit their expression. However, both SarA and ArcR act as positive regulators that promote the transcription of cas genes by directly binding to a novel promoter P cas . Furthermore, the P cas of 300 bp located in cas1 displays as a critical regulatory node to initiate the transcription of cas10 and csm3 . Our data reveal a new regulatory mechanism for QS-mediated repression of the Type III-A CRISPR-Cas system, which may allow S. aureus to acquire foreign genetic elements encoding antibiotic resistance or virulence factors specifically at high cell density.}, archive = {J_ADVS}, author = {Yang Li and Yuanyue Tang and Xiaofei Li and Nina Molin Høyland-Kroghsbo and Hanne Ingmer and Xinan Jiao and Qiuchun Li}, doi = {10.1002/advs.202506049}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06049}, shortjournal = {Adv. Sci.}, title = {Quorum sensing inhibits type III-A CRISPR-cas system activity through repressing positive regulators SarA and ArcR in staphylococcus aureus}, volume = {12}, year = {2025}, }
• (2025). Structurally constrained cyclic (Diacyloxyiodo)Arenes as an enabling platform for hypervalent Iodine(III) chemistry. ADVS, 12(36), e06041. (www)

  @article{ , abstract = {Hypervalent iodine(III) chemistry has unlocked remarkable potential in synthetic and catalytic applications over the past decades, yet its development has been constrained by biased thermodynamics between iodine(I) and iodine(III) species, relying on unstable or environmentally unfriendly oxidants and complex electrocatalytic platforms. Here, structurally constrained cyclic (diacyloxyiodo)arenes are presented as a transformative platform to resolve the reactivity/selectivity-generality paradox, enabling one-pot synthesis of diverse hypervalent iodine(III) reagents. The synthetic utility and sustainability of the in situ controlled-release approach are demonstrated through catalytic reactions, asymmetric variations, and biocompatibility studies, including peptide modifications. Central to this success is the discovery of cyclic (diacyloxyiodo)arenes—a previously unexplored chemical entity. DFT calculations reveal that spatial dianion control via intramolecular secondary bonding enhances reactivity and selectivity while delivering superior outcomes.}, archive = {J_ADVS}, author = {Shengyu Zhong and Shaoyan Gan and Xin Zhang and Lijuan Song and Lei Shi}, doi = {10.1002/advs.202506041}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e06041}, shortjournal = {Adv. Sci.}, title = {Structurally constrained cyclic (Diacyloxyiodo)Arenes as an enabling platform for hypervalent Iodine(III) chemistry}, volume = {12}, year = {2025}, }
• (2025). EGFR: New insights on its activation and mutation in tumor and tumor immunotherapy. ADVS, 12(36), e05785. (www)

  @article{ , abstract = {The success of immune checkpoint blockades (ICBs) has accelerated the clinical implementation of multiple single agents and combination immunotherapies, but the response rates vary. Reconsideration of immune-oncology therapeutic failures via perspective from tumor-intrinsic (such as oncogenic driver genes) and tumor-extrinsic (the complexity of immune cell–cancer cell interactions) may help to better design more effective anticancer drugs and treatment strategies. Herein, in this review, introducing the frequently mutated gene EGFR in tumors and its abnormal activation are mainly focused on, highlighting that epidermal growth factor receptor (EGFR) wild-type and mutants respond differently to ICBs via tumor-intrinsic and tumor-extrinsic manners. Through briefly reviewing how EGFR is activated and the current EGFR targeting strategy, the present clinical trials of combination with EGFR inhibitors and ICBs are summarized, and the mechanism by which EGFR affects immunotherapy and measures to improve the efficacy of immunotherapy are discussed.}, archive = {J_ADVS}, author = {Yuanzhuo Gu and Hongchao He and Shilei Qiao and Yifan Shao and Lurong Wang and Zhengkui Zhang and Long Zhang and Fangfang Zhou}, doi = {10.1002/advs.202505785}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e05785}, shortjournal = {Adv. Sci.}, title = {EGFR: New insights on its activation and mutation in tumor and tumor immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Memristive in-memory object detection with 128 mb C-doped Ge2Sb2Te5 PCM chip. ADVS, 12(36), e05678. (www)

  @article{ , abstract = {Object detection, as a fundamental task in computer vision, mainly performs the classification and localization of objects in images or videos. However, traditional edge computing platforms fall short of meeting the demands for state-of-the-art object detection model size and computing power. Here, a 128 Mb phase change memory chip is fabricated with a high memory yield of 99.99999% in a 40 nm node and utilized for efficient in-memory vector-matrix multiplication and in-memory max computation. In particular, in order to mitigate the significant programming energy overheads for large-scale memristor arrays and the reliance on high-precision analog-to-digital-converter (ADC) in compute-in-memory operations, a novel mixed-precision weight mapping strategy is adopted. Compared with traditional schemes, the ADC modules achieve up to a 22.3× reduction in energy consumption while maintaining equivalent network performance. Ultimately, this memristive in-memory object detection system demonstrates 4,180× higher energy efficiency and 228× greater computational throughput compared to GPU implementations.}, archive = {J_ADVS}, author = {Chenchen Xie and Yuqi Li and Longhao Yan and Sannian Song and Houpeng Chen and Ruijuan Qi and Xi Li and Yihang Zhu and Lianfeng Yu and Bonan Yan and Yaoyu Tao and Gaoming Feng and Yuchao Yang and Zhitang Song}, doi = {10.1002/advs.202505678}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e05678}, shortjournal = {Adv. Sci.}, title = {Memristive in-memory object detection with 128 mb C-doped Ge2Sb2Te5 PCM chip}, volume = {12}, year = {2025}, }
• (2025). Bacterial minicell-based biohybrid sub-micron swimmers for targeted cargo delivery. ADVS, 12(36), e05538. (www)

  @article{ , abstract = {Bacterial biohybrid microrobots possess significant potential for targeted cargo delivery and minimally invasive therapy. However, many challenges, such as biocompatibility, stability, and effective cargo loading, remain. Bacterial membrane vesicles, also referred to as minicells, offer a promising alternative for creating sub-micron scale biohybrid swimmers (minicell biohybrids) due to their active metabolism, non-dividing nature, robust structure, and high cargo-carrying capacity. Here, a biohybrid system is reported that utilizes motile minicells, ≈400 nm in diameter, generated by aberrant cell division of engineered Escherichia coli ( E. coli ), for the first time. Achieving over 99% purification from their parental bacterial cells, minicells are functionalized with magnetic nanoparticles (MNPs) to enable external magnetic control. Minicell biohybrids are capable of swimming at an average speed of up to 13.3 µm s −1 and being steered under a uniform magnetic field of 26 mT. Furthermore, they exhibit a significantly high drug loading capacity (2.8 µg mL −1 ) while maintaining their motility and show pH-sensitive release of anticancer drug doxorubicin hydrochloride (DOX) under acidic conditions. Additionally, drug-loaded minicell biohybrids notably reduce the viability of SK-BR-3 breast cancer cells in vitro. This study introduces minicell biohybrids and establishes their potential as magnetically guided, drug-loaded biohybrid systems for targeted therapies in future medical applications.}, archive = {J_ADVS}, author = {Saadet Fatma Baltaci and Mukrime Birgul Akolpoglu and Irina Kalita and Victor Sourjik and Metin Sitti}, doi = {10.1002/advs.202505538}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e05538}, shortjournal = {Adv. Sci.}, title = {Bacterial minicell-based biohybrid sub-micron swimmers for targeted cargo delivery}, volume = {12}, year = {2025}, }
• (2025). Stretchable and biodegradable thermally expandable composites with microfluidics for on-demand and programmable destruction of electronics. ADVS, 12(36), e05487. (www)

  @article{ , abstract = {The lifespan of the transient electronic system can be determined in advance (i.e., predefined) or controlled via on-demand and programmable approaches using a diverse range of principles. However, in most cases, dissolution or disappearance requires an aqueous solution and is only possible for the entire system, not for specific or targeted components. Here, a soft, stretchable, thermally expandable system is introduced for precise, localized, on-demand deactivation or destruction of electronic systems. The incorporation of thermal expansion particles into a polymer matrix produces soft, resilient composites that generate substantial thermo-mechanical forces at a predefined temperature, enabling the direct collapse of electronic devices. Integration with multichannel microfluidics and wireless systems creates a vanishing, self-destructive optoelectronic system and bio-safe drug delivery vehicle for frequency-based selective release, demonstrating the broad potential of this approach in the fields of defense/security and biomedical devices as well as other envisioned areas.}, archive = {J_ADVS}, author = {Chan-Hwi Eom and Won Bae Han and Sungkeun Han and So Jeong Choi and Ikkyo Choi and Jeonguk Kim and Hyewon Cho and Li-Hyun Kim and Venkata Ramesh Naganaboina and Gwan-Jin Ko and Tae-Min Jang and Suk-Won Hwang}, doi = {10.1002/advs.202505487}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e05487}, shortjournal = {Adv. Sci.}, title = {Stretchable and biodegradable thermally expandable composites with microfluidics for on-demand and programmable destruction of electronics}, volume = {12}, year = {2025}, }
• (2025). Ultra-low hysteresis under large deformation enabled by fast chains relaxation in highly competitive dynamic hydrogen bond networks. ADVS, 12(36), e05417. (www)

  @article{ , abstract = {High-quality capture of diverse motion signals in flexible sensors requires soft sensing materials to perform signal conversion and transmission stably and without delay over extended periods. However, low hysteresis achieved through purely elastic mechanisms easily exhibits poor crack propagation resistance. By leveraging the significant gap between the strain rate during large-strain service conditions and the crack propagation rate in the fracture process, this study presents a facile strategy for constructing a highly competitive dynamic hydrogen bonding system to produce near-zero-hysteresis and highly crack-resistant D-gels. Through tuning the relaxation dynamics of strong hydrogen bonding interactions with polymer segments by insert deep eutectic solvent (DES) components, the highly dynamic hydrogen bonds are rendered mechanically “invisible” during service condition—an essential factor in achieving a low-hysteresis attribute (low hysteresis: <3%). Meanwhile, the relaxation time of those dynamic bonds is comparable to the inverse of crack propagation rate, effectively alleviating stress concentration at the crack tips, thereby enhancing the ultimate fracture strain (1500%) and crack propagation strain (550%) of the gels. This approach provides a general strategy for synthesizing gels that overcome the traditional trade-off between high crack propagation resistance and high elasticity.}, archive = {J_ADVS}, author = {Shuaijun Guo and Shilei Zhu and Yang Qiao and Shanhao Feng and Xin Yang and Beibei Kang and Chaojun Yue and Yanjing Zhang and Zhuangzhuang Li and Ya Nan Ye and Qiang Zheng}, doi = {10.1002/advs.202505417}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e05417}, shortjournal = {Adv. Sci.}, title = {Ultra-low hysteresis under large deformation enabled by fast chains relaxation in highly competitive dynamic hydrogen bond networks}, volume = {12}, year = {2025}, }
• (2025). Subgenome partitioning and polyploid genome evolution in the loach family botiidae (Order cypriniformes). ADVS, 12(36), e05411. (www)

  @article{ , abstract = {Vertebrates have undergone two rounds of whole-genome duplication (WGD), termed 1R and 2R, with a third, teleost-specific duplication (TSGD or 3R) occurring in ray-finned fishes. In the order Cypriniformes, additional lineage-specific WGDs have further contributed to species diversification. While polyploidy is well characterized in species like common carp and goldfish, other polyploid taxa—particularly loaches—remain understudied. Here, high-quality, chromosome-level genome assemblies are presented for two loach species: Sinibotia superciliaris (Golden Chinese Loach) and Parabotia fasciatus (Yichang Sand Loach). By integrating these genomes into a comparative framework with 20 other cypriniform species, key phylogenetic relationships are reconstructed, and introduce a novel subgenome partitioning method (M3). Unlike previous approaches, M3 uses differential sequence divergence to accurately and rapidly assign subgenomes, completing partitioning within minutes and outperforming existing tools. Applying M3, a markedly reduced subgenome is uncovered in the Golden Chinese Loach, with lineage-specific molecular changes in several candidate genes, suggesting potential adaptive significance. This study offers a comprehensive view of polyploidy and subgenome evolution in loaches, highlighting the genomic complexity shaped by repeated WGDs in Cypriniformes and providing valuable resources for future research on vertebrate genome evolution and adaptation.}, archive = {J_ADVS}, author = {Yunyun Lv and Jia Li and Yanping Li and Yu Huang and Qiang Lai and Zhengyong Wen and Jun Wang and Yang He and Jinrong Shi and Zejin Huang and Ying Jiang and Yves Van de Peer and Qiong Shi and Biwen Xie and Yongming Wang}, doi = {10.1002/advs.202505411}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e05411}, shortjournal = {Adv. Sci.}, title = {Subgenome partitioning and polyploid genome evolution in the loach family botiidae (Order cypriniformes)}, volume = {12}, year = {2025}, }
• (2025). Stiffness-tunable neurotentacles for minimally invasive implantation and long-term neural activity recordings. ADVS, 12(36), e05100. (www)

  @article{ , abstract = {Flexible microelectrodes are ideal for chronic neural recordings; however, their low bending strength poses challenges during probe insertion. Here, a stiffness-tunable polyimide probe, termed Neurotentacle, is proposed for deep brain implantation. Its tunability is enabled by embedded microchannels with controllable liquid pressure. During insertion, the Neurotentacle becomes stiff under elevated internal pressure, allowing penetration of brain tissue without additional materials or tools. Once inserted, it regains flexibility by reducing the internal pressure. The novel ultra-thin microchannel fabrication technique enables the Neurotentacle to maintain dimensions similar to conventional flexible probes. This minimizes tissue damage during insertion while ensuring long-term biocompatibility and stability, confirmed by histological evaluations in both acute and chronic animal models. In long-term recordings, Neurotentacles outperform traditional shuttle-assisted implantation methods. The technique is straightforward, controllable, and does not require complex devices, making it ideal for minimally invasive implantation and long-term neural recordings.}, archive = {J_ADVS}, author = {Yang Wang and Xing Xu and Xiaowei Yang and Rongyu Tang and Ying Chen and Shan Zang and Yijun Wang and Jing Liang and Weihua Pei}, doi = {10.1002/advs.202505100}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e05100}, shortjournal = {Adv. Sci.}, title = {Stiffness-tunable neurotentacles for minimally invasive implantation and long-term neural activity recordings}, volume = {12}, year = {2025}, }
• (2025). Multi-physically programmable tubular origami metamaterials: Exploitable nexus of geometry, folding mechanics and stimuli-responsive physics. ADVS, 12(36), e05089. (www)

  @article{ , abstract = {Metamaterials and metastructures developed based on tubular origami-inspired structural forms can leverage the convolution of geometry, crease mechanics and stimuli-responsive physics to provide unique mechanical and functional properties, including geometric efficiency and compactness, deployability and reconfigurability, structural integration ability in complex shapes, stiffness and strength modulation, constitutive programming and deformation mode coupling, high specific energy absorption, multi-stability, and programmable dynamic behavior, leading to diverse applications in the field of mechanical, robotics, space, electronic devices and communication, biomedical, and architecture. With stupendous advancement over the last decade in computational and manufacturing capabilities to realize complex crease architectures along with on-demand programmability through coupling folding-driven mechanics with stimuli-responsive physics of electrical or magnetic fields, temperature, light, controlled chemical reactions, and pneumatic actuation, the field of origami-inspired mechanical metamaterials has been attracting wide attention due to immense potential of achieving unprecedented multi-physical and multi-functional attributes that are typically not attainable in naturally-occurring materials or traditional structures. This article endeavours to review the developments reported in relevant literature concerning mechanical and multi-physical property modulation of tubular origami metamaterials, highlighting the broad-spectrum potential in innovative applications across the length scales along with critically analysing the emerging trends, challenges and potential future research landscape.}, archive = {J_ADVS}, author = {A. Sharma and S. Naskar and T. Mukhopadhyay}, doi = {10.1002/advs.202505089}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e05089}, shortjournal = {Adv. Sci.}, title = {Multi-physically programmable tubular origami metamaterials: Exploitable nexus of geometry, folding mechanics and stimuli-responsive physics}, volume = {12}, year = {2025}, }
• (2025). Integrating molecular dynamics and machine learning for solvation-guided electrolyte optimization in lithium metal batteries. ADVS, 12(36), e04997. (www)

  @article{ , abstract = {Optimizing liquid electrolytes is essential for achieving long-term cycling stability and high safety in lithium metal batteries. However, severe side reactions and lithium dendrite formation during repeated cycling lead to low Coulombic efficiency (CE) and limited lifespan. Herein, a rapid and cost-effective strategy that integrates high-throughput molecular dynamics simulations with machine learning predictions is proposed, further validated through experimental evaluation. A mixed electrolyte composed of LiFSI (LiN(SO 2 F) 2 ) as the main salt, DEE (1,2-diethoxyethane) as the solvent, and LiNFS (LiC 4 F 9 SO 3 ) as an additive achieves a significantly improved CE of 98.32%. Key molecular descriptors are identified for each performance label, and the most accurate model is selected through rigorous benchmarking. The optimal region reveals a preference for medium-to-high salt concentrations; low C, O, and N content; and high F content in salts, along with high C and low O content in solvents. This framework enables reusable and resource-efficient modeling for targeted electrolyte design and accelerated optimization.}, archive = {J_ADVS}, author = {Xiwang Chang and Yang Yang and Weiheng Xu and Zhe Wang and Wenhan Li and Hongda Gao and Dubin Huang and Aijun Li and Yaofeng Zhu}, doi = {10.1002/advs.202504997}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04997}, shortjournal = {Adv. Sci.}, title = {Integrating molecular dynamics and machine learning for solvation-guided electrolyte optimization in lithium metal batteries}, volume = {12}, year = {2025}, }
• (2025). Nanoparticle drug delivery systems for atherosclerosis: Precision targeting, inflammatory modulation, and plaque stabilization. ADVS, 12(36), e04990. (www)

  @article{ , abstract = {Atherosclerosis remains a leading contributor to cardiovascular morbidity and mortality, presenting considerable therapeutic challenges due to its multifaceted and complex pathogenesis. This review systematically explores the pathophysiological mechanisms underlying atherosclerosis and examines recent advances in nanoparticle drug delivery systems (NDDSs) tailored for atherosclerosis treatment. NDDS has many advantages in this setting. It can precisely modulate the cellular activities critical to atherosclerotic progression, and by using targeted delivery strategies directed at lesion-specific biomarkers and incorporating stimulus-responsive drug release mechanisms responsive to the plaque microenvironments, it can significantly increase therapeutic efficacy while minimizing adverse systemic and off-target effects. Thus, NDDS effectively addresses the limitations of traditional pharmacological treatments, enabling personalized interventions that can attenuate disease progression, stabilize vulnerable plaques, and facilitate plaque regression. This review highlights the transformative possibilities of NDDSs, emphasizing their potential to redefine current therapeutic paradigms and improve patient outcomes in atherosclerosis.}, archive = {J_ADVS}, author = {Yunqi Zhang and Feifei Li and Libo Liu and Ziyu An and Hanzhong Luo and Huan Zhang and Rui Ma and Ruoxi Zhang and Qiong Dai and Mingduo Zhang and Jinfan Tian and Chaoyong Liu and Xiantao Song and Yunfeng Lu}, doi = {10.1002/advs.202504990}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04990}, shortjournal = {Adv. Sci.}, title = {Nanoparticle drug delivery systems for atherosclerosis: Precision targeting, inflammatory modulation, and plaque stabilization}, volume = {12}, year = {2025}, }
• (2025). Dual-modular hydrogel microparticles with precision-modulation of inflammatory microenvironment dictate full-thickness cartilage regeneration for osteoarthritis repair. ADVS, 12(36), e04965. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a typical degenerative disease characterized primarily by the degeneration of cartilage. However, current treatments for cartilage degeneration often lead to the formation of hypertrophic cartilage and fibrocartilage, making it challenging to achieve full-thickness cartilage. Here, dual-modular hydrogel microparticles (dmHMPs) are developed, which enable precise spatio-temporal modulation and dynamic equilibrium between immune responses and cartilage regeneration. dmHMPs can modulate the inflammatory microenvironment of the joint by promoting the polarization of synovial macrophages toward an anti-inflammatory phenotype. Consequently, as inflammation is mitigated, synovium-derived mesenchymal stem cells recruited by dmHMPs can efficiently undergo chondrogenic differentiation to repair damaged cartilage in situ. In vivo experiments demonstrate that dmHMPs significantly suppress the expression of Indian hedgehog (Ihh) and collagen type X, thereby reducing the formation of hypertrophic cartilage and preserving the structural integrity and biological functions of articular cartilage. This therapeutic modulates the dynamic balance between inflammation and repair, providing a promising approach for full-thickness cartilage regeneration.}, archive = {J_ADVS}, author = {Xinye Chen and Yuanman Yu and Zirui He and Lina Pan and Jing Wang and Changsheng Liu}, doi = {10.1002/advs.202504965}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04965}, shortjournal = {Adv. Sci.}, title = {Dual-modular hydrogel microparticles with precision-modulation of inflammatory microenvironment dictate full-thickness cartilage regeneration for osteoarthritis repair}, volume = {12}, year = {2025}, }
• (2025). Covalent organic frameworks-delivered reuterin drives trained immunity in tumor-associated macrophages to enhance melanoma immunotherapy via glycerophospholipid metabolism. ADVS, 12(36), e04784. (www)

  @article{ , abstract = {The gut microbiota is increasingly recognized as a promising therapeutic target in cancer treatment. However, the specific mechanisms by which gut bacteria and their metabolites exert therapeutic effects in melanoma remain poorly understood. In this study, it is unexpectedly demonstrated that prophylactic supplementation with Limosilactobacillus reuteri exhibits significant tumor-suppressive properties, primarily mediated by its secreted metabolite, reuterin. This metabolite induces trained immunity through macrophage metabolic reprogramming, thereby enhancing antitumor immune responses. Mechanistically, this process involves stabilizing HIF-1α via the AHR-ROS signaling pathway, enhancing glycerophospholipid metabolism, and elevating arachidonic acid levels, thereby amplifying the trained immunity response. Similar to reuterin, arachidonic acid also induces trained immunity and facilitates macrophage-mediated tumor cell killing. To enhance its therapeutic efficacy, reuterin is encapsulated in covalent organic frameworks (COFs). COF-Reuterin demonstrates superior effects in tumor-associated macrophages (TAMs), remodulating intratumor bacteria and directly facilitating tumor cell killing. Notably, COF-Reuterin demonstrates superior therapeutic efficacy compared to cisplatin. Furthermore, COF-Reuterin reprogrammed TAMs from an M2 to an M1 phenotype, increasing CD8 + T cell infiltration and decreasing myeloid-derived suppressor cells (MDSCs), reshaping the immunosuppressive tumor microenvironment. These findings highlight the potential of probiotics and their metabolites in the metabolic reprogramming of TAMs, offering a promising cancer therapeutic approach.}, archive = {J_ADVS}, author = {Jian-Gang Zhang and Xiao-Mei Zhang and Xi Wu and Cheng-Kai Zhou and Zhen-Zhen Liu and Xue-Yue Luo and Liang Zhang and Wei Chen and Yong-Jun Yang}, doi = {10.1002/advs.202504784}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04784}, shortjournal = {Adv. Sci.}, title = {Covalent organic frameworks-delivered reuterin drives trained immunity in tumor-associated macrophages to enhance melanoma immunotherapy via glycerophospholipid metabolism}, volume = {12}, year = {2025}, }
• (2025). Adaptive machine learning for electronic nose-based forensic VOC classification. ADVS, 12(36), e04657. (www)

  @article{ , abstract = {Odor detection as forensic evidence is an emerging and transformative approach for identifying individuals in cases where conventional techniques— such as DNA profiling, fingerprints, or gas chromatography-mass spectroscopy— are insufficient. Key challenges include distinguishing between living and deceased individuals, differentiating human from animal remains, and estimating postmortem intervals. While specially trained dogs remain the gold standard in some contexts, there is growing demand for faster, scalable, and cost-effective alternatives. Here, a bio-inspired electronic nose comprising 32 metal-oxide sensors, integrated with machine learning, is presented as a non-invasive, real-time, and reliable tool for volatile organic compound profiling. The system accurately classifies postmortem versus antemortem human biosamples (98.1%), discriminates human from animal tissue (97.2%), and estimates postmortem intervals with high temporal resolution. This study introduces a robust AI-driven olfactory platform for forensic scent detection, highlighting its potential to complement or replace traditional methods. By coupling volatilome analysis with sensor miniaturization and algorithmic refinement, this approach lays the groundwork for next-generation forensic diagnostics and odor-based biomarker discovery.}, archive = {J_ADVS}, author = {Ivan Shtepliuk and Kerstin Montelius and Jens Eriksson and Donatella Puglisi}, doi = {10.1002/advs.202504657}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04657}, shortjournal = {Adv. Sci.}, title = {Adaptive machine learning for electronic nose-based forensic VOC classification}, volume = {12}, year = {2025}, }
• (2025). Interface controlled electric field swing adsorption. ADVS, 12(36), e04617. (www)

  @article{ , abstract = {Influencing the adsorptive processes of gases by external stimuli is an ongoing research task of academic and technological relevance. Technologically external stimuli like pressure, vacuum, temperature, magnetic field, or electrical phenomena are the most common ones with which adsorptive and desorptive processes can be influenced. In the case of pure electric field swing adsorption (EFSA) of solid/gas mixtures, however, experimental knowledge concerning carbon materials is lacking so far. A new approach to the electrical field effect on gas adsorption and desorption is presented. Ar, N 2 and CO 2 interact with an all-solid composite material composed of activated porous carbon and silica characterized by a high amount of charged interfaces under isothermal conditions and ambient temperature. The intimate contact of both components in the composite allows for the formation of multiple resistor-conductor interfaces enabling the reversible physisorption of these gases using electric fields in the lower V and mA range. The adsorptive/desorptive swing effect depends on the polarizabilities of the gases in particular their dipoles and to an even larger extent on the field induced quadrupole moments of the probe gases Ar, N 2 and CO 2 .}, archive = {J_ADVS}, author = {Silvio Heinschke and Jörg J. Schneider}, doi = {10.1002/advs.202504617}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04617}, shortjournal = {Adv. Sci.}, title = {Interface controlled electric field swing adsorption}, volume = {12}, year = {2025}, }
• (2025). ChromInSight: Revealing DNA double-strand breaks through chromatin structural insights with an interpretable graph neural network framework. ADVS, 12(36), e04571. (www)

  @article{ , abstract = {DNA double-strand breaks (DSBs) represent one of the most severe forms of genomic damage. Although substantial progress has been made in elucidating general patterns associated with DSBs, the influence of 3D chromatin structure on DSB formation remains underexplored, particularly concerning its spatial configuration. Here, the ChromInSight framework is introduced. Using standardized datasets,Hi-DSB is developed and deployed in ChromInSight, a genome-wide DSB prediction model based on graph contrastive learning (GCL), and applied advanced interpretability techniques to identify DSB-associated genomic patterns. The findings reveal that the spatial cluster-scene between hub nodes and DSB sites is predominantly shaped by the 3D conformation of chromatin, rather than by linear genomic distance. This phenomenon is validated at both the Loop and topologically associating domain (TAD) levels and proposed a “spatial isolation – damage containment” hypothesis, which illustrates the genome strategy for managing damage. These findings support the role of 3D genome architecture in genomic instability. Consequently, the framework provides a powerful tool for investigating the intricate relationship between chromatin structure and genomic stability.}, archive = {J_ADVS}, author = {Kang Xu and Zongyuan Yu and Canzhuang Sun and Conglin Gou and Jiangyue Zhu and Jun Wang and Xiaochen Bo and Guoxian Yu and Hao Li and Hebing Chen}, doi = {10.1002/advs.202504571}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04571}, shortjournal = {Adv. Sci.}, title = {ChromInSight: Revealing DNA double-strand breaks through chromatin structural insights with an interpretable graph neural network framework}, volume = {12}, year = {2025}, }
• (2025). A high-performance garnet-based all-solid-state battery fabricated through room-temperature ultrasonic welding. ADVS, 12(36), e04388. (www)

  @article{ , abstract = {Garnet-type Li 6.5 La 3 Zr 1.5 Ta 0.5 O 12 (LLZO) has emerged as a highly promising solid electrolyte for next-generation Li metal batteries due to its high Li + conductivity and stability against metallic lithium. However, its practical application is hindered by poor interfacial contact between Li and LLZO, as well as the persistent issue of lithium dendrite formation during cycling. In this study, a novel and efficient strategy is proposed to address these challenges by employing a room-temperature ultrasonic treatment combined with a LiMg alloy anode. The fabricated symmetrical UW-LiMg/LLZO/UW-LiMg cell exhibits a low interfacial resistance and achieves an unprecedented critical current density of 4.45 mA cm −2 . Furthermore, these cells demonstrate excellent cycling stability, maintaining stable lithium plating/stripping for over 1000 h at a high current density of 1 mA cm − 2 with a low overpotential of ≈30 mV. The superior performance is attributed to the enhanced anode ductility achieved through Mg alloying and the formation of an ultra-stable interface layer. The all-solid-state UW-LiMg/LLZO/LiFePO 4 battery, incorporating an ultrasonically treated alloy anode and a fluorinated cathode interface, delivers a specific capacity of 153 mAh g −1 at 0.5 C and retains an impressive capacity retention of 90% after 200 cycles at room temperature.}, archive = {J_ADVS}, author = {Tianlu Pang and Shufen Wu and Han Wu and Xiaobao Li and Yande Li and LiTao Yu and Hui Zhang and Yong Han and Zhi Guo and Nian Zhang}, doi = {10.1002/advs.202504388}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04388}, shortjournal = {Adv. Sci.}, title = {A high-performance garnet-based all-solid-state battery fabricated through room-temperature ultrasonic welding}, volume = {12}, year = {2025}, }
• (2025). Human iPSCs derived MSCs-secreted exosomes modulate senescent nucleus pulposus cells induced macrophage polarization via metabolic reprogramming to mitigate intervertebral disc degeneration. ADVS, 12(36), e04347. (www)

  @article{ , abstract = {Intervertebral disc degeneration (IDD) is a leading cause of discogenic lower back pain, yet the crosstalk between macrophage polarization and nucleus pulposus (NP) cell senescence in IDD progression remains poorly understood. Emerging therapies using human induced pluripotent stem cell (iPSCs)-derived mesenchymal stem cells (iMSCs) show promise for IDD treatment. In this study, it is first demonstrated that senescent NP cells promote macrophage polarization toward the pro-inflammatory M1 phenotype in coculture systems. Reciprocally, conditioned medium from M1 macrophages exposed to senescent NP cells accelerates senescence in healthy NP cells. Notably, it is identified that iMSCs-derived exosomes break this pathogenic cycle by reprogramming M1 macrophages toward anti-inflammatory M2 phenotypes. Mechanistically, these exosomes deliver miR-100-5p to suppress mTORC1 signaling and regulate glycolysis metabolic reprogramming in macrophages. These findings are corroborated in a rat IDD model, where iMSC-exosomes mitigate IDD progression in vivo. This work elucidates a novel iMSC-exosomes mediated mechanism regulating macrophage-NP cell interactions, which provides a promising therapeutic strategy for IDD intervention.}, archive = {J_ADVS}, author = {Qian Xiang and Jiawen Zhan and Shuo Tian and Yongzhao Zhao and Zhenquan Wu and Jialiang Lin and Longting Chen and Longjie Wang and Shuai Jiang and Zhuoran Sun and Weishi Li}, doi = {10.1002/advs.202504347}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04347}, shortjournal = {Adv. Sci.}, title = {Human iPSCs derived MSCs-secreted exosomes modulate senescent nucleus pulposus cells induced macrophage polarization via metabolic reprogramming to mitigate intervertebral disc degeneration}, volume = {12}, year = {2025}, }
• (2025). Nanosensitizer for cancer radioimmunotherapy via anti-IL-35 blockade boosted innate immunity activation. ADVS, 12(36), e04252. (www)

  @article{ , abstract = {The cGAS-STING signaling pathway has emerged as a promising target for cancer immunotherapy. However, STING agonists have a dual-edged nature. Although they enhance antitumor T cell activity, STING agonists also elicit protumorigenic effects by promoting IL-35-producing B regulatory (Breg) cells, suppressing natural killer (NK) cell density, and fostering immune suppression. To address these challenges, this work develops a tumor microenvironment-responsive hollow mesoporous nanosystem that degrades under high glutathione conditions, thereby releasing the STING agonist MSA-2 and Mn ions. This nanosystem facilitates magnetic resonance imaging-guided chemodynamic therapy and radiosensitization, efficiently activating the cGAS-STING pathway by disrupting mitochondrial and nuclear DNA. Notably, by integrating this nanosystem with an anti-IL-35 blockade, this work successfully mitigates the Breg cell-mediated suppression of NK cells, restores innate immune responses, and enhances antitumor efficacy. This study highlights the pivotal role of anti-IL-35 in reversing immunosuppression, enhancing innate immunity, and establishing a synergistic theranostic platform for molecular imaging-guided cancer radioimmunotherapy.}, archive = {J_ADVS}, author = {Yinfei Zheng and Shuting Zheng and Yushu Liao and Zede Wu and Chenxi He and Qiuyu Li and Honglei Hu and Zheyu Shen and Yikai Xu and Chenggong Yan and Bingxia Zhao and Meirong Hou}, doi = {10.1002/advs.202504252}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04252}, shortjournal = {Adv. Sci.}, title = {Nanosensitizer for cancer radioimmunotherapy via anti-IL-35 blockade boosted innate immunity activation}, volume = {12}, year = {2025}, }
• (2025). The interplay between the gut and ketogenic diets in health and disease. ADVS, 12(36), e04249. (www)

  @article{ , abstract = {The gut plays a central role in translating dietary signals into systemic health effects, making it a key mediator of the ketogenic diet (KD), a high fat, low carbohydrate regimen. This review synthesizes current knowledge on the interaction between the KD and the gut, emphasizing gut-mediated mechanisms as an interface between dietary interventions and systemic health outcomes, spanning gastrointestinal to neurological health. Topics address gut physiology (gut digestion and absorption, epithelial nutrient sensing, gut motility), intestinal immunity (covering innate, adaptive, and antiviral responses), and extracellular to intracellular processes (i.e. mitochondrial function, stem cell fate, and intestinal circadian rhythm). Special focus is given to the gut microbiome, including both bacterial and fungal communities and how the KD modulates them in conditions such as epilepsy, obesity, traumatic brain injury, and multiple sclerosis. Innovative methods for tailoring the KD, including the use of alternative formulations, ketone esters, and microbiome-focused interventions such as prebiotics and probiotics are examined. Strategies to maximize the diet's benefits while reducing potential side effects are considered. Together, these insights herein offer a comprehensive framework for understanding the interactions between the KD and the gut, a prerequisite for optimizing the overall health benefits of metabolism-based treatments.}, archive = {J_ADVS}, author = {Chunlong Mu and Jong M. Rho and Jane Shearer}, doi = {10.1002/advs.202504249}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04249}, shortjournal = {Adv. Sci.}, title = {The interplay between the gut and ketogenic diets in health and disease}, volume = {12}, year = {2025}, }
• (2025). SF3A3 drives tumorigenesis in endometrial cancer by enhancing c-FOS expression and represents a potential therapeutic target. ADVS, 12(36), e04184. (www)

  @article{ , abstract = {Aberrant alternative splicing plays a crucial role in tumorigenesis. Here, splicing factor 3A subunit 3 (SF3A3) is   significantly upregulated in endometrial cancer (EC) tissues and associated with poor prognosis. Functionally, SF3A3 drives tumor progression by promoting cell proliferation, suppressing apoptosis, and enhancing cisplatin resistance in vitro and in vivo. Mechanistically, SF3A3 regulates alternative splicing of fos proto-oncogene, AP-1 transcription factor subunit (c-FOS), an oncogene linked to chemoresistance, resulting in a ≈2-fold increase in full-length c-FOS expression and activation of downstream anti-apoptotic pathways. Notably, phenylethyl isothiocyanate (PEITC) as a direct inhibitor of SF3A3 through database screening and biophysical validation via surface plasmon resonance and mass spectrometry is identified. PEITC reduces c-FOS expression and induces apoptosis in EC cells. Moreover, encapsulating PEITC in a hydrogel delivery system significantly enhances its therapeutic efficacy by enabling controlled release, reducing dosing frequency, and improving clinical applicability. The therapeutic potential of SF3A3 inhibition is further validated using patient-derived tumor-like cell clusters (PTCs), where PEITC and the c-FOS inhibitor T-5224 exhibit synergistic effects in suppressing EC. Collectively, our findings establish SF3A3 as a novel oncogenic regulator in EC and highlight PEITC, particularly in its hydrogel formulation, as a promising therapeutic strategy for improving clinical outcomes in EC patients.}, archive = {J_ADVS}, author = {Wei Yu and Yi Gu and Hengrui Zhang and Wunan Huang and Lei Sun and Liangjian Ma and Xiaolei Liang and Lexin Liu and Guiping Chen and Weihua Wang and Zhongkai Cao and Xue Li and Xiangjun Chen and Lidan Hu}, doi = {10.1002/advs.202504184}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e04184}, shortjournal = {Adv. Sci.}, title = {SF3A3 drives tumorigenesis in endometrial cancer by enhancing c-FOS expression and represents a potential therapeutic target}, volume = {12}, year = {2025}, }
• (2025). A human immuno-lung organoid model to study macrophage-mediated lung cell senescence upon SARS-CoV-2 infection. ADVS, 12(36), e03932. (www)

  @article{ , abstract = {While COVID-19 affects multiple organ systems, the human respiratory system is the primary viral target and main site for disease progression. In this study, spatial transcriptional assays (NanoString CosMx) are utilized to analyze both explant and autopsy samples from non-COVID and COVID-19 lungs, identifying the activation of proinflammatory macrophages in COVID-19 explants. It is further developed immuno-lung organoids comprising hPSC-derived alveolar and airway organoids co-cultured with macrophages to investigate the impact and underlying mechanisms of macrophage-mediated lung damage following SARS-CoV-2 infection. The findings demonstrate that proinflammatory macrophages induce lung cell senescence through the THBS1–(ITGA3+ITGB1) signaling axis, a mechanism further validated using spatial transcriptomics. This study not only establishes physiologically relevant immuno-lung organoid models for modeling macrophage-mediated tissue damage, but also identifies a previous unrecognized role of the THBS1-(ITGA3+ITGB1) pathway in driving lung cell senescence during infectious disease.}, archive = {J_ADVS}, author = {Yuling Han and Dongliang Leng and Tuo Zhang and Jian Ge and Yinshan Fang and Tiankun Lu and Xue Dong and Manoj S Nair and Neranjan de Silva and Zhaowei Han and Tiancheng Jiao and Yuanhao Huang and Meiqi Zhao and Anjali Saqi and Hanina Hibshoosh and Zihe Meng and Jenny Z Xiang and Chendong Pan and Yanjie Sun and David D. Ho and Todd Evans and Jie Liu and Liuliu Yang and Jianwen Que and Shuibing Chen}, doi = {10.1002/advs.202503932}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03932}, shortjournal = {Adv. Sci.}, title = {A human immuno-lung organoid model to study macrophage-mediated lung cell senescence upon SARS-CoV-2 infection}, volume = {12}, year = {2025}, }
• (2025). Mucociliary clearance inspired nanozyme-centric hydrogel composites for integrated bacterial detection. ADVS, 12(36), e03809. (www)

  @article{ , abstract = {The rapid movement of populations has led to the transmission and infection of pathogens, imposing a significant burden on global healthcare systems and economies. Despite considerable progress, current strategies heavily rely on specialized instruments or complex processing of bacterial samples. Inspired by pulmonary cilia and the mucus on it, a nanozyme-centric hydrogel network, integrated into nanowires for comprehensive bacterial lysis and detection. Nanozymes serve as multifunctional initiators and crosslinkers for the hydrogel network, enabling a one-step gelation process that addresses the aggregation issues of nanozyme particles, and improving the sensitivity of colorimetric detection. By integrating the nanozyme-centric hydrogel with the rapid piercing capabilities of the nanowire arrays, an efficient platform is developed for the disinfection, lysis, and detection of various bacterial strains. Moreover, this detection platform is adaptable to flexible substrates and can be integrated with machine learning algorithms, promoting versatile home-based pathogen testing in resource-limited settings.}, archive = {J_ADVS}, author = {Zhaoling Tan and Xuejiao Wang and Zhaoyue Wang and Jieke Jiang and Xi Yao}, doi = {10.1002/advs.202503809}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03809}, shortjournal = {Adv. Sci.}, title = {Mucociliary clearance inspired nanozyme-centric hydrogel composites for integrated bacterial detection}, volume = {12}, year = {2025}, }
• (2025). Neutrophil mobilization triggers microglial functional change to exacerbate cerebral ischemia-reperfusion injury. ADVS, 12(36), e03722. (www)

  @article{ , abstract = {Acute ischemic stroke is a leading cause of mortality and disability worldwide. Neuroinflammation following ischemia-reperfusion plays a critical role in the disease's pathogenesis. Neutrophil aggregation and clearance within the brain parenchyma influence neuroinflammatory damage during ischemic stroke. Microglia-mediated phagocytosis plays a pivotal role in mitigating neuroinflammation and promoting brain parenchyma recovery. However, the mechanisms underlying the cross-talk between neutrophils and microglia remain poorly understood. Here, this study demonstrates that neutrophils can trigger microglial functional change to inhibit microglial phagocytosis and promote pyroptosis, which is regulated by neutrophil-derived myeloid-related protein 14. Additionally, interleukin-1 β released by pyroptotic microglia further upregulates myeloid-related protein 14 expression and facilitates neutrophil mobilization from the bone marrow, establishing a self-sustaining inflammatory loop. Therefore, neutrophils accumulate in the brain parenchyma and further exacerbate microglial neuroinflammation in the ischemic brain. These findings reveal a previously unknown interaction between neutrophils and microglia after acute ischemic stroke and suggest that targeting myeloid-related protein 14 may provide a novel therapeutic strategy for ischemic stroke therapy.}, archive = {J_ADVS}, author = {Huijuan Jin and Zhifang Li and Senwei Tan and Qinghui Xiao and Qingcan Li and Jiao Ye and Yifan Zhou and Yan Wan and Qiang Liu and Bijoy K Menon and Bo Hu}, doi = {10.1002/advs.202503722}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03722}, shortjournal = {Adv. Sci.}, title = {Neutrophil mobilization triggers microglial functional change to exacerbate cerebral ischemia-reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). STING COPII ER export trafficking and signaling primed by phosphorylation switches. ADVS, 12(36), e03660. (www)

  @article{ , abstract = {Despite advances in understanding the STING signaling pathway, mechanisms governing cyclic GMP-AMP (cGAMP)-induced STING trafficking out of the endoplasmic reticulum (ER) remain unclear. This study reveals that STING localization is regulated by the balance between coat protein II (COPII)- and coat protein I (COPI)-mediated trafficking, maintaining ER residency in the inactive state or promoting transport to the cis -Golgi via enhanced COPII-mediated export upon activation. Two novel TANK-binding kinase 1 (TBK1)-regulated phosphorylated COPII sorting signals on STING—a conserved pSGME motif and a primate-specific pFS motif—are biochemically and structurally identified. These cGAMP-induced signals drive activated STING toward the ER-Golgi intermediate compartment (ERGIC) and the cis -Golgi complex. Using a cell-free COPII vesicle reconstitution system, TBK1 activation is shown to occur on COPII vesicles, while IRF3 phosphorylation is confined to the ERGIC or the cis -Golgi complex post-uncoating, due to the competitive binding of COPII Sec24 and IRF3 to phosphorylated STING. A class of compounds is also identified that attenuates IRF3 phosphorylation by inhibiting phosphorylated STING packaging into COPII vesicles. These findings elucidate STING trafficking mechanisms and offer therapeutic potential for diseases linked to dysregulated STING activation.}, archive = {J_ADVS}, author = {Yanan Nan and Dongxiao Cui and Jiajian Guo and Xiaojing Ma and Jiaming Wang and Linyue Guo and Tianyu Li and Mingrui Yang and Guangrui Huang and Anlong Xu and Wenfu Ma}, doi = {10.1002/advs.202503660}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03660}, shortjournal = {Adv. Sci.}, title = {STING COPII ER export trafficking and signaling primed by phosphorylation switches}, volume = {12}, year = {2025}, }
• (2025). An MOF-enhanced anti-fouling immunoprobe platform for efficient direct screening of pancreatic cancer. ADVS, 12(36), e03619. (www)

  @article{ , abstract = {Monitoring biomarkers offers insights for early disease (e.g., cancer, chronic diseases) screening, treatment guidance and response evaluation. To tackle challenges in precise biomarker detection in complex blood samples, we propose a metal-organic framework (MOF)-enhanced anti-fouling immunoprobe (MAIP). This sensing platform integrates several key features, including an anti-fouling surface, fully oriented antibody immobilization, and an enhanced electron transfer layer. This platform demonstrates remarkable sensitivity and specificity, capable of detecting trace concentrations of cancer markers, ranging from pg/mL to ng/mL. Comprehensive analysis of clinical serum samples, combined with machine learning (ML) evaluations, underscores the platform's reliability and effectiveness in cancer biomarker detection. Using a combination of three biomarkers, the algorithm demonstrated satisfactory classification performance with an accuracy of 100% on the test set across 64 serum samples. Moreover, when evaluated using 10-fold cross-validation, the optimized model maintained a robust accuracy of 0.955 ± 0.09, reinforcing its strong stability and good generalization ability across different data partitions. The MAIP-based platform developed here offers swift analysis, high accuracy, and a simplified testing process. This makes it a promising approach for directly profiling cancer markers from blood, thereby facilitating timely and effective patient care.}, archive = {J_ADVS}, author = {Wenjuan Yang and Shujuan Mao and Hao Zhu and Handong Yao and Wei Jin and Lingyan Feng and Xinghua Gao and Xuefeng Wang and Wei Chen and Min Tu and Yuan Zhang}, doi = {10.1002/advs.202503619}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03619}, shortjournal = {Adv. Sci.}, title = {An MOF-enhanced anti-fouling immunoprobe platform for efficient direct screening of pancreatic cancer}, volume = {12}, year = {2025}, }
• (2025). Smart health evaluation for lithium-ion battery with super-short-segment charging. ADVS, 12(36), e03583. (www)

  @article{ , abstract = {Accurate state of health estimation is crucial for the reliable operation of lithium-ion batteries in electric vehicles. The charging curve contains valuable features for health evaluation, but real-world charging often lacks sufficient data due to the users’ early recharging habits. A smart method is proposed for accurate battery health estimation using super-short charging segments. This method combines a degradation mechanism-guided Scale-Invariant Feature Transform for smart health feature identification with machine learning for health evaluation. Validation with 87 batteries with various chemistries, formats, and capacities from 6 manufacturers demonstrates its efficacy. Regardless of battery specifications, health features can be identified automatically from the charging data. The method promises high accuracy (estimation error as low as 1.97%) even with super-short charging covering 10% state of charge span, where all the existing health feature extraction approaches fail. This method provides new avenues for battery health evaluation in uncertain real-world electric vehicle applications.}, archive = {J_ADVS}, author = {Qinghua Li and Zhongbao Wei and Hongwen He and Jun Shen and Yang Li and Xiaoguang Yang and Mahinda Vilathgamuwa}, doi = {10.1002/advs.202503583}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03583}, shortjournal = {Adv. Sci.}, title = {Smart health evaluation for lithium-ion battery with super-short-segment charging}, volume = {12}, year = {2025}, }
• (2025). Highly conductive liquid metal emulsion gels for three-dimensionally printed stretchable electronics. ADVS, 12(36), e03449. (www)

  @article{ , abstract = {Gallium-based liquid metals are promising for stretchable electronics due to their inherent deformability and excellent conductivity. However, the lack of a scalable and automated fabrication process has limited their practical applications. This study introduces a two-step method to create liquid metal emulsion gels suitable for 3D printing, characterized by densely packed liquid metal microcapsules within polymer matrices. The resulting emulsion gel demonstrates favorable rheological properties for 3D printing and minimal shrinkage through solidification. With a substantial fraction of sizable microcapsules, the printed features can be activated into compliant conductors with exceptional conductivity of ≈2.2× 10 4 S cm −1 and an ultrahigh stretchability of up to ≈1000% strain. Stretchable lighting emitting diode displays and near field communication tags are successfully fabricated through 3D printing to demonstrate the practicality of liquid metal microcapsule gels. These developments provide a versatile platform to design liquid metal inks for printed stretchable electronics.}, archive = {J_ADVS}, author = {Qianying Lu and Ting Fang and Chenyang Ye and Yanyan Li and Ming Wu and Yuping Sun and Desheng Kong and Xiaoliang Wang and Yan-qing Lu}, doi = {10.1002/advs.202503449}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03449}, shortjournal = {Adv. Sci.}, title = {Highly conductive liquid metal emulsion gels for three-dimensionally printed stretchable electronics}, volume = {12}, year = {2025}, }
• (2025). A myelin debris cleaner for spinal cord injury recovery: Polycaprolactone / cell membrane assembled scaffolds. ADVS, 12(36), e03269. (www)

  @article{ , abstract = {After spinal cord injury (SCI), a mass of myelin debris derived from injured myelin sheath will be consistently generated and induce macrophages to be foam cells. It has been established that myelin debris and foam cells are negative on SCI recovery through direct and indirect neurotoxicity. Different from previous studies, the present research utilized efficient biological composite materials to adsorb myelin debris, exploring new avenues for solving foam cells and myelin debris following SCI. To achieve the strategy, the present author team has developed the biomaterial composed of polycaprolactone (PCL) nanofiber and pretreated macrophage membranes. Results in vitro and in vivo showed that the composite biomaterial effectively adsorbed myelin debris, with a result of few remaining foam cells, mitigated inflammation, minimal scarring, and favorable motor function recovery. Moreover, lipidomics and proteomics, from a metabolic perspective, further demonstrated the regulatory role of the composite biomaterial in myelin debris. Taken together, the composite biomaterial can effectively promote SCI recovery, which provides a novel insight for the treatment of SCI.}, archive = {J_ADVS}, author = {Yuchen Zhou and Tao Xu and Yiyan Zhou and Nuo Chen and Zhengchao Wu and Zongze Yang and Changwei Yang and Xiaoqing Chen}, doi = {10.1002/advs.202503269}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03269}, shortjournal = {Adv. Sci.}, title = {A myelin debris cleaner for spinal cord injury recovery: Polycaprolactone / cell membrane assembled scaffolds}, volume = {12}, year = {2025}, }
• (2025). Oscillating magnetic field induced bone injury repair by using drug-free micromotors. ADVS, 12(36), e03254. (www)

  @article{ , abstract = {Bone injury repair remains a significant clinical challenge due to the tissue's limited self-healing capacity and the complex physiological environment at the defect site. Factors such as insufficient vascularization, poor retention of therapeutic agents, and the lack of effective mechanical stimulation further hinder the success of current minimally invasive treatments, which often rely on the delivery of drugs or stem cells. Here, magnetic gelatin/hyaluronic acid composite hydrogels micromotors are developed, capable of promoting bone regeneration through localized micromovement stimulation, eliminating the need for therapeutic payloads. By harnessing the mechanical forces generated by the micromotors under an oscillating magnetic field, the approach directly enhances osteoblast proliferation and differentiation, providing a novel mechanism for bone repair. The efficacy of this strategy is further validated in vivo using animal models of bone defects, where moderate micromovement stimulation is shown to significantly increase the volume fraction of newly formed bone by approximately twofold, accompanied by well-aligned collagen and organized mineralization, thereby demonstrating substantial regenerative effects. This work presents a paradigm shift in bone repair with a payload-free, minimally invasive solution that overcomes conventional limitations and offers new insights into microrobotics in regenerative medicine.}, archive = {J_ADVS}, author = {Jie Shen and Rui He and Jiajun He and Lipeng Liao and Yongcan Huang and Shaoxiong Min and Xiaoreng Feng and Bin Chen and Ben Wang}, doi = {10.1002/advs.202503254}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03254}, shortjournal = {Adv. Sci.}, title = {Oscillating magnetic field induced bone injury repair by using drug-free micromotors}, volume = {12}, year = {2025}, }
• (2025). A promising point-of-care testing strategy: Ultrasmooth gold nanogroove arrays biosensor combined with initial rate analysis. ADVS, 12(36), e03056. (www)

  @article{ , abstract = {Nowadays, plasmonic biosensors have achieved the limit of detection (LOD) far beyond the clinical or professional standards in the sensing field through material and structural optimizations. However, it remains predominantly a research tool due to the challenge to simultaneously achieve mass production, ultrasensitive and rapid detection, high-reproducibility, and ease of integration, which are extremely desired in point-of-care testing (POCT)-based commercial products. Here, a label-free, ultrasensitive, and rapid assay protocol is described for quantitative protein detections in serum samples, which integrates an ultrasmooth gold nanogroove arrays (UGNA) biosensor with an initial rate analysis (IRA) method. i) Compared with the existing plasmonic biosensors, miscellaneous-protein-mixed scheme substantially accelerates the binding kinetics of analytes by passivation of all channel inner surfaces. Combined with the IRA method, a wide linear range of AFP detection (1–10 4 ng mL −1 ) is obtained, and an enhancement factor of ≈160-fold in detection time (≈70 s) is achieved for an analyte with ultralow concentration. ii) UGNA can achieve an extremely high surface figure of merit (FOM surf ) under normal incidence, which is immensely useful for miniaturization and multiplexing. iii) UGNA are fabricated using a high-reproducibility template-stripping technique, which potentially enables low-cost mass production. These unique advantages suggest that the biosensor system and analysis method have tremendous potential in POCT biosensing devices.}, archive = {J_ADVS}, author = {Yi Liu and Shan Xing and Zhan Si and Kai He and Manchun Zheng and Yang Shen and Chongjun Jin}, doi = {10.1002/advs.202503056}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03056}, shortjournal = {Adv. Sci.}, title = {A promising point-of-care testing strategy: Ultrasmooth gold nanogroove arrays biosensor combined with initial rate analysis}, volume = {12}, year = {2025}, }
• (2025). Training-free regulation of grasping by intracortical tactile feedback designed via s1-m1 communication. ADVS, 12(36), e03011. (www)

  @article{ , abstract = {Tactile feedback is essential for grip force control when operating a neuroprosthesis. Due to limited knowledge of cortical sensorimotor coordination, artificial feedback is mostly counterintuitive, requiring training to be associated with grasping behaviors. The current study investigates sensorimotor communication by recording neural activities from the primary sensory cortex (S1) and the primary motor cortex (M1) while macaques grasp targets of various textures and loads. Intracortical micro-stimulation is also delivered to S1 to validate the intervention of sensorimotor communication in grasping. The findings identify an S1→M1 functional pathway through which tactile information is transferred. The pathway is shared by both natural and artificial neural propagations. Moreover, it is demonstrated that sensory and motor decoding of neural activities in M1, as well as the actual grip force, are modulated by stimulation designed via S1→M1 communication, without prior training. The work provides a biomimetic strategy to design intuitive haptic feedback for brain-machine interfaces utilizing the S1→M1 pathway.}, archive = {J_ADVS}, author = {Qi Zhang and Bing Liu and Zhemeng Wang and Jiayue Zhou and Xingyi Yang and Qian Zhou and Yuwei Zhao and Siwei Li and Jin Zhou and Changyong Wang}, doi = {10.1002/advs.202503011}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e03011}, shortjournal = {Adv. Sci.}, title = {Training-free regulation of grasping by intracortical tactile feedback designed via s1-m1 communication}, volume = {12}, year = {2025}, }
• (2025). Macrophage-mediated transport of insoluble indirubin induces hepatic injury during intestinal inflammation. ADVS, 12(36), e02993. (www)

  @article{ , abstract = {Many plant-derived bioactive molecules with low solubility and permeability can cause hepatocyte injury. However, the mechanism by which they induce hepatic damage without passive diffusion into the hepatic circulatory system remains unclear. This study demonstrate that indirubin, the main component of indigo naturalis with poor aqueous solubility, predisposes mice with chronic colitis to hepatic injury. This closely mimics the hepatic damage commonly observed in ulcerative colitis patients treated with indigo naturalis. Upon administration, indirubin is detected in the plasma, Peyer's patches, and hepatic tissue, with its distribution linked to macrophage infiltration into the liver. Ablation of macrophages significantly reduces indirubin accumulation and attenuates elevated hepatic transaminases in mice with chronic colitis. Mechanistically, macrophages internalize and transport indirubin aggregates from Peyer's patches through the circulatory system to the livers. This internalization activates the NLRP3 inflammasome, leading to the formation of macrophage extracellular traps (METs), which contribute to oxidative stress-induced liver injury. The study identifies indirubin as a potentially toxic component of indigo naturalis that provokes METs-mediated oxidative damage. Additionally, the findings reveal a novel transport pathway for poorly soluble molecules to reach the liver via uptake by macrophages within Peyer's patches.}, archive = {J_ADVS}, author = {Yiqi Xu and Jingchun Shi and Heung-Lam Mok and Cheng Lyu and Junbang Chen and Chunhua Huang and Hongyan Qin and Chengyuan Lin and Hor-Yue Tan and Zhaoxiang Bian}, doi = {10.1002/advs.202502993}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e02993}, shortjournal = {Adv. Sci.}, title = {Macrophage-mediated transport of insoluble indirubin induces hepatic injury during intestinal inflammation}, volume = {12}, year = {2025}, }
• (2025). TaPPR13, a pentatricopeptide repeat protein gene activated by TaBZR2, confers drought stress tolerance by enhancing the antioxidant defense system and promoting retrograde signaling in wheat (Triticum aestivum). ADVS, 12(36), e02984. (www)

  @article{ , abstract = {The wheat ( Triticum aestivum ) brassinazole-resistant 2 ( TaBZR2 ) gene is identified as significantly associated with drought tolerance by genome-wide association study (GWAS), and a chloroplast pentatricopeptide repeat (PPR) protein gene TaPPR13 functioned as a positive drought stress regulator downstream of TaBZR2. Overexpression of TaPPR13 enhanced the antioxidative defense system, whereas knockdown of TaPPR13 led to the accumulation of reactive oxygen species (ROS) and caused abnormalities in chloroplast thylakoids under drought stress conditions. RNA-seq analysis showed that overexpression of TaPPR13 significantly upregulated the expression of nuclear-encoded genes involved in ROS scavenging and the abscisic acid (ABA) signaling pathway. Furthermore, TaPPR13 interacted with TaAOR1 and TaSIG5 to facilitate detoxification and regulate chloroplast gene expression, thereby enhancing drought tolerance. Overexpression of TaPPR13 and TaAOR1 mediated stomatal closure to reduce water loss, improving photosynthetic capacity and conferring a yield advantage under drought stress. These findings show that TaPPR13 promotes retrograde signaling to alter nuclear gene expression, with the TaBZR2-TaPPR13-TaAOR1/TaSIG5 module representing a novel signaling pathway that likely plays a pivotal role in drought stress response.}, archive = {J_ADVS}, author = {Ze-Hao Hou and Wei-Jun Zheng and Lei Zheng and Jing-Yue Wang and Shuang-Xi Zhang and Ji-Tong Wei and Shu-Hui Yang and Yuan-Chen Jiao and Wen-Jing Cheng and Tai-Fei Yu and Xiao-Fei Ma and Jing-Na Ru and Yong-Wei Liu and Xin-You Cao and Jun Chen and Yong-Bin Zhou and Ming Chen and Li-Hui Li and You-Zhi Ma and Xiao-Jun Nie and Zhao-Shi Xu}, doi = {10.1002/advs.202502984}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e02984}, shortjournal = {Adv. Sci.}, title = {TaPPR13, a pentatricopeptide repeat protein gene activated by TaBZR2, confers drought stress tolerance by enhancing the antioxidant defense system and promoting retrograde signaling in wheat (Triticum aestivum)}, volume = {12}, year = {2025}, }
• (2025). Drug resistance predictions based on a directed flag transformer. ADVS, 12(36), e02756. (www)

  @article{ , abstract = {The evolving SARS-CoV-2 virus threatens global public health, particularly with potential resistance to PAXLOVID, whose active ingredient, nirmatrelvir, targets the viral main protease (Mpro). CAPTURE (direCted flAg laPlacian Transformer for drUg Resistance prEdictions) is developed to assess Mpro mutations' impact on nirmatrelvir binding and identify drug-resistant variants. CAPTURE integrates a mutation analysis with a resistance prediction module using DFFormer-seq, a novel ensemble model combining a Directed Flag Transformer and sequence embeddings. Analysis of Mpro mutations from May to December 2022 revealed increasing mutation frequencies near the binding site, suggesting PAXLOVID's widespread use accelerated drug-resistant evolution. CAPTURE identified potential resistance mutations, including experimentally confirmed H172Y and F140L, and five others awaiting validation. Evaluated on Mpro mutant data, CAPTURE achieved 57% recall and 71% precision in predicting drug-resistant mutations. This work establishes a robust framework for predicting resistance and enabling real-time viral surveillance, guiding the design of next-generation therapeutics.}, archive = {J_ADVS}, author = {Dong Chen and Gengzhuo Liu and Hongyan Du and Benjamin Jones and Junjie Wee and Rui Wang and Jiahui Chen and Jana Shen and Guo-Wei Wei}, doi = {10.1002/advs.202502756}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e02756}, shortjournal = {Adv. Sci.}, title = {Drug resistance predictions based on a directed flag transformer}, volume = {12}, year = {2025}, }
• (2025). Regenerative hair pigmentation via skin organoids: Adaptive patterning mediated by collagen VI and semaphorin 3C. ADVS, 12(36), e02436. (www)

  @article{ , abstract = {The color patterns of mammalian fur are determined by melanocytes' ability to respond to and adapt to microenvironmental cues. However, these patterns can be lost following injury or under pathological conditions, and the underlying biological mechanisms remain poorly understood. In this study, reconstituted hair-bearing skin is generated using skin organoids derived from dissociated epidermal cells, dermal cells, and melanocyte progenitors. The reconstituted skin exhibited pigmented hair patterns. By investigating the molecular cues involved in re-establishing pigment patterns, it is demonstrated that this process is regulated through a two-step mechanism. First, during skin organoid culture, signaling from dermal fibroblasts to melanocytes via the COL6A3-CD44 pathway promotes the early maintenance of organotypic melanocytes. Subsequently, during hair follicle morphogenesis after skin organoid transplantation, signaling from the bulge to melanocytes via the SEMA3C-NRP1 pathway regulates microtubule stability. This regulation guides melanocytes to migrate to their bulge stem cell niche, thereby enhancing hair pigmentation by promoting the adaptive patterning of melanocytes within the hair follicle. The study reveals two novel signaling mechanisms that shape melanocyte adaptive patterning and highlight the hair follicle as a regulatory hub for melanocyte physiological behaviors. These findings may inspire new clinical strategies for preventing hair greying.}, archive = {J_ADVS}, author = {Tingting Li and Xinzhu Li and Xiao Xiang and Jundong Huang and Xinyu Shen and Mengyue Wang and Jingwei Jiang and Shiwen Shao and Zeming Li and Tian Xie and Deming Liu and Yiping Zhao and Rui Ma and Wenyu Wu and Wei Shi and Cheng-Ming Chuong and Ji Li and Mingxing Lei}, doi = {10.1002/advs.202502436}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e02436}, shortjournal = {Adv. Sci.}, title = {Regenerative hair pigmentation via skin organoids: Adaptive patterning mediated by collagen VI and semaphorin 3C}, volume = {12}, year = {2025}, }
• (2025). Long term high-salt diet induces cognitive impairments via down-regulating SHANK1. ADVS, 12(36), e02099. (www)

  @article{ , abstract = {High-salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear. This study reveals that HS diet reduces SHANK1, a key postsynaptic scaffolding protein, via downregulation of the PKA/CREB pathway, leading to synaptic dysfunction and cognitive deficits in rats. RNA sequencing of HS-fed rat hippocampi showed downregulation of cAMP signaling and SHANK1 expression. Pharmacological inhibition of PKA/CREB reduced SHANK1 levels and impaired dendritic structure and synaptic function, while PKA activation restored CREB activity and SHANK1 expression, reversing HS-induced deficits. Notably, CREB activation is essential for SHANK1 regulation, as a CREB mutant (S133A) blocked the effects of PKA activation, and a constitutively active CREB (S133D) prevented SHANK1 downregulation. These findings highlight the PKA/CREB/SHANK1 pathway as a potential therapeutic target for HS-induced cognitive dysfunction.}, archive = {J_ADVS}, author = {Cuiping Guo and Yuanyuan Li and Wensheng Li and Tongrui Wu and Yi Liu and Yacoubou Abdoul Razak Mahaman and Jianzhi Wang and Rong Liu and Wei Liu and Hui Shen and Xiaochuan Wang}, doi = {10.1002/advs.202502099}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e02099}, shortjournal = {Adv. Sci.}, title = {Long term high-salt diet induces cognitive impairments via down-regulating SHANK1}, volume = {12}, year = {2025}, }
• (2025). Anti-inflammatory mechanisms of selenium nanosheets in ulcerative colitis: Protein corona, GP130 interaction, and transcriptomic profile. ADVS, 12(36), e01832. (www)

  @article{ , abstract = {Ulcerative colitis (UC) is a complex inflammatory bowel disease characterized by multiple factors. Alleviating inflammation is the primary therapeutic approach. However, currently employed anti-inflammatory treatments have limited efficacy and cause side effects. Safer, more effective therapies are needed. Selenium nanosheets (SeNSs) are biocompatible, anti-inflammatory, and low-toxicity nanomaterials with high surface areas and abundant active sites, making them potential therapeutic agents for UC. This study indicates that SeNSs can interact with macrophages and adhere to their cell membranes, significantly increasing their internalization into cells. Proteomic analysis reveals that the main components of the SeNS protein corona are proteins involved in cell proliferation and migration, including those associated with the AKT/PI3K and NF-κB signaling pathways. SeNSs hydrophobically interact with GP130, inhibiting its expression. This interaction downregulates the proteins involved in the aforementioned pathways. In addition, a transcriptomic analysis confirms that SeNSs inhibit apoptosis, cytokine–cytokine receptor interactions, and the chemokine and TNF signaling pathways. In dextran sulfate sodium (DSS)-induced UC model mice, SeNSs significantly decrease IL-1β, IL-6, and TNF-α levels, alleviate tissue damage, and lower the disease activity index. These findings suggest that SeNSs can be a safe and effective treatment strategy for UC, offering a novel approach for managing inflammatory diseases.}, archive = {J_ADVS}, author = {Dingyi Shen and Li Gong and Wei Yang and Jiaqi Luo and Zhen Jin and Youzhi Tang}, doi = {10.1002/advs.202501832}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e01832}, shortjournal = {Adv. Sci.}, title = {Anti-inflammatory mechanisms of selenium nanosheets in ulcerative colitis: Protein corona, GP130 interaction, and transcriptomic profile}, volume = {12}, year = {2025}, }
• (2025). Harnessing the immunomodulation of UV-exposed keratinocyte extracellular vesicles for inflammatory disorder treatment. ADVS, 12(36), e01517. (www)

  @article{ , abstract = {Sunbathing excessively heightens the risk of skin carcinogenesis due to ultraviolet (UV)-mediated immunosuppression. Keratinocytes, the primary cells in epidermis, play a pivotal role in orchestrating the UV-induced immunosuppressive response by releasing platelet-activating factor (PAF) upon UV exposure. Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV-irradiated keratinocytes. To safely exploit this mechanism, extracellular vesicles are isolated from UV-irradiated keratinocytes, designate UV KEV, and assess their potential as immunomodulatory agents in the mouse model of inflammatory bowel disease (IBD) and imiquimod (IMQ)-induced psoriasis. Subcutaneous administration of UV KEV efficiently stimulates the secretion of prostaglandin E 2 (PGE 2 ) by keratinocytes and promotes the migration of mast cells to lymph nodes through the PAF/PAF receptor pathway. The as-prepared UV KEV effectively reshapes the immune landscape within the spleen by inhibiting dendritic cell maturation and increasing the population of regulatory T cells. Animal studies confirm that UV KEV can result in robust systemic immune tolerance and significantly alleviate the symptoms of both IBD and psoriasis. This study presents the possibility of UV KEV as natural immunoregulatory therapeutics for the managing inflammatory disorders with promising clinical potential.}, archive = {J_ADVS}, author = {Lu Liu and Ding Yang and Jingsen Ji and Gengyou Li and Haoting Chen and Yuying Yao and Chenxing Fu and Fangling Liao and Jinzhao Liu and Yaming Zhang and Zechuan Li and Jing Zhang and Huike Ma and Jingxia Zhao and Ying-Shi Sun and Weisheng Guo and Weiping Wang}, doi = {10.1002/advs.202501517}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e01517}, shortjournal = {Adv. Sci.}, title = {Harnessing the immunomodulation of UV-exposed keratinocyte extracellular vesicles for inflammatory disorder treatment}, volume = {12}, year = {2025}, }
• (2025). METTL3/ALKBH5-mediated n6-methyladenosine modification drives macrophage m1 polarization via the SLC15A3-TASL-IRF5 signaling axis in psoriasis. ADVS, 12(36), e01408. (www)

  @article{ , abstract = {Impaired N6-methyladenosine (m 6 A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear. Here, m 6 A modification and its methyltransferase METTL3 are revealed to be upregulated in psoriatic macrophages, while the demethylase ALKBH5 is downregulated. Conditional knockout of Mettl3 in macrophages alleviated psoriasis-like symptoms in mice, whereas knockout of Alkbh5 exacerbated them. Both in vivo and in vitro, Mettl3 deficiency inhibited IMQ-induced M1 macrophage polarization, while Alkbh5 deficiency promoted M1 polarization. The regulation of macrophage polarization by m 6 A is likely mediated by targeting Slc15a3 . SLC15A3 enhances the recruitment of TASL, a recently identified endolysosomal IRF5 adaptor, which functions similarly to the IRF3 adaptors STING and MAVS at the endoplasmic reticulum (ER) and mitochondria, respectively, to augment IRF5 signaling via SLC15A4. The findings underscore the critical role of m 6 A RNA modification in psoriasis pathogenesis and unveil a novel regulatory mechanism of TASL-IRF5 signaling through m 6 A modification, suggesting potential new therapeutic targets for psoriasis treatment.}, archive = {J_ADVS}, author = {Tao Huang and Shijun Chen and Ke Ding and Liyan Yuan and Weiqi Lv and Kechen Chen and Yuchen Liu and Dongzhao Ma and Xin Zhang and Xiaobo Wang and Guanzheng Luo and Bin Yang and Ying Lin and Zhili Rong}, doi = {10.1002/advs.202501408}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e01408}, shortjournal = {Adv. Sci.}, title = {METTL3/ALKBH5-mediated n6-methyladenosine modification drives macrophage m1 polarization via the SLC15A3-TASL-IRF5 signaling axis in psoriasis}, volume = {12}, year = {2025}, }
• (2025). Remodeling the physicochemical and pharmacokinetic properties of PROTAC via lipid nanodisks for cancer therapy. ADVS, 12(36), e01384. (www)

  @article{ , abstract = {Proteolysis targeting chimera (PROTAC), as an emerging approach for target protein degradation based on the intracellular ubiquitin-protease system, is characterized by catalytic and reusability over traditional inhibitors. However, PROTACs are fraught with pharmacokinetic dangers due to poor water solubility and membrane permeability, further posing a huge challenge to the clinical potential. Herein, a nanodelivery system is developed that is elaborately decorated with prodrugs to improve the physicochemical properties and therapeutic efficacy of PROTAC. The nanodelivery, lipid nanodisk (LND), is readily assembled from three commercially available phospholipids, and shows high stability and long circulation time in vivo. The lipid-derived prodrug realizes prolonged retention and precise release of PROTACs at tumor sites under the endogenous stimulus. Collectively, the LND loaded with MZ1 prodrug (LND-MZ1) presents enhanced biocompatibility, improves intracellular accumulation, and superior tumor penetration capacity, enabling more potent and targeted PROTAC therapy with enhanced specificity in vivo. LND-MZ1 shows a more significant anti-tumor effect in the xenograft tumor model, even at a one-tenth dose of the parent PROTACs under the same therapeutic schedule. Overall, the LND-based nanomedicine paves the way for remodeling the physicochemical and pharmacokinetic properties of various drugs to expand the therapeutic scope.}, archive = {J_ADVS}, author = {Meichen Pan and Chunrong Yang and Zhongliang Fu and Yuchen Yang and Ying Zhuo and Hongwei Hou and Jinghong Li}, doi = {10.1002/advs.202501384}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e01384}, shortjournal = {Adv. Sci.}, title = {Remodeling the physicochemical and pharmacokinetic properties of PROTAC via lipid nanodisks for cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Engineered probiotic-powered micro-rod robot bomb for thrombus-penetrating explosion. ADVS, 12(36), e01304. (www)

  @article{ , abstract = {Conventional thrombolytic agents demonstrated limited efficacy in treating thrombotic disorders characterized by narrow therapeutic windows and progressive vascular injury, lacking the required precision, timeliness, and treatment durability. Here an engineered probiotic powered micro-rod robot for targeted and penetrative treatment for thrombus is developed. This micro-rod robot ( Sr EcN PL ) using natural probiotics as bio-carriers, functionalized with thrombolytic carbon nanotubes and platelet membrane-coated nanoparticles loaded with targeted vasodilators. The robot exploits the rapid movement of probiotics, combined with the active targeting ability of the platelet membrane, to achieve rapid and precise drug delivery to thrombus tissue. Based on the natural rod-shaped structure of probiotics, Sr EcN PL can deeply penetrate thrombus tissue, achieving faster thrombolysis efficiency. The thrombolytic micro-robot combines thrombus-targeting capability with prolonged circulation time and controlled vasodilation, maintaining vascular patency and inhibiting secondary thrombus. Results indicate that this micro-robot can quickly and accurately target and penetrate thrombus tissue, extending the biological half-life of thrombolytic drugs by ≈332 times and enabling sustained thrombolysis. This novel dual-pronged combined thrombolytic therapy has significant scientific implications for treating thrombotic diseases with narrow therapeutic windows caused by vascular injury.}, archive = {J_ADVS}, author = {Riyue Liu and Jiale Chen and Yuanyuan Li and Nawsherwan and Cuilian Dai and Yan Wang and Jinrong Zheng and Kecheng Zhou and Mangmang Sang}, doi = {10.1002/advs.202501304}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e01304}, shortjournal = {Adv. Sci.}, title = {Engineered probiotic-powered micro-rod robot bomb for thrombus-penetrating explosion}, volume = {12}, year = {2025}, }
• (2025). Gastrula-premarked posterior enhancer primes posterior tissue development through cross-talk with TGF-β signaling pathway. ADVS, 12(36), e00895. (www)

  @article{ , abstract = {The regulatory mechanisms governing cell fate determination, particularly lineage diversification during mammalian embryonic development, remain poorly understood with in-depth regulatory paradigms yet to be fully elucidated. Here, leveraging the epigenetic landscape of mouse gastrula, p-Enh is identified, an enhancer located within the first intron of Cdx2 and epigenetically pre-marked in the primitive streak region, as a pivotal regulator for posterior tissue development in mouse embryos. Morphological and single-cell transcriptomic analyses confirmed embryonic lethality phenotype with disrupted posterior tissue development trajectories in p-Enh-KO embryos. Molecularly, apart from regulating the neighboring coding-gene Cdx2 in cis , the findings suggest that p-Enh also modulates the global transcriptome and epigenomic landscape, which might through the transient production of eRNA in trans . Further investigation revealed p-Enh-derived eRNAs participate in the regulatory cascades of TGF-β signaling by directly interacting with SMAD4 protein. Combinatorial modulation of TGF-β signaling and p-Enh-eRNA abundance can largely rescue the posterior development deficiency in in vitro gastruloids through a Cdx2 -independent mechanism. Thus, a potential model is proposed in which the broadly distributed p-Enh transcripts within the nucleus can serve as essential cross-modular coordinators, priming the posterior development of mouse embryo.}, archive = {J_ADVS}, author = {Yingying Chen and Fengxiang Tan and Qing Fang and Lin Zhang and Jiaoyang Liao and Penglei Shen and Yun Qian and Mingzhu Wen and Rui Song and Yonggao Fu and He Jax Xu and Ran Wang and Cheng Li and Zhen Shao and Jinsong Li and Naihe Jing and Xianfa Yang}, doi = {10.1002/advs.202500895}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e00895}, shortjournal = {Adv. Sci.}, title = {Gastrula-premarked posterior enhancer primes posterior tissue development through cross-talk with TGF-β signaling pathway}, volume = {12}, year = {2025}, }
• (2025). The evolutionary trajectory and prognostic value of GITR+ tregs reprogramed by tumor-intrinsic PD-1/c-MET signaling in pancreatic cancer. ADVS, 12(36), e00806. (www)

  @article{ , abstract = {Tumor-intrinsic programmed cell death 1 (PD-1) has been shown to activate the mesenchymal epithelial transition factor (MET) pathway via its phosphorylation in pancreatic ductal adenocarcinoma (PDAC). However, the immunoregulatory consequences of MET activation remain poorly understood. Herein, a significant positive correlation between phosphorylated MET (p-MET) and tumor-intrinsic PD-1 is verified, both of which are independently associated with adverse prognosis. Elevated p-MET levels correlated with diminished CD8 + T cell cytotoxicity and increased regulatory T cell (Treg) infiltration. Single-cell RNA sequencing revealed MET activation selectively drives the accumulation of intratumoral GITR⁺ Tregs—a distinct effector Treg subset with potent immunosuppressive function and high prognostic relevance. Compared to KLF2⁺ naïve Tregs, GITR⁺ Tregs exhibited an activated phenotype and enhanced expression of immunoregulatory markers. Subgroup analysis further demonstrated that elevated GITR⁺ Treg infiltration diminished the prognostic utility of serum CA19-9, underscoring the immunosuppressive dominance of this Treg subset. Mechanistically, MET–IL-23–STAT4 axis orchestrates GITR⁺ Treg-mediated immune evasion in PDAC. In vivo, MET inhibition and GITR agonism synergize to enhance antitumor immunity in an orthotopic PDAC model. Collectively, these findings highlight MET signaling and GITR⁺ Tregs as actionable targets to counteract immune evasion and improve the efficacy of immunotherapeutic strategies in PDAC.}, archive = {J_ADVS}, author = {Jiande Han and Hanlin Yin and Taochen He and Junyi He and Zhenlai Jiang and Qiangda Chen and Zhihang Xu and Yuqi Xie and Yaolin Xu and Haibo Wang and Wenquan Wang and Wenchuan Wu and Yun Jin and Wenhui Lou and Jun Yu and Ning Pu and Liang Liu}, doi = {10.1002/advs.202500806}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e00806}, shortjournal = {Adv. Sci.}, title = {The evolutionary trajectory and prognostic value of GITR+ tregs reprogramed by tumor-intrinsic PD-1/c-MET signaling in pancreatic cancer}, volume = {12}, year = {2025}, }
• (2025). NSP7 molecular degrader attenuates coronaviral infection through the β-TrCP1/FBXO5 axis. ADVS, 12(36), e00798. (www)

  @article{ , abstract = {NSP7 (Non-Structural Protein 7) of SARS-CoV-2 is a crucial component for viral replication and transcription. In this study, it is revealed that the host E3 ubiquitin ligase FBXO5 suppresses viral replication by mediating NSP7 lysine-48-linked ubiquitination and subsequent proteasomal degradation. Interestingly, it is also determined that NSP7 expression impairs the host antiviral response by inhibiting the ISGylation of melanoma differentiation-associated protein 5 (MDA5), a key sensor for viral RNA. Through an unbiased esiRNA screen, it is identified that NSP7 ubiquitination is coregulated by β-TrCP1 and the kinase TAF1. Additionally, this study uncovers a small molecule FBXO5 stabilizer that disrupts the β-TrCP1–FBXO5 interaction, thereby markedly enhancing NSP7 degradation and effectively mitigating SARS-CoV-2 infection. Taken together, the findings reveal a novel mechanism for NSP7 regulation and suggest that small-molecule activators of the E3 ubiquitin ligase FBXO5 represent a promising new class of host-directed antiviral therapies.}, archive = {J_ADVS}, author = {Yao Tong and Travis B. Lear and Ferhan Tuncer and John J. Villandre and Áine N. Boudreau and Bo Lin and Irene Alfaras and Jason R. Kennerdell and Daniel P. Camarco and Mads B. Larsen and Yun Hua and Yanwen Chen and Meigin E. Chandler and Ricardo Pineda and Simon M. Barratt-Boyes and John W. Evankovich and Toren Finkel and Yuan Liu and Bill B. Chen}, doi = {10.1002/advs.202500798}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e00798}, shortjournal = {Adv. Sci.}, title = {NSP7 molecular degrader attenuates coronaviral infection through the β-TrCP1/FBXO5 axis}, volume = {12}, year = {2025}, }
• (2025). Inhibition of phosphodiesterase 10A by MP-10 rescues behavioral deficits and normalizes microglial morphology and synaptic pruning in a mouse model of FOXP1 syndrome. ADVS, 12(36), e00623. (www)

  @article{ , abstract = {FOXP1 syndrome caused by FOXP1 haploinsufficiency is characterized by intellectual disability, speech, and language impairment, autistic features, and neuropsychiatric abnormalities such as anxiety and hyperactivity. Behavioral changes in patients are mirrored in Foxp1 ± mice. It is shown that decreased Foxp1 in the Foxp1 ± striatum results in a significant decrease in phosphodiesterase 10a (Pde10a). Predominantly expressed in medium spiny neurons (MSNs), Pde10a modulates basal ganglia circuitry. Furthermore, the Foxp1 ± striatum exhibits microglial activation, reduced synaptic pruning, and dysregulation of 111 inflammatory genes. These include the downregulated P2ry12 and Fcrls , markers of homeostatic microglia, and upregulated Cd74 , a marker of reactive microglia, suggesting that neuroinflammation contributes to the observed deficits. Interestingly, treatment of Foxp1 ± mice with the PDE10A antagonist MP-10 (PF-2545920) immediately after birth not only corrects behavioral abnormalities, including decreased ultrasonic vocalization, hyperactivity, and anxiety but also normalizes changes in microglia morphology and synaptic pruning. Transcriptomic analysis with a neuroinflammation-specific gene panel reveals nominal gene expression changes after MP-10 treatment, including Bdnf upregulation and enrichment of neurotrophin signaling. Since FOXP1 and its signaling pathway are highly conserved, administration of MP-10 or other Pde10a antagonists may also alleviate the neurological dysfunction seen in humans with FOXP1 syndrome.}, archive = {J_ADVS}, author = {Henning Fröhlich and Jing Wang and Ferdinand Althammer and Tim Schubert and Nina Kluck and Valery Grinevich and Stefanie Schmitteckert and Christian P. Schaaf and Gudrun A. Rappold}, doi = {10.1002/advs.202500623}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e00623}, shortjournal = {Adv. Sci.}, title = {Inhibition of phosphodiesterase 10A by MP-10 rescues behavioral deficits and normalizes microglial morphology and synaptic pruning in a mouse model of FOXP1 syndrome}, volume = {12}, year = {2025}, }
• (2025). Novel antimicrobial protein fibroblast growth factor 8 accelerates skin wound healing via directly inhibiting bacteria and activating glycolysis. ADVS, 12(36), e00388. (www)

  @article{ , abstract = {Repairing and preventing infections of skin wounds are crucial for the body health. Fibroblast growth factors (FGFs) have functions of repairing skin wounds, while antimicrobial peptides/proteins (AMPs) can prevent the infections of skin. Therefore, if FGFs can act like AMPs, they will have better application potential in promoting skin wound healing. Here, it is found that grass carp fibroblast growth factor 8a (gcFGF8a) has broad-spectrum and potent antibacterial activity through disrupting the cell membrane, indicating that FGF8 is an uncovered AMP. Further study revealed that gcFGF8a can accelerate skin wound healing through dual functions: inhibiting bacterial and activating of glycolysis. Mechanistically, gcFGF8a/FGFR4 signaling induces epithelial cell glycolytic programs for barrier remodeling through the mTORC1/HIF1α pathway. Interestingly, it is found that mouse FGF8b (mFGF8b), the homolog of gcFGF8a, also has antibacterial and skin wound repair activities, indicating that FGF8 is a functionally conserved molecule in vertebrates. To the knowledge, FGF8 is the only member of the FGF family with both antibacterial and wound repair functions at present, greatly enriching the understanding of this pivotal molecule. Furthermore, these findings highlighted the potential application of FGF8 as a skin wound repair drug.}, archive = {J_ADVS}, author = {Ya-Zhen Hu and Ting Wang and Chang-Song Wu and Jie Wang and Xue-Qing Han and Yong-An Zhang and Xu-Jie Zhang}, doi = {10.1002/advs.202500388}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e00388}, shortjournal = {Adv. Sci.}, title = {Novel antimicrobial protein fibroblast growth factor 8 accelerates skin wound healing via directly inhibiting bacteria and activating glycolysis}, volume = {12}, year = {2025}, }
• (2025). Orosomucoid 1 ameliorates temporomandibular joint osteoarthritis by maintaining cartilage homeostasis. ADVS, 12(36), e00028. (www)

  @article{ , abstract = {Temporomandibular joint osteoarthritis (TMJOA) is one of the most complex temporomandibular disorders. Cartilage matrix degradation results in the infiltration of nerves, blood vessels, and inflammatory cells, which disrupts chondrocyte function. Therapeutic strategies for TMJOA designed to maintain cartilage homeostasis remain largely unknown. Here, it is reported that orosomucoid 1 (ORM1) attenuated TMJOA progression by maintaining cartilage homeostasis. It is demonstrated that ORM1 is down-regulated in the synovial fluid of patients with TMJOA and condylar cartilage of unilateral anterior crossbite (UAC) rats. Administration of ORM1 protein significantly inhibited cartilage matrix degradation and alleviated TMJOA progression in UAC rats. At the mechanistic level, ORM1 binds to vimentin (VIM), a type III intermediate filament cytoskeletal protein, and inhibits the mitogen-activated protein kinase (MAPK) pathway, thereby significantly decreasing cartilage matrix degradation mediated through inhibiting the cartilage degradation markers matrix metalloproteinase 13 (MMP13) and MMP3, and maintaining cartilage homeostasis. Notably, inhibition of VIM in vivo also markedly improved TMJOA progression, including cartilage degradation and subchondral bone destruction. In conclusion, these findings demonstrate the important functions of ORM1 in maintaining cartilage homeostasis via suppressing VIM/MAPK/MMP signaling and suggest that ORM1 is a promising target for therapeutic intervention in TMJOA.}, archive = {J_ADVS}, author = {Dahe Zhang and Yuxin Zhang and Simo Xia and Lu Chen and Pei Shen and Chi Yang}, doi = {10.1002/advs.202500028}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e00028}, shortjournal = {Adv. Sci.}, title = {Orosomucoid 1 ameliorates temporomandibular joint osteoarthritis by maintaining cartilage homeostasis}, volume = {12}, year = {2025}, }
• (2025). MTCH2 deficiency promotes E2F4/TFRC-mediated ferroptosis and sensitizes colorectal cancer liver metastasis to sorafenib. ADVS, 12(36), e00019. (www)

  @article{ , abstract = {Ferroptosis is a specific type of lipid peroxide-mediated cell death which is crucial in tumor suppression. While the mitochondrial carrier homolog 2 (MTCH2) is implicated in lipid homeostasis and mitochondrial metabolism, its role in ferroptosis and colorectal cancer (CRC) remains uncharacterized. Here, MTCH2 is identified as a crucial regulator of ferroptosis in CRC progression. Clinically, high expression of MTCH2 in CRC tissues predicts poor prognosis. Functionally, loss of MTCH2 inhibits azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colorectal tumorigenesis in MTCH2 cKO mice and leads to accumulation of ferrous ion and enhances ferroptosis of CRC in vitro and in vivo. Mechanistically, MTCH2 deficiency promotes the proteasome-dependent ubiquitination of E2F4 and attenuates transcriptional inhibition of transferrin receptor (TFRC) by E2F4, ultimately facilitating TFRC-mediated ferroptosis in CRC cells. Moreover, MTCH2 depletion combined with sorafenib treatment synergistically triggers ferroptosis, suppresses liver metastasis, and effectively eradicates tumors in liver metastasis foci. Taken together, This study reveals the mechanism of MTCH2 deficiency-induced ferroptosis to inhibit the progression of CRC and supports a potential therapeutic strategy targeting the MTCH2/E2F4/TFRC signaling axis in CRC patients with liver metastasis.}, archive = {J_ADVS}, author = {Pu Xing and Jiangbo Chen and Hao Hao and Xiaowen Qiao and Xinying Yang and Kai Weng and Jie Chen and Lin Song and Tianqi Liu and Yifan Hou and Tongkun Song and Yumeng Ran and Bo Chen and Hong Yang and Wei Zhao and Zaozao Wang and Jiabo Di and Beihai Jiang and Xiangqian Su}, doi = {10.1002/advs.202500019}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {e00019}, shortjournal = {Adv. Sci.}, title = {MTCH2 deficiency promotes E2F4/TFRC-mediated ferroptosis and sensitizes colorectal cancer liver metastasis to sorafenib}, volume = {12}, year = {2025}, }
• (2025). STING COPII ER export trafficking and signaling primed by phosphorylation switches (Adv. sci. 36/2025). ADVS, 12(36), 71759. (www)

  @article{ , archive = {J_ADVS}, author = {Yanan Nan and Dongxiao Cui and Jiajian Guo and Xiaojing Ma and Jiaming Wang and Linyue Guo and Tianyu Li and Mingrui Yang and Guangrui Huang and Anlong Xu and Wenfu Ma}, doi = {10.1002/advs.71759}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {71759}, shortjournal = {Adv. Sci.}, title = {STING COPII ER export trafficking and signaling primed by phosphorylation switches (Adv. sci. 36/2025)}, volume = {12}, year = {2025}, }
• (2025). A phase separation-assisted pre-enrichment method for ultrasensitive respiratory virus detection (Adv. sci. 36/2025). ADVS, 12(36), 71748. (www)

  @article{ , archive = {J_ADVS}, author = {Yang Cao and Pui Ngan Lau and Alex W.H. Chin and Zhuolin He and Christina C. K. Au Yeung and Kehao Zeng and Haisong Lin and Leo L. M. Poon and Ho Cheung Shum}, doi = {10.1002/advs.71748}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {71748}, shortjournal = {Adv. Sci.}, title = {A phase separation-assisted pre-enrichment method for ultrasensitive respiratory virus detection (Adv. sci. 36/2025)}, volume = {12}, year = {2025}, }
• (2025). A network-driven framework for drug response precision prediction of acute myeloid leukemia (Adv. sci. 36/2025). ADVS, 12(36), 71747. (www)

  @article{ , archive = {J_ADVS}, author = {Yinyin Wang and Rui Liu and Yinnan Zhang and Xiang Luo and Chengzhuang Yu and Shentong Fang and Ninghua Tan and Jing Tang}, doi = {10.1002/advs.71747}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {71747}, shortjournal = {Adv. Sci.}, title = {A network-driven framework for drug response precision prediction of acute myeloid leukemia (Adv. sci. 36/2025)}, volume = {12}, year = {2025}, }
• (2025). Topological singularities and edge-state coupling enable robust on-chip slow light (Adv. sci. 36/2025). ADVS, 12(36), 71746. (www)

  @article{ , archive = {J_ADVS}, author = {Yuqian Wang and Shengyu Hu and Zhiwei Guo and Jie Jiang and Yaping Yang and Cuicui Lu and Hong Chen}, doi = {10.1002/advs.71746}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {71746}, shortjournal = {Adv. Sci.}, title = {Topological singularities and edge-state coupling enable robust on-chip slow light (Adv. sci. 36/2025)}, volume = {12}, year = {2025}, }
• (2025). A mitochondria-targeted nanozyme platform for multi-pathway tumor therapy via ferroptosis and cuproptosis regulation (Adv. sci. 36/2025). ADVS, 12(36), 71745. (www)

  @article{ , archive = {J_ADVS}, author = {Chenguang Liu and Lingxiao Guo and Yuying Cheng and Jingjie Gao and Hanling Pan and Jiayi Zhu and Danting Li and Liqing Jiao and Caiyun Fu}, doi = {10.1002/advs.71745}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {71745}, shortjournal = {Adv. Sci.}, title = {A mitochondria-targeted nanozyme platform for multi-pathway tumor therapy via ferroptosis and cuproptosis regulation (Adv. sci. 36/2025)}, volume = {12}, year = {2025}, }
• (2025). Novel antimicrobial protein fibroblast growth factor 8 accelerates skin wound healing via directly inhibiting bacteria and activating glycolysis (Adv. sci. 36/2025). ADVS, 12(36), 71744. (www)

  @article{ , archive = {J_ADVS}, author = {Ya-Zhen Hu and Ting Wang and Chang-Song Wu and Jie Wang and Xue-Qing Han and Yong-An Zhang and Xu-Jie Zhang}, doi = {10.1002/advs.71744}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {71744}, shortjournal = {Adv. Sci.}, title = {Novel antimicrobial protein fibroblast growth factor 8 accelerates skin wound healing via directly inhibiting bacteria and activating glycolysis (Adv. sci. 36/2025)}, volume = {12}, year = {2025}, }
• (2025). Alistipes senegalensis is critically involved in gut barrier repair mediated by panax ginseng neutral polysaccharides in aged mice (Adv. sci. 36/2025). ADVS, 12(36), 71743. (www)

  @article{ , archive = {J_ADVS}, author = {Dandan Wang and Hui Wang and Yingna Li and Jing Lu and Xiaolei Tang and Dan Yang and Manying Wang and Daqing Zhao and Fangbing Liu and Shuai Zhang and Liwei Sun}, doi = {10.1002/advs.71743}, journal = {Advanced Science}, month = {9}, number = {36}, pages = {71743}, shortjournal = {Adv. Sci.}, title = {Alistipes senegalensis is critically involved in gut barrier repair mediated by panax ginseng neutral polysaccharides in aged mice (Adv. sci. 36/2025)}, volume = {12}, year = {2025}, }
• (2025). GbSER02 interacts with GhVOZ1 to promote fiber elongation by modulating gibberellin synthesis in cotton. ADVS, 12(35), e17578. (www)

  @article{ , abstract = {The elongation period of cotton fiber development is crucial for ensuring cotton quality. However, the molecular mechanisms underlying fiber elongation remain unclear. This study reveals that SER02 _ A11 , which is preferentially expressed during the fiber elongation period, encodes serine protease inhibitors (serpins). A previously uncharacterized SNP 517th is localized in the gene's coding region between Gossypium barbadense and G. hirsutum , leading to the premature translation termination and low expression of GhSER02 in G. hirsutum . However, in G. barbadense , normal protein translation and high expression of GbSER02 are observed. Ectopic GbSER02 expression or site-directed GhSER02' mutagenesis (but not GhSER02 ) promotes trichome and root cell elongation in Arabidopsis , indicating that SNP 517th causes the dysfunction of GhSER02 . Overexpressing GbSER02 in G. hirsutum increases fiber length. GbSER02 interacts with the transcription factor GhVOZ1 (vascular one-zinc-finger protein) in the cytoplasm, alleviating the inhibitory effect of GhVOZ1 on GhGA3ox1 expression, thereby promoting gibberellin synthesis. Subsequently, the cell wall loosening-related genes GhXTH2 and GhEXPA1 are significantly upregulated whereas the flavonoid metabolism-related gene GhCHS1 is significantly downregulated, ultimately improving fiber length. Collectively, this study reveals the essential role of the GbSER02-GhVOZ1-GhGA3ox1 module in regulating fiber quality and provides novel insights into the mechanism of fiber development in cotton.}, archive = {J_ADVS}, author = {Hao Jia and Dongmei Zhang and Qishen Gu and Yanbin Li and Jing Li and Wannian Li and Zhengwen Sun and Huifeng Ke and Jun Yang and Liqiang Wu and Yan Zhang and Zhiying Ma and Xingfen Wang}, doi = {10.1002/advs.202417578}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e17578}, shortjournal = {Adv. Sci.}, title = {GbSER02 interacts with GhVOZ1 to promote fiber elongation by modulating gibberellin synthesis in cotton}, volume = {12}, year = {2025}, }
• (2025). Tumor extracellular vesicles aggravate mitochondrial damage in myocardial Ischemia/Reperfusion injury. ADVS, 12(35), e17493. (www)

  @article{ , abstract = {Cancer patients have a higher risk of all types of cardiovascular diseases (CVDs). Cardiologists are encountering a growing number of cancer patients with CVDs, and an increasing number of cancer patients undergoing percutaneous coronary intervention (PCI). The mechanistic link between cancer and CVDs remains elusive. Here, the meta-analysis shows the increased incidence ratio of all-cause mortality and cardiovascular (CV) mortality in patients undergoing PCI with cancer compared with non-cancer. We experimentally demonstrated that cancer aggravated mitochondrial dysfunction and myocardial ischemia/reperfusion (I/R) injury in two models of lung cancer in mice. Plasma extracellular vesicles (EVs) derived from cancer mice exacerbated cardiac I/R injury in vivo and in vitro, while inhibition of tumor EVs secretion by lipid-coated polyacrylic acid/calcium phosphate nanoparticles delivered a neutral sphingomyelinase inhibitor (GW4869) showed the opposite results. Lung-specific miR-485-3p sponges mediated by Adeno-associated virus 6 suppress cardiac damage and mitochondrial dysfunction in CC10-KRAS G12D mice post-I/R. Mechanistically, PPARGC1A/PGC-1α is post-transcriptionally repressed by miR-485-3p in cardiomyocytes, leading to the inhibition of mitochondrial complex I subunits and ATP synthesis. Taken together, our findings reveal for the first time that cancer can aggravate cardiac injury and mitochondrial dysfunction by releasing miR-485-3p-enriched extracellular vesicles derived from cancer cells.}, archive = {J_ADVS}, author = {Zhongting Mei and Qian Liu and Guoxin Liu and Manjie Zhang and Jiaxin Fang and Xuting He and Xueqi He and Zhengwei Qin and Ronghua Liu and Chuang Liu and Hongyu Ji and Yuechao Dong and Ye Yuan and Baofeng Yang and Weijie Du}, doi = {10.1002/advs.202417493}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e17493}, shortjournal = {Adv. Sci.}, title = {Tumor extracellular vesicles aggravate mitochondrial damage in myocardial Ischemia/Reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Topology augmented with geometry in the assembly of structural databases: Kagome intermetallics. ADVS, 12(35), e17041. (www)

  @article{ , abstract = {Creation of well-curated databases tailored to specific structural motifs can underpin and drive materials discovery, as the properties of materials are governed by composition and structure. The role of such motifs in directing the intricate interplay between structure and properties is exemplified by intermetallic compounds with structures that contain kagome layers that exhibit a variety of exotic physical states. Two prevailing approaches have previously been applied to identify such materials: evaluation of structural topology or geometry assessment, however, both present limitations if deployed individually. We augment topological screening with geometrical filtering to allow versatile control over the identification of kagome layers. Applying this approach with minimal further constraints labels over 9000 kagome-containing intermetallics which are assigned to four structural classes, revealing connections between symmetry, composition, direct space structure, and flatband electronic structures in reciprocal space. A machine learning model is used to predict new element combinations that favour the formation of kagome layers. Several highly-ranked phase fields correspond to known kagome-containing materials that were absent from the training dataset, demonstrating that the workflow can identify chemistries affording kagome layers. This motivates the extension of the approach beyond kagome to other property-conferring motifs, such as honeycomb, square planar or triangular plane nets.}, archive = {J_ADVS}, author = {Nataliya L. Gulay and Dongsheng Wen and Joshua E. Griffiths and Judith Clymo and Luke M. Daniels and Jonathan Alaria and Matthew S. Dyer and John B. Claridge and Matthew J. Rosseinsky}, doi = {10.1002/advs.202417041}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e17041}, shortjournal = {Adv. Sci.}, title = {Topology augmented with geometry in the assembly of structural databases: Kagome intermetallics}, volume = {12}, year = {2025}, }
• (2025). LEDGF binds H3R17me2a promoting de novo nucleotide biosynthesis in SETD2 mutant clear cell renal cell carcinoma. ADVS, 12(35), e16809. (www)

  @article{ , abstract = {Previous studies have identified that lens epithelium-derived growth factor (LEDGF) interacts with SETD2-dependent histone H3 trimethylated at lysine 36 (H3K36me3) to mediate transcriptional elongation. However, the original LEDGF recognition H3K36me3 epigenetic regulatory axis no longer exists in SETD2 mutant clear cell renal cell carcinoma (ccRCC) patients, and a new transcription system needs to be discovered. In this study, the authors demonstrated the novel interaction between LEDGF and H3R17me2a. In detail, Asn38 and Asp57 of LEDGF Proline-Tryptophan-Tryptophan-Proline (PWWP) domain are the key binding sites validated by peptide pull-down assays. Subsequently, a series of in vitro and in vivo experiments showed that PPAT , PAICS , GART , ADSL , and ADSS2 are key target genes. Collectively, LEDGF binds H3R17me2a to regulate purine nucleotide metabolism in SETD2 mutant ccRCC cells, promoting tumor proliferation, and may be an effective therapeutic target.}, archive = {J_ADVS}, author = {Yuwei Zhang and Yuhua Zhou and Yuezhou Zhang and Jing Lv and Yang Shen and Dong Zhang and Bo Liu and Wei Zhao and Junyi Ju and Qingyi Zhu and Ke Wang and Ninghan Feng}, doi = {10.1002/advs.202416809}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e16809}, shortjournal = {Adv. Sci.}, title = {LEDGF binds H3R17me2a promoting de novo nucleotide biosynthesis in SETD2 mutant clear cell renal cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Maximizing efficacy of cancer nanovaccines and immune cells landscape in responders and non-responders to immunotherapy. ADVS, 12(35), e16756. (www)

  @article{ , abstract = {Adjuvants, formulations, and processing of tumor antigens (collection, lysis, purification, and oxidation) can affect the therapeutic efficacy of cancer vaccines. To maximize their efficacy, adjuvants and their combinations are investigated to prepare vaccines with whole tumor antigens. By comparing different nano/micro-vaccines, ≤ 400 nm and 2.5 µm, respectively, are identified as their optimal sizes. When used alone, the optimal cancer vaccine cures all or most tumor-bearing mice with melanoma, lung cancer, pancreatic cancer, and melanoma lung metastasis. The landscape of immune cells in the blood, splenocytes, and draining lymph nodes of vaccine-treated mice is systematically investigated using single-cell sequencing. The diversity of CD8 + T cell receptors (TCR), CD4 + TCR, and B cell receptors (BCR) in cured mice is higher than that in uncured mice. By comparing 21 samples, several biomarkers, including KLRG1, S100A4, S1PR5, IL2Ra, and IKZF2, were identified to distinguish responders and non-responders to immunotherapy. Moreover, S100A4, S1PR5 and KLRG1, are biomarkers of therapeutic efficacy in mouse cancer models and patients with cancer. Hence, this study presents an optimized cancer vaccine that cures most tumor-bearing mouse models and the landscape of immune cells in non-responders and responders to immunotherapy. The results of this study will help to develop better cancer vaccines.}, archive = {J_ADVS}, author = {Xiangxiang Xu and Lu Diao and Jin Wang and Ao Zhu and Xianlan Chen and Yan Zheng and Yuhan Liu and Kang Hu and Jiashan Zhu and Cheng Ding and Chang Li and Yunzhi Pan and Jun Zhao and Mi Liu}, doi = {10.1002/advs.202416756}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e16756}, shortjournal = {Adv. Sci.}, title = {Maximizing efficacy of cancer nanovaccines and immune cells landscape in responders and non-responders to immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Choroid plexus Fibroblast–ILC2 niche promotes adult hippocampal neurogenesis after traumatic brain injury. ADVS, 12(35), e15984. (www)

  @article{ , abstract = {Mounting evidence has indicated that immune signals originating from the brain's border tissues will exert a profound influence on brain parenchyma neural cells. However,  the structural component alterations and immune cell infiltration characteristics of choroid plexus (ChP) following traumatic brain injury (TBI) remain incompletely understood. Here, using single-cell RNA sequencing and histological analysis, the accumulation of group 2 innate lymphoid cell (ILC2) in the ChP stroma post-TBI is identified. Intracerebroventricular adoptive transfer of ILC2 is further indicated to exhibit a tendency to colonize the ChP and significantly alleviate pathogenic immune infiltration during the acute phase of TBI, as well as maintain hippocampal integrity during the chronic phase. Sensory-motor function and memory impairments in TBI mice are also improved under ILC2 treatment. Mechanistically, ILC2 is induced by ChP fibroblasts derived IL33 and anchored to stroma fibroblasts via the VCAM-1/Integrin α4β7 pathway. Furthermore, single-nucleus RNA sequencing of the hippocampus reveals that ILC2-derived AREG promotes the initiation of neurogenesis by interacting with EGFR on early-stage neurogenic cells. Overall, these findings highlight that ChP-resident ILC2, through optimizing the immune microenvironment and promoting neurogenesis after TBI, may represent a potential therapeutic strategy.}, archive = {J_ADVS}, author = {Shiqi Gao and Xiaoming Guo and Sixuan Tian and Huaping Huang and Caidi Ying and Junjie Wang and Jiahao Zhang and Jun Lin and Anwen Shao and Jingyu Wang and Yuan Hong}, doi = {10.1002/advs.202415984}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e15984}, shortjournal = {Adv. Sci.}, title = {Choroid plexus Fibroblast–ILC2 niche promotes adult hippocampal neurogenesis after traumatic brain injury}, volume = {12}, year = {2025}, }
• (2025). C(sp3)─S bond formation via the synergy of oxidative with reductive photocatalysts through photoredox and dual hydrogen atom transfer processes. ADVS, 12(35), e15936. (www)

  @article{ , abstract = {A primary objective of organic synthesis is to establish a catalytic methodology that is mild, straightforward, and economically efficient. Thioesters are widely employed in the realms of physiology, pharmacology, and agriculture. It is imperative to continuously expand the range of sulfur-containing precursors to keep pace with the cutting-edge advancements in the field of organic sulfur chemistry. This research has uncovered that polysulfide anions (K 2 S x ), which serve as reducing catalysts, can also effectively act as sulfur reagents, providing the formation of C( sp 3 )–S bonds through a photoredox catalysis with an oxidative photocatalyst tetrabutylammonium decatungstate (TBADT) and dual hydrogen atom transfer (DHAT) process. In a pioneering study, a combinatorial strategy of an oxidative photocatalyst TBADT is presented with a reductive photocatalyst K 2 S x , enabled a photo-induced three-component coupling reaction of simple aldehydes with alkanes containing C (sp 3 )─H and polysulfide anions. A numbers of thioester derivatives are successfully obtained in good yields, while a by-product H 2 S is captured and identified by gas chromatography analysis. Concurrently, density functional theory (DFT) calculations provided the theoretical support of the reaction mechanism.}, archive = {J_ADVS}, author = {Chao Zhou and Qianli Liang and Xinyi Zhu and Xue Zhang and Limei Liu and Yicheng Zhang and Jie Liu and Xiaoyu Xie and Lei Wang}, doi = {10.1002/advs.202415936}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e15936}, shortjournal = {Adv. Sci.}, title = {C(sp3)─S bond formation via the synergy of oxidative with reductive photocatalysts through photoredox and dual hydrogen atom transfer processes}, volume = {12}, year = {2025}, }
• (2025). An injectable BMP-2-releasing porous hydrogel regulating the paracrine effects of ADSCs promotes tendon-to-bone healing in rotator cuff repair. ADVS, 12(35), e15923. (www)

  @article{ , abstract = {Rotator cuff tears often require surgical reconstruction; however, outcomes remain suboptimal, primarily because of the challenges in fully restoring the tendon–bone interface (TBI). The normal fibrocartilaginous transition zone is often replaced by fibrous scar tissue, thereby increasing the risk of retears. A porous hyaluronic acid methacrylate hydrogel is developed to encapsulate adipose-derived stem cells (ADSCs) and bone morphogenetic protein-2 (BMP-2). Gelatin microspheres served as porogens to create micropores within the hyaluronic acid methacrylate hydrogel (HMs), and hollow gelatin methacryloyl hydrogel microspheres are used to encapsulate BMP-2 (GMBs). In vitro experiments confirm substantial proliferation and homing of ADSCs within the porous hydrogel system. When the ADSCs-loaded composite hydrogel (HMs/MBs/ADSCs) is applied to a rat rotator cuff injury model, it effectively reconstructs the fibrocartilage transition zone and promotes TBI healing. Transcriptome sequencing is performed to elucidate the mechanisms underlying BMP-2-induced fibrocartilage reconstruction. Furthermore, integrated in vitro sequencing reveals that HMs/MBs/ADSCs modulated the tissue microenvironment to enhance tissue regeneration, primarily through BMP-2′s regulation of the paracrine effects of ADSCs. This study explores the comprehensive pathway through which HMs/MBs/ADSCs enhance tissue regeneration, emphasizing the synergistic effects of BMP-2 and ADSCs, and offers novel insights into the mechanisms underlying TBI healing.}, archive = {J_ADVS}, author = {Meijuan Yuan and Xiaomei Dai and Yuxia Yang and Shuai Liu and Ziyi Xu and Liang Wang and Junli Shi and Wenkang Liu and Jian Yang and Dianwei Liu and Hang Yao and Wenyong Fei}, doi = {10.1002/advs.202415923}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e15923}, shortjournal = {Adv. Sci.}, title = {An injectable BMP-2-releasing porous hydrogel regulating the paracrine effects of ADSCs promotes tendon-to-bone healing in rotator cuff repair}, volume = {12}, year = {2025}, }
• (2025). Correction to “Engineering decavalent, sperm-binding laminin-IgG hybrid antibodies for potent non-hormonal contraception”. ADVS, 12(35), e14968. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202514968}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e14968}, shortjournal = {Adv. Sci.}, title = {Correction to “Engineering decavalent, sperm-binding laminin-IgG hybrid antibodies for potent non-hormonal contraception”}, volume = {12}, year = {2025}, }
• (2025). An antagonism between ethylene signaling and DNA methylation orchestrates the progression of leaf senescence in non-heading chinese cabbage. ADVS, 12(35), e14954. (www)

  @article{ , abstract = {Leaf senescence significantly impacts both the yield and quality of non-heading Chinese cabbage (NHCC). Despite its importance, the molecular mechanisms underlying the initiation and progression of leaf senescence in NHCC remain poorly understood. Here, transcriptome changes are first profiled, and found that ethylene (ET) and salicylic acid (SA) signaling pathways are activated during leaf senescence. Further mining of ET, SA, and DNA methylation pathway genes identified that EIN3A and CMT2 are induced and repressed, respectively, during leaf senescence. A whole-genome bisulfite sequencing (WGBS) analysis revealed a global reduction of DNA methylation during leaf senescence, with the most dramatic decline occurring in the 1 kb regions upstream of transcription start sites (TSS) and downstream of transcription end sites (TES). Knocking down of EIN3A and CMT2 via virus-induced gene silencing (VIGS) demonstrated that EIN3A is crucial for ET- and age-triggered leaf senescence, while CMT2 plays an inhibitory role. It further showed that EIN3A directly represses the expression of CMT2 to release its “braking” role on senescence-associated genes ( SAGs ) expression. Thus, the study uncovers a pivotal antagonistic interaction between ET signaling and DNA methylation, which may be involved in setting the pace for the progression of leaf senescence in NHCC.}, archive = {J_ADVS}, author = {Dingyu Zhang and Yong Luo and Han Wang and Xiaofeng Li and Liming Miao and Lu Gao and Haibo Hao and Xinman Wang and Benke Kuai and Hongfang Zhu and Guodong Ren}, doi = {10.1002/advs.202414954}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e14954}, shortjournal = {Adv. Sci.}, title = {An antagonism between ethylene signaling and DNA methylation orchestrates the progression of leaf senescence in non-heading chinese cabbage}, volume = {12}, year = {2025}, }
• (2025). Correction to “Pyramid textured photonic films with high-refractive index fillers for efficient radiative cooling”. ADVS, 12(35), e14484. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202514484}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e14484}, shortjournal = {Adv. Sci.}, title = {Correction to “Pyramid textured photonic films with high-refractive index fillers for efficient radiative cooling”}, volume = {12}, year = {2025}, }
• (2025). Human bone-derived endothelial cells mediate bone regeneration via distinct expression of KIT ligand. ADVS, 12(35), e14194. (www)

  @article{ , abstract = {Effective bone regeneration remains a significant challenge in surgical practice, particularly due to the limitations associated with autologous bone grafting, such as donor site morbidity and limited bone availability. This study investigated the potential of human bone-derived endothelial cells (b-ECs) in mediating bone regeneration, especially in conjunction with bone marrow-derived mesenchymal stem cells (bm-MSCs). It is demonstrated that b-ECs retain unique osteoinductive properties post-isolation, crucial for promoting bone formation in vivo. Utilizing ectopic and orthotopic xenograft models in immunodeficient mice, these findings revealed that the synergistic interaction of b-ECs and bm-MSCs induced rapid and substantial bone formation, highlighting the therapeutic potential of b-ECs in bone repair strategies. The distinct expression of KIT ligand (KITLG) in b-ECs emerged as a key factor in these processes. KITLG expression by b-ECs facilitated the recruitment of c-Kit+/CD34+ hematopoietic progenitor cells to the osteovascular niche, leading to robust osteogenic differentiation of bm-MSCs, a process regulated by Notch signaling. Moreover, inducing KITLG expression in non-bone-derived endothelial cells conferred similar osteoinductive capabilities. These findings not only enhance the understanding of the intricate interplay between vascular and bone tissues but also open avenues for developing innovative cell-based approaches for bone regeneration therapy.}, archive = {J_ADVS}, author = {Xiang Li and Hwan D. Kim and Allen C. Luo and Liyan Gong and Yonglin Zhu and Chin Nien Lee and Xuechong Hong and Christopher L. Sudduth and Michal Ad and Young-Hyeon An and Mihn Jeong Park and Do-Gyoon Kim and Arin K. Greene and Bonnie L. Padwa and Nathaniel S. Hwang and Ruei-Zeng Lin and Juan M. Melero-Martin}, doi = {10.1002/advs.202414194}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e14194}, shortjournal = {Adv. Sci.}, title = {Human bone-derived endothelial cells mediate bone regeneration via distinct expression of KIT ligand}, volume = {12}, year = {2025}, }
• (2025). Enhanced media optimize bovine myogenesis in 2D and 3D models for cultivated meat applications. ADVS, 12(35), e13998. (www)

  @article{ , abstract = {Livestock farming and conventional meat production pose significant environmental, health, and animal welfare challenges. In seeking sustainable alternative solutions, cultivated meat technology typically utilizes differentiation of myogenic progenitor cells (MPCs) into muscle cells for in vitro meat production. However, understanding the molecular determinants governing MPC differentiation into muscle cells, and the potential enhancement of this process through modulation of signaling pathways, remains limited. Herein, we characterized the molecular landscape associated with bovine MPC differentiation in vitro by employing multiomics, and explored its augmentation by small molecules, together leading to identification of media that enhanced myogenic differentiation compared with conventional methods in both 2D cultures and tissue-engineered 3D skeletal muscle constructs. Through bulk and single-cell transcriptomics and proteomics, we compared conventional and enhanced differentiation media, demonstrating that the enhanced media gave rise to unique progenitor-like cell populations, while simultaneously promoting differentiation into myocytes and contractile myotubes expressing a wide array of myogenic markers that more closely resemble bovine muscle cells in vivo. The improved method for promoting myogenic differentiation in 2D and 3D formats, together with the corresponding molecular roadmap, may prove valuable for cultivated meat applications.}, archive = {J_ADVS}, author = {Christine L. Trautmann and Adhideb Ghosh and Ali Kerem Kalkan and Falko Noé and Ori Bar-Nur}, doi = {10.1002/advs.202413998}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e13998}, shortjournal = {Adv. Sci.}, title = {Enhanced media optimize bovine myogenesis in 2D and 3D models for cultivated meat applications}, volume = {12}, year = {2025}, }
• (2025). Compressed cells facilitate adhesion through glycocalyx. ADVS, 12(35), e13586. (www)

  @article{ , abstract = {Exposed to mechanical confinement, mammalian cells can establish remarkable unspecific adhesion, which is independent of integrins. How cells facilitate such adhesion remains unclear. Here, it is investigated how mammalian cells exposed to compression initiate unspecific and integrin-mediated adhesion. It is observed that with increasing compression, cells increase adhesion to collagen I or fibronectin and strengthen adhesion faster. Under low and medium compression, cells minimally increase unspecific adhesion to substrates that lack specific binding sites for cell surface receptors, such as integrins. However, under high compression, mammalian cells switch to a strong unspecific adhesion state, which significantly contributes to cell-extracellular matrix (ECM) adhesion. Thereby cells use the glycocalyx to directly facilitate strong unspecific adhesion and to enhance early integrin-mediated adhesion. The mechanistic insight of how cells unspecifically adhere to substrates under confinement opens avenues to better understand cell adhesion in development, homeostasis, disease, and in a wide range of biotechnological and medical applications in which cells are exposed to mechanical confinement.}, archive = {J_ADVS}, author = {Xiaole Wang and Jonne Helenius and Daniel J. Müller and Nico Strohmeyer}, doi = {10.1002/advs.202413586}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e13586}, shortjournal = {Adv. Sci.}, title = {Compressed cells facilitate adhesion through glycocalyx}, volume = {12}, year = {2025}, }
• (2025). Targeting cystine metabolism in the lung cancer environment enhances the efficacy of immune checkpoint inhibition. ADVS, 12(35), e13084. (www)

  @article{ , abstract = {Immunotherapy with Immune Checkpoint Inhibitors (ICIs) has shown promising therapeutic effects in the treatment of lung cancer, the overall efficacy of PD-1/PD-L1 inhibitors is only 20%-30%. Thus, more effective combination therapies are needed. This study finds that cystine and cysteine levels in tumor tissues of lung cancer patients are significantly higher than adjacent non-tumor tissues. Cystine deficiency polarizes macrophages toward an M1 phenotype, secreting more TNF-α, CXCL9, and CXCL10. However, using a cystine-free diet marginally reduces the development of lung cancer in vivo. A cystine-free diet slightly reduces lung cancer progression in vivo. Further studies show that cystine deprivation or erastin-mediated transport inhibition increased PD-L1 expression in macrophages both in vitro and in vivo. Combining a cystine-free diet or IKE injection with PD-L1 antibody treatment significantly inhibited subcutaneous tumor growth in mice. Mechanistic studies indicat that cystine deficiency-induced GSH depletion activates NF-κB in macrophages by reducing its glutathionylation. This effect can be reversed by replenishing GSH or using an NF-κB inhibitor. At the same time, lung cancer patients with better responses to immunotherapy are found to have lower serum GSH levels. These findings suggest that targeting cystine metabolism combined with PD-L1 inhibition is a promising therapeutic strategy.}, archive = {J_ADVS}, author = {Yun Xu and Shumin Li and Jiaji Wu and Shumin Xu and Mo Shen and Chenyang Wang and Lundqvist Andreas and Jianghao Yu and Zhiyong Xu and Yueli Shi and Nana Liu and Yunke Yang and Jiangnan Zhao and Ying Yang and Pingli Wang and Peng Yi and Jin Cheng and Junhui Sun and Mengshu Li and Peng Xiao and Kai Wang}, doi = {10.1002/advs.202413084}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e13084}, shortjournal = {Adv. Sci.}, title = {Targeting cystine metabolism in the lung cancer environment enhances the efficacy of immune checkpoint inhibition}, volume = {12}, year = {2025}, }
• (2025). Real-time detection of hot electrons during chemical reactions with catalytic nanodevices. ADVS, 12(35), e12017. (www)

  @article{ , abstract = {Hot electrons generated via non-adiabatic electronic excitations during catalytic reactions offer new insights into charge transfer dynamics at catalytic interfaces. Recent advancements in catalytic nanodevices, particularly metal–semiconductor Schottky nanodiodes, have enabled real-time detection of hot electrons via chemicurrent measurements. Initial studies focused on thin-film-based nanodiodes under vacuum conditions, but more advanced studies conducted under ambient-pressure environments reveal a direct correlation between hot electron excitation and catalytic performance. Furthermore, integrating nanocatalysts into nanodiodes has narrowed the gap between model systems and practical catalysts, demonstrating hot electron excitation in nanoparticle-based systems. This review highlights key experimental developments in hot electron research, discussing strategies to enhance detection efficiency and potential applications in catalysis. The ability to manipulate electron flow at catalytic interfaces suggests future opportunities for electronically tunable catalysis, offering a pathway toward energy-efficient and selective reaction control.}, archive = {J_ADVS}, author = {Yeji Yoon and Si Woo Lee}, doi = {10.1002/advs.202512017}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e12017}, shortjournal = {Adv. Sci.}, title = {Real-time detection of hot electrons during chemical reactions with catalytic nanodevices}, volume = {12}, year = {2025}, }
• (2025). Succinate dehydrogenase subunit a (SDHA) mediated microglia extracellular traps formation participating in cerebral ischemic reperfusion injury. ADVS, 12(35), e11873. (www)

  @article{ , abstract = {Ischemia reperfusion (I/R) injury associated with recanalization therapy in acute ischemic stroke (AIS) exacerbates the initial brain damage. However, it remains a clinical challenge due to limited understanding of the underlying mechanisms of I/R injury. This study aims to investigate the mechanism of succinate dehydrogenase (SDH)-mediated succinate oxidation in microglia extracellular traps (MiETs) formation and neuronal injury after cerebra I/R injury. The results show that microglia are the main cell type producing extracellular traps (ETs) at 24 h at cerebral parenchyma after cerebral I/R. Additionally, oxygen glucose deprivation/re-oxygenation (OGD/R) could induce MiETs formation and increased level of mitochondrial reactive oxygen species (mtROS). Microglia switches toward glycolysis with enhanced SDH activity and upregulated expression of SDH subunit A (SDHA) during MiETosis. Dimethyl malonate (DMM), a competitive SDH inhibitor, could reduce MiETosis by inhibiting succinate oxidation and mtROS production during reperfusion. Furthermore, DMM is found to alleviate neuronal injury after OGD/R exposure and neurological behavior disorders after cerebral I/R, and the effect is similar to MiETosis inhibitor BB-Cl amidine. These findings reveal a novel functional state of microglia and the role of succinate oxidation in MiETosis after cerebral I/R and provide a novel potential target for the treatment of AIS.}, archive = {J_ADVS}, author = {Lili Zhao and Tao Li and Meijuan Dang and Ye Li and Jialiang Lu and Ziwei Lu and Zhiyang Chen and Qiao Huang and Yujie Chen and Yang Yang and Yuxuan Feng and Xiaoya Wang and Yating Jian and Heying Wang and Yingying Guo and Lei Zhang and Yu Jiang and Songhua Fan and Shengxi Wu and Hong Fan and Fang Kuang and Guilian Zhang}, doi = {10.1002/advs.202411873}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e11873}, shortjournal = {Adv. Sci.}, title = {Succinate dehydrogenase subunit a (SDHA) mediated microglia extracellular traps formation participating in cerebral ischemic reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Correction to “An avascular niche created by axitinib-loaded PCL/Collagen nanofibrous membrane stabilized subcutaneous chondrogenesis of mesenchymal stromal cells”. ADVS, 12(35), e11638. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202511638}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e11638}, shortjournal = {Adv. Sci.}, title = {Correction to “An avascular niche created by axitinib-loaded PCL/Collagen nanofibrous membrane stabilized subcutaneous chondrogenesis of mesenchymal stromal cells”}, volume = {12}, year = {2025}, }
• (2025). Low-frequency microwave absorption composites. ADVS, 12(35), e11580. (www)

  @article{ , abstract = {Electromagnetic wave devices and components operating in the low-frequency band of 1–8 GHz (L, S, and C bands) are widely applied in wireless data communication systems, satellite radar, and other fields. However, traditional low-frequency microwave absorption materials (MAMs) suffer from issues such as large thickness, heavy weight, difficult impedance matching, insufficient low-frequency microwave loss, and poor environmental stability, severely limiting use and development. In recent years, researchers construct composite systems combining various types of loss, coupled with component adjustments and structural design strategies, significantly improving the impedance matching and multiple loss synergy effects for low-frequency MAMs. Based on the above, this review briefly introduces the basic principle of microwave absorption and the influence factors of low-frequency microwave absorption performance, and systematically reviews the recent research progress of carbon-based composites, magnetics-based composites, polymer-based composites, ceramic-based composites, and multiphase hybrid composites. Additionally, the intrinsic relationship and mechanisms are discussed in detail between the micro-structure and macro-performance of different composites. Furthermore, the key scientific and technical bottleneck problems that need to be addressed in the design and preparation of low-frequency MAMs are identified. It is expected to provide theoretical guidance for the controlled preparation and performance regulation of low-frequency microwave absorption composites.}, archive = {J_ADVS}, author = {Mukun He and Kaiyu Zhang and Hua Qiu and Hua Guo and Xiangcheng Li and Yongqiang Guo and Yali Zhang and Junwei Gu}, doi = {10.1002/advs.202511580}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e11580}, shortjournal = {Adv. Sci.}, title = {Low-frequency microwave absorption composites}, volume = {12}, year = {2025}, }
• (2025). METTL14-mediated M6A modification of LINC01094 induces glucose metabolic reprogramming in breast cancer by recruiting the PKM2/JMJD5 complex. ADVS, 12(35), e10386. (www)

  @article{ , abstract = {Tumor cells reprogram their energy metabolism patterns to meet the needs of rapid growth and metastasis. The underlying mechanisms of long noncoding RNAs (lncRNAs) in glucose metabolism remodeling in breast cancer (BC) are still not well understood. Herein, the expression of a tumorigenic lncRNA, LINC01094 are demonstrated that, is significantly increased in BC tissues and is associated with poorer patient survival. METTL14-mediated m 6 A modification stabilized LINC01094 by recruiting the reader protein IGF2BP2, which contributed to the upregulation of LINC01094 expression in BC. Gain- and loss-of-function assays validated that LINC01094 triggered a switch in glucose metabolism from mitochondrial respiration to glycolysis, promoting BC progression both in vitro and in vivo. LINC01094 promoted the dimeric assembly and nuclear translocation of PKM2 by acting as a “molecular scaffold” for the PKM2/JMJD5 complex. This, in turn, facilitated energy metabolic reprogramming and cell proliferation induced by HIF1-α/β-catenin. Furthermore, the therapeutic potential of LINC01094 is evaluated through the administration of the PKM2 activator TEPP-46 in mouse xenografts. These findings highlight the critical roles of LINC01094 in cellular glucose metabolism and tumorigenesis in BC, suggesting that it is a potential therapeutic target.}, archive = {J_ADVS}, author = {Mengqi Wang and Zhaoxin Gao and Ruinan Zhao and Pan Zhou and Jingxi Chen and Hui Zhang and Yawen Wang and Wenjie Zhu and Peng Gao}, doi = {10.1002/advs.202410386}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e10386}, shortjournal = {Adv. Sci.}, title = {METTL14-mediated M6A modification of LINC01094 induces glucose metabolic reprogramming in breast cancer by recruiting the PKM2/JMJD5 complex}, volume = {12}, year = {2025}, }
• (2025). Artificial intelligence-driven proteomics identifies plasma protein signatures for diagnosis and stratification of behçet's disease. ADVS, 12(35), e10061. (www)

  @article{ , abstract = {The diagnosis of Behçet’s disease (BD) predominantly relies on clinical symptoms, indicating an urgent for identifying potential biomarkers for early diagnosis and disease stratification. We employed an in-depth proteomics platform based on data-independent acquisition mass spectrometry (DIA-MS) and customizable antibody microarray technology, combined with machine learning methods. By analyzing the proteomic data in the training cohort, we trained an XGBoost machine learning model, and validated the model in an independent cohort. The model displayed a favorable performance in BD diagnosis and stratification. In the training set, the area under the curve (AUC) of the diagnostic model was 0.984 with an accuracy of 0.935. In the validation set, the AUC was 0.967 with an accuracy of 0.871. The AUCs for differentiating different severity BD groups ranged from 0.897 to 0.986 in the training set, and from 0.718 to 0.960 in the validation set. Functional analysis indicated that processes such as defense response, protein activation cascade, and complement activation were related to disease severity. Complement C4B was crucial in the protein-protein interaction network. This study is the first to construct an artificial intelligence-based BD diagnosis and stratification model, providing potential biomarkers and new strategies for precise diagnosis and treatment of BD. The diagnosis of BD predominantly relies on clinical symptoms, indicating an urgent for identifying potential biomarkers for early diagnosis and disease stratification. We employed an in-depth proteomics platform based on data-independent acquisition mass spectrometry (DIA-MS) and customizable antibody microarray technology, combined with machine learning methods. By analyzing the proteomic data in the training cohort, we trained an XGBoost machine learning model, and validated the model in an independent cohort. The model displayed a favorable performance in BD diagnosis and stratification. In the training set, the area under the curve (AUC) of the diagnostic model was 0.984 with an accuracy of 0.935. In the validation set, the AUC was 0.967 with an accuracy of 0.871. The AUCs for differentiating different severity BD groups ranged from 0.897 to 0.986 in the training set, and from 0.718 to 0.960 in the validation set. Functional analysis indicated that processes such as defense response, protein activation cascade, and complement activation were related to disease severity. Complement C4B was crucial in the protein-protein interaction network. This study is the first to construct an artificial intelligence-based BD diagnosis and stratification model, providing potential biomarkers and new strategies for precise diagnosis and treatment of BD.}, archive = {J_ADVS}, author = {Linlin Cheng and Mansheng Li and Zhou Bai and Xiaobo Yu and Wenjie Zheng and Yongzhe Li and Yudong Liu}, doi = {10.1002/advs.202510061}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e10061}, shortjournal = {Adv. Sci.}, title = {Artificial intelligence-driven proteomics identifies plasma protein signatures for diagnosis and stratification of behçet's disease}, volume = {12}, year = {2025}, }
• (2025). Enabling high-performance electrode materials for potassium-ion batteries: Ionic transport, size and Electro–Chemo–Mechanical effects. ADVS, 12(35), e09543. (www)

  @article{ , abstract = {Potassium-ion batteries, which possess unique advantages such as lower K + /K redox potential compared to sodium and superior interfacial charge transfer dynamics, demonstrate considerable viability for grid-level energy storage deployment. However, the development of potassium electrodes remains constrained by sluggish solid-state diffusion of K + within electrodes and progressive structural failure by the large volume variation during (de)intercalation, which requires a thorough understanding ionic transport, size effects, and electro–chemo–mechanical properties of electrodes, to achieve rational design and controlled synthesis. This review initiated with a comprehensive evaluation of potassium-based batteries from five aspects: energy density, power density, cycle life, safety, and cost. Afterward, a systematical examination for key aspects of potassium electrodes from a unique perspective is provided, starting with the fundamental scientific issues of transport properties (key features, anomalous cases, regulation, measurement and prediction) and size effects (kinetics, thermodynamics, potassium storage and transport mechanisms), while further discussing the specific electro–chemo–mechanical properties (composition–structure regulation, nanostructure and interface engineering). Additionally, this review highlights the construction of high-entropy electrodes and the pivotal role of machine learning in developing potassium electrodes. This review aims to provide critical guidance for future basic research and industrial applications of potassium electrode materials.}, archive = {J_ADVS}, author = {Changbao Zhu and Yanpeng Fu and Yong Yang}, doi = {10.1002/advs.202509543}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e09543}, shortjournal = {Adv. Sci.}, title = {Enabling high-performance electrode materials for potassium-ion batteries: Ionic transport, size and Electro–Chemo–Mechanical effects}, volume = {12}, year = {2025}, }
• (2025). Advances in stabilizing spinel cobalt oxide-based catalysts for acidic oxygen evolution reaction. ADVS, 12(35), e09415. (www)

  @article{ , abstract = {Oxygen evolution reaction (OER) is pivotal to sustainable energy storage and conversion technologies. Yet, its sluggish kinetics in acidic media and reliance on expensive noble metal catalysts limit its efficiency in these applications. Spinel cobalt(II, III) oxide (Co 3 O 4 )-based catalysts are cost-effective alternatives with high theoretical catalytic activity. However, their practical deployment is hindered by their poor stability in acidic electrolytes. This review critically examines recent advances in enhancing the stability of spinel Co 3 O 4 -based catalysts for acidic OER. The fundamental reaction mechanisms of acidic OER are first analyzed to illustrate how different catalyst design strategies can be used to improve their stability. Next, five key catalyst design strategies reported in recent studies are summarized: 1) constructing protective surface layers, 2) modulating reaction pathways, 3) controlling cobalt redox dynamics, 4) tuning cobalt-oxygen covalency, and 5) stabilizing lattice oxygen. Further, recent research progress in understanding the structure-activity-stability relationship of spinel Co 3 O 4 -based catalysts is summarized, with a focus on identifying their catalytically active sites, tracking surface reconstruction, and elucidating degradation mechanisms. This review ends with a discussion of future research directions for addressing key challenges in realizing durable, high-performance Co 3 O 4 -based catalysts for acidic OER applications.}, archive = {J_ADVS}, author = {Chengli Rong and Qian Sun and Jiexin Zhu and Hamidreza Arandiyan and Zongping Shao and Yuan Wang and Yuan Chen}, doi = {10.1002/advs.202509415}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e09415}, shortjournal = {Adv. Sci.}, title = {Advances in stabilizing spinel cobalt oxide-based catalysts for acidic oxygen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). Topoisomerase i inhibition in ETV4-overexpressed non-small cell lung cancer promotes replication and transcription mediated R-loop accumulation and DNA damage. ADVS, 12(35), e09307. (www)

  @article{ , abstract = {Coordinating transcription and replication via transcription factors (TFs) is a conserved mechanism in higher eukaryotes. The role of TFs in regulating these processes in cancers remains unclear. Here, it is shown that oncogenetic ETS transcription factor ETV4 controls DNA replication through both transcriptional and non-transcriptional mechanisms in non-small cell lung cancer (NSCLC). ETV4 localizes to specific DNA replication origins and interacts with the origin recognition complex subunits ORC1 and ORC6 during the G1/S phase, facilitating origin formation. Using quantitative in situ analysis of protein interactions at DNA replication forks (SIRF) assays, it is shown that ETV4 transiently localizes to replication forks in the S phase. It interacts with replicative helicase MCM2 N-terminal, histone H3, and histone-chaperone FACT and is involved in histone processing during replication. Additionally, ETV4 transcriptionally regulates key replisome genes MCM2, MCM4, MCM5, MCM10, and ORC1, influencing their expression and recruitment to chromatin. Due to its binding at the origin-promoter locus like the MCM4 gene, ETV4 overexpression increases R-loop formation, DNA damage, and cell death under external replication stress induced by topoisomerase I (TOP1) inhibitor. These findings highlight the dual role of ETV4 in replication and transcription and suggest that targeting TOP1 could be a synthetic-lethal approach in ETV4-overexpressed lung cancer.}, archive = {J_ADVS}, author = {Jiaxi Zhang and Yan Wang and Shanhu Cao and Shelly M. Xie and Bei Liu and Yimeng Li and Yuqi Hou and Xue Meng and Mingzhu Ruan and Di Bu and Jia Kang and Ruxin Li and Lei Lou and Juan Wang and Lingxiao Xing}, doi = {10.1002/advs.202409307}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e09307}, shortjournal = {Adv. Sci.}, title = {Topoisomerase i inhibition in ETV4-overexpressed non-small cell lung cancer promotes replication and transcription mediated R-loop accumulation and DNA damage}, volume = {12}, year = {2025}, }
• (2025). Mixed lineage kinase domain-like protein (MLKL): From mechanisms to therapeutic opportunities. ADVS, 12(35), e09277. (www)

  @article{ , abstract = {Lytic forms of regulated cell death (RCD) rely on the activation and recruitment of executioner proteins. The mixed lineage kinase domain-like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots. These mechanisms involve protein–protein interactions between receptor-interacting protein kinase 3 (RIPK3) and MLKL, MLKL phosphorylation, protein–protein interactions between MLKL and MLKL, and MLKL-lipid interactions. In this review, the specificity of MLKL activation mechanisms is discussed across different species and describe the processes by which MLKL transitions from an auto-inhibited to a membrane-embedded state. The opportunities are further explored for targeting MLKL, including small molecule inhibitors and functionally interacting proteins.}, archive = {J_ADVS}, author = {Lijuan Xu and Chunlin Zhuang}, doi = {10.1002/advs.202509277}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e09277}, shortjournal = {Adv. Sci.}, title = {Mixed lineage kinase domain-like protein (MLKL): From mechanisms to therapeutic opportunities}, volume = {12}, year = {2025}, }
• (2025). Hyperspectral fluorescence imaging with a new polarity-ultrasensitive fluorescent probe. ADVS, 12(35), e08792. (www)

  @article{ , abstract = {Hyperspectral fluorescence imaging (HSFI) could simultaneously offer morphological visualization and microenvironmental information through fluorescence wavelength-shifting of microenvironmental-sensitive fluorescent probes, yet its advancement is directly hindered by the scarcity of probes with sufficient spectral sensitivity. Herein, this study focuses on the development of an innovative fluorescent probe that exhibits heightened spectral sensitivity to microenvironmental changes and its advanced HSFI application. First, the comprehensive investigation of various donor-π-acceptor molecules uncovers the critical role of π-spacer on the wavelength sensitivity to microenvironment polarity. Based on this insight, a new fluorescent probe Lipi-PS of whose wavelength sensitivity represents the highest level so far is rationally developed. Further combining with the features of lipid droplets (LDs) targeting and high photostability of Lipi-PS , as well as the newly established wavelength and polarity encoding method, HSFI is successfully realized in cells, tissues, and zebrafishes. Accordingly, the structural morphologies, fluorescence wavelengths, and polarities are intuitively visualized in the HSFI images. Notably, a special HSFI of single LD is achieved using Lipi-PS in a custom-built 3D-SpecDIM system, allowing 5D tracking ( xyzλt ) of individual LDs for the first time. This enables unprecedented correlation of polarity-dynamic behavior at the single-LD level.}, archive = {J_ADVS}, author = {Ri Zhou and Hao Sha and Shengjie Fu and Guannan Liu and Jinbei Wei and Chenguang Wang and Shangguo Hou and Geyu Lu}, doi = {10.1002/advs.202508792}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e08792}, shortjournal = {Adv. Sci.}, title = {Hyperspectral fluorescence imaging with a new polarity-ultrasensitive fluorescent probe}, volume = {12}, year = {2025}, }
• (2025). FOXM1 protects against myocardial ischemia-reperfusion injury in rodent and porcine models by suppressing MKRN1-dependent LKB1 ubiquitination. ADVS, 12(35), e08673. (www)

  @article{ , abstract = {Mitochondrial dysfunction is related to etiopathogenesis and progression of heart failure (HF). The underlying molecular mechanisms are not fully understood. Transcription factor FOXM1 plays an essential role in cardiovascular development. The present study explores its role in mitochondrial bioenergetics in postmitotic cardiomyocytes (CMs). FOXM1 is significantly upregulated in ischemic heart tissues from humans, mice, and pigs. CM-specific Foxm1 -knockout mice exhibit dilated cardiomyopathy features associated with mitochondrial dysfunction. Transcriptomic and proteomic profiling of Foxm1 -knockout mice reveal robust, specific downregulation of gene programs important for mitochondrial energetics and homeostasis. Analysis of proteome and ubiquitinome data reveal that FOXM1 deficiency in CMs promotes LKB1 ubiquitination and impairs the AMPK signaling and energy metabolism pathways. Bioinformatics analysis identifies that E3 ligase MKRN1 promotes the K48-linked ubiquitination of LKB1 on Lys146, which in turn, inhibits the AMPK signaling pathway and impairs energy homeostasis in mice with HF. CM-specific Mkrn1 knockout ameliorates cardiac dysfunction by rejuvenating the impaired mitochondrial bioenergetics induced by FOXM1 deficiency. FOXM1 overexpression preserves mitochondrial bioenergetics and protects against myocardial I/R injury in both rodent and porcine models. In conclusion, FOXM1 is actively involved in mitochondrial bioenergetics during HF. FOXM1 may be a potential promising therapeutic target for myocardial I/R injury and HF.}, archive = {J_ADVS}, author = {Shuai Song and Xiaokai Zhang and Zihang Huang and Zhiqiang Pei and Linqi Zeng and Fengze Cai and Tongyao Wang and Mohan Li and Chenyan Liu and Yining Song and Jiahao Guo and Hao Lu and Xinyu Weng and Li Shen and Xiaochun Zhang and Xingxing Cai and Aijun Sun and Junbo Ge}, doi = {10.1002/advs.202508673}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e08673}, shortjournal = {Adv. Sci.}, title = {FOXM1 protects against myocardial ischemia-reperfusion injury in rodent and porcine models by suppressing MKRN1-dependent LKB1 ubiquitination}, volume = {12}, year = {2025}, }
• (2025). Mechanisms of in situ growth of (Fe4Al3Cr)0.25TiO5 whisker driven by oxygen partial pressure and reinforced mechanical properties in corundum-type medium-entropy oxides. ADVS, 12(35), e08378. (www)

  @article{ , abstract = {Designing in situ whiskers to enhance the fracture toughness of ceramics presents challenges for structural applications. Herein, two corundum-type medium-entropy oxide ceramics (MEO-1 and MEO-2) are synthesized through solid-state reaction sintering under controlled oxygen partial pressures. MEO-1 is a single-phase corundum-type oxide (Al 0.41 Cr 0.26 Fe 0.31 Ti 0.02 ) 2 O 3 , while MEO-2 incorporates (Fe 4 Al 3 Cr) 0.25 TiO 5 whiskers to reinforce (Al 0.40 Cr 0.25 Fe 0.30 Ti 0.05 ) 2 O 3 . By regulating variable valence ions at different oxygen partial pressures, the whiskers achieved a maximum average length of 28.3 µm and a length-to-diameter ratio of 17.7 at 50.6 kPa, significantly enhancing the fracture toughness of the MEO-2, which possesses the optimal flexural strength, Vickers hardness, and fracture toughness of 321 ± 8 MPa, 22.4 ± 1.5 GPa, and 3.87 ± 0.12 MPa m 1/2 , respectively. Bravais–Friedel–Donnay–Harker law (BFDH) simulation elucidates that oxygen partial pressures can effectively regulate ionic diffusion behavior and whisker growth. First-principles calculations demonstrate that the whisker growth direction [0 4 0] aligns with the high shear modulus direction, contributing to the strengthening mechanism. This work provides new insights for designing high-performance medium/high-entropy ceramics, highlighting the critical role of oxygen partial pressure in regulating whisker growth and improving mechanical properties.}, archive = {J_ADVS}, author = {Wenxue Wang and Kang Wang and Chao Ma and Wei Yang and Junpeng Jiang and Rui Zhao and Daoyang Han and Hailong Wang and Rui Zhang}, doi = {10.1002/advs.202508378}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e08378}, shortjournal = {Adv. Sci.}, title = {Mechanisms of in situ growth of (Fe4Al3Cr)0.25TiO5 whisker driven by oxygen partial pressure and reinforced mechanical properties in corundum-type medium-entropy oxides}, volume = {12}, year = {2025}, }
• (2025). Biodegradable medical implants: Reshaping future medical practice. ADVS, 12(35), e08014. (www)

  @article{ , abstract = {Biodegradable medical implants have fundamentally transformed the field of biomedical engineering by providing sustainable and biocompatible alternatives that obviate the need for secondary surgical removal and facilitate endogenous tissue regeneration. This comprehensive review systematically evaluates recent advancements in biodegradable implants utilized across a spectrum of medical applications, including internal medicine, surgical interventions, and medical devices. The developments discussed herein signify substantial progress in material synthesis, characterization, and processing techniques, effectively addressing critical challenges associated with the integration of biodegradable devices into medical implants. Although biodegradable medical implants promise advanced patient care, widespread clinical translation is hindered by inconsistent degradation rates mismatched with healing timelines, insufficient load-bearing strength, and potential inflammatory or toxic by-products. Additionally, most studies exhibit application-material imbalances, inadequate in vivo validation, and poorly controlled degradation behavior. Future efforts must clarify degradation mechanisms and treat materials as therapeutic agents. By synthesizing recent findings and highlighting critical gaps, this review provides valuable insights to guide innovation in biodegradable implant technologies, ultimately enhancing clinical outcomes and accelerating regenerative medicine's progress. Addressing these challenges is crucial for realizing their full clinical potential.}, archive = {J_ADVS}, author = {Bo Xia and Yan Liu and Yangkun Xing and Zhewei Shi and Xiaocheng Pan}, doi = {10.1002/advs.202508014}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e08014}, shortjournal = {Adv. Sci.}, title = {Biodegradable medical implants: Reshaping future medical practice}, volume = {12}, year = {2025}, }
• (2025). Industrial alkaline electrolyzers enabled by interface-engineered cobalt oxide electrodes for high-efficiency water splitting. ADVS, 12(35), e08013. (www)

  @article{ , abstract = {Alkaline (ALK) electrolysis is an important means to generate green hydrogen from water splitting, and its technical advance hinges critically on the breakthrough of catalytic electrodes capable of high current densities at low overpotentials. Here, an efficient and robust hydrogen-evolving electrode is developed, composed of cobalt oxide (Co 3 O 4 ) nanosheet catalyst with a metal cobalt transition interface on the current-collecting nickel wire mesh substrate. This Co 3 O 4 electrode affords a unique charge avalanche effect at the metal–semiconductor interface to concentrate electron release and thus enables high-current-density hydrogen evolving at 1000 mA cm −2 with only 207 mV overpotential, far outperforming commercial Raney nickel electrode that commonly delivers current densities below 500 mA cm −2 at 300–500 mV overpotentials. An industrial cell-stack electrolyzer utilizing Co 3 O 4 electrodes achieves a consistent current density of 1000 mA cm −2 at a 2.0 V cell voltage, surpassing the operational current density of commercial ALK systems by two to five times (200–500 mA cm −2 ). A significant enhancement in current output and a minimal deactivation rate of only 0.056 mV h −1 demonstrate the potential of the Co 3 O 4 electrode to replace commercial Raney nickel electrode, thereby substantially improving the hydrogen production efficiency of ALK electrolyzers.}, archive = {J_ADVS}, author = {Cheng Li and Xuyu Luo and Ying Wang and Mingze Zhu and Dan Li and Shiying Guo and Wei Wang and Xiaoyong Xu}, doi = {10.1002/advs.202508013}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e08013}, shortjournal = {Adv. Sci.}, title = {Industrial alkaline electrolyzers enabled by interface-engineered cobalt oxide electrodes for high-efficiency water splitting}, volume = {12}, year = {2025}, }
• (2025). Low-power tunable micro-plasma device for efficient and scalable CO2 valorization. ADVS, 12(35), e07687. (www)

  @article{ , abstract = {Valorizing CO 2 into chemical building blocks via efficient electrified processes could significantly decrease carbon emissions. In this work, a device that allows generation of tunable micro-plasma modes (arc, pulsed, pulsed arc) on a chip for efficient, low-power and renewable chemical production is presented. This concept is first demonstrated by using nanosecond repetitively pulsed (NRP) micro-plasma for pure CO 2 splitting and show that the pulse micro-plasma maintains a peak energy efficiency of 29% across 0.2%–21% CO 2 conversion at plasma powers below 1 W-nearly an order of magnitude lower power than other systems with comparable performance. The kinetic studies feature pulsed arc mode as a novel way to improve CO 2 conversion, where CO production tripled compared to pulsed mode with negligible energy efficiency losses. In addition, these devices are also capable of performing dry reforming of methane (DRM) with a maximum energy efficiency of 33% and a syngas ratio close 1. The fact that these devices are low-power, versatile and built as chips enables scalable, sustainable and decentralized CO 2 conversion.}, archive = {J_ADVS}, author = {Bartu Karakurt and Hongkeng Zhu and Onder Soydal and Guangyu Sun and Jeremy S. Luterbacher and Elison Matioli}, doi = {10.1002/advs.202507687}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07687}, shortjournal = {Adv. Sci.}, title = {Low-power tunable micro-plasma device for efficient and scalable CO2 valorization}, volume = {12}, year = {2025}, }
• (2025). Metal-less top electrode semitransparent organic solar modules with an average visible transmission of 51% and a light utilization efficiency of 4%. ADVS, 12(35), e07521. (www)

  @article{ , abstract = {Semitransparent organic modules (STOMs) are of particular interest due to potential applications in building-integrated photovoltaics though upscaling without significant performance losses while ensuring an aesthetic appearance for window applications remains a major research obstacle. This study presents two types of STOMs with an area of 11.4 cm 2 , exhibiting homogeneous appearance while retaining up to 92% of their respective small-area cell power conversion efficiency (PCE). Precise laser structuring minimized the area loss originating from the sub-cell series interconnection, allowing narrow cell stripes down to 1.25 mm. This enables a metal-less top electrode composed solely of PEDOT:PSS without compromising fill factor. For a module, an additional challenge is to ensure a low resistance series interconnection between sub-cells. This is realized with a novel approach based on a direct contact between PEDOT:PSS and a thin Ag layer within the back electrode. For the first design, the latter incorporates Al-doped ZnO and Ag attaining a PCE of 6.1% with an average visible transmission (AVT) of 47.5%. A more elaborate design features an extended back electrode using TiO 2 and SiO 2 for improved optical performance (PCE = 7.9%), reaching an unprecedented AVT of 50.8% and a light utilization efficiency (LUE = AVT x PCE) of 4.0%.}, archive = {J_ADVS}, author = {Leonie Pap and Mathias List and René Haberstroh and Lasse Bienkowski and Martin Mattenheimer and Thomas Kroyer and Jared Faisst and Birger Zimmermann and Uli Würfel}, doi = {10.1002/advs.202507521}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07521}, shortjournal = {Adv. Sci.}, title = {Metal-less top electrode semitransparent organic solar modules with an average visible transmission of 51% and a light utilization efficiency of 4%}, volume = {12}, year = {2025}, }
• (2025). New strategy for cluster-based covalent organic framework: Thermally induced covalent crosslinking of highly stable copper clusters. ADVS, 12(35), e07510. (www)

  @article{ , abstract = {Copper nanoclusters (Cu NCs) have emerged as a remarkable class of CO 2 reduction reaction catalysts that are distinguished by their unparalleled reactivity, but effectively modulating the transport pathway of charge carriers between Cu NCs by feasible chemical means is still challenging. Herein, a thermally induced covalent crosslinking strategy is proposed to modulate the fast electron transport pathway formed between clusters. A copper-sulfur–nitrogen cluster [Cu 4 (SN) 4 ] (denoted Cu 4 SN ) is first synthesized; subsequently, the SN ligands in Cu 4 SN are coupled covalently via a thermally induced covalent crosslinking strategy to yield CC –Cu 4 SN , which exhibits enhanced conductivity and photocarrier transport. As expected, CC –Cu 4 SN shows a high photocatalytic CO production rate of 29.98 µmol g −1 h −1 with ≈99.5% selectivity in CO 2 reduction with H 2 O as sacrificial agents, which is more than 10 times superior to that observed with Cu 4 SN . Systematic experiments and density functional theory calculations reveal that the covalent crosslinks between clusters accelerate the dynamic transfer of photoexcited charge carriers, increase the light utilization ability, favor CO 2 adsorption and * COOH generation, thereby accounting for the increased CO 2 photoreduction activity. This work presents a novel thermally induced internal covalent crosslinking strategy for synthesizing novel cluster-based covalent polymers with enhanced stability and catalytic activity.}, archive = {J_ADVS}, author = {Jian-Peng Dong and Yue Xu and Ling Yao and Le Wang and Gang Li and Rui Wang and Shuang-Quan Zang}, doi = {10.1002/advs.202507510}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07510}, shortjournal = {Adv. Sci.}, title = {New strategy for cluster-based covalent organic framework: Thermally induced covalent crosslinking of highly stable copper clusters}, volume = {12}, year = {2025}, }
• (2025). Accelerating combinatorial electrocatalyst discovery with bayesian optimization: A case study in the quaternary system ni-pd-pt-ru for the oxygen evolution reaction. ADVS, 12(35), e07302. (www)

  @article{ , abstract = {The discovery of high-performance electrocatalysts is crucial for advancing sustainable energy technologies. Compositionally complex solid solutions comprising multiple metals offer promising catalytic properties, yet their exploration is challenging due to the combinatorial explosion of possible compositions. In this work, human-decision driven combinatorial sputtering of thin-film materials libraries and high-throughput characterization is combined with Bayesian optimization to efficiently explore the quaternary composition space Ni-Pd-Pt-Ru for the oxygen evolution reaction (OER) in alkaline media. Using this method, the global activity optimum of pure Ru is identified after covering less than 20% of the complete composition space with six materials libraries. Six additional libraries are fabricated to validate the activity trend. The resulting dataset is used to formulate general guidelines for the efficient composition of space exploration with combinatorial synthesis paired with Bayesian optimization.}, archive = {J_ADVS}, author = {Felix Thelen and Rico Zehl and Ridha Zerdoumi and Jan Lukas Bürgel and Lars Banko and Wolfgang Schuhmann and Alfred Ludwig}, doi = {10.1002/advs.202507302}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07302}, shortjournal = {Adv. Sci.}, title = {Accelerating combinatorial electrocatalyst discovery with bayesian optimization: A case study in the quaternary system ni-pd-pt-ru for the oxygen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). ALKBH5-mediated M6A demethylation of G3BP1 attenuates ferroptosis via cytoplasmic retention of YBX1/p53 in diabetic myocardial ischemia-reperfusion injury. ADVS, 12(35), e07254. (www)

  @article{ , abstract = {The overexpression of ALKBH5 alleviates damage to cardiomyocytes and tissues, decreases the expression of SLC7A11, and inhibits the expression of p53 N/T and ferroptosis. ALKBH5 induces ferroptosis in the HH/R model by mutating the 3′-UTR of G3BP1 mRNA and m 6 A sites at positions 142 and 173. Mutations of sites 142 and 173 only partially affect the levels of p53 N/T , SLC7A11 and ferroptosis. G3BP1, YBX1 and p53 protein can bind to each other, and p53 can inhibit the expression of SLC7A11 via nuclear binding to the promoter region of SLC7A11 mRNA. The p53 and YBX1 proteins can synergistically enter the nucleus to aggravate cell damage, while G3BP1 is expressed in the cytoplasm and inhibits p53 binding to SLC7A11 by blocking the entry of the p53 and YBX1 proteins into the nucleus. ALKBH5 promotes G3BP1 expression through m 6 A methylation at m 6 A sites 142 and 173. Subsequently, G3BP1, YBX1, and p53 interact with each other, the amount of synergistic nuclear translocation of YBX1 and p53 is reduced, and the level of p53 nuclear translocation that inhibiting SLC7A11 transcription is decreased, thereby inhibits cardiomyocyte ferroptosis and reducing myocardial tissue damage during myocardial IRI in diabetes.}, archive = {J_ADVS}, author = {Wenyuan Li and Wei Li and Yan Leng and Heng Xu and Zhongyuan Xia and Yao Wang}, doi = {10.1002/advs.202507254}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07254}, shortjournal = {Adv. Sci.}, title = {ALKBH5-mediated M6A demethylation of G3BP1 attenuates ferroptosis via cytoplasmic retention of YBX1/p53 in diabetic myocardial ischemia-reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Sweat wearable sensor based on confined pt nanoparticles in 2D conductive Metal–Organic frameworks for continuous glucose monitoring. ADVS, 12(35), e07212. (www)

  @article{ , abstract = {The noninvasive glucose sensors with comprehensive functional capabilities can enable wearable glucose monitoring in sweat with high sensitivity and minimal risk. However, the limited stability of natural enzymes, along with interference from electro-oxidizable species, continues to pose significant challenges for their long-term application. Herein, an integrated wearable system is presented for nonenzymatic glucose monitoring in sweat at the point of care. This system integrates a flexible microfluidic glucose sensor patch for sweat sampling and measurement, using Pt nanoparticles (Pt-NPs) confined within phthalocyanine-based conductive metal–organic frameworks (Pc-MOFs) as electrode materials, and a flexible printed circuit board for signal/analysis and wireless communication. The microfluidic sensor patch based on Pc-MOFs confined Pt-NPs exhibits significantly improved nonenzymatic glucose sensing performances. This is attributed to the ultrasmall size of Pt-NPs and the confinement effect within the Pc-MOF channels, which regulates the glucose adsorption intensity and increases the electrocatalytic activity to glucose oxidation. During the continuous monitoring process, the glucose concentration is calibrated in sweat by accounting for fluctuations in pH and temperature, and evaluated the performance of the wearable device in monitoring sweat glucose levels in human subjects over a 12-h period, achieving data as accurate as that obtained using high-performance liquid chromatography.}, archive = {J_ADVS}, author = {Wei Huang and Yong Yang and Yun Xu and Fei Xiao and Lin Wang}, doi = {10.1002/advs.202507212}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07212}, shortjournal = {Adv. Sci.}, title = {Sweat wearable sensor based on confined pt nanoparticles in 2D conductive Metal–Organic frameworks for continuous glucose monitoring}, volume = {12}, year = {2025}, }
• (2025). Recent developments in nanoparticle-hydrogel hybrid materials for controlled release. ADVS, 12(35), e07209. (www)

  @article{ , abstract = {Nanoparticle (NP)–hydrogel hybrid materials have emerged as promising platforms for controlled drug delivery, combining the tunable chemistry of NPs (e.g., liposomes, polymeric, and inorganic NPs) with the porous, biocompatible networks of hydrogels (e.g., alginate or poly(ethylene glycol)-based systems). These composites can encapsulate a wide range of bioactive agents—small molecules, peptides, proteins, and nucleic acids—within hydrogel matrices, guided by molecular interactions such as electrostatic forces, hydrogen bonding, and hydrophobic/hydrophilic balance. Such interactions influence both the physicochemical stability and drug release profiles of the system. This review highlights recent advances in NP–hydrogel composites, emphasizing how molecular-level interactions shape the nanostructure, drug encapsulation, and release behavior. The enhanced mechanical strength, stimuli responsiveness, pharmacokinetics, and biological performance of these materials are also discussed. Particular focus is placed on how improved mechanistic understanding can guide the design of next-generation hybrid systems with tunable, predictable release for biomedical applications. This review provides a comprehensive overview of NP–hydrogel hybrid materials as versatile drug delivery systems and outlines future research directions for their use in personalized therapy, targeted treatment, and broader clinical translation.}, archive = {J_ADVS}, author = {Yiping Fan and Qi Han and Haiyan Li and Xudong Cai and Brendan Dyett and Ruirui Qiao and Calum J. Drummond and San H. Thang and Jiali Zhai}, doi = {10.1002/advs.202507209}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07209}, shortjournal = {Adv. Sci.}, title = {Recent developments in nanoparticle-hydrogel hybrid materials for controlled release}, volume = {12}, year = {2025}, }
• (2025). Plasmon-driven reorientation of interfacial water for wastewater electrolysis with light-emitting diode illumination. ADVS, 12(35), e07147. (www)

  @article{ , abstract = {Regulating the orientation and dynamics of interfacial water is essential for optimizing electrocatalytic reactions, yet it remains challenging due to its intrinsic disorder. Here, it is demonstrated that localized surface plasmon resonance (LSPR) on an Ir single-atom Au catalyst actively restructures the hydrogen-bond (HB) network, accelerating ammonia oxidation reaction kinetics. In situ Raman spectroscopy and density functional theory calculations reveal that plasmonic excitation shifts the HB network toward a more flexible configuration, favoring the formation of three-coordinated hydrogen-bonded water (3HB·H 2 O) while suppressing cation-associated species (K + ·H 2 O). This transformation enhances the dehydrogenation process and stabilizes reaction intermediates, leading to a 28% increase in NH 3 oxidation kinetics. Operando X-ray absorption spectroscopy further confirms that LSPR-driven polarization at the Ir active site compresses the Ir─O bond from 1.73 to ≈1.58 Å by generating electron vacancies, thereby accelerating deprotonation with * OH during oxidative electrolysis. Extending this principle to an LED-driven plasmon-assisted symmetric wastewater electrolyzer, achieving a 40-fold current enhancement and 94% ammonia removal efficiency over 120 h at 1 V under landfill leachate-like conditions.}, archive = {J_ADVS}, author = {Nur Aqlili Riana Che Mohamad and Kyunghee Chae and Qiang Zhou and Wen-Tse Huang and Hyun Jeong Lee and Jaehyun Son and Jooho Moon and Yunfei Bu and Feng Gong and Ru-Shi Liu and Jeongwon Kim and Dong Ha Kim}, doi = {10.1002/advs.202507147}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07147}, shortjournal = {Adv. Sci.}, title = {Plasmon-driven reorientation of interfacial water for wastewater electrolysis with light-emitting diode illumination}, volume = {12}, year = {2025}, }
• (2025). Electrochemical degradation of plastic waste coupled with hydrogen evolution in seawater using rosette-like high-entropy oxides. ADVS, 12(35), e07023. (www)

  @article{ , abstract = {Plastic overproduction and improper disposal generates over 390 million tons of waste annually, severely polluting marine ecosystems. Polyglycolic acid (PGA) is widely used in biomedical and packaging fields. Here, this study introduces an electrochemical degradation strategy for PGA waste that couples its conversion with seawater-driven hydrogen evolution reaction (HER) using rosette-like high-entropy NiCoFeMnAlO x nanosheets (r-NCFMAO). The PGA-derived glycolic acid oxidation reaction (GAOR) achieves 100 mA cm −2 at 1.36 V versus RHE, benefiting from abundant hydroxyl species (OH*) that lower the required potential by over 190 mV compared to the oxygen evolution reaction. This method produces ≈90% CO 3 2− , and subsequent Ca 2+ precipitation recovers 77% of CaCO 3 , a valuable material in construction and papermaking. Electrochemical analysis, quasi in situ electron paramagnetic resonance, and in situ Raman spectroscopy reveal continuous OH − oxidation enhancing GAOR activity, while density functional theory confirms that OH* lowers the energy barrier for the rate-determining C─C bond cleavage and C─H bond activation. The integrated GAOR ‖ HER system sustains performance for over 300 h at industrial current densities and is applicable to upcycling various plastics. This work pioneers a synergistic approach for plastic waste valorization and hydrogen production, advancing circular carbon strategies.}, archive = {J_ADVS}, author = {Zhenhao Xu and Yuchen Wang and Zhikeng Zheng and Xiaodie Zhang and Bin Liu and Karen Wilson and Kai Yan}, doi = {10.1002/advs.202507023}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e07023}, shortjournal = {Adv. Sci.}, title = {Electrochemical degradation of plastic waste coupled with hydrogen evolution in seawater using rosette-like high-entropy oxides}, volume = {12}, year = {2025}, }
• (2025). Low-temperature annealing triggered abnormal strengthening in a complex concentration alloy via evolutive short-range ordering. ADVS, 12(35), e06962. (www)

  @article{ , abstract = {Low-temperature annealing is traditionally employed to relieve residual stresses in metallic materials, typically resulting in softening. However, a novel finding in the face-centered-cubic (fcc) CoNiV medium entropy alloy (MEA) is reported, where low-temperature annealing induces significant hardening without sacrificing ductility. Specifically, after annealing at 530 °C, the yield strength increases from 503 to 653 MPa, while maintaining plasticity of ≈60%. The comprehensive analysis reveals that this unexpected strengthening is attributed to the development of multi-scale chemical short-range orderings (SROs) during the annealing process. These SROs, particularly a newly formed L12-type ordered structure (SRO-2), enhance material strength by promoting dislocation slip planarity and reducing dislocation entanglement. This study demonstrates that low-temperature annealing can effectively optimize atomic-scale structures in complex alloys distinct from that in conventional alloys, thereby improving their mechanical properties. These findings extend the conventional understanding of annealing effects and highlight the potential for leveraging SROs to design high-performance materials.}, archive = {J_ADVS}, author = {Yihan Wang and Yuan Wu and Yong Yu and Yang He and Xinyang Yu and Xiongjun Liu and Hui Wang and Suihe Jiang and Xiaobin Zhang and Zhaoping Lu}, doi = {10.1002/advs.202506962}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06962}, shortjournal = {Adv. Sci.}, title = {Low-temperature annealing triggered abnormal strengthening in a complex concentration alloy via evolutive short-range ordering}, volume = {12}, year = {2025}, }
• (2025). Flame-retardant ionogel enabled by lignin molecular networks for fire rescue. ADVS, 12(35), e06901. (www)

  @article{ , abstract = {Ionogel intended for fire environments encounters considerable challenges stemming from intrinsic limitations, such as inadequate heat resistance and potential damage to their structural networks. Here, a glycol lignin ionogel (GLI) with integrated flame-retardant, waterproof, and sensing capabilities for smart firefighting auxiliary equipment is presented. The ionogel, synthesized from the molecular network construction of Gly-lignin, 1-butyl-3-vinylimidazole tetrafluoroborate (BVIMBF 4 ), and benzyl methacrylate (BZMA), forms a stable and elastic 3D conductive network through both chemical and physical crosslinking. This structure imparts remarkable mechanical properties, including considerable adhesion (30.4 kPa on flame-retardant gloves), tensile strength (5.8 MPa), and high ionic conductivity. Notably, through the formation of a protective carbonized/B₂O₃ layer and chemical barrier gases during combustion, the ionogel exhibits excellent flame retardancy, with a weight loss of 41.8% at 800 °C. Additionally, GLI achieves real-time thermal sensing via its negative temperature coefficient (NTC) behavior (TCR = −0.58% °C −1 ). Even after exposure to fire, GLI retains its temperature and motion-sensing capabilities. Moreover, GLI demonstrates favorable biocompatibility and environmental degradability, broadening its applicability in sustainable and wearable electronics. The work provides new insights for the preparation of the next generation of fireproof multifunctional intelligent sensors.}, archive = {J_ADVS}, author = {Zewei Ye and Haomeng Yu and Hongxia Xie and Wenwen Zhu and Shitao Shi and Chencong Liu and Yuanyuan Wang and Jiaqi Liao and Qingfeng Sun and Dawei Zhao and Xiaoping Shen}, doi = {10.1002/advs.202506901}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06901}, shortjournal = {Adv. Sci.}, title = {Flame-retardant ionogel enabled by lignin molecular networks for fire rescue}, volume = {12}, year = {2025}, }
• (2025). Magnetic-driven viscous mechanisms in ultra-soft magnetorheological elastomers offer history-dependent actuation with reprogrammability options. ADVS, 12(35), e06790. (www)

  @article{ , abstract = {This work elucidates an important open question in the field of mechanically soft magnetorheological elastomers (MREs): how microstructural rearrangements during magnetic actuation modulate their viscoelastic behavior. Experimental assays are provided on mechanically confined and very soft MREs that, under magnetic actuation, show an order of magnitude increase in relaxation times compared to purely mechanical cases. It is demonstrated that such a modulation in the viscous response can be tuned by the amplitude and actuation rate of the magnetic stimuli, and is intrinsically linked to microstructural rearrangements of the magnetic particles. Motivated by these experimental observations, magnetic actuation protocols are conceived to enable mechanical responses in soft materials with force-memory. Specifically, due to the magnetically induced long-term viscous relaxation, one can induce magnetic-driven yielding by introducing material hardening during cycling loading. This mechanical memory of the MRE can be subsequently removed by releasing the magnetic stimuli for h, resetting the material performance and its microstructural state. These mechanisms are deeply understood by a combination of different experimental approaches and a new theoretical magneto-mechanical continuum model. The results reported herein respond to unraveled fundamental questions in soft MREs, and provide a game-changing concept for designing a new branch of soft sensor-actuator and reservoir computing systems.}, archive = {J_ADVS}, author = {Ernesto Gonzalez-Saiz and Maria Luisa Lopez-Donaire and Lucía Gutiérrez and Kostas Danas and Daniel Garcia-Gonzalez}, doi = {10.1002/advs.202506790}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06790}, shortjournal = {Adv. Sci.}, title = {Magnetic-driven viscous mechanisms in ultra-soft magnetorheological elastomers offer history-dependent actuation with reprogrammability options}, volume = {12}, year = {2025}, }
• (2025). Quantum valley hall effect-based coupler with continuously tunable transmission for topological information communication. ADVS, 12(35), e06732. (www)

  @article{ , abstract = {Topological insulators have taken classical wave systems to the next level by their unique characteristics such as highly efficient, robust, and unidirectional wave propagation. As a step further, tunability in fundamental building blocks such as couplers is desired toward topological integrated circuits and communication systems. However, most of existing topologically protected couplers exhibit a constant transmission coefficient within the bandgap, and achieving continuously tunable transmission coefficients remains challenging. Here it is experimentally showed that a four-port coupler consisting of quantum valley Hall effect-based waveguides can exhibit continuously tunable transmission coefficients from one input port to each of the two output ports over the bandgap, while the rest port is consistently isolated by the topological protection. Further topologically protected digital signal transfer is demonstrated with frequency shift keying modulation in the coupler, revealing the data-transfer capability close to the theoretical limit established in the digital communication scheme. These results pave the way for topological data transfer and signal processing.}, archive = {J_ADVS}, author = {Keita Funayama and Kenichi Yatsugi and Hiroya Tanaka and Hideo Iizuka}, doi = {10.1002/advs.202506732}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06732}, shortjournal = {Adv. Sci.}, title = {Quantum valley hall effect-based coupler with continuously tunable transmission for topological information communication}, volume = {12}, year = {2025}, }
• (2025). 3D hyperbolic kirigami metamaterials with tunable auxeticity and multistability. ADVS, 12(35), e06703. (www)

  @article{ , abstract = {Kirigami mechanical metamaterials provide exceptional tunability in mechanical properties and morphing capabilities, exhibiting great potential for deployable and actuatable devices. However, most kirigami structures can only deform freely within a 2D plane, with limited out-of-plane deformability, making them inadequate for constructing periodic objects with arbitrary 3D shapes. Here, a novel class of 3D mechanical metamaterials with hyperbolic kirigami tessellations has been developed. By projecting hyperbolic kirigami templates onto three types of triply periodic minimal surfaces, candidate structures are developed with remarkable properties. An extreme negative Poisson's ratio of -1 and tunable mechanical multistability are uncovered through theoretical analysis, numerical simulations, and experiments thanks to the flexible kirigami geometry. Notably, the structure achieves a maximum volume expansion of up to 488% during auxetic morphing. Furthermore, programmable morphing behaviors are demonstrated through voxelated assemblies of kirigami unit cells with varying geometrical parameters. The novel design strategy presented in this work based on hyperbolic kirigami tessellations opens up new avenues toward auxetic and multistable mechanical metamaterials with broad applications spanning shape-morphing architectures, deployable space structures, and soft machines.}, archive = {J_ADVS}, author = {Yu Lei and Yan Wang and Ruizhi Cui and Xiaolong Huang and Lei Zhang and Yuan Jin and Jinling Gao and Biwei Deng}, doi = {10.1002/advs.202506703}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06703}, shortjournal = {Adv. Sci.}, title = {3D hyperbolic kirigami metamaterials with tunable auxeticity and multistability}, volume = {12}, year = {2025}, }
• (2025). Base-mediated scalable synthesis of polybenzothiazoles: Fused-heterocycle-engineered recovery of precious metals. ADVS, 12(35), e06580. (www)

  @article{ , abstract = {Sulfur-containing fused heterocyclic polybenzothiazoles are promising materials with advanced functionalities, yet their synthesis has long been constrained by substrate limitations and scalability challenges. Here, a base-mediated multicomponent polymerization strategy using readily available elemental sulfur, aromatic diamines, and aromatic dialdehydes is developed to synthesize unprecedented polybenzothiazoles with scalability. By efficient alkaline activation of substrates through nucleophilic sulfurization-cyclization cascades, this method enables economically viable kilogram-scale production in a one-pot process with high yields (73–98%) and monomer universality, including previously incompatible electron-deficient aromatic amines. The resulting polybenzothiazoles unlock their long-overlooked potential in precious metal recovery, demonstrating selective, rapid, and efficient extraction (>99%) of gold (Au), palladium (Pd), and platinum (Pt) from ultra-trace concentrations (1 ppb) to complex matrices including surface water, e-waste, and spent catalyst leachates. Mechanistic studies reveal that the synergistic nitrogen (N)/sulfur (S) participation and π-conjugation in their fused heterocycles govern metal coordination selectivity and redox stability. This work establishes a practical yet versatile platform to advance polybenzothiazoles from synthesis to resource utilization, highlighting their transformative role in addressing critical challenges through adaptive material design and precious metal recovery.}, archive = {J_ADVS}, author = {Hongjie Zhou and Xiaoqiang An and Tianshu Zhang and Mingran Li and Lingru Kong and Huachun Lan and Huijuan Liu and Jiuhui Qu}, doi = {10.1002/advs.202506580}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06580}, shortjournal = {Adv. Sci.}, title = {Base-mediated scalable synthesis of polybenzothiazoles: Fused-heterocycle-engineered recovery of precious metals}, volume = {12}, year = {2025}, }
• (2025). Recent advances of microcapsule-based intelligent coatings: From bioinspired designs, material selections, to potential applications. ADVS, 12(35), e06557. (www)

  @article{ , abstract = {Coating technology is widely used in diverse fields such as energy, healthcare, and aerospace because of the advantages of simple fabrication, low cost, stability, and customized functions. However, conventional coatings fall short in meeting the emerging demands due to their single functionality and non-responsiveness. Inspired by natural prototypes, microcapsule-based intelligent coatings (MICs) that exhibit remarkable responsiveness to external stimuli have been developed and used in various fields such as corrosion protection and anti-fouling. Comprehensively understanding the responsive mechanisms and optimization strategies of MICs can maximize their adaptability and flexibility, which are highly desired for their precise preparation and actual applications. Therefore, this review focuses on recent progress of MICs, varying from bioinspired designs, material selections, stimulus responses, and diverse applications, providing more inspiration to design advanced MICs. First, biological prototypes used in the fabrication of MICs are briefly introduced. Then, the material selections and stimulus responses of MICs, as well as their advantages and disadvantages are emphasized. Later, applications are focused according to their functions, including anti-corrosion, anti-fouling, self-lubricating, and temperature regulation. Finally, the scientific challenges and prospects in designing MICs, focusing on the requirements of developing new structures using machine learning and achieving new applications, are highlighted.}, archive = {J_ADVS}, author = {Yue Zhao and Xiaopeng Cheng and Ran Zhao and Xipeng Li and Jingxin Meng and Shutao Wang}, doi = {10.1002/advs.202506557}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06557}, shortjournal = {Adv. Sci.}, title = {Recent advances of microcapsule-based intelligent coatings: From bioinspired designs, material selections, to potential applications}, volume = {12}, year = {2025}, }
• (2025). Inductive-associative meta-learning pipeline with human cognitive patterns for unseen drug-target interaction prediction. ADVS, 12(35), e06404. (www)

  @article{ , abstract = {Significant differences in protein structures hinder the generalization of existing drug-target interaction (DTI) models, which often rely heavily on pre-learned binding principles or detailed annotations. In contrast, BioBridge designs an Inductive-Associative pipeline inspired by the workflow of scientists who base their accumulated expertise on drawing insights into novel drug-target pairs from weakly related references. BioBridge predicts novel drug–target interactions using limited sequence data, incorporating multi-level encoders with adversarial training to accumulate transferable binding principles. On these principles basis, BioBridge employs a dynamic prototype meta-learning framework to associate insights from weakly related annotations, enabling robust predictions for previously unseen drug-target pairs. Extensive experiments demonstrate that BioBridge surpasses existing models, especially for unseen proteins. Notably, when only homologous protein binding data is available, BioBridge demonstrates robust efficacy for virtual screening of the epidermal growth factor receptor and adenosine receptor, underscoring its potential in drug discovery.}, archive = {J_ADVS}, author = {Xiaoqing Lian and Tianxu Lv and Jie Zhu and Shiyun Nie and Hang Fan and Guosheng Wu and Yunjun Ge and Hong Xu and Xiaoting Wang and Lihua Li and Xiangxiang Zeng and Xiang Pan}, doi = {10.1002/advs.202506404}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06404}, shortjournal = {Adv. Sci.}, title = {Inductive-associative meta-learning pipeline with human cognitive patterns for unseen drug-target interaction prediction}, volume = {12}, year = {2025}, }
• (2025). Flexible dual-modal sensors based on single-crystalline silicon membranes for continuous monitoring of photoplethysmography and skin temperature. ADVS, 12(35), e06348. (www)

  @article{ , abstract = {Flexible dual-modal sensors that can monitor two signals play important roles in biomedical applications, along with the recent progresses of epidermal or bioimplantable electronic devices with diagnostic or therapeutic functionalities. However, techniques for flexible dual-modal sensors mainly rely on integrating multiple sensing units on a platform, thus inducing extra costs and complexities associated with the fabrication and data processing. In this paper, a flexible dual-modal sensor is presented, which contains only one sensing unit, i.e., single-crystalline silicon-based diode, for the real-time, independent, and continuous monitoring of light and temperature. Operation modes for photodetection and temperature sensing of the flexible dual-modal sensor are switchable by controlling the biased condition. In addition, both experimental results and theoretical calculations indicate that the crosstalk between light and temperature can be conveniently decoupled by short-circuit current and forward current of silicon-based diodes. Finally, the flexible dual-modal sensor is implemented as a platform to realize the continuous monitoring of photoplethysmography (PPG) and skin temperature of fingertips. These presented results offer paths to the construction of multifunctional, flexible bioelectronic devices or integrated platforms for biomedical uses.}, archive = {J_ADVS}, author = {Yanle He and Haonan Zhao and Xiaozhong Wu and Junjie Zhou and Ailing Yin and Deyu Meng and Wenli Sun and Qinglei Guo}, doi = {10.1002/advs.202506348}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06348}, shortjournal = {Adv. Sci.}, title = {Flexible dual-modal sensors based on single-crystalline silicon membranes for continuous monitoring of photoplethysmography and skin temperature}, volume = {12}, year = {2025}, }
• (2025). Born to fear the machine? genetic and environmental influences on negative attitudes toward AI agents. ADVS, 12(35), e06262. (www)

  @article{ , abstract = {Despite the rapid development of artificial intelligence (AI) agents, substantial individual differences in public acceptance persist. To explain the difference in attitudes toward AI agents, existing research has primarily focused on environmental factors. However, evolutionary psychology research suggests that the mechanism of outgroup rejection has a genetic basis, highlighting the need to explore the potential genetic underpinnings of negative attitudes toward AI agents as an outgroup in human society. This study examines the genetic basis of negative attitudes toward AI agents and their relationship with related personality traits, using a twin study design to assess negative attitudes toward AI agents, victim sensitivity, and moral preferences. Univariate genetic analyses revealed significant heritability of these negative attitudes. Bivariate analyses further identify shared genetic influences between victim sensitivity and personal-level fear and wariness toward robots. Similarly, a shared genetic basis is observed between the moral preferences concerning authority and sociotechnical blindness anxiety toward AI agents. These findings extend the understanding of social cognition in AI agents by emphasizing the role of genetic factors in shaping attitudes toward them. Moreover, they provide new insights for enhancing public acceptance of AI agents and optimizing human-machine interactions.}, archive = {J_ADVS}, author = {Xiaojiayu Tan and Yue He and Yuan Zhou and Xinying Li and Qingwen Ding and Yikai Tang and Yu L. L. Luo and Ruolei Gu}, doi = {10.1002/advs.202506262}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06262}, shortjournal = {Adv. Sci.}, title = {Born to fear the machine? genetic and environmental influences on negative attitudes toward AI agents}, volume = {12}, year = {2025}, }
• (2025). Quantum kernel learning for small dataset modeling in semiconductor fabrication: Application to ohmic contact. ADVS, 12(35), e06213. (www)

  @article{ , abstract = {Modeling complex semiconductor fabrication processes such as Ohmic contact formation remains challenging due to high-dimensional parameter spaces and limited experimental data. While classical machine learning (CML) approaches have been successful in many domains, their performance degrades in small-sample, nonlinear scenarios. In this work, quantum machine learning (QML) is investigated as an alternative, exploiting quantum kernels to capture intricate correlations from compact datasets. Using only 159 experimental GaN HEMT samples, a quantum kernel-aligned regressor (QKAR) is developed combining a shallow Pauli-Z feature map with a trainable quantum kernel alignment (QKA) layer. All models, including seven baseline CML regressors, are evaluated under a unified PCA-based preprocessing pipeline to ensure a fair comparison. QKAR consistently outperforms classical baselines across multiple metrics (MAE, MSE, RMSE), achieving a mean absolute error of 0.338 Ω·mm when validated on experimental data. Noise robustness and generalization are further assessed through cross-validation and new device fabrication. These findings suggest that carefully constructed QML models can provide predictive advantages in data-constrained semiconductor modeling, offering a foundation for practical deployment on near-term quantum hardware. While challenges remain for both QML and CML, this study demonstrates QML's potential as a complementary approach in complex process modeling tasks.}, archive = {J_ADVS}, author = {Zeheng Wang and Fangzhou Wang and Liang Li and Zirui Wang and Timothy van der Laan and Ross C. C. Leon and Jing-Kai Huang and Muhammad Usman}, doi = {10.1002/advs.202506213}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06213}, shortjournal = {Adv. Sci.}, title = {Quantum kernel learning for small dataset modeling in semiconductor fabrication: Application to ohmic contact}, volume = {12}, year = {2025}, }
• (2025). Synergistic enhancement effect of maxwell polarization and preferential exposure of zn (101) plane toward superhydrophobic separator for ah-level zinc metal pouch batteries. ADVS, 12(35), e06035. (www)

  @article{ , abstract = {Interfacial instability in aqueous zinc metal batteries (AZMBs) leads to uncontrolled dendrite growth and water-induced parasitic reactions, limiting their practical applications. In this work, a novel superhydrophobic HfO 2 -coated functionalized glass fiber separator is proposed. Characterized by its high dielectric constant, HfO 2 can autonomously generate an oriented electric field under external electric field stimulation, ensuring uniform distribution of the electric field and Zn 2+ flux at the interface. This strategy not only enhances Zn 2+ transport kinetics but also effectively suppresses the migration of SO 4 2− via electrostatic repulsion. Furthermore, the HfO 2 @GF separator promotes the deposition of Zn 2+ along the Zn (100) and Zn (002) crystal planes, facilitating the preferential exposure of the unique Zn (101) crystal plane. Additionally, its superhydrophobic property effectively inhibits interfacial side reactions. Therefore, the symmetrical cell exhibits an ultra-long cycling life of 4660 h at 5 mA cm −2 and 1 mAh cm −2 , and maintains stable operation up to 5050 h at 10 mA cm −2 . The Zn||I 2 full battery maintains 87.75% of its initial capacity after 8000 cycles at 10C. Furthermore, the stacked Zn||I 2 pouch battery provides an Ah-level capacity (1.64 Ah). This work provides a new insight into the construction of highly stable interfacial chemistry.}, archive = {J_ADVS}, author = {Xinyao Yuan and Di Zhang and Hongfei Lu and Yuhang Song and Zhiyi Du and Minjie Song and Nawei Lyu and Yang Jin}, doi = {10.1002/advs.202506035}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e06035}, shortjournal = {Adv. Sci.}, title = {Synergistic enhancement effect of maxwell polarization and preferential exposure of zn (101) plane toward superhydrophobic separator for ah-level zinc metal pouch batteries}, volume = {12}, year = {2025}, }
• (2025). Mixed-potential-driven catalysis: An electrochemical mechanism for room-temperature CO oxidation on gold catalysts. ADVS, 12(35), e05994. (www)

  @article{ , abstract = {Gold is an effective catalyst for low-temperature CO oxidation, yet its mechanism remains debated. Among the various proposed mechanisms, increasing attention has been given to a possible electrochemical pathway in recent studies. Here, experimental evidence is reported that CO oxidation at room temperature in electrolytes proceeds via coupled electrochemical CO oxidation and oxygen reduction half-reactions, i.e., the mixed-potential-driven mechanism. A model system is designed with deposited Au nanoparticles (NPs) and nitrogen-doped reduced graphene oxide (NrGO) on carbon paper acting as spatially separated electrodes in a single electrolysis cell. After shorting the two electrodes, the reaction current and mixed potential of the overall CO oxidation are measured without any externally applied bias. Independent current–potential curves for each half-reaction are also obtained under identical experimental conditions. The intersection points of these curves, representing the predicted mixed potential and net current, showed good agreement with the values measured in the short-circuited system. These results provide clear evidence that CO oxidation in aqueous media proceeds via a mixed-potential-driven mechanism, analogous to corrosion. This finding provides strong support for the hypothesis that low-temperature CO oxidation over-supported Au catalysts in the presence of water vapor proceeds via a similar electrochemical pathway in gas-phase heterogeneous catalysis.}, archive = {J_ADVS}, author = {Mo Yan and Muhammad Asif and Ravi Singh and Kotaro Takeyasu and Junji Nakamura}, doi = {10.1002/advs.202505994}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05994}, shortjournal = {Adv. Sci.}, title = {Mixed-potential-driven catalysis: An electrochemical mechanism for room-temperature CO oxidation on gold catalysts}, volume = {12}, year = {2025}, }
• (2025). Healable dielectric elastomer actuator with premature breakdown warning function for information transmission encryption and human-machine interaction. ADVS, 12(35), e05829. (www)

  @article{ , abstract = {Dielectric elastomer actuators (DEAs), regarded as artificial muscles, are used as actuators or sensors in artificial visual systems, haptic equipment, and human-robot interaction. However, their inherent vulnerability related to mechanical damage and electrical breakdown seriously limits their safe and long-term service. Herein, a healable dielectric elastomer (PHT-ZnS:Cu) is acquired for premature breakdown warning by synthesising a healable poly(dimethylsiloxane) based on reversible imine bonding and hydrogen bonding and subsequent incorporation of electroluminescent ZnS:Cu particles. Moreover, LiTFSI ionic liquids are introduced into the healable poly(dimethylsiloxane) to prepare a transparent healable compliant electrode (PHT-IL) that does not obscure the light emission of PHT-ZnS:Cu dielectric elastomer. Then, an integral healable DEA (ISDEA) with an excellent interfacial interaction is constructed by coating two sides of PHT-ZnS:Cu with PHT-IL. The optimized ISDEA displays an actuated strain of 17.0% at 15 kV mm −1 with a healing efficiency of 91.9%. The integrated ISDEAs are used as soft anti-counterfeiting labels and soft intelligent keyboards for information transmission, encryption, and human-machine interaction, showing prospective applications in the realm of data leakage prevention and personal privacy protection.}, archive = {J_ADVS}, author = {Yanze Liu and Shilin Luo and Jiawei Zhao and Lei Xu and Zhong-Zhen Yu and Dan Yang}, doi = {10.1002/advs.202505829}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05829}, shortjournal = {Adv. Sci.}, title = {Healable dielectric elastomer actuator with premature breakdown warning function for information transmission encryption and human-machine interaction}, volume = {12}, year = {2025}, }
• (2025). Metamorphosis from quantum dots to quantum shells and highly efficient quantum shell Light–Emitting diodes. ADVS, 12(35), e05737. (www)

  @article{ , abstract = {The bottom-up design of chemical structure affords 0D nanocrystals (NCs) with tunable band structures and unexpected optical properties. Herein, an example of alloyed quantum shell (QS) is demonstrated by tailoring the chemical compositions in its core/shell structure. In the CdZnSe/ZnSeS/CdSeS/CdS (C/S 1 /S 2 /S 3 , in which C is the CdZnSe core and S represents the shells) structure, there is an intriguing metamorphosis from quantum dot (QD) to QS (that is, C and C/S 1 belong to QDs, meanwhile C/S 1 /S 2 and C/S 1 /S 2 /S 3 are in the QS regime). Due to uniform morphology, perfect nanostructure, negligible defects, and unique energy level alignment, the C/S 1 /S 2 /S 3 QS exhibits a high photoluminescence quantum yield of 90.9%, an ultra-long fluorescence lifetime of 215.2 ns, and a slow radiative transition rate. It enables QS-based light–emitting diodes (QS-LEDs) with the state-of-the-art performance, such as high external quantum efficiency (EQE of 22.16%) and excellent stability. Meanwhile, the investigation of charge carrier dynamics reveals the difference between the QD- and QS-LEDs, showing that the charge carriers inside the QS-LEDs need more time to recombine with each other. Based on these findings, this study believes that the emerging QSs can be attractive and efficient light–emitting materials used in lighting and displays.}, archive = {J_ADVS}, author = {Zhao Chen and Xiaohan Chen and Yuan Xiao and Shuming Ren and Yang Li}, doi = {10.1002/advs.202505737}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05737}, shortjournal = {Adv. Sci.}, title = {Metamorphosis from quantum dots to quantum shells and highly efficient quantum shell Light–Emitting diodes}, volume = {12}, year = {2025}, }
• (2025). YTHDC1 is essential for postnatal liver development and homeostasis. ADVS, 12(35), e05725. (www)

  @article{ , abstract = {Hepatocytes play a crucial role in liver function, with their maturation occurring during postnatal development. However, the molecular mechanisms underlying this maturation are not yet fully understood. In this study, YTHDC1 is identified as a key positive regulator of hepatocyte maturation and an essential factor in maintaining liver homeostasis. YTHDC1 expression increases in the liver after birth, and hepatocyte-specific deletion of Ythdc1 impairs hepatocyte maturation, leading to reduced liver weight, liver injury, inflammation, and fibrosis. These defects contribute to the development of nonalcoholic steatohepatitis and hepatocellular carcinoma in mice. YTHDC1 supports postnatal hepatocyte maturation and liver function by enhancing the expression of key transcription factors, FOXA1 and FOXA2, at the posttranscriptional level through m 6 A recognition. Restoring FOXA1 or FOXA2 expression mitigates the phenotypic defects observed in Ythdc1 -HKO mice. Mechanistically, YTHDC1 binds to the m 6 A regions of Foxa1 and Foxa2 mRNAs, promoting their expression. These findings reveal a mechanism by which YTHDC1 regulates hepatocyte maturation.}, archive = {J_ADVS}, author = {Xinzhi Li and Xueying Li and Chunhong Liu and Zhenzhi Li and Kaixin Ding and Yuxin Wang and Ning Gu and Liwei Xie and Zheng Chen}, doi = {10.1002/advs.202505725}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05725}, shortjournal = {Adv. Sci.}, title = {YTHDC1 is essential for postnatal liver development and homeostasis}, volume = {12}, year = {2025}, }
• (2025). Monitoring the dynamics of alzheimer's disease biomarkers and the APOE–Tau axis via human cerebral organoids with immuno-SERS. ADVS, 12(35), e05660. (www)

  @article{ , abstract = {Noninvasive monitoring of Alzheimer's disease (AD) biomarkers is essential for early diagnosis and treatment efficacy. However, noninvasive monitoring of tau protein secretion, a key biomarker of AD, across developmental stages, age-related variations, and the interaction between apolipoprotein E ( APOE ) and the tau protein axis is not yet accomplished. Here, the label-free and non-invasive detection of multiple tau variants dynamics across developmental stages, age-related variants, and various APOE isogenic genotyes is presented to investigate the APOE –tau axis using human cerebral organoids (hCOs) combined with surface-enhanced Raman spectroscopy (SERS). Principal component analysis (PCA) of SERS signals successfully identifies four developmental stages of hCOs: embryonic body, neuronal differentiation, maturation, and maintenance phases. Temporal dynamics of age-related tau protein secretion are observed, reflecting characteristics associated with AD, which are diminished by astrocyte expression. PCA-based dimensionality reduction of SERS signals further reveals distinct clustering for different APOE isogenic genotypes, with tau protein secretion increasing from APOE2/E2 to APOE4/E4 , providing direct insight into the APOE –tau axis in AD. This study introduces a novel method for the non-invasive clinical assessments of disease conditions, dynamics, and the relationship between APOE and tau in AD.}, archive = {J_ADVS}, author = {Yongjae Jo and Youngjun Kim and Rian Kang and Seho Lee and Dang Du Nguyen and Soomin Park and Dongjoon Lee and Jong Won Han and Inhee Mook-Jung and Luke P. Lee and Jong-Chan Park and Inki Kim}, doi = {10.1002/advs.202505660}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05660}, shortjournal = {Adv. Sci.}, title = {Monitoring the dynamics of alzheimer's disease biomarkers and the APOE–Tau axis via human cerebral organoids with immuno-SERS}, volume = {12}, year = {2025}, }
• (2025). The long noncoding RNA ΒFaar promotes white adipose tissue browning and prevents diet-induced obesity. ADVS, 12(35), e05545. (www)

  @article{ , abstract = {The conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) is a promising strategy for obesity treatment. It is previously identified βFaar as a conserved long noncoding RNA (lncRNA) regulator of islet β-cell function in individuals with obesity, but its effect on WAT browning is not well understood. In this study, it is discovered that βFaar expression in adipose tissue markedly decreases with the progression of obesity in both mice and humans. βFaar in adipose tissue reduces lipid droplet (LD) size in WAT and promotes a browning phenotype in inguinal WAT (iWAT), leading to the amelioration of high-fat diet (HFD)-induced obesity. These effects can be attributed to crosstalk between βFaar and proteins within the master regulatory pathways of LD formation and WAT browning, including RAS oncogene family 18 (RAB18) and interferon regulatory factor 4 (IRF4). Specifically, βFaar inhibits LD swelling by binding to RAB18 and promoting IRF4 nuclear translocation, increases uncoupling protein 1 (UCP1) transcription, and further induces iWAT browning by binding to karyopherin subunit alpha 6 (KPNA6). Together, these results demonstrate the critical roles of βFaar in regulating iWAT browning and preserving metabolic health; thus, βFaar may be a potential therapeutic target for management of obesity and related disorders.}, archive = {J_ADVS}, author = {Yue Yang and Bin Huang and Baixue Sha and Danni Gao and Yimeng Qin and Ziyi Li and Xi Chen and Yinuo Jin and Yi Pan and Yanfeng Zhang and Yumeng Shen and Yu Liu and Liang Jin and Fangfang Zhang}, doi = {10.1002/advs.202505545}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05545}, shortjournal = {Adv. Sci.}, title = {The long noncoding RNA ΒFaar promotes white adipose tissue browning and prevents diet-induced obesity}, volume = {12}, year = {2025}, }
• (2025). Genetic manipulation of mammalian cells in microphysiological hydrogels. ADVS, 12(35), e05474. (www)

  @article{ , abstract = {Engineering functional 3D tissue constructs is essential for developing advanced organ-like systems, with applications ranging from fundamental biological research to drug testing. The generation of complex multicellular structures requires the integration of external geometric and mechanical cues with the ability to activate genetic programs that regulate and stimulate cellular self-organization. Here, it is demonstrated that gelatin methacryloyl (GelMA) hydrogels serve as effective matrices for 3D cell culture, supporting both in situ genetic manipulation and cell growth. HEK293T cells embedded in GelMA remained viable and proliferated over 16 days, forming clusters within the matrix. Efficient gene delivery is achieved in the 3D hydrogel environment using both plasmid DNA and mRNA as gene vectors. Furthermore, in situ prime editing is applied to induce permanent genetic modifications in embedded cells. To achieve spatially confined gene expression, gel-embedded channels are introduced that allowed localized stimulation via doxycycline perfusion through a Tet-On system. These findings demonstrate the feasibility of integrating gene delivery, inducible expression, and spatial control within GelMA-based hydrogels, establishing a versatile framework for engineered 3D cell systems with programmable genetic activity.}, archive = {J_ADVS}, author = {Anna C. Jäkel and Dong-Jiunn Jeffery Truong and Friedrich C. Simmel}, doi = {10.1002/advs.202505474}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05474}, shortjournal = {Adv. Sci.}, title = {Genetic manipulation of mammalian cells in microphysiological hydrogels}, volume = {12}, year = {2025}, }
• (2025). An innovative approach to precisely tailor the composition of syngas in CO2 electroreduction. ADVS, 12(35), e05424. (www)

  @article{ , abstract = {Syngas production through CO 2 electrochemical reduction reaction (CO 2 RR) has attracted numerous attention for reducing carbon emissions and increasing chemical feedstocks. However, the precise regulation of H 2 /CO molar ratio in syngas remains a challenge, especially through simple and feasible methodologies. In this work, a novel composite electrocatalyst, copper-indium/black phosphorus ( CuIn/BP ) is developed, using a simple one-step co-reduction method for efficient CO 2 RR. It is found for the first time that there is a linear relationship between BP content in CuIn/BP and the H 2 /CO molar ratio in syngas. Consequently, the H 2 /CO molar ratio in syngas can be precisely tailored by simply adjusting the BP content in CuIn/BP . A total faradaic efficiency (FE) of CO and H 2 reached ≈ 100% along with a current density of 135.2 mA cm −2 . Mechanistic studies suggest that the CuIn phase and Cu 3 P species are in situ generated in CuIn/BP , where the CuIn phases mainly contribute to CO generation, while the Cu 3 P species promote H 2 formation. The variation in BP content modulates the proportion of the CuIn phase and Cu 3 P species, leading to the variations in H 2 /CO molar ratios. Thus, this study provides an efficient and simple strategy to tailor the H 2 /CO molar ratio in syngas for various industrial applications.}, archive = {J_ADVS}, author = {Shuai Lv and Xinyi Sun and Baolin Wang and Wenrui Wan and Li Wang and Jianji Wang and Jinglai Zhang}, doi = {10.1002/advs.202505424}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05424}, shortjournal = {Adv. Sci.}, title = {An innovative approach to precisely tailor the composition of syngas in CO2 electroreduction}, volume = {12}, year = {2025}, }
• (2025). Si decoration tuning the electrocatalytic activity of ru via turing pattern design. ADVS, 12(35), e05418. (www)

  @article{ , abstract = {Green hydrogen, produced via renewable-energy-driven water electrolysis, is among the most promising new energy carriers. Ru is a potential catalyst for this purpose; however, its strong hydrogen binding strength results in poor reaction kinetics, limiting its application potential. Creating a new Ru structure by introducing a second element is crucial for optimizing its catalytic performance. However, only a few studies have explored this approach, leaving the understanding of how chemical composition influences Ru's structure and catalytic activity elusive. Here, a systematic study is reported on Si decoration of Ru, achieving a tunable local environment around Ru and optimized reaction kinetics. By constructing a Ru-SiO x interleaved Turing-patterned structure, the ratio of Si coordinated to Ru is tuned by well-designed selective etching. With increasing Si content, the H-binding strength on the Ru center is progressively weakened, resulting in a V-shaped trend in hydrogen production activity. The optimized sample exhibits a low overpotential of 21 mV at 10 mA cm −2 in alkaline solution, along with a Tafel slope of 40 mV dec −1 , surpassing the performance of commercial Pt/C. This study establishes a valuable framework for optimizing the surface properties and catalytic activity of noble metals.}, archive = {J_ADVS}, author = {Chuanlong Liu and Wenfei Wang and Fangkun Sun and Xinmeng Hu and Zhilin Guo and Yijia Liu and Dongying Huang and Weizheng Cai and Guangfu Luo and Jiazhen Wu}, doi = {10.1002/advs.202505418}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05418}, shortjournal = {Adv. Sci.}, title = {Si decoration tuning the electrocatalytic activity of ru via turing pattern design}, volume = {12}, year = {2025}, }
• (2025). Phenylalanine-based DNA-encoded chemical libraries for the discovery of potent and selective small organic ligands against markers of cancer and immune cells. ADVS, 12(35), e05351. (www)

  @article{ , abstract = {DNA-encoded chemical libraries (DELs) are powerful tools for drug discovery, enabling the high-throughput screening of vast libraries of small molecules against target proteins of pharmaceutical interest. Here, the synthesis of two new DELs, named FM-DEL1 and FM-DEL2, including 7′710 and 5′697’690 compounds, respectively is described. These libraries are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM-DELs are screened against markers of prostate cancer, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells. Highly potent and selective binders with affinity constants in the nanomolar range are obtained from DEL screenings against those targets. Small-molecule ligands against tumor-associated antigens are used to develop small-molecule radiopharmaceuticals that selectively accumulate at cancer sites after systemic administration.}, archive = {J_ADVS}, author = {Francesca Migliorini and Andrea Ciamarone and Sheila Dakhel Plaza and Tony Georgiev and Marta Mascellani and Emanuela Sabato and Giulio Vistoli and Ilaria Biancofiore and Nicholas Favalli and Emanuele Puca and Sebastian Oehler and Dario Neri and Samuele Cazzamalli}, doi = {10.1002/advs.202505351}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05351}, shortjournal = {Adv. Sci.}, title = {Phenylalanine-based DNA-encoded chemical libraries for the discovery of potent and selective small organic ligands against markers of cancer and immune cells}, volume = {12}, year = {2025}, }
• (2025). Determination of the kinetic rates and intrinsic nonradiative losses in organic thermally activated delayed fluorescence emitters. ADVS, 12(35), e05338. (www)

  @article{ , abstract = {Knowledge of kinetic rates of intersystem crossing (ISC) k ISC , reverse ISC k rISC , singlet k S , and triplet k T relaxation processes, respectively, is indispensable for material design as well as understanding of the operation of organic light-emitting diodes (OLEDs) based on organic emitters with thermally activated delayed fluorescence (TADF). Typically, the various rate constants are obtained by numerically fitting of the photoluminescence (PL) decay, but it is overlooked whether or not the solution of such a fit is unique. Using an analytical model, it is demonstrated that for typical TADF emitters only the sum of k S and k ISC , and the sum of k T and k rISC can be uniquely obtained from the transient PL decay and PL quantum yield (PLQY) experiments. Depending whether nonradiative losses stem from singlets or triplets, various combinations of k T and k rISC , k S and k ISC can be used to obtain the same transient PL decay, while keeping the PLQY constant. The only exception is the case of unity PLQY that allows for a direct determination of all relevant kinetic rates from just a single transient PL measurement. It is further shown that additional PL measurements in oxygen atmosphere with complete triplet quenching are redundant, since the results can be explicitly predicted from PL measurements in inert atmosphere. Using the TADF emitter CzDBA with a PLQY as high as 90% as a model system, it is demonstrated that by a combination of PL decay, PLQY, and OLED device modeling it is possible to quantify all the individual kinetic rates. For CzDBA neat film with PLQY as high as 90%, the majority of nonradiative losses stems from triplets, showing it is vital to conduct comprehensive studies on the molecular origin of nonradiative losses in the future.}, archive = {J_ADVS}, author = {Xin Zhou and Jawid Nikan and Kaiwen Guo and Paul W. M. Blom and Gert-Jan A. H. Wetzelaer and Yungui Li}, doi = {10.1002/advs.202505338}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05338}, shortjournal = {Adv. Sci.}, title = {Determination of the kinetic rates and intrinsic nonradiative losses in organic thermally activated delayed fluorescence emitters}, volume = {12}, year = {2025}, }
• (2025). Split-standing molecular engineering for textured Silicon/Perovskite tandems. ADVS, 12(35), e05288. (www)

  @article{ , abstract = {To effectively minimize reflection losses and achieve compatibility with industrial-scale silicon production lines, textured silicon/perovskite tandem solar cells have garnered significant attention in recent research. However, achieving uniform and stable coverage of the textured silicon substrate with hole-selective layer (HSL) remains a significant challenge. Herein, a HSL material, DPAICz ((indolo[2,3-a]carbazole-11,12-diylbis(ethane-2,1-diyl))bis(phosphonic acid)), is reported specifically designed for textured silicon substrate. Compared to the typical HSL material 2PACz, DPAICz features a π-expanded conjugated core and multiple anchoring groups, forming a split-standing configuration with anchoring groups positioned on opposite sides, resulting in superior anchoring stability on textured substrate under external stimuli. Moreover, DPAICz exhibited a larger molecular dipole moment and a more pronounced p-type characteristic, enhancing the interfacial hole extraction efficiency. Consequently, wide-bandgap (1.68 eV) perovskite solar cells employing DPAICz as the HSL achieved a champion power conversion efficiency (PCE) of 23.42%. Introducing the DPAICz into monolithic silicon/perovskite tandem solar cells greatly improved their performance, achieving a remarkable PCE of 32.55% in 1 cm 2 area. Importantly, the unencapsulated tandems based on DPAICz exhibited significantly enhanced long-term operational stability, retaining 96% of its initial PCE after 880 h of continuous 1-sun light soaking at 45 °C under open-circuit condition.}, archive = {J_ADVS}, author = {Xiaonan Wang and Yuan Tian and Libing Yao and Shaochen Zhang and Qingqing Liu and Ke Zhao and Jiazhe Xu and Jingjing Zhou and Caner Deger and Ilhan Yavuz and Jingjing Xue and Rui Wang}, doi = {10.1002/advs.202505288}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05288}, shortjournal = {Adv. Sci.}, title = {Split-standing molecular engineering for textured Silicon/Perovskite tandems}, volume = {12}, year = {2025}, }
• (2025). Unveiling the fundamental principles of reconfigurable resistance states in Silver/Poly(Ethylene glycol) nanofluids. ADVS, 12(35), e05103. (www)

  @article{ , abstract = {Developing novel memristive systems aims to implement key principles of biological neuron assemblies – plasticity, adaptivity, and self-organization – into artificial devices for parallel, energy-efficient computing. Solid-state memristive devices, such as crossbar arrays and percolated nanoparticle (NP) networks, already demonstrate these properties. However, closer similarity to neural networks is expected from liquid-state systems, including polymer melts, which remain largely unexplored. Here, the resistive switching in silver/poly(ethylene glycol) (Ag/PEG) nanofluids, prepared by depositing gas-aggregated Ag NPs into PEGs of varying molecular mass, is investigated. These systems form long-range conductive NP bridges with reconfigurable resistance states in response to an electric field. The zeta-potential of Ag NPs and molecular mobility of PEG determine the prevalence of low resistance (ohmic) state, high resistance states (poor conductance) or intermediate transition states governed by space-charge-limited conduction or electron tunneling. The occurrence of these states is given by the interparticle gaps, which are determined by the conformation of PEG molecules adsorbed on the NPs. It is presented, for the first time, an equivalent circuit model for the Ag/PEG system. These findings pave the way to adopt polymer melts as matrices for neuromorphic engineering and bio-inspired electronics.}, archive = {J_ADVS}, author = {Daniil Nikitin and Kateryna Biliak and Mariia Protsak and Blessing Adejube and Suren Ali-Ogly and Kateřina Škorvanková and Veronika Červenková and Ronaldo Katuta and Marco Tosca and Jan Hanuš and Zulfiya Černochová and Peter Černoch and Petr Štěpánek and Oleksandr Boiko and Paulina Szymoniak and Andreas Schönhals and Franz Faupel and Hynek Biederman and Alexander Vahl and Andrei Choukourov}, doi = {10.1002/advs.202505103}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05103}, shortjournal = {Adv. Sci.}, title = {Unveiling the fundamental principles of reconfigurable resistance states in Silver/Poly(Ethylene glycol) nanofluids}, volume = {12}, year = {2025}, }
• (2025). Pressure-induced metallization and isostructural transitions in 3R-MoS2. ADVS, 12(35), e05031. (www)

  @article{ , abstract = {At ambient conditions 3R-polytypes of transition metal dichalcogenides (TMDs) demonstrate fascinating properties because of their unique layer stacking. Understanding the structure-property relationship is essential for the realization of their use in spintronic, valleytronic, and optoelectronic applications. Herein, after the high pressure-temperature synthesis of 3R-MoS 2 in a large volume cubic press, a concomitant experimental and theoretical high-pressure study of 3R-MoS 2 is reported, leading to the discovery of pressure-induced reversible isostructural phase transitions without symmetry breaking. Concurrent with the isostructural transitions, a semiconductor-to-metal transition is observed, owing to strong interlayer interaction and charge redistribution across the van der Waals gap under pressure. The pressure-induced enhancement of interlayer interactions together with the robust intrinsic layer stacking in 3R-MoS 2 prevent the layers from sliding under pressure and hinder a corresponding volume collapse. This study on continuous pressure-tuning of crystal and electronic structure in 3R-MoS 2 will play a vital role in developing the next-generation devices involving coupling of structural, optical, and electrical properties of 3R-polytypes of TMDs and other layered materials.}, archive = {J_ADVS}, author = {Azkar Saeed Ahmad and Mangladeep Bhullar and Kenny Stahl and Wenting Lu and Taiyi Chen and Lei Feng and Xin Hu and Qian Zhang and Konstantin Glazyrin and Martin Kunz and Yusheng Zhao and Shanmin Wang and Yansun Yao and Elissaios Stavrou}, doi = {10.1002/advs.202505031}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e05031}, shortjournal = {Adv. Sci.}, title = {Pressure-induced metallization and isostructural transitions in 3R-MoS2}, volume = {12}, year = {2025}, }
• (2025). Immunocompatible elastomer with enhanced fibrous capsule-resistance and elasticity by water-induced surface phase reconfiguration.. ADVS, 12(35), e04801. (www)

  @article{ , abstract = {Integrating surface and bulk heterogeneity enables synergistic optimization of implantable biomaterials, harmonizing surface-tissue interactions with the mechanical integrity of the bulk. However, achieving this heterogeneity within a single material remains a significant challenge. Here, a strategy to engineer spontaneously generated heterogeneous surface and bulk structures within a material is introduced. The resulting material is termed phase-separation and underwater reconfiguration-enhanced (PURE) elastomers. PURE elastomers integrate the high elasticity of the bulk with superior immunocompatibility at the surface. By de novo designing the immunomodulatory and alkyl acrylate monomer structures, this is regulated that the copolymer's spatial configurations, ultimately influencing its condensed structure. Tuning the alkyl side chain length facilitates the formation of a distinctive phase-separation pattern in elastomers that accommodates large deformations, resulting in excellent toughness and low hysteresis. Moreover, this phase structure supports a water-induced surface phase reconfiguration, aligning with in vivo applications. This reconfiguration enriches immunomodulatory groups at the material surface, significantly enhancing immunocompatibility. Consequently, these elastomers exhibit extremely low fibrotic capsule formation for up to one year in mice and two months in non-human primates. This findings introduce a class of durable, fibrosis-resistant materials and establish a new strategy for designing heterogeneous polymeric elastomers with broad biomedical applicability.}, archive = {J_ADVS}, author = {Xianchi Zhou and Wenzhong Cao and Weifeng Liu and Wenbin Dai and Zihao Zhu and Fan Jia and Haijie Han and Ke Yao and Youxiang Wang and Jian Ji and Peng Zhang}, doi = {10.1002/advs.202504801}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04801}, shortjournal = {Adv. Sci.}, title = {Immunocompatible elastomer with enhanced fibrous capsule-resistance and elasticity by water-induced surface phase reconfiguration.}, volume = {12}, year = {2025}, }
• (2025). FemXpress: Systematic analysis of x chromosome inactivation heterogeneity in female single-cell RNA-seq samples. ADVS, 12(35), e04754. (www)

  @article{ , abstract = {X chromosome inactivation (XCI) is crucial for balancing X-linked gene dosage in female cells by randomly silencing one X chromosome during early embryogenesis. However, accurately classifying cells based on the parental origin of the inactivated X chromosome in single-cell samples remains challenging. Here we present FemXpress, a computational tool leveraging X-linked single nucleotide polymorphisms (SNPs) to group cells based on the origin of the inactivated X chromosome in female single-cell RNA sequencing (scRNA-Seq) data. FemXpress performs robustly on both simulated and real datasets, without requiring parental genomic information, and can also identify genes that escape XCI. Applying FemXpress to single-cell RNA-Seq data from multiple tissues of a cynomolgus monkey, we reveal heterogeneity in XCI origin across organs and cell types. In each organ, we identify candidate XCI-escaping genes, and within each cell type, we observe gene expression differences associated with XCI origin, potentially contributing to phenotypic variability. Furthermore, FemXpress demonstrated strong performance in phasing XCI in scRNA-Seq datasets from embryos and colon tumors. In summary, FemXpress provides a powerful approach for XCI status analysis, offering new insights into XCI dynamics at single-cell resolution.}, archive = {J_ADVS}, author = {Xin Wang and Yingke Ma and Fan Li and Wentao Cui and Tianshi Pan and Siqi Wang and Sinan Ma and Qingtong Shan and Chao Liu and Yukai Wang and Ying Zhang and Yuanchun Zhou and Wei Li and Pengfei Wang and Qi Zhou and Guihai Feng}, doi = {10.1002/advs.202504754}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04754}, shortjournal = {Adv. Sci.}, title = {FemXpress: Systematic analysis of x chromosome inactivation heterogeneity in female single-cell RNA-seq samples}, volume = {12}, year = {2025}, }
• (2025). Armoring boron nitride with pyrolytic carbon layers for tunable rigidity and flexibility. ADVS, 12(35), e04649. (www)

  @article{ , abstract = {Ceramic aerogels are acclaimed as ideal materials for extreme environments due to their ultrahigh porosity, low density, and exceptional thermal stability. However, the practical application of traditional ceramic aerogels is constrained by their inherent mechanical brittleness. Herein, a strategy is proposed to customize mechanically tunable aerogels by armoring ceramic nanounits with pyrolytic carbon (PyC). The PyC encapsulating layers with various thicknesses are transformed into ductile tights or rigid armors, facilitating the mechanical customization of BN@PyC aerogel from superelasticity to rigidity across scales. Interestingly, the PyC armor imparts unique versatility to the aerogel, including flame retardancy, elastic response conductivity, and thermal conductivity. Furthermore, owing to the thermal stability of the PyC armor, the BN@PyC aerogel maintains its mechanical integrity even after high-temperature thermal treatment, and exhibits an unexpected resistance to butane torch ablation. Integrating mechanical stability, high-temperature resistance, and multifunctionality, BN@PyC aerogels offer new possibilities for scalable applications in extreme environments. This facile strategy of armoring brittle ceramic aerogels with PyC provides a novel reference for customizing the mechanical properties of multifunctional aerogels.}, archive = {J_ADVS}, author = {Meng Lan and Yu Pei and Kexin Huang and Yudong Zhou and Xiao Han and Qiangang Fu}, doi = {10.1002/advs.202504649}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04649}, shortjournal = {Adv. Sci.}, title = {Armoring boron nitride with pyrolytic carbon layers for tunable rigidity and flexibility}, volume = {12}, year = {2025}, }
• (2025). Fast charging and high power ionogel-based rain energy harvester. ADVS, 12(35), e04608. (www)

  @article{ , abstract = {The growing demand for sustainable energy has triggered the exploration of innovative solutions to harness clean and renewable sources. In this pursuit, harvesting rain energy has emerged as a promising approach due to its unlimited availability. However, traditional droplet-based harvesters face several challenges, including a long charging period, low electrical power output, and fast charge dissipation. This study presents an innovative ionogel-based rain energy harvester that overcomes these limitations. The key advancement lies in the stable polarized interface created by the ionogel, which enables rapid charging and high charge retention, leading to a significant instantaneous power within the first few raindrops and achieving an 8-fold increase in saturation performance over conventional design. The harvester only requires 25 droplets to reach saturation and maximum electrical output, achieving an impressive power density of 235.11 W m −2 and a conversion efficiency of 6.77%, being the highest recorded for ionogel and hydrogel-based droplet energy harvesters. Additionally, the adhesive nature of the ionogel enhances the device's stability and versatility in varying energy generation and steam leakage applications. This work advances the pursuit of sustainable energy harvesting by bridging materials science with practical application.}, archive = {J_ADVS}, author = {Ruoxuan Ye and Irum Firdous and Muhammad Fahim and Jihong Shi and Weilu Li and Xiangkun Bo and Fei Lui and Walid A. Daoud}, doi = {10.1002/advs.202504608}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04608}, shortjournal = {Adv. Sci.}, title = {Fast charging and high power ionogel-based rain energy harvester}, volume = {12}, year = {2025}, }
• (2025). Metal-ligand complexes as multifunctional platforms for photo-activated cancer therapy. ADVS, 12(35), e04575. (www)

  @article{ , abstract = {Metal-ligand complexes have emerged as versatile platforms for photo-activated therapy (PAT) for cancer, including photothermal therapy, photodynamic therapy, and photo-activated chemotherapy. This review explores the unique optical properties and tunable characteristics of these complexes, which enable effective reactive oxygen species generation and near-infrared light absorption for targeted cancer cell destruction. Metal-ligand complexes are classified based on their ligands and metal ions. The ligands include tetrapyrrolic structures, polypyridine, and polyphenols, while the metal ions comprise transition and noble metals. Their individual contributions to enhancing therapeutic efficacy are also explored. Fundamental interactions, including ligand-to-metal charge transfer and metal-ligand coordination, are examined. These interactions significantly influence the photoreactivity and biocompatibility of the complexes. Recent advances integrating metal-ligand complexes with other modalities, such as chemo-phototherapy and immunotherapy, are highlighted. These combinations offer promising approaches for synergistic tumor eradication. The challenges of ligand diversity, delivery optimization, and the underexplored mechanisms in PAT are also discussed. By integrating recent progress and prospective applications, this review emphasizes the critical importance of metal-ligand complexes in innovating cancer theranostic technologies.}, archive = {J_ADVS}, author = {Jeonga Kim and Saehan Choi and Yoonsung Nam}, doi = {10.1002/advs.202504575}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04575}, shortjournal = {Adv. Sci.}, title = {Metal-ligand complexes as multifunctional platforms for photo-activated cancer therapy}, volume = {12}, year = {2025}, }
• (2025). KRAS/ABHD17C/ALOX15B axis promotes pancreatic cancer progression via ferroptosis evasion. ADVS, 12(35), e04470. (www)

  @article{ , abstract = {Understanding the mechanisms underlying Kirsten rat sarcoma (KRAS) mutation-driven development and progression of pancreatic ductal adenocarcinoma (PDAC) may facilitate the discovery of novel strategies for KRAS-mutant PDAC (KRAS mut -PDAC) treatment. Here, it is reported that downregulation of arachidonate 15-lipoxygenase (ALOX15B) significantly correlated with poor outcomes in patients with KRAS mut -PDAC. Mechanistically, KRAS mut /ERK1-elicited phosphorylation of ABHD17C promotes depalmitoylation and membrane-to–cytoplasm translocation of ALOX15B, facilitating proteasome-dependent degradation of ALOX15B via interaction with the E3 ligase complex CUL4/DDB1/DCAF10. Notably, treatment with methyl protodioscin (MPD), a steroid saponin primarily purified from polygonatum sibiricum rhizome, restored the S-palmitoylation and membrane location of ALOX15B via disruption of the ABHD17C/ALOX15B interaction, consequently resulting in significant inhibition of growth rate of patient-derived KRAS mut -PDAC organoids in vitro and KRAS mut -PDAC-formed tumor in vivo via induction of ferroptosis. Therefore, these findings unveil a prominent role of ferroptosis evasion in KRAS mut -PDAC progression and highlight the potential of targeting KRAS/ERK1/ABHD17C/ALOX15B axis in KRAS mut -PDAC treatment.}, archive = {J_ADVS}, author = {Man Li and Xuexin Yu and Yuanji Liu and Shuqin Ouyang and Long Wu and Xiaohong Chen and Huiqi Yu and Haoming Chen and Senmao Lian and Ziwen Li and Liyun Gong and Libing Song and Jun Li}, doi = {10.1002/advs.202504470}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04470}, shortjournal = {Adv. Sci.}, title = {KRAS/ABHD17C/ALOX15B axis promotes pancreatic cancer progression via ferroptosis evasion}, volume = {12}, year = {2025}, }
• (2025). Wearable PEDOT:PSS/DVS-coated yarn-type transpiration-driven electrokinetic power generator with high power efficiency and water stability. ADVS, 12(35), e04463. (www)

  @article{ , abstract = {Hydrovoltaic nanogenerators, which harness small quantities of water to generate power, are gaining considerable attention for applications in next-generation wearable electronics. Conventional hydrovoltaic nanogenerators are constrained by their limited power density and suboptimal long-term stability. Therefore, a transpiration-driven electrokinetic power generator (TEPG) based on silk yarn coated with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/divinyl sulfone (DVS) and designed as a wearable hydrovoltaic nanogenerator offering outstanding power generation efficiency and water stability is presented in this study. Given its hydrophilic surface, mechanical durability, and high aspect ratio, silk yarn is used to design a yarn-based TEPG system to achieve high spatial-efficiency and maximize volumetric power density. Furthermore, the covalent crosslinking agent, DVS, is introduced to sustain the long-term, high-power production efficiency of PEDOT:PSS. The devised yarn-type TEPG system generates a maximum power of 112 µW cm −3 with artificial sweat. A system comprising 25 yarn-type TEPGs arranged in a series–parallel configuration is implemented utilizing the high spatial-efficiency of the sewable yarn-type TEPG. The results demonstrate the potential of wearable hydrovoltaic nanogenerators as next-generation renewable energy systems for wearable applications.}, archive = {J_ADVS}, author = {Hyungsub Yoon and Heebo Ha and Mintaek Hong and Seonghun Lee and Mathis Mortensen Brette and Ji-Won Jung and Ki Ro Yoon and Ergang Wang and Han Seul Kim and Byungil Hwang and Tae Gwang Yun}, doi = {10.1002/advs.202504463}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04463}, shortjournal = {Adv. Sci.}, title = {Wearable PEDOT:PSS/DVS-coated yarn-type transpiration-driven electrokinetic power generator with high power efficiency and water stability}, volume = {12}, year = {2025}, }
• (2025). Microstructural origin of nonmonotonic piezoresistivity in polymer nanocomposites. ADVS, 12(35), e04381. (www)

  @article{ , abstract = {Incorporating conductive nanomaterials into polymers yields a new class of piezoresistive strain-sensing materials. While possessing monotonic resistance-strain behavior is a fundamental requirement for any material used for strain sensing, polymer nanocomposites frequently exhibit nonmonotonic resistance responses under strain, which limits their application prospects. In this study, physical experiments and molecular dynamics simulations are performed to determine a feasible solution to overcome this limitation. The corresponding results demonstrate that regulating the initial inter-nanofiller junction geometry imparts complete control over the monotonic piezoresistive behavior of polymer nanocomposites. Mechanistically, monotonically increasing resistance responses under tension can be achieved by promoting active diffusion that causes van der Waals force-driven barrier crossing of nanofillers (resulting in direct contact between nanofillers, e.g., at elevated curing temperatures) during curing; thus, during deformation, nanofillers primarily move away from one another. Conversely, suppressing diffusion during curing causes barrier crossing of nanofillers, which results in resistance reduction, under deformation owing to stress-driven local rearrangement of polymer molecules in heterogeneous shear transformation zones. The mechanistic insights provided by this study can guide the design of next-generation, advanced strain-sensing materials in the future.}, archive = {J_ADVS}, author = {Ting Yui Wong and Kui Lin and Tao Yu and Fangxin Zou}, doi = {10.1002/advs.202504381}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04381}, shortjournal = {Adv. Sci.}, title = {Microstructural origin of nonmonotonic piezoresistivity in polymer nanocomposites}, volume = {12}, year = {2025}, }
• (2025). PRC1-mediated H2Aub loop formation and function in arabidopsis. ADVS, 12(35), e04377. (www)

  @article{ , abstract = {Polycomb group (PcG) complexes play a crucial role in the regulation of gene repression and in organizing the 3D conformation of chromatin. However, while Polycomb Repressive Complex (PRC) 2 mediated H3K27me3 clearly contributes to the formation of repressive chromatin loops in Arabidopsis , the role of PRC1 mediated H2Aub remains unclear. Notably, in the Arabidopsis genome, H2Aub and H3K27me3 marks do not always co-localize, and some regions are marked exclusively by H2Aub, but the contribution of these only-H2Aub regions to chromatin looping remains largely unexplored. By using Capture-High-throughput Chromosome Conformation Capture (C-Hi-C) to specifically enrich interactions associated with H2Aub regions, it is find that H2Aub loops are preferentially established between two H2Aub enriched regions. Although pure only-H2Aub-loops can be detected, H2Aub regions tend to interact with regions marked by both H2Aub and H3K27me3, contributing to the formation of PcG hubs. Furthermore, it is find that maintaining appropriate level of H2Aub and H3K27me3 is essential for the stability of H2Aub loops and that the formation of these loops reinforce gene repression. This findings unveil the existence of H2Aub loops in Arabidopsis and their impact on transcriptional regulation.}, archive = {J_ADVS}, author = {Lingxiao Luo and Minqi Yang and Zhihan Song and Yali Liu and Suxin Xiao and Dingyue Wang and Myriam Calonje and Hang He and Yue Zhou}, doi = {10.1002/advs.202504377}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04377}, shortjournal = {Adv. Sci.}, title = {PRC1-mediated H2Aub loop formation and function in arabidopsis}, volume = {12}, year = {2025}, }
• (2025). A systematic computational framework for practical identifiability analysis in mathematical models arising from biology. ADVS, 12(35), e04346. (www)

  @article{ , abstract = {Practical identifiability is a fundamental challenge in the data-driven modeling of biological systems, as many model parameters cannot be directly measured and must be estimated from experimental data. Without confirming the identifiability of these parameters, model predictions may be unreliable, limiting their usefulness for understanding biological mechanisms or informing experimental and clinical decisions. In this paper, a novel mathematical framework is proposed for practical identifiability analysis in dynamic models. Starting from a rigorous mathematical definition, it is proved that practical identifiability is equivalent to the invertibility of the Fisher Information Matrix (FIM). The relationship between practical identifiability and coordinate identifiability is further established, introducing an efficient metric that simplifies and accelerates identifiability assessment compared to traditional profile likelihood methods. To address non-identifiable parameters, new regularization terms are incorporated, enabling uncertainty quantification and improving model reliability. Additionally, an optimal experimental design algorithm is developed to ensure all parameters are practically identifiable from collected data. Applications to Hill functions, neural networks, and biological models demonstrate the effectiveness and computational efficiency of the proposed framework in uncovering critical biological processes and identifying key observable variables.}, archive = {J_ADVS}, author = {Shun Wang and Wenrui Hao}, doi = {10.1002/advs.202504346}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04346}, shortjournal = {Adv. Sci.}, title = {A systematic computational framework for practical identifiability analysis in mathematical models arising from biology}, volume = {12}, year = {2025}, }
• (2025). AntiBMPNN: Structure-guided graph neural networks for precision antibody engineering. ADVS, 12(35), e04278. (www)

  @article{ , abstract = {Antibodies are crucial for medical applications, yet traditional methods for designing sequences are inefficient. This study introduces AntiBMPNN, an advanced deep-learning framework that leverages an antibody-specific 3D dataset, a fine-tuned message-passing neural network (MPNN), a frequency-based scoring function, and AlphaFold 3 to achieve highly accurate antibody sequence design. AntiBMPNN surpasses ProteinMPNN with a perplexity of 1.5 and over 80% sequence recovery. Its scoring function, combined with AlphaFold 3, effectively prioritizes sequences based on structural recovery, positional stability, and biochemical or complex properties. Experimental validation highlights a 75% success rate in single-point antibody design. AntiBMPNN consistently outperforms AbMPNN, AntiFold, and ProteinMPNN in designing complementarity determining regions (CDR) 1-3, yielding stronger binding affinities. For CDR1 of huJ3 (anti-HIV nanobody), it achieves a half maximal effective concentration (EC₅₀) of 9.2 nM (nanomolar), better than ProteinMPNN (135.2 nM) and AntiFold (59.3 nM), and comparable to AbMPNN (6.6 nM). For CDR2 of the D6 nanobody (targeting CD16), AntiBMPNN reaches 0.3 nM, outperforming AbMPNN (2.3 nM), AntiFold (0.7 nM), and ProteinMPNN (0.7 nM). In CDR3 of huJ3, it achieves 1.7 nM, surpassing AbMPNN (51.2 nM), with no detectable activity from AntiFold or ProteinMPNN. These findings confirm that AntiBMPNN-designed sequences for J3 and D6 outperform the originals, highlighting its potential to improve therapeutic antibody design.}, archive = {J_ADVS}, author = {Ze-Yu Sun and Jiayi Yuan and Divya Jaiswal and Jingxuan Ge and Tianjian Liang and Jiahui Wei and Jinghong Cao and Yulong Li and Xiaojie Chu and Yan Chen and Ying Xue and Wei Li and Tingjun Hou and Zhiwei Feng}, doi = {10.1002/advs.202504278}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04278}, shortjournal = {Adv. Sci.}, title = {AntiBMPNN: Structure-guided graph neural networks for precision antibody engineering}, volume = {12}, year = {2025}, }
• (2025). Tuneable hydrogel porosity via dynamic tailoring of spinodal decomposition. ADVS, 12(35), e04265. (www)

  @article{ , abstract = {Pores within hydrogel structures play a crucial role in fostering cell growth and tissue development. The creation and control of pore size and interconnectivity can be conveniently achieved with aqueous two-phase emulsions. The decomposition of these emulsions into two separate phases can be controlled by carefully choosing the polymer components and solution conditions. Spinodal decomposition, a mechanism of phase separation, can result in a highly interconnected pore morphology, though controlling this process is difficult in practice, limiting its application for in vitro models. Here, a straightforward method is introduced for dynamically halting the phase separation of a gelatin methacryloyl and poly(vinyl alcohol) (GelMA-PVA) polymer blend in the context of a biofabrication process based on dynamic interface printing (DIP). This is enabled by a novel approach based on the concerted application of acoustic mixing and photocuring to structure the pore size, orientation, and interconnectivity in hydrogels. This approach accordingly enables spatially addressable fabrication of 3D hydrogel architectures, with the potential to enhance the functionality of engineered tissues via tailored microenvironments.}, archive = {J_ADVS}, author = {Michael Halwes and Callum Vidler and Lilith Caballero Aguilar and Farzaneh Taromian and David R Nisbet and Melanie Stamp and Khoon S. Lim and Andrea J. O'Connor and David J. Collins}, doi = {10.1002/advs.202504265}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04265}, shortjournal = {Adv. Sci.}, title = {Tuneable hydrogel porosity via dynamic tailoring of spinodal decomposition}, volume = {12}, year = {2025}, }
• (2025). Autophagy-mediated suppression of tumor growth by food-grade lipid nanoparticles in mice. ADVS, 12(35), e04220. (www)

  @article{ , abstract = {Food-grade lipid nanoparticles (FLNs) have been widely used as functional carriers of various nutrients and clinical drugs; however, the potential for FLNs to induce substantial biological effects is often overlooked. Here, it is found that FLNs are first delivered to the early endosomes and then preferentially fused with lipid droplets (LDs) after entering the cells through endocytosis. This process leads to a notable LDs accumulation, which in turn triggers autophagy via the AMPK-mTOR-ULK1 signaling pathway. The cascade ultimately promotes tumor cell growth and invasion. However, autophagy inhibition while FLNs treatment counteracts these effects and further causes mitochondria damage, increased reactive oxygen species (ROS) levels, and excessive LDs accumulation, eventually leading to cell apoptosis. This indicates a potential anti-tumor strategy. The animal tests further demonstrate that intratumoral injection of FLNs together with an autophagy inhibitor (3-MA) effectively suppresses tumor angiogenesis, proliferation, and metastasis without harming normal cells in mice, confirming a promising and safe anti-tumor strategy of applying FLNs under autophagy inhibition conditions. The findings represent a substantial step forward in comprehending the biological effects of biomedical carriers.}, archive = {J_ADVS}, author = {Chenglu Peng and Bing Jiang and Wei Lu and Przemyslaw Zalewski and Jun He and Xiaoyang Li and Yiping Cao and Yiguo Zhao and Cuixia Sun and Katsuyoshi Nishinari and Yapeng Fang}, doi = {10.1002/advs.202504220}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04220}, shortjournal = {Adv. Sci.}, title = {Autophagy-mediated suppression of tumor growth by food-grade lipid nanoparticles in mice}, volume = {12}, year = {2025}, }
• (2025). A novel nor@DHB matrix for direct microbial analysis in lung cancer tissues. ADVS, 12(35), e04038. (www)

  @article{ , abstract = {Dynamic changes occurring in the lung microbiota can impact the initiation, progression, and prognosis of lung cancer (LC). Consequently, the development of suitable intratumoral microbiota analysis methods is crucial. Although matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) involves straightforward operations and provides precise results, the “direct smear method” limits the identification of bacterial subspecies. Furthermore, the issue of inadequate quantification with MALDI MS renders it unsuitable for direct analysis of intratumoral bacteria. To address these challenges, a novel ionic liquid in this study is employed, called norharmane conjugated to 2,5-dihydroxybenzoic acid (Nor@DHB) for the direct detection of intratumoral bacteria using MALDI MS. Because gram-negative bacteria are dominant within cancer cells, lipid A is selected as the chemical fingerprint for bacterial identification. The results demonstrated that using Nor@DHB can enhance the lipid A signal by an order of magnitude and achieved a good linear relationship within a concentration range of 0.01–80 ng mL −1 . Here, this method is successfully applied to the direct analysis of lipid A in actual clinical samples. Subsequent machine learning and nomogram models further confirmed the correlation between characteristic lipid A ions and LC patient clinicopathological features, which are further validated through both in vitro and in vivo experiments.}, archive = {J_ADVS}, author = {Liang Shan and Xin Xu and Lin Huang and Dan Li and Yiran Deng and Xiangfei Xue and Susu Guo and Yiman Huang and Xiao Zhang and Yongchun Yu and Lifang Ma and Kun Qian and Jiayi Wang}, doi = {10.1002/advs.202504038}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04038}, shortjournal = {Adv. Sci.}, title = {A novel nor@DHB matrix for direct microbial analysis in lung cancer tissues}, volume = {12}, year = {2025}, }
• (2025). Macrophage derived galectin-3 promotes renal fibrosis and diabetic kidney disease by enhancing TGFβ1 signaling. ADVS, 12(35), e04032. (www)

  @article{ , abstract = {Over 30% of patients with type 2 diabetes develop diabetic kidney disease (DKD), which has emerged as a major contributor to end stage renal disease. Renal fibrosis represents the final pathological outcome of most chronic kidney disease, particularly DKD. This study demonstrates elevated levels of Galectin-3 (Gal3), a lectin associated with inflammatory and fibrotic conditions, in the plasma and kidneys of DKD mice. Positive correlations between Gal3 expression and renal fibrosis are observed in both DKD patients and mice. Macrophage-derived Gal3 is found to promote Transforming growth factor beta 1 (TGFβ1) signaling activation and renal fibrogenesis. Genetic ablation of Gal3 globally or specifically in macrophages, as well as pharmacological inhibition of Gal3, significantly attenuated kidney fibrosis in diabetic mice. Mechanistically, macrophage-derived Gal3 interacted with TGFβ receptor2 (TGFBR2) and Pro-TGFβ1, preventing TGFBR2 proteasomal degradation in fibroblasts and increasing TGFβ1 levels in the diabetic kidney. These events enhances TGFβ1 signaling activation and ultimately facilitated kidney fibrosis. The findings of this study suggest Gal3 as a potential therapeutic target for renal fibrosis and DKD.}, archive = {J_ADVS}, author = {Yibing Chen and Qian Jiang and Xiaowei Xing and Liu Xu and Qijin Zhao and Qidong Zhang and Jingwen Chen and Chunxiao Ma and Xingfeng Liu and Yinfei Lu and Yanjun Wan and Lijuan Kong and Shaocong Hou and Qian Lu and Bing Cui and Jiankan Guo and Hongdong Huang and Pingping Li}, doi = {10.1002/advs.202504032}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e04032}, shortjournal = {Adv. Sci.}, title = {Macrophage derived galectin-3 promotes renal fibrosis and diabetic kidney disease by enhancing TGFβ1 signaling}, volume = {12}, year = {2025}, }
• (2025). Sequence- and docking-site-dependent contributions to multi-site phosphorylation of an intrinsically disordered MAPK substrate. ADVS, 12(35), e03987. (www)

  @article{ , abstract = {Protein kinases often rely on docking site motifs to enhance substrate interactions and facilitate phosphorylation. For example, mitogen-activated protein kinases (MAPKs) utilize D- and F-motifs, which frequently act in concert to enable bipartite substrate binding. While these motifs are known to modulate phosphorylation efficiency, their quantitative impact on target site phosphorylation within long intrinsically disordered substrates remains largely unexplored. Using NMR spectroscopy, JNK1-dependent phosphorylation of JIP1, a 450-amino acid disordered substrate, is investigated, identifying eleven phosphosites with distinct phosphorylation efficiencies. By selectively disrupting JNK1 binding to the D- and F-motifs of JIP1, the determinants of phosphorylation efficiency are uncovered. Specifically, it is found that the D-motif selectively enhances phosphorylation in the C-terminal direction in a length-dependent manner, impressively increasing the phosphorylation efficiencies of sites located at sequence distances exceeding 120 amino acids, while the F-motif primarily promotes phosphorylation of a site located immediately N-terminal to the F-motif. Additionally, docking-site-independent phosphorylation is observed, whose efficiency is dictated by the intrinsic sequence preference of JNK1, as inferred from motif scores derived from positional scanning peptide arrays. The work highlights how docking site motifs and sequence context synergistically regulate phosphorylation efficiency, emphasizing the critical role of substrate architecture in determining MAPK-mediated signaling outcomes.}, archive = {J_ADVS}, author = {Thibault Orand and Elise Delaforge and Marion Chenal and Maud Tengo and Torsten Herrmann and Juan Cortés and Pau Bernadó and Malene Ringkjøbing Jensen}, doi = {10.1002/advs.202503987}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e03987}, shortjournal = {Adv. Sci.}, title = {Sequence- and docking-site-dependent contributions to multi-site phosphorylation of an intrinsically disordered MAPK substrate}, volume = {12}, year = {2025}, }
• (2025). Energy-efficient fabrication of biomimetic materials for sustainable infrastructure applications. ADVS, 12(35), e03854. (www)

  @article{ , abstract = {Despite significant advances in the synthesis of biomimetic materials, the scalable fabrication of high-performance bulk materials under ambient conditions remains a formidable challenge— particularly when it comes to achieving rapid processing while preserving superior mechanical properties. Herein, inspired by nacre's “brick-and-mortar” structure, this work develops an energy-efficient approach that utilizes ice-templating technology as the structure framework and carbon mineralization for rapid CaCO 3 production, resulting in a strong yet tough carbon mineralized material (CMM) while also fixing CO 2 . This material replicates both the hierarchical microstructure and chemical composition of nacre. By precisely controlling the freezing dynamics with dual temperature gradients, this work creates an ordered lamellar skeleton composed of γ-dicalcium silicate (γ-C 2 S). The rapid, in situ carbon mineralization under mild conditions generates interspersed CaCO 3 grains within this structure, which are then infiltrated with gelatin to form a nacre-like CMM with exceptional mechanical properties. The resulting material exhibits a flexural strength of 45 MPa (eight times that of a cement-hydrogel composite) and a fracture toughness of 2.03 MJ m −3 (a 20-fold improvement over unmodified CMM), while maintaining a density of only 1.2 g cm −3 . The enhanced performance stems from multiscale toughening mechanisms, including crack deflection, secondary crack formation, and strong interfacial bonding, all of which facilitate efficient energy dissipation. This work establishes a new paradigm for designing high-performance synthetic materials through the synergistic integration of biomimetic principles with carbon mineralization, offering promising applications in the development of sustainable infrastructure and carbon neutrality.}, archive = {J_ADVS}, author = {Jingze Chen and Zhichao Liu and Shujun Zhang and Shuguang Hu and Fazhou Wang}, doi = {10.1002/advs.202503854}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e03854}, shortjournal = {Adv. Sci.}, title = {Energy-efficient fabrication of biomimetic materials for sustainable infrastructure applications}, volume = {12}, year = {2025}, }
• (2025). Sustained-release photothermal microneedles for postoperative incisional analgesia and wound healing via hydrogen therapy. ADVS, 12(35), e03698. (www)

  @article{ , abstract = {Effective management of postoperative pain and wound healing presents significant challenges in clinical settings, driving the need for innovative therapeutic approaches. The analgesic and wound healing effects of hydrogen (H 2 ) have gradually been recognized; however, the lack of efficient hydrogen delivery systems remains a major limitation. This study introduces a novel transdermal drug delivery system, which utilizes sustained-release photothermal microneedles (MNs) to ameliorate incisional pain and accelerate wound healing. Polydopamine (PDA)-modified ZIF-8@ammonia borane (AB) nanoparticles with photothermal conversion properties are designed, along with temperature-responsive QX-314-loaded polycaprolactone (PCL) microspheres for controlled release, which are delivered in vivo by dissolvable MNs. In vitro results showed that PDA@ZIF-8@AB nanoparticles can release H 2 continuously for up to 5 days in an acidic microenvironment, while the photothermal properties of PDA facilitated controlled release of QX-314 through 6 cycles of near-infrared (NIR) exposure. In vivo experiments demonstrated that the MN system provided sustained analgesia for up to 5 days and promoted wound healing in the acidic microenvironment of postoperative incisions. Upon NIR exposure, the photothermal conversion of PDA activated membrane ion channels and induced thermally triggered deformation of PCL@QX-314 microspheres, allowing for on-demand release of QX-314 and targeted neuronal uptake, thus offering personalized analgesia. In vitro cell experiments and in vivo studies confirmed the biocompatibility of the system. This innovative approach not only highlights the dual role of H 2 in pain relief and wound healing but also provides a new personalized treatment strategy for postoperative pain management with promising clinical applications.}, archive = {J_ADVS}, author = {Aining Zhang and Xue Jiang and Bingrui Xiong and Jiayi Chen and Xin Liu and Siyuan Wang and Bofu Li and Mian Peng and Wei Li}, doi = {10.1002/advs.202503698}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e03698}, shortjournal = {Adv. Sci.}, title = {Sustained-release photothermal microneedles for postoperative incisional analgesia and wound healing via hydrogen therapy}, volume = {12}, year = {2025}, }
• (2025). Nanoscale metal-organic framework-based self-monitoring oxygen economizer and ROS amplifier for enhanced radiotherapy-radiodynamic therapy. ADVS, 12(35), e03582. (www)

  @article{ , abstract = {Radiotherapy-radiodynamic therapy (RT-RDT) has emerged as a promising approach due to its remarkable anticancer efficacy. However, hypoxic tumor microenvironment and insufficient energy deposition severely reduce the radiotherapy outcomes. Herein, lonidamine (LND)-loaded Fe(III) metal-Pt(II) porphyrin framework (FPTM-LP) is designed for radiosensitization through hypoxia alleviation and reactive oxygen species (ROS) amplification. Specifically, the high-Z element Pt effectively absorbs X-ray photons to generate •OH for RT while transferring X-ray energy to porphyrin (TCPP), which stimulates the generation of 1 O 2 for RDT. Moreover, by the inhibition of oxidative phosphorylation, the weak acidity and glutathione (GSH)-responsive release of LND achieves O 2 economization, which promotes the generation of ROS and stabilizes DNA damage. Intriguingly, Pt(II)TCPP exhibits the capability of O 2 concentration-dependent near infrared luminescence imaging-guided RT-RDT. Moreover, the decomposition of FPTM-LP under high concentration of GSH generates large amounts of Fe 2+ , leading to the augmented production of •OH via Fenton reactions. In brief, this work presents a radiosensitizer with a unique and efficient mechanism of self-monitoring hypoxia alleviation and increasing ROS levels for enhanced cancer RT-RDT. The radiosensitization potency of FPTM-LP is confirmed in tumor-bearing mice in vivo, proclaiming a new strategy for enhancing therapeutic efficacy and minimizing side effects.}, archive = {J_ADVS}, author = {Shiye Du and Qiang Wen and Ting Han and Jiongyu Ren and Mingyu Wang and Yunpeng Dai and Xiaoguang Ge and Lu Li and Junzhi Liu and Shi Gao}, doi = {10.1002/advs.202503582}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e03582}, shortjournal = {Adv. Sci.}, title = {Nanoscale metal-organic framework-based self-monitoring oxygen economizer and ROS amplifier for enhanced radiotherapy-radiodynamic therapy}, volume = {12}, year = {2025}, }
• (2025). Fabrication of dual photodynamic enhanced antimicrobial CDs@ZIF-8/Polycaprolactone/Ethyl cellulose nanofibrous films for fruit preservation. ADVS, 12(35), e03567. (www)

  @article{ , abstract = {Carbon dots (CDs) have elicited attention in photodynamic antimicrobial applications, but their susceptibility to aggregation limits their effectiveness. Herein, CDs@ZIF-8 nanocomposites are synthesized. The results reveal that they have superior dual photodynamic enhanced antimicrobial properties, specifically 7.63 log 10 CFU mL −1 (lg) elimination for Escherichia coli (only 3.12 lg with CDs and 4.18 lg with ZIF-8) and 7.27 lg elimination for Staphylococcus aureus (only 4.17 lg with CDs and 2.94 lg with ZIF-8). Optoelectronic property analysis and density functional theory calculations show that the enhanced photodynamic antimicrobial properties of CDs@ZIF-8 can be attributed to their narrow bandgap and higher binding affinity for O 2 , which facilitates the photo-generated e − –h + pairs separation and promotes the generation of 1 O 2 and •O 2 − . Furthermore, the CDs@ZIF-8/polycaprolactone/ethyl cellulose nanofibrous films are prepared by microfluidic-blow-spinning, which have prominent antimicrobial properties and extend the shelf life of strawberries from 6 to 12 d. Overall, this study provides a novel idea for designing synergistically enhanced photodynamic antimicrobial materials and photodynamic preservation of perishable fruits.}, archive = {J_ADVS}, author = {Yongrui Ti and Ziqiang Qin and Xiaohong Guo and Zheng Wu and Qi Jiang and Beihua Dong and Olaniyi Amos Fawole and Di Wu and Su Chen and Xian Li and Kunsong Chen}, doi = {10.1002/advs.202503567}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e03567}, shortjournal = {Adv. Sci.}, title = {Fabrication of dual photodynamic enhanced antimicrobial CDs@ZIF-8/Polycaprolactone/Ethyl cellulose nanofibrous films for fruit preservation}, volume = {12}, year = {2025}, }
• (2025). Continuously alternating storage of anion and cation toward a high-performance bipolar conjugated polymer cathode. ADVS, 12(35), e03485. (www)

  @article{ , abstract = {Rapid and sequential ion insertion is impeded in the single host organic electrodes, primarily due to Coulomb repulsion between ions with identical charges, which creates an irreconcilable conflict between capacity and rate performance. Herein, a bipolar conjugated donor-acceptor (D-A) polymer (PTZ-Pz) is designed and synthesized with the co-storage of opposite ions by utilizing the electron-donating phenothiazine (PTZ) unit and the electron-withdrawing phenazine (Pz) unit as the building blocks. It demonstrates that the continuously alternate storage of anions and cations can facilitate the charge transfer processes and thereby accelerate the reaction dynamic of the PTZ-Pz cathode. Consequently, the D-A polymer PTZ-Pz shows a high specific capacity of 208 mAh g −1 . The electrode exhibits an ultra-long cyclability of more than 80 000 cycles, with an excellent rate performance of 116 mAh g −1 at 20 A g −1 . Benefiting from the fast kinetics, the PTZ-Pz cathode can operate well at a high mass loading of 44.2 mg cm −2 . The enhanced energy and power density via alternate storage anions and cations mode may facilitate the exploration of new electrode materials for aluminum batteries.}, archive = {J_ADVS}, author = {Lian-Wei Luo and Wenyan Ma and Siteng Zhu and Chong Zhang and Jia-Xing Jiang}, doi = {10.1002/advs.202503485}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e03485}, shortjournal = {Adv. Sci.}, title = {Continuously alternating storage of anion and cation toward a high-performance bipolar conjugated polymer cathode}, volume = {12}, year = {2025}, }
• (2025). Characterization of b cell responses in rainbow trout (Oncorhynchus mykiss) affected by red mark syndrome. ADVS, 12(35), e03047. (www)

  @article{ , abstract = {Red mark syndrome (RMS) is a disease affecting rainbow trout. Although the precise etiology of this disease is still under debate, a Midichloria-like organism (MLO) is suspected as the triggering agent. RMS provokes characteristic skin lesions. Previous investigations pointed to a local immune response characterized by a B cell influx. To elaborate on these findings, here, this study extensively characterizes systemic and local B cell responses in RMS-affected fish. The local influx of IgM+ B cells to the skin lesions is confirmed, and a differentiation of these B cells to plasma-like cells is demonstrated. IgM repertoires suggested a polyclonal activation of local B cells and some trafficking between skin and head kidney. Finally, the fact that transcripts of the gene coding for MLO 16S rRNA are found in sorted skin IgM + B cells and non-IgM + skin leukocytes reveals the capacity of this intracellular bacterium to be internalized by B cells, where it may possibly directly interfere with intracellular pathways. The data significantly advances the knowledge on RMS and provides another example of a fish pathology in which fish B cells seem pivotal, possibly because of the specific ways in which teleost B cells intrinsically sense and respond to pathogens.}, archive = {J_ADVS}, author = {J Germán Herranz-Jusdado and Samuel Vicente-Gil and Esther Morel and Pablo Jiménez-Barrios and Rocío Simón and Pedro Perdiguero and Diana Martín and Marta Vargas-Ramírez and Niels Lorenzen and Jacob Günther Schmidt and Carolina Tafalla}, doi = {10.1002/advs.202503047}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e03047}, shortjournal = {Adv. Sci.}, title = {Characterization of b cell responses in rainbow trout (Oncorhynchus mykiss) affected by red mark syndrome}, volume = {12}, year = {2025}, }
• (2025). Adipocytes promote cisplatin resistance through secreting A1BG and regulating NAMPT/PARP1 axis-mediated DNA repair in osteosarcoma. ADVS, 12(35), e02926. (www)

  @article{ , abstract = {Obesity is increasingly recognized as a negative prognostic factor for cancers, including osteosarcoma. However, the mechanisms linking obesity to chemoresistance in osteosarcoma remain unclear. This study found obesity is significantly associated with poor responses to cisplatin-based chemotherapy in osteosarcoma patients. In vitro, adipocyte-conditioned medium (Adi-CM) induced cisplatin resistance, while peritumoral adipocytes and diet-induced obesity (DIO) reduce the cisplatin efficacy in vivo. Mechanistically, Adi-CM enhanced DNA repair by the PARP1/ATM pathway activation. Proteomic analysis identified A1BG, a secreted protein upregulated in adipocytes from chemoresistant patients, as a key mediator of this effect. A1BG depletion in adipocytes restored cisplatin sensitivity, whereas recombinant A1BG enhanced resistance and promoted DNA repair. Further investigation revealed a direct interaction between A1BG and NAMPT, leading to the stabilization of NAMPT and an increased NAD + production. This enhanced PARP1 activity and subsequent DNA repair. Importantly, pharmacological inhibition of NAMPT and PARP1 using FK886 and Olaparib, respectively, reversed Adi-CM-induced cisplatin resistance and restored cisplatin sensitivity in osteosarcoma cells, DIO mouse models, and patient-derived organoids. A novel link between obesity and cisplatin resistance in osteosarcoma is established, highlighting the A1BG/NAMPT/PARP1 axis as a critical driver. Targeting this axis may represent a promising therapeutic strategy for overcoming obesity-associated chemoresistance in osteosarcoma.}, archive = {J_ADVS}, author = {Yonghui Liang and Zhaohui Li and Lina Tang and Zhen Pan and Xiang Fei and Chen Tan and Aina He and Qingcheng Yang and Dongdong Cheng}, doi = {10.1002/advs.202502926}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e02926}, shortjournal = {Adv. Sci.}, title = {Adipocytes promote cisplatin resistance through secreting A1BG and regulating NAMPT/PARP1 axis-mediated DNA repair in osteosarcoma}, volume = {12}, year = {2025}, }
• (2025). CD74 blockade disrupts endothelial migrasome signaling to prevent inflammatory macrophage differentiation and inhibit atherosclerotic progression. ADVS, 12(35), e02838. (www)

  @article{ , abstract = {Endothelial dysfunction and abnormal activation of the monocyte-macrophage system form a critical loop in atherosclerosis. The role of migrasomes in endothelial-immune interactions remains unclear. This study explores migrasome evolution in the atherosclerotic (AS) microenvironment, highlighting their function as amplifiers in the inflammatory cascade. Through analysis of ApoE −/- mouse models and single-cell multi-omics data, migrasome activity is mapped using Gene Set Variation Analysis (GSVA) algorithms. Co-culture systems and anti-Cluster of differentiation 74 (CD74) blocking experiments are employed to investigate immune-metabolic reprogramming triggered by migrasome cargo signaling. Advanced imaging and functional studies demonstrated that the interaction between amyloid protein precursor (APP) ligands on endothelial cells and CD74 receptors on macrophages triggers endothelial cells to produce more migrasomes. The clinical relevance of these findings is confirmed through CD74 blocking experiments, which effectively disrupted migrasome-mediated signaling and attenuated atherosclerotic progression. Importantly, migrasome content is positively correlated with the severity of atherosclerosis. These results fundamentally challenge existing paradigms of intercellular communication by establishing migrasomes as dual-functional entities – serving both as biomarkers of endothelial stress and molecular drivers of immune microenvironment deterioration. The discovery of the “migrasome-APP-CD74” signaling network opens new avenues for developing organelle-targeted therapies to interrupt the vicious cycle of vascular inflammation.}, archive = {J_ADVS}, author = {Kangnan Zhang and Jiong Chen and Zhenhua Zhu and Hong Hu and Qinghui Zhang and Rongrong Jia and Na Wang and Shihao Xiang and Yong Zhou and Yuehong Wang and Ling Xu}, doi = {10.1002/advs.202502838}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e02838}, shortjournal = {Adv. Sci.}, title = {CD74 blockade disrupts endothelial migrasome signaling to prevent inflammatory macrophage differentiation and inhibit atherosclerotic progression}, volume = {12}, year = {2025}, }
• (2025). BInD: Bond and interaction-generating diffusion model for multi-objective structure-based drug design. ADVS, 12(35), e02702. (www)

  @article{ , abstract = {Recent remarkable advancements in geometric deep generative models, coupled with accumulated structural data, enable structure-based drug design (SBDD) using only target protein information. However, existing models often struggle to balance multiple objectives, excelling only in specific tasks. BInD, a diffusion model with knowledge-based guidance, is introduced to address this limitation by co-generating molecules and their interactions with a target protein. This approach ensures balanced consideration of key objectives, including target-specific interactions, molecular properties, and local geometry. Comprehensive evaluations demonstrate that BInD achieves robust performance across all objectives, matching or surpassing state-of-the-art methods. Additionally, an NCI-driven molecule design and optimization method is proposed, enabling the enhancement of target binding and specificity by elaborating the adequate interaction patterns.}, archive = {J_ADVS}, author = {Joongwon Lee and Wonho Zhung and Jisu Seo and Woo Youn Kim}, doi = {10.1002/advs.202502702}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e02702}, shortjournal = {Adv. Sci.}, title = {BInD: Bond and interaction-generating diffusion model for multi-objective structure-based drug design}, volume = {12}, year = {2025}, }
• (2025). TRIM21-mediated k11-linked ubiquitination of ID1 suppresses tumorigenesis and promotes cuproptosis in esophageal squamous cell carcinoma. ADVS, 12(35), e02501. (www)

  @article{ , abstract = {Inhibitor of DNA binding 1 (ID1) is a key transcriptional regulator involved in the development of various cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanisms regulating ID1 ubiquitination in ESCC are not well understood. This study identifies TRIM21 as a novel E3 ubiquitin ligase that targets ID1 for K11-linked ubiquitination at lysine 91. Unlike typical ubiquitination that marks proteins for degradation, TRIM21-mediated K11 ubiquitination does not affect ID1 stability. Instead, it disrupts the ID1-TCF12 interaction, releasing TCF12 to activate SLC31A1, a copper transporter. Elevated SLC31A1 expression increases intracellular copper, inducing cuproptosis and inhibiting ESCC cell proliferation and tumor growth. Functional assays show that overexpressing TRIM21 suppresses ESCC progression, while TRIM21 knockdown promotes growth. Clinically, low TRIM21 expression correlates with advanced disease stage and poorer patient survival rate, underscoring its prognostic value. Additionally, Sorafenib treatment upregulates TRIM21, enhancing ID1 ubiquitination, increasing SLC31A1 expression, and inducing cuproptosis. These findings uncover the TRIM21-ID1-TCF12-SLC31A1 axis as a critical pathway in ESCC progression, suggesting that targeting this axis with Sorafenib can offer a promising therapeutic strategy for inhibiting tumor growth and improving patient outcomes.}, archive = {J_ADVS}, author = {Lei Li and Yuqing Wang and Ruoxi Tian and Tianshuo Yang and Yaxin Liu and Baoen Shan and Lianmei Zhao}, doi = {10.1002/advs.202502501}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e02501}, shortjournal = {Adv. Sci.}, title = {TRIM21-mediated k11-linked ubiquitination of ID1 suppresses tumorigenesis and promotes cuproptosis in esophageal squamous cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Comprehensive characterization of the immune microenvironment based on nested resampling machine learning framework identifies TRAF3 interacting protein 3 as a promising regulator to improve the resistance to immunotherapy in glioma. ADVS, 12(35), e02271. (www)

  @article{ , abstract = {Diffuse glioma, the most prevalent and malignant intracranial tumor, presents a formidable challenge due to its immunosuppressive microenvironment, which complicates conventional therapeutic approaches. This study conducted a comprehensive prognostic meta-analysis involving 2,968 patients with diffuse glioma and established a comprehensive machine learning framework with nested resampling of 18 machine learning algorithms, and developed the Immune Glioma Survival Signature (IGLoS). This signature, comprising CCL19, ICOSLG, IL11, PTGES, TNFAIP3, and TRAF3IP3, has been demonstrated to predict survival outcomes across a range of cancers and to correlate with tumor progression at the level of multi-omics. It is noteworthy that the IGLoS score enables precise patient stratification for personalized cancer treatments and elucidates pivotal resistance mechanisms to immunotherapy. Furthermore, siRNA screening has underscored the critical role of TRAF3IP3 in modulating PDL1 expression and immune pathways, with implications on the ERK pathway and NFATC2 involvement. Through single-cell analysis of published and in-house datasets, TRAF3IP3 exhibited selective enrichment in NPC-like and MES-like tumor cells, and showed a dual functionality in mediating T-Cell Exhaustion. Targeting TRAF3IP3 emerges as a promising avenue to combat immunotherapy resistance, particularly in glioma, thus paving the way for precision medicine.}, archive = {J_ADVS}, author = {Yanbo Yang and Fei Wang and Yulian Zhang and Run Huang and Chuanpeng Zhang and Lu Zhao and Hanhan Dang and Xinyu Tao and Yue Lu and Dengfeng Lu and Yunsheng Zhang and Kun He and Jiancong Weng and Zhouqing Chen and Zhong Wang and Yanbing Yu}, doi = {10.1002/advs.202502271}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e02271}, shortjournal = {Adv. Sci.}, title = {Comprehensive characterization of the immune microenvironment based on nested resampling machine learning framework identifies TRAF3 interacting protein 3 as a promising regulator to improve the resistance to immunotherapy in glioma}, volume = {12}, year = {2025}, }
• (2025). ORL@Cu-MOF boost cuproptosis and suppress fatty acid metabolism for cancer lymph node metastasis synergistic therapy. ADVS, 12(35), e02154. (www)

  @article{ , abstract = {Lymph node metastasis (LNM) is one of the significant characteristics of poor prognosis in oral squamous cell carcinoma (OSCC), strongly associated with high mortality rates. Immunotherapy has emerged as a crucial treatment modality for OSCC LNM, yet its limited response rate severely restricts its clinical application. Cuproptosis, a newly discovered immunogenic cell death (ICD), is often hindered by lipid metabolic reprogramming in tumor cells, which also contributes significantly to the lack of response to immunotherapy. Herein, a metal-organic framework (MOF) nanodrug loaded with orlistat (ORL) is developed, designated as ORL@Cu-MOF. This nanodrug is designed to respond and release under the high glutathione (GSH) stimulus of the tumor microenvironment (TME), thereby inducing cuproptosis and suppressing fatty acid metabolism in OSCC cells. In vivo, ORL@Cu-MOF effectively triggers cuproptosis and inhibits fatty acid metabolism, exerting antitumor effects in mouse models and remodeling the TME. Furthermore, the combination of ORL@Cu-MOF with programmed death receptor-1 (αPD-1) significantly enhances immunotherapy outcomes, transforming “cold tumors” into “hot tumors”. This study is the first to report the synergistic use of cuproptosis induction and fatty acid metabolism suppression in the treatment of metastatic cancer, offering novel insights for the care and management of LNM of OSCC.}, archive = {J_ADVS}, author = {Zi-Zhan Li and Yi Liu and Kan Zhou and Lei-Ming Cao and Guang-Rui Wang and Jinmei Wu and Yi-Fu Yu and Yao Xiao and Bing Liu and Qiuji Wu and Zhiyong Song and Lin-Lin Bu}, doi = {10.1002/advs.202502154}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e02154}, shortjournal = {Adv. Sci.}, title = {ORL@Cu-MOF boost cuproptosis and suppress fatty acid metabolism for cancer lymph node metastasis synergistic therapy}, volume = {12}, year = {2025}, }
• (2025). Discovery of novel ferrites for thermochemical h2 production cycle via high-throughput thermodynamic screening. ADVS, 12(35), e01846. (www)

  @article{ , abstract = {This study highlights the discovery of the (MgMnCo) 1-x Fe x O y system, identified through a high-throughput thermodynamic screening utilizing the CALPHAD methodology, as a highly efficient material system for two-step thermochemical water splitting under mitigated redox reaction conditions. The screening focuses on a wide range of ferrite systems (M 1-x Fe x O y , M═Mn, Al, Mg, Co, Ni, 0.05< x< 0.95) and particularly underscores the (MgMnCo) 1-x Fe x O y system for its high oxygen capacity during redox cycles. Remarkably, (MgMnCo) 0.65 Fe 0.35 O y achieves state-of-the-art turnover number and a higher theoretical solar-to-fuel efficiency of 43.6% compared to benchmark ceria at 17.4%. CALPHAD-based thermodynamic analysis and spectroscopic electronic structure analysis reveal that the excellent redox performance of this material is attributed to the simultaneous contributions of Fe and Mn cations. This dual active feature is discovered for the first time in any ferrite cycles to the best of available knowledge, offering significant opportunities to explore new multi-cation ferrite systems in the related research field. In addition, the screening methodology employed here can potentially be extended to other thermochemical processes.}, archive = {J_ADVS}, author = {Dongkyu Lee and Joonhyun Nam and Byeong-Gyu Park and Hyemin Kim and In-Ho Jung and Hyungyu Jin}, doi = {10.1002/advs.202501846}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e01846}, shortjournal = {Adv. Sci.}, title = {Discovery of novel ferrites for thermochemical h2 production cycle via high-throughput thermodynamic screening}, volume = {12}, year = {2025}, }
• (2025). Real-time probing of morphological evolution and recrystallization during solvent annealing in blade-coated all-polymer organic solar cells using in situ X-ray scattering. ADVS, 12(35), e01823. (www)

  @article{ , abstract = {Optimizing the morphology of the active layer is crucial for achieving high photovoltaic conversion efficiency in all-polymer solar cells (APSCs). Solvent vapor annealing (SVA) is an essential post-treatment strategy for controlling active layer morphology. However, most current SVA are conducted ex situ, limiting their ability to accurately reveal the morphological evolution of active layers of APSCs. In this study, in situ synchrotron radiation GIWAXS and in situ UV–vis spectroscopy combined with GISAXS is used to monitor the morphological evolution of PM6/PY-IT blends during the SVA process in real-time. Results showed that the PY-IT absorption peak exhibited a red shift under a nonpolar carbon disulfide vapor, while a blue shift is observed during the SVA process with a polar chloroform vapor. The SVA process can be divided into three stages: solvent swelling, recrystallization, and molecular rearrangement. For thermally pre-annealed samples subjected to chloroform SVA, the power conversion efficiency (PCE) increased by 15.1%. The improved PCE stems from reduced crystal plane spacing (d-spacing), enhanced crystal coherence length, and optimal phase separation via SVA. Pre-annealing suppresses excessive swelling, emphasizing the reordering dynamical role in the morphology of APSCs. This study offers insights into balancing SVA conditions to maximize performance and minimize adverse effects.}, archive = {J_ADVS}, author = {Jialiang Hao and Yang Feng and Qianyi Ma and Hongxiang Li and Chunxia Hong and Chen Hou and Ying Wang and Yang Jing and Yiwen Li and Guangfeng Liu and Xiuhong Li and Aiguo Li and Fenggang Bian and Ruijie Ma and Yuanyang Wang and Yuying Huang and Chunming Yang}, doi = {10.1002/advs.202501823}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e01823}, shortjournal = {Adv. Sci.}, title = {Real-time probing of morphological evolution and recrystallization during solvent annealing in blade-coated all-polymer organic solar cells using in situ X-ray scattering}, volume = {12}, year = {2025}, }
• (2025). Bacteroides fragilis-derived outer membrane vesicles deliver MiR-5119 and alleviate colitis by targeting PD-l1 to inhibit GSDMD-mediated neutrophil extracellular trap formation. ADVS, 12(35), e00781. (www)

  @article{ , abstract = {Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system. Non-toxigenic Bacteroides fragilis , a common human colon symbiote, has been shown to alleviate colitis. However, the underlying mechanisms of this alleviation remain incompletely understood. Herein, it is demonstrated that promoting the secretion of B. fragilis outer membrane vesicles (Bf OMVs+ ) enhances its ability to alleviate dextran sodium sulfate (DSS)-induced colitis, while inhibiting B. fragilis OMV secretion (Bf OMVs− ) reduces this effect. Bf OMVs+ alleviates colitis by inhibiting neutrophil recruitment and neutrophil extracellular trap (NET) formation. Further, B. fragilis OMVs (Bf-OMVs) are isolated and extracted, then administered them intraperitoneally to DSS-induced colitis mice, observing that Bf-OMVs can target intestinal tissues, the spleen, and bone marrow, and they are internalized by neutrophils to inhibit NET formation, thereby alleviating colitis. The expression profile of miRNAs in Bf-OMVs is assessed, revealing that Bf-OMVs are enriched with mmu-miR-like sRNA, miR-5119, which targets and inhibits PD-L1, leading to the suppression of GSDMD-mediated NET release and promoting the proliferation of intestinal stem cells (ISCs), culminating in the alleviation of colitis. These findings provide new insights into the role of B. fragilis OMVs in the pathogenesis and treatment of IBD.}, archive = {J_ADVS}, author = {Yi Yang and Lanmengxi Yang and Yilin Yang and Haiyi Deng and Shiyu Su and Yinxiao Xia and Jin Su and Yuheng Liu and Junwei Wu and Jing Zhang and Yao Liao and Lifu Wang}, doi = {10.1002/advs.202500781}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e00781}, shortjournal = {Adv. Sci.}, title = {Bacteroides fragilis-derived outer membrane vesicles deliver MiR-5119 and alleviate colitis by targeting PD-l1 to inhibit GSDMD-mediated neutrophil extracellular trap formation}, volume = {12}, year = {2025}, }
• (2025). PTf-SRiApt targeting SCAF4-POLR2A interaction suppresses tumor growth and promotes antitumor immunity in triple-negative breast cancer. ADVS, 12(35), e00433. (www)

  @article{ , abstract = {The interaction between SCAF4 and RNA polymerase II (POLR2A) is crucial for proper mRNA termination, with its dysregulation leading to truncated mRNAs and nonfunctional proteins, impairing cellular growth. Despite its potential relevance, the role of this interaction in triple-negative breast cancer (TNBC) remains unexplored due to the lack of effective molecular tools. To address this, we employed SRiApt, an aptamer generated through the recently established Blocker-SELEX pipeline. Its biological stability is improved by phosphorothioate modifications to form PT f -SRiApt. Using this aptamer, the critical role of the SCAF4-POLR2A interaction in driving TNBC tumor growth and immune regulation is uncovered. PT f -SRiApt effectively inhibits tumor growth and induces cell cycle arrest in TNBC cells with elevated SCAF4 and POLR2A expression. Additionally, PT f -SRiApt promotes premature mRNA termination, boosting antigen presentation and promoting T-cell infiltration. Analysis of patient samples further confirmed the negative correlation between SCAF4-POLR2A interaction and the effectiveness of immunotherapy, highlighting the potential of PT f -SRiApt in improving immune efficacy. Together, the work provides a powerful tool not only for dissecting previously “undruggable” protein-protein interactions but also for enhancing tumor immunogenicity and reshaping the tumor microenvironment.}, archive = {J_ADVS}, author = {Liyan Fei and Yichun Pan and Jie Zhai and Tongqing Li and Yuxin Zhou and Sheyu Zhang and Juan Wei and Qian Hu and Xueying Liu and Lu Guo and Weizhu Wu and Yong Wei and Qin Wu and Weihong Tan}, doi = {10.1002/advs.202500433}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e00433}, shortjournal = {Adv. Sci.}, title = {PTf-SRiApt targeting SCAF4-POLR2A interaction suppresses tumor growth and promotes antitumor immunity in triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). Bionic microneedle patch inspired by drosophila tarsal paws boosts healing in bacterial infectious stomatitis. ADVS, 12(35), e00432. (www)

  @article{ , abstract = {Bacterial infectious stomatitis (BIS), characterized by severe infections overlaying ulcers, poses complex therapeutic challenges and often results in prolonged healing, leading to significant patient discomfort. To address this clinical challenge, a biomimetic microneedle (MN) suction cup is designed inspired by the tarsal claw of Drosophila. The suction cup component is crafted from polyvinyl alcohol (PVA) hydrogel, while the MN section, embedded within the suction cup, comprises a thermoresponsive and antibacterial composite hydrogel infused with the drug S-nitrosoglutathione (GSNO). This innovative design not only ensures strong adhesion to moist surfaces but also provides substantial antibacterial and anti-inflammatory effects, controlled drug release, active promotion of concentric wound contraction, and enhanced vasodilation, thereby facilitating rapid and comprehensive healing of BIS. The multifunctionality of the MN suction cup patch developed in this study represents a significant innovation over traditional treatment methods and holds potential for widespread application in dental clinics.}, archive = {J_ADVS}, author = {Jiaqi Qin and Cewen Hu and Xiaohong Ran and Huajing Zeng and Jie Zhang and Bin Liu and Zengjie Fan}, doi = {10.1002/advs.202500432}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e00432}, shortjournal = {Adv. Sci.}, title = {Bionic microneedle patch inspired by drosophila tarsal paws boosts healing in bacterial infectious stomatitis}, volume = {12}, year = {2025}, }
• (2025). Calcitonin gene-related peptide (CGRP)-expressing neurons in the external lateral parabrachial area regulate pain-induced sleep disturbances. ADVS, 12(35), e00325. (www)

  @article{ , abstract = {Given that sleep and pain are bidirectionally related, we investigated the neural circuits underlying pain-induced sleep disturbances using two acute pain models. Activation of nociceptors in acute inflammatory pain (AIP) significantly reduced sleep by 45–50% in the first 6 h, with reduced sleep spindle density for 1–3 h post-AIP. Additionally, an “optogenetic pain (Opto-Pain)” model is implemented to produce acute peripheral pain-induced awakenings that reduced sleep comparable to AIP. Both pain models are used to test the role of wake-promoting neurons in the parabrachial nucleus that express Calcitonin Gene-Related Peptide (PBel CGRP ) in relaying nociceptive stimulus from the dorsal horn as part of the spine-ponto-amygdaloid tract. Blocking PBel CGRP neurons with genetic ablation or optogenetic inhibition attenuated sleep loss. To dissect the PBel CGRP pathways, the terminals are then optogenetically silenced post-AIP and found the reversal of sleep disturbances in the following descending order of effectiveness: substantia innominata of the basal forebrain (SI-BF) > central nucleus of the amygdala (CeA) > bed nucleus of the stria terminalis (BNST) > the lateral hypothalamus (LH). In SI-BF and CeA, a similar reversal of AIP-induced sleep loss occurred with pharmacological blocking of either CGRP or NMDA receptors. The results are relevant to emerging pain therapies aiming to attenuate sleep disturbances.}, archive = {J_ADVS}, author = {Nicole Lynch and Roberto De Luca and Richard L Spinieli and Enrico Rillosi and Renner C Thomas and Samuel Sailesh and Nishta Gangeddula and Janayna D Lima and Sathyajit S Bandaru and Elda Arrigoni and Agustin Melo-Carrillo and Rami Burstein and Stephen Thankachan and Satvinder Kaur}, doi = {10.1002/advs.202500325}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e00325}, shortjournal = {Adv. Sci.}, title = {Calcitonin gene-related peptide (CGRP)-expressing neurons in the external lateral parabrachial area regulate pain-induced sleep disturbances}, volume = {12}, year = {2025}, }
• (2025). Role of tunneling nanotubes in arachidonic acid transfer and macrophage function reprogramming in intrahepatic cholangiocarcinoma. ADVS, 12(35), e00148. (www)

  @article{ , abstract = {Tumor-associated macrophages (TAMs) play a crucial role in tumor progression within the tumor microenvironment (TME) through phenotypic plasticity and functional modulation. While tunneling nanotubes (TNTs) mediate intercellular communication, their role in shaping TAMs phenotypes and function remains unclear. This study explores how TNTs facilitate the transfer of tumor-derived materials, particularly fatty acids, to TAMs, affecting macrophage polarization and function. Single-cell RNA sequencing identified heterogeneous macrophage subpopulations in the TME. Enrichment analysis pinpointed key substances transferred via TNTs. Lipidomics and metabolomics analyzed the fatty acids involved. In vitro and in vivo experiments validated TNTs-mediated material transfer, and transcriptomic analysis revealed the associated signaling pathways. TNTs are the primary route for transferring tumor-derived fatty acids, notably arachidonic acid (AA), to macrophages. This transfer reprogrammed TAMs from anti-tumor CD5L + to pro-tumor TREM2 + phenotypes, increasing CCL18 secretion, reducing phagocytic activity, and impairing CD8 + T cell proliferation. Mechanistically, AA activated the PI3K-AKT pathway, driving TAMs polarization. These findings are confirmed in xenograft models, where TNTs-induced TAMs exhibited enhanced pro-tumor properties. TNTs-mediated transfer of tumor-derived AA reprograms TAMs via PI3K-AKT activation, promoting immune suppression and tumor progression, highlighting TNTs and PI3K-AKT as potential therapeutic targets in iCCA.}, archive = {J_ADVS}, author = {Meiru Chen and Shangyumeng Zhao and Xiaoli Xie and Jiaqi Wang and Miao Su and Lixian Zhang and Ruolin Cui and Dongqiang Zhao}, doi = {10.1002/advs.202500148}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e00148}, shortjournal = {Adv. Sci.}, title = {Role of tunneling nanotubes in arachidonic acid transfer and macrophage function reprogramming in intrahepatic cholangiocarcinoma}, volume = {12}, year = {2025}, }
• (2025). Irisin attenuates pulmonary vascular remodeling in pulmonary arterial hypertension via ubiquitin-mediated regulation of ENO1. ADVS, 12(35), e00096. (www)

  @article{ , abstract = {Pulmonary vascular remodeling, which current therapeutic targets fail to alleviate disease severity, plays a key role in pulmonary arterial hypertension (PAH). Irisin is identified as a protective factor involved in regulating inflammation and oxidative stress, but its role in PAH remains unknown. To investigate, plasma irisin levels and its local pulmonary artery expression are measured in patients with PAH and mouse models. Irisin expression is significantly decreased in patients with PAH and PAH mouse models. Furthermore, overexpression and exogenous injection of irisin effectively alleviate hemodynamic and right-heart function in PAH mouse models, meanwhile, it also reverses proliferation and cell cycle progression of pulmonary artery smooth muscle cells (PASMCs). To illustrate the mechanism of irisin exerts on PAH, Enolase 1 is identified as a key irisin-interacting protein. Irisin suppresses proliferation of PDGF-induced PASMCs by promoting ubiquitination status of Enolase 1 via E3 ligase of down regulated protein 4 in neural precursor cell development. Co-immunoprecipitation and molecular docking analyses verifies the interaction and binding sites between irisin and its interactive proteins. Overall, these findings suggest that, irisin is a novel protective factor downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell proliferation and pulmonary vascular remodeling in PAH.}, archive = {J_ADVS}, author = {Na Sun and Yong-Bing Wang and Jing Huang and Run-Wei Deng and Hui-Yu He and Lei Gao and Xuan Gao and You-Li Fan and Yan Cong and Yao-Lei Guo and Yi-Qiang Chen and Gui-Jia Wang and Shao-Hong Fang and Xia Gu and Bo Yu and Bing-Xiang Wu}, doi = {10.1002/advs.202500096}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {e00096}, shortjournal = {Adv. Sci.}, title = {Irisin attenuates pulmonary vascular remodeling in pulmonary arterial hypertension via ubiquitin-mediated regulation of ENO1}, volume = {12}, year = {2025}, }
• (2025). Quantum kernel learning for small dataset modeling in semiconductor fabrication: Application to ohmic contact (Adv. sci. 35/2025). ADVS, 12(35), 71646. (www)

  @article{ , archive = {J_ADVS}, author = {Zeheng Wang and Fangzhou Wang and Liang Li and Zirui Wang and Timothy van der Laan and Ross C. C. Leon and Jing-Kai Huang and Muhammad Usman}, doi = {10.1002/advs.71646}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {71646}, shortjournal = {Adv. Sci.}, title = {Quantum kernel learning for small dataset modeling in semiconductor fabrication: Application to ohmic contact (Adv. sci. 35/2025)}, volume = {12}, year = {2025}, }
• (2025). Maximizing efficacy of cancer nanovaccines and immune cells landscape in responders and non-responders to immunotherapy (Adv. sci. 35/2025). ADVS, 12(35), 71643. (www)

  @article{ , archive = {J_ADVS}, author = {Xiangxiang Xu and Lu Diao and Jin Wang and Ao Zhu and Xianlan Chen and Yan Zheng and Yuhan Liu and Kang Hu and Jiashan Zhu and Cheng Ding and Chang Li and Yunzhi Pan and Jun Zhao and Mi Liu}, doi = {10.1002/advs.71643}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {71643}, shortjournal = {Adv. Sci.}, title = {Maximizing efficacy of cancer nanovaccines and immune cells landscape in responders and non-responders to immunotherapy (Adv. sci. 35/2025)}, volume = {12}, year = {2025}, }
• (2025). FemXpress: Systematic analysis of x chromosome inactivation heterogeneity in female single-cell RNA-seq samples (Adv. sci. 35/2025). ADVS, 12(35), 71642. (www)

  @article{ , archive = {J_ADVS}, author = {Xin Wang and Yingke Ma and Fan Li and Wentao Cui and Tianshi Pan and Siqi Wang and Sinan Ma and Qingtong Shan and Chao Liu and Yukai Wang and Ying Zhang and Yuanchun Zhou and Wei Li and Pengfei Wang and Qi Zhou and Guihai Feng}, doi = {10.1002/advs.71642}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {71642}, shortjournal = {Adv. Sci.}, title = {FemXpress: Systematic analysis of x chromosome inactivation heterogeneity in female single-cell RNA-seq samples (Adv. sci. 35/2025)}, volume = {12}, year = {2025}, }
• (2025). Enhanced media optimize bovine myogenesis in 2D and 3D models for cultivated meat applications (Adv. sci. 35/2025). ADVS, 12(35), 71641. (www)

  @article{ , archive = {J_ADVS}, author = {Christine L. Trautmann and Adhideb Ghosh and Ali Kerem Kalkan and Falko Noé and Ori Bar-Nur}, doi = {10.1002/advs.71641}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {71641}, shortjournal = {Adv. Sci.}, title = {Enhanced media optimize bovine myogenesis in 2D and 3D models for cultivated meat applications (Adv. sci. 35/2025)}, volume = {12}, year = {2025}, }
• (2025). Quantum valley hall effect-based coupler with continuously tunable transmission for topological information communication (Adv. sci. 35/2025). ADVS, 12(35), 71640. (www)

  @article{ , archive = {J_ADVS}, author = {Keita Funayama and Kenichi Yatsugi and Hiroya Tanaka and Hideo Iizuka}, doi = {10.1002/advs.71640}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {71640}, shortjournal = {Adv. Sci.}, title = {Quantum valley hall effect-based coupler with continuously tunable transmission for topological information communication (Adv. sci. 35/2025)}, volume = {12}, year = {2025}, }
• (2025). Monitoring the dynamics of alzheimer's disease biomarkers and the APOE–Tau axis via human cerebral organoids with immuno-SERS (Adv. sci. 35/2025). ADVS, 12(35), 71639. (www)

  @article{ , archive = {J_ADVS}, author = {Yongjae Jo and Youngjun Kim and Rian Kang and Seho Lee and Dang Du Nguyen and Soomin Park and Dongjoon Lee and Jong Won Han and Inhee Mook-Jung and Luke P. Lee and Jong-Chan Park and Inki Kim}, doi = {10.1002/advs.71639}, journal = {Advanced Science}, month = {9}, number = {35}, pages = {71639}, shortjournal = {Adv. Sci.}, title = {Monitoring the dynamics of alzheimer's disease biomarkers and the APOE–Tau axis via human cerebral organoids with immuno-SERS (Adv. sci. 35/2025)}, volume = {12}, year = {2025}, }
• (2025). A two-protein chemoreceptor complex regulates oxygen thresholds in bacterial magneto-aerotaxis. ADVS, 12(34), e17315. (www)

  @article{ , abstract = {Bacteria in changing environments rely on motility and sensory mechanisms to locate optimal conditions. This process depends on specialized chemoreceptors to sense environmental stimuli. Exceptionally high numbers of chemoreceptor genes are present in magnetotactic bacteria (MTB), which combine magnetic alignment via intracellular magnetic nanoparticles (magnetosomes) and oxygen sensing for a unique navigation strategy toward low-oxygen zones, called magneto-aerotaxis. However, chemoreceptors for aerotaxis in MTB have not been experimentally identified. This study examines chemoreceptors in the model MTB Magnetospirillum gryphiswaldense . Gene deletion analysis shows that M. gryphiswaldens e relies on a complex and partly redundant set of chemoreceptors to sense oxygen. Within this diverse repertoire of chemoreceptors, a receptor formed by two interacting proteins is identified that plays a key role in aerotaxis. Interaction assays and microscopy confirm that both proteins interact within polar-lateral regions in the cell. Moreover, genetic, biochemical, and motility experiments demonstrate that the chemoreceptor complex promotes a cellular response away from oxygen via the redox cofactor flavin adenine dinucleotide (FAD), independent of magnetic fields. These findings provide first insights into how MTB control oxygen sensing at the molecular level, shedding light on the mechanisms underlying bacterial navigation and highly complex chemosensory systems.}, archive = {J_ADVS}, author = {Julian Herz and Carina Weigel and Leonie Scheder and Raz Zarivach and Itay Algov and Yonatan Chemla and Felix Popp and Cornelius Riese and Mohammad A. Charsooghi and Lital Alfonta and Michael M. Meijler and Dirk Schüler and Damien Faivre and Daniel Pfeiffer}, doi = {10.1002/advs.202417315}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e17315}, shortjournal = {Adv. Sci.}, title = {A two-protein chemoreceptor complex regulates oxygen thresholds in bacterial magneto-aerotaxis}, volume = {12}, year = {2025}, }
• (2025). Rictor ameliorates acute antibody-mediated rejection following kidney transplantation by suppressing macrophage m1 polarization through p65-NLRP3 axis. ADVS, 12(34), e17119. (www)

  @article{ , abstract = {Antibody-mediated rejection (ABMR) represents the leading cause of kidney allograft failure over a long term after transplantation. Early infiltration of macrophages predicts the adverse outcome of grafts, yet the underlying mechanisms remain to be elucidated. Significant infiltration of M1 macrophages and upregulation of Rictor in macrophages are observed in ABMR allografts. Deficiency of Rictor in macrophages exacerbates histological injury and shortens the survival of ABMR allografts by promoting macrophage M1 polarization. Additionally, loss of Rictor in primary bone marrow-derived macrophages facilitates NLRP3 inflammasome activation through activating NF-κB. Mechanistically, Rictor upregulates E3 ubiquitin ligase SOCS1 to enhance K48-linked ubiquitination of p65, thereby suppressing macrophage M1 polarization. Taken together, Rictor ameliorates acute ABMR following kidney transplantation by suppressing macrophage M1 polarization through the p65-NLRP3 axis and may serve as a therapeutic target for ABMR.}, archive = {J_ADVS}, author = {Bin Ni and Chengcheng Yang and Junqi Zhang and Zhou Hang and Ming Zheng and Dengyuan Feng and Qinghuan Shen and Jinxu Miao and Xulin Sun and Li Sun and Baixin Shen and Min Gu and Zijie Wang}, doi = {10.1002/advs.202417119}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e17119}, shortjournal = {Adv. Sci.}, title = {Rictor ameliorates acute antibody-mediated rejection following kidney transplantation by suppressing macrophage m1 polarization through p65-NLRP3 axis}, volume = {12}, year = {2025}, }
• (2025). Scaffolding protein ENH promotes tumor angiogenesis and growth through macrophage recruitment and polarization. ADVS, 12(34), e16476. (www)

  @article{ , abstract = {Angiogenesis is vital for tumor growth and metastasis, with tumor-associated macrophages (TAMs) being key pro-angiogenic cells recruited by tumor-secreted chemokines. High levels of TAMs contribute to tumor progression and antiangiogenic therapy resistance. Therefore, intensive study of the regulatory mechanisms of TAMs recruitment during tumor development is important for the discovery of new antitumor and antiangiogenic therapeutic strategies. Here, we found that in lung adenocarcinoma (LUAD), ENH levels positively correlated with microvessel density and TAMs infiltration. Further exploration revealed that ENH promoted LUAD angiogenesis and growth by stimulating TAMs recruitment and M2 polarization. Mechanistically, ENH in LUAD induced YAP nuclear aggregation to promote CCL5 transcription, thereby increasing monocyte chemotaxis and ultimately increasing TAMs infiltration and M2 polarization. Besides, we found that ENH interacted with YAP through LIM domains, which significantly triggered the formation of YAP-KPNA2 complexes. Consequently, YAP is imported into the nucleus by KPNA2 and then promoted CCL5 transcription. Notably, ENH knockdown also significantly increased the chemosensitivity. Together, ENH functions in LUAD cells to mediate macrophage infiltration and M2 polarization, which in turn promotes tumor angiogenesis and growth, and targeting ENH offers a promising target for antiangiogenic therapy through immune modulation.}, archive = {J_ADVS}, author = {Yueli Shi and Zhiyong Xu and Huan Wang and Bufu Tang and Nueraili Maihemuti and Xinyuan Jiang and Xiuying Chen and Mingshu Xiao and Sujing Jiang and Yun Xu and Peng Xiao and Jiangnan Zhao and Kaiyue Zhang and Mengshu Li and Kai Wang}, doi = {10.1002/advs.202416476}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e16476}, shortjournal = {Adv. Sci.}, title = {Scaffolding protein ENH promotes tumor angiogenesis and growth through macrophage recruitment and polarization}, volume = {12}, year = {2025}, }
• (2025). Prediction of microstructural representativity from a single image. ADVS, 12(34), e14149. (www)

  @article{ , abstract = {In this study, a method is presented for predicting the representativity of the phase fraction observed in a single image (2D or 3D) of a material. Traditional approaches often require large datasets and extensive statistical analysis to estimate the Integral Range, a key factor in determining the variance of microstructural properties. The method leverages the Two-Point Correlation function to directly estimate the variance from a single image, thereby enabling phase fraction prediction with associated confidence levels. The approach is validated using open-source datasets, demonstrating its efficacy across diverse microstructures. This technique significantly reduces the data requirements for representativity analysis, providing a practical tool for material scientists and engineers working with limited microstructural data. To make the method easily accessible, a web-application has been created, https://www.imagerep.io , for quick, simple and informative use of the method.}, archive = {J_ADVS}, author = {Amir Dahari and Ronan Docherty and Steve Kench and Samuel J. Cooper}, doi = {10.1002/advs.202414149}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e14149}, shortjournal = {Adv. Sci.}, title = {Prediction of microstructural representativity from a single image}, volume = {12}, year = {2025}, }
• (2025). Correction to “Targeting the KAT8/YEATS4 axis represses tumor growth and increases cisplatin sensitivity in bladder cancer”. ADVS, 12(34), e13864. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202513864}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e13864}, shortjournal = {Adv. Sci.}, title = {Correction to “Targeting the KAT8/YEATS4 axis represses tumor growth and increases cisplatin sensitivity in bladder cancer”}, volume = {12}, year = {2025}, }
• (2025). The LDH-H3K18La-nur77 axis potentiates immune escape in small cell lung cancer. ADVS, 12(34), e13608. (www)

  @article{ , abstract = {Small cell lung cancer (SCLC) remains a therapeutic challenge due to its aggressive nature and limited response to immunotherapy. This study identifies lactate-induced histone lactylation as a novel epigenetic mechanism in SCLC, contributing to immune escape and poor therapeutic outcomes. By identifying the LDH-H3K18La-Nur77 axis, new insights into the metabolic regulation of immune responses in SCLC are offered. Multi-omics analysis, including metabolomics and TCR sequencing, is used to compare serum samples and immune cell profiles from SCLC patients. Data from Shanzhong cohort (n = 222), along with a validation cohort from the IMpower133 study (n = 264), demonstrates that LDH levels are associated with poorer outcomes following immunotherapy. ChIP-qPCR and luciferase reporter assays reveal that lactate-induced histone lactylation at H3K18La induces transcriptional activation of Nur77 in naïve CD8 + T cells, leading to tonic TCR signaling, which impairs antigen recognition and prevents effective anti-tumor activity. In preclinical SCLC models, lactate inhibition reduces Nur77 expression, restores T cell function, and enhances the efficacy of PD-1 blockade, leading to a decreased tumor burden and improved survival. This study uncovers a novel mechanism of immune escape in SCLC through lactate-driven histone lactylation and provides the first evidence that targeting lactate metabolism can enhance immunotherapy effectiveness.}, archive = {J_ADVS}, author = {Xiaoling Shang and Bo Cheng and Chenyue Zhang and Chenglong Zhao and Ruiqing Wang and Xun Zhang and Dizhi Jiang and Xinyu Zhang and Xinyue Ma and Hongyuan Mao and Zerun Li and Chenhan Huang and Tianzi Wang and Kaiyue Guo and Liwen Wang and Ning Tang and Haiyong Wang}, doi = {10.1002/advs.202413608}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e13608}, shortjournal = {Adv. Sci.}, title = {The LDH-H3K18La-nur77 axis potentiates immune escape in small cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). Cathepsin k aggravates pulmonary fibrosis through promoting fibroblast glutamine metabolism and collagen synthesis. ADVS, 12(34), e13017. (www)

  @article{ , abstract = {Fibroblast collagen synthesis is a hallmark of the pathogenesis and progression of pulmonary fibrosis (PF). However, the factors that trigger the abnormal activation of fibroblasts in PF are still not well understood. Using proteomics and single-cell sequencing dataset screening, extra accumulation of Cathepsin K (CTSK) is detected in the periphery as well as in fibroblasts in the lungs of PF mouse models. Addition of recombinant CTSK (rCTSK) aggravates collagen accumulation and PF progression in bleomycin-induced PF mice. Mechanically, CTSK underwent endocytosis through interaction with sorting nexin 9 (SNX9), which is engaged in TGF-β1 induced SMAD3 activation for downstream glutaminase 1 (GLS1) upregulation and glutamine enrichment. In turn, extra glutamine increases collagen synthesis in fibroblasts. More significantly, serum CTSK levels positively correlated with glutamine levels and poor prognosis in patients with PF. Thus, the results identify CTSK as a novel regulator of fibroblast activation that remodels glutamine metabolism and promotes collagen synthesis during PF pathogenesis. The correlation between peripheral CTSK and glutamine levels implies its future feasibility in the prediction and prevention of PF progression.}, archive = {J_ADVS}, author = {Mengting Chen and Xiaoxiao Meng and Yong Zhu and Dapeng Wang and Mengmeng Wang and Ziyuan Wang and Xue Tian and Jiaxiang Zhang and Zhiying Yue and Zhengfeng Yang and Ruilan Wang}, doi = {10.1002/advs.202413017}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e13017}, shortjournal = {Adv. Sci.}, title = {Cathepsin k aggravates pulmonary fibrosis through promoting fibroblast glutamine metabolism and collagen synthesis}, volume = {12}, year = {2025}, }
• (2025). Genetic deconvolution of embryonic and maternal cell-free DNA in spent culture medium of human preimplantation embryo through deep learning. ADVS, 12(34), e12660. (www)

  @article{ , abstract = {Noninvasive preimplantation genetic testing for aneuploidy based on embryonic cell-free DNA (cfDNA) released in spent embryo culture media (SECM) has brought hope in selecting embryos that are most likely to implant and grow into healthy babies during assisted reproduction. However, maternal DNA contamination in SECM significantly hampers the reliability of embryonic chromosome ploidy profiles, leading to false negative results, particularly at high contamination levels. Here, we present DECENT ( de ep c opy number variation (CNV) r e co n s t ruction), a deep learning method to reconstruct embryonic CNVs and mitigate maternal contamination in SECM from single-cell methylation sequencing of cfDNA. DECENT integrates sequence features and methylation patterns by combining convolution modules, long-short memory, and attention mechanisms to infer the origin of cfDNA reads. The benchmarking study demonstrated DECENT's ability to estimate contamination proportions and restore embryonic chromosome aneuploidies in samples with varying contamination levels. In contaminated SECM clinical samples, including one with more than 80% maternal reads, DECENT achieved consistent CNV recovery with invasive tests. Overall, DECENT contributes to enhancing the diagnostic accuracy and effectiveness of cfDNA-based noninvasive preimplantation genetic testing, establishing a robust groundwork for its extensive clinical utilization in the field of reproductive medicine.}, archive = {J_ADVS}, author = {Zhenyi Zhang and Jie Qiao and Yidong Chen and Peijie Zhou}, doi = {10.1002/advs.202412660}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e12660}, shortjournal = {Adv. Sci.}, title = {Genetic deconvolution of embryonic and maternal cell-free DNA in spent culture medium of human preimplantation embryo through deep learning}, volume = {12}, year = {2025}, }
• (2025). Correction to “Spin magnetic effect activate dual site intramolecular O-O bridging for nickel-iron hydroxide enhanced oxygen evolution catalysis”. ADVS, 12(34), e12423. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202512423}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e12423}, shortjournal = {Adv. Sci.}, title = {Correction to “Spin magnetic effect activate dual site intramolecular O-O bridging for nickel-iron hydroxide enhanced oxygen evolution catalysis”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Label-free and regenerative electrochemical microfluidic biosensors for continual monitoring of cell secretomes”. ADVS, 12(34), e11422. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202511422}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e11422}, shortjournal = {Adv. Sci.}, title = {Correction to “Label-free and regenerative electrochemical microfluidic biosensors for continual monitoring of cell secretomes”}, volume = {12}, year = {2025}, }
• (2025). Water-immersed GaP huygens’ meta-optics for visible structured light generation. ADVS, 12(34), e10467. (www)

  @article{ , abstract = {Underwater photonics is essential for imaging and analysis in biomedical technologies, as well as for communication and autonomous vehicle networks in the Internet of Underwater Things (IoUT). Structured light enables spatial control of beams, offering new opportunities for underwater sensing, imaging, and signal transmission. However, compact and robust water-immersed photonic devices remain challenging to realize. Among various approaches, dielectric metasurfaces are particularly promising for underwater optics due to their flat form factor and subwavelength phase control. Nevertheless, current platforms suffer from instability in liquids, incomplete phase modulation, or strong sensitivity to fabrication imperfections. Here, ultrathin water-immersed metasurfaces composed of gallium phosphide (GaP) Huygens’ integrated resonance units (HIRUs) operating in the visible regime are demonstrated. By leveraging the high refractive index and low optical loss of GaP, and integrating both forward and inverse design strategies, metasurfaces with planar geometry (≈1/5 of the operating wavelength), enhanced fabrication tolerance, and stable in-liquid operation are realized. These metasurfaces generate various structured light beams in water, including abruptly autofocusing (AAF) beams, Bessel beams, optical vortices, and Gaussian focusing beams. This work establishes a scalable and reliable platform for underwater nanophotonics and emerging IoUT-related applications.}, archive = {J_ADVS}, author = {Jia-Hua Lee and Hsing-Yi Wang and Pei Ying Ho and Yu Chia Chung and Ruei-Tzu Duh and Cheng-Ching Chiang and Ray-Hua Horng and Yao-Wei Huang and Ming Lun Tseng}, doi = {10.1002/advs.202510467}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e10467}, shortjournal = {Adv. Sci.}, title = {Water-immersed GaP huygens’ meta-optics for visible structured light generation}, volume = {12}, year = {2025}, }
• (2025). Bioactive siRNA-based liposomes promoted tendon-bone healing in osteoporotic mice by recovering the stemness of CD248+ TSPCs. ADVS, 12(34), e09883. (www)

  @article{ , abstract = {Osteoporosis significantly impairs tendon-bone healing, increasing the risk of rotator cuff tears and postoperative retearing. Tendon stem/progenitor cells (TSPCs) are vital for tendon repair, with their stemness crucial to healing outcomes. This study investigated the role of CD248 in regulating TSPC stemness and assessed the therapeutic potential of si-CD248-loaded liposomes in promoting tendon-bone healing under osteoporotic conditions. Single-cell RNA sequencing (scRNA-seq) identified increased TSPC populations, particularly a unique subcluster, TSPC-0, with elevated CD248 expression in osteoporotic tendon samples. CD248 + TSPCs displayed reduced proliferation, increased apoptosis, and impaired migration, driven by altered FAK-JAK-STAT1 signaling. si-CD248-loaded liposomes were formulated and characterized, demonstrating efficacy in inhibiting CD248 expression, restoring TSPC stemness, and promoting tendon-bone healing. In osteoporotic mice, liposome treatment significantly enhanced tissue regeneration, improving histological scores, collagen organization, and biomechanical properties. This study reveals that elevated CD248 expression negatively impacts TSPC stemness and impairs healing under osteoporotic conditions. Targeting CD248 using si-CD248-loaded liposomes effectively restores TSPC regenerative potential, representing a promising therapeutic strategy to enhance tendon-bone healing in osteoporotic patients.}, archive = {J_ADVS}, author = {Yinhua Qian and Jinguo Zhu and Yanwei He and Haocheng Qin and Pingkang Qian and Bingfeng Sun and Haoqiang Huang and Chen Kuang and Quan Yang and Yuxi Ou and Rong Sun and Feng Xu and Xianwen Wang and Zhiwen Luo and Qing Wang}, doi = {10.1002/advs.202509883}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e09883}, shortjournal = {Adv. Sci.}, title = {Bioactive siRNA-based liposomes promoted tendon-bone healing in osteoporotic mice by recovering the stemness of CD248+ TSPCs}, volume = {12}, year = {2025}, }
• (2025). CRISPR screening reveals a novel role for FOXH1 in regulating pluripotency of porcine embryonic stem cells. ADVS, 12(34), e09495. (www)

  @article{ , abstract = {Porcine extended potential stem cells (pEPSCs), which exhibit both self-renewal and pluripotency, are promising for application in both agricultural biotechnology and regenerative medicine. However, the molecular mechanisms governing these two interconnected properties remain elusive. Here, two types of CRISPR-Cas9 screenings are conducted in pEPSCs. This fitness screening identified several genes essential for cell viability, including PRMT1 , MYBL2 , and NASP . Concurrently, FACS-based screenings revealed genes crucial for pluripotency, such as SOX2 , ZFP42 , and FOXH1 . Notably, it is demonstrated that FOXH1 is required for maintaining pluripotency in pEPSCs, which complements the understanding of its role in mesendoderm specification. pEPSCs lacking FOXH1 exhibited a flatter and more dispersed clonal morphology, accompanied by downregulation of pluripotency genes and upregulation of lineage-specific genes. Additionally, FOXH1 knockdown significantly impaired blastocyst formation during early pig embryogenesis. Functionally, the dual role of FOXH1 in pluripotency maintenance and cell differentiation is validated: FOXH1 preserves pluripotency by enhancing chromatin accessibility at pluripotency gene loci, while also influencing lineage specification through H3K4me3 modification at developmental related genes. Thus, these findings uncover a novel role of FOXH1 involved in the core regulatory network that orchestrates gene expression programs to maintain the pluripotency state of pEPSCs and provide valuable insights into categorizing gene function.}, archive = {J_ADVS}, author = {Peng Su and Linhui Wu and Delong Li and Wenting Song and Dagang Tao and Liang Liu and Qi Wang and Manxin Gao and Tian Xu and Xin Liu and Shengsong Xie and Xia Zhang and Jilong Zhou and Yi-Liang Miao}, doi = {10.1002/advs.202509495}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e09495}, shortjournal = {Adv. Sci.}, title = {CRISPR screening reveals a novel role for FOXH1 in regulating pluripotency of porcine embryonic stem cells}, volume = {12}, year = {2025}, }
• (2025). Multifunctional chiral halide perovskites: Advancing chiro-optics, chiro-optoelectronics, and spintronics. ADVS, 12(34), e09155. (www)

  @article{ , abstract = {Chiral halide perovskites (CHPs) represent a revolutionary material class, integrating the exceptional optoelectronic properties of halide perovskites with chirality. This unique combination enables advanced functionalities in chiroptics, spintronics, and next-generation optoelectronics. Recent breakthroughs highlight CHPs’ capabilities in circularly polarized light (CPL) emission/detection, spin-selective charge transport, and nonlinear optical processes, establishing them as a focal point in multifunctional material research. This review provides an in-depth, device-centric analysis of the latest CHP technologies. Material design strategies, chirality induction/transfer mechanisms, scalable synthesis methods, and diverse device architectures are explored. Particular emphasis is placed on clarifying structure–property–performance relationships across applications, including CPL photodetectors, light-emitting diodes, lasers, second-harmonic generation devices, spintronic components, and neuromorphic optoelectronics. Additionally, CHPs’ potential for cutting-edge applications such as multimodal polarimetry, artificial intelligence, and secure information processing is examined. By defining design guidelines and performance benchmarks, this review aims to bridge the gap between academic research and practical technology translation. It not only synthesizes the current state-of-the-art but also outlines future directions for high-performance CHP devices, driving progress in this rapidly evolving field.}, archive = {J_ADVS}, author = {Qi Liu and Hui Ren and Qi Wei and Mingjie Li}, doi = {10.1002/advs.202509155}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e09155}, shortjournal = {Adv. Sci.}, title = {Multifunctional chiral halide perovskites: Advancing chiro-optics, chiro-optoelectronics, and spintronics}, volume = {12}, year = {2025}, }
• (2025). Rational design of advanced functional catalysts for photo-reforming glucose into bio-derived fuels and chemicals. ADVS, 12(34), e08850. (www)

  @article{ , abstract = {Transforming renewable biomass resources into high-value chemicals and energy-dense fuels has become paramount for advancing sustainable economic development toward a carbon-neutral society. Glucose, a key platform molecule for biomass, has attracted considerable research attention for its promise as a feedstock for the production of various biochemicals and biofuels. To achieve glucose conversion with enhanced selectivity and efficiency, it is critical to develop high-performance heterogeneous photocatalysts and fine-tune cascade catalytic processes. This review provides a systematic overview of recent progress in design of advanced functional catalysts for photo-reforming glucose into bio-derived fuels and a variety of bio-based molecules, with an emphasis on design and applications of functionalized heterogeneous photocatalysts, including material structure optimization strategies and their impacts on catalytic performance. Furthermore, this review covers key aspects such as reaction mechanism elucidation, product selectivity control, and reaction condition optimization, providing comprehensive insights into structure-activity relationships and functional modification strategies. Through a systematic analysis of the current research landscape, this review outlines the rational design principles for functional catalysts and the optimization strategies for catalytic processes. It aims to provide theoretical guidance for the development of efficient and stable photocatalytic systems and to offer new solutions to producing green chemicals/fuels and achieving carbon neutrality.}, archive = {J_ADVS}, author = {Qiong Yan and Yuyue Zhou and Yan Zhang and Dalin Sun and Xu Wu and Song Yang and Chunbao Xu and Heng Zhang}, doi = {10.1002/advs.202508850}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e08850}, shortjournal = {Adv. Sci.}, title = {Rational design of advanced functional catalysts for photo-reforming glucose into bio-derived fuels and chemicals}, volume = {12}, year = {2025}, }
• (2025). NOX2 contributes to high-frequency outer hair cell vulnerability in the cochlea. ADVS, 12(34), e08830. (www)

  @article{ , abstract = {Most patients with sensorineural hearing loss (SNHL) may initially experience high-frequency hearing loss linked to greater vulnerability of outer hair cells (OHCs) in the cochlear basal turn. However, the molecular mechanism underlying this susceptibility in the high-frequency region remains unclear. Here, NOX2 is first identified as a differentially expressed gene related to oxidative damage in the apical and basal turns through single-cell RNA sequencing. In mouse cochleae damaged by neomycin and noise, Nox2-positive OHCs increase progressively from the apex to base, indicating that NOX2 expression clearly differed significantly between the apical and basal OHCs. In NOX2 knockout mice, OHC damage caused by neomycin and noise exposure is significantly reduced. Furthermore, knocking out NOX2 increases the expression of Nrf2 in the cytoplasm and Nrf2 nuclear translocation in OHCs. In addition, Nrf2 inhibitors counteract the protective effect of NOX2 knockout against neomycin. Finally, when Nox2 is used as the target, ginsenoside Rg1 is identified as a compound with protective effects against neomycin-induced hearing loss. In summary, these results indicate NOX2 is highly correlated with high-frequency OHCs vulnerability in the cochlea and is a potential intervention target for the clinical treatment of SNHL.}, archive = {J_ADVS}, author = {Meihao Qi and Zejun Gao and Yang Qiu and Renfeng Wang and Keyong Tian and Bo Yue and Xinyu Zhang and Peng Zhang and Ziqi Wu and Qingwen Zhu and Zhenzhen Liu and Zhuoyao Ma and Xueying Zhou and Yu Han and Jun Chen and Jianhua Qiu and DingJun Zha}, doi = {10.1002/advs.202408830}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e08830}, shortjournal = {Adv. Sci.}, title = {NOX2 contributes to high-frequency outer hair cell vulnerability in the cochlea}, volume = {12}, year = {2025}, }
• (2025). Resolving the sodiation process in hard carbon anodes with nanostructure specific X-ray imaging. ADVS, 12(34), e08635. (www)

  @article{ , abstract = {Hard carbons show significant promise as anode materials for sodium-ion batteries. However, monitoring the sodiation process in the hard carbon electrode during cycling and understanding the sodiation mechanism remain challenging. This article reports on operando 2D scanning small- and wide-angle X-ray scattering (SWAXS) and ex situ 3D SAXS tomography of hard carbon electrodes during the sodiation process. Structural changes are monitored with spatial and temporal resolution during the electrochemical process and shows that sodiation through micropore filling is the more dominating mechanism in the later stages of sodiation, i.e. in the plateau region of the voltage profile, while intercalation occurs continuously. Spatial inhomogeneities are resolved over the electrode and reveal an increased level of inhomogeneity at higher degree of sodiation with regions of different degrees of micropore filling. Resolving the processes spatially shows that plating starts at the interface between the electrode and the current collector where also a high degree of micropore filling and formation of pseudo-metallic sodium is found. The work demonstrates how SWAXS imaging can contribute to understanding the sodiation of hard carbon anodes, not only by spatially resolved analysis, but as a method to decouple contributions from different components in a cell, enabling more accurate scattering analysis in in situ environments.}, archive = {J_ADVS}, author = {Martina Olsson and Antoine Klein and Nataliia Mozhzhukhina and Shizhao Xiong and Christian Appel and Mads Carlsen and Leonard Nielsen and Linnea Rensmo and Marianne Liebi and Aleksandar Matic}, doi = {10.1002/advs.202508635}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e08635}, shortjournal = {Adv. Sci.}, title = {Resolving the sodiation process in hard carbon anodes with nanostructure specific X-ray imaging}, volume = {12}, year = {2025}, }
• (2025). Advancing nitrate-to-ammonia electrocatalysis: Strategies in catalyst design, electrolyte engineering, and performance evaluation. ADVS, 12(34), e08614. (www)

  @article{ , abstract = {The electrochemical reduction of nitrate for ammonia production not only offers a promising alternative to the traditional Haber–Bosch process, which requires high temperatures and pressures, but also provides an effective solution to the pollution caused by nitrogen-enriched nutrients in drinking water and soil. Nitrate reduction is a complex multielectron, multiproton reaction, leading to multiple reaction pathways and numerous by-products. Moreover, the product distribution and Faradaic efficiency are highly dependent on the applied potential, often resulting in competing reactions, such as the hydrogen evolution reaction, which increase energy consumption. Therefore, the development of low-cost, highly active, highly selective, and scalable electrocatalysts for nitrate reduction is critical to advancing this field. This review highlights recent advances in nitrate reduction electrocatalysis, focusing on catalyst design strategies, reaction environments, and performance evaluation. It also compiles and analyzes a wide range of research examples in the field, discusses current challenges, and offers perspectives on future research directions. This review is aimed to serve as a guide for the rational design and development of nitrate reduction electrocatalysts and to accelerate progress in nitrogen cycle engineering.}, archive = {J_ADVS}, author = {Juan Bai and Ziyou Dong and Xudong Jiang and Qianqin Zhou and Jiahao Zhao and Jun Mei and Ziqing Tan and Ting Liao and Ziqi Sun}, doi = {10.1002/advs.202508614}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e08614}, shortjournal = {Adv. Sci.}, title = {Advancing nitrate-to-ammonia electrocatalysis: Strategies in catalyst design, electrolyte engineering, and performance evaluation}, volume = {12}, year = {2025}, }
• (2025). Highly efficient catalysis of sulfur reduction reaction: 3d10-based catalysts. ADVS, 12(34), e08473. (www)

  @article{ , abstract = {Lithium-sulfur batteries (LSBs), with their high energy density compared to lithium-ion batteries, are now strong candidates for next-generation energy storage systems. However, insufficient redox kinetics leads to shuttle effect and lithium dendrites, which hinder their commercial application. In this paper, the latest progress of 3d 10 -based materials such as copper, zinc and their composites as cathode materials for LSBs is discussed, and the kinetics of polysulfide reduction catalyzed by copper-zinc-based materials and the mechanism of restraining shuttle effect are discussed in detail. Several strategies for the rational design of 3d 10 -based catalysts to improve the polysulfide reduction reaction are summarized. Finally, we summarize the challenges faced by 3d 10 -based materials in LSBs applications and present an outlook to improve the reference for the design of next-generation LSBs materials.}, archive = {J_ADVS}, author = {Kangxin Chen and Haili Luo and Yuanyuan Chang and Daying Guo and Yuchuan Zhu and Longyang Zhou and Xi'an Chen and Shun Wang}, doi = {10.1002/advs.202508473}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e08473}, shortjournal = {Adv. Sci.}, title = {Highly efficient catalysis of sulfur reduction reaction: 3d10-based catalysts}, volume = {12}, year = {2025}, }
• (2025). Progress on the attenuation mechanism and modification of the cobalt-free spinel LiNi0.5Mn1.5O4. ADVS, 12(34), e08121. (www)

  @article{ , abstract = {Cobalt-free LiNi 0.5 Mn 1.5 O 4 (LNMO) has recently emerged as a highly promising cathode material owing to its benefits of a high operating voltage platform (≈4.7 V vs Li), high theoretical energy density (≈650 Wh kg −1 ), eco-friendliness, and resource abundance. However, it has also demonstrated low cycle and poor rate performances. Researchers have hitherto identified multiple LNMO failure and degradation mechanisms, including the Jahn-Teller effect, Transition Metal (TM) dissolution, electrolyte decomposition, and Oxygen Vacancies (OVs). The Jahn-Teller effect causes structural material degradation, while TM dissolution could lead to the loss of reactive species and interfacial side reactions. On the other hand, OVs and electrolyte decomposition accelerate capacity decay. Notably, deeply understanding LNMO structural failure mechanisms and the targeting of corresponding modifications presents a vital avenue for modulating its surface-interface structure and improving its electrochemical performance. Although researchers have extensively investigated the failure mechanisms of LNMO to elucidate its modification strategies, a comprehensive and detailed summary of the latest research advancements has yet to be provided. In this work, the research background, encompassing the advantages and disadvantages of LNMO cathode materials, is first introduced. The crystal structure and discharge mechanisms, among other fundamental principles of LNMO, are subsequently analyzed. Finally, recent research findings on the aforementioned failure mechanisms in high-voltage spinel LNMO are synthesized. Subsequently, a critical assessment of recent advancements in modification strategies targeting the failure mechanisms of LNMO is performed, encompassing the tools employed (e.g., doping modification, surface coating, morphology and size management, and surface orientation management) as well as their synergistic effects. Finally, potential future research directions to guide the rational design of high-performance LNMO, particularly manganese-based spinel cathode material, are proposed.}, archive = {J_ADVS}, author = {Bao Zhang and Zhen Liang and Peng Dong and Weili Song and Yiyong Zhang and Xue Li and Xiaoyuan Zeng and Yongkang Liu and Ziliang Feng and Enfeng Zhang and Yingjie Zhang and Yannan Zhang}, doi = {10.1002/advs.202508121}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e08121}, shortjournal = {Adv. Sci.}, title = {Progress on the attenuation mechanism and modification of the cobalt-free spinel LiNi0.5Mn1.5O4}, volume = {12}, year = {2025}, }
• (2025). Metamaterial-enhanced solar-driven processes for energy conversion and water treatment. ADVS, 12(34), e08046. (www)

  @article{ , abstract = {To address global challenges in sustainable energy and water treatment, metamaterials have emerged as a transformative class of materials for solar-driven photocatalysis. Through nanoscale engineering, these artificially structured materials enable precise manipulation of light–matter interactions and significantly enhance solar energy utilization beyond the limits of conventional photocatalysts. This review systematically summarizes recent progress in applying metamaterials to solar-driven processes for energy conversion and water treatment, including photocatalytic CO 2 reduction, water splitting for hydrogen generation, degradation of organic pollutants, and solar-driven water evaporation for purification. Key enhancement mechanisms include localized surface plasmon resonance, photonic bandgap engineering, and improved charge separation via metamaterial and semiconductor heterojunctions, which collectively improve light absorption, charge separation and transfer, and surface reactivity. Practical challenges related to scalable fabrication, long-term durability, and integration into real-world systems are also examined. Finally, emerging directions, including AI-assisted inverse design, structural chirality, and multifunctional hybrid architectures, are discussed as promising strategies to further advance metamaterial-based photocatalysts in sustainable energy and environmental applications.}, archive = {J_ADVS}, author = {Xuechen Jing and Zhehao Sun and Hang Yin and Kaili Liu and Yi-Lun Chen and Shuwen Cheng and Zongyou Yin}, doi = {10.1002/advs.202508046}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e08046}, shortjournal = {Adv. Sci.}, title = {Metamaterial-enhanced solar-driven processes for energy conversion and water treatment}, volume = {12}, year = {2025}, }
• (2025). Structure-function relationships of biomass-derived materials for zinc metal protection. ADVS, 12(34), e07768. (www)

  @article{ , abstract = {Aqueous zinc-ion batteries have attracted significant attention for large-scale energy storage applications, yet their practical implementation is fundamentally limited by zinc anode stability. This review first establishes a comprehensive understanding of zinc degradation mechanisms, revealing how ion transport, solvation dynamics, and electrical double layer structure collectively determine interfacial stability. The fundamental properties and protective mechanisms of biomass-derived materials are systematically analyzed, focusing on four key functional groups: carboxyl, amino, hydroxyl, and sulfonic acid. Through examining their roles in regulating critical interfacial processes, quantitative structure-function relationships are established that reveal optimal interface protection requires balanced binding energies rather than maximizing individual interactions. More significantly, it is demonstrated that spatial distribution and synergistic effects among multiple functional groups enable superior interface regulation beyond simple additive benefits. These molecular-level insights transform empirical additive selection into rational design principles. Critical challenges in mechanistic understanding, scalability, and standardization are identified, proposing strategic directions for advancing zinc-based energy storage technologies.}, archive = {J_ADVS}, author = {Qiwei Gao and Zhuo Chen and Ya He and Zhangxiang Hao and Junrun Feng}, doi = {10.1002/advs.202507768}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e07768}, shortjournal = {Adv. Sci.}, title = {Structure-function relationships of biomass-derived materials for zinc metal protection}, volume = {12}, year = {2025}, }
• (2025). CsPbBr3 perovskite-based heterostructures in photocatalysis: Mechanisms, stability, and multifunctional performance. ADVS, 12(34), e07747. (www)

  @article{ , abstract = {CsPbBr 3 perovskite stands out as a promising photocatalyst due to its strong visible-light absorption and advantageous band positions, yet its practical application is constrained by rapid charge recombination and poor aqueous stability. This review systematically explores how heterostructure engineering, which encompasses Type-II, Z-scheme, and S-scheme architectures, overcomes these limitations by optimizing interfacial charge dynamics and enhancing material durability. The underlying mechanisms of band alignment, charge transfer pathways, and redox potential retention in heterostructures, alongside strategies for activity modulation and stability enhancement are analyzed. By integrating insights from structural design to functional performance, the review illuminates how CsPbBr 3 -based heterostructures address critical challenges in photocatalysis, offering a comprehensive framework for advancing sustainable solutions in energy conversion and environmental remediation.}, archive = {J_ADVS}, author = {Kuanxin Lv and Zhenzhen Li and Xing Huang and Zetong Cheng and Zhongyan Wang and Hang Zhao}, doi = {10.1002/advs.202507747}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e07747}, shortjournal = {Adv. Sci.}, title = {CsPbBr3 perovskite-based heterostructures in photocatalysis: Mechanisms, stability, and multifunctional performance}, volume = {12}, year = {2025}, }
• (2025). A nano-electro-platform enabling evolutionary screening and remodeling of tumor cells for metastasis inhibition. ADVS, 12(34), e07684. (www)

  @article{ , abstract = {Tumor metastasis remains the leading cause of mortality among cancer patients. Addressing this challenge necessitates the development of effective strategies for targeted drug delivery and therapy. Given that metastatic lesions are primarily driven by highly aggressive tumor cell subpopulations, in-depth study of these cells and further guiding design of targeted therapeutics, play deterministic roles in metastasis inhibition. Herein, a nano-electro-platform is shown that enables non-invasive screening of aggressive cell subpopulations from heterogeneous tumor samples. Single-cell sequencing further reveals immune evasion pathways associated with their aggressive behavior. Targeting the screened aggressive cells, the platform implements a unique nanopore-focused electric field, which genetically remodels the cells to generate extracellular vesicles (EVs) with significantly enhanced tumor-targeting and therapeutic capabilities. The engineered EVs effectively activate macrophages and T cells, leading to robust tumor cell elimination and metastasis inhibition in lung cancer metastasis models. These highlight a versatile, multidisciplinary technique adopting a new path toward deep understanding and treating metastasis.}, archive = {J_ADVS}, author = {Feng Liu and Hong Sun and Bing Liu and Jing Zhang and Chengbao Wu and Shi Yan and Chengzheng Tai and Yihang Tong and Rongtai Su and Xiaowei Xiang and Han Wu and Fuqi Yao and Kuan Yang and Dedong Yin and Yuqiong Wang and Ao Xiao and Long Cheng and Xi Chen and Nan Wu and Zaizai Dong and Lingqian Chang}, doi = {10.1002/advs.202507684}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e07684}, shortjournal = {Adv. Sci.}, title = {A nano-electro-platform enabling evolutionary screening and remodeling of tumor cells for metastasis inhibition}, volume = {12}, year = {2025}, }
• (2025). Magnetically controllable and degradable milliscale swimmers as intraocular drug implants. ADVS, 12(34), e07569. (www)

  @article{ , abstract = {Intraocular drug implants are increasingly used for retinal treatments, such as age-related macular degeneration and diabetic macular edema, due to the rapidly aging global population. Although these therapies show promise in arresting disease progression and improving vision, intraocular implant-based therapies can cause unexpected complications that require further surgery due to implant dislocation or uncontrolled drug release. These frequent complications of intraocular drug implants can be overcome using magnetically controllable degradable milliscale swimmers (MDMS) with a double-helix body morphology. A biodegradable hydrogel, polyethylene glycol diacrylate, is employed as the primary 3D printing material of MDMS, and it is magnetized by decorating it with biocompatible polydopamine-encapsulated iron-platinum nanoparticles. MDMS have comparable dimensions to commercial intraocular implants that achieve translational motions in both aqueous and vitreous bodies. They can be imaged in real-time using optical coherence tomography, ultrasound, and photoacoustic imaging. Thanks to their biodegradable hydrogel-based structure, they can be loaded with anti-inflammatory drug molecules and release the medications without disrupting retinal epithelial viability and barrier function, and decrease proinflammatory cytokine release significantly. These magnetically controllable swimmers, which degrade in a couple of months, can be used for less invasive and more precise intraocular drug delivery compared to commercial intraocular drug implants.}, archive = {J_ADVS}, author = {Erdost Yildiz and Ugur Bozuyuk and Eray Yildiz and Fan Wang and Mertcan Han and Alp Can Karacakol and Devin Sheehan and Yan Yu and Metin Sitti}, doi = {10.1002/advs.202507569}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e07569}, shortjournal = {Adv. Sci.}, title = {Magnetically controllable and degradable milliscale swimmers as intraocular drug implants}, volume = {12}, year = {2025}, }
• (2025). LncRNA foxo6os as a novel “ scaffold” mediates MYBPC3 in combating pathological cardiac hypertrophy and heart failure. ADVS, 12(34), e07365. (www)

  @article{ , abstract = {Heart failure (HF) as the terminal stage of various cardiac diseases, its underlying molecular mechanisms still remain elusive. Emerging evidence have implicated long noncoding RNAs (lncRNAs) play a multifaceted role in the progression of cardiac hypertrophy and HF. Here, it is identified that a lncRNA forkhead box O6, opposite strand (Foxo6os) is significantly downregulated in murine HF model induced using transverse aortic constriction (TAC). Knockdown of Foxo6os accelerates cardiomyocyte hypertrophy, reflects as elevated expression of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and myosin heavy chain 7 (MYH7). Conversely, Foxo6os overexpression can improve cardiac function and alleviate adverse cardiac remodeling. Mechanistically, Foxo6os directly interacts with myosin-binding protein-C (MYBPC3), which then recruits protein kinase C alpha (PKC-α) to facilitate MYBPC3 phosphorylation, resulting in maintaining myocardial contractility and postponing HF progression. Therefore, these findings underscore the critical role of Foxo6os in preserving cardiomyocyte contractile function, suggesting a potential for Foxo6os as a novel therapeutic target of HF.}, archive = {J_ADVS}, author = {Jie Sheng and Qin Lin and Yizhuo Sun and Yilei Meng and Sangyu Hu and Huaming Cao and Fang Lin and Yuping Zhu and Luying Peng and Li Li}, doi = {10.1002/advs.202507365}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e07365}, shortjournal = {Adv. Sci.}, title = {LncRNA foxo6os as a novel “ scaffold” mediates MYBPC3 in combating pathological cardiac hypertrophy and heart failure}, volume = {12}, year = {2025}, }
• (2025). Atypical hydrogen bond interaction enables anion-rich solvation structure in polymer electrolytes for high-voltage flexible lithium metal batteries. ADVS, 12(34), e07007. (www)

  @article{ , abstract = {Flexible lithium metal batteries (LMBs) using polymer-based solid-state electrolytes (PSSEs) are highly desirable for wearable applications because of the potential advantages in energy density and safety. Recently, ether-based polyelectrolytes have received extensive attention because of their good stability, high ionic conductivity, and Li metal anode compatibility. However, it typically forms organic-rich cathode electrolyte interphase (CEI) at the cathode, which is still a pain point that impedes the high-voltage performance. To address this challenge, herein a fluorinated plasticizer, bis(2-fluoroethyl) ether (BFE) is reported, which can be easily blended into ether-based PSSE and enables high-voltage-stable flexible LMBs. The BFE and PSSE molecules form an atypical hydrogen bond interaction, which weakens the interaction between PSSE and lithium ions. This leads to the formation of an anion-rich solvation structure that generates inorganic-rich and high-voltage-stable CEI. The oxidation stability of PSSE is improved from 4.4 V to over 4.7 V after introducing the BFE molecules. LMBs using BFE-blended PSSE can couple with high-voltage cathode and retain 80% capacity after 480 cycles at 1C. Full cells show high energy density (752.2 Wh L −1 ) outstanding capacity retention per cycle (99.88%), and high flexibility with almost identic charge/discharge characteristics after 4000 bending cycles.}, archive = {J_ADVS}, author = {Shujing Wen and Junhua Zhou and Guangzhao Zhang and Qingrong Wang and Chao Luo and Ruo Wang and Pengxian Li and Chaoyang Wang and Xiaoxiong Xu and Yonghong Deng and Jian Chang and Zijian Zheng}, doi = {10.1002/advs.202507007}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e07007}, shortjournal = {Adv. Sci.}, title = {Atypical hydrogen bond interaction enables anion-rich solvation structure in polymer electrolytes for high-voltage flexible lithium metal batteries}, volume = {12}, year = {2025}, }
• (2025). A study of skeletal stem cell dynamics and its potential applications in the design of a titanium implant for senile osteoporosis. ADVS, 12(34), e06982. (www)

  @article{ , abstract = {Traditional biomaterial design often prioritizes empirical knowledge over disease mechanisms and pathological dynamics, resulting in imprecise solutions in complex clinical conditions. Age-related osteoporosis (A-OP) is a disease associated with aging, characterized by a dysfunctional pathological microenvironment that hinders the osseointegration of conventional titanium implants. To develop a targeted titanium implant for A-OP, rat single-cell transcriptomics is integrated with human serum-derived transcriptome data to investigate dynamic changes in skeletal stem cells (SSCs) during aging, which guided the implant design. These findings reveal that hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) within SSCs interact via a feedback loop: HSCs undergo premature senescence, leading to depletion of HSCs and secondary senescence of MSCs. Senescent MSCs exhibit adipogenic bias, perpetuating the pathological cycle of A-OP. Using core genes identified in the transcriptome analyses, resveratrol is selected and utilized it and a GelMA-chitosan hydrogel to decorate titanium implants for localized delivery. In the A-OP microenvironment, the hydrogel enables sustained responsive release of resveratrol, which reverses MSC senescence and redirects differentiation from adipogenic to osteogenic lineages, thereby breaking the pathological cycle. This multi-omics-driven implant design enhances precision and offers a novel methodology for biomaterial development.}, archive = {J_ADVS}, author = {Wuzhe Fan and Tao Zheng and Mingsong Mao and Pengfei Gao and Yulu Yang and Rong Wang and Yao Yang and Yangpeng Zuo and Tiantian Yuan and Ruqing Bai and Weihu Yang and Xingchen Yan and Kaiyong Cai}, doi = {10.1002/advs.202506982}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06982}, shortjournal = {Adv. Sci.}, title = {A study of skeletal stem cell dynamics and its potential applications in the design of a titanium implant for senile osteoporosis}, volume = {12}, year = {2025}, }
• (2025). Superelastic fire-safe aerogel with hierarchical structures via dual templates aided by microbubble engineering. ADVS, 12(34), e06808. (www)

  @article{ , abstract = {Superelastic aerogels with ultralow thermal conductivity have essential advantages for advanced thermal management systems in energy-efficient buildings. However, inorganic aerogels suffer from brittleness and poor processability, whereas their organic counterparts experience high production costs and inadequate elastic recovery. This study used a dual-template (ice and bubble) strategy to fabricate ultralight, superelastic aerogels with hierarchical porosity inspired by stress-dissipating dome architectures. Microbubbles are engineered via a modified “Tessari method” to create macropores (≈100 µm) while ice-templating introduced aligned pores of a few µm in size during freeze-drying. The synergistic interplay of a rigid gelatine (Ge) skeleton, flexible polyvinyl alcohol (PVA) nodes, and potassium salt-enhanced crystalline domains yielded aerogels with exceptional elasticity, ultralow density and thermal conductivity. Flame retardancy is achieved through potassium salt-mediated catalytic carbonization, reducing the peak heat release rate by 54% and enabling self-extinguishing behavior. Microbubble introduction in precursors can provide macropores for aerogels, which dispersed internal stress during the deformation of aerogel, whereas dynamic hydrogen bonds enabled rapid water-assisted self-healing ability and closed-loop recyclability. Scalable production using commercial compressed air foaming systems and a low raw material cost further highlight its industrial viability. Combined with biodegradability and superior thermal insulation, this work advances sustainable, fire-safe aerogels for multifunctional applications.}, archive = {J_ADVS}, author = {Xiaoyang Yu and Huan Li and Ning Kang and Shouxiang Lu and Mingjun Xu and Man Pun Wan}, doi = {10.1002/advs.202506808}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06808}, shortjournal = {Adv. Sci.}, title = {Superelastic fire-safe aerogel with hierarchical structures via dual templates aided by microbubble engineering}, volume = {12}, year = {2025}, }
• (2025). An osteoconductive janus hydrogel with full barrier protection and adaptable degradation properties for superior bone regeneration. ADVS, 12(34), e06736. (www)

  @article{ , abstract = {Implant materials for bone regeneration necessitate a barrier function to block bacterial adhesion and fibroblast infiltration, while maintaining a delicate equilibrium between material degradation and osteogenesis. Here, a spatiotemporally and hierarchically-guided bone regeneration hydrogel with a Janus structure is engineered through a sequential photocuring protocol, which features full barrier protection by the outer dense phase and superior osteoconductivity within the inner loose phase. The Janus hydrogel exhibits stable spatiotemporal layering, adaptable degradation, asymmetrical combination of network structures, and mechanical strength. The dense phase, with space maintenance capacity, completely covers the defective area, continuously blocking fibroblast infiltration, and preventing bacterial adhesion. In addition, the loose phase is shape-adapted to the defective cavity, allowing osteoblast-associated cells to migrate and create a favorable osteogenic microenvironment. In situ implantation of this Janus hydrogel effectively promoted osteogenesis, angiogenesis, and neurogenesis in both mouse calvarial and rat periodontal bone defect models. Furthermore, the osteogenic efficiency achieved by the Janus hydrogel implanted in mouse calvarial defects and rat periodontal defects is increased by 42% and 13.7%, respectively, as compared with previous studies. These findings thus demonstrated the synergy of protective barrier function, osteoconductive properties, and adaptive degradation within a single scaffold, which is conducive to bone regeneration.}, archive = {J_ADVS}, author = {Yanhui Lu and Jia Song and Yongle Lv and Boon Chin Heng and Mingming Xu and Ying He and Youde Liang and Lu-Ning Wang and Tingting Wu and Ting Song and Tingjun Li and Qiaomei Ren and Lei Wang and Xuliang Deng and Xuehui Zhang}, doi = {10.1002/advs.202506736}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06736}, shortjournal = {Adv. Sci.}, title = {An osteoconductive janus hydrogel with full barrier protection and adaptable degradation properties for superior bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Spatiotemporal adaptations-driven dynamic thra activation simulates a skin wound healing response. ADVS, 12(34), e06651. (www)

  @article{ , abstract = {The evolutionary adaptation of skin repair drives sequential regenerative phases: epidermal proliferation rapidly restores barrier function, followed by dermal reconstruction through extracellular matrix remodeling to establish structural support, yet the molecular coordination of this spatiotemporal program remains unclear. While the endocrine system is crucial in modulating wound repair, the critical hormone receptors orchestrating tissue-layer-specific responses are unidentified. Here, bulk and single-cell RNA sequencing, spatial transcriptomics, and in vivo/in vitro analyses in mouse models of hyperthyroidism and hypothyroidism, as well as wound and skin organoid models, are employed to identify the thyroid hormone receptor Thra as a key regulator of phase-coupled regeneration through two distinct yet coordinated mechanisms. In the initial phase, epidermal Thra activates glutathione metabolism via Gamma-Glutamylcyclotransferase (GGCT), driving keratin filament assembly to accelerate reepithelialization. In the subsequent phase, dermal Thra mediates the Serum Amyloid A3 (SAA3)-Fibronectin 1 (FN1) interaction, establishing angiogenic niches essential for matrix maturation. Using the self-assembled epidermis-dermis dynamic skin organoid model, Thra's role in simulating the wound healing process is further confirmed. This study highlights the essential role of spatiotemporal adaptability in wound repair using Thra as a paradigm and provides insights for developing clinical strategies to enhance skin wound healing.}, archive = {J_ADVS}, author = {Zeming Li and Jiajun Tan and Chuqing Zhou and Siyi Zhou and Yuanli Ye and Xinzhu Li and Xinyu Shen and Tian Xie and Mengyue Wang and Jingwei Jiang and Yiping Zhao and Xiao Xiang and Yong Zhou and Jun Wu and Cheng-Ming Chuong and Mingxing Lei}, doi = {10.1002/advs.202506651}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06651}, shortjournal = {Adv. Sci.}, title = {Spatiotemporal adaptations-driven dynamic thra activation simulates a skin wound healing response}, volume = {12}, year = {2025}, }
• (2025). Engineering adenine deaminase TadA for precise and PAM-flexible point mutagenesis and gradient-tuning endogenous protein design. ADVS, 12(34), e06644. (www)

  @article{ , abstract = {Base editing enables precise nucleotide substitutions within a relatively broad editing window (5–6 nucleotides). However, considerable bystander editing significantly compromise its accuracy. Point mutagenesis, a powerful approach for gradient-tuning protein function, facilitates the generation of diverse plant phenotypes to meet the demands of complex environments and consumer preferences. Here, a series of plant base editors is engineered by fusing three optimized TadA8e variants, TadA9, TadA-LM, and TadA-dual, with a PAM-flexible SpRY nickase (SpRYn, with 5′-NNN PAM recognition). These editors enable A-to-G, C-to-T, and dual-base (simultaneous A-to-G and C-to-T) conversions within a highly condensed active window (1–3 nucleotides). Performance evaluations reveal that the TadDBE (TadA Dual-Base Editor) achieves the most robust outcomes, delivering dual-base editing efficiencies ranging from 2.3% to 61.4%, while maintaining minimal off-target activity. Utilizing TadDBE, targeted point mutagenesis is performed on OsBadh2 , a gene encoding betaine aldehyde dehydrogenase that plays a critical role in the biosynthesis of 2-acetyl-1-pyrroline (2-AP), a key aromatic compound. This approach yields rice lines exhibiting gradient-tuned aromatic profiles and optimized levels of 2-AP and γ-aminobutyric acid (GABA). These evolved TadA-derived editors provide a precise, PAM-flexible platform for base editing and represent a versatile strategy for generating genome-edited plants with gradient-tuned agronomic traits.}, archive = {J_ADVS}, author = {Kangli Sun and Si Cheng and Nan Chai and Jianing Mi and Ruixiang Zhang and Qian Qian and Zhiye Zheng and Ke Chen and Dongchang Zeng and Xin Peng and Mengyuan Shen and Degui Zhou and Qinlong Zhu and Qi Liu and Jiantao Tan}, doi = {10.1002/advs.202506644}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06644}, shortjournal = {Adv. Sci.}, title = {Engineering adenine deaminase TadA for precise and PAM-flexible point mutagenesis and gradient-tuning endogenous protein design}, volume = {12}, year = {2025}, }
• (2025). Modulated interactions induced by cyano-modified wide-bandgap small-molecule acceptors enables high-performance ternary organic photovoltaics. ADVS, 12(34), e06606. (www)

  @article{ , abstract = {The cyano group is extensively employed in the molecular engineering of high-performance small-molecule acceptors (SMAs) for organic solar cells (OSCs) to fine-tune energy levels and optimize molecular packing. To date, the application of cyano group has predominantly been confined to end-group modification in SMAs, with limited investigation in central unit engineering. Herein, in this work, the role of cyano substitution is systematically investigated in the central unit of SMAs and design a novel cyano-functionalized wide-bandgap acceptor UF-BCN. The introduction of the cyano group significantly enhances the surface energy of the molecule and substantially deepens the highest occupied molecular orbital (HOMO) energy level due to its strong electron-withdrawing capability, then leading to a blue-shifted absorption. When introduced as the third component in the D18:BTP-eC9, UF-BCN demonstrates complementary light absorption, strong intermolecular interactions, and excellent compatibility with BTP-eC9 to form a mixed acceptor phase, enabling it to function as an effective morphological modulator within the ternary system. Consequently, the ternary OSC based on D18:BTP-eC9:UF-BCN achieves an impressive power conversion efficiency (PCE) of 19.34%. This study underscores the effectiveness of cyano substitution in central unit engineering and highlights its potential for optimizing active layer morphology and enhancing the performance of ternary OSCs.}, archive = {J_ADVS}, author = {Yuanyuan Zhang and Shijie Cheng and Meijia Chang and Lei Wang and Huanhuan Gao and Zirui Wang and Guanghao Lu and Shengmin Gan and Xinbo Lv and Jin Wang and Qingqing Sun and Mingjun Niu and Zichao Shen and Zhijun Wu and Cao Yang and Xuying Liu and Lingxian Meng}, doi = {10.1002/advs.202506606}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06606}, shortjournal = {Adv. Sci.}, title = {Modulated interactions induced by cyano-modified wide-bandgap small-molecule acceptors enables high-performance ternary organic photovoltaics}, volume = {12}, year = {2025}, }
• (2025). Peptide hormone-mediated regulation of plant development and environmental adaptability. ADVS, 12(34), e06590. (www)

  @article{ , abstract = {Peptide hormones are essential signaling molecules in plants, playing critical roles in regulating growth and development, stress responses, and crop genetic improvement. However, the full extent of their functions, functional redundancy among different peptide hormones, signaling mechanisms between ligand and receptor pathways, and peptide hormones-mediated regulation of plant development and environmental adaptability are still not fully understood. In this study, recent advances in understanding the formation and functions of plant peptide hormones, distinguishing between non-secretory and secretory peptides and their respective physiological roles are reviewed. These peptide hormones interact intricately with receptor kinases to regulate multiple signal transduction pathways. Plant peptide hormones are involved in cell proliferation and differentiation within both shoot apical and root apical meristems, as well as in the development of various organs. They also play a central role in plant reproduction, particularly in coordinating male-female gametophyte interactions for successful fertilization. Furthermore, plant peptide hormones contribute to abiotic stress responses and immune responses against biotic stresses. An overview of the multifaceted roles of plant peptide hormones in growth, development, and environmental adaptability, emphasizing their importance in plant biology are presented. Understanding the complex functions of these peptide hormones lays the foundation for developing strategies to enhance crop resilience and productivity.}, archive = {J_ADVS}, author = {Xin Li and Liping Zhu and Huiqin Wang and Xin Zhou and Manhong Wang and Libei Li and Feng Liu and Jie Sun and Guanghui Xiao}, doi = {10.1002/advs.202506590}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06590}, shortjournal = {Adv. Sci.}, title = {Peptide hormone-mediated regulation of plant development and environmental adaptability}, volume = {12}, year = {2025}, }
• (2025). Topographical patterning of cell-repellent interfaces for immune-stealth implantable electronics via multiphoton ablation lithography. ADVS, 12(34), e06482. (www)

  @article{ , abstract = {Stable and reliable operation of implantable electronics must ensure both high-quality electrical performance and chronic biocompatibility. Here, immune-stealth implantable electronics fabricated by multiphoton ablation lithography are introduced. The cell-repellent interface, consisting of micro-grooves and nano-islands, can be created by laser-assisted topography patterning on a thin film substrate. This patterned surface demonstrates a 20-fold increase in cell-repellent effectiveness against immune cells such as macrophages and fibroblasts due to disturbance of focal adhesion. Furthermore, the cell-repellent interface can also be patterned on the sub-micron electrode layer without compromising its electrical and electrochemical performance. When the electrocardiogram (ECG) sensor applying the cell-repellent interface is implanted into a rat subcutaneous tissue, inflammation and fibrotic reactions are effectively suppressed for 6 weeks. Consequently, stable ECG readings with clear PQRST waveforms are obtained in real-time for 4 weeks, suggesting its potential to enhance chronic biocompatibility of implantable electronics.}, archive = {J_ADVS}, author = {Hyunseon Seo and Gwan-Jin Ko and Sangmin Song and Joong Hoon Lee and Youngmin Seo and Sungkeun Han and Chan-Hwi Eom and Hyewon Kim and Seongsoo Kim and Kang-Sik Lee and Yu-Chan Kim and Hojun Kim and Si-Eun Moon and Kyungwoo Lee and Seung Hwan Ko and Suk-Won Hwang and Hojeong Jeon}, doi = {10.1002/advs.202506482}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06482}, shortjournal = {Adv. Sci.}, title = {Topographical patterning of cell-repellent interfaces for immune-stealth implantable electronics via multiphoton ablation lithography}, volume = {12}, year = {2025}, }
• (2025). MGPT: A multi-task graph prompt learning framework for drug discovery. ADVS, 12(34), e06444. (www)

  @article{ , abstract = {Predicting accurate drug associations, including drug-target interactions, drug side effects, and drug-disease relationships, is crucial in biomedical research and precision medicine. Recently, the research community is increasingly adopted graph representation learning methods to investigate drug associations. However, translating advancements in graph pre-training to the domain of drug development faces significant challenges, particularly in multi-task learning and few-shot scenarios. A unified Multi-task Graph PrompT (MGPT) learning model is proposed providing generalizable and robust graph representations for few-shot drug association prediction. MGPT constructs a heterogeneous graph network using different entity pairs as nodes and utilizes self-supervised contrastive learning of sub-graphs in pre-training. For downstream tasks, MGPT employs learnable functional prompts, embedded with task-specific knowledge, to enable robust performance across a range of tasks. MGPT demonstrates the ability of seamless task switching and outperforms competitive approaches in few-shot scenarios. MGPT emerges as a robust solution to the complexities of multi-task learning and the challenges associated with limited data in drug development.}, archive = {J_ADVS}, author = {Yang Li and Youhan Sun and Xinyu Qin and Xin Gao and Guohua Wang}, doi = {10.1002/advs.202506444}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06444}, shortjournal = {Adv. Sci.}, title = {MGPT: A multi-task graph prompt learning framework for drug discovery}, volume = {12}, year = {2025}, }
• (2025). Electrochemiluminescence discloses active intermediates in oxygen evolution reactions of Metal–Organic framework. ADVS, 12(34), e06309. (www)

  @article{ , abstract = {In situ disclosure about the complex four-electron transfer of anodic oxygen evolution reaction (OER) is crucial to further optimization of electrocatalysts. However, tracing the formation and evolution of unstable intermediates remains challenging. Here, electrochemiluminescence (ECL) analysis and imaging technique are developed to in situ monitor the important intermediate hydrogen peroxide intermediate (OOH*) on transition-metal-based 7,7,8,8-tetracyanoquinodimethane (TM─TCNQ) metal–organic framework materials as OER catalysts. Thanks to the highly selective ECL probe L-012 to OOH*, the ECL signal evolution (e.g., onset ECL potential and maximal ECL intensity) is bridged with the generation and accumulation of OOH*, allowing for convenient and quick judgment to the rate-determining step of OER. Due to the spatial and temporal resolution of ECL microscopy, it is found that the phase I of Cu─TCNQ shows better catalytic activity. The COMSOL simulation also shows the heterogeneous current distribution during the OER reaction, in agreement with ECL imaging results. Finally, the ECL approach enables to compare the OER performance of three TM─TCNQ, well explaining the free energy profiles for different reaction intermediates. Therefore, the proposed ECL analysis and microscopy provide an alternative way to understand the detailed elemental steps in OER, thus further indicating the direction for high-performance catalysts.}, archive = {J_ADVS}, author = {Xuan Chen and Bing-Xin Sun and Wei Xu and Chen-Hui Yin and Shi-Yi Zhou and Yi-Han Qian and Lu-Nan Zhang and Qin Xu and Huan Pang and Cheng Ma}, doi = {10.1002/advs.202506309}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06309}, shortjournal = {Adv. Sci.}, title = {Electrochemiluminescence discloses active intermediates in oxygen evolution reactions of Metal–Organic framework}, volume = {12}, year = {2025}, }
• (2025). Harnessing machine learning to enhance transition state search with interatomic potentials and generative models. ADVS, 12(34), e06240. (www)

  @article{ , abstract = {Transition state (TS) search is crucial for illuminating chemical reaction mechanisms but remains the major bottleneck in automated discovery because of the high computational cost. Recently, machine learning interatomic potentials (MLIPs) and generative models have shown promise in accelerating TS search, but their comparative strengths and limitations remain unclear. In this study, the first systematic and rigorous benchmarking framework is established to evaluate the effectiveness of ML methods in TS search, enabling a standardized and application-relevant assessment of their performance. Using an end-to-end TS search workflow, seven representative MLIPs are benchmarked alongside React-OT, a state-of-the-art generative model. These results demonstrate that pre-trained foundation MLIPs frequently fall short in reliably localizing TSs without task-specific fine-tuning. Furthermore, traditional energy and force metrics alone do not reliably predict TS search success, underscoring the need for more tailored evaluation criteria. Notably, with the same graph neural network architecture, React-OT frequently outperforms its MLIP counterpart, highlighting the potential of generative approaches for TS discovery. This benchmark serves as a critical foundation for the development and evaluation of future ML methods in chemical reactions, offering guidance for improving their generalizability and reliability in reactive chemistry.}, archive = {J_ADVS}, author = {Qiyuan Zhao and Yunhong Han and Duo Zhang and Jiaxu Wang and Peichen Zhong and Taoyong Cui and Bangchen Yin and Yirui Cao and Haojun Jia and Chenru Duan}, doi = {10.1002/advs.202506240}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06240}, shortjournal = {Adv. Sci.}, title = {Harnessing machine learning to enhance transition state search with interatomic potentials and generative models}, volume = {12}, year = {2025}, }
• (2025). SGCD: High-resolution spatial domain characterization via data interpolation and cell-type deconvolution. ADVS, 12(34), e06176. (www)

  @article{ , abstract = {The rapid advancement of spatial transcriptomics has provided a critical data foundation for the high-resolution characterization of tissue spatial domains. Traditional methods for spatial domain identification primarily rely on gene expression data from sampled spots in low-resolution spatial transcriptomic data, often overlooking valuable information between spots that can be crucial for domain identification. Furthermore, these methods are limited by their focus on gene expression data from neighboring spots, without fully integrating prior knowledge of cell types within the tissue's spatial structure. To address these challenges, SGCD, a novel method for tissue spatial domain identification based on data interpolation and cell type deconvolution is proposed. SGCD utilizes interpolation techniques to estimate gene expression data for cells in the gaps between spots and applies deconvolution to extract cell type information from both spots and interstitial regions. By integrating gene expression, cell type, and spatial location data, SGCD achieves accurate delineation of complex spatial domains through graph contrastive learning. Evaluations on various publicly available datasets, including the human dorsolateral prefrontal cortex, mouse brain, pancreatic ductal adenocarcinoma, and breast cancer, demonstrate that SGCD significantly outperforms existing methods in both accuracy and detail, offering strong support for advancing the understanding of tissue functions and disease mechanisms.}, archive = {J_ADVS}, author = {Tianjiao Zhang and Shenghe Li and Ruolan Zhang and Hongfei Zhang and Zhongqian Zhao and Hao Sun and Zhenao Wu and Guohua Wang}, doi = {10.1002/advs.202506176}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06176}, shortjournal = {Adv. Sci.}, title = {SGCD: High-resolution spatial domain characterization via data interpolation and cell-type deconvolution}, volume = {12}, year = {2025}, }
• (2025). Radiomics-based unsupervised clustering identifies subtypes associated with prognosis and immune microenvironment in clear cell renal cell carcinoma: A multicenter study. ADVS, 12(34), e06165. (www)

  @article{ , abstract = {Clear cell renal cell carcinoma (ccRCC) exhibits marked clinical heterogeneity, limiting the prognostic accuracy of traditional staging. We developed an unsupervised radiomics-based subtyping system integrating multi-omics data to decode tumor biology and improve risk stratification. Analyzing five cohorts (n = 1700, including surgical cohorts and an advanced ccRCC cohort receiving combined tyrosine kinase inhibitor and immunotherapy [T-I] treatment), we extracted 1834 CT radiomic features, applying consensus clustering to a discovery cohort (n = 748) and validating across centers. Two subtypes emerged with distinct recurrence risks: Cluster 1 and Cluster 2 (adjusted HR = 2.75 for recurrence, 95% CI 1.42–5.33, P = 0.003). Cluster 2’s high recurrence risk was validated in three external cohorts (adjusted HRs: 1.76, 4.33, and 3.09; all P < 0.05). Radiogenomic analysis revealed Cluster 2 showed a higher frequency of VHL mutations and KDM5C mutations compared to Cluster 1, a more immunosuppressive microenvironment (reduced CD8+ T cell infiltration, P < 0.01; suppressed interferon signaling pathways, Gene Set Enrichment Analysis P < 0.05), and lower PD-L1 expression. In the T-I treated advanced ccRCC cohort, Cluster 2 patients had shorter overall survival. This first unsupervised radiomic system stratifies ccRCC by recurrence risk, molecular drivers, and treatment efficacy, offering a framework for precision oncology.}, archive = {J_ADVS}, author = {Yusheng Guo and Bingxin Gong and Yi Li and Jie Lou and Shuai Shan and Xiaodong Zhang and Qiang Lu and Dongyong Zhu and Qing Sun and Lianwei Miao and Yuanxi Li and Yu-Dong Zhang and Wei Tan and Lian Yang and Chuansheng Zheng}, doi = {10.1002/advs.202506165}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e06165}, shortjournal = {Adv. Sci.}, title = {Radiomics-based unsupervised clustering identifies subtypes associated with prognosis and immune microenvironment in clear cell renal cell carcinoma: A multicenter study}, volume = {12}, year = {2025}, }
• (2025). Design and synthesis of core-shell nanospheres composed of heterostructured V2O5-CeVO4 toward efficient zn-ion storage. ADVS, 12(34), e05993. (www)

  @article{ , abstract = {The development of suitable cathode materials is a major scientific challenge for aqueous Zn-ion batteries (AZIBs). Although vanadium oxides have demonstrated encouraging results, challenges such as sluggish reaction kinetics and severe capacity decay caused by unstable crystal structure and vanadium dissolution still hinder their further application. Herein, Ce-glycerate nanospheres are used as a self-engaged template to construct core-shell nanospheres composed of heterostructured V 2 O 5 -CeVO 4 (denoted as VO-CeVO) by an anion-exchange strategy. The unique heterostructure with abundant active sites, large specific surface area, and core-shell design not only boosts ion/electron migration but also inhibits volume change and vanadium dissolution during the repeated Zn 2+ ion insertion/extraction processes, enabling enhanced Zn 2+ ion storage performance and structural stability. As expected, the VO-CeVO cathode delivers a high capacity of 346.3 mAh g −1 at 0.5 A g −1 , excellent rate capability (257.0 mAh g −1 at 10 A g −1 ), and outstanding cycling performance (over 10 000 cycles).}, archive = {J_ADVS}, author = {Dan Liu and Yinxiang Zeng and Yue Xu and Qiang Liu and Deyan Luan and Yan Guo and Xiaojun Gu}, doi = {10.1002/advs.202505993}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05993}, shortjournal = {Adv. Sci.}, title = {Design and synthesis of core-shell nanospheres composed of heterostructured V2O5-CeVO4 toward efficient zn-ion storage}, volume = {12}, year = {2025}, }
• (2025). Controlling energy flow in perovskite heterostructures through dimensionality and phase engineering. ADVS, 12(34), e05971. (www)

  @article{ , abstract = {Metal halide perovskites have emerged as a transformative class of semiconductors, driving advancements in optoelectronics, photovoltaics, and sensing technologies. One of the key challenges in optimizing these materials for next-generation devices is controlling the flow of energy within them, which is highly sensitive to structural and dimensional factors. Recent advances in phase and dimensionality engineering have opened new avenues for tailoring energy transport and excitonic behaviors in perovskite heterostructures. By controlling the dimensionality and tuning the phases of perovskites, it is possible to achieve enhanced efficiency, stability, and selectivity in energy transfer processes. This perspective explores the fundamental principles of energy flow in perovskites and related materials, highlighting how phase transitions and dimensionality control can be leveraged to design optimized heterostructures for cutting-edge optoelectronic applications.}, archive = {J_ADVS}, author = {Danila A. Tatarinov and Alexander Schleusener and Roman Krahne}, doi = {10.1002/advs.202505971}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05971}, shortjournal = {Adv. Sci.}, title = {Controlling energy flow in perovskite heterostructures through dimensionality and phase engineering}, volume = {12}, year = {2025}, }
• (2025). Color-tunable glass for adaptable thermal management based on silver phase change. ADVS, 12(34), e05791. (www)

  @article{ , abstract = {In recent years, passive thermal management systems have emerged as an essential energy-saving strategy to mitigate carbon emissions. However, traditional heat management approaches, such as photothermal devices and radiative coolers, often face application limitations due to their complex construction, aesthetic constraints, and inability to adapt to diverse architectural requirements. This study proposes a colored thermal engineering glass fabricated through a simple annealing process, where Ag nanoparticles are formed on a TiO 2 film and an Ag layer. The structure of Ag layers can be easily controlled by adjusting the annealing temperature, allowing for systematic tuning of the optical efficiencies in the visible and long-wave infrared regions. Consequently, thermal management devices can selectively function as either a photothermal heater or a radiative cooler, depending on the morphology of Ag layers. In particular, the photothermal device can function as an anti-fogging solution for structural designs without requiring external energy. Furthermore, the stacked metal-insulator-metal structure induces plasmonic resonance phenomena, producing visible colors that range from vivid to dull hues. The tunable color variations enhance the suitability of the thermal management device for a wide range of architectural applications.}, archive = {J_ADVS}, author = {Mi Jin Hong and Seon Kyeong Kim and Jung Mi Im and Ik Hoon Jeong and Min Ju Kim and Jeong Jin Kim and Yeong Jae Kim and Gil Ju Lee}, doi = {10.1002/advs.202505791}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05791}, shortjournal = {Adv. Sci.}, title = {Color-tunable glass for adaptable thermal management based on silver phase change}, volume = {12}, year = {2025}, }
• (2025). A general strategy for bandgap engineering via anion-lattice doping in high-entropy oxides. ADVS, 12(34), e05789. (www)

  @article{ , abstract = {Bandgap engineering is a critical tool for tailoring the electronic properties of functional materials, traditionally achieved by modifying the cation sublattice. Here, a generalizable strategy is introduced that leverages facile anion-lattice doping in high entropy materials to modulate the bandgap in high-entropy metal oxides (HEMOs). By incorporating nitrogen into a single-phase high-entropy metal oxide/nitride (HEMO:HEMN) solid solution, a substantial bandgap reduction is achieved from 3.55 eV (HEMO) to ≈2.46 eV (HEMO:HEMN), significantly enhancing electronic conductivity. Unlike conventional bandgap tuning approaches that rely on cation substitution or heterojunction formation, this method exploits anion-mediated entropy stabilization, enabling uniform bandgap narrowing across the entire solid solution. This anion-lattice engineering strategy is broadly applicable to high-entropy systems, providing a new pathway for designing energy materials with tailored electronic properties. The resulting HEMO:HEMN solid solution exhibits a tenfold increase in capacitance and capacity compared to HEMO in supercapacitor and lithium-ion battery tests, demonstrating the transformative potential of anion-driven bandgap modulation for next-generation energy storage and conversion technologies.}, archive = {J_ADVS}, author = {Kevin Siniard and Juntian Fan and Meijia Li and Qingju Wang and Alexander S. Ivanov and Tao Wang and Sheng Dai}, doi = {10.1002/advs.202505789}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05789}, shortjournal = {Adv. Sci.}, title = {A general strategy for bandgap engineering via anion-lattice doping in high-entropy oxides}, volume = {12}, year = {2025}, }
• (2025). Coordination geometry tuning in a single-atom nanozyme to mimic metalloenzymes with nonplanar active site. ADVS, 12(34), e05733. (www)

  @article{ , abstract = {Single-atom nanozymes (SAzymes) have been developed to mimic metalloenzymes by modulating their coordination environment. However, the impact of the coordination geometry at the metal center on the catalytic activity of the SAzymes, particularly those with nonplanar active site configurations, has been minimally explored. Here, the effects of the geometric configuration of the Zn–N 4 active sites on the catalytic activity of the carbonic anhydrase (CA)-mimetic SAzymes are reported. CA-mimetic SAzymes with Zn–N 4 active sites in tetrahedral, distorted tetrahedral, and square-planar configurations are prepared by simple temperature-controlled carbonization of ZIF-8. The SAzyme with the distorted tetrahedral Zn–N 4 configuration displays superior catalytic CO 2 hydration activity, attributed to increased Lewis acidity. Density functional theory (DFT) calculations reveal a pronounced Zn–OH affinity and localized electron accumulation at the distorted tetrahedral Zn site. These results demonstrate the critical role of precise geometric tuning in enhancing SAzyme efficacy and can be used to facilitate potential avenues for optimizing metal active centers in enzyme mimetics.}, archive = {J_ADVS}, author = {Hyesung Lee and Changjoon Keum and Choah Kwon and Sangtae Kim and Youngdo Jeong and Sang-Yup Lee}, doi = {10.1002/advs.202505733}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05733}, shortjournal = {Adv. Sci.}, title = {Coordination geometry tuning in a single-atom nanozyme to mimic metalloenzymes with nonplanar active site}, volume = {12}, year = {2025}, }
• (2025). Magnetic field-driven catalysis: Revealing enhanced oxygen reactions in li-o2 batteries using tailored magnetic nanocatalysts. ADVS, 12(34), e05633. (www)

  @article{ , abstract = {Lithium-oxygen (Li-O 2 ) batteries offer immense promise for next-generation energy storage technology due to their ultra-high theoretical energy density. However, their adoption faces challenges like large overpotential and slow oxygen reaction kinetics. This study introduces a novel strategy that leverages custom-designed magnetic nanocatalysts and external magnetic fields to boost electrochemical performance. Mn-Co-Fe oxide catalysts with adjustable magnetic properties is developed and demonstrated the correlation between the magnetism of the catalysts and the enhancement of battery performance. In the presence of an external magnetic field, the paramagnetic oxygen molecules experience a Kelvin force, while the Li + ions are influenced by a Lorentz force. This accelerates their diffusion, significantly enhancing the kinetics of both the oxygen reduction and oxygen evolution reactions. The catalyst with the highest magnetization boosted specific capacity by 52.9% (from 8143 to 12 455 mAh g⁻¹) and significantly lowered the overpotential. This breakthrough underscores magnetic field-driven catalysis as a crucial advancement in unlocking the full potential of Li-O 2 batteries, setting new benchmarks for energy storage technology.}, archive = {J_ADVS}, author = {Yimin Chen and Xin Hu and Min Hong and Yi Zhu and Yuyu Su and Ye Fan and Zhenxiang Cheng and John Bell and Baozhi Yu and Ying Ian Chen}, doi = {10.1002/advs.202505633}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05633}, shortjournal = {Adv. Sci.}, title = {Magnetic field-driven catalysis: Revealing enhanced oxygen reactions in li-o2 batteries using tailored magnetic nanocatalysts}, volume = {12}, year = {2025}, }
• (2025). Developing biomaterial-based mRNA delivery system for lung disease treatment. ADVS, 12(34), e05413. (www)

  @article{ , abstract = {Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery. Various biomaterials—including nanoparticles such as liposomes, polymers, hybrid systems, dendritic polymers, gold nanoparticles, mesoporous silica, calcium carbonate, and exosomes—exhibit excellent biocompatibility. These materials protect therapeutic agents from nuclease degradation, stabilize drug carriers, and enhance cellular uptake via mechanisms such as endocytosis. Chemical modifications further improve biomaterials by facilitating endosomal escape and conjugation with targeting ligands, thereby enabling precise delivery to specific cells or tissues. As a therapeutic modality, mRNA offers high biosafety, notable controllability, efficient translation, and immunomodulatory properties. This review evaluates the impact of lung structure on drug absorption, examines delivery mechanisms associated with various biomaterial types, and presents application examples. It also summarizes recent research developments, discusses clinical limitations, and explores future research directions for biomaterials in lung disease therapy. Additionally, it highlights the role of biomaterials in stabilizing and protecting mRNA, providing insights into the advancement of mRNA-based therapeutics. This review aims to establish a robust theoretical foundation and offer practical guidance for biomaterial-based mRNA therapies in treating lung diseases.}, archive = {J_ADVS}, author = {Qiancheng Gu and Huaqian Xue and Zhiyun Liu and Jiameng Rao and Lingyao Zeng and Chen Zhang and Lanjie Lei and Liyun Shi}, doi = {10.1002/advs.202505413}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05413}, shortjournal = {Adv. Sci.}, title = {Developing biomaterial-based mRNA delivery system for lung disease treatment}, volume = {12}, year = {2025}, }
• (2025). Inhalable artificial polymeric nucleases degrading neutrophil extracellular trap-DNAs and alleviating pulmonary fibrosis. ADVS, 12(34), e05357. (www)

  @article{ , abstract = {Pulmonary fibrosis resulting from recurrent lung inflammation due to pathogen infection may lead to serious problems and death. Neutrophil extracellular traps (NETs), consisting of DNAs and proteins released by neutrophils in response to infection, are major pathogenesis factors for pathogen-associated pulmonary fibrosis. By mimicking nucleic acid hydrolase, polymeric artificial DNases bearing imidazole units (PEG-PIm) are developed to degrade the DNAs and thus deconstruct NETs, inhibiting pulmonary fibrosis. By tailoring the PIm segments with varied imidazole units, the polymer hydrolase with a defined number of imidazole units outperforms other samples in the cleavage of DNAs and inhibits the transition of pulmonary fibroblasts to myofibroblasts. This polymer digests the DNAs complexed with cationic peptides, unlike natural DNase I. By aerosol inhalation, it reduces NET infiltration in lungs and significantly alleviates inflammatory cytokines and fibrosis. Molecular dynamics simulations indicate that the optimized polymer may expose more effective imidazole units to the DNA backbones and thus enhance the affinity and hydrolysis of phosphodiester linkages. The function is also confirmed by systematic administration of PEG-PIm to rheumatoid arthritis. Thus, a strategy is provided for treating pulmonary fibrosis that can be applied in a pandemic to reduce high mortality because of pathogen infection.}, archive = {J_ADVS}, author = {Yibo Du and Chenxu Zhu and Ruifeng Wang and Shi Chen and Chuang Li and Defang OuYang and Lixin Liu and Yongming Chen}, doi = {10.1002/advs.202505357}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05357}, shortjournal = {Adv. Sci.}, title = {Inhalable artificial polymeric nucleases degrading neutrophil extracellular trap-DNAs and alleviating pulmonary fibrosis}, volume = {12}, year = {2025}, }
• (2025). Biomimetic analysis of neurotransmitters for disease diagnosis through light-driven nanozyme sensor array and machine learning. ADVS, 12(34), e05333. (www)

  @article{ , abstract = {Neurological diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, pose a significant global health challenge due to their complex pathogenesis and widespread prevalence. These disorders are often associated with disruptions in neurotransmitter regulation, leading to progressive cognitive and motor impairments. Conventional diagnostic methods are time-consuming and lack the sensitivity required for early-stage detection. Herein, for the first time a novel photoresponsive nanozyme sensor array is presented that integrates metal-organic frameworks (MOFs) and machine learning algorithms for the rapid, sensitive, and multiplexed detection of neurotransmitters. Wherein, Zn(II) meso-Tetra(4-carboxyphenyl)porphine (ZnTCPP) -based MOFs, with their large specific surface area, enhance the interaction between reactant substrates and catalytic active sites within the material, significantly improving response sensitivity. Additionally, light-driven catalysis greatly accelerates the response speed of the nanozyme. Mimicking the mammalian olfactory system, the array responds to various neurotransmitters in a patterned manner, enabling accurate differentiation and quantification within minutes. It maintains high precision even in complex biological samples such as serum and cerebrospinal fluid. The biomimetic sensor can detect neurotransmitter signatures linked to neurological disorders, such as Alzheimer's disease. This platform offers significant potential for early diagnosis and continuous monitoring of neurological conditions.}, archive = {J_ADVS}, author = {Kun Yu and Siyuan Lu and Kaiwen Qiu and Yuanzun Zhang and Aobing Sun and Shiqi Gong and Kai Wang and Xuzhu Gao and Xiangyu Xu and Hao Wang}, doi = {10.1002/advs.202505333}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05333}, shortjournal = {Adv. Sci.}, title = {Biomimetic analysis of neurotransmitters for disease diagnosis through light-driven nanozyme sensor array and machine learning}, volume = {12}, year = {2025}, }
• (2025). Bidirectional phase separation spinning under natural drying to prepare aerogel fibers for thermal insulation. ADVS, 12(34), e05306. (www)

  @article{ , abstract = {Aerogel fibers have emerged as a promising solution in thermal insulation. Yet, the current preparation methods pose challenges: they are either inefficient for continuous production or involve energy-intensive and time-consuming steps like freeze-drying or supercritical drying, thus restricting their practical utility. Here, a bidirectional phase separation spinning technique is introduced for continuous and rapid production (360 m h −1 ) of aerogel fibers at any desired length. Importantly, fibers can be directly dried at room temperature, eliminating the need for energy-intensive freeze-drying or other additional steps, significantly reducing energy consumption and processing time. Aerogel fibers produced using this method exhibit remarkable properties: low density (0.18 g cm − 3 ), high porosity (84%), and broad operational temperature range (−20 to 120 °C). Notably, the thermal insulation mat composed of these aerogel fibers achieves an exceptionally low thermal conductivity (31 ± 1.2 mW/(mK)). This work provides a novel strategy for the preparation of aerogel fibers, achieving energy savings and efficiency, positioning aerogel fibers as a promising alternative for next-generation textiles.}, archive = {J_ADVS}, author = {Jiaxin Shen and Shisheng Hou and Chen Li and Kuibo Yin and Li Zhong and Hengchang Bi and Litao Sun}, doi = {10.1002/advs.202505306}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05306}, shortjournal = {Adv. Sci.}, title = {Bidirectional phase separation spinning under natural drying to prepare aerogel fibers for thermal insulation}, volume = {12}, year = {2025}, }
• (2025). Optimized synthesis and characterization of janus RhSeCl with uniform anionic valences, nonlinear optical and optoelectronic properties. ADVS, 12(34), e05279. (www)

  @article{ , abstract = {The symmetry-breaking nature of Janus materials enables the design of multifunctional compounds with distinct properties that are inaccessible to traditional materials. However, the limited availability of intrinsically stable Janus materials hinders a complete understanding of their full potential. Here, the first millimeter-sized Janus material, RhSeCl, is successfully synthesized through the precisely controlled chemical vapor transport (CVT) method. Single-crystal X-ray diffraction and high-resolution transmission electron microscopy analyses reveal the Janus character of RhSeCl, emphasizing its strong correlation with steric hindrance. X-ray absorption near-edge structure (XANES) analyses demonstrate the highly unusual oxidation states of Rh and Se, underlining their critical role in determining the formation of the inherent Janus structure. Interestingly, a clear second-harmonic generation (SHG) is observed in RhSeCl, weakening with the temperature. DFT calculations attribut the strong SHG response to the band nesting effect, with an intensity modulated by the temperature-dependent interlayer coupling. Notably, its damage threshold surpassed that of Janus MoSSe. Furthermore, devices based on RhSeCl exhibit promising optoelectronic performance at the visible wavelength range of 405–650 nm, showing a great opportunity for solar applications. These findings deepen the understanding of inherent Janus structures, paving the way for the development of new Janus compounds with versatile functionalities in advanced materials.}, archive = {J_ADVS}, author = {Kefeng Liu and Xuelian Sun and Puxin Cheng and Zhiteng Li and Penghui Li and Donghan Jia and Shijing Zhao and Xin Yang and Xinyu Wang and Liangting Ye and Shengqing Xia and Shuo Zhang and Yu Chen and Tao Gan and Jiong Li and Xiao Zhang and Jialiang Xu and Anmin Nie and Bing Huang and Huiyang Gou}, doi = {10.1002/advs.202505279}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05279}, shortjournal = {Adv. Sci.}, title = {Optimized synthesis and characterization of janus RhSeCl with uniform anionic valences, nonlinear optical and optoelectronic properties}, volume = {12}, year = {2025}, }
• (2025). Upper limb motor function rehabilitation system leveraging pressure-sensitive intent recognition. ADVS, 12(34), e05259. (www)

  @article{ , abstract = {Functional electrical stimulation (FES) enhances daily living and rehabilitation outcomes for stroke patients but faces challenges in intention recognition, individual adaptability, and closed-loop control. To address these, a reconstruction system is presented for upper limb motor function, employing highly pressure-sensitive liquid metal magnetorheological elastomers (LMMRE） to detect muscle surface pressure. It can dynamically modulate functional electrical stimulation based on muscle force signals, enabling continuous execution of wrist movements for stroke patients. The system markedly improves patient mobility, with wrist lifting angles increased from 14° to 47°, and lifting speed nearly doubled. Clinical trials confirm the system's superior efficacy in promoting motor recovery and reducing muscle spasms. Moreover, functional near-infrared spectroscopy highlights enhanced brain activity and promotes reconstruction of damaged neural pathways during LMMRE-FES therapy compared with the conventional electrical stimulation. This system holds immense potential for advancing stroke rehabilitation, paving the way for portable, wearable devices optimized for home-based care.}, archive = {J_ADVS}, author = {Zhiwei Hu and Yongchao Yin and Xiaoli Yang and Hanyang Zhang and Ling Xing and Shiwu Zhang and Xinglong Gong and Ming Wu and Guolin Yun and Shuaishuai Sun}, doi = {10.1002/advs.202505259}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05259}, shortjournal = {Adv. Sci.}, title = {Upper limb motor function rehabilitation system leveraging pressure-sensitive intent recognition}, volume = {12}, year = {2025}, }
• (2025). An amygdala-hippocampus circuit for endocannabinoid modulation of anxiety avoidance. ADVS, 12(34), e05121. (www)

  @article{ , abstract = {Recent studies indicate a therapeutic potential of increased brain endocannabinoids (eCBs) in anxiety disorders, but the underlying brain circuits are still elusive. Here, it is observed that optogenetic inhibition and activation of anterior basolateral amygdala (aBLA) - ventral hippocampus (vHPC) glutamatergic projections respectively decrease and increase anxiety avoidance behaviors. Then, the contributions of eCBs in aBLA–vHPC projections to anxiety avoidance are investigated by employing three newly developed synapse- and circuit-specific eCB-targeted viral strategies to achieve real-time monitoring of eCB release, in vivo optogenetic activation of CB1 receptors, and CRISPR-Cas9 gene knockdown of eCB biosynthesis enzymes. Prominent eCB release are surprisingly found at aBLA–vHPC glutamatergic synapses during anxiety avoidance, suggesting inhibitory effects of increased eCBs in aBLA–vHPC projections on anxiety avoidance. This idea is further supported by findings that specific activation of CB1 receptors at aBLA–vHPC synapses inhibit presynaptic glutamate release and reduce anxiety avoidance. In contrast, specific knockdown of eCB biosynthesis enzymes at aBLA–vHPC synapses reduce eCB levels at aBLA–vHPC glutamatergic synapses and increase anxiety avoidance. Additionally, inhibition of aBLA-innervated vHPC glutamatergic neurons alleviates anxiety avoidance. Together, these findings reveal counteracting effects of increased eCB signaling in aBLA–vHPC circuits on anxiety avoidance.}, archive = {J_ADVS}, author = {Bao Xue and Mao-Xing Zhang and Xiao-Chen Bi and Shou-Peng Lai and Xin-Tian Bie and Yuan Dong and Jian-Feng Li and Fang Gao and Xia Zhang and Ying Wang}, doi = {10.1002/advs.202505121}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05121}, shortjournal = {Adv. Sci.}, title = {An amygdala-hippocampus circuit for endocannabinoid modulation of anxiety avoidance}, volume = {12}, year = {2025}, }
• (2025). Lysosome-featured cell aggregate-released extracellular vesicles regulate iron homeostasis and alleviate post-irradiation endothelial ferroptosis for mandibular regeneration. ADVS, 12(34), e05070. (www)

  @article{ , abstract = {Ferroptosis, a form of regulated cell death driven by iron accumulation and lipid peroxidation, is implicated in various diseases, but effective therapeutic strategies remain limited. Lysosomal impairments cause iron dysregulation and initiate ferroptosis, which potentially contribute to ionizing radiation-induced tissue damages. Here, the role of intercellular lysosomal regulation in governing iron homeostasis and protecting against ferroptosis is investigated in models of stem cell aggregation and mandibular regeneration post-irradiation. Lysosomes are discovered to accumulate in specific regions within multi-stem cell aggregates and regulate cell aggregate formation based on iron control, which is occurred through hypoxic signaling-driven lysosomal redistribution mediated by extracellular vesicles. These vesicles exhibit lysosomal features and possess iron-regulating properties, which rescue lysosomal defects to restore iron homeostasis and mitigate ferroptosis in recipient endothelial cells against the irradiation challenge. Based on lysosomal regulation and anti-ferroptosis, these cell aggregate-released extracellular vesicles (CA-EVs) stimulate the growth of CD31 + endomucin + specialized vessels despite irradiation both in vitro and in vivo, which further promote bone regeneration of post-irradiation mandibular defect. These findings highlight the potential of taking CA-EVs as natural therapeutic agents to safeguard lysosomal function, modulate iron metabolism, and protect against ferroptosis, paving an avenue for combating post-irradiation endothelial injuries and enhancing tissue regeneration.}, archive = {J_ADVS}, author = {Yuan-Yuan Li and Bo Ma and Jia-Wei Lu and Kai-Chao Zhang and Chao Ma and Sheng-Feng Bai and Yan-Jiao Li and Si-Qi Ying and Wei-Zong Weng and Kai Zhang and Xi-Wang Hu and Rang Li and Chen-Xi Zheng and Xiao-Ru Xu and Ji Chen and Fang Jin and Hao-Kun Xu and Jian-Wei Xie and Yan Jin and Yi Shuai and Bing-Dong Sui}, doi = {10.1002/advs.202505070}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05070}, shortjournal = {Adv. Sci.}, title = {Lysosome-featured cell aggregate-released extracellular vesicles regulate iron homeostasis and alleviate post-irradiation endothelial ferroptosis for mandibular regeneration}, volume = {12}, year = {2025}, }
• (2025). Controllable preparation of millimeter-scale in-plane charged domain wall in a lead-free ferroelectric film. ADVS, 12(34), e05069. (www)

  @article{ , abstract = {Ferroelectric domain walls are emerging as active components in nanoelectronics, offering a transformative paradigm for non-volatile memory and logic technologies. In particular, in-plane charged domain walls stand out for their potential to support unique functionalities, such as quantum confinement and tunneling effects, unlocking new possibilities for advanced device applications. Here, a facile approach is developed for fabricating large-scale continuous in-plane charged domain walls in Na 0.5 Bi 0.5 TiO 3 ferroelectric films through thermally optimized growth control. Using Differential Phase Contrast Scanning Transmission Electron Microscopy, an electric field fluctuation is identified across the charged domain wall. This fluctuation is accompanied by oxygen octahedron distortions, which allow the lattice to redistribute charges, as confirmed by integrated Differential Phase Contrast analyses. Additionally, Electron Energy Loss Spectroscopy reveals variations in titanium oxidation states across the domain wall, which compensates for the charge accumulation and enhances the stability of the charged domain wall. This work presents a wafer-scale fabrication strategy for in-plane charged domain walls and provides atomic-scale insights into their stabilization mechanisms, offering a foundation for their integration into domain-wall-based nanodevices and on-chip applications.}, archive = {J_ADVS}, author = {Fang Liu and Mei-Xiong Zhu and Jia-Qi Liu and Li-Xin Yang and Yu-Jia Wang and Yin-Lian Zhu and Xiu-Liang Ma and Yun-Long Tang}, doi = {10.1002/advs.202505069}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05069}, shortjournal = {Adv. Sci.}, title = {Controllable preparation of millimeter-scale in-plane charged domain wall in a lead-free ferroelectric film}, volume = {12}, year = {2025}, }
• (2025). A multifunctional photothermal catalyst enabling full-day sustainable power and indoor air quality control. ADVS, 12(34), e05059. (www)

  @article{ , abstract = {Solar photothermal catalytic (PTC) purification holds great potential for indoor air pollution control, but efficiently collecting energy at the catalytic interface to maximize solar energy utilization and meet building requirements remains a global challenge. This study develops a novel infrared-light-driven photothermal catalyst, Mn 7 Co 3 Ce 1 O x , which efficiently utilizes solar and ambient energy, offering three functions: catalysis, heating, and cooling. Furthermore, this study proposes an innovative hybrid system that integrates PTC film, thermoelectric generator (TEG), and metal–organic frameworks (MOFs). Through synergetic effects, the system combines the heating-catalysis-cooling effect of the PTC film with the moisture-induced adsorption/desorption heat of the MOFs, achieving year-round power generation, dehumidification, and air purification. Results show that Mn 7 Co 3 Ce 1 O x has a full-spectrum solar absorptivity of 94.3% and an atmospheric window emissivity of 95.7%. Under infrared light, the pollutant removal rate on the photothermal catalytic interface reaches 90.9%. Within 4 h, the thermoelectric power density increased by 640.1%, the relative humidity decreased by 16.8%, and the clean air volume reached 270.8 m 3 ·h −1 ·m −2 . When the system is applied to building rooftops in 34 provincial capital cities in China, the simulation results show annual power density of 30–105.3 kW·m⁻ 2 , air conditioning energy savings of 11.2–353.5 kW·m −2 , and clean air volume of 296.3–1119.3 m 3 ·h −1 ·m −2 .}, archive = {J_ADVS}, author = {Niansi Li and Wei Wei and Yulin Li and Feiyang Xu and Guoyu Zhang and Jie Ji and Xudong Zhao and Junwei Liu and Bendong Yu and Qiliang Wang}, doi = {10.1002/advs.202505059}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e05059}, shortjournal = {Adv. Sci.}, title = {A multifunctional photothermal catalyst enabling full-day sustainable power and indoor air quality control}, volume = {12}, year = {2025}, }
• (2025). Detection of metal impurity particles in lead-acid battery electrolyte based on lens-free digital holography technology. ADVS, 12(34), e04991. (www)

  @article{ , abstract = {Lead-acid batteries, widely used in energy storage and power systems, are susceptible to performance degradation due to metal impurities such as iron, copper, and tin. Traditional methods like ICP-OES are accurate but costly and complex. Therefore, this study proposes a new method based on lens-free digital holography (LDH) to detect and distinguish metal impurities in lead-acid battery electrolytes. The study uses a compact setup with a green LED light source and a CMOS camera to capture holographic images of impurities. The technique reconstructs clear particle images using angular spectrum algorithms and analyzes their reconstruction distances and gray-scale differences for identification. Results show that copper particles have a reconstruction distance of 1406.4 µm and a total gray-scale difference of 4.4681; tin particles have a reconstruction distance of 1414.85 µm and a total gray-scale difference of 0.5344; iron hydroxide has a reconstruction distance of 1647.85 µm and the total gray-scale difference of 13.5789. By combining these parameters, the method effectively distinguishes between copper, tin, and iron particles, even in mixed solutions. This cost-effective and efficient method offers a promising alternative for rapid and accurate detection of metal impurities in lead-acid battery electrolytes, with potential applications in battery maintenance and quality control.}, archive = {J_ADVS}, author = {Liang Xue and Hao Zhou and Hao Chen and Zhihao Jiang and Chao Jiang and Haoyang Cui}, doi = {10.1002/advs.202504991}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04991}, shortjournal = {Adv. Sci.}, title = {Detection of metal impurity particles in lead-acid battery electrolyte based on lens-free digital holography technology}, volume = {12}, year = {2025}, }
• (2025). KRAS mRNA spleen-targeting lipid nanoparticles synergize with irinotecan silicasomes to robustly augment the cancer immunity cycle in pancreatic cancer. ADVS, 12(34), e04886. (www)

  @article{ , abstract = {Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies due to its immunosuppressive tumor microenvironment. It is hypothesized that overcoming these barriers requires a dual approach: inducing immunogenic tumor cell death (ICD) and enhancing the cancer immunity cycle by exogenous neoantigen targeting on the spleen. In this study, a novel strategy is presented combining irinotecan-loaded silicasomes with spleen-targeting lipid nanoparticles (LNPs) carrying KRAS G12D mRNA and the toll-like receptor 7/8 (TLR7/8) agonist 3M-052. The goal is to establish a cancer immunity cycle by promoting endogenous tumor antigen release by the generation of KRAS-specific cytotoxic T cells. Using an orthotopic PDAC mouse model, it is demonstrated that this dual-platform approach significantly reduces tumor burden and extends survival compared to monotherapies. Bulk RNA sequencing and gene expression analyses further reveal synergy between the immune responses at the primary tumor site and the spleen, including maximal upregulation of apoptosis-related genes, endoplasmic reticulum stress pathways, antigen presentation pathways, and T cell activation markers. These findings indicate that the combinatorial strategy effectively bridges innate and adaptive immunity. In conclusion, this study highlights the potential of nanocarrier-based immunotherapy to enhance PDAC immunity by integrating ICD induction with systemic immune reprogramming, offering a promising avenue for improving treatment outcomes.}, archive = {J_ADVS}, author = {Lijia Luo and Xiang Wang and Yu-Pei Liao and Andre E. Nel}, doi = {10.1002/advs.202504886}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04886}, shortjournal = {Adv. Sci.}, title = {KRAS mRNA spleen-targeting lipid nanoparticles synergize with irinotecan silicasomes to robustly augment the cancer immunity cycle in pancreatic cancer}, volume = {12}, year = {2025}, }
• (2025). Lysosomal cathepsin s escape facilitates near infrared light-triggered pyroptosis via an antibody-indocyanine green conjugate. ADVS, 12(34), e04851. (www)

  @article{ , abstract = {Pyroptosis is a proinflammatory programmed cell death (PCD) that is causally linked to antitumor immune responses, but the therapeutic potential of pyroptosis has been limited by the lack of tumor-specific and controllable inducers. Here, it is reported that tumor-specific pyroptosis can be spatiotemporally triggered via near-infrared light (NIR-pyroptosis) by using an antibody-bound indocyanine green (ICG), a clinically approved and nontoxic fluorescent dye. Mechanistically, the key molecular steps are identified by which antibody-bound ICG generates excessive reactive oxygen species (ROS) within lysosomes after internalization, leading to lysosomal membrane damage and the cytosolic release of cathepsin S (CTSS), which cleaves gasdermin D (GSDMD), IL-18, and IL-1β independently of caspase-1, and thereby induces pyroptosis, while other cathepsin family members fail to cleave GSDMD. Functionally, in both ICAM1+ and HER2+ solid tumors, antibody-bound ICG-mediated NIR-pyroptosis triggers potent and durable antitumor immune responses through the release of proinflammatory cytokines. Furthermore, NIR-pyroptosis synergize with anti-PD-1 therapy by activating adaptive immune cells via upregulated IFN-γ secretion. The findings identify CTSS as a novel enzyme for GSDMD cleavage and establish NIR-pyroptosis as a non-apoptotic anticancer modality, providing a promising opportunity to overcome apoptosis resistance in current cancer therapies.}, archive = {J_ADVS}, author = {Fan Chen and Xue-Fei Tian and Teng Yang and Yu-Jie Dai and Da-Yuan Chen and Hong-Bo Chen and Takaya Shimura and Xin-Fang Li and Chu-Lin Sha and Qing Ji and Jun Cao and Mei-Yu Fang and Jin-Biao Shang and Jian-Min Fang and Ye Lu and Wei-Hui Zheng and Peng Guo and Wei-Hong Tan}, doi = {10.1002/advs.202504851}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04851}, shortjournal = {Adv. Sci.}, title = {Lysosomal cathepsin s escape facilitates near infrared light-triggered pyroptosis via an antibody-indocyanine green conjugate}, volume = {12}, year = {2025}, }
• (2025). Polymer-driven co-assembly of achiral and chiral nanoparticles into plasmonic nanoclusters with quantitatively modulated optical chirality. ADVS, 12(34), e04850. (www)

  @article{ , abstract = {Chiral plasmonic nanoassemblies demonstrate enhanced chiral optical activity through plasmonic mode coupling, holding transformative potential for applications in sensing, catalysis, and quantum-optical technologies. However, the mechanisms underlying this enhancement—particularly the roles of structural geometry, plasmonic coupling, and chiral field amplification—remain incompletely elucidated. A significant challenge persists in designing coupled nanoassemblies with precisely controlled nanostructures to systematically investigate chirality enhancement. Departing from conventional approaches that incorporate chiral molecules, we present the co-assembly of achiral and chiral plasmonic nanoparticles (NPs) into AB n -type nanoclustersand the correlation between inherent plasmonic chirality and the quantity of hotspots. Complementary polymer-grafted achiral nanospheres and chiral nano arrows assemble into stable AB n clusters through a combination of electrostatic interactions and hydrogen bonding. The coordination number ( n ) of AB n can be tuned from 2 to 7 by adjusting polymer configurations through modulation of solution pH. The g -factor of AB n exhibits a linear increase with the n value of AB n . Simulation results indicate that the enhanced optical chirality arises from the increase in electric field strength due to the increasing number of hotspots within the NP assemblies.}, archive = {J_ADVS}, author = {Chongyang Yao and Huibin He and Weijia Kong and Liangyu Hu and Xiaoxue Shen and Jing Tao and Yutao Sang and Zhihong Nie}, doi = {10.1002/advs.202504850}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04850}, shortjournal = {Adv. Sci.}, title = {Polymer-driven co-assembly of achiral and chiral nanoparticles into plasmonic nanoclusters with quantitatively modulated optical chirality}, volume = {12}, year = {2025}, }
• (2025). Low temperature fast-charging li ion batteries enabled by f-orbital hybridization induced TiNb2O7 electronic structure. ADVS, 12(34), e04808. (www)

  @article{ , abstract = {Li-ion batteries for electric vehicles and aviation require fast charging, long cycle life, and a wide operating temperature range. However, the lack of anode materials that offer both high capacity and stability at high charging/discharging rates significantly impedes their development. Herein, the introduction of lanthanide with f-Orbital electronic configurations widens the ion transport channels and significantly alters the original electronic structure, leading to a notable improvement in acceleration kinetics. X-ray absorption spectroscopy is employed to depict lanthanide earth elements that can lower lattice strain and accelerate the diffusion of Li + . The Tm 0.01 -TNO delivers an outstanding specific capacity of 150.9 mAh g −1 at 50 C. Even at low temperatures (−30 °C), Tm 0.01 -TNO exhibits stable cycling performance with 100% capacity retention over 500 cycles at 1 C. This work demonstrates an enormous promise for scalability in practical low-temperature applications.}, archive = {J_ADVS}, author = {Anran Shi and Lichao Tan and Xiumei Song and Shenglu Geng and Wenting Li and Jiayi Wang and Kai Zong and Lin Yang and Dan Luo and Shuaifeng Lou and Xin Wang and Biqiong Wang and Zhongwei Chen}, doi = {10.1002/advs.202504808}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04808}, shortjournal = {Adv. Sci.}, title = {Low temperature fast-charging li ion batteries enabled by f-orbital hybridization induced TiNb2O7 electronic structure}, volume = {12}, year = {2025}, }
• (2025). Bio-inspired structural color irises as physical unclonable functions for anti-counterfeiting. ADVS, 12(34), e04771. (www)

  @article{ , abstract = {The global proliferation of high-value commodities has the intensified demand for advanced anti-counterfeiting solutions. Physical Unclonable Functions (PUFs) present a viable authentication mechanism, yet existing implementations exhibit three critical limitations: suboptimal authentication accuracy, insufficient multi-level security architecture, and dependence on costly and specialized equipment for verification. To address these issues, this work utilizes colloidal photonic crystals to fabricate PUF anti-counterfeiting patterns spanning from the macro-to-micro scale. These patterns are integrated with the iris recognition algorithm to construct a multi-layered optical anti-counterfeiting system based on the structural color iris. This work experimentally and computationally demonstrates that the “Ring”-type colloidal photonic crystals originate from the “coffee ring” effect. By modulating the “coffee ring” effect, the size of the colloidal photonic crystal iris patterns can be controlled, enabling switching between “Ring”-type and “Dot”-type colloidal photonic crystals. Furthermore, multiple characteristic parameters confirm that the PUF codes derived from encoded “Ring”-type colloidal photonic crystal images exhibit uniqueness and readability. Finally, a multi-layered anti-counterfeiting system is constructed, comprising three components: structural color patterns, embedded “Morse codes” formed by “Ring”-type and “Dot”-type colloidal photonic crystals, and optical PUF labels based on the “Ring”-type colloidal photonic crystals. This cost-effective system enables low-threshold, high-performance structural color anti-counterfeiting for premium products.}, archive = {J_ADVS}, author = {Kongyu Ge and Yiming Hu and Jiangnan Yan and Jianing Ding and Yifan Gao and Hongyu Yi and Zhan Li and Lingfei Cui and Shaowei Hu and Hongjun Ji and Mingyu Li and Ruobing Bai and Rongpei Shi and Huanhuan Feng}, doi = {10.1002/advs.202504771}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04771}, shortjournal = {Adv. Sci.}, title = {Bio-inspired structural color irises as physical unclonable functions for anti-counterfeiting}, volume = {12}, year = {2025}, }
• (2025). Artificial room-temperature ferromagnetism of bulk van der waals VSe2. ADVS, 12(34), e04746. (www)

  @article{ , abstract = {Originating from spin and orbital motion, van der Waals (vdW) ferromagnetism has emerged as a significant platform to experimentally access the fundamental physics of magnetism in reduced dimensions, including quantum computing, sensing, and data storage. However, currently, available vdW ferromagnetic materials can be achieved with mechanical exfoliation and low-temperature operation, which completely limits the monolithic integration of vdW ferromagnets with other functional materials. Nonetheless, the direct synthesis of room-temperature vdW ferromagnets has not been achieved commercially, owing to the imprecise control of the layer-by-layer growth, high-temperature synthesis, and low yield. To overcome these limitations, herein, an artificial vdW ferromagnetic platform has been reported, which activates the nano-crystallization and its corresponding ferromagnetism in bulk VSe 2 via Ar + H 2 S plasma sulfurization. Sweeping the magnetic field, vdW ferromagnetism has been spatially resolved, which experimentally correlates with magnetization reversal behavior and domain pinning effects. Furthermore, nano-crystallization of VSe 2 is clearly validated with transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and selected area diffraction analysis. In conclusion, it is envisioned that the artificial vdW ferromagnetic platform can artificially inject the ferromagnetism in bulk vdW VSe 2 , which has not been possible previously.}, archive = {J_ADVS}, author = {Jinhyoung Lee and Gunhyoung Kim and Hyunho Seok and Hyunbin Choi and Hyeonjeong Lee and Seokchan Lee and Geonwook Kim and Hyunho Kim and Seowoo Son and Sihoon Son and Dongho Lee and Hosin Hwang and Hyelim Shin and Sujeong Han and Geumji Back and Alexina Ollier and Yeon-Ji Kim and Lei Fang and Gyuho Han and Goo-Eun Jung and Youngi Lee and Hyeong-U Kim and Kenji Watanabe and Takashi Taniguchi and Wonjun Shin and Suraj Cheema and Andreas Heinrich and Won-Jun Jang and Taesung Kim}, doi = {10.1002/advs.202504746}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04746}, shortjournal = {Adv. Sci.}, title = {Artificial room-temperature ferromagnetism of bulk van der waals VSe2}, volume = {12}, year = {2025}, }
• (2025). Gut parabacteroides distasonis-derived indole-3-acetic acid promotes phospholipid remodeling and enhances ferroptosis sensitivity via the AhR-FASN axis in bladder cancer. ADVS, 12(34), e04688. (www)

  @article{ , abstract = {The development of bladder cancer is a complex, multistep process influenced by both genetic and environmental factors, but its exact etiology remains unclear. Increasing evidence suggests that gut microbiota dysregulation can impact the initiation and progression of cancers, including colorectal cancer, breast cancer, and pancreatic cancer. This study observes that the beneficial gut bacterium Parabacteroides distasonis ( P. distasonis ) is significantly decreased in bladder cancer patients, and its low abundance is strongly associated with poor prognosis. P. distasonis is a next-generation probiotic which plays a vital role in human health. Furthermore, this work finds that P. distasonis culture medium inhibits metastasis and proliferation of bladder cancer cells in vitro and in vivo. This work identifies that indole-3-acetic acid (3-IAA) produced by P. distasonis exerting similar tumor-suppressive effects. Mechanistically, 3-IAA activates the aryl hydrocarbon receptor (AhR), which in turn downregulates fatty acid synthase (FASN) transcription in bladder cancer cells. Notably, the reduction of FASN expression decreases the ratio of MUFAs to PUFAs, thereby increasing ferroptosis sensitivity in bladder cancer cells. Collectively, this study demonstrates that P. distasonis -derived 3-IAA can inhibit bladder cancer metastasis and proliferation, highlighting the AhR-FASN axis as a promising therapeutic target to inhibit bladder cancer progression.}, archive = {J_ADVS}, author = {Weijia Li and Wentai Shangguan and Wenxue Huang and Jie Zhao and Yuexuan Zhu and Ming Xie and Yao Yu and Qishen Yang and Jun Zheng and Lin Yang and Qi Sun and Leqian Li and Xinhang Shi and Yongyuan Xiao and Hai Huang and Bisheng Cheng and Peng Wu}, doi = {10.1002/advs.202504688}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04688}, shortjournal = {Adv. Sci.}, title = {Gut parabacteroides distasonis-derived indole-3-acetic acid promotes phospholipid remodeling and enhances ferroptosis sensitivity via the AhR-FASN axis in bladder cancer}, volume = {12}, year = {2025}, }
• (2025). Directional ion transport through nanoarchitected 1D mesochannels: 2D polymer interfacial engineering for high-efficiency capacitive deionization. ADVS, 12(34), e04527. (www)

  @article{ , abstract = {The development of high-performance capacitive deionization (CDI) electrodes demands innovative materials that integrate rapid ion transport, high salt adsorption capacity (SAC), and oxidative stability. This challenge is addressed through a surface nanoarchitectonics strategy, constructing 2D mesochannel polypyrrole/reduced graphene oxide heterostructures (mPPy/rGO) with ordered 1D mesochannels (~8 nm) parallel to the graphene surface. By confining the self-assembly of cylindrical polymer brushes on freestanding rGO substrates, directional ion highways are simultaneously engineered that significantly reduce transport tortuosity. In addition, corrosion-resistant polymer interfaces block oxygen penetration, and strong interfacial interactions between PPy and rGO ensure efficient electron transfer. The mPPy/rGO-based CDI cell achieves breakthrough performance: ultrahigh SAC of 84.1 mg g −1 (4.5× activated carbon, the salt concentration: 2 g L −1 ), and 96.8% capacity retention over 100 cycles in air-equilibrated saline solution (the salt concentration: 500 mg L −1 ). This interfacial confinement methodology establishes a universal paradigm for designing polymer-based desalination materials with atomically precise transport pathways.}, archive = {J_ADVS}, author = {Chen Tang and Hongli Chen and Qian Li and Changle Li and Ying Li and Azhar Alowasheeir and Zeinhom M El-Bahy and Guoxiu Wang and Chongyin Zhang and Yusuke Yamauchi and Xingtao Xu}, doi = {10.1002/advs.202504527}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04527}, shortjournal = {Adv. Sci.}, title = {Directional ion transport through nanoarchitected 1D mesochannels: 2D polymer interfacial engineering for high-efficiency capacitive deionization}, volume = {12}, year = {2025}, }
• (2025). Intestinal clock promotes cognitive memory through adenosine signaling. ADVS, 12(34), e04526. (www)

  @article{ , abstract = {Although the intestinal clock (the circadian timing system in the gastrointestinal tract) is known to direct a wide variety of diurnal nutrients and metabolites, its role in the functioning of extra-intestinal tissues such as the brain remains elusive. Here the role of the intestinal clock in shaping cognitive function is investigated. It is found that Bmal1 -iKO mice (mice with Bmal1 [ Brain and muscle Arnt-like protein 1 ] specifically knocked out in the intestine, a mouse line deficient in intestinal clock function) show a defect in cognitive memory irrespective of the time-of-day. Bmal1 -iKO-associated cognitive decline is attributed to impaired adenosine signaling and compromised long-term potentiation (LTP) in the hippocampus. Adenosine signaling promotes LTP via enhancing BDNF expression and inhibiting synapse loss. Furthermore, the impairment in adenosine signaling is accounted for by the reductions in intestinal absorption of and hippocampal level of adenosine but not by a change in adenosine receptors. Consistently, adenosine supplementation rescues cognitive deficits associated with the malfunction of the intestinal clock. Moreover, BMAL1 regulates the expression of ADK (adenosine kinase, a primary enzyme for adenosine clearance) in the small intestine and thus promotes intestinal adenosine absorption through REV-ERBα which binds directly to Adk P2 promoter to inhibit its transcription. Together, an unsuspected role of the intestinal clock in controlling cognitive memory is identified, highlighting the intestinal clock as a promising target for the management of cognitive disorders.}, archive = {J_ADVS}, author = {Min Chen and Fugui Zhang and Yifei Xiao and Xuejun Jiang and Zhiqian Yan and Jinyi Wang and Xiting Lv and Jialu Cui and Linna Ha and Hui Chen and Yongkang Dang and Zifei Qin and Jing Yang and Baojian Wu}, doi = {10.1002/advs.202504526}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04526}, shortjournal = {Adv. Sci.}, title = {Intestinal clock promotes cognitive memory through adenosine signaling}, volume = {12}, year = {2025}, }
• (2025). Microwave-driven dielectric-magnetic regulation of graphite@α-MnO2 toward enhanced electromagnetic wave absorption. ADVS, 12(34), e04489. (www)

  @article{ , abstract = {The advancement of wireless communication technologies necessitates materials that absorb electromagnetic waves and shield against electromagnetic interference. The research is propelled by the necessity to develop materials that possess both properties. Here, an electromagnetic wave-absorbing material that synergistically regulates dielectric and magnetic properties is developed. The material features a nanowire fabric/multilayer composite structure of expanded graphite@α-MnO 2 (EG@MO). The manganese oxide nanowires are prepared in situ on the surface of multilayer expanded graphite via microwave-assisted hydrothermal synthesis. A rapid microwave activation process is subsequently performed to convert manganese oxide-hydroxide, elevating its oxidation state, and transforming it from a non-magnetic form to the magnetic α-MnO 2 . The EG@MO exhibits exceptional electromagnetic wave absorption capabilities, achieving a reflection loss value of −75.56 dB, with a low filler ratio of 7 wt.% and an ultrathin thickness of 1.48 mm. This high-performance electromagnetic absorption material, fabricated by integrating magnetic manganese dioxide nanowires with multilayer expanded graphite, shows excellent widespread applications.}, archive = {J_ADVS}, author = {Junyu Lu and Lei Xu and Cheng Xie and Chang Zhang and Zhaohui Han and Yiyao Ren and Renchao Che}, doi = {10.1002/advs.202504489}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04489}, shortjournal = {Adv. Sci.}, title = {Microwave-driven dielectric-magnetic regulation of graphite@α-MnO2 toward enhanced electromagnetic wave absorption}, volume = {12}, year = {2025}, }
• (2025). Hollow cholesteric liquid crystal elastomer fiber with synergistically enhanced resilience and mechanochromic sensitivity. ADVS, 12(34), e04487. (www)

  @article{ , abstract = {Mechanochromic cholesteric liquid crystal elastomer (CLCE) are unique anisotropic rubbers with programmable optical properties in response to external stimuli, bringing considerable interest in display, sensing, and smart textiles. However, creating mechanochromic CLCE fibers with high sensitivity, excellent resilience, and stable color-changing reversibility is still a challenge. This work describes mechanochromic CLCE symmetric hollow fibers with excellent radial helix alignment prepared by solvent evaporation-induced assembly and template assistance. The cylindrical symmetry renders the response identical in all directions perpendicular to the fiber axis. The hollow fibers show mechanochromic ability in the full visible spectrum, a large wavelength blueshift of 2.25 nm·% −1 under low strain. Excellent mechanochromic reversibility of 100 cycles and resilience are both devoted by cross-linking structure in the wall layer, which also contributes to reversible orientation-recovery of liquid crystal units during stretching-recovery cycles. Numerical models and experimental measurements demonstrate the hollow structure enabled fibers to produce air pressure inside when being stretched, and the fiber wall layer is subjected to greater stress compared to solid fibers, thus achieving high mechanochromic sensitivity. In addition, hollow fiber can still change color when subjected to the expansion stress inside the cavity, and programmable information display in fabric prolongs its application in intelligent textiles.}, archive = {J_ADVS}, author = {Wenwen Wang and Weijie Cheng and Feixia Liu and Kangyu Jia and Huihui Zhan and Chenguang Yang and Ke Liu and Qiongzhen Liu and Dong Wang}, doi = {10.1002/advs.202504487}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04487}, shortjournal = {Adv. Sci.}, title = {Hollow cholesteric liquid crystal elastomer fiber with synergistically enhanced resilience and mechanochromic sensitivity}, volume = {12}, year = {2025}, }
• (2025). Nasal delivery of engineered exosomes via a thermo-sensitive hydrogel depot reprograms glial cells for spinal cord repair. ADVS, 12(34), e04486. (www)

  @article{ , abstract = {Spinal cord injury (SCI) presents formidable therapeutic challenges due to its multifaceted pathological complexity. Here, this work reports engineered macrophage-derived exosomes overexpressing GNA12 and GNA13 (G12G13MExos) that reprogram macrophages toward the M2c anti-inflammatory phenotype and astrocytes into a neuroprotective phenotype. G12G13MExos enhance astrocyte-mediated clearance of myelin debris, glutamate homeostasis, and synapse formation while fostering astrocyte-neuron crosstalk. These effects improve neuronal survival and drove neural stem cell differentiation into V2a neurons, facilitating neural circuit reconstruction. This work develops a chitosan-based thermosensitive hydrogel that functions as a “nasal exosome intelligent slow-release depot” to enable efficient and targeted exosome delivery. This delivery system bypasses hepatic and renal sequestration and overcomes the blood-spinal cord barrier, significantly enhancing therapeutic efficacy. This strategy integrates engineered exosomes with a responsive delivery platform, modulating the inflammatory microenvironment, enhancing cellular crosstalk, and promoting neural repair. This comprehensive approach offers a promising translational avenue for SCI treatment and other central nervous system disorders.}, archive = {J_ADVS}, author = {Yangyang Wang and Jingsong Liu and Pengfei Li and Zhibin Peng and Yubo Zhang and Yishu Liu and Mi Li and Xuqiang Gong and Daqian Liu and Enze Xu and Hongbo Yang and Yuanliang Sun and Yan Xu and Yansong Wang}, doi = {10.1002/advs.202504486}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04486}, shortjournal = {Adv. Sci.}, title = {Nasal delivery of engineered exosomes via a thermo-sensitive hydrogel depot reprograms glial cells for spinal cord repair}, volume = {12}, year = {2025}, }
• (2025). Theranostic toolbox for neutrophil functionalization. ADVS, 12(34), e04412. (www)

  @article{ , abstract = {Neutrophils are crucial for fighting invading pathogens and for the clearance of sterile wounds. However, in cases of overwhelming pathogens or excessive inflammatory responses, fine-tuning of neutrophil functions can help to either enhance bacterial killing or prevent unwanted tissue damage. Thus, the present study is aimed at developing a nanoparticle-based toolbox to direct neutrophils toward either a proinflammatory or reparative phenotype tailored to the specific inflammatory environment. For this, neutrophil-specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background-free 19 F MRI-based theranostic approach are engineered. It is demonstrated that with this i) distinct effector functions can be specifically modulated in both murine and human neutrophils, ii) the disease-specific degree of neutrophil infiltration can be non-invasively monitored in vivo, and in turn iii) neutrophil effector functions can either be attenuated during a pharmacological challenge or amplified to ameliorate tissue damage during bacteria-driven acute colitis. Thus, this nanotheranostic approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to improve disease course and outcome, thus paving the way for a personalized neutrophil immunotherapy.}, archive = {J_ADVS}, author = {Pascal Bouvain and Kay-Matthias Thomy and Anika Maria Prinz and Bodo Steckel and Shiwa Kadir and Alexandra Röhs and Jonas Schmitz and Claudia Dohle and Matthias Karg and Maria Grandoch and Ulrich Flögel and Sebastian Temme}, doi = {10.1002/advs.202504412}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04412}, shortjournal = {Adv. Sci.}, title = {Theranostic toolbox for neutrophil functionalization}, volume = {12}, year = {2025}, }
• (2025). Predictable self-assembly as an unexplored key factor influencing membrane separation: Insights from monophenols. ADVS, 12(34), e04322. (www)

  @article{ , abstract = {While nanofiltration (NF) holds promise for separating small molecules, effectively separating structurally similar compounds like monophenols remains challenging. This study unveils a novel NF separation strategy based on the often-overlooked phenomenon of solute self-assembly. Using a combination of experimental and computational approaches, a direct link between monophenol self-assembly and rejection behavior during NF is established. The self-assembly of monophenols, primarily driven by π–π stacking interactions, is shown to significantly influence their rejection rates, with larger, more numerous self-assemblies experiencing higher rejection. Furthermore, a clear relationship between monophenol structures and self-assembly strength is established, revealing that the number and Hydrogen (H)-bonding capacity of substituents on the aromatic ring dictate the propensity for self-assembly. This insight enables the development of a predictive model for monophenol self-assembly, which is validated through NF experiments using binary mixtures, confirming that predictable differences in self-assembly behavior can be leveraged for selective separation. This study establishes solute self-assembly as a tunable parameter for enhancing NF separation of similarly sized molecules.}, archive = {J_ADVS}, author = {Qiuyu Han and Lu Yin and Tingting Mi and Qi Chen and Wanlin Ouyang and Liping Fan and Qinshi Wang and Yue Zhang and Zhishu Tang and Huaxu Zhu and Bo Li}, doi = {10.1002/advs.202504322}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04322}, shortjournal = {Adv. Sci.}, title = {Predictable self-assembly as an unexplored key factor influencing membrane separation: Insights from monophenols}, volume = {12}, year = {2025}, }
• (2025). SMYD3 promotes immune evasion in clear cell renal cell carcinoma via SREBP1-mediated transactivation of CD47. ADVS, 12(34), e04200. (www)

  @article{ , abstract = {Cancer cell-intrinsic features (e.g., genetic aberrations and dysregulation of signaling pathways) play pivotal roles in orchestrating the composition and functional state of the immune landscape, which in turn impact tumor progression and response to immunotherapy. Here, it is discovered that dysregulation of cancer cell-intrinsic SET and MYND domain-containing protein 3 (SMYD3) leads to the orchestration of an immunosuppressive microenvironment and the impairment of responses to PD-1 blockade by reprogramming the infiltration of immune cells in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). SMYD3 cooperates with Sp1 to transcriptionally promote sterol regulatory element-binding protein 1 (SREBP1) expression by modifying H3-K4 di-/trimethylation and consequently activating the transcription of CD47. CD47, a bridge between innate and adaptive immunity, acts as the downstream effector molecule of the SMYD3 signal to promote the infiltration of T helper 2 (Th2) cells, protecting renal cancer cells from immune attack. In summary, the critical role of the cancer cell-intrinsic SMYD3-SREBP1-CD47 axis is elucidated in regulating the immune microenvironment in ccRCC and provides a potential therapeutic strategy to manipulate the tumor immune milieu in favor of antitumor immunity.}, archive = {J_ADVS}, author = {Zhengfang Liu and Xiumei Zhao and Maolin Zang and Huiyang Yuan and Xin Qin and Xiaofeng Li and Shuo Zhao and Ruirong Tan and Keqiang Yan and Li Liu and Yidong Fan and Ning Zhang and Benkang Shi and Bo Han and Shouzhen Chen}, doi = {10.1002/advs.202404200}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04200}, shortjournal = {Adv. Sci.}, title = {SMYD3 promotes immune evasion in clear cell renal cell carcinoma via SREBP1-mediated transactivation of CD47}, volume = {12}, year = {2025}, }
• (2025). Brachyury-activated fucoidan hydrogel microspheres rejuvenate degenerative intervertebral discs microenvironment. ADVS, 12(34), e04195. (www)

  @article{ , abstract = {Extracellular matrix (ECM) metabolic disorders and the establishment of inflammatory microenvironment are the primary pathological alterations associated with intervertebral disc degeneration (IVDD). The inflammatory microenvironment promotes ECM degradation, further exacerbating the vicious cycle of nucleus pulposus (NP) degeneration. This study introduces the mRNA encoding a novel therapeutic transcription factor, Brachyury (Bry), into nucleus pulposus cells (NPCs) using an injectable microsphere system composed of biomimetic GelMA/Fucoidan (FU) dual-component hydrogel (GF) and surface chemically grafted lipid nanoparticles (LNP) (BLNP@GF). The study aims to alleviate inflammatory response in the NP while restoring the ECM secretion function of NPCs and enhancing the ability of NPCs to withstand inflammatory stress, thereby restoring physiological balance in the NP microenvironment. The GF microspheres demonstrate injectability and porosity, facilitating efficient LNP loading through chemical grafting. In the LPS-simulated inflammatory microenvironment, sustained release of FU significantly reduces inflammatory activity in NPCs. Successful transfection with Bry mRNA upregulate ECM synthesis in degenerated NPCs. In a rat tail puncture IVDD model, local application of BLNP@GF microspheres effectively improved ECM remodeling in NP tissue, thereby ameliorating puncture-induced IVDD. In conclusion, FU-functionalized GelMA hydrogel microspheres loaded with Bry mRNA provide a promising new strategy for reversing IVDD.}, archive = {J_ADVS}, author = {Yuhao Gong and Wenxiao Shi and Xingzhu Liu and Hang Yu and Yinghui Wu and Yanzhang Xia and Caichun Yue and Chongkai Yang and Cong Shen and Renjun Pei and Tianwen Xin and Hailong Pei and Jun Shen}, doi = {10.1002/advs.202504195}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04195}, shortjournal = {Adv. Sci.}, title = {Brachyury-activated fucoidan hydrogel microspheres rejuvenate degenerative intervertebral discs microenvironment}, volume = {12}, year = {2025}, }
• (2025). Cu‒S covalent bonds enable the anchoring of single-atom cu on layered MoS2 for highly selective and active photothermal catalytic conversion of CO2−H2O to ethanol. ADVS, 12(34), e04167. (www)

  @article{ , abstract = {The catalytic conversion of CO 2 into high-value C 2+ products offers a sustainable path toward carbon neutrality. However, traditional photocatalytic and thermal catalytic methods face challenges like low selectivity and yields. Herein, a novel Cu/MoS 2 photothermal catalyst is synthesized via a two-step hydrothermal method, anchoring single-atom Cu on layered MoS 2 for CO 2 and H 2 O reduction into C 2 products (ethanol, acetylene, and ethane). Under optimal conditions (250 °C, 903 mW·cm −2 , 320–780 nm), the Cu 5% –MoS 2 catalyst achieves an ethanol yield of 3.1 mmol·g −1 ·h −1 , 4.6 times higher than blank MoS 2 . Mechanistic studies reveal that Cu improves light absorption and enhances CO 2 adsorption and *COOH accumulation at MoS 2 edge S sites, as confirmed by density functional theory (DFT) calculations. Mo–Cu dual sites stabilize *CHO intermediates, boosting C 2 product selectivity. The synergistic photothermal effect accelerates charge migration and surface reactions. This work provides cost-effective insights into photothermal CO 2 conversion for fuel production.}, archive = {J_ADVS}, author = {Yingao Luo and Gaoli Chen and Zhongliao Wang and Sujuan Zhang and Xiuzhen Zheng and Sugang Meng and Shifu Chen}, doi = {10.1002/advs.202504167}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04167}, shortjournal = {Adv. Sci.}, title = {Cu‒S covalent bonds enable the anchoring of single-atom cu on layered MoS2 for highly selective and active photothermal catalytic conversion of CO2−H2O to ethanol}, volume = {12}, year = {2025}, }
• (2025). In situ programming of the tumor microenvironment to alleviate immunosuppression for pancreatic cancer immunotherapy. ADVS, 12(34), e04008. (www)

  @article{ , abstract = {Recent studies have highlighted the pivotal role of the cGAS-STING pathway in cancer immunotherapy. However, clinical trials with cGAS-STING pathway agonists have faced setbacks thanks to their short biological half-life, lack of tumor specificity, and potential to promote tumor immune evasion. To address these challenges, a novel exosome-based drug delivery platform, termed cmExo aCD11b is developed, designed to precisely target and reprogram the tumor microenvironment (TME) in situ for pancreatic cancer immunotherapy. cmExo aCD11b is engineered to encapsulate high copy numbers of IL-12 mRNA and 2′3’-cGAMP (cGAMP) and is functionalized with CD11b antibodies for targeted delivery to macrophages. Notably, cmExo aCD11b facilitated the repolarization of M2 macrophages to M1 phenotype, thereby reprogramming the TME and enhancing the secretion of pro-inflammatory cytokines. This immunomodulatory effect reversed the immunosuppressive milieu of the TME and significantly inhibited tumor progression. More importantly, cmExo aCD11b exhibited robust therapeutic efficacy in both murine pancreatic cancer and patient-derived xenograft models. These results suggest that cmExo aCD11b represents a promising approach for overcoming immunosuppression in pancreatic cancer, paving the way for its potential application in cancer immunotherapy.}, archive = {J_ADVS}, author = {Man Sun and Huan Zhang and Yarui Ma and Simiao Wang and Jiayi Chen and Yaxin Cui and Yun Zhang and Siyuan Hu and Dan Zhou and Pengchen Zhang and Yahui Liu and Betty Y.S. Kim and Wen Jiang and Xiaobing Wang and Zhaogang Yang}, doi = {10.1002/advs.202504008}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e04008}, shortjournal = {Adv. Sci.}, title = {In situ programming of the tumor microenvironment to alleviate immunosuppression for pancreatic cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Amyloid forming human lysozyme intermediates are stabilized by non-native amide-π interactions. ADVS, 12(34), e03957. (www)

  @article{ , abstract = {Mutational variants of human lysozyme cause a rare but fatal hereditary systemic amyloidosis by populating an intermediate state that self-assembles into amyloid fibrils. However, this intermediate state is recalcitrant to detailed structural investigation, as it is only transiently and sparsely populated. Here, this work investigates the intermediate state of an amyloid-forming human lysozyme variant (I59T) using CEST and CPMG RD NMR at low pH. 15 N CEST profiles probe the thermal unfolding of the native state into the denatured ensemble and reveal a distinct intermediate state. Global fitting of 15 N CEST and CPMG data provides kinetic and thermodynamic parameters, characterizing the intermediate state populated at 0.6%. 1 H CEST data further confirm the presence of the intermediate state displaying unusually high or low 1 H N chemical shifts. To investigate the structural details of this intermediate state, this work uses molecular dynamics (MD) simulations, which recapitulate the experimentally observed folding pathway and free energy landscape. This work observes a high-energy intermediate state with a locally disordered β-domain and C-helix, stabilized by non-native hydrogen bonding and amide-π interactions, accounting for its anomalous 1 H chemical shifts. Together, these NMR and MD data provide the first direct structural information on the intermediate state, offering insights into targeting lysozyme amyloidosis.}, archive = {J_ADVS}, author = {Minkoo Ahn and Julian O. Streit and Christopher A. Waudby and Tomasz Włodarski and Angelo Miguel Figueiredo and John Christodoulou and Janet R. Kumita}, doi = {10.1002/advs.202503957}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03957}, shortjournal = {Adv. Sci.}, title = {Amyloid forming human lysozyme intermediates are stabilized by non-native amide-π interactions}, volume = {12}, year = {2025}, }
• (2025). Carbonyls mediated dual-function enables high-performance carbon anodes in ester-based electrolyte. ADVS, 12(34), e03954. (www)

  @article{ , abstract = {Constructing an “ether solid electrolyte interphase (SEI)”-like layer in ester electrolyte is highly attractive to realize excellent capacity and cycling stability for hard carbon anode, but has barely been mentioned yet. Herein, the hard carbon grafted by caffeic acid is developed via a surface reconstruction strategy, in which rich C═O moieties are introduced. Varied characterizations reveal that the existing C═O exhibits stronger adsorption energy on salt (PF 6 − ) than solvent (e.g., EC and DEC), thus accelerating salt decomposition to produce a stable inorganic SEI layer. Besides, C═O moieties can also adsorb K-ions reversibly, accounting for a high capacitive contribution. Benefiting from the double merits of C═O moieties, the interfacial stability and surface properties of the optimized sample are greatly improved, and as a result, the reversible capacity can reach 462.7 mAh g −1 (0.1 A g −1 over 50 cycles) and rate performance is quite superior as well (321.8 mAh g −1 at 2 A g −1 ). Besides, a prolonged cycle life of over 2000 cycles is smoothly realized at 2 A g −1 in ester-based electrolytes. This work provides insight into the electrochemical performance improvement of ester-based electrolytes via structure design.}, archive = {J_ADVS}, author = {Ziyu Wu and Fei Yuan and Siyu Wu and Di Zhang and Qiujun Wang and Qujiang Sun and Zhaojin Li and Wei Wang and Bo Wang}, doi = {10.1002/advs.202503954}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03954}, shortjournal = {Adv. Sci.}, title = {Carbonyls mediated dual-function enables high-performance carbon anodes in ester-based electrolyte}, volume = {12}, year = {2025}, }
• (2025). Wireless soft athlete bioelectronics for monitoring carbon dioxide ventilation and physiological performance. ADVS, 12(34), e03880. (www)

  @article{ , abstract = {Wearable devices have become essential tools for monitoring athletes' health and performance. However, most current devices are primarily designed to track physiological signals and physical indicators, which limits their ability to assess a comprehensive range of health parameters during exercise. Therefore, there is a need for a multimodal wearable platform that can capture diverse exercise-related metrics. Here, a wireless soft athlete bioelectronic system is presented that monitors various physiological signals and metabolites during exercise. This system includes a smart-sensing lip guard that detects ventilated carbon dioxide, osmolality, environmental conditions, and humidity—key indicators of the metabolites expelled from the nose and mouth. Additionally, the cardiac patch complements the lip guard by monitoring multiple signals, such as electrocardiograms, heart rates, temperature, and motion. This integrated system is capable of detecting exercise-induced conditions such as dehydration, hyperventilation, and abnormal heart signals. By combining data from both physiological and environmental factors, the wearable device offers a comprehensive assessment of how external conditions influence an athlete's performance. Evaluating the device with human subjects under varying temperature conditions demonstrates its effectiveness in observing exercise performance, regardless of environmental factors, highlighting its significant potential for enhancing athlete healthcare and performance monitoring.}, archive = {J_ADVS}, author = {Tae Woog Kang and Ka Ram Kim and Yoon Jae Lee and Hodam Kim and Sung Hoon Lee and Youngjin Kwon and Hoon Yi and Hojoong Kim and Hyeonseok Kim and Alec Harp and Jud Ready and Melinda Millard-Stafford and Woon-Hong Yeo}, doi = {10.1002/advs.202503880}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03880}, shortjournal = {Adv. Sci.}, title = {Wireless soft athlete bioelectronics for monitoring carbon dioxide ventilation and physiological performance}, volume = {12}, year = {2025}, }
• (2025). USP8-governed MDA5 homeostasis promotes innate immunity and autoimmunity. ADVS, 12(34), e03865. (www)

  @article{ , abstract = {The essential cytoplasmic RNA sensor Melanoma Differentiation-Associated protein 5 (MDA5) initiates type I interferons (IFNs) signaling and subsequent immune responses. However, aberrant activation of MDA5 by viral infections or gain-of-function mutations leads to severe autoimmune diseases, for most of which effective treatment is limited. Here, it is shown that inactivation of ubiquitin-specific protease 8 (USP8/UBPy) degrades the MDA5 protein, suppressing antiviral signaling and autoimmunity. It is found that viral infection modulates the AKT-dependent phosphorylation of USP8 at serine 718, which not only promotes the activation of USP8 but also enhances the association between USP8 and MDA5 and the consequent deubiquitination and stabilization of MDA5. Inactivation of USP8 specifically degrades the MDA5 protein regardless of the mutation pattern. Genetic deletion of Usp8 in mice contributes to decreased levels of type I interferons and proinflammatory cytokines. Importantly, inhibition of USP8 or AKT can effectively suppress MDA5-induced autoimmunity in Aicardi–Goutières syndrome (AGS) mice and anti-MDA5-positive dermatomyositis (DM)/systemic lupus erythematosus (SLE) patient cells. Therefore, these results highlight the critical roles of USP8 in innate antiviral immunity against RNA viruses and autoimmunity and provide a potential therapy for treating autoimmune diseases associated with MDA5.}, archive = {J_ADVS}, author = {Qimin Zhang and Shan Huang and Yan He and Weiwei Wang and Chao Tong and Mengru Ma and Manyu Zhao and Lian Yi and Klaus-Peter Knobeloch and Peijing Zhang}, doi = {10.1002/advs.202503865}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03865}, shortjournal = {Adv. Sci.}, title = {USP8-governed MDA5 homeostasis promotes innate immunity and autoimmunity}, volume = {12}, year = {2025}, }
• (2025). HIGD1A alleviates oxidative stress related ovarian hypofunction by enhancing granulosa cell functions via NF-κB/SOD2 signaling pathway. ADVS, 12(34), e03828. (www)

  @article{ , abstract = {Diminished ovarian reserve (DOR) is a physiological or pathological condition that progresses in an age-dependent manner, which is characterized by impaired ovarian follicle quality, decreased anti-Müllerian hormone levels, elevated follicle-stimulating hormone levels, and reduced antral follicle counts. Oxidative stress (OS) is one of the culprits of DOR. By imposing OS damage on various kinds of ovarian cells including granulosa cells, OS can result in ovarian hypofunction and eventually lead to female infertility. However, the underlying mechanisms have not been fully elucidated yet. In this study, HIGD1A, a mitochondrial inner membrane component, is found to be downregulated in granulosa cells upon OS exposure. By systematically studying the role of HIGD1A in regulating granulosa cell and ovarian functions as well as its corresponding mechanisms, a novel regulatory mechanism underlying OS-related female infertility is revealed, and provided a potential molecular target for anti-OS therapies.}, archive = {J_ADVS}, author = {Huiying Li and Siying Cai and Hongbei Mu and Tianli Chang and Xiaofei Wang and Tianyu Tang and Tengyun Dong and Yu Zhang and Ling Zhang and Huaibiao Li and Liquan Zhou and Wenpei Xiang}, doi = {10.1002/advs.202503828}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03828}, shortjournal = {Adv. Sci.}, title = {HIGD1A alleviates oxidative stress related ovarian hypofunction by enhancing granulosa cell functions via NF-κB/SOD2 signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Electrocatalytic hydrogen oxidation by defect-enriched CuW nanoalloy featuring hydrogen spillover effect. ADVS, 12(34), e03710. (www)

  @article{ , abstract = {The development of efficient alkali-resistant non-noble metal electrocatalysts for hydrogen (H 2 ) oxidation reaction (HOR) is crucial for advancing the hydrogen economy. Recently, the hydrogen spillover effect has been proven to be one of the vital means to enhance the activity of the HOR catalyst. In this report, a facile and controllable electrodeposition strategy is proposed for synthesizing a tungsten (W)-doped copper (Cu) nanoalloy/WO 3 electrocatalyst with abundant metal-metal heterointerfaces to promote hydrogen spillover, i. e., the migration of * H from W/WO 3 sites to Cu substrates. CuW grown in situ on carbon paper (CP) demonstrates exceptional HOR performance (1.86 mA cm −2 at 0.05 V vs. RHE) and remarkable stability in alkaline media. XAFS and density functional theory (DFT) calculations confirm that alloying W atoms into the Cu lattice induces electronic modulation, significantly boosting the adsorption, decomposition, and oxidation of H 2 . The migration of * H from W/WO 3 sites to Cu sites via the hydrogen spillover effect has been validated by in - situ Fourier transform infrared (FT-IR) and Raman spectra. This study may open up a new path for designing high-efficiency HOR electrocatalysts from the perspective of appropriate hydrogen spillover channel design.}, archive = {J_ADVS}, author = {Bingyan Xiong and Lisong Chen and Jianlin Shi}, doi = {10.1002/advs.202503710}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03710}, shortjournal = {Adv. Sci.}, title = {Electrocatalytic hydrogen oxidation by defect-enriched CuW nanoalloy featuring hydrogen spillover effect}, volume = {12}, year = {2025}, }
• (2025). Hexokinase-2 as a therapeutic target: Alleviating herpes simplex keratitis through metabolic reprogramming. ADVS, 12(34), e03690. (www)

  @article{ , abstract = {Herpes simplex keratitis (HSK) is a leading infectious cause of blindness worldwide, with current therapies primarily targeting viral replication rather than addressing host-cell injury. RNA sequencing of corneal tissue from HSK patients and healthy donors identifies a metabolic shift from mitochondrial oxidative phosphorylation to aerobic glycolysis. Notably, hexokinase-2 (HK2), a pivotal glycolytic enzyme, exhibits the greatest up-regulation, coinciding with a marked reduction in the activity of mitochondrial respiratory chain complexes in HSK corneas. Pharmacological inhibition of HK2 with lonidamine in human corneal epithelial cells reduces herpes simplex virus type 1 (HSV-1) replication while preserving cell viability. In a murine model of HSK, topical lonidamine restored respiratory-chain activity, lowered viral load, and accelerated corneal re-epithelialization; its early therapeutic efficacy surpassed that of ganciclovir, and combination therapy conferred additive benefit. These findings identify HK2-driven glycolytic reprogramming as a pathogenic hallmark of HSK and demonstrate that metabolic targeting concurrently restricts viral propagation and promotes tissue regeneration. Thus, metabolic intervention has the potential to complement direct antiviral therapy and represents a promising, clinically translatable strategy to preserve vision in HSK.}, archive = {J_ADVS}, author = {Dan Jiang and Yining Sun and Xintong Yu and Ruoqi Wang and Yuting Zhang and Jinjie Yu and Shuang Xie and Yujia Cai and Yuhong Luo and Wei Chen}, doi = {10.1002/advs.202503690}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03690}, shortjournal = {Adv. Sci.}, title = {Hexokinase-2 as a therapeutic target: Alleviating herpes simplex keratitis through metabolic reprogramming}, volume = {12}, year = {2025}, }
• (2025). DNase I-mediated chemotactic nanoparticles for NETs targeting and microenvironment remodeling treatment of acute ischemic stroke. ADVS, 12(34), e03689. (www)

  @article{ , abstract = {The recruitment and formation of neutrophil extracellular traps (NETs) by neutrophils play an important role in reperfusion injury in ischemic stroke. Current nanosystem-based therapeutic strategies are mainly confined within the blood-brain barrier (BBB), ignoring the constant intrusion from external challenges. Here, considering the unique vascular localization of NETs, a DNase I-mediated NETs-targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and external microenvironment of the neurovascular unit (NVU). DNase I navigates the nanoparticles to the lesion, enabling the accumulation in the brain through damaged BBB. The removal of intravascular NETs mitigates the ongoing destruction of the endothelium and reduces the recruitment of immunothrombosis. The main nanoparticles with dual antioxidant activity rescue neuronal apoptosis by scavenging reactive oxygen species (ROS) and protecting mitochondria. Reduced infarct size and remodeling of microenvironment homeostasis shown in the middle cerebral artery occlusion/reperfusion (MCAO) mouse model. This strategy provides new insights into the vascular side treatment of ischemic stroke. Targeting mediated by enzyme chemotaxis is first validated and showed the potential of a universal chemotactic targeted delivery strategy.}, archive = {J_ADVS}, author = {Tongyu Zhang and Peixin Liu and Wenru Shen and Chao Li and Zhenhao Zhao and Yuxing Wu and Tao Sun and Chen Jiang}, doi = {10.1002/advs.202503689}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03689}, shortjournal = {Adv. Sci.}, title = {DNase I-mediated chemotactic nanoparticles for NETs targeting and microenvironment remodeling treatment of acute ischemic stroke}, volume = {12}, year = {2025}, }
• (2025). High-sensitivity perovskite γ-ray detectors enhanced by device engineering toward energy spectroscopy imaging. ADVS, 12(34), e03597. (www)

  @article{ , abstract = {Perovskite-based detectors for γ-rays have emerged relatively recently and have attracted limited attention. Although increasing efforts are being directed towards their development, the absence of an adaptive processor, systematic theoretical framework, and various applications limit its further development. In this paper, drawing inspiration from the commercial detectors, electrode configuration is improved to reshape the bias electric field, guide the effective signal carrier, and mitigate the noise from the side section. Through theoretical analysis, simulations, and experimental comparisons, the clear improvement of energy resolution from 7% to ≈5% is demonstrated, and the highest resolution of 1.9% is observed. Furthermore, to fill up the research framework of radiation, the definition of X-ray sensitivity is extended to quantitatively describe the γ-ray response, and assess the performance of γ-ray detectors, reaching a sensitivity ≈10 5 µC Gy air −1 cm −2 . Based on these, a spectral-enhanced imaging strategy is proposed to broaden the application of γ-Ray detectors, where the spectral dimension of images is utilized to improve contrast and enhance imaging quality.}, archive = {J_ADVS}, author = {Ken Qin and Jia-He Zhang and Ruo-Long Zhou and Xue Sun and He-Xuan Wang and Jia-Li Peng and Min-Shu Zhang and Guan-Hua Dun and Dan Xie and He Tian and Yi Yang and Tian-Ling Ren}, doi = {10.1002/advs.202503597}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03597}, shortjournal = {Adv. Sci.}, title = {High-sensitivity perovskite γ-ray detectors enhanced by device engineering toward energy spectroscopy imaging}, volume = {12}, year = {2025}, }
• (2025). RAB5A promotes active fluid wetting by reprogramming breast cancer spheroid mechanics. ADVS, 12(34), e03569. (www)

  @article{ , abstract = {Unjamming transitions from a solid-like to a fluid-like state are a gateway to breast epithelial cancer invasion. However, the mechanical interplay between phase transitions and dimension transitions, in particular wetting, remains elusive, despite being critical for understanding the onset of metastatic dissemination. This study shows that unjamming, mediated by the RAB5A GTPase, alters carcinoma spheroid fluidity, rigidity, and rewires adhesion mechanics to drive supracellular active wetting as a new mode of tumor expansion. Spheroid fluidification enhances the selective expression of integrin subunits and increases focal adhesion dynamics, inducing a fluid-like spreading behavior on specific matrix ligands. Notably, nanoscale regulation of integrin clustering can select for distinct phase transitions at the collective scale upon wetting. In this framework, fluidized spheroids polarize into cohesive “supracells”, and maintain a stiff peripheral actin bundle as measured by nanomechanical mapping. Furthermore, a combination of Brillouin microscopy and 2.5D traction force analysis reveals a mechanical switch within the spheroid core, characterized by significant cell softening and a reduction in compressive forces exerted on the substrate, thereby mimicking the wetting of a liquid droplet. These findings establish unjamming-driven active wetting as a key mechanism to comprehend the molecular and biophysical underpinnings of solid tumor invasion.}, archive = {J_ADVS}, author = {Grégoire Lemahieu and Paulina Moreno-Layseca and Tobias Hub and Carlo Bevilacqua and Manuel Gómez-González and Federica Pennarola and Federico Colombo and Andrew E. Massey and Leonardo Barzaghi and Andrea Palamidessi and Leon-Luca Homagk and Samuel F. H. Barnett and Alexander X. Cartagena-Rivera and Christine Selhuber-Unkel and Robert Prevedel and Xavier Trepat and Joachim P. Spatz and Johanna Ivaska and Giorgio Scita and Elisabetta Ada Cavalcanti-Adam}, doi = {10.1002/advs.202503569}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03569}, shortjournal = {Adv. Sci.}, title = {RAB5A promotes active fluid wetting by reprogramming breast cancer spheroid mechanics}, volume = {12}, year = {2025}, }
• (2025). LncDARS-AS1 regulates ATP1A1 stability and enhances Na+/K+ ATPase activity to promote osteosarcoma metastasis. ADVS, 12(34), e03486. (www)

  @article{ , abstract = {Osteosarcoma, the most prevalent malignant bone tumour in children and adolescents, exhibits aggressive pulmonary metastasis and poor prognosis. This study identifies LncDARS-AS1 as a key regulator of metastasis via modulation of ATP1A1, the catalytic subunit of Na⁺/K⁺ ATPase (NKA). Transcriptomic analyses, validated by qPCR in 217 osteosarcoma RNA samples, reveal that LncDARS-AS1 is significantly upregulated in metastatic lesions and associated with adverse clinical outcomes. Functional assays confirm that silencing LncDARS-AS1 suppresses osteosarcoma proliferation and metastasis in vitro and in vivo. Mechanistically, LncDARS-AS1 directly binds ATP1A1, preventing its interaction with the UBQLN4 and subsequent proteasomal degradation, thereby enhancing NKA activity. Protein-RNA interactions were validated using ChIRP, mass spectrometry, molecular docking, and molecular dynamics simulations. Functional NKA activity was assessed using ion-sensitive fluorescent indicators and enzymatic assays. Additionally, digoxin, a cardiac glycoside targeting NKA, effectively inhibited tumour growth and metastasis at clinically safe concentrations. These findings uncover a novel LncDARS-AS1/ATP1A1 axis that promotes osteosarcoma metastasis through inhibition of ubiquitin-mediated degradation and provide a rationale for repurposing digoxin in osteosarcoma therapy. ATP1A1 emerges as a promising target for anti-metastatic intervention.}, archive = {J_ADVS}, author = {Mingxian Xu and Jiatian Wei and Xiaoyu Feng and Qinkai Zhang and Jian Chen and Xinyue Wang and Xiudan Zhan and Bing Lu and Weitang Guo and Mingzhe Cheng and Renxuan Huang and Shao Xu and Changye Zou}, doi = {10.1002/advs.202503486}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03486}, shortjournal = {Adv. Sci.}, title = {LncDARS-AS1 regulates ATP1A1 stability and enhances Na+/K+ ATPase activity to promote osteosarcoma metastasis}, volume = {12}, year = {2025}, }
• (2025). 3D-printing of electroconductive MXene-based micro-meshes in a biomimetic hyaluronic acid-based scaffold directs and enhances electrical stimulation for neural repair applications. ADVS, 12(34), e03454. (www)

  @article{ , abstract = {No effective treatments are currently available for central nervous system neurotrauma although recent advances in electrical stimulation suggest some promise in neural tissue repair. It is hypothesized that structured integration of an electroconductive biomaterial into a tissue engineering scaffold can enhance electroactive signaling for neural regeneration. Electroconductive 2D Ti 3 C 2 T x MXene nanosheets are synthesized from MAX-phase powder, demonstrating excellent biocompatibility with neurons, astrocytes and microglia. To achieve spatially-controlled distribution of these MXenes, melt-electrowriting is used to 3D-print highly-organized PCL micro-meshes with varying fiber spacings (low-, medium-, and high-density), which are functionalized with MXenes to provide highly-tunable electroconductive properties (0.081 ± 0.053-18.87 ± 2.94 S/m). Embedding these electroconductive micro-meshes within a neurotrophic, immunomodulatory hyaluronic acid-based extracellular matrix (ECM) produced a soft, growth-supportive MXene-ECM composite scaffold. Electrical stimulation of neurons seeded on these scaffolds promoted neurite outgrowth, influenced by fiber spacing in the micro-mesh. In a multicellular model of cell behavior, neurospheres stimulated for 7 days on high-density MXene-ECM scaffolds exhibited significantly increased axonal extension and neuronal differentiation, compared to low-density scaffolds and MXene-free controls. The results demonstrate that spatial-organization of electroconductive materials in a neurotrophic scaffold can enhance repair-critical responses to electrical stimulation and that these biomimetic MXene-ECM scaffolds offer a promising new approach to neurotrauma repair.}, archive = {J_ADVS}, author = {Ian Woods and Dahnan Spurling and Sandra Sunil and Anne Marie O'Callaghan and Jack Maughan and Javier Gutierrez-Gonzalez and Tara K. McGuire and Liam Leahy and Adrian Dervan and Valeria Nicolosi and Fergal J. O'Brien}, doi = {10.1002/advs.202503454}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03454}, shortjournal = {Adv. Sci.}, title = {3D-printing of electroconductive MXene-based micro-meshes in a biomimetic hyaluronic acid-based scaffold directs and enhances electrical stimulation for neural repair applications}, volume = {12}, year = {2025}, }
• (2025). Adiponectin assists thrombopoietic agents in ITP treatment by enhancing myosin-9/Rab6A-mediated trafficking of c-mpl in MKs. ADVS, 12(34), e03008. (www)

  @article{ , abstract = {Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by accelerated platelet destruction and defective platelet production. The thrombopoietin (TPO)-activated c-Mpl signaling pathway has been proven to promote megakaryocyte differentiation and platelet production and thus has significant value in the clinical treatment of ITP. However, individual differences and unsustainable responses limit the clinical application of c-Mpl agonists. The cell membrane distribution of c-Mpl is crucial for the cell response to c-Mpl agonists. In the present study, this is observed that the distribution of c-Mpl on the megakaryocyte membrane is significantly reduced in ITP patients. The reduction is more severe in refractory patients. Then, this is verified that the membrane trafficking of c-Mpl is mediated by the Myosin-9/Rab6A complex, and demonstrates that the stability of this complex depends on Rab6A-GTPase. Furthermore, this is found that adiponectin promotes the membrane localization of c-Mpl by increasing the expression of Rab6A GEFs. Finally, this is revealed that adiponectin can assist thrombopoietic agents in the treatment of ITP mice. The results clarify the c-Mpl distribution defects in the cell membrane and the corresponding c-Mpl membrane transport mechanisms in megakaryocytes of ITP, providing new insights to improve the clinical efficacy of thrombopoietic agents for ITP patients.}, archive = {J_ADVS}, author = {Xin Zhao and Huixian Ma and Guosheng Li and Jilong Xiao and Zhiyu Shi and Mingying Li and Xinguang Liu and Tao Sun and Chunyan Ji}, doi = {10.1002/advs.202503008}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e03008}, shortjournal = {Adv. Sci.}, title = {Adiponectin assists thrombopoietic agents in ITP treatment by enhancing myosin-9/Rab6A-mediated trafficking of c-mpl in MKs}, volume = {12}, year = {2025}, }
• (2025). PRO-LDM: A conditional latent diffusion model for protein sequence design and functional optimization. ADVS, 12(34), e02723. (www)

  @article{ , abstract = {The diffusion model has grasped enormous attention in the computer vision field and emerged as a promising algorithm in protein design for precise structure and sequence generation. Here PRO-LDM is introduced: a modular multi-tasking framework combining design fidelity and computational efficiency, by integrating the diffusion model in latent space. The model learns biological representations at local and global levels, to design natural-like species with enhanced diversity, or optimize protein properties and functions. Its modular nature also enables the integration with alternative pre-trained encoders for enhanced generalization capability. Outlier design can be implemented by adjusting the classifier-free guidance that enables PRO-LDM to sample vastly different regions in the latent space. The approach is demonstrated in generating a novel green-fluorescence-protein variant with notably enhanced fluorescence in multiple working scenarios along with increased solubility and stability. The model provides a versatile tool to effectively extract physicochemical and evolutionary information in sequences for designing new proteins with optimized performances.}, archive = {J_ADVS}, author = {Sitao Zhang and Zixuan Jiang and Rundong Huang and Wenting Huang and Siyuan Peng and Shaoxun Mo and Letao Zhu and Peiheng Li and Ziyi Zhang and Emily Pan and Xi Chen and Yunfei Long and Qi Liang and Jin Tang and Renjing Xu and Rui Qing}, doi = {10.1002/advs.202502723}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e02723}, shortjournal = {Adv. Sci.}, title = {PRO-LDM: A conditional latent diffusion model for protein sequence design and functional optimization}, volume = {12}, year = {2025}, }
• (2025). Probing the challenge of P-type semiconductors in long-chain VOC detection: 3D micro-flower zinc cobaltate heterojunction sensors. ADVS, 12(34), e02646. (www)

  @article{ , abstract = {Tetradecane, a long-chain alkane recently recognized as a volatile marker for early-stage mildew detection in stored grains and as a reference material in hydrocarbon studies, presents significant challenges for detection due to its inherent low reactivity and substantial molecular size. This study reports the synthesis of a microflower-like Fe@WO 3 / ZnCo 2 O 4 heterostructure for effective tetradecane sensing. The Fe@WO 3 / ZnCo 2 O 4 n-p junctions demonstrated significant alterations in electrical conductivity upon exposure to tetradecane at room temperature. The sensor achieved a reasonable detection limit of 78.4 ppb and a rapid recovery time of 36 s. The remarkable sensing performance is attributed to the synergistic interactions among multiple heterojunction interfaces, doping-induced active sites, the presence of oxygen vacancies, high-energy crystallographic facets, reduced grain size, and enhanced crystallinity, as supported by density functional theory calculations and molecular dynamics simulations. This work identifies a promising candidate for the detection of distinct volatile organic compounds, warranting further exploration in agricultural and emission monitoring applications while addressing a critical gap in metal oxide semiconductor sensors for the detection of large-molecule gases.}, archive = {J_ADVS}, author = {Kewei Liu and Zichen Zheng and Yiwen Zhou and Carla Bittencourt and Marc Debliquy and Chao Zhang}, doi = {10.1002/advs.202502646}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e02646}, shortjournal = {Adv. Sci.}, title = {Probing the challenge of P-type semiconductors in long-chain VOC detection: 3D micro-flower zinc cobaltate heterojunction sensors}, volume = {12}, year = {2025}, }
• (2025). Quantitative electron beam-single atom interactions enabled by sub-20-pm precision targeting. ADVS, 12(34), e02551. (www)

  @article{ , abstract = {The ability to probe and control matter at the picometer scale is essential for advancing quantum and energy technologies. Scanning transmission electron microscopy offers powerful capabilities for materials analysis and modification, but sample damage, drift, and scan distortions hinder single atom analysis and deterministic manipulation. Materials analysis and modification via electron–solid interactions can be transformed by precise delivery of electrons to a specified atomic location, maintaining the beam position despite drift, and minimizing collateral dose. Here a fast, low-dose, sub-20-pm precision electron beam positioning technique is developed, “atomic lock-on,” (ALO), which offers the ability to position the beam on a specific atomic column without previously irradiating that column. This technique is used to lock onto a single selected atomic location to repeatedly measure its weak electron energy loss signal despite sample drift. Moreover, electron beam-matter interactions in single atomic events are measured with time resolution. This enables observation of single-atom dynamics, such as atomic bistability, revealing partially bonded atomic configurations and recapture phenomena. This opens prospects for using electron microscopy for high-precision measurements and deterministic control of matter for quantum technologies.}, archive = {J_ADVS}, author = {Kevin M. Roccapriore and Frances M. Ross and Julian Klein}, doi = {10.1002/advs.202502551}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e02551}, shortjournal = {Adv. Sci.}, title = {Quantitative electron beam-single atom interactions enabled by sub-20-pm precision targeting}, volume = {12}, year = {2025}, }
• (2025). Collapsing the bottleneck by interfacial effect of Ni/CeO2 for long-term hydrogen production using waste alkaline water in practical-scale anion exchange membrane water electrolyzer. ADVS, 12(34), e02484. (www)

  @article{ , abstract = {The demand for hydrogen production compels the development of various strategies for water splitting. Among these strategies, the Anion Exchange Membrane Water Electrolyzer (AEMWE) offers the advantages such as low cost and the production of high-purity hydrogen. Waste alkaline water generated from various industries can be directly used in the AEMWE system, due to its appropriate pH range of 13–14. While various nickel-based hydrogen evolution reaction (HER) electrocatalysts have demonstrated adequate performance, their long-term stability remains a concern. To ensure long-term stability of AEMWE, it is crucial to address the potential poisoning effects of impurities present in waste alkaline water on nickel-based HER electrocatalysts. In this study, the Ni-CeO₂/Carbon (NCC) catalyst is employed for HER in waste alkaline water containing Li, Mo, and W ions. NCC exhibited an overpotential of 31 mV, showing ≈3 times less overpotential compared to the Ni/C. The XPS results and DFT calculations demonstrated the electrons transferring from CeO 2 to Ni, inducing the Electronic Metal-Support Interactions (EMSI) effects. The NCC shows 1 A cm −2 at 2.03 V in AEMWE while Ni/C needed 2.33 V to achieve the same current densities. The NCC maintaines long-term stability over 2000 h, with a degradation rate of 4.95%.}, archive = {J_ADVS}, author = {Nam In Kim and Jaehun Lee and Song Jin and Jaehoon Jeong and Shin-Woo Myeong and Jun Seok Ha and Junyoung Park and Hoseok Lee and Minjeong Park and Chiho Kim and Sungjun Kim and Seok Hwan Yang and Yoo Sei Park and Jooyoung Lee and Jang Yong Lee and Min Ho Seo and Sung Mook Choi}, doi = {10.1002/advs.202502484}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e02484}, shortjournal = {Adv. Sci.}, title = {Collapsing the bottleneck by interfacial effect of Ni/CeO2 for long-term hydrogen production using waste alkaline water in practical-scale anion exchange membrane water electrolyzer}, volume = {12}, year = {2025}, }
• (2025). Bacteria optimize tumble bias to strategically navigate surface constraints. ADVS, 12(34), e02063. (www)

  @article{ , abstract = {In natural environments, solid surfaces present both opportunities and challenges for bacteria. On one hand, they serve as platforms for biofilm formation, crucial for bacterial colonization and resilience in harsh conditions. On the other hand, surfaces can entrap bacteria for extended periods and force them to swim along circular trajectories, constraining their environmental exploration compared to the freedom they experience in the bulk liquid. Here, through systematic single-cell behavioral measurements, phenomenological modeling, and theoretical analysis, how bacteria strategically navigate these factors is revealed. It is observed that bacterial surface residence time decreases sharply with increasing tumble bias from zero, transitioning to a plateau at the mean tumble bias of wild-type Escherichia coli (≈0.25). Furthermore, it is found that bacterial surface diffusivity peaks near this mean tumble bias. Considering the phenotypic variation in bacterial tumble bias, which is primarily induced by noise in gene expression, this reflects a strategy for bacterial offspring persistence: In the absence of stimulus cues, some bacteria swiftly escape from the nearby surface in case it lacks nutrients, while others, with longer surface residence times, explore this 2D environment most efficiently to find potential livable sites.}, archive = {J_ADVS}, author = {Antai Tao and Guangzhe Liu and Rongjing Zhang and Junhua Yuan}, doi = {10.1002/advs.202502063}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e02063}, shortjournal = {Adv. Sci.}, title = {Bacteria optimize tumble bias to strategically navigate surface constraints}, volume = {12}, year = {2025}, }
• (2025). Activation of kir4.1 channels by 2-d08 promotes myelin repair in multiple sclerosis. ADVS, 12(34), e02032. (www)

  @article{ , abstract = {Multiple sclerosis (MS) is a chronic inflammatory disease that leads to myelin loss and neurological dysfunction. Clinical studies show increased anti-Kir4.1 antibody levels in MS patients' serum, indicating its diagnostic potential. However, the specific mechanism has remained elusive. In a mouse model of experimental autoimmune encephalomyelitis (EAE), it is found that impaired Kir4.1 channels in oligodendrocyte precursor cells (OPCs) hindered myelin repair in the spinal cord. Using a thermal shift assay (TSA), the small molecule 2-D08 is identified, which effectively activated Kir4.1 channels and reduced demyelination in both EAE mice and marmosets. The neuroprotective effects are mainly due to enhanced phosphorylation of FYN tyrosine kinase, promoting OPCs differentiation. The findings highlight the critical role of Kir4.1 channels in MS pathogenesis and suggest that pharmacological activation of these channels by 2-D08 can be a promising therapeutic strategy for enhancing brain recovery in demyelinating diseases.}, archive = {J_ADVS}, author = {Mingdong Liu and Shengyu Jin and Xin Fu and Chong Xie and Yi Chen and Liangtang Chang and Yongheng Fan and Donghua He and Xiaoqi Hong and Xi Shen and Xiaoli Zheng and Qiyue Wang and Dao Shi and Fangyuan Li and Daishun Ling and Yangtai Guan and Neng Gong and Xiaoping Tong}, doi = {10.1002/advs.202502032}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e02032}, shortjournal = {Adv. Sci.}, title = {Activation of kir4.1 channels by 2-d08 promotes myelin repair in multiple sclerosis}, volume = {12}, year = {2025}, }
• (2025). Histone demethylase UTX suppresses tumor cell proliferation by regulating stress granules. ADVS, 12(34), e01990. (www)

  @article{ , abstract = {UTX (also known as KDM6A) is a histone H3K27 demethylase that acts as an important tumor regulator. UTX has been reported to participate in genome-wide histone modifications and gene expression in tumorigenesis and its mutations are identified in human cancers. Here, UTX is demonstrated to localize both in the cytoplasm and nucleus, notably, cytoplasmic UTX forms puncta and co-localizes in stress granules (SGs) upon different stresses in vitro. Mechanistically, the TPR domain of UTX plays a critical role in regulating SG disassembly by interacting with G3BP1, the central hub of SG, to disrupt the scaffold network of SG under endoplasmic reticulum stress. Importantly, a clinical UTX mutation, D336G in TPR domain, increases cytoplasmic location of UTX, and stabilizes SG. While UTX D336G promotes, WT UTX or UTX TPR inhibits, cell growth and tumorigenesis by regulating SGs both in vitro and in nude mice, and such regulation is G3BP1 dependent. Together, the results suggest a novel cytoplasmic function of UTX as a negative regulator of SG homeostasis, which is involved in stress and disease states such as tumorigenesis.}, archive = {J_ADVS}, author = {Xikai Liu and Xinran Liu and Mei Xue and Yushuo Xiao and Yuchen Chen and Rong Qiu and Di Wu and Yihao Zhou and Jiao Wang and Yan Yuan and Linwei Yu and Tianyi Shi and Yangkai Li and Hua Su and Hong Chen and Yong Liu and Kun Huang and Ling Zheng}, doi = {10.1002/advs.202501990}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e01990}, shortjournal = {Adv. Sci.}, title = {Histone demethylase UTX suppresses tumor cell proliferation by regulating stress granules}, volume = {12}, year = {2025}, }
• (2025). FLASH irradiation modulates immune responses and accelerates lung recovery: A single-cell perspective. ADVS, 12(34), e01797. (www)

  @article{ , abstract = {Radiation therapy (RT) is essential for treating thoracic malignancies but often causes significant lung damage. FLASH-RT, an ultra-high dose rate irradiation technique, shows potential in reducing radiation-induced lung injury (RILI) while maintaining tumor control. However, the underlying immune mechanisms remain poorly understood. This study investigates the immune and cellular responses to FLASH-RT versus conventional dose rate (CONV) RT during the early phase of RILI. Using single-cell RNA sequencing (scRNA-seq), a dynamic landscape of the lung microenvironment is pictured during RILI within one-week post-irradiation. The analysis reveals that FLASH-RT induces a more immediate but transient cellular response, while CONV-RT causes sustained inflammation. FLASH irradiation significantly reduces neutrophil infiltration compared to CONV irradiation, particularly within the pro-inflammatory Ccrl2 + subset. FLASH irradiation also triggers stronger activation of CD4 + CD40L + Th cells, which are critical for regulating immune responses and balancing inflammation. Moreover, FLASH irradiation attenuates pro-inflammatory activation and intercellular signaling of Mefv⁺ monocytes, thereby restraining excessive macrophage-driven inflammation. Additionally, FLASH irradiation enhances TGF-β signaling and epithelial-mesenchymal transition (EMT) in alveolar type 1 (AT1) cells, promoting tissue repair. These findings highlight FLASH-RT's superior immune modulation and reparative potential, providing valuable insights into its clinical application for minimizing radiation damage and enhancing lung recovery.}, archive = {J_ADVS}, author = {Hao Lu and Menghua Li and Cheng Quan and Caihui Li and Dawei Li and Zhihui Li and Jing Xu and Lihui Zhang and Qixiang Liu and Guofu Dong and Changzhen Wang}, doi = {10.1002/advs.202501797}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e01797}, shortjournal = {Adv. Sci.}, title = {FLASH irradiation modulates immune responses and accelerates lung recovery: A single-cell perspective}, volume = {12}, year = {2025}, }
• (2025). Post-translational modified neoantigens in autoimmune diseases: Challenges of immune tolerance. ADVS, 12(34), e01766. (www)

  @article{ , abstract = {Autoimmune diseases, like spondyloarthritis (SpA) and rheumatoid arthritis (RA), have a high incidence and disability rate and are major diseases that seriously endanger human health. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post-translational modified neoantigens are the key nodal of these three factors. Under the intervention of the external environment, changes in metabolic status in vivo induce metabolite-related post-translational modifications (PTMs). These PTM proteins and peptides, after being presented by human leukocyte antigen (HLA) molecules of specific genotypes, can trigger autoreactive T cell expansions which are antigen-specific and then develop into autoimmunity. Such biological processes are a great challenge to the immune tolerance status and can be an important cause of autoimmune diseases.}, archive = {J_ADVS}, author = {Yue Zhai and Kefei Wu and Qi Lin and Zhenzhen Cao and Yankun Jia and Ping Zhu}, doi = {10.1002/advs.202501766}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e01766}, shortjournal = {Adv. Sci.}, title = {Post-translational modified neoantigens in autoimmune diseases: Challenges of immune tolerance}, volume = {12}, year = {2025}, }
• (2025). Coactosin-like protein reduces prostaglandin d2 production in alveolar macrophages and alleviates allergic airway inflammation. ADVS, 12(34), e01673. (www)

  @article{ , abstract = {Allergic asthma is a significant global health issue characterized by chronic airway inflammation. Current treatments only alleviate symptoms but fail to cure the disease due to its complex pathology. Lipid mediators from arachidonate metabolism are pivotal in immune regulation in asthma. Previously, coactosin-like protein (CLP) is identified as a regulator of leukotriene production in vitro. However, its role in asthma is unclear. In this study, it is found that CLP-deficient ( Cotl1 −/− ) mice challenged with house dust mite (HDM) exhibits exacerbated airway inflammation, macrophage polarization, and type 2 immune responses. CLP deficiency increased prostaglandin D 2 (PGD 2 ) in bronchoalveolar lavage (BAL) and alveolar macrophages (AMs), activating the PGD 2 receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) on immune cells. Notably, HDM exposure reduced pulmonary CLP levels in wild-type (WT) mice, and overexpression of CLP in Cotl1 −/− macrophages decreased HDM-induced PGD 2 in BAL and alleviated inflammation. Cotl1 −/− AMs exacerbated HDM-induced airway inflammation compared to WT AMs, and this effect is dependent on CRTH2 signaling. These findings reveal that CLP modulates macrophage polarization and suppresses the PGD 2 -CRTH2 pathway to alleviate airway inflammation, highlighting CLP as a promising therapeutic target for asthma.}, archive = {J_ADVS}, author = {Li-Long Pan and Zhengnan Ren and Binbin Li and Wenjie Liang and Yang Luo and Qin Yang and He Liu and Xiaoliang Dong and Haizhi Tian and Huimin Zou and Bengt Samuelsson and Olof Rådmark and Jia Sun}, doi = {10.1002/advs.202501673}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e01673}, shortjournal = {Adv. Sci.}, title = {Coactosin-like protein reduces prostaglandin d2 production in alveolar macrophages and alleviates allergic airway inflammation}, volume = {12}, year = {2025}, }
• (2025). Gut metabolite indole-3-propionic acid regulates macrophage autophagy through PPT1 inhibiting aging-related myocardial fibrosis. ADVS, 12(34), e01070. (www)

  @article{ , abstract = {Cardiac fibrosis, a key pathological feature of cardiac remodeling, is a major contributor to mortality in older patients with heart failure. The underlying mechanisms are complex, involving alterations in intercellular communication and chronic inflammation. This study investigates the role of indole-3-propionic acid (IPA) in aging-related myocardial fibrosis and its regulatory effects on autophagy through palmitoyl-protein thioesterase 1 (PPT1). Here, plasma levels of IPA, a tryptophan-derived metabolite, are found to be reduced in older patients with heart failure, and this reduction is associated with deteriorating cardiac function. Notably, IPA supplementation significantly attenuated aging-related myocardial fibrosis. PPT1, a lysosomal enzyme involved in autophagy, is upregulated in macrophages during aging. IPA reversed aging-induced increase in PPT1 expression. Using PPT1 flox/flox Lyz2-cre mice, it is demonstrated that macrophage-specific deletion of PPT1 significantly reduced cardiac inflammation and myocardial fibrosis in aged mice. Furthermore, PPT1 silencing in macrophages reduced the expression of myocardial fibrosis markers in vitro. Mechanistically, IPA regulated PPT1 expression to modulate the PI3K-AKT-mTOR pathway, thereby restoring autophagic activity in senescent macrophages and suppressing both inflammation and aging-related myocardial fibrosis. Additionally, IPA influenced the cGAS-STING signaling pathway to regulate PPT1 expression. These findings demonstrate that IPA inhibits PPT1, activates autophagy in macrophages, and mitigates aging-related myocardial fibrosis.}, archive = {J_ADVS}, author = {Jing Lu and Hongyan Wang and Haiyu Zhang and Jiahao Li and Hanqi Li and Qiuyu Chen and Dongyu Han and Jialiang Liu and Lin Lv and Jie Xiong and Keying Yuan and Xianpeng Wei and Siqi Sheng and Fukai Liu and Yuanqi Shi and Zengxiang Dong and Yue Li}, doi = {10.1002/advs.202501070}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e01070}, shortjournal = {Adv. Sci.}, title = {Gut metabolite indole-3-propionic acid regulates macrophage autophagy through PPT1 inhibiting aging-related myocardial fibrosis}, volume = {12}, year = {2025}, }
• (2025). PFKM-driven lactate overproduction promotes atrial fibrillation via triggering cardiac fibroblasts histone lactylation. ADVS, 12(34), e00963. (www)

  @article{ , abstract = {Increasing evidence has clarified that atrial fibrillation (AF) is associated with enhanced glycolysis, leading to lactate accumulation. However, whether glycolysis promotes AF remains unknown, as does whether histone lactylation plays a role in its pathogenesis. In the study, spontaneous AF mice are established to monitor AF susceptibility and atrial substrates at different ages (3, 5, 7 months), indicating that enhanced glycolysis acts as a promoter during AF development by inducing atrial fibrosis. The promoting effect of glycolysis on AF and the pivotal enzyme in driving glycolysis are confirmed by treatment with glycolysis inhibitor 2-deoxyglucose (2-DG) and adeno-associated virus-mediated atrial PFKM expression. Furthermore, lactate stimulates primary mouse cardiac fibroblast (CF) activation. Mechanistically, the observations indicated that atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300-mediated H3K18 lactylation up-regulates TGF-β1 transcription, leading to activation of CF, and thereby contributing to atrial fibrosis. The results reveal a novel role of the metabolic-epigenetic axis in AF pathogenesis, which raises the possibility of potential therapeutic strategies targeting AF.}, archive = {J_ADVS}, author = {Ning Fang and Ning Zhang and Xiaohui Jiang and Sen Yan and Zhiqi Wang and Qianhui Gao and Mingcheng Xu and Lin Mu and Xiaoming Li and Jiuling Chen and Song Zhang and Yu Duan and Fengxiang Yun and Luyifei Li and Yun Zhang and Yongtai Gong}, doi = {10.1002/advs.202500963}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e00963}, shortjournal = {Adv. Sci.}, title = {PFKM-driven lactate overproduction promotes atrial fibrillation via triggering cardiac fibroblasts histone lactylation}, volume = {12}, year = {2025}, }
• (2025). Auxin-producing pseudomonas recruited by root flavonoids increases rice rhizosheath formation through the bacterial histidine kinase under soil drying. ADVS, 12(34), e00607. (www)

  @article{ , abstract = {Rhizosheath formation is facilitated by root hair length, root exudates, the soil microbes, which collectively enhance plant resistance to drought. This process partly results from the complex interaction between root exudates and microbes, a relationship that remains poorly understood. The roles of root exudates and microbes in rhizosheath formation in rice under soil drying (SD) conditions are investigated. In tetraploid rice, rhizosheath formation under SD is approximately 70% greater than in diploid rice. Inoculation of diploid rice with the rhizosheath soil microbiota from tetraploid rice significantly enhanced rhizosheath formation under SD. The bacterial genus Pseudomonas is identified as the key taxon promoting rhizosheath formation in tetraploid rice under SD. Tetraploid rice exhibits significantly higher root flavonoid concentration than diploid rice under SD. Overexpression of the chalcone synthase gene ( OsCHS1 ), a key gene involved in flavonoid biosynthesis, led to a significant increase in the abundance of Pseudomonadaceae in diploid rice. Pseudomonas nitroreducens , isolated from the rhizosheath of tetraploid rice, demonstrates chemotactic attraction to flavonoids, but this behavior is not observed in histidine kinase mutant Δ cheA . Diploid and tetraploid rice inoculated with P. nitroreducens and IAA biosynthesis complemented strain Δ iaaM -c formed larger rhizosheath under SD than those inoculated with its IAA biosynthesis mutant Δ iaaM . These results suggest that auxin-producing Pseudomonas , recruited by root flavonoids, enhances rice rhizosheath formation through the bacterial histidine kinase under SD. This finding may facilitate the improvement of environmental adaptation in polyploidy crops by regulating their interactions with beneficial soil microorganisms.}, archive = {J_ADVS}, author = {Feiyun Xu and Yongsen Wang and Jinyong Yang and Xue Zhang and Ke Wang and Fan Ding and Jiayin Pang and Lu Tong and Chuqi Bai and Shu Chen and Leyun Sun and Chongxuan Du and Ju Fang and Mengqiang Xu and Liang Li and Xin Yu and Jiahong Gengli and Jianping Liu and Qian Zhang and Zhengrui Wang and Yiyong Zhu and Huanyuan Zhang-Zheng and Jianhua Zhang and Weifeng Xu}, doi = {10.1002/advs.202500607}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e00607}, shortjournal = {Adv. Sci.}, title = {Auxin-producing pseudomonas recruited by root flavonoids increases rice rhizosheath formation through the bacterial histidine kinase under soil drying}, volume = {12}, year = {2025}, }
• (2025). Identifying myeloid-derived suppressor cells and lipocalin-2 as therapeutic targets for intervertebral disc degeneration. ADVS, 12(34), e00505. (www)

  @article{ , abstract = {Inflammation is a hallmark of intervertebral disc degeneration (IVDD) characterized by immune cell infiltration and cytokine secretion. Stage-specific transcriptomic analyses of IVDD via single-cell RNA sequencing (scRNA-seq) have primarily focused on nucleus pulposus cell phenotypes but not immune subpopulations. In other disease contexts, integrating genome-wide association studies (GWAS) with scRNA-seq data has provided insights on pathomechanisms in relation to specific cellular subpopulations via single-cell disease relevance scores (scDRS). However, such an approach remains to be applied to IVDD. Here, the stage- specific analysis of IVDD in relation to Pfirrmann grading revealed a key transition in immune cells from a preponderance of LCN2 high myeloid-derived suppressor cells (MDSCs) during early degeneration to a surge of proinflammatory IL1B+ macrophages in advanced IVDD. scDRS implicated IL1B+ M1-like macrophages as a GWAS risk-enriched subpopulation associated with disease, while functional validation indicated an immunomodulatory effect of LCN2 high MDSCs via ANXA1-mediated inflammation suppression. Accordingly, LCN2 knockout mice exhibit accelerated IVDD, whereas recombinant LCN2 promoted macrophage polarization in vitro to the reparative phenotype by enhancing ANXA1 / Arginase-1 expression and countering LPS/IFN-γ-induced pro-inflammatory phenotype. This work identifies LCN2 high MDSCs as an immunoprotective subpopulation in early IVDD and highlights a potential role of LCN2 as a novel therapeutic agent.}, archive = {J_ADVS}, author = {Changmeng Zhang and Haoyun Li and Hongfei Wang and Liangyu Shi and Ying Shing Chan and Yu Wang and Graham Ka Hon Shea}, doi = {10.1002/advs.202500505}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e00505}, shortjournal = {Adv. Sci.}, title = {Identifying myeloid-derived suppressor cells and lipocalin-2 as therapeutic targets for intervertebral disc degeneration}, volume = {12}, year = {2025}, }
• (2025). MYC/TET3-regulated TMEM65 activates OXPHOS-SERPINB3 pathway to promote progression and cisplatin resistance in triple-negative breast cancer. ADVS, 12(34), e00421. (www)

  @article{ , abstract = {Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer due to its aggressive clinical features and the lack of effective targeted therapeutics. Mitochondrial metabolism is intimately linked to TNBC progression and therapeutic resistance and is an attractive therapeutic target for TNBC. Here, it is first reported that human transmembrane protein 65 (TMEM65), a poorly characterized mitochondrial inner-membrane protein-encoding gene in human cancer, acts as a novel oncogene in TNBC to promote tumor growth, metastasis, and cisplatin resistance both in vivo and in vitro. Transcription factor MYC and DNA demethylase ten-eleven translocation 3 (TET3) coordinately upregulate TMEM65 in TNBC, and its upregulation is associated with poor patient survival. Moreover, pharmacological inhibition or knockdown of MYC and TET3 attenuates TMEM65-driven TNBC progression. Mechanistic investigations reveal that TMEM65 enhances mitochondrial oxidative phosphorylation and its byproduct reactive oxygen species (ROS) production. Increased ROS induces the expression of hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates serpin family B member 3 (SERPINB3) to enhance TNBC stemness, thus leading to TNBC progression and cisplatin resistance. Collectively, these findings identify TMEM65 as a vital oncogene of TNBC, unveil its regulatory mechanisms, and shed light on its potential role in TNBC therapy.}, archive = {J_ADVS}, author = {Yin-Ling Zhang and Min-Ying Huang and Shao-Ying Yang and Jia-Yang Cai and Qian Zhao and Fang-Lin Zhang and Xin Hu and Zhi-Min Shao and Li Liao and A-Yong Cao and Da-Qiang Li}, doi = {10.1002/advs.202500421}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {e00421}, shortjournal = {Adv. Sci.}, title = {MYC/TET3-regulated TMEM65 activates OXPHOS-SERPINB3 pathway to promote progression and cisplatin resistance in triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). Artificial room-temperature ferromagnetism of bulk van der waals VSe2 (Adv. sci. 34/2025). ADVS, 12(34), 71526. (www)

  @article{ , archive = {J_ADVS}, author = {Jinhyoung Lee and Gunhyoung Kim and Hyunho Seok and Hyunbin Choi and Hyeonjeong Lee and Seokchan Lee and Geonwook Kim and Hyunho Kim and Seowoo Son and Sihoon Son and Dongho Lee and Hosin Hwang and Hyelim Shin and Sujeong Han and Geumji Back and Alexina Ollier and Yeon-Ji Kim and Lei Fang and Gyuho Han and Goo-Eun Jung and Youngi Lee and Hyeong-U Kim and Kenji Watanabe and Takashi Taniguchi and Wonjun Shin and Suraj Cheema and Andreas Heinrich and Won-Jun Jang and Taesung Kim}, doi = {10.1002/advs.71526}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {71526}, shortjournal = {Adv. Sci.}, title = {Artificial room-temperature ferromagnetism of bulk van der waals VSe2 (Adv. sci. 34/2025)}, volume = {12}, year = {2025}, }
• (2025). Controlling energy flow in perovskite heterostructures through dimensionality and phase engineering (Adv. sci. 34/2025). ADVS, 12(34), 71525. (www)

  @article{ , archive = {J_ADVS}, author = {Danila A. Tatarinov and Alexander Schleusener and Roman Krahne}, doi = {10.1002/advs.71525}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {71525}, shortjournal = {Adv. Sci.}, title = {Controlling energy flow in perovskite heterostructures through dimensionality and phase engineering (Adv. sci. 34/2025)}, volume = {12}, year = {2025}, }
• (2025). An osteoconductive janus hydrogel with full barrier protection and adaptable degradation properties for superior bone regeneration (Adv. sci. 34/2025). ADVS, 12(34), 71524. (www)

  @article{ , archive = {J_ADVS}, author = {Yanhui Lu and Jia Song and Yongle Lv and Boon Chin Heng and Mingming Xu and Ying He and Youde Liang and Lu-Ning Wang and Tingting Wu and Ting Song and Tingjun Li and Qiaomei Ren and Lei Wang and Xuliang Deng and Xuehui Zhang}, doi = {10.1002/advs.71524}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {71524}, shortjournal = {Adv. Sci.}, title = {An osteoconductive janus hydrogel with full barrier protection and adaptable degradation properties for superior bone regeneration (Adv. sci. 34/2025)}, volume = {12}, year = {2025}, }
• (2025). Water-immersed GaP huygens’ meta-optics for visible structured light generation (Adv. sci. 34/2025). ADVS, 12(34), 71523. (www)

  @article{ , archive = {J_ADVS}, author = {Jia-Hua Lee and Hsing-Yi Wang and Pei Ying Ho and Yu Chia Chung and Ruei-Tzu Duh and Cheng-Ching Chiang and Ray-Hua Horng and Yao-Wei Huang and Ming Lun Tseng}, doi = {10.1002/advs.71523}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {71523}, shortjournal = {Adv. Sci.}, title = {Water-immersed GaP huygens’ meta-optics for visible structured light generation (Adv. sci. 34/2025)}, volume = {12}, year = {2025}, }
• (2025). Collapsing the bottleneck by interfacial effect of Ni/CeO2 for long-term hydrogen production using waste alkaline water in practical-scale anion exchange membrane water electrolyzer (Adv. sci. 34/2025). ADVS, 12(34), 71521. (www)

  @article{ , archive = {J_ADVS}, author = {Nam In Kim and Jaehun Lee and Song Jin and Jaehoon Jeong and Shin-Woo Myeong and Jun Seok Ha and Junyoung Park and Hoseok Lee and Minjeong Park and Chiho Kim and Sungjun Kim and Seok Hwan Yang and Yoo Sei Park and Jooyoung Lee and Jang Yong Lee and Min Ho Seo and Sung Mook Choi}, doi = {10.1002/advs.71521}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {71521}, shortjournal = {Adv. Sci.}, title = {Collapsing the bottleneck by interfacial effect of Ni/CeO2 for long-term hydrogen production using waste alkaline water in practical-scale anion exchange membrane water electrolyzer (Adv. sci. 34/2025)}, volume = {12}, year = {2025}, }
• (2025). Lysosome-featured cell aggregate-released extracellular vesicles regulate iron homeostasis and alleviate post-irradiation endothelial ferroptosis for mandibular regeneration (Adv. sci. 34/2025). ADVS, 12(34), 71520. (www)

  @article{ , archive = {J_ADVS}, author = {Yuan-Yuan Li and Bo Ma and Jia-Wei Lu and Kai-Chao Zhang and Chao Ma and Sheng-Feng Bai and Yan-Jiao Li and Si-Qi Ying and Wei-Zong Weng and Kai Zhang and Xi-Wang Hu and Rang Li and Chen-Xi Zheng and Xiao-Ru Xu and Ji Chen and Fang Jin and Hao-Kun Xu and Jian-Wei Xie and Yan Jin and Yi Shuai and Bing-Dong Sui}, doi = {10.1002/advs.71520}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {71520}, shortjournal = {Adv. Sci.}, title = {Lysosome-featured cell aggregate-released extracellular vesicles regulate iron homeostasis and alleviate post-irradiation endothelial ferroptosis for mandibular regeneration (Adv. sci. 34/2025)}, volume = {12}, year = {2025}, }
• (2025). Activation of kir4.1 channels by 2-d08 promotes myelin repair in multiple sclerosis (Adv. sci. 34/2025). ADVS, 12(34), 71519. (www)

  @article{ , archive = {J_ADVS}, author = {Mingdong Liu and Shengyu Jin and Xin Fu and Chong Xie and Yi Chen and Liangtang Chang and Yongheng Fan and Donghua He and Xiaoqi Hong and Xi Shen and Xiaoli Zheng and Qiyue Wang and Dao Shi and Fangyuan Li and Daishun Ling and Yangtai Guan and Neng Gong and Xiaoping Tong}, doi = {10.1002/advs.71519}, journal = {Advanced Science}, month = {9}, number = {34}, pages = {71519}, shortjournal = {Adv. Sci.}, title = {Activation of kir4.1 channels by 2-d08 promotes myelin repair in multiple sclerosis (Adv. sci. 34/2025)}, volume = {12}, year = {2025}, }
• (2025). Generation of high-brilliance polarized γ-rays via vacuum dichroism-assisted vacuum birefringence. ADVS, 12(33), e17201. (www)

  @article{ , abstract = {High-brilliance circularly polarized γ-photon beams are of great significance for a wide range of applications. However, their generation through nonlinear Compton scattering must require a high-density longitudinally-spin-polarized electron beam and consequently is still a great challenge. Here, a novel method is proposed to generate such γ-photon beams via the vacuum dichroism (VD)-assisted vacuum birefringence (VB) effect, only utilizing a well-established unpolarized electron beam. A linearly polarized laser pulse is splitted into two subpulses with the first one colliding with a dense unpolarized electron beam to generate a linearly polarized γ-photon beam (via nonlinear Compton scattering), which then further collides with the second subpulse and is transformed into a circularly polarized one via the VB effect. It is found that by manipulating the relative polarization of two subpulses, one can “purify” the polarization of the γ-photon beam via the VD effect, thereby significantly enhancing the circular polarization of the γ-photon beam. Due to the VD assistance, the VB effect reaches optimal when the relative polarization is nearly 30°, not the widely used 45° in the common VB detection methods. The numerical results show that one can obtain a circularly polarized γ-photon beam with average degree of about 30% (43%) for energies above 500 (1000) MeV and brilliance of about 10 24 (10 23 ) photons/(s · mm 2 · mrad 2 · 0.1%BW) at 500 (1000) MeV by using a currently feasible laser with a peak intensity of about 10 22 Wcm − 2. And, it can be further improved to above 60% (75%) by increasing the laser pulse duration. Moreover, our method is shown to be robust with respect to the laser and electron beam parameters, and can also be used to efficiently confirm the well-known VB effect itself, which has been predicted a very long time ago but has not been directly observed in experiments yet.}, archive = {J_ADVS}, author = {Chong Lv and Feng Wan and Yousef I. Salamin and Qian Zhao and Mamutjan Ababekri and Ruirui Xu and Jian-Xing Li}, doi = {10.1002/advs.202417201}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e17201}, shortjournal = {Adv. Sci.}, title = {Generation of high-brilliance polarized γ-rays via vacuum dichroism-assisted vacuum birefringence}, volume = {12}, year = {2025}, }
• (2025). Microphysiological uremia model reveals biophysical potentiators of vascular dysfunction. ADVS, 12(33), e17091. (www)

  @article{ , abstract = {Cardiovascular disease is a leading cause of mortality in individuals with chronic kidney disease (CKD), with hypertension being a major contributor to both kidney damage and increased cardiovascular risk. Despite the established link between CKD and cardiovascular disease, the role of uremic toxins in monocyte-endothelial interactions under hypertensive conditions remains underexplored. Here, a 3D microfluidic model is developed to examine the effects of indoxyl sulfate on monocyte adhesion and extravasation across engineered microvessels embedded in hydrogels with different densities under controlled luminal pressure. Elevated pressure alone in absence of indoxyl sulfate significantly enhanced monocyte adhesion and extravasation, regardless of matrix density, while matrix density regulated adhesion and transmigration in the uremic environment. ICAM-1 is identified as a key driver of THP-1 monocyte adhesion to the endothelium. Additionally, denser hydrogels primed monocytes toward a pro-inflammatory phenotype with reduced phagocytic capacity, while softer hydrogels induced an anti-inflammatory-like phenotype with enhanced phagocytosis. However, the uremic environment reduced phagocytosis and shifted cells toward a pro-inflammatory-like state, irrespective of matrix density. This approach has the potential to dissect multiple factors that contribute to elevated cardiovascular risks in CKD patients and improve the understanding of mechanisms involved in monocyte dynamics in CKD-related cardiovascular disease.}, archive = {J_ADVS}, author = {Mitesh Rathod and Ryan N. Stack and Sarah E. Kubik and Stephanie A. Huang and Chloe P. Whitworth and Wen Y. Aw and Elizabeth L. Doherty and Sara M. Meehan and Prabir Roy-Chaudhury and William J. Polacheck}, doi = {10.1002/advs.202417091}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e17091}, shortjournal = {Adv. Sci.}, title = {Microphysiological uremia model reveals biophysical potentiators of vascular dysfunction}, volume = {12}, year = {2025}, }
• (2025). Metabolic stress-induced choline kinase α (CHKA) activation in endothelial subpopulation contributes to diabetes-associated microvascular dysfunction. ADVS, 12(33), e17045. (www)

  @article{ , abstract = {Diabetes is a prevalent metabolic disorder, and its associated microvascular dysfunction plays a key role in the pathogenesis of complications such as retinopathy, nephropathy, and peripheral vascular disease. However, the mechanism governing metabolic regulation and functional heterogeneity of endothelial dysfunction remains incompletely understood. This study investigates the role of metabolic stress-induced activation of choline kinase α (CHKA) in endothelial cell (EC) subpopulations, contributing to diabetes-induced microvascular dysfunction. Using single-cell RNA sequencing (scRNA-seq), three distinct EC subclusters are identified within retinal vessels. Among them, one subcluster characterized by elevated CHKA expression is associated with enhanced angiogenic activity. CHKA silencing in ECs inhibited angiogenic effects and reduced retinal vascular dysfunction in diabetic murine models. CHKA silencing also disrupted NAD + metabolism, causing reduced NAD + levels. Supplementation with nicotinamide mononucleotide (NMN), a precursor of NAD + , partially reversed the anti-angiogenic effects induced by CHKA silencing. Mechanistically, CHKA regulated endothelial dysfunction through the NAD + -SIRT1-Notch signaling. Clinical sample analysis and Mendelian randomization studies provided strong evidence linking increased CHKA expression with diabetic microvascular complications. Collectively, this study advances the understanding of endothelial heterogeneity and identifies CHKA as a critical regulator of pathological angiogenesis, highlighting its potential as a therapeutic target for diabetic vascular complications.}, archive = {J_ADVS}, author = {Ling Ren and Linyu Zhang and Yun Bai and Chang Huang and Xiaosa Li and Fanfei Ma and Wan Mu and Mudi Yao and Chang Jiang and Xiangjun Chen and Qin Jiang and Biao Yan}, doi = {10.1002/advs.202417045}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e17045}, shortjournal = {Adv. Sci.}, title = {Metabolic stress-induced choline kinase α (CHKA) activation in endothelial subpopulation contributes to diabetes-associated microvascular dysfunction}, volume = {12}, year = {2025}, }
• (2025). Phosphorylation-dependent stabilization of collaborator of ARF (CARF) suppresses lymphoma cell proliferation. ADVS, 12(33), e16687. (www)

  @article{ , abstract = {Uncontrolled cell proliferation drives tumorigenesis and malignant progression, making cell cycle regulation a promising strategy for cancer therapy. Phosphorylation plays pivotal roles in cancer initiation and metastasis by regulating the cancer-related proteins. Identifying key phosphorylation sites is essential for inhibiting tumor cell proliferation and optimizing therapy strategy. Here, this study reveals the strong association of oncogene Collaborator of ARF (CARF), a cell-division regulator interacting with p53, with prognosis and survival of lymphoma patients through pan-cancer analysis. In addition, this study finds that mammalian CARF shares homology with Kip-Related Protein6 (KRP6), a cell cycle inhibitor from higher plant Arabidopsis . KRP6 is regulated by casein kinase1 via phosphorylation at serines 75 and 109, which are conservative in CARF at serines 316 and 356. Systemic assays conducted with various B-cell lymphoma cell lines and a mouse xenograft model demonstrate that the non-phosphorylation variant of CARF inhibited cell proliferation and lymphoma formation more effectively than wild-type CARF, highlighting the crucial regulatory role of phosphorylation at these conserved sites in controlling B-cell lymphoma cell proliferation. A similar suppressive effect is observed with plant KRP6, suggesting a cross-species bioengineering application. These findings enlighten the application of phosphorylation-modified proteins as therapeutic targets in precise lymphoma treatments.}, archive = {J_ADVS}, author = {Li Qu and Zhuang Wei and Shuting Zhou and Xiaofan Zhang and Wenjun Zhang and Aibin Liang and Zhe Wang and Hongwei Xue}, doi = {10.1002/advs.202416687}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e16687}, shortjournal = {Adv. Sci.}, title = {Phosphorylation-dependent stabilization of collaborator of ARF (CARF) suppresses lymphoma cell proliferation}, volume = {12}, year = {2025}, }
• (2025). A high-fidelity RNA-targeting Cas13X downregulates connexin43 in macroglia: A novel neuroprotective strategy for glaucoma. ADVS, 12(33), e15856. (www)

  @article{ , abstract = {Glaucoma is a neurodegenerative disease characterized by the progressive degeneration of retinal ganglion cells (RGCs) and their axons, ultimately leading to irreversible vision loss. Elevated intraocular pressure (IOP) is one of the significant risk factors in glaucoma; however, neurodegeneration continues even after effective IOP management, underscoring the need for neuroprotective therapies. This study investigates the role of connexin43 (Cx43), which is extensively expressed in retinal macroglia, in regulating microglial activation and optic nerve degeneration in glaucoma. A high-fidelity CRISPR-Cas13 (hfCas13X) system is employed to selectively target and knock down Cx43 expression in macroglia. The findings reveal that Cx43-mediated ATP release through hemichannels exacerbates microglial activation and neuroinflammation, thereby contributing to RGC loss. Notably, in a mouse model of chronic ocular hypertension (COH) glaucoma, knocking down Cx43 in macroglia using the hfCas13X system significantly promoted the survival of RGCs and the integrity of the optic nerve, and improved visual function. The hfCas13X system, which offers high-fidelity RNA editing with minimal off-target effects, represents a novel and promising therapeutic strategy for glaucoma, highlighting the potential of gene editing technologies in the management of neurodegenerative diseases.}, archive = {J_ADVS}, author = {Guoli Zhao and Zhen Li and Ming-Jie Zhao and Shu-Ying Li and Qing Xia and Shuoyu Xu and Yu Zhang and Yi Wang and Fang Li and Yu-Ling Liu and Yun-Hui Guo and Ruo-Xi Xu and Han Zhou and Hong Zhou and Wen-Wen Ding and Yong-Chen Wang and Yanying Miao and Zhongfeng Wang}, doi = {10.1002/advs.202415856}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e15856}, shortjournal = {Adv. Sci.}, title = {A high-fidelity RNA-targeting Cas13X downregulates connexin43 in macroglia: A novel neuroprotective strategy for glaucoma}, volume = {12}, year = {2025}, }
• (2025). Natural allelic variations in IbCHYR1–IbZnFR complex regulate fusarium root rot resistance in sweet potato. ADVS, 12(33), e15202. (www)

  @article{ , abstract = {Sweet potato ( Ipomoea batatas ) is a globally important autohexaploid root and tuber crop. Fusarium root rot threatens its entire growth, harvest, and storage period, thereby reducing yield and quality. Therefore, a deeper understanding of Fusarium pathogenicity and sweet potato defense is urgently required. Here, two single nucleotide polymorphisms are identified within the promoter region of the I. batatas CHY zinc-finger and ring protein1 ( IbCHYR1 ) gene that encode an E3 ubiquitin ligase linked to root rot resistance. In susceptible varieties, the high dosage allele Pro :: IbCHYR1 Hap1 leads to increased expression of IbCHYR1 . Overexpression of IbCHYR1 increases susceptibility to root rot and Fusarium wilt. IbCHYR1 interacts with the I. batatas CCCH-type zinc-finger protein ( IbZnFR ) to promote its degradation. IbZnFR confers resistance to root rot and Fusarium wilt and improves yield by more than 10%. The high dosage Pro :: IbZnFR Hap2 allele is associated with resistance to root rot disease. Moreover, FfRlpA2 , a conserved Fusarium effector, is identified as a protease inhibitor that stabilizes and hijacks IbCHYR1 to degrade IbZnFR , thereby inhibiting multiple defense pathways. These findings provide insights into Fusarium pathogenicity and a genetic basis for root rot research and improvement of disease-resistant sweet potato varieties.}, archive = {J_ADVS}, author = {Huan Zhang and Zhuoru Dai and Xiaochen Zhang and Meiqi Shang and Xiaoru Gao and Ruiqi Ma and Limeng Zhao and Xiaoli Zhang and Qingchang Liu and Hong Zhai and Shaopei Gao and Ning Zhao and Qinghe Cao and Qiang Li and Shaozhen He}, doi = {10.1002/advs.202415202}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e15202}, shortjournal = {Adv. Sci.}, title = {Natural allelic variations in IbCHYR1–IbZnFR complex regulate fusarium root rot resistance in sweet potato}, volume = {12}, year = {2025}, }
• (2025). The non-coding regulatory variant rs2863002 at chr11p11.2 increases neuroblastoma risk by affecting HSD17B12 expression and lipid metabolism. ADVS, 12(33), e15181. (www)

  @article{ , abstract = {A Genome-wide association study (GWAS) on a European-American cohort identified chr11p11.2 as a neuroblastoma predisposition locus. Combining in-house and public genomic data from neuroblastoma cell lines, this work implicates rs2863002 as the candidate causal variant at the 11p11.2 locus, confirming its cis-regulatory activity through a luciferase reporter assay. The genetic association of rs2863002 with neuroblastoma risk is validated in an Italian case-control cohort. Using ChIP-qPCR, Hi-C, and CRISPR genome editing, this work deciphers the regulatory mechanisms at the risk locus, demonstrating that the rs2863002-C risk allele regulates HSD17B12 expression and reduces GATA3 binding affinity. In vitro functional assays and targeted lipidomic analyses reveal the involvement of the rs2863002-C risk allele in tumorigenicity and modulation of lipid metabolism in neuroblastoma cells through HSD17B12 regulation. This study provides new insights into the genetic basis of neuroblastoma and underscores the importance of post-GWAS functional characterization of risk loci in uncovering relevant biological findings for understanding complex diseases.}, archive = {J_ADVS}, author = {Teresa Maiorino and Marianna Avitabile and Vincenzo Aievola and Annalaura Montella and Vito A. Lasorsa and Ferdinando Bonfiglio and Mariagrazia Cantalupo and Sueva Cantalupo and Gilda Estinto and Matilde Tirelli and Martina Morini and Martina Ardito and Alessandra Eva and Vincenza Cerbone and Lucia Mauriello and Marianna Caterino and Margherita Ruoppolo and John M. Maris and Sharon J. Diskin and Achille Iolascon and Mario Capasso}, doi = {10.1002/advs.202415181}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e15181}, shortjournal = {Adv. Sci.}, title = {The non-coding regulatory variant rs2863002 at chr11p11.2 increases neuroblastoma risk by affecting HSD17B12 expression and lipid metabolism}, volume = {12}, year = {2025}, }
• (2025). Multimodal investigation of angiogenesis and its prevention by small compounds in a zebrafish cancer model. ADVS, 12(33), e15176. (www)

  @article{ , abstract = {Aberrant angiogenesis is a hallmark of many pathologies. In cancer, tumor growth and metastasis strongly depend on angiogenesis triggered by neoplastic cells. Antiangiogenic therapies are approved to treat different kinds of cancer. However, the success of these treatments is so far limited as some patients do not respond at all and others develop resistances. Thus, a deeper understanding of the mechanisms driving tumor angiogenesis and the variations in tumor vessels is crucial. Optical coherence tomography angiography (OCTA) is a fast volumetric imaging technique that provides detailed insights into tumor vascularization and perfusion of vessels in a label-free and non-invasive manner. An ultra-high resolution OCTA and confocal fluorescence imaging pipeline are developed to analyze tumor vascularization and blood perfusion in vivo, using a zebrafish cancer model. OCTA imaging operating at 800 nm is optimized to show slow blood flow allowing to compare the functionality of blood vessels in healthy and tumor-bearing zebrafish. Furthermore, effects of small compounds on tumor vascularization can be investigated with our setup. The key outcomes include a qualitative assessment of vascularization and blood vessel perfusion, along with a quantitative analysis of vessel structure, to evaluate how effective the drugs were at different concentrations.}, archive = {J_ADVS}, author = {Marco Andreana and Ryan Sentosa and Caterina Sturtzel and Martin Pfister and René Werkmeister and Anna Schmitt and David Traver and Rainer Leitgeb and Wolfgang Drexler and Martin Distel and Angelika Unterhuber}, doi = {10.1002/advs.202415176}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e15176}, shortjournal = {Adv. Sci.}, title = {Multimodal investigation of angiogenesis and its prevention by small compounds in a zebrafish cancer model}, volume = {12}, year = {2025}, }
• (2025). Pressure-induced ultralow critical micelle concentration of surfactant for encapsulating dye. ADVS, 12(33), e15151. (www)

  @article{ , abstract = {Achieving the ultralow critical micelle concentration (CMC) of the surfactant encapsulating the dye has spawned a vital pathway to boost the efficiency and stability of dye-sensitized solar cells (DSSCs). The attainment of ultralow CMC while sustaining the constant micelle presents a significant challenge. Here, by an ingenious pressurizing strategy, the ultralow CMC is obtained for the immobilized micelle. The ultralow CMC of cetyl trimethyl ammonium bromide (CTAB) is performed under pressure by the detection of encapsulated coumarin 35 (C35) attractively. At 0.80 GPa, the CMC of CTAB is decreased ≈111-fold to 8.3 ± 0.1 µ m compared to 917.2 ± 8.7 µ m at 0.10 MPa. The ultralow CMC under pressure is probed relying on the quenched fluorescence background of C35. Femtosecond transient absorption spectra confer a clear picture that the pressure-induced fluorescence quenching is ascribed to the reinforced competition for the twisted intramolecular charge transfer process of the C35. This study provides a robust strategy for achieving ultralow CMC, laying the groundwork for the efficient application of DSSCs.}, archive = {J_ADVS}, author = {Qi Li and Xinze Liu and Peng Zhu and Meilin Guo and Guangxiong Hu and Jianbo Gao and Cailong Liu and Ying Shi}, doi = {10.1002/advs.202415151}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e15151}, shortjournal = {Adv. Sci.}, title = {Pressure-induced ultralow critical micelle concentration of surfactant for encapsulating dye}, volume = {12}, year = {2025}, }
• (2025). H3K36me3-guided m6A modification of oncogenic L1CAM-AS1 drives macrophage polarization and immunotherapy resistance in hepatocellular carcinoma. ADVS, 12(33), e14909. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) is one of the most lethal malignancies and epigenetic modifiers play a key role in HCC progression. Histone H3 trimethylation at lysine-36 (H3K36me3) determines deposition of mRNA de novo N 6 -methyladenosine (m 6 A) modification. However, it remains largely elusive how long noncoding RNAs (lncRNAs) are selected for proper m 6 A methylation. The current study provides evidence for L1CAM-AS1 as a novel H3K36me3-guided, m 6 A-modified lncRNA through integration of genome-wide H3K36me3 profiles and transcriptome-wide m 6 A profiles of HCC cells. The crucial m 6 A-modification site in L1CAM-AS1 exon 3 is recognized by IGF2BP1, leading to increased lncRNA stability. Oncogenic L1CAM-AS1 shows higher expression in HCC tissues than in normal specimens, and its elevated expression is associated with shorten patient survival. Mechanistically, L1CAM-AS1 interrupts binding of RAN to the E3 ligase OSTM1, suppresses RAN ubiquitination at Lys152 and Lys167, stabilizes RAN protein, enhances nuclear import of RELA (p65), and activates the NF-κB signaling, leading to up-regulated CCL2 expression. L1CAM-AS1-induced CCL2 secretion from HCC cells enhances M2 polarization of tumor-associated macrophages (TAMs). Meanwhile, immunosuppressive M2 macrophages-released CCL5 augments RELA nuclear import in HCC cells, which in turn activates the NF-κB signaling. Given the critical role of macrophages in anti-tumor immunity, inhibition of the L1CAM-AS1-RAN axis promotes the efficacy of PD-1 blockade via TAM reprogramming in HCC mouse models. In conclusion, this study provides novel insights into how epigenetic alternations are involved in antitumor immunity modulation and illustrates promising potentials of L1CAM-AS1 in immune-checkpoint inhibitor treatments for HCC.}, archive = {J_ADVS}, author = {Teng Wang and Linyu Han and Yanfei Huo and Long Zhang and Yizhou Huang and Nasha Zhang and Ming Yang}, doi = {10.1002/advs.202414909}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e14909}, shortjournal = {Adv. Sci.}, title = {H3K36me3-guided m6A modification of oncogenic L1CAM-AS1 drives macrophage polarization and immunotherapy resistance in hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Soft bioelectronic interfaces for continuous peripheral neural signal recording and robust cross-subject decoding. ADVS, 12(33), e14732. (www)

  @article{ , abstract = {Accurate decoding of peripheral nerve signals is essential for advancing neuroscience research, developing therapeutics for neurological disorders, and creating reliable human–machine interfaces. However, the poor mechanical compliance of conventional metal electrodes and limited generalization of existing decoding models have significantly hindered progress in understanding peripheral nerve function. This study introduces low-impedance, soft-conducting polymer electrodes capable of forming stable, intimate contacts with peripheral nerve tissues, allowing for continuous and reliable recording of neural activity in awake animals. Using this unique dataset of neurophysiological signals, a neural network model that integrates both handcrafted and deep learning-derived features, while incorporating parameter-sharing and adaptation training strategies, is developed. This approach significantly improves the generalizability of the decoding model across subjects, reducing the reliance on extensive training data. The findings not only deepen the understanding of peripheral nerve function but also open avenues for developing advanced interventions to augment and restore neurological functions.}, archive = {J_ADVS}, author = {Liangpeng Chen and Yang Liu and Yewei Huang and Ziyang Li and Chao Zhang and Jun Tang and Xueyuan Ling and Bowen Cao and Baowang Li and Yuan Zhang and Wenjianlong Zhou and Qin Xu and Shunchang Ma and Xiudong Guan and Dan Xiao and Jingyao Geng and Yutong Zhao and Guolin Li and Yi-xuan Wang and Wang Jia and Yuanwen Jiang and Milin Zhang and Deling Li}, doi = {10.1002/advs.202414732}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e14732}, shortjournal = {Adv. Sci.}, title = {Soft bioelectronic interfaces for continuous peripheral neural signal recording and robust cross-subject decoding}, volume = {12}, year = {2025}, }
• (2025). Dual-working-pattern nanosheet-based hydrogel sensors for constructing human-machine and physiological-electric interfaces. ADVS, 12(33), e14301. (www)

  @article{ , abstract = {While hydrogels are ideal building blocks for fabricating next-generation epidermal electronics to acquire high-fidelity electrical signals induced by motion and physiological activities, an unresolved issue remains: the differentiation and selection of sensing modes in hydrogel sensors. The novel design leverages numerous conductive nanosheets, randomly arranged in a series-parallel configuration, embedded within a highly compliant dielectric hydrogel. For the nanosheets, poly(3,4-ethylenedioxythiophene) (PEDOT) is deposited on the surface of sulfonated cellulose nanosheets (SCNS) to function as microelectrodes (PEDOT@SCNS). The resulting nanosheet-based hydrogel (NSH) demonstrates remarkable stretchability (1356%), excellent adaptability (storage modulus of 102 Pa), and self-adhesiveness (21.7 kPa on pigskin). The nanosheet microelectrodes enable the formation of both microcapacitor arrays and conductive paths within the ultrasoft hydrogel, facilitating the construction of high-fidelity capacitive sensors and bioelectrodes for the real-time monitoring and classification of human activities and physiological states, respectively. This NSH, which significantly reduces skin-interfacial impedance, has demonstrated strong potential as candidate sensors for advanced applications in EMG, facial nerve monitoring, ECG, and brain activity monitoring, achieving reduced RMS noise (9.7 µV) and minimal motion artifacts.}, archive = {J_ADVS}, author = {Shitao Shi and Yuanyuan Wang and Zewei Ye and Hongxia Xie and Chencong Liu and Jiaqi Liao and Dawei Zhao and Qingfeng Sun and Julia L. Shamshina and Xiaoping Shen}, doi = {10.1002/advs.202414301}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e14301}, shortjournal = {Adv. Sci.}, title = {Dual-working-pattern nanosheet-based hydrogel sensors for constructing human-machine and physiological-electric interfaces}, volume = {12}, year = {2025}, }
• (2025). Tumor-associated sympathetic nerves promote the progression of epstein-barr virus-positive diffuse large B-cell lymphoma. ADVS, 12(33), e13580. (www)

  @article{ , abstract = {Epstein-Barr virus-positive (EBV + ) diffuse large B-cell lymphoma (DLBCL) exhibits a poorer prognosis with limited treatment options. Although recent evidence indicates that the peripheral nervous system is associated with tumor progression, its role in EBV + DLBCL remains poorly understood. In the cohort, patients with EBV⁺DLBCL exhibit significantly shorter overall survival (OS). Two EBV + DLBCL cell lines are established and characterized. Although cell proliferation does not differ significantly in vitro, tumors derived from EBV + DLBCL cells demonstrate accelerated growth compared to their parental counterparts in mouse models. Mechanistically, transcriptome analysis reveals the upregulation of axonogenesis-related genes and pathways in EBV + DLBCL tumors. Immunostaining confirms increased nerve fiber infiltration in SUDHL6-EBV xenografts and enhance neurite outgrowth from dorsal root ganglia co-cultured with EBV + DLBCL cells. Both in vitro and in vivo experiments show that sympathetic nerves promote tumor growth via β2-adrenergic receptors (β2ARs), which are attenuated by selective β2AR blockers. Clinically, EBV⁺DLBCL patient samples show more sympathetic nerve fibers and higher β2AR expression, both of which are associated with poorer survival. Furthermore, a meta-analysis suggests that beta-blocker use is linked to a reduced risk of cancer-specific mortality. Together, these findings suggest that sympathetic nerve innervation drives the progression of EBV + DLBCL via β2ARs, highlighting a potential therapeutic target.}, archive = {J_ADVS}, author = {Silan Huang and Dexin Lei and Linbin Yang and Aiwei Bi and Yanlou Wang and Peng Zhang and Dongyu Zhuang and Honglian Liu and Qingqing Cai and Man Nie and Yi Xia}, doi = {10.1002/advs.202413580}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e13580}, shortjournal = {Adv. Sci.}, title = {Tumor-associated sympathetic nerves promote the progression of epstein-barr virus-positive diffuse large B-cell lymphoma}, volume = {12}, year = {2025}, }
• (2025). Corrigendum to ““Cicada out of the shell” deep penetration and blockage of the HSP90 pathway by ROS-responsive supramolecular gels to augment trimodal synergistic therapy”. ADVS, 12(33), e12868. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202512868}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e12868}, shortjournal = {Adv. Sci.}, title = {Corrigendum to ““Cicada out of the shell” deep penetration and blockage of the HSP90 pathway by ROS-responsive supramolecular gels to augment trimodal synergistic therapy”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Multicomponent transition metal dichalcogenide nanosheets for imaging-guided photothermal and chemodynamic therapy”. ADVS, 12(33), e12650. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202512650}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e12650}, shortjournal = {Adv. Sci.}, title = {Correction to “Multicomponent transition metal dichalcogenide nanosheets for imaging-guided photothermal and chemodynamic therapy”}, volume = {12}, year = {2025}, }
• (2025). Correction to “hESCs-derived organoids achieve liver zonation features through LSEC modulation”. ADVS, 12(33), e11802. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202511802}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e11802}, shortjournal = {Adv. Sci.}, title = {Correction to “hESCs-derived organoids achieve liver zonation features through LSEC modulation”}, volume = {12}, year = {2025}, }
• (2025). Development and validation of machine learning-based marker for early detection and prognosis stratification of nonalcoholic fatty liver disease. ADVS, 12(33), e10527. (www)

  @article{ , abstract = {Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease and is considered the hepatic manifestation of metabolic syndrome, triggering out adverse outcomes. A stacked multimodal machine learning model is constructed and validated for early identification and prognosis stratification of NAFLD by integrating genetic and clinical data sourced from 36 490 UK Biobank and 9 007 Nanfang Hospital participants and extracted its probabilities as in-silico scores for NAFLD (ISNLD). The efficacy of ISNLD is evaluated for the early prediction of severe liver disease (SeLD) and analyzed its association with metabolism-related outcomes. The multimodal model performs satisfactorily in classifying individuals into low- and high-risk groups for NAFLD, achieving area under curves (AUCs) of 0.843, 0.840, and 0.872 within training, internal, and external test sets, respectively. Among high-risk group, ISNLD is significantly associated with intrahepatic and metabolism-related complications after lifestyle factors adjustment. Further, ISNLD demonstrates notable capability for early prediction of SeLD and further stratifies high-risk subjects into three risk subgroups of elevated risk for adverse outcomes. The findings emphasize the model's ability to integrate multimodal features to generate ISNLD, enabling early detection and prognostic prediction of NAFLD. This facilitates personalized stratification for NAFLD and metabolism-related outcomes based on digital non-invasive markers, enabling preventive interventions.}, archive = {J_ADVS}, author = {Lushan Xiao and Lin Zeng and Jiaren Wang and Chang Hong and Ziyong Zhang and Chengkai Wu and Hao Cui and Yan Li and Ruining Li and Shengxing Liang and Qijie Deng and Wenyuan Li and Xuejing Zou and Pengcheng Ma and Li Liu}, doi = {10.1002/advs.202410527}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e10527}, shortjournal = {Adv. Sci.}, title = {Development and validation of machine learning-based marker for early detection and prognosis stratification of nonalcoholic fatty liver disease}, volume = {12}, year = {2025}, }
• (2025). Correction to “Tandem-mass-tag based proteomic analysis facilitates analyzing critical factors of porous silicon nanoparticles in determining their biological responses under diseased condition”. ADVS, 12(33), e09004. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202509004}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e09004}, shortjournal = {Adv. Sci.}, title = {Correction to “Tandem-mass-tag based proteomic analysis facilitates analyzing critical factors of porous silicon nanoparticles in determining their biological responses under diseased condition”}, volume = {12}, year = {2025}, }
• (2025). Engineering of multi-dynamic bonds toward room-temperature self-healing Epoxy/MXene adaptable network with record-high toughness. ADVS, 12(33), e08780. (www)

  @article{ , abstract = {Epoxy thermosets with exceptional toughness and self-healing properties are essential for high-end manufacturing applications and sustainable development. Conventional epoxy-crosslinked networks are inherently brittle, leading to a lack of these traits. Drawing inspiration from mussel nacre and byssus, a bionic epoxy/MXene network is developed, featuring a multi-type dynamic bond system and an inverse-artificial nacre structure. Through hierarchical assembly, the network integrates side-chain quadruple hydrogen bonds (H-bonds), dynamic disulfide bonds, and interfacial H-bonds, facilitating rapid energy dissipation. This epoxy demonstrates exceptional performance through meticulous engineering, exhibiting impressive toughness (210.75 MJ m −3 ), exceeding that of spider silk by 30%. It also shows remarkable stretchability (864.72%) and rapid self-healing capabilities (90.0% recovery within 2 h at 25 °C). This combination of these properties is consistently maintained under various environmental conditions due to the protection of the dynamic bonds by the hydrophobic chains. Furthermore, the bionic network enhanced the composites with superior gas impermeability and high interfacial adhesive strength (9.58 MPa). This study offers novel insights into the development of high-performance, durable protective coatings, and flexible devices designed for enhanced tolerance to harsh marine environments.}, archive = {J_ADVS}, author = {Xiaobo Zhu and Yu Hao and Liang-Feng Huang and Haichao Zhao and Liping Wang}, doi = {10.1002/advs.202508780}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e08780}, shortjournal = {Adv. Sci.}, title = {Engineering of multi-dynamic bonds toward room-temperature self-healing Epoxy/MXene adaptable network with record-high toughness}, volume = {12}, year = {2025}, }
• (2025). Hyperspectral imaging techniques for lyophilization: Advances in data-driven modeling strategies and applications. ADVS, 12(33), e08506. (www)

  @article{ , abstract = {Lyophilization, aka freeze drying, is a key process used in the production of biotherapeutic products. The optimization of lyophilization formulations and operations is a slow process that could be accelerated by on-line analytics. In recent years, hyperspectral imaging (HSI) has garnered increasing attention from both academia and industry in biopharmaceutical and food engineering fields. As a non-invasive, rapid, non-destructive, accurate, and automated tool that combines advantages from both spectroscopy and imaging techniques, HSI holds significant potential for analyzing and optimizing lyophilization processes and products. However, the huge and information-rich datasets generated from HSI are difficult to be modeled and interpreted properly. This article reviews and discusses the literature on the application of HSI on lyophilization, and the strategies that use the resulting data to build models. Such strategies include preprocessing, spectral unmixing, classification and regression, and data fusion. From the data modeling and application perspectives, the current challenges and future prospects regarding HSI techniques for lyophilization are addressed. This article is intended to provide guidance and insights for non-specialist researchers and engineers into leveraging HSI and the data-driven modeling strategies for addressing a wide range of lyophilization-related challenges.}, archive = {J_ADVS}, author = {Huiwen Yu and Prakitr Srisuma and Cedric Devos and Jie Wang and Allan S. Myerson and Richard D. Braatz}, doi = {10.1002/advs.202508506}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e08506}, shortjournal = {Adv. Sci.}, title = {Hyperspectral imaging techniques for lyophilization: Advances in data-driven modeling strategies and applications}, volume = {12}, year = {2025}, }
• (2025). Exploring AAV-mediated gene therapy for inner ear diseases: From preclinical success to clinical potential. ADVS, 12(33), e08397. (www)

  @article{ , abstract = {Hearing loss imposes a significant global health burden and often results from genetic factors and various external influences, such as noise exposure and the use of ototoxic drugs. Recent advancements in adeno-associated virus (AAV)-mediated gene therapy offer promising new avenues for the treatment of inner ear diseases. Clinical trials of AAV-mediated gene therapies show impressive preliminary results, although further research is needed to evaluate the safety and long-term effects of these therapies. Preclinical AAV-mediated gene therapy is notable for its high transduction efficiency and safety. In this article, the development of AAV-mediated gene therapies is reviewed for inner ear diseases, categorizing these therapies by their strategies for treating hereditary hearing loss, including gene replacement and cluster regularly interspaced short palindromic repeat-based methods. AAV-mediated hair cell regeneration therapy is also reviewed for acquired hearing loss, as well as methods to prevent acquired hearing loss. In this article, it is hoped to provide a comprehensive overview of recent progress in AAV-mediated gene therapy and its future potential, thereby highlighting the importance of this therapy for researchers and clinicians in the field.}, archive = {J_ADVS}, author = {Fan Wu and Wuhui He and Yun Xiao and Qiong Wu and Qing Zhang and Tiesong Zhang and Lei Xu and Xinyi Pang}, doi = {10.1002/advs.202408397}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e08397}, shortjournal = {Adv. Sci.}, title = {Exploring AAV-mediated gene therapy for inner ear diseases: From preclinical success to clinical potential}, volume = {12}, year = {2025}, }
• (2025). Cu─X bonds regulated conduction and polarization loss in conductive metal-organic framework under electromagnetic field. ADVS, 12(33), e08379. (www)

  @article{ , abstract = {Conduction and polarization are known to profoundly impact conductive metal–organic frameworks (c-MOFs) for their applications in electromagnetic wave (EMW) absorption. Albeit a few advances along c-MOF platforms in enhancing their EMW absorption performances, reticular modulation-led inter/intra-layer conduction and polarization loss remains an unmet challenge. To address this, a ligand substitution-guided bottom-up structural control strategy is introduced to study the depth of reticular modulation-led inter/intra-layer conduction and polarization loss in c-MOFs under an electromagnetic (EM) field. A family of triphenylene-X ligands (X = −NH 2 , −OH, and −SH) is harnessed to afford an isoreticular family of three Cu-based c-MOFs. Thanks to the distinct Cu─X bonds, such a platform allowed to systematically study the synergistic features of conduction and polarization loss in EMW absorption enhancement. One of the trio, Cu 3 (HITP) 2 (X = −NH 2 ; HITP, 2,3,6,7,10,11-hexahydroxytriphenylene) is identified with an optimal EM loss capacity under the EM field, achieving a record-high reflection loss of −63.03 dB in the effective absorption range of 3–18 GHz band. Setting up a new benchmark for EM loss among c-MOFs, this study introduces a way to leverage control in the charge mobility characteristics of Cu─X bonds relative to the dielectric losses at both molecular and atomic scales.}, archive = {J_ADVS}, author = {Siyao Cheng and Qinglin Zhou and Daohu Sheng and Wei Dong and Jinhu Dou and Yuanbiao Huang and Rong Cao and Aming Xie and Roland A. Fischer and Soumya Mukherjee and Weijin Li}, doi = {10.1002/advs.202508379}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e08379}, shortjournal = {Adv. Sci.}, title = {Cu─X bonds regulated conduction and polarization loss in conductive metal-organic framework under electromagnetic field}, volume = {12}, year = {2025}, }
• (2025). Zinc alleviates gut barrier dysfunction by promoting the methylation of AKT. ADVS, 12(33), e08280. (www)

  @article{ , abstract = {Zinc plays a crucial role in the gut barrier function and are widely used for the prevention of bowel disease. However, the mechanism via which zinc supplementation exerts this regulatory effect is unclear. The present study identifies and characterizes the zinc-responsive activation of AKT and demonstrates its function in alleviating gut barrier dysfunction. Mechanistically, zinc increased intracellular SAM production, a methyl donor, by promoting the activation of the metallochaperone ZNG1-METAP1 complex. Subsequently, zinc facilitates methylation (symmetrical dimethylarginine, SDMA) of AKT at residues R391 and R15, which is facilitated by PRMT5. The AKT SDMA modification promotes AKT translocation from the cytoplasm to the plasma membrane and its interaction with mTORC2, ultimately promoting AKT activation and cell proliferation. Notably, histidine has an antagonistic effect on zinc-induced the AKT activation, cell proliferation, and gut barrier improvement by chelating zinc. These results demonstrate that zinc activates AKT and alleviates gut barrier dysfunction by inducing activation of the ZNG1-METAP1-PRMT5-AKT SDMA pathway, and highlight that limiting histidine intake may have effective therapeutic potential for bowel diseases such as Crohn's disease and Ulcerative colitis.}, archive = {J_ADVS}, author = {Chuanjiang Cai and Yining Zheng and Bo Sun and Guoyan Wang and Pengfei Li and Huijun Geng and Rongnuo Li and Miaomiao Zhu and Yuanyuan Zhu and Dingping Feng and Lei Chen and Guiyan Chu and Lu Deng and Shiyan Qiao}, doi = {10.1002/advs.202508280}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e08280}, shortjournal = {Adv. Sci.}, title = {Zinc alleviates gut barrier dysfunction by promoting the methylation of AKT}, volume = {12}, year = {2025}, }
• (2025). Advanced brain-on-a-chip for wetware computing: A review. ADVS, 12(33), e08120. (www)

  @article{ , abstract = {In pursuit of low-power consumption and surpassing computational limitations of silicon-based chips, people are beginning to seek more efficient computing devices, such as Wetware Computing. The cutting-edge approach uses living biological tissues, specifically neuronal networks, to perform computational tasks. This computing method, which is a mixture of hardware, software, and biology, is an emerging computing method that has received a lot of attention in recent years. As an important branch of organ-on-a-chip, brain-on-a-chip, which combines Micro-Electro-Mechanical System technology, electronic technology, and tissue engineering, can provide a powerful research platform for Wetware Computing. In this paper, the brain-on-a-chip for Wetware Computing is reviewed. This paper summarizes the methods for establishing a brain-on-a-chip for Wetware Computing, including the brain organoids cultured in vitro, microelectrode arrays, electrophysiology interfaces, and microfluidic platforms that make up the brain-on-a-chip. In addition, the data processing methods of brain-on-a-chip are reviewed, including encoding and decoding methods. In this paper, the focus is also on the application and the prospect of brain-on-a-chip in Wetware Computing.}, archive = {J_ADVS}, author = {Shangchen Li and Yaoyao Liu and Sihan Hua and Yu Wang and Shutong Sun and Longhui Jiang and Chengji Lu and Juntao Liu and Huaizhang Shi and Pei Wu and Xinxia Cai and Jinping Luo}, doi = {10.1002/advs.202508120}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e08120}, shortjournal = {Adv. Sci.}, title = {Advanced brain-on-a-chip for wetware computing: A review}, volume = {12}, year = {2025}, }
• (2025). CXCL13 expression promotes CAR t cell antitumor activity and potentiates response to PD-1 blockade. ADVS, 12(33), e08095. (www)

  @article{ , abstract = {Immune checkpoint blockade (ICB) and chimeric antigen receptor (CAR) T cell therapies have revolutionized cancer immunotherapy, offering significant benefits across various cancers. However, challenges remain, particularly in solid tumors where immunosuppressive tumor microenvironments and T cell exhaustion limit effectiveness. Combining ICB with CAR T cell therapy has shown potential but requires further optimization for effective synergy. Here, the bioinformatic analysis identified that CXCL13 expression is highly elevated in T cells from patients who respond to ICB, indicating its possible role in enhancing T cell antitumor responses. Mouse CAR T cells are engineered to overexpress CXCL13 and observed that these cells displayed reduced exhaustion, increased central memory phenotype, and improved mitochondrial function and proliferation in an AKT-mTOR dependent manner. CXCL13-overexpressing CAR T cells show significantly increased antitumor activity in vivo, particularly when combined with PD-1 inhibition, promoting the expansion and persistence of early exhausted CD8 + CAR T cells. CXCL13 also conferred similar in vitro phenotypic enhancements in human CAR T cells as observed in murine cells. These results indicate that CXCL13 expression improves CAR T cell function and responsiveness to ICB, offering a promising and translationally relevant strategy to optimize CAR T cell therapy for solid tumors in clinical settings.}, archive = {J_ADVS}, author = {Yang Zhou and Wenli Zhao and Yihan Zhu and Hongyan Liu and Yicheng Sun and Zhengrong Gong and Xuanyi Li and Ziying Liu and Kang Wen and Yicheng Wang and Jie Ren and Ruipei Xiao and Ling Jiang and Yanfeng Hu and Enguang Bi and Xiaoyong Zhang}, doi = {10.1002/advs.202508095}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e08095}, shortjournal = {Adv. Sci.}, title = {CXCL13 expression promotes CAR t cell antitumor activity and potentiates response to PD-1 blockade}, volume = {12}, year = {2025}, }
• (2025). Nature-inspired nanostructures from multiple-species biomembranes: Rational engineering and therapeutic applications in tumor-targeted nanomedicine. ADVS, 12(33), e07952. (www)

  @article{ , abstract = {The advent of nanomedicine is profoundly revolutionizing conventional paradigms in cancer therapeutics. Selected formulations encompassing lipid nanoparticles and polymeric nanoparticles have already attained regulatory approval for clinical treatment. Nonetheless, achieving precise spatiotemporal control of exogenous nanomedicine within intricate physiological environments remains a formidable challenge. Drawing inspiration from evolutionarily optimized natural biological architectures, the development of biomembrane-derived nanostructures with unique biological activities provides a new impetus for designing personalized antitumor drugs. Biomembrane-derived constituents, particularly cell membrane, extracellular vesicles, and other bioactive payloads, have inherited their precise targeting, specific tumor killing, and dynamic tumor immunosuppressive microenvironments remodeling properties in antitumor intervention. Here, the diverse biomembrane engineering strategies to equip the biomembrane with plentiful functionalities are highlighted. Moreover, the cutting-edge innovations of mammalian cells/bacteria/plants-derived biomembrane nanostructures and their applications for advancing cancer nanomedicine development are systematically reviewed. Finally, the current challenges and future opportunities are proposed to realize the whole potential of biomembrane nanomedicine toward clinical transformation.}, archive = {J_ADVS}, author = {Xiaodan Wei and Chi Wang and Xiangyan Chen and Yuanyuan Zhu and Mei Yang and Ningxi Li and Honglin Huang and Guangjian Zhang and Mingzhen Zhang and Yiyao Liu and Rui Gao}, doi = {10.1002/advs.202507952}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07952}, shortjournal = {Adv. Sci.}, title = {Nature-inspired nanostructures from multiple-species biomembranes: Rational engineering and therapeutic applications in tumor-targeted nanomedicine}, volume = {12}, year = {2025}, }
• (2025). H2O2 production via artificial photosynthesis over defective graphitic carbon nitride. ADVS, 12(33), e07913. (www)

  @article{ , abstract = {Metal-free graphitic carbon nitride has been considered as a promising candidate for hydrogen peroxide (H 2 O 2 ) photosynthesis, with the advantage of low-cost, high stability, and environmentally friendly capacity. However, such a solar-to-chemical conversion still suffers from limited light utilization, confined surface adsorption, and restricted reduction/oxidation reaction pathway. At this juncture, this bottleneck has been overcome through diverse modifications over carbon nitride, such as defect engineering graphitic carbon nitride with modulated physical and chemical properties, which performs satisfactory visible-light absorption, sufficient active sites, and promotes charge transfer kinetics for artificial solar-to-chemical conversion. In this review, the recent advances for H 2 O 2 photosynthesis over defective graphitic carbon nitride are described, including the existing principles for H 2 O 2 formation, the factors affecting photosynthesis, the fabrication strategies toward novel materials, and the detailed pathways for H 2 O 2 formation. The functions of defects, the properties of materials, and the reaction mechanisms, and the selectivity, as well as in situ characterizations for catalyst synthesis and pathway exploration, have been summarized clearly. Finally, the advantages and shortcomings, together with the challenges and prospects, are highlighted for the development of defect engineering over carbon nitride for H 2 O 2 photosynthesis.}, archive = {J_ADVS}, author = {Yiwen Zhang and Dingle Wu and Xiaofei Zeng and Bocheng Qiu and Qiaohong Zhu and Jinlong Zhang}, doi = {10.1002/advs.202507913}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07913}, shortjournal = {Adv. Sci.}, title = {H2O2 production via artificial photosynthesis over defective graphitic carbon nitride}, volume = {12}, year = {2025}, }
• (2025). Boosting photovoltaic respond through molecular engineering in organic manganese (II) bromide for high-sensitivity X‑Ray detection. ADVS, 12(33), e07896. (www)

  @article{ , abstract = {Zero-dimensinoal (0D) manganese-based metal halides (MHs) demonstrate excellent structural tunable through organic cation design, enabling precise control of Mn─Mn distances to modulate critical photoelectric physical properties. Here, two novel 0D PTA 2 MnBr 4 (PTA = phenyltrimethylammonium) are synthesized and DMA 2 MnBr 4 (DMA = dimethylammonium) wafer with a manipulation of octahedra are synthesized by a precise molecular design. Structural analysis reveals that the PTA-functional group with extended π -conjugation lengths increases the Mn─Mn distance, results in a lower energy transfer and reduced exciton binding energy compared to DMA⁺ (linear carbon chain). Consequently, PTA 2 MnBr 4 demonstrates an enhanced photoluminescence quantum yield and prolonged exciton lifetime. The engineered X-ray detector based on PTA 2 MnBr 4 wafer exhibits a higher sensitivity of 1122 µC Gy air −1 cm −2 and a lower detection limit of 95 nGy air s −1 , while DMA 2 MnBr 4 device are 708.2 µC Gy air −1 cm −2 and 180 nGy air s −1 , respectively, which paves the way for high-efficiency photoelectronic applications. This suggests that molecular engineering is a robust approach for designing high-performance 0D manganese halides for radiation detection.}, archive = {J_ADVS}, author = {Feifei Chai and Youkui Xu and Lanlan Li and Guoqiang Peng and Hengxin Li and Guiqiang Li and Dongdong Li and Qian Wang and Zhun Yao}, doi = {10.1002/advs.202507896}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07896}, shortjournal = {Adv. Sci.}, title = {Boosting photovoltaic respond through molecular engineering in organic manganese (II) bromide for high-sensitivity X‑Ray detection}, volume = {12}, year = {2025}, }
• (2025). LncRNA TMEM99 complexes with IGF2BP2 to inhibit autophagy in lung adenocarcinoma. ADVS, 12(33), e07871. (www)

  @article{ , abstract = {Lung adenocarcinoma (LUAD), the most common type of lung cancer, has a poor prognosis. Long noncoding RNAs (lncRNAs) play a key role in LUAD progression, yet the biological role of lncRNA TMEM99 remains unexplored. In this study, its function in inhibiting autophagy in LUAD is explored. Using RNA sequencing and quantitative reverse transcription PCR (qRT-PCR), TMEM99 is found upregulated in LUAD tissues and cell lines, correlating with poor patient outcomes. In vivo and in vitro assays confirmed that TMEM99 promotes cell proliferation, migration, and invasion, and inhibits autophagy. Mechanistically, the 3′ end of TMEM99 binds to the K‑homology domain 1 (KH1) and KH4 domains of far upstream element‑binding protein 3 (FUBP3), stabilizing its protein. The TMEM99-FUBP3 complex binds to p21 mRNA and recruits IGF2BP2 in an N⁶‑methyladenosine (m⁶A)-dependent manner, which enhances mRNA stability and translation efficiency. This study reveals that TMEM99 plays a crucial regulatory role in LUAD autophagy and presents a novel cytoplasmic regulatory mechanism contributing to LUAD progression.}, archive = {J_ADVS}, author = {Zhigang Wu and Yue Zhao and Yizhou Peng and Pengcheng Liu and Qixuan Huang and Yang Wo and Yunjian Pan and DongDong Zheng and Chongze Yuan and Yan Shang and Xiao Chen and Hui Hong and Yihua Sun}, doi = {10.1002/advs.202507871}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07871}, shortjournal = {Adv. Sci.}, title = {LncRNA TMEM99 complexes with IGF2BP2 to inhibit autophagy in lung adenocarcinoma}, volume = {12}, year = {2025}, }
• (2025). Protein spatial structure meets artificial intelligence: Revolutionizing drug Synergy–Antagonism in precision medicine. ADVS, 12(33), e07764. (www)

  @article{ , abstract = {Targeted drug design and development, as a core area of modern pharmaceutical research, critically depends on the assessment of protein site druggability as a fundamental component. This review systematically examines the latest research progress and application prospects of drug synergy and antagonism prediction methods that integrate protein three-dimensional spatial structure with artificial intelligence (AI) technologies. This review showcases the molecular biological mechanisms of drug synergism vs antagonism mediated by transcription factors, signal pathway regulation, and membrane transport proteins, and subsequently delves into the molecular structural basis of protein–drug interactions, including precise identification methods for drug binding sites, optimization strategies for molecular docking techniques, and the mechanisms and structural characteristics of multi-target drugs. The review systematically evaluates the practical application progress of AI technologies, especially machine learning and deep learning algorithms, in predicting drug synergy–antagonism effects, as well as the methodological approaches for constructing and evaluating the performance of AI prediction models that integrate multi-source biological data. These research findings provide a solid theoretical foundation for the precision treatment of cancer, infectious diseases, and metabolic disorders, with significant clinical and translational implications for advancing personalized medicine strategies in clinical practice and facilitating the rational design and development of novel multi-target drugs.}, archive = {J_ADVS}, author = {Anqi Lin and Chang Che and Aimin Jiang and Chang Qi and Antonino Glaviano and Zhijie Zhao and Zhirou Zhang and Zaoqu Liu and Ziyao Zhou and Quan Cheng and Shuofeng Yuan and Peng Luo}, doi = {10.1002/advs.202507764}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07764}, shortjournal = {Adv. Sci.}, title = {Protein spatial structure meets artificial intelligence: Revolutionizing drug Synergy–Antagonism in precision medicine}, volume = {12}, year = {2025}, }
• (2025). Bioprinted organoids: An innovative engine in biomedicine. ADVS, 12(33), e07317. (www)

  @article{ , abstract = {Bioprinted organoids integrate bioprinting technology with organoid research, enabling the simultaneous reconstruction of human tissue morphology and physiological function in vitro. This approach offers distinct advantages in organoid fabrication, particularly in terms of structural precision, tissue mimicry, and functional fidelity. By leveraging the complementary strengths of both technologies, bioprinted organoids allow for the fabrication of personalized, architecturally engineered models that more accurately replicate organogenesis, physiological processes, and disease progression. Herein, this review outlines the key advantages of bioprinted organoids, with a focus on their ability to precisely control morphology, dimensions, and spatial organization. Bioprinted organoids are further categorized into three types based on their cellular origins and summarize recent progress in their application for human tissue modeling. Finally, ongoing challenges and future possibilities are sketched out, offering insights for potential innovation and research directions in the field. Bioprinted organoids not only propel the advancement of organoid research but also drive the evolution of bioprinting technologies. This integrated approach represents a powerful synergy between biomanufacturing and clinical medicine to pave the way for a new era in biomedical science and personalized healthcare.}, archive = {J_ADVS}, author = {Zhengwei Li and Kai Li and Cheng Zhang and Yingying Zhao and Yiyuan Guo and Jia He and Shiyuan Chang and Xinyi Fang and Kaizheng Liu and Pingping Zhu and Zhenzhen Chen and Changshun Ruan}, doi = {10.1002/advs.202507317}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07317}, shortjournal = {Adv. Sci.}, title = {Bioprinted organoids: An innovative engine in biomedicine}, volume = {12}, year = {2025}, }
• (2025). Anthocyanins prevent mastitis exacerbation by inhibiting PANoptosis activation. ADVS, 12(33), e07172. (www)

  @article{ , abstract = {Mastitis poses a huge economic burden, with antibiotics treatment leading to drug residues and the emergence of bacterial resistance. Therefore, there is an urgent need to develop alternatives to antibiotics for the treatment of mastitis. Anthocyanins (ACN) have excellent anti-inflammatory properties. However, the key pathways of mastitis disease progression and the therapeutic effects of ACN on mastitis remain poorly understood. In this study, using cows, goats, and mice as animal models, the efficacy of ACN extracts from crabapple fruit is investigated in alleviating the severity of mastitis and blood milk barrier (BMB) damage. A monomeric component, cyanidin 3- O -galactoside (C3Gal) is identified, that exhibited considerable effect on mastitis. Mechanistically, C3Gal regulated mastitis progression by inhibiting PANoptosis activation, and suppressing gasdermin D N-terminal activity to regulate BMB damage during mastitis. These findings establish PANoptosis as a critical pathway in the rapid progression of mastitis and highlight the potential of ACN extracts as effective alternatives to antibiotic for mastitis treatment. This study provides a promising strategy for the discovery and application of drugs for the treatment of inflammatory diseases, expands the application of ACN in inflammatory diseases, and elucidates the molecular mechanisms underlying its anti-inflammatory effect.}, archive = {J_ADVS}, author = {Rui Feng and Lin Guo and Fan Wang and Qian Zhang and Guoyan Wang and Hefei Huang and Wei Du and Hong An and Yue Yang and Henghui Miao and Peng Zheng and Tingting Chu and Dengke Zhang and Xiaoxue Yan and Xiaoyu Mi and Qian Ma and Weilin Gao and Yushan Li and Song Li and Yong Zhang and Zhenliang Zhu and Yu Wang and Jun Liu and Xu Liu}, doi = {10.1002/advs.202507172}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07172}, shortjournal = {Adv. Sci.}, title = {Anthocyanins prevent mastitis exacerbation by inhibiting PANoptosis activation}, volume = {12}, year = {2025}, }
• (2025). Achieving complex nanostructures: The role of hydrogen in controlling mechanical alloying and microstructure evolution in the TiVZrNbHf-cu system. ADVS, 12(33), e07168. (www)

  @article{ , abstract = {Hydrogen is key in reducing greenhouse gas emissions in materials production. At the same time, it significantly affects mechanical properties, often causing unwanted embrittlement. However, rather than solely addressing these disadvantages, hydrogen's inevitable role in sustainable metallurgy should be leveraged to create new and potentially superior materials. Here, it is shown that using hydrogen in the form of metal hydrides introduces a barrier to mechanical alloying, stabilizing otherwise unattainable microstructures. Severe plastic deformation of a composite of the equiatomic high entropy alloy (HEA) TiVZrNbHf and Cu leads to amorphization, while substituting the HEA with its hydride preserves the two-phase structure. Monte Carlo simulations confirm that the significantly different hydrogen affinities, together with the restricted dislocation motion in the hydride, create a barrier to mechanical alloying. This hydride route could enable new microstructure states, even in well-studied material systems. It opens an additional dimension in designing materials containing phases with diverging hydrogen affinities, offering tighter control over mechanical alloying.}, archive = {J_ADVS}, author = {Lukas Schweiger and Florian Spieckermann and Peter Cengeri and Michael Burtscher and Lukas Schretter and Matthias Eichinger and Gregor Mori and Alexander Schökel and Michael Zehetbauer and Erhard Schafler and Daniel Kiener and Jürgen Eckert}, doi = {10.1002/advs.202507168}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07168}, shortjournal = {Adv. Sci.}, title = {Achieving complex nanostructures: The role of hydrogen in controlling mechanical alloying and microstructure evolution in the TiVZrNbHf-cu system}, volume = {12}, year = {2025}, }
• (2025). Programmable DNA-based molecular neural network biocomputing circuits for solving partial differential equations. ADVS, 12(33), e07060. (www)

  @article{ , abstract = {Partial differential equations, essential for modeling dynamic systems, persistently confront computational complexity bottlenecks in high-dimensional problems, yet DNA-based parallel computing architectures, leveraging their discrete mathematics merits, provide transformative potential by harnessing inherent molecular parallelism. This research introduces an augmented matrix-based DNA molecular neural network to achieve molecular-level solving of biological Brusselator PDEs. Two crucial innovations address existing technological constraints: (i) an augmented matrix-based error-feedback DNA molecular neural network, enabling multidimensional parameter integration through DNA strand displacement cascades and iterative weight optimization; (ii) incorporating membrane diffusion theory with division operation principles into DNA circuits to develop partial differential calculation modules. Simulation results demonstrate that the augmented matrix-based DNA neural network efficiently and accurately learns target functions; integrating the proposed partial derivative computation strategy, this architecture solves the biological Brusselator PDE numerically with errors below 0.02 within 12,500 s. This work establishes a novel intelligent non-silicon-based computational framework, providing theoretical foundations and potential implementation paradigms for future bio-inspired computing and unconventional computing devices in life science research.}, archive = {J_ADVS}, author = {Yijun Xiao and Alfonso Rodríguez-Patón and Jianmin Wang and Pan Zheng and Tongmao Ma and Tao Song}, doi = {10.1002/advs.202507060}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e07060}, shortjournal = {Adv. Sci.}, title = {Programmable DNA-based molecular neural network biocomputing circuits for solving partial differential equations}, volume = {12}, year = {2025}, }
• (2025). Humidity-controlled smart window with synchronous solar and thermal radiation regulation. ADVS, 12(33), e06980. (www)

  @article{ , abstract = {Dynamic and continuous regulation of both solar and thermal radiation through windows is critical for enhancing building energy efficiency. However, achieving such adaptive regulations within a single window remains a formidable challenge. In this study, a humidity-responsive polytetrafluoroethylene (PTFE)/ polyvinyl alcohol (PVA) composite membrane is developed with a nanoporous structure and integrated between two layers of glass to engineer a humidity-controlled smart window. By modulating the humidity level between the glass layers, the smart window enables the dynamic and coordinated modulation of solar and thermal radiation via the reversible adsorption and desorption of water vapor by the PTFE/PVA composite. The results indicate that the humidity-controlled smart window demonstrates superior capabilities in solar modulation (54.4%) and thermal radiation modulation (51.4%). Statistical analysis reveals that compared to ordinary windows and low emissivity (Low-E) windows, PTFE/PVA windows reduce total annual energy consumption by ≈25% and 40%, respectively. This broadband dynamic continuous regulation mechanism may offer groundbreaking insights into the advancement of smart window technologies.}, archive = {J_ADVS}, author = {Guozheng Li and Xiaofeng Jiang and Hafiz Asfahan and Siyuan Jia and Sujin Shao and Xiuqiang Li}, doi = {10.1002/advs.202506980}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06980}, shortjournal = {Adv. Sci.}, title = {Humidity-controlled smart window with synchronous solar and thermal radiation regulation}, volume = {12}, year = {2025}, }
• (2025). Minimally invasive, bioadaptive multimodal sensor probe with safe deployment for real-time acute compartment syndrome diagnosis. ADVS, 12(33), e06942. (www)

  @article{ , abstract = {Acute Compartment Syndrome (ACS) is a serious medical condition that arises from increased pressure within osteofascial compartments, leading to impaired blood flow and potential tissue damage. Early and accurate diagnosis is critical for preventing permanent damage. Current methods rely largely on qualitative assessments with limited accuracy, and those that exploit invasive pressure measurements often prove inadequate. Herein, a soft materials-based multimodal sensor probe is introduced, as well as the mechanical and thermal influences to monitor intra-compartmental pressure, tissue oxygen saturation (StO 2 ), and blood flow simultaneously at a common location within an affected compartment. The system integrates three sensors into a thin, flexible probe capable of real-time, wireless data transmission. The device allows for continuous monitoring with high reproducibility and sensitivity, to enhance diagnostic accuracy relative to current clinical practice, with the potential to early diagnosis of an acute compartment syndrome that requires fasciotomies. Large animal model studies, including short- and intermediate-term reliability assessments, highlight the key engineering features. The results reveal expected inverse relationships between pressure, StO 2 , and flow rate under simulated compartment syndrome conditions. This multimodal approach enhances diagnostic precision, offers real-time insights, and promises to yield improved outcomes through a comprehensive, quantitative diagnosis of compartment syndrome.}, archive = {J_ADVS}, author = {Seung Gi Seo and Seungyeob Kim and Seonggwang Yoo and Seyong Oh and Haiwen Luan and Zengyao Lv and Bosung Kim and Shupeng Li and Di Lu and Jong Uk Kim and Yaeshin Park and Jae Hee Lee and Hyeon Bin Jo and Amanda M. Westman and William Moritz and Joseph Ribaudo and Yonggang Huang and Mitchell A. Pet and Sung Hun Jin and John A. Rogers}, doi = {10.1002/advs.202506942}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06942}, shortjournal = {Adv. Sci.}, title = {Minimally invasive, bioadaptive multimodal sensor probe with safe deployment for real-time acute compartment syndrome diagnosis}, volume = {12}, year = {2025}, }
• (2025). ASO therapy targeting STAU2 to inhibit pancreatic ductal adenocarcinoma progression and metastasis by regulating the PALLD-mediated EMT signaling pathway. ADVS, 12(33), e06718. (www)

  @article{ , abstract = {Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy marked by high morbidity, recurrence, and metastasis, with limited treatment options and poor prognosis. The challenge of early diagnosis and the inefficacy of current therapeutic strategies underscore the urgent need for novel biomarkers and therapeutic targets. RNA-binding proteins (RBPs) are emerging as critical regulators of post-transcriptional processes and are implicated in cancer progression. Here, the study identifies Staufen Double-Stranded RNA Binding Protein 2 (STAU2) as an oncogenic RBP with high expression in PDAC, which is significantly associated with metastasis. It is demonstrated that STAU2 directly binds and regulates cytoskeletal associated protein Palladin (PALLD) and mediates IQ motif containing GTPase-activating protein 1 (IQGAP1), thereby promoting metastasis via the epithelial-mesenchymal transition (EMT) pathway. Moreover, a 2′-methoxyethoxy (2′-MOE)-modified antisense oligonucleotide (ASO) targeting STAU2 is developed, which effectively inhibited downstream targets in vitro and in vivo. STAU2-ASO treatment significantly suppressed PDAC progression and metastasis, with a demonstrated safety profile in vivo.}, archive = {J_ADVS}, author = {Jiayu Ding and Hao Shen and Jiaying Ji and Jiaxing Li and Zhongrui Shi and Xuejiao Wang and Bangbang Li and Yi Hou and Wenjian Min and Chengliang Sun and Kai Yuan and Yasheng Zhu and Liping Wang and Shun-Qing Liang and Wenbin Kuang and Xiao Wang and Peng Yang}, doi = {10.1002/advs.202506718}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06718}, shortjournal = {Adv. Sci.}, title = {ASO therapy targeting STAU2 to inhibit pancreatic ductal adenocarcinoma progression and metastasis by regulating the PALLD-mediated EMT signaling pathway}, volume = {12}, year = {2025}, }
• (2025). ROS-responsive hydrogel for localized delivery of nampt and stat3 inhibitors exhibits synergistic antitumor effects in colorectal cancer through ferroptosis induction and immune microenvironment remodeling. ADVS, 12(33), e06599. (www)

  @article{ , abstract = {Targeting Nampt to modulate NAD + metabolism and exert antitumor effects has become a research hotspot in the field of cancer metabolism. But early clinical trials have only achieved modest results, primarily due to the need for improved efficacy and the occurrence of severe systemic adverse effects. Therefore, enhancing antitumor efficacy and reducing the adverse effects of Nampt inhibitors are urgent challenges. The research reveals that the Nampt inhibitor FK866 can induce ferroptosis in colorectal cancer cells via the NAD + /Stat3/Gpx4 signaling axis. Furthermore, the combination of FK866 and the Stat3 inhibitor C188-9 demonstrates a strong synergistic antitumor effect. Importantly, a reactive oxygen species (ROS)-responsive hydrogel that encapsulates FK866 and C188-9 for in situ drug delivery, effectively reducing systemic side effects, is developed. Intriguingly, mass cytometry time-of-flight (CyTOF) analysis indicates that the combined treatment with FK866 and C188-9 exerts antitumor effects by increasing the infiltration of CD8 + T cells and neutrophils into the tumor, as well as enhancing the expression of immune-regulatory molecules, including IFN-γ, IL-10, and perforin. Thus, this localized treatment not only minimizes systemic adverse effects, but also markedly amplifies antitumor efficacy through the modulation of both tumor cells and the tumor immune microenvironment, representing a promising antitumor treatment strategy.}, archive = {J_ADVS}, author = {Chenyang Ye and Mi Mi and Saimeng Shi and Lina Qi and Shanshan Weng and Lu Wang and Yier Lu and Chao Chen and Yinuo Tan and Mengyuan Yang and Cheng Guo and Rui Bai and Xuefeng Fang and Ji Wang and Ying Yuan}, doi = {10.1002/advs.202506599}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06599}, shortjournal = {Adv. Sci.}, title = {ROS-responsive hydrogel for localized delivery of nampt and stat3 inhibitors exhibits synergistic antitumor effects in colorectal cancer through ferroptosis induction and immune microenvironment remodeling}, volume = {12}, year = {2025}, }
• (2025). MXene-engineered Cs2AgBiBr6 perovskite solar cells: Rational screening and interfacial dynamics for lead-free photovoltaics. ADVS, 12(33), e06567. (www)

  @article{ , abstract = {MXenes have demonstrated exceptional performance in energy applications, yet their potential in photovoltaic systems, particularly in lead-free perovskite solar cells (PSCs), remains underexplored, with no strategic studies addressing how MXene composition influences critical photovoltaic performance. Here, we present the first strategic screening of M 2 X-type MXenes (including Hf 2 CT x , Zr 2 CT x , Ta 2 CT x , Nb 2 CT x , Mo 2 CT x , and V 2 CT x ) for rational heterojunction design with Cs 2 AgBiBr 6 , focusing on the interplay between properties of MXenes and photovoltaic performance. Density functional theory (DFT) calculations reveal that MXenes can induce substantial electronic states near the Fermi level, creating superior charge transfer paths in Cs 2 AgBiBr 6 , with V 2 CT x exhibiting the lowest interfacial contact barrier and the highest carrier transfer efficiency. Complementary ab initio molecular dynamics (AIMD) simulations coupled with X-ray photoelectron spectroscopy analyses further demonstrate that the functional termination groups like ─F in MXenes effectively passivate Br vacancies in Cs 2 AgBiBr 6 , thereby enhancing crystallization and suppressing defect densities. Consequently, the experimental results yielded a trend in line with the calculations, and the power conversion efficiency (PCE) of the device with V 2 CT x represented a 36% improvement, accompanied by exceptional stability. By establishing quantitative structure-property relationships between MXenes and Cs 2 AgBiBr 6 , this work provides a universal materials selection paradigm for developing high-performance, environmentally-friendly photovoltaic technologies.}, archive = {J_ADVS}, author = {Lin Yang and Tianfang Zheng and Ziyan Liu and Naoyuki Shibayama and Peng Li and Jiangang Ma and Xintong Zhang and Hancheng Zhu and Xiao-Feng Wang and Haiyang Xu and Yichun Liu}, doi = {10.1002/advs.202506567}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06567}, shortjournal = {Adv. Sci.}, title = {MXene-engineered Cs2AgBiBr6 perovskite solar cells: Rational screening and interfacial dynamics for lead-free photovoltaics}, volume = {12}, year = {2025}, }
• (2025). WTAP mediated m6A modification stabilizes PDIA3P1 and promotes tumor progression driven by histone lactylation in esophageal squamous cell carcinoma. ADVS, 12(33), e06529. (www)

  @article{ , abstract = {Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant cancer with high incidence and mortality rate. Many studies have shown that long noncoding RNAs (lncRNAs are involved in the progression of various types of tumors. The lncRNA protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) promotes the progression of ESCC, but the molecular mechanism behind this is still unclear. In this study, PDIA3P1 is highly expressed in ESCC, produces more lactate by regulating glycolysis, and the increased lactate upregulates lactylation levels to drive tumor progression. Mechanistically, PDIA3P1 competes with miR-152-3p to prevent degradation of glucose transporter 1 (GLUT1) mRNA, and disrupts the binding between membrane-associated RING-CH 8 (MARCH8) and hexokinase 2 (HK2) to reduce ubiquitination degradation of HK2, thereby promoting glycolysis. High activity glycolysis produces more lactate, which upregulates the level of histone H4K8 lactylation (H4K8la) and promotes the transcription of target bone morphogenic protein 7 (BMP7). Functionally, BMP7 is involved in the regulation of ESCC progression by PDIA3P1 both in vivo and in vitro. In addition, wilms tumor 1-associated protein (WTAP) mediated m6A modification enhances the stability of PDIA3P1 through Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) dependent recognition. Taken together, these findings reveal the key role of PDIA3P1 regulates glycolysis-H4K8la-BMP7 axis in the progression of ESCC and provides new insights into the interplay between metabolic reprogramming and epigenetic regulation.}, archive = {J_ADVS}, author = {Tao Huang and Qi You and Jiawei Liu and Xuguang Shen and Dengjun Huang and Xinlu Tao and Zhijie He and Chengwei Wu and Xinran Xi and Shouqiang Yu and Feng Liu and Zhihao Wu and Wenjun Mao and Shaojin Zhu}, doi = {10.1002/advs.202506529}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06529}, shortjournal = {Adv. Sci.}, title = {WTAP mediated m6A modification stabilizes PDIA3P1 and promotes tumor progression driven by histone lactylation in esophageal squamous cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Electrolyte transport parameters and interfacial effects in calcium metal batteries: Analogies and differences to magnesium and lithium counterparts. ADVS, 12(33), e06498. (www)

  @article{ , abstract = {Magnesium and calcium metal batteries are promising emerging technologies. Their high capacity and low redox potential translate to a high theoretical energy density, making them attractive candidates for future energy storage solutions. Owing to their neighboring position and the diagonal relationship in the periodic table to lithium, Mg 2+ , Ca 2+ , and Li + ions feature commonalities in terms of ionic radius, carried charge, and charge density. The present study aims to shed light on the similarities but also differences of Ca electrolytes and metal anodes in comparison to their Mg and Li counterparts in terms of transport properties and processes at the anode/electrolyte interface, respectively. To ensure comparability, an electrolyte comprising B(hfip) 4 − anions in monoglyme is applied in either case. By executing galvanostatic polarization and pulsing with different separator materials, the separator tortuosity, diffusion coefficient, and transference number are determined. Further, the charge transfer characteristics as well as the adsorption layer and solid electrolyte interphase formation are investigated by electrochemical impedance spectroscopy. The cation charge density was found to be crucial for diffusion and desolvation processes, yet surprisingly, also a cation-dependent separator tortuosity was observed. The study concludes with a recommendation on suitable separators for each metal battery system.}, archive = {J_ADVS}, author = {Joachim Häcker and Tobias Rommel and Laurin Rademacher and Sibylle Riedel and Zhirong Zhao-Karger and J. Alberto Blázquez and K. Andreas Friedrich and Maryam Nojabaee}, doi = {10.1002/advs.202506498}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06498}, shortjournal = {Adv. Sci.}, title = {Electrolyte transport parameters and interfacial effects in calcium metal batteries: Analogies and differences to magnesium and lithium counterparts}, volume = {12}, year = {2025}, }
• (2025). Temporal evolution of lithium metal microstructures during ultra-high-capacity Stripping/Plating cycles. ADVS, 12(33), e06474. (www)

  @article{ , abstract = {The morphology of deposited lithium (Li) is critical to the stability and reversibility of Li-metal batteries (LMBs). While crystallographic features of Li influence deposition morphology, the orientation of Li crystals during electrodeposition and their temporal evolution under varying kinetic and interphasial conditions remain unclear. This study investigates Li microstructures during electrodeposition at ultra-high capacities (up to 12 mAh cm⁻ 2 ) and over repeated cycling, using scanning electron microscopy (SEM) and electron backscatter diffraction (EBSD). The results show that the microstructural evolution of Li depends on the interplay between interphasial properties and deposition kinetics. A layer-by-layer epitaxial Li growth with a coherent lattice orientation is achievable under homogeneous interphase and slow deposition kinetics. However, at higher capacities or extended cycling, deterioration of interphase homogeneity disrupts crystal matching, resulting in island-like deposits with randomly oriented single-crystalline grains. In contrast, an inhomogeneous interphase and faster kinetics lead to whisker-like Li deposits. These results demonstrate that while cohesive interactions between depositing Li crystals can result in isolated single-crystalline grains, maintaining interphase homogeneity and stability is essential to enable coherent lattice matching for layer-by-layer epitaxial growth. This study reveals Li microstructural evolution and offers insights for designing stable interphases and optimizing conditions for durable, high-capacity LMBs.}, archive = {J_ADVS}, author = {Arghya Dutta and Yoshimi Kubo}, doi = {10.1002/advs.202506474}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06474}, shortjournal = {Adv. Sci.}, title = {Temporal evolution of lithium metal microstructures during ultra-high-capacity Stripping/Plating cycles}, volume = {12}, year = {2025}, }
• (2025). Simple protein foaming-derived 3D segregated MgO networks in epoxy composites with outstanding thermal conductivity properties. ADVS, 12(33), e06465. (www)

  @article{ , abstract = {The miniaturization and high-power density of electronic devices present new challenges for thermal management. Efficient heat dissipation in electrically insulating packaging materials is currently limited by the thermal conductivity of thermal-interface materials (TIMs) and their ability to effectively direct heat toward heat sinks. In this study, MgO-based composites with high thermal conductivities are fabricated to achieve excellent thermal performances by optimizing the heat-transfer path. These composites are produced using a protein foaming method, which effectively forms interconnected ceramic-filler networks. Additionally, the liquid phase formed during the sintering of MgO enhances the bonding with the epoxy matrix, thereby improving the thermal conductivity of the composites. As a result, the composites with 54.64 vol% MgO achieve a high thermal conductivity of 17.19 W m −1 K −1 , which is 101 times higher than that of pure epoxy, 3.7 times higher than that of randomly dispersed composites, and even superior to that of nitride-based composites. Moreover, the composites also exhibited a low thermal-expansion coefficient (27.76 ppm °C −1 ) and high electrical-insulation strength (51.51 kV mm −1 ), ensuring good thermal and electrical performance for electronic-packaging applications. The strategic design of the TIM microstructures for effectively directing heat offers a promising solution for efficient thermal management in integrated electronics.}, archive = {J_ADVS}, author = {Su-Jin Ha and Young Kook Moon and Jong-Jin Choi and Byung-Dong Hahn and Cheol-Woo Ahn and Kyung-Hoon Cho and Hyun-Ae Cha}, doi = {10.1002/advs.202506465}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06465}, shortjournal = {Adv. Sci.}, title = {Simple protein foaming-derived 3D segregated MgO networks in epoxy composites with outstanding thermal conductivity properties}, volume = {12}, year = {2025}, }
• (2025). Overcoming the Damping–Elasticity paradox via 3D-printed NiTiSn nanocomposite. ADVS, 12(33), e06410. (www)

  @article{ , abstract = {Developing high damping alloys (HDAs) with large elastic strain has attracted growing attention due to the increasing demand for energy absorption with overload reliability and reusability. However, damping capacity inherently conflicts with elasticity, because the former requires a liable movement of crystal defects while the latter opposite. To deal with the damping-elasticity paradox, the advantage of pseudobinary eutectic reaction and rapid cooling of laser powder bed fusion is taken to fabricate a bulk NiTiSn nanocomposite with a two-level hierarchical structure. The first-level architecture is composed of martensitic NiTi nanolamellae and reinforced Ti 3 Sn nanolamellae. In addition to lattice strain matching and lamellar boundary strengthening, a novel mechanism of martensite reorientation mediated by reversible stress-induced detwinning-twinning is activated to generate large elastic strain. A high density of nanotwins and nanodomains within NiTi nanolamellae constitute the second-level architecture, which provides pronounced internal friction for high damping capacity. As a result, our NiTiSn nanocomposite exhibits a record-high integration of damping capacity (tanδ > 0.10) and elastic strain (exceeding 4.5%), as well as superb stability under cyclic overload. This research not only represents a major breakthrough in achieving HDAs with outstanding damping and elastic strain but also offers a novel paradigm for high-performance functional and structural materials.}, archive = {J_ADVS}, author = {Bo Feng and Helong Liu and Hui Shen and Ying Yang and Fangmin Guo and Lishan Cui and Yang Ren and Jie Chen and Shuke Huang and Yao Xiao and Zhihui Zhang and Hongxiang Zong and Yinong Liu and Shijie Hao}, doi = {10.1002/advs.202506410}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06410}, shortjournal = {Adv. Sci.}, title = {Overcoming the Damping–Elasticity paradox via 3D-printed NiTiSn nanocomposite}, volume = {12}, year = {2025}, }
• (2025). Enhancing chemotherapy-related immune responses via bioorthogonal metabolic engineering-driven tumor exosomes elimination. ADVS, 12(33), e06409. (www)

  @article{ , abstract = {Tumor cell-driven exosomes (TExo) have exhibited several major drawbacks that hinder antitumor therapy. A representative immunosuppressive mechanism is the depletion of CD8+ cytotoxic T cells with the help of exosomal PD-L1. Another common mechanism is to promote tumor metastasis by promoting the seeding and growth of metastatic cancer cells in distant organs. Therefore, the removal of TExo can provide many benefits for the treatment of cancer patients. Here, a bio orthogonal r eaction- d riven e xosome e limination (Biordee) strategy that promoted macrophage-mediated phagocytosis by using IgG Fc to engineer endogenous TExo (TExo-Fc) was developed. The Biordee strategy effectively reduced the levels of TExo in the circulatory system by leveraging the interaction of IgG Fc with FcγRII/III receptors of macrophage, which further broke down the body's immunosuppression and enhanced the immune response after chemotherapy. Moreover, the Biordee strategy inhibited breast cancer liver metastases, which were enhanced by promoting chemotherapy-induced TExo release. This work provided a new attempt to reduce TExo level after chemotherapy to enhance antitumor therapeutic effects.}, archive = {J_ADVS}, author = {Wentao Zhang and Tianyi Yang and Tian Jin and Tianyi Zhu and Fang Hao and Miao Fan and Yanrong Zhang}, doi = {10.1002/advs.202506409}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06409}, shortjournal = {Adv. Sci.}, title = {Enhancing chemotherapy-related immune responses via bioorthogonal metabolic engineering-driven tumor exosomes elimination}, volume = {12}, year = {2025}, }
• (2025). Ligand-engineered Metal–Organic frameworks of 3D infinite trinuclear zinc units for photocatalytic monooxygenation of sulfenamides. ADVS, 12(33), e06037. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) composed of infinite metal units exhibit enhanced electron transport and charge migration capabilities compared to discrete metal units. Herein, three underdeveloped isomorphic MOFs featuring 3D infinite zinc units are designed and synthesized. The Lewis acidity and photocatalytic activity of these MOFs are fine-tuned through atomic-level engineering of nitrogen atoms of ligands and the resultant change of charge transfer modes. These MOFs are promising catalysts in the photocatalytic monooxygenation of sulfenamides with molecular oxygen. Mechanistic investigations suggest that the uneven charge distribution and large dipole moment at the pyridine center of 1-PTB and the infinite Zn unit frameworks of degenerate energy levels are key to its excellent photocatalytic activity.}, archive = {J_ADVS}, author = {Xinglei He and Chunlong Yu and Fengtao Zhang and Chenxu Gong and Jingheng Li and Ding-Bo Zeng and Bin Zhao and Xiong Chen and Ke-Yin Ye}, doi = {10.1002/advs.202506037}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06037}, shortjournal = {Adv. Sci.}, title = {Ligand-engineered Metal–Organic frameworks of 3D infinite trinuclear zinc units for photocatalytic monooxygenation of sulfenamides}, volume = {12}, year = {2025}, }
• (2025). Manipulating Unisexual–Sexual reproduction transition to engineer genome-reconstructed polyploids. ADVS, 12(33), e06024. (www)

  @article{ , abstract = {Both unisexuality and polyploidy are significant in agriculture, exhibiting revolutionary biotechnology potential, as their coupling has been demonstrated to enable the design of polyploid genomes in crops. However, their applicability to animals has remained a challenge. Herein, the first case of engineering polyploid genomes with desirable traits via unisexual–sexual reproduction transition is provided. First, a group of genome-reconstructed amphitriploids (GR-A3n) is generated involving unisexual gynogenetic Carassius gibelio , sexual C. auratus , and sexual C. cuvieri . Then, we found that the gynogenesis ability have transferred from C. gibelio to some of the GR-A3n females. This study subsequently established three GR-A3n clones with distinct herpesvirus resistance and in which differential transcriptome profiles are characterized in two main hematopoietic organs. Most genes of the hemoglobin metabolism pathway is found to exhibit high expression levels, as in C. cuvieri , which led to efficient hemoglobin biosynthesis and blood oxygen homeostasis during infection, thereby resulting in strong herpesvirus resistance. Furthermore, this study determined the resistant and susceptible haplotypes derived from chromosome 12B of C. cuvieri , which should be responsible for resistance differences between GR-A3n clones. Overall, this study establishes an approach for genetic improvement through polyploid genome design in animals.}, archive = {J_ADVS}, author = {Meng Lu and Qin-Can Zhang and Zi-Yu Zhu and Yang Wang and Zhong-Wei Wang and Xi-Yin Li and Zhi Li and Xiao-Juan Zhang and Li Zhou and Jian-Fang Gui}, doi = {10.1002/advs.202506024}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e06024}, shortjournal = {Adv. Sci.}, title = {Manipulating Unisexual–Sexual reproduction transition to engineer genome-reconstructed polyploids}, volume = {12}, year = {2025}, }
• (2025). Metabolic programming drives protective and inflammatory monocyte fates in viral encephalitis. ADVS, 12(33), e05844. (www)

  @article{ , abstract = {Infiltrating monocytes can exert both protective and pathogenic effects during central nervous system (CNS) inflammation. However, the metabolic mechanisms that govern these divergent roles remain poorly understood, limiting opportunities for therapeutic intervention. Single-cell RNA-sequencing and metabolic flow analysis of brain and bone marrow (BM) is used to map the metabolic signatures of monocyte-derived cells (MCs) during lethal West Nile virus encephalitis. Trajectory analysis shows that BM monocytes progress through three metabolic profiles before migrating to the brain and differentiating into a pro-inflammatory HIF1-α⁺ MC population. This population further diverges into an inflammatory, iNOS⁺ MC subset with high glycolysis and amino acid metabolism, and a protective, glycolytically quiescent, antigen-presenting MC subset. Daily in vivo glycolysis inhibition reduces neuroinflammation and disease signs without increasing viral load. This effect does not reflect a broad reduction in myelopoiesis but rather a selective decrease in iNOS⁺ MC migration, revealing distinct glycolytic dependencies among MC subsets. HIF1-α activity remains independent of glycolysis, enabling functional differentiation of antigen-presenting MCs without impairing antiviral responses by cervical lymph node T cells. This study identifies key metabolic drivers of MC function in viral CNS disease, in which selective metabolic reprogramming reduces severe neuroinflammation, demonstrating a promising therapeutic strategy.}, archive = {J_ADVS}, author = {Claire L. Wishart and Alanna G. Spiteri and Jian Tan and Laurence Macia and Nicholas J. C. King}, doi = {10.1002/advs.202505844}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05844}, shortjournal = {Adv. Sci.}, title = {Metabolic programming drives protective and inflammatory monocyte fates in viral encephalitis}, volume = {12}, year = {2025}, }
• (2025). Micro-environment programmable quinoline COFs for high-performance photocatalytic H2O2 generation and benzylamine coupling. ADVS, 12(33), e05794. (www)

  @article{ , abstract = {Photocatalytic H 2 O 2 synthesis from water and oxygen by covalent organic frameworks (COFs) has attracted much attention currently. However, conventional COFs often suffer from insufficient stability and activity due to the unclear structure-activity relationship mechanisms. Herein, a series of quinoline-linked COFs-R (-R = -OH, -OMe, -H, -Br, -CN) synthesized via multi-component reactions (MCRs) is reported to systematically modulate their pore microenvironments and enhance photocatalytic performance. Experimental results reveal that the electron-donating capacity of substituents significantly enhances charge separation efficiency, with H 2 O 2 production activity exhibiting a negative correlation to the Hammett parameters ( σ p ) of the -R groups. Notably, the COF-OH and COF-OMe, bearing the strong electron-donating group, achieve a remarkable H 2 O 2 generation rate of 4458 and 4138 µmol g⁻¹ h⁻¹ in the pure water system. Theoretical calculations confirm that substituents optimize the collective donor structure within the π-conjugated triazine framework, boosting photocatalytic activity. Furthermore, the universal Hammett relationship observed in benzylamine coupling reactions establishes a critical structure-activity model for rational COF design. This work provides fundamental insights into the microenvironment engineering of COFs for efficient H 2 O 2 production and advances the development of sustainable photocatalytic materials.}, archive = {J_ADVS}, author = {Mengchao Guo and Chao He and Zihe Wu and Yu Tian and Jiani Yang and Yujie Wang and Hao Wu and Jin Yang and Min Xu and Weichao Xue and Chong Cheng and Shuang Li and Changsheng Zhao}, doi = {10.1002/advs.202505794}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05794}, shortjournal = {Adv. Sci.}, title = {Micro-environment programmable quinoline COFs for high-performance photocatalytic H2O2 generation and benzylamine coupling}, volume = {12}, year = {2025}, }
• (2025). The role of CAF-derived vitronectin in promoting colorectal cancer progression and immunosuppression. ADVS, 12(33), e05769. (www)

  @article{ , abstract = {Cancer-associated fibroblasts (CAFs) dominate the tumor stroma in colorectal cancer (CRC), fostering an immunosuppressive microenvironment that supports tumor growth, metastasis, and therapy resistance. Targeting CAF-derived cytokines and secreted proteins offers potential new avenues for CRC treatment. Here, vitronectin (VTN) is identified as a significantly up-regulated gene in CAFs, correlated with poor prognosis in CRC patients, through multi-dataset analysis and multiplex immunofluorescence. Comprehensive analyses, including cytometry by time -of- flight (CyTOF), in vitro co-culture assays, transgenic mouse models, and azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC models, demonstrate that VTN enhances CRC proliferation, metastasis, and resistance to therapy. CyTOF analysis shows a reduced proportion of M2-type macrophages in fibroblast-specific VTN knockout mice ( Vtn fl/fl S100a4-Cre + ), with VTN promoting M2 macrophage polarization in vitro. Mechanistically, VTN upregulates SLC6A8 expression in CRC cells and macrophages by enhancing FAK phosphorylation, which increases creatine and ATP uptake, promoting cancer progression and macrophage polarization. Targeted VTN knockout in fibroblasts significantly improves the efficacy of immunotherapies and reduces CRC progression. These findings highlight the dual role of CAF-derived VTN in driving CRC malignancy and modulating immune responses, positioning VTN as a promising therapeutic target in CRC management.}, archive = {J_ADVS}, author = {Jiahua Yu and Mengxi Xiu and Shijun Yu and Zhiqin Chen and Yandong Li and Yong Gao}, doi = {10.1002/advs.202505769}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05769}, shortjournal = {Adv. Sci.}, title = {The role of CAF-derived vitronectin in promoting colorectal cancer progression and immunosuppression}, volume = {12}, year = {2025}, }
• (2025). Integrated design of electrically configurable ferroelectric and redox-based memristors for hardware-implemented reservoir computing. ADVS, 12(33), e05688. (www)

  @article{ , abstract = {Reservoir computing (RC) offers advantages in processing time-series data with reduced training costs and simpler architectures. This study presents a hardware-implemented RC system utilizing multifunctional memristors fabricated using a single process. By leveraging a ferroelectric-based memristor (FM) as a volatile reservoir layer and a redox-based memristor (RM) as a non-volatile readout layer, seamless integration without additional fabrication steps is achieved. The dual-functional memristor structure enables electrical conversion from FM to RM, enhancing system scalability and versatility. Comprehensive electrical measurements, including low-frequency noise analysis and weight update linearity evaluation, validate the memristors’ performance. Potentiation and depression processes achieve a linearity factor improvement to ensure precise synaptic weight tuning, with cycle-to-cycle variation <2.3%. Additionally, the ferroelectric-based memristor exhibits a cycle-to-cycle variation of 3.52%, maintaining distinct reservoir states with minimal overlap. Offline training demonstrates a high classification accuracy of 93.3% on the Modified National Institute of Standards and Technology dataset, while online training achieves an accuracy of 88.2% with incremental pulse schemes, surpassing the accuracy of identical pulse schemes (65.1%). These results establish the practical viability of multifunctional memristors for neuromorphic systems, establishing a robust foundation for next-generation computing technologies}, archive = {J_ADVS}, author = {Jung-Kyu Lee and Yongjin Park and Euncho Seo and Jong-Ho Lee and Sungjoon Kim and Sungjun Kim}, doi = {10.1002/advs.202505688}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05688}, shortjournal = {Adv. Sci.}, title = {Integrated design of electrically configurable ferroelectric and redox-based memristors for hardware-implemented reservoir computing}, volume = {12}, year = {2025}, }
• (2025). BRD4 signaling maintains the differentiated state of β cells. ADVS, 12(33), e05659. (www)

  @article{ , abstract = {In diabetes, pancreatic β cells degenerate from their mature differentiated state to a dedifferentiated state. BRD4 plays a pivotal role during embryogenesis and cancer development, but its function in modulating β-cell differentiation remains unknown. In this study, multiple models including calorie restriction db/db mouse, long-term and acute conditional knockout mouse, and human islet organoids are adopted to assess BRD4 function in β cells. Two hundred twenty-two young patients with diabetes are also recruited for whole exome sequencing (WES) to screen for BRD4 mutations. This study shows that BRD4 expression is significantly reduced in human diabetic β cells while significantly increased after calorie restriction in the diabetic mouse. β cell differentiation is impaired after long-term and acute Brd4 knockout. BRD4 knockdown in human islet organoids results in the loss of differentiation and reduction of insulin synthesis. It is found that p.R749C can significantly affect BRD4 signaling and might play roles in diabetes development in patients. This study also shows that ATF5 is a direct target of the BRD4 pathway in β cells. Targeting BRD4-mediated regulatory networks may hold promise for developing novel therapeutic strategies to maintain the differentiated state of β cells.}, archive = {J_ADVS}, author = {Fuqiang Liu and Guang Liu and Jia Song and Yujing Sun and Mengmeng Yang and Hualin Liu and Hongkai Zhao and Jiamu Chen and Qincheng Qiao and Siyue Li and Chenglong Yu and Jingru Qu and Ying Zou and Tixiao Wang and Jidong Liu and Lei Zhao and Huihui Tian and Tao Huang and Manna Zhang and Li Chen and Ruxing Zhao and Yuanyuan Du and Xinguo Hou}, doi = {10.1002/advs.202505659}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05659}, shortjournal = {Adv. Sci.}, title = {BRD4 signaling maintains the differentiated state of β cells}, volume = {12}, year = {2025}, }
• (2025). Spin-orbit angular momentum conversion in coupled nonparaxial bessel acoustic vortices. ADVS, 12(33), e05631. (www)

  @article{ , abstract = {Acoustic waves as longitudinal waves are recently demonstrated to have both spin and orbital angular momentums (AMs). The separation of orbital and spin components is proposed as the most current idea. However, it remains extremely difficult to develop studies sensitive to both types of AM using direct wave field measurements. Here, theoretical explanation and experimental proof of the acoustic spin-orbit AM conversion are reported. A formulaic description of spin-orbit AM conversion in coupled fields of two nonparaxial Bessel acoustic vortices is given by a thorough theoretical derivation. Experimental results of wave field measurements provide compelling evidence for spin-orbit AM conversion via passive artificial structures. Based on this conversion, contactless high-resolution manipulation of micro-objects is further achieved, as demonstrated by the controlled rotation of Rayleigh particles and their translation along a circular trajectory. This work provides deeper insights into the AM physics of classical waves and has significant implications for acoustic sensing, acoustic imaging, and particle manipulation based on acoustic radiation force or torque.}, archive = {J_ADVS}, author = {Di-Chao Chen and Qian Mo and Da-Jian Wu and Xing-Feng Zhu and Ying Cheng and Xiao-Jun Liu}, doi = {10.1002/advs.202505631}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05631}, shortjournal = {Adv. Sci.}, title = {Spin-orbit angular momentum conversion in coupled nonparaxial bessel acoustic vortices}, volume = {12}, year = {2025}, }
• (2025). Low-κ extension doping for high-performance carbon nanotube transistors: Toward high-speed, energy-efficient electronics. ADVS, 12(33), e05543. (www)

  @article{ , abstract = {Carbon nanotubes (CNTs) present considerable potential as next-generation logic switches owing to their ultra-thin structure and exceptional electrical properties. Although recent advancements have achieved impressive direct current (DC) performance in individual devices, research on the architectural design of CNT-based transistors remains limited. This gap is critical, as device architecture directly influences power consumption and switching speed at the circuit level. In particular, the balance between parasitic capacitance and resistance, key factors determining resistive-capacitive (RC) delay, has not been thoroughly addressed. In this study, top-gate CNT metal–oxide–semiconductor field-effect transistors (MOSFETs) that employ a novel low-κ extension doping technique are presented. This approach utilizes a stacked SiO x /AlF x layer (κ = 3.9 and 2.5) to enhance device performance while minimizing parasitic capacitance between the top gate and contact metal. The proposed approach improves the driving current by 8.4 times and reduces the total resistance by 85% when compared with CNT MOSFETs with undoped extensions. The doping level is tunable from 0.5 nm −1 to 0.59 nm −1 , with electrostatic doping driven by negative charges at the SiO x ​/AlF x interface. The benchmarking results demonstrate the record-low κ-value and physical thickness presented by the proposed approach, highlighting its potential for high-performance, high-speed applications.}, archive = {J_ADVS}, author = {Hsin-Yuan Chiu and Chen-Han Chou and Guan-Zhen Wu and Han-Yi Huang and Bo-Heng Liu and Chi-Chung Kei and Chao-Hsin Chien}, doi = {10.1002/advs.202505543}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05543}, shortjournal = {Adv. Sci.}, title = {Low-κ extension doping for high-performance carbon nanotube transistors: Toward high-speed, energy-efficient electronics}, volume = {12}, year = {2025}, }
• (2025). Eutectic-like ion-conductive phase-incorporated zwitterionic covalent organic framework solid electrolyte for all-solid-state li metal batteries. ADVS, 12(33), e05530. (www)

  @article{ , abstract = {High energy-density Li metal batteries with improved safety and cyclic performance can be achieved by adopting solid polymer electrolytes. However, current solid polymer electrolytes show inferior room-temperature ionic conductivity and Li-ion transference number (t Li+ ), impeding their practical applications. Herein, a 3-(pyridinium)propane-1-sulfonate zwitterionic covalent organic framework (PSZ-COF) incorporating a eutectic-like ion-conductive phase is prepared by making a complex with N -methyl- N -propylpyrrolidinium bis(fluorosulfonyl)imide (Pyrrol-FSI) and Li salts in its channels as a solid electrolyte (eutectic PSZ-COF). The eutectic PSZ-COF possesses a zwitterionic Li-salt-dissociating mode, a Pyrrol-FSI Li-cation-transporting carrier, and a pyridinium anion-holding trap in the ordered channels, providing a high ionic conductivity (0.127 mS cm −1 ) and t Li+ (0.62) at room temperature. Moreover, the eutectic PSZ-COF can suppress Li dendrites and drive a LiF/Li 3 N-rich solid electrolyte interface layer on a Li anode. Computational simulations reveal that the time-evolved average distance and hoping distance of Li + ions are significantly reduced in the eutectic PSZ-COF, allowing their facile migration. The all-solid-state Li metal batteries bearing eutectic PSZ-COF with a lithium iron phosphate(LFP) cathode (2.0 mg cm − 2 ) exhibit an initial capacity of 153.3 mAh g −1 , 99.9% Coulombic efficiency, and 100% capacity retention over 150 cycles at room temperature. This study offers an effective route to high-performance solid electrolytes for all-solid-state Li batteries.}, archive = {J_ADVS}, author = {Jaewoo Lee and Jae-Hoon Shin and Sungpyo Hong and Jun-Hyeong Lee and Dae-Hui Jeong and Hongwon Kim and Yong Hui Kim and Sang Uck Lee and Jong-Ho Kim}, doi = {10.1002/advs.202505530}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05530}, shortjournal = {Adv. Sci.}, title = {Eutectic-like ion-conductive phase-incorporated zwitterionic covalent organic framework solid electrolyte for all-solid-state li metal batteries}, volume = {12}, year = {2025}, }
• (2025). Amplifying anti-tumor immune responses via mitochondria-targeting near-infrared photodynamic therapy. ADVS, 12(33), e05525. (www)

  @article{ , abstract = {Pro-inflammatory photodynamic therapy (PDT) holds immense potential to ignite robust and long-lasting systemic anti-tumor immune responses. However, the limited penetration depth of conventional ultra violet (UV)-visible irradiation and the tumor hypoxia microenvironment significantly constrain the efficacy of immune-regulatory PDT. Here, a mitochondria-targeting enhanced nanoplatform (NZ @TG ) is reported, activated by near-infrared (NIR) light-driven PDT, to address these challenges and amplify systemic anti-tumor immunity. This nanoplatform employs an interfacial lanthanide-organic triplet photosensation mechanism to realize localized oxidative damage of oxygen-rich mitochondria under NIR irradiation. Simultaneously, the exacerbated hypoxia induced by PDT activates a TH302 prodrug, resulting in cell cycle arrest in highly proliferative tumor cells. These combined effects trigger immunogenic cell death (ICD), releasing damage-associated molecular patterns (DAMPs) to activate immune responses. This approach demonstrates significantly enhanced tumor ablation in deep-seated lesions in orthotopic liver tumor models and induces long-term anti-tumor immune memory. Moreover, the NIR-PDT-induced immune activation markedly improves the immune checkpoint blockade (ICB) therapy efficacy. This strategy offers a robust modality for immune activation in cancer therapy, paving the way for effective treatment of deep-seated tumors and preventing recurrence.}, archive = {J_ADVS}, author = {Cheng-Ao Li and Junjie Nan and Qingxuan Ye and Bingzhu Zheng and Xiaomeng Dai and Jingya Li and Feng Wang and Huimin Ma and Yu Cheng and Jian Ruan and Weijia Fang and Peng Zhao and Renren Deng and Dong Cen}, doi = {10.1002/advs.202505525}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05525}, shortjournal = {Adv. Sci.}, title = {Amplifying anti-tumor immune responses via mitochondria-targeting near-infrared photodynamic therapy}, volume = {12}, year = {2025}, }
• (2025). Chemical pressure-induced FWHM narrowing in narrowband green phosphors for laser displays with ultra-high saturation thresholds. ADVS, 12(33), e05385. (www)

  @article{ , abstract = {Due to its outstanding performance, laser display technology has received extensive attention. Specifically, in this study, a novel narrow-band green phosphor, Na 0.6 Rb 0.4 BaB 9 O 15 (NRBBO): Eu 2+ , for laser display is obtained. Under chemical pressure, Eu 2+ migrates from Ba 2+ to Na + lattice sites in NRBBO, leading to a gradual decrease in the FWHM, making it more competitive for display applications. The existence of chemical pressure in the lattice is demonstrated through a high-pressure spectrum. The migration of Eu 2+ lattice sites under chemical pressure is verified by XRD refinement, low-temperature spectrum and EXAFS. NRBBO: 0.11Eu 2+ can be effectively excited by NUV and blue light, with an emission peak at 512 nm and a FWHM of 54 nm. It retains 82% of its luminescence intensity at 150 °C compared to room temperature. The luminous flux of NRBBO: 0.11Eu 2+ under 90.7 W mm −2 laser excitation reaches 2081.6 lm without light saturation. Meanwhile, the excellent CL performance demonstrates that NRBBO: 0.11Eu 2+ exhibits stability under high energy density. NRBBO: 0.11 Eu 2+ – based WLED achieves a color gamut of 106% NTSC. The excellent performance of NRBBO: 0.11Eu 2+ demonstrates great potential as a green phosphor for laser display applications.}, archive = {J_ADVS}, author = {Runtian Kang and Zhezhe Su and Chunxu Bao and Yuhua Wang}, doi = {10.1002/advs.202505385}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05385}, shortjournal = {Adv. Sci.}, title = {Chemical pressure-induced FWHM narrowing in narrowband green phosphors for laser displays with ultra-high saturation thresholds}, volume = {12}, year = {2025}, }
• (2025). Large-scale bioprinting of human epiblast-like models featuring disc-shaped morphogenesis and gastrulation events. ADVS, 12(33), e05340. (www)

  @article{ , abstract = {Understanding the initial weeks of human development remains challenging due to ethical concerns and the restricted availability of human embryos. Pluripotent stem cell (PSC)-derived epiblast models mimicking gastrulation processes have sparked significant interest in bridging this gap. However, as a newly emerging field, bioengineered models show limited production throughput and complexity in recapitulating epiblasts’ disc-shaped morphogenesis. Here, a well-defined laminin/alginate bioink to create epiblast-like models from human induced pluripotent stem cells (hiPSCs) using electro-assisted bioprinting is proposed. This approach enables the generation of large-scale hiPSC-laden microgels that not only facilitate mass transfer but also mimic the structural characteristics of early embryos, which allow hiPSCs to self-organize into disc-like epiblast models with consistent morphology and phenotype. With adaptability to human embryonic stem cells, this method demonstrates the versatility of engineering reproducible epiblast-like models using various PSC lineages. Importantly, the bioactive components and physical confinement provided by the bioink, and the endogenous regulation of the WNT signaling pathway, contribute to disc-like morphogenesis, recapitulation of epithelial-to-mesenchymal transition critical in the gastrulation process, and generation of the posterior epiblast population, directing the mass production of manipulable embryonic models for studying the spatiotemporal events and possible defects in early human development.}, archive = {J_ADVS}, author = {Yixue Luo and Liheng Luo and Ling Wang and Shanshan Yang and Hongan Ren and Shaojun Liang and Xiaoyu Wang and Yijun Su and Leqian Yu and Xiaoyue Wang and Mingen Xu and Rui Yao}, doi = {10.1002/advs.202505340}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05340}, shortjournal = {Adv. Sci.}, title = {Large-scale bioprinting of human epiblast-like models featuring disc-shaped morphogenesis and gastrulation events}, volume = {12}, year = {2025}, }
• (2025). The neglected role of GSDMD C-terminal in counteracting type i interferon signaling. ADVS, 12(33), e05255. (www)

  @article{ , abstract = {The GSDMD N-terminal fragment (GSDMD-NT)-mediated pyroptosis is extensively investigated. However, the role of the C-terminal domain of GSDMD (GSDMD-CT) is unexplored. This study demonstrates that GSDMD-CT acts as a negative regulator that suppresses IFN-I signaling during viral infection. Mechanistically, GSDMD-CT, released upon virus infection, interacts separately with retinoic acid-inducible gene I (RIG-I) and tank-binding kinase (TBK1), promoting the selective autophagic degradation of RIG-I via K48-linked polyubiquitination at Lys181 and TBK1 via K27-linked polyubiquitination at Lys487 by the E3 ligase TRIM28, which serves as a recognition signal for the cargo receptor NDP52 and TOLLIP, respectively. Moreover, the P414, Q416, and E459 amino sites are crucial for GSDMD-CT in counteracting antiviral responses. The findings highlight the role of GSDMD-CT in inhibiting antiviral immunity, providing insights into how viruses manipulate host defense mechanisms to enhance infection.}, archive = {J_ADVS}, author = {Weilv Xu and Suhui He and Wen Shi and Jinxia Xu and Shiyang Liu and Zexu Yu and Danyue Li and Qiao Jin and Yumeng Wang and Zian Zhang and Qian Lv and Yuanxiang Ge and Yunjie Li and Xinyue Li and Nan Chen and Xinyu Fu and Yang Yang and Fushan Shi}, doi = {10.1002/advs.202505255}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05255}, shortjournal = {Adv. Sci.}, title = {The neglected role of GSDMD C-terminal in counteracting type i interferon signaling}, volume = {12}, year = {2025}, }
• (2025). BMSC-NFMC model for vascular regulation and interface integration in osteochondral regeneration. ADVS, 12(33), e05222. (www)

  @article{ , abstract = {The core challenge in osteochondral tissue engineering is achieving the dual objectives of precise vascularization regulation and effective interface integration. Current tissue-engineering strategies have limitations in addressing these challenges. This study has regulated BMSC differentiation by optimizing the GT/PCL ratio and topological structure of nanofibrous materials, systematically comparing three different materials (r5G5P, a5G5P, and a7G3P), and employing a “rolling and folding” method in order to construct BMSC-NFMC composite structures. This approach achieves effective vascular isolation between the bone and cartilage layers. After implantation in nude mice, the a5G5P group exhibits distinct natural osteochondral tissue structural characteristics, which become more stable after 8 weeks of in vivo culture. Transcriptome sequencing analysis reveals that under ischemic conditions, the a5G5P group effectively regulates cartilage formation by inhibiting the Rap1 pathway and subsequently activating the ERK pathway. In rabbit articular osteochondral defect repair experiments, the a5G5P group successfully regenerates complete articular osteochondral structures similar to those of the adjacent natural tissues. The BMSC-NFMC structure can be used for both local and long-segment osteochondral defect repair, providing broader possibilities for clinical applications.}, archive = {J_ADVS}, author = {Qian Zhou and Mengjie Hou and Baoshuai Bai and Yiwu Zhang and Yiwei Shen and Zenghui Jia and Yongqiang Guo and Guangdong Zhou and Xiaoqin Liang}, doi = {10.1002/advs.202505222}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05222}, shortjournal = {Adv. Sci.}, title = {BMSC-NFMC model for vascular regulation and interface integration in osteochondral regeneration}, volume = {12}, year = {2025}, }
• (2025). Genetic impacts on the structure and mechanics of cellulose made by bacteria. ADVS, 12(33), e05075. (www)

  @article{ , abstract = {The synthesis of cellulose pellicles by bacteria offers an enticing strategy for the biofabrication of sustainable materials and biomedical devices. To leverage this potential, bacterial strains that overproduce cellulose are identified through directed evolution technology. While cellulose overproduction is linked with a specific genetic mutation, the effect of such mutation on the intracellular protein landscape and on the structure and mechanical properties of the cellulose pellicles is not yet understood. Here, the proteome of bacteria evolved to overproduce cellulose is studied and its effect on the structure and mechanics of the resulting cellulose pellicles is investigated. Proteomic analysis reveals that the protein landscape of the evolved bacteria shows pronounced differences from that of native microorganisms. Thanks to concerted changes in the proteome, the evolved bacteria can generate cellulose pellicles with exquisite structure and improved mechanical properties for applications in textiles, packaging, and medical implants.}, archive = {J_ADVS}, author = {Julie M. Laurent and Mathias Steinacher and Anton Kan and Maximilian Ritter and Mario Leutert and Siiri Bienz and David Häberlin and Naresh Kumar and André R. Studart}, doi = {10.1002/advs.202505075}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05075}, shortjournal = {Adv. Sci.}, title = {Genetic impacts on the structure and mechanics of cellulose made by bacteria}, volume = {12}, year = {2025}, }
• (2025). Stable, highly conductive, and strain-insensitive supramolecular elastomer composite for printable self-healing soft electronics. ADVS, 12(33), e05011. (www)

  @article{ , abstract = {Stretchable and self-healing soft conductive materials are essential for soft electronics, robotics, wearables, and bioelectronics. However, achieving a single material that simultaneously offers high and stable conductivity, minimal resistance changes under extreme stretching, high-resolution universal printability, autonomous self-healing, and pressure-sensitive adhesive properties for direct bonding of surface-mountable components remains challenging. Here, a printable ink composed of liquid metal microparticles and carboxylic acid-functionalized carbon nanotubes, blended into a bimodal supramolecular elastomer matrix is introduced. After photothermal activation, the material is capable of reorganizing conductive pathways and achieves a high conductivity (> 20000 S·cm −1 under strain), exceptional strain insensitivity ( R/R 0 < 3.95 up to 500%), and an elastic working range >700%. The reversible oxygen-boron and hydrogen bonding enable both effective autonomous self-healing and direct assembly of self-healing hybrid electronic circuits and systems through self-adhesiveness. To showcase the high performance and functionality, a highly stretchable, self-healing, and waterproof 3 × 5 pixel display is fabricated.}, archive = {J_ADVS}, author = {Ahmed Albeltagi and Tiia Tyystälä and Mikko Nelo and Tuomo Siponkoski and Aldeliane M. da Silva and Mari Rocham and Jari Hannu and Heli Jantunen and Jari Juuti and Jarkko Tolvanen}, doi = {10.1002/advs.202505011}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e05011}, shortjournal = {Adv. Sci.}, title = {Stable, highly conductive, and strain-insensitive supramolecular elastomer composite for printable self-healing soft electronics}, volume = {12}, year = {2025}, }
• (2025). Q-GEM: Quantum chemistry knowledge fusion geometry-enhanced molecular representation for property prediction. ADVS, 12(33), e04867. (www)

  @article{ , abstract = {Recently, various self-supervised learning (SSL) methods based on 3D graph neural networks (GNNs) have been developed to comprehensively represent the structural information of molecules in 3D space; this is essential for discovering new drugs. However, existing methods fail to comprehensively characterize the 3D structures of molecules and neglect the electronic structural information that significantly influences key properties such as molecular reactivity, strong electrostatic interactions, and chemical adsorption. Therefore, here, a novel molecular representation learning method is constructed, Q-GEM, incorporating quantum and geometric structural information enhancement, based on the quantum chemical property database QuanDB and SSL methods. Q-GEM comprises a GNN embedded with the molecular electronic and complete 3D geometrical structural information as well as several well-designed multiscale SSL tasks, achieving superior absolute molecular conformation prediction and conformational discrimination. The Q-GEM achieved state-of-the-art performance in 12 out of 13 prediction tasks on the MoleculeNet dataset, with an average performance improvement of 3.3% and 2.0% for classification and regression prediction tasks, respectively. Moreover, an average performance improvement of 5.2% is achieved in three localized quantum chemical properties, fully demonstrating the excellent performance of Q-GEM in distinguishing molecular electronic structures. The Q-GEM represents a novel, powerful breakthrough for accurate molecular property prediction.}, archive = {J_ADVS}, author = {Zhijiang Yang and Liangliang Wang and Tengxin Huang and Yunfan Wang and Mingchi Gao and Tingjun Hou and Junjie Ding and Junhua Xiao}, doi = {10.1002/advs.202504867}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e04867}, shortjournal = {Adv. Sci.}, title = {Q-GEM: Quantum chemistry knowledge fusion geometry-enhanced molecular representation for property prediction}, volume = {12}, year = {2025}, }
• (2025). Beyond planar: Enhanced performance of hollow fiber dielectric elastomer actuators. ADVS, 12(33), e04803. (www)

  @article{ , abstract = {Hollow fiber dielectric elastomer actuators (HFDEAs) offer several advantages over their conventional counterpart, planar dielectric elastomer actuators (DEAs). Due to their simple shape, flexibility, and conformability, HFDEAs are promising candidates for complex applications within soft robotics. This paper offers a comprehensive comparison between the actuation behavior of planar and HFDEAs using both analytical and numerical models. An electro-mechanical model establishes analytical correlations between the applied voltage and resulting strain. The results from the simplified model are subsequently compared with a numerical model in COMSOL Multiphysics, where simulations are run in more realistic conditions. Supporting experiments are conducted on HFDEAs with different geometries to validate the model. A geometric factor, β, is introduced to account for the influence of geometric parameters on actuator performance. The results show that HFDEAs exhibit higher strain compared to planar films. Among the different fiber geometries, those with smaller internal diameters and thinner walls exhibit higher axial strain and holding force while using the least amount of material. This study highlights the advantages of hollow fiber DEAs compared to their planar counterparts, especially in applications where lighter, more efficient structures with greater strain capabilities are essential.}, archive = {J_ADVS}, author = {Sina Jafarzadeh and Anne Ladegaard Skov}, doi = {10.1002/advs.202504803}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e04803}, shortjournal = {Adv. Sci.}, title = {Beyond planar: Enhanced performance of hollow fiber dielectric elastomer actuators}, volume = {12}, year = {2025}, }
• (2025). Perovskite neuromorphic engine for transformer architectures. ADVS, 12(33), e04706. (www)

  @article{ , abstract = {Memristive computing refers to the hardware implementation of artificial neural networks (ANNs) by employing memristive devices. It supports analog multiply-and-accumulation (MAC) operation in a compact and highly parallel manner, which can significantly enhance computing efficiency. However, applying memristive computing in advanced network structures, such as deep neural networks and multimodal networks, is inefficient because the partial analog computing requires frequently exchanging data between analog and digital domains. Here, a perovskite memristive computing unit with flexible reconfigurability and desired nonlinearity through fully vapor deposition is reported. It enables performing all the mathematical operations necessary for Transformer ANNs completely in the analog domain. A prototypical attention module is implemented by combining cells configured in different operators of dynamic MAC, activation, and softmax functions. By cascading the modules in a multi-layer Transformer network, a neuromorphic engine is fabricated and tested RGB-T tracking and visual question answering tasks, fully considering device non-idealities. It is found that the network performance is close to that of operating on a graphics processing unit (GPU)-accelerated workstation, but it consumes only 1.7% energy and increases power efficiency by 58 times. The results pave a new way toward efficient and accurate hardware memristive computing for advanced ANNs.}, archive = {J_ADVS}, author = {Zhenye Zhan and Yulu Gao and Yue Liao and Weiguang Xie and Si Liu and Xiaomu Wang}, doi = {10.1002/advs.202504706}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e04706}, shortjournal = {Adv. Sci.}, title = {Perovskite neuromorphic engine for transformer architectures}, volume = {12}, year = {2025}, }
• (2025). A tailored artificial biocatalyst for bacterial endophthalmitis therapy via enhanced ferroptosis-like death. ADVS, 12(33), e04601. (www)

  @article{ , abstract = {Bacterial endophthalmitis is an ophthalmological emergency that can lead to permanent blindness, and high-efficiency therapeutic strategies that can completely eradicate pathogens within a short timeframe are needed. However, intrinsic limitations of this disease, such as low administration frequency and dosage, render most currently available nano-antibacterial strategies inapplicable. To address this challenge, a bio-targeted catalytic strategy that is based on a bacteria-specific artificial biocatalyst (MoS 2 /Fe@mercaptophenylboronic acid@hyaluronic acid, MFBH) and suitable for treating bacterial endophthalmitis is proposed. The results show that MFBH exhibits high-efficiency peptidoglycan-targeted catalytic antibacterial capacity against both standard and clinically isolated strains of Staphylococcus aureus . Notably, the in vivo results demonstrate that MFBH achieves effective treatment of bacterial endophthalmitis at an extremely low dose (≈4 µg kg −1 ) via a single intravitreal injection without causing retinal damage. Importantly, the therapeutic efficacy of MFBH is comparable to that of vancomycin. Mechanistic analysis reveals that MFBH induces enhanced ferroptosis-like bacterial killing by accelerating reactive oxygen species (ROS) burst. Further investigations show that the generation of abundant ROS is closely associated with the sulfur vacancies and exposed of reactive Mo 4+ on the surface of the prepared artificial biocatalyst. In summary, this bacteria-specific artificial biocatalyst provides a promising strategy for treating endophthalmitis.}, archive = {J_ADVS}, author = {Caixia Sun and Yingying Jiang and Shibo Zhang and Zhipeng Ding and Lijun Pu and Xinmei Liu and Jun Yang and Xiangkai Zhuge and Jianjun Dai and Yanmin Ju}, doi = {10.1002/advs.202504601}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e04601}, shortjournal = {Adv. Sci.}, title = {A tailored artificial biocatalyst for bacterial endophthalmitis therapy via enhanced ferroptosis-like death}, volume = {12}, year = {2025}, }
• (2025). A wearable AI-driven mask with humidity-sensing respiratory microphone for non-vocal communication. ADVS, 12(33), e04343. (www)

  @article{ , abstract = {Hoarseness and dysphonia caused by vocal cord conditions or laryngeal surgeries significantly hinder communication and quality of life. This study presents a plug-and-play humidity-sensing respiratory microphone (HSRM) with generalized features for individual users. Leveraging gold nanoparticle-based humidity sensors integrated into commercially available wearable face masks, the system enables patients to produce verbal communication without relying on vocal cord activity. By integrating nanoparticle-enhanced humidity sensors with advanced convolutional neural networks, the HSRM system accurately decodes respiratory patterns into intelligible speech, achieving a recognition accuracy of 85.61%. Leveraging nanoparticle-polymer interfaces that effectively convert atmospheric humidity fluctuations into precise electrical signals, the system pioneers a contactless and non-invasive paradigm in assistive speech technology. This innovation addresses limitations of existing devices, such as reliance on residual vocal fold vibrations or skin-contact sensors, offering a practical generalized solution for individuals with aphonia. With its potential to facilitate naturalistic communication and transform healthcare applications, the HSRM system sets a new benchmark in wearable assistive technologies for voice rehabilitation and human-machine interaction.}, archive = {J_ADVS}, author = {Jianfei Wang and Hongyu Zhang and Xiaomin Wu and Mingyan Gao and He Wen and Zhibo Zhang and Kremena Makasheva and Wen Jung Li and Zuobin Wang}, doi = {10.1002/advs.202504343}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e04343}, shortjournal = {Adv. Sci.}, title = {A wearable AI-driven mask with humidity-sensing respiratory microphone for non-vocal communication}, volume = {12}, year = {2025}, }
• (2025). GHSR-foxo1 signaling in macrophages promotes liver fibrosis via inflammatory response and hepatic stellate cell activation. ADVS, 12(33), e04223. (www)

  @article{ , abstract = {Liver fibrosis is a severe liver disease directly linked to chronic inflammation, in which hepatic macrophages play a key role. Growth hormone secretagogue receptor (GHSR) is the receptor of nutrient-sensing hormone ghrelin that has essential functions in metabolism, inflammation, and wound-healing. However, the role of GHSR in liver fibrosis is unknown. This study uses a carbon tetrachloride (CCl 4 )-induced liver fibrosis mouse model to investigate the role of macrophage GHSR in liver fibrosis. CCl 4 induces macrophage accumulation and inflammatory responses, noticeably increases GHSR expression in the liver. It is found that macrophage Ghsr deletion ( Ghsr-MϕKO ) attenuates CCl 4 -induced liver fibrosis and inflammation, showing reduced hepatic monocyte-derived macrophages (MDMs) and suppressed proinflammatory responses. In macrophages, transforming growth factor (TGF)-β1 expression is positively correlated with GHSR expression. GHSR-associated TGF-β1 in macrophages activates hepatic stellate cells (HSCs) by promoting the crosstalk between macrophages and HSCs. Macrophage GHSR controls inflammation and TGF-β1 expression via protein kinase A (PKA)-mediated Forkhead box protein O 1 (Foxo1) phosphorylation at S273; Foxo1-S273D mutation, mimicking constitutive phosphorylation of Foxo1 at S273, shows exacerbated CCl 4 -induced liver inflammation and fibrosis. Thus, targeting the macrophage GHSR−Foxo1 signaling may provide a new strategy to treat liver fibrosis.}, archive = {J_ADVS}, author = {Da Mi Kim and Quan Pan and Zeyu Liu and Weiqi Ai and Hye Won Han and Sakhila K. Banu and Robert Y.L. Tsai and Gus A. Wright and Shaodong Guo and Yuxiang Sun}, doi = {10.1002/advs.202504223}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e04223}, shortjournal = {Adv. Sci.}, title = {GHSR-foxo1 signaling in macrophages promotes liver fibrosis via inflammatory response and hepatic stellate cell activation}, volume = {12}, year = {2025}, }
• (2025). Fatigue limit doubling in high-strength martensitic steel through crack embryo Engineering–Cyclic-training-driven self-optimization. ADVS, 12(33), e04165. (www)

  @article{ , abstract = {Achieving superior fracture resistance under cyclic loading–specifically, a high-fatigue limit–is crucial for ensuring structural safety and supporting a sustainable society. This study demonstrates a breakthrough in overcoming the conventional fatigue limit ceiling in high-strength as-quenched martensitic steel by enhancing resistance to crack initiation. In the as-heat-treated state, high-angle boundaries with large elastic misfits and plastic incompatibility served as precursory sites for intrusions/extrusions (these are defined as “crack embryos”), eventually leading to fatigue crack initiation. Remarkably, after the pre-fatigue training, surface crack initiation is entirely suppressed, doubling the fatigue limit with minimal change in tensile strength. A novel concept of “crack embryo engineering” is introduced, which targets the prevention of crack embryo formation by extracting intrinsic microstructural self-optimization against fatigue deformation: macroscopic hardness homogenization and selective nano-hardening of the precursory sites. This self-optimization strategy offers a versatile approach to improving fatigue limit in general steels, providing an effective alternative to tempering heat treatment that inevitably sacrifices tensile strength.}, archive = {J_ADVS}, author = {Kazuho Okada and Kaneaki Tsuzaki and Eri Nakagawa and Akinobu Shibata}, doi = {10.1002/advs.202504165}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e04165}, shortjournal = {Adv. Sci.}, title = {Fatigue limit doubling in high-strength martensitic steel through crack embryo Engineering–Cyclic-training-driven self-optimization}, volume = {12}, year = {2025}, }
• (2025). A dynamic contrast-enhanced MRI-based vision transformer model for distinguishing HER2-zero, -low, and -positive expression in breast cancer and exploring model interpretability. ADVS, 12(33), e03925. (www)

  @article{ , abstract = {Novel antibody-drug conjugates highlight the benefits for breast cancer patients with low human epidermal growth factor receptor 2 (HER2) expression. This study aims to develop and validate a Vision Transformer (ViT) model based on dynamic contrast-enhanced MRI (DCE-MRI) to classify HER2-zero, -low, and -positive breast cancer patients and to explore its interpretability. The model is trained and validated on early enhancement MRI images from 708 patients in the FUSCC cohort and tested on 80 and 101 patients in the GFPH cohort and FHCMU cohort, respectively. The ViT model achieves AUCs of 0.80, 0.73, and 0.71 in distinguishing HER2-zero from HER2-low/positive tumors across the validation set of the FUSCC cohort and the two external cohorts. Furthermore, the model effectively classifies HER2-low and HER2-positive cases, with AUCs of 0.86, 0.80, and 0.79. Transcriptomics analysis identifies significant biological differences between HER2-low and HER2-positive patients, particularly in immune-related pathways, suggesting potential therapeutic targets. Additionally, Cox regression analysis demonstrates that the prediction score is an independent prognostic factor for overall survival (HR, 2.52; p = 0.007). These findings provide a non-invasive approach for accurately predicting HER2 expression, enabling more precise patient stratification to guide personalized treatment strategies. Further prospective studies are warranted to validate its clinical utility.}, archive = {J_ADVS}, author = {Xu Zhang and Yi-Yuan Shen and Guan-Hua Su and Yuan Guo and Ren-Cheng Zheng and Si-Yao Du and Si-Yi Chen and Yi Xiao and Zhi-Ming Shao and Li-Na Zhang and He Wang and Yi-Zhou Jiang and Ya-Jia Gu and Chao You}, doi = {10.1002/advs.202503925}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03925}, shortjournal = {Adv. Sci.}, title = {A dynamic contrast-enhanced MRI-based vision transformer model for distinguishing HER2-zero, -low, and -positive expression in breast cancer and exploring model interpretability}, volume = {12}, year = {2025}, }
• (2025). Near-infrared afterglow imaging-guided surgical resection and synergistic photodynamic-chemo therapy of breast cancer. ADVS, 12(33), e03883. (www)

  @article{ , abstract = {The recurrence rate of cancer following surgical procedures is markedly affected by the degree of tumor removal. During the operation, tumor-targeted imaging is of crucial significance as it assists surgeons in attaining the most comprehensive tumor excision. Herein, a theranostic platform (CDSP NPs) is developed through the assembly of carbon dots (CDs) with paclitaxel prodrugs. CDSP NPs can be utilized for near-infrared (NIR) afterglow imaging-guided precise removal of breast cancer, featuring a long lifetime (>2 h), deep tissue penetration (>13 mm), and a high signal-to-noise ratio (SNR, 103.9), thereby effectively preventing cancer recurrence. Additionally, the combined treatment of photodynamic therapy (PDT) and chemotherapy substantially enhances tumor regression, demonstrating the tremendous potential of CDSP NPs for synergistic cancer treatment. This study proposes a straightforward but efficient model to build a nanoplatform integrating diagnosis and treatment, which is utilized for image-guided surgical navigation and effective tumor treatment.}, archive = {J_ADVS}, author = {Zixuan Li and Ranran Zhao and Qing Pei and Zhigang Xie and Min Zheng}, doi = {10.1002/advs.202503883}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03883}, shortjournal = {Adv. Sci.}, title = {Near-infrared afterglow imaging-guided surgical resection and synergistic photodynamic-chemo therapy of breast cancer}, volume = {12}, year = {2025}, }
• (2025). Prompting interfacial elastic instability for effective and durable icephobic surfaces. ADVS, 12(33), e03855. (www)

  @article{ , abstract = {Icephobic surfaces offer a passive protection strategy against icing hazards in industrial applications. However, the improvement of surface icephobicity is normally accompanied by a compromise in mechanical properties and restrains the practical application of current icephobic surfaces/materials. Here, a generic strategy for icephobic material design is reported to address this conflict through interfacial elastic instability prompted by the synergistic integration of fibrous construction (FC) frameworks with icephobic polymers. The FC-based material structures could induce periodically localised/amplified stress at the ice/solid interface, leading to interfacial elastic instability and facilitating effective ice detachment. Low ice adhesion strength is achieved, while the tensile strength of the materials is enhanced by 19 times more than the polymer matrix due to the reinforcement from the FC frameworks. Based on the serrated features of the shear forces and numerically simulated interfacial stress distribution, a new theoretical model is established to interpret the nature of interfacial elastic instability and undulatory interfacial stress. This work provides fundamental insights for designing high-performance icephobic materials that transcend traditional performance trade-offs, advancing both surface science and materials for practical ice mitigation.}, archive = {J_ADVS}, author = {Xinyu Fan and Jingtong Li and Deyu Yang and Jie Fei and Hejun Li and Xianghui Hou}, doi = {10.1002/advs.202503855}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03855}, shortjournal = {Adv. Sci.}, title = {Prompting interfacial elastic instability for effective and durable icephobic surfaces}, volume = {12}, year = {2025}, }
• (2025). Cu7S4 nanozyme efficiently inactivating drug-resistant bacteria on mouse wound models through photodynamic and photothermal synergetic therapy. ADVS, 12(33), e03793. (www)

  @article{ , abstract = {The rapid emergence of drug-resistant bacteria has outpaced the development of traditional antibiotics, necessitating the exploration of more effective therapeutic strategies. In this study, the design of a Cu 7 S 4 multifunctional nanozyme, activated by near-infrared (NIR) light is presented, that demonstrates enhanced antibacterial activity. Cu 7 S 4 is synthesized with varying defect structures by utilizing different templates, which substantially optimize its absorption to H 2 O 2 and lipopolysaccharides (LPS) molecules. This process generates an optimal electronic structure, producing efficient antibacterial activity through photodynamic and photothermal synergetic processes. Specifically, the Cu 7 S 4 nanozyme with dual defects ( VCu and VCuCuCuSSS ) exhibits peroxidase-like (POD), catalase-like (CAT), and GSH-depletion properties, effectively inactivating drug-resistant bacteria such as Pseudomonas aeruginosa. Notably, in a mouse wound model infected with P. aeruginosa , the nanozyme demonstrates significant antibacterial efficacy, promoting wound healing under NIR light. This multifunctional Cu 7 S 4 nanozyme presents a promising new strategy for combating drug-resistant bacterial infections.}, archive = {J_ADVS}, author = {Xueya Li and Dazhen Liu and Song Han and Yujia Liu and Yuanyang Fan and Yu Zhang and Chunchang Li and Zhenshan Xia and Lingbing Cui and Jing Cui and Jinghong Wen and Tao Yan and Chuanjia Jiang and Yongxin Jin and Qian Ren and Mingyang Liu}, doi = {10.1002/advs.202503793}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03793}, shortjournal = {Adv. Sci.}, title = {Cu7S4 nanozyme efficiently inactivating drug-resistant bacteria on mouse wound models through photodynamic and photothermal synergetic therapy}, volume = {12}, year = {2025}, }
• (2025). Multi-region brain organoids integrating cerebral, mid-hindbrain, and endothelial systems. ADVS, 12(33), e03768. (www)

  @article{ , abstract = {Brain organoid technology has revolutionized the ability to model human neurodevelopment in vitro. However, current techniques remain limited by their reliance on simplified endothelial cell populations. Multi-Region Brain Organoids (MRBOs) are engineered that integrate cerebral, mid/hindbrain, and complex endothelial organoids into one structure. Unlike earlier approaches based on isolated Human Umbilical Vein Endothelial Cells, the endothelial organoids contain diverse vascular cell types, including progenitors, mature endothelial cells, pericytes, proliferating angiogenic cells, and stromal cells. The strategy employs sequential modulation of key developmental pathways to generate individual organoids, followed by optimized fusion conditions that maintain regional identities while supporting cellular integration. Single-nucleus RNA sequencing reveals that MRBOs develop discrete neural populations specific to each brain region alongside specialized endothelial populations that establish paracrine signaling networks. Integration analysis with human fetal brain data shows that MRBOs contribute to 80% of cellular clusters found in human fetal brain tissue (Carnegie stages 12–16). CellChat analysis identifies 13 previously uncharacterized endothelial-neural signaling interactions. Endothelial-derived factors are uncovered that support intermediate progenitor populations during hindbrain development, but not cerebral development, revealing a role for endothelial populations in regional brain patterning. This platform enables matching of multiple developmental regions while incorporating endothelial components, providing opportunities for studying neurodevelopmental disorders with disrupted neural-endothelial interactions.}, archive = {J_ADVS}, author = {Anannya Kshirsagar and Hayk Mnatsakanyan and Sai Kulkarni and John Guo and Kai Cheng and Luke Daniel Ofria and Oce Bohra and Ram Sagar and Vasiliki Mahairaki and Christian E Badr and Annie Kathuria}, doi = {10.1002/advs.202503768}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03768}, shortjournal = {Adv. Sci.}, title = {Multi-region brain organoids integrating cerebral, mid-hindbrain, and endothelial systems}, volume = {12}, year = {2025}, }
• (2025). Phytophthora disrupts plant immunity by manipulating nitric oxide homeostasis through GSNOR inhibition. ADVS, 12(33), e03633. (www)

  @article{ , abstract = {Nitric oxide (NO), a pivotal redox signaling molecule, coordinates plant development and immune responses through S -nitrosylation-mediated protein modification. While NO-dependent S -nitrosylation fine-tunes immune responses, whether pathogens hijack this process to subvert plant immunity remains unclear. Here it is shown that S -nitrosoglutathione reductase (GSNOR), which maintains NO homeostasis by degrading S -nitrosoglutathione (GSNO), positively regulates tomato resistance to Phytophthora capsici . Active-site mutations in GSNOR abolished its function in plant defense. Remarkably, GSNOR is manipulated by PcRD18, which is an RxLR effector of P. capsici that is involved in virulence of this oomycete pathogen. PcRD18 elevates the cellular NO content and S -nitrosylation levels by dually inhibiting GSNOR activity and promoting its autophagy-mediated degradation via enhanced ATG8c interaction. Structure analysis reveals critical PcRD18-GSNOR interaction interfaces and mutations in these sites of PcRD18 abolish its ability to interact with GSNOR, thereby blocking the effector's ability to elevate NO levels, suppress the reactive oxygen species (ROS) burst, and enhance virulence. GSNOR mutations disrupting PcRD18 binding produced a mutant form of GSNOR enhancing Phytophthora resistance. These findings unveil a pathogen strategy to subvert NO homeostasis through effector-mediated hijacking of GSNOR and suggest that engineering the host-pathogen interface to disrupt the interaction between GSNOR and PcRD18 will enhance crop disease resistance.}, archive = {J_ADVS}, author = {Tingting Li and Jing Kang and Haizhu Zhang and Lina Wang and Minghui Lu and Lin Cai and Jianming Li and Matthieu H. A. J. Joosten and Yu Du}, doi = {10.1002/advs.202503633}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03633}, shortjournal = {Adv. Sci.}, title = {Phytophthora disrupts plant immunity by manipulating nitric oxide homeostasis through GSNOR inhibition}, volume = {12}, year = {2025}, }
• (2025). Convertible ROS Nanocatalyst/Eliminator for enhancing tumor radio-immunotherapy and relieving radiation enteritis. ADVS, 12(33), e03602. (www)

  @article{ , abstract = {Radiation-induced damage to normal tissue seriously disrupts the execution of radiotherapy (RT) and therefore attenuates its efficacy. Exploring new strategies to enhance the efficacy and reduce toxicity of RT has great clinical importance. Here, a PD-L1 affibody (Z PD-L1 ) grafted Janus Ag/Ag 2 S nanoarchitectures is developed as “reactive oxygen species lever” to enhance radiocatalysis and relieve radiation enteritis. The nanoplatform can achieve abundant energy deposition in the form of high-energy electrons within tumors upon X-ray exposure. Subsequently, the transfer of electrons from Ag 2 S to Ag moiety enables effective electron–hole pair separation, which greatly improves the radiocatalysis efficiency in generating highly toxic hydroxyl radical (•OH). Due to the specific binding to tumor PD-L1, Z PD-L1 endows this nanoplatform with efficient tumor targeting and meanwhile reduces immune suppression of T cells by achieving PD-1/PD-L1 blockade, intensifying RT-induced immunologic cell death. Notably, the presence of the Ag moiety allows the nanoplatform to act as an H 2 O 2 scavenger in intestinal tissues during metabolism, effectively relieving radiation enteritis. Moreover, systemic administration of the nanoplatform coupled with Mn-DOTA can guide RT timing selection by magnetic resonance imaging. Overall, this nanoplatform can substantially improve RT effectiveness with reduced radiation enteritis, demonstrating considerable potential in tumor RT.}, archive = {J_ADVS}, author = {Mengmeng Zhang and Xinyu Zhang and Chenyu Wang and Mengyao Mu and Ke Ren and Nengyi Ni and Li Xian Yip and Kai Guo and Xiaoyu Hu and Feifei Teng and David Tai Leong and Qing Fan and Xiao Sun}, doi = {10.1002/advs.202503602}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03602}, shortjournal = {Adv. Sci.}, title = {Convertible ROS Nanocatalyst/Eliminator for enhancing tumor radio-immunotherapy and relieving radiation enteritis}, volume = {12}, year = {2025}, }
• (2025). Color-filter-free image sensor using CsPbBr3 quantum-dot-based tamm plasmon photodetector for photonic synapse facial recognition. ADVS, 12(33), e03464. (www)

  @article{ , abstract = {This study demonstrates that optical absorption of the CsPbBr 3 quantum dots can be significantly enhanced through monolithic integration with the Tamm plasmon (TP) structure. This integration enables the resulting TP photodetector to achieve a higher photocurrent and a more linear power dependence compared to the reference device with a nonresonant configuration. The enhancement is confined to the designed resonant energy, while photons with off-resonance energies are fully reflected, making the TP photodetector an ideal candidate for compact and efficient image sensors, eliminating the need for additional filters or bulky microlenses for color discrimination or photon collection. Furthermore, the photocurrent generated by the TP photodetector can be regulated by varying light pulse stimulations, enabling it to mimic the synaptic dynamics of the human brain. By integrating the functions of perception, processing, and memorization of visual images, its potential for facial recognition through simulation based on a 64 × 64 array of TP photodetectors under the artificial neural network-based weight-update expectation thresholding model is demonstrated. These findings mark a significant step forward in utilizing all-inorganic perovskite materials for compact, color-filter-free image sensors and open new avenues for photonic neural computations on a single platform.}, archive = {J_ADVS}, author = {Meng-Cheng Yen and Yung-Chi Yao and Chia-Jung Lee and Shi-Hui Huang and Wei Jie Hong and Yuto Kajino and Hsu-Cheng Hsu and Min-Hsiung Shih and Gong-Ru Lin and Kaoru Tamada and Jinn-Kong Sheu and Ya-Ju Lee}, doi = {10.1002/advs.202503464}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03464}, shortjournal = {Adv. Sci.}, title = {Color-filter-free image sensor using CsPbBr3 quantum-dot-based tamm plasmon photodetector for photonic synapse facial recognition}, volume = {12}, year = {2025}, }
• (2025). Stacking interventions enhances carbon removals and profitability of livestock production systems. ADVS, 12(33), e03382. (www)

  @article{ , abstract = {While previous studies have primarily examined the impacts of singular interventions on GHG emissions reduction and carbon dioxide removals (CDR), few studies explore complementarities and antagonisms when multiple interventions are simultaneously operationalized. Here, the aim is to examine how stacking of two pathways for mitigation–CDR, via soil organic carbon (SOC) accrual and GHG emissions avoidance via antimethanogenic feed additives–impacts net GHG emissions associated with sheep production. A nonlinear programing approach is invoked to elicit optimal combinations of grazing management and antimethanogenic feed additives to maximize farm profit and/or minimize net GHG emissions. It is shown that stacking multiple interventions realizes that greater abatement and profit do any singular intervention. Adoption of 3-NOP feed supplement with 15- and 30-paddock high stocking rate systems is the most prospective stacked intervention for concurrent profit maximization and emissions minimization. It is contended that (1) increasing payments for farming of carbon and ecosystems services relative to that of wool and meat will stimulate participation in carbon markets, (2) economics of participation in carbon markets tend to be more favorable for larger farms than smaller farms due to economies of scale and (3) adoption of optimal grazing management and antimethanogenic feed additives can realize more profit from sheep production and carbon farming than enterprises that only derive income from sheep production.}, archive = {J_ADVS}, author = {My Pham-Kieu and Stephen Ives and Warwick Badgery and Matthew Tom Harrison}, doi = {10.1002/advs.202503382}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03382}, shortjournal = {Adv. Sci.}, title = {Stacking interventions enhances carbon removals and profitability of livestock production systems}, volume = {12}, year = {2025}, }
• (2025). Podocyte RIPK3 deletion improves diabetic kidney disease by attenuating NF-κB p65 driven inflammation. ADVS, 12(33), e03325. (www)

  @article{ , abstract = {Receptor-interacting protein kinase 3 (RIPK3) is a key player in necroptosis and an emerging inflammation regulator, whose contribution to podocyte injury in diabetic kidney disease (DKD) remain unclear. Here, podocyte-specific RIPK3-knockout (KO) DKD mice and high glucose (HG) cultured mouse podocytes are used to elucidate the protective effects of podocyte RIPK3 deletion on DKD, explore the molecular pathogenic mechanisms of RIPK3 in podocyte injury, and assess pharmacological inhibition of RIPK3 signaling as a therapeutic strategy. The results demonstrated that podocyte-specific RIPK3-KO alleviated albuminuria, mesangial matrix proliferation, foot process fusion, and podocyte loss in DKD mice. Additionally, podocyte RIPK3 is upregulated in renal biopsies with DKD and expression is negatively correlated with albuminuria. In vitro, knockdown of RIPK3 using small interfering RNA (siRNA) or inhibition with GSK'872 prevented podocyte injury. RNA sequencing of mouse podocytes revealed that the knockdown of RIPK3 can alleviate HG-induced activation of the NF-κB-related inflammatory pathways. Importantly, pharmacological inhibition of RIPK3 by GSK'872 alleviated podocyte damage, and reduced proteinuria in DKD mice. Overall, these results uncovered a novel role of podocyte RIPK3 in promoting podocyte injury and DKD progression by regulating NF-κB-mediated inflammatory signaling independent of necroptosis, offering novel insights and potential therapeutic strategies for DKD management.}, archive = {J_ADVS}, author = {Lu'an Li and Jiaying Li and Ruizhao Li and Xingchen Zhao and Yuanhan Chen and Yating Cai and Yan Yang and Weiteng Wang and Siqi Zheng and Li Zhang and Xinling Liang}, doi = {10.1002/advs.202503325}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03325}, shortjournal = {Adv. Sci.}, title = {Podocyte RIPK3 deletion improves diabetic kidney disease by attenuating NF-κB p65 driven inflammation}, volume = {12}, year = {2025}, }
• (2025). Splicing shift of RAC1 accelerates tumorigenesis and defines a potent therapeutic target in lung cancer. ADVS, 12(33), e03322. (www)

  @article{ , abstract = {Dysregulated RNA splicing has emerged as a pervasive yet understudied feature of cancer. The small GTPase RAC1 undergoes splicing changes in multiple cancers. However, the in vivo functional disparities between the two major RAC1 isoforms, RAC1B and the canonical RAC1A, and their therapeutic implications in cancer remain largely unexplored. Here, RAC1B is found to be significantly upregulated in lung adenocarcinoma (LUAD) patients, particularly in those harboring EGFR mutations. Through isoform-specific overexpression and depletion assays in murine and cellular models of EGFR -mutant LUAD, it is revealed that RAC1B, but not RAC1A, promotes LUAD cell proliferation and tumor growth. Mechanistically, RAC1B stabilizes EGFR by inhibiting its lysosome trafficking and degradation. This function is mediated by the specific binding of RAC1B to the guanine nucleotide exchange factor GDS1, which activates RAC1B. The splicing factor RBM10 which is frequently mutated in LUAD is further identified as a negative regulator of RAC1B . Importantly, utilizing LUAD patient-derived organoid and xenograft models, it is demonstrated that targeting RAC1B potently suppresses tumor growth and enhances the efficacy of EGFR inhibitors. Together, the findings delineate functional differences and underlying mechanisms of RAC1 isoforms in LUAD tumorigenesis, highlighting a promising therapeutic route via targeting RAC1B for lung cancer.}, archive = {J_ADVS}, author = {Yueren Yan and Ning Wang and Bowen Xing and Min Yang and Jun Shang and Yufang Bao and Lixing Xiao and Ningxia Zhang and Yunpeng Ren and Chunnan Liu and Yuting Chen and Han Han and Yunjian Pan and Lei Lv and Wei-Xing Zong and Hongbin Ji and Changyou Zhan and Zefeng Wang and Haiquan Chen and Yongbo Wang}, doi = {10.1002/advs.202503322}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03322}, shortjournal = {Adv. Sci.}, title = {Splicing shift of RAC1 accelerates tumorigenesis and defines a potent therapeutic target in lung cancer}, volume = {12}, year = {2025}, }
• (2025). In situ valence engineering of copper silicate nanozymes with enhanced peroxidase-like catalytic activity for oral disease detection. ADVS, 12(33), e03237. (www)

  @article{ , abstract = {As a series of attractive nanomaterials, nanozymes with great catalytic activity and specificity are well developed in the field of biosensors. Although promising, the lack of appropriate structural design strategy and limitation of sensing performance in the clinical samples remain challenging for the practical application of nanozymes. Herein, a novel copper silicate nanozyme (CSHSs-Ar) with enhanced peroxidase-like catalytic activity is synthesized through a facile in situ valence-engineered approach. After the optimization of synthesis, the resultant CSHSs-Ar nanozymes containing nearly 60% of Cu + hold a higher peroxidase-like catalytic activity and a better catalytic specificity than the other two derivatives (CSHSs and CSHSs-air). Theoretical calculations also demonstrate that CSHSs-Ar nanozymes are more beneficial toward the activation of H 2 O 2 compared with CSHSs and CSHSs-air. On this basis, the well-developed CSHSs-Ar nanozyme-involved system is employed as an efficient colorimetric sensor for the detection of volatile sulfur compounds (VSCs) and prediction for periodontitis. Moreover, several visual molecular logic gates are explored as a proof of concept to the application of CSHSs-Ar nanozymes with superior peroxidase-like catalytic activity. This study not only provides guidance for the development of novel nanozymes, but also broadens the biomedical application potential of nanozymes including the detection of oral diseases.}, archive = {J_ADVS}, author = {Xiaocan Liu and Zhen Ding and Chengjing Xu and Jinming Zhang and Yufu Liu and Tianyan Chen and Shuang Dai and Xingfu Bao and Min Hu and Zhen Liu}, doi = {10.1002/advs.202503237}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03237}, shortjournal = {Adv. Sci.}, title = {In situ valence engineering of copper silicate nanozymes with enhanced peroxidase-like catalytic activity for oral disease detection}, volume = {12}, year = {2025}, }
• (2025). Local visible-photocatalytic production of hydrogen and warm heat for combination treatment of pressure ulcer. ADVS, 12(33), e03185. (www)

  @article{ , abstract = {Pressure ulcer (PU) is hardly cured due to repeated pressures-induced serious ischemia-reperfusion injury (IRI), poor microcirculation, and chronical inflammation. Hydrogen molecule (H 2 ) is proved as an emerging anti-inflammatory and anti-IRI agent with high biological safety, while local warm heating is well identified and able to improve tissue microcirculation for promoting wound repair. This work proposes a new strategy of visible-photocatalytic hydrogen/warm heat production for combination treatment of PU, and develops palladium nanodots-deposited hydrogen-doped titanium dioxide nanorod (HTON-Pd) as a novel multifunctional photocatalyst, achieving controllable and sustainable visible-photocatalytic production of H 2 and heat. Daily administration of the HTON-Pd encapsulated hydrogel dressing (HTON-Pd@Gel) with the assistance of visible light irradiation receives a high outcome of PU treatment. The stubborn PU wound has completely been cured after 11-day treatment with HTON-Pd@Gel. Mechanistically, hydrogen and warm heat photocatalytically produced by HTON-Pd improve the PU wound microenvironment by synergistically promoting the proliferation and migration of skin cells, inhibiting their apoptosis, reducing the inflammatory response, and boosting the generation of new blood vessels in support of PU wound healing.}, archive = {J_ADVS}, author = {Jiawei Zhu and Ting Chen and Wei Fang and Di Zhou and Dalong Ni and Bin Zhao and Yali Yang and Zhuobin Xu and Qianjun He}, doi = {10.1002/advs.202503185}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03185}, shortjournal = {Adv. Sci.}, title = {Local visible-photocatalytic production of hydrogen and warm heat for combination treatment of pressure ulcer}, volume = {12}, year = {2025}, }
• (2025). The role of HINT3 in myocardial ischemia-reperfusion injury in male mice: Mechanisms involving SDHA and its acetylation. ADVS, 12(33), e03109. (www)

  @article{ , abstract = {Myocardial ischemia-reperfusion (I/R) injury is characterized by oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis. During I/R, the accumulation and oxidation of succinate contribute to reactive oxygen species (ROS) production, worsening tissue damage. Histidine triad nucleotide-binding protein 3 (HINT3) is identified as a regulator of mitochondrial function and cardiomyocyte survival during I/R. In a mouse I/R model and an oxygen-glucose deprivation/reoxygenation (OGD/R) model, it shows that HINT3 expression is downregulated after I/R. Cardiomyocyte-specific knockout of HINT3 exacerbates myocardial injury, impairs cardiac function, and promotes mitochondrial dysfunction and apoptosis, whereas HINT3 overexpression mitigates these effects. Mechanistically, HINT3 interacts with succinate dehydrogenase subunit A (SDHA), suppresses HDAC1 expression, and prevents SDHA deacetylation at K335, reducing SDH activity and mitochondrial ROS production. These findings highlight the HINT3-HDAC1-SDHA axis as a key pathway in mitochondrial regulation, offering new insights and therapeutic targets for myocardial reperfusion injury.}, archive = {J_ADVS}, author = {Jiabin Yu and Qi Yao and Tongtong Hu and Yadan Zhang and Ying Liu and Yang Xiao and Qingqing Wu and Qizhu Tang}, doi = {10.1002/advs.202503109}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03109}, shortjournal = {Adv. Sci.}, title = {The role of HINT3 in myocardial ischemia-reperfusion injury in male mice: Mechanisms involving SDHA and its acetylation}, volume = {12}, year = {2025}, }
• (2025). TRF-5004b enriched secretory autophagosomes induce endothelial cell activation to drive acute respiratory distress syndrome. ADVS, 12(33), e03014. (www)

  @article{ , abstract = {Acute respiratory distress syndrome (ARDS) is an acute inflammatory lung injury for which effective therapeutic agents are lacking. Excessive endothelial cell (EC) activation is a critical trigger of inflammation. Extracellular vesicles (EVs) are increasingly recognized as prominent regulators of inflammatory responses. The previous study identified secretory autophagosomes (SAPs), a novel class of EVs, as a prognostic marker in ARDS, raising questions of whether and how they are involved in the pathogenesis of ARDS. Here, it is shown that inflamed macrophage-derived SAPs (MSAPs) exacerbate lung injury by weakening the role of ECs as gatekeepers of immune cell transport within the lung. Bioinformatics and functional studies reveal that tRF-5004b is a key molecule of MSAPs in mediating endothelial activation. Mechanically, tRF-5004b directly interacts with the nuclear transporter KPNA2, thereby facilitating the association between KPNA2 and the transcription factor p65. This interaction enhances p65 nuclear translocation, a process implicated in EC activation. Additionally, the level of tRF-5004b is positively correlated with the severity of ARDS, and patients with high tRF-5004b levels have a poor prognosis. Overall, it is found that tRF-5004b-enriched SAPs induce acute lung injury by promoting p65 nuclear translocation to activate ECs, suggesting that tRF-5004b may be a novel therapeutic target for ARDS.}, archive = {J_ADVS}, author = {Xing-xing Zhu and Han Li and Shuang-feng Zi and Ying Tang and Na Liu and Ke-xin Li and Shi-ke Geng and Hui-qing Lu and Zhi-kang Xie and Xin-yi Xu and Yi-ting Wei and Li-xin Wang and Tao Liu and Jie Chao and Yi Yang and Hai-bo Qiu and Wei Huang and Ling Liu}, doi = {10.1002/advs.202503014}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e03014}, shortjournal = {Adv. Sci.}, title = {TRF-5004b enriched secretory autophagosomes induce endothelial cell activation to drive acute respiratory distress syndrome}, volume = {12}, year = {2025}, }
• (2025). Deciphering cell type abundance in proteomics data through graph neural networks. ADVS, 12(33), e02987. (www)

  @article{ , abstract = {Recent advancements in proteomics sequencing have significantly enhanced our ability to explore cell-type-specific signatures within complex tissues, providing critical insights into disease mechanisms. However, current proteomic technologies often suffer from low resolution, resulting in the mixing of multiple cell types during profiling. To address this limitation, cell-type deconvolution methods are developed to infer cellular composition from proteomic data. While most existing deconvolution methods are focused on transcriptomics, their application to proteomics is hindered by the weak correlation and divergent quantification between transcriptome and proteome data. Although a few proteomic-specific deconvolution methods are recently emerged, they still exhibit limited capability and performance, partly because they only extract shared information from individual samples while ignoring higher-order relationships between them. Here, GraphDEC is proposed, a novel graph neural network-based method for dec iphering cell type proportions in proteomic profiling data. GraphDEC begins by simulating bulk samples from single-cell proteomic data to create reference data, which is then used to infer cell types in target datasets. Specifically, GraphDEC employs an autoencoder to extract low-dimensional representations from both reference and target proteomic data, enabling the construction of similarity relationships among samples. These relationships, combined with proteomic data, are processed by a graph neural network that integrates a multi-channel mechanism and a hybrid neighborhood-aware approach to learn highly effective representations. To optimize the model, GraphDEC utilizes multiple loss functions, including triplet loss, domain adaptation loss, and Mean Squared Error (MSE) loss, ensuring robust performance and mitigating batch effects. Benchmark experiments demonstrate that GraphDEC achieves state-of-the-art performance across diverse synthetic proteomic datasets from different sequencing technologies and real-world spatial proteomic datasets. Furthermore, GraphDEC exhibits strong generalization capabilities, showing high efficiency when applied to cross-species proteomic data and even transcriptomics.}, archive = {J_ADVS}, author = {Zhiming Dai and Yujie Song and Tuoshi Qi and Hongyu Zhang and Huiying Zhao and Zheng Wang and Yuedong Yang and Yuansong Zeng}, doi = {10.1002/advs.202502987}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02987}, shortjournal = {Adv. Sci.}, title = {Deciphering cell type abundance in proteomics data through graph neural networks}, volume = {12}, year = {2025}, }
• (2025). Red blood cell membrane lipidomics: Potential biomarkers detecting method for plasma volume overload and major adverse cardiovascular events in chronic heart failure patients. ADVS, 12(33), e02893. (www)

  @article{ , abstract = {Plasma volume fluctuations limit the utility of circulating lipidomics in chronic heart failure (CHF). In contrast, red blood cell (RBC) membrane lipidomics may serve as stable biomarkers that are unaffected by plasma volume changes. Two cohorts are included to investigate the association between RBC indicators and CHF. RBC membrane lipidomics is first used to characterize CHF and its impact on plasma volume overload (PVO) and major adverse cardiovascular events (MACE). The first cohort (n = 507,638) shows that the erythrocyte stress index (ESI), better than traditional RBC indicators, is associated with the prevalence of CHF with odds ratio (OR) and confidence interval (CI) of 1.57 (95% CI,1.55-1.59). ESI is also linked with in-hospital death in CHF. Another cohort (n = 1,550) indicated RBC membrane lipidomics ceramide subtype Cer 18:0;O2/16:0 and lysophosphatidylethanolamine subtype LPE 18:0 has an AUC of PVO with 0.75 and 0.61. The above two lipids are risk factors of PVO with OR of 1.62 (95% CI, 1.47-1.80) and 1.11 (95% CI, 1.06-1.16). They also are risk factors for MACE, with hazard ratios (HR) of 1.04 (95% CI, 1.01-1.07) and 1.06 (95% CI, 1.01-1.10). This research emphasizes the potential value of RBC membrane lipidomics for CHF development, prognosis, and treatment.}, archive = {J_ADVS}, author = {Lin Zhang and Xiangqin Ou and Jingyi Lin and Xiaofei Luo and Jiashun Zhou and Xingyue Zhou and Peihua Zhao and Li Liu and Ziran Zhao and Ying Zhou and Guanwei Fan and Lifeng Han and Xiumei Gao}, doi = {10.1002/advs.202502893}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02893}, shortjournal = {Adv. Sci.}, title = {Red blood cell membrane lipidomics: Potential biomarkers detecting method for plasma volume overload and major adverse cardiovascular events in chronic heart failure patients}, volume = {12}, year = {2025}, }
• (2025). Wearable bioelectronics for home-based monitoring and treatment of muscle atrophy. ADVS, 12(33), e02831. (www)

  @article{ , abstract = {Muscle atrophy is a chronic disease caused by multiple factors, and there is currently no effective treatment or reliable diagnostic method. Similar review articles focus on the induction and summary of the pathogenic mechanism and traditional treatment of muscle atrophy. However, soft, portable, and efficient bioelectronic devices that are expected to achieve home diagnosis and treatment of the disease are more concerned, hoping to realize complete home care as soon as possible. The article includes: 1) Classification and summary of muscle atrophy-related diseases and pathways; 2) Mechanical sensors, electromyography (EMG), electrochemical sensors, bioelectrical impedance analysis (BIA), and ultrasonic patches for monitoring muscle atrophy; 3) Transcutaneous electrotherapy, bioelectronic implants, bioelectronic drug delivery devices, and ExoMuscles for treating muscle atrophy; 4) Electrode–tissue interface problems in muscle atrophy bioelectronics and feasible solutions. 5) Recommendations and prospects for integrated bioelectronic systems for home diagnosis and treatment of muscle atrophy in the future.}, archive = {J_ADVS}, author = {Shuai Zhang and Renjie Tan and Shuo Meng and Ke Zhang and Jinlian Hu}, doi = {10.1002/advs.202502831}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02831}, shortjournal = {Adv. Sci.}, title = {Wearable bioelectronics for home-based monitoring and treatment of muscle atrophy}, volume = {12}, year = {2025}, }
• (2025). Clinical features, molecular biology, and the metastatic microenvironment in lung cancer brain metastases: Implications for treatment decisions. ADVS, 12(33), e02626. (www)

  @article{ , abstract = {Brain metastases (BM) represent a highly aggressive, clinically distinct subtype of lung cancer, often associated with poor prognosis. Historically, treatment options for BM have been limited and largely nonspecific. However, recent advancements in clinical and preclinical research have led to substantial improvements in patient outcomes. This review focuses on BM arising from lung cancer, providing an overview of recent findings related to clinical characteristics, diagnostic strategies, and early metastatic processes. Multi-omics analyses have elucidated the molecular mechanisms underlying tumor initiation and progression, with particular emphasis on the role of the tumor microenvironment. In this review, preclinical BM models, detailed signaling pathways, and emerging clinical therapies are also discussed. Current treatment approaches are multidisciplinary, and multi-omics technologies enhance both diagnosis and therapeutic strategies by revealing the complex biology of BM. Continued research is needed to identify BM-specific drug targets, particularly those involved in crossing the blood–brain barrier and remodeling the brain microenvironment. Addressing these challenges is crucial for improving clinical outcomes in patients with BM.}, archive = {J_ADVS}, author = {Yixiang Zhu and Danming He and Zan Hou and Mei Lan and Ye Zhang and Qifeng Wang}, doi = {10.1002/advs.202502626}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02626}, shortjournal = {Adv. Sci.}, title = {Clinical features, molecular biology, and the metastatic microenvironment in lung cancer brain metastases: Implications for treatment decisions}, volume = {12}, year = {2025}, }
• (2025). Near room-temperature ferromagnetic phase achieved in 4d ruthenate via interfacial ferrimagnetic coupling and octahedral rotation engineering. ADVS, 12(33), e02613. (www)

  @article{ , abstract = {Transition metal oxides (TMOs) simultaneously possessing strong spin-orbit coupling, near room-temperature ferromagnetism, and excellent conductivity are scarce while they show great potential applications in oxide spintronics. Here, a TMO with all these features is reported, existing as an interfacial phase in the 4 d Ca 0.5 Sr 0.5 RuO 3 layer sandwiched by two LaMnO 3 layers. This phase is well conductive and ferromagnetic in a wide temperature range, with the highest Curie temperature of ≈275 K among the 4 d /5 d -TMOs. Particularly, this interfacial phase shows a considerably improved saturation magnetization (≈2 µ B /Ru, twice that of the bulk counterpart), and a greatly reduced coercive force. All these features are highly desired by the application of spin-orbit torque. Due to the presence of strong spin-orbit coupling, such a Ca 0.5 Sr 0.5 RuO 3 interfacial phase exhibits a significantly larger anomalous Hall conductivity than the typical 3 d oxide ferromagnet La 2/3 Sr 1/3 MnO 3 near room temperature. Analyses based on the techniques of X-ray magnetic circular dichroism, polarized-neutron reflectometry, and scanning transmission electron microscopy reveal a magnetic exchange interaction between the interfacial phases of Ca 0.5 Sr 0.5 RuO 3 and LaMnO 3 and an obvious expansion of the interfacial Mn─O─Mn bond angle, stabilizing the high-temperature ferromagnetic state of the CSRO/LMO interface.}, archive = {J_ADVS}, author = {Mengqin Wang and Qinghua Zhang and Xiao Deng and Jie Zheng and Wenxiao Shi and Yunzhong Chen and Baogen Shen and Yuansha Chen and Tao Zhu and Fengxia Hu and Jirong Sun}, doi = {10.1002/advs.202502613}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02613}, shortjournal = {Adv. Sci.}, title = {Near room-temperature ferromagnetic phase achieved in 4d ruthenate via interfacial ferrimagnetic coupling and octahedral rotation engineering}, volume = {12}, year = {2025}, }
• (2025). Engineered cas12j-8 is a versatile platform for multiplexed genome modulation in mammalian cells. ADVS, 12(33), e02593. (www)

  @article{ , abstract = {Cas12j-8 is a compact Cas nuclease discovered from the metagenome of giant bacteriophages, consisting of only 717 amino acids and recognizing the ‘5-TTN-3′ protospacer adjacent motif (PAM) sequence. However, its low gene editing efficiency in mammalian cells limits its application in therapeutic gene editing. To address this limitation, structure-guided mutagenesis is employed to replace key negatively charged residues with arginine, strengthening DNA binding. The resulting quintuple mutant, engineered Cas12j-8 (enCas12j-8), demonstrates robust on-target editing efficiency comparable to LbCas12a while maintaining low off-target effects. Cytosine base editors (CBEs) and adenine base editors (ABEs) are developed using enCas12j-8, achieving up to 29.54-fold C-to-T and 36.57-fold A-to-G conversion efficiency compared with the wild-type at the dominated sites, respectively. Notably, enCas12j-8 enables multiplexed editing of three genomic loci simultaneously via a single crRNA array, achieving efficiencies comparable to single-guide approaches. Additionally, enCas12j-8-ABE facilitates the disruption of splice acceptor sites, effectively inducing exon skipping in the SOD1 gene. This strategy holds potential significance for therapeutic genome modulation. These findings establish enCas12j-8 as a versatile, high-precision tool for genome engineering, combining efficient delivery, multiplexing capability, and compatibility with diverse editing modalities.}, archive = {J_ADVS}, author = {Ru Meng and Jiayao Li and Wuke Wang and Dong Liang and Zhanwei Li and Cong Mao and Qingyang Li and Yu Zhang and Hao Chen and Jin Tang and Ping Hu and Qi Niu and Xingxu Huang and Bin Shen and Jun Zhang}, doi = {10.1002/advs.202502593}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02593}, shortjournal = {Adv. Sci.}, title = {Engineered cas12j-8 is a versatile platform for multiplexed genome modulation in mammalian cells}, volume = {12}, year = {2025}, }
• (2025). Fabrication of site-specific 3D structures via macroscopic supramolecular assembly for spatially controlled alignment of multiple cells. ADVS, 12(33), e02425. (www)

  @article{ , abstract = {The self-assembly of micrometer-to-millimeter components, referred to as “macroscopic supramolecular assembly (MSA),” offers an efficient approach for constructing cell-scale 3D bioactive structures with flexible modular designs. Compared with available 3D bio-printing or conventional modular assembly of cell-material units, MSA is advantageous in decoupling material preparation and cell loading processes by directing cell adhesion after the preparation of 3D structures, which minimizes the trade-off between cell viability and material selection. But the challenge lies in efficient self-sorting of different cells and spatially controlled cell distribution. Hence, MSA is combined with the surface chemistry of orthogonally specific peptides to different cells and magnetic manipulation, and fabricated 3D bioactive structures that direct cell sorting. Microscale polydimethylsiloxane (PDMS) components are modified with 1) Arg-Glu-Asp-Val and Val-Ala-Pro-Gly peptides affinitive to endothelial cells (ECs) and smooth muscle cells (SMCs), respectively, and 2) host/guest molecules as “supramolecular glues” for precise structuring and interfacial bonding. Self-sorting and spatially controlled adhesion of ECs and SMCs is achieved to mimic layered vascular structures. This “Lego-like” strategy is free of compromising cell viability with structure design, thus contributing to spatially intricate and bioactive 3D architectures, and promoting the development of MSA from fundamental advances to applications.}, archive = {J_ADVS}, author = {Yuchen Liu and Rui Ming and Qian Zhang and Yuguang Wang and Yijing Liu and Yuriy G. Galyametdinov and Andrey Knyazev and Feng Shi and Fang Liu and Mengjiao Cheng}, doi = {10.1002/advs.202502425}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02425}, shortjournal = {Adv. Sci.}, title = {Fabrication of site-specific 3D structures via macroscopic supramolecular assembly for spatially controlled alignment of multiple cells}, volume = {12}, year = {2025}, }
• (2025). Brain-inspired polymer dendrite networks for morphology-dependent computing hardware. ADVS, 12(33), e02291. (www)

  @article{ , abstract = {Process variation is always a challenge to mitigate in electronics. This especially holds true for organic semiconductors, where reproducibility concerns hinder industrialization. Challenging this concept, it shows AC-electropolymerization to be a powerful platform for the development of morphology-dependent computing hardware, thanks precisely to its intrinsic stochasticity. The findings reveal that electropolymerized polymer dendrite networks exhibit a complex structure-operation relationship that allows to implement nearly linear to nonlinear functions. Moreover, dendritic networks can integrate a limitless number of inputs from their environment, which can be used to the advantage in the context of in materio computing to discriminate between different spatiotemporal inputs. These results position electropolymerization as a pivotal technique for the bottom-up implementation of computationally powerful objects. This study anticipates this study to help shifting the negative perception of variability in the material science community and promote the electropolymerization framework as a foundation for the development of a new generation of hardware defined by its topological richness.}, archive = {J_ADVS}, author = {Corentin Scholaert and Yannick Coffinier and Sébastien Pecqueur and Fabien Alibart}, doi = {10.1002/advs.202502291}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02291}, shortjournal = {Adv. Sci.}, title = {Brain-inspired polymer dendrite networks for morphology-dependent computing hardware}, volume = {12}, year = {2025}, }
• (2025). Dopamine d1 receptor contributes to glucocorticoid-associated osteonecrosis of femoral head protection through the ATF3/CHOP axis to inhibit osteoblastic apoptosis. ADVS, 12(33), e02276. (www)

  @article{ , abstract = {The nervous system plays a pivotal regulatory role in the maintenance of bone homeostasis, and the protective effects of dopamine and its receptors on bone metabolism are emerging. Despite these protective roles, the functional contribution of dopaminergic signaling, particularly through specific receptor subtypes, remains unexplored in glucocorticoid (GC)-associated osteonecrosis of the femoral head (ONFH) pathogenesis. Here, the dopamine D1 receptor (DRD1), a G protein-coupled receptor with few identified bone-related functions, is identified as a positive regulator of GC-induced apoptosis. The dopamine levels in the serum of GC-associated ONFH patients are significantly lower than those in the normal population. The protein and gene expression levels of DRD1 and the number of DRD1-positive cells are abnormally elevated in the pathological state of GC-associated ONFH, and DRD1 is expressed in osteoblasts. Overexpression of DRD1 attenuates GC-induced osteogenic inhibition and apoptosis in vivo and in vitro. Mechanistically, overexpression of DRD1 elevates cAMP levels, activates downstream protein kinase A, and inhibits GC-induced endoplasmic reticulum stress and apoptosis through the ATF3/CHOP signaling pathway, thus improving bone homeostasis. Importantly, Madopar, an FDA-approved dopaminergic agent, inhibits GC-induced osteoblastic apoptosis and ONFH via DRD1. Collectively, this study not only deciphers a previously unrecognized DRD1-mediated neuro-osteogenic axis but also repurposes an FDA-approved drug (Madopar) for precision ONFH management.}, archive = {J_ADVS}, author = {Kai Zheng and Wenming Li and Tianhao Wang and Gaoran Ge and Wei Zhang and Yi Qin and Wenhao Li and Zebin Wu and Zhen Wang and Gang Rui and Yaozeng Xu and Dechun Geng}, doi = {10.1002/advs.202502276}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02276}, shortjournal = {Adv. Sci.}, title = {Dopamine d1 receptor contributes to glucocorticoid-associated osteonecrosis of femoral head protection through the ATF3/CHOP axis to inhibit osteoblastic apoptosis}, volume = {12}, year = {2025}, }
• (2025). Targeting glutamine metabolism transporter SLC25A22 enhances CD8+ T-cell function and anti-PD-1 therapy efficacy in cervical squamous cell carcinoma: Integrated metabolomics, transcriptomics and T-cell-incorporated tumor organoid studies. ADVS, 12(33), e02225. (www)

  @article{ , abstract = {Cervical squamous cell carcinoma(CSCC) represents formidable challenge in clinical oncology, exacerbated by poor prognosis and resistance to current treatments, including anti-PD-1 therapy, highlighting the urgent need for alternative therapeuties. Metabolic characteristics have emerged as potential drivers of treatment resistance and immune evasion. Herein, 1) based on metabolomic and transcriptomic analyses of 44 CSCC and 18 normal tissues, glutamine-enriched and immunosuppressive microenvironment is identified in CSCC. 2) Integrative metabolomic and transcriptomic analyses revealed the glutamine metabolism transporter SLC25A22 as a key mediator in high glutamine metabolism, immune checkpoint activation and CD8+T-cell cytotoxicity. 3) Immunohistochemistry(IHC), multiplex IHC, and flow cytometry validation with clinical CSCC samples revealed not only increased SLC25A22, PD-1 expression and reduced CD8+T-cell cytotoxicity in CSCC but also increased SLC25A22 expression in high PD-L1 expressed CSCC patients, suggesting the potential of targeting SLC25A22 for enhancing CD8+T-cell cytotoxicity and improving anti-PD-1 efficacy, especially in high PD-L1 expressed patients. 4) Novelly, 3D-CSCC organoids are constructed, replicating parental tumor features, and 3D-T-cell-incorporated CSCC organoid models, replicating the interaction between tumor cells and CD8+T cells, for in vitro experiments. 5) Importantly, it is validated through in vitro 3D T-cell-incorporated CSCC organoid models and in vivo animal experiments that targeting the glutamine metabolism transporter SLC25A22, showed promise in enhancing CD8+T-cell cytotoxicity and sensitizing anti-PD-1 therapy. These findings provided insights for future clinical trials exploring metabolic modulation to improve immunotherapy responses in CSCC patients.}, archive = {J_ADVS}, author = {Tingting Ren and Junjun Qiu and Fanghua Chen and Qian Jiang and Qinqin Liu and Tong Wu and Hua Jiang and Keqin Hua}, doi = {10.1002/advs.202502225}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02225}, shortjournal = {Adv. Sci.}, title = {Targeting glutamine metabolism transporter SLC25A22 enhances CD8+ T-cell function and anti-PD-1 therapy efficacy in cervical squamous cell carcinoma: Integrated metabolomics, transcriptomics and T-cell-incorporated tumor organoid studies}, volume = {12}, year = {2025}, }
• (2025). A complementarity-based approach to de novo binder design. ADVS, 12(33), e02015. (www)

  @article{ , abstract = {De novo design of binders capable of targeting arbitrarily selected epitopes remains a substantial challenge. Here, a generalizable computational strategy is presented to design site-specific protein binders, obviating steps of extensive empirical optimization or in vitro screening. The dock-and-design pipeline retrieves complementary scaffolds from a protein structure database to a given query epitope, where the scaffold is mutated to carve a binding site de novo . The docking step utilizes a novel fingerprint that greatly simplifies and accelerates the surface complementarity evaluation. As proof-of-concept, we designed protein binders to target three distinct epitopes on two different oncogenic targets; vascular endothelial growth factor (VEGF) and interleukin-7 receptor-α (IL-7Rα). Experimental characterization of only 24 candidates identified nanomolar binders against each of the target epitopes, where the binders belonged to five different folds. Several designs were active in vitro. Moreover, anti-VEGF designs showed tumor-inhibiting activity in vivo, highlighting their therapeutic potential.}, archive = {J_ADVS}, author = {Kateryna Maksymenko and Valeriia Hatskovska and Murray Coles and Narges Aghaallaei and Natalia Pashkovskaia and Natalia Borbarán-Bravo and Matteo Pilz and Philip Bucher and Mareike Volz and Joana Pereira and Marcus D. Hartmann and Ghazaleh Tabatabai and Judith Feucht and Stefan Liebau and Patrick Müller and Andrei N. Lupas and Julia Skokowa and Mohammad ElGamacy}, doi = {10.1002/advs.202502015}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e02015}, shortjournal = {Adv. Sci.}, title = {A complementarity-based approach to de novo binder design}, volume = {12}, year = {2025}, }
• (2025). The GRK2/AP-1 signaling axis mediates vascular endothelial dysfunction and atherosclerosis induced by oscillatory low shear stress. ADVS, 12(33), e01981. (www)

  @article{ , abstract = {Disturbed blood flow and the resulting oscillatory low shear stress (OSS) are key contributors to vascular endothelial dysfunction and the initiation of atherosclerosis. However, the molecular mediators that translate abnormal hemodynamic signals into pathological vascular endothelial responses remain unclear. G protein-coupled receptors (GPCRs) are classical mechanosensors in the vascular endothelium. Here, using vascular endothelial-specific knockout mice, in vitro parallel plate flow chamber systems, and phosphoproteomic analysis, G protein-coupled receptor kinase 2 (GRK2) is identified as a central mediator of OSS-induced vascular endothelial dysfunction. Mechanistically, OSS promotes GRK2 phosphorylation at serine 29, which subsequently activates the transcription factor activator protein-1 (AP-1), increasing the expression of the proinflammatory adhesion molecules intercellular cell adhesion molecule-1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1). In parallel, AP-1 promotes nuclear receptor subfamily 4 group A 1 (NR4A1) transcription, which anchors liver kinase B1 (LKB1) to the nucleus and suppresses downstream AMP-activated protein kinase (AMPK) signaling, leading to metabolic dysregulation and impaired vascular endothelial homeostasis. These findings underscore the GRK2/AP-1 signaling axis as a crucial mechanotransduction cascade linking disturbed flow to vascular endothelial dysfunction. Given the important role of GPCRs in mechanotransduction, targeting GRK2 may offer a novel therapeutic approach for atherosclerosis.}, archive = {J_ADVS}, author = {Li-Da Wu and Yi Shi and Chao-Hua Kong and Ai-Qun Chen and Ying Kang and Jun-Yan Kan and Xiao-Min Jiang and Peng Chu and Dong-Chen Wang and Yi-Fei Lv and Zhi-Yuan Qian and Zi-Hao Jiang and Yun-Wei Chen and Yue Sun and Rui-Rui Chang and Wen-Ying Zhou and Yue Gu and Jun-Xia Zhang and Shao-Liang Chen}, doi = {10.1002/advs.202501981}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01981}, shortjournal = {Adv. Sci.}, title = {The GRK2/AP-1 signaling axis mediates vascular endothelial dysfunction and atherosclerosis induced by oscillatory low shear stress}, volume = {12}, year = {2025}, }
• (2025). Spontaneous strain-spin transition coupling molecular crystal with thermal magnetic memory effect, anisotropic high-κ and switchable dielectric permittivity. ADVS, 12(33), e01925. (www)

  @article{ , abstract = {Materials that exhibit controllable changes in electrical, magnetic, or spontaneous strain properties, particularly those that couple these functionalities simultaneously, hold significant potential for technological applications. In this study, a 1D phase transition ion-pair compound is investigated, triethylmethylammonium bis(1,2-maleonitriledithiolato)nickelate (abbr. [Et 3 MeN][Ni(mnt) 2 ], 1 ), composed of flexible Et 3 MeN + cation and planar radical [Ni(mnt) 2 ] − anion. This salt undergoes a paraelastic-ferroelastic phase transition at ≈233/224 K (on heating/cooling), driven by spin-lattice interactions. Importantly, the phase transition couples spontaneous strain, bistable magnetism with switchable dielectric properties. Another distinctive feature of 1 is its pronounced dielectric anisotropy and high dielectric permittivity, which arise due to a barrier layer capacitor effect due to cation displacement polarization and significant electron polarization of the highly conjugated anions. These findings provide a versatile molecular design strategy for developing magnetoelectric and mechanically multifunctional materials, with promising applications in next-generation electronic and smart devices that leverage coupled physical properties.}, archive = {J_ADVS}, author = {Xuan-Rong Chen and Zhang-Ni He and Yin Qian and Wei Wei and Zheng-Fang Tian and Xiao-Ming Ren}, doi = {10.1002/advs.202501925}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01925}, shortjournal = {Adv. Sci.}, title = {Spontaneous strain-spin transition coupling molecular crystal with thermal magnetic memory effect, anisotropic high-κ and switchable dielectric permittivity}, volume = {12}, year = {2025}, }
• (2025). Hydrogen-producing catalysts based on ferredoxin scaffolds. ADVS, 12(33), e01897. (www)

  @article{ , abstract = {Current attempts to transform our fossil fuel-based society into a sustainable one involve learning from and employing the biochemistry of nature. The process of photosynthesis is exemplary for utilizing sunlight as a regenerative energy source. Enzymes like hydrogenases, which reduce protons to molecular hydrogen (H 2 ) under ambient conditions, are model biocatalysts for generating sustainable, clean fuels. In green algae, photosynthesis and hydrogenases are coupled through ferredoxin, a small electron transfer protein. Here, it is shown that several plant-type ferredoxins can interact with a chemically synthesized active site cofactor analog of [FeFe]-hydrogenases in a way that allows comparably high H 2 evolution rates. UV–vis and Fourier-transform infrared spectroscopy indicate that the natural [2Fe-2S] clusters of the ferredoxin hosts must be absent for a functional interaction of polypeptide and cofactor mimic and that the apo-ferredoxins shield the H 2 -producing cofactor from the solvent. The hybrid proteins exhibited higher O 2 tolerance than natural [FeFe]-hydrogenases and generated H 2 in light-dependent cascades based on photosystem I or the chemical photosensitizer proflavine. These features and the combination of natural hosts and cofactors might contribute to establishing sustainable light-dependent H 2 production systems.}, archive = {J_ADVS}, author = {Yiting She and Vera Engelbrecht and Jacek Kozuch and Ulf-Peter Apfel and Sven T. Stripp and Anja Hemschemeier and Thomas Happe}, doi = {10.1002/advs.202501897}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01897}, shortjournal = {Adv. Sci.}, title = {Hydrogen-producing catalysts based on ferredoxin scaffolds}, volume = {12}, year = {2025}, }
• (2025). ε-poly-L-lysine-graft-oligo(3-hexylthiophene) copolymers as antibacterial and biodegradable polymer electronics. ADVS, 12(33), e01726. (www)

  @article{ , abstract = {Biodegradable polymer electronics offer an innovative solution to the growing challenge of electronic waste, which are engineered to disintegrate after a defined functional period. Here, a new class of graft copolymer is presented, ε-poly-L-lysine- graft -oligo(3-hexylthiophene) (EPL- g -O3HTs), synthesized by covalently grafting oligo(3-hexylthiophene) onto the biopolymer ε-poly-L-lysine at three grafting densities, resulting in copolymers containing 43, 65 and 90 wt.% O3HT (EPL- g -O3HT-1, EPL- g -O3HT-2 and EPL- g -O3HT-3, respectively). Benefiting from the “guidance” of ε-poly-L-lysine on O3HT chains alignment, the graft copolymer with optimized grafting density exhibits an extended conjugation length and increased crystallite size of O3HT. Thin films of three copolymers, upon doping, demonstrate appreciable conductivity under ambient conditions. EPL- g -O3HT-1 could be fully break down over 12 days by enzymatic degradation. EPL- g -O3HT-1 also displays excellent broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, attributed to its high ɛ-poly-L-lysine content. It is further demonstrated the versatility of EPL- g -O3HTs in transient electronics for electromyography sensors for muscle signal acquisition and as the channel material in organic electrochemical transistors. Combining tunable conductivity, controlled biodegradability, and antimicrobial properties, EPL- g -O3HT copolymers hold significant potential for diverse transient electronic applications, including skin and implantable electronics, where degradable electronics with antimicrobial properties are highly desirable.}, archive = {J_ADVS}, author = {Xin Sun and Eddie Wai Chi Chan and Fathumma Rizana Shiraz and Bicheng Zhu and Jingwen Yang and Katharina Matura and Viji Sarojini and Serpil Tekoglu and David Barker and Jadranka Travas-Sejdic}, doi = {10.1002/advs.202501726}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01726}, shortjournal = {Adv. Sci.}, title = {ε-poly-L-lysine-graft-oligo(3-hexylthiophene) copolymers as antibacterial and biodegradable polymer electronics}, volume = {12}, year = {2025}, }
• (2025). A MXene-based nanothermal knife inhibits aggresome-mediated persister formation for preventing dental caries. ADVS, 12(33), e01501. (www)

  @article{ , abstract = {Early childhood caries (ECC) is one of the most common chronic diseases among children globally, affecting the health and quality of life of children. Despite various treatments, cariogenic bacteria persist, resulting in a pessimistic outlook for the prevention and treatment of ECC. A notable presence of persister cells is found within the cariogenic bacterial population, with their dormancy enabling them to evade antiseptics. Mechanistically, the downregulation of heat shock proteins (HSPs) leads to protein aggresome formation, converting active cariogenic bacteria into persisters, which confers dual defensive barriers through metabolic inertness and concomitant reduction of membrane permeability, rendering conventional antimicrobials ineffective. Given these findings, Ti 3 C 2 MXene, a 2D nanomaterial acting as a “nanothermal knife” to disrupt persister cell membranes is developed. Ti 3 C 2 -mediated photothermal therapy (PTT) upregulated HSPs, inhibited aggresome formation, and prevented persister dormancy, showing efficacy against planktonic and biofilm cariogenic persisters. This PTT strategy demonstrates remarkable efficacy against planktonic cariogenic persisters and multispecies biofilms. Furthermore, the in vivo establishment of aggressive caries models reveals a substantial reduction of cariogenic pathogens following combined Ti 3 C 2 -mediated PTT and antimicrobial treatment, effectively suppressing caries progression. This light-assisted antibacterial strategy may aid ECC prevention.}, archive = {J_ADVS}, author = {Yinyin Zhang and Leilei Yang and Jing jiao and Wenshuai Li and Sen Lin and Xianlong Zong and Haoyang Qin and Danfeng Liu and Rui Li}, doi = {10.1002/advs.202501501}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01501}, shortjournal = {Adv. Sci.}, title = {A MXene-based nanothermal knife inhibits aggresome-mediated persister formation for preventing dental caries}, volume = {12}, year = {2025}, }
• (2025). Catalytic hairpin assembly-propelled weak-inputs-strong-outputs (CP-WISO) DNA logic nanodevices with orthogonal design and contrary logic responses. ADVS, 12(33), e01430. (www)

  @article{ , abstract = {Developing innovative multi-channel DNA logic systems with strong responses for weak inputs is of paramount significance for versatile molecular computing, information processing, smart biosensing, and early medical diagnostics. However, most previous works usually necessitate abundant inputs equivalent to signal probes or computing elements, and present only single-channel outputs, causing DNAs’ over-consumption, limited computing functions, flexibility, and maneuverability. Herein, assisted with a catalytic-hairpin-assembly (CHA) amplifier and rational orthogonal design, the first universal weak-inputs-strong-outputs DNA system (named CP-WISO) with contrary logic responses is reported, which exhibited noticeable advantages over previous works. 1) Excellent FRET effect of dual-signal DNA probes (Cy3/Cy5) brought enriched contrary logic output channels; 2) One-step CHA amplification avoided DNAs’ over-consumption, high cost, and complexity; 3) A library of CP-WISO DNA logic nanodevices with the manipulated orthogonal design is realized, accompanied with enhanced flexibility, maneuverability, and computing proficiency; 4) Even and odd parity generators/checkers (pG/pC) are concurrently operated based on the “XOR∧XNOR”-type CP-WISO nanodevice, ensuring the recognition of erroneous bits and secure molecular data transmission; 5) Additionally, taking miRNA-499, miRNA-21 and miRNA-122 as alternative model targets, the “YES∧NOT” and “AND∧NAND” CP-WISO nanodevices achieved intelligent identification and ratiometric fluorescent detection of miRNAs in human serums, promoting the early diagnostics of acute myocardial infarction and liver cancer.}, archive = {J_ADVS}, author = {Xujuan Lv and Jiawen Han and Juan Wang and Zhihua Lv and Baojian Huang and Shuai Qin and Xuxin Yan and Shaojun Dong and Daoqing Fan}, doi = {10.1002/advs.202501430}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01430}, shortjournal = {Adv. Sci.}, title = {Catalytic hairpin assembly-propelled weak-inputs-strong-outputs (CP-WISO) DNA logic nanodevices with orthogonal design and contrary logic responses}, volume = {12}, year = {2025}, }
• (2025). NDRG1-driven lactate accumulation promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment. ADVS, 12(33), e01238. (www)

  @article{ , abstract = {Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, with the tumor microenvironment (TME) playing a critical role in its progression. Metabolic reprogramming, particularly lactate accumulation, drives immune suppression within the TME. Utilizing single-cell RNA sequencing (scRNA-seq) of 30 LUAD samples, genome-wide association studies (GWAS) involving 29,863 patients and 55,586 controls, and clinical data from 220 LUAD patients, we identified N-Myc downstream-regulated gene 1 (NDRG1) as a key pathogenic gene in LUAD, strongly associated with tumor progression and poor prognosis. Mechanistic studies revealed that NDRG1 stabilizes lactate dehydrogenase A (LDHA) by inhibiting its ubiquitination, thereby enhancing glycolysis and promoting lactate accumulation. This process fosters immune suppression by inducing M2 macrophage polarization, impairing CD8 + T cell function, and upregulating immunosuppressive genes. Furthermore, histone H3K18 lactylation in macrophages exacerbates this immunosuppressive state. Clinically, elevated NDRG1 expression correlates with increased PD-L1 levels, a higher abundance of immunosuppressive macrophages, and reduced CD8 + T cell infiltration, contributing to immunotherapy resistance. Conversely, low NDRG1 expression is associated with enhanced CD8 + T cell infiltration and improved therapeutic outcomes. Preclinical studies demonstrated targeting NDRG1 suppresses tumor growth, alleviates immune suppression, and boosts anti-PD-L1 efficacy. These findings establish NDRG1 as a critical LUAD regulator and a promising immunotherapy target.}, archive = {J_ADVS}, author = {Gujie Wu and Hongxia Cheng and Jiacheng Yin and Yuansheng Zheng and Haochun Shi and Binyang Pan and Ming Li and Mengnan Zhao and Jiaqi Liang and Yunyi Bian and Guangyao Shan and Guoshu Bi and Weigang Guo and Lin Wang and Yiwei Huang}, doi = {10.1002/advs.202501238}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01238}, shortjournal = {Adv. Sci.}, title = {NDRG1-driven lactate accumulation promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment}, volume = {12}, year = {2025}, }
• (2025). Research progress on biomaterials with immunomodulatory effects in bone regeneration. ADVS, 12(33), e01209. (www)

  @article{ , abstract = {The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive bone defects and osteolytic conditions. This review critically evaluates recent advancements in immunomodulatory biomaterials for bone repair, integrating perspectives from both immunology and materials science. It offers a comprehensive analysis of key design strategies and the underlying principles guiding the development of these biomaterials, with a particular focus on their physical and chemical properties, bioactive molecule delivery systems, cell transplantation techniques, and responses to external stimuli. Additionally, this review examines the interactions between these biomaterials and immune cells, particularly macrophages, within various pathological contexts. Finally, the paper discusses current challenges and future directions, aiming to provide researchers and clinicians with a valuable resource for advancing this rapidly evolving field.}, archive = {J_ADVS}, author = {Jianan Li and Ying Qu and Bingyang Chu and Tingkui Wu and Meng Pan and Dong Mo and Lang Li and Yang Ming and Yun Yang and Meng Wang and Xinlong He and Zhiyong Qian}, doi = {10.1002/advs.202501209}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01209}, shortjournal = {Adv. Sci.}, title = {Research progress on biomaterials with immunomodulatory effects in bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Crystalline-amorphous heterostructure: A novel configuration for silver nanoclusters. ADVS, 12(33), e01186. (www)

  @article{ , abstract = {Heterostructured composite materials with multiple components have potential applications in diverse aspects, as they tend to exhibit superior physicochemical properties than the sum of their single counterparts. However, the fabrication of heterostructures composed of atomic-precise metal nanoclusters (NCs) is seldom reported owing to their inherent instability, leading to the decomposition of metal NCs during the formation of peripheral layers. Here, a spontaneously formed amorphous-crystalline heterostructured Ag 40 @Ag 12 is discovered, wherein the amorphous Ag 40 NCs are enveloped by a single crystal of Ag 12 NCs. The formation of Ag 40 @Ag 12 involves three stages, including initial crystallization of Ag 40 NCs, partial decomposition (self-sacrifice) of Ag 40 NCs enabling Ag 12 assembly, and epitaxial-growth crystallization of the Ag 12 NCs. The partially decomposed Ag 40 NCs provide starting materials for the formation and crystallization of Ag 12 NCs to encapsulate the Ag 40 seeds, while the residual Ag 40 loses its crystallinity in solution simultaneously. This work not only reports a novel class of heterostructured materials for the first time but also provides new insights into the macroscopic co-assembly of distinct silver clusters.}, archive = {J_ADVS}, author = {Jia-Hong Huang and Yao Cui and Peng Luo and Zhao-Yang Wang and Shuang-Quan Zang}, doi = {10.1002/advs.202501186}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01186}, shortjournal = {Adv. Sci.}, title = {Crystalline-amorphous heterostructure: A novel configuration for silver nanoclusters}, volume = {12}, year = {2025}, }
• (2025). Single-cell RNA sequencing delineates renal anti-fibrotic mechanisms mediated by TRPC6 inhibition. ADVS, 12(33), e01175. (www)

  @article{ , abstract = {Chronic kidney disease (CKD) is characterized by persistent inflammation and tubulointerstitial fibrosis leading to end-stage renal disease. Transient receptor potential canonical 6 (TRPC6) channel inhibition mitigates tubular injury and renal fibrosis in murine models of unilateral ureteral obstruction (UUO) and 2-month chronic post–ischemia-reperfusion injury (2m post-I/R). Through integrated analysis of single-cell-RNA-sequencing (scRNA-Seq) data from UUO mice treated with the selective TRPC6 inhibitor SH045, here the renoprotective cell composition and cell type-specific transcriptional programs are defined. We explored translational aspects by conducting an in-depth scRNA-Seq analysis of kidney samples from patients with CKD. These results reveal global transcriptional shifts with a dramatic diversification of inflammatory cells, endothelial cells and fibroblasts. Notably, a distinct subpopulation of novel endothelial cells is delineated, which is termed ECRIN, that regulate inflammatory networks implicating VEGF and GAS signaling pathways. The data also indicates that inhibition of TRPC6 channels triggers a Prnp transcription factor regulatory network, which contributes to the alleviation of renal fibrosis. The key findings are supported at the protein level by immunofluorescence and western blot analysis. We observed similar patterns in the chronic 2m postI/R injury model. These findings provide novel insights into the potential therapeutic benefits of TRPC6 inhibition in CKD.}, archive = {J_ADVS}, author = {Yao Xu and Zhihuang Zheng and Marleen Silke Oswald and Guozhe Cheng and Jun Liu and Qidi Zhai and Ute Kruegel and Michael Schaefer and Holger Gerhardt and Nicole Endlich and Maik Gollasch and Stefan Simm and Dmitry Tsvetkov}, doi = {10.1002/advs.202501175}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e01175}, shortjournal = {Adv. Sci.}, title = {Single-cell RNA sequencing delineates renal anti-fibrotic mechanisms mediated by TRPC6 inhibition}, volume = {12}, year = {2025}, }
• (2025). 3D brain vascular niche model captures glioblastoma infiltration, dormancy, and gene signatures. ADVS, 12(33), e00689. (www)

  @article{ , abstract = {Glioblastoma (GBM) is a lethal brain cancer with no effective treatment; understanding how GBM cells respond to tumor microenvironment remains challenging as conventional cell cultures lack proper cytoarchitecture while in vivo animal models present complexity all at once. Developing a culture system to bridge the gap is thus crucial. Here, a multicellular approach is employed using human glia and vascular cells to optimize a 3D brain vascular niche model that enabled not only long-term culture of patient derived GBM cells but also recapitulation of key features of GBM heterogeneity, in particular invasion behavior and vascular association. Comparative transcriptomics of identical patient derived GBM cells in 3D and in vivo xenotransplants models revealed that glia-vascular contact induced genes concerning neural/glia development, synaptic regulation, as well as immune suppression. This gene signature displayed region specific enrichment in the leading edge and microvascular proliferation zones in human GBM and predicted poor prognosis. Gene variance analysis also uncovered histone demethylation and xylosyltransferase activity as main themes for gene adaption of GBM cells in vivo. Furthermore, the 3D model also demonstrated the capacity to provide a quiescence and a protective niche against chemotherapy.}, archive = {J_ADVS}, author = {Vivian K. Lee and Rut Tejero and Nathaniel Silvia and Anirudh Sattiraju and Aarthi Ramakrishnan and Li Shen and Alexandre Wojcinski and Santosh Kesari and Roland H. Friedel and Hongyan Zou and Guohao Dai}, doi = {10.1002/advs.202500689}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e00689}, shortjournal = {Adv. Sci.}, title = {3D brain vascular niche model captures glioblastoma infiltration, dormancy, and gene signatures}, volume = {12}, year = {2025}, }
• (2025). Organization of the proteostasis network of membraneless organelles. ADVS, 12(33), e00233. (www)

  @article{ , abstract = {Membraneless organelles (MLOs) are dynamic macromolecular condensates that act as crucibles to modulate cellular processes. Since MLOs form in the absence of lipid membranes, it is important to understand how their effective regulation is achieved by the protein homeostasis (proteostasis) system. To address this question, a comprehensive mapping of the proteostasis network (PN) of MLOs, comprising over 220 000 protein–protein interactions is reported. This analysis reveals how regulatory proteins (PN proteins) occupy central roles in the overall protein–protein interaction network of MLOs. It is then investigated which branches of the PN are most important in the regulation of MLOs, finding that the anabolic component, which makes up ≈30% of the PN, is more closely involved than the catabolic component, which makes up the remaining ≈70% of the PN. It is also found that translation-related PN proteins and molecular chaperones play central roles in MLO regulation. Finally, how specificity may be achieved despite shared PN components is explored. These findings suggest that HSP70 chaperones function as generic MLO regulators, while client-specific HSP70 co-chaperones confer specificity to the chaperone action. These results identify the composition of the PN of MLOs, rationalize its organization, and reveal central roles of molecular chaperones in protein regulation within MLOs.}, archive = {J_ADVS}, author = {Christine M. Lim and Yuqi Bian and Alicia González Díaz and Frank Pun and Alex Zhavoronkov and Richard I. Morimoto and Michele Vendruscolo}, doi = {10.1002/advs.202500233}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e00233}, shortjournal = {Adv. Sci.}, title = {Organization of the proteostasis network of membraneless organelles}, volume = {12}, year = {2025}, }
• (2025). Single-cell and spatial transcriptomic profiling of penile squamous cell carcinoma reveals dynamics of tumor differentiation and immune microenvironment. ADVS, 12(33), e00216. (www)

  @article{ , abstract = {Penile squamous cell carcinoma (PSCC) is a highly aggressive malignancy without effective treatment due to limited knowledge of its development and tumor microenvironment (TME). In this study, single-nucleus RNA sequencing (snRNA-seq) and high-resolution spatial transcriptomics are employed to comprehensively investigate the development trajectories and the TME. The results revealed that PSCC cells mimicked the differentiation and tissue organization of normal penile epithelium, independent of the human papillomavirus (HPV) infection status. Notably, a spatial subtype, Tum_1, appeared at early stage of tumor differentiation and in tumor–normal boundary regions. This subtype exhibited enhanced basal-like and stemness features and showed high LAMC2 expression, which activated laminin-integrin signaling via ITGA6/ITGB4, promoting tumor invasiveness. Furthermore, the results indicated that HPV-positive basal stem-like neoplasms dampened the immune function of T cells and macrophages, promoting an immunosuppressive environment that facilitates tumor progression. Supporting this, the patients with head and neck squamous cell carcinoma and lung squamous cell carcinoma who have high expression of HPV-positive Tum_1 signatures derived greater benefit from PD-1 blockade therapy. In summary, the findings provide a comprehensive spatial landscape of the PSCC TME and suggest potential treatment approaches targeting laminin-integrin interaction and immunotherapy, especially in HPV-positive patients.}, archive = {J_ADVS}, author = {Hongjian Song and Zhichao Tong and Guixiang Xie and Yaowei Li and Yubo Zhao and Fengpu Fan and Zongzheng Yang and Qing Shi and Qian Zhang and Feng Wen and Hongxue Meng and Haonan Li and Pengyu Guo and Dayong Hou and Zhenwei Zhang and Zhihao Yin and Ziyi Liu and Jianwei Wang and Peng Zhang and Peng Dai and Changfu Li and Lichen Teng and Yangyang Xu and Dexin Ding and Tao Xu and Jianzhang Li and Yongsheng Chen and Yu Qiu and XiaoWei Hu and Wentao Liu and Liang Wu and Roman Nawroth and Guibo Li and Hang Su and Ziqing Deng and Ziqi Wang and Di Wang and Wanhai Xu}, doi = {10.1002/advs.202500216}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e00216}, shortjournal = {Adv. Sci.}, title = {Single-cell and spatial transcriptomic profiling of penile squamous cell carcinoma reveals dynamics of tumor differentiation and immune microenvironment}, volume = {12}, year = {2025}, }
• (2025). Lactate-activated GPR132-src signal induces macrophage senescence and aggravates atherosclerosis under diabetes. ADVS, 12(33), e00141. (www)

  @article{ , abstract = {Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various mechanisms. Although both conditions are linked to the aging process, the relationship among cellular senescence, diabetes, and atherosclerosis remains inadequately understood. This study presents evidence that elevated glucose levels expedite the progression of atherosclerosis by promoting macrophage senescence. Increased glucose levels are shown to induce senescence in macrophages, which enhances the uptake of oxidized low-density lipoprotein (ox-LDL) and facilitates the formation of foam cells. This mechanism is driven by lactate production via glycolysis, which activates the lactate receptor GPR132, thereby promoting macrophage senescence. The activation of GPR132 is implicated in mediating senescence and lipid uptake through Src phosphorylation. The deletion of GPR132 markedly reduces macrophage senescence and atherosclerosis in mouse models. Furthermore, saracatinib, a specific Src inhibitor, has been demonstrated to effectively alleviate diabetic atherosclerosis in experimental settings. In clinical samples, elevated plasma lactate levels and the activation of the GPR132-Src pathway in peripheral blood mononuclear cells (PBMCs) are positively associated with coronary stenosis. These findings propose a potential mechanism through which diabetes accelerates atherosclerosis via the lactate-GPR132-Src pathway, underscoring macrophage senescence as a pivotal target in the context of diabetic atherosclerosis.}, archive = {J_ADVS}, author = {Xiaofeng Ge and Shuying Wang and Zhaokai Li and Jing Yu and Binbin Liu and Ruiying Wang and Shichen Bu and Nawsher wan and Yan Wang and Cuilian Dai and Yijun Lin}, doi = {10.1002/advs.202500141}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {e00141}, shortjournal = {Adv. Sci.}, title = {Lactate-activated GPR132-src signal induces macrophage senescence and aggravates atherosclerosis under diabetes}, volume = {12}, year = {2025}, }
• (2025). Nucleotides as an anti-aging supplementation in older adults: A randomized controlled trial (TALENTs study). ADVS, 12(33), 2417728. (www)

  @article{ , abstract = {Aging impairs nutrient metabolism and accelerates biological aging, negatively affecting health and longevity. The Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs) trial (ClinicalTrials.gov: NCT05243108) aimed to explore whether nucleotides (NTs) supplementation can delay biological aging and improve health outcomes in the elderly. The trial is a 19-week, double-blind, randomized, placebo-controlled study in Chengdu, China, with 121 participants (60–70 years). Participants are randomly assigned to either NTs (1.2 g day −1 ) or placebo group (1:1). The results of primary outcomes showed that NTs had significantly greater reduction in median DNA methylation age compared to placebo over 19 weeks (β = −3.08 years, 95% CI: −5.07 to −1.10, P = 0.0023), with a trend toward reduction observed over 11 weeks (β = −1.94 years, 95% CI: −4.32 to 0.45, P = 0.11); whereas no significant difference changes of leukocyte telomere length are showed between groups (week 11: β = 0.09, 95% CI: −0.10 to 0.29, P = 0.36; week 19: β = 0.12, 95% CI: -0.05 to 0.28, P = 0.18). Insulin sensitivity improved in the NTs group, with a significant reduction in HOMA-IR over 19 weeks (β = −0.45, 95% CI: −0.86 to −0.04, P = 0.033). No severe adverse events or significant changes in safety indicators are reported. Together, our findings establish that NTs may delay biological aging and improve insulin sensitivity with a well-tolerated safety profile.}, archive = {J_ADVS}, author = {Shuyue Wang and Lixia Song and Rui Fan and Qianqian Chen and Ruisheng Fu and Mei You and Yuxiao Wu and Meng Cai and Yong Li and Meihong Xu}, doi = {10.1002/advs.202417728}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {2417728}, shortjournal = {Adv. Sci.}, title = {Nucleotides as an anti-aging supplementation in older adults: A randomized controlled trial (TALENTs study)}, volume = {12}, year = {2025}, }
• (2025). Genetic impacts on the structure and mechanics of cellulose made by bacteria (Adv. sci. 33/2025). ADVS, 12(33), 71433. (www)

  @article{ , archive = {J_ADVS}, author = {Julie M. Laurent and Mathias Steinacher and Anton Kan and Maximilian Ritter and Mario Leutert and Siiri Bienz and David Häberlin and Naresh Kumar and André R. Studart}, doi = {10.1002/advs.71433}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {71433}, shortjournal = {Adv. Sci.}, title = {Genetic impacts on the structure and mechanics of cellulose made by bacteria (Adv. sci. 33/2025)}, volume = {12}, year = {2025}, }
• (2025). Single-cell and spatial transcriptomic profiling of penile squamous cell carcinoma reveals dynamics of tumor differentiation and immune microenvironment (Adv. sci. 33/2025). ADVS, 12(33), 71432. (www)

  @article{ , archive = {J_ADVS}, author = {Hongjian Song and Zhichao Tong and Guixiang Xie and Yaowei Li and Yubo Zhao and Fengpu Fan and Zongzheng Yang and Qing Shi and Qian Zhang and Feng Wen and Hongxue Meng and Haonan Li and Pengyu Guo and Dayong Hou and Zhenwei Zhang and Zhihao Yin and Ziyi Liu and Jianwei Wang and Peng Zhang and Peng Dai and Changfu Li and Lichen Teng and Yangyang Xu and Dexin Ding and Tao Xu and Jianzhang Li and Yongsheng Chen and Yu Qiu and XiaoWei Hu and Wentao Liu and Liang Wu and Roman Nawroth and Guibo Li and Hang Su and Ziqing Deng and Ziqi Wang and Di Wang and Wanhai Xu}, doi = {10.1002/advs.71432}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {71432}, shortjournal = {Adv. Sci.}, title = {Single-cell and spatial transcriptomic profiling of penile squamous cell carcinoma reveals dynamics of tumor differentiation and immune microenvironment (Adv. sci. 33/2025)}, volume = {12}, year = {2025}, }
• (2025). ASO therapy targeting STAU2 to inhibit pancreatic ductal adenocarcinoma progression and metastasis by regulating the PALLD-mediated EMT signaling pathway (Adv. sci. 33/2025). ADVS, 12(33), 71431. (www)

  @article{ , archive = {J_ADVS}, author = {Jiayu Ding and Hao Shen and Jiaying Ji and Jiaxing Li and Zhongrui Shi and Xuejiao Wang and Bangbang Li and Yi Hou and Wenjian Min and Chengliang Sun and Kai Yuan and Yasheng Zhu and Liping Wang and Shun-Qing Liang and Wenbin Kuang and Xiao Wang and Peng Yang}, doi = {10.1002/advs.71431}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {71431}, shortjournal = {Adv. Sci.}, title = {ASO therapy targeting STAU2 to inhibit pancreatic ductal adenocarcinoma progression and metastasis by regulating the PALLD-mediated EMT signaling pathway (Adv. sci. 33/2025)}, volume = {12}, year = {2025}, }
• (2025). Development and validation of machine learning-based marker for early detection and prognosis stratification of nonalcoholic fatty liver disease (Adv. sci. 33/2025). ADVS, 12(33), 71430. (www)

  @article{ , archive = {J_ADVS}, author = {Lushan Xiao and Lin Zeng and Jiaren Wang and Chang Hong and Ziyong Zhang and Chengkai Wu and Hao Cui and Yan Li and Ruining Li and Shengxing Liang and Qijie Deng and Wenyuan Li and Xuejing Zou and Pengcheng Ma and Li Liu}, doi = {10.1002/advs.71430}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {71430}, shortjournal = {Adv. Sci.}, title = {Development and validation of machine learning-based marker for early detection and prognosis stratification of nonalcoholic fatty liver disease (Adv. sci. 33/2025)}, volume = {12}, year = {2025}, }
• (2025). Soft bioelectronic interfaces for continuous peripheral neural signal recording and robust cross-subject decoding (Adv. sci. 33/2025). ADVS, 12(33), 71429. (www)

  @article{ , archive = {J_ADVS}, author = {Liangpeng Chen and Yang Liu and Yewei Huang and Ziyang Li and Chao Zhang and Jun Tang and Xueyuan Ling and Bowen Cao and Baowang Li and Yuan Zhang and Wenjianlong Zhou and Qin Xu and Shunchang Ma and Xiudong Guan and Dan Xiao and Jingyao Geng and Yutong Zhao and Guolin Li and Yi-xuan Wang and Wang Jia and Yuanwen Jiang and Milin Zhang and Deling Li}, doi = {10.1002/advs.71429}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {71429}, shortjournal = {Adv. Sci.}, title = {Soft bioelectronic interfaces for continuous peripheral neural signal recording and robust cross-subject decoding (Adv. sci. 33/2025)}, volume = {12}, year = {2025}, }
• (2025). In situ valence engineering of copper silicate nanozymes with enhanced peroxidase-like catalytic activity for oral disease detection (Adv. sci. 33/2025). ADVS, 12(33), 71428. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaocan Liu and Zhen Ding and Chengjing Xu and Jinming Zhang and Yufu Liu and Tianyan Chen and Shuang Dai and Xingfu Bao and Min Hu and Zhen Liu}, doi = {10.1002/advs.71428}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {71428}, shortjournal = {Adv. Sci.}, title = {In situ valence engineering of copper silicate nanozymes with enhanced peroxidase-like catalytic activity for oral disease detection (Adv. sci. 33/2025)}, volume = {12}, year = {2025}, }
• (2025). Simple protein foaming-derived 3D segregated MgO networks in epoxy composites with outstanding thermal conductivity properties (Adv. sci. 33/2025). ADVS, 12(33), 71427. (www)

  @article{ , archive = {J_ADVS}, author = {Su-Jin Ha and Young Kook Moon and Jong-Jin Choi and Byung-Dong Hahn and Cheol-Woo Ahn and Kyung-Hoon Cho and Hyun-Ae Cha}, doi = {10.1002/advs.71427}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {71427}, shortjournal = {Adv. Sci.}, title = {Simple protein foaming-derived 3D segregated MgO networks in epoxy composites with outstanding thermal conductivity properties (Adv. sci. 33/2025)}, volume = {12}, year = {2025}, }
• (2025). ROS-responsive hydrogel for localized delivery of nampt and stat3 inhibitors exhibits synergistic antitumor effects in colorectal cancer through ferroptosis induction and immune microenvironment remodeling (Adv. sci. 33/2025). ADVS, 12(33), 71424. (www)

  @article{ , archive = {J_ADVS}, author = {Chenyang Ye and Mi Mi and Saimeng Shi and Lina Qi and Shanshan Weng and Lu Wang and Yier Lu and Chao Chen and Yinuo Tan and Mengyuan Yang and Cheng Guo and Rui Bai and Xuefeng Fang and Ji Wang and Ying Yuan}, doi = {10.1002/advs.71424}, journal = {Advanced Science}, month = {9}, number = {33}, pages = {71424}, shortjournal = {Adv. Sci.}, title = {ROS-responsive hydrogel for localized delivery of nampt and stat3 inhibitors exhibits synergistic antitumor effects in colorectal cancer through ferroptosis induction and immune microenvironment remodeling (Adv. sci. 33/2025)}, volume = {12}, year = {2025}, }
• (2025). Exosomes from intestinal epithelial cells promote hepatic differentiation of liver progenitor cells in gut-liver-on-a-chip models. ADVS, 12(32), e17478. (www)

  @article{ , abstract = {Hepatic progenitor cells (HPCs) are frequently overactivated, and their differentiation into hepatocytes is impaired in advanced liver diseases. To explore the effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs, co-culture systems of Caco-2/HepaRG cell lines and intestine/HPC organoids are established in a novel gut-liver-on-a-chip. Exosomes derived from intestinal organoids are administered to mice with carbon tetrachloride (CCL4)-induced liver fibrosis. The results showed that the co-culture of HPCs and intestinal epithelial cells promoted the hepatic differentiation of HPCs, mediated by exosomes derived from intestinal epithelial cells. Treatment with exosomes derived from intestinal organoids ameliorated liver fibrosis in a mouse model of CCL4-induced liver fibrosis. A cluster of miRNAs, miR-371-373, is identified within the exosomes of the intestinal epithelial cells, which target RPS6KA2 to modulate hepatic differentiation. This findings demonstrate that exosomes from intestinal epithelial cells promote the hepatic differentiation of HPCs. Exosomes from intestinal organoids may be a novel therapeutic strategy for the treatment of advanced liver diseases.}, archive = {J_ADVS}, author = {Liang Ye and Shi Li and Guofang Bi and Binghui Li and Zhai Cai and Meixian Jin and Ying Zhang and Wanren Yang and Yang Li and Shao Li and Wei Hu and Yi Gao and Mingxin Pan and Shuqin Zhou and Chao Zhang and Huichang Bi and Qing Peng}, doi = {10.1002/advs.202417478}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e17478}, shortjournal = {Adv. Sci.}, title = {Exosomes from intestinal epithelial cells promote hepatic differentiation of liver progenitor cells in gut-liver-on-a-chip models}, volume = {12}, year = {2025}, }
• (2025). BrainFusion: A low-code, reproducible, and deployable software framework for multimodal Brain‒Computer interface and Brain‒Body interaction research. ADVS, 12(32), e17408. (www)

  @article{ , abstract = {This study presents BrainFusion, a unified software framework designed to improve reproducibility and support translational applications in multimodal brain–computer interface (BCI) and brain–body interaction research. While ​electroencephalography (EEG)​​-based BCIs have advanced considerably, integrating multimodal physiological signals remains hindered by analytical complexity, limited standardization, and challenges in real-world deployment. BrainFusion addresses these gaps through standardized data structures, automated preprocessing pipelines, cross-modal feature engineering, and integrated machine learning modules. Its application generator further enables streamlined deployment of workflows as standalone executables. Demonstrated in two case studies, BrainFusion achieves 95.5% accuracy in within-subject EEG–functional near-infrared spectroscopy (fNIRS)​​ motor imagery classification using ensemble modeling and 80.2% accuracy in EEG–electrocardiography (ECG)​​ sleep staging using deep learning, with the latter successfully deployed as an executable tool. Supporting EEG, fNIRS, electromyography (EMG)​, and ECG, BrainFusion provides a low-code, visually guided environment, facilitating accessibility and bridging the gap between multimodal research and application in real world.}, archive = {J_ADVS}, author = {Wenhao Li and Chenyang Gao and Zhaobo Li and Yunheng Diao and Jiaxin Li and Jiayi Zhou and Jing Zhou and Ying Peng and Guanchu Chen and Xuecheng Wu and Kai Wu}, doi = {10.1002/advs.202417408}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e17408}, shortjournal = {Adv. Sci.}, title = {BrainFusion: A low-code, reproducible, and deployable software framework for multimodal Brain‒Computer interface and Brain‒Body interaction research}, volume = {12}, year = {2025}, }
• (2025). Inhibition of UBE2C promotes parkin-mediated k63-linked ubiquitination of TOP2A to induce senescence and increase sensitivity of doxorubicin in breast cancer. ADVS, 12(32), e17348. (www)

  @article{ , abstract = {Breast cancer is now the second most commonly diagnosed cancer and the most common female malignancy. Chemotherapy-based adjuvant therapy after surgery and neoadjuvant therapy before surgery are cornerstones of breast cancer treatment. Doxorubicin is one of the most commonly used anthracycline chemotherapy treatments for breast cancer; however, doxorubicin resistance is a major barrier to its clinical use. Therefore, there is an urgent need to discover new targets to overcome doxorubicin resistance in breast cancer. Ubiquitin-conjugating enzyme 2C (UBE2C) is an E2 ubiquitin-conjugating enzyme that catalyzes the assembly of K11-linked ubiquitin chains. In recent years, dysregulation of UBE2C has been implicated in a variety of cancers, including breast cancer; however, the underlying mechanisms remain unclear. In the present study, UBE2C was found to be markedly upregulated in breast cancer and transcriptionally regulated by FOXM1. Inhibition of UBE2C suppressed proliferation and induced senescence in breast cancer cells. Moreover, the inhibition of UBE2C promoted Parkin-mediated K63-linked ubiquitination of TOP2A, leading to its proteasomal degradation and thus sensitizing breast cancer cells to doxorubicin. The study reveals that UBE2C is a critical regulator of breast cancer cell proliferation, senescence, and sensitivity to doxorubicin.}, archive = {J_ADVS}, author = {Yihui Yang and Wan Li and Hong Yang and Fang Xu and Sen Zhang and Wanxin Cao and Xiaoxue Li and Xu Zhang and Xiangyin Chi and Hongquan Wang and Guanhua Du and Yumin Wang and Jinhua Wang}, doi = {10.1002/advs.202417348}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e17348}, shortjournal = {Adv. Sci.}, title = {Inhibition of UBE2C promotes parkin-mediated k63-linked ubiquitination of TOP2A to induce senescence and increase sensitivity of doxorubicin in breast cancer}, volume = {12}, year = {2025}, }
• (2025). Dual-energy CT-based assessment of thrombotic heterogeneity for predicting stroke source and response to machine thrombectomy: A step toward visualization thrombus treatment. ADVS, 12(32), e17295. (www)

  @article{ , abstract = {The viability of using thrombus heterogeneity (TH) data derived from dual-energy CT (DECT) as a visual thrombotic biomarker is unclear. The first aim of this study is to develop a quantitative measure of TH on DECT and test its performance for predicting the stroke source (cardiogenic vs. non-cardiogenic) and clinical outcomes (functional status assessed by the modified Rankin Scale score at 90 days) following machine thrombectomy (MT). The second aim is to associate thrombus subregions with the thrombus composition to facilitate visualization of thrombus constituents. Radiomics data are extracted from the whole thrombus and subregions in CT/DECT to construct predictive models. The performances of all models are evaluated and compared in the validation and comparative cohorts. Histopathologic analysis is performed to correlate the subregion data with the actual thrombus composition. This study included 221 and 255 participants who underwent DECT and CT examinations, respectively. DECT outperformed CT in predicting stroke source and clinical outcomes, with the TH-related models showing the highest performance in the validation and comparative cohorts. Thrombus composition is correlated with the different CT/DECT-based subregions, with DECT-habitat_c showing the strongest association. Thrombus subregion analyses may help visualize the related constituents.}, archive = {J_ADVS}, author = {Jingxuan Jiang and Sijia Wang and Fan Xiao and Hongmei Gu and Mingkang Wang and Hao Tian and Baohui Guan and Kai Sheng and Yijia Xiong and Huilin Zhao and Minda Li and Li Xu and Zheng Sun and Haiyan Du and Wenxian Du and Yuehua Li}, doi = {10.1002/advs.202417295}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e17295}, shortjournal = {Adv. Sci.}, title = {Dual-energy CT-based assessment of thrombotic heterogeneity for predicting stroke source and response to machine thrombectomy: A step toward visualization thrombus treatment}, volume = {12}, year = {2025}, }
• (2025). NIR driven Pd/Cerium oxide nano-heterojunction for enhanced salvaging sepsis induced acute liver injury via reprogramming redox homeostasis in synergy with inducing autophagy. ADVS, 12(32), e17252. (www)

  @article{ , abstract = {Sepsis induced acute liver injury (SALI), is a type of acute and severe disease that is generally characterized by producing significant amounts of reactive oxygen species (ROS) in liver tissue, and in response to excessive ROS, producing huge amounts of inflammatory factors by hepatocytes. Considering the crucial role of ROS in SALI, a Pd doped CeO 2 (CP) nano-heterojunction with enhanced ROS scavenging capacity is developed to act as a catalytic nanomedicine for the treatment of SALI. Combining with near infrared (NIR) irradiation, it exhibits excellent scavenging capacity of ROS including hydroxyl radical (•OH), superoxide anion (•O 2 − ), as well as singlet oxygen ( 1 O 2 ) for CP. Significantly, it also demonstrates the excellent antioxidant and anti-inflammatory activities for lipopolysaccharides (LPS) stimulated macrophages (RAW264.7), and cecum ligation and puncture (CLP) treated C57BL/6J mice via reducing intracellular ROS levels, decreasing inflammatory factors expression levels, as well as activating Keap1/Nrf-2/HO-1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation and promote liver tissue repair, finally achieving the alleviation of SALI. It provides a promising therapeutic strategy of CP+NIR with high efficacy and biosafety for the management of SALI.}, archive = {J_ADVS}, author = {Tao Qin and Lian Qin and Yang Zhao and Yin Chen and Qianyue Liu and Xiaoguang Lin and Yongfeng Lan and Yaohui Huang and Yan Liu and Ke Zhang and Lifan Pan and Jiaxiao Li and Kunpeng Duan and Hao Liang and Mingjing Yin and Guiyang Fan and Lian Liu and Yu Deng and Lin Liao and Danke Su and Ming Gao and Junyu Lu}, doi = {10.1002/advs.202417252}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e17252}, shortjournal = {Adv. Sci.}, title = {NIR driven Pd/Cerium oxide nano-heterojunction for enhanced salvaging sepsis induced acute liver injury via reprogramming redox homeostasis in synergy with inducing autophagy}, volume = {12}, year = {2025}, }
• (2025). Genomic and cis-regulatory basis of a plastic c3-c4 photosynthesis in eleocharis baldwinii. ADVS, 12(32), e15681. (www)

  @article{ , abstract = {C 4 photosynthesis is a crucial trait for efficient carbon fixation; however, the genomic basis and environmental influences on its formation remain under explored. Here, we examined Eleocharis baldwinii , a sedge that exhibits photosynthetic plasticity with C 3 -like traits underwater and C 4 -like traits on land, to expand knowledge of C 4 photosynthesis. A gap-free allopolyploid genome was assembled and a cellular expression atlas is reconstructed by applying single-nucleus RNA-seq.Subgenome dominance influencing expression of C 4 enzyme genes was detected across cell types. cis -regulatory patterns linked to the C 4 pathway, Kranz anatomy specialization, and environmental responses are evaluated using single-nucleus transposase-accessible chromatin sequencing and found that the formation of the C 4 pathway involves a few environmentally triggered, cell-specialized cis -regulatory elements. Comparative analyses between E. baldwinii and maize further implied that cis -regulator families for Kranz anatomy specialization are conserved across species, whereas those for C 4 metabolism differ, underscoring the genetic diversity underlying convergent traits. This study provides genomic and regulatory insights into how plants evolve C 4 photosynthesis, especially regarding the effects of environmental factors.}, archive = {J_ADVS}, author = {Lu Chen and Yanfeng Jia and Zaihui Zhou and Qiying Jiang and Jianlin Liu and Jianhui Gu and Chuan Chen and Shujing Cheng and Jinfang Chu and Xin Liu and Yongjun Lin and Xiang Li}, doi = {10.1002/advs.202415681}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e15681}, shortjournal = {Adv. Sci.}, title = {Genomic and cis-regulatory basis of a plastic c3-c4 photosynthesis in eleocharis baldwinii}, volume = {12}, year = {2025}, }
• (2025). Advances in single-cell sequencing for infectious diseases: Progress and perspectives. ADVS, 12(32), e15678. (www)

  @article{ , abstract = {Infectious diseases are a persistent threat throughout the twenty-first century, owing to their widespread transmission mediated by global connectivity. Benefiting from the advancement of eukaryotic, prokaryotic (e.g., MATQ-seq and BacDrop), and dual (e.g., PatH-Cap) single-cell sequencing technologies, changes in each side and host-pathogen interactions can be elucidated. Pathogens undergo adaptive evolution in the host microenvironment, exhibiting different transcription profiles (e.g., upregulated HSV-1 immediate-early genes during infection), transcription efficiencies, and others. Consequently, they develop distinct replication capacity, virulence, and other phenotypes. For the host, intrinsic differences among cells and variations brought by diverse phenotypic pathogens together determine the heterogeneity of its responses (e.g., the dual roles of interferon-I at different infection stages). Interferon-related pathway alterations (influencing both adaptive and innate immune responses) and cell exhaustion (manifesting as the functional impairment of cells) are observed in various infections, seemingly as a shared approach in host-pathogen interactions. These underlying commonalities provide a basis for the development of broad-spectrum therapeutic targets. Collectively, this work reviewed recent progress of single-cell sequencing technologies and their applications in infectious diseases, aiming to facilitate the development of powerful diagnostic or therapeutic strategies and thus advance precision medicine.}, archive = {J_ADVS}, author = {Mengyuan Lyu and Yang Liu and Jian Zhou and Hongli Lai and Hongxia Ruan and Dongsheng Wu and Shun Zhu and Xudong Zhou and Wananqi Ma and Yuchen Huang and Shuting Lei and Han Luo and Jie Chen and Binwu Ying}, doi = {10.1002/advs.202415678}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e15678}, shortjournal = {Adv. Sci.}, title = {Advances in single-cell sequencing for infectious diseases: Progress and perspectives}, volume = {12}, year = {2025}, }
• (2025). Gentle label-free nonlinear optical imaging relaxes linear-absorption-mediated triplet. ADVS, 12(32), e15648. (www)

  @article{ , abstract = {Sample health is critical for live-cell fluorescence microscopy and has promoted light-sheet microscopy that restricts its ultraviolet–visible excitation to one plane inside a 3D sample. It is thus intriguing that laser-scanning nonlinear optical microscopy, which similarly restricts its near-infrared excitation, has not broadly enabled gentle label-free molecular imaging. It is hypothesized that intense near-infrared excitation induces phototoxicity via linear absorption of intrinsic biomolecules with subsequent triplet buildup, rather than the commonly assumed mechanism of nonlinear absorption. Using a reproducible phototoxicity assay based on the time-lapse elevation of autofluorescence (hyper-fluorescence) from a homogeneous tissue model (chicken breast), strong evidence is provided supporting this hypothesis. The study justifies a simple imaging technique, e.g., rapidly scanned sub-80-fs excitation with full triplet-relaxation, to mitigate this ubiquitous linear-absorption-mediated phototoxicity independent of sample types. The corresponding label-free imaging can track freely moving C. elegans in real-time at an irradiance up to one-half of water optical breakdown.}, archive = {J_ADVS}, author = {Geng Wang and Lianhuang Li and Janet E. Sorrells and Jianxin Chen and Haohua Tu}, doi = {10.1002/advs.202415648}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e15648}, shortjournal = {Adv. Sci.}, title = {Gentle label-free nonlinear optical imaging relaxes linear-absorption-mediated triplet}, volume = {12}, year = {2025}, }
• (2025). Enhanced activities of OCT4 and SOX2 promote epigenetic reprogramming by shortening g1 phase. ADVS, 12(32), e15528. (www)

  @article{ , abstract = {To investigate the interplay among OCT4, SOX2, and KLF4, the VP16 activation domain is fused to one or multiple of these factors during reprogramming. Fusion of VP16 with OCT4 and SOX2 (OvSvK) significantly increases the efficiency of induced pluripotent stem cell (iPSC) generation compared to other combinations. The enhanced activities of OCT4 and SOX2 directly facilitated reprogramming by activating downstream targets, some of which are involved in cell cycle regulation. This leads to a shortened G1 phase and a shift in cell cycle dynamics toward an iPSCs-like state. Further analysis reveals that these cell cycle alterations reduced H3K27me3 levels on specific genes, thereby promoting reprogramming. Consistently, knockdown of Ccnd1 and Cdkn2a (si Ccnd1 , si Cdkn2a ) as well as overexpression of Ccne1 effectively shortened the G1 phase and enhanced reprogramming efficiency. These findings highlight the role of cell cycle modulation in epigenetic remodeling and provide mechanistic insights for optimization during somatic cell reprogramming.}, archive = {J_ADVS}, author = {Lin Guo and Jiechun Lin and Qiwen Ren and Hao Sun and Yanhua Wu and Haofei Ge and Xiaolan Wu and Lihui Lin and Lining Liang and Changpeng Li and He Liu and Yuangbang Mai and Shilong Chu and Jiadong Liu and Jing Liu and Jiekai Chen and Duanqing Pei and Hui Zheng}, doi = {10.1002/advs.202415528}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e15528}, shortjournal = {Adv. Sci.}, title = {Enhanced activities of OCT4 and SOX2 promote epigenetic reprogramming by shortening g1 phase}, volume = {12}, year = {2025}, }
• (2025). Piezoelectric biomaterials for bone regeneration: Roadmap from dipole to osteogenesis. ADVS, 12(32), e14969. (www)

  @article{ , abstract = {Piezoelectric biomaterials convert mechanical energy into electrical charges, making them promising candidates for bone tissue engineering by restoring and modulating the electrophysiological microenvironment. This review explores the development of piezoelectric biomaterials by focusing on their molecular origins, particularly dipoles, and how their type, source, and spatial arrangement influence macroscopic electromechanical coupling. Beyond intrinsic origins, the concept of pseudo-piezoelectricity driven by extrinsic factors is introduced to highlight alternative approaches for piezoelectric biomaterial design. Techniques to engineer dipoles and modulate piezoelectric properties for the regulation of osteogenesis are discussed. Particular attention is given to the correlation between piezoelectricity and osteogenesis at distinct phases of bone regeneration. Finally, current challenges in molecular understanding and biofabrication of piezoelectric bone scaffolds are highlighted, along with potential future research directions.}, archive = {J_ADVS}, author = {Xiyao Ni and Yufei Cui and Mojtaba Salehi and Mui Ling Sharon Nai and Kun Zhou and Cian Vyas and Boyang Huang and Paulo Bartolo}, doi = {10.1002/advs.202414969}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e14969}, shortjournal = {Adv. Sci.}, title = {Piezoelectric biomaterials for bone regeneration: Roadmap from dipole to osteogenesis}, volume = {12}, year = {2025}, }
• (2025). Listerin alleviates alzheimer's disease through IRE1-mediated decay of TLR4 mRNA. ADVS, 12(32), e14956. (www)

  @article{ , abstract = {Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, accounting for ≈60–70% of all dementia cases worldwide. Microglial-mediated brain inflammation is thought to play key roles in AD progression. Clinical evidence and animal models have indicated that the ribosome-associated quality control (RQC) component Listerin is involved in the development of AD. How Listerin regulates the development and progression of AD is unknown. Here, it is demonstrated that Listerin can decrease brain inflammation and alleviate AD-related cognitive impairments. Microglial-specific knockout of Listerin exhibits deteriorative cognitive symptoms based on the extracellular Amyloid-β (Aβ) or Lipopolysaccharide (LPS) injection. Mechanistically, Listerin directly binds to Toll-like receptor 4 (TLR4) mRNA and facilitates the IRE1α-mediated cleavage and degradation of TLR4 mRNA, leading to the alleviation of TLR4-induced brain inflammation. Adenovirus-mediated overexpression of Listerin decelerates the disease progression in the mouse model of Aβ-mediated neurodegeneration. Thus, Listerin is an important suppressor of microglia-induced brain inflammation and may be a potential therapeutic target for AD treatment.}, archive = {J_ADVS}, author = {Fei Qin and Runyu Cao and Xuemei Bai and Jiahua Yuan and Wanwei Sun and Yi Zheng and Xiaopeng Qi and Wei Zhao and Bingyu Liu and Chengjiang Gao}, doi = {10.1002/advs.202414956}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e14956}, shortjournal = {Adv. Sci.}, title = {Listerin alleviates alzheimer's disease through IRE1-mediated decay of TLR4 mRNA}, volume = {12}, year = {2025}, }
• (2025). Structure, mechanics, and mechanobiology of fibrocartilage pericellular matrix mediated by type v collagen. ADVS, 12(32), e14750. (www)

  @article{ , abstract = {The pericellular matrix (PCM) is the immediate microniche surrounding cells in various tissues, regulating matrix turnover, cell-matrix interactions, and disease. This study elucidates the structure-mechanical properties and mechanobiology of the PCM in fibrocartilage, using the murine meniscus as the model. The fibrocartilage PCM is comprised of thin, randomly oriented collagen fibrils that entrap proteoglycans, contrasting with the densely packed, highly aligned collagen fibers in the bulk extracellular matrix (ECM). Compared to the ECM, the PCM exhibits lower modulus and greater isotropy, but has similar relative viscoelastic properties. In Col5a1 +/− menisci, the reduction of collagen V results in thicker, more heterogeneous collagen fibrils, reduced modulus, loss of isotropy and faster viscoelastic relaxation in the PCM. Such altered PCM leads to impaired matrix–to–cell strain transmission, and in turn, disrupts mechanotransduction of meniscal cells, as illustrated by reduced calcium signaling activities and alters expression of matrix genes. In vitro, Col5a1 +/− cells produce a weakened PCM with inferior properties and reduced protection of cells against tensile stretch. These findings highlight the PCM as a distinctive microstructure in fibrocartilage mechanobiology, underscoring a pivotal role of collagen V in PCM function. Targeting the PCM or its constituents offers potential for improving meniscus regeneration, osteoarthritis intervention and broader fibrocartilage-related therapies.}, archive = {J_ADVS}, author = {Chao Wang and Mingyue Fan and Su Chin Heo and Sheila M. Adams and Thomas Li and Yuchen Liu and Qing Li and Claudia Loebel and Jason A. Burdick and X. Lucas Lu and David E. Birk and Farid Alisafaei and Robert L. Mauck and Lin Han}, doi = {10.1002/advs.202414750}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e14750}, shortjournal = {Adv. Sci.}, title = {Structure, mechanics, and mechanobiology of fibrocartilage pericellular matrix mediated by type v collagen}, volume = {12}, year = {2025}, }
• (2025). Network desynchronization with sine waves: From synchrony to asynchrony by periodic stimulation. ADVS, 12(32), e14602. (www)

  @article{ , abstract = {Understanding how brain stimulation interacts with the brain's internal dynamics is crucial for developing effective neuromodulation protocols. Here we explore the effects of exogenous alternating current (AC) fields across various amplitudes and frequencies on cortical slices expressing spontaneous slow oscillations. Cortical network entrainment occurs within an Arnold tongue-like region centered at the endogenous frequency. However, slightly detuned periodic stimulation of higher frequency leads to a desynchronized regime, revealing a novel approach for disrupting pathological synchronicity. The introduction of an additional direct current (DC) offset expands the modulatory ranges, facilitating the achievement of either entrainment or desynchronization, depending on the DC offset's polarity. The experimental observations are quantitatively reproduced by a computational model of spiking neurons, suggesting that the interaction between nonlinear oscillators can predict the network's response to AC fields. Besides an improved understanding of cortical dynamics and its interaction with exogenous electric fields, a robust protocol with potential clinical applications in pathological conditions is presented.}, archive = {J_ADVS}, author = {Joana Covelo and Martina Cortada and Gianni V. Vinci and Maurizio Mattia and Maria V. Sanchez-Vives}, doi = {10.1002/advs.202414602}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e14602}, shortjournal = {Adv. Sci.}, title = {Network desynchronization with sine waves: From synchrony to asynchrony by periodic stimulation}, volume = {12}, year = {2025}, }
• (2025). Exome sequencing reveals the genetic architecture of non-syndromic orofacial clefts and identifies BOC as a novel causal gene. ADVS, 12(32), e12073. (www)

  @article{ , abstract = {Nonsyndromic orofacial clefts (NSOFCs) are the most common human craniofacial defects. Genetic factors play a critical role in the pathogenesis of NSOFCs. However, known causal genes only explain a minority of the estimated heritability. To unveil the underlying genetic architecture, exome sequencing is performed on 214 sporadic patients with NSOFCs. The findings substantiate the genetic and allelic heterogeneity of NSOFCs and underscore the crucial role of dysregulation of OFC-related signaling pathways in the occurrence of NSOFCs. Besides, the candidate variants discovered provide a fruitful resource for further genetic studies. Particularly, three BOC missense variants (p.R407W, p.G436S, and p.D1018N) are identified in three unrelated cases with cleft palate. In parallel, a BOC nonsense variant (p.R681X), co-segregating with a GLI2 missense variant (p.A543G), is identified in a multiplex family with microform cleft lip. Functional studies demonstrate while the four BOC variants are hypomorphic alleles, the GLI2 variant is a hypermorphic allele. The counteraction between BOC p.R681X allele and GLI2 p.A543G allele accounts for the mild phenotype in the multiplex family. Thus, this study establishes BOC as a novel causal gene and implicates a two-locus model of inheritance via the epistatic antagonism of two SHH pathway variants in NSOFCs.}, archive = {J_ADVS}, author = {Qing He and Min Yu and Yuhua Jiao and Yizhu Xu and Xuqin Liang and Wenbin Huang and Linping Xu and Yuxia Hou and Zhanping Ren and Beile Lyu and Zhenwei Qian and Pengpeng Liu and Jing Zhou and Huimei Huang and Chunyan Yin and Huaxiang Zhao and Yi Ding}, doi = {10.1002/advs.202412073}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e12073}, shortjournal = {Adv. Sci.}, title = {Exome sequencing reveals the genetic architecture of non-syndromic orofacial clefts and identifies BOC as a novel causal gene}, volume = {12}, year = {2025}, }
• (2025). Correction to “A dual-response DNA origami platform for imaging and treatment of sepsis-associated acute kidney injury”. ADVS, 12(32), e10994. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202510994}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e10994}, shortjournal = {Adv. Sci.}, title = {Correction to “A dual-response DNA origami platform for imaging and treatment of sepsis-associated acute kidney injury”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Targeting senescence with apigenin improves chemotherapeutic efficacy and ameliorates age-related conditions in mice”. ADVS, 12(32), e10217. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202510217}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e10217}, shortjournal = {Adv. Sci.}, title = {Correction to “Targeting senescence with apigenin improves chemotherapeutic efficacy and ameliorates age-related conditions in mice”}, volume = {12}, year = {2025}, }
• (2025). Corrections to EGF relays signals to COP1 and facilitates FOXO4 degradation to promote tumorigenesis - Choi - 2020 - Advanced science - Wiley online library. ADVS, 12(32), e08233. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202508233}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e08233}, shortjournal = {Adv. Sci.}, title = {Corrections to EGF relays signals to COP1 and facilitates FOXO4 degradation to promote tumorigenesis - Choi - 2020 - Advanced science - Wiley online library}, volume = {12}, year = {2025}, }
• (2025). Deep learning-assisted rapid bacterial classification based on raman spectroscopy of bacteria lysed by acoustically driven fiber-tip vibration. ADVS, 12(32), e07724. (www)

  @article{ , abstract = {Rapid and accurate identification of bacterial pathogens is critical for effective clinical decision-making and combating antibiotic resistance. Surface-enhanced Raman spectroscopy (SERS) combined with machine learning (ML) offers a powerful method for rapid, label-free bacterial identification. Conventional methods rely on surface molecular structures for identification, yet the richer and unique spectral information from intracellular biomolecules is often masked by the bacterial envelope, limiting classification accuracy. Here, a novel bacterial classification method is demonstrated by introducing acoustofluidic lysis based on the vibrating fiber-tip, combined with Raman spectroscopy and deep learning. The fiber-tip oscillates in a torsional mode, generating a controlled single-vortex within a capillary to concentrate bacteria in high-shear regions, enhancing lysis efficiency. This process effectively exposes intracellular components such as nucleic acids, proteins, and lipids, significantly enhancing the expression of features in bacterial Raman spectra, improving both spectral resolution and information richness. A residual neural network (ResNet) model is further employed for automated classification, achieving 98.9% accuracy across seven bacterial samples, surpassing traditional classifiers like random forests. The clinical validation experiments highlight the method's potential for real-world applications, enabling direct, on-site detection of clinical samples and facilitating rapid diagnostics, thus offering a promising advancement in pathogen identification.}, archive = {J_ADVS}, author = {Yukai Liu and Miaomiao Ji and Xiao Ren and Zhenyong Dong and Tian Wen and Qingyue Dong and Ho-pui Ho and Lunbiao Cui and Yanqing Lu and Guanghui Wang}, doi = {10.1002/advs.202507724}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e07724}, shortjournal = {Adv. Sci.}, title = {Deep learning-assisted rapid bacterial classification based on raman spectroscopy of bacteria lysed by acoustically driven fiber-tip vibration}, volume = {12}, year = {2025}, }
• (2025). Molecularly engineered hydrogel electrolyte embedded with multifunctional oxygen-rich macrocyclic units for uniform zinc deposition. ADVS, 12(32), e07377. (www)

  @article{ , abstract = {Hydrogel electrolyte has emerged as an effective strategy for stabilizing zinc anode. Despite certain advancements in network design, solely relying on simple combinations of traditional polymer chains or single-function monomers is far from satisfactory in overcoming multiple challenges faced by zinc-ion battery. Herein, a novel multifunctional monomer, benzo-15-crown-5-acrylamide (BCAm), is designed and introduced into hydrogel network (PBCM-HE), aiming to regulate solvation sheath structure with supramolecular macrocyclic units. Specifically, rigid benzene rings in BCAm units can stabilize conformation of crown ether and bestow PBCM-HE excellent mechanical properties with tensile-strength of 105 kPa and compressive-strength of 0.6 MPa. Critically, the locally electron-rich ether bonds in supramolecular macrocycle can optimize solvation structure of hydrated zinc ions and promote ion transport, stabilizing interface interaction between electrolyte and Zn anode. Given this, PBCM-HE possesses outstanding ionic conductivity (61.7 mS cm −1 ) and remarkable transference number (0.86). Besides, the Zn||PBCM-HE||MnO 2 full cells show excellent discharge specific capacity of 290.9 mAh g −1 at 0.1 C with Zn uniform deposition. This work innovatively develops a novel hydrogel electrolyte network with multifunctional monomer through one-step polymerization, providing new insights and possibilities for monomer design and selection in hydrogel electrolytes, further paving the way for exploring high-performance electrolytes in zinc-based devices.}, archive = {J_ADVS}, author = {Miao Sun and Guochen Ji and Meizhi Li and Junping Zheng}, doi = {10.1002/advs.202507377}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e07377}, shortjournal = {Adv. Sci.}, title = {Molecularly engineered hydrogel electrolyte embedded with multifunctional oxygen-rich macrocyclic units for uniform zinc deposition}, volume = {12}, year = {2025}, }
• (2025). Multicolor luminescent supramolecular bidirectional shuttles driven by light. ADVS, 12(32), e07090. (www)

  @article{ , abstract = {Possessing special photophysical behavior, supramolecular space-confined assembly is widely applied in bioimaging, information anti-counterfeiting, and luminescent materials. Herein, two different multicolor luminescent supramolecular bidirectional shuttles driven by light are reported, which are constructed by spiropyran-modified p -styrene derivatives (BPSP), cucurbit[7]uril (CB[7]) and cucurbit[8]uril (CB[8]). CB[7] encapsulated BPSP not only effectively enhance the fluorescence intensity both in the ring-closed and ring-open states accompanied with multicolor luminescence from blue to red, but also produce ortho-hexagonal nanosheets. Different from CB[7], the binding of CB[8] to BPSP formed a nanospherical topological morphology. It induce the red-shift of fluorescence from blue to yellow, which completely transform into red fluorescence in the dark. Both the multicolor luminescence and topological morphology can be reversibly regulate under alternating visible light and darkness. Due to the photo-controlled time-dependent multicolor reversible luminescence of the two kinds of supramolecular assemblies, they are successfully applied to logic gates, bidirectional reversible anti-counterfeiting, and controllable cell imaging, providing a new strategy for macrocycle-confined molecular assembly.}, archive = {J_ADVS}, author = {Rong Zhang and Zhuo Lei and Zhiyi Yu and Yong Chen and Yu Liu}, doi = {10.1002/advs.202507090}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e07090}, shortjournal = {Adv. Sci.}, title = {Multicolor luminescent supramolecular bidirectional shuttles driven by light}, volume = {12}, year = {2025}, }
• (2025). Confinement-induced metastable supramolecular assembly: Dynamic built-in electric field driving deep mineralization of organic pollutants. ADVS, 12(32), e06797. (www)

  @article{ , abstract = {Constructing built-in electric fields (IEF) in homomeric supramolecular assembly (SA) offers an exciting research avenue. To boost dipole, the introduction of a functional side chain in the monomer is essential. Unfortunately, this disrupts the monomer planarity, inevitably increasing intermolecular distance, which is contradictory to achieving high IEF. Here, by means of the confinement of layered double hydroxide (LDH), various monomers (naphthalene and perylene diimide derivatives) successfully form metastable SA with smaller intermolecular distances than in crystals. The IEF enhancement value can reach 11.8 times, enabling a 71.52% charge separation efficiency and a 78.10% total organic carbon (TOC) removal rate in phenol degradation, presenting state-of-the-art results. Mechanism elucidates LDH confinement overcomes the energy barrier associated with the ordered and close packing of monomers, moving monomer away from the thermodynamic equilibrium state. The universality of this approach will pave the way for exploring other multifunctional monomers, thereby fostering advancement in material science, chemical synthesis, and photo-conversion.}, archive = {J_ADVS}, author = {Xiaoqing Cao and Kaixiang Liang and Feifei Peng and Xianggui Kong and Wenying Shi}, doi = {10.1002/advs.202506797}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06797}, shortjournal = {Adv. Sci.}, title = {Confinement-induced metastable supramolecular assembly: Dynamic built-in electric field driving deep mineralization of organic pollutants}, volume = {12}, year = {2025}, }
• (2025). Wide linearity range and rapid-response tactile sensor inspired by parallel structures. ADVS, 12(32), e06783. (www)

  @article{ , abstract = {The synergistic enhancement of both linear range and response speed is crucial for simplifying the signal processing/conversion of tactile sensors and improving real-time perception. However, traditional tactile sensors face challenges in quantitatively controlling force-electrical response and viscoelastic hysteresis, limiting their linear sensing range and response speed. Inspired by parallel structures, Composite Parallel Tactile Sensors (CPTS-W and CPTS-S) is proposed, employing parallel elastomers to regulate deformation precisely. These sensors exhibit a wide sensing range up to 450 kPa, with three linear response regions: 0–50 kPa (sensitivity of 0.0080 kPa − ¹), 50–98 kPa (sensitivity of 0.0022 kPa − ¹), and 98–423 kPa (sensitivity of 0.0012 kPa − ¹), significantly reduce dynamic recovery hysteresis of conductive composites, and enhance rapid response capability (48 ms response time and 39 ms recovery time). With excellent dynamic response characteristics across a wide linear sensing range, the results demonstrate broad applicability in areas such as physiological signal monitoring, complex object shape recognition, and multi-axis torque decoupling perception in robotics.}, archive = {J_ADVS}, author = {Weihua Gao and Jiantao Yao and Xianhe Yu and Guoliang Ma and Dakai Wang and Hongnian Yu and Zhiwu Han and Luquan Ren}, doi = {10.1002/advs.202506783}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06783}, shortjournal = {Adv. Sci.}, title = {Wide linearity range and rapid-response tactile sensor inspired by parallel structures}, volume = {12}, year = {2025}, }
• (2025). A novel class of multi-substituted diaryl scaffold derivatives inhibit glioblastoma progression by targeting CD155. ADVS, 12(32), e06688. (www)

  @article{ , abstract = {Glioblastoma (GBM) is the most formidable malignancy in the brain, characterized by a significant resistance to treatment. The immune targeting of glioblastoma stem cells (GSCs) holds great promise. In this study, structural modifications of the lead compound clofoctol is conducted and structure–activity relationship analyses are performed against GBM, yielding a novel blood-brain barrier-permeable compound, B7 , featuring a pivotal multi-substituted diaryl scaffold. B7 demonstrates potent anti-GBM effects, significantly inhibiting GSC proliferation, migration, and invasion. Notably, B7 inhibits tumor progression, specifically bolstered natural killer (NK) cell-mediated cytotoxicity, and mitigates the immunosuppressive microenvironment in intracranial xenograft mice implanted with GBM cells and GSCs, as well as in cocultures of GSCs and NK-92 cells. Mechanistically, these anti-GBM effects of B7 are abolished by overexpression of poliovirus receptor cell adhesion molecule (CD155), both in vitro and in vivo . Further exploration reveals that B7 targets CD155 via interaction at five crucial binding sites, namely, L47, L108, L142, M110, and V115 residues. These interactions collectively contribute to the hydrophobic interaction energies within the B7 -CD155 complex, modulating the CD155/T cell immunoreceptor with Ig and ITIM domains/CD226 axis to reshape the NK cell-mediated tumor immune microenvironment. In conclusion, this study establishes the therapeutic potential of B7 for glioma, synergistically targeting GSC biology and NK cell immunity for the treatment of GBM.}, archive = {J_ADVS}, author = {Yong-jian Wang and Ting Sun and Si-tu Xue and Zhong-di Cai and Hong Yi and Miao Lv and Shi-bo Kou and Rui Liu and Xiao-zhong Peng and Zhuo-rong Li}, doi = {10.1002/advs.202506688}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06688}, shortjournal = {Adv. Sci.}, title = {A novel class of multi-substituted diaryl scaffold derivatives inhibit glioblastoma progression by targeting CD155}, volume = {12}, year = {2025}, }
• (2025). RUNX1/SLAMF3 axis drives immunosuppression to contribute to colorectal cancer liver metastasis by blocking phagocytosis and depleting C1QC+ tumor-associated macrophages. ADVS, 12(32), e06641. (www)

  @article{ , abstract = {Colorectal cancer liver metastasis (CRLM) is a leading cause of death in colorectal cancer (CRC) patients and is characterized by an immunosuppressive tumor microenvironment (TME). This study employs mouse in vivo selection to isolate highly metastatic CRLM derivatives for profiling their transcriptomic, proteomic, and metabolomic alterations associated with CRLM. Notably, the expression of SLAMF3 is significantly upregulated in CRLM derivatives and its knockdown effectively suppresses CRLM in mice. RUNX1 transcriptionally upregulates SLAMF3 expression and combined targeting of the RUNX1/SLAMF3 axis synergistically suppresses liver metastasis in mice. In parallel, SLAMF3 suppresses macrophage-mediated phagocytosis of CRC cells through the SHP-1/2/mTORC1 pathway. Conversely, SLAMF3 knockdown promotes M1 polarization in liver metastases and activates the CCL signaling pathway between macrophages and CD8 + T cells. It also reduces the exhausted CD8 + T cells in liver metastases and the expression of inhibitory receptors PD-1 and TIM-3, thus alleviating the immunosuppressive TME. Clinically, activation of the RUNX1/SLAMF3 axis is closely associated with CRLM progression and correlates with a reduced proportion of clinically beneficial C1QC⁺ tumor-associated macrophages (TAMs). Collectively, these findings identify the RUNX1/SLAMF3 axis as a key driver of immunosuppressive TME remodeling and CRLM progression, highlighting its potential as a promising therapeutic target for CRLM.}, archive = {J_ADVS}, author = {Yinheng Luo and Xiaoli Jin and Lan Huang and Dejia Zeng and Nan Zhang and Shiyu Tang and Shu Luo and Samina Ejaz Syed and Ruiwu Dai and Qiu Li and Shufang Liang}, doi = {10.1002/advs.202506641}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06641}, shortjournal = {Adv. Sci.}, title = {RUNX1/SLAMF3 axis drives immunosuppression to contribute to colorectal cancer liver metastasis by blocking phagocytosis and depleting C1QC+ tumor-associated macrophages}, volume = {12}, year = {2025}, }
• (2025). An ultrafast charge-driven topological intercalation prelithiation strategy for carbon-silicon composite anodes. ADVS, 12(32), e06636. (www)

  @article{ , abstract = {Prelithiation emerges as an effective technique to enhance the initial Coulombic efficiency (ICE) and cycling stability of silicon oxide based carbon composite (C/SiO x ) anodes, yet traditional approaches remain plagued by sluggish kinetics, cumbersome procedures, safety hazards, and inadequate precision. Here, a facile topological intercalation prelithiation method capable of forming a robust and homogeneous solid electrolyte interface (SEI) network on porous C/SiO x nanofiber anodes in merely 30 s is reported. Through constructing three charge-driven topology models derived from flexible SiO x /porous carbon nanofiber (SiO x /PCNF) films, the mechanism of this fast Li + -intercalation process is unraveled. Abundant surface defects on SiO x /PCNF enhance lithium salt adsorption and dissociation, while the active solvated Li + -ions can quickly intercalate into SiO x /PCNF along an orientation pathway, realizing a high ICE of 99.44%. This topological prelithiation forges a 3D inorganic-rich SEI architecture that dualizes functionality: It curtails electrolyte degradation while alleviating volume fluctuation and mechanical stress, while enabling precision Li + -ion replenishment. This topochemical paradigm not only achieves ICE reinforcement and cycling resilience (1000 stable cycles), but also slashes prelithiation duration by orders of magnitude.}, archive = {J_ADVS}, author = {Yifan Zhao and Liang Zhang and Qian Liu and Mingyu Liu and Jiajia Shen and Hui Ma and Juejing Dai and Xi Yu and Jianhua Yan}, doi = {10.1002/advs.202506636}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06636}, shortjournal = {Adv. Sci.}, title = {An ultrafast charge-driven topological intercalation prelithiation strategy for carbon-silicon composite anodes}, volume = {12}, year = {2025}, }
• (2025). Hydroxypropyl cellulose assembled microspheres as structural color barcodes from revolving microfluidics. ADVS, 12(32), e06556. (www)

  @article{ , abstract = {Optical barcodes are versatile information carriers widely applied for encryption, commercial anti-counterfeiting, and biomedical fields. Hydroxypropyl cellulose (HPC), as a natural derivative, exhibits excellent biocompatibility and can self-assemble into cholesteric liquid crystals (CLCs) with structure color. However, the high viscosity of HPC CLCs is a huge hurdle for material processing and thus limits their applications. In this study, a high-speed revolving microfluidic platform is developed for emulsifying high-viscosity methacrylate functionalized HPC (HPC-MA) solution to form droplets. HPC-MA molecules in the droplets can self-assemble into CLCs by water evaporation, and the resultant CLCs droplets can be cross-linked to form structural color barcode particles. The prepared HPC-MA CLCs barcoded particles exhibit well-defined and adjustable encoding information while maintaining excellent biocompatibility. Furthermore, the prepared barcode particles also demonstrate great potential in 3D cell culture and multiplex immunoassays. This work introduces an efficient way to continuously produce HPC-MA CLCs barcode particles with finely tunable size and uniformity. Such barcode particles are promising for widespread applications in bioanalysis and biodiagnostics.}, archive = {J_ADVS}, author = {Qiao Wang and Chong Wang and Zhonglin Fang and Zhuohao Zhang and Ye Zhao and Teng Ma and Luoran Shang}, doi = {10.1002/advs.202506556}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06556}, shortjournal = {Adv. Sci.}, title = {Hydroxypropyl cellulose assembled microspheres as structural color barcodes from revolving microfluidics}, volume = {12}, year = {2025}, }
• (2025). Active component design of amorphous SnPx/SnSx and interfacial bonding engineering in N/P/S-doped hard carbon for high-rate sodium-ion hybrid capacitors. ADVS, 12(32), e06532. (www)

  @article{ , abstract = {Sodium-ion hybrid capacitors （SIC）face critical challenges from the kinetic mismatch and cycling life imbalance between battery-type anodes and capacitive cathodes. A slope-dominant N/P/S-doped hard carbon anode (Sn0.1@NSPC) with nearly plateau-free sloping charge–discharge curves, embedded with amorphous SnP x /SnS x composites, is developed. This unique design delivers a high reversible capacity of 412.8 mAh g⁻¹ at 0.05 A g⁻¹ while retaining 180.7 mAh g⁻¹ at 10 A g⁻¹, coupled with 90% capacity retention over 10 000 cycles. The amorphous SnP x /SnS x enables isotropic Na⁺ diffusion and volume expansion suppression, while interfacial Sn─P/Sn─S bonding activates the redox potential of P/S for sodium storage through reversible Na₃P/Na₂S formation. Density functional theory calculations demonstrate that Sn doping enhances electronic states near the Fermi level and reduces sodium-ion diffusion barriers, improving conductivity and ion transport. Pseudocapacitive-dominated kinetics with reduced charge transfer resistance are achieved, synergizing with alloying/conversion reactions. In SIC paired with activated carbon, the system exhibits an energy density of 360 Wh kg⁻¹ (anode-mass-based), a power density of 38 kW kg⁻¹, and 91% capacity retention after 3000 cycles. This work establishes a universal heterostructure design via amorphous engineering and interfacial coupling, addressing trade-offs between high capacity, rapid kinetics, and long-term cycling stability in advanced SIC.}, archive = {J_ADVS}, author = {Ziyang Jia and Yichen Duan and Xi Chen and Zewen Sun and Lili Liu and Lijun Fu and Yuhui Chen and Faxing Wang and Tao Wang and Yuping Wu}, doi = {10.1002/advs.202506532}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06532}, shortjournal = {Adv. Sci.}, title = {Active component design of amorphous SnPx/SnSx and interfacial bonding engineering in N/P/S-doped hard carbon for high-rate sodium-ion hybrid capacitors}, volume = {12}, year = {2025}, }
• (2025). Thermo-responsive tri-state photonic crystals. ADVS, 12(32), e06507. (www)

  @article{ , abstract = {Counterfeiting remains a pervasive global challenge, persistently undermining legitimate enterprises. Despite advancements, current anti-counterfeiting materials and technologies fall short in addressing the escalating sophistication of counterfeit activities. A significant hurdle in this domain is the difficulty in achieving multi-mode dynamic anti-counterfeiting materials. Herein, thermo-responsive tri-state photonic crystals is presented that enable thermochromism of structural color, fluorescence (FL), and organic afterglow. The fabrication of this system integrates the incorporation of organic phosphors into polymeric colloids via solid-phase extraction and embeds thermochromic microcapsules into colloidal crystals to regulate incoherent scattering and far-field light absorption. In typical triplet-to-singlet Förster resonance energy transfer (TS-FRET) for afterglow color tuning, higher energy transfer efficiency reduces the afterglow lifetime. In contrast, the far-field light absorption-based energy transfer in this photonic crystal system avoids this trade-off, thereby preserving the long-lived triplet emission. The resultant photonic crystals exhibit three thermochromic optical states including FL, phosphorescent, and structural coloration. This general strategy, leveraging tunable thermochromic temperatures and diverse organic phosphors, enables the creation of multi-responsive anti-counterfeiting patterns. It paves the way for dynamic, high-capacity, and multimodal information storage.}, archive = {J_ADVS}, author = {Yuewei Zheng and Jinqing Chen and Wanqi Mo and Wei Hong}, doi = {10.1002/advs.202506507}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06507}, shortjournal = {Adv. Sci.}, title = {Thermo-responsive tri-state photonic crystals}, volume = {12}, year = {2025}, }
• (2025). Photovoltaic and photomultiplication dual-mode near-infrared organic detectors with large dynamic range for intensive and faint light sensing. ADVS, 12(32), e06499. (www)

  @article{ , abstract = {Conventional detectors usually operate in one detection mode, namely photovoltaic mode, photoconductive mode, or photomultiplication mode, etc., which may have limitations such as insufficient sensitivity and limited dynamic range for applications. In this study, a photovoltaic/photomultiplication dual-mode organic photodetector is developed by integrating two different organic bulk heterojunctions (BHJs), one introduces the photovoltaic effect, and the other triggers photomultiplication charge generation in the stacked device at different voltage polarities. The combination of the two operation modes largely extends the dynamic range of detectors, even superior to that of a commercial silicon detector. The ultra-low noise level of the photovoltaic mode enables it to detect faint light with exceptional sensitivity, while the photomultiplication mode can handle a significantly large saturation photocurrent, allowing for the precise detection of high-intensity signals. A dynamic range of 225 dB is achieved by precisely controlling the operation conditions of the dual-mode detector, which surpasses the dynamic range of 140 dB of a commercial silicon detector. The detector can, as a result, precisely detect light signals (800 nm) in the range of 10 −10 –10 W cm −2 . This study demonstrates the versatility of organic semiconductors in designing multi-functional and high-performing photodetectors for practical applications.}, archive = {J_ADVS}, author = {Xin Hu and Ning Li and Mingyang Ren and Yifan Ji and Hongmei Guo and Qian Chen and Xiubao Sui}, doi = {10.1002/advs.202506499}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06499}, shortjournal = {Adv. Sci.}, title = {Photovoltaic and photomultiplication dual-mode near-infrared organic detectors with large dynamic range for intensive and faint light sensing}, volume = {12}, year = {2025}, }
• (2025). Bioinspired intelligent soft robotics: From multidisciplinary integration to next-generation intelligence. ADVS, 12(32), e06296. (www)

  @article{ , abstract = {Soft robotics, distinguished by intrinsic compliance, biomimetic adaptability, and safe human-environment interaction, has emerged as a transformative paradigm in next-generation intelligent systems. Biological systems, refined through evolutionary optimization, exhibit unparalleled multifunctionality in unstructured environments, inspiring the development of soft robots with energy-efficient reconfiguration and environmental responsiveness. This review presents a comprehensive analysis of intelligent soft robotics via multidisciplinary integration, covering key aspects from bioinspired design principles to advanced functional implementation. Recent breakthroughs across four interconnected domains are systematically examined: 1) biomimetic actuation mechanisms that enhance actuation efficiency through innovative structural configurations; 2) programmable materials enabling adaptive morphology and tunable mechanical properties; 3) multiscale manufacturing techniques for fabricating complex heterogeneous structures; and 4) closed-loop control strategies integrating artificial intelligence algorithms. While highlighting emerging applications in biomedical engineering, environmental exploration, and human-machine interfaces, challenges such as actuation efficiency, material degradation, manufacturing limitations, nonlinear-control complexity, and sensing instability under real-world conditions are discussed. Furthermore, strategic research directions are identified to guide the development of next-generation soft robots endowed with embodied intelligence and adaptive functionalities. Notably, by synergizing advances in materials science, mechanical engineering, and computational intelligence, soft robotics is poised to redefine the boundaries of intelligent machines across healthcare, exploration, and human augmentation.}, archive = {J_ADVS}, author = {Xiaopeng Wang and Ruilai Wei and Zhongming Chen and Hao Pang and Haotian Li and Yang Yang and Qilin Hua and Guozhen Shen}, doi = {10.1002/advs.202506296}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06296}, shortjournal = {Adv. Sci.}, title = {Bioinspired intelligent soft robotics: From multidisciplinary integration to next-generation intelligence}, volume = {12}, year = {2025}, }
• (2025). Capturing the electrical activity of all cortical neurons: Are solutions within reach?. ADVS, 12(32), e06225. (www)

  @article{ , abstract = {Recent advancements in high-density implantable intracortical electrode technology have significantly improved neural interfaces for both research and clinical applications. However, a significant challenge persists: scaling up these devices to achieve recording of nearly all single-unit activity across large brain volumes. This critical review explores recent progress in neural electrode design, focusing on the challenges of achieving scalable solutions for this ambitious goal. The physical and technical constraints of both rigid and flexible probes are addressed, highlighting the limitations imposed by shank stiffness, mechanical tissue damage, and foreign body response. It is identified that the physics of inserting the electrodes into the brain tissue poses a fundamental constraint, which inherently restricts achievable electrode density. Biohybrid strategies, integrating biological and synthetic components, have shown promise, but they have yet to overcome the major challenges necessary to achieve a scalable functional interface. It is concluded that, given the current limitations of available techniques, there is a pressing need to explore fundamentally novel approaches to realize the vision of recording the electrical activity of every cortical neuron within the brain.}, archive = {J_ADVS}, author = {Attila Kaszás and Domokos Meszéna and Richárd Fiáth and Andrea Slézia and István Ulbert and Gergely Katona}, doi = {10.1002/advs.202506225}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06225}, shortjournal = {Adv. Sci.}, title = {Capturing the electrical activity of all cortical neurons: Are solutions within reach?}, volume = {12}, year = {2025}, }
• (2025). Ambient-pressure superconductivity onset at 10 k and robust tc under high pressure in TiNbTaN3 medium-entropy nitride. ADVS, 12(32), e06089. (www)

  @article{ , abstract = {Superconductivity has been one of the focal points in medium- and high-entropy alloys (MEAs-HEAs) since the first discovery of the HEA superconductor in 2014. Until now, most HEAs’ superconducting transition temperature ( T c ) has not exceeded 10 K. Here, the first observation of superconductivity in a bulk medium-entropy nitride (MEN), TiNbTaN 3 , which shows a T c of 10 K at ambient pressure, is reported. Notably, the electronic specific heat coefficient γ (H) exhibits nonlinear H-dependence behavior, which is similar to other well-studied multigap superconductors. Furthermore, TiNbTaN₃ exhibits extraordinary pressure resilience, maintaining robust superconductivity under high-pressure conditions. Density functional theory (DFT) calculations indicate that pressure exerts a negligible impact on the electronic structures of TiNbTaN 3 , thereby corroborating the experimental observations. These findings not only advance the understanding of emergent phenomena in entropy-stabilized nitrides but also establish a new material platform for finding more high- T c superconductors with combinations of 4 d /5 d transition metal elements and light elements, motivating further investigations into high-entropy functional ceramics for extreme environment applications.}, archive = {J_ADVS}, author = {Lingyong Zeng and Jie Wang and Hongyu Liu and Longfu Li and Jinjun Qin and Yucheng Li and Rui Chen and Jing Song and Yusheng Hou and Huixia Luo}, doi = {10.1002/advs.202506089}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e06089}, shortjournal = {Adv. Sci.}, title = {Ambient-pressure superconductivity onset at 10 k and robust tc under high pressure in TiNbTaN3 medium-entropy nitride}, volume = {12}, year = {2025}, }
• (2025). Chemigenetic encoding of fluorescent dyes enables high-fidelity and wash-free imaging of proteins in live cells. ADVS, 12(32), e05967. (www)

  @article{ , abstract = {Fluorescent dyes are indispensable chemical tools for protein labeling, yet their utility in live-cell imaging remains constrained by background fluorescence from off-target interactions. A chemigenetic strategy is presented that integrates synthetic dye chemistry with genetically encoded fluorescence to achieve high-fidelity, wash-free imaging of target proteins. By leveraging Förster resonance energy transfer (FRET) between fluorescent proteins (FPs) and Halo-tag dyes, a system is engineered where fluorescence emission depends on FPs donor excitation, ensuring only dyes bound to target protein are fluorescent, while nonspecifically bound dyes remain dark, enhancing the signal-to-noise ratio (SNR). This approach is implemented by fusing Halo-tag with FPs (sfGFP, mCherry) to create FRET pairs with Halo dyes ( O-Rho , Si-Rho ), yielding chemigenetic fluorophores (GLH-O, CLH-Si) with improved SNR even at low expression levels. By optimizing FRET efficiency, the developed probes CH-Si are combined with standard FPs and commercial dyes, and achieve four-color structured illumination microscopy (SIM) imaging of target proteins, and track the mitochondria interactions with endoplasmic reticulum, and lysosomes. Furthermore, by incorporating the ultra-stable mStayGold as donor, a photostable fluorophore (SLH-O) capable of long-term super-resolution imaging is developed. This versatile strategy combines chemical and genetic tools, offering a generalizable platform for high-precision studies of protein and cellular processes.}, archive = {J_ADVS}, author = {Xuelian Zhou and Lu Miao and Ning Xu and Yonghui Chen and Jinjing Shi and Jinhua Zhou and Guangying Wang and Qinglong Qiao and Zhaochao Xu}, doi = {10.1002/advs.202505967}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05967}, shortjournal = {Adv. Sci.}, title = {Chemigenetic encoding of fluorescent dyes enables high-fidelity and wash-free imaging of proteins in live cells}, volume = {12}, year = {2025}, }
• (2025). Bionic multimodal augmented somatosensory receptor enabled by thermogalvanic hydrogel. ADVS, 12(32), e05873. (www)

  @article{ , abstract = {The emergence of an e-skin receptor is an optimal solution for restoring the hand function of patients with sensation disorder, while constructing an e-skin receptor with high sensitivity, self-supervised capability, and open-environmental stability remains challenging. Here, inspired by the human skin perception mechanism, an ultrasensitive self-powered multimodal fingertip receptor that integrates thermogalvanic hydrogels as active mechanoreceptors and thermoreceptors for entropy-stabilized material fingerprint perception is proposed. A micropatterned and gradient structure strategy is introduced to improve the sensitivity to 53.6 kPa −1 with a low detection limit of 1.9 Pa. By exploiting static thermovoltage and dynamic differential signals to visualize the unsteady interfacial heat conduction, different materials can be determined in 80 ms based on the fast and slow adaptive sensations of the receptor. The self-supervised thermovoltage compensation is realized by self-decoupling contact pressure and thermal contact coefficients of materials, accommodating variations in applied forces. Benefiting from the robust interfacial heat transfer process and thermoelectric conversion, the tactile perception mechanism demonstrates universality under various external surroundings and contact conditions. With the assistance of deep learning, the fingertip receptor can function as an augmented somatosensory receptor to accurately perceive cutaneous cues of objects with an accuracy of 95.5%, which provides the potential of intelligent haptic perception to human-machine interfaces and prosthetics.}, archive = {J_ADVS}, author = {Ning Li and Zhaosu Wang and Yu Niu and Yu Li and Suyi Wen and Hulin Zhang and Zong-Hong Lin}, doi = {10.1002/advs.202505873}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05873}, shortjournal = {Adv. Sci.}, title = {Bionic multimodal augmented somatosensory receptor enabled by thermogalvanic hydrogel}, volume = {12}, year = {2025}, }
• (2025). DNA sequential logic circuits for reversible counters and dynamic biomolecular sensing. ADVS, 12(32), e05793. (www)

  @article{ , abstract = {The capacity to retain and precisely release historical data at the right moments is typically managed by sequential logic circuits within computer systems. However, the reusability and autonomy of DNA sequential logic circuits still need to be developed. To bridge this gap, a series of sequential logic circuits are implemented by constructing a DNA strand replacement system regulated by a nicking enzyme (nickase). This nickase-integrated system dynamically resolves the thermodynamic-kinetic conflict, offering spatiotemporal control over strand displacement. These circuits include Set-Reset latches (SR-latches) constructed with NOR and NAND gates, along with Data latches (D-latches), are designed with simplicity, autonomy, and reusability. Furthermore, addition, subtraction, and reversible counters leveraging these foundational circuits are successfully constructed. These latches are further applied to transient miRNA recording, environmental toxin detection, and real-time ATP imaging in living cells.}, archive = {J_ADVS}, author = {Tianci Xie and Changjiang Li and Minghao Hu and Xingyu Zhong and Junbin Xiao and Zhen Zhang and Ze Wang and Tongbo Wu}, doi = {10.1002/advs.202505793}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05793}, shortjournal = {Adv. Sci.}, title = {DNA sequential logic circuits for reversible counters and dynamic biomolecular sensing}, volume = {12}, year = {2025}, }
• (2025). Microenvironment engineering enables broad strategies for lithium-sulfur batteries. ADVS, 12(32), e05685. (www)

  @article{ , abstract = {Lithium-sulfur batteries (LSBs) are regarded as one of the most promising next-generation energy storage technologies due to their high energy density, abundant resource availability, and environmental sustainability. However, significant challenges, such as the lithium polysulfides shuttle effect and sluggish redox kinetics, impede their practical application. Microenvironment engineering provides innovative solutions to these issues by precisely controlling the physical and chemical environments of key components within LSBs. Despite the significance of this approach, there is a lack of systematic reviews on its application in the field of LSBs. This review fills the gap by comprehensively summarizing the research progress in microenvironment engineering for LSBs, focusing on four key aspects: 1) structural microenvironment engineering; 2) lithiophilicity microenvironment engineering; 3) sulfiphilicity microenvironment engineering; and 4) lithiophilicity-sulfiphilicity microenvironment engineering. These strategies are analyzed for their role in mitigating the challenges associated with LSBs. Finally, the research directions and the ongoing potential of the microenvironment engineering to drive further progress in this field are proposed for inspiring innovation and accelerating the practical application of LSBs in future.}, archive = {J_ADVS}, author = {Ranqi Li and Yingbo Xiao and Shaoming Huang}, doi = {10.1002/advs.202505685}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05685}, shortjournal = {Adv. Sci.}, title = {Microenvironment engineering enables broad strategies for lithium-sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). Bi-functional diaminopropane additive enables stable li anodes and highly efficient cathodes for high-performance li-air batteries. ADVS, 12(32), e05539. (www)

  @article{ , abstract = {Low round-trip efficiency and limited cycle durability remain significant challenges for commercial of Lithium-air batteries (LABs). This study introduces a novel electrolyte additive, diaminopropane (DAP), that simultaneously addresses anode stability and cathode reaction kinetics in ambient LABs. The proposed mechanism involves a bi-function approach: 1) at the anode, DAP spontaneously reacts with metallic Li to form Li-DAP, which subsequently cross-links with ether solvents to create a protective gel layer. This layer effectively mitigates Li dendrite formation and shields the anode from ambient moisture and CO 2 corrosion. 2) At the cathode, DAP modifies the oxygen reduction pathway from surface-mediated to solution-mediated, while simultaneously acting as an efficient redox mediator during charging. This dual functionality results in a remarkable reduction of the initial charging potential from 4.2 to 3.4 V, accompanied by observed singlet oxygen quenching. The implemented DAP additive enables LABs to achieve unprecedented cycling stability, demonstrating continuous operation for 1000 h in ambient air while maintaining energy efficiency exceeding 70%. This work establishes an effective electrolyte additive strategy for developing high-performance ambient LABs through simultaneous anode protection and enhanced cathode reaction reversibility.}, archive = {J_ADVS}, author = {Honghao Hu and Qingxu Zhang and Jiucong Liu and Junjie Li and Pingli Wu and Caicai Li and Peipei Du and Huiqiao Li and Xizheng Liu}, doi = {10.1002/advs.202505539}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05539}, shortjournal = {Adv. Sci.}, title = {Bi-functional diaminopropane additive enables stable li anodes and highly efficient cathodes for high-performance li-air batteries}, volume = {12}, year = {2025}, }
• (2025). Correction to “Inhibition of DEF-p65 interactions as a potential avenue to suppress tumor growth in pancreatic cancer”. ADVS, 12(32), e05440. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202505440}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05440}, shortjournal = {Adv. Sci.}, title = {Correction to “Inhibition of DEF-p65 interactions as a potential avenue to suppress tumor growth in pancreatic cancer”}, volume = {12}, year = {2025}, }
• (2025). Advances in medical devices for augmented acupuncture therapy. ADVS, 12(32), e05318. (www)

  @article{ , abstract = {Acupuncture, as a traditional medicine applied worldwide, is considered an effective treatment for numerous chronic diseases. Many researches have explored the biological mechanisms of acupuncture, including the skin-neuro-immune axis and inflammation-immune modulation. However, traditional acupuncture faces several limitations, such as its complex operation, the wide variety of acupoint combinations, long treatment durations, and susceptibility to individual differences between the practitioner and the patient. These challenges highlight the urgent need for intelligent medical devices that enable more precise and efficient modern acupuncture treatment. In response to this, this manuscript introduces engineered acupuncture needles (EANs) using techniques such as macroscopic mechanical etching, microscopic surface modification, and biomedical nanotechnology. These modified needles enhance acupuncture treatment by incorporating drug delivery, electrical stimulation, and thermal stimulation technologies. Here we provide an overview of recent advancements in EANs in terms of materials, fabrication methods, engineering technologies, acupoints, as well as disease models. The relevant bottlenecks and future prospects of their development are also discussed.}, archive = {J_ADVS}, author = {Ruisi Cai and Chenyi Yu and Xinyi Luo and Ningyu Xu and Jicheng Yu and Xiao Ye and Yuqi Zhang and Zhen Gu}, doi = {10.1002/advs.202505318}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05318}, shortjournal = {Adv. Sci.}, title = {Advances in medical devices for augmented acupuncture therapy}, volume = {12}, year = {2025}, }
• (2025). A wearable in-pad diagnostic for the detection of disease biomarkers in menstruation blood. ADVS, 12(32), e05170. (www)

  @article{ , abstract = {The pain-free monitoring of blood-based biomarkers is essential for early detection of diseases like cancers, infections, and metabolic disorders such as diabetes. While research often focuses on venous blood analysis, menstruation blood is an overlooked but promising source. Evidence shows a strong correlation between biomarker levels in menstruation and venous blood for many clinical analytes. A wearable, microfluidic monitoring platform integrated into hygiene pads is presented for electronic-free, naked-eye detection of disease biomarkers in menstruation blood (MenstruAI). Semi-quantitative detection of C-reactive protein (CRP), cancer biomarkers carcinoembryonic antigen (CEA) and cancer antigen 125 (CA-125), and endometriosis biomarker CA-125 is demonstrated. The biomarker-induced color changes can be read by the naked eye or a smartphone app with a machine-learning algorithm for semi-quantitative analysis. MenstruAI can revolutionize women's health by offering a non-invasive, affordable, and accessible health monitoring method, democratizing healthcare, and enhancing service availability and equity.}, archive = {J_ADVS}, author = {Lucas Dosnon and Thomas Rduch and Charlotte Meyer and Inge K. Herrmann}, doi = {10.1002/advs.202505170}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05170}, shortjournal = {Adv. Sci.}, title = {A wearable in-pad diagnostic for the detection of disease biomarkers in menstruation blood}, volume = {12}, year = {2025}, }
• (2025). A self-adaptive reconfigurable metasurface for electromagnetic wave sensing and dynamic reflection control. ADVS, 12(32), e05155. (www)

  @article{ , abstract = {In the past decade, reconfigurable metasurfaces have attracted significant attention. While existing reconfigurable metasurfaces require human intervention to switch functionalities, feature non-electromagnetic detection modalities or involve time-consuming and resource-intensive deep learning processes, in this work a simple real-time self-adaptive metasurface is reported that senses the direction of arrival of an incident wave, and adjusts its reflection accordingly. This proposed metasurface integrates sensing and reconfigurable reflection meta-atoms using a simple phase comparator and a lookup table. This eliminates auxiliary detection modalities and external controller units, achieving dramatic savings in response time, energy consumption and fabrication cost. As examples, we design and investigated metasurfaces which self-adaptively redirect or focus an incoming wave from any direction to a desired direction or location. It is experimentally demonstrated that the self-adaptive metasurface can reflect the incoming wave from any direction within ±50° to the normal reflection direction with great efficacy. Further, the metasurface self-adapts quickly, properly redirecting waves whose incidence angle changes by up to 12 deg/s with power consumption as low as 415 mW. Such metasurfaces provide an autonomous, computationally simple, cost-effective, energy efficient and real-time solution for a self-adaptive reflection control, and open exciting possibilities for wireless communication, radar sensing and related applications.}, archive = {J_ADVS}, author = {Bo-Wen Ren and Chu Qi and Peixing Li and Xiaoluo He and Alex M. H. Wong}, doi = {10.1002/advs.202505155}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05155}, shortjournal = {Adv. Sci.}, title = {A self-adaptive reconfigurable metasurface for electromagnetic wave sensing and dynamic reflection control}, volume = {12}, year = {2025}, }
• (2025). β-mangostin attenuates TET2-mediated DNA demethylation of prkcg in the prevention of intervertebral disc degeneration. ADVS, 12(32), e05077. (www)

  @article{ , abstract = {Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the global economy and healthcare systems. However, no effective disease-modifying therapies presently exist for IDD or its related pathologies. Single-cell sequencing analyses reveal progressive M1 macrophage polarization in NP cells correlating with IDD severity, underscoring the therapeutic imperative for dual-targeting agents addressing both inflammatory dysregulation and matrix homeostasis. β-mangostin (β_Man) is screened to be proven to possess potential therapeutic effects in alleviating IDD. β_Man possesses anti-inflammatory capabilities, which include remodeling the homeostasis of the extracellular matrix, regulating macrophage polarization, and inhibiting apoptosis in the nucleus pulposus. TET2-Prkcg exerts significant regulatory functions downstream of β_Man. Mechanically, β_Man mediated reduction of TET2 maintains the DNA methylation of Prkcg rather than hydroxymethylation, which promotes mitophagy and alleviates the inflammatory microenvironment. β_Man represents a promising novel therapeutic strategy for IDD treatment. The TET2-Prkcg axis emerges as a novel therapeutic target for IDD treatment.}, archive = {J_ADVS}, author = {Xiangzhen Kong and Hanwen Gu and Yuanqiang Zhang and Qunbo Meng and Qi Li and Kangle Song and Yanlin Li and Kaiwen Liu and Zhenchuan Liu and Rui Hu and Haoxi Zhai and Tian Li and Zemin Ling and Zhijian Wei and Fuxin Wei and Lei Cheng}, doi = {10.1002/advs.202505077}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05077}, shortjournal = {Adv. Sci.}, title = {β-mangostin attenuates TET2-mediated DNA demethylation of prkcg in the prevention of intervertebral disc degeneration}, volume = {12}, year = {2025}, }
• (2025). Advancements in DNA-driven precision modulation of cell surface receptor for programmable cellular functions. ADVS, 12(32), e05073. (www)

  @article{ , abstract = {Precise modulation of receptor-mediated signaling is essential for understanding cellular communication and developing targeted therapeutics. Receptor engineering strategies focus on enhancing specificity, manipulating allosteric effects, and controlling receptor clustering. This review comprehensively summarizes recent advances in DNA-based strategies as versatile platforms for receptor engineering, encompassing both genetic and non-genetic approaches. Genetic approaches leverage DNA's protein-coding capability to reprogram receptor function through techniques like domain fusion and site-directed mutagenesis. Complementarily, non-genetic strategies exploit the structural and functional properties of DNA to achieve multidimensional control over receptor functionalities. Specifically, functional nucleic acids (FNAs) confer novel and customizable molecular recognition responsiveness, while DNA nanostructures, such as DNA origami, provide nanoscale spatial precision for regulating receptor valency and oligomerization. Furthermore, programmable dynamic DNA reactions facilitate the development of nanodevices responsive to diverse stimuli, including proteins, small molecules, ions, light, and mechanical forces. Notably, emerging DNA-based logic circuits and nanorobots offer programmable and autonomous control over receptor signaling. Looking forward, integrating genetic and non-genetic DNA engineering strategies holds significant promise at the interface of synthetic biology and DNA nanotechnology, driving the development of next-generation intelligent cellular systems for precise medicine.}, archive = {J_ADVS}, author = {Hexin Nan and Ming Cai and Yiyu Wang and Hong-Hui Wang and Zhou Nie}, doi = {10.1002/advs.202505073}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e05073}, shortjournal = {Adv. Sci.}, title = {Advancements in DNA-driven precision modulation of cell surface receptor for programmable cellular functions}, volume = {12}, year = {2025}, }
• (2025). A generative AI-assisted piezo-MEMS ultrasound device for plant dehydration monitoring. ADVS, 12(32), e04954. (www)

  @article{ , abstract = {Plant health, closely tied to hydration, has a direct impact on agricultural productivity, making the monitoring of leaf water content essential. Current devices, however, are often invasive, bulky, slow, power-inefficient, Complementary Metal-Oxide-Semiconductor (CMOS)-incompatible, and unsuitable for large-scale, re-usable outdoor sensor networks. Utilizing micro-electromechanical systems (MEMS) fabrication enables wafer-scale miniaturization and precise control of ultrasound transducers, thereby enhancing sensitivity while significantly reducing power and cost. This work introduces the CMOS-compatible, plant-leaf attachable piezo-MEMS ultrasound device (PMUT-Leaf-PMUT, PLP) for real-time dynamic moisture monitoring and rapid one-shot measurement of relative water content (RWC). Notably, the PLP is reattachable to pre-calibrated plant leaves, enhancing reusability and reducing electronic waste. Employing piezoelectric micromachined ultrasound transducers (PMUTs) fabricated via piezoelectric over silicon-on-nothing (PSON), the device non-invasively monitors hydration across diverse cultivars with a 70% relative water content (RWC) detection range. Generative deep learning using a conditional variational autoencoder (CVAE) translates electrical signals to precise hydration measurements, achieving an RWC root-mean-square error of 1.25%. The deployment of this generative AI-assisted PLP system directly links plant responses to environmental shifts, representing a significant advancement in precision plant health management and irrigation practices, thereby substantially improving agricultural efficiency and promoting environmental conservation.}, archive = {J_ADVS}, author = {Kaustav Roy and Darren Sim and Luwei Wang and Zixuan Zhang and Xinge Guo and Yao Zhu and Sanjay Swarup and Chengkuo Lee}, doi = {10.1002/advs.202504954}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04954}, shortjournal = {Adv. Sci.}, title = {A generative AI-assisted piezo-MEMS ultrasound device for plant dehydration monitoring}, volume = {12}, year = {2025}, }
• (2025). Unconventional topological weyl dipole phonon. ADVS, 12(32), e04812. (www)

  @article{ , abstract = {A pair of Weyl points (WPs) with opposite topological charges can exhibit an additional higher-order Z 2 topological charge, giving rise to the formation of a Z 2 Weyl dipole (WD). Owing to the nontrivial topological charge, Z 2 WDs should also appear in pairs, and the WPs within each Z 2 WD can not be annihilated when meeting together. As a novel topological state, the topological Weyl dipole (TWD) phase has garnered significant attention, yet its realization in crystalline materials remains a challenge. Here, through first-principles calculations and theoretical analysis, the existence of the nontrivial unconventional WD phase is demonstrated in the phonon spectra of the P 6 3 type Y(OH) 3 . Particularly, the nontrivial unconventional WD in this system is protected by a quantized quadrupole moment, and it is distinguished from conventional WD, as it comprises an unconventional charge-3 WP with charge of –3 and three conventional charge-1 WPs with charge of +1. Consequently, the nontrivial unconventional WD phase in Y(OH) 3 features unique 2D sextuple-helicoid Fermi-arc states on the top and bottom surfaces, protected by the topological charges, as well as 1D hinge states that connect the two nontrivial unconventional WDs along the side hinges, guaranteed by the quantized quadrupole moment.}, archive = {J_ADVS}, author = {Jianhua Wang and Yang Wang and Feng Zhou and Wenhong Wang and Zhenxiang Cheng and Shifeng Qian and Xiaotian Wang and Zhi-Ming Yu}, doi = {10.1002/advs.202504812}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04812}, shortjournal = {Adv. Sci.}, title = {Unconventional topological weyl dipole phonon}, volume = {12}, year = {2025}, }
• (2025). O-GalNAc glycosylation activates MBL-mediated complement and coagulation cascades to drive organotropic metastasis. ADVS, 12(32), e04809. (www)

  @article{ , abstract = {Liver metastasis is prevalent among patients with neuroendocrine prostate cancer (NEPC) and other types of neuroendocrine (NE) cancers, featuring with an aggressive clinical course and a dismal prognosis. However, the cellular and molecular mechanisms underlying liver-specific metastatic tropism in NE cancers remain poorly understood. Intriguingly, it is found that NEPC liver metastatic foci are frequently associated with thrombi. NEPC cells express an aberrantly elevated level of glycosyltransferase Galnt9. Notably, the Galnt9-mediated O-GalNAc glycosylation on the cell membrane of NE cancer cells, particularly on the adhesion molecule Annexin A2, activates the mannose-binding lectin (MBL) complement signaling in the liver. This cascade stimulates platelet activation and thrombus formation, ultimately facilitating hepatic metastasis of NEPC. Inhibition of O-GalNAc glycosylation or knockdown of Galnt9 demonstrates efficacy in restraining the liver metastasis of NEPC, small cell lung cancer (SCLC), and colorectal neuroendocrine cancer. These findings identify Galnt9-mediated O-GalNAc glycosylation as a targetable mechanism driving liver metastasis through activation of MBL complement and coagulation cascades across a broad spectrum of NE cancers.}, archive = {J_ADVS}, author = {Xinyu Chen and Wei Bao and Kaiyuan Liu and Na Jing and Genyu Du and Luyao Jiang and Qian You and Yingchao Zhang and Penghui Xu and Chaping Cheng and Nan Wang and Xialian Xi and Mingyue Wang and Yiyun Liu and Jinming Wang and Huifang Zhao and Shilei Zhang and Dinglan Wu and Chi-Fai Ng and Jiahua Pan and Wei Xue and Wei-Qiang Gao and Pengcheng Zhang and Kai Zhang and Helen He Zhu}, doi = {10.1002/advs.202504809}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04809}, shortjournal = {Adv. Sci.}, title = {O-GalNAc glycosylation activates MBL-mediated complement and coagulation cascades to drive organotropic metastasis}, volume = {12}, year = {2025}, }
• (2025). Probiotic-enhanced porous bio-hybrids with inflammatory targeting, ROS scavenging, and long-term drug release for ulcerative colitis treatment. ADVS, 12(32), e04802. (www)

  @article{ , abstract = {Functional porous materials hold significant promise for biomedical applications owing to their high surface area and customizable pore architectures. However, the complex gastrointestinal environment poses considerable challenges for conventional nanomaterials in achieving targeted accumulation and controlled drug release. Herein, a kind of novel probiotic-enhanced porous bio-hybrids (E- x PAM@ASA) is designed via bio-hybridization of 5-aminosalicylic acid-loaded hairy microporous nanospheres ( x PAM@ASA) with probiotic Escherichia coli Nissle 1917. Benefiting from the intrinsic inflammatory-targeting capability of EcN, the E- x PAM@ASA can accumulate in the inflammatory sites of the intestine. The unique porous architecture of x PAM@ASA not only facilitates high drug loading and long-term release but also provides abundant adsorption sites for effective reactive oxygen species scavenging. In a dextran sulfate sodium-induced ulcerative colitis murine model, E- x PAM@ASA demonstrate superior therapeutic outcomes, including mucosal repair, inflammation alleviation, and microbiota regulation. These findings highlight the potential of the multifunctional nanocomposite as a precise therapeutic platform for the treatment of intestinal inflammation.}, archive = {J_ADVS}, author = {Luna Quan and Yang Ouyang and Weiwen Liang and Zixin Chen and Dongtian Miao and Bingna Zheng and Dingcai Wu and Rongkang Huang}, doi = {10.1002/advs.202504802}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04802}, shortjournal = {Adv. Sci.}, title = {Probiotic-enhanced porous bio-hybrids with inflammatory targeting, ROS scavenging, and long-term drug release for ulcerative colitis treatment}, volume = {12}, year = {2025}, }
• (2025). An in-depth study of the solid electrolyte interphase compositional evolution in sodium-ion batteries: Unravelling the effects of a na metal counter electrode on the SEI. ADVS, 12(32), e04717. (www)

  @article{ , abstract = {A comprehensive understanding of the solid electrolyte interphase (SEI) is crucial for ensuring long-term battery stability. This is particularly pertinent in sodium-ion batteries (NIBs), where the SEI remains poorly understood, and investigations are typically undertaken in half-cell configurations with sodium metal as the counter electrode. Na metal is known to be highly reactive with common carbonate-based electrolytes; nevertheless, its effects on SEI formation at the working electrode are largely unexplored. This work investigates the evolution of the SEI in NIBs during cycling, with an emphasis on the consequences of using a sodium metal counter electrode. Advanced analytical techniques, including hard X-ray photoelectron spectroscopy (HAXPES) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), are used to obtain depth-resolved insights into the chemical composition and structural changes of the SEI on hard carbon anodes during cycling. The findings demonstrate that the cell configuration has a significant impact on SEI evolution and, by extension, battery performance. These findings suggest that full-cell studies are necessary to better simulate practical operating conditions, challenging traditional half-cell experiments.}, archive = {J_ADVS}, author = {Jack R. Fitzpatrick and Beth E. Murdock and Pardeep K. Thakur and Tien-Lin Lee and Sarah Fearn and Andrew J. Naylor and Deepnarayan Biswas and Nuria Tapia-Ruiz}, doi = {10.1002/advs.202504717}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04717}, shortjournal = {Adv. Sci.}, title = {An in-depth study of the solid electrolyte interphase compositional evolution in sodium-ion batteries: Unravelling the effects of a na metal counter electrode on the SEI}, volume = {12}, year = {2025}, }
• (2025). Kinetically limited growth of dendritic tin oxide thin films: A machine learning study beyond the structure zone diagram. ADVS, 12(32), e04627. (www)

  @article{ , abstract = {Even after fifty years since its introduction, the empirical Thornton's structure zone diagram remains a valuable tool for predicting thin film microstructure. This diagram is essential for understanding the correlation between synthesis, composition, structure, and physical properties in emerging applications. In this work, we critically appraise this diagram by examining Sn─O thin films grown at room temperature using reactive magnetron sputtering. Based on transmission electron microscopy, Sn 0.6 O 0.4 thin films form dendrites featuring nanosized Sn and SnO grains, rather than columns, which are not captured by the structure zone diagram. Using density functional theory and machine learning, we constructed a model to explain this unusual microstructure on the atomic scale. Kinetically limited surface diffusion yields SnO islands on Sn(001), which constitute the initial stage of dendrite formation. This study provides the potential to devise models for thin film microstructure evolution, enhancing performance in advanced applications, such as green energy generation and storage.}, archive = {J_ADVS}, author = {Denis Music and Xuelian Xiao and Rami Naser and Keke Chang and Grzegorz Sadowski and Pär A. T. Olsson}, doi = {10.1002/advs.202504627}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04627}, shortjournal = {Adv. Sci.}, title = {Kinetically limited growth of dendritic tin oxide thin films: A machine learning study beyond the structure zone diagram}, volume = {12}, year = {2025}, }
• (2025). Diindolocarbazole as a core structure for narrow-emitting and highly efficient blue organic light-emitting diodes. ADVS, 12(32), e04625. (www)

  @article{ , abstract = {In this study, a molecular design approach inducing high efficiency and narrow emission in blue organic light-emitting diodes (OLEDs) using indolocarbazole and diindolocarbazole backbone structures are proposed. The indolocarbazole and diindolocarbazole backbone structures are used as a core structure and the indole is protected with spiro configured fluorene for rigidity and suppressed intermolecular interaction. The indolocarbazole and diindolocarbazole derived compounds show multiple resonance–thermally activated delayed fluorescence emission even without any electron deficient unit within the molecular structure and narrow emission spectrum with a full width at half maximum (FWHM) of less than 20 nm. As a result, the blue OLEDs fabricated using the unique diindolocarbazole emitter delivered high external quantum efficiency of 28.2% and a sharp emission spectrum with a FWHM of 20 nm.}, archive = {J_ADVS}, author = {Jihoon Kang and Junyoung Moon and Soon Ok Jeon and Unhyeok Jo and Seungwon Han and Sangmo Kim and Jun Yeob Lee}, doi = {10.1002/advs.202504625}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04625}, shortjournal = {Adv. Sci.}, title = {Diindolocarbazole as a core structure for narrow-emitting and highly efficient blue organic light-emitting diodes}, volume = {12}, year = {2025}, }
• (2025). A novel cranial bone transport technique repairs skull defect and minimizes brain injury outcome in traumatic brain injury rats. ADVS, 12(32), e04467. (www)

  @article{ , abstract = {TBI (traumatic brain injury) is a major cause of mortality and morbidity among young adults with limited therapeutic strategies. Cranial bone transport (CBT) technique is a safe, less invasive, and relatively simple surgical technique in bone reconstruction, which has been used to repair cranial bone defects and deformity corrections. The current studies are to determine the effects of CBT surgery on cranial bone regeneration as well as neurological functional recovery in TBI. CBT treatment alleviated lesion size and promoted learning, motor, and memory recovery in TBI rats. The meningeal lymphatic drainage function is enhanced, evidenced by increased intake of ovalbumin conjugated with Alexa Flour 647(OVA-A647) in meningeal lymphatic vessels (MLVs) and deep cervical lymph nodes (dCLNs). CBT accelerated P-tau clearance while decreasing Iba1 induced neuroinflammatory response in TBI rats. Notably, improvement of CBT treatment is significantly abolished by the ablation of MLVs via MAZ51, a small-molecule inhibitor primarily targeting vascular endothelial growth factor receptor-3 (VEGFR-3). Furthermore, after bone transport treatment, bone regeneration in the CBT sites continued consolidation, bone defects in TBI are replaced with new bone more quickly after CBT surgery. Taken together, the study is a proof-of-concept de-novo study to prove CBT can significantly improve the outcomes of brain recovery and cranioplasty in TBI rats.}, archive = {J_ADVS}, author = {Shanshan Bai and Xuan Lu and Xu Yan and Han Su and Yuejun Lin and Zhaowei Jiang and Zhixian Zong and Haixing Wang and Leo Yik Chun Yan and Xiaoting Zhang and Ming Wang and Zhengmeng Yang and Jiakang Jin and Yaofeng Wang and Wayne Yuk-Wai Lee and Xiaohua Jiang and Ho Ko and Lu Feng and Micky D. Tortorella and Sien Lin and Gang Li}, doi = {10.1002/advs.202504467}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04467}, shortjournal = {Adv. Sci.}, title = {A novel cranial bone transport technique repairs skull defect and minimizes brain injury outcome in traumatic brain injury rats}, volume = {12}, year = {2025}, }
• (2025). Critical electrochemistry technologies applicable in space exploration. ADVS, 12(32), e04447. (www)

  @article{ , abstract = {Electrochemistry is versatile, less subject to external influences, and has great potential for the exploration of the unpredictable space environment. This work analyzes the available resources in space and discusses the application scenarios and challenges of electrochemical methods in four areas: metallurgical processing of mineral resources, water resources utilization, the carbon cycle in daily extraterrestrial life, and electrical energy storage. By examining these pivotal areas, this work elucidates the unique advantages and limitations of electrochemical technologies in space exploration. Furthermore, the paper explores the innovative application scenarios of electrochemistry in space, presenting fresh insights into how these technologies can be adapted and optimized for extraterrestrial environments. This comprehensive analysis not only provides a strategic direction for the breakthrough and advancement of electrochemical applications in space but also serves as an invaluable reference for the development of human extraterrestrial exploration and resource harvesting programs, guiding future research endeavors and technological innovations in this fascinating frontier.}, archive = {J_ADVS}, author = {Ruisi Xu and Zepeng Lv and Shaolong Li and Jilin He and Jianxun Song}, doi = {10.1002/advs.202504447}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04447}, shortjournal = {Adv. Sci.}, title = {Critical electrochemistry technologies applicable in space exploration}, volume = {12}, year = {2025}, }
• (2025). Symmetry breaking of molecules triggered by chiral inorganic nanostructures without organic components. ADVS, 12(32), e04269. (www)

  @article{ , abstract = {Chirality transfer has garnered significant attention due to its potential to revolutionize asymmetric synthesis of enantiopure compounds and to provide fundamental insights into molecular symmetry breaking, which is widely believed to underlie the pervasive phenomenon of homochirality in biological systems. While organic-to-organic and organic-to-inorganic chirality transfers have been extensively studied, the inorganic-to-organic counterpart remains challenging due to the dimensional mismatch between the nanoscale of inorganic materials and the molecular scale of organic compounds, the thermodynamic instability of chiral inorganic lattices, and the uncontrollable influence of defects on chirality transfer. This review summarizes the synthesis of organic-free chiral nano-inorganic materials and explores the concept of inorganic-to-organic chirality transfer via symmetry breaking induced by these materials through three proposed pathways: enantiospecific inorganic–organic interactions, chirality transfer from circularly polarized light to molecules, electron spin-determined enantiopreferential reactions governed by chiral-induced spin selectivity. Inorganic-to-organic chirality transfer via symmetry breaking offers a novel framework for investigating spin chemistry, advancing asymmetric synthesis, enabling enantioselective production of single-enantiomer pharmaceuticals, and elucidating the origin of homochirality on prebiotic Earth.}, archive = {J_ADVS}, author = {Tao Yao and Xiao Chen and Yating Fang and Zhifeng Huang}, doi = {10.1002/advs.202504269}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04269}, shortjournal = {Adv. Sci.}, title = {Symmetry breaking of molecules triggered by chiral inorganic nanostructures without organic components}, volume = {12}, year = {2025}, }
• (2025). Recyclable li-metal battery electrolytes via in situ cyclic carbonate polymerization. ADVS, 12(32), e04206. (www)

  @article{ , abstract = {Enabling recycling and improving performance are key challenges for next-generation electrolytes for rechargeable batteries. Here, an equilibrium polymerization: trimethylene carbonate (TMC) ring-opening polymerization, in the presence of lithium difluoro(oxalato)borate salt, is utilized to form an electrolyte in situ during coin cell fabrication for lithium batteries. This process creates a semi-solid poly(trimethylene carbonate) electrolyte with high ambient ionic conductivity (0.52 mS cm −1 ), thermal stability ( T d, 5% = 160 °C), and oxidative stability up to 4.7 V. Using this electrolyte with commercial lithium iron phosphate cathodes, results in 97% capacity retention after 350 cycles at 2C, achieving theoretical capacities of 170 mAh g −1 at 0.1C. The cells retain excellent performance at high current densities (86 mAh g −1 at 4C). Post-use, the polymer can be separated from the salt and selectively recycled to pure starting monomer (TMC) through a solid-state chemical recycling process. The recycled monomer, when repolymerized to reform the polycarbonate electrolyte, yields cells with performance identical to the original. The exploitation of polymerization-depolymerization equilibria offers a useful strategy for enhancing battery performance, ensuring effective material recycling, and advancing a circular economy.}, archive = {J_ADVS}, author = {Hui Gao and Victor Riesgo-Gonzalez and James R. Runge and Kanyapat Yiamsawat and Dominic Spencer-Jolly and Thomas M. McGuire and Gregory J. Rees and Xiangwen Gao and Bingkun Hu and Shengming Zhang and Longlong Wang and Peter G. Bruce and Georgina L. Gregory and Charlotte K. Williams}, doi = {10.1002/advs.202504206}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04206}, shortjournal = {Adv. Sci.}, title = {Recyclable li-metal battery electrolytes via in situ cyclic carbonate polymerization}, volume = {12}, year = {2025}, }
• (2025). EFTUD2 regulates cortical morphogenesis via modulation of caspase-3 and aifm1 splicing pathways. ADVS, 12(32), e04200. (www)

  @article{ , abstract = {Elongation Factor Tu GTP-Binding Domain Containing 2 (EFTUD2), a core spliceosomal GTPase associated with Mandibulofacial Dysostosis with Microcephaly (MFDM), plays a mechanistically undefined role in cerebral development. To investigate its pathophysiological contributions, murine models are generated through conditional Eftud2 ablation and in utero electroporation of human pathogenic EFTUD2 variants into cortical neural stem cells (NSCs). Embryonic NSC-specific Eftud2 knockout resulted in cortical disorganization and microcephaly, while pathogenic variants led to significant neuronal loss. Integrative transcriptomic and immunofluorescence analyses revealed that Eftud2 deficiency triggers apoptotic pathways, contributing to cortical malformations. Mechanistic studies using RNA co-immunoprecipitation and full-length transcriptome sequencing demonstrated that Eftud2 directly interacts with Caspase3 and Aifm1 transcripts, regulating their alternative splicing to generate pro-apoptotic isoforms. Splicing assays functionally validated this regulatory mechanism, showing its role in activating cell death pathways and disrupting neurodevelopmental homeostasis. These findings elucidate EFTUD2's critical role in maintaining apoptotic balance during corticogenesis and identify defective splicing regulation as the molecular basis of MFDM. This study provides insights for advancing diagnostic frameworks and therapeutic strategies for neurodevelopmental disorders.}, archive = {J_ADVS}, author = {Liping Chen and Ying Li and Yan Yu and Mingze Cai and Hao Li and Minghe Huang and Guochao Yang and Jiageng Guo and Huailin Wang and Zhihong Song and Wei Shen and Huihui Jiang and Haitao Wu}, doi = {10.1002/advs.202504200}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04200}, shortjournal = {Adv. Sci.}, title = {EFTUD2 regulates cortical morphogenesis via modulation of caspase-3 and aifm1 splicing pathways}, volume = {12}, year = {2025}, }
• (2025). Copper-based nanotubes that enhance starvation therapy through cuproptosis for synergistic cancer treatment. ADVS, 12(32), e04121. (www)

  @article{ , abstract = {Hepatic cancer is the leading cause of worldwide death due to lack of effective chemotherapy drugs. Cuproptosis is a novel regulated cell death and offers a new potential mechanism to eliminate hepatic cancer. In this study, it is found that hepatocellular carcinoma (HCC), which is one of the hepatic cancer, is sensitive to cuproptosis by analysing clinical specimens and databases. Thus, a copper-based nanotube (NT) with copper ionophores to induce enhanced cuproptosis is designed. In combination with starvation therapy, the NT significantly inhibited energy metabolism in HCC cells. This results show that the depletion of GSH by Cu 2+ intensified oxidative stress and cuproptosis, resulting in ROS generation and DLAT aggregation, indicating the enhancement of cuproptosis and the Fenton reaction. The NT with synergetic cuproptosis, the Fenton reaction and starvation therapy provide a valuable insight into the prospect of HCC treatment.}, archive = {J_ADVS}, author = {Xuan Han and Xin Zhang and Zhiping Liu and Hang Liu and Derek Wu and Yinli He and Kexin Yuan and Yi Lyu and Xiaofei Liu}, doi = {10.1002/advs.202504121}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e04121}, shortjournal = {Adv. Sci.}, title = {Copper-based nanotubes that enhance starvation therapy through cuproptosis for synergistic cancer treatment}, volume = {12}, year = {2025}, }
• (2025). Shifting acetylene hydrochlorination from the gas to the liquid phase: Vinyl chloride production in bichloride-based ionic liquids. ADVS, 12(32), e03992. (www)

  @article{ , abstract = {Herein, [NEt 3 Me] 2 [PdCl 4 ] is reported as a highly active catalyst for the mercury-free hydrochlorination of acetylene to vinyl chloride, resulting from the combination of the bichloride-based ionic liquid [NEt 3 Me][Cl(HCl) n ] with PdCl 2 . Replacing gaseous HCl with the bichloride shifts the reaction in the liquid phase increasing the process safety by pressure reduction and achieves a turnover frequency of TOF = 110 mol VCM h −1 mol PdCl2 −1 matching the productivity of state-of-the-art heterogeneous systems. Additionally, [NEt 3 Me] 2 [PdCl 4 ] shows remarkable long-term stability and can be re-used over ten reaction cycles (200 h in total) without any problems due to its resistance to reduction by acetylene and coking as revealed by kinetic, theoretical, and spectroscopic investigations. Finally, initial catalytic studies demonstrate promising outcomes for applications of the bichloride-based ionic liquids with other noble metals, like platinum, if disproportionation phenomena, as observed for gold, do not occur.}, archive = {J_ADVS}, author = {Gesa H. Dreyhsig and Vera Giulimondi and Merlin Kleoff and Letizia Lanfredi and Maxim Fuchs and Niklas Limberg and Marc Reimann and Martin Kaupp and Javier Pérez-Ramírez and Sebastian Riedel}, doi = {10.1002/advs.202503992}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03992}, shortjournal = {Adv. Sci.}, title = {Shifting acetylene hydrochlorination from the gas to the liquid phase: Vinyl chloride production in bichloride-based ionic liquids}, volume = {12}, year = {2025}, }
• (2025). Mechanical and electrical properties of free-standing polycrystal diamond membranes. ADVS, 12(32), e03986. (www)

  @article{ , abstract = {In this study, we demonstrate a novel approach for synthesizing free-standing and transferable polycrystalline diamond membranes (PCDm) to overcome these constraints, thus enabling a much wider spectrum of applications. Two types of PCDm cantilevers —Top-Surface-Up (TSU) and Bottom-Surface-Up (BSU) are fabricated, each with two different sets of dimensions: 150 µm (width) × 1200 µm (length) and 300 µm (width) × 2000 µm (length). Their mechanical and electrical properties are systematically investigated. Atomic Force Microscopy (AFM) analysis revealed that TSU-PCDm has a higher elastic modulus than BSU-PCDm, attributed to differences in grain size and defect distribution. Despite these differences, all PCDms in our work exhibit consistently high modulus values with minimal mechanical degradation across various cantilever geometries. Bandgap measurements using X-ray Photoelectron Spectroscopy (XPS) and UV–vis absorption spectroscopy indicated a lower bandgap for TSU-PCDm due to boron incorporation, while BSU-PCDm exhibited a higher bandgap due to increased hydrogen content. Electrical characterization showed that the sheet resistance of TSU-PCDm decreases under strain, whereas BSU-PCDm maintains stable resistance. These findings unveil the material properties of PCDm and their potential usage for myriad diamond-based electronic applications.}, archive = {J_ADVS}, author = {Chenyu Wang and Dmitry Shinyavskiy and Luke Suter and Zubaida Altikriti and Quanxi Jia and Matthias Muehle and Jung-Hun Seo}, doi = {10.1002/advs.202503986}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03986}, shortjournal = {Adv. Sci.}, title = {Mechanical and electrical properties of free-standing polycrystal diamond membranes}, volume = {12}, year = {2025}, }
• (2025). Subgenome dominance in allotetraploid actinidia valvata regulates RNA m6A modification for waterlogging tolerance. ADVS, 12(32), e03974. (www)

  @article{ , abstract = {Polyploidization is a major driving force for evolutionary innovation and environmental adaptation in plants and is notably prevalent in kiwifruits. However, the molecular mechanisms through which subgenome interactions influence vigor and stress resilience remain largely unclear. Here, the high-quality genome of the tetraploid kiwifruit Actinidia valvata , which exhibits strong waterlogging tolerance compared to cultivated varieties is reported. The analysis reveals that the polyploid genome is of hybrid origin and exhibits subgenome dominance. The enhanced gene expression in the dominant subgenome is accompanied by fewer transposable elements, lower DNA methylation levels, increased chromatin accessibility, and biased global RNA m 6 A methylation abundance and distribution. It is demonstrated that this dominance is established, in part, prior to polyploidization. The dominant subgenome is transcriptionally more responsive to waterlogging stress, consistent with the fact that its putative progenitor is also waterlogging tolerant, affirming the significant role of the dominant subgenome in mediating waterlogging tolerance in A. valvata . Furthermore, inhibition of RNA m 6 A methylation in A. valvata roots enhances their activity under waterlogging stress, while waterlogging modulates m 6 A modifications, particularly in the dominant subgenome, affecting genes known to be involved in waterlogging responses. These findings reveal that subgenome dominance in A . valvata operates through multiple regulatory mechanisms, collectively endowing the polyploid with unique traits inherited from its progenitors.}, archive = {J_ADVS}, author = {Xiaoli Hu and Changbin Xu and Xiaolan Li and Lin Li and Yu Bao and Miaofeng Gu and Xinyi Li and Liuqing Huo and Jinli Gong and Xiaolong Li and Minhui Wang and Kai Xu and Xueren Yin and Zhangjun Fei and Xuepeng Sun}, doi = {10.1002/advs.202503974}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03974}, shortjournal = {Adv. Sci.}, title = {Subgenome dominance in allotetraploid actinidia valvata regulates RNA m6A modification for waterlogging tolerance}, volume = {12}, year = {2025}, }
• (2025). Symmetry breaking in meniscus splitting: Effects of boundary conditions and polymeric membrane growth. ADVS, 12(32), e03807. (www)

  @article{ , abstract = {An evaporative interface creates a non-equilibrium state for both dissolved molecules and geometrically asymmetric macrostructures such as those involved in crystal growth. The phenomenon of meniscus splitting has been discovered and hydrodynamically demonstrated using a Hele–Shaw cell by drying a viscous polymer solution/dispersion. The generation of multiple nuclei has been reported; however, the relative nuclei positions and dominant factors remain unclear. This study investigates meniscus splitting involving multiple nucleation events, focusing on symmetry breaking and asynchronous nucleus formation. Fundamentally, it is found that rather than splitting into halves or thirds, the splitting is uneven. With the cell width setting the boundary conditions, the nucleus is not generated at the center of the cell width, but rather is shifted to an asymmetric position, as shown by the statistical analysis of the nuclei positions. The shift strongly facilitates asynchronous second nucleation. Such deviations from symmetry and synchrony are crucial for interpreting dissipative structures and their time evolution.}, archive = {J_ADVS}, author = {Thi Kim Loc Nguyen and Taisuke Hatta and Koji Ogura and Yoshiya Tonomura and Kosuke Okeyoshi}, doi = {10.1002/advs.202503807}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03807}, shortjournal = {Adv. Sci.}, title = {Symmetry breaking in meniscus splitting: Effects of boundary conditions and polymeric membrane growth}, volume = {12}, year = {2025}, }
• (2025). Revealing dynamic ion transport in tailorable carbon nano-skyscraper electrodes. ADVS, 12(32), e03749. (www)

  @article{ , abstract = {Optimizing ion transport dynamics in nanoporous electrodes is crucial for advancing electrochemical energy storage and conversion technologies. However, rapid charge relaxation and architectural complexity in conventional electrodes impede a comprehensive understanding of ionic behavior. Here, convoluted ion migration routes are decoupled into two distinct pathways by precisely engineering the density and spatial arrangement of 3D carbon-interconnected nanoporous architectures. The findings reveal that ions exhibit time-optimized transport, prioritizing pathways that minimize temporal resistance over shorter spatial distances. This behavior, enabled by rational electrode design, enhances the performance of quasi-ideal (low-curvature) electrodes by 20% at ultrahigh scan rates of 1 0000 mV s −1 . Through finite element simulations and experimental validation, it is further demonstrated that uniformly distributed nanoporous configurations outperform localized and gradient designs in charging dynamics. These insights provide a framework for designing high-efficiency nanoporous electrodes, with significant implications for next-generation electrochemical devices.}, archive = {J_ADVS}, author = {Jiye Li and Xiaoyang Zheng and Luting Zhu and Yihang Yao and Sisi Yan and Lang Wang and Jing He and Chen Zhao and Ziqian Zhou and Liaoyong Wen}, doi = {10.1002/advs.202503749}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03749}, shortjournal = {Adv. Sci.}, title = {Revealing dynamic ion transport in tailorable carbon nano-skyscraper electrodes}, volume = {12}, year = {2025}, }
• (2025). Ferrocene-functionalized black phosphorus nanoplatform enables targeted and prolonged MRI visualization of atherosclerotic plaques. ADVS, 12(32), e03654. (www)

  @article{ , abstract = {Despite the critical role of contrast-enhanced magnetic resonance imaging (MRI) in clinical diagnostics, current contrast agents face dual challenges: metallic formulations provoke biosafety concerns while organic radicals exhibit transient imaging windows. To overcome these limitations, a radical-engineered 2D black phosphorus (2D BP) nanoplatform is reported through atomic-scale conjugation of aminoferrocene, creating a stable complex with enhanced electron spin resonance, named FcP. The covalent coupling strategy establishes persistent T 2 -weighted contrast capability. Subsequent hyaluronic acid (HA) functionalization endows the HA-FcP system with CD44-specific targeting, achieving 1.7-fold higher plaque accumulation than non-targeted counterparts in apolipoprotein E-deficient models. Remarkably, this nanostructure enables continuous MRI visualization of atherosclerotic lesions for 120 h post-injection. Systematic biosafety evaluation demonstrates >90% cell viability and normal hematological parameters. This work pioneers a new paradigm for MRI contrast agents through spin state manipulation of 2D materials, providing a translational platform for precision cardiovascular diagnostics.}, archive = {J_ADVS}, author = {Xiao Huang and Yuanyuan Zhao and Miao Zhou and Yukang Guo and Haiyun Wang and Yuanyuan Chen and Jian Peng}, doi = {10.1002/advs.202503654}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03654}, shortjournal = {Adv. Sci.}, title = {Ferrocene-functionalized black phosphorus nanoplatform enables targeted and prolonged MRI visualization of atherosclerotic plaques}, volume = {12}, year = {2025}, }
• (2025). A two-component pseudo-icosahedral protein nanocompartment with variable shell composition and irregular tiling. ADVS, 12(32), e03617. (www)

  @article{ , abstract = {Protein shells or capsids are a widespread form of compartmentalization in nature. Viruses use protein capsids to protect and transport their genomes while many cellular organisms use protein shells for varied metabolic purposes. These protein-based compartments often exhibit icosahedral symmetry and consist of a small number of structural components with defined roles. Encapsulins are a prevalent protein-based compartmentalization strategy in prokaryotes. All encapsulins studied thus far consist of a single shell protein that adopts the viral Hong Kong 97 (HK97)-fold. Here, the characterization of a Family 2B two-component encapsulin from Streptomyces lydicus is reported. The differential assembly behavior of the two shell components and their ability to co-assemble into mixed shells with variable shell composition is demonstrated. The structures of both shell proteins are determined using cryo-electron microscopy. Using 3D-classification and cross-linking studies, the irregular tiling of mixed shells is highlighted. This work expands the known assembly modes of HK97-fold proteins and lays the foundation for future functional and engineering studies on two-component encapsulins.}, archive = {J_ADVS}, author = {Cassandra A. Dutcher and Michael P. Andreas and Tobias W. Giessen}, doi = {10.1002/advs.202503617}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03617}, shortjournal = {Adv. Sci.}, title = {A two-component pseudo-icosahedral protein nanocompartment with variable shell composition and irregular tiling}, volume = {12}, year = {2025}, }
• (2025). Lipid droplet-organized MDM2-mediated p53 degradation: A metabolic switch governing diet-driven tumor progression. ADVS, 12(32), e03473. (www)

  @article{ , abstract = {TP53 inactivation in human cancers often results from MDM2/MDMX overexpression, yet therapeutic targeting remains challenging owing to incomplete mechanistic understanding. Lipid droplet (LD) enrichment is identified as a key trigger for MDM2-mediated p53 degradation. High-fat diet (HFD)-induced LD accumulation in tumor cells elevates LD-surface MDM2 through Cyb5r3-Myh9 interactions, which recruit cytoplasmic p53/Myh9 complexes to LDs. This spatial proximity enhances MDM2-p53 binding, accelerating its ubiquitination and proteasomal degradation. Degraded p53 releases the RPS3A-C/EBPβ complex, upregulating LD-promoting factors such as CD36 to establish a cell-autonomous feed-forward loop. Critically, pharmacological LD reduction (via lipogenesis inhibitors) or switching of tumor-bearing mice from an HFD to a normal diet restores p53 levels and suppresses tumor growth. These findings delineate a lipid-driven regulatory axis in which LD biogenesis initiates MDM2-dependent p53 destruction, reshaping tumor cell lipid metabolism. This mechanism links dietary lipids to oncogenesis through organelle-specific protein trafficking and provides a therapeutic rationale for targeting lipid metabolism in tumors. This study resolves critical gaps in p53 regulation while proposing dual intervention strategies: disrupting LD-MDM2 colocalization and modulating lipid availability.}, archive = {J_ADVS}, author = {Haiyang Liu and Lin Jing and Yixin Li and Jinxing Zhou and Xiaohui Cui and Sen Li and Shijie Yang and Fangming Kan and Junfeng Du and Wentao Zhong and Sheng Yu and Ning Wang and Xing Jia and Junhui Li and Pan Nie and Zhenzhong Chen and Ying Han and Lingxi Jiang and Xiyun Yan and Hongxia Duan and Baiyong Shen}, doi = {10.1002/advs.202503473}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03473}, shortjournal = {Adv. Sci.}, title = {Lipid droplet-organized MDM2-mediated p53 degradation: A metabolic switch governing diet-driven tumor progression}, volume = {12}, year = {2025}, }
• (2025). Cascade promotion of gas separation performances in CMS membranes: MOFs with functional groups and loaded noble metals. ADVS, 12(32), e03471. (www)

  @article{ , abstract = {The rational design of precursor structure serves as a critical determinant for the pore geometry and gas separation performance of carbon molecular sieve (CMS) membranes. Herein, a novel mixed-matrix CMS (MMCMS) membrane was fabricated via a palladium-doped carboxyl-functionalized UiO-66 (Pd/UiO66-COOH)/polyimide (PI) MMM precursor. On one hand, the decomposition of -COOH groups generates abundant micropores, meanwhile the decarboxylation-induced thermally cross-linking enhances the stability of the carbon framework, thus mitigating the collapse of micropores during carbonization and consequently improving H 2 and CO 2 permeability, as well as membrane stability; on the other hand, the synergistic effect of decarboxylation-induced thermally cross-linking and the catalytic graphitization effects of Pd nanoparticles facilitated the formation of more ordered Langmuir domains and narrowed carbon interlayer spacing, thereby enhancing molecular sieving effects. In addition, Pd nanoparticles also contribute to providing abundant H 2 adsorption sites to facilitated transport of H 2 gases. Specifically, the PI/Pd-UiO66-COOH-5-550 MMCMS membrane exhibited superior H 2 permeability of 9134.6 Barrer (P CO2 = 4033.4 Barrer) with H 2 /CH 4 selectivity of 118.5 (α CO2/CH4 = 52.3), exceeding the latest Robeson upper bound. Furthermore, the membrane also demonstrated attractive aging resistance, retaining over 90% of its initial H 2 and CO 2 permeability after a 21-day long-term stability test.}, archive = {J_ADVS}, author = {Min Deng and Jing Wei and Jundong Guo and Zikang Qin and Jia Song and Junfeng Zheng and Lin Yang and Lu Yao and Wenju Jiang and Xiaohua Ma and Xuezhong He and Jiadai He and Jianjian Wang and Zhongde Dai}, doi = {10.1002/advs.202503471}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03471}, shortjournal = {Adv. Sci.}, title = {Cascade promotion of gas separation performances in CMS membranes: MOFs with functional groups and loaded noble metals}, volume = {12}, year = {2025}, }
• (2025). In situ light-modulation of capacity and impedance in lithium-ion batteries. ADVS, 12(32), e03340. (www)

  @article{ , abstract = {The in situ regulation of capacity and impedance presents a significant challenge that impedes the application of lithium-ion batteries (LIBs). Herein, a novel strategy is introduced that utilizes a broadband light-modulated method for in situ manipulation of cell capacities and impedances. This approach leverages a photoconductive heterojunction comprising cadmium sulfide (CdS) nanorod arrays and a reduced graphene oxide (rGO) film. The heterostructure efficiently responds to a broad light spectrum, including UV to visible wavelengths. The results show that for the CdS/rGO anode, under conditions of UV exposure and absence of illumination, the capacity varies between 275 and 450 mAh g −1 after 200 cycles at 0.2 A g −1 , and the impedance changes from 1205 to 261 Ω, respectively. When applied to a full-cell, the capacity and impedance of the full-cell can still be controlled by light intensity and light type. The facts suggest that by constructing light-modulated devices, in situ modulation of battery capacity and impedance can be successfully achieved, facilitating the application of LIBs in complex scenarios. This important innovation offers a novel approach to battery design and holds immense potential for developing safer and more efficient energy storage systems.}, archive = {J_ADVS}, author = {Hong Yin and Xiangxiang Yu and Yucan Zhu and Zhaohui Hou and Joao Cunha and Zhenxing Liang and Zhipeng Yu}, doi = {10.1002/advs.202503340}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03340}, shortjournal = {Adv. Sci.}, title = {In situ light-modulation of capacity and impedance in lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Embodying control in soft multistable robots from morphofunctional co-design. ADVS, 12(32), e03206. (www)

  @article{ , abstract = {Soft robots are distinguished by their flexibility and adaptability, allowing them to perform nearly impossible tasks for rigid robots. However, controlling their behavior is challenging due to their nonlinear material response and infinite degrees of freedom. A potential solution to these challenges is to discretize their infinite-dimensional configuration space into a finite but sufficiently large number of functional modes with programmed dynamics. A strategy is presented for co-designing the desired tasks and morphology of pneumatically actuated soft robots with multiple encoded stable states and dynamic responses. This approach introduces a general method to capture the soft robots' response using an energy-based analytical model, the parameters of which are obtained using Recursive Feature Elimination. The resulting lumped-parameter model enables the inverse co-design of the robot's morphology and planned tasks by embodying specific dynamics upon actuation. This approach's ability to explore the configuration space is shown by co-designing kinematics with optimized stiffnesses and time responses to obtain robots capable of classifying the size and weight of objects and displaying adaptable locomotion with minimal feedback control. This strategy offers a framework for simplifying the control of soft robots by exploiting the mechanics of multistable structures and embodying mechanical intelligence into soft material systems.}, archive = {J_ADVS}, author = {Juan C. Osorio and Jhonatan S. Rincon and Harith Morgan and Andres F. Arrieta}, doi = {10.1002/advs.202503206}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03206}, shortjournal = {Adv. Sci.}, title = {Embodying control in soft multistable robots from morphofunctional co-design}, volume = {12}, year = {2025}, }
• (2025). Wide-temperature electrolyte design via cation-anion solvation engineering for 4.6 v lithium-ion batteries. ADVS, 12(32), e03151. (www)

  @article{ , abstract = {Conventional lithium-ion batteries (LIBs) employing ethylene carbonate (EC)-based electrolytes and thermally unstable LiPF 6 face dual challenges: sluggish Li-ion transport at low temperatures (≤−20 °C) and severe decomposition at elevated temperatures (≥45 °C). Herein, a synergistic cation-anion solvation engineering strategy is presented for wide-temperature electrolytes, combining EC-free carbonate solvents with a thermally stable ternary lithium salt system. By fine-tuning solvent-salt interactions, the designed electrolyte exhibits facilitated desolvation kinetics and superior ionic conductivity under subzero temperatures (0.19 mS cm −1 at −60 °C), while also maintaining excellent high-temperature stability. The anion-participated solvation structure induces an inorganic-rich cathode-electrolyte interphase (CEI), effectively stabilizing the interfacial phase of LiCoO 2 (LCO) under high voltages. Consequently, the LCO cathode with this electrolyte demonstrates robust performance under wide-temperature operations. At 4.6 V (versus Li/Li + ), it retains 88.9% of its capacity after 400 cycles at 25 °C and 77.3% after 200 cycles at 45 °C. Remarkably, a reversible capacity of 110.1 and a discharge capacity of 92.6 mAh g −1 are delivered at −35 and −60 °C, respectively, highlighting its exceptional performance under extreme temperatures. This research pioneers a cation-anion solvation design for tailored electrolytes, enabling reliable LIB operation across a wide temperature range.}, archive = {J_ADVS}, author = {Hao Zhang and Yan Zhao and Xiangrong Li and Haoliang Wang and Lu Wang and Yongli Song and Fen Qiao and Junfeng Wang and Jijian Xu}, doi = {10.1002/advs.202503151}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03151}, shortjournal = {Adv. Sci.}, title = {Wide-temperature electrolyte design via cation-anion solvation engineering for 4.6 v lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Mitochondrial regulation of CD8⁺ t cells: Mechanisms and therapeutic modulation. ADVS, 12(32), e03095. (www)

  @article{ , abstract = {Mitochondria are integral to the regulation of CD8 + T cell function, critically influencing processes such as activation, differentiation, and long-term persistence during immune responses. Emerging evidence highlights the detrimental impact of mitochondrial dysfunction on CD8 + T cell activity, contributing to immune exhaustion and impairing both antitumor and antiviral immunity. This underscores the importance of understanding and modulating mitochondrial dynamics to optimize T cell-based immunotherapies. In this review, a comprehensive and in-depth analysis of the essential mitochondrial processes—including biogenesis, redox homeostasis, and metabolic reprogramming is provided—that govern CD8 + T cell function and are intricately linked to their therapeutic potential. The current strategies aimed at enhancing mitochondrial function in CD8 + T cells are also examined, focusing on both metabolic reprogramming and mitochondrial-targeted interventions. Despite these promising approaches, several significant challenges remain, such as achieving selective targeting, addressing mitochondrial plasticity, and mitigating off-target effects. Overcoming these obstacles will be crucial to improving the clinical efficacy and safety of mitochondrial modulation therapies. As the understanding of mitochondrial dynamics within CD8 + T cells continues to evolve, there is growing potential to leverage these insights to improve immune-based therapies across a range of diseases, including cancer and viral infections.}, archive = {J_ADVS}, author = {Xu Chen and Pei Lin and Ye Lu and Jiarong Zheng and Yunfan Lin and Zihao Zhou and Li Cui and Xinyuan Zhao}, doi = {10.1002/advs.202503095}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03095}, shortjournal = {Adv. Sci.}, title = {Mitochondrial regulation of CD8⁺ t cells: Mechanisms and therapeutic modulation}, volume = {12}, year = {2025}, }
• (2025). Mechanical metamaterial-based structure with magnetically controlled nonreversibility and nonreciprocity for programmable locomotion. ADVS, 12(32), e03088. (www)

  @article{ , abstract = {Programmable mechanical metamaterials hold the key to critical innovations in materials science research, by harnessing relatively unexplored nonlinearities that change effective responses. Effective properties of a metamaterial strongly depend on the reversibility of the deformation process. While most elastic materials show reciprocity and reversibility, the possibility of concurrently observing nonreciprocity, defined as a deformation that is not mirrored when a body is loaded equally from opposite sides, as well as a nonreversible deformation process, opens doors to addressing complex mechanical problems that are crucial from the perspective of soft body dynamics. In this work, a magneto-mechanical metamaterial-based structure is proposed that simultaneously exhibits both of these phenomena by utilizing elastic and magnetically induced nonlinearities. It is shown that such a system can undergo a transition in its static mechanical properties, such as Poisson's ratio and stiffness, leading to stark changes in energy absorption. It is also demonstrated that, thanks to the asymmetric distribution of magnetic inclusions, the entire structure can exhibit an efficient locomotion mechanism suitable for applications in robotics.}, archive = {J_ADVS}, author = {Krzysztof K. Dudek and Olly Duncan and Julio A. Iglesias Martínez and Muamer Kadic}, doi = {10.1002/advs.202503088}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03088}, shortjournal = {Adv. Sci.}, title = {Mechanical metamaterial-based structure with magnetically controlled nonreversibility and nonreciprocity for programmable locomotion}, volume = {12}, year = {2025}, }
• (2025). Identification of schwann cells in human intracranial arteries: Potential regulatory role in atherosclerotic plaque progression. ADVS, 12(32), e03033. (www)

  @article{ , abstract = {Intracranial atherosclerosis (ICAS), a common cause of ischemic stroke, remains a therapeutic challenge due to complex intracranial anatomy and intervention risks. Although ICAS develops intracranially, cerebral artery innervation originates in the peripheral nervous system. The scarcity of human intracranial specimens has hindered investigations into the potential role of Schwann cells (SCs) in neurovascular homeostasis. Using multimodal analysis of plaque-bearing and non-plaque-bearing intracranial artery samples from the same postmortem individuals (n = 16 donors), SCs associated with myelinated neural structures are identified. Quantitative ultrastructural evaluation reveals a 4.3-fold increase in SC-derived myelin sheaths within plaque-bearing vessels ( P <0.001). Single-cell RNA sequencing (scRNA-seq) of SCs demonstrates significant upregulation of genes involved in axonogenesis, axon ensheathment, axon guidance, synaptic transmission, and synaptic integration. Cell–cell communication analysis shows enhanced interactions between SCs and vascular smooth muscle cells (VSMCs) in plaque-bearing vessels. Synaptic-like structures are observed in the walls of intracranial arteries, along with a 2.9-fold increase in VSMC-innervating myelinated fibers ( P <0.001). Ligand–receptor analysis indicates SPP1–ITGB1 signaling as a potential mediator of SCs-VSMCs crosstalk. This study provides evidence for the involvement of SCs in ICAS pathobiology and proposes novel neurovascular targets for precision therapies in cerebrovascular disease.}, archive = {J_ADVS}, author = {Zijue Wang and Yangzhige He and Weizhuang Yuan and Yijun Xia and Manqiu Ding and Zhen Chen and Naili Wang and Chao Ma and Xiaoyue Wang and Yan Xu and Weihai Xu}, doi = {10.1002/advs.202503033}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e03033}, shortjournal = {Adv. Sci.}, title = {Identification of schwann cells in human intracranial arteries: Potential regulatory role in atherosclerotic plaque progression}, volume = {12}, year = {2025}, }
• (2025). Mn3SnN-based antiferromagnetic tunnel junction with giant tunneling magnetoresistance and multi-states: Design and theoretical validation. ADVS, 12(32), e02985. (www)

  @article{ , abstract = {Antiferromagnets have attracted widespread interest due to the advantages of no stray fields and ultrafast switching dynamics, promising for next-generation high-speed, high-density memories. However, over a long period, the effective detection of antiferromagnetic (AFM) orders remained being one of the greatest challenges of its application in magnetic random access memories (MRAM) because of its zero net magnetization. Recently, the preliminary demonstration of the tunneling magnetoresistance ratio(TMR) in antiferromagnetic tunnel junctions (AFMTJ) offered a feasible solution. Here, a Mn 3 SnN/SrTiO 3 /Mn 3 SnN non-collinear AFMTJ is designed and its transport properties are predicted by ab initio quantum transport simulations. Due to the momentum matching between the spin-polarized Fermi surface of the Mn 3 SnN electrode and the low-decay-rate evanescent states of the SrTiO 3 barrier, a remarkable TMR ≈1500% is generated, corresponding to a large device read margin, resulting in higher storage density. In addition, changing the relative orientation of two Mn 3 SnN magnetic orders leads to four non-volatile resistance states with a low resistance area (RA) of only 0.07–1.25 Ω•µm 2 and three multi-state TMR of ≈500, 1000, and 1500%, suitable for high-energy-efficiency multiple-state memory application. Our work provides a promising device structure for future nonvolatile high-speed, high-density, and multiple-state AFM memories.}, archive = {J_ADVS}, author = {Shiqi Liu and Tingwei Chen and Baochun Wu and Haodong Fan and Yingmei Zhu and Sheng Bi and Yuntian Liu and Yinuo Shi and Wenbiao Zhang and Mengxi Wang and Qiang Li and Jie Yang and Jing Lu and Tiejun Zhou and Bo Liu}, doi = {10.1002/advs.202502985}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02985}, shortjournal = {Adv. Sci.}, title = {Mn3SnN-based antiferromagnetic tunnel junction with giant tunneling magnetoresistance and multi-states: Design and theoretical validation}, volume = {12}, year = {2025}, }
• (2025). Bio-inspired strategy for radiation-based thermal management and utilization. ADVS, 12(32), e02851. (www)

  @article{ , abstract = {In nature, biological species have evolved unique mechanisms and sophisticated structures for intelligent radiation-based thermal management and utilization over billions of years through natural selection. These adaptive strategies in biological species serve as a significant source of inspiration for the development of advanced thermal engineering materials and systems in modern society, driving innovation in applications such as building heating and cooling, personal thermal management, water acquisition, and next-generation infrared (IR) sensing systems. In this review, advancements in biological and bio-inspired thermal management strategies, including radiative cooling, thermal regulation, and thermal insulation, are comprehensively summarized. Additionally, recent advancements in radiation-based biological and bio-inspired thermal utilization are discussed, focusing on applications such as water harvesting, IR camouflage, and IR detection. Next, various examples of the integration of IR management strategies with electronic and energy systems are introduced, highlighting their potential to enhance efficiency and functionality in thermal management, energy efficiency, and advanced sensing applications. By leveraging these bio-inspired systems, innovative strategies have emerged, encompassing both thermal management and utilization, and enabling efficient heat regulation and energy harvesting across a wide range of technological applications. Finally, a future perspective on the development of radiation-based bio-inspired thermal management and utilization technologies is provided.}, archive = {J_ADVS}, author = {Hyung Rae Kim and Won Bae Han and Se-Yeon Heo and Yun Su Go and Suk-Won Hwang and Young Min Song}, doi = {10.1002/advs.202502851}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02851}, shortjournal = {Adv. Sci.}, title = {Bio-inspired strategy for radiation-based thermal management and utilization}, volume = {12}, year = {2025}, }
• (2025). Single-cell RNA sequencing identifies MMP11+ cancer-associated fibroblasts as drivers of angiogenesis and bladder cancer progression. ADVS, 12(32), e02774. (www)

  @article{ , abstract = {Cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression, with heterogeneity influencing therapeutic response and prognosis, highlighting their potential as viable targets for treatment. In this study, a novel CAF subgroup, MMP11 + mCAF is identified, through single-cell RNA sequencing, which accumulates progressively during bladder cancer progression and is significantly associated with poor prognosis. This cell population regulates the migration of tip endothelial cell clusters (ESM1 + tEC) via the WNT5A-MCAM signaling axis, and modulates the expression of key transcription factors, SOX18 , NFIC , and HOXB9 . Additionally, MMP11 + mCAFs recruit SPP1 + macrophages through CCL11/CCL2, promoting VEGFA secretion, which further enhances the pro-angiogenic activity of ESM1 + tECs. Furthermore, interferon-associated basal-like tumor cells secrete BMP2, which induces the expression and activity of NFE2L3, a transcription factor specific to MMP11 + mCAFs, promoting WNT5A expression. Mouse experiments confirmed that inhibiting BMP2 can suppress tumor angiogenesis and growth in bladder cancer. Pan-cancer analysis revealed that MMP11 + mCAFs are present across various cancer types, including breast cancer, lung adenocarcinoma, gastric cancer, and colorectal cancer. These findings provide insights into the heterogeneity of CAFs and their regulatory role in tumor progression, offering new potential therapeutic targets for CAF-targeted treatments with broad applicability across cancers.}, archive = {J_ADVS}, author = {Wuwu Xu and Ting Liang and Hu Fang and Lu Fu and Dashi Deng and Xiyang Tan and Lisha Liu and Dongdong Tang and Haoxiang Zheng and Qiuxia Ding and Xiuqi Hou and Daquan Feng and Tao Tao and Song Wu}, doi = {10.1002/advs.202502774}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02774}, shortjournal = {Adv. Sci.}, title = {Single-cell RNA sequencing identifies MMP11+ cancer-associated fibroblasts as drivers of angiogenesis and bladder cancer progression}, volume = {12}, year = {2025}, }
• (2025). EBBP-mediated integrated stress response attenuates anthracycline-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes. ADVS, 12(32), e02726. (www)

  @article{ , abstract = {Anthracyclines are potent chemotherapeutics, but their clinical application is constrained by dose-dependent cardiotoxicity, in which ferroptosis plays a critical role. Here, EBBP (Estrogen-responsive B Box Protein) is identified as a key cardioprotective regulator in anthracycline-induced cardiotoxicity. Transcriptomic profiling of doxorubicin (DOX)-treated hearts reveals significant EBBP upregulation. Cardiac-specific overexpression of EBBP protects against myocardial injury and dysfunction by reducing DOX-induced ferroptosis. Conversely, EBBP silencing exacerbates DOX-induced cardiac damage, an effect reversed by ferroptosis inhibitor ferrostatin-1 (Fer-1). The molecular targets of EBBP are subsequently identified through bulk RNA sequencing, molecular docking analysis, co-immunoprecipitation experiments, and ubiquitination assays. Mechanistically, EBBP interacts with GRP78 to promote its K63-linked ubiquitination, disrupting the inhibitory GRP78-PERK interaction and activating PERK-mediated integrated stress response (ISR). This signaling cascade ultimately leads to the activation of downstream effectors ATF4 and Nrf2, which coordinately upregulates the SLC7A11/GSH/GPX4 axis and restores iron homeostasis. Importantly, pharmacological inhibition of PERK abolishes the protective effects of EBBP against myocardial injury and ferroptosis. Overall, our findings identify EBBP as a novel suppressor of ferroptosis in anthracycline-induced cardiotoxicity via the PERK-mediated ISR, thereby underscoring its therapeutic potential for preventing anthracycline-induced cardiomyopathy.}, archive = {J_ADVS}, author = {Zilong Chen and Can Chen and Yichen Wu and Yinxue Xia and Ruijie Luo and Jiangcheng Shu and Long Chen and Zhaohui Wang and Cheng Wang and Kai Huang}, doi = {10.1002/advs.202502726}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02726}, shortjournal = {Adv. Sci.}, title = {EBBP-mediated integrated stress response attenuates anthracycline-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes}, volume = {12}, year = {2025}, }
• (2025). Fully automated deep learning enabled miniature mass spectrometry system for psychoactive therapeutic drug monitoring. ADVS, 12(32), e02721. (www)

  @article{ , abstract = {Advancing precision medicine requires efficient small molecule biomarker detection in biofluids, yet existing methods encounter challenges in complexity, portability, and throughput. This study presents an integrated miniature blood processing and mass spectrometry (MS) analysis system, which incorporates automated magnetic solid-phase extraction, self-aspiration sampling miniature mass spectrometer, and deep learning algorithms for automated quantitative analysis. It achieves full automation from sample preparation to detection, demonstrating the capability to analyze serum psychoactive drugs with a 15-second/MS acquisition and 8-sample parallel processing within 30 minutes (including pretreatment). This has significantly increased detection throughput and facilitated the establishment of the standard curve. The novel dual-target ion parallel tandem MS analysis technique, combined with a U-net peak area recognition algorithm, achieved over 98% identification accuracy with less than 0.2% area prediction deviation. Quantitative analysis showed high correlation coefficients >0.99 in medically relevant ranges, supported by relative standard deviation < 10% and average back-calculated accuracy deviation < 3.5%. Clinical validation revealed strong concordance with LC-MS/MS. The system's integration of automated sample processing, miniature MS hardware, and AI-driven data analysis establishes a paradigm for high-throughput clinical detection. The advantages of accuracy, automation, intelligence, miniaturization, and high throughput suggest significant potential for this system in clinical detection and personalized medicine.}, archive = {J_ADVS}, author = {Yuanhao Zhou and Jiawen Ai and Zi Ye and Kexin Chen and JingXiong Lin and Zhenhua Zhang and Mi Luo and Benjie Zhou and Shijian Xiang and Jianhua Zhou and Xinming Huo}, doi = {10.1002/advs.202502721}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02721}, shortjournal = {Adv. Sci.}, title = {Fully automated deep learning enabled miniature mass spectrometry system for psychoactive therapeutic drug monitoring}, volume = {12}, year = {2025}, }
• (2025). Genomic variation underpins genetic divergence and differing salt resilience in sesbania bispinosa. ADVS, 12(32), e02600. (www)

  @article{ , abstract = {Halophytes possess inherent stress resilience and diverse adaptations, making them valuable genetic reservoirs for crop breeding. The leguminous halophyte Sesbania bispinosa is a valuable forage crop that thrives in saline soils. To explore its salt tolerance, high-quality genome assemblies is generated for the salt-tolerant S. bispinosa accession SbTA02 and the salt-sensitive accession SbSA44. Genomic analysis revealed that the genomic divergence between the two accessions primarily originates from their pericentromeric and centromeric regions, which contain the two largest inversions: a >27-Mb inversion on chromosome 5 and a ≈49-Mb inversion on chromosome 6. Population-level analysis revealed that the 27-Mb inversion is widespread in S. bispinosa , dividing the tested populations into inland and coastal groups. These groups have many genetic divergence regions (GDRs), with genetically isolated haplotypes in the middle section of chromosome 5, including the large inversion and centromeric regions. Genome-wide association studies (GWAS) identified significant salt-tolerance signals in the GDRs, pinpointing the anthocyanidin synthase gene SbANS . Natural variation in SbANS is associated with differences in salt tolerance between salt-tolerant and salt-sensitive S. bispinosa accessions. These findings provide insights into the genomic evolution of the Sesbania genus and shed light on how genomic variation shapes genome architecture, genetic divergence, and phenotypic differentiation.}, archive = {J_ADVS}, author = {Gai Huang and Xiaofei Wang and Chengli Liu and Kaixuan He and Xiu-Li Hou and Haofei Luo and Shuaibin Zhang and Changqing You and Yajun Jia and Fuqiang Wang and Xianwei Song and Guodao Liu and Xian Deng and Xiaofeng Cao}, doi = {10.1002/advs.202502600}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02600}, shortjournal = {Adv. Sci.}, title = {Genomic variation underpins genetic divergence and differing salt resilience in sesbania bispinosa}, volume = {12}, year = {2025}, }
• (2025). Combining PIM-2 and PARP1 inhibitors induces MICA expression on multiple myeloma cells to activate NK cells through NKG2D binding. ADVS, 12(32), e02448. (www)

  @article{ , abstract = {While immunogenic death in tumor cells activates specific anti-tumor T cells, the activation of non-specific natural killer (NK) cells through tumor interactions remains underexplored. This study investigates how inducing DNA damage in multiple myeloma (MM) cells leads to MICA overexpression, facilitating NKG2D binding on NK cells.We analyzed the relationship between PIM-2, PARP1, and MM prognosis using public data and clinical samples. An in vitro co-culture of MM and NK cells assessed the effects of SMI-16a (PIM-2 inhibitor) and ABT888 (PARP1 inhibitor) on tumor proliferation and apoptosis, focusing on DNA damage, MICA expression, and NK cell functionality. An NSG mouse model evaluated the combined effects on tumor growth and NK cell activity.The combination significantly increased DNA damage, marked by elevated pH2AX, and enhanced NK cell functional markers, including perforin and granzyme B. Increased DNA damage correlated with heightened MICA expression, activating NK cells via the NKG2D/MICA signaling pathway. PIM-2 and PARP1 inhibitors synergistically induce MICA expression on MM cells, enhancing NK cell activation through NKG2D binding, offering a promising therapeutic strategy for MM patients.}, archive = {J_ADVS}, author = {Zhaoyun Liu and Wenhui Lei and Xiaohan Liu and Hui Liu and Kai Ding and Jia Song and Rong Fu}, doi = {10.1002/advs.202502448}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02448}, shortjournal = {Adv. Sci.}, title = {Combining PIM-2 and PARP1 inhibitors induces MICA expression on multiple myeloma cells to activate NK cells through NKG2D binding}, volume = {12}, year = {2025}, }
• (2025). Primer-disk-enabled DNA data storage system with index and record-many-read-many features. ADVS, 12(32), e02367. (www)

  @article{ , abstract = {DNA data storage has emerged as a promising information storage technology by encoding information down to base molecules. However, it remains a challenge to structure the DNA data with ease of recording, retrieving, and reading. Here, a primer-disk-enabled hierarchical DNA data storage system is introduced, which allows for the multiple immobilizations of DNA molecules and the generation of corresponding QR codes for retrieving. The primer disk is pre-engineered to present multiple primers, on which encoded DNA molecules with complementary primers can be covalently immobilized on demand via solid-phase PCR. Each DNA file can be retrieved by inkjet printing a fluorescent QR code. A primer disk with up to 10 primers is used. The results show that different DNA files can be subsequently stored on the disk. One can have readily access to the index via fluorescent QR codes and decode information after sequent imaging, convention, and recognition. To this end, the recorded DNA files can be randomly read via solid-phase PCR with sufficient copies of collected DNA for up to 20 reads. Together, this work provides a new DNA data storage system with index and record-many-read-many features, paving the way for the practical use of DNA data storage.}, archive = {J_ADVS}, author = {Jiaxiang Ma and Yu Yang and Ben Pei and Shengli Mi and Zhuo Xiong and Liliang Ouyang}, doi = {10.1002/advs.202502367}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02367}, shortjournal = {Adv. Sci.}, title = {Primer-disk-enabled DNA data storage system with index and record-many-read-many features}, volume = {12}, year = {2025}, }
• (2025). Operando characterization of uranium dendrite growth in high-temperature molten salt electrochemistry by synchrotron X-ray tomography and diffraction. ADVS, 12(32), e02345. (www)

  @article{ , abstract = {In this study, an innovative operando characterization methodology utilizing synchrotron radiation X-ray micro-computed tomography (SR-µCT) and high-energy X-ray diffraction (HEXRD) to investigate dendritic electrodeposition in high-temperature molten salt (HTMS) electrochemistry is presented. This approach enables the in-situ visualization and quantification of uranium dendrite growth and ion diffusion dynamics during the electrochemical reaction of LiCl-KCl-UCl 3 molten salt. Through 3D reconstruction of uranium dendrite imaging and multiphysics simulations of the uranium electrolysis process, the underlying mechanisms of uranium dendrite formation are elucidated. Additionally, in situ HEXRD analysis of electrodeposited uranium reveals that the dendritic growth morphology is intrinsically linked to its crystal structure and orientation. This research not only advances the understanding of uranium dendrite growth and evolution but also establishes a foundational framework for the development of effective dendrite suppression strategies. These findings contribute significantly to the field of HTMS electrochemistry and have potential implications for the design of advanced electrochemical systems.}, archive = {J_ADVS}, author = {Kui Liu and Tan Tan and Yuke Zhong and Yafei Wang and Tao Bo and Zimei Bai and Shanfeng Wang and Kai Zhang and Wanxia Huang and Jianrong Zeng and Weiqun Shi}, doi = {10.1002/advs.202502345}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e02345}, shortjournal = {Adv. Sci.}, title = {Operando characterization of uranium dendrite growth in high-temperature molten salt electrochemistry by synchrotron X-ray tomography and diffraction}, volume = {12}, year = {2025}, }
• (2025). Abiotic factors and plant communities shape the distribution of soil pathogenic oomycetes in chinese grasslands. ADVS, 12(32), e01994. (www)

  @article{ , abstract = {The outbreaks of emerging phytopathogens constrain socioeconomic development globally and are expected to intensify in the future along with climate change. Oomycetes, a group of fungus-like eukaryotes, include many phytopathogenic species, making it critical to understand the drivers of their diversity and distribution. This work analyzes 972 soil samples from three major grassland types in China and found that soil phosphorus availability drove oomycete richness, while humidity and nitrogen content affected community composition. Pathogenic oomycete abundance is mostly influenced by precipitation, temperature seasonality, and plant species richness. This work creates a distribution atlas of pathogenic oomycete richness and abundance in Chinese grasslands, using space-for-time methods to predict future outbreak areas under climate change. Model predictions indicate a potential increased risk of oomycete disease in ≈42% of the grassland area under SSP 1–2.6 and SSP 5–8.5 climate scenarios, particularly in portions of typical and meadow grasslands. This study enhances the understanding of the drivers behind the distribution of pathogenic oomycetes and highlights the need for disease management strategies in the face of climate change.}, archive = {J_ADVS}, author = {Junsheng Ke and Chen Zhu and Peixi Jiang and Peng Zhang and Kui Hu and Yilin Dang and Yao Xiao and Mu Liu and Huiying Liu and Xiang Liu and Ville-Petri Friman}, doi = {10.1002/advs.202501994}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01994}, shortjournal = {Adv. Sci.}, title = {Abiotic factors and plant communities shape the distribution of soil pathogenic oomycetes in chinese grasslands}, volume = {12}, year = {2025}, }
• (2025). Nanomedicine-driven modulation of reductive stress for cancer therapy. ADVS, 12(32), e01968. (www)

  @article{ , abstract = {Redox balance is crucial for cellular function and adaptation to environmental changes, with its disruption playing a key role in the progression of various diseases, including cancer. While oxidative stress caused by excessive reactive oxygen species (ROS) has been widely studied and targeted in cancer therapies, such approaches face significant challenges within the tumor microenvironment. On the opposite end, reductive stress results from an overabundance of reducing equivalents, disrupting normal ROS-dependent signaling pathways and leading to cellular dysfunction. Despite its importance in tumor biology, reductive stress has received less attention than oxidative stress. This group has deliberately driven tumors into a state of reductive stress, thereby exposing unique vulnerabilities and validating a novel therapeutic strategy. Here, the concept and mechanisms of reductive stress is reviewed, introduced methods for detecting it, and discussed its dual role in tumor progression and potential as a therapeutic target. Recent advances in nanomedicine, particularly in the design of functional nanomaterials, enabling precise modulation of cellular redox states are also highlighted. By selectively inducing reductive stress within tumors, nanomedicine offers a promising strategy to exploit tumor vulnerabilities, overcome drug resistance, and improve cancer therapy efficacy.}, archive = {J_ADVS}, author = {Yumin Mao and Xianping Liu and Xu Chu and Feixiang Chen and Ruicheng Shi and Zonghao Liu and Yelin Wu and Yanyan Liu and Wenbo Bu}, doi = {10.1002/advs.202501968}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01968}, shortjournal = {Adv. Sci.}, title = {Nanomedicine-driven modulation of reductive stress for cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Nephronectin (NPNT) is a crucial determinant of idiopathic pulmonary fibrosis: Modulating cellular senescence via the ITGA3/YAP1 signaling axis. ADVS, 12(32), e01956. (www)

  @article{ , abstract = {Idiopathic pulmonary fibrosis (IPF) is a prototype of chronic, progressive, and fibrotic lung disease. While advancing age is recognized as the most significant risk factor for both the development and mortality associated with pulmonary fibrosis, precise mechanisms underlying this association remain elusive. Here, Nephronectin (NPNT) is identified as an antiaging molecule, a potential major regulator of the progression of pulmonary fibrosis. In IPF patients, a marked reduction in NPNT expression is detected in lung tissues, which correlated with a decline in lung function. The study reveals that NPNT deficiency exacerbates bleomycin-induced senescence in alveolar epithelial cells, potentially intensifying fibrosis severity due to diminishes extracellular matrix turnover. Conversely, NPNT overexpression in the alveolar epithelium improves lung respiratory function and enhances resistance to aging and fibrosis. Mechanistically, NPNT inhibits the hyperactivation of LATS1 and MOB1, facilitates YAP1 nuclear translocation, and suppresses YAP1 ubiquitination and degradation, contingent upon the interaction between NPNT and ITGA3. Notably, pharmacological elevation of NPNT protein levels using Escin has been shown to alleviate pulmonary fibrosis and improve lung function in mice. The findings shed light on the key mechanism underlying stress-induced senescence and fibrosis, and offer a promising framework for interventions targeting aging-related diseases.}, archive = {J_ADVS}, author = {Jiayu Guo and Yan Wang and Qiudi Liu and Zhaoyang Luo and Xiaomu Tian and Yuquan Wang and Yang Liu and Zhiwei Ning and Yingying Guo and Huiying Gao and Xinyue Wang and Jinglong Feng and Mengmeng Liu and Dina Saifullina and Yixin Zhang and Tengfei Pan and Yu Bian and Tao Ban and Tianyu Li and Yunyan Gu and Haihai Liang}, doi = {10.1002/advs.202501956}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01956}, shortjournal = {Adv. Sci.}, title = {Nephronectin (NPNT) is a crucial determinant of idiopathic pulmonary fibrosis: Modulating cellular senescence via the ITGA3/YAP1 signaling axis}, volume = {12}, year = {2025}, }
• (2025). MoS2 channel-enhanced high-density charge trap flash memory and machine learning-assisted sensing methodologies for memory-centric computing systems. ADVS, 12(32), e01926. (www)

  @article{ , abstract = {Driven by the shift of artificial intelligence (AI) workloads to edge devices, there is a growing demand for nonvolatile memory solutions that offer high-density, low-power consumption, and reliability. However, well-established 3D NAND Flash using polycrystalline Si (Poly-Si) channel encounters bottlenecks in increasing bit density due to short-channel effects and cell-current limitations. This study investigates molybdenum disulfide (MoS 2 ) as an alternative channel material for 3D NAND Flash cells. MoS 2 ’s low bandgap facilitates hole-injection-based erase, achieving a broader memory window at moderate voltages. Furthermore, adopting a low- k (≈2.2) tunneling layer improves the gate-coupling ratio, reducing program/erase voltages and enhancing reliability, with endurance up to 10 4 cycles and retention of 10 5 s. Comprehensive analyses, including thickness-dependent MoS 2 electrical measurements, temperature-dependent conduction studies, and Technology Computer-Aided Design (TCAD) simulations, elucidate the relationship between channel thickness and reliability metrics such as endurance and retention. Furthermore, deep reinforcement learning–driven Berkeley Short-channel IGFET Model (BSIM) parameter calibration enables seamless integration of the MoS 2 model with a fabricated page-buffer chip, allowing circuit-level verification of sensing margins. This methodology can be applicable to new channel materials for next-generation memory devices. These results demonstrate that MoS 2 -based nonvolatile memory effectively meets high-density, low-power, and reliable storage needs, presenting a promising solution for AI-centric edge computing.}, archive = {J_ADVS}, author = {Ki Han Kim and Ju Han Park and Khang June Lee and Ji-Won Seo and Yeong Kwon Kim and Junhwan Choi and Min-Jae Seo and Byung Chul Jang}, doi = {10.1002/advs.202501926}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01926}, shortjournal = {Adv. Sci.}, title = {MoS2 channel-enhanced high-density charge trap flash memory and machine learning-assisted sensing methodologies for memory-centric computing systems}, volume = {12}, year = {2025}, }
• (2025). Toward the clinical translation of implantable Brain–Computer interfaces for motor impairment: Research trends and outcome measures. ADVS, 12(32), e01912. (www)

  @article{ , abstract = {Implantable brain–computer interfaces (iBCIs) decode neural signals to control external effectors, offering potential to restore function in individuals with severe motor impairments, such as loss of limb function or speech. This systematic review examines the evolution of iBCI research and key bottlenecks to clinical translation, particularly the absence of standardized, clinically meaningful outcome measures. A comprehensive search of MEDLINE, Embase, and CINAHL identifies 112 studies, nearly half (49.1%) published since 2020. Eighty unique iBCI participants were identified, providing the most up-to-date estimate of global users. Research remains concentrated in the United States (83%), with growing contributions from Europe, China, and Australia. Electrocorticography (ECoG)-based devices increasingly emerge alongside micro-electrode arrays. iBCI devices are now being used to control a broader range of effectors, including robotic prosthetics and digital technologies. Although most (69.6%) studies reported outcome measures prospectively, these primarily related to decoding (69.6%) and task performance (62.5%), with only 17.9% assessing clinical outcomes. When cassessed, clinical outcomes were highly heterogeneous due to varied approaches across target populations. iBCIs show potential to restore functional independence at scale. However, challenges remain around cross-subject generalization, scalable implantation, and outcome standardization. Novel measures should be developed collaboratively with engineers, clinicians, and individuals with lived experience of motor impairment.}, archive = {J_ADVS}, author = {Esmee Dohle and Eleanor Swanson and Luka Jovanovic and Suraya Yusuf and Lucy Thompson and Hugo Layard Horsfall and William Muirhead and Luke Bashford and Jamie Brannigan}, doi = {10.1002/advs.202501912}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01912}, shortjournal = {Adv. Sci.}, title = {Toward the clinical translation of implantable Brain–Computer interfaces for motor impairment: Research trends and outcome measures}, volume = {12}, year = {2025}, }
• (2025). Surface rolling active magnetic emulsions. ADVS, 12(32), e01866. (www)

  @article{ , abstract = {Active emulsions can exhibit chemotactic locomotion in fuel-rich conditions like their biological counterparts. However, possessing extensive control over the spontaneous motion of chemotactic droplets and achieving their locomotion in fuel-deficient environments remains as a challenge. Here, synthetic rotational flows are incorporated to augment droplets with on-demand surface rolling ability. These rotational flows arise from a freely rotating magnetic cluster encapsulated within an oil droplet and aid in locomotion in fuel-deficient regions. Combining autonomous and synthetic flows aids in switchable locomotion modes enabling active magnetic droplets to explore confined spaces by avoiding concentration gradient traps and entering narrow spaces. Finally, on-demand switchability between surface rolling and autonomous swimming modes allows the active magnetic droplets to locomote against chemotactic gradients, while transporting and manipulating surrounding micro/nanoscale entities.}, archive = {J_ADVS}, author = {Muhammad Turab Ali Khan and Gaurav Gardi and Ugur Bozuyuk and Metin Sitti}, doi = {10.1002/advs.202501866}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01866}, shortjournal = {Adv. Sci.}, title = {Surface rolling active magnetic emulsions}, volume = {12}, year = {2025}, }
• (2025). Oxygen vacancy formation at Metal‒TiO₂ interface yielding enhanced photocatalytic hydrogen generation. ADVS, 12(32), e01835. (www)

  @article{ , abstract = {Strong Metal-Support Interaction (SMSI) is a key concept in heterogeneous catalysis, but it remains underexplored in the context of photon-to-hydrogen conversion, as coupling of metallic nanoparticles with photocatalysts is overlooked and only discussed in terms of Schottky barrier formation. In this study, we provide deep insights into the effect of Au encapsulation with TiO 2 overlayer on enhancing photocatalytic hydrogen generation. Our findings reveal that the construction of a SMSI-like nanostructure induces the formation of oxygen vacancies at the Au‒TiO 2 interface which actively facilitate charge carrier separation through interfacial band reconstruction. The presence of defects is evidenced by Electron Paramagnetic Resonance and X-ray Photoelectron Spectroscopy, unveiling their relationship with photocatalytic activities. Consistent with experimental results, Density Functional Theory (DFT) calculations demonstrate that Au promotes oxygen vacancy formation. These vacancies located at the TiO 2 surface significantly enhances H 2 O and MeOH adsorption during H 2 evolution reactions. The SMSI-like concept was extended to Pt, Pd, and Ag, in which the oxygen vacancy formation energy at the metal-semiconductor interface varied depending on the metal, as computed by DFT. The results suggest that photocatalytic activity is related to the ease of oxygen vacancy formation, which is influenced by the nature of the metals.}, archive = {J_ADVS}, author = {Vien-Duong Quach and Aparna Harsan and Maria Chiara Spadaro and Marc Botifoll and Jordi Arbiol and Marija Knezevic and Christophe Colbeau-Justin and Franck Dumeignil and Hervé Vezin and Robert Wojcieszak and Tangui Le Bahers and Carine Michel and Mohamed Nawfal Ghazzal}, doi = {10.1002/advs.202501835}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01835}, shortjournal = {Adv. Sci.}, title = {Oxygen vacancy formation at Metal‒TiO₂ interface yielding enhanced photocatalytic hydrogen generation}, volume = {12}, year = {2025}, }
• (2025). Emerging nanotechnology strategies for obesity therapy. ADVS, 12(32), e01813. (www)

  @article{ , abstract = {With the rising prevalence of obesity worldwide, the condition and its associated complications have become a significant public health challenge. The emergence of nanotechnology presents new opportunities for obesity treatment by enabling the design and manipulation of materials at the nanoscale to exhibit unique physicochemical properties, targeted delivery capabilities, and multifunctional therapeutic effects. This review systematically explores recent advances in nanotechnology-based strategies for obesity management, focusing on the pathological characteristics of obesity, the types of nanomaterials for the treatment, and the therapeutic strategies provided by nanotechnology. Furthermore, the review critically examines translational challenges while proposing innovative solutions. This work aims to foster the effective application and rapid advancement of nanotechnology in addressing obesity.}, archive = {J_ADVS}, author = {Weili Chang and Zhaoxu Meng and Yuezhu Zhao and Yake Qi and Zhou Li and He Lian}, doi = {10.1002/advs.202501813}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01813}, shortjournal = {Adv. Sci.}, title = {Emerging nanotechnology strategies for obesity therapy}, volume = {12}, year = {2025}, }
• (2025). Gompertz law-based biological age (GOLD BioAge): A simple and practical measurement of biological ageing to capture morbidity and mortality risks. ADVS, 12(32), e01765. (www)

  @article{ , abstract = {Biological age reflects actual ageing and overall health, but current ageing clocks are often complex and difficult to interpret, which limits their clinical application. This study introduces a Gompertz law-based biological age (GOLD BioAge) model designed to simplify the assessment of ageing. We calculated GOLD BioAge using clinical biomarkers and found significant associations between the difference from chronological age (BioAgeDiff) and the risks of morbidity and mortality in the NHANES and UK Biobank. Using proteomics and metabolomics data, we developed GOLD ProtAge and MetAge, which outperformed the clinical biomarker models in predicting mortality and chronic disease risk in UK Biobank. Benchmark analyses demonstrated that the models outperformed common ageing clocks in predicting mortality across diverse age groups in both the NHANES and UK Biobank cohorts. Additionally, a simplified version called Light BioAge is created, which uses three biomarkers to assess ageing. The Light model reliably captured the mortality risk across three validation cohorts (CHARLS, RuLAS, and CLHLS). It significantly predicted the onset of frailty, stratified frail individuals, and collectively identified individuals at high risk of mortality. In summary, the GOLD BioAge algorithm provides a valuable framework for the assessment of ageing in public health and clinical practice.}, archive = {J_ADVS}, author = {Meng Hao and Hui Zhang and Jingyi Wu and Yaqi Huang and Xiangnan Li and Meijia Wang and Shuming Wang and Jiaofeng Wang and Jie Chen and Zhi jun Bao and Li Jin and Xiaofeng Wang and Zixin Hu and Shuai Jiang and Yi Li}, doi = {10.1002/advs.202501765}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01765}, shortjournal = {Adv. Sci.}, title = {Gompertz law-based biological age (GOLD BioAge): A simple and practical measurement of biological ageing to capture morbidity and mortality risks}, volume = {12}, year = {2025}, }
• (2025). Iron oxide nanoparticles modified with galloylated DNA for magnetically enhanced DNA-directed assembly. ADVS, 12(32), e01491. (www)

  @article{ , abstract = {A straightforward, one-step method is presented for DNA functionalization of iron oxide nanoparticles (IONP) using galloylated DNA through multidentate metal-phenol interactions. The DNA-modified IONPs exhibit excellent stability under diverse buffer conditions and display intriguing DNA binding properties, influenced by the superparamagnetic property of IONPs. The DNA denaturation behavior can be categorized into two regimes: the magnetic-dominant regime and the DNA-dominant regime. In the magnetic regime, where IONPs are assembled using relatively short DNA linkers, magnetic and DNA interactions jointly stabilize the assemblies, resulting in an unusually weak length dependence of DNA melting temperature. As the linker length increases, the system transitions into the DNA-dominant regime, where the magnetic effect diminishes, and the assemblies exhibit conventional DNA length-dependence. This study offers a simple and robust approach for DNA functionalization of IONPs, which can be extended to other metal compound nanoparticles, and highlights the potential of utilizing magnetic reinforcement to modulate DNA-based nanoparticle assembly.}, archive = {J_ADVS}, author = {Murali Golla and Hyunjin Jeon and Shine K. Albert and Hojun Lee and Seulki Kang and Moon Jeong Park and So-Jung Park}, doi = {10.1002/advs.202501491}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01491}, shortjournal = {Adv. Sci.}, title = {Iron oxide nanoparticles modified with galloylated DNA for magnetically enhanced DNA-directed assembly}, volume = {12}, year = {2025}, }
• (2025). Microsphere strategy to generate conformal bone organoid units with osteoimmunomodulation and sustainable oxygen supply for bone regeneration. ADVS, 12(32), e01437. (www)

  @article{ , abstract = {Repairing large bone defects remains a major challenge, as current strategies—including autografts, allografts, and tissue-engineered scaffolds—are limited by donor shortage, suboptimal biocompatibility, and insufficient control of the regenerative microenvironment. Bone organoids offer a promising strategy by simulating bone tissue functions and microenvironments in vitro, showing great potential for bone repair. However, current bone organoids still face issues such as insufficient oxygen supply, and limited immune modulation, reducing their effectiveness for complex bone defect repair, especially when precise shape conformity is required. To address these challenges, bone organoid unit based on silk hydrogel microspheres is developed, introducing oxygen-releasing components and immune cells to better mimic the bone repair environment and enable conformal filling of irregular defects. In vitro, the system formed bone organoid units through 28 days culture that sustained cell viability, promoted M2 macrophage polarization, and enhanced osteogenesis and angiogenesis. In a critical-sized mouse cranial defect model, this strategy outperformed traditional approaches, showing superior bone regeneration and tissue integration. These findings indicate that the strategy effectively addresses key obstacles in bone repair, such as oxygen supply, immune modulation, and shape conformity, providing a promising solution for personalized bone regeneration.}, archive = {J_ADVS}, author = {Anfu Deng and Hao Zhang and Yan Hu and Jilong Li and Jian Wang and Xiao Chen and Zhen Geng and Ke Xu and Yuxiao Lai and Jianhua Wang and Yingying Jing and Long Bai and Jiacan Su}, doi = {10.1002/advs.202501437}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01437}, shortjournal = {Adv. Sci.}, title = {Microsphere strategy to generate conformal bone organoid units with osteoimmunomodulation and sustainable oxygen supply for bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Piezo1 activation improves NSCLC liver metastasis immunotherapy by overriding matrix stiffness-mediated bimodal PD-L1/CXCL10 regulation. ADVS, 12(32), e01335. (www)

  @article{ , abstract = {Immunotherapy efficacy in NSCLC is significantly reduced upon liver metastasis due to profound alterations in the tumor microenvironment, characterized by the absence of cyclic mechanical stretch and increased extracellular matrix (ECM) stiffness. However, the mechanisms underlying the synergistic regulation of these two mechanical cues on the immunotherapy response in NSCLC cells remain poorly understood. In this study, it is demonstrated that both mechanical and biochemical activation of the mechanosensitive ion channel Piezo 1 induces nuclear translocation of YAP, thereby promoting an immunotherapy-responsive tumor immune microenvironment (TIME) through enhanced expression of PD-L1 and secretion of chemokine C-X-C ligand 10 (CXCL10, chemokine recruiting CD8 + T cells) in NSCLC cells. The mathematical modeling further reveals that cyclic stretch modulates the PD-L1/CXCL10 response to ECM stiffness, shifting from a bimodal to a unimodal distribution. In a murine model of liver metastasis, the combination of Piezo 1 agonist with anti-PD-1 therapy significantly improves the immunotherapy response, as evidenced by elevated PD-L1 levels and increased CD8 + T cell infiltration. These findings underscore the critical role of Piezo 1 in enhancing the immunotherapeutic response in NSCLC liver metastasis and highlight its potential as a therapeutic target.}, archive = {J_ADVS}, author = {Tian Zhang and Yuan Li and Bo Cheng and Zhao Xu and Mengjie Liu and Jinteng Feng and Yixue Bai and Yang Yu and Panpan Jiang and Luying Geng and Feng Xu and Hui Guo}, doi = {10.1002/advs.202501335}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01335}, shortjournal = {Adv. Sci.}, title = {Piezo1 activation improves NSCLC liver metastasis immunotherapy by overriding matrix stiffness-mediated bimodal PD-L1/CXCL10 regulation}, volume = {12}, year = {2025}, }
• (2025). Weight cycling deregulates eating behavior in mice via the induction of durable gut dysbiosis. ADVS, 12(32), e01214. (www)

  @article{ , abstract = {Background & Aims: Alternating periods of excessive and restrained eating results in weight cycling (‘yo-yo’ effect), a suspected risk factor for eating behavior dysregulation such as binge eating. The hypothesis that recurrent diet alternation alters hedonic feeding regulation by changing either or both intestinal microbiota and brain neuronal and glial regulation in mouse is tested. Methods : C57BL/6 mice undergo 3 cycles of 1 week of western diet (WD) separated by 2 weeks of chow diet (CYCL group) or remain under chow diet (CTRL group). Results : CYCL mice exhibit weight cycling, with enhanced weight gain upon each WD feeding phase and increased energy intake specifically during the first hours following WD re-introduction, reminiscent of binge-eating episodes. Expression of reward-related genes in the striatum and thickness of the astro-glial barrier in the brain stem is enhanced in CYCL mice. Diet alternation induces caecal dysbiosis in CYCL mice. Gut microbiota transfer from CYCL mice to naive recipient mice recapitulates the altered eating behavior upon WD exposure. Conclusions : Alternation between high-energy and standard diets is established to durably remodel the gut microbiota and the brain toward a profile associated with an increase in hedonic appetite and that this microbiota signature affects hedonic feeding regulation.}, archive = {J_ADVS}, author = {Mélanie Fouesnard and Adélie Salin and Sandy Ribes and Magali Monnoye and Gaëlle Champeil-Potokar and Marie-Sabelle Hjeij and Gwénaëlle Randuineau and Léa Le Gleau and Selma Ben Fradj and Catherine Philippe and Alexandre Benani and Isabelle Denis and Véronique Douard and Gaëlle Boudry}, doi = {10.1002/advs.202501214}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01214}, shortjournal = {Adv. Sci.}, title = {Weight cycling deregulates eating behavior in mice via the induction of durable gut dysbiosis}, volume = {12}, year = {2025}, }
• (2025). Releasing 8.0 wt.% h2 from the LiBH4−2LiNH2 composite within 5 min under light illumination. ADVS, 12(32), e01140. (www)

  @article{ , abstract = {The absence of safe and efficient hydrogen storage technologies is the major bottleneck for widespread applications of hydrogen energy. Reactive hydride composites with high gravimetric and volumetric hydrogen densities are ideal hydrogen storage materials. However, their traditional dehydrogenation processes normally involving electric-thermal-chemical energy conversion require high operating temperatures and substantial energy inputs to heat the reactor and oven. In this study, using LiBH 4 −2LiNH 2 as a model system, that rapid dehydrogenation via a photo-thermal-chemical and/or photo-chemical energy conversion initiated by direct light irradiation is demonstrated and can be fulfilled in the presence of a catalyst and a photothermal agent. The experimental results revealed that the non-thermal effect of UV light plays a critical role in reducing the desorption temperature and enhancing the dehydrogenation kinetics. The collective photothermal and non-thermal effects drove over 8.0 wt.% hydrogen desorption from LiBH 4 −2LiNH 2 within 5 min, which is ≈60 times faster than the thermal dehydrogenation process at the same temperature.}, archive = {J_ADVS}, author = {Haoyang Yu and Zibo Cheng and Hong Wen and Han Wang and Qijun Pei and Yeqin Guan and Hujun Cao and Ping Chen}, doi = {10.1002/advs.202501140}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01140}, shortjournal = {Adv. Sci.}, title = {Releasing 8.0 wt.% h2 from the LiBH4−2LiNH2 composite within 5 min under light illumination}, volume = {12}, year = {2025}, }
• (2025). Dual-biomimetic bone adhesive with osteoimmunomodulatory capabilities for anatomical reconstruction of comminuted fractures. ADVS, 12(32), e01108. (www)

  @article{ , abstract = {The development of bone adhesives capable of restoring natural bone structure and function represents a pioneering advancement in surgical technology, offering significant potential to improve the treatment outcomes of comminuted fractures. However, the development of a clinically demand-driven adhesive, ensuring both reliable adhesion and osteogenic activity, poses a significant challenge. Herein, a structurally and functionally dual-biomimetic bone adhesive is developed through the design of an organic–inorganic network-enhanced hydrogel, which integrates caffeic acid-grafted collagen (CAC), aminated laponite (ALAP), and N-hydroxysuccinimide ester-terminated polyethylene glycol (tetra-PEG-SC). Benefiting from nanosheet-induced strengthening, the mechanically reinforced adhesive can maintain integrity under extreme compression (98%) and tensile (600%) deformations, facilitating anatomical repositioning of rabbit radius and porcine femur fractures. Of greater importance, the adhesive accelerated fracture healing, potentially via ROS scavenging and immunomodulation, as evidenced by reduced oxidative stress and M2 macrophage polarization in vitro. Assessed through an innovative rabbit radius comminuted fracture model, the injectable bone adhesive demonstrates rapid and flexible adhesion of bone fragments in a blood-rich environment, as observed over the 2 fold improvement in biomechanical and radiological performance compared with commercially available cyanoacrylate adhesives. This intricately designed bone adhesive holds promise as a novel solution for addressing complex fracture cases in surgical treatment.}, archive = {J_ADVS}, author = {Junyao Cheng and Hufei Wang and Ming Li and Jianpeng Gao and Xiao Liu and Chuyue Zhang and Pengfei Chi and Bo Li and Yuan Xve and Daoyang Fan and Zheng Wang and Jianheng Liu and Xing Wang and Licheng Zhang}, doi = {10.1002/advs.202501108}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01108}, shortjournal = {Adv. Sci.}, title = {Dual-biomimetic bone adhesive with osteoimmunomodulatory capabilities for anatomical reconstruction of comminuted fractures}, volume = {12}, year = {2025}, }
• (2025). Kindlin regulates mechanosensitive activation and adhesion assembly of integrin beta6. ADVS, 12(32), e01078. (www)

  @article{ , abstract = {Inside-out and outside-in activations of integrin both play important roles in adhesion formation and cell motility. While such mechanisms of RGD-binding integrin, including integrin β1 and β3, are well documented, mechanosensitive regulations of integrin β6 remain largely unknown. Using traction force-free RGD-membrane as the model system, integrin β6 and viscous RGD ligands initially colocalize, assemble micrometer-sized clusters (15-min), and then gradually dissipate (60-min). Domain-swapping approaches are used and find that integrin β6 chimera with integrin β1's cytoplasmic tail can establish the persistent spatial clustering, suggesting the involvement of inside-out signaling. In vitro, pulldown and microscale thermophoresis experiments reveal that cytoplasmic adapter kindlin2 is the key factor and specifically exhibits weak association with integrin β6. Such kindlin2 deficiency can in turn be restored by additional kindlin2 or the introduction of PIPK1 that promotes kindlin2 recruitment to the plasma membrane. Dissipated integrin β6 is found in non-active conformation. Strengthening the interaction between kindlin2 and integrin β6 stabilizes integrin β6 in active conformation and is necessary to promote the migration of AsPC-1 cells on the soft PDMS. Thus, kindlin-mediated inside-out activation of integrin β6 bypasses extracellular force-dependent signaling and regulates the mechanosensitive adhesion assembly and cell migration on the compliant substrate.}, archive = {J_ADVS}, author = {Wan Ning Lee and Jiamin Li and Nan-Peng Chen and Cheng-han Yu}, doi = {10.1002/advs.202501078}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e01078}, shortjournal = {Adv. Sci.}, title = {Kindlin regulates mechanosensitive activation and adhesion assembly of integrin beta6}, volume = {12}, year = {2025}, }
• (2025). Paracrine orchestration of tumor microenvironment remodeling induced by GLO1 potentiates lymph node metastasis in breast cancer. ADVS, 12(32), e00722. (www)

  @article{ , abstract = {Breast cancer is the most prevalent form of malignant tumor that frequently metastasizes to axillary lymph nodes (LNs). Nonetheless, the precise mechanisms underlying alterations in the tumor microenvironment (TME) in LN metastasis in breast cancer remain poorly understood. Single-cell RNA sequencing of 28 LN samples from 23 patients is performed, and a comprehensive landscape of the entire ecosystem is generated. Ten major cell types are identified, with the subclusters of each major cell type exhibiting diverse characteristics. Furthermore, multiple signatures are collected to evaluate the key components of the subclusters using multi-omics methodologies. This study finds that myCAFs may hasten LN metastasis, and observed a notable increase in APOE + macrophages and a higher proportion of exhausted CD8 + T cells, contributing to the immunosuppressive TME. Moreover, cancer cells in metastatic lesions exhibited diverse expression patterns linked to proliferation, metastasis, oxidative phosphorylation, hypoxia, and interferon responses. Using multi-omics approaches and experimental validations, it determines that GLO1 can promote lymphatic angiogenesis, metastasis, and inhibit the proteasomal degradation of GSS , thereby maintaining intracellular glutathione (GSH) and reactive oxygen species (ROS) balance. Collectively, the study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting that GLO1 may be a promising therapeutic target.}, archive = {J_ADVS}, author = {Jindong Xie and Wenjian Liu and Xinpei Deng and Huan Wang and Xueqi Ou and Xin An and Min-Yi Situ and Anli Yang and Chuan Peng and Rongfang He and Yi Xie and Hailin Tang and Yuman Chen and Jie-Ying Liang and Ruonan Shao and Weikai Xiao and Shaoquan Zheng}, doi = {10.1002/advs.202500722}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e00722}, shortjournal = {Adv. Sci.}, title = {Paracrine orchestration of tumor microenvironment remodeling induced by GLO1 potentiates lymph node metastasis in breast cancer}, volume = {12}, year = {2025}, }
• (2025). Interference pattern caused by bilateral bone conduction stimulation impairs sound localization. ADVS, 12(32), e00302. (www)

  @article{ , abstract = {While bilateral fitting of bone conduction hearing devices (BCHDs) enhances spatial hearing, further improvements are constrained by the unresolved effects of crosstalk – an influential factor that disrupts binaural acoustic cues, such as interaural level difference (ILD) and interaural phase differences (IPD), essential for accurate sound localization. This paper introduces a simplified theoretical model to describe the crosstalk phenomenon and predict the cochlear vibrational responses under bilateral bone conduction (BC) based on principles of wave interference and superposition. The model reveals sound lateralization patterns across different ILD and IPD combinations, different from well-established principles governing air conduction (AC) sound localization, including the precedence effect and intensity rule. These predicted patterns are experimentally validated through cadaveric vibration measurements and are further corroborated in psychoacoustic sound lateralization tests conducted on healthy volunteers. The findings suggest that crosstalk induces wave interference in the skull and leads to the superposition of bilateral signals at the cochleae, resulting in these atypical lateralization patterns. This evidence highlights the inherent challenges of sound localization under BC compared to AC, identifying crosstalk-induced wave interference as a primary obstacle to improved spatial hearing for bilateral BCHD users.}, archive = {J_ADVS}, author = {Liu-Jie Ren and Yi Yu and Cheng Hua and You-Zhou Xie and Wen-Juan Yao and Jun-Yi Liang and Chen-Long Li and Tian-Yu Zhang}, doi = {10.1002/advs.202500302}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e00302}, shortjournal = {Adv. Sci.}, title = {Interference pattern caused by bilateral bone conduction stimulation impairs sound localization}, volume = {12}, year = {2025}, }
• (2025). Delivery of molecular hydrogen for precision immunomodulation: Mechanisms, detection methods, and applications. ADVS, 12(32), e00283. (www)

  @article{ , abstract = {The delivery of molecular hydrogen (H 2 ) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis. These effects contribute to a balanced and functional immune system, highlighting the therapeutic promise of H 2 in various inflammatory conditions. However, two critical issues remain unresolved: the unclear mechanism underlying the immunomodulatory effects of H 2 and the lack of precision detection methods to clarify the dose-efficacy relationship in vivo. Since previous reviews focused on developing nanomaterials for H 2 delivery, they often overlook analyses of the immunomodulation mechanisms and fail to update the detection methods. To address these gaps, a review that explores the immunomodulatory mechanisms of H 2 is proposed, the recent detection methods, and the classification and applications of advanced H 2 delivery systems, aiming to enhance the understanding of precision immunomodulation strategies leveraging their properties.}, archive = {J_ADVS}, author = {Gangfeng Li and Hannan Cui and Ruixiao Fan and Guming Liu and Zishuo Hou and Yibo Zhang and Xuanming Che and Tengjiao Wang and Hongbo Wei and Peng Li}, doi = {10.1002/advs.202500283}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e00283}, shortjournal = {Adv. Sci.}, title = {Delivery of molecular hydrogen for precision immunomodulation: Mechanisms, detection methods, and applications}, volume = {12}, year = {2025}, }
• (2025). Accounting for ALA natural mutations enhances the efficiency of graphene oxide nanopriming in bar-modified arabidopsis. ADVS, 12(32), e00058. (www)

  @article{ , abstract = {Environmental stress poses significant challenges to global agriculture, highlighting the need for resilient crops with optimized stress responses. Nanopriming and genetic modification technologies offer promising solutions. However, the differential effects of nanopriming on genetically modified (GM) and wild-type (WT) plants remain unexplored. Using natural α-linolenic acid (ALA) metabolism mutations as a reference, genetic variation influences resilience under graphene oxide (GO) priming is examined in Arabidopsis thaliana . GO priming increased chlorophyll content by 91.6% in WT plants and 29.6% in GM ( bar -gene) plants. Photosynthetic efficiency and quantum yield improved in the WT plants but declined in the GM plants. ALA metabolism mutations exacerbate lipid metabolism disruptions in GM plants, including altered jasmonic acid signaling and lipid composition, which compromise chloroplast integrity. Notably, transgenerational effects are observed in GM plants, with F1 seeds demonstrating dynamic epigenetic regulation of ALA metabolic genes, underscoring the influence of priming on stress resilience across generations. ALA supplementation enhanced the photosynthetic performance and chlorophyll content in WT and GM plants, with the GM plants exhibiting a significant increase of ≈60%. These findings emphasize the need for tailored nanopriming strategies that consider genetic variation and metabolic trade-offs, thereby advancing the development of resilient crops for sustainable agriculture.}, archive = {J_ADVS}, author = {Yining Wu and Rui Sun and Yueting Cui and Jun Qiao and Chengdong Zhang}, doi = {10.1002/advs.202500058}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {e00058}, shortjournal = {Adv. Sci.}, title = {Accounting for ALA natural mutations enhances the efficiency of graphene oxide nanopriming in bar-modified arabidopsis}, volume = {12}, year = {2025}, }
• (2025). Dual-energy CT-based assessment of thrombotic heterogeneity for predicting stroke source and response to machine thrombectomy: A step toward visualization thrombus treatment (Adv. sci. 32/2025). ADVS, 12(32), 71221. (www)

  @article{ , archive = {J_ADVS}, author = {Jingxuan Jiang and Sijia Wang and Fan Xiao and Hongmei Gu and Mingkang Wang and Hao Tian and Baohui Guan and Kai Sheng and Yijia Xiong and Huilin Zhao and Minda Li and Li Xu and Zheng Sun and Haiyan Du and Wenxian Du and Yuehua Li}, doi = {10.1002/advs.71221}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {71221}, shortjournal = {Adv. Sci.}, title = {Dual-energy CT-based assessment of thrombotic heterogeneity for predicting stroke source and response to machine thrombectomy: A step toward visualization thrombus treatment (Adv. sci. 32/2025)}, volume = {12}, year = {2025}, }
• (2025). Genomic and cis-regulatory basis of a plastic c3-c4 photosynthesis in eleocharis baldwinii (Adv. sci. 32/2025). ADVS, 12(32), 71220. (www)

  @article{ , archive = {J_ADVS}, author = {Lu Chen and Yanfeng Jia and Zaihui Zhou and Qiying Jiang and Jianlin Liu and Jianhui Gu and Chuan Chen and Shujing Cheng and Jinfang Chu and Xin Liu and Yongjun Lin and Xiang Li}, doi = {10.1002/advs.71220}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {71220}, shortjournal = {Adv. Sci.}, title = {Genomic and cis-regulatory basis of a plastic c3-c4 photosynthesis in eleocharis baldwinii (Adv. sci. 32/2025)}, volume = {12}, year = {2025}, }
• (2025). Structure, mechanics, and mechanobiology of fibrocartilage pericellular matrix mediated by type v collagen (Adv. sci. 32/2025). ADVS, 12(32), 71219. (www)

  @article{ , archive = {J_ADVS}, author = {Chao Wang and Mingyue Fan and Su Chin Heo and Sheila M. Adams and Thomas Li and Yuchen Liu and Qing Li and Claudia Loebel and Jason A. Burdick and X. Lucas Lu and David E. Birk and Farid Alisafaei and Robert L. Mauck and Lin Han}, doi = {10.1002/advs.71219}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {71219}, shortjournal = {Adv. Sci.}, title = {Structure, mechanics, and mechanobiology of fibrocartilage pericellular matrix mediated by type v collagen (Adv. sci. 32/2025)}, volume = {12}, year = {2025}, }
• (2025). Exome sequencing reveals the genetic architecture of non-syndromic orofacial clefts and identifies BOC as a novel causal gene (Adv. sci. 32/2025). ADVS, 12(32), 71218. (www)

  @article{ , archive = {J_ADVS}, author = {Qing He and Min Yu and Yuhua Jiao and Yizhu Xu and Xuqin Liang and Wenbin Huang and Linping Xu and Yuxia Hou and Zhanping Ren and Beile Lyu and Zhenwei Qian and Pengpeng Liu and Jing Zhou and Huimei Huang and Chunyan Yin and Huaxiang Zhao and Yi Ding}, doi = {10.1002/advs.71218}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {71218}, shortjournal = {Adv. Sci.}, title = {Exome sequencing reveals the genetic architecture of non-syndromic orofacial clefts and identifies BOC as a novel causal gene (Adv. sci. 32/2025)}, volume = {12}, year = {2025}, }
• (2025). Fully automated deep learning enabled miniature mass spectrometry system for psychoactive therapeutic drug monitoring (Adv. sci. 32/2025). ADVS, 12(32), 71217. (www)

  @article{ , archive = {J_ADVS}, author = {Yuanhao Zhou and Jiawen Ai and Zi Ye and Kexin Chen and JingXiong Lin and Zhenhua Zhang and Mi Luo and Benjie Zhou and Shijian Xiang and Jianhua Zhou and Xinming Huo}, doi = {10.1002/advs.71217}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {71217}, shortjournal = {Adv. Sci.}, title = {Fully automated deep learning enabled miniature mass spectrometry system for psychoactive therapeutic drug monitoring (Adv. sci. 32/2025)}, volume = {12}, year = {2025}, }
• (2025). Gentle label-free nonlinear optical imaging relaxes linear-absorption-mediated triplet (Adv. sci. 32/2025). ADVS, 12(32), 71216. (www)

  @article{ , archive = {J_ADVS}, author = {Geng Wang and Lianhuang Li and Janet E. Sorrells and Jianxin Chen and Haohua Tu}, doi = {10.1002/advs.71216}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {71216}, shortjournal = {Adv. Sci.}, title = {Gentle label-free nonlinear optical imaging relaxes linear-absorption-mediated triplet (Adv. sci. 32/2025)}, volume = {12}, year = {2025}, }
• (2025). Symmetry breaking in meniscus splitting: Effects of boundary conditions and polymeric membrane growth (Adv. sci. 32/2025). ADVS, 12(32), 71215. (www)

  @article{ , archive = {J_ADVS}, author = {Thi Kim Loc Nguyen and Taisuke Hatta and Koji Ogura and Yoshiya Tonomura and Kosuke Okeyoshi}, doi = {10.1002/advs.71215}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {71215}, shortjournal = {Adv. Sci.}, title = {Symmetry breaking in meniscus splitting: Effects of boundary conditions and polymeric membrane growth (Adv. sci. 32/2025)}, volume = {12}, year = {2025}, }
• (2025). A wearable in-pad diagnostic for the detection of disease biomarkers in menstruation blood (Adv. sci. 32/2025). ADVS, 12(32), 71213. (www)

  @article{ , archive = {J_ADVS}, author = {Lucas Dosnon and Thomas Rduch and Charlotte Meyer and Inge K. Herrmann}, doi = {10.1002/advs.71213}, journal = {Advanced Science}, month = {8}, number = {32}, pages = {71213}, shortjournal = {Adv. Sci.}, title = {A wearable in-pad diagnostic for the detection of disease biomarkers in menstruation blood (Adv. sci. 32/2025)}, volume = {12}, year = {2025}, }
• (2025). In situ proliferating peptide nanoparticle augments multi-target intervention of secondary brain damage following subarachnoid hemorrhage. ADVS, 12(31), e17456. (www)

  @article{ , abstract = {Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered by neuro-glial units for persistent neuroinflammation, oxidative damage and programmed neuronal cell death. Single-target and traditional multi-target therapies, derived from individual drugs, show limited efficacy in addressing these interconnected events, due to spatiotemporal heterogeneity of action in single-target components. This highlights the urgent need for not only new therapeutic targets, but advanced multi-target drugs. Herein, we identify elevated cell-free DNA (cfDNA), a key neuroinflammatory driver, as correlated with SAH severity and poor prognosis, suggesting its therapeutic potential. Furthermore, a novel “in situ proliferation” strategy is proposed and a flexible multi-target peptide nanoparticle is developed through co-assembling matrix metalloproteinase-2 responsive cationic peptide and glutathione peroxidase-mimicking peptide (GPXP). Upon reaching injury lesions, this system splits into two individual drugs: cationic peptide scavenges pathological cfDNA and inhibits microglia-mediated neuroinflammation, while GPXP protects neurons against oxidative damage and neuronal apoptosis/ferroptosis. Consequently, this strategy proves superior therapeutic effects on reducing secondary brain injury and promoting neurofunctional recovery in SAH mice. These findings not only highlight the essential role of cfDNA in SAH but offer a flexible resolution to advance multi-target combinational therapy.}, archive = {J_ADVS}, author = {Yibin Zhang and Peisen Yao and Fuxiang Chen and Shufa Zheng and Xuegang Niu and Haojie Wang and Yuanxiang Lin and Bin Gao and Dezhi Kang}, doi = {10.1002/advs.202417456}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e17456}, shortjournal = {Adv. Sci.}, title = {In situ proliferating peptide nanoparticle augments multi-target intervention of secondary brain damage following subarachnoid hemorrhage}, volume = {12}, year = {2025}, }
• (2025). Label-free 3D photoacoustic imaging of tumor organoids for volumetric drug screening. ADVS, 12(31), e17226. (www)

  @article{ , abstract = {As one of the most advanced in vitro drug screening platforms, tumor organoids require accurate pharmacosensitivity assessments to ensure reliable results. However, achieving accurate volume assessment of these 3D organoid models remains a challenge in traditional drug screening processes. Here, a label-free organoids photoacoustic imaging (LFOPI) system is introduced for high-resolution 3D imaging of tumor organoids. The capabilities of the LFOPI system are evaluated by monitoring structural transformations in melanoma organoids. The LFOPI system is further employed for volumetric drug screening of melanoma tumor organoids. Drug screening with cisplatin and temozolomide reveal that LFOPI-based organoid volume data correlates more strongly with viability trends (0.8627 and 0.9069) than traditional diameter-based methods (0.8190 and 0.7849). Additionally, immunotherapy drug screening demonstrates the capability of the system to precisely assess the 3D volumes of irregularly shaped organoids. This LFOPI system provides a promising method for label-free drug screening and personalized treatment.}, archive = {J_ADVS}, author = {Xiaofei Luo and Maike Chen and Han Shan and Xize Yu and Qibo Lin and Qian Tao and Xiongwei Wei and Changling Lv and Ziyan Chen and Fan Zhuo and Xi Zhu and Jiaxing He and Zhaoxi Li and Chunlong Fei and Jing Xu and Juan Su and Zeyu Chen and Shuang Zhao and Xiang Chen}, doi = {10.1002/advs.202417226}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e17226}, shortjournal = {Adv. Sci.}, title = {Label-free 3D photoacoustic imaging of tumor organoids for volumetric drug screening}, volume = {12}, year = {2025}, }
• (2025). JA-mediated regulation of amino acid homeostasis adjusts metabolic flux and enhances spider mite tolerance via the SlJAZ8-SlWRKY57-SlAVT6s module in tomato. ADVS, 12(31), e16717. (www)

  @article{ , abstract = {A crucial strategy employed by plants to enhance insect resistance is allocating amino acids into secondary metabolic pathways, ensuring the synthesis of specialized metabolites that confer resistance. The storage and redistribution of amino acids primarily occur in vacuole; therefore, transport mechanisms must exist to facilitate the directed extravasation of amino acids from vacuole to cytosol and feed them into secondary metabolism in response to stress. However, the specific amino acid transporter located in the vacuole responsible for amino acid distribution remains unclear. Here, we identify two tomato vacuolar amino acid transporters, SlAVT6A and SlAVT6B. SlAVT6A functions as the primary exporter, while SlAVT6B modulates transport capacity through SlAVT6A/SlAVT6B heterodimer formation. This system redirects amino acids to boost trichome density, terpene accumulation, and gibberellin synthesis, thereby strengthening defense against spider mites. Furthermore, SlWRKY57 coordinates both transporters by forming a complex with SlJAZ8, linking jasmonic acid (JA) signaling to amino acid homeostasis through metabolic reprogramming from primary to specialized pathways. The findings reveal a SlJAZ8-SlWRKY57-SlAVT6A/SlAVT6B module that enhances growth and resistance by allocating amino acid to secondary metabolic pathways, offering insights for improving resistance in metabolic-assisted breeding.}, archive = {J_ADVS}, author = {Yingchen Hao and Xiaolong Wang and Langchen Guo and Lijun Xiang and Enxi Luo and Peng Cao and Penghui Liu and Yue Zhong and Chun Li and Jun Lai and Jun Yang and Shouchuang Wang}, doi = {10.1002/advs.202416717}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e16717}, shortjournal = {Adv. Sci.}, title = {JA-mediated regulation of amino acid homeostasis adjusts metabolic flux and enhances spider mite tolerance via the SlJAZ8-SlWRKY57-SlAVT6s module in tomato}, volume = {12}, year = {2025}, }
• (2025). Post-translational modifications in cilia and ciliopathies. ADVS, 12(31), e16562. (www)

  @article{ , abstract = {Cilia are microtubule-based organelles that extend from the surface of most vertebrate cells, and they play important roles in diverse cellular processes during embryonic development and tissue homeostasis. Mutations in ciliary proteins are associated with a wide range of human diseases, collectively referred to as ciliopathies. The past decades have witnessed significant advances in the identification of post-translational modifications (PTMs) in ciliary proteins, as well as the enzymes responsible for the PTMs. For example, acetylation of α-tubulin at lysine 40 is essential for ciliary assembly and maintenance, while ubiquitination of centrosomal proteins, such as pericentriolar material 1, regulates ciliary disassembly. In addition, accumulating evidence has shown that PTMs are essential for modulating ciliary structure and function, and that dysregulation of these modifications leads to the development of ciliopathies. In this review, current knowledge of PTMs in ciliary proteins is summarized, and their roles in regulating ciliary formation, homeostasis, and signaling are highlighted. The contribution of aberrant ciliary PTMs to ciliopathies is also discussed, along with the potential of targeting PTMs for ciliopathy treatment, including pharmacological modulation of PTM-related enzymes or substrates, which may provide new avenues for therapeutic intervention in ciliopathies.}, archive = {J_ADVS}, author = {Jie Ran and Jun Zhou}, doi = {10.1002/advs.202416562}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e16562}, shortjournal = {Adv. Sci.}, title = {Post-translational modifications in cilia and ciliopathies}, volume = {12}, year = {2025}, }
• (2025). Split-aperture xolography – Linear volumetric photoactivation with short axial dimension and low out of focus excitation. ADVS, 12(31), e16105. (www)

  @article{ , abstract = {Spatially confined photo-excitation with the lowest possible activation of the remaining volume is of central importance for high-resolution high-density optical data storage, fluorescence microscopy, 3D-lithography, and 3D-printing. Two-photon absorption (2PA) enables such applications yet leads to slow processing speed due to the underlying non-linear absorption process. Here, Split-Aperture Xolography (SAX), is introduced which uses stepwise excitation of dual-color responsive molecules to initiate a linear volumetric photo-reaction process that is up to several orders of magnitude more efficient than 2PA. The capabilities of SAX are investigated in a scenario study for focusing systems with high numerical aperture (NA) using a Python implementation of vectorial diffraction theory. The intersecting half-cones generated by the split illuminated entrance aperture of the objective reduce the axial focal spot size of the activation distribution by up to a factor of two compared to 2PA targeting the same electronic transition. A steep average decline of the activation probability with the fifth power away from focus is found for a wide range of directions. This is significantly better in comparison to 2PA and prevents that undesired out-of-focus excitation events sum-up with subsequent irradiations. This approach is expected to be advantageous for volumetric methods at the nanoscale.}, archive = {J_ADVS}, author = {Martin Regehly and Stefan Hecht}, doi = {10.1002/advs.202416105}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e16105}, shortjournal = {Adv. Sci.}, title = {Split-aperture xolography – Linear volumetric photoactivation with short axial dimension and low out of focus excitation}, volume = {12}, year = {2025}, }
• (2025). Designing tunable DNA condensates to control membrane budding transformation in synthetic cells. ADVS, 12(31), e15510. (www)

  @article{ , abstract = {Wetting interactions between biomolecular condensates and lipid membranes have demonstrated great potential to induce large-scale membrane transformations in synthetic cells. However, the ability to functionalize existing condensates and control their interactions with membranes is limited, restricting their utility in engineering controlled wetting behavior. Here, fully programmable condensates based on DNA Y-motifs are introduced to engineer precisely tunable wetting behavior. In contrast to unmodified condensates that show no interaction with membranes, wetting of supported lipid bilayers (SLBs) can be induced by partial cholesterol-functionalization of DNA nanostructures. Incorporating photoactivatable DNA-lipid linker enables contact angles to be controlled over a wide range by varying UV exposure times. Furthermore, selective partitioning of small unilamellar vesicles (SUVs) into DNA condensates is demonstrated via programmable surface interactions. In giant unilamellar vesicles (GUVs), membrane wetting of enclosed condensates can be efficiently induced post-fabrication and results in outward budding. Thus, this work establishes programmable DNA condensates as a powerful platform for fine-tuned control over membrane-associated processes in synthetic cells, exceeding traditional approaches such as altering lipid composition or environmental conditions. Finally, the platform provides the possibility to design smart drug carriers for controlled substance delivery and release, and represents a customizable model to study condensate-membrane dynamics.}, archive = {J_ADVS}, author = {Nastasja Kaletta and Sophia Burick and Yusuf Qudbuddin and Petra Schwille}, doi = {10.1002/advs.202415510}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e15510}, shortjournal = {Adv. Sci.}, title = {Designing tunable DNA condensates to control membrane budding transformation in synthetic cells}, volume = {12}, year = {2025}, }
• (2025). PSMD14 stabilizes SLC7A11 to ameliorate glucocorticoid-induced osteoporosis by suppressing osteocyte ferroptosis. ADVS, 12(31), e14902. (www)

  @article{ , abstract = {Glucocorticoid-induced osteoporosis (GIOP) remains the most prevalent complication compromising bone health in patients undergoing glucocorticoid (GC) therapy. Despite its clinical significance, osteocyte death, a pivotal initiator of GC-driven bone metabolic imbalance, has received insufficient attention. This study identifies ferroptosis, an iron-dependent regulated cell death mechanism, as a novel pathological phenotype of osteocytes in GC microenvironments. Utilizing GPX4 conditional knockout mice and pharmacological ferroptosis inhibitors, this work demonstrates that osteocyte ferroptosis exacerbates GIOP progression. Metabolomic profiling reveals cystine insufficiency and glutathione depletion in GC-treated osteocytes. Mechanistically, GCs directly impede the deubiquitinase PSMD14 from binding to SLC7A11, thereby promoting SLC7A11 ubiquitination and proteasomal degradation, which sharply diminishes cystine uptake. Bone-targeting adeno-associated virus-mediated PSMD14 overexpression stabilized SLC7A11, attenuating both osteocytic ferroptosis and bone loss in GIOP mice. Through high-throughput virtual screening, this work identifies Pantethine as a potent PSMD14 activator that enhances deubiquitinase activity, restores SLC7A11 expression in osteocytes, and mitigates osteoporosis. Collectively, this study elucidates the role and mechanism of osteocyte ferroptosis in GIOP pathogenesis and proposes PSMD14-targeted therapy as a viable clinical strategy.}, archive = {J_ADVS}, author = {Yifeng Shi and Qian Tang and Sunren Sheng and Hongyi Jiang and Chen Jin and Chencheng Zhou and Chenglong Xie and Lin Zheng and Di Zhang and Hui Xu and Cong Xu and Haiwei Ma and Guangheng Xiang and Wenfei Ni and Xiaoyun Pan and Lei Yang and Huazi Xu and Yu Qian and Aimin Wu and Xiangyang Wang and Gang Zheng}, doi = {10.1002/advs.202414902}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e14902}, shortjournal = {Adv. Sci.}, title = {PSMD14 stabilizes SLC7A11 to ameliorate glucocorticoid-induced osteoporosis by suppressing osteocyte ferroptosis}, volume = {12}, year = {2025}, }
• (2025). A supramolecular material for controlling kiwifruit bacterial canker. ADVS, 12(31), e14752. (www)

  @article{ , abstract = {Kiwifruit, a nutritious fruit consumed globally, is affected by kiwifruit bacterial canker (KBC) caused by Pseudomonas syringae pv. actinidiae ( Psa ), which is a major biotic stress that adversely impacts its cultivation and production. KBC control is still challenging owing to the evolution of resistant populations of Psa , the environmental risks associated with copper bactericides, and lack of effective bactericides. Therefore, to develop novel and efficient bactericides against Psa , a matrine (MT)-5-methylsalicylic acid (5-OMESA) salt (MOS) is synthesized and its antibacterial activity is analyzed. The newly synthesized compound is more antibacterial against Psa than the commercial bactericide thiazole copper (TC). MOS significantly disrupts the membrane structure of Psa and penetrates the cells more efficiently. In addition, it has high affinities to the Psa FtsZ protein and DNA helicase, which probably contribute to its bactericidal activity. Subsequently, the encapsulation of MOS into a supramolecular nanocarrier hydroxypropyl-β-cyclodextrin (HPCD) and the fabrication of a nano formulation (MOS@HPCD) result in superior solubility, penetration, foliar deposition and wettability, sustained release, and prolonged protection against Psa . The in vitro and in vivo control efficiencies of MOS@HPCD against Psa are markedly enhanced compared to those of MOS. This study proposes a promising supramolecular material to control KBC.}, archive = {J_ADVS}, author = {Xile Deng and Qiang Bian and Mingqing Zhou and Le Xie and Jichuan Zhang and Tianqi Liu and Yizhuo Zhang and Li Zhang and Jiaheng Zhang and Lianyang Bai}, doi = {10.1002/advs.202414752}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e14752}, shortjournal = {Adv. Sci.}, title = {A supramolecular material for controlling kiwifruit bacterial canker}, volume = {12}, year = {2025}, }
• (2025). MYC binding near transcriptional end sites regulates basal gene expression, read-through transcription, and intragenic contacts. ADVS, 12(31), e14601. (www)

  @article{ , abstract = {The MYC oncoprotein regulates numerous genes involved in processes such as cell cycle control and mitochondrial and ribosomal structure and function. This requires heterodimerization with its partner, MAX, and binding to specific promoter and enhancer elements. Here, it is shown that MYC and MAX also bind near transcriptional end sites (TESs) of over one-sixth of all annotated genes. These interactions are dose-dependent, evolutionarily conserved, stabilize the normally short-lived MYC protein and regulate expression both in concert with and independent of MYC's binding elsewhere. MYC's TES-associated binding, occurring in coordination with other transcription factors, alters the chromatin landscape, increases nuclease susceptibility and alters transcriptional read-through, particularly in response to certain stresses. MYC-bound TESs can directly contact promoters and appear to fine-tune gene expression in response to both physiologic and pathologic stimuli. Collectively, these findings support a previously unrecognized role for MYC in regulating transcription and its read-through via direct intragenic contacts between TESs and promoters.}, archive = {J_ADVS}, author = {Huabo Wang and Bingwei Ma and Taylor Stevens and Jessica Knapp and Jie Lu and Edward V. Prochownik}, doi = {10.1002/advs.202414601}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e14601}, shortjournal = {Adv. Sci.}, title = {MYC binding near transcriptional end sites regulates basal gene expression, read-through transcription, and intragenic contacts}, volume = {12}, year = {2025}, }
• (2025). The nuclear localization of ACLY guards early embryo development through recruiting p300 and HAT1 to promote histone acetylation and transcription. ADVS, 12(31), e14367. (www)

  @article{ , abstract = {Metabolic processes and epigenetic reprogramming are intricately interconnected; however, their mechanistic interplay remains unclear. This study elucidates the role of ATP-citrate lyase (ACLY), an essential enzyme in acetyl-CoA production that uniquely localizes to the nucleus in oocytes and early embryos. Maternal Acly deletion in oocytes preserves fertility due to the compensatory upregulation of Acetyl-CoA Synthetase 2 (ACSS2), whereas zygotic Acly knockout causes developmental arrest at the pre-blastocyst stage without ACSS2 induction. Mechanistically, nuclear ACLY recruits and interacts with histone acetyltransferases, specifically E1A binding protein p300 (P300) and histone acetyltransferase 1 (HAT1), supplying acetyl-CoA for histone acetylation to activate transcription, which is essential for embryogenesis. Clinically, enhanced ACLY nuclear localization correlates with superior quality of human embryos. Functionally, AKT-mediated phosphorylation (Thr447/Ser451/Ser455) drives the nuclear translocation of ACLY and facilitates its interaction with HAT1 and P300. Inhibition of ACLY or its phosphorylation disrupts the promoting effects of AKT activators, such as insulin-like growth factor-1 (IGF-1), on blastocyst formation. These findings suggest that ACLY is a metabolic hub that bridges signaling and epigenetic remodeling, ensuring acetyl-CoA availability for chromatin modifications, and offering insights into the metabolic determinants of embryo viability and potential therapeutic targets for infertility.}, archive = {J_ADVS}, author = {Yerong Ma and Yingyi Zhang and Weijie Yang and Xiaomei Tong and Siya Liu and Yan Zhou and Mengjia Qiu and Huifang Jiang and Zhanhong Hu and Peipei Ren and Yan Rong and Mengru Lai and Jiamin Jin and Fei Huang and Liujian Ouyang and Feng Zhou and Heng-Yu Fan and Yin-Li Zhang and Songying Zhang}, doi = {10.1002/advs.202414367}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e14367}, shortjournal = {Adv. Sci.}, title = {The nuclear localization of ACLY guards early embryo development through recruiting p300 and HAT1 to promote histone acetylation and transcription}, volume = {12}, year = {2025}, }
• (2025). PTPN2 inhibition disrupts mitochondrial renewal and blocks TFRC-mediated mitophagy to exert anti-tumor activities in ALK-positive anaplastic large cell lymphoma. ADVS, 12(31), e14282. (www)

  @article{ , abstract = {Anaplastic large cell lymphoma (ALCL) is a heterogeneous subtype of T-cell lymphoma usually driven by genetic alterations affecting the anaplastic lymphoma kinase (ALK) gene. Despite the relatively favorable prognosis of ALK-positive (ALK + ) ALCL, approximately 30–40% of patients experience relapses or disease progression. This work identifies protein tyrosine phosphatase PTPN2 as a critical gene essential for the growth and survival of ALK + ALCL by CRISPR/Cas9 editing. PTPN2 depletion can significantly suppress tumor cell proliferation, induce apoptosis, and provoke cell cycle arrest. Mechanistically, PTPN2 negatively regulates transferrin receptor (TFRC) expression to promote mitochondrial renewal via PTEN induced kinase 1 (PINK1)-PRKN (parkin RBR E3 ubiquitin protein ligase)-mediated mitophagy. The process functions independently of ferroptosis. Interestingly, TFRC is directly regulated by the transcription factor hypoxia-inducible factor 1 alpha (HIF1A) in its promoter. Notably, an orally bioavailable potent PTPN2/N1 active-site inhibitor ABBV-CLS-484 (AC484) demonstrates significant therapeutic potential against ALK + ALCL by disturbing mitochondrial renewal and blocking TFRC-mediated PINK1-PRKN-dependent mitophagy to exert anti-tumor activities, providing critical insights into the selection of targeted treatment strategies for ALK + ALCL patients and a strong rationale for advancing AC484 into clinical trials.}, archive = {J_ADVS}, author = {Wei-Ting Wang and Zi-Wen Duan and Tong-Yao Xing and Wei Hua and Kai-Xing Du and Chun-Yu Shang and Yi-Fan Wu and Li Wang and Jian-Yong Li and Rui Gao and Jin-Hua Liang and Wei Xu}, doi = {10.1002/advs.202414282}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e14282}, shortjournal = {Adv. Sci.}, title = {PTPN2 inhibition disrupts mitochondrial renewal and blocks TFRC-mediated mitophagy to exert anti-tumor activities in ALK-positive anaplastic large cell lymphoma}, volume = {12}, year = {2025}, }
• (2025). Tailoring a functional synthetic microbial community alleviates fusobacterium nucleatum-infected colorectal cancer via ecological control. ADVS, 12(31), e14232. (www)

  @article{ , abstract = {Polymorphic microbiomes play important roles in colorectal cancer (CRC) occurrence and development. In particular, Fusobacterium nucleatum ( F. nucleatum ) is prevalent in patients with CRC, and eliminating it is beneficial for treatment. Here, multiple metagenomic sequencing cohorts are combined with multiomics to analyze the microbiome and related functional alterations. Furthermore, local human metagenome and metabolomics are used to discover commensal consortia. A synthetic microbial community (SynCom) is then designed by metabolic network reconstruction, and its performance is validated using coculture experiments and an AOM-DSS induced mouse CRC model. The sequencing result shows that F. nucleatum is more abundant in both the feces and tumor tissues of CRC patients. It causes alterations through various pathways, including microbial dysbiosis, lipid metabolism, amino acid metabolism, and bile acid metabolism disorders. The designed SynCom contains seven species with low competition interrelationship. Furthermore, the SynCom successfully inhibits F. nucleatum growth in vitro and achieves colonization in vivo. Additionally, it promotes F. nucleatum decolonization, and enhances tryptophan metabolism and secondary bile acid conversion, leading to reduced lipid accumulation, decreased inflammatory reaction, and enhanced tumor inhibition effect. Overall, the bottom-up designed SynCom is a controllable and promising approach for treating F. nucleatum -positive CRC.}, archive = {J_ADVS}, author = {Zhongkun Zhou and Mengyue Yang and Hong Fang and Baizhuo Zhang and Yunhao Ma and Yongyuan Li and Yingjie Liu and Zeying Cheng and Yuanchun Zhao and Zhenzhen Si and Hongmei Zhu and Peng Chen}, doi = {10.1002/advs.202414232}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e14232}, shortjournal = {Adv. Sci.}, title = {Tailoring a functional synthetic microbial community alleviates fusobacterium nucleatum-infected colorectal cancer via ecological control}, volume = {12}, year = {2025}, }
• (2025). RETRACTION: MYH10 combines with MYH9 to recruit USP45 by deubiquitinating snail and promotes serous ovarian cancer carcinogenesis, progression, and cisplatin resistance. ADVS, 12(31), e13557. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202513557}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e13557}, shortjournal = {Adv. Sci.}, title = {RETRACTION: MYH10 combines with MYH9 to recruit USP45 by deubiquitinating snail and promotes serous ovarian cancer carcinogenesis, progression, and cisplatin resistance}, volume = {12}, year = {2025}, }
• (2025). Real-time evolutionary landscape of the bronchial epithelium and corresponding dynamic immune cell alterations in lung squamous cell carcinogenesis. ADVS, 12(31), e13256. (www)

  @article{ , abstract = {The molecular mechanism by which tumor cells and their microenvironment evolve during lung squamous cell carcinoma (LUSC) carcinogenesis remains unclear, greatly limiting its early diagnosis and treatment effectiveness in patients. To replicate pathogenic processes and identify the determinants of cell evolution, a rat model is established using tobacco-derived carcinogens. Here, a series of single-cell transcriptome profiles of normal lung epithelium, hyperplasia, metaplasia, dysplasia, and squamous cell carcinoma in situ (CIS) to invasive squamous cell carcinoma (SCC) is presented. A large proportion of canonical copy number variations (CNVs) are detected in the hyperplasia/metaplasia stages, with their frequency increasing as the lesion progressed. Although bronchial epithelial cells exhibit substantial heterogeneity, three distinct cellular states are identified during their evolution into malignant cells. Immune sensing occurs at the earliest stages of cellular transformation. However, persistent exposure to carcinogens induces microenvironmental remodeling, which is characterized by monocyte-derived macrophage infiltration, plasmacytoid dendritic cell expansion, and progressive T-cell exhaustion. These findings depict the evolutionary trajectory of cancer and the immune microenvironment, emphasizing the need for CNV evaluation in early screening and immune-based therapy for lesions at a high risk of progression to LUSC.}, archive = {J_ADVS}, author = {Baohong Luo and Yuting Luo and Sicheng Chen and Tiantian Yang and Bixia Liu and Xiting Liao and Xiaoke Zheng and Tian Tian and Jinxu Liu and Qinru Zhan and Xiaohua Situ and Zhongpeng Xie and Yanxia Wang and Zhe-Sheng Chen and Honglei Chen and Zheng Yang and Zunfu Ke}, doi = {10.1002/advs.202413256}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e13256}, shortjournal = {Adv. Sci.}, title = {Real-time evolutionary landscape of the bronchial epithelium and corresponding dynamic immune cell alterations in lung squamous cell carcinogenesis}, volume = {12}, year = {2025}, }
• (2025). IncRNA-ZFAS1, an emerging gate-keeper in DNA damage-dependent transcriptional regulation. ADVS, 12(31), e12385. (www)

  @article{ , abstract = {Numerous long noncoding RNAs (lncRNAs) are generated in response to external stimuli, but the scope and functions of such activity are not known. Here, this study provides insight into how the transcription of lncRNAs is connected to DNA damage response by identifying the lncRNA ZFAS1 , which is required for cell cycle arrest, transcription regulation, and DNA repair. Mechanistically, ZFAS1 facilitates dynamic changes in hyperphosphorylated forms of the large subunit of RNA polymerase II (RNAPII) around transcription initiation sites by directly targeting the regulated genes. It is shown that extensive transcription shutdown and concomitant stimulated engagement of RNAPII-Ser2P are crucial for repair and cell survival upon genotoxic stress. Finally, ZFAS1 knockout in mice dampened nucleotide excision repair (NER) and led to kidney dysplasia. Overall, the findings extend the understanding of lncRNAs in DNA damage repair (DDR) and imply a protective role of lncRNA against DDR-deficient developmental disorders.}, archive = {J_ADVS}, author = {Jiena Liu and Qing Lu and Zixuan Fan and Jiahui Lin and Nan He and Xin Zhang and Zhaoya Han and Tingting Zhu and Zhenzhen Wu and Yingying Xu and Yuming Wang}, doi = {10.1002/advs.202412385}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e12385}, shortjournal = {Adv. Sci.}, title = {IncRNA-ZFAS1, an emerging gate-keeper in DNA damage-dependent transcriptional regulation}, volume = {12}, year = {2025}, }
• (2025). Alnustone ameliorates metabolic dysfunction-associated steatotic liver disease by facilitating mitochondrial fatty acid β-oxidation via targeting calmodulin. ADVS, 12(31), e11984. (www)

  @article{ , abstract = {Metabolic dysfunction-associated steatotic liver disease (MASLD), including its more severe manifestation metabolic dysfunction-associated steatohepatitis (MASH), poses global public health threats with limited therapeutics. Here, the role of alnustone is explored, a natural compound derived from the traditional Chinese herb Alpinia katsumadai Hayata, in the treatment of MASLD and MASH. It is shown that alnustone administration potently reduces serum triacylglycerol levels, reverses liver steatosis, and alleviates insulin resistance in both male and female MASLD mice. It also effectively ameliorates established fibrosis in MASH mice without any side effects. Mechanistically, hepatic lipidome profiling and energy metabolic assays reveal that alnustone facilitates mitochondrial fatty acid β-oxidation. Employing limited proteolysis-mass spectrometry (LiP-SMap) and further validation, calmodulin is identified as a direct molecular target of alnustone. Alnustone interacts with the Ca 2+ -binding site of calmodulin, leading to increased cytosolic and mitochondrial Ca 2+ levels and enhanced mitochondrial function, whereas liver-specific calmodulin knockdown abrogates alnustone's therapeutic effects. Moreover, calmodulin is downregulated in human livers of patients with MASLD and MASH, and is genetically associated with reduced MASLD risk. These findings establish alnustone as a promising natural compound and highlight calmodulin as a target for treating MASLD.}, archive = {J_ADVS}, author = {Shourui Hu and Xiaofan Liang and Yiming Qin and Yuxuan Li and Yue Liu and Congcong Liu and Zongxuan Lin and Chunxuan Geng and Yanqi Xu and Daimin Wei and Yingying Qin and Han Zhao and Yuqing Zhang and Zi-Jiang Chen}, doi = {10.1002/advs.202411984}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e11984}, shortjournal = {Adv. Sci.}, title = {Alnustone ameliorates metabolic dysfunction-associated steatotic liver disease by facilitating mitochondrial fatty acid β-oxidation via targeting calmodulin}, volume = {12}, year = {2025}, }
• (2025). Correction to “Hippo pathway activation in aged mesenchymal stem cells contributes to the dysregulation of hepatic inflammation in aged mice”. ADVS, 12(31), e09745. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202509745}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e09745}, shortjournal = {Adv. Sci.}, title = {Correction to “Hippo pathway activation in aged mesenchymal stem cells contributes to the dysregulation of hepatic inflammation in aged mice”}, volume = {12}, year = {2025}, }
• (2025). Correction to programmable macrophage vesicle based bionic self-adjuvanting vaccine for immunization against monkeypox virus. ADVS, 12(31), e09423. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202509423}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e09423}, shortjournal = {Adv. Sci.}, title = {Correction to programmable macrophage vesicle based bionic self-adjuvanting vaccine for immunization against monkeypox virus}, volume = {12}, year = {2025}, }
• (2025). Correction to “Metabolic intervention liposome boosted lung cancer radio-immunotherapy via hypoxia amelioration and PD-l1 restraint”. ADVS, 12(31), e09211. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202509211}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e09211}, shortjournal = {Adv. Sci.}, title = {Correction to “Metabolic intervention liposome boosted lung cancer radio-immunotherapy via hypoxia amelioration and PD-l1 restraint”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Silver telluride colloidal quantum dot solid for fast extended shortwave infrared photodetector”. ADVS, 12(31), e08611. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202508611}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e08611}, shortjournal = {Adv. Sci.}, title = {Correction to “Silver telluride colloidal quantum dot solid for fast extended shortwave infrared photodetector”}, volume = {12}, year = {2025}, }
• (2025). Elevated histone lactylation mediates ferroptosis resistance in endometriosis through the METTL3-regulated HIF1A/HMOX1 signaling pathway. ADVS, 12(31), e08220. (www)

  @article{ , abstract = {Endometriosis (EMs) is a chronic gynecologic condition characterized by the growth of endometrial stromal and glandular tissue outside the uterine cavity of unknown etiology. Currently, ferroptosis resistance, increased glycolysis, and increased lactate production are identified in EMs. Histone lactylation is a lactate-derived posttranslational modification that is recognized primarily for its role in epigenetic regulation. In this study, it is demonstrated that increased histone lactylation contributes to ferroptosis resistance in ectopic endometrial stromal cells (EESCs). Mechanistically, histone lactylation mediates ferroptosis resistance through the hypoxia-inducible factor 1 alpha (HIF1A)/heme oxygenase 1 (HMOX1) signaling pathway, which is regulated by methyltransferase like 3 (METTL3). In vivo experiments reveal that combination therapy with 2-deoxy-D-glucose (2-DG) and erastin is more effective for the treatment of EMs. Together, the findings provide a theoretical basis for the pathogenesis of EMs and suggest that a combined treatment that inhibits histone lactylation and induces ferroptosis is an effective treatment for EMs.}, archive = {J_ADVS}, author = {Zongwen Liang and Jinming Liu and Yanling Gou and Honglin Wang and Zhi Li and Yingying Cao and Huiyan Zhang and Ruru Bai and Zongfeng Zhang}, doi = {10.1002/advs.202408220}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e08220}, shortjournal = {Adv. Sci.}, title = {Elevated histone lactylation mediates ferroptosis resistance in endometriosis through the METTL3-regulated HIF1A/HMOX1 signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Unraveling the atomic mechanism of the crystalline phase-dependent structural features and special spectral design of α-, β-, and Ɛ-Ga₂O₃. ADVS, 12(31), e08207. (www)

  @article{ , abstract = {Atomic-scale phase transformations profoundly influence the functional properties of Ga₂O₃ polymorphs. By combining irradiation experiments with microstructure characterization and theoretical approaches, phase-specific energy-dissipation pathways in α-, β-, and ε-Ga₂O₃ are uncovered and strategies for targeted property design are outlined. Competing antiphase boundaries (APBs) and twin domain boundaries (TDBs) promote irreversible α→ε interconversion through domain fragmentation. In β-Ga₂O₃, defect-induced stress gradients drive two distinct local transformations: surface Ga-aggregated β→δ that stabilizes transient states, and latent-track-confined β→κ phase transition with recoverable distortions via cation reordering. Under electronic excitation, β-Ga₂O₃ forms nanohillocks via robust GaO₆ octahedra (high density/strong Ga─O bonds), while α/ε-Ga₂O₃ generates nanopores from tetrahedral Ga looseness (low bonding energy), highlighting phase-dependent surface dynamics shaped by atomic packing and bonding anisotropy. Defect-regulated recombination suppresses visible photoluminescence in α/β-Ga₂O₃, whereas in ε-Ga₂O₃ bandgap narrowing of ΔE: 0.30 eV is observed, enhancing emission. Linking phase-dependent defect-carrier interactions and metastable-phase engineering in Ga₂O₃ enables property optimization for power-electronics and optoelectronics devices.}, archive = {J_ADVS}, author = {Xinqing Han and Yong Liu and Yang Li and Miguel L. Crespillo and Eva Zarkadoula and Wenxiang Mu and Peng Liu}, doi = {10.1002/advs.202508207}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e08207}, shortjournal = {Adv. Sci.}, title = {Unraveling the atomic mechanism of the crystalline phase-dependent structural features and special spectral design of α-, β-, and Ɛ-Ga₂O₃}, volume = {12}, year = {2025}, }
• (2025). CO2-DBU-triggered photoredox-catalyzed direct α-C-H alkylation of alcohols. ADVS, 12(31), e07490. (www)

  @article{ , abstract = {An efficient photoinduced and metal-free method for direct α-C–H monoalkylation of alcohols utilizing the CO 2 -DBU-system as a hydrogen bond acceptor (HBA) catalyst in the presence of water (H 2 O) is reported. This protocol allows for selective functionalization of alcohols with a broad substrate scope, demonstrating yields up to 88% in 36 examples. Systematic computational analysis using DFT calculations reveals insights into the mechanism by identifying the key intermediates assembled via intermolecular hydrogen bond between DBU-CO 2 adduct and alcohol. This strategy opens new avenues for efficient alkylation of ordinary alcohols, offering an environmentally friendly approach to complex molecular synthesis.}, archive = {J_ADVS}, author = {Zeyu Zhang and Zongchang Han and Yuhao Shang and Han-Shi Hu and Jun Li and Chanjuan Xi}, doi = {10.1002/advs.202507490}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e07490}, shortjournal = {Adv. Sci.}, title = {CO2-DBU-triggered photoredox-catalyzed direct α-C-H alkylation of alcohols}, volume = {12}, year = {2025}, }
• (2025). Nanoplastics enhance transmembrane transport and uptake of carcinogens: Transcriptional changes and the effects of weathering. ADVS, 12(31), e07355. (www)

  @article{ , abstract = {Nanoplastics are generated from common consumer plastics (polyethylene terephthalate, high-density polyethylene, polystyrene, polyvinyl chloride) and exposed to simulated marine weathering for up to 10 weeks. Fourier-transform infrared spectroscopy and ζ-potential measurements reveal continuous changes in the composition of the nanoplastics, consistent with oxidation. Although the chemical composition and oxidation of the nanoplastics influence their ability to sorb polycyclic aromatic hydrocarbons (PAHs), for all investigated conditions, sorption of PAHs to nanoplastics achieves effective PAH concentrations that are orders of magnitude higher than the solubility limit in water. In an intestinal co-culture model membrane consisting of M cells and enterocytes, PAH-loaded nanoplastics enhance the overall PAH transport into and across the membrane, with HDPE achieving the highest intracellular PAH concentration. RNA sequencing of cell membranes exposed to nanoplastics reveals significant transcriptional changes, including upregulation of oxidative stress and detoxification pathways (NQO1, CYP1A1, CYP1B1), especially in response to PAH-loaded nanoplastics, while genes associated with basic cell functions, such as DNA repair (MACROD2) and division (KIF20A), are downregulated. These findings confirm the feasibility of nanoplastics to increase bioaccessibility and bioavailability of hydrophobic carcinogens and enhance cellular stress, which underscores the potential environmental and health impacts associated with nanoplastics as carriers of hydrophobic environmental toxins.}, archive = {J_ADVS}, author = {Erik B. Schiferle and Saatwik Suman and Katherine R. Steffen and Koustav Kundu and Aniqa N. Islam and Björn M. Reinhard}, doi = {10.1002/advs.202507355}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e07355}, shortjournal = {Adv. Sci.}, title = {Nanoplastics enhance transmembrane transport and uptake of carcinogens: Transcriptional changes and the effects of weathering}, volume = {12}, year = {2025}, }
• (2025). Quantum thermalization dynamics of fermi gases quenched to the BEC-BCS crossover. ADVS, 12(31), e07343. (www)

  @article{ , abstract = {Understanding nonequilibrium dynamics of strongly interacting quantum systems represents one of the most challenging problems in many-body physics. Here, quantum thermalization dynamics are explored in real-time in an ultracold Fermi gas suddenly quenched to the BEC-BCS crossover. When quenched to unitarity, it is observed that the cloud size remains unchanged in the early evolution while the momentum distribution emerges two prethermal states with a lifetime difference of two orders of magnitude in the early and intermediate stage before very slowly evolving to the final stationary state. It is revealed that a crossover momentum, at which the momentum distribution remains nearly unchanged, is determined by the thermal wavelength at high temperatures and the Fermi momentum while at low temperatures. It is identified that the universal prethermal dynamics scaling where momentum distributions with different temperatures collapse onto one curve. When quenched to the BEC side, the thermalization rapidly relaxes into a prethermal state and exhibits the low energy oscillation related to the molecular bound states. This work provides benchmarks for the study of quantum thermalization in strongly interacting fermionic many-body systems.}, archive = {J_ADVS}, author = {Licheng Yi and Shuxian Yu and Meimei Wu and Shujin Deng and Haibin Wu}, doi = {10.1002/advs.202507343}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e07343}, shortjournal = {Adv. Sci.}, title = {Quantum thermalization dynamics of fermi gases quenched to the BEC-BCS crossover}, volume = {12}, year = {2025}, }
• (2025). Correction to “SCD1 sustains homeostasis of bulge niche via maintaining hemidesmosomes in basal keratinocytes”. ADVS, 12(31), e07247. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202507247}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e07247}, shortjournal = {Adv. Sci.}, title = {Correction to “SCD1 sustains homeostasis of bulge niche via maintaining hemidesmosomes in basal keratinocytes”}, volume = {12}, year = {2025}, }
• (2025). Astrocytic ET-1 system determines microglia phenotype following spinal cord injury. ADVS, 12(31), e07215. (www)

  @article{ , abstract = {Microglia/macrophages accumulate at the lesion site by switching toward pro-inflammatory (M1)-dominant phenotype at the acute phase following spinal cord injury (SCI). Such biased polarization shapes the functional outcomes by expanding tissue damage. In the present study, the astrocytic endothelin-1 (ET-1) system is revealed to be immediately activated after SCI, driving microglia polarization toward M1, but suppressing toward M2 phenotype through activation of transcription coactivator YAP via ET A and ET B receptors. In addition, the activation of astrocytic ET-1 system results in elevation of blood plasma ET-1 level, suggesting a high diagnostic value. SCI-induced thrombin is pinpointed as a crucial activator of the astrocytic ET-1 system. The serine protease dramatically promotes the astrocytic expression of preproendothelin-1 (ppET-1) through protease-activated receptor-1 (PAR-1)/RhoA/NF-κB and PAR-1/MAPKs/NF-κB signal pathways. Meanwhile, it induces the expression of astrocytic endothelin-converting enzyme 1 (ECE-1) responsible for mature ET-1 processing. Pharmacological inhibitors of PAR-1 and ET-1 are shown to be highly efficient in microglia M1 phenotype reversion and favorable for the recovery of rat locomotor function after SCI. The findings have revealed a novel mechanism of M1 microglia/macrophages swarming at lesion sites at the acute phase following SCI, and provide potential therapeutic approaches for neuroinflammation by targeting the astrocytic ET-1 system.}, archive = {J_ADVS}, author = {Bingqiang He and Si Xu and Mengdi Li and Hui Li and Shaolan Li and Li Niu and Honghua Song and Rixin Cai and Yue Zhou and Zhilong Cao and Yingjie Wang and Yongjun Wang}, doi = {10.1002/advs.202507215}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e07215}, shortjournal = {Adv. Sci.}, title = {Astrocytic ET-1 system determines microglia phenotype following spinal cord injury}, volume = {12}, year = {2025}, }
• (2025). Rapamycin alleviates heart failure caused by mitochondrial dysfunction and SERCA hypoactivity in syntaxin 12/13 deficient models. ADVS, 12(31), e07210. (www)

  @article{ , abstract = {SYNTAXIN 12/13 (STX12), a member of the syntaxin protein family enriched in the brain and heart, plays important roles in vesicle recycling. Currently, the role of STX12 in cardiovascular physiology remains unclear. Using zebrafish and mice, it is shown that STX12 loss leads to pericardial edema, cardiac malformations, and heart failure. Stx12 depletion disrupts mitochondrial morphology, reduces iron and zinc levels, and impairs ATP production. Stx12 -deficient cardiomyocytes exhibit prolonged repolarization due to decreased sarcoplasmic reticulum Ca 2+ -ATPase (SERCA) activity. Treatment with rapamycin, an mTOR inhibitor, restores mitochondrial protein expression and function by prompting the TFEB-PGC1α axis, enhances SERCA activity via the CAMKII-phospholamban pathway, and reduces the expression of stress markers. These findings suggest that STX12 plays an important role in the energy metabolism and metal homeostasis of cardiomyocytes. Enhancing mitochondrial function, autophagy, and SERCA activity through the administration of rapamycin may provide a potential therapeutic approach for cardiomyopathies associated with STX12 deficiency and hypometabolism.}, archive = {J_ADVS}, author = {Run-Zhou Yang and Fang Li and Jiao Liu and Shu-Ang Li and Dan-Hua Liu and Zhuanbin Wu and Pei-Pei Liu and Wenju Liu and Bin Zhou and Cizhong Jiang and Haibing Zhang and Ying Yu and Jian-Sheng Kang}, doi = {10.1002/advs.202507210}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e07210}, shortjournal = {Adv. Sci.}, title = {Rapamycin alleviates heart failure caused by mitochondrial dysfunction and SERCA hypoactivity in syntaxin 12/13 deficient models}, volume = {12}, year = {2025}, }
• (2025). EGFR-TKIs induced DPP4 drives metabolic reprogramming of persister cells in lung cancer. ADVS, 12(31), e06950. (www)

  @article{ , abstract = {Mutations in epidermal growth factor receptor (EGFR) are the key drivers of lung cancer initiation and recurrence. The cancer cells undergo transformation to a reversible drug-tolerant persister (DTP) state prior to the development of resistance against EGFR-tyrosine kinase inhibitors (TKIs). Two DTP lung cancer cells with different proliferative capacities are established and identified dipeptidyl peptidase 4 (DPP4) as a potential therapeutic target. The DTP cells primarily relied on oxidative phosphorylation, which is accompanied by the up-regulation of fatty acid metabolism. Mechanistically, DPP4 facilitates the uptake of fatty acids via carnitine palmitoyl transferase 1a (CPT1A, and enhances fatty acid oxidation. In addition, the DPP4-mitogen-activated protein kinase kinase (MEK)-Nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway maintains mitochondrial function by activating the antioxidant pathway. The combination of osimertinib and sitagliptin, a DPP4 inhibitor, not only suppressed tumor progression but also reduced the number of residual tumor cells and minimal residual disease. Notably, this combination therapy significantly lowered recurrence rates and extended the survival of tumor-bearing mice compared to the monotherapies. The study provides new insights into the metabolic adaptations of DTP lung cancer cells in response to EGFR-TKIs, offering novel therapeutic strategies for targeting these persister cells.}, archive = {J_ADVS}, author = {Yuanzhou Zhang and Xiaojun Zhang and Xupeng Yang and Xingshi Chen and Yuehong Wang and Jingying Hu and Rui Liu and Xiaoying Luo}, doi = {10.1002/advs.202506950}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e06950}, shortjournal = {Adv. Sci.}, title = {EGFR-TKIs induced DPP4 drives metabolic reprogramming of persister cells in lung cancer}, volume = {12}, year = {2025}, }
• (2025). Decoupling ultralow coherent and particle-like phonon transport via bonding hierarchy in soft superionic crystals. ADVS, 12(31), e06807. (www)

  @article{ , abstract = {Within the unified theoretical framework for thermal transport, the inherent interplay between coherent tunneling and propagative phonon mechanisms establishes an antagonistic relationship, thereby imposing fundamental limitations on suppressing lattice thermal conductivity κ L $\rm \kappa _L$ . In this work, it is theoretically demonstrate that the superionic crystals X 6 Re 6 S 8 I 8 (X = Rb, Cs) exhibit ultralow glass-like and particle-like thermal conductivities. The weak interactions between free alkali metal ions X + (X = Rb, Cs) and I − anions induce pronounced lattice anharmonicity, which enhances phonon scattering and suppresses group velocities, thereby reducing the particle-like thermal conductivity ( ). Concurrently, the significant bonding heterogeneity within and between the [Re 6 S 8 I 6 ] 4 − clusters promotes phonon band flattening and low-frequency phonon localization. The resulting discretized phonon flat bands substantially diminish the glass-like thermal conductivity ( ). At room temperature, the total of X 6 Re 6 S 8 I 8 (X = Rb, Cs) falls below 0.2 W m −1 K −1 . Furthermore, the bonding characteristics between X + and I − anions induce an anomalous cation mass-independent stiffening of low-frequency phonon branches in this system, resulting in counterintuitive thermal transport behavior. This work elucidates fundamental mechanisms governing heat transfer in ultralow materials and establishes novel pathways for transcending conventional thermal conductivity limitations.}, archive = {J_ADVS}, author = {Wenjie Xiong and Hao Huang and Yu Wu and Xinji Xu and Geng Li and Zonglin Gu and Shuming Zeng}, doi = {10.1002/advs.202506807}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e06807}, shortjournal = {Adv. Sci.}, title = {Decoupling ultralow coherent and particle-like phonon transport via bonding hierarchy in soft superionic crystals}, volume = {12}, year = {2025}, }
• (2025). Enhanced band-crystal engineering drives superior power generation in GeTe. ADVS, 12(31), e06612. (www)

  @article{ , abstract = {Optimizing both electrical and thermal performance in thermoelectric (TE) materials is challenging due to the inherent coupling between carrier and phonon transport. To address this, targeted modulation of band structure and crystal lattice is achieved in the optimized Ge 0.885 Zr 0.02 Pb 0.08 Te 0.985 (Cu 2 Te) 0.015 sample. Zr/Pb incorporation optimizes the band structure and significantly enhances the Seebeck coefficient, while Pb-substituted Ge sites occupy a more symmetric geometric center, reducing Ge vacancies, increasing crystal symmetry, and facilitating delocalized carrier transport. This leads to optimized carrier-weighted mobility ( µ w ) ≈210 cm 2 V −1 S −1 (average power factor ≈30.3 µW cm −1 K −2 ). Moreover, the alteration of this geometric center enhances phonon anharmonicity, and multi-scale defect structures induced by multi-element doping provide abundant phonon scattering sources. Consequently, the sample exhibits significantly improved µ w / κ L values over pristine GeTe across the entire temperature range, with an improvement of ≈238% at 650 K. A peak zT of ≈2.2 at 650 K translates to a maximum heat-to-electricity conversion efficiency of up to 8.5% for a 7-pair device at Δ T = 366 K. This work further reveals the potential of synergistic band and crystal control engineering in decoupling carrier and phonon transport in GeTe-based materials, paving the way for broader applications of GeTe-based TE devices.}, archive = {J_ADVS}, author = {Xiaobo Tan and Qian Deng and Jianglong Zhu and Ruiheng Li and Xuri Rao and Fan Feng and Shuang Lyu and Pengfei Nan and Yue Chen and Binghui Ge and Ran Ang}, doi = {10.1002/advs.202506612}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e06612}, shortjournal = {Adv. Sci.}, title = {Enhanced band-crystal engineering drives superior power generation in GeTe}, volume = {12}, year = {2025}, }
• (2025). Self-adjusting engineered probiotic for targeted tumor colonization and local therapeutics delivery. ADVS, 12(31), e06486. (www)

  @article{ , abstract = {Engineered bacteria have demonstrated great potential for treating a broad array of tumors. However, the precision and safety of controlling the performance of engineered bacteria in vivo remains a central challenge. Here, genetic circuit programming strategy is utilized to construct an engineered Escherichia coli Nissle 1917 with accurate targeted colonizing and on-demand payloads releasing ability. The engineered probiotic survives only in the presence of more than 5 mM L-lactate by employing an improved lactate-sensing system, which leads to preventing the growth outside the permissive environments in mice. Meanwhile an expressing α-hemolysin (SAH) circuit based on quorum-sensing system is introduced to augment anti-tumor effect. Furthermore, coagulase (Coa) induced by high-level lactate creates the closure to deprive tumor of nutrients and oxygen and may help prevent the leakage of bacteria and SAH, which enhances the therapeutic effectiveness and biosafety. This self-adjusting living biotherapeutics significantly inhibits tumor proliferation and prolongs the survival time of colorectal tumor-bearing mice. Together, this work takes a step toward safer and more effective application of living bacteria for tumor treatment in practice.}, archive = {J_ADVS}, author = {Zhen-Ping Zou and Xin-Ge Wang and Xuan-Ren Shi and Shu-Ting Sun and Jing Mi and Xiao-Peng Zhang and Bin-Cheng Yin and Ying Zhou and Bang-Ce Ye}, doi = {10.1002/advs.202406486}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e06486}, shortjournal = {Adv. Sci.}, title = {Self-adjusting engineered probiotic for targeted tumor colonization and local therapeutics delivery}, volume = {12}, year = {2025}, }
• (2025). Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells. ADVS, 12(31), e06339. (www)

  @article{ , abstract = {Circulating tumor cells (CTCs) and their clusters are the cellular drivers of metastasis. This study uses microfluidic models mimicking human capillary bifurcations to better understand how these cells interact with capillary beds. Patient CTCs, CTC-derived explant cells, and numerous cancer cell lines shed nuclei-free fragments in a cell size- and bifurcation-dependent manner. These shedding events, which reduces cell sizes up to 61%, facilitate CTC transit through bifurcations. The shed fragments are a novel subclass of large extracellular vesicles (LEVs) that we name “shearosomes” based on their requirement of shear stress for their biogenesis, and whose proteome is associated with immune-related pathways. Shearosomes exhibit functions that are characteristic of previously identified extracellular vesicles (EVs), including cell-directed internalization by endothelial and immune cells, and intercellular communication capabilities such as disruption of endothelial barrier integrity, polarization of monocytes toward M2 tumor-promoting macrophages, and mediating interactions between endothelial and immune cells. These findings suggest that CTCs shed shearosomes within capillary beds that affect cells implicated in the metastatic cascade.}, archive = {J_ADVS}, author = {Angelos Vrynas and Salime Bazban-Shotorbani and Sara Arfan and Karishma Satia and Brian Cunningham and Gauhar Sagindykova and Mymuna Ashna and Aoyu Zhang and Diana Visan and Aisher Chen and Teige Matthews-Palmer and Mathew Carter and Fiona Blackhall and Kathryn L. Simpson and Caroline Dive and Paul Huang and Sam H. Au}, doi = {10.1002/advs.202506339}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e06339}, shortjournal = {Adv. Sci.}, title = {Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells}, volume = {12}, year = {2025}, }
• (2025). A needle-like H2S-releasing and H2O2 self-replenishing nanoplatform for enhanced chemodynamic tumor immunotherapy. ADVS, 12(31), e06282. (www)

  @article{ , abstract = {The tumor microenvironment (TME) significantly restricts chemodynamic therapy (CDT) efficacy through hypoxia and antioxidant defenses. An intelligent cascade nanosystem, PTA-SnS 2 @GOx, is developed by integrating a tannic acid-modified Prussian blue analogue core, SnS 2 shell, and glucose oxidase (GOx) activation module. The needle-like nanostructure enhanced tumor accumulation and cellular uptake. GOx-mediated glucose oxidation generated H 2 O 2 and gluconic acid, triggering pH-responsive H 2 S release from SnS 2 . This gas disrupted mitochondrial respiration and catalase activity, alleviating hypoxia while elevating intracellular H 2 O 2 levels. The oxygenated TME subsequently amplified GOx biocatalysis, establishing a self-sustaining cycle of H 2 O 2 production and acidification. Concurrently, Sn 4+ ions depleted glutathione, synergistically enhancing Fenton-like reactions in the PTA core for reinforced ROS generation. This multi-tiered strategy achieved effective CDT through the coordinated mechanisms: continuous H 2 O 2 self-supply, pH reduction, and redox homeostasis disruption. Notably, the nanosystem induced immunogenic cell death, promoting dendritic cell maturation and repolarizing tumor-associated macrophages from M2 to M1 phenotype, thereby remodeling immunosuppressive TME and activating systemic antitumor immunity. The synergistic integration of self-amplifying CDT with immune sensitization demonstrates superior tumor suppression in vivo. This study provided an intelligent paradigm for cancer theranostics by combining self-supplying H 2 S/H 2 O 2 -enhanced CDT with sensitized immunotherapy.}, archive = {J_ADVS}, author = {Xiaoxiao Sun and Xia Zhang and Haiyan Qin and Lingling Li}, doi = {10.1002/advs.202506282}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e06282}, shortjournal = {Adv. Sci.}, title = {A needle-like H2S-releasing and H2O2 self-replenishing nanoplatform for enhanced chemodynamic tumor immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Critical design strategy of thermogalvanic hydrogels for low-grade heat harvesting. ADVS, 12(31), e06038. (www)

  @article{ , abstract = {Low-grade heat, typically defined as heat at temperatures below 100 °C, is abundant and ubiquitous in the daily environment. However, it is often wasted due to the lack of efficient recovery methods. Thermocells (TECs), which leverage the thermogalvanic effect, provide a promising solution for directly converting low-grade heat to electricity. Recently, thermogalvanic hydrogels (THs) have emerged as an innovative class of materials for high-performance TECs due to their giant thermopower, high flexibility, biocompatibility, and low cost. This review comprehensively summarizes the latest advancement in TH research, with a particular focus on the promising design strategies. First, the fundamental mechanisms underlying thermoelectrochemical conversion in THs are systematically scrutinized. Second, the key metrics are outlined for evaluating TECs. Third, current strategies are highlighted for enhancing the thermoelectrochemical performance of THs, including the modifications of polymer matrix, liquid phase, additives, and others. Additionally, the current applications of TH-based devices are examined in energy harvest and sensing. Finally, the remaining challenges are discussed in the field and provide a forward-looking perspective on the future development of THs.}, archive = {J_ADVS}, author = {Wentao Lin and Shukai Wu and Shuo Niu and Zhe Hu and Guangming Chen and Zhuoxin Liu and Yang Huang and Chao Fang}, doi = {10.1002/advs.202506038}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e06038}, shortjournal = {Adv. Sci.}, title = {Critical design strategy of thermogalvanic hydrogels for low-grade heat harvesting}, volume = {12}, year = {2025}, }
• (2025). Tumor small extracellular vesicle-transmitted LncRNA CATED promotes platinum-resistance in high-grade serous ovarian cancer. ADVS, 12(31), e05963. (www)

  @article{ , abstract = {High-grade serous ovarian cancer (HGSOC) is the most lethal type of gynecological cancer, and platinum-resistance is a serious challenge in its treatment. Long non-coding RNAs (lncRNAs) play critical regulatory roles in the occurrence and development of cancers. Here, using RNA sequencing of tumor small extracellular vesicles (sEVs) from HGSOC patients, the lncRNA CATED is identified as significantly upregulated in both tumors and tumor-derived sEVs in platinum-resistant HGSOC, and low CATED levels correlate with good prognosis. Functionally, CATED enhances cisplatin resistance by promoting cell proliferation and inhibiting apoptosis in vitro and in vivo. These effects could be transferred via CATED-overexpressing sEVs from donor cells and HGSOC tumor sEVs. Mechanistically, CATED binds to and upregulates DHX36 via PIAS1-mediated SUMOylation at the K105 site, and elevated DHX36 levels increase downstream RAP1A protein levels by enhancing RAP1A mRNA translation, consequently activating the MAPK pathway to promote platinum-resistance in HGSOC. Antisense oligonucleotide mediated knockdown of CATED reverse platinum-resistance in sEV-transmitted mouse models via the DHX36-RAP1A-MAPK pathway. This study newly identifies a sEV-transmitted lncRNA CATED in driving HGSOC platinum-resistance and elucidates the mechanism it regulates the interacting protein through SUMOylation. These findings also provide a novel strategy for improving chemotherapy in HGSOC by targeting CATED.}, archive = {J_ADVS}, author = {Yi Liu and Hanyuan Liu and Chenchen Zhu and Yan Yang and Zhen Shen and Ge Shan and Liang Chen and Ying Zhou}, doi = {10.1002/advs.202505963}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05963}, shortjournal = {Adv. Sci.}, title = {Tumor small extracellular vesicle-transmitted LncRNA CATED promotes platinum-resistance in high-grade serous ovarian cancer}, volume = {12}, year = {2025}, }
• (2025). Quantum geometric engineering of dual hall effects in 2D antiferromagnetic bilayers via interlayer magnetic coupling. ADVS, 12(31), e05860. (www)

  @article{ , abstract = {The interplay between quantum geometry and magnetic order offers a novel strategy for designing next-generation nanodevices. Here, it is demonstrated that interlayer magnetic coupling in two-dimensional (2D) CoPSe 3 bilayers enables precise control over quantum geometric mechanisms, unlocking dual intrinsic Hall effects. The first-principles calculations reveal that the altermagnetic (AM) phase exhibits a giant anisotropic anomalous Hall effect (AHE) (σ xy ≈46 S cm −1 ) driven by Berry curvature localized at generic k -points, while the -symmetric antiferromagnetic (AFM) phase hosts an intrinsic second-order nonlinear anomalous Hall effect (NAHE) (χ xyy ≈ 160 µS V −1 ) originating from quantum metric accumulation at high-symmetry k -points. By tuning interlayer magnetic couplings, reversible switching between these phases is achieved, leveraging their distinct band structures and symmetry constraints. The Néel-vector-dependent AHE in the AM phase and the symmetry-protected NAHE in the AFM phase highlight quantum geometry as a versatile tool for manipulating transport properties. This work establishes 2D antiferromagnets as a promising platform for multifunctional device architectures, bridging linear and nonlinear magnetoelectric responses through tailored quantum geometric engineering.}, archive = {J_ADVS}, author = {Zhenning Sun and Tao Wang and Hao Jin and Xinru Li and Yadong Wei and Jian Wang}, doi = {10.1002/advs.202505860}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05860}, shortjournal = {Adv. Sci.}, title = {Quantum geometric engineering of dual hall effects in 2D antiferromagnetic bilayers via interlayer magnetic coupling}, volume = {12}, year = {2025}, }
• (2025). Correction to “Ammoniating covalent organic framework (COF) for high-performance and selective extraction of toxic and radioactive uranium ions”. ADVS, 12(31), e05740. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202505740}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05740}, shortjournal = {Adv. Sci.}, title = {Correction to “Ammoniating covalent organic framework (COF) for high-performance and selective extraction of toxic and radioactive uranium ions”}, volume = {12}, year = {2025}, }
• (2025). Stimuli-responsive MXene/PNIPAM hydrogel WITH high-performance and tunable electromagnetic interference shielding performance. ADVS, 12(31), e05551. (www)

  @article{ , abstract = {Smart electromagnetic interference (EMI) shielding materials capable of reversible EMI response hold great promise for application in flexible electromagnetic devices. Here, PPM hydrogels composed of poly (N-isopropylacrylamide) (PNIPAM) and MXene/PEDOT: PSS hybrid fillers are fabricated via ice-templated freeze-in-situ polymerization. The anisotropic structural design of the hydrogel enhances its mechanical properties, conductivity, and EMI shielding properties in a specific direction. Furthermore, it can rapidly adjust its internal water content under thermal and light stimulation. The EMI shielding performance of PPM hydrogels can transition from an EMI shielding status (EMI shielding on, >50 dB) to an EM-wave-transparent status (EMI shielding off, ≈2 dB) in the X-band with the dynamic change in water content. Notably, the EMI SE value of PPM hydrogel in the X-band can be quantitatively adjusted from ≈59.3 to 15.5 dB, demonstrating excellent repeatability and adjustability. A real-time electrical switching capability in the broad GHz frequency range (8.2–40 GHz) is achieved through dual stimuli-responsive (temperature-responsive and light-responsive) modulation. This study presents a new model for dynamically switchable EMI shielding and reveals the great application potential of smart on/off switchable hydrogel-based EMI shielding materials as next-generation multifunctional electronics.}, archive = {J_ADVS}, author = {Qian Yan and Zonglin Liu and Jinhua Xiong and Huanxin Lian and He Chen and Teng Fei and Yunxiang Chen and Haowen Zheng and Xu Zhao and Liangliang Xu and Fuhua Xue and Yesheng Zhong and Xiaoliang Ma and Liping Shi and Qingyu Peng and Xiaodong He}, doi = {10.1002/advs.202505551}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05551}, shortjournal = {Adv. Sci.}, title = {Stimuli-responsive MXene/PNIPAM hydrogel WITH high-performance and tunable electromagnetic interference shielding performance}, volume = {12}, year = {2025}, }
• (2025). Molten-salt-mediated synthesis of atomic Manganese/Cobalt catalysts on bioceramic microparticles for catalytic anti-osteoarthritis treatments. ADVS, 12(31), e05500. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a chronic progressive joint disease characterized by cartilage degeneration and local inflammation, and its progression is closely related to the excessive production of reactive oxygen species (ROS). Despite progress made with small molecule antioxidants and nanozymes, effective antioxidant therapy for the long-term elimination of these ROS remains challenging, largely due to the rapid clearance of antioxidants from the joints via synovial vessels and lymphatics. Herein, a molten-salt method is developed to facilitate the atomic dispersion of Mn or Co ions homogeneously on the surface of akermanite microparticles (AKT-MPs). The micrometer-scale Mn- or Co-AKT-MPs with multi-mimetic enzyme effects are demonstrated to obliterate multiple ROS, thereby protecting the inherent homeostasis between chondrocyte anabolism and catabolism, while suppressing the conversion of macrophages to a pro-inflammatory phenotype. In addition, the microparticles exhibited chondroprotection of ROS-challenged cartilage explants in vitro by limiting the loss of cartilage extracellular matrix (ECM) and the release of degradative enzymes. Furthermore, Mn- or Co-AKT-MPs are injected intra-articularly into monosodium iodoacetate (MIA)-induced OA mice and effectively suppress synovial inflammation, painful symptoms, and progression of early cartilage destruction. Therefore, this microparticle-based antioxidant therapy provides an insight and paradigm to control atomic catalysts integrated with microparticles for efficient catalytic anti-OA treatments.}, archive = {J_ADVS}, author = {Ronghui Deng and Zining Zhang and Aijun Wu and Chaoqin Shu and Shitang Song and Fuzhen Yuan and Zijie Xu and Meng Yang and Jing Ye and Yifan Song and Yufang Zhu and Jia-Kuo Yu}, doi = {10.1002/advs.202505500}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05500}, shortjournal = {Adv. Sci.}, title = {Molten-salt-mediated synthesis of atomic Manganese/Cobalt catalysts on bioceramic microparticles for catalytic anti-osteoarthritis treatments}, volume = {12}, year = {2025}, }
• (2025). In vivo dynamic coronary arteries blood flow imaging based on multi-cycle phase clustering ultrafast ultrasound. ADVS, 12(31), e05485. (www)

  @article{ , abstract = {Echocardiography is the most primary clinical modality for dynamic cardiac imaging. However, the vigorous motion of myocardial tissue inherently causes inevitable signal aliasing between blood flow and myocardial tissue in traditional Doppler ultrasound imaging, constituting a persistent challenge in echocardiography for decades. Particularly for low-velocity flows like coronary artery blood flow, the Doppler frequency shifts completely overlap with myocardial tissue signal shifts, rendering them virtually undetectable through conventional echocardiography. This study pioneers a paradigm shift by abandoning traditional Doppler-based blood flow imaging, and develops a novel multi-cycle phase clustering method for tissue clutter suppression, successfully extracting dynamic cardiac blood flow signals with clear visualization of both coronary artery flow and cardiac chamber flow throughout the full cardiac cycle. Furthermore, through integration with super-resolution ultrasound reconstruction techniques, enhanced spatial resolution in cardiac blood flow imaging is achieved. This breakthrough establishes a novel in vivo cardiovascular flow imaging approach characterized by high spatio-temporal resolution, safety, and clinical accessibility, demonstrating significant potential for advancing the diagnosis of cardiovascular diseases.}, archive = {J_ADVS}, author = {Hao Yu and Jiabin Zhang and Feng Feng and Jinyu Yang and Yu Xia and Yunlong Zhao and Jue Zhang}, doi = {10.1002/advs.202505485}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05485}, shortjournal = {Adv. Sci.}, title = {In vivo dynamic coronary arteries blood flow imaging based on multi-cycle phase clustering ultrafast ultrasound}, volume = {12}, year = {2025}, }
• (2025). Skeleton enhanced dispersed lubricant particle based triboelectric nanogenerator for droplet energy harvesting. ADVS, 12(31), e05363. (www)

  @article{ , abstract = {Liquid–solid triboelectric nanogenerators (LS-TENGs) can be widely utilized for droplet energy harvesting, in which slippery modification of triboelectric layer is crucial for output enhancement. However, classical slippery lubricant-infused surfaces suffer from the blocked triboelectric effect and the poor durability. Herein, a controllable phase separation method is reported to disperse skeleton-enhanced lubricant particles on triboelectric layer, leading to the development of a stretchable slippery triboelectric nanogenerator (SS-TENG) based on a modified slippery triboelectric layer and a liquid metal electrode. The dispersed lubricant particles (DLPs) ensure triboelectric effect between droplet and triboelectric layer, in addition to improving energy harvesting and charge transfer efficiencies. As a result, the open circuit voltage significantly increases from 0.9 to 14.4 V, with a transfer charge density of 6.95 × 10 −3 C m −2 L −1 . The embedded skeleton within lubricant particle significantly improves the durability of triboelectric layer, ensuring nearly no decline in output performance of SS-TENG during long-term operation. Furthermore, the SS-TENG exhibits stable output even under 300% stretching, as the DLPs remain firmly anchored to triboelectric layer during deformation. Owing to its excellent triboelectric performance, durability, and flexibility, the SS-TENG can be integrated into various objects to harvest raindrop energy and power electronic devices.}, archive = {J_ADVS}, author = {Changjun Yang and Yan Wang and Yamei Wang and Zelinlan Wang and Yurun Guo and Liwen Zhang and Xiaolin Liu and Huawei Chen}, doi = {10.1002/advs.202505363}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05363}, shortjournal = {Adv. Sci.}, title = {Skeleton enhanced dispersed lubricant particle based triboelectric nanogenerator for droplet energy harvesting}, volume = {12}, year = {2025}, }
• (2025). High voltage flexible sodium-ion battery cathode materials based on 1D covalent organic framework. ADVS, 12(31), e05311. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have emerged as promising electrode materials for sodium-ion batteries (SIBs) due to their well-ordered porous structures that facilitate ion storage and transport. However, conventional 2D and 3D COFs often require post-processing, such as ball milling or carbon compositing, to enhance electrochemical performance. In this study, a 1D imine-linked COF, N , N , N ′, N ′-Tetrakis(4-aminophenyl)-1,4-phenylenediamine-2,6-pyridinedicarboxaldehyde (TP-PDA), is synthesized via a one-step Schiff base reaction, achieving a fully conjugated and porous structure that enables efficient sodium-ion transport. TP-PDA is insoluble in organic electrolytes, ensuring stable cycling performance. The material exhibits a high average discharge potential of 3.1 V and delivers a discharge capacity of 124 mAh g −1 at 3 A g −1 after 1800 cycles, with a capacity retention exceeding 90%. In a full-cell configuration with a hard carbon anode, the battery maintains a stable capacity of 122 mAh g −1 after 10 000 cycles at 1 A g −1 without noticeable capacity degradation. Furthermore, the flexible pouch cell retains its electrochemical integrity under bending conditions, demonstrating its potential for flexible and wearable energy storage applications.}, archive = {J_ADVS}, author = {Shuai Liu and Puiki Leung and Yong Zuo and Meng Sun and Lei Wei and Frank C Walsh and Tianshou Zhao and Qiang Liao}, doi = {10.1002/advs.202505311}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05311}, shortjournal = {Adv. Sci.}, title = {High voltage flexible sodium-ion battery cathode materials based on 1D covalent organic framework}, volume = {12}, year = {2025}, }
• (2025). Bistable multi-layer triboelectric nanogenerator for harvesting random and ultra-low-frequency vibration energy with increased charge transfer. ADVS, 12(31), e05246. (www)

  @article{ , abstract = {Approximately 70% of the Earth’s surface is covered by seawater, making the ocean ideal for harvesting energy. Triboelectric nanogenerators (TENGs), due to their low cost and simple structure, are well-suited for capturing ocean energy. However, their low charge transfer under weak inputs limits efficiency in harvesting random and ultra-low-frequency wave energy. This paper proposes a novel bistable multi-layer TENG (BM-TENG) to address this challenge for self-powered wireless sensing and lighting. Simulations and experiments demonstrate that both in intra-well and inter-well motions, the bistable mechanism enhances the dynamic responses and thus the power output by up to 48%. Furthermore, the multi-layer design within the constrained structure significantly boosts the power density. Experimental results show 730 V peak-to-peak open-circuit voltage and 5 mW maximum power in a three-layer BM-TENG under the excitation of 0.6 Hz and 0.18 g. The normalized power density of the proposed device is 54.9 Wm −3 ·Hz −1 , surpassing the state-of-the-art results in literature. The application test shows that BM-TENG can successfully power 296 LEDs for ocean warning lighting, and power Bluetooth wireless sensors for monitoring marine environmental variables. This work introduces a novel and highly efficient self-powered sensing technique for advancements in marine Internet of Things (IoT) systems.}, archive = {J_ADVS}, author = {Yi Guan and Xin Li and Zehan Wei and Mianxin Xiao and Zhihui Lai and Shuxiang Dong and Daniil Yurchenko and Shitong Fang}, doi = {10.1002/advs.202505246}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05246}, shortjournal = {Adv. Sci.}, title = {Bistable multi-layer triboelectric nanogenerator for harvesting random and ultra-low-frequency vibration energy with increased charge transfer}, volume = {12}, year = {2025}, }
• (2025). Label-free single-molecule immunoassay. ADVS, 12(31), e05207. (www)

  @article{ , abstract = {Single-molecule immunoassay is a reliable technique for the detection and quantification of low-abundance blood biomarkers, which are essential for early disease diagnosis and biomedical research. However, current single-molecule methods predominantly rely on endpoint detection and necessitate signal amplification via labeling, which brings a variety of unwanted effects, like matrix effect and autofluorescence interference. This study introduces a real-time mass imaging-based label-free single-molecule immunoassay (LFSMiA). Featuring plasmonic scattering microscopy-based mass imaging, a 2-step sandwich assay format enables background reduction, minimization of matrix effect by dynamic tracking of single binding events, and fully leveraging real-time data for improved measurement precision through a Bayesian Gaussian process model, the LFSMiA enables ultra-sensitive and direct protein detection at the single-molecule level in neat blood sample matrices. LFSMiA measurement is demonstrated for interleukin-6 and prostate-specific antigen in buffer, undiluted serum, and whole blood with sub-femtomolar detection limits and eight logs of dynamic ranges. Moreover, comparable performance is achieved with an inexpensive miniaturized setup. To show its translational potential to clinical settings and point-of-care diagnostics, N-terminal pro-B-type natriuretic peptide is examined in patient whole blood samples using the LFSMiA and results in a strong linear correlation (r > 0.99) with standard clinical lab results.}, archive = {J_ADVS}, author = {Xiaoyan Zhou and Chao Chen and Shuang Zhou and Guangzhong Ma and Mohammad Javad H. N. Chemerkouh and Christine L. H. Snozek and Eric H. Yang and Jiapei Jiang and Brandyn Braswell and Zijian Wan and Xinyu Zhou and Shaopeng Wang}, doi = {10.1002/advs.202505207}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05207}, shortjournal = {Adv. Sci.}, title = {Label-free single-molecule immunoassay}, volume = {12}, year = {2025}, }
• (2025). Precise modulation of reorganization energy through methyl substitution for high performance organic solar cells. ADVS, 12(31), e05143. (www)

  @article{ , abstract = {Efficient charge transport and minimized energy loss are critical for advancing the performance of organic solar cells (OSCs). In this study, a series of quinoxaline-based electron acceptors, BQx-MeF, BQx-MeCl, and BQx-MeBr, featuring methyl and halogen substitutions is designed and synthesized to systematically modulate reorganization energy (λ) and film morphology. Quantum chemical calculations confirmed that methylation effectively reduces λ by limiting structural relaxation, leading to suppressed non-radiative recombination energy loss (Δ E nr ) and improved charge transport. Among the synthesized materials, BQx-MeCl exhibited the lowest energy loss and the most balanced electron and hole mobilities, resulting in a superior power conversion efficiency (PCE) of 19.2% in a binary device. In optimized ternary OSCs, BQx-MeCl further reached a remarkable PCE of 19.6%. This enhancement is attributed to optimized molecular stacking, improved film morphology, and reduced trap-assisted recombination. These findings highlight the pivotal role of molecular design in lowering reorganization energy to minimize energy losses and maximize charge collection, offering an effective strategy for the development of high-efficiency OSCs.}, archive = {J_ADVS}, author = {Li Chen and Chaoyue Zhao and Joshua Yuk Lin Lai and Rongkun Zhou and Aleksandr Sergeev and Kam Sing Wong and Huawei Hu and Zilong Zheng and Han Yu and Sai Ho Pun and Guangye Zhang and He Yan}, doi = {10.1002/advs.202505143}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05143}, shortjournal = {Adv. Sci.}, title = {Precise modulation of reorganization energy through methyl substitution for high performance organic solar cells}, volume = {12}, year = {2025}, }
• (2025). Transparent and transient flexible electronics. ADVS, 12(31), e05133. (www)

  @article{ , abstract = {Transparent electronics has gained tremendous attention in recent years because of the growing demand for see-through devices in applications such as displays, windscreens, and wearables. These applications require transparent electronics in a large area and flexible form factors along with performances at par with conventional electronics. Additionally, the controlled transience and degradability of electronics are desired to reduce the end-of-life challenges. Attaining these attributes simultaneously is challenging as inherent material properties do not always align well, and there are technological limitations such as thermal budget issues in the case of flexible substrates. As a result, several materials and structures, including 1D nanowires, 2D nanosheets, metal oxides, and polymers etc., are explored. This comprehensive review discusses these developments related to transparent electronics as well as the challenges associated with the development of flexible and transient transparent electronics over large areas. Potential solutions to overcome these challenges and various resource-efficient deposition and printing technologies are also presented along with examples of reported transparent circuits, sensors, actuators, and energy devices. Finally, potential future directions are discussed for flexible transient transparent electronics as their ever-growing demand could lead to the emergence of new materials, fabrication techniques, and applications.}, archive = {J_ADVS}, author = {Nitheesh M. Nair and Ayoub Zumeit and Ravinder Dahiya}, doi = {10.1002/advs.202505133}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05133}, shortjournal = {Adv. Sci.}, title = {Transparent and transient flexible electronics}, volume = {12}, year = {2025}, }
• (2025). A ROS-responsive dual-targeting drug nanocarrier serving as a GSI synergist and ferroptosis sensitizer for T-cell acute lymphoblastic leukemia. ADVS, 12(31), e05087. (www)

  @article{ , abstract = {T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematological malignancy for which targeted therapies remain underdeveloped. Oncogenic mutations in Notch1 occur in up to 75% of T-ALL patients. Although γ-secretase inhibitors (GSIs) can block Notch1 activation, their clinical application is limited by side effects and reduced sensitivity. Here, a self-assembling, reactive oxygen species (ROS)-responsive nanotherapeutic strategy—PHD/G-NPs—co-loaded with GSI and controlled released dihydroartemisinin (DHA), and modified with a CD38 antibody is reported. The CD38 antibody specifically targets T-ALL cells, while GSI selectively inhibits Notch1, resulting in a dual-targeting approach. GSI is released first, inhibiting Notch1 activation and inducing the death of a subset of T-ALL cells. To eliminate semi-quiescent T-ALL cells that escape initial therapy by elevating ROS levels, a ROS-sensitive DHA delivery system is employed to enhance ferroptosis and boost GSI efficacy. After elucidating the mechanism of action of PHD/G-NPs in T-ALL cells, PHD/G-NPs are combined with αPD-1, which triggers an anti-tumor immune response in vivo. This dual-targeting strategy using CD38-modified PHD/G-NPs enables controlled drug release, enhances ferroptosis, mitigates GSI-induced gastrointestinal toxicity, and improves therapeutic efficacy. This nanomedical approach offers a novel strategy for targeted T-ALL treatment.}, archive = {J_ADVS}, author = {Ruinan Jia and Yang Liu and Jilong Xiao and Yuan Xia and Xin Zhao and Huixian Ma and Jingjing Ye and Zhiyue Zhang and Tao Sun and Chunyan Ji}, doi = {10.1002/advs.202505087}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e05087}, shortjournal = {Adv. Sci.}, title = {A ROS-responsive dual-targeting drug nanocarrier serving as a GSI synergist and ferroptosis sensitizer for T-cell acute lymphoblastic leukemia}, volume = {12}, year = {2025}, }
• (2025). Ultrasound-assisted for super-rapid and high-efficient adsorption and desorption. ADVS, 12(31), e04905. (www)

  @article{ , abstract = {Adsorption–desorption technology is the basis of numerous environmental processes and industries in modern society. Undoubtedly, improving adsorption rates and renewability of sorbents can positively impact productivity. It is herein showed that poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) presented remarkable adsorption kinetics and regeneration efficiency under ultrasound. The pseudo-first-order adsorption rate constant for Rhodamine B (RhB) is 2.7753 min −1 , with an initial adsorption rate 7,000–23,000 times higher than commercial activated carbon. Meanwhile, the polymer achieves over 90% removal of the antibiotic levofloxacin (LEV) and the persistent pollutant perfluorooctanoic acid (PFOA) within 5 min. Impressively, complete desorption occurs within 2 min by simply changing the solvent, and the performance is retained across at least 20 adsorption–desorption cycles. It is proposed that, under ultrasound, the low interface tension of PVDF-HFP may accelerate solute diffusion by disrupting the liquid film, while the ferroelectric PVDF-HFP generates a built-in electric field to enhance adsorption. This research suggested an alternative strategy for developing high-performance adsorption–desorption techniques.}, archive = {J_ADVS}, author = {Yijun Han and Quanjie Lv and Linxuan Zhang and Yuruo Zhang and Xinyue Yu and Yongjie Wu and Jing Chu and Gengxin Zhang and Kang Sun and Ke Tao}, doi = {10.1002/advs.202504905}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04905}, shortjournal = {Adv. Sci.}, title = {Ultrasound-assisted for super-rapid and high-efficient adsorption and desorption}, volume = {12}, year = {2025}, }
• (2025). Exploration of oxygen reduction reaction catalyzed by FePPc and pz-FeTPr conjugated organic polymer: Insights from grand-canonical density functional theory. ADVS, 12(31), e04887. (www)

  @article{ , abstract = {This report examines the oxygen reduction reaction (ORR) catalyzed by iron-polyphthalocyanine (FePPc) and pyrazine-linked iron-coordinated tetrapyrrole (Pz-FeTPr) conjugated organic polymer (COP) catalysts, utilizing grand-canonical density functional theory (GC-DFT) and microkinetic (MK) simulations. The computed half-wave potential for AA stacking FePPc under alkaline conditions is in strong agreement with experimental findings. The ORR mechanism for AA stacking FePPc is characterized by the * O 2 mechanism ( ), with the Fe site serving as the active site. In the case of Pz-FeTPr, the ORR mechanism is similarly governed by the * O 2 mechanism, with the Fe site remaining the active site at lower potentials (less than 0.5 V RHE , vs reversible hydrogen electrode). However, at higher potentials (greater than 0.5 V RHE ), the Fe site becomes obstructed by , resulting in a shift of the active site from the Fe site to a neighboring C site (designated as type A3). The corresponding ORR mechanism at the C site is denoted as mechanism ( ). This mechanism yields a calculated half-wave potential that aligns well with experimental observations. The mechanisms identified for FePPc and Pz-FeTPr can be substantiated by the Raman signals detected in experimental studies.}, archive = {J_ADVS}, author = {Pengfei Yuan and Chong Li and Jianan Zhang and Fei Wang and Ying Zhao and Xuebo Chen}, doi = {10.1002/advs.202504887}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04887}, shortjournal = {Adv. Sci.}, title = {Exploration of oxygen reduction reaction catalyzed by FePPc and pz-FeTPr conjugated organic polymer: Insights from grand-canonical density functional theory}, volume = {12}, year = {2025}, }
• (2025). Probing anisotropic quasiparticle dynamics and topological phase transitions in quasi-1D topological insulator ZrTe5. ADVS, 12(31), e04798. (www)

  @article{ , abstract = {The transition metal pentatelluride ZrTe 5 exhibits rich lattice-sensitive topological electronic states, and demonstrates great potential in photoelectric and thermoelectric devices. However, a comprehensive investigation of electron-phonon coupling and phonon scattering process remains limited, despite their importance for transport properties and device optimization. Here, the hot carrier dynamics and a 1.15 THz A g mode coherent phonon in ZrTe 5 are investigated by femtosecond transient spectroscopy across 10–300 K. Notably, polarization-dependent measurements explicitly decouple a strong anisotropic transient response, which is attributed to the effects of excited-state electron relaxation and reflectivity modulation by displacive excited coherent phonons. The temperature dependence of electron relaxation time in ZrTe 5 shows an inflection point, first offering the ultrafast dynamical signature of a temperature-driven Lifshitz transition. At low temperatures, a long-lived electron relaxation component emerges in the transient response, providing possible evidence of topological surface states in ZrTe 5 . In addition, the temperature-dependent coherent phonon is also analyzed, revealing that its scattering is dominated by three-phonon interactions and exhibits a relatively long lifetime compared to other modes. This work deepens the understanding of ultrafast processes in ZrTe 5 , resolves longstanding questions, paves the way for studying electronic phase transitions, and advances ZrTe 5 's application in optoelectronic and quantum devices.}, archive = {J_ADVS}, author = {Yueying Hou and Linze Li and Sutao Sun and Gan Liu and Hongyuan Zhao and Zhiheng Chen and Xuejun Yan and Yang-Yang Lv and Yurong Yang and Shu-Hua Yao and Jian Zhou and Y.B. Chen and Ming-Hui Lu and Vitalyi Gusev and Yan-Feng Chen}, doi = {10.1002/advs.202504798}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04798}, shortjournal = {Adv. Sci.}, title = {Probing anisotropic quasiparticle dynamics and topological phase transitions in quasi-1D topological insulator ZrTe5}, volume = {12}, year = {2025}, }
• (2025). Chirality regulates stem cell fate and promotes corneal epithelial regeneration via manipulating notch pathway. ADVS, 12(31), e04732. (www)

  @article{ , abstract = {The differentiation and stemness maintenance of stem cells are the core topics in cell biology and regenerative medicine, involving cell fate determination, developmental regulation and tissue regeneration. Chirality is an essential factor influencing multiple biological processes, including protein interactions, stem cell development and disease pathogenesis. However, its roles in regulating stem cells fate, especially limbal epithelial stem cells (LESCs), remain elusive. Herein, it is first discovered that right-handed chiral hydrogel (DH) enhanced LESCs proliferation, migration, and differentiation into corneal epithelial cells, while left-handed chiral hydrogel (LH) can partially preserve LESCs stemness. Further in vivo experiments demonstrated that 3D DH effectively accelerated corneal wound healing process, inhibited both inflammation and vascularization in a partial limbal stem cell deficiency model. Mechanistically, DH activates Notch signaling by increasing its stereo-affinity to Notch1, facilitating Notch intracellular domain release and HES1 transcription, thereby directing LESCs fate. Collectively, this work highlights the novel role of chirality in LESCs fate determination and confirms DH as a drug-free, effective approach for corneal epithelial regeneration, offering a new direction for regenerative medicine and tissue engineering.}, archive = {J_ADVS}, author = {Shiding Li and Yu Zhao and Junzhao Chen and Beibei Wu and Nianxuan Wu and Hao Sun and Liangbo Chen and Chuanliang Feng and Yao Fu}, doi = {10.1002/advs.202504732}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04732}, shortjournal = {Adv. Sci.}, title = {Chirality regulates stem cell fate and promotes corneal epithelial regeneration via manipulating notch pathway}, volume = {12}, year = {2025}, }
• (2025). From waste to wealth: A review of eutectic molten salt method for direct regeneration of spent lithium-ion battery. ADVS, 12(31), e04609. (www)

  @article{ , abstract = {The rapid growth of electric vehicles (EVs) has significantly increased the demand for lithium (Li)-ion batteries (LIBs), bringing environmental, economic, and technical challenges. Developing recycling methods that ensure economic viability and reduce environmental impact is now critical. Traditional hydrometallurgical and pyrometallurgical routes, while established and widely applied for LIB recycling, generate substantial volumes of waste (wastewater, slag, toxic gas) and low-value chemical components, e.g., Li 2 CO 3 , Nickel (Ni)/Cobalt (Co)/Manganese (Mn) salts, limiting their sustainability. Nowadays, the eutectic molten salt method, a typical direct regeneration technology, is gaining attention, standing out for its non-destructive repair, cost-effectiveness, and environmental benefits. It allows flexible salt combinations, adjustable lithiation, and annealing temperatures, and the use of additives to meet specific recycling needs, improving the electrochemical performance of spent cathode materials. This review begins with an overview of LIB composition and degradation mechanisms, then delves into recent advances in the eutectic molten salt method, covering pre-treatment, salt selection, thermal optimization, and cost-benefit analysis. In addition, these eutectic molten salt methods are compared with traditional hydrometallurgical and pyrometallurgical methods in terms of both economic and environmental impacts. Finally, the considerable industrial potential of eutectic molten salt methods for LIB recycling is highlighted, especially today when the EV sector is booming.}, archive = {J_ADVS}, author = {Junyi Wang and Zehua Qi and Qi Zhao and Kaimin Shih}, doi = {10.1002/advs.202504609}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04609}, shortjournal = {Adv. Sci.}, title = {From waste to wealth: A review of eutectic molten salt method for direct regeneration of spent lithium-ion battery}, volume = {12}, year = {2025}, }
• (2025). In situ electrically resettable field-effect transistor biosensors for continuous and multiplexed neurotransmitter detection. ADVS, 12(31), e04497. (www)

  @article{ , abstract = {Accurate, real-time detection of neurotransmitters is crucial for elucidating the mechanisms of brain function and tracking the progression of neurological diseases. Biosensors usually face poor reusability induced by difficulties in probe-target separation, hindering their application for continuous monitoring. In this work, a semiconducting carbon nanotube (CNT) film field-effect transistor (FET) biosensor is developed using pH-sensitive aptamers as probes to capture targets. Through tuning the potential of on-chip palladium electrodes, the biosensor facilitates in situ pH modulation and recovery of the sensor interface, which enables an electrically resettable biosensor. The fabricated sensor demonstrates exceptional sensitivity (with femtomolar-level detection limits), high selectivity (specific responses are 20 times stronger than non-specific ones), and excellent reusability (over ten reuse cycles). Furthermore, in vitro detection demonstrates that the biosensor arrays, incorporating regional modifications and pH-sensitive probes, enable the simultaneous detection of several neurotransmitters, including dopamine, serotonin, histamine, and glutamate in complex biological samples. The combination of microfluidic techniques further lowers non-specific adsorption and cross-reactivity, ensuring reliable, repeatable real-time detection. The resettable CNT FET biosensor array holds significant promise for advancing the monitoring of neurotransmitter dynamics, serving as a powerful tool for the early diagnosis and management of neurological disorders.}, archive = {J_ADVS}, author = {Bo Xiao and Tingxian Li and Xianmao Cao and Yang Zhang and Jianping He and Mengmeng Xiao and Zhiyong Zhang}, doi = {10.1002/advs.202504497}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04497}, shortjournal = {Adv. Sci.}, title = {In situ electrically resettable field-effect transistor biosensors for continuous and multiplexed neurotransmitter detection}, volume = {12}, year = {2025}, }
• (2025). Engineering liquid hierarchical materials with DNA-programmed spherical nucleic acids. ADVS, 12(31), e04471. (www)

  @article{ , abstract = {Inspired by nature, the orchestration of self-assembling building blocks into hierarchical superstructures offers a transformative approach to functional materials design. While significant advances have been made in engineering solid-state hierarchical materials such as crystals and superlattices, creating dynamic, liquid-like hierarchical materials remains a profound challenge. Herein, a universal and efficient method is introduced to construct spherical nucleic acids (SNAs) functionalized with diverse nucleic acids (NAs), including random DNA sequences, circular DNA (circ-DNA), single guide RNA (sgRNA), messenger RNA (mRNA), and multi-branched DNA independent of sequence, length, or topology. By examining spatial configuration and mechanical rigidity in DNA-mediated bonding, precise hierarchical assembly of SNAs is enabled. Furthermore, using these multivalent SNAs as programmable molecule equivalents, liquid-phase hierarchical materials via phase separation are successfully created, forming microscale SNA droplets. These metal condensates exhibit dynamic liquid-like properties and stimuli-responsiveness, including enhanced photothermal effects in living cells. Our findings provide fundamental insights into the formation and dynamics of liquid hierarchical materials, offering potentials for designing living-matter-inspired systems and advancing applications in biomedicine and responsive materials.}, archive = {J_ADVS}, author = {Zeyu Chen and Xu Chen and Dan Lu and Huating Kong and Jingyi Ye and Chunhai Fan and Honglu Zhang and Huan Zhang}, doi = {10.1002/advs.202504471}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04471}, shortjournal = {Adv. Sci.}, title = {Engineering liquid hierarchical materials with DNA-programmed spherical nucleic acids}, volume = {12}, year = {2025}, }
• (2025). Neutrophil–Endothelium interaction mediated by S100A9 promotes pulmonary vascular remodeling during pulmonary hypertension. ADVS, 12(31), e04397. (www)

  @article{ , abstract = {Pulmonary hypertension (PH) is a severe disease characterized by pulmonary vascular remodeling in which various immune cells play a critical role in vascular remodeling, although the details are still vague. Furthermore, current clinical treatments primarily focus on pulmonary vasodilation, but do not fundamentally address vascular remodeling itself. Here, first significant changes in neutrophils during the development of PH are demonstrated and show that neutrophil depletion can effectively attenuate disease progression. Moreover, the data show that neutrophil-derived S100A9 is the key mediator to promote vascular remodeling, while both knockout and inhibition of S100A9 can prevent PH. In a co-culture system of neutrophils and endothelial cells (ECs), hypoxic stimulation leads to increased S100A9 secretion by neutrophils, which activates the RAGE/PI3K/AKT pathway and causes dysfunction of ECs. These findings suggest that neutrophil-derived S100A9 mediated neutrophil-EC crosstalk plays an important role in pulmonary vascular remodeling, providing a promising strategy for treatment of PH.}, archive = {J_ADVS}, author = {Yu Guo and Zhenqiang Gao and Ruoyang Zhang and Huanyu Long and Muzhi Zhang and Lin Liu and Zhe An and Yuezhe Shi and Ye Cui and Yufeng Jia and Lei Wang and Ying Sun and Jie Liu and Wei Wang}, doi = {10.1002/advs.202504397}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04397}, shortjournal = {Adv. Sci.}, title = {Neutrophil–Endothelium interaction mediated by S100A9 promotes pulmonary vascular remodeling during pulmonary hypertension}, volume = {12}, year = {2025}, }
• (2025). Fibronectin fibers progressively lose their tension in invasive human breast carcinoma while being tensed in DCIS and healthy breast tissue. ADVS, 12(31), e04351. (www)

  @article{ , abstract = {Extracellular matrix (ECM) remodeling plays critical roles in cancer progression and involves alterations in its composition and biophysical properties. Aggressiveness and malignancy of solid tumors are strongly correlated with tissue stiffening, mainly due to upregulated ECM production and cross-linking. However, nothing is known about the tensional alterations that occur at the single-fiber level during tumorigenesis in humans. The well-validated peptide tension probe (FnBPA5) now reveals that Fibronectin fibers lose their tension as invasive tumors progress while they are stretched in healthy human breast tissue stroma and in ductal carcinoma in situ (DCIS), the non-invasive precursor of breast cancer. In invasive carcinomas, cancer cells, cancer-associated fibroblasts (CAFs) and infiltrating immune cells (cytotoxic T cells and regulatory T cells), are predominantly located in proximity to untensed Fibronectin fibers. This is significant, as Fibronectin fiber stretching can mechano-regulate the reciprocal cell-ECM crosstalk and the bioavailability of ECM-bound molecules. Not only tissue stiffening, but also the accumulation of untensed Fibronectin fibers may serve as a mechanical biomarker that correlates with tumor grade. Loss of Fibronectin fiber tension may play a central role in regulating tumor invasiveness. This suggests that physically altered ECM fibers can be exploited for stroma-targeted drug delivery and immunotherapy.}, archive = {J_ADVS}, author = {Arnaud Miéville and Charlotte M. Fonta and Cornelia Leo and Lucine Christe and Jörg Goldhahn and Gad Singer and Viola Vogel}, doi = {10.1002/advs.202404351}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04351}, shortjournal = {Adv. Sci.}, title = {Fibronectin fibers progressively lose their tension in invasive human breast carcinoma while being tensed in DCIS and healthy breast tissue}, volume = {12}, year = {2025}, }
• (2025). Tailoring hydrogenation to enhance defect suppression and charge transport in hydrogenated amorphous silicon for flexible photodetectors. ADVS, 12(31), e04199. (www)

  @article{ , abstract = {Visible-light photodetectors (VPDs) garner significant attention due to their diverse applications in optical communication. However, conventional VPDs struggle to achieve both transparency and flexibility, limiting their use in emerging technologies. Hydrogenated amorphous silicon (a-Si:H) offers a promising platform for flexible optoelectronics for compatibility with substrates, although temperature reduction causes degradation of electrical and optical properties due to insufficient hydrogen passivation. In this study, the effect of the hydrogen-to-silane (H 2 /SiH 4 ; f ratio) gas is systematically investigated ratio on the microstructural, optical, and electrical properties of a-Si:H films synthesized at an ultra-low temperature of 90 °C using plasma-enhanced chemical vapor deposition (PECVD). Raman and Fourier-transform infrared (FT-IR) spectroscopy reveal that an optimized H 2 /SiH 4 ratio minimizes Si─H 2 bonding, effectively reducing defect density and improving film stability. Spectroscopic ellipsometry confirms that this ratio optimizes the refractive index and optical bandgap, enhancing light absorption. Electrical measurements demonstrate that photodiodes with the optimized a-Si:H layer exhibit superior photosensitivity and suppressed dark current ( f 2 : 20.6 and f 8 : 2.70 × 10 −10 A, respectively), attributed to improved carrier transport and reduced Shockley–Read–Hall (SRH) recombination. Furthermore, flexible photodetectors maintain high mechanical reliability under repeated bending cycles. These findings highlight the potential of ultra-low-temperature PECVD a-Si:H films for high-performance, flexible photodetectors.}, archive = {J_ADVS}, author = {Ye-ji Jeong and Kyeong-jin Hyun and Hee-Won Jang and Jongwon Yoon and Yonghun Kim and Woon Ik Park and Soo-Won Choi and Jung-Dae Kwon}, doi = {10.1002/advs.202504199}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04199}, shortjournal = {Adv. Sci.}, title = {Tailoring hydrogenation to enhance defect suppression and charge transport in hydrogenated amorphous silicon for flexible photodetectors}, volume = {12}, year = {2025}, }
• (2025). Antagonistic ghd7-OsNAC42 complexes modulate carbon and nitrogen metabolism to achieves superior quality and high yield in rice. ADVS, 12(31), e04163. (www)

  @article{ , abstract = {Close coordination of carbon and nitrogen (C/N) metabolism is necessary to maintain optimal growth and development of plants and other cellular organisms. The central regulator for achieving high-yield and quality synergy in rice through regulating the dynamic C/N balance has seldom been reported. Here, the novel function of Grain number, plant height, and heading date7 (Ghd7) gene are reported as both a negative regulator of grain protein content and a positive regulator of rice grain quality (including appearance quality and eating quality). As a transcription factor with both activating and inhibitory functions, Ghd7 directly binds to CCACC motif genes involved in C/N metabolism. OsNAC42, an interacting protein of Ghd7, antagonistically regulates the expression of these target genes in rice seedlings and endosperm by forming a heterodimer with Ghd7. The antagonistic Ghd7-OsNAC42 module can flexibly regulate C/N metabolism in vivo in response to various nitrogen levels, thereby maintaining a dynamic C/N balance. Phenotypically, OsNAC42 enhances grain protein content but compromises quality-functions opposing Ghd7's effects. In summary, the discovery of the Ghd7-OsNAC42 antagonistic module provides new insights into the synergy between superior quality and high yield in rice.}, archive = {J_ADVS}, author = {Guangming Lou and Pingli Chen and Pingbo Li and Haozhou Gao and Jiawang Xiong and Shanshan Wan and Yuanyuan Zheng and Yufu Wang and Mufid Alam and Yingnanjun Chen and Lei Wang and Jingjing Bai and Xuan Tan and Wenting Rao and Bian Wu and Hao Zhou and Yanhua Li and Guanjun Gao and Qinglu Zhang and Jinghua Xiao and Xianghua Li and Xuelei lai and Qifa Zhang and Yuqing He}, doi = {10.1002/advs.202504163}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04163}, shortjournal = {Adv. Sci.}, title = {Antagonistic ghd7-OsNAC42 complexes modulate carbon and nitrogen metabolism to achieves superior quality and high yield in rice}, volume = {12}, year = {2025}, }
• (2025). Advancing soil organic carbon prediction: A comprehensive review of technologies, AI, process-based and hybrid modelling approaches. ADVS, 12(31), e04152. (www)

  @article{ , abstract = {Measurement, monitoring, and prediction of soil organic carbon (SOC) are fundamental to supporting climate change mitigation efforts and promoting sustainable agricultural management practices. This review discusses recent advances in methodologies and technologies for SOC quantification, including remote sensing (RS), proximal soil sensing (PSS), artificial intelligence (AI) for SOC modelling (in particular, machine learning (ML) and deep learning (DL)), biogeochemical modelling, and data fusion. Integrating data from RS, PSS, and other sensors usually leads to good SOC predictions, provided it is supported by careful calibration, validation across diverse pedo-climatic and land management, and the use of data processing and modelling frameworks. We also found that the accuracy of AI-driven SOC prediction improves when RS covariates are included. Although DL often outperforms classical ML, there is no single best AI algorithm. By incorporating simulated outputs from biogeochemical model as additional training data for AI, causal relationships in SOC turnover can be incorporated into empirical modelling, while maintaining predictive accuracy. In conclusion, SOC prediction can be enhanced through 1) integrating sensing technologies, 2) applying AI, notably DL, 3) addressing biogeochemical model limitations (assumptions, parameterization, structure), 4) expanding SOC data availability, 5) improving mathematical representation of microbial influences on SOC, and 6) strengthening interdisciplinary cooperation between soil scientists and model developers.}, archive = {J_ADVS}, author = {Zijuan Ding and Ke Liu and Sabine Grunwald and Pete Smith and Philippe Ciais and Bin Wang and Alexandre M.J.-C. Wadoux and Carla Ferreira and Senani Karunaratne and Narasinha Shurpali and Xiaogang Yin and Dale Roberts and Oli Madgett and Sam Duncan and Meixue Zhou and Zhangyong Liu and Matthew Tom Harrison}, doi = {10.1002/advs.202504152}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04152}, shortjournal = {Adv. Sci.}, title = {Advancing soil organic carbon prediction: A comprehensive review of technologies, AI, process-based and hybrid modelling approaches}, volume = {12}, year = {2025}, }
• (2025). An off-the-shelf artificial blood clot hydrogel neutralizing multiple proinflammatory mediators for pro-regenerative periodontitis treatment. ADVS, 12(31), e04106. (www)

  @article{ , abstract = {Periodontitis is a destructive and chronic inflammatory disease initiated and sustained by multiple proinflammatory mediators. Current therapies mainly deal with bacteria elimination, but directly addressing the over-accumulated multiple inflammatory mediators in the periodontal microenvironment still remains a substantial challenge for regenerative periodontitis treatment. Herein, inspired by blood coagulation, an off-the-shelf artificial blood clot hydrogel encapsulated with platelet-rich plasma (PRP) is reported to mitigate the deteriorative inflammatory environment in periodontitis. The hydrogel (CCS-RSF@PRP) with a hierarchical fibers-interwoven network structure, in which the activated platelets are enriched, is structurally similar to the native blood clot. Functionally, in addition to the function of enriching and releasing growth factors, CCS-RSF@PRP can remarkably scavenge reactive oxygen species (ROS), neutralize endotoxin lipopolysaccharide (LPS), and proinflammatory cytokines (TNF-α, IFN-γ and IL-1β), inhibit M1 macrophage polarization and induce M2 macrophage polarization, thus blocking the chronic inflammatory feedback loop in the periodontitis. In rat periodontitis model, CCS-RSF@PRP hydrogel significantly expedits the repair of periodontium by normalizing the periodontal immune-environment. The work highlights the importance of local immunomodulation in the treatment of periodontitis, and the engineered PRP-derived hydrogel can mimic and expand the structure and function of native blood clot, holding great promise in treating chronic inflammatory diseases.}, archive = {J_ADVS}, author = {Yini Huangfu and Zhezhe Zhao and Xiang Liu and Jingrong Wang and Yufeng Zhang and Tingting Lan and Yonglan Wang and Chenxuan Wu and Ju Zhang and Pingsheng Huang and Chuangnian Zhang and Anjie Dong and Zujian Feng and Deling Kong and Weiwei Wang}, doi = {10.1002/advs.202504106}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e04106}, shortjournal = {Adv. Sci.}, title = {An off-the-shelf artificial blood clot hydrogel neutralizing multiple proinflammatory mediators for pro-regenerative periodontitis treatment}, volume = {12}, year = {2025}, }
• (2025). Unraveling tissue-specific fatty acid biosynthesis and inter-tissue crosstalk in mice through stable-isotope tracing metabolomics. ADVS, 12(31), e03662. (www)

  @article{ , abstract = {Biosynthesis of free fatty acids (FFAs) in mammals is pivotal for metabolic homeostasis, yet a comprehensive understanding of tissue-specific biosynthesis and inter-tissue crosstalk of FFAs remains incomplete. In vivo stable-isotope tracing metabolomics is utilized to comprehensively measure FFA biosynthesis and inter-tissue crosstalk in mice. Systematically assessing tissue-specific biosynthesis of 13 FFAs across 15 tissues unveils dynamic spatial and temporal accumulation and redistribution of FFAs throughout the body. Employing an analytical framework to deconvolve mass isotopologue patterns, inter-tissue crosstalk is explored for saturated, polyunsaturated, and monounsaturated FFAs, and quantify communications of FFA (16:0) and FFA (18:0) between the liver and other tissues. Then, a decline in fatty acid biosynthesis in peripheral tissues but not in the brain of aged mice is observed, particularly evident in palmitic acid and monounsaturated fatty acids. These findings illuminate the complex interplay between tissue-specific fatty acid biosynthesis and the maintenance of metabolic homeostasis.}, archive = {J_ADVS}, author = {Beizi Xing and Ruohong Wang and Tianzhang Kou and Wenbin Liu and Zheng-Jiang Zhu}, doi = {10.1002/advs.202503662}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e03662}, shortjournal = {Adv. Sci.}, title = {Unraveling tissue-specific fatty acid biosynthesis and inter-tissue crosstalk in mice through stable-isotope tracing metabolomics}, volume = {12}, year = {2025}, }
• (2025). SUMOylation is a translatable target in hypoxic MNPs regulating retinal vasculopathy. ADVS, 12(31), e03505. (www)

  @article{ , abstract = {Retinal vasculopathies pose a devastating threat to human health. While anti-VEGF therapy situates the first-line treatment for patients, the clinical efficacy is limited by suboptimal response and potential risks raised by long-term high-dosage use. Neurovascular unit uncoupling is recognized as a key mechanism contributing to pathological neovascularization, yet how immune components get involved is less appreciated. Here, it is reported that SUMOylation modulates the pro-angiogenic capacity of macrophage, and inhibition of the SUMO-conjugating enzyme UBC9 synergizes with anti-VEGF therapy in preclinical models. Diabetic human retinal mononuclear phagocytes (MNPs) overexpress UBC9. Genetic ablation of UBC9 in MNPs compromises the crosstalk with endothelial cells by reducing Vegfa splicing isoforms, including Vegf120 , Vegf144 , Vegf164 , and Vegf188 . Mechanistically, hypoxia facilitates the SUMOylation of fused in sarcoma (FUS) protein at lysine residues K327 and K502. Mutation of the SUMOylation sites enhances FUS binding to the Vegfa 3′-untranslated region (3′UTR), leading to mRNA destabilization and decreased VEGFA production. Intravitreal administration of anti-VEGF elevates UBC9 whereas Ubc9 siRNA-liposomes alleviates retinal vascular leakage and choroidal neovascularization, and a better therapeutic efficacy is yielded when combining with anti-VEGF therapy. Taken together, this study highlights a novel approach for treating retinal vascular diseases by modulating the MNPs-endothelial cell interplay.}, archive = {J_ADVS}, author = {Zheng Zhong and Guangyu Liang and Huimin Yu and Jiaqi Li and Ruohong Wang and Xiaohong Ma and Ziqing Zhou and Yin Zhao and Fei Sun and Xufang Sun}, doi = {10.1002/advs.202503505}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e03505}, shortjournal = {Adv. Sci.}, title = {SUMOylation is a translatable target in hypoxic MNPs regulating retinal vasculopathy}, volume = {12}, year = {2025}, }
• (2025). Targeted intervention strategies for Maternal–Offspring transmission of christensenellaceae in pigs via a deep learning model. ADVS, 12(31), e03411. (www)

  @article{ , abstract = {Understanding the mechanisms of maternal microbial transmission is crucial for early gut microbiota development and long-term health outcomes in offspring. However, early maternal microbial interventions remain a challenge due to the complexity of accurately identifying transmitted taxa. Here, the maternal–offspring microbial transmission model (MOMTM), a deep learning framework specifically designed to map maternal microbiota transmission dynamics across pig breeds and developmental stages, is introduced. Using MOMTM, key transmitted taxa, such as the Christensenellaceae R-7 are successfully predicted, which show high transmission centrality during early development periods. Additionally, it is demonstrated that galacto-oligosaccharide intervention in sows promotes a Christensenellaceae R-7 -dominated enterotype and improves fiber digestibility in offspring. Further analysis reveals that Christensenellaceae , particularly Christensenella minuta , have enhanced adhesion and mucin utilization capabilities, facilitating its gut colonization. These findings highlight MOMTM's potential as a novel approach for microbiota-targeted health interventions in early life, offering insights into strategies that promote gut health and development from birth.}, archive = {J_ADVS}, author = {Haibo Shen and Xiaokang Ma and Longlin Zhang and Hao Li and Jichang Zheng and Shengru Wu and Ke Zuo and Yulong Yin and Jing Wang and Bie Tan}, doi = {10.1002/advs.202503411}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e03411}, shortjournal = {Adv. Sci.}, title = {Targeted intervention strategies for Maternal–Offspring transmission of christensenellaceae in pigs via a deep learning model}, volume = {12}, year = {2025}, }
• (2025). Structural variations associated with adaptation and coat color in qinghai-tibetan plateau cattle. ADVS, 12(31), e03258. (www)

  @article{ , abstract = {Structural variations (SVs) play crucial roles in the evolutionary adaptation of domesticated animals to natural and human-controlled environments, but SVs have not been explored in Tibetan cattle, which recently migrated and rapidly adapted to the high altitudes of the Qinghai-Tibetan Plateau (QTP). In this study, a de novo chromosome-level genome assembly for Tibetan cattle is constructed. It is found that using a lineage-specific reference genome significantly increased variant detection accuracy and completeness. Analysis of long-read sequencing data from 36 high-altitude QTP and 48 low-altitude cattle identified 222 528 SVs and 259 SV hotspot regions. Positively selected SVs in high-altitude cattle are related to energy metabolism erythropoiesis and angiogenesis, and peroxisomal metabolism. A 102-bp intronic deletion in GNPAT likely upregulated its expression. It is distinguished 7293 SVs that may be introgressed from yak, including variants upstream of the hypoxia-inducing gene EGLN1 . Finally, a ≈2-Mb heterozygous inversion and two translocations on chromosome 6 are likely associated with the cattle gray coat via regulatory effects on the KIT gene. The results confirm the importance of SVs in evolutionary adaptation and the contribution yak-introgressed SVs to the rapid acclimatization of QTP cattle.}, archive = {J_ADVS}, author = {Xiaoting Xia and Fuwen Wang and Xiaoyu Luo and Shuang Li and Yang Lyu and Yining Zheng and Zhijie Ma and Kaixing Qu and Rende Song and Jianyong Liu and Jicai Zhang and Basang Wangdui and Basang Zhuzha and Suolang Quji and Li Zhao and Silang Wangmu and Ciren Luobu and Nima Cangjue and Danzeng Luosang and Suolang Sizhu and Haijian Cheng and Ruizhe Li and Zhipeng Wu and Ruihua Dang and Yongzhen Huang and Xianyong Lan and Luohao Xu and Haifei Hu and WaiYee Low and Zhuqing Zheng and Yu Wang and Yuanpeng Gao and Lu Deng and Johannes A. Lenstra and Jianlin Han and Xueyi Yang and Wenfa Lyu and Bizhi Huang and Chuzhao Lei and Ningbo Chen}, doi = {10.1002/advs.202503258}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e03258}, shortjournal = {Adv. Sci.}, title = {Structural variations associated with adaptation and coat color in qinghai-tibetan plateau cattle}, volume = {12}, year = {2025}, }
• (2025). Bidirectional interaction between the brain and bone in traumatic brain injury. ADVS, 12(31), e03149. (www)

  @article{ , abstract = {Traumatic brain injury (TBI), which refers to damage caused by external forces to the brain, significantly affects systemic organs and tissues, especially bone homeostasis. An increasing number of studies have revealed bidirectional crosstalk between the brain and bone, and the interactions between these systems in the context of TBI remain unclear. Here, existing research on the relationship between the brain and bone is summarized to explore their interactions and underlying mechanisms in TBI. Clinical studies indicate that long-term loss of bone mass and increased risk of osteoporosis occur in patients after TBI. Interestingly, the rate of bone healing is accelerated when patients with TBI also suffer from fractures, which then worsens the prognosis of TBI. The bidirectional effects and underlying mechanisms that connect TBI and bone through neurohormones, neuropeptides, neurotransmitters, and mechanical factors are reviewed. The promising applications of bone marrow mesenchymal stromal cells, their derived extracellular vesicles, and bone-derived factors for TBI recovery are also elucidated. Strategies to prevent osteoporosis management and potential mechanisms to accelerate fracture healing after TBI are proposed based on the brain–bone axis, and results are expected to translate into a clinical scenario for TBI and bone disease.}, archive = {J_ADVS}, author = {Wei Zhang and Jun Zou and Lingli Zhang}, doi = {10.1002/advs.202503149}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e03149}, shortjournal = {Adv. Sci.}, title = {Bidirectional interaction between the brain and bone in traumatic brain injury}, volume = {12}, year = {2025}, }
• (2025). Loss of STARD7 triggers metabolic reprogramming and cell cycle arrest in breast cancer. ADVS, 12(31), e03022. (www)

  @article{ , abstract = {Cancer cells adapt their metabolism to support aberrant cell proliferation. However, the functional link between metabolic reprogramming and cell cycle progression remains largely unexplored. Mitochondria rely on the transfer of multiple lipids from the endoplasmic reticulum (ER) to their membranes to be functional. Several mitochondrial-derived metabolites influence cancer cell proliferation by modulating the epigenome. Here, the loss of STARD7, a lipid transfer protein whose expression is enhanced in breast cancer, is shown to lead a metabolic reprogramming characterized by the accumulation of carnitine derivatives and S-Adenosyl-L-methionine (SAM). Elevated SAM levels cause the increase of H3K27 trimethylation on many gene promoters coding for candidates involved in cell cycle progression. Likewise, STARD7 deficiency triggers cell cycle arrest and impairs ERα-dependent cell proliferation. Moreover, EGFR signaling is also impaired in triple negative breast cancer cells lacking STARD7, at least due to deregulated EGFR trafficking to lysosomes. Therefore, mitochondria rely on STARD7 to support cell cycle progression in breast cancer.}, archive = {J_ADVS}, author = {Ewelina Dondajewska and Paula Allepuz-Fuster and Chloé Maurizy and Alexandre Hego and Sandra Ormenese and Quentin Lion and Arnaud Blomme and Pierre Close and Arnaud Lavergne and Latifa Karim and Marc Thiry and Ivan Nemazanyy and Roopesh Krishnankutty and Jair Marques and Alex von Kriegsheim and Nathaniel F. Henneman and Ganna Panasyuk and Kateryna Shostak and Alain Chariot}, doi = {10.1002/advs.202503022}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e03022}, shortjournal = {Adv. Sci.}, title = {Loss of STARD7 triggers metabolic reprogramming and cell cycle arrest in breast cancer}, volume = {12}, year = {2025}, }
• (2025). NAT10 increases lysosomal acidification to promote esophageal cancer metastasis via ac4C acetylation of ATP6V0E1 mRNA. ADVS, 12(31), e02931. (www)

  @article{ , abstract = {N-acetyltransferase 10 (NAT10)-catalyzed N4-acetylcytidine (ac4C) modification has been reported to drive tumor metastasis. Lysosomal dysregulation plays an important role in human diseases, but its function in esophageal cancer metastasis is unclear. It remains unknown whether NAT10 regulates lysosomal function, and the underlying mechanism and treatment strategy warrants investigation. Here, a novel role of NAT10 in inducing lysosomal acidification is revealed, and the clinical and biological significance of ATP6V0E1 in tumor metastasis is uncovered. Mechanistically, NAT10 promotes the translation efficiency of ATPase H + transporting V0 subunit e1 (ATP6V0E1) mRNA in an ac4C-dependent manner to facilitate ATP6V0E1 expression and vacuolar H + -ATPase (v-ATPase) activity, enhancing the lysosomal degradation of E-cadherin, ultimately accelerating tumor metastasis. Furthermore, G-749 is screened and identified as a novel NAT10 inhibitor capable of effectively impeding lysosomal acidification and tumor metastasis by disrupting the NAT10-Ubiquitin-specific Peptidase 39 (USP39) interaction. Overall, the results unveil a novel role of ac4C modifications in regulating lysosomal acidification and propose a potential strategy by targeting NAT10 to inhibit esophageal cancer metastasis.}, archive = {J_ADVS}, author = {Yu-Juan Zhan and Chun-Miao Deng and Lin Tang and Shu-Jun Li and Tao-Yang Xu and Xian Wei and Xin-Yi Zhang and Can-Can Zheng and Li Deng and Cui Shao and Zhong-Min Ouyang and Alfred King-Yin Lam and Rong Zhang and Jun Liu and Xing-Yuan Shi and Zhen-Yu Pan and Wei Dai and Ming-Liang He and Simon Law and Xu Li and Xiao-Bing Chen and Cheng Zhou and Bin Li and Wen-Wen Xu}, doi = {10.1002/advs.202502931}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02931}, shortjournal = {Adv. Sci.}, title = {NAT10 increases lysosomal acidification to promote esophageal cancer metastasis via ac4C acetylation of ATP6V0E1 mRNA}, volume = {12}, year = {2025}, }
• (2025). An explainable multimodal artificial intelligence model integrating histopathological microenvironment and EHR phenotypes for germline genetic testing in breast cancer. ADVS, 12(31), e02833. (www)

  @article{ , abstract = {Genetic testing for pathogenic germline variants is critical for the personalized management of high-risk breast cancers, guiding targeted therapies and cascade testing for at-risk families. In this study, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing) is proposed, a deep learning framework that integrates histopathological microenvironment features from whole-slide images with clinical phenotypes from electronic health records for precise prescreening of germline BRCA1/2 mutations. Leveraging a multi-scale Transformer-based deep generative architecture, MAIGGT employs a cross-modal latent representation unification mechanism to capture complementary biological insights from multimodal data. MAIGGT is rigorously validated across three independent cohorts and demonstrated robust performance with areas under receiver operating characteristic curves of 0.925 (95% CI 0.868 – 0.982), 0.845 (95% CI 0.779 – 0.911), and 0.833 (0.788 – 0.878), outperforming single-modality models. Mechanistic interpretability analyses revealed that BRCA1/2 -mutated associated tumors may exhibit distinct microenvironment patterns, including increased inflammatory cell infiltration, stromal proliferation and necrosis, and nuclear heterogeneity. By bridging digital pathology with clinical phenotypes, MAIGGT establishes a new paradigm for cost-effective, scalable, and biologically interpretable prescreening of hereditary breast cancer, with the potential to significantly improve the accessibility of genetic testing in routine clinical practice.}, archive = {J_ADVS}, author = {Zijian Yang and Changyuan Guo and Jiayi Li and Yalun Li and Lei Zhong and Pengming Pu and Tongxuan Shang and Lin Cong and Yongxin Zhou and Guangdong Qiao and Ziqi Jia and Hengyi Xu and Heng Cao and Yansong Huang and Tianyi Liu and Jian Liang and Jiang Wu and Dongxu Ma and Yuchen Liu and Ruijie Zhou and Xiang Wang and Jianming Ying and Meng Zhou and Jiaqi Liu}, doi = {10.1002/advs.202502833}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02833}, shortjournal = {Adv. Sci.}, title = {An explainable multimodal artificial intelligence model integrating histopathological microenvironment and EHR phenotypes for germline genetic testing in breast cancer}, volume = {12}, year = {2025}, }
• (2025). Glucose-responsive and analgesic gel for diabetic subcutaneous abscess treatment by simultaneously boosting photodynamic therapy and relieving hypoxia. ADVS, 12(31), e02830. (www)

  @article{ , abstract = {The treatment of diabetic abscess remains highly challenging due to the complex wound healing environment, which includes bacterial infection, hypoxia, and pain, severely compromising patients' quality of life. Developing effective treatment strategies to address these multifaceted issues continues to pose significant challenges. In this study, a glucose-triggered gel with self-producing oxygen, photodynamic behavior, and analgesic properties is employed to address the aforementioned problems. The gel utilizes the cascade reaction of glucose oxidase and catalase to convert the excessive glucose in diabetic abscess tissue into oxygen, alleviate the hypoxia in the infected tissue, and ensure the occurrence of hypoxia photodynamic behavior to generate sufficient reactive oxygen species (ROS) to combat pathogenic bacteria. Simultaneously, borneol within the gel can not only enhance the sensitivity of bacteria to ROS by regulating the oxidative stress system but also augment the antibacterial effect of ROS. Moreover, borneol can serve as an analgesic to alleviate pain in patients. In vivo experiments have demonstrated that the combination of photodynamic and borneol therapy can eliminate the bacteria at the abscess site and enable the abscess to heal completely within 12 days. Therefore, this study established a glucose-responsive gel for a combined therapy strategy of hypoxic improvement photodynamic therapy and borneol to facilitate wound healing in diabetic abscesses.}, archive = {J_ADVS}, author = {Bin Huang and Honglin An and Jianfeng Chu and Shiqi Ke and Jing Ke and Yiman Qiu and Jieping Zhang and Hanqi Zhu and Jiahui Lin and Minguang Yang and Dongliang Yang and Xuejiao Song and Weilin Liu}, doi = {10.1002/advs.202502830}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02830}, shortjournal = {Adv. Sci.}, title = {Glucose-responsive and analgesic gel for diabetic subcutaneous abscess treatment by simultaneously boosting photodynamic therapy and relieving hypoxia}, volume = {12}, year = {2025}, }
• (2025). Water-catalytic deconstructive and proton transfer cyclopropanation of sulfoxonium ylide with olefin. ADVS, 12(31), e02430. (www)

  @article{ , abstract = {Cyclopropane rings, with their distinct structure and reactivity, have long been a focus in organic chemistry and are significant pharmacophores in medicinal chemistry. Conventional direct cyclopropanation methods for olefins do not modify the functional groups on the α - or β -carbon of olefins. Herein, a novel deconstructive cyclopropanation reaction is designed for olefins using a close–open–close ring strategy. This enables the migration of functional groups to the α - or β -carbon of olefins, leading to the formation of regioselective cyclopropane compounds, which is a previously unreported approach. By exploiting the zwitterionic property of sulfoxonium ylides and combining them with Density Functional Theory (DFT) computations, the reaction is proposed to proceed via a [2 + 2] cycloaddition to form a strained cyclobutene intermediate, followed by cyclobutane ring-opening and nucleophilic substitution through a water-involved proton-shuttle process for ring closure. Hydrogen-bonding interactions play a significant role in controlling the regioselectivity.}, archive = {J_ADVS}, author = {Xianglin Yu and Liuting Huang and Haiyue Yang and Lijuan Song and Yi Jin}, doi = {10.1002/advs.202502430}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02430}, shortjournal = {Adv. Sci.}, title = {Water-catalytic deconstructive and proton transfer cyclopropanation of sulfoxonium ylide with olefin}, volume = {12}, year = {2025}, }
• (2025). Gasdermin D-mediated pyroptosis exerts two opposite effects of resisting enzymatic digestion and expanding inflammatory response in acute pancreatitis. ADVS, 12(31), e02412. (www)

  @article{ , abstract = {Gasdermin D (GSDMD)-induced pyroptosis is associated with inflammatory disease. However, the role of GSDMD in acute pancreatitis (AP) is not yet fully elucidated. This study reveals that GSDMD serves two distinct functions in pancreatic acinar cells and macrophages. In acinar cells, GSDMD inhibits the synthesis of pancreatic enzyme by downregulating the expression of Prss1, Pnlip, and Amy1 via the inhibition of the protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/ribosomal protein S6 (RPS6)/eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) pathway. Moreover, GSDMD induces pancreatic acinar cells to express mucin 1 (MUC1) by activating the nuclear factor kappa-B (NF-κB) pathway, which forms a barrier that prevents digestive enzyme-mediated digestion. However, GSDMD promotes the secretion of inflammatory cytokines by macrophages during AP. In addition, GSDMD increases the infiltration of macrophages and neutrophils in AP and increases the proportion of Th1 and Th17 lymphocyte subsets in peripheral blood. However, in general, the harmful effect of GSDMD in AP outweighs its beneficial effect, and GSDMD knockout can effectively alleviate AP. These findings indicate that GSDMD may be a potential target for the treatment of AP; however, its dual effects need to be comprehensively considered.}, archive = {J_ADVS}, author = {Chaoxu Liu and Ning Liang and Chen Wu and Zhaoyan Qiu and Qian Huang and Xiaolong Wei and Shurong Zhang and Shuanghong Lei and Tao Yang and Gang Wang and Qian Wang}, doi = {10.1002/advs.202502412}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02412}, shortjournal = {Adv. Sci.}, title = {Gasdermin D-mediated pyroptosis exerts two opposite effects of resisting enzymatic digestion and expanding inflammatory response in acute pancreatitis}, volume = {12}, year = {2025}, }
• (2025). Anomalous glassy thermal conductivity in a perovskite bismuthate induced by structural dynamic instability. ADVS, 12(31), e02379. (www)

  @article{ , abstract = {Unraveling the underlying mechanisms at the origin of ultra-low thermal conductivity in pristine crystals is of central relevance to designing new functional materials. Here, a study of thermal conductivity κ( T ) in an extended temperature range (1.5–400 K) is reported in the single-crystalline bismuthate perovskite BaBiO 3 . The measured κ( T ) shows an anomalous glass-like behavior with a ≈ T 2 dependence at low temperatures and a plateau in a wide temperature range from about 20 to 260 K, surprisingly recovering the expected downturn for a crystal only for T > 300 K. The measured room temperature κ ≈ 1.6 W m −1 K −1 agrees with the calculated value, including three-phonon and isotope disorder scattering. However, the departure of the experimental from the calculated κ( T ) for T < 300 K, at the onset of the plateau, indicates that an additional scattering mechanism comes into play at lower temperatures. It is proposed that a tunneling two-level system associated with the BiO 6 octahedra rotation offers an additional phonon scattering mechanism and may explain the observed κ( T ) suppression. The findings may have significant implications for the pairing mechanism and unconventional superconductivity of doped-BaBiO 3 aside from suggesting it as a candidate building block for functional heterostructures.}, archive = {J_ADVS}, author = {Alexandre Henriques and Mariana S. L. Lima and Gøran J. Nilsen and Matthias J. Gutmann and Steffen Wirth and Walber H. Brito and Valentina Martelli}, doi = {10.1002/advs.202502379}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02379}, shortjournal = {Adv. Sci.}, title = {Anomalous glassy thermal conductivity in a perovskite bismuthate induced by structural dynamic instability}, volume = {12}, year = {2025}, }
• (2025). Radiation exposure induced Blood–Brain barrier injury via mitochondria-mediated sterile inflammation. ADVS, 12(31), e02356. (www)

  @article{ , abstract = {Radiation-induced brain injury (RIBI) is caused by exposure to high doses of ionizing radiation and characterized by severe cognitive dysfunction and brain necrosis. However, the pathogenesis of RIBI is not fully understood, and no effective intervention is available. This work describes a blood–brain barrier (BBB) microphysiological system (MPS), that allowed to explore the responses of BBB and distinct brain cells to radiation exposure. Following acute exposure to radiation of X-ray or γ-ray, characteristic RIBI-associated pathological responses are observed, including BBB compromise, DNA breaks, inhibited cell proliferation, cell hypertrophy, and proinflammatory cytokine release. Among the distinctive types of cells, brain endothelial cells show the highest radiosensitivity as compared to other cells in the MPS. Intriguingly, X-ray and γ-ray radiation consistently induce prominent sterile inflammation responses, especially type I interferon response, in the BBB MPS. These responses are mediated by radiation-induced mitochondrial DNA release and subsequent activation of cGAS-STING signaling pathway. Furthermore, it is found abrocitinib (JAK1 inhibitor) and idebenone (mitochondrial protectant) can attenuate radiation-induced inflammation and ameliorate injuries in the BBB MPS. These findings reveal the involvement of mitochondria-mediated sterile inflammation in RIBI pathogenesis, identifying mitochondria as a potential target for new radioprotective measures.}, archive = {J_ADVS}, author = {Peng Wang and Jiayue Liu and Min Zhang and Juan Yang and Peihan Lian and Xiu Cheng and Jianhua Qin}, doi = {10.1002/advs.202502356}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02356}, shortjournal = {Adv. Sci.}, title = {Radiation exposure induced Blood–Brain barrier injury via mitochondria-mediated sterile inflammation}, volume = {12}, year = {2025}, }
• (2025). Bionic nanostructures create mechanical signals to mediate the composite structural bone regeneration through multi-system regulation. ADVS, 12(31), e02299. (www)

  @article{ , abstract = {Regenerating bone defects has long been recognized as a significant clinical challenge. Drawing inspiration from the structure and properties of natural bone, bionic nanomaterials have emerged as a focal point in the field of bone tissue engineering. Unlike traditional scaffold materials, these advanced nanomaterials offer a remarkable capacity to replicate the intricate microenvironment of the stem cell niche. This ability facilitates enhanced migration, proliferation, and differentiation of stem cells, thereby promoting efficient new bone formation. Of particular significance is the application of contemporary nanotechnology, which enables the design of bone tissue engineering scaffolds with precisely tailored nanoscale characteristics. These include properties such as stiffness, pore size and porosity, nanomorphology, curvature, shear stress, viscoelasticity, hydrostatic pressure, and biochemical functionalities. Such customization affords precise control over stem cell behavior, guiding their cultivation or differentiation into desired phenotypes with spatial and temporal precision. Consequently, this approach significantly amplifies the efficacy of bone tissue regeneration. This article provides a comprehensive overview of the design principles and critical requirements for developing bionic nanomaterials as artificial stem cell niches. Furthermore, it consolidates current advancements in the field, examining various types of bionic nanomaterials and biomimetic technologies, alongside their diverse applications in bone tissue engineering.}, archive = {J_ADVS}, author = {Yangfan Pei and Yihan Wang and Jingxia Chen and Jing Zhou and Yuzhu Han and Xiuyu Liu and Siyu Chen and Sheng Chen and Dixin He and Yunxiao Wu and Huixin Lv and Yanmin Zhou}, doi = {10.1002/advs.202502299}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02299}, shortjournal = {Adv. Sci.}, title = {Bionic nanostructures create mechanical signals to mediate the composite structural bone regeneration through multi-system regulation}, volume = {12}, year = {2025}, }
• (2025). Novel quaternary ammonium salt-linked STING agonist antibody-drug conjugate: Synergistic activation of tumor immunity with mitigated off-target toxicity. ADVS, 12(31), e02270. (www)

  @article{ , abstract = {Immune-stimulating antibody conjugate (ISACs) incorporating STING agonists as payloads leverage both the targeting capability of the Fab region and the Fc region-mediated tumor antigen-dependent immune activation. Herein, a novel class of ISACs is reported, generated by engineering a quaternary ammonium-cleavable linker to conjugate diABZI STING agonist 3 (dSA3) with the HER2-targeting antibody Trastuzumab. The optimized ISAC (TZ-dSA3-12) demonstrated high potency, stability, enhanced solubility, and reduced off-target toxicity. The data showed that TZ-dSA3-12 potently activates the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies ( activity switch-on ). In contrast, TZ-dSA3-12 exhibited ≈75 fold lower activity than dSA3 in normal immune cells, where activation relies solely on the Fc region without Fab-mediated tumor antigen binding ( activity switch-off ). Furthermore, systemic administration of TZ-dSA3-12 at a dose (1 mg kg −1 ) elicited robust and sustained antitumor effect in a manner dependent on the activation of innate immunity and adaptive immunity, including macrophages, dendritic cells (DCs) and CD8 + T cells, while minimizing systemic cytokine release. Notably, TZ-dSA3-12 also induced immunological memory to combat the growth of rechallenged tumors. This innovative quaternary ammonium-linked STING agonist-ISAC represents a promising avenue for the future development of STING-targeted immunotherapy.}, archive = {J_ADVS}, author = {Yu Long and Borui Tang and Fei Xie and Lianqi Liu and Yangyihua Zhou and Jingwen Dong and Jianfeng Wang and Cuicui Sun and Yuting Wang and Ruoqi Li and Na Zhang and Liping Li and Longlong Luo and Junhai Xiao and Wu Zhong and Dian Xiao and Hongbin Deng and Xinbo Zhou}, doi = {10.1002/advs.202502270}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02270}, shortjournal = {Adv. Sci.}, title = {Novel quaternary ammonium salt-linked STING agonist antibody-drug conjugate: Synergistic activation of tumor immunity with mitigated off-target toxicity}, volume = {12}, year = {2025}, }
• (2025). Zoborg: On-demand climbing control for cyborg beetles. ADVS, 12(31), e02095. (www)

  @article{ , abstract = {Transitioning from horizontal surfaces to vertical walls is crucial for terrestrial robots to navigate complex environments. Replicating such impressive surface transitions in artificial insect-scale robots has been particularly challenging. Here, innovative control schemes are introduced that enable ZoBorg (a cyborg beetle from Zophobas morio ) to successfully climb walls from horizontal planes. The flex-rigid structure, flexible footpads, sharp claws, and embedded sensors of the living insect enable ZoBorg to achieve agile locomotion with exceptional adaptability, all at low power and low cost. ZoBorg crosses low-profile obstacles (5 and 8 mm steps) with a success rate exceeding 92% in less than one second. Most importantly, electrical stimulation of the elytron enables Zoborg to transition onto vertical walls with a success rate of 71.2% within 5 s. ZoBorg has potential applications for search and rescue missions due to its ability to traverse complex environments by crossing various obstacles, including low-profile steps, inclines, and vertical walls.}, archive = {J_ADVS}, author = {Lachlan Fitzgerald and H. Nhan Le and Robbie S. Wilson and H. Duoc Nguyen and Thanh Nho Do and T. Thang Vo-Doan}, doi = {10.1002/advs.202502095}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02095}, shortjournal = {Adv. Sci.}, title = {Zoborg: On-demand climbing control for cyborg beetles}, volume = {12}, year = {2025}, }
• (2025). Electronic microenvironment regulation of bismuth-salophen single-site catalysts for enhanced selectivity in CO2 electrolysis to formic acid. ADVS, 12(31), e02061. (www)

  @article{ , abstract = {Electrocatalytic CO 2 reduction reactions (CO 2 RR) hold significant industrial potential, with Bi-based catalysts demonstrating notable advantages in promoting the formation of formic acid (HCOOH). Despite progress, developing selective and efficient catalysts for CO 2 RR remains challenging. In this study, Bi single-site catalysts (SSCs) is designed modified with various electronegative groups (─F, ─H, and ─OMe (─OCH 3 )) to improve the CO 2 RR selectivity of Bi through atomic-level microenvironment tuning. Among these, ─F group-modulated Bi-Sal-F catalyst exhibited a high Faradaic efficiency (FE) of 95% for HCOOH within the current density range of −0.1 to −0.5 A cm −2 . In contrast, the microenvironment modification with the neutral ─H group and the electron-donating ─OMe group both led to decreased HCOOH selectivity and promoted HER. Combined with theoretical calculations, this is revealed that the microenvironment regulated by the ─F group strongly correlates with the catalytic activity of the metal center. By reducing the band gap and electron density of Bi, this microenvironment enhances the Bi center's ability to adsorb CO 2 via oxygen-coordinated, while effectively lowering the activation barrier for intermediate formation during CO 2 RR, thus promoting high selectivity for HCOOH production. This finding provides valuable theoretical insights and holds great potential for the design of highly efficient SSCs with microenvironment control.}, archive = {J_ADVS}, author = {Tianxing Wang and Tian (Leo) Jin and Zhiping Liu and Jingtao Wang and Yue Gong and Ming Ma and Jie Chen and Shaohua Shen and Rongqian Wu and Yu-Cheng Huang and Ying Rui Lu and Yi Lyu and Xiaofei Liu}, doi = {10.1002/advs.202502061}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e02061}, shortjournal = {Adv. Sci.}, title = {Electronic microenvironment regulation of bismuth-salophen single-site catalysts for enhanced selectivity in CO2 electrolysis to formic acid}, volume = {12}, year = {2025}, }
• (2025). VOx-based non-volatile radio-frequency switches for reconfigurable filter. ADVS, 12(31), e01989. (www)

  @article{ , abstract = {Vanadium oxide (VO x ) based memristor is a promising candidate for next-generation non-volatile memory and radio-frequency (RF) switches due to its compatibility with wafer-level integration and high-frequency operation. This work demonstrates high-performance VO x memristor with gold and silver electrodes, achieving a higher cutoff frequency compared to previously reported VO x devices. The devices exhibit long retention, high endurance (≈10 3 cycles), and nanosecond switching speeds, enabling the fabrication of RF switches with a cutoff frequency of ≈4.5 THz, low insertion loss (< 0.46 dB), and high isolation (>20 dB) from 0.1 to 20 GHz with stable operation extended to frequency up to 67 GHz. Leveraging these switches, a reconfigurable X-band bandpass filter whose is realized center frequency is tuned from 8.2 GHz in the OFF state to 7.6 GHz in the ON state, achieving a tunable range of ≈600 MHz. This demonstration paves the way for compact and versatile RF front-ends with improved frequency agility in advanced communication systems.}, archive = {J_ADVS}, author = {Dabin Seo and Dahyeon Kim and Jiyeon Ryu and Changwoo Pyo and Seungchan Lee and Tae-Sik Yoon and Myungsoo Kim}, doi = {10.1002/advs.202501989}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e01989}, shortjournal = {Adv. Sci.}, title = {VOx-based non-volatile radio-frequency switches for reconfigurable filter}, volume = {12}, year = {2025}, }
• (2025). Peptide-based biomaterials as a promising tool for cancer radiotherapy. ADVS, 12(31), e01775. (www)

  @article{ , abstract = {Radiotherapy (RT) is a mainstay therapeutic strategy for cancer; however, increasing radiation damage to tumor tissues while reducing the side effects on healthy tissues remains a great challenge. To address this issue, the use of biomaterials has proven promising. Recently, attention has been paid to peptide-based biomaterials as platforms for enhancing radiotherapeutic efficacy. This review explores peptide-based biomaterial-mediated tumor RT, including radiosensitizers and radiopharmaceuticals, with the aim of introducing emerging radiosensitive methods and RT strategies using radiopharmaceuticals. The advantages of peptide-based biomaterials, including controllable synthesis, good biocompatibility, targeting functions, and self-assembly performance, are introduced. These parameters must be considered in the rational design and optimization of peptide-based RT strategies. Peptide-based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted-peptide-modified radiosensitizers. Peptide-based radiopharmaceuticals are known as peptide-radionuclide conjugates (PRCs) and are categorized according to their peptide targets. Details of PRCs used in clinical studies and US Food and Drug Administration-approved PRCs are also presented. Finally, challenges in the clinical translation of peptide-based biomaterials as RT tools are highlighted.}, archive = {J_ADVS}, author = {Qian Wang and Xinhui Chu and Jianfeng Liu}, doi = {10.1002/advs.202501775}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e01775}, shortjournal = {Adv. Sci.}, title = {Peptide-based biomaterials as a promising tool for cancer radiotherapy}, volume = {12}, year = {2025}, }
• (2025). Pinosylvin inhibits inflammatory and osteoclastogenesis via NLRP3 inflammasome. ADVS, 12(31), e01532. (www)

  @article{ , abstract = {Pro-inflammatory cytokines such as TNF, IL-1, and IL-6 trigger aberrant osteoclastogenesis and result in massive bone loss. During RANKL-induced osteoclastogenesis, pyroptosis of macrophages/preosteoclasts acts as a pivotal mechanism for IL-1β release, thereby promoting osteoclast maturation and bone resorption. In the current study, it is observed that Pinosylvin (PIN), a compound extracted from European red pine, selectively inhibits LPS- and RANKL-induced release of IL-1β effectively reducing osteoclastogenesis. Notably, PIN inhibits the assembly of NLRP3 and the cleavage of GSDMD, pro-IL-1β, and pro-caspase-1, suggesting its therapeutic effects are NLRP3-targeted. Mechanistically, PIN blockes the NEK7/NLRP3 interaction, but not the NLRP3/ASC interaction, through its 3,5-dihydroxy groups by binding to NEK7, thereby inhibiting subsequent pyroptosis and osteoclastogenesis. Importantly, PIN alleviates inflammatory bone loss due to estrogen deficiency, reduces cranial bone destruction from local LPS injections, and improves survival in LPS-induced septic mice. This study uncovers the specific mechanism behind PIN's potent anti-inflammatory effects and identifies a new therapeutic target for NLRP3-driven diseases.}, archive = {J_ADVS}, author = {Wei Zhang and Xiangbing Wu and Wenming Li and Haifeng Zhang and Yijun Wang and Jing Xu and Wenhao Li and Yi Qin and Zebin Wu and Gaoran Ge and Shujun Lv and Lu Mao and Liangliang Wang and Dechun Geng}, doi = {10.1002/advs.202501532}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e01532}, shortjournal = {Adv. Sci.}, title = {Pinosylvin inhibits inflammatory and osteoclastogenesis via NLRP3 inflammasome}, volume = {12}, year = {2025}, }
• (2025). Testosterone delays bone microstructural destruction via osteoblast-androgen receptor-mediated upregulation of tenascin-C. ADVS, 12(31), e01518. (www)

  @article{ , abstract = {Bone loss and microstructural destruction in elderly men are associated with fractures and high mortality. While testosterone (Tes) is considered to be possibly protective, its regulatory mechanism in bone remodeling remains unclear. Here, bone microarchitectural analysis indicates that elderly men exhibit reduced cortical and trabecular thickness with elevated cortical porosity, particularly at the superior femoral head near the medial acetabulum. Serum profiling of 352 individuals showed that low Tes levels (<9.415 nmol·L −1 ) are associated with higher risk of bone loss. In vivo, tail-suspended mice lacking osteoblastic androgen receptor (AR) displayed similar femoral deterioration, with decreased trabecular bone and increased cortical porosity. Mechanistically, Tes enhances osteoblastic differentiation via AR-mediated upregulation of tenascin-C (TNC). Molecular docking suggests the fibrinogen C-terminal domain of TNC inhibits osteoclastogenesis by binding integrin αV, blocking adhesion of RGD-containing proteins. A synthetic peptide (pep2) mimicking this domain preserved bone architecture in osteoblast-specific Ar -knockout, tail-suspended mice. Moreover, elevated serum extracellular vesicle amyloid precursor protein, secondary to Tes-AR-TNC decline and osteoclast overactivation, emerged as a biomarker of bone loss when combined with low Tes. This study identifies the Tes-AR-TNC axis as a key regulator of male bone remodeling, offering insights into fracture risk assessment and targeted interventions in bone destruction.}, archive = {J_ADVS}, author = {Yong Xie and Meng Pan and Zeyuan Zhang and Licheng Zhang and Haotian Liu and Xia Wang and William W Lu and Peifu Tang and Wei Ge}, doi = {10.1002/advs.202501518}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e01518}, shortjournal = {Adv. Sci.}, title = {Testosterone delays bone microstructural destruction via osteoblast-androgen receptor-mediated upregulation of tenascin-C}, volume = {12}, year = {2025}, }
• (2025). Upcycling of waste fluororubber to photocurable high-performance vinyl-terminated liquid fluororubber by multifield coupling one-pot stepwise reactions. ADVS, 12(31), e01460. (www)

  @article{ , abstract = {To address the challenges of recycling and high-value utilization of waste fluororubbers, an effective method is reported for producing novel photocurable vinyl-terminated liquid fluororubbers (VTLF) with elevated fluorine content (63.1%), superior temperature resistance ( T 10% = 335 °C) from commercial waste fluororubbers. The approach employs a streamlined, multifaceted system (oxidative degradation/condensation reaction) integrating microwave, mechanical, and steady-state temperature fields. This system facilitates both efficient recycling and high-value transformation of waste fluororubbers. Initially, waste fluororubbers undergo controlled/oxidative degradation induced by alkali and hydrogen peroxide to yield carboxyl-terminated liquid fluororubbers (CTLF). Subsequently, condensation reaction system efficiently converts carboxyl groups into photoreactive vinyl groups. Ultimately, environmentally friendly and efficient photocuring of VTLF is achieved. The nonthermal effects of microwave fields reduce the total process time to just 1 h. The resulting photocured VTLF exhibits not only the comprehensive properties of conventional fluororubbers but also excellent chemical stability and unique light transmittance (94.21%). This study proposes a green, straightforward upcycling strategy within the circular economy framework to mitigate environmental issues associated with rubber's covalent crosslinking. Furthermore, it opens avenues for designing and synthesizing novel fluoropolymers for diverse applications.}, archive = {J_ADVS}, author = {Donghan Li and Lu Yu and Shurui Ning and Ping Li and Changle Chen and Dawei Zhao and Mingyi Liao and Qingshi Meng and Shixin Zhang and Qinghong Fang and Hailan Kang and Long Li and Jia Yang}, doi = {10.1002/advs.202501460}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e01460}, shortjournal = {Adv. Sci.}, title = {Upcycling of waste fluororubber to photocurable high-performance vinyl-terminated liquid fluororubber by multifield coupling one-pot stepwise reactions}, volume = {12}, year = {2025}, }
• (2025). A super-enhancer-driven transcriptional regulatory circuit underlying abiraterone resistance in castration-resistant prostate cancer. ADVS, 12(31), e01284. (www)

  @article{ , abstract = {Castration-resistant prostate cancer (CRPC) remains the leading cause of mortality among prostate cancer patients. While second-generation androgen receptor (AR) pathway-targeted therapies, such as Abiraterone, have significantly improved survival outcomes, resistance to these treatments ultimately emerges, posing a critical challenge. Understanding the mechanisms underlying Abiraterone resistance is essential for developing strategies to enhance patient outcomes. In this study, a super-enhancer (SE)-driven transcriptional regulatory circuit is identified involving BCL6, NFIB, and SMAD3 that facilitates Abiraterone resistance in CRPC. Through comprehensive analyses of SE expression profiles in Abiraterone-resistant CRPC cells and their parental counterparts, it is revealed that this circuit plays a pivotal role in resistance progression. Mechanistically, BCL6, NFIB, and SMAD3 synergistically remodel the transcriptional landscape of resistant CRPC cells, driving resistance by regulating cholesterol biosynthesis and cell cycle pathways. The findings provide critical insights into the transcriptional dysregulation underlying Abiraterone resistance and highlight potential therapeutic strategies to counteract treatment resistance in CRPC, ultimately aiming to improve patient survival and quality of life.}, archive = {J_ADVS}, author = {Liling Jiang and Jiamin Wang and Guanjie Peng and Haichuan Zhang and Jinxin Fang and Yingyin Gao and Enzhe Lou and Yangzhou Liu and Wa Ding and Bingyuan Liu and Qiong Mao and Lizhen Jiang and Aochu Liu and Xinyue Li and Shiwen Hu and Qiaomin Ma and Yueyuan Zheng and Zhigang Zhao and Xianping Shi}, doi = {10.1002/advs.202501284}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e01284}, shortjournal = {Adv. Sci.}, title = {A super-enhancer-driven transcriptional regulatory circuit underlying abiraterone resistance in castration-resistant prostate cancer}, volume = {12}, year = {2025}, }
• (2025). Neutrophil macrophage crosstalk via extracellular vesicles drives reverse migration in a fully human model of wound healing. ADVS, 12(31), e01036. (www)

  @article{ , abstract = {Persistent neutrophilic inflammation can lead to tissue damage and chronic inflammation, contributing to non-healing wounds. The resolution phase of neutrophilic inflammation is critical to preventing tissue damage. Animal models have provided insight into resolution of neutrophilic inflammation via efferocytosis and reverse migration (rM); however, species-specific differences and complexity of innate immune responses make translation to humans challenging. Thus, there is a need for in vitro systems that can elucidate mechanisms of resolution of human neutrophilic inflammation. Here, a human microphysiological system (MPS) is developed to mimic an inflammatory sterile injury (SI) microenvironment to study the role of macrophage-derived extracellular vesicles (M-EVs) in the resolution of inflammation via neutrophil rM. The MPS integrates a blood vessel mimic, injury site spheroid, human neutrophils, macrophages, and macrophage-derived EVs to investigate the role of M-EVs in neutrophil rM in vitro. The MPS enabled demonstration that EVs derived from macrophage subsets modulate migratory behavior in primary neutrophils differently in specific inflammatory microenvironments. A new mechanism is identified underlying neutrophil rM, where neutrophils exposed to M2-EV-derived-IL-8 migrate away from the SI site. Overall, the SI MPS system demonstrates a reverse migratory pattern in human primary neutrophils, advancing the study of the resolution of inflammation via M-EVs.}, archive = {J_ADVS}, author = {Kehinde Adebayo Babatunde and Oluwadamilola Fatimat Babatunde and Adeel Ahmed and Wilmara Salgado-Pabon and David J Beebe and Sheena C. Kerr}, doi = {10.1002/advs.202501036}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e01036}, shortjournal = {Adv. Sci.}, title = {Neutrophil macrophage crosstalk via extracellular vesicles drives reverse migration in a fully human model of wound healing}, volume = {12}, year = {2025}, }
• (2025). Superior-selective and complete recycling of trace precious metals from wastewater by magnetic trilayer carbon-aerogels. ADVS, 12(31), e00858. (www)

  @article{ , abstract = {It is a considerable challenge to selectively recycle precious metals from industrial wastewater and natural waters. Herein, carbon aerogels embedded with magnetic Fe@FeS@C nanoparticles (CFeS aerogels) were constructed from natural carrageenan. The unique redox potential of FeS, coupled with the barrier effect and the electron conduction property of the carbon layer, made the Fe@FeS@C nanoparticles exhibited the ultra-high ion selectivity. The resultant CFeS aerogels can selectively adsorb and reduce trace Au(III), Ag(I), and Pd(II) ions at ppb level in an aqueous solution with 29 coexisting cations. Even if the concentration of competing metal ions is 100-fold higher than those of the precious metal ions, the selectivity for Au(III), Ag(I), and Pd(II) ions remained above 99.2%. Moreover, the 3D carbon network immobilizing the Fe@FeS@C nanoparticles prevented the aggregation and detachment of the recycled precious metals, thereby enhancing the adsorption rate and capacity. CFeS aerogels rapidly achieved adsorption equilibrium for Au(III), Ag(I), and Pd(II) ions in 5–10 min, and have the saturated adsorption capacities of 321.2 mg·g −1 , 150.6 mg·g −1 , and 70.1 mg·g −1 , respectively. Such aerogels with ultra-high selectivity, high efficiency, and easy separation provided a practical strategy for the enrichment and recovery of the precious metals.}, archive = {J_ADVS}, author = {Jianzheng Yang and Yan Zhou and Shang Du and Bing Wu and Jianying Zhang and Shanjun Song and Tao Zhou and Jinming Zhang}, doi = {10.1002/advs.202500858}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e00858}, shortjournal = {Adv. Sci.}, title = {Superior-selective and complete recycling of trace precious metals from wastewater by magnetic trilayer carbon-aerogels}, volume = {12}, year = {2025}, }
• (2025). Unveiling formation pathways of ternary I–III–VI CuInS2 quantum dots and their effect on photoelectrochemical hydrogen generation. ADVS, 12(31), e00829. (www)

  @article{ , abstract = {Understanding the formation mechanisms of semiconductor nanocrystal quantum dots (QDs) is essential for fine-tuning their optical and electrical properties. Despite their potential in solar energy conversion, the synthesis processes and resulting properties of ternary I–III–VI QDs remain underexplored due to the complex interplay among their constituent elements. Herein, the formation mechanism of ternary I–III–VI CuInS 2 QDs is investigated, and a direct correlation between their synthesis pathways and photoelectrochemical hydrogen generation performance is established. Two distinct formation pathways governed by the Lewis acid strength of the precursors are revealed. Precursors with weaker Lewis acid strength, such as indium acetate–alkylamine complexes, induce the nucleation of Cu x S phases, which subsequently transform into CuInS 2 QDs. Conversely, exemplified by indium iodide–alkylamine complexes, precursors with stronger Lewis acid strength enable the simultaneous incorporation of all elements during nucleation, resulting in the direct formation of CuInS 2 QDs. Notably, QDs synthesized through this direct pathway exhibit significantly improved electrical properties with lower electron trap densities, resulting in outstanding photoelectrochemical hydrogen production with an excellent photocurrent density of 11.3 mA cm −2 at 0.6 V RHE when used as sensitizers in photoanodes. These findings highlight the critical role of formation pathways in tailoring the properties of ternary I–III–VI QDs.}, archive = {J_ADVS}, author = {Hyo Cheol Lee and Hwapyong Kim and Kiwook Kim and Kyunghoon Lee and Wookjin Chung and Seung Beom Ha and Minseo Kim and Eonhyoung Ahn and Shi Li and Seunghyun Ji and Gyudong Lee and Hyeonjong Ma and Sung Jun Lim and Hongsoo Choi and Jae-Yup Kim and Hyungju Ahn and Su-Il In and Jiwoong Yang}, doi = {10.1002/advs.202500829}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e00829}, shortjournal = {Adv. Sci.}, title = {Unveiling formation pathways of ternary I–III–VI CuInS2 quantum dots and their effect on photoelectrochemical hydrogen generation}, volume = {12}, year = {2025}, }
• (2025). Covalent bridges in bi loaded BiVO4 enabling rapid charge transfer for efficient photocatalytic water oxidation. ADVS, 12(31), e00666. (www)

  @article{ , abstract = {Bismuth vanadate (BiVO 4 ) is known as one of the most potential candidates in photocatalytic water oxidation for supplying oxygen in extreme environment. However, its photocatalytic oxygen evolution is hindered by the rapid photogenerated charge carrier separation efficiency. Herein, plasmonic bismuth (Bi) nanoparticles loaded BiVO 4 is prepared for photocatalytic water oxidation. Specifically, the plasmonic bismuth nanoparticles are in situ loaded on the BiVO 4 via reduction of partial BiVO 4 , allowing the formation of the Bi─O─V covalent bridges. Based on the femtosecond transient absorption spectroscopy and density functional theory calculations, such Bi─O─V covalent bridges can significantly facilitate the migration of the plasmonic-induced hot electrons from Bi to BiVO 4 , allowing more photogenerated charge carrier to participate in the surface reaction. As a result, the optimized Bi/BiVO 4 demonstrates a record-high photocatalytic evolution rate of 4567.94 µmol h −1 g −1 . More importantly, the obtained Bi/BiVO 4 show plausible photocatalytic water oxidation capability (oxygen production rate of 381.47 µmol h −1 g −1 ) under near-infrared light irradiation, further collaborating its potential to be utilized in extreme conditions. This work on design of low-cost and highly-efficient photocatalysts for water oxidation is anticipated to push forward the development of photocatalytic oxygen production in various application scenarios.}, archive = {J_ADVS}, author = {Liyang Li and Zhiming Chen and Dong Fang and Jingxiang Low and Jianhong Yi}, doi = {10.1002/advs.202500666}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e00666}, shortjournal = {Adv. Sci.}, title = {Covalent bridges in bi loaded BiVO4 enabling rapid charge transfer for efficient photocatalytic water oxidation}, volume = {12}, year = {2025}, }
• (2025). QSOX2-mediated disulfide bond modification enhances tumor stemness and chemoresistance by activating TSC2/mTOR/c-myc feedback loop in esophageal squamous cell carcinoma. ADVS, 12(31), e00597. (www)

  @article{ , abstract = {Disulfide bond modification is critical in maintaining protein structure and activity, but its roles in regulating tumor stemness and chemoresistance remain underexplored. Here, Quiescin Sulfhydryl Oxidase 2 (QSOX2) is identified, a protein involved in disulfide bond formation, is highly expressed in esophageal squamous cell carcinoma (ESCC), and is associated with poor patient prognosis. Functional analyses demonstrated that QSOX2 overexpression markedly potentiated tumor stemness and further promoted chemoresistance, proliferation, and metastasis of ESCC cells. Mechanistically, QSOX2 enhances disulfide bond formation in TSC Complex Subunit 2 (TSC2), stabilizing TSC2-Akt interactions, facilitating phosphorylation of TSC2 at the Ser939 by Akt, and further activating mTOR/4E-BP1/c-Myc signaling axis. Intriguingly, cancer-associated fibroblasts-secreted IGF-1 upregulates QSOX2 expression via IGF1R/Akt/mTOR/c-Myc pathway, establishing a positive feedback loop that sustains ESCC cell stemness. Targeting QSOX2 with Ebselen, in combination with mTOR inhibitor Rapamycin and chemotherapy, effectively downregulates c-Myc expression and induces tumor dormancy in a mouse xenograft model. Therefore, the findings reveal that QSOX2-mediated disulfide bond modification enhances tumor stemness by activating mTOR signaling, highlighting a promising therapeutic target in ESCC.}, archive = {J_ADVS}, author = {Wo-Ming Chen and Xiao-Ping Zhang and Xiao Sun and Hai-Cheng Liu and Yuan-Yuan Yan and Xue Wei and Yu Liang and Yue Feng and Zhengjie Chen and Yongxu Jia and Chen Jiang and Qian Yan and Lei Li}, doi = {10.1002/advs.202500597}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e00597}, shortjournal = {Adv. Sci.}, title = {QSOX2-mediated disulfide bond modification enhances tumor stemness and chemoresistance by activating TSC2/mTOR/c-myc feedback loop in esophageal squamous cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). An anisotropic gold-palladium heterostructured nanosystem for synergistically overcoming radioresistance and enhancing melanoma radioimmunotherapy. ADVS, 12(31), e00492. (www)

  @article{ , abstract = {Radiotherapy (RT) has recently reemerged as a promising approach for melanoma treatment because of its potential to trigger abscopal effects. However, the intrinsic radioresistance of melanoma significantly diminishes RT-induced DNA damage and the subsequent release of immunostimulatory molecules, thereby impairing systemic antitumor immunity. To overcome these challenges, a multifunctional anisotropic Au-Pd heterostructured nanosystem (APSMR) is developed that incorporates a plasmonically enhanced Au-Pd core, with a shell composed of a biodegradable, Mn-doped targeting peptide. The nanosystem integrates photothermal, radiotherapeutic, and immunomodulatory functions. Under 1064 nm laser irradiation, APSMR generates reactive oxygen species (ROS) via plasmon-driven catalysis and Mn-mediated Fenton-like reactions. Concurrently, mild hyperthermia (HT) promotes oxygenation and disrupts DNA repair pathways, resulting in multi-directional DNA damage and an increase in immunogenic cell death (ICD). Furthermore, the release of Mn 2 ⁺ ions activates the cGAS–STING pathway, which synergizes with ICD to promote systemic antitumor immunity. Notably, APSMR treatment also upregulates PD-L1 expression, thereby sensitizing tumors to immune checkpoint blockade. Collectively, APSMR offers a potent and synergistic strategy to amplify RT-driven tumor vaccination and improve therapeutic responses against metastatic melanoma.}, archive = {J_ADVS}, author = {Cheng Chen and Yuqi Huang and Wandong Wang and Minghao Chao and Weiguo Sun and Yinghui Kong and Guan Jiang and Yong Gao and Fenglei Gao}, doi = {10.1002/advs.202500492}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e00492}, shortjournal = {Adv. Sci.}, title = {An anisotropic gold-palladium heterostructured nanosystem for synergistically overcoming radioresistance and enhancing melanoma radioimmunotherapy}, volume = {12}, year = {2025}, }
• (2025). Tactile augmentation of material classification via imperceptible on-skin triboelectricity collection. ADVS, 12(31), e00217. (www)

  @article{ , abstract = {Harnessing intrinsic triboelectric signals from human skin holds promise for enhancing tactile perception. However, collecting these signals without disrupting normal skin functions and convoluting motion artifacts remains challenging. Additionally, person-to-person signal variance complicates data processing. In this study, it is demonstrated that triboelectric signals generated from touch can be imperceptibly collected and processed using a machine learning model to achieve tactile augmentation. When one hand contacts and rubs against a target object, charge transfer occurs between the skin and the object's surface. By placing a substrate-less microfiber electrode on the finger of the other hand, a body-coupled triboelectric circuit is formed to collect these signals, which contain material-specific features such as amplitude and peak ratio. A machine learning technique is developed to process the triboelectric signals, enabling the classification of six different materials with a prediction accuracy of ≈95%. The material differentiation model is further validated across different users, achieving an overall accuracy of ≈88 %, illustrating the potential of utilizing the body-coupled triboelectric circuit for tactile augmentation.}, archive = {J_ADVS}, author = {Junting Huang and Stanley Gong Sheng Ka and Haydn Cheong and Yaru Zhang and Daping Chu and Sohini Kar-Narayan and Wenyu Wang and Yan Yan Shery Huang}, doi = {10.1002/advs.202500217}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e00217}, shortjournal = {Adv. Sci.}, title = {Tactile augmentation of material classification via imperceptible on-skin triboelectricity collection}, volume = {12}, year = {2025}, }
• (2025). An engineered soluble single-chain TCR engager for KRAS-G12V specific tumor immunotherapy. ADVS, 12(31), e00181. (www)

  @article{ , abstract = {T cell receptor (TCR) based immunotherapy is an attractive strategy to target a wide range of intra-tumoral antigens and elicit robust tumor cytotoxicity. However, engineering soluble TCR engagers that preserve physiological affinity is crucial for universal TCR drug development, yet remains challenging. In the present study, multiple TCR engagers featuring diverse architectures based on the KRAS-G12V specific 1–2C TCR in the context of HLA-A*11:01 is designed and evaluated. Notably, a soluble tandem double single-chain TCR (STanD-scTCR) engager, comprising two repeated single-chain variable fragment (scFv) TCRs, exhibit enhanced binding avidity and potent T-cell activation. Through site-directed mutagenesis, T96F mutation (T96F-TCR) within the TCR β chain is identified, which substantially augment T cell reactivity while maintaining physiological affinity and minimizing off-target cross-reactivity. The T96F-mutated STanD-scTCR engager demonstrates improved antigen sensitivity, promotes multi-functional T-cell responses, and facilitates immune synapse formation between T cells and target cells. In a xenograft tumor model harboring the KRAS-G12V mutation, the TCR engager displays substantial tumor suppression efficacy. These findings underscore the therapeutic potential of 1–2C STanD-scTCR engage in targeting KRAS-G12V mutations in the context of HLA-A*11:01. Furthermore, the engineering strategies employ in the development of STanD-scTCR engager provide an invaluable for future designs of TCR engager drugs.}, archive = {J_ADVS}, author = {Keke Ma and Jie Wang and Min Jiang and Juanhua He and Fangyang Li and Dan Lu and Chao Su and Yan Chai and Wenjing Jin and Yu Chen and Catherine W.H. Zhang and Xiaopeng Ma and Hui Tan and George F. Gao and Shuguang Tan}, doi = {10.1002/advs.202500181}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e00181}, shortjournal = {Adv. Sci.}, title = {An engineered soluble single-chain TCR engager for KRAS-G12V specific tumor immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Advanced pharmaceutical nanotechnologies applied for chinese herbal medicines. ADVS, 12(31), e00167. (www)

  @article{ , abstract = {Over centuries of clinical practice, Chinese herbal medicines (CHMs) have gained widespread recognition for their efficacy in treating various diseases. However, their complex material basis and relatively mild therapeutic efficacy limit their modernization and quality control. Recently, the application of pharmaceutical nanotechnology to CHMs has not only enhanced their efficacy, but also helped elucidate their material basis, thereby substantially advancing their modernization. Nano-modified CHMs have shown improvements in multiple aspects, such as bioavailability, targeting ability, toxicity reduction, and sustained release. In this review, nano-strategies for emerging, revolutionary, and promising pathways for modernizing CHMs are revealed. First, the development, application potential, particularities, and limitations of CHMs are reviewed. Subsequently, a systematic and comprehensive analysis of the two nano-strategies for optimizing CHMs are presented, highlighting the distinct characteristics of the carrier-free and carrier-based approaches. The specific advantages of these strategies, including improved bioavailability, increased targeting ability, reduced toxicity, and controlled release, are discussed. The novel research directions resulting from the application of pharmaceutical nanotechnology to CHMs are also explored, such as elucidating CHM treatment theories, combining traditional Chinese medicine topical therapies, drug screening, and expanding innovative drug formulations. Finally, the challenges and opportunities in this field are addressed to inspire future research.}, archive = {J_ADVS}, author = {Jiameng Li and Ya-Li Zhang and Tong Jin and Zhaokui Jin and Mengliang Zhu and Guangchao Qing and Jinchao Zhang and Zhisen Wang and Yan Mu and Jin Li and Qian Hua and Xing-Jie Liang}, doi = {10.1002/advs.202500167}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {e00167}, shortjournal = {Adv. Sci.}, title = {Advanced pharmaceutical nanotechnologies applied for chinese herbal medicines}, volume = {12}, year = {2025}, }
• (2025). Mercaptophenylboronic acid-mediated nanozyme immunochromatographic assay for simultaneous detection of respiratory bacteria and virus. ADVS, 12(31), 2502574. (www)

  @article{ , abstract = {Rapid, sensitive, and accurate detection of respiratory pathogens is essential yet challenging. Here, this study presents a universal nanozyme immunochromatographic assay (ICA) that utilizes the broad binding capacity of 4-mercaptophenylboronic acid (MPBA) for glycosylated molecules on bacterial and viral surfaces, along with the colorimetric-catalytic dual enhancement capability of multi-tentacle magnetic nanozyme (FeAu@AuIr), to achieve ultrasensitive, wide-range, and simultaneous detection of multiple respiratory pathogens. The virus-like biomimetic FeAu@AuIr with multi-tentacle shell is prepared by sequentially assembling a layer of large Au nanoparticles and a layer of highly catalytic 5 nm AuIr nanoparticles on 160 nm Fe 3 O 4 surface, greatly enhancing the universal capture/detection capability of detection system for both bacteria and virus. By simultaneously detecting two significant respiratory bacteria ( Streptococcus pneumoniae and Pseudomonas aeruginosa ) and one respiratory virus (Severe Acute Respiratory Syndrome Coronavirus 2), this study demonstrates that combination of FeAu@AuIr-MPBA probe and antibody-modified ICA strips can achieve ultrasensitive and highly specific detection of different respiratory pathogens, with sensitivity and detection range improved by more than 238 times compared to existing colorimetric ICA methods. Moreover, the practical utility of the FeAu@AuIr-based ICA is validated through testing 170 positive clinical respiratory samples, underscoring its considerable potential for real-time pathogen detection in both clinical and field settings.}, archive = {J_ADVS}, author = {Qing Yu and Jiaxuan Li and Shuai Zheng and Yajin Hu and Benshun Tian and Meirou Lu and Bing Gu and Chongwen Wang}, doi = {10.1002/advs.202502574}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {2502574}, shortjournal = {Adv. Sci.}, title = {Mercaptophenylboronic acid-mediated nanozyme immunochromatographic assay for simultaneous detection of respiratory bacteria and virus}, volume = {12}, year = {2025}, }
• (2025). Attenuated nuclear tension regulates progerin-induced mechanosensitive nuclear wrinkling and chromatin remodeling. ADVS, 12(31), 2502375. (www)

  @article{ , abstract = {Hutchinson–Gilford progeria syndrome, caused by a mutation in the LMNA gene, leads to increased levels of truncated prelamin A, progerin, in the nuclear membrane. The accumulation of progerin results in defective nuclear morphology and is associated with altered expression of linker of the nucleoskeleton and cytoskeleton complex proteins, which are critical for nuclear signal transduction via molecular coupling between the extranuclear cytoskeleton and lamin-associated nuclear envelope. However, the molecular mechanisms underlying progerin accumulation-induced nuclear deformation and its effects on intranuclear chromosomal organization remain unclear. Here, the spatiotemporal evolution of nuclear wrinkles is analyzed in response to variations in substrate stiffness using a doxycycline-inducible progerin expression system. It is found that cytoskeletal tension regulates the onset of progerin-induced nuclear envelope wrinkling and that the molecular interaction between SUN1 and LMNA controls the actomyosin-dependent attenuation of nuclear tension. Genome-wide analysis of chromatin accessibility and gene expression further suggests that an imbalance in force between the intra- and extranuclear spaces induces nuclear deformation, which specifically regulates progeria-associated gene expression via modification of mechanosensitive signaling pathways. The findings highlight the crucial role of nuclear lamin–cytoskeletal connectivity in bridging nuclear mechanotransduction and the biological aging process.}, archive = {J_ADVS}, author = {Ji-Eun Park and Juhyeon Jo and Kun Xu and Sun-Ah Lee and Seong-Beom Han and YigJi Lee and Won-Ki Cho and Bo Li and Soo Hyun Kim and Dong-Hwee Kim}, doi = {10.1002/advs.202502375}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {2502375}, shortjournal = {Adv. Sci.}, title = {Attenuated nuclear tension regulates progerin-induced mechanosensitive nuclear wrinkling and chromatin remodeling}, volume = {12}, year = {2025}, }
• (2025). Plasma DNMT1 activity for assessing tumor burden and predicting neoadjuvant therapy response in breast cancer. ADVS, 12(31), 2501064. (www)

  @article{ , abstract = {DNA methylation is mediated by DNA methyltransferases (DNMTs), and the stability of their activity is essential for cellular fate. DNMT1 is considered one of the most promising targets for research. However, current detection techniques are limited in accurately quantifying its activity in peripheral blood. Here, a reaction system is developed known as DNMT1 Identification by Variable Activity (DIVA) for the highly sensitive detection of DNMT1 activity in the peripheral blood of breast cancer patients. DIVA can detect DNMT1 at levels as low as 10 −7 U mL −1 , with minimal time and cost. This method is applied to analyze 271 clinical samples, successfully evaluating tumor burden in patients staged I-IV. Finally, this method is utilized to assess the prognosis of 22 patients undergoing neoadjuvant therapy, demonstrating good consistency with ultrasound imaging results. It is believed that DIVA could serve as an effective auxiliary technique for both the early detection of breast cancer and evaluation of neoadjuvant therapy.}, archive = {J_ADVS}, author = {Yingran Wang and Guozhi Zhang and Zhizhao Zhang and Mengsi Zhang and Jiao Chen and Ke Wang and Lu Liu and Jing Bao and Ming Chen and Xiaowei Qi and Mingxuan Gao}, doi = {10.1002/advs.202501064}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {2501064}, shortjournal = {Adv. Sci.}, title = {Plasma DNMT1 activity for assessing tumor burden and predicting neoadjuvant therapy response in breast cancer}, volume = {12}, year = {2025}, }
• (2025). Mechanical forces guide axon growth through the nigrostriatal pathway in an organotypic model. ADVS, 12(31), 2500400. (www)

  @article{ , abstract = {Reconstructing the nigrostriatal pathway is one of the major challenges in cell replacement therapies for Parkinson's disease due to the lack of enabling technologies capable of guiding the reinnervation of dopaminergic precursors transplanted into the substantia nigra toward the striatum. This paper examines nano-pulling, as a technology to enable the remote manipulation of axonal growth. Specifically, an organotypic model consisting of co-cultures of the substantia nigra and the striatum is developed to demonstrate that when cortical neural progenitors are transplanted into the substantia nigra, nano-pulling can guide and enhance the elongation of neural projections toward the striatum. To provide additional evidence, induced pluripotent stem cell-derived dopaminergic progenitor neurospheres are generated and it is shown that nano-pulling can induce guided growth and promote the maturation of their neural processes. Altogether, this study demonstrates the potential of nano-pulling as an emerging technique to promote directed reinnervation within the central nervous system.}, archive = {J_ADVS}, author = {Sara De Vincentiis and Elena Capitanini and Karen Kira and Claudia Dell'Amico and Jun Takahashi and Marco Onorati and Fabian Raudzus and Vittoria Raffa}, doi = {10.1002/advs.202500400}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {2500400}, shortjournal = {Adv. Sci.}, title = {Mechanical forces guide axon growth through the nigrostriatal pathway in an organotypic model}, volume = {12}, year = {2025}, }
• (2025). Sugar functionalized collagen material for local modulation of innate immunity. ADVS, 12(31), 2415364. (www)

  @article{ , abstract = {Small alterations during the early stages of the innate immune response to an implant can drive large changes in adaptive immunity. Biomaterials for regenerative purposes can be engineered to modulate this immune response in beneficial ways. This study presents an innovative patch designed and functionalized to target the innate immunity at the implant site. Mannose moieties are incorporated into collagen patches, resulting in a technology called Local Immunotuning Patch (LIP), designed to directly interact with antigen presenting cells through their mannose receptor. In vitro, LIP shows anti-inflammatory effects on bone marrow-derived macrophages and inhibitory properties even on methicillin-resistant bacterial strains. Subcutaneous implantation in mice reveals that LIP modulates multiple pathways related to innate and adaptive immunity, underscoring its role in shaping an immune-engineered environment around the implant. These findings highlight the potential of this strategy to control the foreign body reaction at the implant site, making it applicable for various uses, including wound healing and surgical infection control in reconstructive procedures.}, archive = {J_ADVS}, author = {Francesca Taraballi and Claudia Corbo and Julia Enterria-Rosales and John Otto Martinez and Silvia Minardi and Laura Pandolfi and Xing Wang and Ennio Tasciotti and Kavindra V. Singh and Cesar A. Arias and Bruna Corradetti}, doi = {10.1002/advs.202415364}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {2415364}, shortjournal = {Adv. Sci.}, title = {Sugar functionalized collagen material for local modulation of innate immunity}, volume = {12}, year = {2025}, }
• (2025). The morphological, behavioral, and transcriptomic life cycle of anthrobots. ADVS, 12(31), 2409330. (www)

  @article{ , abstract = {Fascinating aspects of morphogenetic and behavioral plasticity of living material are revealed by novel constructs that self-construct from genetically wild-type cells. Anthrobots arise from cultured adult human airway epithelial cells, developing, becoming self-motile, and acquiring neural repair capabilities without exogenous genetic circuits or inorganic scaffolds. Progress in bioengineering and regenerative medicine depends on developing a predictive understanding of collective cell behavior in novel circumstances. Toward that end, here a number of life cycle properties of Anthrobots, including their morphogenesis, maturation, and demise, are quantitatively characterized. A self-healing capacity and a remarkable reduction of epigenetic age upon morphogenesis are uncovered. Transcriptomic analysis reveals that assembling into Anthrobots drives a massive remodeling of gene expression relative to their cellular source, including several embryonic patterning genes, and a shift toward more evolutionarily ancient gene expression. These data reveal new aspects of engineered multicellular configurations, in which wild-type adult human cells self-assemble into an active living construct with its own distinct transcriptome, morphogenesis, and life history.}, archive = {J_ADVS}, author = {Gizem Gumuskaya and Nikolai Davey and Pranjal Srivastava and Andrew Bender and Léo Pio-Lopez and Douglas Hazel and Michael Levin}, doi = {10.1002/advs.202409330}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {2409330}, shortjournal = {Adv. Sci.}, title = {The morphological, behavioral, and transcriptomic life cycle of anthrobots}, volume = {12}, year = {2025}, }
• (2025). Multivariate screening and automated clustering of macrophage immunoreactome to nanoparticles and photothermal therapy. ADVS, 12(31), 2405860. (www)

  @article{ , abstract = {Immunotherapy aims to control the immune system against diseases such as cancer or infections. Nanotechnology is part of the armamentarium to reprogram the immune system in a spatially and temporally controlled manner. However, predicting immune responses using high-throughput tests is challenging due to the immunoreactome's complexity and plasticity. This work presents a fast, machine learning-assisted predictive assay to classify the multifactorial immune responses to any kind of treatments. Engineered human THP-1 monocytes differentiated and polarized into M0, M1, and M2 macrophages are used to monitor nuclear factor Kappa B (NF-kB) and interferon regulatory factor (IRF) pathway activations and gene expression profile in response to metallic nanoparticles (NPs), activated or not by light to induce photothermal therapy (PTT). Principal component analysis (PCA) reveals distinct responses to nanoparticles and the reprogramming toward inflammatory macrophage triggered by PTT. Gold-iron oxide nanoflowers and magnetosomes per se favor polarization toward M2 profile, while light activation shifts this M2-like macrophages toward an M1 phenotype. These findings, confirmed on human blood derived monocytes shed light on the intricate immunomodulatory effects of nanoparticles and PTT on macrophage behavior and provide a basis for an adaptable screening method for the predictive design of therapeutic strategies for immunotherapy in cancer and other diseases.}, archive = {J_ADVS}, author = {Sonia Becharef and Léa Jabbour and Nassima Bekaddour and Giulio Avveduto and Nathalie Luciani and Gautier Laurent and Rana Bazzi and Edouard Alphandery and Stéphane Roux and Amanda K. A. Silva and Kelly Aubertin and Jean-Philippe Herbeuval and Florence Gazeau}, doi = {10.1002/advs.202405860}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {2405860}, shortjournal = {Adv. Sci.}, title = {Multivariate screening and automated clustering of macrophage immunoreactome to nanoparticles and photothermal therapy}, volume = {12}, year = {2025}, }
• (2025). Zoborg: On-demand climbing control for cyborg beetles (Adv. sci. 31/2025). ADVS, 12(31), 71210. (www)

  @article{ , archive = {J_ADVS}, author = {Lachlan Fitzgerald and H. Nhan Le and Robbie S. Wilson and H. Duoc Nguyen and Thanh Nho Do and T. Thang Vo-Doan}, doi = {10.1002/advs.71210}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71210}, shortjournal = {Adv. Sci.}, title = {Zoborg: On-demand climbing control for cyborg beetles (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). The morphological, behavioral, and transcriptomic life cycle of anthrobots (Adv. sci. 31/2025). ADVS, 12(31), 71198. (www)

  @article{ , archive = {J_ADVS}, author = {Gizem Gumuskaya and Nikolai Davey and Pranjal Srivastava and Andrew Bender and Léo Pio-Lopez and Douglas Hazel and Michael Levin}, doi = {10.1002/advs.71198}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71198}, shortjournal = {Adv. Sci.}, title = {The morphological, behavioral, and transcriptomic life cycle of anthrobots (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). Mechanical forces guide axon growth through the nigrostriatal pathway in an organotypic model (Adv. sci. 31/2025). ADVS, 12(31), 71197. (www)

  @article{ , archive = {J_ADVS}, author = {Sara De Vincentiis and Elena Capitanini and Karen Kira and Claudia Dell'Amico and Jun Takahashi and Marco Onorati and Fabian Raudzus and Vittoria Raffa}, doi = {10.1002/advs.71197}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71197}, shortjournal = {Adv. Sci.}, title = {Mechanical forces guide axon growth through the nigrostriatal pathway in an organotypic model (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). Attenuated nuclear tension regulates progerin-induced mechanosensitive nuclear wrinkling and chromatin remodeling (Adv. sci. 31/2025). ADVS, 12(31), 71194. (www)

  @article{ , archive = {J_ADVS}, author = {Ji-Eun Park and Juhyeon Jo and Kun Xu and Sun-Ah Lee and Seong-Beom Han and YigJi Lee and Won-Ki Cho and Bo Li and Soo Hyun Kim and Dong-Hwee Kim}, doi = {10.1002/advs.71194}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71194}, shortjournal = {Adv. Sci.}, title = {Attenuated nuclear tension regulates progerin-induced mechanosensitive nuclear wrinkling and chromatin remodeling (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). Sugar functionalized collagen material for local modulation of innate immunity (Adv. sci. 31/2025). ADVS, 12(31), 71193. (www)

  @article{ , archive = {J_ADVS}, author = {Francesca Taraballi and Claudia Corbo and Julia Enterria-Rosales and John Otto Martinez and Silvia Minardi and Laura Pandolfi and Xing Wang and Ennio Tasciotti and Kavindra V. Singh and Cesar A. Arias and Bruna Corradetti}, doi = {10.1002/advs.71193}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71193}, shortjournal = {Adv. Sci.}, title = {Sugar functionalized collagen material for local modulation of innate immunity (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). Multivariate screening and automated clustering of macrophage immunoreactome to nanoparticles and photothermal therapy (Adv. sci. 31/2025). ADVS, 12(31), 71192. (www)

  @article{ , archive = {J_ADVS}, author = {Sonia Becharef and Léa Jabbour and Nassima Bekaddour and Giulio Avveduto and Nathalie Luciani and Gautier Laurent and Rana Bazzi and Edouard Alphandery and Stéphane Roux and Amanda K. A. Silva and Kelly Aubertin and Jean-Philippe Herbeuval and Florence Gazeau}, doi = {10.1002/advs.71192}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71192}, shortjournal = {Adv. Sci.}, title = {Multivariate screening and automated clustering of macrophage immunoreactome to nanoparticles and photothermal therapy (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). Plasma DNMT1 activity for assessing tumor burden and predicting neoadjuvant therapy response in breast cancer (Adv. sci. 31/2025). ADVS, 12(31), 71191. (www)

  @article{ , archive = {J_ADVS}, author = {Yingran Wang and Guozhi Zhang and Zhizhao Zhang and Mengsi Zhang and Jiao Chen and Ke Wang and Lu Liu and Jing Bao and Ming Chen and Xiaowei Qi and Mingxuan Gao}, doi = {10.1002/advs.71191}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71191}, shortjournal = {Adv. Sci.}, title = {Plasma DNMT1 activity for assessing tumor burden and predicting neoadjuvant therapy response in breast cancer (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). Unraveling the atomic mechanism of the crystalline phase-dependent structural features and special spectral design of α-, β-, and Ɛ-Ga₂O₃ (Adv. sci. 31/2025). ADVS, 12(31), 71190. (www)

  @article{ , archive = {J_ADVS}, author = {Xinqing Han and Yong Liu and Yang Li and Miguel L. Crespillo and Eva Zarkadoula and Wenxiang Mu and Peng Liu}, doi = {10.1002/advs.71190}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71190}, shortjournal = {Adv. Sci.}, title = {Unraveling the atomic mechanism of the crystalline phase-dependent structural features and special spectral design of α-, β-, and Ɛ-Ga₂O₃ (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). Mercaptophenylboronic acid-mediated nanozyme immunochromatographic assay for simultaneous detection of respiratory bacteria and virus (Adv. sci. 31/2025). ADVS, 12(31), 71189. (www)

  @article{ , archive = {J_ADVS}, author = {Qing Yu and Jiaxuan Li and Shuai Zheng and Yajin Hu and Benshun Tian and Meirou Lu and Bing Gu and Chongwen Wang}, doi = {10.1002/advs.71189}, journal = {Advanced Science}, month = {8}, number = {31}, pages = {71189}, shortjournal = {Adv. Sci.}, title = {Mercaptophenylboronic acid-mediated nanozyme immunochromatographic assay for simultaneous detection of respiratory bacteria and virus (Adv. sci. 31/2025)}, volume = {12}, year = {2025}, }
• (2025). Facile synthesis of nanolayered manganese oxide for the efficient and selective removal of Strontium(II) from nuclear wastewater. ADVS, 12(30), e17776. (www)

  @article{ , abstract = {Efficient and selective removal of radioactive 90 Strontium ( 90 Sr) from nuclear wastewater is a sustainable strategy for nuclear energy development and environmental protection due to its long half-life and high biochemical toxicity. Herein, a novel nanolayered manganese oxide material (Na 0.7 MnO 2.05 , Na-NLMO) is proposed and its application for Sr(II) capture in both simulated waste liquid and real natural water systems. Na-NLMO is tailored for Sr(II) adsorption through a simple and rapid solid-phase reaction, which has good chemical stability and a strong affinity for Sr(II) across the pH range of 1 to 8. The maximum adsorption capacity is 145.21 mg g −1 taking advantage of the solid-liquid ratio of 0.67 g L −1 . The loaded Sr(II) is almost quantitatively recovered by dilute hydrochloric acid solution. Even after 4 adsorption-desorption cycles, it could still effectively adsorb more than 99.9% of Sr(II). Furthermore, the adsorption is unaffected by the excess presence of sodium(I), potassium(I), magnesium(II), and calcium(II). In real-world media such as tap water and river water, its distribution coefficients are 5.2 × 10 5 and 5.6 × 10 5 mL g −1 , respectively. More importantly, the distribution coefficient toward 90 Sr in seawater still achieved 2.5 × 10 3 mL g −1 . The adsorption mechanism of electrostatic interaction and ion exchange is revealed by combining experimental results and spectroscopic analysis, such as Transmission Electron Microscope and X-ray diffraction. The results are expected to provide new insights into the development of innovative and practical technologies for the treatment and disposal of secondary nuclear waste.}, archive = {J_ADVS}, author = {Fan Wang and Qi Zheng and Wenya Tai and Qiang Wu and Xinglei Li and Yehuizi Wu and Ningchao Zheng and Shunyan Ning and Deqian Zeng and Hiroshi Watabe and Yan Wu and Hai Li and Yuezhou Wei and Xiangbiao Yin}, doi = {10.1002/advs.202417776}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e17776}, shortjournal = {Adv. Sci.}, title = {Facile synthesis of nanolayered manganese oxide for the efficient and selective removal of Strontium(II) from nuclear wastewater}, volume = {12}, year = {2025}, }
• (2025). Comparative analysis of clinical outcomes and financial aspects of phototherapies and immunotherapy for cancer. ADVS, 12(30), e17657. (www)

  @article{ , abstract = {Photo-responsive/activable nanomedicine-driven therapies have emerged as a transformative approach to effectively target and eliminate tumors across different types of solid cancers. When synergistically combined with immunomodulators, these therapies significantly enhance anti-cancer efficacy. This comprehensive review examines the current advancements in photo-responsive/activable immunomodulator-loaded nanomedicines (PINs), providing a detailed analysis of their preclinical development, clinical translation, and associated research funding. The diverse PINs are systematically categorized, innovative design strategies are explored, and the underlying photo-responsive/activable and immunomodulatory mechanisms are elucidated. By integrating clinical advancements with technical innovations and financial perspectives, this review bridges the translational gap, underscoring the immense potential of PINs to revolutionize cancer therapy. This comprehensive resource is indispensable for researchers striving to bring phototherapies to clinical fruition in the battle against cancer.}, archive = {J_ADVS}, author = {Deepak S. Chauhan and Kun Shao and Roopa Hebbandi Nanjundappa and Daniel-Jiajun Yu and Marianne Stanford and Huile Gao and Channakeshava Sokke Umeshappa}, doi = {10.1002/advs.202417657}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e17657}, shortjournal = {Adv. Sci.}, title = {Comparative analysis of clinical outcomes and financial aspects of phototherapies and immunotherapy for cancer}, volume = {12}, year = {2025}, }
• (2025). Heterointerface-modulated synthetic synapses exhibiting complex multiscale plasticity. ADVS, 12(30), e17237. (www)

  @article{ , abstract = {An asymmetric dual-gate heterointerface-regulated artificial synapse (HRAS) is developed, utilizing a main gate with distinct ion concentrations and a lateral gate to receive synaptic pulses, and through dielectric coupling and ionic effects, formed indium tin zinc oxide (ITZO) dual-interface channels that allow precise control over channel charge, thereby simulating multi-level coordinated actions of dual-neurotransmitters. The lateral modulation of the lateral gate significantly regulates ionic effects, achieving the intricate interplay among lateral inhibition/enhancement and short-/long-term plasticity at a multi-level scale for the first time. This interplay enables the HRAS device to simulate frequency-dependent image filtering and spike number-dependent dynamic visual persistence. By combining temporal synaptic inputs with lateral modulation, HRAS harnesses spatiotemporal properties for bio-inspired cryptographic applications, offering a versatile device-level platform for secure information processing. Furthermore, a novel dual-gate input neural network architecture based on HRAS has been proposed, which aids in weight update and demonstrates enhanced recognition capabilities in neural network tasks, highlighting its role in bio-inspired computing.}, archive = {J_ADVS}, author = {Xingji Liu and Yao Ni and Zujun Wang and Sunfu Wei and Xiao′en Chen and Jingjie Lin and Lu Liu and Boyang Yu and Yue Yu and Dengyun Lei and Yayi Chen and Jianfeng Zhang and Jing Qi and Wei Zhong and Yuan Liu}, doi = {10.1002/advs.202417237}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e17237}, shortjournal = {Adv. Sci.}, title = {Heterointerface-modulated synthetic synapses exhibiting complex multiscale plasticity}, volume = {12}, year = {2025}, }
• (2025). From code to life: The AI-driven revolution in genome editing. ADVS, 12(30), e17029. (www)

  @article{ , abstract = {Genome editing has revolutionized modern biotechnology, enabling precise modifications to DNA sequences with far-reaching applications in medicine, agriculture, and synthetic biology. Recent advancements in artificial intelligence (AI) have significantly enhanced genome editing by improving target selection, minimizing off-target effects, and optimizing CRISPR-associated systems. AI-driven models, such as deep learning-based predictors and protein language models, enable more accurate sgRNA design, novel Cas protein discovery, and enhanced gene regulatory network analysis. Additionally, AI-powered tools facilitate large-scale data integration, accelerating functional genomics and therapeutic genome editing. This review explores the intersection of AI and genome editing, highlighting key innovations, challenges, and future prospects. Despite its transformative potential, AI-driven genome editing raises ethical concerns regarding data bias, algorithmic transparency, and unintended genetic modifications. Addressing these challenges requires interdisciplinary collaboration between AI researchers, molecular biologists, and policymakers. As AI continues to evolve, its integration with genome editing will pave the way for groundbreaking advancements in precision medicine, genetic disease treatment, and sustainable agriculture.}, archive = {J_ADVS}, author = {Zhidong Li and Wasi Ullah Khan and Genxiang Bai and Chao Dong and Jungang Wang and Youpeng Zhang and Chong Wang and Hongbin Zhang and Wenyi Wang and Ming Luo and Fei Chen}, doi = {10.1002/advs.202417029}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e17029}, shortjournal = {Adv. Sci.}, title = {From code to life: The AI-driven revolution in genome editing}, volume = {12}, year = {2025}, }
• (2025). Microporous polymer membranes: Molecular stents enhanced solvent-accessibility for organic solvent transport. ADVS, 12(30), e16748. (www)

  @article{ , abstract = {Microporous polymer membranes with high solvent permeability are pivotal for upgrading molecular separations in organic solvents, but this remains challenging due to numerous sub-0.4 nm ultra-micropores resulting from local tight packing, which limit solvent-accessibility. Herein, a microporous polyimide with high intrinsic free volume [PI-TB-NDI, naphthalenediimide (NDI) and Tröger's base (TB)] is synthesized for organic solvent nanofiltration. The resulting polymer showed high free volume because of fused aromatic rings and a twisted structure. Aromatic rings enhanced solvent resistance due to strong molecular interaction, but increased detrimental local tight packing as well. To suppress local tight packing without compromising the molecular interactions vital for stability, an ortho -methyl group is deliberately introduced onto the TB unit to increase both intra- and inter-molecular steric hindrance, imparting an H-shaped TB-NDI-TB molecular stent. On the introduction of ortho -methyl groups, the sub-0.4 nm ultra-micropores are enlarged to ultra-micropores (0.6–0.7 nm) to give the membrane with rich solvent-accessible sub-nanochannels. This resulted in an unprecedented enhancement of solvent permeability, with ethanol permeability 2-8 times greater than that of state-of-the-art polymer membranes with similar selectivity. These findings advance the design strategy of microporous membranes with well-tailored free volume without post-treatments, enabling upscaling and efficient separation of precious species in organic solvents.}, archive = {J_ADVS}, author = {Shuang Guo and Chuanjie Fang and Jiaqi Li and Xiaohe Wang and Weilin Feng and Hukang Guo and Ming Xie and Yongbing Zhuang and Young Moo Lee and Liping Zhu}, doi = {10.1002/advs.202416748}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e16748}, shortjournal = {Adv. Sci.}, title = {Microporous polymer membranes: Molecular stents enhanced solvent-accessibility for organic solvent transport}, volume = {12}, year = {2025}, }
• (2025). Ultrasound-induced nitric oxide-propelled nanomotor for multimodal theranostics of cancer with deep penetration and extended lifetime. ADVS, 12(30), e16709. (www)

  @article{ , abstract = {Cancer treatment is often ineffective due to poor bioimaging and resistance to standard therapies. This issue is exacerbated by multiple low-penetrable bio-barriers that limit the theranostic agents’ effectiveness in tumors. Here, a hollow nanomotor PM-HMSN/Arg is fabricated by a sequential process involving: electrostatic adsorption of Mn 2+ , loading of l -Arg, and coating of platelet membrane (PM), respectively. This nanomotor uses l -Arg as an NO donor and ultrasound (US) as a trigger for NO release. After administration, it improves tumor penetration via a “tethering-relaxing-drilling” mechanism, overcoming bio-barriers during delivery from blood vessels to tumor cells. NO regulates the metabolism of tumor vascular endothelial cells, facilitating relaxation, and enhances cytotoxicity by participating in reactive oxygen species metabolism. More importantly, the nanomotor's active motion enhances tissue penetration and retention in cancer, increasing therapeutic effects. In addition, continuous in situ NO generation extends US imaging signal lifetime. This innovative nanomotor shows promise for multimodal theranostics in low-penetrable tumors.}, archive = {J_ADVS}, author = {Xue Xu and Jinxu Cao and Yan Mu and Hao Zhang and Ya-Lei Wang and Mengzhen Chen and Yuce Li and Qian Hua}, doi = {10.1002/advs.202416709}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e16709}, shortjournal = {Adv. Sci.}, title = {Ultrasound-induced nitric oxide-propelled nanomotor for multimodal theranostics of cancer with deep penetration and extended lifetime}, volume = {12}, year = {2025}, }
• (2025). Comprehensive characterization of bihormonal cells and endocrine cell lineages in mammalian pancreatic islets. ADVS, 12(30), e16326. (www)

  @article{ , abstract = {Understanding the role and prevalence of bihormonal cells in pancreatic islets and their potential in β-cell restoration is critical but remains ambiguous. Using genetically engineered mouse strains with specific fluorescent markers and advanced imaging flow cytometry, it is found that bihormonal cells are exceedingly rare. Single-cell RNA sequencing reveals that Gcg + Ppy + and Gcg + Ins + bihormonal cells closely resemble α-cells or PP-cells and α-cells, respectively, indicating they are neither unique lineages nor transitional states. Dual-recombinase lineage tracing further demonstrates that embryonic Gcg + Ins + cells resolve into monohormonal α-cells. Applying these insights, the scarcity of bihormonal cells in diabetic mouse models is confirmed, suggesting a limited role in β-cell regeneration. By excluding bihormonal influences, endocrine cell classification is redefined in mouse and human islets through gene coexpression network analysis, identifying distinct subtypes and regulatory modules while uncovering species-specific differences. Additionally, two unique δ-cell subpopulations are identified in human islets. Collectively, this study provides a comprehensive characterization of bihormonal cells, refines endocrine cell taxonomy, and underscores the translational challenges in modeling human islet biology in mice.}, archive = {J_ADVS}, author = {Xin-Xin Yu and Peng Peng and Yi-Ning Wang and Mao-Yang He and Shuang He and Chen-Tao Jin and Liu Yang and Xi Wang and Jia-Xi Zheng and Jie Gao and Cheng-Ran Xu}, doi = {10.1002/advs.202416326}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e16326}, shortjournal = {Adv. Sci.}, title = {Comprehensive characterization of bihormonal cells and endocrine cell lineages in mammalian pancreatic islets}, volume = {12}, year = {2025}, }
• (2025). CircTP53/USP10/p53 signaling axis as a novel regulator of progression and prognosis of head and neck squamous cell carcinoma. ADVS, 12(30), e14961. (www)

  @article{ , abstract = {Due to the absence of effective biomarkers, the precision therapy of head and neck squamous cell carcinoma (HNSCC) still faces challenge. TP53 is one of the most frequently mutated genes in human cancers including HNSCC. Although studies on the regulation of TP53 gene and p53 protein have been extensively explored, the association of TP53-derived circRNAs with HNSCC progression, along with their regulatory mechanisms, remains unknown. This study identifies a novel circRNA derived from TP53 (circTP53), which is upregulated in HNSCC and associated with poor prognosis. It is demonstrated that circTP53 promotes HNSCC progression in vitro and in vivo. Mechanistically, circTP53 interacts with the deubiquitinase USP10, leading to their mutual stabilization, which enhances USP10's deubiquitinating activity on p53, thereby stabilizing p53. Interaction analysis reveals that intron 9 of circTP53 interacts with 100–399AA of USP10. In tumor cells with wild-type p53, circTP53 suppresses cell viability and inhibits the growth of xenograft tumors, while in tumor cells harboring mutant p53, circTP53 demonstrates the opposite effect, enhancing cell viability and promoting xenograft tumor progression. The identification of circTP53 suggests a new direction for p53 research, and the elucidation of circTP53/USP10/p53 axis may provide a new therapeutic scheme for future precision treatment of HNSCC.}, archive = {J_ADVS}, author = {Yin Wang and Fen Chang and Zinan Li and Chengcheng Duan and Xiangkai Sun and Siyu Wang and Dongmin Wei and Wenming Li and Ye Qian and Shengda Cao and Juan Zhao and Dapeng Lei}, doi = {10.1002/advs.202414961}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e14961}, shortjournal = {Adv. Sci.}, title = {CircTP53/USP10/p53 signaling axis as a novel regulator of progression and prognosis of head and neck squamous cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Engineering electron transfer flux between cytochrome p450 enzyme and p450 reductase to enhance serotonin production in escherichia coli. ADVS, 12(30), e14859. (www)

  @article{ , abstract = {Microbial cell factories produce valuable compounds by exploiting cytochrome P450 catalytic systems. However, the inefficient electron transfer flux (ETF) between P450 and cytochrome P450 reductase (CPR) hinders the efficient synthesis of natural products. Herein, an ETF is systematically engineered by regulating the electron transfer rate, electron-receiving rate, and electron donor NADPH availability for serotonin production. First, a putative electron transfer pathway (ETP) is identified using virtual computing and evolved based on a genetically encoded serotonin RNA biosensor. Subsequently, an intermediate site strategy is developed to shorten the electron-hopping steps and distance in the ETP of CPR for enhancing the electron transfer rate. Next, the heme-binding domain is engineered to reduce the distance between heme-Fe and the substrate channel terminal in T5H for improving the electron-receiving rate. Furthermore, the NADPH pool is enlarged to increase the electron supply for efficient catalysis of P450 systems. Finally, tryptophan-5-hydroxylase (T5H) activity ( K cat /K M ) in the optimal mutant is 36.62-fold than that of wild-type. The engineered strain E. coli S11 can produce 15.42 g L −1 serotonin in a 7.5-L bioreactor, which is 9.17-fold of the previous reported. This strategy provides a systematic approach for regulating ETF in complex P450 catalytic systems for efficient chemical biosynthesis.}, archive = {J_ADVS}, author = {Wenzhao Xu and Pengling Wei and Lirong Chen and Ling Gao and Xiaole Xia}, doi = {10.1002/advs.202414859}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e14859}, shortjournal = {Adv. Sci.}, title = {Engineering electron transfer flux between cytochrome p450 enzyme and p450 reductase to enhance serotonin production in escherichia coli}, volume = {12}, year = {2025}, }
• (2025). PiR-RCC suppresses renal cell carcinoma progression by facilitating YBX-1 cytoplasm localization. ADVS, 12(30), e14398. (www)

  @article{ , abstract = {PIWI-interacting RNAs (piRNAs), a novel category of small non-coding RNAs, are widely expressed in eukaryotes and deregulated in several pathologies, including cancer. Little is known about their function and mechanism in renal cell carcinoma (RCC) progression. Herein, a down-regulated piRNA in RCC, termed piR-hsa-28489 (designated as piR-RCC), is identified to impede RCC progression both in vivo and in vitro. Mechanistically, piR-RCC directly interacts with Y-box binding protein 1 (YBX-1), thus impeding p-AKT-mediated YBX-1 phosphorylation and its subsequent nuclear translocation. Moreover, YBX-1 coordinates the transcription of ETS homologous factor (EHF) as a repressor factor. Consequently, piR-RCC enhances EHF expression, leading to the inhibition of RCC proliferation and metastasis. Based on these, a biomimetic nanoparticle platform is constructed to achieve RCC-specific targeted delivery of piR-RCC. The nanoparticles are fabricated using a cell membrane coating derived from cancer cells and used to encapsulate and deliver piR-RCC plasmids to renal orthotopic implantation in mice, hindering RCC progression. This study illustrates piR-RCC/YBX-1/EHF signaling axis in RCC, offering a promising therapeutic avenue for RCC.}, archive = {J_ADVS}, author = {Ruyue Wang and Fan Li and Yudong Lin and Zeyi Lu and Wenqin Luo and Zhehao Xu and Ziwei Zhu and Yi Lu and Xudong Mao and Yang Li and Zhinian Shen and Haohua Lu and Yining Chen and Liqun Xia and Mingchao Wang and Lifeng Ding and Gonghui Li}, doi = {10.1002/advs.202414398}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e14398}, shortjournal = {Adv. Sci.}, title = {PiR-RCC suppresses renal cell carcinoma progression by facilitating YBX-1 cytoplasm localization}, volume = {12}, year = {2025}, }
• (2025). PROS1-MERTK axis drives tumor microenvironment crosstalk and progression in papillary thyroid microcarcinoma. ADVS, 12(30), e13474. (www)

  @article{ , abstract = {The incidence of papillary thyroid carcinoma (PTC) has been rising annually, with papillary thyroid microcarcinoma (PTMC) accounting for more than half of the cases. While most PTMCs exhibit indolent growth and a favorable prognosis, some undergo clinical progression with poor outcomes. Thus, identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single-cell RNA sequencing on 19 surgical tissue specimens from 15 patients, including four para-tumor tissues, four non-progressive PTMCs, five progressive PTMCs, and six progressive PTCs. Key findings are corroborated through in vivo and in vitro experiments. Single-cell RNA sequencing and spatial transcriptomics characterized the cellular ecosystem within PTC, revealing multi-directional evolutionary patterns as PTMC progresses. Analysis of progression-specific alterations in intercellular communication networks highlighted the PROS1-MERTK signaling interaction as pivotal in PTMC progression. In vitro and in vivo models confirm that the PROS1-MERTK axis accelerates PTMC progression via paracrine and autocrine signaling. Furthermore, NFYB and FOXP2 are identified as activators of PROS1 transcription in fibroblasts, promoting PTMC progression through the MERTK/WNT/TGF-β signaling. These findings underscore the PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism in PTMC progression.}, archive = {J_ADVS}, author = {Wenqian Zhang and Ye Zhang and Zhu Liu and Zhiyuan Wang and Huaqin Wang and Xiaoyu Ji and Hongyue Su and Fan Yang and Lirong Yan and Ying Xu and Hao Zhang and Wei Sun}, doi = {10.1002/advs.202413474}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e13474}, shortjournal = {Adv. Sci.}, title = {PROS1-MERTK axis drives tumor microenvironment crosstalk and progression in papillary thyroid microcarcinoma}, volume = {12}, year = {2025}, }
• (2025). Reply to “Exploring bacteria-based cancer Immunotherapy”—Comment on “Discovery of intratumoral oncolytic bacteria toward targeted anticancer theranostics”. ADVS, 12(30), e11325. (www)

  @article{ , abstract = {This manuscript is a formal response to the commentary by A/Prof. Dr. Chen-xi Li and colleagues regarding our previous publication in Advanced Science. We clarify the rationale, methods, and outcomes of our original study and highlight ongoing work in the field of bacterial cancer immunotherapy.}, archive = {J_ADVS}, author = {Eijiro Miyako}, doi = {10.1002/advs.202511325}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e11325}, shortjournal = {Adv. Sci.}, title = {Reply to “Exploring bacteria-based cancer Immunotherapy”—Comment on “Discovery of intratumoral oncolytic bacteria toward targeted anticancer theranostics”}, volume = {12}, year = {2025}, }
• (2025). EGR1 promotes craniofacial bone regeneration via activation of ALPL⁺PDGFD⁺ periosteal stem cells. ADVS, 12(30), e10243. (www)

  @article{ , abstract = {Oral and craniofacial bone regeneration remains challenging due to unique anatomical and functional demands. Rodent models have limited translational value because of significant structural differences from humans. The study reveals high similarity in calvarial periosteal cell composition between miniature pigs and humans at single-cell resolution. ALPL + PDGFD + (AP + ) cells are identified as distinct calvarial periosteal stem cells (PeSCs) that possess self-renewal and differentiation potential in both swine and human calvarial periosteum. Postnatally, AP + PeSCs exhibit reduced activity compared to their embryonic counterparts, with EGR1 recognized as a crucial factor for their activation. Upon activation, these cells effectively facilitate the repair of craniofacial bone injuries. EGR1 regulates PeSCs development by modulating BMP signaling through its Znf2 domain and activating these cells via the CTNNB1/WNT10B pathway through its Znf2/3 domains in response to injury. The validation of the findings using human cranial periosteal samples from various developmental stages (embryonic and adult) further supports the results obtained from large animal experiments, providing a solid scientific foundation for the clinical application of AP + cranial periosteal stem cells. Additionally, targeting specific EGR1 domains for in situ activation of PeSCs offers a promising strategy for enhancing bone regeneration.}, archive = {J_ADVS}, author = {Yang Li and Dazhuang Lu and Fanqing Xu and Jun Yang and Dong Li and Chenlong Yang and Xin Chen and Xu Wang and Jia Qing and Hui Zhang and Yingfei Zhang and Fuchou Tang and Jie Qiao and Ophir D. Klein and Ping Zhang and Yongsheng Zhou}, doi = {10.1002/advs.202410243}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e10243}, shortjournal = {Adv. Sci.}, title = {EGR1 promotes craniofacial bone regeneration via activation of ALPL⁺PDGFD⁺ periosteal stem cells}, volume = {12}, year = {2025}, }
• (2025). Correction to “Sequential targeting chondroitin sulfate-bilirubin nanomedicine attenuates osteoarthritis via reprogramming lipid metabolism in m1 macrophages”. ADVS, 12(30), e07227. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202507227}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e07227}, shortjournal = {Adv. Sci.}, title = {Correction to “Sequential targeting chondroitin sulfate-bilirubin nanomedicine attenuates osteoarthritis via reprogramming lipid metabolism in m1 macrophages”}, volume = {12}, year = {2025}, }
• (2025). Structure and ionic conductivity of halide solid electrolytes based on NaAlCl4 and Na2ZnCl4. ADVS, 12(30), e07224. (www)

  @article{ , abstract = {Sodium-based solid-state batteries may represent safe and cost-effective energy storage devices, complementing Li-ion for specific applications such as grid storage. Thus, sustainable solid-state electrolytes (SSE) with high ionic conductivity need to be developed. Sodium metal halide SSEs have attracted significant attention due to their ionic conductivity, electrochemical stability, and adequate processibility. Here, SSE based on NaAlCl 4 (NAC) and Na 2 ZnCl 4 (NZC) are investigated, nominally Na 1+ x Zn x Al 1− x Cl₄. Compounds synthesized by ball-milling and investigated by X-ray diffraction revealed a two-phase system, with a solid solution in the Na 2 ZnCl 4 -type structure extending to ≈34(3)% Al substitution. EIS results demonstrate the highest ionic conductivity is near the miscibility gap edge (x = 0.625), where σ is increased by several orders of magnitude as compared to NZC and reaches 1.5×10⁻ 5 S cm −1 at 25 °C, above the values of Na 2 ZnCl 4 /NaAlCl 4 . The combined use of molecular dynamics simulations and nuclear magnetic resonance distinctly elucidates the importance of achieving enough Na⁺ vacancies in both Na sublattices in NZC-type structures. This work introduces a novel class of SSE based on the NZC olivine structure, demonstrates that they can be used as catholytes to assemble working solid-state sodium batteries, and provides insights into the correlation between composition, crystalline structure, and ionic conduction pathways.}, archive = {J_ADVS}, author = {Hao Guo and Michael Häfner and Helen Grüninger and Matteo Bianchini}, doi = {10.1002/advs.202507224}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e07224}, shortjournal = {Adv. Sci.}, title = {Structure and ionic conductivity of halide solid electrolytes based on NaAlCl4 and Na2ZnCl4}, volume = {12}, year = {2025}, }
• (2025). A pump-free, hydraulic-amplification oscillatory microfluidic device for continuous particle and cell manipulation. ADVS, 12(30), e07041. (www)

  @article{ , abstract = {Microfluidics can achieve the spatiotemporal manipulation of particles and cells in the microscale fluids, but highly relies on the accuracy of the pumping systems. To overcome this issue, a pump-free, hydraulic-amplification oscillatory microfluidic (PHOMF) device is presented, which can be actuated by fingers to handle particles and cells within the microchannel. The PHOMF device has a hydraulic-amplification module for pressure transfer and a soft microchannel module for the generation of oscillatory flows. This is made possible by the periodic transfer of finger-driven liquid pressure to the soft microchannel. This pressure causes the soft microchannel to deform and then drives the reciprocating flow of fluid volumes within the microchannel. In the oscillatory flow, particles and cells achieve single-line focusing driven by the spatially accumulated inertial and elastic lift forces. The particle elasto-inertial focusing theory in the PHOMF microchannel has been revealed. To demonstrate the system's practicality, the PHOMF device is utilized to achieve the early observation of platelet clots (3 min) and the rapid staining of cancer cells (8 min). The PHOMF device provides a miniaturized, inexpensive, and efficient detection tool for lab-on-a-chip, and has the potential to become a mass-produced, widely available, and convenient disease detection product.}, archive = {J_ADVS}, author = {Yong Liu and Mingyi Liang and Shanshan Xu and Sheng Yan}, doi = {10.1002/advs.202507041}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e07041}, shortjournal = {Adv. Sci.}, title = {A pump-free, hydraulic-amplification oscillatory microfluidic device for continuous particle and cell manipulation}, volume = {12}, year = {2025}, }
• (2025). Non-invasive diagnosis of chronic myocardial infarction via composite in-silico-human data learning. ADVS, 12(30), e06933. (www)

  @article{ , abstract = {Myocardial infarction (MI) continues to be a leading cause of death worldwide. The precise quantification of infarcted tissue is crucial to diagnosis, therapeutic management, and post-MI care. Late gadolinium enhancement-cardiac magnetic resonance (LGE-CMR) is regarded as the gold standard for precise infarct tissue localization in MI patients. A fundamental limitation of LGE-CMR is the invasive intravenous introduction of gadolinium-based contrast agents that present potential high-risk toxicity, particularly for individuals with underlying chronic kidney diseases. Herein, a completely non-invasive methodology is developed to identify the location and extent of an infarct region in the left ventricle via a machine learning (ML) model using only cardiac strains as inputs. In this approach, the remarkable performance of a multi-fidelity ML model is demonstrated, which combines rodent-based in-silico-generated training data (low-fidelity) with very limited patient-specific human data (high-fidelity) in predicting LGE ground truth. The results offer a new paradigm for developing feasible prognostic tools by augmenting synthetic simulation-based data with very small amounts of in vivo human data. More broadly, the proposed approach can significantly assist with addressing biomedical challenges in healthcare where human data are limited.}, archive = {J_ADVS}, author = {Rana Raza Mehdi and Nikhil Kadivar and Tanmay Mukherjee and Emilio A. Mendiola and Akila Bersali and Dipan J. Shah and George Karniadakis and Reza Avazmohammadi}, doi = {10.1002/advs.202406933}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e06933}, shortjournal = {Adv. Sci.}, title = {Non-invasive diagnosis of chronic myocardial infarction via composite in-silico-human data learning}, volume = {12}, year = {2025}, }
• (2025). Exploring bacteria-based cancer immunotherapy: Comment on “Discovery of intratumoral oncolytic bacteria toward targeted anticancer theranostics”. ADVS, 12(30), e06869. (www)

  @article{ , archive = {J_ADVS}, author = {Chen-xi Li and Zhong-cheng Gong}, doi = {10.1002/advs.202506869}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e06869}, shortjournal = {Adv. Sci.}, title = {Exploring bacteria-based cancer immunotherapy: Comment on “Discovery of intratumoral oncolytic bacteria toward targeted anticancer theranostics”}, volume = {12}, year = {2025}, }
• (2025). Corrigendum to “YWHAG deficiency disrupts the EMT-associated network to induce oxidative cell death and prevent metastasis”. ADVS, 12(30), e06464. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202506464}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e06464}, shortjournal = {Adv. Sci.}, title = {Corrigendum to “YWHAG deficiency disrupts the EMT-associated network to induce oxidative cell death and prevent metastasis”}, volume = {12}, year = {2025}, }
• (2025). Impact of virus-mediated modifications in bacterial communities on the accumulation of soil organic carbon. ADVS, 12(30), e06449. (www)

  @article{ , abstract = {Microbial adaptations to resource availability are crucial to predict the responses of ecosystems to carbon (C) changes, yet viral roles in C cycling under varying levels of C remain elusive. Through metagenomic analysis of soils with contrasting C availability, a total of 24,789 viral contigs predominantly represent Microviridae and Siphoviridae . The soils with low C availability (straw removal) harbored 21% lysogenic viruses and enriched auxiliary metabolic genes (AMGs) related to C degradation ( p < 0.05). Conversely, the soils with high C availability (straw returning) show 93% lytic viruses, stronger virus-bacteria symbiosis, and numerous host functional genes related to C cycling and viral AMGs linked to C fixation ( p < 0.05). Furthermore, these findings show that the addition of viruses boosted microbial metabolic efficiency and recalcitrant C accumulation ( p < 0.05), with lytic activity accelerating organic C turnover via nutrient release and necromass formation. Overall, this study demonstrates viruses as key regulators of sustainable sequestration of C through host-driven metabolic optimization.}, archive = {J_ADVS}, author = {Mingfeng Liu and Guixiang Zhou and Congzhi Zhang and Lin Chen and Donghao Ma and Lijun Zhang and Chunhua Jia and Ling Ma and Jiabao Zhang}, doi = {10.1002/advs.202506449}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e06449}, shortjournal = {Adv. Sci.}, title = {Impact of virus-mediated modifications in bacterial communities on the accumulation of soil organic carbon}, volume = {12}, year = {2025}, }
• (2025). Natural Fiber@MXene-engineered chitosan aerogels: Thermodynamic-transport synergy for solar-driven hypersaline interfacial evaporation. ADVS, 12(30), e05944. (www)

  @article{ , abstract = {Enhancing interfacial evaporation rates and optimizing energy utilization remain critical challenges in solar-driven steam generation. Natural fiber@MXene-engineered chitosan aerogels with hierarchically oriented channels to achieve high-efficiency solar-driven steam generation are developed. The kapok fiber@MXene core–shell units (MKFs) construct photon-entrapping topological networks that enhance light absorption while simultaneously reinforcing the aerogel's structural integrity and durability for practical applications. The aerogel's oriented microchannels establish thermodynamic potential gradients, facilitating spontaneous capillary-driven water replenishment and environmental thermal harvesting. Both experimental results and COMSOL multiphysics simulations systematically demonstrate that hierarchical pore channels enhance water transport, improve solar-thermal/environmental energy synergy, and promote the downward diffusion of concentrated ions from the evaporation surface, achieving an evaporation rate up to 4.40 kg m −2 h −1 with efficient salt rejection. Long-term outdoor tests with various corrosive wastewater solutions further validate the aerogel's durability in solar-driven interfacial evaporation. This study provides a theoretical foundation for understanding the interrelation between solar energy absorption, water transport, and salt diffusion in aerogel evaporators with hierarchical fiber-pore architectures.}, archive = {J_ADVS}, author = {Qin Su and Haidi Wu and Suyang Hou and Liping Ye and Yifan Feng and Longjuan Lu and Biwang Pan and Wancheng Gu and Longcheng Tang and Xuewu Huang and Huaiguo Xue and Jiefeng Gao}, doi = {10.1002/advs.202505944}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e05944}, shortjournal = {Adv. Sci.}, title = {Natural Fiber@MXene-engineered chitosan aerogels: Thermodynamic-transport synergy for solar-driven hypersaline interfacial evaporation}, volume = {12}, year = {2025}, }
• (2025). Rational molecular engineering of amidonaphthoquinone cathodes: Precise hydrogen bond and size control for high-performance lithium organic batteries. ADVS, 12(30), e05936. (www)

  @article{ , abstract = {Rational design of organic cathode materials with suppressed solubility is crucial yet challenging for achieving high-capacity and long-cycling rechargeable batteries. This study presents a facile synthesis strategy for three naphthoquinone derivatives (NQ1-NQ3) featuring tunable amide functionalities and molecular dimensions, followed by a systematic evaluation of their electrochemical performance in lithium-organic batteries (LOBs). The strategic incorporation of multiple amide motifs and molecular size expansion in NQ2 and NQ3 effectively enhances intermolecular interactions through hydrogen-bonding networks and π–π stacking, resulting in remarkable solubility suppression and superior cycling stability. Notably, the NQ3-based cathode demonstrates an intriguing structural evolution involving progressive particle pulverization during cycling, which facilitates intimate contact with conductive carbon additives and significantly improves electrode conductivity. These synergistic effects enable the best LOB performance of NQ3, such as a high specific capacity (224 mAh g −1 at 0.1 A g −1 ), good rate capability (162 mAh g −1 at 2 A g −1 ) and cycling stability, outperforming most reported organic cathode materials. This work provides molecular-level insights into suppressing dissolution through non-covalent interaction engineering for high performance LOBs.}, archive = {J_ADVS}, author = {Qianglong Chen and Fangfang Xing and Jia Cai and Xiujuan Wang and Xiaoming He}, doi = {10.1002/advs.202505936}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e05936}, shortjournal = {Adv. Sci.}, title = {Rational molecular engineering of amidonaphthoquinone cathodes: Precise hydrogen bond and size control for high-performance lithium organic batteries}, volume = {12}, year = {2025}, }
• (2025). Harnessing work function modulation for hydrogen evolution catalysis in mesoporous bimetallic pt-M alloys: The role of mesopores in work function optimization. ADVS, 12(30), e05464. (www)

  @article{ , abstract = {Work function (WF) influences electron transport and intermediates adsorption, enabling charge balance and catalytic optimization for the hydrogen evolution reaction (HER). However, the understanding of the role of mesopores and the relationship between composition and WF in pristine Pt-based alloys remains lacking. Herein, various mesoporous binary Pt-M alloy films (m-Pt-M, M = Pd, Rh, and Ru) with uniform pores and elemental distributions are synthesized, providing an experimental platform to investigate this relationship. It has been demonstrated that the WFs of m-Pt-M catalysts are strongly influenced by their compositions and mesoporous structures, thereby impacting HER activities. Among them, m-Pt-Ru with tailored WF lowers the thermodynamic energy barrier and accelerates the kinetic processes of HER. The mass activity of m-Pt-Ru in alkaline media is 17.8× and 5.1× higher, compared to Pt black and m-Pt, respectively. This work not only provides a simple method for the fabrication of well-defined binary metallic alloy films but also offers experimental insights into the rational design of highly efficient electrocatalysts with tunable WFs.}, archive = {J_ADVS}, author = {Lei Fu and Yunqing Kang and Ho Ngoc Nam and Kaiteng Wang and Zilin Zhou and Yingji Zhao and Quan Manh Phung and Kai Wu and Yusuke Asakura and Jun Zhou and Yusuke Yamauchi}, doi = {10.1002/advs.202505464}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e05464}, shortjournal = {Adv. Sci.}, title = {Harnessing work function modulation for hydrogen evolution catalysis in mesoporous bimetallic pt-M alloys: The role of mesopores in work function optimization}, volume = {12}, year = {2025}, }
• (2025). Adaptive catalytic nanointerfaces for controlled hydrogen evolution: An in situ electrochemical approach. ADVS, 12(30), e05104. (www)

  @article{ , abstract = {Precious metal nanoparticles in electrocatalytic applications tend to be single-use, becoming unusable afterward. Here, this is demonstrated that the electrocatalytic response of these nanoparticles, when confined at the step-edges of corrugated carbon nanofibers interiors, can be switched on again at will by simply introducing sulfur as an inorganic mediator. To achieve this, an electrochemical methodology is developed that triggers the rapid surface reconfiguration of confined, deactivated nanoparticles (PdS x ) involving the release of sulfur to yield highly active crystalline Pd(0) nanoparticles, confined polysulfides, and sulfur-terminated carbon step-edges. More importantly, the electrochemical performance can be systematically switched from a highly active mode, in which polysulfides enhance the hydrogen adsorption on palladium, to a much less active mode, called the resting mode, in which sulfur (formed by the oxidation of polysulfides) passivates the active Pd(0) nanoparticle surface. This discovery introduces a new protocol to control nanoparticle performance for catalytic reactions, and more crucially, to extend their lifespan.}, archive = {J_ADVS}, author = {Carlos Herreros-Lucas and Melanie Guillén-Soler and Lucía Vizcaíno-Anaya and Glen Murray and Mehtap Aygün and José Manuel Vila-Fungueiriño and María del Carmen Giménez-López}, doi = {10.1002/advs.202505104}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e05104}, shortjournal = {Adv. Sci.}, title = {Adaptive catalytic nanointerfaces for controlled hydrogen evolution: An in situ electrochemical approach}, volume = {12}, year = {2025}, }
• (2025). The immune microenvironment: New therapeutic implications in organ fibrosis. ADVS, 12(30), e05067. (www)

  @article{ , abstract = {Fibrosis, characterized by abnormal deposition of structural proteins, is a major cause of tissue dysfunction in chronic diseases. The disease burden associated with progressive fibrosis is substantial, and currently approved drugs are unable to effectively reverse it. Immune cells are increasingly recognized as crucial regulators in the pathological process of fibrosis by releasing effector molecules, such as cytokines, chemokines, extracellular vesicles, metabolites, proteases, or intercellular contact. Therefore, targeting the immune microenvironment can be a potential strategy for fibrosis reduction and reversion. This review summarizes the recent advances in the understanding of the immune microenvironment in fibrosis including phenotypic and functional transformations of immune cells and the interaction of immune cells with other cells. The novel opportunities for the discovery and development of drugs for immune microenvironment remodeling and their associated challenges are also discussed.}, archive = {J_ADVS}, author = {Xiangqi Chen and Chuan Wu and Fei Tang and Jingyue Zhou and Li Mo and Yanping Li and Jinhan He}, doi = {10.1002/advs.202505067}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e05067}, shortjournal = {Adv. Sci.}, title = {The immune microenvironment: New therapeutic implications in organ fibrosis}, volume = {12}, year = {2025}, }
• (2025). Impact of disorder, porosity, and surface chemistry of salt templated carbons on capacitance. ADVS, 12(30), e05032. (www)

  @article{ , abstract = {The necessity of tailoring the structure/texture of carbons to improve the performance of aqueous-based electrical double-layer capacitors (EDLCs) is emphasized. A green soft-salt templating approach allowed the preparation of a series of porous carbons for this target. The EDLCs operating in 1M Li 2 SO 4 demonstrated a maximum capacitance of 244 F g −1 at 1.6 V (CsCl/KCl-T), long-term cycle life (288 h for LiCl/KCl-T), and a specific energy exceeding 10 Wh kg −1 . The physicochemical properties of carbons have been correlated with capacitance, retention, and stability. The investigation by Raman spectroscopy revealed that carbons with the increased disorder, thus, higher I D /I G ratio, are in accord with enhanced capacitance. Active surface area (ASA) values, related to carbon defects, perfectly supported the Raman findings. Surface functionality, i.e., the phenol/ether and carboxyl groups are found to affect capacitance. The carbons showed a predominance of micropores, with a specific surface area (SSA) ranging from 2640 to 1453 m 2 g −1 . In sum, I D /I G , SSA, ASA, and volume of micropores are in linear proportion with capacitance at various regimes. However, the most ordered and less porous materials provided better lifespan performance. Therefore, a good compromise is required to satisfy both high capacitance and the long cycle life of EDLCs.}, archive = {J_ADVS}, author = {Amelia Klimek and Bénédicte Réty and Camélia Matei Ghimbeu and Elzbieta Frackowiak}, doi = {10.1002/advs.202505032}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e05032}, shortjournal = {Adv. Sci.}, title = {Impact of disorder, porosity, and surface chemistry of salt templated carbons on capacitance}, volume = {12}, year = {2025}, }
• (2025). High-performing clean water production by rational design of functional solar evaporator and vapor condensation. ADVS, 12(30), e05008. (www)

  @article{ , abstract = {Interfacial solar evaporation is a promising technology to address the global issue of water scarcity with a minimum carbon footprint. Although solar-to-vapor conversion efficiency has been significantly improved, it does not actually lead to high clean water production due to low vapor condensation efficiency and water collection rate, which hinders real-world applications. Herein, an invert-structured solar evaporation and vapor condensation device coupled with solar evaporators featuring special vertically aligned vapor diffusion channels is designed to target both high evaporation and water collection rates. Graphene oxides, carbon dots, and MXene are used to construct sophisticated nanostructure to effectively confine the thermal energy in the structure for water evaporation. The vertical channels in the evaporators allow downward vapor transportation for condensation. The bottom condenser, made of highly thermal-conductive materials with hydrophobic coating, is cooled by bulk water underneath, accelerating the dropwise condensation processes. In addition, since vapor is pushed downward, light absorption on the top evaporation surface is not declined. Both top and bottom evaporation surfaces are activated for water evaporation. Therefore, this inverted device achieves a record-high water-collection rate of 2.31 kg m −2 h −1 under one sun, superior to conventional single-stage solar evaporation systems, suggesting great potential in practical seawater desalination.}, archive = {J_ADVS}, author = {Bingxing Wu and Xiangqian Fan and Chaorui Xue and Qing Chang and Jinlong Yang and Shengliang Hu and Haolan Xu}, doi = {10.1002/advs.202505008}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e05008}, shortjournal = {Adv. Sci.}, title = {High-performing clean water production by rational design of functional solar evaporator and vapor condensation}, volume = {12}, year = {2025}, }
• (2025). Cryo-inactivated cancer cells derived magnetic micromotors for tumor immunotherapy. ADVS, 12(30), e04986. (www)

  @article{ , abstract = {Immunotherapy represents a highly promising modality in cancer treatment, with substantial advancements in therapeutic strategies. The primary challenge lies in enhancing the efficacy of immunotherapy approaches. Here, novel cryo-inactivated cancer cells (CICC) derived magnetic micromotors (CICC@FeMnP) are reported for tumor synergistic immunotherapy. Through the magnetic control, the CICC@FeMnP micromotors can on-demand target and accumulate at the tumor site. The FeMnP can induce ferroptosis and then trigger immunogenic cell death of tumor cells. The CICC containing the whole cancer antigen can conduct vaccination effects. Together with the Mn 2+ -mediated cGAS-STING pathway to stimulate the immune response, substantial anti-tumor immune effects can be achieved. Importantly, the CICC@FeMnP micromotors not only facilitate the establishment of a collaborative anti-tumor immune network to enhance effective tumoricidal immunity but also induce long-lasting immune memory effects. These results contribute to the inhibition of tumor progression, recurrence and lung metastasis, thereby prolonging the overall survival of tumor-bearing mice. This work underscores the potential of an engineered biohybrid micromotor system as an alternative therapeutic approach in immunotherapy to enhance efficacy against tumors.}, archive = {J_ADVS}, author = {Qingfei Zhang and Gaizhen Kuang and Wenzhao Li and Yuanjin Zhao}, doi = {10.1002/advs.202504986}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04986}, shortjournal = {Adv. Sci.}, title = {Cryo-inactivated cancer cells derived magnetic micromotors for tumor immunotherapy}, volume = {12}, year = {2025}, }
• (2025). High-throughput MicroED for probing ion channel dynamics. ADVS, 12(30), e04881. (www)

  @article{ , abstract = {Ion channels play a crucial role in ion transport and are integral to fundamental physiological processes. Understanding channel structures is essential for elucidating the mechanisms of ion permeation and selectivity beyond simple computational simulations. Visualizing dynamics at high resolution, however, remains a significant challenge by structural techniques. In this study, high-throughput microcrystal electron diffraction (MicroED) is applied to explore the structural dynamics of two ion channels, the non-selective ion channel NaK and its mutant, NaK2CNG. This approach utilizes automated data collection and processing to capture distinct structural substates from a large number of microcrystals, offering a deeper understanding of ion channel mechanisms. From a subset of NaK structures, consistent sodium binding at specific sites is observed. In contrast, NaK2CNG appears more dynamic and undergoes dilation of the selectivity filter upon potassium binding. Further, the conduction state of NaK2CNG appears to be influenced by channel gating. Comparative analysis of these structures suggests that plasticity of the selectivity filter may contribute to the non-selectivity of these channels, potentially allowing dynamic control over ion passage. These studies demonstrate the potential to employ high-throughput MicroED as a technique to address persistent questions regarding ion channel permeation, complementing current computational molecular dynamics studies.}, archive = {J_ADVS}, author = {Marc J Gallenito and Max TB Clabbers and Jieye Lin and Johan Hattne and Tamir Gonen}, doi = {10.1002/advs.202504881}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04881}, shortjournal = {Adv. Sci.}, title = {High-throughput MicroED for probing ion channel dynamics}, volume = {12}, year = {2025}, }
• (2025). Highly oriented bio-mimetic hydrogels by calendering. ADVS, 12(30), e04778. (www)

  @article{ , abstract = {Anisotropic hydrogels are promising candidates as load-bearing materials for tissue engineering, while huge challenges remain in exploring effective and scalable methods for the preparation of anisotropic hydrogels with simultaneous high tensile strength, large toughness, good fracture strain, excellent fatigue and swelling resistances. Inspired by the brick-and-mortar layered structure of nacre and the hierarchical fibril strucure of soft tissues (e.g., tendon and ligament), a facile organogel-assissted calendering strategy is reported to design anisotropic hydrogels with a highly oriented and dense fiber lamellar strucure. The synergy of shearing and annealing promotes macromolecular chain alignment and crystallinity along the calendering direction while forming a nacre-like lamellar morphology in the thickness direction. The tensile strength, elastic modulus, toughness and fracture energy of the anisotropic hydrogels can reach as high as 41.0 ± 6.4 MPa, 67.0 ± 5.1 MPa, 46.2 ± 3.3 MJ m −3 , and 62.20 ± 8.55 kJ m −2 , respectively. More importantly, the hydrogels show excellent crack growth and swelling resistances with the fatigue threshold increased to 2170 J m −2 . This study provides a promising approach for fabrication of large-sized biomimetic anisotropic hydrogels with outstanding mechanical properties for biomedical and engineering applications.}, archive = {J_ADVS}, author = {Zhanqi Liu and Yuqing Wang and Haidi Wu and Huamin Li and Longcheng Tang and Guo Wang and Daxin Zhang and Jianping Yin and Yinggang Miao and Yongqian Shi and Pingan Song and An Xie and Xuewu Huang and Wancheng Gu and Yiu Wing Mai and Jiefeng Gao}, doi = {10.1002/advs.202504778}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04778}, shortjournal = {Adv. Sci.}, title = {Highly oriented bio-mimetic hydrogels by calendering}, volume = {12}, year = {2025}, }
• (2025). Determination of the experimental minimal formula of metal-organic frameworks. ADVS, 12(30), e04713. (www)

  @article{ , abstract = {The determination of the precise chemical composition of metal organic frameworks (MOFs) is often overlooked, although it is crucial for many advanced applications such as catalysis or drug delivery. Here, a rigorous yet simple method is proposed for the accurate determination of a MOF's minimal formula. By combining quantitative nuclear magnetic resonance (NMR) and ultraviolet-visible (UV–vis) spectroscopy data with thermogravimetric analysis (TGA), the minimal formula of several MOFs – MOF-808(Zr), UiO-66(Zr), UiO-66(Ce), MOF-5(Zn), MIL-125(Ti), and MIL-100(Fe) – are constructed. The influence of the MOF digestion method and the NMR measurement parameters on the accuracy of the minimal formula is shown. A quantitative method is provided for determining the amount of residual chloride or nitrate from metal precursors used in MOF synthesis, which has been ignored so far in minimal formulae determination. To improve the reproducibility and accuracy of MOF applications, the concept of the experimental molar mass is introduced, which can deviate significantly from the idealized molar mass. Although the determination of the MOF experimental minimal formula is often perceived as a complex and tedious task, the general methodology presented here is straightforward and involves very simple equations and procedures. It is easily generalized to new MOFs and even coordination networks of unknown structure, as demonstrated here for Al-BDC.}, archive = {J_ADVS}, author = {Jikson Pulparayil Mathew and Charlotte Simms and David E. Salazar Marcano and Evert Dhaene and Tatjana N. Parac-Vogt and Jonathan De Roo}, doi = {10.1002/advs.202504713}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04713}, shortjournal = {Adv. Sci.}, title = {Determination of the experimental minimal formula of metal-organic frameworks}, volume = {12}, year = {2025}, }
• (2025). Expansion force-based adaptive multistage constant current fast charging with lithium plating detection for lithium-ion batteries. ADVS, 12(30), e04580. (www)

  @article{ , abstract = {The multistage constant current (MCC) charging protocol for lithium-ion batteries is commonly used to balance lithium plating and charging time. Traditional methods depend on a pre-defined charging map without considering the feedback of lithium plating and subsequent self-regulation of the charging rate. To tackle this problem, an adaptive MCC charging method is proposed, which is based on expansion force feedback to detect lithium plating. By integrating experiments with simulations, the results indicate that when lithium plating occurs, the force experiences an abnormal, accelerated increase. If the charging rate is reduced until lithium plating ceases, the force decreases. Correspondingly, three thresholds, V1, V2, and V3, in the derivative of force (dF/dSOC), are identified. Utilizing these thresholds, the charging rate can be self-regulated. The results demonstrate that charging speed can be increased by 50% without causing irreversible lithium plating. The proposed method holds great promise for integration into intelligent battery management systems, thereby enhancing the performance of MCC fast charging.}, archive = {J_ADVS}, author = {Yudong Shen and Xueyuan Wang and Yuguang Li and Zhichao Zhang and Zhengde Tao and Yanan Hou and Xuezhe Wei and Haifeng Dai}, doi = {10.1002/advs.202504580}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04580}, shortjournal = {Adv. Sci.}, title = {Expansion force-based adaptive multistage constant current fast charging with lithium plating detection for lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). A new quasi-solid polymer electrolyte for next-generation Na–O2 batteries: Unveiling the potential of a polyamide-polyether system. ADVS, 12(30), e04490. (www)

  @article{ , abstract = {A novel quasi-solid polymer electrolyte (QSPE) composed of polyamide (PA) and polyethylene oxide (PEO), commercially known as Pebax1657, and combined with 1 M sodium bis(trifluoromethanesulfonyl)imide (NaTFSI) in diethylene glycol dimethyl ether (diglyme, DEGDME), has been investigated for sodium–oxygen (Na–O 2 ) batteries. Pebax1657 QSPE exhibits high ionic conductivity (6.57 × 10 −4 S cm −1 at room temprerature - RT), an oxidation onset potential of 4.69 V versus Na/Na⁺, and an enhanced Na⁺ transference number (t Na ⁺ ≈ 0.40). Structural analysis (Raman spectroscopy, differential scanning calorimetry, X-ray diffraction, small-angle X-ray scattering) confirms reduced PEO crystallinity and formation of orderly nanodomains, facilitating Na⁺ transport. Long-term galvanostatic cycling in Na|Na symmetrical cells demonstrates stable overpotentials (≈80 mV) at 75 µA cm⁻ 2 for 210 h, outperforming conventional liquid electrolytes (≈110 h). Pebax1657 QSPE enables higher discharge capacities (2.60 mAh cm⁻ 2 at 75 µA cm⁻ 2 ; 2.11 mAh cm⁻ 2 at 150 µA cm⁻ 2 ) with lower overpotentials (≈0.2 V). It sustains 25 cycles at 75 µA cm⁻ 2 and 35 cycles at 150 µA cm⁻ 2 at 0.25 mAh cm⁻ 2 , with a Coulombic Efficiency (CE) of 80–90%. Compared to the state of the art, Pebax1657 QSPE offers improved electrochemical stability, lower overpotentials, and better capacity retention. Its sustainability and versatility make it a strong candidate for Na–O 2 batteries and other energy storage applications.}, archive = {J_ADVS}, author = {Mohamed Yahia and Marina Enterría and Cristina Pozo-Gonzalo and Nagore Ortiz-Vitoriano}, doi = {10.1002/advs.202504490}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04490}, shortjournal = {Adv. Sci.}, title = {A new quasi-solid polymer electrolyte for next-generation Na–O2 batteries: Unveiling the potential of a polyamide-polyether system}, volume = {12}, year = {2025}, }
• (2025). Dual-band electrochromic smart window for dynamic switching between radiative cooling and solar heating. ADVS, 12(30), e04483. (www)

  @article{ , abstract = {Electrochromic smart windows can actively modulate their reversible transition between transparent and opaque states, adapting to varying climatic conditions and thereby offering a sustainable solution for energy-efficient buildings. However, the operational range of current electrochromic smart windows is mostly limited to the solar spectrum. Expanding this range into the mid-infrared spectrum could significantly enhance their energy-saving capabilities. In this study, a dynamic electrochromic (EC) glass that integrates silver electrodeposition/dissolution with mechanical flipping of the glass panel is designed. This design enables bidirectional dynamic modulation of both the solar spectrum (0.3–2.5 µm) and mid-infrared spectrum (2.5–20 µm), with solar reflectance varying between 87.9% and 19.9%, and mid-infrared emissivity varying between 90.6% and 10.8%. Consequently, the EC glass can dynamically switch between radiative cooling and solar heating modes. The simulation results show that the architectural application of this EC glass, with climate-specific operating modes, can achieve a maximum of over 50% annual heating, ventilation, and air conditioning (HVAC) energy savings, contributing to carbon neutrality and sustainable development.}, archive = {J_ADVS}, author = {Xinyu Zhao and Qixiang Chen and Fan Fan and Qiliang Wang and Yuehong Su and Minsu Liu and Fahua Zhu and Dongliang Zhao}, doi = {10.1002/advs.202504483}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04483}, shortjournal = {Adv. Sci.}, title = {Dual-band electrochromic smart window for dynamic switching between radiative cooling and solar heating}, volume = {12}, year = {2025}, }
• (2025). Near-freezing-temperature golgi neuronal staining for X-ray imaging of human brain. ADVS, 12(30), e04468. (www)

  @article{ , abstract = {Achieving detailed neuronal structural information in large-volume brain tissue has been a longstanding challenge in human brain imaging. A key obstacle arises from the trade-off between staining efficiency and tissue autolysis. Traditional Golgi staining, typically conducted at room temperature or 37 °C to optimize staining efficiency, leads to rapid autolysis of brain tissue, resulting in the loss of fine structural details. Here, a near-freezing temperature (NFT) staining strategy in post-mortem frozen (PMF) human brain samples are presented, using a mercury chloride-based method under ice-water bath conditions. In contrast to the 37 °C Golgi staining, this NFT-based method significantly reduces tissue autolysis, preserving fine neuronal structures. Notably, neuronal counts in the same field of view increased by 5.5-fold, and dendritic spine density increases by 22-fold. Using this approach, uniform staining of millimeter-thick is achieved, centimeter-scale human brain slices and integrated it with synchrotron-based X-ray microscopy to perform micrometer resolution 3D reconstructions of the cerebellum and frontal lobe. This novel technique offers a powerful tool for the fine-structural imaging of large-volume brain tissue, providing new insights into the intricate organization of neural networks.}, archive = {J_ADVS}, author = {Feng Zhou and Qiaowei Tang and Xin Yan and Chao Ma and Yu Zhang and Jichao Zhang and Qian Li and Lihua Wang and Jun Hu and Xiaoqing Cai and Jiang Li and Ying Zhu and Chunhai Fan}, doi = {10.1002/advs.202504468}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04468}, shortjournal = {Adv. Sci.}, title = {Near-freezing-temperature golgi neuronal staining for X-ray imaging of human brain}, volume = {12}, year = {2025}, }
• (2025). Multiscale organization of neural networks in a 3D bioprinted matrix. ADVS, 12(30), e04455. (www)

  @article{ , abstract = {The efficient establishment of in vitro neural models that accurately mimic the structural and functional connectivity of neural networks is critical in neuroscience research. 3D bioprinting shows great potential for constructing sophisticated in vitro models with high freedom of design. However, mature neurons are delicate and susceptible to manipulation. Here, extrusion-based 3D bioprinting is employed to fabricate gelatin methacryloyl (GelMA)-based constructs containing embryonic day 18 (E18) rat cortical neurons, referred to as 3D neuMatrix. 3D neuMatrix displays favorable neuronal viability, with the progressive formation of a 3D brain-like neural network with local and long-range functional axon connections. Compared with 2D cultured neurons, 3D neuMatrix is more similar to the E18 cortex according to the bulk transcriptomic profile, with a recreation of cellular components in the cerebral cortex. The 3D neuMatrix is employed to establish a disease model of ischemic stroke, with a faithful recapitulation of the viability, function, and transcriptomic features of rats with middle cerebral artery occlusion/reperfusion (MCAO/R). These findings demonstrate the formation of multiscale neural circuits within 3D neuMatrix and its valuable potential in the study of neurodevelopment, disease modeling with drug screening, and in vitro intelligence.}, archive = {J_ADVS}, author = {Huiyu Yang and Jiangang Zhang and Yiran Li and Zihan Zhong and Wenhua Li and Haojun Luo and Yanyong Liu and Liujian Ouyang and Zhuoran Jiang and Yuning Sun and Hang Sun and Lulu Liu and Huayu Yang and Yu Wang and Nan Yang and Wenbin Ma and Yilei Mao}, doi = {10.1002/advs.202504455}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04455}, shortjournal = {Adv. Sci.}, title = {Multiscale organization of neural networks in a 3D bioprinted matrix}, volume = {12}, year = {2025}, }
• (2025). Exosomal CMTM4 induces immunosuppressive macrophages to promote ovarian cancer progression and attenuate anti-PD-1 immunotherapy. ADVS, 12(30), e04436. (www)

  @article{ , abstract = {Exosomes shape the tumor microenvironment (TME) by modulating tumor-associated macrophages (TAMs) and promoting ovarian cancer (OC) progression. This study reveals that exosomal CKLF Like MARVEL Transmembrane Domain Containing 4 (CMTM4) enhances OC malignancy and orchestrates immune evasion. Excessive macrophage infiltration in the TME, particularly in the presence of CMTM4, is strongly associated with poor prognosis. Within the TME, exosomal CMTM4 is actively internalized by macrophages, promoting M2 polarization and subsequently initiating immunosuppressive signaling. Exosomal CMTM4 activates the NF-κB pathway in TAMs, suppressing immune function through enhanced secretion of cytokines, including TGF-β1 and CXCL12, while simultaneously upregulating intercellular adhesion molecule-1 (ICAM1) expression to further promote M2 polarization and facilitate cancer metastasis. Depletion of CMTM4 increases sensitivity to anti-PD-1 therapy by reversing immunosuppression. Notably, eltrombopag is identified as a CMTM4 inhibitor that attenuates OC progression in vivo and modulates the tumor immune microenvironment, synergizing with PD-1 blockade immunotherapy to enhance therapeutic efficacy. The exosomal CMTM4—ICAM1—CD206 axis exacerbates disease risk in patients with OC. Collectively, the study highlights the critical role of tumor-derived exosomal CMTM4 in immune suppression, emphasizing its potential as both a prognostic biomarker and a therapeutic target in OC immunotherapy.}, archive = {J_ADVS}, author = {Bo Yin and Jianyi Ding and Jie Liu and Haoran Hu and Yashi Zhu and Meiqin Yang and Huijuan Zhou and Baoyou Huang and Tiefeng Huang and Mengjie Li and Yinyan He and Ang Li and Lingfei Han}, doi = {10.1002/advs.202504436}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04436}, shortjournal = {Adv. Sci.}, title = {Exosomal CMTM4 induces immunosuppressive macrophages to promote ovarian cancer progression and attenuate anti-PD-1 immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Multi-omics and -organ insights into energy metabolic adaptations in early sepsis onset. ADVS, 12(30), e04418. (www)

  @article{ , abstract = {Systemic metabolic dysregulation in sepsis critically impacts patient survival. To better understand its onset, untargeted serum metabolomics and lipidomics are analyzed from 152 presymptomatic patients undergoing major elective surgery, and identified key metabolites, including serine and aminoadipic acid, that differentiate postoperative uncomplicated infection from sepsis. Using single-nucleus RNA sequencing data from an in vivo mouse model of sepsis, tissue-independent down-regulation and tissue-specific differences of serine and energy-related genes including key module roles for the mitochondria-linked genes, Cox4i1 , Cox8a , and Ndufa4 are identified. Finally, serine-dependent metabolic shifts, especially in the liver, are revealed by using 12 C/ 13 C murine data with labeled serine, and link altered activity of the serine hydroxymethyltransferase (SHMT) cycle with perturbed purine metabolism during sepsis. This study demonstrates the close interrelationship between early metabolite changes and mitochondrial dysfunction in sepsis, improves the understanding of the underlying pathophysiology, and highlights metabolic targets to prospectively treat presymptomatic, but at-risk, patients.}, archive = {J_ADVS}, author = {Lin-Lin Xu and Zhengyuan Zhou and Sascha Schäuble and Wolfgang Vivas and Karen Dlubatz and Michael Bauer and Sebastian Weis and Mervyn Singer and Roman Lukaszewski and Gianni Panagiotou}, doi = {10.1002/advs.202504418}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04418}, shortjournal = {Adv. Sci.}, title = {Multi-omics and -organ insights into energy metabolic adaptations in early sepsis onset}, volume = {12}, year = {2025}, }
• (2025). Dynamic bonds reinforced polyamide elastomer for biomedical orthosis. ADVS, 12(30), e04395. (www)

  @article{ , abstract = {4D printing of shape memory polymers (SMPs) allows the 3D-printed structures to have adjustable shapes, properties, and functionalities, paving the way for intelligent devices and multifunctional applications. However, 4D-printed SMPs face challenges due to mechanical anisotropy and mediocre shape memory performance hampered by weak interlayer adhesion. This study innovatively integrates shape memory polyamide elastomer with 4D printing technology to develop a multifunctional intelligent orthosis. Here, a dynamic bonds (DBs) reinforced shape memory polyamide elastomer is developed using a twin-screw extruder through reactive extrusion. Dynamic covalent networks are introduced into polyamide elastomer, which enhances interlayer adhesion in 4D-printed objects by utilizing combined effects of multiple dynamic covalent bonds (DCBs) and hierarchical hydrogen bonds (DHBs), leading to the reduction of mechanical anisotropy and improvement of the mechanical and shape memory properties of the 4D printouts. 4D-printed objects demonstrated excellent macroscopic shape memory and reconfiguration, showcasing the versatility of this material, and the application for spinal orthosis is also demonstrated.}, archive = {J_ADVS}, author = {Zhen Li and Peiyao Yan and Hao Wang and Yuancheng Zhang and Junhua Kong and Wei Zhao and Xin Li and Xiaomeng Zhang and Zhe Cui and Peng Fu and Xinchang Pang and Minying Liu and Chaobin He}, doi = {10.1002/advs.202504395}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04395}, shortjournal = {Adv. Sci.}, title = {Dynamic bonds reinforced polyamide elastomer for biomedical orthosis}, volume = {12}, year = {2025}, }
• (2025). PIP5K1A suppresses ferroptosis and induces sorafenib resistance by stabilizing NRF2 in hepatocellular carcinoma. ADVS, 12(30), e04372. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, has emerged as a promising strategy for cancer treatment. However, the development of ferroptosis resistance limits the efficacy of such treatments. This study reports that phosphatidylinositol 4-phosphate 5-kinase 1 alpha (PIP5K1A) promotes HCC tumorigenesis and predicts poor prognosis in HCC patients. Knockdown of PIP5K1A enhances lipid peroxidation and increases sensitivity to sorafenib-induced ferroptosis by inhibiting the activation of downstream ferroptosis-related genes regulated by nuclear factor erythroid-2-related factor 2 (NRF2). Mechanistically, PIP5K1A competitively binds to the Kelch domain of Kelch-like ECH-associated protein 1 in a kinase-independent manner, leading to NRF2 escaping from ubiquitination degradation, thereby promoting NRF2-dependent transcription and suppressing ferroptosis. Furthermore, ISA-2011B, a PIP5K1A-specific inhibitor, effectively inhibits HCC growth and sensitized HCC cells to sorafenib. In conclusion, PIP5K1A is a promising therapeutic target for improving the efficacy of sorafenib and other ferroptosis inducers in HCC.}, archive = {J_ADVS}, author = {Mengzhou Guo and Sinuo Chen and Jialei Sun and Ruchen Xu and Zhuoran Qi and Jie Li and Lianer Zhou and Yuan Fang and Tianshu Liu and Jinglin Xia}, doi = {10.1002/advs.202504372}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04372}, shortjournal = {Adv. Sci.}, title = {PIP5K1A suppresses ferroptosis and induces sorafenib resistance by stabilizing NRF2 in hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Current approaches and challenges in advanced oxidation processes for nanoplastic degradation. ADVS, 12(30), e04352. (www)

  @article{ , abstract = {The proliferation of plastic production has led to a surge in nanoplastic (NPs) pollution, posing significant environmental and health risks. Despite efforts to mitigate plastic waste, NPs persist as a significant challenge due to their small size, high surface-to-volume ratio, and complex nature. This review analyzes existing research on advanced oxidation processes, focused exclusively on NPs remediation, including ozonation, electrochemical, photocatalytic, and plasma-induced processes. Gaps in the development of effective processes and analytical methods for the treatment of such plastic particles with sizes lower than 1 µm are highlighted, and future directions are suggested. This study aims to improve understanding and support sustainable solutions for the remediation of NPs from contaminated water sources, in alingment with the United Nations' Sustainable Development Goal 6.}, archive = {J_ADVS}, author = {Arezou Fazli and Athanassia Athanassiou and Despina Fragouli}, doi = {10.1002/advs.202504352}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04352}, shortjournal = {Adv. Sci.}, title = {Current approaches and challenges in advanced oxidation processes for nanoplastic degradation}, volume = {12}, year = {2025}, }
• (2025). Current progress and challenges of electromagnetic wave absorbing materials at high temperature. ADVS, 12(30), e04286. (www)

  @article{ , abstract = {With the rapid development of science and technology, electromagnetic waves have deeply penetrated various fields. However, they also bring a higher demand for electromagnetic protection. Electromagnetic wave absorbing materials (EMWAMs) can significantly reduce or even eliminate the reflection and scattering of electromagnetic waves by converting electromagnetic wave energy into heat energy and dissipation. In recent years, the research work on EMWAMs mainly focuses on the material systems applied at the normal temperature, and its absorption mechanism is systematically discussed. However, at the elevated temperature, the electromagnetic loss mechanism changes, and the suitable EMWAMs become limited. At the same time, the testing method of EMWAMs at high temperature also remains a challenge. In this work, the electromagnetic loss mechanism and testing methods for high-temperature EMWAMs, especially above 800 °C, are discussed. Based on this, a selection criterion for EMWAMs at high temperature is proposed.}, archive = {J_ADVS}, author = {Zhixiao Wang and Tao Yang and Linlin Zhou and Xinmei Hou and Zhi Fang and Yanglong Hou}, doi = {10.1002/advs.202504286}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04286}, shortjournal = {Adv. Sci.}, title = {Current progress and challenges of electromagnetic wave absorbing materials at high temperature}, volume = {12}, year = {2025}, }
• (2025). Superconducting carbon-cage network with tc of 109 k at ambient pressure. ADVS, 12(30), e04281. (www)

  @article{ , abstract = {A novel carbon-cage network was reported, denoted as C 18 , found to be a low energy structure by first principles particle swarm structure search. The compound exhibits high temperature electron–phonon ambient pressure superconductivity with T c = 79 K for elemental doping and can be raised to T c = 109 K by appropriate hole doping. Analyses of the phonon spectra, molecular dynamics simulations, and enthalpy differences relative to analogous structures synthesized experimentally all suggest that the hole-doped high- T c structure is a viable candidate for experimental synthesis.}, archive = {J_ADVS}, author = {Z. F. Ye and David J. Singh and Y. N. Huang and Guo-Hua Zhong and Hai-Qing Lin}, doi = {10.1002/advs.202504281}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04281}, shortjournal = {Adv. Sci.}, title = {Superconducting carbon-cage network with tc of 109 k at ambient pressure}, volume = {12}, year = {2025}, }
• (2025). Assembling hexahedral supramolecular nano-aggregates on rice wax layer matrices to promote the leaf deposition and bioavailability of bactericides for plant protections. ADVS, 12(30), e04225. (www)

  @article{ , abstract = {Naturally hydrophobic wax layer microstructures in plants seriously hinder the leaf adhesion and deposition of pesticide droplets, thereby causing low pesticide bioavailability and inevitable environmental pollution. Inspired by the supramolecular self-assembly strategy, two anisotropic supramolecular building units (BiTA18@ β -CD and BiTA18@ γ -CD) are invented based on the host–guest complexation between a benzimidazole-modified bactericidal molecule (BiTA18) and β -/ γ -cyclodextrin ( β -CD/ γ -CD), which self-assemble into nano-sized hexagonal cuboids on the rice microcrystalline matrix. This consequence markedly enhances the retention of bactericidal ingredients on target plants. More intriguingly, these oligosaccharide-coated supramolecular materials, with superior biocompatibility, can break through the bacterial biofilm barrier, limit bacterial motility and extracellular enzyme secretion, and induce electrolyte leakage and ROS accumulation in bacteria, ultimately annihilating the stubborn pathogenic bacterium. Combining these excellent advantages, the optimal supramolecular material (BiTA18@ β -CD) displays broad-spectrum and efficient control efficacies of 54.4% and 71.7% against rice bacterial blight and citrus bacterial canker, respectively, surpassing those of kasugamycin (34.3%/34.1%), thiodiazole-copper-20%SC (39.9%/42.7%), and BiTA18 (42.7%/46.9%) at 200 µg mL −1 . Besides, the current supramolecular systems are safe for non-target organisms like earthworms and zebrafishes. This study provides a key inspiration for the construction of supramolecular building units assembled on rice microcrystalline substrates to improve the utilization of pesticides.}, archive = {J_ADVS}, author = {Run Yang and Jinghan Yang and Min Liu and Juan Liu and Peiyi Wang}, doi = {10.1002/advs.202504225}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04225}, shortjournal = {Adv. Sci.}, title = {Assembling hexahedral supramolecular nano-aggregates on rice wax layer matrices to promote the leaf deposition and bioavailability of bactericides for plant protections}, volume = {12}, year = {2025}, }
• (2025). Embedding monodisperse LaOx into pt nanoclusters for ultra-stable and efficient hydrogen isotope oxidation. ADVS, 12(30), e04224. (www)

  @article{ , abstract = {Catalytic oxidation plays a crucial role in the efficient treatment of hydrogen isotopes, with the key technical challenge being the development of high-performance catalysts to enhance isotope removal efficiency, thereby reducing environmental pollution and ensuring public radiation safety. Herein, the strategic control of platinum nanoclusters confined within silicalite-1 zeolites is reported to enhance the high removal efficiency for hydrogen isotopes under low-temperature conditions for the first time. Incorporating a single lanthanum oxide (LaO x ) into Pt nanoclusters adapts the local charge of adjacent Pt atoms, significantly altering their electronic structure. The existence of individual LaO x species is confirmed by X-ray absorption spectroscopy and aberration-corrected electron microscopy, and the performance enhancement mechanism is further probed by theoretical calculations. This embedded single LaO x both facilitates local charge adjustment and supplies abundant active oxygen species, leading to performance enhancement by reducing the energy barrier of rate-determining step (O * + H → OH * ), in accordance with the Mars-van Krevelen mechanism. Consequently, during a surprisingly long-term restart performance test (≈267 d), the PtLaOx@S-1 maintained a high conversion rate over 99% at 50 °C and a space velocity of 48,000 mL·g −1 ·h −1 . This study highlights the potential of individual LaO x sites for enhancing hydrogen isotope oxidation.}, archive = {J_ADVS}, author = {Guilin Wei and Jiangfeng Song and Yan Shi and Linsen Zhou and Xianglin Wang and Junhong Luo and Ning Liu and Feize Li and Xingwen Feng}, doi = {10.1002/advs.202504224}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04224}, shortjournal = {Adv. Sci.}, title = {Embedding monodisperse LaOx into pt nanoclusters for ultra-stable and efficient hydrogen isotope oxidation}, volume = {12}, year = {2025}, }
• (2025). Akkermansia muciniphila alleviates severe acute pancreatitis via amuc1409-ube2k-foxp3 axis in regulatory t cells. ADVS, 12(30), e04214. (www)

  @article{ , abstract = {Severe acute pancreatitis (SAP) is a critical condition characterized by an imbalance between systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS). Disruptions in intestinal microbiota exacerbate this imbalance; however, the mechanisms by which commensal bacteria regulate SAP-induced SIRS and/or CARS remain unclear. This study reports that the abundance of the gut commensal Akkermansia is significantly reduced in fecal samples from patients with acute pancreatitis (AP) and is inversely associated with the severity of systemic inflammatory responses. Using Foxp3-DTR and IL-10-KO mice, it is found that Akkermansia muciniphila and its derived protein Amuc_1409 can suppress SAP-induced pancreatic and systemic inflammation by increasing peripheral regulatory T cells (Tregs) and enhancing the IL-10 expression. Mechanistically, Amuc_1409 interacts with Ube2k to reduce the ubiquitination degradation of Foxp3, and it promotes the differentiation of Tregs and the production of IL-10, effectively alleviating inflammation induced by SAP. These findings highlight A. muciniphila and its derivative Amuc_1409 as promising probiotic and biomolecule for managing acute pancreatitis and potentially other inflammatory conditions.}, archive = {J_ADVS}, author = {Jinyan Xie and Lijun Du and Yunkun Lu and Xiuliu Guo and Xinyuan Zhou and Yifan Tong and Bo Shen and Xin Yu and Feng Guo and Hong Yu}, doi = {10.1002/advs.202504214}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04214}, shortjournal = {Adv. Sci.}, title = {Akkermansia muciniphila alleviates severe acute pancreatitis via amuc1409-ube2k-foxp3 axis in regulatory t cells}, volume = {12}, year = {2025}, }
• (2025). Bimetallic plasmonic nanozyme-based microneedle for synergistic ferroptosis therapy of melanoma. ADVS, 12(30), e04203. (www)

  @article{ , abstract = {Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity. Conventional therapies often yield poor outcomes, posing significant clinical challenges. Here, a microneedle (MN) patch that integrates nanozyme and traditional Chinese medicine (TCM) for ferroptosis pathway-dependent combined therapy of melanoma is designed. To amplify therapeutic activity, a novel Au@MoS 2 bimetallic plasmonic nanozyme (BPNzyme) is prepared through a simple aqueous synthesis strategy involving a two-step process. Owing to the synergy between heterostructures, this rationally designed BPNzyme exhibits significantly enhanced therapeutic characteristics, including near-infrared (NIR) photothermal effect, peroxidase-like activity, and glutathione peroxidase-like property, which can effectively reshape the tumor microenvironment and disrupt the redox homeostasis. Under the combined action of the TCM β-elemene (β-ELE) and NIR light, further enhancement of oxidative damage, lipid peroxidation, and glutathione peroxidase 4 expression downregulation are observed for skin tumor cells, validating the synergistic amplification of ferroptosis. Moreover, the transdermal delivery of BPNzyme and β-ELE using the soluble hyaluronic acid MN patch effectively achieves 99.8% tumor growth suppression without significant systemic toxicity in vivo. These findings highlight the potential of the rationally designed BPNzyme-based MN system as a promising innovative strategy for non-invasive, efficient, and safe combination therapy of melanoma.}, archive = {J_ADVS}, author = {Wei Duan and Keying Xu and Yue Gao and Sheng Huang and Xueqian Xia and Xiang Liu and Shuangxue Pan and Chunpeng Jiao and Weijian Cheng and Yong Guo and Jingwen Zhao and Jia-Wei Shen}, doi = {10.1002/advs.202504203}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04203}, shortjournal = {Adv. Sci.}, title = {Bimetallic plasmonic nanozyme-based microneedle for synergistic ferroptosis therapy of melanoma}, volume = {12}, year = {2025}, }
• (2025). Neutrophil-mimicking nanomedicine eliminates tumor intracellular bacteria and enhances chemotherapy on liver metastasis of colorectal cancer. ADVS, 12(30), e04188. (www)

  @article{ , abstract = {Fusobacterium nucleatum ( Fn ) enrichment has been identified in colorectal cancer and its liver metastases. In this study, we found that Fn predominantly accumulated within colorectal cancer cells, correlating with colorectal cancer liver metastasis. Clinically, the administration of high doses of antibiotics and chemotherapeutic agents can disrupt the balance of the host microbiota. To address this clinical challenge, metronidazole (MTI) and oxaliplatin (OXA) are encapsulated within poly (lactic-co-glycolic acid) (PLGA) nanoparticles. Neutrophil membrane vesicles are extracted from murine bone marrow and coated with these nanoparticles (NM@PLGA-MTI-OXA), creating neutrophil-mimetic nanoparticles with dual targeting capabilities for antibacterial and anticancer purposes. The neutrophil membrane coating, compared with free drugs, is found to enhance nanoparticle uptake by tumor cells, facilitating intracellular bacterial elimination and tumor cell death. Further experiments reveal that NM@PLGA-MTI-OXA reverses the Fn -induced epithelial-mesenchymal transition (EMT) in tumor cells during metastasis and remodels the immunosuppressive microenvironment, suppressing colorectal cancer and liver metastasis development while minimizing broad-spectrum damage to the commensal microbiota.}, archive = {J_ADVS}, author = {Yanan Niu and Xu Zhao and Yong Li and Xiaoya Ma and Weifeng Yang and Jie Ma and Wanglin Li and Wei Yuan}, doi = {10.1002/advs.202504188}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04188}, shortjournal = {Adv. Sci.}, title = {Neutrophil-mimicking nanomedicine eliminates tumor intracellular bacteria and enhances chemotherapy on liver metastasis of colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Scalable multifunctional fabrics with boosted intrinsic photothermal efficiency for salt-resistant solar-driven janus evaporators. ADVS, 12(30), e04100. (www)

  @article{ , abstract = {Global population growth and climate change are causing freshwater scarcity, which necessitates creative solutions like solar-driven desalination. This technology's widespread adoption is hampered by cost and efficiency issues. Intrinsic photothermal conversion efficiency has gotten less attention than light trapping and thermal management, which have been the main focuses of efforts to increase photo-to-vapor efficiencies. Here, a commercial padding and vapor polymerization method are used to develop scalable nylon fabrics that act as solar absorbers. This is achieved by anchoring iron catalysts with hydrolyzed perfluorooctyltriethoxysilane chains, which cause confined polymerization of pyrrole to generate polypyrrole. By narrowing the bandgap and generating bioinspired light-trapping nanostructures, this technique achieves a superior intrinsic photothermal conversion efficiency of 84.6%, which is 4.94 times higher than that of unconfined polymerization. These fabrics are used to create a Janus evaporator, which operates steadily in prolonged seawater testing and shows an evaporation rate of 3.84 kg m −2 h −1 . The low manufacturing cost of ≈28 RMB m −2 emphasizes its scalability and economic potential. This work offers insights into the design of high-performance, scalable, and cost-effective solar absorbers by prioritizing increases in light absorption and intrinsic photothermal conversion efficiencies for developing solar desalination technology.}, archive = {J_ADVS}, author = {Mingqing Yu and Jiaqi Hu and Xinghao Li and Linchu Xu and Huawei Hu and Robert T. Woodward and Wei Lyu and Yaozu Liao}, doi = {10.1002/advs.202504100}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04100}, shortjournal = {Adv. Sci.}, title = {Scalable multifunctional fabrics with boosted intrinsic photothermal efficiency for salt-resistant solar-driven janus evaporators}, volume = {12}, year = {2025}, }
• (2025). Unveiling sodium diffusion kinetics and locking mechanisms for high-performance CZTSSe photovoltaics. ADVS, 12(30), e04087. (www)

  @article{ , abstract = {This work unveils a diffusion-kinetic modulation strategy that fundamentally redefines sodium management in kesterite photovoltaics, enabling spatially controlled Na sequestration within Cu 2 ZnSn(S,Se) 4 (CZTSSe) absorber layers through a thermally engineered “Na-locking” mechanism. By establishing critical correlations between post-processing thermal protocols and alkali metal migration dynamics, how synchronized extension of sintering duration and rapid cooling termination creates a non-equilibrium state that traps Na at strategic interfacial positions is demonstrated. This approach leverages Na's dual functionality as a crystallization promoter and defect passivator, driving concurrent improvements in crystallographic coherence and electronic uniformity. The optimized absorber architecture features laterally expanded grains with reduced boundary density and homogenized interfacial charge transport pathways, yielding the highest reported efficiency of 13.22% for Na-doped CZTSSe solar cells to date, marked by synergistic enhancements in both V OC and FF . Crucially, this substrate-derived Na regulation paradigm outperforms conventional extrinsic doping methods through its self-limiting diffusion characteristics, ensuring compositional stability while eliminating secondary phase risks. The methodology establishes a universal framework for defect engineering in chalcogenide photovoltaics, bridging fundamental insights into alkali metal diffusion thermodynamics with scalable manufacturing solutions. These findings advance kesterite solar cell technology and offer a blueprint for optimizing thin-film devices, improving process tolerance and material sustainability.}, archive = {J_ADVS}, author = {Shuyu Li and Chaoran Li and Chu Liu and Jiachen Wu and Letu Siqin and Yuan Li and Guonan Cui and Yanchun Yang and Ruijian Liu and Hongmei Luan and Chengjun Zhu}, doi = {10.1002/advs.202504087}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e04087}, shortjournal = {Adv. Sci.}, title = {Unveiling sodium diffusion kinetics and locking mechanisms for high-performance CZTSSe photovoltaics}, volume = {12}, year = {2025}, }
• (2025). HPD is an RNA-binding protein sustaining ovarian cancer cell glycolysis, tumor growth, and drug resistance. ADVS, 12(30), e03999. (www)

  @article{ , abstract = {4-hydroxyphenylpyruvate dioxygenase (HPD) is an important metabolic enzyme in the tyrosine metabolic pathway and displays aberrant expression and function in cancer. Unexpectedly, it is discovered that HPD functions as an RNA-binding protein (RBP) to drive ovarian cancer progression. HPD is shown to bind to the RRACH motif of these target mRNAs through its two dsRNA binding domains (RBDs), resulting in increased global mRNA translation. In particular, HPD binding is demonstrated to mediate translation of glycolytic enzymes triosephosphate isomerase (TPI) and alpha-enolase (ENO1) mRNAs, which facilitates ovarian cancer glycolysis and tumor growth. Thus, targeting the RBD domain of HPD disrupts its RNA binding ability, leading to blocking glycolysis flux, tumor growth, and enhancing drug response. HPD is a novel RNA-binding protein, and this moonlighting function highlights the knowledge of HPD in regulating cancer development and drug response beyond only as a metabolic enzyme.}, archive = {J_ADVS}, author = {Fei Xie and Han Zhang and Xintong Dai and Mengxin Tu and Chenxi Yu and Lumeng Liu and Yajuan Guo and Huanran Sun and Qingle Gao and Jiyan Wang and Mingming Sun and Qijun Zhang and Taoyuan Wang and Tao He and Zhen Li and Yanping Li and Tao Wang and Jianguo Zhao and Zhongjie Chen and Chunze Zhang and Shuai Zhang and Changliang Shan}, doi = {10.1002/advs.202503999}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03999}, shortjournal = {Adv. Sci.}, title = {HPD is an RNA-binding protein sustaining ovarian cancer cell glycolysis, tumor growth, and drug resistance}, volume = {12}, year = {2025}, }
• (2025). Revealing the mechanism of exciton spontaneous separation at room temperature for efficient photocatalytic hydrogen peroxide synthesis. ADVS, 12(30), e03929. (www)

  @article{ , abstract = {The photocatalytic synthesis of hydrogen peroxide (H 2 O 2 ) at room temperature has garnered significant attention as an environmentally friendly alternative to traditional anthraquinone oxidation processes. However, the low exciton dissociation efficiency at room temperature often hinders photocatalytic performance. In this study, it is demonstrated that tuning the substitution sites of electron donors in Donor-Acceptor (D-A) conjugated polymers can significantly enhance exciton dissociation by reducing exciton activation energy, which facilitates the spontaneous separation of excitons at room temperature. For comparison, materials with exciton separation energies ≈89 meV exhibit a hydrogen peroxide production rate of 2692 µmol·g −1 ·h −1 . In contrast, the main material developed in this work, O-PTAQ, demonstrates a substantially lower exciton separation energy of 22 meV, resulting in a hydrogen peroxide production rate of 4989 µmol·g −1 ·h −1 under ambient conditions, outperforming most reported organic semiconductors. This enhancement is attributed to the increased electron delocalization in the electron donors, which lowers exciton activation energy to promote efficient exciton separation. The findings highlight the critical role of molecular-level structural tuning in enhancing exciton dissociation, providing a promising strategy for the development of high-efficiency photocatalysts for sustainable H 2 O 2 production.}, archive = {J_ADVS}, author = {Pan Jiang and Yuyan Huang and Xiangqiong Jiang and Huijie Yan and Shufang Liu and Zuoming Chen and Xin Wu and Xiantai Zhou and Yu-Xin Ye and Gangfeng Ouyang}, doi = {10.1002/advs.202503929}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03929}, shortjournal = {Adv. Sci.}, title = {Revealing the mechanism of exciton spontaneous separation at room temperature for efficient photocatalytic hydrogen peroxide synthesis}, volume = {12}, year = {2025}, }
• (2025). PlantGPT: An arabidopsis-based intelligent agent that answers questions about plant functional genomics. ADVS, 12(30), e03926. (www)

  @article{ , abstract = {Research into plant gene function is crucial for developing strategies to increase crop yields. The recent introduction of large language models (LLMs) offers a means to aggregate large amounts of data into a queryable format, but the output can contain inaccurate or false claims known as hallucinations. To minimize such hallucinations and produce high-quality knowledge-based outputs, the abstracts of over 60 000 plant research articles are compiled into a Chroma database for retrieval-augmented generation (RAG). Then linguistic data are used from 13 993 Arabidopsis ( Arabidopsis thaliana ) phenotypes and 23 323 gene functions to fine-tune the LLM Llama3-8B, producing PlantGPT, a virtual expert in Arabidopsis phenotype–gene research. By evaluating answers to test questions, it is demonstrated that PlantGPT outperforms general LLMs in answering specialized questions. The findings provide a blueprint for functional genomics research in food crops and demonstrate the potential for developing LLMs for plant research modalities. To provide broader access and facilitate adoption, the online tool http://www.plantgpt.icu is developed, which will allow researchers to use PlantGPT in their scientific investigations.}, archive = {J_ADVS}, author = {Ruixiang Zhang and Yu Wang and Weiyang Yang and Jun Wen and Weizhi Liu and Shipeng Zhi and Guangzhou Li and Nan Chai and Jiaqi Huang and Yongyao Xie and Xianrong Xie and Letian Chen and Miao Gu and Yao-Guang Liu and Qinlong Zhu}, doi = {10.1002/advs.202503926}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03926}, shortjournal = {Adv. Sci.}, title = {PlantGPT: An arabidopsis-based intelligent agent that answers questions about plant functional genomics}, volume = {12}, year = {2025}, }
• (2025). Interfacial polarization switching in Al0.92Sc0.08N/GaN heterostructures grown by sputter epitaxy. ADVS, 12(30), e03827. (www)

  @article{ , abstract = {The integration of ferroelectric nitride Al 1-x Sc x N onto GaN templates can enable enhanced functionality in novel high-power transistors and memory devices. This requires a detailed understanding of ferroelectric domain structures and their impact on the electrical properties. In this contribution, the sputter epitaxy of highly coherent Al 0.92 Sc 0.08 N thin films grown on GaN approaching lattice-matching conditions is demonstrated. Scanning transmission electron microscopy (STEM) investigations reveal polar domains and the mechanism of domain propagation upon ferroelectric switching. Atomic resolution imaging suggests that polarization inversion commences by an interfacial switching process in which the monolayer next to the interface already changes its polarization from the as-grown M- to N-polarity. The atomic configurations of this planar polarization discontinuity are identified and systematic changes of the electronic structure are revealed by electron energy loss spectroscopy (EELS). Moreover, persistent domains with M-polarity are identified at the top Pt electrode interface after switching. These insights on the location and the atomic structure of ferroelectric domains in sputter deposited Al 0.92 Sc 0.08 N/GaN heterostructures are compared to metal organic chemical vapor deposition (MOCVD)-grown films and discussed with respect to their defect structure. This knowledge will support the development of future non-volatile memory devices and novel transistor structures based on ferroelectric nitride thin films via interface and defect engineering.}, archive = {J_ADVS}, author = {Niklas Wolff and Georg Schönweger and Md. Redwanul Islam and Ziming Ding and Christian Kübel and Simon Fichtner and Lorenz Kienle}, doi = {10.1002/advs.202503827}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03827}, shortjournal = {Adv. Sci.}, title = {Interfacial polarization switching in Al0.92Sc0.08N/GaN heterostructures grown by sputter epitaxy}, volume = {12}, year = {2025}, }
• (2025). A water-triggered sensor for self-powered flood alarming. ADVS, 12(30), e03815. (www)

  @article{ , abstract = {Devastating natural disasters are prompting the need for effective early warning systems. The warning systems relying on cables or batteries are much expensive and not suitable for low-lying areas or remote environments. This research proposes a water-triggered sensor that has no energy consumption in dry conditions while becoming activated in the presence of water. The sensor is self-powered by a switchable galvanic battery which is made of two metallic electrodes isolated by an ion-loaded xerogel. When the battery is subjected to a water environment, the rapid hydration of the xerogel arouses the redox reaction between two electrodes, subsequently outputting the electrical power to trigger the sensing system associated with timely signal generation and transmission. To ensure adequate stability and durability against the ambient humidity variation, the battery is sealed with a polymer coat which is inert to the moisture but permeable to water. Since the sensor can be built on a paper base, it is suitable for Miura origami which is beneficial for improving the output power and minimizing the sensor size. Outdoor experiments confirm that the sensor is able to rapidly discriminate floods and warn nearby people and remote-control centers.}, archive = {J_ADVS}, author = {Mingqi Zhao and Shanzhi Lyu and Yingchao Ma and Nan Zhang and Yapei Wang}, doi = {10.1002/advs.202503815}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03815}, shortjournal = {Adv. Sci.}, title = {A water-triggered sensor for self-powered flood alarming}, volume = {12}, year = {2025}, }
• (2025). Crafting the Organic–Inorganic interface with a bridging architecture for solid-state li-o2 batteries. ADVS, 12(30), e03664. (www)

  @article{ , abstract = {Solid-state lithium-oxygen batteries (SSLOBs) are offering unparalleled safety and exceptional electrochemical performance. Despite their promise, composite solid electrolytes (CSEs) fabricated through mechanical hybridization consistently manifest pronounced ceramic particle aggregation. In this study, a thin and flexible CSE is developed by integrating Li 10 GeP 2 S 12 (LGPS) with poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and implementing silane coupling agents to form a bridging framework across the organic–inorganic heterojunction interfaces. The engineered CSE exhibited remarkable room-temperature ionic conductivity reaching 1.05 × 10 −4 S cm −1 , superior electrochemical stability within an expanded voltage window extending to 4.9 V versus Li/Li + . Furthermore, lithium symmetrical cells revealed uniform lithium deposition/dissolution behavior over 3000 h. Integration of the thin-film CSE into SSLOBs yielded devices achieving specific discharge capacities of 12874 mAh g −1 , coupled with superior long-term operational stability throughout 120 cycles. The enhanced interfacial adhesion forces observed between the heterogeneous phases play a pivotal role in maintaining space charge region stability, subsequently promoting accelerated lithium-ion diffusion kinetics while optimizing charge transfer processes at the electrochemical interfaces. The systematic study presents an innovative synthetic strategy for engineering dimensionally-confined, sulfide-enriched CSEs.}, archive = {J_ADVS}, author = {Minghui Li and Kecheng Pan and Dulin Huang and Jing Wu and Zhenzhen Li and Yaying Dou and Zhang Zhang and Zhen Zhou}, doi = {10.1002/advs.202503664}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03664}, shortjournal = {Adv. Sci.}, title = {Crafting the Organic–Inorganic interface with a bridging architecture for solid-state li-o2 batteries}, volume = {12}, year = {2025}, }
• (2025). DDAH1 promotes cisplatin chemoresistance in patients with locally advanced nasopharyngeal carcinoma via the EGFR-JAK2-STAT3 pathway. ADVS, 12(30), e03647. (www)

  @article{ , abstract = {Cisplatin-based induction chemotherapy (IC) improves survival in patients with locally advanced nasopharyngeal carcinoma (LANPC). However, ≈30% of patients with LANPC receiving IC develop chemoresistance, and 20% experience disease progression. The relation between chemoresistance and Dimethylarginine dimethylaminohydrolase-1 (DDAH1) in NPC has not been mentioned in previous studies. To explore the regulatory mechanism and biological function of DDAH1 in cisplatin chemoresistance, NPC cell lines are subjected to overexpression and knockdown of DDAH1 in vitro, with findings further corroborated by in vivo chemosensitivity assays. The predictive value of DDAH1 expression is evaluated for survival and resistance to cisplatin-based IC in a cohort of 339 patients with LANPC. Overexpression of DDAH1 in NPC cell lines increases cisplatin resistance both in vitro and in vivo through binding to the intracellular domain of epidermal growth factor receptor (EGFR), enhancing its dimerization and phosphorylation, thereby promoting the activation of the JAK2-STAT3 pathway, which is dependent on EGFR and extracellular ligands and can be weakened by nimotuzumab. Clinically, DDAH1 positivity correlates with unfavorable 3-year survivals. This study identified DDAH1 as a prognostic marker and a potential therapeutic target for nimotuzumab to overcome treatment failure and chemoresistance in LANPC and other EGFR-positive cancers.}, archive = {J_ADVS}, author = {Jin-Hao Yang and Li Yuan and Qiu-Yan Chen and Kai-Qi Lan and Liang-Ji Li and Yu-Chen Li and Xiao-Yun Li and Xue-Song Sun and Lin-Quan Tang and Sai-Lan Liu and Hai-Qiang Mai}, doi = {10.1002/advs.202503647}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03647}, shortjournal = {Adv. Sci.}, title = {DDAH1 promotes cisplatin chemoresistance in patients with locally advanced nasopharyngeal carcinoma via the EGFR-JAK2-STAT3 pathway}, volume = {12}, year = {2025}, }
• (2025). Proton acceleration with relativistic electromagnetic shock. ADVS, 12(30), e03538. (www)

  @article{ , abstract = {Understanding the mechanisms behind the extreme energies of cosmic rays is crucial for unraveling fundamental physical processes in astrophysical environments. This study proposes a novel mechanism for accelerating cosmic-ray protons. By examining a high-velocity collision between an astrophysical object and static magnetic fields, the generation of an intense transverse electric field capable of trapping and accelerating protons are find to relativistic energies. Through Hamiltonian analysis, a scaling law that correlates the proton energy is derived to the minimum longitudinal thickness of the relativistic electromagnetic shock required for acceleration. One-dimensional (1D) Particle-In-Cell (PIC) simulations show that an electromagnetic shock driver with a given intensity can accelerate protons from 4.7 MeV to 13 GeV, driven by the transverse electric field induce by the compressed static magnetic field. These results suggest that this mechanism can be experimentally realized in magnetized laser-plasma systems, offering a novel approach for studying astrophysical phenomena in controlled laboratory experiments.}, archive = {J_ADVS}, author = {Ting Xiao and Xiaomei Zhang and Fanqiu Kong and Xiaolong Zheng and Zheng Gong and Baifei Shen}, doi = {10.1002/advs.202503538}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03538}, shortjournal = {Adv. Sci.}, title = {Proton acceleration with relativistic electromagnetic shock}, volume = {12}, year = {2025}, }
• (2025). Mechanotransduction activates microglia and impairs phagocytosis in stiff amyloid-β plaques. ADVS, 12(30), e03389. (www)

  @article{ , abstract = {In Alzheimer's disease (AD), microglia are activated by mechanical and biochemical cues in the amyloid-β (Aβ) plaque-associated microenvironment, causing neuroinflammation. While the impact of Aβ stiffness on microglial activation and the dynamic interplay between inflammation and phagocytosis remain unclear. Here, an in vitro Aβ plaque-associated microglia microenvironment model is built and investigated how the stiffness of Aβ plaques triggers microglial activation via the PIEZO1 mechanotransduction pathway. Scanning electrochemical microscopy and scanning ion conductance microscopy are employed to in situ monitor reactive oxygen species release, membrane permeability, and phagocytic activity of microglia. It is found that Aβ stiffness drives early microglial activation, forming an oxidative-stressed microenvironment that impairs the membrane integrity of microglia. And the antioxidant-resveratrol effectively improves the phagocytosis dysfunction of the impaired microglia. This work reveals the complex interplay among mechanical cues, neuroinflammation, and phagocytic dysfunction in microglia and suggests potential therapeutic strategies targeting microglial dysfunction in AD.}, archive = {J_ADVS}, author = {Yulin Liu and Junjie Zhang and Yuxiang Zhao and Feixiang Fang and Siyu Zhang and Qiqi An and Jian Zhuang and Feng Xu and Fei Li}, doi = {10.1002/advs.202503389}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03389}, shortjournal = {Adv. Sci.}, title = {Mechanotransduction activates microglia and impairs phagocytosis in stiff amyloid-β plaques}, volume = {12}, year = {2025}, }
• (2025). Solid state defect emitters with no electrical activity. ADVS, 12(30), e03350. (www)

  @article{ , abstract = {Point defects may introduce defect levels into the fundamental bandgap of the host semiconductors that alter the electrical properties of the material. As a consequence, the in-gap defect levels and states automatically lower the threshold energy of optical excitation associated with the optical gap of the host semiconductor. It is, therefore, a common assumption that solid-state defect emitters in semiconductors ultimately alter the conductivity of the host. This study demonstrate, on a particular defect in 4H silicon carbide, that an unrecognized class of point defects exists that are optically active but electrically inactive in the ground state.}, archive = {J_ADVS}, author = {Pei Li and Song Li and Péter Udvarhelyi and Bing Huang and Adam Gali}, doi = {10.1002/advs.202503350}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03350}, shortjournal = {Adv. Sci.}, title = {Solid state defect emitters with no electrical activity}, volume = {12}, year = {2025}, }
• (2025). Designing spin symmetry for altermagnetism with strong magnetoelectric coupling. ADVS, 12(30), e03235. (www)

  @article{ , abstract = {Altermagnets, a recently identified class of collinear magnets, exhibit unique properties such as zero net magnetization and spin polarization dictated by lattice symmetry, making them a subject of intense research. In contrast to conventional strategies for inducing altermagnetism in antiferromagnets that rely on manipulating real-space symmetry, this work introduces a novel and general approach to achieving altermagnetism by modulating spin-space symmetry. Through a combination of tight-binding models and first-principles calculations, the microscopic origin of altermagnetism driven by spin-space symmetry is uncovered, and the mechanism underlying enhanced spin splitting is identified. Furthermore, it is demonstrated that this spin-space modulation can synergistically interact with ferroelectricity, enabling a spin symmetry-dependent magnetoelectric coupling mechanism that is distinct from conventional multiferroics. This unique coupling is validated by the magneto-optical Kerr effect, providing a robust theoretical foundation for the development of next-generation spintronic devices that harness the potential of altermagnetism.}, archive = {J_ADVS}, author = {Wei Sun and Wenxuan Wang and Changhong Yang and Shifeng Huang and Ning Ding and Shuai Dong and Zhenxiang Cheng}, doi = {10.1002/advs.202503235}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03235}, shortjournal = {Adv. Sci.}, title = {Designing spin symmetry for altermagnetism with strong magnetoelectric coupling}, volume = {12}, year = {2025}, }
• (2025). Accelerating sono-piezoelectric charge transport for antibacterial therapy and bone regeneration by metal-deficient TiO2 spin-polarization effect. ADVS, 12(30), e03186. (www)

  @article{ , abstract = {Sonodynamic therapy (SDT) is recognized as an effective method for treating deep tissue bacterial infections, but enhancing charge transfer to achieve efficient SDT remains a formidable challenge. Here, deficient TiO 2 (DTO) is fabricated and Barium titanate (BTO) heterojunction with oxygen vacancies (OVs) and abundant Ti 3+ species on a Ti substrate. The OVs in DTO not only narrow the band gap of TiO 2 but also expedite the transfer of surrounding electrons to Ti 3+ . Meanwhile, the spin-polarization effect induced by the unpaired spin electrons in Ti atoms can expedite the transfer of ultrasonic piezoelectric charges in BTO, enhancing surface sonocatalytic efficiency. Consequently, the DTO/BTO with US irradiation can eradicate 99.82% of Staphylococcus aureus and inhibit biofilm formation. Additionally, the microcurrent generated by ultrasound-excited DTO/BTO enhanced mitochondrial fusion and promoted osteoblastic differentiation. The successful application of this ultrasound-mediated DTO/BTO in treating bone infection defects offers an effective antibiotic-free therapeutic strategy for deep-seated infections.}, archive = {J_ADVS}, author = {Chaofeng Wang and Shuilin Wu and Congyang Mao and Liguo Jin and Hanpeng Liu and Yufeng Zheng and Chunyong Liang and Shengli Zhu and Zhaoyang Li and Hui Jiang and Xiangmei Liu}, doi = {10.1002/advs.202503186}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03186}, shortjournal = {Adv. Sci.}, title = {Accelerating sono-piezoelectric charge transport for antibacterial therapy and bone regeneration by metal-deficient TiO2 spin-polarization effect}, volume = {12}, year = {2025}, }
• (2025). A human engineered heart tissue-derived lipotoxic diabetic cardiomyopathy model revealed early benefits of empagliflozin. ADVS, 12(30), e03173. (www)

  @article{ , abstract = {Diabetic cardiomyopathy (DbCM) is increasingly prevalent, but intervention targets remain unclear due to the lack of appropriate models and the complexity of risk factors. Here, this work establishes an in vitro assessment system for DbCM function using cardiomyocytes derived from human pluripotent stem cells and engineered heart tissue. This work finds high-fat status in complex diabetes risk factors majorly contributes most to cardiomyocyte death and contractile dysfunction. Notably, PA induced early electrophysiological abnormalities, and lately is associated with cardiac fibrosis, mitochondrial fission, and systolic and diastolic dysfunction at tissue level. Using this in vitro assessment system, this work finds that empagliflozin (EMPA), a first-line glucose-lowering drug, effectively alleviated early PA-induced cardiomyocyte injury. Treatment with EMPA enhanced abnormal diastolic and electrophysiological functions in the PA-hEHT model and significantly reduced endoplasmic reticulum stress, and apoptosis. Furthermore, these promising results are confirmed in a type 2 diabetes mellitus mouse model, reinforcing the potential of EMPA as a therapeutic option to alleviate cardiomyocyte injury under diabetic conditions. These findings suggest that this work has developed an engineered model of diabetic cardiomyopathy that mimics the various stages of lipotoxic myocardial injury and support the use of EMPA as a potential therapeutic option for diabetic or lipotoxic cardiomyopathy.}, archive = {J_ADVS}, author = {Lin Cai and Yuxin Zhao and Zilong Li and Liping Xiao and Yifan Wu and Shiya Wang and Qian Liu and Yida Ye and Yuxuan Guo and Donghui Zhang}, doi = {10.1002/advs.202503173}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03173}, shortjournal = {Adv. Sci.}, title = {A human engineered heart tissue-derived lipotoxic diabetic cardiomyopathy model revealed early benefits of empagliflozin}, volume = {12}, year = {2025}, }
• (2025). Machine learning-enhanced nanoparticle design for precision cancer drug delivery. ADVS, 12(30), e03138. (www)

  @article{ , abstract = {In recent years, nanomedicine has emerged as a promising approach to deliver therapeutic agents directly to tumors. However, despite its potential, cancer nanomedicine encounters significant challenges. The synthesis of nanomedicines involves numerous parameters, and the complexity of nano–bio interactions in vivo presents further difficulties. Therefore, innovative approaches are needed to optimize nanoparticle (NP) design and functionality, enhancing their delivery efficiency and therapeutic outcomes. Recent advancements in Machine Learning (ML) and computational methods have shown great promise for precision cancer drug delivery. This review summarizes the potential use of ML across all stages of NP drug delivery systems, along with a discussion of ongoing challenges and future directions. The authors first examine the synthesis and formulation of NPs, highlighting how ML can accelerate the process by searching for optimal synthesis parameters. Next, they delve into nano–bio interactions in drug delivery, including NP–protein interactions, blood circulation, NP extravasation into the tumor microenvironment (TME), tumor penetration and distribution, as well as cellular internalization. Through this comprehensive overview, the authors aim to highlight the transformative potential of ML in overcoming current challenges, assisting nanoscientists in the rational design of NPs, and advancing precision cancer nanomedicine.}, archive = {J_ADVS}, author = {Qingquan Wang and Yujian Liu and Chenchen Li and Bin Xu and Shidang Xu and Bin Liu}, doi = {10.1002/advs.202503138}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03138}, shortjournal = {Adv. Sci.}, title = {Machine learning-enhanced nanoparticle design for precision cancer drug delivery}, volume = {12}, year = {2025}, }
• (2025). DeepTFBS: Improving within- and cross-species prediction of transcription factor binding using deep multi-task and transfer learning. ADVS, 12(30), e03135. (www)

  @article{ , abstract = {The precise prediction of transcription factor binding sites (TFBSs) is crucial in understanding gene regulation. In this study, deepTFBS, a comprehensive deep learning (DL) framework that builds a robust DNA language model of TF binding grammar for accurately predicting TFBSs within and across plant species is presented. Taking advantages of multi-task DL and transfer learning, deepTFBS is capable of leveraging the knowledge learned from large-scale TF binding profiles to enhance the prediction of TFBSs under small-sample training and cross-species prediction tasks. When tested using available information on 359 Arabidopsis TFs, deepTFBS outperformed previously described prediction strategies, including position weight matrix, deepSEA and DanQ, with a 244.49%, 49.15%, and 23.32% improvement of the area under the precision-recall curve (PRAUC), respectively. Further cross-species prediction of TFBS in wheat showed that deepTFBS yielded a significant PRAUC improvement of 30.6% over these three baseline models. deepTFBS can also utilize information from gene conservation and binding motifs, enabling efficient TFBS prediction in species where experimental data availability is limited. A case study, focusing on the WUSCHEL ( WUS ) transcription factor, illustrated the potential use of deepTFBS in cross-species applications, in our example between Arabidopsis and wheat. deepTFBS is publically available at https://github.com/cma2015/deepTFBS .}, archive = {J_ADVS}, author = {Jingjing Zhai and Yuzhou Zhang and Chujun Zhang and Xiaotong Yin and Minggui Song and Chenglong Tang and Pengjun Ding and Zenglin Li and Chuang Ma}, doi = {10.1002/advs.202503135}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03135}, shortjournal = {Adv. Sci.}, title = {DeepTFBS: Improving within- and cross-species prediction of transcription factor binding using deep multi-task and transfer learning}, volume = {12}, year = {2025}, }
• (2025). High-performance rechargeable lithium-chlorine batteries with ALD conformal starburst porous graphene positive electrodes. ADVS, 12(30), e03113. (www)

  @article{ , abstract = {Rechargeable alkali metal-chlorine batteries are emerging as a promising high-energy-density solution. However, they confront significant challenges, including the primary issue stemming from the weak binding affinity of cathode materials for Cl 2 , which leads to a sluggish and inadequate supply of Cl 2 during the redox reactions, resulting in a shortened cycle life and low Coulombic efficiency (CE), particularly when operating at ultrahigh specific capacity outputs. Herein, an Al 2 O 3 -skinned heterostructured starburst porous graphene with conformal metasurfaces (Al 2 O 3 @rGO) is reported, crafted from a hierarchical porous starburst graphene arranged in a unique layered structure by the PTFE microemulsion skin effect, leveraging subsequent fluidized bed atomic layer deposition (FBALD) of Al 2 O 3 groups. Al 2 O 3 @rGO features superhydrophilicity, effective adsorption, fast kinetics from stable dynamic respiratory interface, high electrical and thermal conductivity anisotropy, intelligent thermal management and safe operation over a wide temperature range. Consequently, the Li-Cl 2 @Al 2 O 3 @rGO battery achieves an ultrahigh discharge specific capacity of 5000 mAh g −1 at ≈100% CE, and even delivers stable cycling over 200 cycles with 2000 mAh g −1 at an average CE of 99.8% under low temperature environment of -40 °C. The scalable heterostructure approach offers a sustainable perspective of the development of functionalized metamaterials and metasurfaces for next-generation safe and energy-dense batteries and broader applications.}, archive = {J_ADVS}, author = {Zhuo Yang and Yanan Huang and Weicheng Zhou and Hong Fan and Zhihao Ding and Xu Yan and Yu Lu and Alexander S. Sigov and Wei Huang and Lijun Gao and Cheng Huang}, doi = {10.1002/advs.202503113}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e03113}, shortjournal = {Adv. Sci.}, title = {High-performance rechargeable lithium-chlorine batteries with ALD conformal starburst porous graphene positive electrodes}, volume = {12}, year = {2025}, }
• (2025). HLA-DR⁺ tumor cells show an association with a distinct immune microenvironment and CD8⁺ T-cell exhaustion in HBV-associated hepatocellular carcinoma. ADVS, 12(30), e02979. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with hepatitis B virus (HBV) as a major driver. Despite the pivotal role of viral infections in shaping the tumor microenvironment (TME), the mechanistic differences among HBV-, hepatitis C virus (HCV)-, and non-B non-C (NBNC)-associated HCC remain poorly understood. By integrating the largest publicly available single-cell RNA sequencing (scRNA-seq) dataset of HCC (160 samples from 124 patients) with multi-scale protein-level validation using multiplex immunofluorescence and tissue microarrays (198 HCC specimens), HLA-DR⁺ tumor cells are identified as a distinctive feature of HBV + HCC. These tumor cells uniquely express MHC class II molecules, typically restricted to antigen-presenting cells, and correlate with immune checkpoint activation and PD-L1 expression, potentially contributing to an immunosuppressive microenvironment specific to HBV + HCC. Trajectory analysis revealed distinct CD8⁺ T-cell differentiation pathways in HBV + HCC, characterized by enhanced exhaustion and stem-like phenotypes. HLA-DR⁺ tumor cells are associated with increased recruitment of CD8⁺ T cells and correlated with T-cell exhaustion, potentially contributing to a suppressive TME. Clinically, high proportions of HLA-DR⁺ tumor cells are linked to poor survival outcomes, especially when accompanied by elevated PD-L1 expression, suggesting that HLA-DR⁺ tumor cells may serve as a potential predictive biomarker for immunotherapy efficacy in HCC. Collectively, the findings highlight HLA-DR⁺ tumor cells as a distinctive feature of HBV-associated HCC (HBV + HCC), providing novel insights into possible immunosuppressive mechanisms and therapeutic targets for immunotherapy in this disease context.}, archive = {J_ADVS}, author = {Jun-Qing Chang and Yan Guo and Wen-Jing Yuan and Yu-Man Chen and Bo-Wei Liu and Wen-Tao Li and Xiang-Ming Ding and Xu-Dong Fu and Yu-Han Lou and Zhuo-Ran Chen and Xiao-Ying Luo and Song-Ze Ding and Bing-Yong Zhang and Xiu-Ling Li and Yong-Zhi Hong and Shun-Dong Cang and Dong-Xiao Li and Ling Lan}, doi = {10.1002/advs.202502979}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02979}, shortjournal = {Adv. Sci.}, title = {HLA-DR⁺ tumor cells show an association with a distinct immune microenvironment and CD8⁺ T-cell exhaustion in HBV-associated hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Phosphorus vacancy-induced built-in electric field for electromagnetic properties modulation. ADVS, 12(30), e02857. (www)

  @article{ , abstract = {Anion vacancy engineering represents an effective strategy to construct built-in electric fields (BIEFs) for the purpose of modulating electromagnetic (EM) properties. However, the in-depth and systematic comparative analysis of the effects of various anionic vacancies on defect-induced polarization is still lacking. In this work, the effects of defect-induced polarization resulting from group VA anion vacancies, particularly phosphorus vacancies (V P ), are compared to the anion vacancies of other elements. The EM property modulation mechanisms and quantitative structure-property relations of NiCo 0.5 Fe 0.5 P 1-x with varying contents of V P are investigated. It is concluded that the high content of V P establishes more intense BIEFs, forming permanent induced dipoles that function as polarization centers, thus enhancing defect-induced polarization and improving permittivity and dielectric loss. NiCo 0.5 Fe 0.5 P 1-x3 with a high content of V P exhibits significant reflection loss (RL) with multi-band compatibility and wide effective absorption bandwidth (EAB) covering the whole X-band. This work offers a constructive perspective on the exploration of anionic vacancies from group VA, particularly V P , in modulating EM properties. Additionally, it addresses the issue of incompatibility associated with multi-band strong microwave absorption (MA) and offers a viable strategy for designing advanced metal phosphide MA materials.}, archive = {J_ADVS}, author = {Yu Zhang and Pengfei Hu and Pei-Yan Zhao and Bo Cai and Hualong Peng and Shu-Hao Yang and Martin C. Koo and Chenming Liang and Guang-Sheng Wang}, doi = {10.1002/advs.202502857}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02857}, shortjournal = {Adv. Sci.}, title = {Phosphorus vacancy-induced built-in electric field for electromagnetic properties modulation}, volume = {12}, year = {2025}, }
• (2025). In situ assembly of fluorogenic RNA for screening natural anti-liver fibrosis products via dynamic visualization of COL1A1 mRNA. ADVS, 12(30), e02850. (www)

  @article{ , abstract = {Liver fibrosis, a critical precursor to cirrhosis and a leading cause of mortality, highlights the urgent need for the identification of effective therapeutics. Activation of hepatic stellate cells (HSCs) is a key process in liver fibrosis. This study presents a live-cell drug-screening approach that specifically targets fibrosis-associated collagen type I alpha 1 ( COL1A1 ) mRNA in activated HSCs through the use of fluorogenic RNA self-assembly. It employs a dual-probe system to construct an RNA Mango II structure, which upon binding with COL1A1 mRNA, facilitates activation of the TO1-Biotin fluorophore, thereby enabling the visualization of mRNA to indicate HSC activation levels. Through the application of a high throughput live-cell screening system, dihydrotanshinone I (DHT) is identified as potent leading antifibrotic compound, evidenced by its inhibitory effects on COL1A1 mRNA expression. The therapeutic efficacy of DHT is further substantiated by monitoring COL1A1 mRNA dynamics following treatment. In vivo studies demonstrates the sustained administration of DHT significantly ameliorated liver fibrosis in mice models. This method offers a simple, cost-effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the development of hepatic fibrosis therapies.}, archive = {J_ADVS}, author = {Rui Bai and Li-Zeng Zhu and Changfa Shao and Zheng Yin and Qun Liu and Yu Gu and Bin Liu}, doi = {10.1002/advs.202502850}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02850}, shortjournal = {Adv. Sci.}, title = {In situ assembly of fluorogenic RNA for screening natural anti-liver fibrosis products via dynamic visualization of COL1A1 mRNA}, volume = {12}, year = {2025}, }
• (2025). Mechanistic foundations of KRAS-driven tumor ecosystems: Integrating crosstalk among immune, metabolic, microbial, and stromal microenvironment. ADVS, 12(30), e02714. (www)

  @article{ , abstract = {Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most frequently mutated member of the RAS family of small GTPases (RAS). It affects about one-fifth of cancer cases. The tumor microenvironment (TME) is a multifaceted network of immune cells, metabolites, microbiota, stromal components, and extracellular matrix. It creates a dynamic ecosystem that supports malignant initiation, progression, and therapy resistance through bidirectional crosstalk with tumor cells. Emerging evidence reveals distinct TME landscapes shaped by wild-type versus oncogenic KRAS variants. Additionally, TME rewiring occurs during KRAS-targeted therapies. Deciphering these KRAS-dependent TME architectures and their therapeutic vulnerabilities represents a critical frontier for precision oncology. This review synthesizes key milestones and persistent challenges in KRAS inhibitor development. And it systematically evaluates how KRAS mutations orchestrated immunosuppressive niches, metabolic symbiosis, stromal remodeling, and microbiome dysbiosis, supported by mechanistic insights from preclinical and clinical studies. It further explores therapeutic opportunities arising from targeting TME interactions, including rational combinations of KRAS inhibitors with immune checkpoint blockade, metabolic agents, or microbiota-modulating strategies.}, archive = {J_ADVS}, author = {Jiayao Ma and Shenao Fu and Jun Tan and Ying Han and Yihong Chen and Xiangying Deng and Hong Shen and Shan Zeng and Yinghui Peng and Changjing Cai}, doi = {10.1002/advs.202502714}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02714}, shortjournal = {Adv. Sci.}, title = {Mechanistic foundations of KRAS-driven tumor ecosystems: Integrating crosstalk among immune, metabolic, microbial, and stromal microenvironment}, volume = {12}, year = {2025}, }
• (2025). Highly stretchable, self-healable, and conductive gelatin methacryloyl hydrogel for long-lasting wearable tactile sensors. ADVS, 12(30), e02678. (www)

  @article{ , abstract = {Constructing hydrogels with both remarkable mechanical and self-healing properties is highly desirable for soft electronics, yet remains challenging due to conflicting demands on chemical bonds and polymer chain mobility. Herein, a highly stretchable, self-healing, and conductive gelatin methacryloyl (GelMA) hydrogel is developed by incorporating polyvinyl alcohol, N-(2-amino-2-oxoethyl)-2-propenamide, sodium tetraborate, and sodium chloride into GelMA, followed by a two-step polymerization process. The introduced novel interpenetrating networks, hierarchical hydrogen bonds (weak and strong H-bonds), and borate ester bonds (BEBs) synergistically improve the mechanical strength, and concurrently function as sacrificial bonds for energy dissipation under deformation. Moreover, the constructed reversible BEBs and weak H-bonds enable autonomous self-healing at room temperature. The resulting hydrogel achieves remarkable stretchability (≈160%), tensile strength (≈130 kPa), and self-healing efficiency (86%), surpassing previously reported GelMA hydrogels. Importantly, a self-healing GelMA hydrogel strain sensor is demonstrated, featuring a high gauge factor (≈3.28), ultra-low detection limit (0.1%), and excellent recovery of sensitivity (≈100%) and detection range (≈75%) after damage. Successful monitoring of subtle and large-scale human motions with both original and healed sensors highlights the device's durability and longevity. This study provides a promising approach for the rational design and practical application of GelMA hydrogels in wearable bioelectronics.}, archive = {J_ADVS}, author = {Zhikang Li and Bin Wang and Jijian Lu and Yumeng Xue and Jiaxiang Wang and Boqing Jia and Gengyu Han and Yihe Zhao and Muhammad Afzal Khan Qureshi and Lan Yu and Kang Zhao and Min Li and Ping Yang and Dejiang Lu and Libo Zhao}, doi = {10.1002/advs.202502678}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02678}, shortjournal = {Adv. Sci.}, title = {Highly stretchable, self-healable, and conductive gelatin methacryloyl hydrogel for long-lasting wearable tactile sensors}, volume = {12}, year = {2025}, }
• (2025). Small extracellular vesicles orchestrate cisplatin-induced ototoxicity: Potential biomarker and targets discovery. ADVS, 12(30), e02627. (www)

  @article{ , abstract = {Cisplatin-induced ototoxicity remains a clinical dilemma with limited mechanistic understanding and no food and drug administration (FDA)-approved therapies. Despite emerging roles of small extracellular vesicles (sEV) in drug ototoxicity, their molecular cargo profiles and causal roles to cisplatin-induced ototoxicity are unexplored. This study systematically investigates sEV derived from cochlear explants treated with cisplatin (Cis-sEV) and controls (Ctrl-sEV) using multi-omics profiling. Through small RNA sequencing, 83 differentially expressed microRNAs (miRNAs) are identified in Cis-sEV compared to Ctrl-sEV. Notably, mmu-miR-34a-5p, mmu-miR-140-5p, mmu-miR-15b-5p, mmu-miR-25-3p, and mmu-miR-339-5p are significantly upregulation in Cis-sEVs. Predicted target pathways of these differentially expressed miRNAs are enriched in apoptosis, inflammation, and cellular damage, indicating their potential involvement in cisplatin-induced cochlear damage. LC-MS/MS analysis reveals 90 upregulated and 150 downregulated proteins in Cis-sEV, with many involved in damage response. Specifically, CLTC, CCT2, ANXA6, and HSPA8 are uniquely upregulated proteins in Cis-sEV, and CLTC and ANXA6 are exclusively co-localized in hair cells (HCs) post-cisplatin exposure, suggesting that Cis-sEV originate primarily from damaged HCs. Moreover, CLTC in sEV may serve as a potential biomarker for cisplatin-induced ototoxicity as verified in both in vitro and in vivo models. This study provides novel insights into the molecular mechanisms of cisplatin-induced ototoxicity and identifies potential biomarker and therapeutic targets.}, archive = {J_ADVS}, author = {Jingru Ai and Shasha Zhang and Mingchen Dai and Pei Jiang and Jingyuan Huang and Hairong Xiao and Yanqin Lin and Xujun Tang and Wei Tong and Jun He and Qiuyue Mao and Yintao Wang and Zixuan Ye and Tian Wang and Renjie Chai}, doi = {10.1002/advs.202502627}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02627}, shortjournal = {Adv. Sci.}, title = {Small extracellular vesicles orchestrate cisplatin-induced ototoxicity: Potential biomarker and targets discovery}, volume = {12}, year = {2025}, }
• (2025). A full-range proximity-tactile sensor based on multimodal perception fusion for minimally invasive surgical robots. ADVS, 12(30), e02353. (www)

  @article{ , abstract = {Minimally invasive surgical robots have received widespread attention due to its numerous advantages. However, the lack of adequate perception capability remains a significant issue for the robots. In this work, a full-range proximity-tactile sensing module has been developed for safe operation of surgical robots, which performs multimodal fusion perception through ultrasonic sensor for long-range proximity detection, capacitive sensor for close-range proximity sensing, and triboelectric sensor for tactile sensing. In order for a minimum sensor size, the ultrasonic sensor is developed based on MEMS piezoelectric micromachined ultrasonic transducers (pMUTs), and the capacitive sensor and triboelectric sensor adopt common structures, which collaborate to achieve accurate proximity-tactile perception. Additionally, a wireless vibration feedback wristband and digital-twin interface are developed to provide multimodal feedback without interfering with operation. Experimental results demonstrates the safety enhancement for surgical robots by the perception and feedback system. Furthermore, the sensing module is applied in preliminary detection of subcutaneous abnormal tissues and the identification accuracy based on the ultrasound echoes and convolutional neural networks is 91.6%, which can provide an initial diagnostic reference. The full-range proximity-tactile sensor holds significant potential for enhancing the safety and detection capability of surgical robots, and promoting the intelligence of robot-assisted minimally invasive surgery.}, archive = {J_ADVS}, author = {Dongsheng Li and Tianci Ji and Yuyang Sun and Zhongbin Zhang and Aomen Li and Mengjiao Qu and Dongze Lv and Jin Xie and Huicong Liu}, doi = {10.1002/advs.202502353}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02353}, shortjournal = {Adv. Sci.}, title = {A full-range proximity-tactile sensor based on multimodal perception fusion for minimally invasive surgical robots}, volume = {12}, year = {2025}, }
• (2025). Harnessing bifunctional nitrogen-dislocation interactions for a record ultra-strong-and-ductile duplex titanium alloy. ADVS, 12(30), e02349. (www)

  @article{ , abstract = {Duplex (α+β) Ti alloys often manifest limited uniform elongation (ε u ) mainly originating from the lack of < c + a > dislocations for insufficient work hardening capability and semi-coherent α/β interfaces for strain incompatibility. The strength–ductility trade-off of duplex Ti alloys is further amplified by interstitial atoms-poisoning effects (e.g., N and O). Here, by selecting N atoms with the strongest hardening ability in Ti alloys, a counterintuitive strategy is proposed that harnesses bifunctional N-dislocation interactions in a model duplex Ti–Cr–Zr–Al alloy to construct a heterogeneous lamella structure, involving the elongated α p grains decorated with N-rich low-angle grain boundaries (LAGBs) and densely coherent interstitial-N α′-nanotwinned martensites in β-grains. This structural heterogeneity achieves extremely high yield/tensile strength of ≈1532/1869 MPa in our alloys, which in turn promotes the emission of massive < c + a > dislocations from N-rich LAGBs and coherent interfaces through stress-activated bow-out and cross-slip processes for relatively large ε u ≈10.2%. This work thus opens an avenue, via bifunctional interstitial atom-dislocation interactions, to construct a unique microstructure, toward ultrahigh strength and large ductility in interstitial-strengthening Ti alloys.}, archive = {J_ADVS}, author = {Chongle Zhang and Xuanzhe Li and Suzhi Li and Jinyu Zhang and Gang Liu and Jun Sun}, doi = {10.1002/advs.202502349}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02349}, shortjournal = {Adv. Sci.}, title = {Harnessing bifunctional nitrogen-dislocation interactions for a record ultra-strong-and-ductile duplex titanium alloy}, volume = {12}, year = {2025}, }
• (2025). Nano-oil-barrier-based fluttering triboelectric nanogenerator. ADVS, 12(30), e02278. (www)

  @article{ , abstract = {In the field of triboelectric nanogenerators (TENGs), the application of a thin lubricant layer on the contact surface and its maintenance for long-term cycling remain important challenges for improving the mechanical-electrical stability of TENGs. Herein, a simple and innovative approach is proposed to solve this dilemma using commercial oil-absorbing sheets and oil infusion steps. In particular, a wind-driven nano-oil-barrier-based fluttering triboelectric nanogenerator (NF-TENG) is developed. The nano-oil barrier (of nanoscale thickness) of NF-TENG is thoroughly analyzed using atomic force microscopy imaging and electrical-mechanical measurement/calculation results. Compared with other control groups, only NF-TENG maintains 95% output performance from 100% initial output performance, and device damage is minimized even after 970,000 cycles. The mechanism of NF-TENG and its differences from previous studies are established. NF-TENG is optimized and studied for various design variables and wind speeds. NF-TENG generated a peak power of 468 µW with 100 Hz and an average power of 166 µW at optimum load resistance, under a breeze wind speed of 6 m s −1 . NF-TENG demonstrates its applications in two real-life scenarios: 1) wind harvesting at a rooftop vent pipe for outdoor temperature-humidity sensing, and 2) wind harvesting during bicycle riding for safety light illumination.}, archive = {J_ADVS}, author = {Deokjae Heo and Jiwoong Hur and Hyeonho Cho and Kyunghwan Cha and Jaeung Choi and Moonhyun Choi and Jinkee Hong and Sunghan Kim and Sangmin Lee}, doi = {10.1002/advs.202502278}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02278}, shortjournal = {Adv. Sci.}, title = {Nano-oil-barrier-based fluttering triboelectric nanogenerator}, volume = {12}, year = {2025}, }
• (2025). High pressure restrains the photo-induced polyhedra distortion in 0D antimony-based metal halide. ADVS, 12(30), e02189. (www)

  @article{ , abstract = {Recently, dual emission phenomena based on excitation-dependent emission are increasingly observed in 0D antimony-based metal halides. However, the origins of these two emissions remain debated. Herein, high pressure is employed to investigate the structural-optical relationship of the typical 0D antimony-based metal halides (TTA) 2 SbCl 5 (TTA = tetraethylammonium) and uncover mechanisms behind its emission. As pressure increases, the dual emission of (TTA) 2 SbCl 5 under 303 nm excitation, characterized by high energy and low energy emission peaks, transitions to a single low energy emission peak at ≈5.7 GPa. Meanwhile, a single broadband emission peak excited by 355 nm maintains a distinct low energy emission peak throughout the compression process, exhibiting an excitation-dependent emission color response. Combining experiment results with density functional theory calculations, the observed phenomenon is attributed to pressure restrain of photo-induced distortion in the [SbCl 5 ] 2 ⁻ polyhedra in (TTA) 2 SbCl 5 . These finding reveals the relationship between the local structure and excitation-dependent emission, providing new perspectives and insights into the modulation of Sb-based metal halides.}, archive = {J_ADVS}, author = {Jiaxiang Wang and Lingrui Wang and Weiqi Yuan and Yifang Yuan and Fei Wang and Kai Wang and Haizhong Guo}, doi = {10.1002/advs.202502189}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02189}, shortjournal = {Adv. Sci.}, title = {High pressure restrains the photo-induced polyhedra distortion in 0D antimony-based metal halide}, volume = {12}, year = {2025}, }
• (2025). Inhibiting FAT1 blocks metabolic bypass to enhance antitumor efficacy of TCA cycle inhibition through suppressing CPT1A-dependent fatty acid oxidation. ADVS, 12(30), e02146. (www)

  @article{ , abstract = {FAT atypical cadherin 1 ( FAT1 ) is one of the most frequently mutated genes in head and neck squamous cell carcinoma (HNSCC), exhibiting the highest mutation rate across different tumor types. Although FAT1's role has attracted considerable attention, its impact on cancer metabolism and treatment resistance remains poorly understood. In this study, it is demonstrated that knockout of mutant FAT1 in HNSCC cells attenuates CPT1A-driven fatty acid oxidation (FAO) through downregulation of the transcription factor ASCL2, leading to marked suppression of tumor growth. Notably, FAT1 -mutant HNSCC cells exhibit resistance to the TCA cycle inhibitor CPI-613 through activation of CPT1A-mediated FAO, whereas genetic ablation of mutant FAT1 restores sensitivity to CPI-613. To achieve in vivo depletion of FAT1 , LNP-sgFAT1 is developed, a novel lipid nanoparticle (LNP) system encapsulating Cas9 mRNA and FAT1 -targeting sgRNA. In murine models bearing FAT1 -mutant head and neck tumors, LNP-sgFAT1 demonstrated enhanced antitumor activity when combined with CPI-613. Collectively, these findings establish that mutant FAT1 drives CPT1A-dependent FAO, facilitating a metabolic bypass that confers resistance to TCA cycle inhibition in HNSCC. This mechanistic insight highlights promising opportunities for combinatorial therapeutic strategies co-targeting genetic and metabolic vulnerabilities in cancer.}, archive = {J_ADVS}, author = {Fanghui Chen and Jianqiang Yang and David O. Popoola and Fan Yang and Yajie Liu and Dongsheng Wang and Zhaohui S. Qin and Zhengjia Chen and Nabil F. Saba and Zhuo G. Chen and Yamin Li and Yong Teng}, doi = {10.1002/advs.202502146}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e02146}, shortjournal = {Adv. Sci.}, title = {Inhibiting FAT1 blocks metabolic bypass to enhance antitumor efficacy of TCA cycle inhibition through suppressing CPT1A-dependent fatty acid oxidation}, volume = {12}, year = {2025}, }
• (2025). RSPO2 coordinates with GDF9:BMP15 heterodimers to promote granulosa cell and oocyte development in mice. ADVS, 12(30), e01973. (www)

  @article{ , abstract = {The generation of mature oocytes, a cornerstone of reproduction, relies on the coordinated interactions between oocytes and surrounding follicular somatic cells. Central to this process is the bidirectional communication between the oocyte and granulosa cells, mediated by oocyte-secreted factors (OSFs), including GDF9 and BMP15. While GDF9 and BMP15 are well-established regulators of oocyte and follicle development, the role of additional OSFs and their coordination with GDF9 and BMP15 remains largely unclear. Here, RSPO2 is identified as a key OSF that coordinates with the GDF9:BMP15 heterodimer to regulate granulosa cell development and enhance oocyte competence. RSPO2, primarily expressed in oocytes, interacts with GDF9:BMP15 to preserve transcriptomic integrity in preantral granulosa cells. This coordination is gene-specific, exhibiting either synergistic or antagonistic effects depending on the target genes, and involves crosstalk between CTNNB1- and SMAD2-dependent pathways. Conditional knockout of Rspo2 in oocytes causes severe defects in granulosa cell and oocyte development, leading to subfertility and earlier reproductive lifespan termination. Transcriptomic analysis shows that RSPO2 loss disrupts key granulosa cell genes (e.g., Amh, Ccnd2, Inhbb, Kitl ) and compromises oocyte mitochondrial function, reducing developmental competence. These findings establish RSPO2 as an essential factor in the oocyte-granulosa cell regulatory loop, crucial for ovarian function and fertility.}, archive = {J_ADVS}, author = {Yingmei Wang and Hongjiang Li and Liji You and Shuhui Wang and Jinglei Bie and Ziyang Su and Lanying Shi and You-Qiang Su}, doi = {10.1002/advs.202501973}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e01973}, shortjournal = {Adv. Sci.}, title = {RSPO2 coordinates with GDF9:BMP15 heterodimers to promote granulosa cell and oocyte development in mice}, volume = {12}, year = {2025}, }
• (2025). A novel OsMPK6-OsMADS47-PPKL1/3 module controls grain shape and yield in rice. ADVS, 12(30), e01946. (www)

  @article{ , abstract = {Grain shape is a key determinant of both grain yield and appearance quality in rice. However, the interactions among different regulatory pathways remain unclear. Here, a novel regulatory axis centered on a MADS-box transcription factor (TF) OsMADS47 for controlling rice grain shape is reported. OsMADS47 overexpression results in slender grains, whereas knockout leads to short and small grains. OsMADS47 acts downstream of the OsMKKK10-OsMKK4-OsMPK6 cascade and can be phosphorylated by OsMPK6. Phosphorylation stabilizes OsMADS47 and enhances its transcriptional repression activities on target genes GS3 and GW8 , two well-known grain shape regulators. Meanwhile, the Kelch-repeat protein phosphatase PPKL1/3 can dephosphorylate OsMADS47, making it unstable and releasing the transcriptional repression on target genes. Knockdown of OsMPK6 or overexpression of PPKL1/3, GS3 , or GW8 partially suppresses the slender-grain phenotype of the Os MADS47 overexpression plants. The results establish an integrated regulation pathway of grain shape and prove the hub gene OsMADS47 as a potential target for breeding rice with optimized appearance quality.}, archive = {J_ADVS}, author = {Jingjing Fang and Yan Chun and Fan Zhang and Tingting Guo and Mengmeng Ren and Jinfeng Zhao and Shoujiang Yuan and Wensheng Wang and Yunhai Li and Xueyong Li}, doi = {10.1002/advs.202501946}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e01946}, shortjournal = {Adv. Sci.}, title = {A novel OsMPK6-OsMADS47-PPKL1/3 module controls grain shape and yield in rice}, volume = {12}, year = {2025}, }
• (2025). Multifunctional infrared polarizer based on aligned growth of high-density boron nitride nanotubes. ADVS, 12(30), e01908. (www)

  @article{ , abstract = {Boron nitride nanotubes (BNNTs) are an emerging mid-infrared optical material that exhibits significant potential in nanoscale resonators, lasers, detectors, and sensors due to the strong light-matter interactions induced by phonon polaritons (PhPs). However, the large-scale controllable synthesis and device applications of BNNTs still face huge challenges. In this study, a substrate-pretreated and boron source dual-catalyst infiltrated growth method, and a damage-free purification method toward the high-density and aligned BNNT (ABNNT) thin films is developed. The polarization sensitivity and linear dichroism characteristics of BNNTs with a maximum anisotropy ratio of 4.53 in the mid-infrared and near-infrared regions are comprehensively verified. The nanotube-alignment induced permittivity anisotropy outside RB and the near-isotropic PhP absorption within RB enable a wavelength-selective polarizer and absorber throughout a broad infrared range. Uniquely, the BNNT polarizer exhibits excellent stability of polarization dichroism under severe bending conditions, demonstrating great potential in flexible and wearable optical devices. This work can initiate the utilization of high-density BNNT thin films in quantum information processing and high-resolution infrared imaging applications.}, archive = {J_ADVS}, author = {Ningqiang Shi and Xiaofei Xiao and Mingyu Zhang and Zhijun Li and Chuncheng Ban and Jinchang Meng and Nannan Shi and Mingyang Wu and Zebo Zheng and Ling Li}, doi = {10.1002/advs.202501908}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e01908}, shortjournal = {Adv. Sci.}, title = {Multifunctional infrared polarizer based on aligned growth of high-density boron nitride nanotubes}, volume = {12}, year = {2025}, }
• (2025). Bispecific antibody targeting VEGF/TGF-β synergizes with local radiotherapy: Turning tumors from cold to inflamed and amplifying abscopal effects. ADVS, 12(30), e01819. (www)

  @article{ , abstract = {Beyond inherently killing cancer cells by directly inducing double-strand DNA breaks, local radiotherapy (RT) can exert immune-priming effects and reprogram the tumor microenvironment (TME) from immune-cold tumors into inflamed, or “hot” tumors. Nevertheless, this immunogenic antitumor response may be partially counterbalanced by the upregulation of vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-β) induced by RT. Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF-β, effectively synergized with RT, leading to a durable antitumor effect. Mechanistically, Y332D counteracted negative RT effects that are attributed to the upregulation of TGF-β and VEGF-mediated epithelial-mesenchymal transition, extracellular matrix remodeling, aberrant angiogenesis, immunosuppression, and radioresistance, as well as further enhanced or complemented the positive effects of RT, such as cGAS-STING activation, immunogenic cell death, enhanced antigen presentation, increased T cell infiltration, and antiangiogenic effects, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in-situ vaccine that, beyond local tumor eradication, could potentiate antitumor immune response and regress preestablished abscopal metastases. Together, our results indicate that this combination strategy successfully overcame the negative effects caused by RT and augmented abscopal effects, extending the application of RT to the treatment of both local and metastatic disease.}, archive = {J_ADVS}, author = {Lijuan Lyu and Ming Yi and Ji Chen and Jing Zhang and Xiaobin Ma and Xiaojun Zhang and Liang Zeng and Yan Xue and Haimei Wen and Yujiao Deng and Pengfei Zhou and Kongming Wu and Huafeng Kang and Zhijun Dai}, doi = {10.1002/advs.202501819}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e01819}, shortjournal = {Adv. Sci.}, title = {Bispecific antibody targeting VEGF/TGF-β synergizes with local radiotherapy: Turning tumors from cold to inflamed and amplifying abscopal effects}, volume = {12}, year = {2025}, }
• (2025). Inhibition and rescue of hyperglycemia-induced cellular senescence by mitochondrial transfer from enucleated mesenchymal stem cell-derived microvesicles for chronic wound healing. ADVS, 12(30), e01612. (www)

  @article{ , abstract = {The aberrant cellular senescence in chronic wounds presents a significant barrier to healing. Mitochondrial dysfunction is critical in initiating and maintaining cellular senescence, underscoring therapeutic potential in restoring mitochondrial function by delivering healthy mitochondria to wound cells. However, approaches for delivering mitochondria to achieve optimized wound repair remain lacking. Herein, enucleated MSCs-derived microvesicles containing functional mitochondria (Mito@euMVs) via simple extrusion are developed. By controlling the size of microvesicles within a small micron-scale range, the mitochondrial encapsulation efficiency is optimized. Mito@euMVs effectively delivered mitochondria into fibroblasts and HUVECs, inhibiting and rejuvenating hyperglycemia-induced cellular senescence. To enhance the clinical applicability, soluble PVA microneedle patches for the transdermal Mito@euMVs delivery are utilized. In diabetic rats with pressure sores, the senescence-inhibiting and -rescuing properties of Mito@euMVs are further validated, along with their therapeutic efficacy, demonstrating their potential for chronic wound repair. Moreover, as a versatile delivery vehicle for mitochondria, Mito@euMVs hold promising for treating mitochondrial dysfunction and aging-related conditions.}, archive = {J_ADVS}, author = {Zixuan Dong and Xiaobing Liu and Shichun Li and Xiaoling Fu}, doi = {10.1002/advs.202501612}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e01612}, shortjournal = {Adv. Sci.}, title = {Inhibition and rescue of hyperglycemia-induced cellular senescence by mitochondrial transfer from enucleated mesenchymal stem cell-derived microvesicles for chronic wound healing}, volume = {12}, year = {2025}, }
• (2025). Targeting GPX4 to induce ferroptosis overcomes chemoresistance mediated by the PAX8-AS1/GPX4 axis in intrahepatic cholangiocarcinoma. ADVS, 12(30), e01042. (www)

  @article{ , abstract = {The standard regimen of gemcitabine combined with cisplatin offers limited clinical benefits in the treatment of advanced intrahepatic cholangiocarcinoma (ICC) due to intrinsic or acquired resistance. Currently, effective biomarkers to predict and improve chemotherapy resistance in ICC are lacking. Here, it is reported that a long non-coding RNA (lncRNA), PAX8-AS1 , reduces the efficacy of standard chemotherapeutic drugs. Mechanistically, PAX8-AS1 activates NRF2 by binding to p62, thereby promoting GPX4 transcription, and stabilizes GPX4 mRNA through interaction with IGF2BP3. The PAX8-AS1 /GPX4 axis inhibits ferroptosis and promotes resistance to gemcitabine and cisplatin. In preclinical models, the combination of the GPX4 inhibitor JKE-1674 with gemcitabine and cisplatin exhibits superior antitumor efficacy. These findings suggest a promising therapeutic strategy to improve chemotherapy efficacy in advanced ICC.}, archive = {J_ADVS}, author = {Zhi-Wen Chen and Ji-Jun Shan and Mo Chen and Zong Wu and Yi-Ming Zhao and Hong-Xu Zhu and Xin Jin and Yi-Xiu Wang and Yi-Bin Wu and Zhen Xiang and Zhi-Wen Ding and Zhen-Hai Lin and Long-Rong Wang and Lu Wang}, doi = {10.1002/advs.202501042}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e01042}, shortjournal = {Adv. Sci.}, title = {Targeting GPX4 to induce ferroptosis overcomes chemoresistance mediated by the PAX8-AS1/GPX4 axis in intrahepatic cholangiocarcinoma}, volume = {12}, year = {2025}, }
• (2025). Single-cell analysis reveals that vitamin c inhibits bone metastasis of renal cancer via cell cycle arrest and microenvironment remodeling. ADVS, 12(30), e01011. (www)

  @article{ , abstract = {Bone metastasis is the second most common site of distant metastatic spread in renal cell carcinoma (RCC) patients, significantly contributing to cancer-related mortality. The metastatic process is driven by both intrinsic tumor cell properties, such as cancer stem cell-like characteristics, and the bone microenvironment. Understanding the complex interactions between cancer cells and their niche is crucial for identifying therapeutic targets to eliminate metastasis-initiating cells and prevent overt metastasis. In this study, a murine bone metastasis model is developed using renal cancer cells derived from fibrin gel-induced 3D tumor spheres, which exhibit stem-like phenotypes. It is found that a stable form of vitamin C, L-ascorbic acid 2-phosphate sesquimagnesium (APM), significantly inhibits the growth of renal cancer stem-like cells in vitro and the progression of RCC bone metastasis in vivo. Single-cell RNA sequencing revealed that APM induces cell cycle arrest and reduces the metastatic potential of cancer cells. Furthermore, APM remodels the tumor microenvironment by suppressing osteoclast differentiation and neutrophil recruitment. Combining APM with a CXCR2 antagonist, SB225002, further inhibits bone metastasis progression. This study provides a high-resolution profile of vitamin C's antitumor effects in the bone metastatic microenvironment and supports the rationale for clinical trials of vitamin C in bone metastatic RCC.}, archive = {J_ADVS}, author = {Jianye Zhang and Qi Zhang and Gang Lin and Ying Wang and Juan Li and Ping Wang and Jie Qi and Yuan Liang and Shiming He and Yanqing Gong and Ninghan Feng and Yang Wang and Yuanyuan Ma and Mei Zhang and Yue Shi and Xuesong Li and Weimin Ci and Liqun Zhou}, doi = {10.1002/advs.202501011}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e01011}, shortjournal = {Adv. Sci.}, title = {Single-cell analysis reveals that vitamin c inhibits bone metastasis of renal cancer via cell cycle arrest and microenvironment remodeling}, volume = {12}, year = {2025}, }
• (2025). Instant writing of conductive interface on MOF single crystal by ultrafast laser. ADVS, 12(30), e00711. (www)

  @article{ , abstract = {Single crystals with excellent properties have been widely used in electronics industries due to their homogeneous and consistent structures. Metal-organic frameworks (MOFs), as a class of crystalline materials that can be synthetically tuned for functionality, are expected to be a favorable candidate for novel electronic devices. However, there is still a lack of methods to efficiently fabricate conductive patterns at the single-crystal scale. Here, laser instant writing of in situ continuous conductive interface on MOF single crystals is reported, enabling the patterning and continuous fabrication of conductive interface at the single-crystal scale. Carbon-wrapped Cu nanoparticles (Cu@C NPs) conductive interface is instantly written using a 1030 nm picosecond ultrafast laser on large HKUST-1 single crystals. It is found that different thermal accumulations can affect the conductivity of Cu@C and transformation of matter phase from Cu NPs to Cu 2 O on single crystals is observed as the ablation of carbonaceous materials. As a validation, single-crystal sensor with interdigitated electrodes (IDEs) constructed by laser interface technique shows a wide response range of 5%–90% RH and a fast response time of 2 s toward humidity sensing. This method sheds new light on the construction of functional interface on single MOF crystal, providing a novel strategy for MOF-based electronics.}, archive = {J_ADVS}, author = {Dongsheng Huang and Shuailong Guo and Peng Chen and Yanan Liu and Zhenhua Wang and Ye Ding and Hao Li and Huijun Wu and Zhiyuan Ma and Haoqing Jiang and Lijun Yang and Hongxing Xu}, doi = {10.1002/advs.202500711}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e00711}, shortjournal = {Adv. Sci.}, title = {Instant writing of conductive interface on MOF single crystal by ultrafast laser}, volume = {12}, year = {2025}, }
• (2025). Local charge density enhancement strategy in nitrogen-rich covalent organic framework for boosted iodine removal from water. ADVS, 12(30), e00697. (www)

  @article{ , abstract = {The leakage of nuclear pollution highlights the critical importance of effectively separating radioactive pollutants. Radioactive iodine, a high-yield fission product of nuclear reactions, poses serious environmental and health risks. However, the lack of efficient adsorbents makes the management of aqueous radioactive iodine pollution a significant challenge. N-doped materials are among the most recognized adsorbents for iodine removal, but their weak binding affinity and limited number of iodine-binding N-sites hinder their practical application. Herein, a covalent organic framework (COFs) named phen-TPA is synthesized, featuring an increased number and optimized local chemical environment of iodine-binding N-sites. This material demonstrates record-breaking iodine removal kinetics, with a kinetic constant of 14.64 g g −1 min −1 for aqueous iodine (I 2 ), and the highest-reported iodine adsorption capacity of 11.9 g g −1 for aqueous triiodide (I 3 − ). Large-scale flow-through adsorption experiments show that phen-TPA can remove 99.5% aqueous I 2 and I 3 − from high-salinity aqueous environments, highlighting its potential for practical applications.}, archive = {J_ADVS}, author = {Yue Ma and Jinjiao Pan and Huazhen Rong and Lu Liu and Yilei Zhang and Xuewen Cao and Jiacheng Zhang and Tao Liu and Ning Wang and Yihui Yuan}, doi = {10.1002/advs.202500697}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e00697}, shortjournal = {Adv. Sci.}, title = {Local charge density enhancement strategy in nitrogen-rich covalent organic framework for boosted iodine removal from water}, volume = {12}, year = {2025}, }
• (2025). Resolving artifacts in voltage-clamp experiments with computational modeling: An application to fast sodium current recordings. ADVS, 12(30), e00691. (www)

  @article{ , abstract = {Cellular electrophysiology underpins fields from basic science in neurology, cardiology, and oncology to safety critical applications for drug safety testing, risk assessment of rare mutations, and models based on cellular electrophysiology data even guide clinical interventions. Patch-clamp voltage clamp is the gold standard for measuring ionic current dynamics that explain cellular electrophysiology, but recordings can be influenced by artifacts introduced by the measurement process. A computational approach is developed, validated through electrical model cell experiments, to explain and predict intricate artifacts in voltage-clamp experiments. Applied to various cardiac fast sodium current measurements, the model resolved artifacts in the experiments by coupling observed current with simulated membrane voltage, explaining some typically observed shifts and delays in recorded currents. It is shown that averaging data for current-voltage relationships can introduce biases comparable to effect sizes reported for disease-causing mutations. The computational pipeline provides improved assessment and interpretation of voltage-clamp experiments, correcting, and enhancing understanding of ion channel behavior.}, archive = {J_ADVS}, author = {Chon Lok Lei and Alexander P. Clark and Michael Clerx and Siyu Wei and Meye Bloothooft and Teun P. de Boer and David J. Christini and Trine Krogh-Madsen and Gary R. Mirams}, doi = {10.1002/advs.202500691}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e00691}, shortjournal = {Adv. Sci.}, title = {Resolving artifacts in voltage-clamp experiments with computational modeling: An application to fast sodium current recordings}, volume = {12}, year = {2025}, }
• (2025). Hosts and commensal bacteria synergistically antagonize opportunistic pathogens at the single-cell resolution. ADVS, 12(30), e00582. (www)

  @article{ , abstract = {Natural microbes coexist in a diverse species population with competition for space and nutrient resources. However, the molecular mechanisms underpinning the regulatory networks of microbes among themselves and with their host are still in infancy. Here, it is reported that Drosophila and the commensal Lactiplantibacillus plantarum form an alliance to compete with the pathogenic Serratia marcescens using the integrated three-species model system. In the dual-species model, larvae diminish the L. plantarum population, but reversibly increase lactate production through altering its transcriptional reprogramming. In the tripartite-species model, larvae facilitate the growth of L. plantarum that confers colonization resistance against S. marcescens . On the other hand, S. marcescens launches sophisticated arms race strategies to impair colonization resistance by sensing lactate derived from L. plantarum . More importantly, the S. marcescens population challenged with Drosophila and L. plantarum adaptively diverge into virulent and reduced virulence subclusters with an increase in resistance heterogeneity. To form the alliance with Drosophila , heterogeneity in lactate generation is broadened among L. plantarum subpopulations. Altogether, these findings provide an insight into the host-commensal-pathogen symbiosis at both bulk and single-cell resolutions, advancing fundamental concepts of precise manipulation of bacterial communities.}, archive = {J_ADVS}, author = {Sheng Zhang and Ziguang Wang and Anqi Liu and Jinshu Li and Jingjing Zhuang and Xiaowen Ji and Paul I. Mulama and Maoye Li and Haiqun Cao and Eng-King Tan and Wei Liu}, doi = {10.1002/advs.202500582}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e00582}, shortjournal = {Adv. Sci.}, title = {Hosts and commensal bacteria synergistically antagonize opportunistic pathogens at the single-cell resolution}, volume = {12}, year = {2025}, }
• (2025). ACSS2-mediated histone h4 lysine 12 crotonylation (H4K12cr) alleviates colitis via enhancing transcription of CLDN7. ADVS, 12(30), e00461. (www)

  @article{ , abstract = {Histone lysine crotonylation (Kcr), a highly conserved posttranslational modification, plays critical roles in various biological processes. Nevertheless, the dynamic alterations and functions of histone Kcr in inflammatory bowel disease (IBD) remain poorly explored. Herein, a notable decrease of both Pan-Kcr and ACSS2 (acyl-CoA synthetase short-chain family member 2), the key enzyme for crotonyl-CoA generation, is revealed in inflamed intestinal epithelial cells. Genetic or pharmacological inhibition of ACSS2 dramatically impairs mouse intestinal barrier integrity and exacerbates colitis. Mechanistically, ACSS2-mediated histone H4 lysine 12 crotonylation (H4K12cr) upregulates CLDN7 expression to fortify intestinal epithelial barrier, which can be augmented by crotonate supplementation. Furthermore, tumor necrosis factor-α (TNF-α) is revealed to enhance the m6A modification of ACSS2 mRNA, consequently destabilizing and downregulating ACSS2 . Combinational therapy involving anti-TNF-α and crotonate can significantly ameliorate colitis. Overall, ACSS2-mediated H4K12cr emerges as a pivotal modulator governing intestinal barrier function during IBD progression.}, archive = {J_ADVS}, author = {Ming Yuan and Shaopeng Chen and Zhensen Lin and Runfeng Yu and Kang Chao and Shubiao Ye and Qing Li and Haoxian Ke and Chi Zhang and Junfeng Huang and Guanzhan Liang and Tuo Hu and Xiang Gao and Ping Lan and Xianrui Wu}, doi = {10.1002/advs.202500461}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e00461}, shortjournal = {Adv. Sci.}, title = {ACSS2-mediated histone h4 lysine 12 crotonylation (H4K12cr) alleviates colitis via enhancing transcription of CLDN7}, volume = {12}, year = {2025}, }
• (2025). Nanoparticle-mediated CXCL12–CXCR4 inhibition reprograms macrophages and suppresses gastric carcinoma. ADVS, 12(30), e00225. (www)

  @article{ , abstract = {Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches. This study investigates the efficacy of self-assembled M2pep-Cs NPs/Plerixafor nanoparticles in suppressing GC by targeting the CXCL12–CXCR4 signaling pathway and reprogramming tumor-associated macrophages (TAMs) to enhance anti-tumor immunity. The nanoparticles’ physicochemical properties and biocompatibility are assessed using transmission electron microscopy, dynamic light scattering, and biological assays. A GC mouse model is established, followed by histological and immunohistochemical analyses to evaluate tumor apoptosis and proliferation. Multi-omics approaches, including transcriptomics, proteomics, and metabolomics, identify key genes and pathways affected by treatment. Flow cytometry and ELISA quantify immune activation markers; while, cell migration and invasion assays evaluate tumor suppression effects. The results demonstrate that M2pep-Cs NPs/Plerixafor effectively modulates the tumor microenvironment, suppressing GC progression by reprogramming TAMs through CXCL12–CXCR4 inhibition, enhancing immune recognition and T cell responses. This study provides mechanistic insights and highlights the potential of nanoparticle-based immunotherapy for GC, offering a promising avenue for clinical translation.}, archive = {J_ADVS}, author = {Qianqian Cao and Xiaolei Cheng and Rongbin Lv and Dianshui Sun and Jihua Wang and Runjia Fu and Rumei Gong and Yueying Xiao and Qin Liu and Xiaomei Li}, doi = {10.1002/advs.202500225}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {e00225}, shortjournal = {Adv. Sci.}, title = {Nanoparticle-mediated CXCL12–CXCR4 inhibition reprograms macrophages and suppresses gastric carcinoma}, volume = {12}, year = {2025}, }
• (2025). Nanofabricated bacterial cell walls with intrinsic peroxidase-mimicking and sonodynamic activities for cancer combination treatment. ADVS, 12(30), 2505310. (www)

  @article{ , abstract = {Bacterial cancer therapy recently has been attracting more and more attention because of its multiple functions to fight cancer. Porphyromonas gingivalis (Pg), a Gram-negative pathogenic bacterium, acquires protoporphyrin IX (PpIX) and iron from heme and synthesizes abundant µ-oxo bisheme on its cell walls (CWs). For the first time, it is found that the CWs extracted from Pg has intrinsic peroxidase (POD)-mimicking and sonodynamic activities owing to the presence of µ-oxo bisheme. In this study, the CWs of Pg are nanofabricated to form the CW vesicles (CWV) containing a large amount of lipopolysaccharide (LPS) and further encapsulated doxorubicin (DOX) to prepare DOX-loaded CWV (DOX@CWV), hoping to eradicate cancer by combining sonodynamic therapy (SDT), chemotherapy, and bacterial immunotherapy. The results confirmed that DOX@CWV can catalyze the conversion of H 2 O 2 into O 2 and consume the reduced glutathione (GSH), and thus greatly boost their own sonodynamic performance upon ultrasonic irradiation. Both in vitro and in vivo, DOX@CWV efficiently inhibited cancer growth by combining SDT and chemotherapy, and also exerted synergistic anticancer immune effects of bacterial immunotherapy and SDT. In summary, the findings not only contribute a promising bacterial therapeutic agent but also provide a combination strategy for clinical cancer treatment.}, archive = {J_ADVS}, author = {Meng Yang and Yang Meng and Junling Li and Liya Bai and Yuanyuan Cheng and Yuanyuan Liu and Mingxin Cao and Xiaoying Yang and Yinsong Wang and Yang Liu}, doi = {10.1002/advs.202505310}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {2505310}, shortjournal = {Adv. Sci.}, title = {Nanofabricated bacterial cell walls with intrinsic peroxidase-mimicking and sonodynamic activities for cancer combination treatment}, volume = {12}, year = {2025}, }
• (2025). Bioinspired claw-engaged adhesive microparticles armed with γGC alleviate ulcerative colitis via targeted suppression of macrophage ferroptosis. ADVS, 12(30), 2503903. (www)

  @article{ , abstract = {Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by focal iron overload. Herein, we reported that γ-glutamylcysteine (γGC) deletion in UC lesions intensified the disease by depleting intracellular GSH to induce macrophage ferroptosis, leading to macrophage M1 reprogramming and eventually exacerbating inflammation. To counteract this, the advanced microparticles (MPs)-based delivery system is selected to encapsulate γGC. The resulting γGC-MPs displayed the same porous and spiky morphology as their substrate's natural pollens, resulting in improved intestinal adhesion and enhanced lesion contact of γGC-MPs. Our results demonstrated that exogenous γGC supplementation could inhibit macrophage M1 polarization by restraining ferroptosis, as well as suppressing the PI3K/AKT pathway and TNF signaling pathway. Compared with free γGC, γGC-MPs significantly alleviated typical UC symptoms in dextran sulfate sodium (DSS)-induced colitis, evidenced by reduced intestinal inflammation, restored intestinal barrier function, and improved microbiota composition. Consequently, this study addressed critical gaps in understanding the causes of ferroptosis and its impact on macrophage reprogramming in UC, offering a novel synergistic therapeutic strategy for UC.}, archive = {J_ADVS}, author = {Rong Wang and Jianwei Zhu and Jinyi Zhou and Jinyang Li and Min Wang and Yuqi Wu and Danshan Zhao and Xiancheng Chen and Xiaoyuan Chen and Yuetong Wang and Jianhua Zou}, doi = {10.1002/advs.202503903}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {2503903}, shortjournal = {Adv. Sci.}, title = {Bioinspired claw-engaged adhesive microparticles armed with γGC alleviate ulcerative colitis via targeted suppression of macrophage ferroptosis}, volume = {12}, year = {2025}, }
• (2025). AI-driven defecation analysis by smart healthcare toilet: Exploring biometric patterns and eu-tenesmus. ADVS, 12(30), 2503247. (www)

  @article{ , abstract = {Defecation, a fundamental physiological process, remains underexplored despite its importance in human health. To address this gap, a smart toilet system is developed that enables real-time monitoring of defecation behaviors. Analyzing 45 defecation events from 11 participants, key defecation parameters are identified, including stool dropping duration, stool thickness, and eu-tenesmus interval. Stool dropping duration follows a log-normal distribution, with longer durations (>5 s) linked to lower Bristol Stool Form Scale (BSFS) scores, suggesting constipation ( p = 0.008 for BSFS1/2/3 vs BSFS5/6/7). Stool thickness decreases with increasing BSFS scores ( p = 5 × 10⁻⁶ for BSFS1/2/3 vs BSFS5/6/7), validating its role as an objective marker for bowel function. Eu-tenesmus is introduced, defined as the interval between the last stool drop and cleansing, averaging 74.8 s. It shows significant gender differences ( p = 0.014) but no correlation with stool consistency, suggesting its potential as an independent biomarker for gut health. Defecation behaviors between humans and animals is also compared in detail. Longitudinal monitoring demonstrates the potential for personalized health tracking and dietary recommendations. Furthermore, the feasibility of biometric identification is established using 11 defecation-related parameters, including stool properties and cleansing behavior. These features enable high participant differentiation, supporting non-invasive identity verification.}, archive = {J_ADVS}, author = {Zhiquan Song and TaeHyung Kwon and Jeung Lee and Daeyoun D. Won and Brian J. Lee and Hyuk Soon Choi and Joseph C. Liao and Walter G. Park and Irene Sonu and Stephan Rogalla and Michael J. Rosen and David L. Hu and Jonathan Kuang Ziyang and Sunny Hei Wong and Bong Hyun Jun and Soh Kim and Seung-min Park}, doi = {10.1002/advs.202503247}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {2503247}, shortjournal = {Adv. Sci.}, title = {AI-driven defecation analysis by smart healthcare toilet: Exploring biometric patterns and eu-tenesmus}, volume = {12}, year = {2025}, }
• (2025). Gradient solvent replacement-mediated formation of high-strength hydrogel-forming microneedle for long-term drug delivery. ADVS, 12(30), 2500833. (www)

  @article{ , abstract = {The microneedle, a minimally invasive transdermal system, provides a convenient and painless method for drug delivery. Among the various types of microneedles, hydrogel-forming microneedles (HFMs) demonstrate distinct advantages in terms of high-dose drug loading and biocompatibility. However, HFMs usually require drying to obtain sufficient puncture strength, which may destroy drug activity and increase storage costs. Herein, a high-strength HFM patch with pH-responsiveness for post-drug loading and long-term release is developed based on acrylonitrile-acrylic acid copolymer. The dipole-dipole and hydrogen bonding interactions formed through gradient solvent replacement are evenly distributed within the cross-linked network, significantly enhancing the mechanical properties of the hydrogel required for epidermal penetration. The prepared hydrogel exhibits a tensile strength of 26 MPa and a Young's modulus of 407 MPa. The microneedles formed from this hydrogel display a single needle mechanical force of 1.18 N. The post-loading mode conferred by pH responsiveness allows the drug to be encapsulated in both the tips and the substrate, acting as a reservoir. Once applied to the skin, the microneedle is activated by body fluids to achieve long-term drug release. Overall, this high-strength HFM improves the mechanical properties in the hydrated state, making it a promising minimally invasive transdermal delivery platform.}, archive = {J_ADVS}, author = {Hui Li and Fengzhen Meng and Chengwei Hu and Zhiyun Wu and Liuzhi Hao and Caijun Sun and Lijing Fang and Fan Pan and Shaoquan Bian and Huipeng Li and Mingjun Li and Bo Liu and Xiaoli Zhao}, doi = {10.1002/advs.202500833}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {2500833}, shortjournal = {Adv. Sci.}, title = {Gradient solvent replacement-mediated formation of high-strength hydrogel-forming microneedle for long-term drug delivery}, volume = {12}, year = {2025}, }
• (2025). LincNEAT1 encoded-NEAT1-31 promotes phagocytosis by directly activating the aurora-A–PI3K–AKT pathway. ADVS, 12(30), 2413473. (www)

  @article{ , abstract = {Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation. Long non-coding ribonucleic acid nuclear enriched abundant transcript 1 ( LincNEAT1 ) is specifically translated during phagocytosis. Great efforts have been made to explore the potential mechanisms of action of these phagocytic checkpoints. However, the use of a systematic checkpoint scanning strategy has been far from satisfactory, and intrinsic phagocytic activators have not been fully elucidated. Therefore, in vitro phagocytosis assays are performed using primary healthy donor macrophages and breast cancer cells. An equal number of cells are subjected to ribosome profiling, and immune system-specific phagocytic activators are identified. LincNEAT1 and encoded micro peptide NEAT1-31, are considerably upregulated in phagocytic macrophages. Moreover, purified NEAT1-31 promoted the phagocytosis of multiple cancer cell-types. Phosphoproteomic analysis reveals that NEAT1-31 directly promoted Aurora-A activity and activated phosphatidylinositol 3-kinase/protein kinase B signaling. NEAT1-31 enhanced the efficacy of anti-CD47 in vivo and in vitro. Thus, the study identified a novel protein drug that can directly enhance the phagocytic function, thereby providing a new option for immunotherapy.}, archive = {J_ADVS}, author = {Jie Li and Jing Zhang and Xixi Li and Xin Liu and Bo Zeng and Jiayue Luo and Huijin Wang and Hanbing Zhang and Xinya Gao}, doi = {10.1002/advs.202413473}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {2413473}, shortjournal = {Adv. Sci.}, title = {LincNEAT1 encoded-NEAT1-31 promotes phagocytosis by directly activating the aurora-A–PI3K–AKT pathway}, volume = {12}, year = {2025}, }
• (2025). Colonic submucosa targeted delivery of probiotic and rhein for ulcerative colitis treatment. ADVS, 12(30), 2409711. (www)

  @article{ , abstract = {Ulcerative colitis (UC) is a chronic disease. A significant challenge for the management of UC is to achieve delivery of drugs to the multi-layer colonic barriers, as existing drugs are difficult to penetrate these depths. In this study, a novel drug delivery system using yeast cell wall microparticles (YPs) are developed to co-encapsulate Bacillus subtilis (BS) and Rhein (Rh) termed Rh-YBS. This system specifically targets colonic microfold cells, enabling direct delivery of BS to the colonic submucosa. Additionally, Rh enhances BS colonization in the submucosa through floral regulation. Studies indicate that Rh-YBS can effectively reach and proliferate within the submucosa in vivo. In a DSS-induced UC mouse model, Rh-YBS stimulates the CGRP-related neural pathway; BS activation in the submucosa leads to increased CGRP secretion, prompting goblet cells to secrete mucus and thereby repairing the mucosa. Furthermore, the Rh-YBS also provide a preventive benefit against UC. In summary, Rh-YBS represents an innovative drug delivery system for mucosal repair in UC treatment, activating a unique mechanism involving the CGRP-related neural pathway.}, archive = {J_ADVS}, author = {Lingqiang Li and Linxin Dai and Meisi Lin and Shuang He and Hongye Du and Dasheng Lin and Yanbin Wang and Fenglian Zhang and Sian Tao and Xiaoluo Sun and Xinggui Huang and Haihui Liu and Qian Wang and Lingling He and Kunhe Wu and Jieshu You and Minyue Zhang and Chaomei Fu and He Tu and Naijing Ye and Jibin Liu and Fei Gao}, doi = {10.1002/advs.202409711}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {2409711}, shortjournal = {Adv. Sci.}, title = {Colonic submucosa targeted delivery of probiotic and rhein for ulcerative colitis treatment}, volume = {12}, year = {2025}, }
• (2025). Stereotyped subclones revealed by high-density single-cell lineage tracing support robust development. ADVS, 12(30), 2406208. (www)

  @article{ , abstract = {Robust development is essential for multicellular organisms. While various mechanisms contributing to developmental robustness are identified at the subcellular level, those at the intercellular and tissue level remain underexplored. This question is approached using a well-established in vitro directed differentiation model recapitulating the in vivo development of lung progenitor cells from human embryonic stem cells. An integrated analysis of high-density cell lineage trees (CLTs) and single-cell transcriptomes of differentiating colonies enabled the resolution of known cell types and developmental hierarchies. This dataset showed little support for the contribution of transcriptional memory to developmental robustness. Nevertheless, stable terminal cell type compositions are observed among many subclones, which enhances developmental robustness because the colony can retain a relatively stable composition even if some subclones are abolished by cell death. Furthermore, it is found that many subclones are formed by sub-CLTs resembling each other in terms of both terminal cell type compositions and topological structures. The presence of stereotyped sub-CLTs constitutes a novel basis for developmental robustness. Moreover, these results suggest a unique perspective on individual cells' function in the context of stereotyped sub-CLTs, which can bridge the knowledge of the atlas of cell types and how they are organized into functional tissues.}, archive = {J_ADVS}, author = {Xiaoyu Zhang and Zizhang Li and Jingyu Chen and Wenjing Yang and Xingxing He and Peng Wu and Feng Chen and Ziwei Zhou and Chenze Ren and Yuyan Shan and Xiewen Wen and Vassily A. Lyubetsky and Leonid Yu. Rusin and Xiaoshu Chen and Jian-Rong Yang}, doi = {10.1002/advs.202406208}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {2406208}, shortjournal = {Adv. Sci.}, title = {Stereotyped subclones revealed by high-density single-cell lineage tracing support robust development}, volume = {12}, year = {2025}, }
• (2025). Lecithin alleviates memory deficits and muscle attenuation in chinese older adults and SAMP8 mice. ADVS, 12(30), 2405222. (www)

  @article{ , abstract = {Identifying the mechanistic targets of crosstalk between sarcopenia (SA) and mild cognitive impairment (MCI) is critical for screening high-risk populations and exploring effective prevention and treatment strategies. In a nationwide multicenter prospective cohort study combined with an RCT study, it is found that indexes of muscle health reveal a strong predictive relationship with cognitive performance assessed using the Montreal Cognitive Assessment (MoCA). Furthermore, Random Forest models suggest that lecithin can predict both diseases. Erythrocyte lipid analysis and RCT study indicate the protective function of lecithin and the potential involvement of irisin in that process. In rodent models, phosphocholine (PC) alleviates learning and memory impairments and muscle attenuation in SAMP8 mice, while FNDC5/irisin knockdown accelerates brain and muscle damage or eliminates the protective effects of PC. Transcriptome analysis shows that PGC1α (the regulator of FNDC5) is regulated by PC treatment, and the results of knocking out PGC1α and FNDC5/irisin are consistent. Here it is found that muscle-secreted FNDC5/irisin is a key target of “muscle-brain” crosstalk, and lecithin may postpone the progression of MCI and SA by stimulating PGC1α-FNDC5/irisin-mediated cross-protection of cognition and skeletal muscle.}, archive = {J_ADVS}, author = {Xianyun Wang and Dajun Li and Xiao Ying Li and Weizhao Lu and Huini Ding and Chengyan Qi and Xuan Wang and Jing Shen and Yafei Chi and Tiantian Li and Michelle M. Dunk and Yu An and Hongmei Huang and Kang Yu and Weili Xu and Rong Xiao and Yuandi Xi}, doi = {10.1002/advs.202405222}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {2405222}, shortjournal = {Adv. Sci.}, title = {Lecithin alleviates memory deficits and muscle attenuation in chinese older adults and SAMP8 mice}, volume = {12}, year = {2025}, }
• (2025). LincNEAT1 encoded-NEAT1-31 promotes phagocytosis by directly activating the aurora-A–PI3K–AKT pathway (Adv. sci. 30/2025). ADVS, 12(30), 71173. (www)

  @article{ , archive = {J_ADVS}, author = {Jie Li and Jing Zhang and Xixi Li and Xin Liu and Bo Zeng and Jiayue Luo and Huijin Wang and Hanbing Zhang and Xinya Gao}, doi = {10.1002/advs.71173}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71173}, shortjournal = {Adv. Sci.}, title = {LincNEAT1 encoded-NEAT1-31 promotes phagocytosis by directly activating the aurora-A–PI3K–AKT pathway (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). AI-driven defecation analysis by smart healthcare toilet: Exploring biometric patterns and eu-tenesmus (Adv. sci. 30/2025). ADVS, 12(30), 71162. (www)

  @article{ , archive = {J_ADVS}, author = {Zhiquan Song and TaeHyung Kwon and Jeung Lee and Daeyoun D. Won and Brian J. Lee and Hyuk Soon Choi and Joseph C. Liao and Walter G. Park and Irene Sonu and Stephan Rogalla and Michael J. Rosen and David L. Hu and Jonathan Kuang Ziyang and Sunny Hei Wong and Bong Hyun Jun and Soh Kim and Seung-min Park}, doi = {10.1002/advs.71162}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71162}, shortjournal = {Adv. Sci.}, title = {AI-driven defecation analysis by smart healthcare toilet: Exploring biometric patterns and eu-tenesmus (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). Lecithin alleviates memory deficits and muscle attenuation in chinese older adults and SAMP8 mice (Adv. sci. 30/2025). ADVS, 12(30), 71161. (www)

  @article{ , archive = {J_ADVS}, author = {Xianyun Wang and Dajun Li and Xiao Ying Li and Weizhao Lu and Huini Ding and Chengyan Qi and Xuan Wang and Jing Shen and Yafei Chi and Tiantian Li and Michelle M. Dunk and Yu An and Hongmei Huang and Kang Yu and Weili Xu and Rong Xiao and Yuandi Xi}, doi = {10.1002/advs.71161}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71161}, shortjournal = {Adv. Sci.}, title = {Lecithin alleviates memory deficits and muscle attenuation in chinese older adults and SAMP8 mice (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). Colonic submucosa targeted delivery of probiotic and rhein for ulcerative colitis treatment (Adv. sci. 30/2025). ADVS, 12(30), 71160. (www)

  @article{ , archive = {J_ADVS}, author = {Lingqiang Li and Linxin Dai and Meisi Lin and Shuang He and Hongye Du and Dasheng Lin and Yanbin Wang and Fenglian Zhang and Sian Tao and Xiaoluo Sun and Xinggui Huang and Haihui Liu and Qian Wang and Lingling He and Kunhe Wu and Jieshu You and Minyue Zhang and Chaomei Fu and He Tu and Naijing Ye and Jibin Liu and Fei Gao}, doi = {10.1002/advs.71160}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71160}, shortjournal = {Adv. Sci.}, title = {Colonic submucosa targeted delivery of probiotic and rhein for ulcerative colitis treatment (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). Stereotyped subclones revealed by high-density single-cell lineage tracing support robust development (Adv. sci. 30/2025). ADVS, 12(30), 71159. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaoyu Zhang and Zizhang Li and Jingyu Chen and Wenjing Yang and Xingxing He and Peng Wu and Feng Chen and Ziwei Zhou and Chenze Ren and Yuyan Shan and Xiewen Wen and Vassily A. Lyubetsky and Leonid Yu. Rusin and Xiaoshu Chen and Jian-Rong Yang}, doi = {10.1002/advs.71159}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71159}, shortjournal = {Adv. Sci.}, title = {Stereotyped subclones revealed by high-density single-cell lineage tracing support robust development (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). Nanofabricated bacterial cell walls with intrinsic peroxidase-mimicking and sonodynamic activities for cancer combination treatment (Adv. sci. 30/2025). ADVS, 12(30), 71158. (www)

  @article{ , archive = {J_ADVS}, author = {Meng Yang and Yang Meng and Junling Li and Liya Bai and Yuanyuan Cheng and Yuanyuan Liu and Mingxin Cao and Xiaoying Yang and Yinsong Wang and Yang Liu}, doi = {10.1002/advs.71158}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71158}, shortjournal = {Adv. Sci.}, title = {Nanofabricated bacterial cell walls with intrinsic peroxidase-mimicking and sonodynamic activities for cancer combination treatment (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). PlantGPT: An arabidopsis-based intelligent agent that answers questions about plant functional genomics (Adv. sci. 30/2025). ADVS, 12(30), 71157. (www)

  @article{ , archive = {J_ADVS}, author = {Ruixiang Zhang and Yu Wang and Weiyang Yang and Jun Wen and Weizhi Liu and Shipeng Zhi and Guangzhou Li and Nan Chai and Jiaqi Huang and Yongyao Xie and Xianrong Xie and Letian Chen and Miao Gu and Yao-Guang Liu and Qinlong Zhu}, doi = {10.1002/advs.71157}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71157}, shortjournal = {Adv. Sci.}, title = {PlantGPT: An arabidopsis-based intelligent agent that answers questions about plant functional genomics (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). Gradient solvent replacement-mediated formation of high-strength hydrogel-forming microneedle for long-term drug delivery (Adv. sci. 30/2025). ADVS, 12(30), 71156. (www)

  @article{ , archive = {J_ADVS}, author = {Hui Li and Fengzhen Meng and Chengwei Hu and Zhiyun Wu and Liuzhi Hao and Caijun Sun and Lijing Fang and Fan Pan and Shaoquan Bian and Huipeng Li and Mingjun Li and Bo Liu and Xiaoli Zhao}, doi = {10.1002/advs.71156}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71156}, shortjournal = {Adv. Sci.}, title = {Gradient solvent replacement-mediated formation of high-strength hydrogel-forming microneedle for long-term drug delivery (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). Bioinspired claw-engaged adhesive microparticles armed with γGC alleviate ulcerative colitis via targeted suppression of macrophage ferroptosis (Adv. sci. 30/2025). ADVS, 12(30), 71155. (www)

  @article{ , archive = {J_ADVS}, author = {Rong Wang and Jianwei Zhu and Jinyi Zhou and Jinyang Li and Min Wang and Yuqi Wu and Danshan Zhao and Xiancheng Chen and Xiaoyuan Chen and Yuetong Wang and Jianhua Zou}, doi = {10.1002/advs.71155}, journal = {Advanced Science}, month = {8}, number = {30}, pages = {71155}, shortjournal = {Adv. Sci.}, title = {Bioinspired claw-engaged adhesive microparticles armed with γGC alleviate ulcerative colitis via targeted suppression of macrophage ferroptosis (Adv. sci. 30/2025)}, volume = {12}, year = {2025}, }
• (2025). An electrode design strategy to minimize ferroelectric imprint effect. ADVS, 12(29), e70011. (www)

  @article{ , abstract = {The phenomenon of ferroelectric imprint, characterized by an asymmetric polarization switching behavior, poses significant challenges in the reliability and performance of ultra-low-voltage ferroelectric devices, including MagnetoElectric Spin-Orbit devices, Ferroelectric Random-Access Memory, Ferroelectric Field-Effect Transistors, and Ferroelectric Tunnel Junctions. In this study, the influence of electrode configuration in different device architectures are systematically investigated on their imprint effect. By tuning the work function of La 0.7 Sr 0.3 MnO 3 (LSMO) electrodes through oxygen pressure during deposition, precise control over the built-in voltage offset (V offset ) in ferroelectric capacitors are demonstrated. This results reveal that higher oxygen pressures increase the work function of LSMO, effectively compensating for V offset and enhancing device stability. Finally, a ferroelectric device with a hybrid bottom electrode of LSMO and SrRuO 3 is optimized to mitigate the imprint effect. The optimal device showcases small coercive voltage of 0.3 V, a minimal V offset of 0.06 V, excellent endurance (electrical cycle up to 10 9 ), and robust zero bias applied polarization retention. These findings provide a practical guideline for electrode design in ferroelectric devices, addressing the imprint effect and improving operational reliability. This approach, combining material tuning and in situ diagnostics, offers a pathway to optimize ferroelectric device performance, with implications for advancing ultra-low-power electronics.}, archive = {J_ADVS}, author = {Yu-Wei Chen and Tung-Yuan Yu and Chun-Wei Huang and Tzu-Hsuan Yu and Yung-Chi Su and Chao-Rung Chen and Wei-Chen Hung and Pei-Yin Chang and Bhagwati Prasad and Yu-Chuan Lin and Ramamoorthy Ramesh and Yen-Lin Huang}, doi = {10.1002/advs.70011}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e70011}, shortjournal = {Adv. Sci.}, title = {An electrode design strategy to minimize ferroelectric imprint effect}, volume = {12}, year = {2025}, }
• (2025). Prospect of cascade catalysis in magnesium-sulfur batteries from desolvation to conversion reactions. ADVS, 12(29), e70008. (www)

  @article{ , abstract = {Magnesium-sulfur (Mg-S) batteries have the advantages of high volumetric energy density, intrinsic safety, and low cost of anode and cathode materials. However, current obstacles that preventing practical applications of Mg-S batteries are reflected in the sluggish reaction kinetics of insulative sulfur cathode, designs of compatible electrolytes, and surface optimization of Mg anode against passivation. Regarding the sulfur cathodes, the inherent low conductivity, high volumetric changes, and polysulfide shuttling always result in depressive capacity and utilization. As known, the Mg 2+ carriers are coordinated with solvents in the electrolyte and need to be desolvated before or during the Mg 2+ participating in the electrochemical reactions. The desolvation steps and the cathodic or anodic redox steps are intercoupled at the electrode/electrolyte interface, which can be regarded as cascade reactions of different pathways. In this review, the efforts to deal with the high-energy-barrier processes including Mg 2+ desolvation, Mg 2+ migration at the interface and in cathode interior, and sulfur conversions are summarized. Importantly, the possible coupling manners between the above processes are highlighted. Then cascade catalysis strategy for accelerating the desolvation and sulfur conversion kinetics on the premise of superior conductivity is further reviewed along with a variety of characterizations from experiments to theoretical simulations. Finally, future development trends and deep understanding in Mg-S batteries are prospected.}, archive = {J_ADVS}, author = {Qinghua Guan and Jing Zhang and Yongzheng Zhang and Xiaomin Cheng and Jing Dong and Lujie Jia and Hongzhen Lin and Jian Wang}, doi = {10.1002/advs.70008}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e70008}, shortjournal = {Adv. Sci.}, title = {Prospect of cascade catalysis in magnesium-sulfur batteries from desolvation to conversion reactions}, volume = {12}, year = {2025}, }
• (2025). BAG2 inhibits cervical cancer progression by modulating type i interferon signaling through stabilizing STING. ADVS, 12(29), e70005. (www)

  @article{ , abstract = {Cervical cancer possesses high morbidity and mortality rates, and a comprehensive understanding of its molecular underpinnings is essential for advancing clinical management strategies. The innate immune sensor STING, which activates type I interferon signaling, plays a pivotal role in enhancing anti-tumor activity. Despite increased attention to STING's involvement in cervical cancer, the regulatory mechanisms governing its protein homeostasis remain poorly understood. In this study, it is found that the BAG2-STUB1 complex regulates ubiquitin proteasomal degradation of STING, which affects the development of cervical cancer. Mechanistically, BAG2 inhibits ubiquitination of STING and stabilizes it by interacting with STING. Specifically, BAG2 inhibits STUB1 from attaching the K48-linked ubiquitin chains at K338 and K370 of STING by forming a complex with STUB1. Functionally, enhanced BAG2 expression suppresses cervical cancer progression by activating the type I interferon pathway in a STING-dependent manner. Notably, clinical cervical cancer samples revealed a positive correlation between BAG2 and STING levels, with low BAG2 expression is strongly linked to advanced disease and poor prognosis in cervical cancer. Collectively, these findings elucidate the molecular mechanism by which the BAG2-STUB1 complex regulates STING homeostasis, underscoring BAG2's potential as a diagnostic biomarker and therapeutic target in cervical cancer.}, archive = {J_ADVS}, author = {Shijie Yao and Siming Chen and Anjin Wang and Ziyan Liang and Xuelian Liu and Yang Gao and Hongbing Cai}, doi = {10.1002/advs.202414637}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e70005}, shortjournal = {Adv. Sci.}, title = {BAG2 inhibits cervical cancer progression by modulating type i interferon signaling through stabilizing STING}, volume = {12}, year = {2025}, }
• (2025). Recent advances in mRNA delivery systems for cancer therapy. ADVS, 12(29), e17571. (www)

  @article{ , abstract = {mRNA therapy is a promising approach in oncology, offering innovative applications such as tumor vaccines, protein replacement therapy, cell therapy, and gene therapy. However, challenges such as mRNA stability and delivery efficiency must be addressed. Advances in delivery system technologies are crucial for precise mRNA delivery, enhancing treatment safety and efficacy. The development of delivery systems requires accurate organ or cell targeting, intelligent release mechanisms, and optimized administration routes. This review outlines the applications of mRNA therapy in oncology, as well as the utilization of nonviral vectors, encompassing organic, inorganic, and biomimetic systems. It further elucidates the strategies for passive and active vector targeting and examines recent advances in the realm of stimuli-responsive delivery systems that are sensitive to pH and ultrasound. Additionally, the review addresses the development of noninvasive mRNA delivery systems designed for oral and pulmonary administration. The current challenges and emerging trends of mRNA therapy are discussed, and the potential strategies to mitigate these issues are emphasized.}, archive = {J_ADVS}, author = {Zheng Zhang and Ya-Nan Fan and Si-Qi Jiang and Ya-Jing Ma and Yao-Ru Yu and Yu-Xin Qing and Qian-Ru Li and Yi-Lin Liu and Song Shen and Jun Wang}, doi = {10.1002/advs.202417571}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e17571}, shortjournal = {Adv. Sci.}, title = {Recent advances in mRNA delivery systems for cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Integrative single-cell analysis reveals iron overload-induced senescence and metabolic reprogramming in ovarian endometriosis-associated infertility. ADVS, 12(29), e17528. (www)

  @article{ , abstract = {Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE-associated infertility (OEI). A single-cell atlas of pre-ovulatory follicular fluid from OEI patients reveals dynamic changes in iron metabolism and iron-induced senescence phenotypes. Spatial transcriptomics using Stereo-seq in iron-overloaded mouse ovaries further identifies localized senescence features. Additional analysis of aging human ovaries highlights conserved patterns of iron dysregulation. These findings provide mechanistic insight into iron overload-related ovarian pathology and suggest potential therapeutic targets for improving oocyte quality in OEI.}, archive = {J_ADVS}, author = {Yangshuo Li and Wei Zhou and Jie Ding and Di Song and Wen Cheng and Jin Yu and Shuai Sun and Shanshan Mei and Xiaolan Liang and Qianqian Zhao and Yanping Kuang and Mingqing Li and Zhexin Ni and Chaoqin Yu and Yue Gao}, doi = {10.1002/advs.202417528}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e17528}, shortjournal = {Adv. Sci.}, title = {Integrative single-cell analysis reveals iron overload-induced senescence and metabolic reprogramming in ovarian endometriosis-associated infertility}, volume = {12}, year = {2025}, }
• (2025). Unassisted switchable dual-photoelectrode devices utilizing p-n carbon quantum dots as “Semiconductor electrolytes”: Optimization between H2O2 and solar electricity production. ADVS, 12(29), e17204. (www)

  @article{ , abstract = {Switchable self-driven photoelectrochemical (PEC) devices are developed to boost H 2 O 2 or electricity generation under visible-light illumination, in which p-n type carbon quantum dots (N-CQDs) is applied as conceptually-new “semiconductor electrolytes”. The N-CQDs contains N-dopants, and both negatively- and positively-charged surface groups. This allows N-CQDs to act as the electrolyte and to interact with both a BiVO 4 photoanode and a Cu 2 O photocathode. In a two-compartment cell with a separating membrane, N-CQDs can dynamically form p-n heterojunctions with the photoanode or the photocathode, facilitating charge separation. In this setup, the fine-tuned electronic structure of N-CQDs promotes the two-electron reactions with water or O 2 to produce H 2 O 2 , achieving a rate of 28 µ m min −1 and Faradic efficiency exceeding 80%. Switching into a one-compartment cell, N-CQDs promotes four-electron charge transfer and stabilizes the photoelectrodes, giving electricity output for over 120 h. This control over electron transfer, selectivity, and durability cannot be achieved using traditional electrolytes.}, archive = {J_ADVS}, author = {Hui-Min Duan and Chen-Guang Li and Liu-Meng Mo and Jing-Shuang Dang and Xiao-Hui Jia and Jia-Cheng Yu and Yu-Hang Mei and Anders Thapper and Hong-Yan Wang}, doi = {10.1002/advs.202417204}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e17204}, shortjournal = {Adv. Sci.}, title = {Unassisted switchable dual-photoelectrode devices utilizing p-n carbon quantum dots as “Semiconductor electrolytes”: Optimization between H2O2 and solar electricity production}, volume = {12}, year = {2025}, }
• (2025). Semaphorin 3E-plexin-d1 pathway downstream of the luteinizing hormone surge regulates ovulation, granulosa cell luteinization, and ovarian angiogenesis in mice. ADVS, 12(29), e17163. (www)

  @article{ , abstract = {Ovulation is induced by the luteinizing hormone (LH) surge and accompanied by granulosa cell luteinization and ovarian angiogenesis. Semaphorin 3E (Sema3E)-Plexin-D1 pathway regulates angiogenesis in other tissues, but its role in the ovary is unknown. Evidence indicates that Sema3E-Plexin-D1 pathway plays an important role in the mouse ovary. The expression of Sema3E and its receptor, Plexin-D1, is dynamically regulated in the mouse ovary downstream of the LH surge. This regulation requires the modulation of chromatin accessibility by CCAAT/enhancer-binding proteins α and β. Intraovarian injection of recombinant Sema3E results in reduced ovulation, impaired corpus luteum formation, and aberrant ovarian angiogenesis. These in vivo physiological abnormalities are consistent with altered expression of genes regulating these processes, and with data from in vitro cultured granulosa cells and ovarian stromal tissues treated with Sema3E or neutralizing antibody of Plexin-D1. The findings pinpoint Sema3E-Plexin-D1 pathway as a potential therapeutic target for fertility and infertility management.}, archive = {J_ADVS}, author = {Hanxue Zhang and Jimmy Dhillon and Paul D. Soloway and Bo Shui and Seoyeon Lee and Jennifer K. Grenier and Paul R. Munn and M. Cecilia Ljungberg and Rebecca B Williams and Rainer B. Lanz and Yu-Hsiang Liao and Yi A. Ren}, doi = {10.1002/advs.202417163}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e17163}, shortjournal = {Adv. Sci.}, title = {Semaphorin 3E-plexin-d1 pathway downstream of the luteinizing hormone surge regulates ovulation, granulosa cell luteinization, and ovarian angiogenesis in mice}, volume = {12}, year = {2025}, }
• (2025). Pyruvate carboxylase in macrophages aggravates atherosclerosis by regulating metabolism reprogramming to promote inflammatory responses through the hypoxia-inducible factor-1 signaling pathway. ADVS, 12(29), e17128. (www)

  @article{ , abstract = {Atherosclerosis (AS) is a major cause of cardiovascular diseases, driven by chronic inflammation and macrophage polarization toward a proinflammatory phenotype. Pyruvate carboxylase (PC), a mitochondrial enzyme involved in glucose metabolism, is implicated in various metabolic disorders; however, its role in AS remains unclear. This study aims to investigate the role and mechanism of PC on macrophages in AS. PC is upregulated in macrophages of humans and mice with AS. Myeloid cell-specific PC knockout mice are generated to investigate the effects of PC deletion on atherosclerotic plaque formation. Myeloid cell-specific PC deficiency mitigates high-fat diet-induced atherosclerotic lesions in apolipoprotein E knockout mice and mice injected with adeno-associated virus- PCSK9 DY . PC deletion enhances mitochondrial respiration and reduces glycolytic activity, thereby reducing reactive oxygen species overproduction and mitochondrial damage in macrophages. PC activates the hypoxia-inducible factor-1 (HIF-1) signaling pathway through macrophage metabolic reprogramming. PC induces nuclear translocation of HIF-1α in atherosclerotic aortic roots by preventing HIF-1α from proteasome degradation. HIF-1α stabilizer reverses the anti-inflammatory effect of macrophage-PC ablation in atherogenesis; however, inhibiting HIF-1α suppresses the proinflammatory macrophage phenotype induced by PC overexpression. This study indicates that macrophage PC aggravates AS through macrophage metabolic reprogramming, promoting inflammatory responses in macrophages through the HIF-1 signaling pathway.}, archive = {J_ADVS}, author = {Ling-Na Zhao and Rui-Ling Wang and Ran-Xin Liu and Meng-Ru Zheng and Li Zhao and Bao-Feng Li and Jia-Le Li and De-Shen Liu and Xiao-Xia He and Qin-Bao Peng and Kai Li and Tian-Xiao Lin and Ying-Ying Liu and Sheng-Ping He and Jun Lu and Shao-Yi Zheng and Xiu Liu and Fang-Ze Huang}, doi = {10.1002/advs.202417128}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e17128}, shortjournal = {Adv. Sci.}, title = {Pyruvate carboxylase in macrophages aggravates atherosclerosis by regulating metabolism reprogramming to promote inflammatory responses through the hypoxia-inducible factor-1 signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Small RNA toxin-assisted evolution of GC-preferred ErCas12a for enhanced genome targeting range. ADVS, 12(29), e17105. (www)

  @article{ , abstract = {CRISPR/Cas12a, a promising gene editing technology, faces limitations due to its requirement for a thymine (T)-rich protospacer adjacent motif (PAM). Despite the development of Cas12a variants with expanded PAM profiles, many genomic loci, especially those with guanine-cytosine (GC)-rich PAMs, have remained inaccessible. This study develops a small RNA toxin-aided strategy to evolve ErCas12a for targeting GC-rich PAMs, resulting in the creation of enhanced ErCas12a (enErCas12a). EnErCas12a demonstrates the ability to recognize GC-rich PAMs and target five times more PAM sequences than the wild-type ErCas12a. Furthermore, enErCas12a achieves efficient gene editing in both bacterial and mammalian cells at various sites with non-canonical PAMs, including GC-rich PAMs such as GCCC, CGCC, and GGCC, which are inaccessible to previous Cas12a variants. Moreover, enErCas12a effectively targets PAM sequences with a GC content exceeding 75% in mammalian cells, providing a valuable alternative to the existing Cas12a toolkit. Importantly, enErCas12a maintains high specificity at targets with canonical PAMs, while also demonstrating enhanced specificity at targets with non-canonical PAMs. Collectively, this work establishes enErCas12a as a promising tool for gene editing in both eukaryotes and prokaryotes.}, archive = {J_ADVS}, author = {Zehua Chen and Junyuan Xue and Ziying Wang and Jinyuan Sun and Yinglu Cui and Tong Zhu and Huaiyi Yang and Ming Li and Bian Wu}, doi = {10.1002/advs.202417105}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e17105}, shortjournal = {Adv. Sci.}, title = {Small RNA toxin-assisted evolution of GC-preferred ErCas12a for enhanced genome targeting range}, volume = {12}, year = {2025}, }
• (2025). Versatile and robust reservoir computing with PWM-driven heterogenous R–C circuits. ADVS, 12(29), e16413. (www)

  @article{ , abstract = {Physical reservoir computing (PRC) holds great promise for low-latency, energy-efficient information processing, yet current implementations often suffer from limited flexibility, adaptability, and environmental stability. Here, a PRC system based on pulse-width modulation (PWM)-encoded resistor-capacitor ( R – C ) circuits is introduced, achieving exceptional versatility and robustness. By leveraging customizable nonlinearities and dynamic timescales, this system achieves state-of-the-art performance across diverse tasks, including chaotic time-series forecasting (NRMSE = 0.015 for Mackey-Glass) and complex multiscale tasks (94% accuracy for multiclass heartbeat classification). Notably, the design reduces relative errors by 98.4% across different device batches and under temperature variations compared to memristor-based reservoirs. These features position the approach as a scalable, adaptive, and energy-efficient solution for edge computing in dynamic environments, paving the way for robust and practical analog computing systems.}, archive = {J_ADVS}, author = {Zelin Ma and Huasen Yi and Ziping Zheng and Zhanyi Chen and Weicheng Liu and Yibing Chen and Bojun Cheng and Chang Cai and Shusheng Pan and Jun Ge}, doi = {10.1002/advs.202416413}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e16413}, shortjournal = {Adv. Sci.}, title = {Versatile and robust reservoir computing with PWM-driven heterogenous R–C circuits}, volume = {12}, year = {2025}, }
• (2025). Biosecurity primitive: Polymerase X-based genetic physical unclonable functions. ADVS, 12(29), e15820. (www)

  @article{ , abstract = {A Physical Unclonable Function (PUF) is a security primitive that exploits inherent variations in manufacturing protocols to generate unique, random-like identifiers. These identifiers are used for authentication and encryption purposes in hardware security applications in the semiconductor industry. Inspired by the success of silicon PUFs, herein it is leverage Terminal deoxynucleotidyl Transferase (TdT), a template-independent polymerase belonging to the X-family of DNA polymerases, to augment the intrinsic entropy generated during DNA lesion repair and rapidly produce genetic PUFs that satisfy the following properties: robustness (i.e., they repeatedly produce the same output), uniqueness (i.e., they do not coincide with any other identically produced PUF), and unclonability (i.e., they are virtually impossible to replicate). Furthermore, a post-sequencing feature selection methodology based on logistic regression to facilitate PUF classification is developed. This experimental and computational pipeline drastically reduces production time and cost compared to conventional genetic barcoding without compromising the stringent PUF criteria of uniqueness and unclonability. This results provide novel insights into the function of TdT and represent a major step toward utilization of PUFs as a biosecurity primitive for cell line authentication and provenance attestation.}, archive = {J_ADVS}, author = {Zikun Zhou and Taek Kang and Jie Chen and Yesh Doctor and Jocelyn G Camposagrado and Yiorgos Makris and Alexander Pertsemlidis and Leonidas Bleris}, doi = {10.1002/advs.202415820}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e15820}, shortjournal = {Adv. Sci.}, title = {Biosecurity primitive: Polymerase X-based genetic physical unclonable functions}, volume = {12}, year = {2025}, }
• (2025). Apoptotic bodies restore NAD and mitochondrial homeostasis in fibroblasts. ADVS, 12(29), e15691. (www)

  @article{ , abstract = {Fibrotic skin diseases are characterized by excessive fibroblast proliferation and pathological extracellular matrix deposition. As a pivotal coenzyme in cellular energetics, NAD homeostasis perturbation is implicated in fibrosis. Multiple studies have demonstrated the therapeutic potential of mesenchymal stem cells (MSCs) against cutaneous fibrosis, while the specific mechanism remains elusive. Herein, this work finds that although almost all MSCs undergo in situ apoptosis within 24 h post-subcutaneous administration, MSC-derived apoptotic bodies (ABs) mediated potent anti-fibrotic effects. Mechanistically, ABs can restore NAD and mitochondrial homeostasis through NAMPT transfer, FOXO1 deacetylation enhancement, and PINK1/PARKIN-dependent mitophagy activation. To achieve penetration into the hard matrix of fibrotic skin, permeable apoptotic bodies (pABs) are constructed via metabolic glycoengineering and copper-free click chemistry techniques. In both keloid xenograft and scleroderma murine models, pABs can significantly penetrate collagen matrix and reduce skin fibrosis. In summary, this research establishes a highly promising strategy for reversing skin fibrosis with hard fibrotic matrix.}, archive = {J_ADVS}, author = {Shutong Qian and Siya Dai and Chunyi Guo and Wenjun Wang and Jiajia Pang and Yichen Shen and Mingyuan Xu and Jie Hu and Wenguo Cui and Xiaoming Sun and Jinghong Xu}, doi = {10.1002/advs.202415691}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e15691}, shortjournal = {Adv. Sci.}, title = {Apoptotic bodies restore NAD and mitochondrial homeostasis in fibroblasts}, volume = {12}, year = {2025}, }
• (2025). Mesenchymal stromal cell secretome and its key bioactive metabolites induce long-term neuroprotection after traumatic brain injury in mice. ADVS, 12(29), e15508. (www)

  @article{ , abstract = {The severe and long-term consequences of traumatic brain injury (TBI) highlight the urgent need for effective neuroprotective therapies. Mesenchymal stromal cells (MSCs) show promise in TBI treatment through their secretome (conditioned media, CM). A low-molecular-weight (<700 Da) CM fraction with neuroprotective effects comparable to total CM after acute brain injury in vitro is previously identified. Here, it is aimed at identifying key bioactive factors, reconstituting them into a synthetic cocktail (SYNT), and evaluating its efficacy in TBI models. Metabolomic profiling identified three prostaglandins and kynurenine, which are used to create SYNT. The SYNT formulation reduced cell death, neuronal damage, and induced protective gene expression changes associated with neuronal protection and microglia modulation toward beneficial phenotype after TBI in vitro. In vivo, SYNT conferred similar long-term functional benefits as CM, improving sensorimotor function up to 6 months and memory preservation at 4 months compared to saline-treated animals, though only CM reduced contusion volume at 5 months. Both treatments modulated neuroinflammation, evidenced by reduced microglial activation and astrogliosis in the pericontusional tissue at 6 months. These findings demonstrate the neuroprotective effects of MSC-secretome treatment in TBI and highlight prostaglandins and kynurenine as key mediators of this response. The findings lay the groundwork for developing a standardized, cell-free therapeutic strategy for TBI based on MSC derivatives.}, archive = {J_ADVS}, author = {Francesca Pischiutta and Francesca Tribuzio and Marta Magatti and Giulia De Simone and Federico Moro and Giovanni Nattino and Fabiola Signorini and Luther Loose and Enrico Caruso and Costanza Bertani and Edoardo Mazzone and Rosaria Pascente and Edoardo Micotti and Antonietta Rosa Silini and Fabrizio Ortolano and Maria Chiara Trolese and Marco Bolis and Luca Guarrera and Martina Bruna Violatto and Paolo Bigini and Cristina Banfi and Roberta Pastorelli and Ornella Parolini and Laura Brunelli and Elisa R Zanier}, doi = {10.1002/advs.202415508}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e15508}, shortjournal = {Adv. Sci.}, title = {Mesenchymal stromal cell secretome and its key bioactive metabolites induce long-term neuroprotection after traumatic brain injury in mice}, volume = {12}, year = {2025}, }
• (2025). Activation of HTR2B suppresses osteosarcoma progression through the STAT1-NLRP3 inflammasome pathway and promotes OASL1+ macrophage production to enhance antitumor immunity. ADVS, 12(29), e15276. (www)

  @article{ , abstract = {Osteosarcoma is a primary malignant bone tumor originating from mesenchymal tissue, and associated with poor prognosis. The 5-hydroxytryptamine receptor 2B (HTR2B), a receptor for serotonin, is known to play a role in the progression of multiple tumors. This study aims to explore the potential roles of HTR2B in osteosarcoma progression. HTR2B expression is analyzed using the TARGET, GEO databases, and osteosarcoma tissue samples in the hospital. Lentivirus and agonist BW-723C86 are employed to assess HTR2B overexpression effects in osteosarcoma cell lines. Transcriptome sequencing analysis and single-cell sequencing are performed to identify potential downstream molecules and signaling pathways, and the changes in tumor immune microenvironment. The investigation demonstrates that HTR2B is downregulated in osteosarcoma tissues, and correlates with poorer survival outcomes. Upregulating HTR2B through lentiviral-mediated gene delivery or the agonist BW-723C86, resulted in a marked suppression of osteosarcoma cell progression via the STAT1-NLRP3 inflammasome pathway. Single-cell sequencing of CD45+ cells reveals that HTR2B activation enhances the production of OASL1+ macrophages, contributing to the observed enhancement of antitumor immunity. These findings propose HTR2B as a novel therapeutic target for treating osteosarcoma, offering a dual mechanism of action that directly impedes tumor cell proliferation and augments the host immune response.}, archive = {J_ADVS}, author = {Zhen Huang and Jiazhuang Zhu and Jianping Hu and Xingkai Wang and Xiaolong Ma and Enjie Xu and Kunpeng Zhu and Chunlin Zhang}, doi = {10.1002/advs.202415276}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e15276}, shortjournal = {Adv. Sci.}, title = {Activation of HTR2B suppresses osteosarcoma progression through the STAT1-NLRP3 inflammasome pathway and promotes OASL1+ macrophage production to enhance antitumor immunity}, volume = {12}, year = {2025}, }
• (2025). The non-canonical ChREBPα activity suppresses the activation of hepatic stellate cells and liver fibrosis by antagonizing TGF-β-E2F1 axis. ADVS, 12(29), e15032. (www)

  @article{ , abstract = {Sustained activation of hepatic stellate cells (HSCs) drives liver fibrosis in response to chronic liver injury and inflammation. It is reported that profibrogenic signals released from stressed/injured hepatocytes evoke fibrogenic responses in HSCs. However, intrahepatocyte players that modulate such cell-to-cell communications remain poorly defined. In this study, hepatic ChREBPα is found to be reduced in mouse models of chemical-induced liver fibrosis as well as in three groups of human patients with liver fibrosis. Chrebpα-LKO mice are highly sensitive to both chemical (CCL4 and TAA) and bile duct ligation (BDL)-induced liver injury and developed more advanced liver fibrosis without affecting liver lipid content. Hepatocyte ChREBPα overexpression suppressed the activation of HSCs in an in vitro medium transfer experiment in part via inhibiting the expression of profibrogenic factors THBS1 and CTGF. RNA-Seq analysis revealed that E2F1, a novel effector of TGFβ-mediated fibrogenic pathway, is highly induced in the liver of Chrebpα-LKO mice. Hepatic knockdown of E2F1 ameliorated the increased liver fibrosis in mice with hepatic Chrebpα deficiency while reducing the expression of hepatic THBS1 and CTGF.}, archive = {J_ADVS}, author = {Jian Zhang and Yuee Zhao and Gauthami Pulivendala and Qing Zhang and Liangyou Rui and Jiashi Gao and Huiwen Wang and Gary Zhang and Alli Nuotio-Antar and Xin Tong and Lei Yin}, doi = {10.1002/advs.202415032}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e15032}, shortjournal = {Adv. Sci.}, title = {The non-canonical ChREBPα activity suppresses the activation of hepatic stellate cells and liver fibrosis by antagonizing TGF-β-E2F1 axis}, volume = {12}, year = {2025}, }
• (2025). Correction to “Disruption of super-enhancers in activated pancreatic stellate cells facilitates chemotherapy and immunotherapy in pancreatic cancer”. ADVS, 12(29), e07548. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202507548}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e07548}, shortjournal = {Adv. Sci.}, title = {Correction to “Disruption of super-enhancers in activated pancreatic stellate cells facilitates chemotherapy and immunotherapy in pancreatic cancer”}, volume = {12}, year = {2025}, }
• (2025). Mitochondria-targeted ROS scavenging natural enzyme cascade nanogels for periodontitis treatment via hypoxia alleviation and immunomodulation. ADVS, 12(29), e07481. (www)

  @article{ , abstract = {Periodontitis is a chronic inflammatory disease characterized by hypoxia, excessive oxidative stress, and immune dysregulation, leading to tissue destruction and bone resorption. Although antioxidants can reduce ROS and inflammation, most lack specificity and have a short residence time, limiting their effectiveness. Since mitochondria are the primary source of ROS, targeting mitochondrial ROS is a promising strategy for periodontitis treatment. However, this alone cannot address the complex “ROS-inflammation-hypoxia” cycle in periodontitis, requiring a more comprehensive approach. Here, a natural enzyme cascade nanogel (TPP-SAT) composed of triphenylphosphine (TPP), superoxide dismutase (SOD), and catalase (CAT) via in-situ polymerization is developed. TPP-SAT targets mitochondrial ROS, converting ROS (such as H 2 O 2 or ·O 2 − ) into O 2 through the enzyme cascade of SOD and CAT. This alleviates hypoxia, prevents oxidative damage, and restores the balance between pro-inflammatory M1 and anti-inflammatory M2 macrophages, reducing inflammation and immune dysfunction. TPP-SAT breaks the “ROS-inflammation-hypoxia” cycle, inhibits alveolar bone resorption, and accelerates periodontal tissue regeneration. This approach offers a promising strategy for treating periodontitis and other chronic inflammatory diseases, with strong clinical potential.}, archive = {J_ADVS}, author = {Yanfen Zheng and Liuzhou Mao and Qi Wang and Haohua Hu and Bahriman Xarpidin and Zheng Luo and Yun-Long Wu}, doi = {10.1002/advs.202507481}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e07481}, shortjournal = {Adv. Sci.}, title = {Mitochondria-targeted ROS scavenging natural enzyme cascade nanogels for periodontitis treatment via hypoxia alleviation and immunomodulation}, volume = {12}, year = {2025}, }
• (2025). Correction to “[Integration of circulating tumor DNA and metabolic parameters on 18F-fludeoxyglucose positron emission tomography for outcome prediction in unresectable locally advanced non-small cell lung cancer]”. ADVS, 12(29), e06627. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202506627}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e06627}, shortjournal = {Adv. Sci.}, title = {Correction to “[Integration of circulating tumor DNA and metabolic parameters on 18F-fludeoxyglucose positron emission tomography for outcome prediction in unresectable locally advanced non-small cell lung cancer]”}, volume = {12}, year = {2025}, }
• (2025). From seeds to cell: Improving PEMFC performance and durability by seed-mediation synthesis for PtNiIr ORR nanocatalysts. ADVS, 12(29), e05958. (www)

  @article{ , abstract = {Proton exchange membrane fuel cells (PEMFCs) provide efficient, green power solutions. However, the sluggish kinetics of the oxygen reduction reaction (ORR) at the cathode, with its need for elevated Pt loadings, lowers efficiency and raises cost, which hinders their wider implementation. Pt-based designer alloy electrocatalysts, more specifically ternary PtNiX nanocatalysts, hold great potential for improving ORR activity and thus overall cell performance. This study explores synthesis and performance evaluations of novel ternary PtNiIr ORR catalysts prepared using seed-mediation at different catalyst loadings and deposited on various carbon support materials. Membrane electrode assembly (MEA) performance evaluations are carried out to assess catalyst activity and stability under operating conditions, revealing better performance and durability for seed-mediated catalysts compared to the non-seed-mediated catalyst used as a reference. The results showed further improved performance and durability of the seed-mediated catalysts on porous carbon than solid carbon, due to the deposition of catalyst nanoparticles inside the carbon pores. Degradation analysis using online inductively coupled plasma – mass spectrometry (ICP-MS) indicated the dissolution of metals during contact with the electrolyte and under operating conditions, confirming the observed catalyst stability trends in MEA. The experiments highlighted the impact of catalyst composition and supports on the stability of the materials.}, archive = {J_ADVS}, author = {Lujin Pan and Thomas Merzdorf and Carlos A. Campos-Roldàn and An Guo and Jiasheng Lu and Johannes Schmidt and Marc Heggen and Malte Klingenhof and Xingli Wang and Sebastian Möhle and Sören Selve and Deborah Jones and Peter Strasser}, doi = {10.1002/advs.202505958}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e05958}, shortjournal = {Adv. Sci.}, title = {From seeds to cell: Improving PEMFC performance and durability by seed-mediation synthesis for PtNiIr ORR nanocatalysts}, volume = {12}, year = {2025}, }
• (2025). Mitigating cell cycle effects in multi-omics data: Solutions and analytical frameworks. ADVS, 12(29), e05823. (www)

  @article{ , abstract = {Cell cycle structures vary significantly across cell types, which exhibit distinct phase compositions. Asynchronous DNA replication and dynamic cellular characteristics during the cell cycle result in considerable heterogeneity in DNA dosage, chromatin accessibility, methylation, and expression. Nonetheless, the consequences of cell cycle disruption in the interpretation of multi-omics data remain unclear. Here, we systematically assessed the influence of distinct cell phase structures on the interpretation of omics features in proliferating cells, and proposed solutions for each omics dataset. For copy number variation (CNV) calling, asynchronous replication timing (RT) interference induces false CNVs in cells with high S-phase ratio (SPR), which are significantly decreased following replication timing domain (RTD) correction. Similar noise is observed in the chromatin accessibility data. Moreover, for DNA methylation and transcriptomic analyses, cell cycle-sorted data outperformed direct comparison in elucidating the biological features of compared cells. Additionally, we established an integrated pipeline to identify differentially expressed genes (DEGs) after cell cycle phasing. Consequently, our study demonstrated extensive cell-cycle heterogeneity, warranting consideration in future studies involving cells with diverse cell-cycle structures. RTD correction or phase-specific comparison could reduce the influence of cell cycle composition on the analysis of the differences observed between stem and differentiated cells.}, archive = {J_ADVS}, author = {Rui Nie and Caihong Zheng and Likun Ren and Yue Teng and Yaoyu Sun and Lifei Wang and Junya Li and Jun Cai}, doi = {10.1002/advs.202505823}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e05823}, shortjournal = {Adv. Sci.}, title = {Mitigating cell cycle effects in multi-omics data: Solutions and analytical frameworks}, volume = {12}, year = {2025}, }
• (2025). UTX responds to nanotopography to suppress macrophage inflammatory response by remodeling H3K27me3 modification. ADVS, 12(29), e05723. (www)

  @article{ , abstract = {Peri-implantitis is the leading cause of implant failure, primarily due to weak defense at the implant–soft tissue interface, which disrupts the local immune microenvironment. As an integral part of this microenvironment, the implant–tissue interface plays a critical role in shaping immune cell function. Thus, engineering the surface topography of implants has emerged as a novel strategy for sustained immunomodulation following implantation. This study investigated the mechanical regulation of macrophage function by nanopatterned topographies. Titanium nanotubes (TNTs) surfaces reduce the expression of phosphorylated myosin light chain (pMLC) and promote the retention of the UTX histone methyltransferase in the nucleus. This process attenuates the enrichment of the repressive H3K27me3 histone marker at the Abca1 gene locus, increasing Abca1 expression and suppressing inflammation. This study reveals the mechanosensitivity of UTX and provides a new target for the development of therapeutic strategies that integrate mechanical signaling and immune modulation.}, archive = {J_ADVS}, author = {Hengji Jia and He Zhang and Dingqiang Mo and Bo Xie and Hongdou Qiao and Tao Chen and Haoyue Song and Xinxin Xu and Sheng Yang}, doi = {10.1002/advs.202505723}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e05723}, shortjournal = {Adv. Sci.}, title = {UTX responds to nanotopography to suppress macrophage inflammatory response by remodeling H3K27me3 modification}, volume = {12}, year = {2025}, }
• (2025). Pyroptosis-inducing Platinum(IV) prodrugs via GSDME pathway for chemoimmunotherapy and metastasis inhibition in triple-negative breast cancer. ADVS, 12(29), e05567. (www)

  @article{ , abstract = {Pyroptosis has attracted significant attention for its role in cancer chemotherapy and immunotherapy. However, few drugs have been reported to induce pyroptosis via the Caspase-3/gasdermin E (GSDME) pathway. Herein, three novel Pt IV prodrugs, MRP , DRP , and HRP are rationally designed by conjugating DNA methyltransferase (DNMT) inhibitor (RG108) and/or histone deacetylase (HDAC) inhibitor (PhB) to the Pt IV center. These prodrugs can be easily reduced to cisplatin ( CDDP ) due to the high glutathione (GSH) levels in tumors, liberating the coordinated ligands. Released RG108 reactivates the GSDME gene and reduces pyroptosis in low GSDME-expressing tumor cells. Meanwhile, PhB-induced chromatin loosening enhances CDDP-DNA binding, which not only increases Caspase-3 expression, but also upregulates GSDME. HRP demonstrates superior ability to suppress tumor growth and metastasis while reducing systemic toxicity compared with CDDP . By reactivating GSDME and loosening chromatin, HRP effectively boosts tumor cell pyroptosis and exhibits the most pronounced anticancer performance. These findings highlight HRP ’s potential as a therapeutic agent for triple-negative breast cancer (TNBC) and offer innovative strategies for combining chemotherapy with immunotherapy. To the best of current knowledge, this is the first report of platinum complexes inducing pyroptosis via the Caspase-3/GSDME pathway in low GSDME-expressing tumor cells.}, archive = {J_ADVS}, author = {Xinda Yang and Chuansheng Xu and Youliang Zeng and Chunhui Wang and Yan Gao and Jie Ding and Sirui Chen and Yuheng Pan and Xin Zhang and Zongwan Mao and Shuo Shi}, doi = {10.1002/advs.202505567}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e05567}, shortjournal = {Adv. Sci.}, title = {Pyroptosis-inducing Platinum(IV) prodrugs via GSDME pathway for chemoimmunotherapy and metastasis inhibition in triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). A pH-sensitive nanosized Covalent–Organic polymer for enhanced tumor photodynamic immunotherapy by hypoxia relief and STAT3 inhibition. ADVS, 12(29), e04860. (www)

  @article{ , abstract = {Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen species (ROS) and triggering immunogenic cell death. However, the therapeutic effect of PDT is strongly limited by tumor hypoxia and immunosuppressive landscape. Herein, a pH-sensitive nanosized covalent–organic polymer (COP), composed of the photosensitizer porphyrin and pyruvate kinase inhibitor vitamin K3 (VK3), is designed to overcome these issues. The signal transducer and activator of transcription 3 (STAT3) inhibitor WP1066 is further encapsulated into COPs to form a WP1066-loaded COP (TVW). As an inhibitor of pyruvate kinase, VK3 can reduce intracellular oxygen consumption by inhibiting the glycolytic pathway, leading to the alleviation of the tumor hypoxic microenvironment. The relief of tumor hypoxia by VK3 enhances photodynamic cytotoxicity by generating more ROS. Meanwhile, STAT3 acts as a major regulator of PD-L1, a key inhibitor that promotes immune escape. WP1066 effectively inhibits the expression of STAT3 and reduces PD-L1 expression, thereby significantly inhibiting tumor immune escape and enhancing antitumor efficacy in a synergistic manner. The antitumor capacity of photodynamic immunotherapy is extensively investigated in a murine subcutaneous hepatocellular carcinoma model. This photo-immunotherapy may provide an effective combination regimen for the efficient treatment of solid tumors such as hepatocellular carcinoma.}, archive = {J_ADVS}, author = {Lei Lei and Wenbin Dai and Jinchao Zhao and Angfeng Jiang and Haisheng Peng and Qiao Jin and Xiaojing Li and Zhe Tang}, doi = {10.1002/advs.202504860}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e04860}, shortjournal = {Adv. Sci.}, title = {A pH-sensitive nanosized Covalent–Organic polymer for enhanced tumor photodynamic immunotherapy by hypoxia relief and STAT3 inhibition}, volume = {12}, year = {2025}, }
• (2025). Visualization of the spiral ganglion neuron in vivo using a novel 177Lu nuclear molecule label. ADVS, 12(29), e04464. (www)

  @article{ , abstract = {For patients with severe and profound hearing loss, cochlear implant (CI), a common and effective modality for restoring hearing, directly stimulates spiral ganglion neurons (SGNs) to generate electrical activity and form auditory perception. However, the postoperative outcome of CI is significantly influenced by the number of surviving SGNs, ​​which is a key focus of preoperative evaluation​​. Existing audiologic function and radiographic tests cannot directly demonstrate the integrity of inner ear primary neurons. In this study, ​​we developed and validated​​ a radionuclide-labeled anti-vesicular glutamate transporter 1 (anti-VGLUT1) antibody-drug and achieved animal-level in vivo imaging of cochlear SGNs using nuclear imaging. By screening the public single-cell sequencing database, it is found that VGLUT1 can serve as a representative cell membrane marker for SGN in the cochlea. The potential of anti-VGLUT1 conjugated to the long half-life 177 Lu as a molecular probe to detect the relative number of SGNs in SGN-injured mouse and pig models is explored. The study provides a novel method for assessing cochlear nerve integrity in vivo by visualizing target antigen expression levels through nuclear imaging. This approach is promising to help CI candidates with preoperative inner ear SGN integrity assessment, contributing to clinical decision-making.}, archive = {J_ADVS}, author = {Chenyang Kong and Xiaohui Wang and Jintao Yu and Li Wen and Chengwen Zheng and Ge Yin and Kai Xu and Weiwei He and Hao Wang and Xiaoli Lan and Dawei Jiang and Yu Sun}, doi = {10.1002/advs.202504464}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e04464}, shortjournal = {Adv. Sci.}, title = {Visualization of the spiral ganglion neuron in vivo using a novel 177Lu nuclear molecule label}, volume = {12}, year = {2025}, }
• (2025). Ezetimibe engineered l14-8 suppresses advanced prostate cancer by activating PLK1/TP53-SAT1-induced ferroptosis. ADVS, 12(29), e04192. (www)

  @article{ , abstract = {Androgen receptor signaling inhibitors (ARSIs) have demonstrated a survival benefit in metastatic prostate cancer. However, patients taking these agents inevitably acquire resistance and even develop neuroendocrine prostate cancer (NEPC), in which stage the AR signaling is inactive, and therapies are limited for these lethal cases. Therefore, developing novel treatments independent of the AR signaling pathway is urgently needed. Here it is reported that L14-8, a small molecule is derived and optimized from ezetimibe, a marketed drug primarily used for intestinal cholesterol and phytosterol absorption, significantly suppresses cell growth in advanced prostate cancer by inducing ferroptosis. Mechanistically, L14-8 binds to and promotes the ubiquitin-mediated PLK1 degradation, resulting in an increase of downstream TP53 protein phosphorylation, which is further enriched at the promoter of SAT1 , a well-established ferroptosis inducer, and boosting SAT1 transcription thus triggers ferroptosis-mediated cancer cell death. Importantly, in vivo studies further demonstrate a potent anti-tumor efficacy of L14-8 without obvious toxicity. Overall, this study develops a novel small molecular engineered from ezetimibe for treating lethal prostate cancer in an AR-independent manner and provides mechanistic insights into its action by triggering PLK1-TP53- SAT1 axis-mediated ferroptosis in lethal PCa models independent of the AR signaling pathway.}, archive = {J_ADVS}, author = {Yu Zhang and Xiao-wen Song and Na Zhang and Xue-hui Li and Fan-chen Wu and Yu-ang Wei and Dong-liang Xu and Ling-fan Xu and Fu-wen Yuan}, doi = {10.1002/advs.202504192}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e04192}, shortjournal = {Adv. Sci.}, title = {Ezetimibe engineered l14-8 suppresses advanced prostate cancer by activating PLK1/TP53-SAT1-induced ferroptosis}, volume = {12}, year = {2025}, }
• (2025). Delayed transplantation of neural stem cells improves initial graft survival after stroke. ADVS, 12(29), e04154. (www)

  @article{ , abstract = {Neural stem cell therapies hold great promise for improving stroke recovery, but the hostile stroke microenvironment can hinder the initial graft survival. It has long been well documented that the microenvironment evolves over time, making it crucial to identify the optimal transplantation window to maximize therapeutic efficacy. However, it remains uncertain whether acute or delayed local cell transplantations better supports graft viability after stroke. Here, it is shown that delayed intracerebral transplantation of neural progenitor cells (NPCs) derived from human induced pluripotent cells (iPSCs) at 7 days post stroke significantly enhances graft proliferation and survival, and promotes axonal sprouting, compared to acute transplantation at 1 day post stroke, in a mouse model of large cortical stroke. Using in vivo bioluminescence imaging over a 6-week period post-transplantation, a more than fivefold increase is observed in bioluminescence signal in mice that received delayed NPC therapy, compared to those that underwent acute NPC transplantation. The increased number of cell grafts in mice receiving delayed NPC transplantation is driven by increased proliferation rates early after transplantation, which subsequently declines to similarly low levels in both groups. Notably, it is found that the majority of transplanted NPCs differentiate into neurons after 6 weeks, with no significant differences in the neuron-to-glia ratio between acute and delayed transplantation groups. These findings suggest that delayed NPC transplantation improves early graft survival and proliferation, which could help identify the optimal therapeutic window for maximizing the effectiveness of NPC-based therapies in stroke.}, archive = {J_ADVS}, author = {Rebecca Z Weber and Nora H Rentsch and Beatriz Achón Buil and Melanie Generali and Lina R. Nih and Christian Tackenberg and Ruslan Rust}, doi = {10.1002/advs.202504154}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e04154}, shortjournal = {Adv. Sci.}, title = {Delayed transplantation of neural stem cells improves initial graft survival after stroke}, volume = {12}, year = {2025}, }
• (2025). B-site-metal-mediated coke-resistant CO2 electrolysis on perovskite surfaces. ADVS, 12(29), e03970. (www)

  @article{ , abstract = {High-temperature CO 2 reduction to CO using perovskite-oxide-based solid oxide electrochemical cells holds promise for carbon-neutral chemical production, yet currently faces the challenge of coke formation that leads to device failure. A key reason behind this challenge is the absence of a correlation between the coke formation mechanism and perovskite structures. Here, lanthanum strontium cobalt ferrite perovskites are taken with a classical ABO 3 structure as examples to study coke formation on them and unravel the dependence of coke resistance on the Fe stoichiometry. Lowering the Co versus Fe ratio suppresses B-site metal exsolution, and thus, coke formation is catalyzed by these metals/alloys. Using (La 0.6 Sr 0.4 ) 0.95 Co 0.2 Fe 0.8 O 3-δ as an example, this study reports an outlet CO pressure of 0.86 ± 0.02 atm at 800 °C, closely approaching the thermodynamic threshold for coking. The cell offers a stable outlet CO pressure of ≈0.8 atm in 320-h electrolysis at 220 mA cm −2 and the potential to build a high-performance tandem system for efficient electrosynthesis of multi-carbon products from CO 2 .}, archive = {J_ADVS}, author = {Tongbao Wang and Yu Mao and Pengfei Ou and Zhijie Wang and Yifan Li and Hao Li and Binbin Pan and Ximeng Lv and Yanguang Li and Gengfeng Zheng and Chengzhi Guan and Yi Cui and Ziyun Wang and Yuhang Wang}, doi = {10.1002/advs.202503970}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e03970}, shortjournal = {Adv. Sci.}, title = {B-site-metal-mediated coke-resistant CO2 electrolysis on perovskite surfaces}, volume = {12}, year = {2025}, }
• (2025). DNA origami-based CD44-targeted therapy silences stat3 enhances cartilage regeneration and alleviates osteoarthritis progression. ADVS, 12(29), e03939. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a widespread musculoskeletal disorder affecting ≈600 million people globally, and small interfering RNA (siRNA) therapy shows potential in targeting OA progression. However, the efficient and targeted delivery of siRNA remains a major challenge due to issues with tissue specificity and degradation in vivo. In this study, A DNA origami-based chondrocyte-targeted delivery system (OCS) is designed for siRNA delivery to OA-affected cartilage. The DNA origami is engineered to load with siRNA targeting signal transducer and activator of transcription 3 (Stat3), a key regulator of inflammation and cartilage degradation, and is functionalized with anti-CD44 aptamers for selective targeting of OA chondrocytes. In vitro, the DNA origami system effectively delivers siRNA to diseased chondrocytes, silencing matrix metalloproteinases expression and reducing inflammation. In OA rat models, it preserves cartilage integrity, promotes regeneration, and mitigates ECM degradation without evident side effects. These findings highlight DNA origami as a promising platform for siRNA-based OA therapy, offering a promising solution to the challenges of targeted and efficient siRNA delivery.}, archive = {J_ADVS}, author = {Qi Lv and Xiang Zhao and Songsong Teng and Xinmeng Jin and Ying Zhou and Yueyang Sun and Hao Pei and Zuoqin Yan and Chunhui Ma}, doi = {10.1002/advs.202503939}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e03939}, shortjournal = {Adv. Sci.}, title = {DNA origami-based CD44-targeted therapy silences stat3 enhances cartilage regeneration and alleviates osteoarthritis progression}, volume = {12}, year = {2025}, }
• (2025). Advanced atomic layer modulation based highly homogeneous PtRu precious metals alloy thin films. ADVS, 12(29), e03561. (www)

  @article{ , abstract = {Atomic layer modulation (ALM) presents a novel approach for controlling the stoichiometry of platinum-ruthenium (PtRu) alloys rather than a tedious atomic layer deposition (ALD) supercycling multielement ALD process. This method sequentially pulses dimethyl-( N,N -dimethyl-3-butene-1-amine- N )platinum (C 8 H 19 NPt, DDAP) and tricarbonyl(trimethylenemethane)ruthenium [Ru(TMM)(CO) 3 ] precursors with O 2 as a counter reactant at 225 °C to produce ALM-PtRu bimetallic alloys at the nanoscale. By smartly adjusting precursor pulsing times and temperatures, the average surface composition during growth can be modulated, achieving precise control over the PtRu alloy stoichiometry. Aberration-corrected ultra-high-resolution scanning transmission electron microscope, Rutherford backscattered spectrometry, and advanced X-ray diffraction analytical tools demonstrate homogenized Pt and Ru elemental distribution without localized segregation with adjustable Pt:Ru ratios ranging from 28:72 to 97:3. Demonstrating ≈100% step coverage on the high aspect ratio (≈30) 3D trench structures (top width of 125 nm, bottom width of 85 nm), the alloy maintains uniform thickness (≈30 nm) throughout its layers. ALM-PtRu demonstrates durable and superior electrocatalytic performance compared to benchmark precious metal catalysts like ALD-Pt and ALD-Ru. This study highlights ALM's potential for precise alloy stoichiometry in PtRu films, offering significant promise for various applications, particularly electrocatalysis, and extending ALM to other metallic alloy systems.}, archive = {J_ADVS}, author = {Yeseul Son and Sang Bok Kim and Debananda Mohapatra and Taehoon Cheon and Soo-Hyun Kim}, doi = {10.1002/advs.202503561}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e03561}, shortjournal = {Adv. Sci.}, title = {Advanced atomic layer modulation based highly homogeneous PtRu precious metals alloy thin films}, volume = {12}, year = {2025}, }
• (2025). Starch acetate grafted to MXene composite surpasses room temperature liquid electrolyte performance for all-solid-state lithium-ion batteries. ADVS, 12(29), e03285. (www)

  @article{ , abstract = {A groundbreaking solid polymer electrolyte (SPE) design is reported that outperforms traditional liquid electrolytes in both performance and safety, while being environmentally benign. By leveraging click chemistry, starch acetate (SA) is integrated, a natural polymer itself capable of supporting superionic conductivity, with MXene quantum dots (MX-QDs). While the composite electrolyte is electrically insulating, the electrical conductivity of the MXene stabilizes the anionic species while also acting as a filler to boost mechanical properties. The optimized SPE composition, comprising 30 wt .% MX-QDs, exhibits exceptional electrochemical characteristics: ionic conductivity of 14.8 mS cm −1 , lithium cation transfer number of 0.91, and an electrochemical stability window of up to 5.2 V. Notably, this SPE demonstrates seamless compatibility with lithium metal anodes, enabling a solid-state battery that retains 90% capacity over 1000 charge–discharge cycles. This innovative SPE design paves the way for the widespread adoption of solid-state batteries in electric vehicles.}, archive = {J_ADVS}, author = {Saeed Hadad and Mahtab Hamrahjoo and Homayun Khezraqa and Marzieh Golshan and Zhaohui Wang and Mehdi Salami-Kalajahi}, doi = {10.1002/advs.202503285}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e03285}, shortjournal = {Adv. Sci.}, title = {Starch acetate grafted to MXene composite surpasses room temperature liquid electrolyte performance for all-solid-state lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). LIMK1 as a novel kinase of β-catenin promotes esophageal cancer metastasis by cooperating with CDK5. ADVS, 12(29), e03223. (www)

  @article{ , abstract = {Metastasis is a major cause of cancer deaths, but the underlying molecular mechanisms remain largely unknown. Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with poor survival, yet the key kinases driving ESCC metastasis and their biological function have not been fully discovered. Here, a kinase-substrate map of metastatic ESCC is presented for the first time by conducting a phosphoproteomics analysis of 60 clinical specimens. By further consolidating data with CRISPR/Cas9 functional screening, LIM domain kinase 1 (LIMK1) is identified as a novel kinase of β-catenin. The in vitro and in vivo experiments demonstrated that LIMK1 cooperates with Cyclin-dependent kinase 5 (CDK5) to promote cancer metastasis in a phosphorylation-dependent manner. Mechanistically, LIMK1 and CDK5 synergistically phosphorylate β-catenin at S191, enhancing its phosphorylation and interaction with Nucleoporin 93, resulting in β-catenin nuclear translocation and activation of key pathways in cancer metastasis. High expression of LIMK1 and CDK5 is associated with poor prognosis of ESCC patients, and the clinical and functional significance of LIMK1/CDK5-Wnt/β-catenin axis is also verified in esophageal adenocarcinoma, gastric cancer, and lung cancer. Furthermore, the combination of LIMK1 and CDK5 inhibitors significantly suppresses metastasis in multiple models. This work highlights LIMK1 as a novel regulatory and targetable kinase of β-catenin, informing the treatment of advanced cancer.}, archive = {J_ADVS}, author = {Shu-Jun Li and Zhuo-Ran Liang and Zhi-Chao Liu and Xue-Ping Luo and Jun-Yi Li and Xiao-Mei Yu and Xuan-Zhang Huang and Yan He and Tao-Yang Xu and Jiao-Jiao Xu and Shao-Cong Peng and Yu-Xiang Song and Xiao-Wan Zhuang and Can-Can Zheng and Fan Zhang and Alfred King-Yin Lam and Wei Dai and Ming-Liang He and Bo Liu and Qi Zhao and Guo-Liang Lu and Jin-Bao Liu and Zhen-Ning Wang and Zhi-Gang Li and Ze-Xian Liu and Wen-Wen Xu and Bin Li}, doi = {10.1002/advs.202503223}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e03223}, shortjournal = {Adv. Sci.}, title = {LIMK1 as a novel kinase of β-catenin promotes esophageal cancer metastasis by cooperating with CDK5}, volume = {12}, year = {2025}, }
• (2025). Simultaneous multi-resonant thermally activated delayed fluorescence and room temperature phosphorescence from biluminescent nitrogen-containing indolocarbazoles. ADVS, 12(29), e03175. (www)

  @article{ , abstract = {Organic biluminescence, the simultaneous emission from both the singlet and triplet excited state manifolds, is a rare and incompletely understood emission process. However, biluminescent compounds have wide-reaching applications, such as in sensing, anti-counterfeiting, and optoelectronics, owing to the complex interplay of excited states having distinct spectral profiles and lifetimes. Herein, the biluminescence of a family of polycyclic aromatic heterocycles known as nitrogen-containing indolocarbazoles ( NICz ) is described. As 1 wt.% doped films in polymethylmethacrylate (PMMA), these compounds exhibit dual fluorescence/room temperature phosphorescence (RTP) with λ PL in the near-UV ( ≈ 375 nm) and green ( ≈ 500 nm), respectively, and remarkably long phosphorescence lifetimes extending into the multi-second regime. This RTP is shown to persist even at doping concentrations as low as 0.1 wt.%. Additionally, two of the emitters exhibit multi-resonant thermally activated delayed fluorescence (MR-TADF)/RTP biluminescence, which, to the best of knowledge, would be the first examples of such behavior. Finally, insight is provided into the dependence of these competing emission pathways on the temperature and concentration, with supporting wavefunction-based computations.}, archive = {J_ADVS}, author = {Oliver S. Lee and Aidan P. McKay and David B. Cordes and Stuart L. Warriner and Malte C. Gather and Eli Zysman-Colman}, doi = {10.1002/advs.202503175}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e03175}, shortjournal = {Adv. Sci.}, title = {Simultaneous multi-resonant thermally activated delayed fluorescence and room temperature phosphorescence from biluminescent nitrogen-containing indolocarbazoles}, volume = {12}, year = {2025}, }
• (2025). Perovskite-graphene heterostructure biosensor integrated with biotunable nanoplasmonic ternary logic gate for ultrasensitive cytokine detection. ADVS, 12(29), e03124. (www)

  @article{ , abstract = {The integration of 2D-materials and optoelectronic devices has attracted great attention for advanced applications. We propose the first perovskite/graphene heterostructure-based FET biosensor with uniquely biotunable ternary logic gating functionality. The biosensor integrates a lateral perovskite-on-graphene heterostructure phototransistor with a vertical bio-nano-photonic filter, with a decoupled construction inset. In the phototransistor, photoactive perovskite quantum dots (PQDs) serve as sensitizers to absorb light while a high mobility single-layer graphene (SLG) acts as an expressway for carrier transport. In the bio-nano-photonic filter, a localized surface plasmon resonance (LSPR) is induced by gold nanoparticles (AuNPs) in conjunction with antigen-antibody binding, tuning the delivery of light passing through the filter and facilitating biotunable functionality with ternary modes. The biosensor is set up to detect human interleukin-6 (IL6) in order to determine and achieve ultrahigh sensitivity with a limit of detection (LOD) of 0.9 fg mL −1 (43 aM), which is 4 orders of magnitude greater than graphene-FET biosensors. This ultrahigh sensitivity is achieved due to the synergistic effect of PQDs/SLG heterostructure, exhibiting superior electrical, optical, and physicochemical properties, consequently providing significantly high performance of the biosensor in terms of label-free, ultrahigh sensitivity (attomolar level), rapid responsivity (5 min), excellent stability, and selectivity. This heterostructure-based biotunable configuration could open a new avenue for 2D materials in the realm of next-generation bio-nano-photonic platforms for applications in healthcare, early diagnosis, and rapid detection.}, archive = {J_ADVS}, author = {Jiaxing Sun and Lin Zhou and Zening Li and Guolin He and Hongju Mao and Jianlong Zhao and John A. Hunt and Xianfeng Chen}, doi = {10.1002/advs.202503124}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e03124}, shortjournal = {Adv. Sci.}, title = {Perovskite-graphene heterostructure biosensor integrated with biotunable nanoplasmonic ternary logic gate for ultrasensitive cytokine detection}, volume = {12}, year = {2025}, }
• (2025). Carbon hollow fiber penetration electrode with unsaturated ni-n2 coordination for enhanced CO2 electroreduction. ADVS, 12(29), e02947. (www)

  @article{ , abstract = {Hollow fiber gas penetration electrodes with a compact hierarchical pore structure have emerged as promising platforms for CO 2 electroreduction. However, developing carbon hollow fiber electrodes with efficient CO 2 electrocatalytic performance remains unexplored and challenging. Herein, a straightforward strategy is presented to fabricate robust, self-standing carbon hollow fiber electrodes modified with an unsaturated Ni-N 2 coordination structure. This unique hollow fiber electrode configuration effectively enhances the kinetics of CO 2 electro-conversion to CO. Both density functional theory (DFT) calculations and experimental studies reveal that the Ni-N 2 structure significantly boosts electrocatalytic activity for CO 2 reduction by reducing the energy barrier for the key intermediate COOH* formation. Consequently, the electrode with unsaturated Ni-N 2 coordination realizes a high CO Faradaic efficiency (FE) (>90%) as well as a partial current density of 61 mA cm −2 , much superior to those of saturated Ni-N 4 coordination. In particular, this high performance maintains an exceptional durability for over 100 h, outperforming previously reported carbon supporting electrodes featuring Ni-N-C sites. This work opens new avenues for designing advanced carbon electrode structures with enhanced selectivity and activity for CO 2 reduction.}, archive = {J_ADVS}, author = {Xiaotong Wang and Yiheng Wei and Yanfang Song and Jianing Mao and Xiaohu Liu and Shoujie Li and Guihua Li and Huanyi Zhu and Jiayu Xia and Cheng Luo and Aohui Chen and Xiao Dong and Wei Wei and Wei Chen}, doi = {10.1002/advs.202502947}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e02947}, shortjournal = {Adv. Sci.}, title = {Carbon hollow fiber penetration electrode with unsaturated ni-n2 coordination for enhanced CO2 electroreduction}, volume = {12}, year = {2025}, }
• (2025). Nano-anesthetics regulate neuro-immune interaction for treating neuropathic pain. ADVS, 12(29), e02920. (www)

  @article{ , abstract = {Neuropathic pain is a multifaceted syndrome posing significant challenges to patient quality of life and healthcare systems. Conventional treatments primarily focus on general pain modulation, which fail to address specific underlying mechanisms, leading to limited efficacy and infinite side effects. Calcitonin gene-related peptide (CGRP) has played a pivotal role in neuro-immune repair, contributing to vasodilation, nociception, and immune modulation following tissue injury. Herein, a bupivacaine-loaded cerium-based metal–organic framework (CUB) is designed to integrate sustained release of analgesia with immunomodulatory and antioxidant capabilities. In vivo models of chronic constriction injury (CCI) have demonstrated that CUB significantly reduced neuroinflammation, promoted M2 microglial polarization, and enhanced myelin regeneration for the prolonged analgesia. Deep mechanism analysis revealed that the designed CUB can significantly elevate TSP-1 expression to activate CGRP signal in modulating the neuro-immune interaction, contributing to the repair process. Notably, the CUB outperformed standalone bupivacaine or cerium nanoparticles in terms of pain relief, motor function recovery, and neuroglial regulation. The findings highlight the potential of CUB as a multifactorial therapeutic for treating neuropathic pain, offering new perspectives on the integration of nanotechnology in chronic pain management through neuro-immune pathways.}, archive = {J_ADVS}, author = {Yue Wang and Xiuru Ji and Yu Sun and Han Wang and Ting Wang and Tao Luo and Yanyong Cheng and Jia Yan and Dalong Ni and Hong Jiang}, doi = {10.1002/advs.202502920}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e02920}, shortjournal = {Adv. Sci.}, title = {Nano-anesthetics regulate neuro-immune interaction for treating neuropathic pain}, volume = {12}, year = {2025}, }
• (2025). Discovery to engineering of mycotoxin deoxynivalenol degrading enzymes based on the specialized glyoxalase i. ADVS, 12(29), e02914. (www)

  @article{ , abstract = {Deoxynivalenol (DON) is a mycotoxin that is omnipresent in food and feed. Therefore, this study has focused on discovery, molecular characterization, and engineering of DON degrading enzymes, based on a DON isomerizing enzyme (e.g., the specialized glyoxalase I from Gossypium raimondii (Gr-SPG)). A molecular phylogeny-based sequence and structure analysis elucidated the evolutionary trajectory of the DON degrading enzymes. Ancestral sequence reconstruction led to the generation of thermostable evolutionary intermediates of SPG (e.g., Anc216). Molecular modeling and consensus protein design allowed to understand the structure and function relationships and also identify the key conserved mutations that influence catalytic activity and thermostability. Ultimately, a highly active and thermostable SPG (e.g., a quintuple mutant of Anc216 (Anc216_M5)) was constructed from a newly discovered extant SPG enzyme (OR9). The Anc216_M5 exhibited a of 68 °C, which is 16.3 °C higher than that of the wild-type enzyme. Furthermore, the engineered enzyme showed 40% greater DON degrading activity than OR9, which is significantly higher than that of Gr-SPG. Therefore, it is assumed that Anc216_M5 is promising as a DON-detoxifying biocatalyst.}, archive = {J_ADVS}, author = {Seung Hee Lee and Song Lim Ham and Kyoungmi Oh and Hyojin Park and Young-Seo Kang and Tae-Joo Yang and Taekyung Kim and Jonghwan Kim and Gyu Sung Lee and Min-Jeong Lee and Jin-Byung Park and Chung Sub Kim and Nam Yoon Kim}, doi = {10.1002/advs.202502914}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e02914}, shortjournal = {Adv. Sci.}, title = {Discovery to engineering of mycotoxin deoxynivalenol degrading enzymes based on the specialized glyoxalase i}, volume = {12}, year = {2025}, }
• (2025). Imprinting electrically switchable scalar spin chirality by anisotropic strain in a kagome antiferromagnet. ADVS, 12(29), e02569. (www)

  @article{ , abstract = {Topological chiral antiferromagnets, such as Mn 3 Sn, are emerging as promising materials for next-generation spintronic devices due to their intrinsic transport properties linked to exotic magnetic configurations. Here, it is demonstrated that anisotropic strain in Mn 3 Sn thin films offers a novel approach to manipulate the magnetic ground state, unlocking new functionalities in this material. Anisotropic strain reduces the point group symmetry of the manganese (Mn) Kagome triangles from C 3 v to C 1 , significantly altering the energy landscape of the magnetic states in Mn 3 Sn. This symmetry reduction enables even a tiny in-plane Dzyaloshinskii-Moriya (DM) interaction to induce canting of the Mn spins out of the Kagome plane. The modified magnetic ground state introduces a finite scalar spin chirality and results in a significant Berry phase in momentum space. Consequently, a large anomalous Hall effect emerges in the Kagome plane at room temperature - an effect that is absent in the bulk material. Moreover, this twofold degenerate magnetic state enables the creation of multiple-stable, non-volatile anomalous Hall resistance (AHR) memory states. These states are field-stable and can be controlled by thermal-assisted current-induced magnetization switching, requiring modest current densities and small bias fields, thereby offering a compelling new functionality in Mn 3 Sn for spintronic applications.}, archive = {J_ADVS}, author = {Debjoty Paul and Shivesh Yadav and Shikhar Gupta and Bikash Patra and Nilesh Kulkarni and Debashis Mondal and Kaushal Gavankar and Sourav K. Sahu and Biswarup Satpati and Bahadur Singh and Owen Benton and Shouvik Chatterjee}, doi = {10.1002/advs.202502569}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e02569}, shortjournal = {Adv. Sci.}, title = {Imprinting electrically switchable scalar spin chirality by anisotropic strain in a kagome antiferromagnet}, volume = {12}, year = {2025}, }
• (2025). Targeted dual-responsive liposomes co-deliver jolkinolide b and ce6 to synergistically enhance the Photodynamic/Immunotherapy efficacy in gastric cancer through the PANoptosis pathway. ADVS, 12(29), e02289. (www)

  @article{ , abstract = {Improving the efficacy of gastric cancer (GC) treatment remains an ongoing challenge. Considering the increasing importance of PANoptosis, a novel form of programmed cell death, the current study integrates photodynamic therapy (PDT) and chemodynamic therapy (CDT) into nanoliposomes. This approach utilizes the ability of photosensitizer Chlorin e6 (Ce6) to generate reactive oxygen species (ROS) and the function of the natural targeting agent Jolkinolide B to activate the PANoptosis molecular switch, inducing the ROS-caspase8/PANoptosis pathway to promote GC cell death. The designed CJP–TiN liposome targets GC via internalizing RGD peptide (iRGD), and demonstrates ROS/pH dual responsiveness in the tumor microenvironment. In vitro and in vivo experiments show effective ROS generation ability under light exposure, killing tumor cells and triggers thioether bond cleavage for dual-controlled drug release. The combined therapy enhances antitumor effect, converting “cold tumors” into “hot tumors,” thereby enhancing the success of immunotherapy. The role of CJP–TiN as a PANoptosis inducer in the tumor microenvironment is confirmed, thereby expanding its application potential as a molecularly targeted therapy for GC treatment, and providing a novel perspective for therapeutic strategies.}, archive = {J_ADVS}, author = {Chenhui Ma and Lei Gao and Kewei Song and Baohong Gu and Bofang Wang and Yang Yu and Xueyan Wang and Xuemei Li and Jike Hu and Weigao Pu and Yunpeng Wang and Na Wang and Dedai Lu and Zhijian Han and Hao Chen}, doi = {10.1002/advs.202502289}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e02289}, shortjournal = {Adv. Sci.}, title = {Targeted dual-responsive liposomes co-deliver jolkinolide b and ce6 to synergistically enhance the Photodynamic/Immunotherapy efficacy in gastric cancer through the PANoptosis pathway}, volume = {12}, year = {2025}, }
• (2025). Novel cyano-artemisinin dimer ZQJ29 targets PARP1 to induce ferroptosis in pancreatic cancer treatment. ADVS, 12(29), e01935. (www)

  @article{ , abstract = {Pancreatic cancer remains one of the most lethal malignancies in the digestive system, with limited available drugs and a need for improved efficacy. This unmet clinical need highlights the urgency to discover novel, highly efficient small-molecule compounds. Herein, a novel cyano-containing artemisinin dimer derivative, ZQJ29, is synthesized through structural modifications of artemisinin. Biological evaluation demonstrated that ZQJ29 effectively inhibits the proliferation of pancreatic cancer cells both in vitro and in vivo. ZQJ29 selectively targets PARP1 and has distinct structural features comparable to established PARP1 inhibitors such as Olaparib. Notably, ZQJ29 is the first reported artemisinin derivative to inhibit PARP1. Furthermore, the inhibition of PARP1 by ZQJ29 enhances the expression of TP53 and inhibits the SLC7A11/GPX4 pathway. The work first demonstrates that targeting PARP1 can induce ferroptosis in pancreatic cancer. These findings not only identify promising artemisinin derivatives for the development of therapies targeting pancreatic cancer but also provide scientific evidence supporting therapeutic strategies aimed at inducing ferroptosis in pancreatic cancer. This research lays a robust foundation for subsequent preclinical studies.}, archive = {J_ADVS}, author = {Jianping Chen and Lingyun Yue and Yanna Pan and Bingying Jiang and Junfeng Wan and Haixia Lin and Fujiang Guo and Huiyu Li and Yajuan Li and Qingjie Zhao}, doi = {10.1002/advs.202501935}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e01935}, shortjournal = {Adv. Sci.}, title = {Novel cyano-artemisinin dimer ZQJ29 targets PARP1 to induce ferroptosis in pancreatic cancer treatment}, volume = {12}, year = {2025}, }
• (2025). Novel ATR/PARP1 dual inhibitors demonstrate synergistic antitumor efficacy in triple-negative breast cancer models. ADVS, 12(29), e01916. (www)

  @article{ , abstract = {Concomitant inhibition of ataxia telangiectasia and Rad3-related protein (ATR) and poly ADP-ribose Polymerase (PARP) pathways is a promising strategy in cancer therapy, potentially expanding the clinical utility of ATR inhibitor (ATRi) and PARP inhibitor (PARPi). A novel series of ATR/PARP1 dual inhibitors is developed through the pharmacophore fusion of AZD6738 and Olaparib. Among them, B8 emerges as the most promising candidate, exhibiting potent ATR (IC 50 : 17.3 nM) and PARP1 (IC 50 : 0.38 nM) inhibition. B8 effectively reduced cell viability, induced apoptosis, and caused G2/M cell cycle arrest in TNBC cells. Additionally, B8 significantly impaired TNBC colony formation, migration, and invasion. Mechanistically, B8 induces DNA damage, evidenced by increased γ H2AX levels. In in vivo studies, B8 suppressed tumor growth more effectively than the combination in MDA-MB-468 xenografted mice, with no significant body weight loss. B8 also enhanced γ H2AX expression in tumor tissues. These findings confirm the synergistic effects of ATR/PARP1 co-inhibition and highlight the potential of this novel inhibitor class for TNBC therapy.}, archive = {J_ADVS}, author = {Yuan Gao and Jiawei Zhou and Chen-Chen Wang and Zong-Hao Wang and Nian-Dong Mao and Meng-Lan He and Peng-Peng Zhang and Ping Huang and Guo-Wei Ye and Yu-Qing Zhang and Feng-Hui Tang and Hang Zhang and Tian Xie and Xiang-Yang Ye}, doi = {10.1002/advs.202501916}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e01916}, shortjournal = {Adv. Sci.}, title = {Novel ATR/PARP1 dual inhibitors demonstrate synergistic antitumor efficacy in triple-negative breast cancer models}, volume = {12}, year = {2025}, }
• (2025). Secondary electron hyperspectral imaging of carbons: New insights and good practice guide. ADVS, 12(29), e01907. (www)

  @article{ , abstract = {Energy storage technologies such as lithium-ion batteries (LIBs) incorporate carbon components key to their function. Graphite and carbon binder components in LIB electrodes are engineered to deliver critical electrical and mechanical properties, as are the surface chemistry and morphology of carbon blacks (CBs) in LIBs and catalysts. The challenge of relating surface chemistry to morphology is complicated by the numerous forms of carbon bonding and potential for surface functional groups. Furthermore, materials processing can influence bonding and structure of carbon at multiple length scales, as seen in mechanochemical functionalization of CBs. To understand the nature of carbon surfaces, secondary electron hyperspectral imaging (SEHI) is introduced as a spatially resolved analysis bridging the nano to microscale. The ability to provide novel insights is demonstrated three example applications: observation of nanoscale “satellite” particles of amorphous hydrogenated carbon on graphitic CB particles, differentiation between graphitic and amorphous hydrogenated nano-thickness carbon coatings on particles of lithium iron phosphate, and differentiation between graphitic carbon active material and carbon binder domain in a LIB anode material. SEHI analysis using peak fitting models for graphitic and disordered carbons is developed based on reference materials and standard spectroscopic methods: Raman spectroscopy and X-ray photoelectron spectroscopy.}, archive = {J_ADVS}, author = {James F. Nohl and Nicholas T.H. Farr and Maria Rosaria Acocella and Alexander J. Knight and Gareth M. Hughes and Jingqiong Zhang and Stuart Robertson and Stuart Micklethwaite and Sean Murphy and Tereza Motlová and Christopher Walker and Alexander I. Tartakovskii and Filip Mika and Zuzana Pokorná and Steve Tear and Andrew Pratt and Nancy L. Ford and Nicole Hondow and Mark A. E. Jepson and Lyudmila S. Mihaylova and Nik Reeves-McLaren and Serena A. Cussen and Cornelia Rodenburg}, doi = {10.1002/advs.202501907}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e01907}, shortjournal = {Adv. Sci.}, title = {Secondary electron hyperspectral imaging of carbons: New insights and good practice guide}, volume = {12}, year = {2025}, }
• (2025). Single cu atoms anchored energetic COFs as combustion catalytic promoters toward rapid and concentrated thermal decomposition of ammonium perchlorate. ADVS, 12(29), e01761. (www)

  @article{ , abstract = {Achieving a synergistic, rapid, and concentrated energy release process of ammonium perchlorate (AP) is of vital significance for boosting the thrust of composite solid propellants. However, conventional catalytic promoters often exhibit suboptimal catalytic kinetics due to inefficient utilization of active sites. Herein, atomically dispersed Cu-coordinated covalent organic frameworks (COFs)-based catalytic promoters are reported, decorating with energetic anion groups. The highly accessible single Cu sites confined in the COFs significantly contribute to the raid and concentrated energy release of AP, yielding a sharply narrowed decomposition peak at 341.3 °C with a peak width of only 9 °C. This performance is markedly superior to the dispersed exothermic process of raw AP (410.3 °C with a peak width of 30 °C). Additionally, the energetic COF promoter considerably increased the output energy via collaboratively promoting the chemical energy release of AP and its own decomposition. Correlating in situ spectroscopies and theoretical calculations reveals that the incorporated anionic groups effectively modulate the local electronic structure of the Cu sites. This alteration promotes the key step of cleavage of Cl─O bonds in AP intermediates to produce reactive oxygen species and also boosts the oxidation of NH 3 to high-valence nitrogen oxides, thereby accelerating the combustion reaction kinetic.}, archive = {J_ADVS}, author = {Meng Zhang and Shan Wang and Xu-Yang Wang and Zhi-Peng Wu and Bai-Suo Ding and Li Yang and Wen-Chao Tong and Qinglang Ma and Qian-You Wang}, doi = {10.1002/advs.202501761}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e01761}, shortjournal = {Adv. Sci.}, title = {Single cu atoms anchored energetic COFs as combustion catalytic promoters toward rapid and concentrated thermal decomposition of ammonium perchlorate}, volume = {12}, year = {2025}, }
• (2025). Tailored crystallization dynamics for efficient and stable DMSO-free tin perovskite solar cells. ADVS, 12(29), e01311. (www)

  @article{ , abstract = {Tin perovskite solar cells are emerging as a sustainable lead-free alternative in thin film photovoltaics. DMSO-free processed tin perovskites are gaining interest due to the detrimental effects of DMSO on tin oxidation. However, replacing DMSO with other solvents remains challenging due to the accelerated crystallization dynamics in non-DMSO systems. In this study, the crystallization process in a DMSO-free solvent system is regulated by managing the transition from the sol-gel phase to the solid film. Specifically, piperazine dihydriodide (PDAI) and 4- tert -butylpyridine (tBP) are utilized to coordinately tune the colloidal chemistry through forming large pre-nucleation clusters in perovskite ink, further, facilitating the film formation process. By combining tBP and PDAI, a controllable crystallization rate is achieved as evidenced by in situ photoluminescence (PL) measurement during spin-coating. As a result, tin perovskite films show high crystallinity and improved microstructure. Devices treated with tBP+PDAI exhibit a champion power conversion efficiency of 7.8% and excellent stability without observable degradation for over 3000 h stored in the N 2 glovebox. These findings advance understanding and managing crystallization in DMSO-free solvents processed tin perovskite solar cells.}, archive = {J_ADVS}, author = {Shengnan Zuo and Alexander Tarasov and Lennart Frohloff and Karunanantharajah Prashanthan and Florian Ruske and Mailis Lounasvuori and Chiara Frasca and André Dallmann and Fengshuo Zu and Florian Mathies and Florian Scheler and Noor Titan Putri Hartono and Guixiang Li and Jinzhao Li and Maxim Simmonds and Wenhui Li and Norbert Koch and Steve Albrecht and Meng Li and Eva Unger and Mahmoud Hussein Aldanmasy and Artem Musiienko and Antonio Abate}, doi = {10.1002/advs.202501311}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e01311}, shortjournal = {Adv. Sci.}, title = {Tailored crystallization dynamics for efficient and stable DMSO-free tin perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Generation of neural organoids and their application in disease modeling and regenerative medicine. ADVS, 12(29), e01198. (www)

  @article{ , abstract = {The complexity and precision of the human nervous system have posed significant challenges for researchers seeking suitable models to elucidate refractory neural disorders. Traditional approaches, including monolayer cell cultures and animal models, often fail to replicate the intricacies of human neural tissue. The advent of organoid technology derived from stem cells has addressed many of these limitations, providing highly representative platforms for studying the structure and function of the human embryonic brain and spinal cord. Researchers have induced neural organoids with regional characteristics by mimicking morphogen gradients in neural development. Recent advancements have demonstrated the utility of neural organoids in disease modeling, offering insights into the pathophysiology of various neural disorders, as well as in the field of neural regeneration. Developmental defects in neural organoids due to the lack of microglia or vascular systems are addressed. In addition to induction methods, microfluidics is used to simulate the dynamic physiological environment; bio-manufacturing technologies are employed to regulate physical signaling and shape the structure of complex organs. These technologies further expand the construction strategies and application scope of neural organoids. With the emergence of new material paradigms and advances in AI, new possibilities in the realm of neural organoids are witnessed.}, archive = {J_ADVS}, author = {Ruiqi Huang and Feng Gao and Liqun Yu and Haokun Chen and Rongrong Zhu}, doi = {10.1002/advs.202501198}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e01198}, shortjournal = {Adv. Sci.}, title = {Generation of neural organoids and their application in disease modeling and regenerative medicine}, volume = {12}, year = {2025}, }
• (2025). High-efficiency carriers’ separation strategy based ultrasmall-bandgap CuWO4 sono-enhances GSH antagonism for cuproptosis cascade immunotherapy. ADVS, 12(29), e00576. (www)

  @article{ , abstract = {The spatiotemporal sequential treatment strategy of promoting rapid separation of charge carriers, amplifying oxidative stress, increasing the low content of intracellular Cu, enhancing cuproptosis, and cascading activation of immunotherapy is considered one of the most effective techniques for improving the comprehensive therapy of tumors. Herein, copper tungstate (CuWO₄, CWO) nanoparticles with ultrasmall bandgap (1.71 eV) is developed as both piezoelectric-catalysis agents and copper nanocarriers for synergistic sono-enhanced cuproptosis. Owing to the unique bandgap microstructure, exposure to ultrasound (US) significantly increase the generation of reactive oxygen species (ROS) and the release of Cu 2+ from CWO. Additionally, ≈60% of glutathione (GSH) and nicotinamide adenine dinucleotide phosphate (NADPH) are consumed in situ, leading to oxidative stress, ferroptosis, and cuproptosis in cancer cells. This cascading approach induces substantial mitochondrial dysfunction and the release of damage-associated molecular patterns (DAMPs), which promotes immunogenic cell death (ICD) and augments antitumor immunity. Both in vitro and in vivo studies have shown that this sono-enhanced cuproptosis-based therapy could effectively suppress tumor growth. Overall, this study investigates a novel Structure-Function therapeutic approach that combines piezoelectric catalysis, ferroptosis, cuproptosis, and cascade activation of immune regulation, opening up new possibilities for addressing the challenges associated with conventional cuproptosis therapy.}, archive = {J_ADVS}, author = {Lichao Zhu and Zhisheng Guo and Yu Luo and Haiyan Huang and Kexin Zhang and Bingbing Duan and Renmiao Peng and Haochen Yao and Chao Liang and Kaiyang Wang}, doi = {10.1002/advs.202500576}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e00576}, shortjournal = {Adv. Sci.}, title = {High-efficiency carriers’ separation strategy based ultrasmall-bandgap CuWO4 sono-enhances GSH antagonism for cuproptosis cascade immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Enhanced catalytic cycle of glucose oxidation and reactive species with ROS and RHS generation mediated by galvanic engineering of dual atomic sites on covalent organic frameworks demonstrating synergistic bimetal tumor treatment. ADVS, 12(29), e00515. (www)

  @article{ , abstract = {This study introduces a novel approach to cancer treatment using covalent organic frameworks (COFs) with dual atomic metal sites, employing a galvanic reaction to integrate both gold (Au) and iridium (Ir) onto COF (COF/Au x /Ir 1-x ). The integration of these metals enables a synergistic catalytic cycle that enhances glucose oxidation and the generation of reactive oxygen species (ROS) and reactive halogen species (RHS). Au catalyzes glucose oxidation, producing gluconic acid and hydrogen peroxide (H₂O₂), while Ir decomposes H₂O₂ into superoxide anion (O₂⁻) and, in the presence of chloride ions (Cl⁻), generates hypochlorous acid (HOCl). The dual metal atomic sites facilitate a feedback cycle where H₂O₂ is efficiently converted back to oxygen (O₂), amplifying ROS and RHS generation within cancer cells. By fine-tuning the Au: Ir ratio through the galvanic reaction, optimal catalytic performance is achieved, creating a highly effective tumor treatment strategy. This work represents the first application of dual metal atomic sites on COFs for cancer therapy, demonstrating significant potential for catalysis-based biomedical applications. The synergistic interactions between Au and Ir enhance catalytic efficiency, offering a new approach to exploiting endogenous cancer cell metabolites for targeted and efficient cancer treatment.}, archive = {J_ADVS}, author = {Wei-Chung Pan and Cheng-Hung Luo and Wen-Ling Lin and Liu-Chun Wang and Divinah Manoharan and Po-Ya Chang and Hwo-Shuenn Sheu and Chen-Hao Yeh and Chia-Jui Yen and Chen-Sheng Yeh}, doi = {10.1002/advs.202500515}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {e00515}, shortjournal = {Adv. Sci.}, title = {Enhanced catalytic cycle of glucose oxidation and reactive species with ROS and RHS generation mediated by galvanic engineering of dual atomic sites on covalent organic frameworks demonstrating synergistic bimetal tumor treatment}, volume = {12}, year = {2025}, }
• (2025). Macroscopic structural transition of nickel dithiolate capsule with uniaxial magnetic anisotropy in water. ADVS, 12(29), 2504967. (www)

  @article{ , abstract = {Meeting the Internet of Things (IoT) demand for flexible organic spintronics requires dynamically flexible, “soft” organic magnetic materials. These materials should be capable of reordering their macroscopic assemblies in response to external stimuli. Unlike conventional rigid, “hard” crystalline organic paramagnets, that are typically composed of open-shell π- or d/π-conjugated planar molecules and rely on intermolecular interactions in the ordered, assembled structures, soft paramagnets necessitate a delicate balance between long-range structural order (essential for controlling magnetic properties) and dynamic flexibility a challenge previously unmet for open-shell planar molecules. In this study, an amphiphilic d/π-conjugated nickel dithiolate radical anion salt is presented that self-assembles into ordered membranes, forming capsule-like macrostructures with exceptional stability in aqueous environments. This design achieves the desired balance. These assemblies exhibit uniaxial magnetic anisotropy driven by significant spin–spin interactions and undergo temperature-dependent macroscopic structural transitions representing, to the knowledge, the first observation of such behavior for assemblies of open-shell planar molecules. This well-defined, single-molecular-weight system provides critical structural and mechanism insights for soft matter design and a versatile platform for spintronic applications. The findings advance the development of flexible, tunable molecular soft paramagnets, expanding their potential for innovative applications in flexible devices and beyond.}, archive = {J_ADVS}, author = {Tomoko Fujino and Mafumi Hishida and Masatoshi Ito and Toshikazu Nakamura and Mizue Asada and Naoya Kurahashi and Hisao Kiuchi and Yoshihisa Harada and Koji Harano and Rie Makiura and Kanokwan Jumtee Takeno and So Yokomori and Hiroshi Oike and Hatsumi Mori}, doi = {10.1002/advs.202504967}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2504967}, shortjournal = {Adv. Sci.}, title = {Macroscopic structural transition of nickel dithiolate capsule with uniaxial magnetic anisotropy in water}, volume = {12}, year = {2025}, }
• (2025). From ancient techniques to modern solutions: In situ synthesis of C-S-H for sandstone conservation. ADVS, 12(29), 2503333. (www)

  @article{ , abstract = {Hydraulic calcium-silicate-hydrate (C-S-H), a key binding agent in both ancient mortars and modern cement, holds significant promise for heritage conservation. Drawing inspiration from ancient Roman techniques, this study investigates the development of C-S-H-based grouting materials to address water-induced erosive damage in the Beishan Grottoes of the Dazu Rock Carvings. The interfacial interactions between C-S-H mortar and sandstone are analyzed using molecular dynamics simulations, revealing the crucial role of hydrogen bonding at the interface of C-S-H and mineral phases for adhesion. In the in situ synthesis of C-S-H with a reticulated structure from Ca(OH) 2 /silica fume mixtures under ambient conditions, this work systematically investigates the impact of varying calcium-to-silica (C/S) ratio and water-to-binder ratios on the mechanical properties and pore structure of C-S-H-based mortars. The optimal mechanical and physical properties are achieved with a C/S ratio of 0.8, water/binder ratio of 2.0, binder/aggregate ratio of 1:3, and 4 wt% polycarboxylate superplasticizer. Laboratory-scale experiments confirm its excellent compatibility with sandstone, offering a potential effective grouting solution for the Beishan Grottoes and emphasizing the importance of material compatibility in heritage conservation. This integrated approach encompassing materials design, synthesis, characterization, and interfacial analysis, presents a robust framework for developing tailored binding agents for various applications.}, archive = {J_ADVS}, author = {Mengjun Jia and Huimin Yan and Qingqing Xu and Celestino Grifa and Gang Zhao and Siwei Jiang and Jinhua Wang and Zhenhua Wei and Han Liu and Xiao Ma}, doi = {10.1002/advs.202503333}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2503333}, shortjournal = {Adv. Sci.}, title = {From ancient techniques to modern solutions: In situ synthesis of C-S-H for sandstone conservation}, volume = {12}, year = {2025}, }
• (2025). Plasmonic molecular entrapment for label-free methylated DNA detection and machine-learning assisted quantification. ADVS, 12(29), 2503257. (www)

  @article{ , abstract = {Epigenetic DNA methylations are linked to the activation of oncogenes and inactivation of tumor suppressor genes. A reliable and label-free method to quantitatively measure DNA methylation levels is essential for diagnosing and monitoring methylation-related diseases. Herein, plasmonic molecular entrapment (PME) method assisted SERS as facile strategy for trapping and label-free sensing of DNA methylation, utilizing in situ surface growth of plasmonic particle in the presence of target analytes, are developed. This highly sensitive and adaptable technique forms hotspot sites around target analytes, overcoming mismatch geometrical properties and producing a strong electromagnetic field that leads to significant SERS signal enhancement. The PME method effectively profiles and quantifies DNA methylation, demonstrating robust capabilities for DNA analysis. A logistic regression (LR)-based machine learning accurately quantifies and classifies methylation levels in clinical serum samples of colorectal cancer and normal patients with high sensitivity, specificity, and accuracy, highlighting the feasibility of this technique. The developed PME method combined with machine learning offers promising sensing techniques for disease screening and diagnosis, marking a significant advancement in disease detection and patient care.}, archive = {J_ADVS}, author = {Muhammad Shalahuddin Al Ja'farawy and Vo Thi Nhat Linh and Chaewon Mun and Jun-Yeong Yang and Jun Young Kim and Rowoon Park and Sung-Gyu Park and Dong-Ho Kim and Min-Young Lee and Ho Sang Jung}, doi = {10.1002/advs.202503257}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2503257}, shortjournal = {Adv. Sci.}, title = {Plasmonic molecular entrapment for label-free methylated DNA detection and machine-learning assisted quantification}, volume = {12}, year = {2025}, }
• (2025). Fast pH-driven solubilization method of realgar (As4S4) to reduce the toxicity of arsenic [As(III)] for medicinal purposes. ADVS, 12(29), 2502740. (www)

  @article{ , abstract = {Acute promyelocytic leukemia (APL) accounts for 5–15% of acute myeloid leukemia cases. It is typically characterized by the (15;17) chromosomal translocation, producing the pathogenic retinoic acid receptor (RAR) alpha/promyelocytic leukemia (PML) fusion protein. Recently, remission of APL has been achieved using the first chemotherapy-independent oral drug regimen in anticancer therapy, consisting of all-trans retinoic acid (targeting RARalpha) and the arsenic sulfide realgar (targeting PML). However, clinical adoption of realgar and the characterization of its active breakdown products have been hampered by its poor solubility. Here, a scalable pH/temperature-based process is described that partially mimics gut transition, achieving fast and reproducible solubilization of realgar. Six different spectroscopic and spectrometric techniques are employed to investigate solubilized realgar. Furthermore, it is shown that solubilized realgar targets PML, displaying wider in vitro therapeutic indices and lower off-target effects than arsenic trioxide, the current APL standard of care. Moreover, in line with evidence of an interplay between PML and HIV persistence, solubilized realgar can disrupt HIV latency, the main barrier to an HIV/AIDS cure, in CD4 T cells of people living with HIV. These findings may open avenues for streamlining realgar solubilization and designing less toxic, orally administrable arsenic-based therapies.}, archive = {J_ADVS}, author = {Bojana Lucic and Douglas Santana Franciscato and Helton Pereira Nogueira and Lara Gallucci and Alceu Totti Silveira Junior and Asmaa Mohamed Ismail and Millie Robinson and Teresa Dallinger and Claudia Gutfleisch and Jochen Kurz and Maytê Toledo and Jessica Dias da Silva Ferraz and Mohammad Tarek and Danilo Dias and Ricardo Sobhie Diaz and Mahmoud ElHefnawi and Mattia Forcato and Hugo P Monteiro and Marina Lusic and Iart Luca Shytaj and Andrea Savarino}, doi = {10.1002/advs.202502740}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2502740}, shortjournal = {Adv. Sci.}, title = {Fast pH-driven solubilization method of realgar (As4S4) to reduce the toxicity of arsenic [As(III)] for medicinal purposes}, volume = {12}, year = {2025}, }
• (2025). Mixed-dimensional floating gate phototransistors for mixed-modal in-sensor reservoir computing. ADVS, 12(29), 2502694. (www)

  @article{ , abstract = {Novel neuromorphic devices constructed from low-dimensional materials have demonstrated significant potential in visual perception and information processing. Colloidal quantum dots (QDs) exhibit strong light absorption and tunable band gaps, while 2D materials provide smooth interfaces and channels with superior charge carrier mobility. However, the potential of devices utilizing QDs as floating gates and 2D materials as channels remains largely underexplored. Herein, a floating-gate phototransistor based on the mixed-dimensional heterostructure of 0D-CsPbBr 3 QDs and 2D-MoS 2 few layer is introduced. By leveraging the optical advantages of 0D-QDs and the electrical properties of 2D materials, mixed-modal in-sensor reservoir computing (RC) is realized. Upon electrical/optical stimulation, the device demonstrates an on/off ratio of 10 7 , over 7-bit multistates, nonlinear memory decay behavior, and dynamics with tunable time scales. Building upon these characteristics, the device enables mixed-modal RC using mixed-inputs of optical and electrical signals. Furthermore, accurate recognition of endangered species under extreme weather conditions is also demonstrated through audio-visual fusion. This study presents a compelling paradigm for utilizing the properties of different-dimensional materials to achieve mixed-modal information fusion and opens new pathways for mimicking biological multisensory fusion.}, archive = {J_ADVS}, author = {Weilun Ouyang and Qirui Zhang and Jiangang Chen and Xiao Luo and Xuemei Wang and Yingying Chen and Fan Yang and Qi Nie and Qing Liu and Fucai Liu}, doi = {10.1002/advs.202502694}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2502694}, shortjournal = {Adv. Sci.}, title = {Mixed-dimensional floating gate phototransistors for mixed-modal in-sensor reservoir computing}, volume = {12}, year = {2025}, }
• (2025). Large area high-performance thin film solid oxide fuel cell with nanoscale anode functional layer by scalable reactive sputtering. ADVS, 12(29), 2502504. (www)

  @article{ , abstract = {For high-performance thin-film solid oxide cells (TF-SOCs), a nanostructured anode functional layer (n-AFL) that can prolong the triple-phase boundary (TPB) is crucial, particularly for low-temperature operation. However, the implementation of n-AFL (usually >1 µm in thickness) has critical issues in scale-up and productivity. Here, the study successfully demonstrates a large-area, high-performance TF-SOFC with an n-AFL fabricated via mass-production-compatible reactive magnetron sputtering. The cell with optimized n-AFL by adjusting crucial reactive-sputtering process parameters, i.e., oxygen partial pressure and sputtering power, shows superior performance compared to that of the cell without n-AFL: the reduction both in ohmic and anodic polarization resistances by 63% and 34%, respectively, and the improvement in maximum power density by 89% (0.705 W cm −2 vs 1.333 W cm −2 ) at 650 °C. When employed in large-scale cell (4 × 4 cm 2 ), the TF-SOFC with n-AFL showed 19.4 W at 650 °C.}, archive = {J_ADVS}, author = {Kyoungjae Ju and Seongkook Oh and Jong Hyuk Lee and Hyong June Kim and Hyunmin Kim and Sung Eun Jo and Juhwan Lee and Byung Chan Yang and Jisung Yoon and Dong Won Shin and Wanwoo Park and Ji-Won Son and Young-Beom Kim and Sungeun Yang and Jihwan An}, doi = {10.1002/advs.202502504}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2502504}, shortjournal = {Adv. Sci.}, title = {Large area high-performance thin film solid oxide fuel cell with nanoscale anode functional layer by scalable reactive sputtering}, volume = {12}, year = {2025}, }
• (2025). Responsive ROS-augmented prodrug hybridization nanoassemblies for multidimensionally synergitic treatment of hepatocellular carcinoma in cascade assaults. ADVS, 12(29), 2501420. (www)

  @article{ , abstract = {The rapid deterioration and progression of hepatocellular carcinoma (HCC) is intimately associated with copper ion overload, and integrating the cuproptosis mechanism for the treatment of HCC presents a promising prospect. Nevertheless, cell death complexity renders efficient removal of all HCC cells insufficient solely relying on the cuproptosis pathway. Herein, the GSH-responsive prodrug hybridization nanoassembly CA-4S 2 @ES-Cu is exploited, which targets the delivery of copper ions to mitochondria via Elesclomol, contributing to mitochondrial dysfunction and evoking cuproptosis. Simultaneously, CA-4S 2 depletes GSH to release CA-4, disrupting microtubule function and suppressing HCC cell proliferation and angiogenesis, to realize a dual attack against copper ion-mediated deterioration and metastasis of HCC. Furthermore, both in the HCC mouse model synergistically elicit oxidative stress to amplify the cuproptosis effect and release activated immunogenetic cell death to initiate a vigorous antitumor immune response in cascade assault modality. Conclusively, the multilevel synergistic assault penetrates the limitations of single therapy and implements a multidimensional targeted treatment for HCC.}, archive = {J_ADVS}, author = {Yingjie Zeng and Yuening Cao and Senmiao Ren and Chaozheng Zhang and Jianan Liu and Ke Liu and Yan Wang and Hongyu Chen and Fengjiao Zhou and Xiuli Yang and Xian Ge and Tingting Zhang and Tianbao Wang and Yao He and Defang Li and Chuantao Zhang and Jun Lu}, doi = {10.1002/advs.202501420}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2501420}, shortjournal = {Adv. Sci.}, title = {Responsive ROS-augmented prodrug hybridization nanoassemblies for multidimensionally synergitic treatment of hepatocellular carcinoma in cascade assaults}, volume = {12}, year = {2025}, }
• (2025). A bifunctional fibrous scaffold implanted with amorphous Co2P as both cathodic and anodic stabilizer for high-performance Li─S batteries. ADVS, 12(29), 2501153. (www)

  @article{ , abstract = {The shuttling of lithium polysulfides (LiPSs) and the formation of lithium dendrites have substantially impeded the practical application of lithium–sulfur (Li─S) batteries. To simultaneously solve these issues, a porous carbon fibrous scaffold embedded with amorphous Co 2 P (A─Co 2 P) is designed as both a cathodic and anodic stabilizer to construct high-rate and long-life Li─S batteries. The meticulously designed self-supporting membrane with an integrated carbon network and porous structure offers superior conductivity and copious spaces for uniform Li 2 S precipitation in the cathode and Li deposition in the anode. Moreover, the incorporated A─Co 2 P provides abundant unsaturated sites, which can not only facilitate the exposure of active sites but also modulate the electronic configuration for enhanced LiPSs adsorption and catalysis capability. Concurrently, the presence of lithiophilic A─Co 2 P sites also reinforces the stability of Li anode with the suppressed formation of dendrites. The constructed full Li─S batteries deliver a high areal capacity of 6.6 mAh cm −2 with a sulfur loading of 8.5 mg cm −2 and a low capacity decay rate of 0.047% per cycle after 800 cycles. This work provides a simple yet effective strategy to construct practical Li─S batteries by simultaneously addressing LiPSs shuttling and Li dendrite growth.}, archive = {J_ADVS}, author = {Gang Zhao and Tianran Yan and Lei Wang and Cheng Yuan and Tong Chen and Bin Wang and Chen Cheng and Pan Zeng and Yude Su and Liang Zhang}, doi = {10.1002/advs.202501153}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2501153}, shortjournal = {Adv. Sci.}, title = {A bifunctional fibrous scaffold implanted with amorphous Co2P as both cathodic and anodic stabilizer for high-performance Li─S batteries}, volume = {12}, year = {2025}, }
• (2025). Reinforcing stromal cell spheroid through red-light preconditioning for advanced vascularization. ADVS, 12(29), 2500788. (www)

  @article{ , abstract = {Despite the promising potential of stromal cell therapy in treating myocardial infarction (MI), its effectiveness is limited by poor cell retention and engraftment in ischemic environments. This study introduces a novel strategy that combines the preconditioning of human adipose-derived stromal cells (hADSCs) using OLED-based photobiomodulation (OPBM) and culturing these cells into 3D spheroids. The preconditioned 3D spheroids (APCS group) exhibit significantly enhanced angiogenic, arterialized, and tissue remodeling capabilities compared with those of traditional 2D cultures and non-preconditioned spheroids. In vivo transplantation of these spheroids into the border zone of infarcted area significantly improve cardiac function and reduce adverse remodeling by enhancing anti-fibrosis and angiogenesis including arterialization. The combined strategy with OPBM preconditioning and 3D spheroid culture system can enhance therapeutic potential of hADSCs with multiple paracrine effects for cardiac repair. This novel approach provides next generation of cell therapeutics to overcome the limitation of adult stromal cell therapy in patients with post-MI heart failure.}, archive = {J_ADVS}, author = {Yu-Jin Kim and Hyeok Kim and Dong-Hyun Lee and Yeong Hwan Kim and Jae-Hyun Park and Woo-Sup Sim and Jin-Ju Kim and Kiwon Ban and Soong Ho Um and Hyun Ji Park and Michael E. Davis and Hun-Jun Park and Suk Ho Bhang}, doi = {10.1002/advs.202500788}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2500788}, shortjournal = {Adv. Sci.}, title = {Reinforcing stromal cell spheroid through red-light preconditioning for advanced vascularization}, volume = {12}, year = {2025}, }
• (2025). Red blood cell-induced bacterial margination improves microbial hemoadsorption on engineered cell-depleted thrombi, restoring severe bacteremia in rats. ADVS, 12(29), 2417498. (www)

  @article{ , abstract = {Extracorporeal hemoadsorption for treating bacteremia has exhibited limited success due to the lack of a clear strategy for effectively bringing bacterial cells into contact with the surface and universal bacteria-capturing substances. Here, a novel extracorporeal device is reported that can eliminate various intact bacteria from whole blood, employing microfluidic bacterial margination and engineered cell-depleted thrombus (CDT) presenting bacterial adhesin receptors. The critical strain rate of red blood cells (RBCs) (0.83 × 10 −2 ) and the flow path height within about 300 µm required for RBC axial migration in the flows are found. The subsequent RBC-bacteria collisions induced bacterial margination, facilitating their effective capture on the CDT surface on the channel wall. Fibrinogen and fibronectin in CDT are found to primarily contribute to capturing various bacteria. The extracorporeal CDT filters (eCDTF), which integrate all these principles, demonstrate significant depletion of major antibiotic-resistant and human fecal bacteria from the whole blood in vitro. Remarkable reductions in bacterial load and inflammatory markers in the rats lethally infected with methicillin-resistant Staphylococcus aureus are further confirmed, resulting in the restoration from bacteremia following extracorporeal treatment. The demonstration may propose a new design principle for hemoadsorption devices and elucidate the limited success of conventional treatments.}, archive = {J_ADVS}, author = {Bong Hwan Jang and Su Hyun Jung and Seyong Kwon and Sung Jin Park and Joo H. Kang}, doi = {10.1002/advs.202417498}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2417498}, shortjournal = {Adv. Sci.}, title = {Red blood cell-induced bacterial margination improves microbial hemoadsorption on engineered cell-depleted thrombi, restoring severe bacteremia in rats}, volume = {12}, year = {2025}, }
• (2025). An engineered PfAgo with wide catalytic temperature range and substrate spectrum. ADVS, 12(29), 2416631. (www)

  @article{ , abstract = {PfAgo, a thermophilic Argonaute nuclease from Pyrococcus furiosus , is widely used in various fields due to its high DNA-guided DNA cleavage activity. However, its high-temperature-dependent cleavage activity largely restricts its applications in moderate-temperature scenarios. In this study, PfAgo is engineered for cold adaptation based on its ternary complex structure and the attributes of cold-adapted enzymes, yielding a series of variants with better performance at moderate temperatures. Among those, mPfAgo (K617G, L618G) exhibits significantly promoted cleavage activity at 37 °C and a wider catalytic temperature range of 30–95 °C. Its high-temperature cleavage activity is also greatly improved, enabling its application in DNA detection with attomolar sensitivity in the presence of Mg 2+ . Additionally, mPfAgo shows versatile cleavage activities, including DNA cleavage guided by 5′OH-gDNA, 5′P-gDNA, or 5′COOH-gDNA, as well as RNA cleavage with 5′OH-gDNA, 5′P-gDNA, 5′P-gRNA, or 5′COOH-gDNA as guides. Further analysis through far-UV CD spectra and DSF indicates that mPfAgo has a more flexible structure than wild-type PfAgo. Furthermore, this established strategy is applied to engineer TtdAgo, likewise obtaining its variants with enhanced moderate-temperature activity and expanded substrate spectrum. In summary, this work provides a novel method for the rational design of thermophilic Agos, thereby greatly expanding their application scopes.}, archive = {J_ADVS}, author = {Longyu Wang and Xiaochen Xie and Fuyong Huang and Qiang Wei and Tianxin Cai and Na Yu and Shi Chen and Fei Wang and Wanping Chen and Chin-yu Chen and Chunhua Li and Lixin Ma}, doi = {10.1002/advs.202416631}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2416631}, shortjournal = {Adv. Sci.}, title = {An engineered PfAgo with wide catalytic temperature range and substrate spectrum}, volume = {12}, year = {2025}, }
• (2025). A solution-based deposition method enabling pigment blue edible electrochemical transistors. ADVS, 12(29), 2416141. (www)

  @article{ , abstract = {Copper(II) phthalocyanine (CuPc), also known as Pigment Blue 15, is a widely utilized pigment renowned for its exceptional semiconducting properties when refined to electronic-grade purity. Recent studies have confirmed its safety if ingested at doses required for essential active components in edible electronics for advanced gastrointestinal tract monitoring. Since in-body operations impose stringent safety constraints on operational biases, the development of transistors with high transconductance at low voltages is required to ensure adequate amplification gain. This study presents a simple and cost-effective method for producing solution-processed CuPc films characterized by a unique porous microstructure that facilitates efficient volumetric ion uptake and mixed ionic-electronic conductivity in electrolyte-gated devices. These porous films exhibit capacitance 30 times greater than compact CuPc films produced through conventional physical vapor deposition methods. The resulting edible transistors demonstrate On/Off ratios exceeding 10 3 and channel width-normalized transconductance of up to 50 µS mm −1 at 0.8 V, establishing their potential as critical active components in future edible devices. Moreover, the proposed method results in a limited impact of impurities on CuPc charge transport efficiency, thus affecting the purification costs and, crucially, enabling the sourcing of CuPc pigments through recycling and upcycling.}, archive = {J_ADVS}, author = {Alessandro Luzio and Fabrizio M. Ferrarese and Matteo Butti and Alberto D. Scaccabarozzi and Bojan Petrović and Sanja Kojić and Goran Stojanović and Simone Fiorini Granieri and Shubham Tanwar and Adrica Kyndiah and Mario Caironi}, doi = {10.1002/advs.202416141}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2416141}, shortjournal = {Adv. Sci.}, title = {A solution-based deposition method enabling pigment blue edible electrochemical transistors}, volume = {12}, year = {2025}, }
• (2025). Eosinophils-induced lumican secretion by synovial fibroblasts alleviates cartilage degradation via the TGF-β pathway mediated by anxa1 binding. ADVS, 12(29), 2416030. (www)

  @article{ , abstract = {The innate immune response is crucial in the progression of temporomandibular joint osteoarthritis (TMJOA). Yet, the roles of eosinophils in TMJOA remain unclear, underscoring the need for further investigation into their potential impact and mechanism. Addressing the clinical observation that eosinophil numbers in synovial fluid are higher in healthy individuals than in those with TMJOA, the vital regulation of this cell population in TMJOA by using an ovalbumin (OVA)-induced hyper-eosinophilia asthma rats is explored and a rat model of antibody-mediated eosinophil depletion in vivo, and co-culture system of synovial fibroblasts, chondrocytes, and eosinophils in vitro. The abnormal synovial proliferation, cartilage degradation, and subchondral bone erosion are effectively inhibited in OVA-induced asthmatic rats appearing in the local accumulation of eosinophils in the synovium. Conversely, the reduction in synovial eosinophils exacerbated TMJOA in rats treated with TRFK. Mechanistically, the protective effect of eosinophils against TMJOA is attributed to their promotion of Lumican secretion in the synovium, where Lumican binds to Annexin A1 in chondrocytes, inhibits transforming growth factor β2 Annexin A1 and Smad2/3 phosphorylation. These results illustrate OVA/IL-5-induced eosinophils’ crucial role in TMJOA, identifying Lumican as a key anti-TMJOA target. Collectively, these findings revealed the signature and mechanism in eosinophils that stimulate TMJOA resolution.}, archive = {J_ADVS}, author = {Wenqian Chen and Yuwei Zhou and Wenxiu Yuan and Yanjing Ou and Hanyu Lin and Kaixun He and Xueshen Qian and Huachen Chen and Chengchaozi Wang and Jie Lu and Weiping Chen and Dexiong Li and Jiang Chen}, doi = {10.1002/advs.202416030}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2416030}, shortjournal = {Adv. Sci.}, title = {Eosinophils-induced lumican secretion by synovial fibroblasts alleviates cartilage degradation via the TGF-β pathway mediated by anxa1 binding}, volume = {12}, year = {2025}, }
• (2025). De novo reconstruction of 3D human facial images from DNA sequence. ADVS, 12(29), 2414507. (www)

  @article{ , abstract = {Facial morphology is a distinctive biometric marker, offering invaluable insights into personal identity, especially in forensic science. In the context of high-throughput sequencing, the reconstruction of 3D human facial images from DNA is becoming a revolutionary approach for identifying individuals based on unknown biological specimens. Inspired by artificial intelligence techniques in text-to-image synthesis, it proposes Difface, a multi-modality model designed to reconstruct 3D facial images only from DNA. Specifically, Difface first utilizes a transformer and a spiral convolution network to map high-dimensional Single Nucleotide Polymorphisms and 3D facial images to the same low-dimensional features, respectively, while establishing the association between both modalities in the latent features in a contrastive manner; and then incorporates a diffusion model to reconstruct facial structures from the characteristics of SNPs. Applying Difface to the Han Chinese database with 9,674 paired SNP phenotypes and 3D facial images demonstrates excellent performance in DNA-to-3D image alignment and reconstruction and characterizes the individual genomics. Also, including phenotype information in Difface further improves the quality of 3D reconstruction, i.e. Difface can generate 3D facial images of individuals solely from their DNA data, projecting their appearance at various future ages. This work represents pioneer research in de novo generating human facial images from individual genomics information.}, archive = {J_ADVS}, author = {Mingqi Jiao and Jiarui Li and Bingxu Zhong and Siyuan Du and Shuning Li and Manfei Zhang and Qibin Zhang and Zhongming Liang and Fan Liu and Chunman Zuo and Sijia Wang and Luonan Chen}, doi = {10.1002/advs.202414507}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2414507}, shortjournal = {Adv. Sci.}, title = {De novo reconstruction of 3D human facial images from DNA sequence}, volume = {12}, year = {2025}, }
• (2025). Integrating dense genotyping with high-throughput phenotyping empowers the genetic dissection of berry quality and resilience traits in grapevine. ADVS, 12(29), 2412587. (www)

  @article{ , abstract = {Investigating the genetic architecture of important agronomic traits in grapevine, like berry quality and resilience to abiotic stress, has been hampered by bottlenecks in genotyping and phenotyping. To address these limitations, this study aimed to develop innovative tools to unravel the complex polygenic genomic architecture of these traits. Specifically, a high-density 200K single nucleotide polymorphism array is developed and validated its effectiveness by genotyping 471 accessions from three F 1 breeding populations. A high-throughput grape phenotyping tool is developed to accurately capture berry color, shape, and size. By integrating data from the two platforms, associated loci are identified over three growing seasons. Association mapping and haplotype analysis identified novel loci and candidate genes for berry shape ( bHLH017 ), soluble sugars ( ACT ), and organic acids ( ALMT1 and FUSC2 ), as well as vine cold tolerance ( NAC08 ), and fine-mapped the flower sex determination locus. Furthermore, the functional role of NAC08 is validated, demonstrating that it activates the expression of a raffinose synthase gene, thereby increasing raffinose levels and conferring cold tolerance. Together, these augmented tools, the integrated data, and novel loci establish a better foundation for trait aggregation that will enhance breeding efficiency and boost the development of high-quality grape varieties.}, archive = {J_ADVS}, author = {Yuyu Zhang and Yongjian Wang and Michael Henke and Pablo Carbonell-Bejerano and Zemin Wang and Pierre-François Bert and Yi Wang and Huayang Li and Junhua Kong and Peige Fan and Zhanwu Dai and Zhenchang Liang}, doi = {10.1002/advs.202412587}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2412587}, shortjournal = {Adv. Sci.}, title = {Integrating dense genotyping with high-throughput phenotyping empowers the genetic dissection of berry quality and resilience traits in grapevine}, volume = {12}, year = {2025}, }
• (2025). A bead-based quantum dot immunoassay integrated with multi-module microfluidics enables real-time multiplexed detection of blood insulin and glucagon. ADVS, 12(29), 2412185. (www)

  @article{ , abstract = {Analyzing diabetes-related hormones such as insulin and glucagon using conventional enzyme-linked immunosorbent assay (ELISA) has been the gold standard. However, ELISAs have a long sample processing time, including blood serum/plasma preparation which restricts the number of measurement time points, making it difficult to accurately track hormone dynamics in relation to each other and to blood glucose levels. Here, a multi-module microfluidic platform, named quantum dot integrated real-time (QIRT)-ELISA system, that uses a bead-based quantum dot-mediated immunoassay (BQI) to continuously monitor insulin and glucagon in whole blood samples and in a multiplexed setting is demonstrated. The use of BQI simplifies the technical aspect of the system, removes the need for bulky and expensive equipment, and most importantly enhances the sensitivity, specificity, and temporal resolution. Validation experiments measuring levels of insulin and glucagon in rats during glucose tolerance tests demonstrate the accuracy of QIRT-ELISA for simultaneously measuring endogenous hormones within the physiological range during an oral glucose load.}, archive = {J_ADVS}, author = {Hesam Abouali and Sanjana Srikant and Md Fahim Al Fattah and Nicole G. Barra and Darryl Chan and Dayan Ban and Jonathan D. Schertzer and Mahla Poudineh}, doi = {10.1002/advs.202412185}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2412185}, shortjournal = {Adv. Sci.}, title = {A bead-based quantum dot immunoassay integrated with multi-module microfluidics enables real-time multiplexed detection of blood insulin and glucagon}, volume = {12}, year = {2025}, }
• (2025). Rational design of inner ear drug delivery systems. ADVS, 12(29), 2410568. (www)

  @article{ , abstract = {The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well as a huge social burden. Among these patients, hearing loss caused by inner ear lesions accounts for a large proportion. Therefore, treatment of the inner ear is important. Inner ear drug delivery systems, which can reduce the side effects of systemic drug administration by delivering drugs directly to the inner ear, are important in sensorineural hearing loss. Here, the development of inner ear drug delivery systems is focused, including the complex physiological structure that they face, types of drugs delivered, routes of administration, and forms of drug delivery carrier platforms. Recent studies in this process are presented and it is concluded with a summary and outlook on the problems faced and possible solutions.}, archive = {J_ADVS}, author = {Xiayidan Maimaitikelimu and Zhiyan Xuan and Haoyu Ren and Keng Chen and Hui Zhang and Huan Wang}, doi = {10.1002/advs.202410568}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2410568}, shortjournal = {Adv. Sci.}, title = {Rational design of inner ear drug delivery systems}, volume = {12}, year = {2025}, }
• (2025). The reconstruction of peripheral auditory circuit: Recent advances and future challenges. ADVS, 12(29), 2410494. (www)

  @article{ , abstract = {The auditory circuit primarily consists of peripheral auditory organs and auditory neural pathways. Hearing loss (HL), as reported by the World Health Organization, affects more than one in eight people worldwide, often leading to severe dysfunction that detrimentally impacts patients' quality of life. Therefore, auditory reconstruction has emerged as a persistent research hotspot and challenge within the biomedical field. Traditional methods for auditory reconstruction, such as drug therapy, hearing aids, cochlear implants (CIs), and so on. To a certain extent, it can help patients with HL improve their hearing status. However, they possess inherent advantages and limitations. Recent advancements in biomaterials, gene editing, stem cells, organoids, and other technologies have ushered in new prospects for the treatment of hearing impairment. This review focuses on the potential of innovative technologies in biomaterials, stem cells, and gene editing in hearing recovery. It reviews the current research status of inner ear hair cell (HC) regeneration, spiral ganglion neuron (SGN) regeneration, and inner ear organoid construction in the auditory loop. Furthermore, the review discusses the challenges associated with these approaches and explores potential future directions, aiming to furnish a comprehensive reference for both research and clinical applications in the domain of peripheral auditory restoration.}, archive = {J_ADVS}, author = {Zhe Li and Ying Zhang and Zhenyu Xiao and Jieyu Qi}, doi = {10.1002/advs.202410494}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2410494}, shortjournal = {Adv. Sci.}, title = {The reconstruction of peripheral auditory circuit: Recent advances and future challenges}, volume = {12}, year = {2025}, }
• (2025). Presbycusis: Pathology, signal pathways, and therapeutic strategy. ADVS, 12(29), 2410413. (www)

  @article{ , abstract = {Presbycusis, also known as age-related hearing loss (ARHL), is a progressive auditory impairment and ranks among the most prevalent sensory disorders in the elderly population. It is primarily caused by damage to hair cells, degeneration of spiral ganglion neurons, and atrophy of the stria vascularis, which are integral components of the cochlea. While extensive research has been devoted to hair cells and spiral ganglion neurons, this review focuses on the critical role of the stria vascularis in ARHL. The primary function of the stria vascularis is to maintain the endocochlear potential, which is essential for hearing. This review presents an overview of the research concerning the stria vascularis in ARHL, particularly focusing on the application of single-cell transcriptomics to elucidate its role. Furthermore, this review explores relevant signaling pathways and therapeutic strategies for ARHL. By enhancing the understanding of the stria vascularis in ARHL, this review aims to pave the way for personalized treatment and improved strategies for protection and prevention.}, archive = {J_ADVS}, author = {Xiaoxu Zhao and Tian Shen and Shengda Cao and Ziyi Liu and Wendu Pang and Meixuan Li and Jingjing Liu and Wen Li and Yunhao Wu and Chengcheng Liu and Ming Xia and Xiaolong Fu and Cheng Cheng}, doi = {10.1002/advs.202410413}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2410413}, shortjournal = {Adv. Sci.}, title = {Presbycusis: Pathology, signal pathways, and therapeutic strategy}, volume = {12}, year = {2025}, }
• (2025). Long-lasting auditory and vestibular recovery following gene replacement therapy in a novel usher syndrome type 1c mouse model. ADVS, 12(29), 2410063. (www)

  @article{ , abstract = {Usher syndrome type 1C (USH1C) is a genetic disorder caused by mutations in the USH1C gene, which encodes harmonin, a key component of the mechanoelectrical transduction complex in auditory and vestibular hair cells. USH1C leads to deafness and vestibular dysfunction in humans. An Ush1c knockout (KO) mouse model displaying these characteristic deficits is generated in our laboratory. To examine gene replacement therapy (GT) in this model, a synthetic adeno-associated viral vector, Anc80L65 , driving harmonin expression is administered, to the inner ears of Ush1c KO mice at postnatal day 2 (P2). Remarkably, this single treatment significantly improved auditory brainstem response (ABR) thresholds and balance motor function at 1 month post-injection, with these effects persisting for up to 10 months. At 12 months post-treatment, the vestibular function is assessed using the vestibular-ocular reflexes (VOR) and single vestibular afferent recordings. The GT treatment significantly restored both the canal and otolith VORs and increased vestibular afferent spontaneous firing rates and responses to head rotation and translation. These findings provide the first evidence of long-lasting restoration of both the auditory and vestibular functions by GT in a novel mouse model of Usher syndrome, highlighting the potential of GT for treating deficits associated with USH1C.}, archive = {J_ADVS}, author = {Weinan Du and Jun Huang and Aizhen Zhang and Fangfang Zhao and Tianwen Chen and Quinn M. McDermott and Tony Zheng and Haibo Wang and Rongli Zhang and Xiaolin Zhang and Jerome Allison and Hong Zhu and Wu Zhou and Qing Yin Zheng}, doi = {10.1002/advs.202410063}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2410063}, shortjournal = {Adv. Sci.}, title = {Long-lasting auditory and vestibular recovery following gene replacement therapy in a novel usher syndrome type 1c mouse model}, volume = {12}, year = {2025}, }
• (2025). Consequences and mechanisms of noise-induced cochlear synaptopathy and hidden hearing loss, with focuses on signal perception in noise and temporal processing. ADVS, 12(29), 2409322. (www)

  @article{ , abstract = {Noise-induced synaptopathy and relevant hidden hearing loss (NIS and NIHHL) have been a hot topic in hearing research for almost 15 years. The progress is summarized in this review to address the reversibility of the synaptic damage after the initial loss, and the role of functional deficit in the repaired synapses as the reason for hearing impairment in addition to the deafferentiation caused by the synaptic loss, per se. The evidence supporting the synaptic repair is summarized. It is pointed out that coding-in-noise deficit (CIND) may not be the major problem of NIS and NIHHL, since solid evidence supporting the existence of this deficit is not available even in animal studies, as well as in in human reports. Rather, temporal processing deficits are clearly demonstrated in subjects with NIS and potentially NIHHL. The idea of CIND as the major concern in NIHHL is proposed based upon the functional categorization of the auditory nerve (ANF) by spontaneous rate and the biased loss of the ribbon synapses innervation the low-SR ANF. The limitation of this hypothesis is discussed in detail. The review also addresses the difficulty of translating animal data to humans and the need for new research in the future.}, archive = {J_ADVS}, author = {Hui Wang and Steven J Aiken and Jian Wang}, doi = {10.1002/advs.202409322}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2409322}, shortjournal = {Adv. Sci.}, title = {Consequences and mechanisms of noise-induced cochlear synaptopathy and hidden hearing loss, with focuses on signal perception in noise and temporal processing}, volume = {12}, year = {2025}, }
• (2025). GDC: Integration of multi-omic and phenotypic resources to unravel the genetic pathogenesis of hearing loss. ADVS, 12(29), 2408891. (www)

  @article{ , abstract = {Effective research and clinical application in audiology and hearing loss (HL) require the integration of diverse data, yet the absence of a dedicated database impedes understanding and insight extraction in HL. To address this, the Genetic Deafness Commons (GDC) is developed by consolidating extensive genetic and genomic data from 51 public databases and the Chinese Deafness Genetics Consortium. This repository comprises 5 983 613 variants across 201 HL genes, revealing the genetic landscape of HL and identifying six novel mutational hotspots within the DNA-binding domains of transcription factors. Comparative phenotypic analyses highlighted considerable disparities between human and mouse models. Among the 201 human HL genes, 133 exhibit hearing abnormalities in mice; 35 have been tested in mice without exhibiting a hearing loss phenotype; and 33 lack auditory testing data. Moreover, gene expression analyses in the cochleae of mice, humans, and rhesus macaques demonstrated a notable correlation (R 2 0.718–0.752). Utilizing gene expression, function, pathway, and phenotype data, a SMOTE-Random Forest model identified 18 candidate HL genes, including TBX2 , newly confirmed as an HL gene. As a comprehensive and unified repository, the GDC advances audiology research and practice by improving data accessibility and usability, ultimately fostering deeper insights into hearing disorders.}, archive = {J_ADVS}, author = {Hui Cheng and Xuegang Wang and Mingjun Zhong and Jia Geng and Wenjian Li and Kanglu Pei and Jing Wang and Lanchen Wang and Yu Lu and Jing Cheng and Fengxiao Bu and Huijun Yuan}, doi = {10.1002/advs.202408891}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2408891}, shortjournal = {Adv. Sci.}, title = {GDC: Integration of multi-omic and phenotypic resources to unravel the genetic pathogenesis of hearing loss}, volume = {12}, year = {2025}, }
• (2025). Single administration of AAV-mAtp6v1b2 gene therapy rescues hearing and vestibular disorders caused by atp6v1b2-induced lysosomal dysfunction in hair cells. ADVS, 12(29), 2408878. (www)

  @article{ , abstract = {Haploinsufficiency of the ATP6V1B2, a subunit of V-ATPases, underlies genetic disorders including Dominant deafness-onychodystrophy (DDOD), deafness, onychodystrophy, osteodystrophy, mental retardation and seizures (DOORS), and Zimmermann-Laband syndromes, all characterized by congenital hearing loss and onychodystrophy. Effective therapies for ATP6V1B2 -associated hearing loss remain elusive. The study generates a hair cell-specific knockout mouse ( Atp6v1b2 fl/fl ; Atoh1 Cre/+ ) recapitulating the human phenotypes, with pathological features including hair cell loss and abnormal lysosomal morphology and function. To enhance therapeutic precision and minimize toxicity, an optimized adeno-associated virus-inner ear vector incorporating promoter enhancer 3 (AAV-ie-Eh3) is engineered. A single administration of AAV-ie-Eh3-m Atp6v1b2 into the scala media at postnatal days 0–2, prevented hair cell degeneration, restored lysosome morphology, and robustly rescued auditory and vestibular function for at least 24 weeks. The findings highlight the critical role of Atp6v1b2 in lysosomal function and demonstrate AAV-ie-Eh3 as a potent gene delivery tool for inner ear therapy. This study establishes a novel therapeutic paradigm for ATP6V1B2- associated hearing loss and vestibular dysfunction, with significant clinical potential.}, archive = {J_ADVS}, author = {Gege Wei and Shiwei Qiu and Xue Gao and Lu Zheng and Yijin Chen and Ying Ma and Haifeng Feng and Jinyuan Yang and Guojie Dong and Huiyi Nie and Weihao Zhao and Xiaoge Li and Guangqin Wang and Wei Xiong and Pu Dai and Yongyi Yuan}, doi = {10.1002/advs.202408878}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2408878}, shortjournal = {Adv. Sci.}, title = {Single administration of AAV-mAtp6v1b2 gene therapy rescues hearing and vestibular disorders caused by atp6v1b2-induced lysosomal dysfunction in hair cells}, volume = {12}, year = {2025}, }
• (2025). AAVR expression is essential for AAV vector transduction in sensory hair cells. ADVS, 12(29), 2408873. (www)

  @article{ , abstract = {Adeno-associated virus (AAV) vectors are a leading platform for gene therapy. Recently, AAV-mediated gene therapy in the inner ear has progressed from laboratory use to clinical trials, but the lower transduction rates in outer hair cells (OHCs) in the organ of Corti and in vestibular hair cells in adult mice still pose a challenge. OHCs are particularly vulnerable to inner ear insults. In this study, we demonstrated that expression of a key AAV receptor (AAVR, Kiaa0319l , or Au040320 ) in OHCs and vestibular hair cells decreases significantly in mature mice and AAV particles directly interact with AAVR by forming complexes. Consequently, antibody blockage of AAVR significantly inhibits AAV transduction in sensory hair cells in cochlear explants. Moreover, use of AAVR knockout mice confirms inhibition of AAV transduction in sensory hair cells in vivo. Finally, conditional overexpression of AAVR in sensory hair cells of adult mice successfully restores AAV transduction efficiency in OHCs and vestibular hair cells. In conclusion, this strong evidence that AAVR is essential for AAV transduction in sensory hair cells will help to increase the efficacy of future gene therapy in inner ear.}, archive = {J_ADVS}, author = {Fan Wu and Guisheng Chen and Rui Hu and Peiwen Liu and Jintao Lou and Wenji Zhao and Zuhong He and Suhua Sha and Yiqing Zheng}, doi = {10.1002/advs.202408873}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2408873}, shortjournal = {Adv. Sci.}, title = {AAVR expression is essential for AAV vector transduction in sensory hair cells}, volume = {12}, year = {2025}, }
• (2025). A multifunctional nanodelivery system modified by fusion peptides acts as teriparatide carrier for noise-induced hearing loss therapy. ADVS, 12(29), 2408798. (www)

  @article{ , abstract = {Noise-induced hearing loss (NIHL) is among the most poorly treated diseases due to irreversible damage to hair cells. Reactive oxygen species contribute to NIHL pathogenesis by injuring the inner ear hair cells. Teriparatide (PTH1-34) exerts antioxidant properties in the context of osteoporosis. Thus, in the current study, a multifunctional thermosensitive nanodelivery system is developed, based on the unique anatomical structure of the inner ear, to load and sustain the release of PTH1-34 to alleviate hair cell damage. LR27—a fusion peptide—is assembled from a targeting peptide (A665) and cell-penetrating peptide (Arg8) to target hair cells and increase the round window membrane permeability. In vitro, the antioxidant and anti-apoptotic properties of the nanodelivery system are assessed after treating HEI-OC1 cells and cochlear explants with hydrogen peroxide to simulate the oxidative environment. In vivo, injection of the nanodelivery system into the auditory bulb protects the hearing and hair cells of an NIHL mouse model. These results demonstrate the synergistic effects of multiple peptides in treating NIHL and their potential clinical applications.}, archive = {J_ADVS}, author = {Jiawen Li and Zhuowen Hao and Fangzi Ke and Zhihui Liu and Weilong Wang and Sihui Wen and Fan Wu and Bowen Xu and Miao He and Shengyu Zou and Xiong Chen and Jingfeng Li and Zuhong He}, doi = {10.1002/advs.202408798}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2408798}, shortjournal = {Adv. Sci.}, title = {A multifunctional nanodelivery system modified by fusion peptides acts as teriparatide carrier for noise-induced hearing loss therapy}, volume = {12}, year = {2025}, }
• (2025). Pinoresinol diglucoside attenuates nuclear receptor coactivator 4-mediated ferritinophagy associated with cisplatin-induced hearing loss. ADVS, 12(29), 2408777. (www)

  @article{ , abstract = {Cisplatin can cause irreversible hearing loss. However, effective approaches to its prevention are not established. In this study, the effect of the traditional Chinese medicine monomer pinoresinol diglucoside (PDG) is evaluated on cisplatin-induced ototoxicity and its underlying mechanism of action. PDG significantly increases cell viability and inhibits reactive oxygen species production and ferroptosis in cisplatin-treated House Ear Institute-Organ of Corti 1 cells and basilar membranes. PDG partially restores hearing loss caused by cisplatin. Transcriptome sequencing identifies Suppressor of Cytokine Signaling 1 (SOCS1), which is significantly elevated in the cisplatin-only group but significantly reduced after PDG application. SOCS1 is a ferroptosis-promoting factor, and knocking it down significantly inhibits nuclear receptor coactivator 4 (NCOA4) and inhibits ferritinophagy. Transmission electron microscopy reveals that knocking down SOCS1 reduces the number of autophagic lysosomes induced by cisplatin. Co-immunoprecipitation is performed to confirm the interaction between SOCS1 and NCOA4. Taken together, these results indicate that PDG inhibits NCOA4-mediated ferritinophagy by downregulating SOCS1, which reduces cisplatin-induced ototoxicity. This study provides a new clinical option for the prevention of cisplatin-induced hearing loss.}, archive = {J_ADVS}, author = {Yin Chen and Cheng Cheng and Ao Li and Dengbin Ma and Siyu Li and Handong Wang and Song Gao and Dingding Liu and Panpan Song and Chenjie Yu and Xiaoyun Qian and Guoqiang Wan and Xia Gao}, doi = {10.1002/advs.202408777}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2408777}, shortjournal = {Adv. Sci.}, title = {Pinoresinol diglucoside attenuates nuclear receptor coactivator 4-mediated ferritinophagy associated with cisplatin-induced hearing loss}, volume = {12}, year = {2025}, }
• (2025). RONIN/HCF1-TFEB axis protects against D-galactose-induced cochlear hair cell senescence through autophagy activation. ADVS, 12(29), 2407880. (www)

  @article{ , abstract = {Age-related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy. Despite the improved understanding of these processes, detailed molecular mechanisms underlying cochlear HC senescence remain unclear. Transcription Factor EB (TFEB), a key regulator of genes associated with autophagy and lysosomes, crucially affects aging-related illnesses. However, intricate regulatory networks that influence TFEB activity remain to be thoroughly elucidated. The findings revealed that RONIN (THAP11), through its interaction with host cell factor C1 (HCF1/HCFC1), modulated the transcriptional activity of Tfeb , thus contributing to the mitigation (D-galatactose [D-gal]) senescent HC loss. Specifically, RONIN overexpression improved autophagy levels and lysosomal activity and attenuated changes associated with the senescence of HCs triggered by D-gal. These findings highlight the possibility of using RONIN as a viable therapeutic target to ameliorate presbycusis by enhancing the TFEB function.}, archive = {J_ADVS}, author = {Yongjie Wei and Yuhua Zhang and Wei Cao and Nan Cheng and Yun Xiao and Yongjun Zhu and Yan Xu and Lei Zhang and Lingna Guo and Jun Song and Su-hua Sha and Buwei Shao and Fang Ma and Jingwen Yang and Zheng Ying and Zuhong He and Renjie Chai and Qiaojun Fang and Jianming Yang}, doi = {10.1002/advs.202407880}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2407880}, shortjournal = {Adv. Sci.}, title = {RONIN/HCF1-TFEB axis protects against D-galactose-induced cochlear hair cell senescence through autophagy activation}, volume = {12}, year = {2025}, }
• (2025). Polydopamine nanohydrogel decorated adhesive and responsive hierarchical microcarriers for deafness protection. ADVS, 12(29), 2407637. (www)

  @article{ , abstract = {Cisplatin-induced ototoxicity is attributed to the aberrant accumulation of reactive oxygen species (ROS) within the inner ear. Antioxidants represented by α-lipoic acid (ALA) have been demonstrated to scavenge ROS in the cochlea, while effective delivery of these agents in vivo remains a major challenge. Here, a novel polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for controllable is presented ALA delivery and deafness prevention. As the composite microcarriers exhibit excellent bioadhesion and responsive hierarchical capabilities, this can result in a prolonged retention time in vivo and allow for precise ALA delivery under light stimulation, which significantly enhances the therapeutic efficacy of ALA. Based on these features, both in vitro and in vivo experiments are demonstrated that the composite microcarriers combined with near-infrared light irradiation can effectively attenuate cisplatin-induced ototoxicity. These findings suggest that composite microcarriers are a viable approach for both inner ear medication delivery and the prevention of deafness.}, archive = {J_ADVS}, author = {Hong Chen and Hui Zhang and Jiayi Li and Xianmei Wei and Chenjie Yu and Yuanjin Zhao and Maoli Duan and Xiaoyun Qian and Xia Gao}, doi = {10.1002/advs.202407637}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2407637}, shortjournal = {Adv. Sci.}, title = {Polydopamine nanohydrogel decorated adhesive and responsive hierarchical microcarriers for deafness protection}, volume = {12}, year = {2025}, }
• (2025). Bilirubin targeting WNK1 to alleviate NLRP3-mediated neuroinflammation. ADVS, 12(29), 2407349. (www)

  @article{ , abstract = {Bilirubin, an endogenous metabolite with many significant physiological roles, particularly anti-inflammatory properties, shows great promise as a treatment for inflammatory diseases. However, the binding targets and downstream signaling mechanisms of bilirubin remain unclear. Here, by using quantitative phosphorylation proteomics and several powerful chemical biology techniques such as the Cellular Thermal Shift Assay (CETSA), molecular docking, and MicroScale Thermophoresis (MST), it is identified and confirmed that with-no-lysine (K) kinase 1 (WNK1) is the primary target of bilirubin at physiological concentrations. Bilirubin binds to the kinase domain of WNK1, activating its kinase activity and increasing the intracellular chloride ion concentration via the downstream SPAK/OSR1-KCC2 pathway in neurons. Manipulating endogenous bilirubin levels by deleting Blvra , the bilirubin synthesis enzyme, and Ugt1a1 , its metabolic enzyme, significantly promotes and inhibits the activation of the lipopolysaccharide (LPS)-induced NLRP3 inflammasome, respectively, in mouse hippocampus. Similarly, exogenous bilirubin supplementation suppressed LPS-induced NLRP3 inflammasome activation in mouse hippocampus in a WNK1-dependent manner. Quantitative phosphoproteomic analysis of WNK1 downstream signaling elucidated the broad biological roles of WNK1, notably its function in suppressing inflammation. The findings clarify the direct targets and signaling mechanisms underlying the anti-inflammatory effects of bilirubin and pave the way for exploring its novel functions.}, archive = {J_ADVS}, author = {Linfei Mao and Jiayu Lu and Quanjun Yang and Zhenqi Liu and Cuiping Wu and Bingbing Ke and Kaiyan Su and Haolin Yuan and Yaqi Cui and Yao Wang and Richard Salvi and Guang Yang and Shankai Yin and Feng Liu and Chunyan Li}, doi = {10.1002/advs.202407349}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2407349}, shortjournal = {Adv. Sci.}, title = {Bilirubin targeting WNK1 to alleviate NLRP3-mediated neuroinflammation}, volume = {12}, year = {2025}, }
• (2025). Viral-mediated connexin 26 expression combined with dexamethasone rescues hearing in a conditional gjb2 null mice model. ADVS, 12(29), 2406510. (www)

  @article{ , abstract = {GJB2 encodes connexin 26 (Cx26), the most commonly mutated gene causing hereditary non-syndromic hearing loss. Cx26 is mainly expressed in supporting cells (SCs) and fibrocytes in the mammalian cochlea. Gene therapy is currently considered the most promising strategy for eradicating genetic diseases. However, there have been no significant effects of gene therapy for GJB2 gene mutation-associated deafness because deficiency of Cx26 leads to expanded sensory epithelial damage. In this study, the AAV2.7m8 serotype combined with the gfaABC1D promoter targeted infection of SCs is identified. It is found that Gjb2 gene replacement therapy in wild-type mice results in sensory hair cells (HCs) deficits, excessive inflammatory responses, and hearing loss. This may be one of the key factors contributing to the hardship of GJB2 gene replacement therapy. Dexamethasone (DEX) shows promising results in inhibiting macrophage recruitment, with a protective effect against HC damage. Further, the combination of AAV2.7m8- Gjb2 with DEX shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model. These results indicate that the combination of gene therapy and medication will provide a new strategy for the treatment of hereditary deafness associated with GJB2 defects.}, archive = {J_ADVS}, author = {Xiaohui Wang and Li Zhang and Sen Chen and Le Xie and Yue Qiu and Chenyang Kong and Ge Yin and Weijia Kong and Yu Sun}, doi = {10.1002/advs.202406510}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2406510}, shortjournal = {Adv. Sci.}, title = {Viral-mediated connexin 26 expression combined with dexamethasone rescues hearing in a conditional gjb2 null mice model}, volume = {12}, year = {2025}, }
• (2025). Neural plasticity and hearing-speech development in children with auditory brainstem implants for congenital hearing loss due to severe inner ear malformation. ADVS, 12(29), 2406092. (www)

  @article{ , abstract = {Hearing and speech outcomes of pediatric patients with auditory brainstem implants (ABI) are variable, and the underlying developmental mechanism remains unexplored. This study aims to evaluate the effectiveness of ABI in pediatric patients with congenital non-tumor hearing loss and elucidate the role of cortical plasticity in hearing and speech development. A prospective cohort study is conducted involving 112 consecutive pediatric patients who received ABI at a tertiary university-based referral center from January 2019 to October 2023. The mean age at the time of surgery and postoperative follow-up are 3.4±1.9 years and 25.7±11.7 months (3–48 months), respectively. The average percentage of elicited electrodes (eABR%) during the operation is 72.73±17.99%. Post-activation, hearing and speech outcomes improved steadily. Younger age at implantation (<3 years), less severe inner-ear malformation, and higher intraoperative eABR% (≥60%) are significantly associated with better hearing and speech outcomes. Mismatch negativity (MMN) responses are evoked in all children aged 12–18 months. Cortical functional connectivity developed after activation, particularly within the bilateral temporal/frontal lobes. Several factors contribute to hearing and speech development in children with ABI, and cortical plasticity plays a pivotal role. MMN amplitude and brain functional connectivity may serve as cortical indices for predicting long-term outcomes.}, archive = {J_ADVS}, author = {Yu Zhang and Yongchuan Chai and Yiwen Zhang and Huan Jia and Zhaoyan Wang and Zhihua Zhang and Zhili Wang and Jie Chen and Xue Wang and Yun Li and Ying Chen and Hao Wu}, doi = {10.1002/advs.202406092}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2406092}, shortjournal = {Adv. Sci.}, title = {Neural plasticity and hearing-speech development in children with auditory brainstem implants for congenital hearing loss due to severe inner ear malformation}, volume = {12}, year = {2025}, }
• (2025). Advances in microfluidic cochlea-on-A-chip. ADVS, 12(29), 2406077. (www)

  @article{ , abstract = {The current understanding of the human auditory system has been primarily based on studies using animal and cellular models. Organoids have been used to simulate cochlear structures and replicate cochlear functions. However, the physical and chemical cues required to control the development of cochlear organoids accurately remain poorly understood, limiting research advances on cochlea-on-a-chip systems. Consequently, the development of cochlea-on-a-chip platforms that provide reliable preclinical testing grounds for studying inner ear developmental mechanisms and screening-related therapeutic drugs has become a key focus for future cochlea-on-a-chip technologies. In this review, the recent advancements in cochlea-on-a-chip technology are summarized. First, an overview of cochlear anatomy and physiology is provided. Next, the latest breakthroughs are discussed in the 3D cultivation of inner ear organoids and explore the progress in microfluidic technologies for constructing cochlea-on-a-chip systems. Finally, perspectives are presented on the current challenges and future directions for developing cochlea-on-a-chip technology.}, archive = {J_ADVS}, author = {Tian Shen and Shanying Han and Weiwei He and Wen Yang and Xinghua Tang and Xiaolong Zhao and Xinghong Liu and Zhenhua Shao and Lin Cheng and Yu Zhao and Jiangang Fan}, doi = {10.1002/advs.202406077}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2406077}, shortjournal = {Adv. Sci.}, title = {Advances in microfluidic cochlea-on-A-chip}, volume = {12}, year = {2025}, }
• (2025). Lycium barbarum glycopeptide alleviates neomycin-induced ototoxicity by inhibiting tryptophan hydroxylase-mediated serotonin biosynthesis. ADVS, 12(29), 2405850. (www)

  @article{ , abstract = {Aminoglycoside antibiotic-induced sensorineural hearing loss (SNHL) is a common sensory disorder that requires the development of prophylactic and therapeutic interventions. Lycium barbarum glycopeptide (LBGP) is a peptidoglycan isolated and purified from Lycium barbarum polysaccharides that exhibit significant anti-inflammatory, antioxidant, and neuroprotective effects, but the role of LBGP in aminoglycoside-induced SNHL has not been well investigated. Here it is shown that LBGP can protect against neomycin-induced hearing impairment and alleviate oxidative stress in a neomycin-induced SNHL mouse model. Moreover, it is further found that inhibition of tryptophan hydroxylase (Tph)-mediated serotonin (5-HT) biosynthesis plays a key role in the mechanism of action of LBGP in treating neomycin-induced hearing loss. Systemic delivery of 5-HT increased neomycin-induced apoptosis of cochlear hair cells and spiral ganglion neurons, and pharmacological Tph2 inhibition with P-chlorophenylalanine or Tph2 knock down by AAV-ie- Tph2 effectively attenuated neomycin-induced hearing dysfunction. Collectively, these results provide a promising strategy for the prevention of SNHL by using natural plant extract which is more available and exhibits lower side effects compared with other otoprotective drugs, and identify Tph2 as a potential pharmacological target for the treatment of aminoglycoside-induced ototoxicity.}, archive = {J_ADVS}, author = {Yunhao Wu and Li Zhang and Shengda Cao and Jingwen Zhang and Cheng Li and Yunlong Shan and Qiuping Liu and Zhexiong Yu and Qiaojun Fang and Yuhua Zhang and Xiaolong Fu and Kwok-Fai So and Renjie Chai}, doi = {10.1002/advs.202405850}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {2405850}, shortjournal = {Adv. Sci.}, title = {Lycium barbarum glycopeptide alleviates neomycin-induced ototoxicity by inhibiting tryptophan hydroxylase-mediated serotonin biosynthesis}, volume = {12}, year = {2025}, }
• (2025). Responsive ROS-augmented prodrug hybridization nanoassemblies for multidimensionally synergitic treatment of hepatocellular carcinoma in cascade assaults (Adv. sci. 29/2025). ADVS, 12(29), 71032. (www)

  @article{ , archive = {J_ADVS}, author = {Yingjie Zeng and Yuening Cao and Senmiao Ren and Chaozheng Zhang and Jianan Liu and Ke Liu and Yan Wang and Hongyu Chen and Fengjiao Zhou and Xiuli Yang and Xian Ge and Tingting Zhang and Tianbao Wang and Yao He and Defang Li and Chuantao Zhang and Jun Lu}, doi = {10.1002/advs.71032}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71032}, shortjournal = {Adv. Sci.}, title = {Responsive ROS-augmented prodrug hybridization nanoassemblies for multidimensionally synergitic treatment of hepatocellular carcinoma in cascade assaults (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). Fast pH-driven solubilization method of realgar (As4S4) to reduce the toxicity of arsenic [As(III)] for medicinal purposes (Adv. sci. 29/2025). ADVS, 12(29), 71030. (www)

  @article{ , archive = {J_ADVS}, author = {Bojana Lucic and Douglas Santana Franciscato and Helton Pereira Nogueira and Lara Gallucci and Alceu Totti Silveira Junior and Asmaa Mohamed Ismail and Millie Robinson and Teresa Dallinger and Claudia Gutfleisch and Jochen Kurz and Maytê Toledo and Jessica Dias da Silva Ferraz and Mohammad Tarek and Danilo Dias and Ricardo Sobhie Diaz and Mahmoud ElHefnawi and Mattia Forcato and Hugo P Monteiro and Marina Lusic and Iart Luca Shytaj and Andrea Savarino}, doi = {10.1002/advs.71030}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71030}, shortjournal = {Adv. Sci.}, title = {Fast pH-driven solubilization method of realgar (As4S4) to reduce the toxicity of arsenic [As(III)] for medicinal purposes (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). Macroscopic structural transition of nickel dithiolate capsule with uniaxial magnetic anisotropy in water (Adv. sci. 29/2025). ADVS, 12(29), 71029. (www)

  @article{ , archive = {J_ADVS}, author = {Tomoko Fujino and Mafumi Hishida and Masatoshi Ito and Toshikazu Nakamura and Mizue Asada and Naoya Kurahashi and Hisao Kiuchi and Yoshihisa Harada and Koji Harano and Rie Makiura and Kanokwan Jumtee Takeno and So Yokomori and Hiroshi Oike and Hatsumi Mori}, doi = {10.1002/advs.71029}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71029}, shortjournal = {Adv. Sci.}, title = {Macroscopic structural transition of nickel dithiolate capsule with uniaxial magnetic anisotropy in water (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). Large area high-performance thin film solid oxide fuel cell with nanoscale anode functional layer by scalable reactive sputtering (Adv. sci. 29/2025). ADVS, 12(29), 71028. (www)

  @article{ , archive = {J_ADVS}, author = {Kyoungjae Ju and Seongkook Oh and Jong Hyuk Lee and Hyong June Kim and Hyunmin Kim and Sung Eun Jo and Juhwan Lee and Byung Chan Yang and Jisung Yoon and Dong Won Shin and Wanwoo Park and Ji-Won Son and Young-Beom Kim and Sungeun Yang and Jihwan An}, doi = {10.1002/advs.71028}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71028}, shortjournal = {Adv. Sci.}, title = {Large area high-performance thin film solid oxide fuel cell with nanoscale anode functional layer by scalable reactive sputtering (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). Reinforcing stromal cell spheroid through red-light preconditioning for advanced vascularization (Adv. sci. 29/2025). ADVS, 12(29), 71027. (www)

  @article{ , archive = {J_ADVS}, author = {Yu-Jin Kim and Hyeok Kim and Dong-Hyun Lee and Yeong Hwan Kim and Jae-Hyun Park and Woo-Sup Sim and Jin-Ju Kim and Kiwon Ban and Soong Ho Um and Hyun Ji Park and Michael E. Davis and Hun-Jun Park and Suk Ho Bhang}, doi = {10.1002/advs.71027}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71027}, shortjournal = {Adv. Sci.}, title = {Reinforcing stromal cell spheroid through red-light preconditioning for advanced vascularization (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). A bead-based quantum dot immunoassay integrated with multi-module microfluidics enables real-time multiplexed detection of blood insulin and glucagon (Adv. sci. 29/2025). ADVS, 12(29), 71026. (www)

  @article{ , archive = {J_ADVS}, author = {Hesam Abouali and Sanjana Srikant and Md Fahim Al Fattah and Nicole G. Barra and Darryl Chan and Dayan Ban and Jonathan D. Schertzer and Mahla Poudineh}, doi = {10.1002/advs.71026}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71026}, shortjournal = {Adv. Sci.}, title = {A bead-based quantum dot immunoassay integrated with multi-module microfluidics enables real-time multiplexed detection of blood insulin and glucagon (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). Plasmonic molecular entrapment for label-free methylated DNA detection and machine-learning assisted quantification (Adv. sci. 29/2025). ADVS, 12(29), 71025. (www)

  @article{ , archive = {J_ADVS}, author = {Muhammad Shalahuddin Al Ja'farawy and Vo Thi Nhat Linh and Chaewon Mun and Jun-Yeong Yang and Jun Young Kim and Rowoon Park and Sung-Gyu Park and Dong-Ho Kim and Min-Young Lee and Ho Sang Jung}, doi = {10.1002/advs.71025}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71025}, shortjournal = {Adv. Sci.}, title = {Plasmonic molecular entrapment for label-free methylated DNA detection and machine-learning assisted quantification (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). Simultaneous multi-resonant thermally activated delayed fluorescence and room temperature phosphorescence from biluminescent nitrogen-containing indolocarbazoles (Adv. sci. 29/2025). ADVS, 12(29), 71024. (www)

  @article{ , archive = {J_ADVS}, author = {Oliver S. Lee and Aidan P. McKay and David B. Cordes and Stuart L. Warriner and Malte C. Gather and Eli Zysman-Colman}, doi = {10.1002/advs.71024}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71024}, shortjournal = {Adv. Sci.}, title = {Simultaneous multi-resonant thermally activated delayed fluorescence and room temperature phosphorescence from biluminescent nitrogen-containing indolocarbazoles (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). Eosinophils-induced lumican secretion by synovial fibroblasts alleviates cartilage degradation via the TGF-β pathway mediated by anxa1 binding (Adv. sci. 29/2025). ADVS, 12(29), 71023. (www)

  @article{ , archive = {J_ADVS}, author = {Wenqian Chen and Yuwei Zhou and Wenxiu Yuan and Yanjing Ou and Hanyu Lin and Kaixun He and Xueshen Qian and Huachen Chen and Chengchaozi Wang and Jie Lu and Weiping Chen and Dexiong Li and Jiang Chen}, doi = {10.1002/advs.71023}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {71023}, shortjournal = {Adv. Sci.}, title = {Eosinophils-induced lumican secretion by synovial fibroblasts alleviates cartilage degradation via the TGF-β pathway mediated by anxa1 binding (Adv. sci. 29/2025)}, volume = {12}, year = {2025}, }
• (2025). Multi-mechanical regulation of 3D printed triply periodic hyperbolic surfaces via fourier synthesis-based free modeling. ADVS, 12(29), 70028. (www)

  @article{ , abstract = {Triply periodic hyperbolic surfaces (TPHSs) have attracted significant attention due to their exceptional lightweight and mechanical properties, which surpass those of other lattice structures. These advantages are primarily attributed to their unique periodic geometries and saddle-shaped surface configurations. However, current structural design methods mainly rely on narrowband forward or multivariable inverse design strategies, which greatly limits the structural diversity and tunability of TPHSs, thereby hindering their further advancements in engineering applications. Herein, a hierarchical design method inspired by crystallographic Fourier synthesis is proposed, enabling the construction of arbitrary complex structures and the regulation of mechanical properties in multiple ways. By utilizing this approach, any structural types of TPHSs, including the most appealing primitive, gyroid, diamond-like surfaces and their structural variants, are additively manufactured. This method enables precise manipulation of fine structural features to optimize 3D stress fields, significantly enhancing overall stiffness and strength. Moreover, this method facilitates the design of unbalanced TPHSs with rod-like characteristics, enabling structural assembly through mortise-tenon joints, which greatly expands the construction methodologies for such structures. This research substantially extends the design space of TPHS-based structures and paves the way for their widespread application in advanced engineering contexts.}, archive = {J_ADVS}, author = {Yanhong Zhang and Junming Zhang and Zhimei Zhou and Yan Li and Shunai Che and Weidong Yang and Lu Han}, doi = {10.1002/advs.202503694}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {70028}, shortjournal = {Adv. Sci.}, title = {Multi-mechanical regulation of 3D printed triply periodic hyperbolic surfaces via fourier synthesis-based free modeling}, volume = {12}, year = {2025}, }
• (2025). Organocatalytic C─O bond cleavage and asymmetric transformations via [1,3]-sigmatropic rearrangement. ADVS, 12(29), 70006. (www)

  @article{ , abstract = {Here, an organocatalytic asymmetric [1,3]-sigmatropic rearrangement process for aryl ether insertion through C─O bond cleavage and downstream transformation is reported, enabling the practical and atom-economic synthesis of diverse valuable chiral benzofuran derivatives bearing a quaternary carbon stereocenter. The reaction shows a wide substrate scope, yielding moderate to good products with excellent enantioselectivity and diastereoselectivity (up to >99% ee and >99:1 d.r.). Initial biological activity tests suggest that the resulting enantioenriched benzofuran products hold potential as anticancer agents.}, archive = {J_ADVS}, author = {Lei Peng and Yu Chang and Liangchen Yin and Jinbang Zhang and Xuli Feng and Pengfei Wang and Wenling Qin and Hailong Yan}, doi = {10.1002/advs.202504718}, journal = {Advanced Science}, month = {8}, number = {29}, pages = {70006}, shortjournal = {Adv. Sci.}, title = {Organocatalytic C─O bond cleavage and asymmetric transformations via [1,3]-sigmatropic rearrangement}, volume = {12}, year = {2025}, }
• (2025). Enhancing specificity, precision, accessibility, flexibility, and safety to overcome traditional CRISPR/Cas editing challenges and shape future innovations. ADVS, 12(28), e2416331. (www)

  @article{ , abstract = {Derived from the bacterial immune system, CRISPR/Cas9 induces DSBs at specific DNA sequences, which are repaired by the cell's endogenous mechanisms, leading to gene insertions, deletions, or substitutions. Despite its transformative potential, several challenges remain in optimizing of CRISPR/Cas systems, including off-target effects, delivery methods, PAM restrictions, and the limitations of traditional editing approaches. This review focuses on the interplay between these challenges and their contributions to gene editing precision, specificity, accessibility, flexibility, and safety. How reducing off-target effects enhances specificity and safety is explored, while discussing the role of HDR-based editing in achieving precise gene modifications, alongside alternative methods such as base editing and prime editing. Improved delivery mechanisms are examined for their impact on accessibility and efficiency, while the reduction of PAM restrictions is highlighted for its contributions to flexibility. Lastly, emerging cleavage-free editing technologies are evaluated as they relate to safety and accessibility. This focused review aims to clarify the connections among these aspects and outline future research directions for advancing CRISPR-based applications.}, archive = {J_ADVS}, author = {Muna Alariqi and Mohamed Ramadan and Lu Yu and Fengjiao Hui and Amjad Hussain and Xiaofeng Zhou and Yu Yu and Xianlong Zhang and Shuangxia Jin}, doi = {10.1002/advs.202416331}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {e2416331}, shortjournal = {Adv. Sci.}, title = {Enhancing specificity, precision, accessibility, flexibility, and safety to overcome traditional CRISPR/Cas editing challenges and shape future innovations}, volume = {12}, year = {2025}, }
• (2025). Genetics-based targeting strategies for precise neuromodulation. ADVS, 12(28), e13817. (www)

  @article{ , abstract = {Genetics-based neuromodulation schemes are capable of selectively manipulating the activity of defined cell populations with high temporal–spatial resolution, providing unprecedented opportunities for probing cellular biological mechanisms, resolving neuronal projection pathways, mapping neural profiles, and precisely treating neurological and psychiatric disorders. Multimodal implementation schemes, which involve the use of exogenous stimuli such as light, heat, mechanical force, chemicals, electricity, and magnetic stimulation in combination with specific genetically engineered effectors, greatly expand their application space and scenarios. In particular, advanced wireless stimulation schemes have enabled low-invasive targeted neuromodulation through local delivery of navigable micro- and nanosized stimulators. In this review, the fundamental principles and implementation protocols of genetics-based precision neuromodulation are first introduced.The implementation schemes are systematically summarized, including optical, thermal, force, chemical, electrical, and magnetic stimulation, with an emphasis on those wireless and low-invasive strategies. Representative studies are dissected and analyzed for their advantages and disadvantages. Finally, the significance of genetics-based precision neuromodulation is emphasized and the open challenges and future perspectives are concluded.}, archive = {J_ADVS}, author = {Yuyuan He and Zhidong Wei and Jianda Xu and Fei Jin and Tong Li and Lili Qian and Juan Ma and Weiying Zheng and Negar Javanmardi and Ting Wang and Kangjian Sun and Zhang-Qi Feng}, doi = {10.1002/advs.202413817}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {e13817}, shortjournal = {Adv. Sci.}, title = {Genetics-based targeting strategies for precise neuromodulation}, volume = {12}, year = {2025}, }
• (2025). Harnessing dynamic electrostatic fields for energy generation with diode cells. ADVS, 12(28), e05476. (www)

  @article{ , abstract = {Harvesting energy from distributed mechanical motions has garnered significance in future power sources for small electronics and sensors. Although technologies like triboelectric nanogenerators have shown promising results, their efficacy hinges on the alignment of motion vectors and device architectures. Here, an approach employing stationary diode cells (DiCes) to generate electricity is presented. This approach leverages dynamically changing electrostatic fields to induce potential differences across diode junctions via electrostatic induction, which is verified theoretically and experimentally. DiCes constructed with multiple diodes can directly output DC voltage and current. A 0.02 m 2 sized DiCe contains 360 diodes can supply a DC voltage and current of maximum 490 V and 1.08 mA, respectively, which equals a DC power density of 26.5 W·m −2 . Capable of functioning in both contact and non-contact modes, DiCes offer versatile applications, from wirelessly powering implanted medical devices to harvesting energy from vehicles and roads.}, archive = {J_ADVS}, author = {Renyun Zhang and Magnus Hummelgård and Ye Xu and Martin Olsen and Jonas Örtegren and Göran Thungström and Henrik Andersson and Zhong Lin Wang}, doi = {10.1002/advs.202505476}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {e05476}, shortjournal = {Adv. Sci.}, title = {Harnessing dynamic electrostatic fields for energy generation with diode cells}, volume = {12}, year = {2025}, }
• (2025). A feedback loop between fatty acid metabolism and epigenetics in clear cell renal carcinoma. ADVS, 12(28), e04532. (www)

  @article{ , abstract = {Lipid storage and epigenetic dysregulation are key features for clear cell renal carcinoma (ccRCC). However, the interplay between fatty acid metabolism and epigenetics in ccRCC remains to be further demonstrated. Here, the landscape of active enhancers is profiled in paired ccRCC samples and identifies 10171 gain variant enhancer loci (VELs) in the tumor tissues. Experimental validation reveals the enhancers targeting FABP5 , FABP6 , LPCAT1 , MET , SEMA5B , SH3GL1 , SNX33 , and RHBDF2 are oncogenic. Further studies in organoids and animal models prove FABP5 as an oncogene. HIF-2α and ZNF692 transcription factors regulate FABP5 expression through directly binding to its promoter and enhancer. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity in ccRCC cells. Thus, the study has identified potential targets for drug design and diagnosis and discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC.}, archive = {J_ADVS}, author = {Zhou Ye and Qi-Xin Hu and Ming-Liang Wei and Ji-Dong Chen and Jia Shi and Ning-Rong Yang and Lu Jiang and Jian Chen and Zhi-Yuan Chen and Wei-Min Yu and Yu Xiao and Kai-Yu Qian and Zilin Xu and Zhong Wang and Wen-Lu Qi and Xin-Yi Xiao and Yu-Yu Duan and Yong Xiao and Lian-Yun Li and Lin-Gao Ju and Ming-Kai Chen and Min Wu}, doi = {10.1002/advs.202504532}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {e04532}, shortjournal = {Adv. Sci.}, title = {A feedback loop between fatty acid metabolism and epigenetics in clear cell renal carcinoma}, volume = {12}, year = {2025}, }
• (2025). Blood biomarker-based predictive indicator for liver metastasis in alpha-fetoprotein-producing gastric cancer and multi-omics tumor microenvironment insights. ADVS, 12(28), e03499. (www)

  @article{ , abstract = {Alpha-fetoprotein-producing gastric cancer (AFPGC) is a rare but highly aggressive subtype of gastric cancer. Patients with AFPGC are at high risk of liver metastasis, and the tumor microenvironment (TME) is complex. A multicenter retrospective study is conducted from January 2011 to December 2021 and included 317 AFPGC patients. Using a multivariable logistic regression model, a nomogram for predicting liver metastasis is built. By combining AFP and the neutrophil–lymphocyte ratio (NLR), we developed a novel and easily applicable predictive indicator, termed ANLiM score, for liver metastasis in AFPGC. An integrated multi-omics analysis, including whole-exome sequencing and proteomic analysis, is conducted and revealed an immunosuppressive TME in AFPGC with liver metastasis. Single-cell RNA sequencing and multiplex immunofluorescence identified the potential roles of tumor-associated neutrophils and tertiary lymphoid structures in shaping the immune microenvironment. These findings are validated in a real-world cohort receiving anti-programmed cell death 1 (anti-PD-1) therapy, which showed concordant effectiveness. In addition, the ANLiM score is also identified as a promising biomarker for predicting immunotherapy efficacy. Overall, a blood biomarker-based predictive indicator is developed for liver metastasis and immunotherapy response in AFPGC. The findings on immune microenvironmental alterations for AFPGC with liver metastasis provide new insights for optimizing immunotherapy strategies.}, archive = {J_ADVS}, author = {Yongfeng Ding and Yiran Chen and Jing Zhang and Qingrui Wang and Songting Zhu and Junjie Jiang and Chao He and Jincheng Wang and Laizhen Tou and Jingwei Zheng and Bicheng Chen and Sizhe Hu and Xiongfei Yu and Haohao Wang and Yimin Lu and Mei Kong and Yanyan Chen and Haiyong Wang and Haibin Zhang and Hongxia Xu and Fei Teng and Xian Shen and Nong Xu and Jian Ruan and Zhan Zhou and Jun Lu and Lisong Teng}, doi = {10.1002/advs.202503499}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {e03499}, shortjournal = {Adv. Sci.}, title = {Blood biomarker-based predictive indicator for liver metastasis in alpha-fetoprotein-producing gastric cancer and multi-omics tumor microenvironment insights}, volume = {12}, year = {2025}, }
• (2025). Protected chaos in a topological lattice. ADVS, 12(28), e03216. (www)

  @article{ , abstract = {The erratic nature of chaotic behavior is thought to erode the stability of periodic behavior, including topological oscillations. However, it is discovered that in the presence of chaos, non-trivial topology not only endures but also provides robust protection to chaotic dynamics within a topological lattice hosting non-linear oscillators. Despite the difficulty in defining topological invariants in non-linear settings, non-trivial topological robustness still persists in the parametric state of chaotic boundary oscillations. This interplay between chaos and topology is demonstrated by incorporating chaotic Chua's circuits into a topological Su-Schrieffer-Heeger (SSH) circuit. By extrapolating from the linear limit to deep into the non-linear regime, it is found that distinctive correlations in the bulk and edge scroll dynamics effectively capture the topological origin of the protected chaos. The findings suggest that topologically protected chaos can be robustly achieved across a broad spectrum of periodically driven systems, thereby offering new avenues for the design of resilient and adaptable non-linear networks.}, archive = {J_ADVS}, author = {Haydar Sahin and Hakan Akgün and Zhuo Bin Siu and S. M. Rafi-Ul-Islam and Jian Feng Kong and Mansoor B. A. Jalil and Ching Hua Lee}, doi = {10.1002/advs.202503216}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {e03216}, shortjournal = {Adv. Sci.}, title = {Protected chaos in a topological lattice}, volume = {12}, year = {2025}, }
• (2025). Natural Toolbox–Chemical engineering aspect and high-value applications of janus cellulose nanomaterials. ADVS, 12(28), e00820. (www)

  @article{ , abstract = {Nanotechnology has emerged as a transformative force, enabling the manipulation and engineering of materials at the nanoscale level, which has led to the discovery and development of novel materials with unique properties and functionalities. Janus cellulose nanomaterials, a product of nanotechnology, have attracted significant attention. This article aims to address the current lack of fundamental mechanistic understanding in Janus cellulose by investigating the intrinsic relationship between structural design and functional performance. Specifically, it begins by elucidating the construction principles of Janus cellulose nanomaterials, with a particular focus on how their asymmetric architectures impart anisotropic physicochemical properties, such as interfacial tension modulation, directional interactions, and selective transport. By integrating multiscale modeling approaches—including molecular dynamics simulations and density functional theory calculations—the underlying interfacial behaviors and assembly pathways are revealed, providing theoretical insight into their conformational stability and dynamic response mechanisms. It also explores how surface functionalization and selective chemical modification strategies can be leveraged to finetune hydrophilicity/hydrophobicity balance and interfacial activity, thereby enabling precise control over Janus cellulose interface configuration and functional attributes. On this basis, it further examines non-covalent driving forces—including electrostatic interactions, van der Waals forces, and hydrogen bonding—within the self-assembly process, and systematically maps the relationship between assembly conditions and structural evolution. This work establishes a comprehensive structure–driving force–assembly process–property framework, offering theoretical support and design guidance for the development of high-performance Janus cellulose nanomaterials in advanced applications such as flexible electronics, smart sensing systems, controlled drug delivery, and energy conversion and storage.}, archive = {J_ADVS}, author = {Yu Zhao and Shengjie Wang and Zongchen Wei and Shiming Qiu and Guofu Zhou and Jr-Hau He and Xuezhu Xu}, doi = {10.1002/advs.202500820}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {e00820}, shortjournal = {Adv. Sci.}, title = {Natural Toolbox–Chemical engineering aspect and high-value applications of janus cellulose nanomaterials}, volume = {12}, year = {2025}, }
• (2025). The state of high-resolution imaging of the human inner ear: A look into the black box. ADVS, 12(28), e00556. (www)

  @article{ , abstract = {Unlike most medical fields, otology has not benefited from the transformative impact of high-resolution, cellular-level imaging. The sensorineural cells required for human hearing—located within the cochlea—are just 10–50 µm, placing them outside the resolution of magnetic resonance imaging, computed tomography, and positron emission tomography. These cells are highly mechano- and chemo-sensitive, and their death or dysfunction underlie the vast majority of hearing loss. Further, the cochlea is only 4–7 mm in diameter, has complex anatomy, and is deeply embedded in bone. Cochlear blood flow is partially separated by a blood barrier, limiting access to radiotracers or fluorophores. These and other features have left the human cochlea as a “black box” that cannot be assessed with high precision in vivo, limiting the development of novel hearing loss therapies. The benefits and drawbacks of existing medical imaging techniques used to diagnose disorders of the human inner ear are discussed, as well as those of emerging technologies that may help overcome challenges to access, resolution, and functional detail. A comprehensive and up-to-date discussion is provided on research efforts to improve and adapt current clinical imaging methods and introduce recent innovations that have shown exciting promise for deriving both structural and metabolic information from cochlear cells.}, archive = {J_ADVS}, author = {Shelley Batts and Nancy Pham and Guillermo Tearney and Konstantina M. Stankovic}, doi = {10.1002/advs.202500556}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {e00556}, shortjournal = {Adv. Sci.}, title = {The state of high-resolution imaging of the human inner ear: A look into the black box}, volume = {12}, year = {2025}, }
• (2025). Photo-rechargeable organic supercapacitor via light-activated electrolytes (Adv. sci. 28/2025). ADVS, 12(28), 2570225. (www)

  @article{ , archive = {J_ADVS}, author = {Shubhra Kanti Bhaumik and Sudipta Biswas and Nitzan Shauloff and Ahiud Morag and Raz Jelinek}, doi = {10.1002/advs.202570225}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570225}, shortjournal = {Adv. Sci.}, title = {Photo-rechargeable organic supercapacitor via light-activated electrolytes (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). M2 macrophage-derived extracellular vesicles reprogram immature neutrophils into anxa1hi neutrophils to enhance inflamed bone regeneration (Adv. sci. 28/2025). ADVS, 12(28), 2570224. (www)

  @article{ , archive = {J_ADVS}, author = {Yufei Yao and Yijia Yin and Fangyuan Shuai and Waishan Lam and Tao Zhou and Yaxin Xie and Xuesong He and Xianglong Han}, doi = {10.1002/advs.202570224}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570224}, shortjournal = {Adv. Sci.}, title = {M2 macrophage-derived extracellular vesicles reprogram immature neutrophils into anxa1hi neutrophils to enhance inflamed bone regeneration (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). High-throughput tiling of essential mRNAs increases potency of antisense antibiotics (Adv. sci. 28/2025). ADVS, 12(28), 2570223. (www)

  @article{ , archive = {J_ADVS}, author = {Giorgia Danti and Linda Popella and Jörg Vogel and Hans M. Maric}, doi = {10.1002/advs.202570223}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570223}, shortjournal = {Adv. Sci.}, title = {High-throughput tiling of essential mRNAs increases potency of antisense antibiotics (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). Potential-driven dynamic spring-effect of Pd─Cu dual-atoms empowered stability and activity for electrocatalytic reduction (Adv. sci. 28/2025). ADVS, 12(28), 2570222. (www)

  @article{ , archive = {J_ADVS}, author = {Pei-Hua Li and Yuan-Fan Yang and Zong-Yin Song and Bo Liang and Yong-Huan Zhao and Xin Cai and Zi-Hao Liu and Jing-Yi Lin and Meng Yang and Xiangyu Xiao and Jing Zhang and Wen-Qing Liu and Xing-Jiu Huang}, doi = {10.1002/advs.202570222}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570222}, shortjournal = {Adv. Sci.}, title = {Potential-driven dynamic spring-effect of Pd─Cu dual-atoms empowered stability and activity for electrocatalytic reduction (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). Synchrotron radiation-based tomography of an entire mouse brain with sub-micron voxels: Augmenting interactive brain atlases with terabyte data (Adv. sci. 28/2025). ADVS, 12(28), 2570221. (www)

  @article{ , archive = {J_ADVS}, author = {Mattia Humbel and Christine Tanner and Marta Girona Alarcón and Georg Schulz and Timm Weitkamp and Mario Scheel and Vartan Kurtcuoglu and Bert Müller and Griffin Rodgers}, doi = {10.1002/advs.202570221}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570221}, shortjournal = {Adv. Sci.}, title = {Synchrotron radiation-based tomography of an entire mouse brain with sub-micron voxels: Augmenting interactive brain atlases with terabyte data (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). 36-channel spin and wavelength co-multiplexed metasurface holography by phase-gradient inverse design (Adv. sci. 28/2025). ADVS, 12(28), 2570219. (www)

  @article{ , archive = {J_ADVS}, author = {Cherry Park and Youngsun Jeon and Junsuk Rho}, doi = {10.1002/advs.202570219}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570219}, shortjournal = {Adv. Sci.}, title = {36-channel spin and wavelength co-multiplexed metasurface holography by phase-gradient inverse design (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). Identification and drug screening of single cells from human tumors on semiconductor chip for cancer precision medicine (Adv. sci. 28/2025). ADVS, 12(28), 2570218. (www)

  @article{ , archive = {J_ADVS}, author = {Wenhao Hui and Ka-Meng Lei and Yingying Liu and Xinru Huang and Yunlong Zhong and Xiaojun Chen and Mingji Wei and Jie Yan and Ren Shen and Pui-In Mak and Rui P. Martins and Shuhong Yi and Ping Wang and Yanwei Jia}, doi = {10.1002/advs.202570218}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570218}, shortjournal = {Adv. Sci.}, title = {Identification and drug screening of single cells from human tumors on semiconductor chip for cancer precision medicine (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). An enhanced “Trapping–Conversion” function enables ultrastable potassium ion storage (Adv. sci. 28/2025). ADVS, 12(28), 2570217. (www)

  @article{ , archive = {J_ADVS}, author = {Zhongquan Wang and Bangjun Wu and Zhenping Qiu and Qingguang Zeng and Aruuhan Bayaguud and Huirong Wang and Zheng Liu and Yiju Li and Yelong Zhang}, doi = {10.1002/advs.202570217}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570217}, shortjournal = {Adv. Sci.}, title = {An enhanced “Trapping–Conversion” function enables ultrastable potassium ion storage (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). Hybrid solar spectral-splitting photovoltaic-thermal hydrogen production systems (Adv. sci. 28/2025). ADVS, 12(28), 2570216. (www)

  @article{ , archive = {J_ADVS}, author = {Yu Tian and Pooria Hadikhani and Nada Alati and Bryce S. Richards and Gan Huang}, doi = {10.1002/advs.202570216}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2570216}, shortjournal = {Adv. Sci.}, title = {Hybrid solar spectral-splitting photovoltaic-thermal hydrogen production systems (Adv. sci. 28/2025)}, volume = {12}, year = {2025}, }
• (2025). Development of a DNA aptamer-based approach to noninvasively image CAR-T cells in vivo and traceless enrichment in vitro. ADVS, 12(28), 2506746. (www)

  @article{ , abstract = {Chimeric antigen receptor (CAR) T cells offered a potential cure for malignancies, however, their outcomes and dynamics across different anatomical sites remained inadequately characterized. Monitoring the bio-distribution and tumor-homing of CAR-T cells in vivo is crucial, as it provides patient-specific data that might inform on treatment success, potential failure, and off-target toxicities. Herein, an Aptamer A3 by Cell-SELEX (systematic evolution of ligands by exponential enrichment) is generated, which can bind with CAR-T cells with nanomolar affinity. After CAR-T cells are injected into Nalm6 xenograft tumor model mice through tail vein, Cy5-labeled A3 is injected into mice for fluorescence time-delay imaging in vivo. The fluorescence signal produced by the Cy5-labeled A3 is accumulated in the tumor area and reached its maximum at day 14. Moreover, A3 could enrich CAR-T cells in mixed cell populations in a traceless way. A3 is screened for CAR-T cells imaging and CAR-T cells enrichment, which may provide assistance for the evaluation of CAR-T cells efficacy and the manufacture of CAR-T cells. Overall, this research shows that A3 enabled repeated, sensitive, and specific assessment of the infused CAR-T cells in vivo. The screened aptamer will have broad applications for tracking CAR-T cells in patients, providing insights into treatment success, potential failure, and off-target toxicities.}, archive = {J_ADVS}, author = {Minghui Chen and Pengzhao Chang and Zhen Zhang and Dan Liu and Rui Hou and Ming Shi and Jingjing Li and Kai Xu and Junnian Zheng}, doi = {10.1002/advs.202506746}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2506746}, shortjournal = {Adv. Sci.}, title = {Development of a DNA aptamer-based approach to noninvasively image CAR-T cells in vivo and traceless enrichment in vitro}, volume = {12}, year = {2025}, }
• (2025). PRMT3-mediated H4R3me2a promotes primary age-related tauopathy by driving tau hyperphosphorylation in neuron. ADVS, 12(28), 2506044. (www)

  @article{ , abstract = {Primary age-related tauopathy (PART) and Alzheimer's disease (AD) both exhibit 3R/4R hyperphosphorylated tau-positive neurofibrillary tangles (NFTs) within the hippocampal–entorhinal system. Notably, PART patients show a higher degree of tau hyperphosphorylation in the entorhinal cortex (EC) than AD, yet the molecular mechanisms driving Aβ-independent tau hyperphosphorylation in PART remain poorly understood. Herein, through transcriptomic profiling of postmortem EC tissues and in vitro and in vivo functional validation, the present study identifies protein arginine methyltransferase 3 (PRMT3) as a critical driver of tau hyperphosphorylation. Mechanistically, PRMT3-mediated tau hyperphosphorylation is dependent on asymmetric dimethylation of histone H4 at arginine 3 (H4R3me2a), which upregulates miR-448. Elevated miR-448 specifically targets and suppresses IGF1R, leading to downstream GSK3β activation and subsequent tau hyperphosphorylation through PI3K/AKT/GSK3β signaling. Treatment with SGC707, a selective PRMT3 inhibitor, effectively reduces tau hyperphosphorylation and demonstrates therapeutic promise for PART and potentially other tauopathies. Collectively, this study defines the PRMT3/H4R3me2a/miR-448 axis as a critical regulatory pathway in tau hyperphosphorylation within PART, underscoring the potential of PRMT3 inhibition as a targeted therapeutic strategy for tauopathies.}, archive = {J_ADVS}, author = {Haotian Liu and Xinnan Liu and Fengyuan Tian and Yashuang Chen and Jingying Li and Xue Wang and Wenying Qiu and Xia Wang and Chao Ma and Wei Ge}, doi = {10.1002/advs.202506044}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2506044}, shortjournal = {Adv. Sci.}, title = {PRMT3-mediated H4R3me2a promotes primary age-related tauopathy by driving tau hyperphosphorylation in neuron}, volume = {12}, year = {2025}, }
• (2025). Solar-powered hierarchical microenvironments with authigenic multi-field synergies for simultaneous extraction of freshwater and cesium. ADVS, 12(28), 2505997. (www)

  @article{ , abstract = {The escalating global resource and environmental crisis has intensified the urgent demand for efficiently extracting freshwater and critical metals from contaminated water sources, particularly nuclear-contaminated seawater. Herein, a biomass-based solar-powered hierarchical self-extraction micro-network (BSSM) is proposed and presented, an innovative system that seamlessly integrates solar-driven freshwater generation with highly selective cesium ion (Cs + ) extraction. A bamboo-derived biochar with surface-loaded cobalt oxide nanoparticles (CoO NPs) is prepared and utilized to comprehensively validate the BSSM's efficacy. Leveraging hierarchically engineered microenvironments with authigenic multi-field synergies, the designed BSSM achieves a high freshwater production rate of 3.3 kg m −2 day −1 and an impressive Cs + extraction capacity of 34.58 mg g −1 . In conclusion, this study establishes a transformative paradigm for resource recovery, providing a scalable and eco-friendly panacea to address pressing global issues, including water scarcity, nuclear pollution, and resource security.}, archive = {J_ADVS}, author = {Liuyan Zhu and Lin Zhu and Ting Shi and Ke Zhao and Wenwen He and Lu Han and Zeying Jin and Jialin Kang and Shanfu Sun and Ningning Cao and Zhen Yu}, doi = {10.1002/advs.202505997}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505997}, shortjournal = {Adv. Sci.}, title = {Solar-powered hierarchical microenvironments with authigenic multi-field synergies for simultaneous extraction of freshwater and cesium}, volume = {12}, year = {2025}, }
• (2025). Heterojunction derived efficient charge separation for high sensitivity self-powered flexible photodetectors toward real-time heart rate monitoring. ADVS, 12(28), 2505945. (www)

  @article{ , abstract = {Real-time and accurate heart rate monitoring is crucial in the field of disease prevention and early diagnosis. Compared with the conventional rigid heart rate sensors, wearable flexible devices have unique advantages, such as convenient, high comfortable to the skin, and low data extraction errors. Currently, the available flexible electronic devices encounter with large power consumption, low detectivity, and slow response time, restricting their further commercial applications. Herein, flexible self-powered photodetectors (PDs) are developed by the synergistic strategy of engineering CsPbI 3 :Ho 3+ @SnS quantum dots (QDs) p - n heterojunctions and doping SnS QDs into spiro-OMeTAD hole transport layer (HTL). The designing CsPbI 3 :Ho 3+ @SnS QDs p - n heterojunctions as the photosensitive layer to effectively enhance the built-in field, reduce defect density, and boost the charge separation efficiency. Meanwhile, the high hole mobility and suitable energy band structure of p -type SnS QDs are doped into spiro-OMeTAD HTL, which can improve the hole extraction, and balance electron and hole mobilities. Such flexible self-powered PDs exhibit excellent sensitivity and stability with high responsivity (0.58 A W −1 ) and detectivity (1.13×10 13 Jones), and fast response time (98.8 µs). The flexible self-powered PDs are further integrated with the light-emitting diodes (LEDs) as a photoplethysmography (PPG) system, realizing real-time and accurate heart rate monitoring.}, archive = {J_ADVS}, author = {Nan Ding and Ge Zhu and Xiaotao Zhang and Wen Xu and Hailong Liu and Yanan Ji and Yuanzheng Chen and Bin Dong}, doi = {10.1002/advs.202505945}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505945}, shortjournal = {Adv. Sci.}, title = {Heterojunction derived efficient charge separation for high sensitivity self-powered flexible photodetectors toward real-time heart rate monitoring}, volume = {12}, year = {2025}, }
• (2025). Enhancing silicon compound heterojunction solar cells with vanadium-doped MoOX as hole transport layers. ADVS, 12(28), 2505929. (www)

  @article{ , abstract = {Crystalline silicon (c-Si) solar cells dominate the global market, and the development of eco-friendly and cost-effective c-Si compound solar cells with carrier-selective passivated contacts has attracted increasing attention. This work investigated the impact of oxygen vacancies (V O ) and vanadium (V) doping on molybdenum trioxide (MoO X ), using a combination of first-principles calculations and device simulations. These V O defects accumulated from bulk to surface with lower energy barrier of 1.7 eV, compared to 3.4 eV on surface and 3.8 eV from surface to bulk. The surface V O significantly decreased MoO X work function from 6.1 eV to 4.8 eV，considering alteration in surface charges from +4 µC cm −2 to -8 µC cm −2 . Vanadium doping increased V O transport barrier by 0.1 eV, suppressing defect migration. Meanwhile, it raised work function by 0.26 eV and widened the bandgap by 0.6 eV. As hole transport layer, V-doped MoO X on illuminated side of c-Si solar cells boosted absolute efficiency by 1.0%, compared to MoO X on rear side; of this increase, 0.2% was attributed to higher work function and 0.8% was due to reduced optical losses. These findings emphasize V-doped MoO X in enhancing c-Si compound solar cell performance and in promoting the development of efficient photovoltaic technologies.}, archive = {J_ADVS}, author = {Hongbo Cai and Xiqi Yang and Xiaofei Xu and Qinghua Zeng and Shenghou Zhou and Zilong Zheng and Dongdong Li and Yongzhe Zhang and Hui Yan}, doi = {10.1002/advs.202505929}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505929}, shortjournal = {Adv. Sci.}, title = {Enhancing silicon compound heterojunction solar cells with vanadium-doped MoOX as hole transport layers}, volume = {12}, year = {2025}, }
• (2025). Untying surface chemistry and emulsion stability to construct multifunctional pickering emulsion SERS sensors for pretreatment-free quantitative analysis in bio-media. ADVS, 12(28), 2505714. (www)

  @article{ , abstract = {Plasmonic Pickering emulsions have immense potential as enhancing substrates in surface-enhanced Raman spectroscopy (SERS). Traditionally, the functional nanoparticles also act as the emulsion stabilizer, so that their surface chemistry is tied directly to emulsion stability. However, this has meant that adsorption of molecules to the plasmonic nanoparticles destabilizes the emulsion system, which severely limits the use of Pickering emulsions in SERS. Here, we used a dual-particle approach to create plasmonic Pickering emulsions, in which emulsion stability is maintained solely by one type of nanoparticle so that the other could be used to provide functionality without constraints to its surface properties. This allowed us to construct multiwalled carbon nanotubes-Au@Prussian blue Pickering emulsion SERS sensors with integrated internal standards and filtration functionalities, which enabled quantitative, biphasic and multiplex analysis of discrete molecules in serum. The synthetic approach used in this work can be readily extended to form Pickering emulsions carrying functional components with arbitrary surface functionalities, which paves the way for advanced applications in sustainability and healthcare.}, archive = {J_ADVS}, author = {Yingrui Zhang and Chunchun Li and Ruairi Carland and Ziwei Ye and Steven E. J. Bell and Yikai Xu}, doi = {10.1002/advs.202505714}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505714}, shortjournal = {Adv. Sci.}, title = {Untying surface chemistry and emulsion stability to construct multifunctional pickering emulsion SERS sensors for pretreatment-free quantitative analysis in bio-media}, volume = {12}, year = {2025}, }
• (2025). PHOSPHO1 suppresses ferroptosis in retinal pigment epithelial cells by reducing the levels of phosphatidylethanolamine molecular species. ADVS, 12(28), 2505359. (www)

  @article{ , abstract = {Iron-induced lipid peroxidation of phosphatidylethanolamine (PE) species is a key driver of ferroptosis in retinal pigment epithelial (RPE) cells, a process closely associated with age-related macular degeneration (AMD). The previous studies have demonstrated that induced retinal pigment epithelial (iRPE) cells generated by transcription factor-mediated reprogramming exhibit superior therapeutic efficacy in treating AMD. In this study, it is found that these iRPE cells are resistant to ferroptosis and further identified phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1) as a critical regulator underlying ferroptosis resistance. Mechanistically, PHOSPHO1 inhibits ferroptosis through two distinct mechanisms. First, it reduces PE levels in the endoplasmic reticulum, thereby limiting PE-derived lipid peroxidation. Second, it suppresses autophagy and ferritinophagy, leading to a reduction in intracellular free iron accumulation. Experiments using an in vivo rat model confirm that PHOSPHO1 effectively protects RPE cells from ferroptotic damage. These findings highlight PHOSPHO1 as a potential therapeutic target for AMD, providing insights into novel ferroptosis-based intervention strategies.}, archive = {J_ADVS}, author = {Zhiyang Chen and Xiaoman Zhu and Michael Mingze Lu and Qingjian Ou and Xueying Wang and Zhenzhen Zhao and Qi Shen and Qian Wang and Zhe Wang and Jing-Ying Xu and Caixia Jin and Furong Gao and Juan Wang and Jingfa Zhang and Jieping Zhang and Xiaoliang Jin and Yanlong Bi and Lixia Lu and Guo-Tong Xu and Haibin Tian}, doi = {10.1002/advs.202505359}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505359}, shortjournal = {Adv. Sci.}, title = {PHOSPHO1 suppresses ferroptosis in retinal pigment epithelial cells by reducing the levels of phosphatidylethanolamine molecular species}, volume = {12}, year = {2025}, }
• (2025). Water management fault diagnosis by operando distribution of relaxation times analysis for anion exchange membrane fuel cells. ADVS, 12(28), 2505304. (www)

  @article{ , abstract = {Timely and effective fault diagnosis is essential to ensure the reliability and longevity of anion exchange membrane fuel cells (AEMFCs). This study employs operando electrochemical impedance spectroscopy (EIS) measurements and distribution of relaxation times (DRT) analysis to detect water management faults in both anode and cathode electrodes. EIS measurements are performed under diverse operating conditions, revealing three distinct frequency ranges associated with ion transport, charge transfer, and mass transport processes, and elucidating their contributions to voltage loss. Building on these findings, DRT analysis is further applied to explore the behavior and variation of polarization impedance under different water management fault conditions. Compared with the reference case, anode flooding reduces ion transport resistance by up to 37.1%, while increasing charge transfer and mass transport resistances by 61.8% and 219.2%, respectively. Conversely, cathode flooding results in a 33.5% increase in charge transfer resistance, with minimal impact on mass transport resistance. These quantitative insights provide a novel and effective diagnostic tool for distinguishing water management fault types (flooding or drying) and their location (anode or cathode), offering valuable data to support the implementation of water management control strategies that enhance performance and extend the lifespan of commercial AEMFC stacks.}, archive = {J_ADVS}, author = {Haodong Huang and Zijie Zhang and Cailin Xiao and Jiapeng Liu and Zheng Li and Yuting Jiang and Lei Wei and Tianshou Zhao and Francesco Ciucci and Lin Zeng}, doi = {10.1002/advs.202505304}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505304}, shortjournal = {Adv. Sci.}, title = {Water management fault diagnosis by operando distribution of relaxation times analysis for anion exchange membrane fuel cells}, volume = {12}, year = {2025}, }
• (2025). Nanoreactor-driven uniform nano ZnS deposition in tunable porous carbon spheres for high-performance zn-S batteries. ADVS, 12(28), 2505218. (www)

  @article{ , abstract = {Zn-S batteries have garnered widespread attention in recent years due to their higher safety and low cost. However, challenges such as incomplete sulfur redox reactions and the tendency of ZnS to agglomerate have impeded the continued advancement of high-performance Zn-S batteries. Hollow hierarchical porous carbon spheres (HCs) are designed as efficient sulfur hosts for Zn-S batteries. The tailored HCs, featuring optimized shell thickness, hierarchical porosity, facilitate uniform nano-ZnS deposition, and improve ion/electron transport, which are revealed by in situ impedance technology. This nano reactor design ensures highly reversible S-ZnS conversion, reducing internal polarization and mitigating structural degradation. Electrochemical tests demonstrate outstanding cycling stability, with minimal capacity decay (0.068%) over 500 cycles, and 463 mAh g −1 reversible capacity at 5 A g −1 . Finite element simulations further confirm the effective stress dispersion of HCs, preserving electrode integrity. This work provides a promising strategy for developing high-performance Zn-S batteries.}, archive = {J_ADVS}, author = {Yuxuan Jiang and Bingxin Sun and Dan Wang and Yan Yan and Mohsen Shakouri and Han-Yi Chen and Wang Zhang and Rongmei Zhu and Huan Pang}, doi = {10.1002/advs.202505218}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505218}, shortjournal = {Adv. Sci.}, title = {Nanoreactor-driven uniform nano ZnS deposition in tunable porous carbon spheres for high-performance zn-S batteries}, volume = {12}, year = {2025}, }
• (2025). Fullerene c70-encapsulated tetrathiafulvalene-co porphyrin covalent organic framework: Driving multistep charge transfer to boost CO2 photoreduction. ADVS, 12(28), 2505161. (www)

  @article{ , abstract = {Constructing an efficient charge transfer system can significantly enhance photocatalytic CO 2 reduction, yet efficient construction strategies remain to be explored. In this work, fullerene C 70 is encapsulated into the tetrathiafulvalene-Co porphyrin (TTF-CoTPP) COF to fabricate an efficient photocatalyst C 70 @COF. Transient absorption (TA) spectra indicate that C 70 significantly promotes photogenerated charge separation (0.3 ps), subsequently driving multistep charge transfer within the composite system. This process ultimately yields a long-lived charge-separated state, TTF •+ -CoTPP-C 70 •− (>5 ns). Density functional theory (DFT) calculation reveals that the encapsulation of C 70 forms a new electron transfer pathway and reduces the energy barrier for * COOH intermediate formation. The C 70 @COF exhibits a remarkable CO production rate of 4963.24 µmol g h −1 , a 1.95-fold enhancement over the pristine COF. This work highlights the potential of fullerene in boosting photocatalytic CO 2 reduction performance and offers a facile strategy to design novel COF-based photocatalysts.}, archive = {J_ADVS}, author = {Ying Jiang and Chong Wang and Tianyang Dong and Yupeng Song and Tao Wang and Haibing Che and Hua Sheng and Bo Wu and Chunru Wang}, doi = {10.1002/advs.202505161}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505161}, shortjournal = {Adv. Sci.}, title = {Fullerene c70-encapsulated tetrathiafulvalene-co porphyrin covalent organic framework: Driving multistep charge transfer to boost CO2 photoreduction}, volume = {12}, year = {2025}, }
• (2025). Logarithmic helical design for reversed magnetic field in magnetoelastic soft matters with giant current outputs. ADVS, 12(28), 2505157. (www)

  @article{ , abstract = {Magnetoelastic soft materials are widely used in soft bioelectronics. However, mechanical deformation usually induces minimal changes in magnetic flux, limiting electrical outputs. To overcome this limitation, a two-step process is employed to enhance the variation in magnetic flux density under mechanical force. On one hand, the helical structural design enables the magnetic membrane to flip completely, reversing the magnetic field. On the other hand, the applied mechanical force induces strain within the magnetoelastic membrane, leading to variations in magnetic flux density. A complete 180° reversal of the magnetic field is achieved using a logarithmic helical structure, resulting in a 200% increase in magnetic flux variation and a peak current of 6.34 mA. Following structural optimization, the current density reached an impressive 7.17 mA cm −2 . Using this rationally designed logarithmic helix model, a knee pad is developed for wearable energy harvesting from human body movement. The device can generate a current of up to 2.83 mA, providing sufficient power for various small electronics, including smartphones, LED lights, headlamps, and rechargeable batteries. This achievement represents a significant milestone in advancing high-performance wearable biomechanical energy harvesting.}, archive = {J_ADVS}, author = {Xiaojun Chen and Farid Manshaii and Dianyu Tang and Yizhuo Xu and Zhuofan Li and Manhui Chen and Peng Chen and Yike Li and Shanfei Zhang and Lei Yang and Jun Chen and Bin Su}, doi = {10.1002/advs.202505157}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2505157}, shortjournal = {Adv. Sci.}, title = {Logarithmic helical design for reversed magnetic field in magnetoelastic soft matters with giant current outputs}, volume = {12}, year = {2025}, }
• (2025). Bionic artificial leaves based on AIE-active supramolecular hydrogel for efficient photocatalysis. ADVS, 12(28), 2504993. (www)

  @article{ , abstract = {A novel hydrogel-based biomimetic artificial leaf is fabricated by integrating host-guest interactions with covalent bonding. Specifically, a water-soluble tetraphenylethylene-embedded pillar[5]arene ( m -TPEWP5 ), which exhibits aggregation-induced emission (AIE) property, is synthesized as the host molecule. An amphiphilic guest G is introduced to form a stable complex ( HGSM ) via non-covalent interactions. Subsequent copolymerization of HGSM with gelatin methacryloyl ( GelMA ) yields a hydrogel network ( HGGelMA ), which not only exhibits AIE characteristics but also enables encapsulation of the acceptor eosin Y (ESY), thereby resulting in the construction of an artificial light-harvesting system HGGelMA ⊃ESY that serves as a biomimetic leaf. To emulate natural photosynthesis more closely and optimize the utilization of the collected energy, two organic reactions are performed within this artificial leaf: dehalogenation of bromoacetophenone derivatives and coupling of benzylamine. These reactions demonstrate remarkable catalytic activity and recycling ability during the photocatalytic process.}, archive = {J_ADVS}, author = {Rongbo Zhang and Xueqi Tian and Minzan Zuo and Tao Zhang and Srikala Pangannaya and Xiao-Yu Hu}, doi = {10.1002/advs.202504993}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504993}, shortjournal = {Adv. Sci.}, title = {Bionic artificial leaves based on AIE-active supramolecular hydrogel for efficient photocatalysis}, volume = {12}, year = {2025}, }
• (2025). Generalized phase tailoring of arbitrary orthogonal polarizations in meta-structure with high-order geometric symmetry. ADVS, 12(28), 2504918. (www)

  @article{ , abstract = {Symmetry, a core principle of aesthetics, plays a crucial role in both physics and mathematics. Recent investigations into high-symmetry meta-structures (C m , m ≥ 3) have revealed intriguing concepts and phenomena in optics and materials science. However, increasing symmetry introduces challenges in tailoring anisotropy, limiting the potential of highly symmetric structures for functional wavefront engineering. While nonlinear geometric Berry phase and generalized geometric phase have enabled circular polarization control in C m ( m ≥ 3) meta-structures, these approaches are inherently spin-dependent and restricted to circular polarization states. Here, shape tailoring, including modifications to unit cell dimension and C m meta-structure parameters is presented, to effectively enhance the anisotropy and phase control capabilities of C m ( m ≥ 3) meta-structures. By further incorporating generalized geometric phase, independent phase control of arbitrary orthogonal polarization states is achieved, and validated both numerically and experimentally. This generalized framework enhances the wavefront tailoring capacity of C m ( m ≥ 3) meta-structures and has substantial potential for integrating flexible wavefront functions with high-symmetry-driven exotic phenomena. Moreover, this approach offers inspiration for further applications in fields such as condensed matter physics and materials science, i.e., integrating the symmetry of the unit cell and lattice.}, archive = {J_ADVS}, author = {Kai Qu and Ke Chen and Qi Hu and Weixu Yang and Junming Zhao and Tian Jiang and Yijun Feng}, doi = {10.1002/advs.202504918}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504918}, shortjournal = {Adv. Sci.}, title = {Generalized phase tailoring of arbitrary orthogonal polarizations in meta-structure with high-order geometric symmetry}, volume = {12}, year = {2025}, }
• (2025). Magnesium-mediated electrochemical synthesis of ammonia. ADVS, 12(28), 2504882. (www)

  @article{ , abstract = {Metal-mediated electrochemical synthesis of ammonia (NH 3 ) is a promising method to activate N 2 at room temperature. While a Li-mediated approach has been optimized to produce NH 3 at high current density and selectivity, Li's scarcity and its highly negative plating potential limit scalability and energy efficiency. Alternative mediators have been proposed, but only Ca has shown some promise, achieving ≈50% Faradaic efficiency (FE), though requiring voltages beyond −3 V. Here, we report a Mg-mediated nitrogen reduction reaction (Mg-NRR), where N 2 is activated on Mg to form Mg 3 N 2 , followed by protolysis to release NH 3 and regenerate Mg. A notable NH 3 FE of 25.28 ± 3.80% is achieved at a current density of −45 mA cm −2 , corresponding to an NH 3 partial current density of −11.30 ± 1.77 mA cm −2 under 6 bar N 2 . Isotope-labeled experiments confirm that NH 3 originates from N 2 , with similar FE (25.15 ± 1.01%). Importantly, NH 3 production is demonstrated at a total cell potential as low as −3 V. This Li-free Mg-NRR system offers key advantages, including lower energy input and use of earth-abundant materials, making it a scalable route for sustainable NH 3 synthesis.}, archive = {J_ADVS}, author = {Ishita Goyal and Vamsi V. Gande and Rajan R. Bhawnani and Rebecca Hamlyn and Ahmed A. Farghaly and Meenesh R. Singh}, doi = {10.1002/advs.202504882}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504882}, shortjournal = {Adv. Sci.}, title = {Magnesium-mediated electrochemical synthesis of ammonia}, volume = {12}, year = {2025}, }
• (2025). Wireless in situ catalytic electron signaling-mediated transcriptomic reprogramming for neuron regeneration via adaptable antennas. ADVS, 12(28), 2504786. (www)

  @article{ , abstract = {Electron signaling and oxygen level are vital for regulating neural-cell fate and brain recovery. However, clinical challenges arise from the short half-life and the difficulty of spatiotemporally controlled oxygen release and electric signals. In this study, a wireless-charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on-demand O 2 release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood vessels and neurons in vivo. SOCO also reduces TBI glial scarring by reducing activated microglia and stellate cells, promoting infiltration of new neurons. In whole-brain analyses, effective somatostatin (Sst) production inhibits gamma-aminobutyric acid (GABA) synthesis in injured areas, thereby improving brain function and behavioral recovery. Furthermore, spatial multiomics combined with single-cell deconvolution analysis reveals the treatment reprogramming in vivo brain transcriptome of angiogenic markers (Il1a, Lgals3) and GABAergic pathway via modulation of GAD65/67 activity, guiding angiogenesis and neuronal regeneration. This in situ catalytic SOCO with noncontact AMF presents an “electromagnetic messenger”-based therapeutics for reprogramming the neuro-regeneration and brain function recovery in TBI.}, archive = {J_ADVS}, author = {Hoi Man Iao and Chih-Ying Chen and Ya-Hui Lin and Wan-Chi Pan and Chun-Yi Liang and Hsiu-Ching Liu and Lo-Jei Ching and Pei-Yu Weng and Min-Ren Chiang and Ru-Siou Hsu and Tsu-Chin Chou and I-Chi Lee and Lun-De Liao and Li-An Chu and Shih-Hwa Chiou and Shang-Hsiu Hu}, doi = {10.1002/advs.202504786}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504786}, shortjournal = {Adv. Sci.}, title = {Wireless in situ catalytic electron signaling-mediated transcriptomic reprogramming for neuron regeneration via adaptable antennas}, volume = {12}, year = {2025}, }
• (2025). Direct and low-temperature regeneration of degraded LiFePO₄ cathodes at ambient conditions using green and sustainable deep eutectic solvent. ADVS, 12(28), 2504683. (www)

  @article{ , abstract = {The definite lifespan of lithium iron phosphate (LiFePO 4 , LFP) batteries necessitates the advancement of cost-effective, nature-friendly, and productive recycling techniques for spent LFP batteries. In this study, ethylene glycol (C 2 H 6 O 2 ), a sustainable and economical small organic molecule, is employed as a multifunctional hydrogen-bonding donor, along with lithium chloride (LiCl), a readily accessible Li source and hydrogen-bonding acceptor. Together, they form a novel Li-salt deep eutectic solvent (DES) through hydrogen bonding interactions. This DES directly repairs and rejuvenates the spent cathode material (S-LFP) at 80 °C. The Li-salt DES not only replenishes the depleted Li in S-LFP and reduces the adverse effects of Li–Fe antisite defects but also establishes a reducing environment that facilitates the reversion of degraded Fe(III) species in S-LFP back to their original Fe(II) state. Consequently, the regenerated LFP exhibits remarkable electrochemical behavior, delivering an initial capacity of 155.6 mAh g −1 at 0.1 C and retaining 93% of its initial capacity after 300 cycles at 1 C. This approach can be scaled up to treat large quantities of LFP cathode material recovered from fully retired batteries, presenting a practical pathway toward large-scale recycling of spent LFP batteries in the future.}, archive = {J_ADVS}, author = {Yixin Lin and Tiansheng Wang and Chaochao Gao and Xiaoxuan Zhang and Wen Yu and Mi Wang and Chao Yang and Jiaheng Zhang}, doi = {10.1002/advs.202504683}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504683}, shortjournal = {Adv. Sci.}, title = {Direct and low-temperature regeneration of degraded LiFePO₄ cathodes at ambient conditions using green and sustainable deep eutectic solvent}, volume = {12}, year = {2025}, }
• (2025). 36-channel spin and wavelength co-multiplexed metasurface holography by phase-gradient inverse design. ADVS, 12(28), 2504634. (www)

  @article{ , abstract = {Metasurface holography has emerged as a versatile tool for manipulating light at subwavelength scales, offering enhanced capabilities in multiplexing high-resolution holographic images. However, the scalability of channel multiplexing remains a significant challenge. In this paper, a high-capacity single-cell metasurface is presented capable of maximizing channels by multiplexing holographic images across both spin and wavelength using a single-phase map. The achievement of simultaneous multiplexing of left- and right-circular polarization states is detailed across a broad spectral range, from visible to near-infrared wavelengths, by using a single-cell metasurface, optimized through an inverse design to minimize loss between the target and output images by automatic differentiation. The phase profile is optimized to encode multiple holographic images without requiring complex meta-atoms, thereby reducing the fabrication complexity while maintaining high performance. Using this method, two metasurface implementations are demonstrated, an 8-channel hologram covering both the visible and near-infrared regions and a 36-channel hologram operating in the full-visible spectrum across 18 wavelengths separated by 20-nm intervals. Furthermore, noise-related loss functions are incorporated into the optimization process to suppress background noise and minimize inter-channel crosstalk, resulting in significantly improved image quality and fidelity. This approach offers a reliable solution for further photonic applications such as displays, optical data storage, and information encryption.}, archive = {J_ADVS}, author = {Cherry Park and Youngsun Jeon and Junsuk Rho}, doi = {10.1002/advs.202504634}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504634}, shortjournal = {Adv. Sci.}, title = {36-channel spin and wavelength co-multiplexed metasurface holography by phase-gradient inverse design}, volume = {12}, year = {2025}, }
• (2025). Laser-induced coal-based porous graphene as anode toward advanced lithium-ion battery. ADVS, 12(28), 2504592. (www)

  @article{ , abstract = {Graphene have been considered as the one of the most promising anode materials for the next generation lithium-ion batteries (LIBs) due to its unique properties compared to that of the commercial available graphite anode. However, the tedious preparation process, high cost and easy aggregation of 2D graphene caused by the strong van der Waals interactions among nanosheets affect the high reversible capacity of graphene for LIBs. Herein, a laser-induced strategy employing bituminous coal as a precursor for the preparation of porous graphene-based materials (LIG-B) is reported. LIG-B exhibits a porous foam-like structure and an enlarged interlayer spacing, which is larger than that of graphene with typical AB stacking. As the anode for LIBs, the LIG-B shows a high specific capacity of 400 mAh g −1 at the current density of 100 mA g −1 , and up to 95.0% of the initial reversible capacity retention after 900 cycles at 100 mA g −1 . This result is higher than that of graphene-based materials such as N-doped rGO (200 mAh g −1 ), N-doped Graphene film (150 mAh g −1 ), and rGO film (80 mAh g −1 ). Most importantly, a high capacity of 220 mAh g −1 can be maintained at 2000 mA g −1 , indicating its superior rate capability. This work provides a low-cost method to synthesize porous graphene-based materials with fast Li + /electronic conductivity for high-performance LIBs.}, archive = {J_ADVS}, author = {Xiao Ma and Shiyue Li and Wenhao Tang and Ruiping Liu and Zilong Fu and Shaoqing Wang}, doi = {10.1002/advs.202504592}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504592}, shortjournal = {Adv. Sci.}, title = {Laser-induced coal-based porous graphene as anode toward advanced lithium-ion battery}, volume = {12}, year = {2025}, }
• (2025). Ubiquity of rotational symmetry breaking in superconducting films, from Fe(Te,Se)/Bi2Te3 to nb, and the effect of measurement geometry. ADVS, 12(28), 2504430. (www)

  @article{ , abstract = {FeTe 0.5 Se 0.5 /Bi 2 Te 3 heterostructure is a promising new platform in the journey toward topological quantum computation, considering that first, FeTe 0.5 Se 0.5 (FTS) is itself known to be a topological superconductor (TSC) and second, the heterostructure has topological interface states that can be proximitized into TSC even if FTS fails to become TSC on its own. Here, it is shown that this system exhibits quasi-2D superconductivity, and utilizing the standard in-plane magneto-transport measurements, two-fold anisotropy (a.k.a nematicity) is discovered in longitudinal resistance (R xx ) and critical current (I c ) measurements, even though the system exhibits globally 12-fold symmetry. Then, similar measurements are carried out on a polycrystalline niobium (Nb) thin film, a well-known s-wave elemental superconductor, and a similar two-fold symmetry is found even for this Nb system. This implies either that nematic behavior is ubiquitous or that the in-plane magneto-transport measurement scheme routinely used to detect nematicity, is not a reliable method to probe nematicity. It is shown that the angle-dependent response of vortices in the superconducting regime to the magnetic Lorentz force is very likely the main cause behind the ubiquitous nematic behaviors of this measurement scheme. In other words, this measurement scheme is intrinsically two-fold, and is therefore not suitable to detect the nematicity. Accordingly, all the previous reports of nematicity based on similar measurement practices, reported on various samples, including thin films, bulk crystals, and exfoliated flakes, need to be reinterpreted.}, archive = {J_ADVS}, author = {Debarghya Mallick and Hee Taek Yi and Xiaoyu Yuan and Seongshik Oh}, doi = {10.1002/advs.202504430}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504430}, shortjournal = {Adv. Sci.}, title = {Ubiquity of rotational symmetry breaking in superconducting films, from Fe(Te,Se)/Bi2Te3 to nb, and the effect of measurement geometry}, volume = {12}, year = {2025}, }
• (2025). High-throughput tiling of essential mRNAs increases potency of antisense antibiotics. ADVS, 12(28), 2504284. (www)

  @article{ , abstract = {Antimicrobial resistance is outpacing drug discovery, creating an urgent need for precision-based strategies to counteract resistant pathogens. Peptide nucleic acid (PNA)-based antisense molecules offer a promising approach by selectively inhibiting essential bacterial mRNAs, but their design rules for optimal efficacy remain incompletely understood. Here, a scalable high-throughput platform is developed for the nanomolar-scale one-shot synthesis of PNAs as carrier peptide conjugates (PPNAs). Parallel synthesis of up to 1,536 PPNAs composed of up to 21 PNA or peptide building blocks enabled systematic, base-by-base analysis of RNA hybridization, mRNA inhibition, and antimicrobial activity across nine essential genes in uropathogenic Escherichia coli . The accuracy and robustness of this high-throughput tiling platform are demonstrated through in-depth analysis of the acpP mRNA and identify potent antisense inhibitors of rpsH , ftsZ , and murA . This approach provides an efficient and scalable route to design and optimize PNA-based antimicrobials, facilitating empirical testing across diverse bacterial targets. By enabling large-scale exploration of the relevant mRNA sequence space, the sequence tiling platform accelerates the discovery of antisense-based antimicrobials, offering a scalable strategy to develop precision therapies against various pathogens and combat resistance.}, archive = {J_ADVS}, author = {Giorgia Danti and Linda Popella and Jörg Vogel and Hans M. Maric}, doi = {10.1002/advs.202504284}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504284}, shortjournal = {Adv. Sci.}, title = {High-throughput tiling of essential mRNAs increases potency of antisense antibiotics}, volume = {12}, year = {2025}, }
• (2025). Exploring the correlation between interatomic bonding and corrosion resistance of metallic alloys via combinatorial method. ADVS, 12(28), 2504168. (www)

  @article{ , abstract = {Developing metallic alloys with excellent corrosion resistance is of great significance for ensuring the long-term integrity and reliability of materials in various demanding environments, thereby extending their service life and reducing maintenance costs. However, the corrosion of alloys is a complicated process influenced by many factors, such as composition, structure and surface finishing, and corrosion media. Current evaluations of alloy corrosion resistance involve many steps, which are time-consuming and laborious to explore within a vast compositional space. In this study, 1874 alloys from 8 alloy systems are prepared and characterized using a combinatorial approach. Analyses of the data indicate that corrosion resistance of an alloy is strongly correlated with metal–metal bond strength (ε M–M ) and metal–oxygen bond strength (ε M–O ). Enhanced corrosion resistance can be achieved by alloying elements with high ε M–M and ε M–O . The consideration from interatomic interactions further reveals that adding elements with high ε M–M and ε M–O to a base alloy system actually lowers the critical weight-averaged ε M–M and ε M–O required for corrosion resistance. The ε M–M and ε M–O guided selection of alloying elements is applicable in different alloy systems. This finding will facilitate the fast discovery of novel alloys with superior corrosion resistance.}, archive = {J_ADVS}, author = {Liwei Hu and Fucheng Li and Weijie Xie and Chao Wang and Mingxing Li and Gang Wang and Yanhui Liu}, doi = {10.1002/advs.202504168}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504168}, shortjournal = {Adv. Sci.}, title = {Exploring the correlation between interatomic bonding and corrosion resistance of metallic alloys via combinatorial method}, volume = {12}, year = {2025}, }
• (2025). One-step syntheses of face-centered cubic OsxPt1-x/C with near-zero-overpotential hydrogen evolution from electronic-state engineering. ADVS, 12(28), 2504161. (www)

  @article{ , abstract = {The loading states and crystal structure control of solid solution catalysts, which greatly influence the catalytic performance, have not yet been achieved simultaneously due to the limitations of previous synthetic methodologies. In this work, a one-pot in situ polyol method is developed for the phase-control synthesis of face-centered cubic (fcc)-dominated and well-dispersed immiscible Os x Pt 1-x /C. Most fcc-Os x Pt 1-x /C catalysts exhibit superior hydrogen evolution reaction (HER) catalytic activities compared to those of Pt/C catalysts. Remarkably, the overpotential of fcc-Os 0.3 Pt 0.7 /C in 0.5 m H 2 SO 4 at 10 mA·cm −2 is only 1.0 mV as the top record. In Os 0.5 Pt 0.5 /C and Os 0.3 Pt 0.7 /C, the weakening of H adsorption on Pt sites, resulting from electronic state adjustments induced by Os alloying, modify the reaction pathways by promoting H 2 desorption from more favorable coupled sites, thereby achieving state-of-the-art HER catalytic activities.}, archive = {J_ADVS}, author = {Junyun Gao and Bo Huang}, doi = {10.1002/advs.202504161}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504161}, shortjournal = {Adv. Sci.}, title = {One-step syntheses of face-centered cubic OsxPt1-x/C with near-zero-overpotential hydrogen evolution from electronic-state engineering}, volume = {12}, year = {2025}, }
• (2025). A dual-targeting T6SS DNase drives bacterial antagonism and eukaryotic apoptosis via the cGAS-STING-TNF axis. ADVS, 12(28), 2504086. (www)

  @article{ , abstract = {The Type VI secretion system (T6SS) is a key virulence mechanism utilized by many Gram-negative bacteria to mediate the microbial competition and host pathogenesis. Despite the identification of diverse T6SS effectors targeting eukaryotic or prokaryotic cells, the trans-kingdom T6SS effectors that simultaneously target both eukaryotic and prokaryotic cells remain rarely reported. In this study, it is demonstrated that Yersinia pseudotuberculosis ( Yptb ) T6SS secretes a DNase effector, TkeA, which induces apoptosis in host cells. The translocation of TkeA into host cells causes nuclear DNA damage. This, in turn, activates the DNA-sensing cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway. The activation of the cGAS-STING pathway by TkeA subsequently triggers apoptosis in host cells via extrinsic pathways, with tumor necrosis factor (TNF) signaling playing a critical role. Additionally, TkeA enhances bacterial competition by targeting rival bacteria, thereby promoting host colonization. These findings reveal that the transkingdom T6SS effector TkeA executes a “one weapon, two battlefields” strategy, acting as a trans-kingdom effector that enhances interbacterial competition while inducing apoptosis in host cells through the activation of the cGAS-STING-TNF axis. This highlights a previously unrecognized dimension of bacterial virulence strategies and expands the understanding of host-pathogen interactions involving T6SS effectors.}, archive = {J_ADVS}, author = {Li Song and Lei Xu and Pengfei Zhang and Shuying Li and Yichen Qu and Yixin Zhao and Zhenkun Shi and Ruiqi Ma and Yongdong Li and Yi Chen and Yao Wang and Zhengfan Jiang and Gehong Wei and Xihui Shen}, doi = {10.1002/advs.202504086}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504086}, shortjournal = {Adv. Sci.}, title = {A dual-targeting T6SS DNase drives bacterial antagonism and eukaryotic apoptosis via the cGAS-STING-TNF axis}, volume = {12}, year = {2025}, }
• (2025). Intermediate filament protein BFSP1 maintains oocyte asymmetric division by modulating spindle length. ADVS, 12(28), 2504066. (www)

  @article{ , abstract = {The cytoskeleton is composed of microtubules, microfilaments, and intermediate filaments in cells. While the functions of microtubules and microfilaments have been well elucidated, the roles of intermediate filaments and associated proteins remain largely unknown, especially in meiosis. BFSP1 is an intermediate filament protein mainly expressed in the eye lens to play important roles in the development of congenital cataract. Here, we document that BFSP1 functions as a spindle regulator to drive the oocyte asymmetric division. Specifically, we found that BFSP1 distributed on the spindle apparatus during oocyte meiotic maturation. Depletion of BFSP1 resulted in symmetric division of oocytes, accompanied by the formation of elongated spindles at metaphase I and anaphase/telophase I stages. In addition, immunoprecipitation combined with mass spectrometry analysis identified MAP1B, a microtubule-associated protein, as an interacting partner of BFSP1. Depletion or mutation of MAP1B phenocopied the meiotic defects observed in BFSP1-depleted oocytes, and expression of exogenous MAP1B-EGFP in BFSP1-depleted oocytes recovered the spindle length and asymmetric division. We further determined that BFSP1 recruited molecular chaperone HSP90α on the spindle to stabilize MAP1B, thereby controlling the spindle length. To sum up, our findings reveal a unique meiotic role for BFSP1 in the regulation of spindle dynamics and oocyte asymmetric division.}, archive = {J_ADVS}, author = {Yu Li and Hanwen Zhang and Wenjun Zeng and Yilong Miao and Shaochen Sun and Yu Zhang and Bo Xiong}, doi = {10.1002/advs.202504066}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2504066}, shortjournal = {Adv. Sci.}, title = {Intermediate filament protein BFSP1 maintains oocyte asymmetric division by modulating spindle length}, volume = {12}, year = {2025}, }
• (2025). Strong and fatigue-resistant hydrogels via poor solvent evaporation assisted hot-stretching for tendon repair. ADVS, 12(28), 2503697. (www)

  @article{ , abstract = {It is highly desirable but still remains challenging to develop high-performance hydrogels with satisfactory mechanical properties for tissue engineering. Here, anisotropic yet transparent hydrogels (AHs) are prepared for tendon repair via a facile “poor solvent evaporation assisted hot-stretching” strategy. AHs have great mechanical properties with tensile strength, toughness, and fracture energy as high as 33.14 ± 2.05 MPa, 44.1 ± 3.5 MJ m −3 , and 106.18 ± 7.2 kJ m −2 , respectively. Especially, AHs show unique flaw-insensitive characteristics, and cracks can only deflect along the fiber alignment direction rather than propagate transverse to this direction, showing an interesting self-protection function. The high strength, toughness, and fatigue resistance originate from the hierarchal structure of AHs, i.e., the densified polymeric network comprising fiber bundles and nanofibrils with aligned macromolecular chains, crystalline domains, and intermolecular hydrogen bonds. AHs with superior biocompatibility and swelling resistance can be used to repair rat tendons, and implantation of AHs can promote collagen regeneration for the tendon repair. This study provides a new method to fabricate strong and anti-fatigue hydrogels as a new class of promising materials for soft tissues.}, archive = {J_ADVS}, author = {Huamin Li and Ying Zhang and Haidi Wu and Zhanqi Liu and Cheng Guan and Jin Zhang and Jingyi Chen and Shaohua He and Xuewu Huang and Wancheng Gu and Yiu Wing Mai and Jiefeng Gao}, doi = {10.1002/advs.202503697}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503697}, shortjournal = {Adv. Sci.}, title = {Strong and fatigue-resistant hydrogels via poor solvent evaporation assisted hot-stretching for tendon repair}, volume = {12}, year = {2025}, }
• (2025). Amorphous engineering driving d-orbital high spin configuration for almost 100% 1O2-mediated fenton-like reactions. ADVS, 12(28), 2503665. (www)

  @article{ , abstract = {The inherent atomic disorder in amorphous materials leads to unsaturated atomic sites or dangling bonds, effectively modulating the material's electronic states and rendering it an ideal platform for the growth of single atoms. Herein, the electronic structure of isolated cobalt atoms anchored on amorphous carbon nitride (Co-ACN) is modulated through a substrate amorphization engineering, enabling the thorough removal of pazufloxacin (PZF) in 1 min with a high reaction rate constant ( k 1 ) of 3.504 min −1 by peroxymonosulfate (PMS) activation. Experiments and theoretical calculations reveal that Co-ACN exhibited a higher coordination environment (Co-N 3 ) compared to crystalline Co-CCN (Co-N 2 ). Meanwhile, the t 2g energy level enhancement of Co 3d orbital promotes electron transition from t 2g to e g , inducing more unpaired electrons and thereby driving the transition from a low-spin state (LS, t 2g 6 e g 1 ) to a high-spin state (HS, t 2g 5 e g 2 ). The HS Co-ACN optimized the d-band center, boosted the electronic transfer, and weakened the interaction between Co 3d and O 2p orbitals of HSO 5 − , thereby enabling nearly 100% selective singlet oxygen ( 1 O 2 ) generation, whereas Co-CCN yielded coexisting reactive oxygen species (ROS). This work opens up a new paradigm for regulating the electronic structure of single-atom catalysts at the atomic scale.}, archive = {J_ADVS}, author = {Juanjuan Qi and Qian Bai and Xiuhui Bai and Hongfei Gu and Siyue Lu and Siyang Chen and Qiangwei Li and Xudong Yang and Jianhui Wang and Lidong Wang}, doi = {10.1002/advs.202503665}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503665}, shortjournal = {Adv. Sci.}, title = {Amorphous engineering driving d-orbital high spin configuration for almost 100% 1O2-mediated fenton-like reactions}, volume = {12}, year = {2025}, }
• (2025). Neuronal FGF13 inhibits mitochondria-derived damage signals to prevent neuroinflammation and neurodegeneration in a mouse model of parkinson's disease. ADVS, 12(28), 2503579. (www)

  @article{ , abstract = {Fibroblast growth factor homologous factors (FHFs) are highly expressed in the central nervous system (CNS). It is demonstrated that the FHFs subfamily plays cardinal roles in several neuropathological diseases, while their involvement in Parkinson's disease (PD) has been so far scarcely investigated. From the publicly available Gene Expression Omnibus (GEO) datasets, FHF2 (also known as fibroblast growth factor 13, FGF13 ) alterations are described in PD patients. Fgf13 gene is significantly decreased in several PD mouse models, and its overexpression alleviates the PD-like pathological phenotype. Although FGF13 is highly expressed in neurons, it functions by preventing glia-dependent inflammatory processes. Mechanistically, FGF13 combines mitochondrial proteins such as MCHT2 (a protein localized on the mitochondrial outer membrane), to anchor mitochondria within the cytoplasm. Under PD-related stress, decreased neuronal FGF13 levels induce the release of the damaged mitochondria, which in turn activate microglia and astrocytes, thereby promoting neurodegeneration. Abacavir, an FDA-applied anti-retroviral drug, is identified to prevent excessive gliosis and neuron loss in both glia-neuron co-cultures and PD mouse models by rejuvenating FGF13 signaling. Collectively, neuronal FGF13 inhibits the transfer of stressed mitochondria to glia, thereby impeding neuroinflammation and neurodegeneration. Abacavir is a promising neuroprotectant and sets a brake to PD progression.}, archive = {J_ADVS}, author = {Nanshan Song and Xiangxu Wang and Luqing Ha and Lamei Hu and Shuyuan Mei and Yue Liang and Yujie Zhao and Xingyin Yang and Qingyu Zhang and Yuanzhang Zhou and Jianhua Ding and Yan Liu and Qigang Zhou and Feng Han and Gang Hu and Ming Lu}, doi = {10.1002/advs.202503579}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503579}, shortjournal = {Adv. Sci.}, title = {Neuronal FGF13 inhibits mitochondria-derived damage signals to prevent neuroinflammation and neurodegeneration in a mouse model of parkinson's disease}, volume = {12}, year = {2025}, }
• (2025). Helicobacter pylori detection based on synergistic electromagnetic and chemical enhancement of surface-enhanced raman scattering in 3D hotspot-activated gold Nanorods/Nano mica Platelets/ZnO quantum dots. ADVS, 12(28), 2503562. (www)

  @article{ , abstract = {Gold nanorods (AuNRs) with a controllable aspect ratio are anchored on the surface of delaminated nano mica platelets (NMPs) in the presence of a cationic interfacial activator and protective agent enabling the positive charging of the AuNR and nanohybrid surfaces. The high anionic charge and specific surface area of NMPs stabilize AuNR growth and benefit the adsorption of anionic analytes. The nanohybrids (AuNRs/NMPs) exhibit a 3D hotspot effect due to self-assembly and feature regularly arranged AuNRs, thus enabling Raman signal enhancement and sensitive (limit of detection (LOD) = 10 −9 m , Raman enhancement factor (EF) = 2.0 × 10 8 ) and reproducible (relative standard deviation (RSD) = 8.82%) adenine detection based on surface-enhanced Raman scattering (SERS). The further incorporation of ZnO quantum dots (QDs) affords nanohybrids (AuNRs/NMPs/ZnO QDs) that exhibit electromagnetic and chemical signal enhancement mechanisms and enable more sensitive and reproducible adenine detection (LOD = 10 −10 m , EF = 1.6 × 10 9 , RSD = 7.66%). AuNRs/NMPs/ZnO QDs are subsequently used for the selective and sensitive SERS-based detection of Helicobacter pylori (LOD = 90 CFU mL −1 ). Thus, this work paves the way for the noninvasive, nonfluorescent labeling, rapid, sensitive, selective, and reproducible detection of H. pylori .}, archive = {J_ADVS}, author = {Ming-Chang Lu and Yung-Chi Yang and Chia-Jung Lee and Chih-Wei Chiu}, doi = {10.1002/advs.202503562}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503562}, shortjournal = {Adv. Sci.}, title = {Helicobacter pylori detection based on synergistic electromagnetic and chemical enhancement of surface-enhanced raman scattering in 3D hotspot-activated gold Nanorods/Nano mica Platelets/ZnO quantum dots}, volume = {12}, year = {2025}, }
• (2025). CD103+ t cells eliminate damaged alveolar epithelial type II cells under oxidative stress to prevent lung tumorigenesis. ADVS, 12(28), 2503557. (www)

  @article{ , abstract = {The nexus between aging-associated immune deteriorations and tumorigenesis of lung cancers remains elusive. In a mouse model with Med23 depletion in T cells ( Med23 −/− ), it is found a strong association between the decline of CD103 + T cells and spontaneous alveolar epithelial type II cell (AT2 cell)-originated lung adenocarcinomas. The reduction of CD103 + T cells in the lung results in an accumulation of AT2 cells bearing oxidative damages, which appears to be the major origin of the lung adenocarcinoma. Functional experiments reveal CD103 + T cells can eradicate oxidative-damage-bearing AT2 cells as well as ROS-dependent, KRAS (G12D)-driven tumorigenesis. In vitro co-cultures prove CD103 + T cells, especially CD103 + CD8 + T cells, exhibit a killing capacity that matches the oxidative stress level in the target cells. In aged animals, it is found the abundance of CD103 + CD8 + T cells in the lung declines with age, accompanied by an accumulation of oxidative-damage-bearing AT2 cells. Collectively, the study establishes the vital function of CD103 + T cells in surveilling epithelial cells under oxidative stress to prevent malignancies, and unravels a potential immuno-dysregulation in the aged lung which contributes to tumorigenesis.}, archive = {J_ADVS}, author = {Yu Xu and Haorui Luo and Jiahao Wang and Haifeng Liu and Luonan Chen and Hongbin Ji and Zimu Deng and Xiaolong Liu}, doi = {10.1002/advs.202503557}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503557}, shortjournal = {Adv. Sci.}, title = {CD103+ t cells eliminate damaged alveolar epithelial type II cells under oxidative stress to prevent lung tumorigenesis}, volume = {12}, year = {2025}, }
• (2025). Self-powered UV dual-band photodetector based on Cs3BiCl6/GaN heterojunction for logical operation and encrypted photo-communication. ADVS, 12(28), 2503498. (www)

  @article{ , abstract = {Dual-band photodetectors have huge potential for application in secure optical communication, multicolor imaging, and logical operation. However, the majority of currently documented dual-band photodetectors suffer from high energy consumption and poor photoresponse performance; especially, the dual-band photodetectors targeted at the UV region have yet not been reported. In this study, for the first time, a self-powered UV dual-band photodetector based on Cs 3 BiCl 6 /GaN heterojunction is designed and fabricated through a dual-source co-evaporation technique. Experiments and theoretical simulations confirm that the unique dual-band absorption characteristics of Cs 3 BiCl 6 and the strong surface-charge recombination near the Cs 3 BiCl 6 surface are the primary factors enabling the achievement of UV dual-band photodetection. Importantly, owing to the well-matched energy band alignment of Cs 3 BiCl 6 and GaN, the photodetectors exhibit ultra-high I on / I off ratio (1 × 10 7 ), large specific detectivity (1.23 × 10 12 Jones), and ultrafast response speed (τ r /τ f = 28 µs/190 µs). Finally, utilizing the UV dual-band characteristics of the fabricated device, the logical operation and encrypted photo-communication applications are successfully demonstrated. The obtained results suggest that the lead-free perovskite Cs 3 BiCl 6 is potentially an attractive candidate for the manufacture of high-performance UV dual-band photodetectors that can be employed in advanced encryption technology.}, archive = {J_ADVS}, author = {Jingli Ma and Fei Zhang and Yakun Xing and Huifang Jiang and Yongtao Tian and Huifang Ji and Xu Chen and Di Wu and Longhui Zeng and Xinjian Li and Chongxin Shan and Zhifeng Shi}, doi = {10.1002/advs.202503498}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503498}, shortjournal = {Adv. Sci.}, title = {Self-powered UV dual-band photodetector based on Cs3BiCl6/GaN heterojunction for logical operation and encrypted photo-communication}, volume = {12}, year = {2025}, }
• (2025). An enhanced “Trapping−Conversion” function enables ultrastable potassium ion storage. ADVS, 12(28), 2503332. (www)

  @article{ , abstract = {Metal chalcogenides (MCs) have emerged as promising candidates for potassium ion battery (KIB) anode materials, yet the sluggish redox kinetics and notorious shuttle effect inescapability lead to inferior rate performance and poor cyclability. Herein, a P-doped PbTe/MXene (P-PbTe/MXene) superstructure is rationally constructed by decorating PbTe on MXene via a hydrothermal reaction and followed by bifunctional P-doping, where P heteroatoms enter both PbTe and MXene lattice. The P-PbTe/MXene anode shows enhanced reaction kinetics and suppressed shuttle effect of polytellurides due to the enhanced chemical adsorption stemming from the low energy gaps between the d-band center and the p-band center of P-MXene. As a result, the P-PbTe/MXene superstructure shows superior potassium storage properties, including high reversible capacity (289.1 mAh g −1 at 0.2 A g −1 after 200 cycles), outstanding rate performance (151.3 mAh g −1 at 20 A g −1 ), and ultrastable cyclability (180.1 mA h g −1 at 2.0 A g −1 after 2000 cycles) in half battery. Also, the P-PbTe/MXene anode exhibits high energy density (186.0 Wh kg −1 at 0.1 A g −1 ) and excellent bending stability in soft-package full cells.}, archive = {J_ADVS}, author = {Zhongquan Wang and Bangjun Wu and Zhenping Qiu and Qingguang Zeng and Aruuhan Bayaguud and Huirong Wang and Zheng Liu and Yiju Li and Yelong Zhang}, doi = {10.1002/advs.202503332}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503332}, shortjournal = {Adv. Sci.}, title = {An enhanced “Trapping−Conversion” function enables ultrastable potassium ion storage}, volume = {12}, year = {2025}, }
• (2025). Hybrid solar spectral-splitting photovoltaic-thermal hydrogen production systems. ADVS, 12(28), 2503205. (www)

  @article{ , abstract = {Utilizing solar energy to produce green hydrogen is sustainable, but achieving high efficiencies remains challenging. In this study, a hybrid solar spectral-splitting photovoltaic-thermal hydrogen (SSPVTH) system is developed. Leveraging emerging membrane-less electrolyzers, this system simultaneously employs photovoltaics and solar thermal energy to maximize solar-to-hydrogen (STH) production efficiency. The SSPVTH system based on gallium arsenide solar cells achieves an STH efficiency of 21.1%, representing a 31.1% relative improvement over a conventional PV-electrolyzer that relies solely on photovoltaic electricity for water electrolysis. When equipped with perovskite photovoltaics, the system attains an STH efficiency of up to 19.0%. Additionally, with the integration of direct current power converters, the system maintains relatively stable performance across varying solar irradiance levels. Overall, this study provides a new design with the potential for achieving high-efficiency hydrogen production through hybrid solar technologies.}, archive = {J_ADVS}, author = {Yu Tian and Pooria Hadikhani and Nada Alati and Bryce S. Richards and Gan Huang}, doi = {10.1002/advs.202503205}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503205}, shortjournal = {Adv. Sci.}, title = {Hybrid solar spectral-splitting photovoltaic-thermal hydrogen production systems}, volume = {12}, year = {2025}, }
• (2025). Ecofriendly upcycling of poly(vinyl chloride) waste plastics into precious metal adsorbents. ADVS, 12(28), 2503157. (www)

  @article{ , abstract = {Global interest in the recycling of precious metals (PMs) in various industrial sectors has spurred the exploration of high-performance PM adsorbents. Unfortunately, many adsorbents exhibit unsatisfactory PM adsorption performance and require complex fabrication protocols and toxic chemicals. Hence, further development of simple, efficient, and eco-friendly adsorbents is necessary. Herein, poly(vinyl chloride) (PVC) waste plastics are simply transformed into high-performance PM adsorbents via benign solvent treatment and hydrazination. The resultant hydrazine-functionalized PVC (h-PVC) plastic can effectively recover gold, palladium, and platinum from real-world leachates owing to its combined reduction and chemisorption mechanisms. The PM-adsorbed h-PVC plastic can be regenerated, calcined into high-purity PMs, or directly employed as a catalyst, demonstrating its practical feasibility. Techno-economic and life-cycle assessments reveal that the h-PVC plastic-utilizing industrial-scale recovery of gold from electronic waste is cost-competitive and environmentally advantageous. The strategy supports environmental and sustainable technologies by enabling the sustainable maintenance of carbon and PM resources and provides an efficient and sustainable method for fabricating advanced adsorbent materials.}, archive = {J_ADVS}, author = {Seung Su Shin and Seungho Lee and Sung-Joon Park and Hansoo Kim and Juyeon Choi and Wangyun Won and Jung-Hyun Lee}, doi = {10.1002/advs.202503157}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503157}, shortjournal = {Adv. Sci.}, title = {Ecofriendly upcycling of poly(vinyl chloride) waste plastics into precious metal adsorbents}, volume = {12}, year = {2025}, }
• (2025). Identification and drug screening of single cells from human tumors on semiconductor chip for cancer precision medicine. ADVS, 12(28), 2503131. (www)

  @article{ , abstract = {Drug screening of primary tumor cells directly assesses the drug efficacy on specific tumors, promoting personalized cancer treatment. The application of a microfluidic platform has realized drug screening using a limited amount of biopsy samples for cancer precision medicine. However, all the techniques face an inevitable issue of not all the primary tumor cells being cancer cells. Here, a system is introduced that integrates single-cell identification and drug screening on one semiconductor chip so that both drug efficacy on cancer cells and drug toxicity on noncancerous cells can be obtained simultaneously. An integrated circuit is built on the semiconductor chip for single-cell electric impedance sensing (IC-ECIS) of ultra-weak signals for distinguishing cancer cells from noncancerous cells without affecting cell vitality. Single-cell identification is validated using breast, lung, and liver cell lines as well as liver cancer specimens from clinical patients. The accuracy on commercial cell lines is ≈80%, and the diagnostic results of tumor tissues are consistent with clinical pathology results. Drug screening is run on the same chip after single cell identification for dual evaluation of drug efficacy and toxicity in both breast cancer models and clinical liver cancer patients. The on-chip drug screening is confirmed with off-chip counterpart experiments in breast cell lines. The effectiveness or ineffectiveness of a drug screened on the IC-ECIS chip demonstrated consistency in the presence or absence of specific mutations in the drug-related genes determined via exome sequencing of individual liver tumors, validating the method for precision medicine.}, archive = {J_ADVS}, author = {Wenhao Hui and Ka-Meng Lei and Yingying Liu and Xinru Huang and Yunlong Zhong and Xiaojun Chen and Mingji Wei and Jie Yan and Ren Shen and Pui-In Mak and Rui P. Martins and Shuhong Yi and Ping Wang and Yanwei Jia}, doi = {10.1002/advs.202503131}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503131}, shortjournal = {Adv. Sci.}, title = {Identification and drug screening of single cells from human tumors on semiconductor chip for cancer precision medicine}, volume = {12}, year = {2025}, }
• (2025). Gas bubbles from biodegradable magnesium implants convey mechanical cues and promote immune cell stimulation. ADVS, 12(28), 2503123. (www)

  @article{ , abstract = {In ever-increasing numbers, patients are treated with biodegradable magnesium implants. While gas bubbles frequently arise in soft tissue overlying magnesium implants, their biological implications remain uncertain. This study investigates how bubble accumulation and evolution across various biological lengths and time scales influence adjacent tissue and cell behavior in rats. Bubbles accumulate in tissues around magnesium during initial postimplantation days, then fully resorb. Alterations in tissue and cell geometry around bubbles coincide with accumulation of cells, many with macrophage phenotypes, and increased expression of the mechanosensitive ion-channel Piezo1. Using spatially resolved transcriptomics, strong proinflammatory pathway activation is revealed near bubbles with marked expression of the proliferative macrophage marker secreted phosphoprotein 1 ( Spp1 ). Spatial transcriptomics also reveals strong enrichment of cytoskeletal rearrangement genes, demonstrating that cells respond to mechanical cues from bubbles. Notably, both time and bubble–implant distance strongly influence the cellular response. Over time, as bubbles are located farther from the implant, regenerative processes decline, and inflammation predominates. These findings suggest that bubbles from magnesium implant degradation create an intricate local response influencing tissue healing through inflammatory and mechanical pathways. This study underscores the need for magnesium implants with controlled gas release and meticulous monitoring of bubble evolution in patients.}, archive = {J_ADVS}, author = {Heithem Ben Amara and Jincy Philip and Omar Omar and Peter Thomsen}, doi = {10.1002/advs.202503123}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2503123}, shortjournal = {Adv. Sci.}, title = {Gas bubbles from biodegradable magnesium implants convey mechanical cues and promote immune cell stimulation}, volume = {12}, year = {2025}, }
• (2025). Manganese-catalyzed electrochemical diazidation of dehydroalanine peptides. ADVS, 12(28), 2502711. (www)

  @article{ , abstract = {Dehydroalanine (Dha), a readily introducible non-canonical amino acid, is widely used for protein post-translational modification (PTM) and site-specific labeling of peptides and proteins. Despite its growing applications in biological systems, the precise modification of unnatural amino acid peptides and their conversion into functionalized endogenous peptides remain underdeveloped. To address this challenge, a novel peptide modification strategy is developed based on a manganese-catalyzed electrochemical radical relay process between dehydroalanine peptides and sodium azide. This method demonstrates excellent functional group tolerance, accommodating amino acids with sensitive groups and even drug molecules, achieving yields of up to 99%. Mechanistic studies reveal that the reaction proceeds via a Mn(II)-mediated electrochemical generation of azidyl radicals (N 3 ⚫), which undergo regioselective addition to the Dha moiety, enabling efficient and site-selective diazidation. The rapid diazidation strategy presented here provides a robust and efficient approach for converting unnatural amino acids into functionalized endogenous peptides, offering significant potential for applications in peptide chemistry and bioconjugation.}, archive = {J_ADVS}, author = {Xinwei Hu and Chengwei Zheng and Xiaotong Song and Balati Hasimujiang and Mu Chen and Zhixiong Ruan}, doi = {10.1002/advs.202502711}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2502711}, shortjournal = {Adv. Sci.}, title = {Manganese-catalyzed electrochemical diazidation of dehydroalanine peptides}, volume = {12}, year = {2025}, }
• (2025). Mesoporous gold nanospheres confined platinum nanoclusters as robust ROS and oxygen nanogenerators for NIR-II hyperthermia cancer therapy. ADVS, 12(28), 2502688. (www)

  @article{ , abstract = {While massive studies are focused on platinum (Pt)-based nanozyme for antitumor therapies, their therapeutic efficiency is deficient due to the weak catalytic activity in the highly complex tumor microenvironment. Herein, mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) as robust hydroxyl radical and oxygen nanogenerators are achieved for multimodal therapies. Benefiting from the confinement effect of the mesopores in the MGNSs, the Pt nanoclusters (Pt NCs) demonstrate enhanced stability and catalytic activity, with a catalytic constant (K cat ) of 1.42 × 10 6 s −1 , which is 2 and 5 orders magnitude higher than K cat values of Pt-decorated non-porous gold nanoparticles and pure Pt NCs respectively. Density functional theory (DFT) calculations reveal the proper interaction of intermediates contributes to the ultra-high catalytic activity of MGNSs@Pt. Meanwhile, owing to the local surface plasmon resonance (LSPR) effect in the second near-infrared (NIR-II) bio-window of MGNSs, the nanozymes exhibited high photothermal conversion efficiency up to 43.4%, which enhanced the nanocatalytic damage on cancer cells. This process can induce robust oxidative stress and oxygenation within the tumor, thereby activating the apoptosis pathway for tumor eradication by mitochondrial dysfunction, cell membrane disruption, HIF-1α downregulation as well as caspase 3 activation, which pave the way for multimodal and effective cancer treatment.}, archive = {J_ADVS}, author = {Fei Cun and Jie Chen and Hanxue Li and Yufang Kou and Meiyan Wang and Xiaomin Li and Hui Chen and Jilie Kong}, doi = {10.1002/advs.202502688}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2502688}, shortjournal = {Adv. Sci.}, title = {Mesoporous gold nanospheres confined platinum nanoclusters as robust ROS and oxygen nanogenerators for NIR-II hyperthermia cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Mechanical stress induced NOX2 promotes endothelial dysfunction in ventilator-induced lung injury: Potential treatment with quercetin. ADVS, 12(28), 2502639. (www)

  @article{ , abstract = {Mechanical ventilation (MV) is a treatment that helps people who are unable to breathe on their own. However, the use of MV leads to the development of ventilator-induced lung injury (VILI). Here, it is found that VILI with endothelial barrier disruption is accompanied by elevated reactive oxygen species (ROS) in mice. NADPH oxidase 2 (NOX2, also known as CYBB or gp91phox) is first examined to be the main source of ROS to repress endothelial junction. Besides, 20%-0.5 Hz high cyclic stretch (high CS) significantly increases NOX2 expression and inhibits endothelial junction protein expression. NOX2 activates the downstream Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII)/ Extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling pathway through the regulation of ROS. This pathway is confirmed by high MV stimulation in vivo and high CS in vitro. Of note, quercetin, as an antioxidant, is effective in preventing mechanical stretch-induced endothelial dysfunction by scavenging ROS. Omics data indicated that there is a similar gene expression pattern in cecal ligation and puncture (CLP) and VILI. Pre-administration of quercetin significantly improves the survival rate of mice via inactivating ROS/CaMKII/ERK1/2 axis. Quercetin pre-treatment not only preventes MV-induced lung injury but also attenuates existing inflammation-induced lung injury.}, archive = {J_ADVS}, author = {Tao Jiang and Yabing Zhang and Zhiye Guo and He Ren and Weiyi Hu and Qingping Yao and Yunlong Huo and Yingxin Qi and Kai Huang}, doi = {10.1002/advs.202502639}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2502639}, shortjournal = {Adv. Sci.}, title = {Mechanical stress induced NOX2 promotes endothelial dysfunction in ventilator-induced lung injury: Potential treatment with quercetin}, volume = {12}, year = {2025}, }
• (2025). Gut microbiota modulates obesity-associated skeletal deterioration through macrophage aging and grancalcin secretion. ADVS, 12(28), 2502634. (www)

  @article{ , abstract = {Obesity is associated with skeletal deterioration and increased fracture risk, but the underlying mechanism is unclear. Herein, it is shown that obese gut microbiota promotes skeletal deterioration by inducing bone marrow macrophages (BMMs) senescence and grancalcin (GCA) secretion. Obese mice and those receiving obese fecal microbiota transplants exhibit increased senescent macrophages and elevated GCA expression in the bone marrow. In a study of 40 participants, it is found that obese patients are associated with higher serum GCA levels. It is further revealed that obese gut-microbiota derived lipopolysaccharides (LPS) stimulate GCA expression in senescent BMMs via activating Toll-like receptor 4 pathway. Mice with depletion of the Gca gene are resistant to the negative effects of obesity and LPS on bone. Moreover, neutralizing antibody against GCA mitigates skeletal deterioration in obese mice and LPS-induced chronic inflammation mouse model. The data suggest that the interaction between gut microbiota and the immune system contributes to obesity-associated skeletal deterioration, and targeting senescent macrophages and GCA shows potential of protecting skeletal health in obese population.}, archive = {J_ADVS}, author = {Min Huang and Mei Huang and Ling Liu and Fang Yang and Chen He and Yu-Chen Sun and Yu-Rui Jiao and Xiang Tang and Jing Hou and Kai-Xuan Chen and Wen-Zhen He and Jie Wei and Hui-Ling Chen and Xia Li and Chao Zeng and Guang-Hua Lei and Chang-Jun Li}, doi = {10.1002/advs.202502634}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2502634}, shortjournal = {Adv. Sci.}, title = {Gut microbiota modulates obesity-associated skeletal deterioration through macrophage aging and grancalcin secretion}, volume = {12}, year = {2025}, }
• (2025). Accelerate mass transport of proton and carbon sources by super-hygroscopic and porous nanosheets for continuous CO2-to-ethylene upgrade. ADVS, 12(28), 2502306. (www)

  @article{ , abstract = {Gas-water/catalyst triple-phase interface and the microenvironment play critical roles in the reaction kinetics and production rate of electrochemical carbon dioxide reduction reactions (CO 2 RR), which steer concerted proton-electron transfer steps. Inspired by Tillandsia leaves, which efficiently capture H 2 O and CO 2 from the air, copper nanosheets with dual-functional channels are we designed: the superhygroscopic network enables capillary condensation, converting H 2 O(g) into H 2 O(l) to form H 2 O channels that ensure a stable supply of protons, while the CO 2 channels formed by the microporous structure enhance the diffusion of CO 2 , thus enriching the carbon source. This synergistic design creates an optimal microenvironment for CO 2 conversion by simultaneously delivering both protons and CO 2 to the reaction interface. Time-of-flight secondary-ion mass spectroscopy (TOF-SIMS), X-ray absorption spectroscopy (XAS) and multiphysics simulations further reveal the designed H 2 O and CO 2 channels in the microenvironment to boost mass transports. Hence, the Faradaic efficiency (FE) for ethylene reaches up to 96% at -200 mA cm −2 with such localized triple-phase interfaces, which simultaneously exhibits ultra-high stability for over 170 h in the membrane electrode assembly (MEA) system. This strategy provides a construction methodology of H 2 O and CO 2 channels for improving the selectivity and stability of electrochemical CO 2 upgrades.}, archive = {J_ADVS}, author = {Silong Dong and Guobin Wen and Xinyu Yang and Xiaowen Zhang and Shuxuan Liu and Haoyang Xiong and Yinyi Liu and Kai Zong and Hao Li and Yifan Li and Yi Cui and Bohua Ren and Xin Wang and Mingliang Jin and Zhongwei Chen}, doi = {10.1002/advs.202502306}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2502306}, shortjournal = {Adv. Sci.}, title = {Accelerate mass transport of proton and carbon sources by super-hygroscopic and porous nanosheets for continuous CO2-to-ethylene upgrade}, volume = {12}, year = {2025}, }
• (2025). Multi-wavelength achromatic 3D meta-holography with zoom function. ADVS, 12(28), 2501881. (www)

  @article{ , abstract = {With the development of nanofabrication technology, meta-holography has shown unprecedented potential for light regulation. However, due to the wavelength mismatch, chromatic aberrations are inevitable in multi-wavelength meta-holography. Moreover, since the meta-hologram is difficult to refresh, zoom meta-holography has not been reported to date. Here, a multi-wavelength achromatic 3D meta-holography with a zoom function is developed, breaking through both the chromatic aberration interference and imaging limit for the first time. A wide-band 3D meta-hologram is generated and is used to design a wide-band metasurface fabricated with nanostructures based on the Pancharatnam–Berry phase, thus achieving the multi-wavelength meta-holography. A fast-tunable liquid lens with a large zoom range is designed, where a high elasticity polymer membrane and a high refractive index composite liquid with suitable viscosity and density are prepared to overcome the bottlenecks of limited zoom range and response speed. By jointly controlling the two liquid lenses, multi-wavelength achromatic 3D meta-holographic images with adjustable depth and size are successfully reconstructed. The zoom ratio of the meta-holographic images can reach 2.1, and the zoom response time can reach 5 ms. Such a tunable multi-wavelength achromatic 3D meta-holography has broad applications in storage, display, and information security.}, archive = {J_ADVS}, author = {Chao Liu and Yi Zheng and Di Wang and Qian Huang and Xiao-Wei Li and Fan-Chuan Lin and You-Ran Zhao and Yi-Wei Zheng and Xiao-Ke Lu and Xin-Ru Li and Xin-Ru Zheng and Xin Xie and Kun Song and Zhen-Fei Li and Wei Lu and Din Ping Tsai and Ruo-Nan Ji and Qiong-Hua Wang}, doi = {10.1002/advs.202501881}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2501881}, shortjournal = {Adv. Sci.}, title = {Multi-wavelength achromatic 3D meta-holography with zoom function}, volume = {12}, year = {2025}, }
• (2025). The SlDOF9-SlSWEET17 module: A switch for controlling sugar distribution between nematode induced galls and roots in tomato. ADVS, 12(28), 2501771. (www)

  @article{ , abstract = {In the complex interactions between plants and pathogens, the regulation of nutrient allocation plays a critical role in determining plant health and susceptibility to diseases. Root-knot nematodes (RKNs, Meloidogyne incognita ) extract sugar from plants during their interactions with the hosts. SWEET (Sugars Will Eventually be Exported Transporters) proteins are a class of non-energy-consuming sugar uniporters that regulate the allocation of sugars in plant. Here, it is find that SlSWEET17 ( Solanum lycopersicum SWEET17), a member of the SWEET family in tomato, is localized to the plasma membrane, Golgi body and small vacuoles, and is highly expressed in galls. Further studies show that SlSWEET17 negatively regulates the sugar transport capacity of other SlSWEETs via protein interactions. Overexpression of SlSWEET17 significantly decreases the soluble sugar content in galls and susceptibility to RKNs, while SlSWEET17 knockout-mutation (ko-mutation) has the opposite effect. It is also identified SlDOF9 ( Solanum lycopersicum DNA binding with one finger 9), an upstream negative regulator of SlSWEET17, using ChIP (chromatin immunoprecipitation) analysis, electrophoretic mobility shift assays and dual-Luciferase assays. SlDOF9- overexpressing plants show increased sugar content in galls and susceptibility to RKNs, and sl dof9 cr ko-mutants have the opposite phenotype. This results show how SlDOF9-SlSWEET17 affects RKN infection through sugar partitioning from roots to galls.}, archive = {J_ADVS}, author = {Xiaoyun Wang and Zhimei Wang and Xinyue Tang and Jiamei Qin and Xiaoxuan Zhou and Lixia Gu and Huihui Bian and Lulu Sun and Huang Huang and Rui Yang and Jianli Wang and Shaohui Wang and Shuangchen Chen and Zhongren Yang and Wenchao Zhao}, doi = {10.1002/advs.202501771}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2501771}, shortjournal = {Adv. Sci.}, title = {The SlDOF9-SlSWEET17 module: A switch for controlling sugar distribution between nematode induced galls and roots in tomato}, volume = {12}, year = {2025}, }
• (2025). Potential-driven dynamic spring-effect of Pd─Cu dual-atoms empowered stability and activity for electrocatalytic reduction. ADVS, 12(28), 2501393. (www)

  @article{ , abstract = {Atomic-level catalysts are extensively applied in heterogeneous catalysis fields. However, it is a general but ineluctable issue that active metal atoms may migrate, aggregate, deactivate, or leach during reaction processes, suppressing their catalytic performances. Designing superior intrinsic-structural stability of atomic-level catalysts with high activity and revealing their dynamic structure evolution is vital for their wide applications in complex reactions or harsh conditions. Herein, high-stable Pd─Cu dual-atom catalysts with PdN 3 ─CuN 3 coordination structure are engineered via strong chelation of Cu 2+ -ions with electron pairs from palladium-source, achieving the highest turnover frequency under the lowest overpotential for Cr(VI) electrocatalytic reduction detection in strong-acid electrolytes. In situ X-ray absorption fine structure spectra reveal dynamic “spring-effect” of Cu─Pd and Cu─N bonds that are reversibly stretched with potential changes and can be recovered at 0.6 V for regeneration. The modulated electron-orbit coupling effect of Pd─Cu pairs prevents Cu-atoms from aggregating as metallic nanoparticles. Pd─Cu dual-atoms interact with two O atoms of H 2 CrO 4 , forming stable bridge configurations and transferring electrons to promote Cr─O bond dissociation, which prominently decreases reaction energy barriers. This work provides a feasible route to boost the stability and robustness of metal single-atoms that are easily affected by reaction conditions for sustainable catalytic applications.}, archive = {J_ADVS}, author = {Pei-Hua Li and Yuan-Fan Yang and Zong-Yin Song and Bo Liang and Yong-Huan Zhao and Xin Cai and Zi-Hao Liu and Jing-Yi Lin and Meng Yang and Xiangyu Xiao and Jing Zhang and Wen-Qing Liu and Xing-Jiu Huang}, doi = {10.1002/advs.202501393}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2501393}, shortjournal = {Adv. Sci.}, title = {Potential-driven dynamic spring-effect of Pd─Cu dual-atoms empowered stability and activity for electrocatalytic reduction}, volume = {12}, year = {2025}, }
• (2025). Pushing the frontiers: Artificial intelligence (AI)-guided programmable concepts in binary self-assembly of colloidal nanoparticles. ADVS, 12(28), 2501000. (www)

  @article{ , abstract = {Colloidal nanoparticle self-assembly is a key area in nanomaterials science, renowned for its ability to design metamaterials with tailored functionalities through a bottom-up approach. Over the past three decades, advancements in nanoparticle synthesis and assembly control methods have propelled the transition from single-component to binary assemblies. While binary assembly has been recognized as a significant concept in materials design, its potential for intelligent and customized assembly has often been overlooked. It is argued that the future trend in the assembly of binary nanocrystalline superlattices (BNLSs) can be analogous to the ‘0s’ and ‘1s’ in computer programming, and customizing their assembly through precise control of these basic units could significantly expand their application scope. This review briefly recaps the developmental trajectory of nanoparticle assembly, tracing its evolution from simple single-component assemblies to complex binary co-assemblies and the unique property changes they induce. Of particular significance, this review explores the future prospects of binary co-assembly, viewed through the lens of ‘AI-guided programmable assembly’. Such an approach has the potential to shift the paradigm from passive assembly to active, intelligent design, leading to the creation of new materials with disruptive properties and functionalities and driving profound changes across multiple high-tech fields.}, archive = {J_ADVS}, author = {Cancan Li and Lindong Ma and Zhenjie Xue and Xiao Li and Shan Zhu and Tie Wang}, doi = {10.1002/advs.202501000}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2501000}, shortjournal = {Adv. Sci.}, title = {Pushing the frontiers: Artificial intelligence (AI)-guided programmable concepts in binary self-assembly of colloidal nanoparticles}, volume = {12}, year = {2025}, }
• (2025). Photo-rechargeable organic supercapacitor via light-activated electrolytes. ADVS, 12(28), 2500978. (www)

  @article{ , abstract = {Light-mediated energy storage is key in diverse applications, including photonic devices, solar energy harvest, and others. Here, we demonstrate the construction of a photo-rechargeable supercapacitor, in which light-induced recharging is based, for the first time, on photoactive labile electrolytes. Specifically, the supercapacitor dielectric medium consisted of 2-nitrobenzaldehyde as the electrolyte. In the dark, 2-nitrobenzaldehyde is not ionized and the device displayed low capacitance. However, upon light irradiation, 2-nitrobenzaldehyde undergoes chemical transformation and forms labile benzoic acid derivatives. These photoacids further ionize upon illumination, with the redox-active photoinduced ionic species giving rise to significantly enhanced capacitance. Importantly, the generation of photoinduced electrolytes is reversible, facilitating multiple charge–discharge cycles. The photo-rechargeable device exhibited extended discharge times, high specific capacitance, capacitance retention, and cyclic stability. The use of the photo-rechargeable supercapacitor is demonstrated for practical charging and powering an external load. Light-induced energy storage mediated by photoactive electrolytes is a new and powerful concept and may open new avenues for photo-charged devices, solar energy harvesting, and storage.}, archive = {J_ADVS}, author = {Shubhra Kanti Bhaumik and Sudipta Biswas and Nitzan Shauloff and Ahiud Morag and Raz Jelinek}, doi = {10.1002/advs.202500978}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2500978}, shortjournal = {Adv. Sci.}, title = {Photo-rechargeable organic supercapacitor via light-activated electrolytes}, volume = {12}, year = {2025}, }
• (2025). A dual approach with organoid and CRISPR screening reveals ERCC6 as a determinant of cisplatin resistance in osteosarcoma. ADVS, 12(28), 2500632. (www)

  @article{ , abstract = {Osteosarcoma (OS), the most prevalent primary bone malignancy in adolescents, is typically treated with cisplatin-based chemotherapy. However, the development of cisplatin resistance often leads to relapse or metastasis, significantly impairing therapeutic efficacy. To tackle this issue, patient-derived osteosarcoma organoids (OSOs) is established that accurately reflect the cellular composition and heterogeneity of the original tumors, as validated by single-cell RNA sequencing, bulk RNA sequencing, and histopathology analysis. Cisplatin resistance is successfully induced in these OSOs, creating a clinically relevant model for investigating chemoresistance. Utilizing RNA sequencing in cisplatin-resistance OSOs and CRISPR screening in OS cell line, ERCC6 is identified as a pivotal regulator of cisplatin resistance. Knockdown of ERCC6 markedly enhanced cisplatin sensitivity in vitro and in vivo. Mechanistically, ERCC6 interacts with HNRNPM, influencing the PI3K/AKT signaling pathway and alternative splicing of pre-mRNA for BAX . Notably, the knockdown of ERCC6 and HNRNPM increased expression of full-length BAX and reduced skipping of exon 2, thus promoting apoptosis. This exon skipping in BAX results in a frameshift and introduces a premature stop codon (TGA) within the BH3 domain. These findings underscore the utility of OSOs in elucidating resistance mechanisms and highlight ERCC6 and HNRNPM as potential therapeutic targets.}, archive = {J_ADVS}, author = {Ruiling Xu and Sai Zhu and Wenchao Zhang and Haodong Xu and Chao Tu and Honghui Wang and Lu Wang and Na He and Tang Liu and Xiaoning Guo and Xiaolei Ren and Zhihong Li}, doi = {10.1002/advs.202500632}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2500632}, shortjournal = {Adv. Sci.}, title = {A dual approach with organoid and CRISPR screening reveals ERCC6 as a determinant of cisplatin resistance in osteosarcoma}, volume = {12}, year = {2025}, }
• (2025). Spatiotemporal regulation of STING activity by linear ubiquitination governs antiviral immunity. ADVS, 12(28), 2417660. (www)

  @article{ , abstract = {The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene protein (STING) signaling plays a critical role in innate immunity and must be tightly regulated to maintain immune homeostasis, but the mechanism underlying the spatiotemporal regulation of this pathway remains largely elusive. Here, it is shown that during DNA viral infection, the linear ubiquitin chain assembly complex (LUBAC) and ovarian tumor deubiquitinase with linear linkage specificity (OTULIN) reversibly catalyze the linear ubiquitination of STING. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus through binding to the Sec24b subunit of the coat protein complex II (COPII) complex. Later on, OTULIN is recruited to TANK1 binding kinase 1 (TBK1)-phosphorylated STING and removes its linear ubiquitin chains, thus preventing excessive antiviral immune responses. Together, the study uncovers a linear ubiquitination-governed spatiotemporal regulatory mechanism that fine-tunes STING-driven antiviral immunity.}, archive = {J_ADVS}, author = {Yong Zhang and Yesheng Fu and Lihua Qiang and Mengyuan Zhao and Zhe Lu and Zhuo Zhao and Guoping Chen and Zehui Lei and Qiyao Chai and Pupu Ge and Bingxi Li and Jing Wang and Cui Hua Liu and Lingqiang Zhang}, doi = {10.1002/advs.202417660}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2417660}, shortjournal = {Adv. Sci.}, title = {Spatiotemporal regulation of STING activity by linear ubiquitination governs antiviral immunity}, volume = {12}, year = {2025}, }
• (2025). Adducin-1 facilitates influenza virus endosomal trafficking and uncoating by regulating branched actin dynamics and myosin IIB activity. ADVS, 12(28), 2417318. (www)

  @article{ , abstract = {Actin- and microtubule-based transport systems are essential for the trafficking of endocytic viruses and cargoes. Microtubules facilitate long-distance transport; however, the precise role of actin dynamics and its regulators during virus entry, particularly in the transit process, remains elusive. Here, Adducin-1 (ADD1) is identified as a key regulator of actin dynamics, as demonstrated by real-time monitoring of quantum dot (QD)-labeled influenza A virus (IAV) movement. ADD1 deletion increases actin density around endocytic vesicles, disrupting general vesicular trafficking and inhibiting the replication of diverse endocytic viruses. Mechanistically, endocytic viruses or cargoes trigger the phosphorylation of ADD1 at Ser726, which reduces the density of actin branches for effective transport. Additionally, the physical force required for IAV capsid dissociation is influenced by ADD1. Collectively, the study identifies a basic actin dynamics event with broad relevance to endocytic viruses or cargo trafficking and represents ADD1 as a potential target for developing broad-spectrum antiviral strategies.}, archive = {J_ADVS}, author = {Meijun Jiang and Jiahui Zou and Yaoming Jin and Chenjun Jiang and Shaoyu Tu and Tong Chen and Jinli Guo and Yanqing Cheng and Meilin Jin and Huanchun Chen and Hongbo Zhou}, doi = {10.1002/advs.202417318}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2417318}, shortjournal = {Adv. Sci.}, title = {Adducin-1 facilitates influenza virus endosomal trafficking and uncoating by regulating branched actin dynamics and myosin IIB activity}, volume = {12}, year = {2025}, }
• (2025). Boosting electronic properties of CsPbBr3 nanocrystals via lithium-ion doping and surface passivation for enhanced electrical conductivity and efficient white light-emitting diodes. ADVS, 12(28), 2417304. (www)

  @article{ , abstract = {Lithium's interaction with CsPbBr 3 nanocrystals (NCs), can enhancing its intrinsic electrical conductivity (σ) for high-performance device applications. Herein, two distinctly different modes of Li⁺ interaction with CsPbBr 3 NCs: minor lattice insertion (0.07% relative to Cs) and predominant surface passivation is reported through Li m Pb n alloy formation. In contrast, Li⁺ exhibits significantly reduced interaction with Cs 4 PbBr 6 NCs, which could be due to the persence of lower amount of Pb 2+ on the surface of these structures. The σ of CsPbBr 3 : x Li + NCs through bottom-contact devices exhibited a gradual increase from 2.1 × 10 −7 to as high as 2.5 × 10 −6 S m −1 , which is a 50-fold improvement compared to CsPbBr 3 NCs. The enhanced σ is attributed to the presence of Li + doping and surface passivation of CsPbBr 3 by the Li m Pb n ligated complexes. DFT calculations revealed electron movement from the valence and to conduction band and a reduced bandgap further supporting the inferences from experimental studies. The unique feature of the increased luminescence and σ of CsPbBr 3 :Li + NCs is explored for fabricating white light emitting diodes. The luminescence efficacy of the device is in the range of 88.5 to 112.5 lm W −1 which is higher compared to pure CsPbBr 3 NCs (96.5 lm W −1 ), offering a pathway for advanced optoelectronic applications.}, archive = {J_ADVS}, author = {Zhongsheng Ge and Siyuan Wan and Muhammad Moin and Sk Abdul Moyez and Lizhuang Dong and Hamood ur Rehman Haris and Marek Piotrowski and Zhiming Wang and Tim Leydecker and Udayabhaskararao Thumu}, doi = {10.1002/advs.202417304}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2417304}, shortjournal = {Adv. Sci.}, title = {Boosting electronic properties of CsPbBr3 nanocrystals via lithium-ion doping and surface passivation for enhanced electrical conductivity and efficient white light-emitting diodes}, volume = {12}, year = {2025}, }
• (2025). Synchrotron radiation-based tomography of an entire mouse brain with sub-micron voxels: Augmenting interactive brain atlases with terabyte data. ADVS, 12(28), 2416879. (www)

  @article{ , abstract = {Synchrotron radiation-based X-ray microtomography is uniquely suited for post-mortem 3D visualization of organs such as the mouse brain. Tomographic imaging of the entire mouse brain with isotropic cellular resolution requires an extended field-of-view and produces datasets of multiple terabytes in size. These data must be reconstructed, analyzed, and made accessible to domain experts who may have limited image processing knowledge. Extended-field X-ray microtomography is presented with voxel size covering an entire mouse brain. The 4495 projections from 8 × 8 offset acquisitions are stitched to reconstruct a volume of 15000 3 voxels. The microtomography volume was non-rigidly registered to the Allen Mouse Brain Common Coordinate Framework v3 based on a combination of image intensity and landmark pairs. The data were block-wise transformed and stored in a public repository with a hierarchical format for navigation and overlay with anatomical annotations in online viewers such as Neuroglancer or siibra-explorer . This study demonstrates X-ray imaging and data processing for a full mouse brain, augmenting current atlases by improving resolution in the third dimension by an order of magnitude. The 3.3-teravoxel dataset is publicly available and easily accessible for domain experts via browser-based viewers.}, archive = {J_ADVS}, author = {Mattia Humbel and Christine Tanner and Marta Girona Alarcón and Georg Schulz and Timm Weitkamp and Mario Scheel and Vartan Kurtcuoglu and Bert Müller and Griffin Rodgers}, doi = {10.1002/advs.202416879}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2416879}, shortjournal = {Adv. Sci.}, title = {Synchrotron radiation-based tomography of an entire mouse brain with sub-micron voxels: Augmenting interactive brain atlases with terabyte data}, volume = {12}, year = {2025}, }
• (2025). A cross-linked flexible metaferroelectrolyte regulated by 2D/2D perovskite heterostructures for high-performance compact solid-state sodium batteries. ADVS, 12(28), 2416662. (www)

  @article{ , abstract = {To address the issues of limited ionic conductivity and poor interface stability at room and low temperatures in solid-state electrolytes, a robust intrinsic ferroelectrolyte or nanoferroelectrolyte strategy for engineering solid-state flexible ferroelectric composite electrolytes utilizing strongly coupled intrinsic ion conducting 2D/2D sodium-rich anti-perovskite (NaRAP)/ferroelectric perovskite heterostructures is introduced. Herein, highly scalable PVDF-based metaferroelectrolytes with Na 2.99 Ba 0.005 OCl/Ca 2 Na 2 Nb 5 O 16 − (CNNO − ) nanosheets into a ferroelectric poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) matrix, through an in situ cross-linking and spontaneous bridging method, for compact solid-state sodium batteries (SSBs), are reported. Benefiting from unique well-dispersed 3D ferroelectric coupled network and the Na 2.99 Ba 0.005 OCl/CNNO − -induced PVDF-HFP ferroelectric β phase, the Na + flux is regulated, thereby inhibiting Na dendrite growth at the interface. Notably, the optimized PH-5% NC metaferroelectrolyte exhibits rapid ion transport (1.11 × 10 −4 S cm −1 at 25 °C), a wide electrochemical window (> 4.8V), superior conformal mechanical compatibility, improved flexibility, good elasticity and flame retardancy. The solid-state Na 3 V 2 (PO 4 ) 3 /PH-5% NC/Na batteries present a stable cycling performance (remaining 56.4 mAh g −1 after 500 cycles at 1 C) even at 0 °C, potential for cost-effective, safe, stable and compact SSB energy storage over 600 Wh L −1 , vastly surpassing 365 Wh L −1 of the current commercial sodium-ion liquid-electrolyte batteries.}, archive = {J_ADVS}, author = {Yanan Huang and Zhuo Yang and Weicheng Zhou and Liequan Liu and Chuanbao Tu and Mingyang Tang and Haijiao Xie and Yu Lu and Xu Yan and Zhihao Ding and Xiaolong Li and Tiannan Yang and Alexander S. Sigov and Wei Huang and Lijun Gao and Cheng Huang}, doi = {10.1002/advs.202416662}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2416662}, shortjournal = {Adv. Sci.}, title = {A cross-linked flexible metaferroelectrolyte regulated by 2D/2D perovskite heterostructures for high-performance compact solid-state sodium batteries}, volume = {12}, year = {2025}, }
• (2025). M2 macrophage-derived extracellular vesicles reprogram immature neutrophils into anxa1hi neutrophils to enhance inflamed bone regeneration. ADVS, 12(28), 2416159. (www)

  @article{ , abstract = {Periodontitis is a microbiome-related inflammation that can lead to irreversible bone reduction and even tooth loss. This study reveals that macrophage polarization states significantly influence periodontal homeostasis, with M2 macrophage-derived extracellular vesicles (M2-EVs) playing a pivotal role in mitigating periodontitis-induced bone loss. Single-cell RNA sequencing of periodontal tissues treated with M2-EVs uncovered a unique Anxa1 hi neutrophil subpopulation exhibiting pro-reparative properties. This subpopulation is characterized by immaturity and demonstrated osteogenic and angiogenic capabilities in vivo, partially mediated through the secretion of oncostatin M (OSM) signals. The findings suggest that this functional heterogeneity arises from M2-EVs disrupting the neutrophil maturation trajectory, with pivotal reprogramming genes, such as Acvrl1 and Fpr2 , driving the differentiation of the Anxa1 hi reparative subpopulation. This work underscores the potential of targeting M2 macrophage-neutrophil interactions to promote the regeneration of inflamed bone tissues.}, archive = {J_ADVS}, author = {Yufei Yao and Yijia Yin and Fangyuan Shuai and Waishan Lam and Tao Zhou and Yaxin Xie and Xuesong He and Xianglong Han}, doi = {10.1002/advs.202416159}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2416159}, shortjournal = {Adv. Sci.}, title = {M2 macrophage-derived extracellular vesicles reprogram immature neutrophils into anxa1hi neutrophils to enhance inflamed bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Inverse design of highly deformable mechanical metamaterial based on partitional semi-random optimization. ADVS, 12(28), 2415935. (www)

  @article{ , abstract = {The flexible mechanical metamaterial leverages the reversible large deformation of its lattice unit cells to transfer force, motion, and energy. This characteristic imparts significant mechanical advantages for both morphological and functional regulation. However, most existing topology optimization methods primarily focus on initial stiffness and degrees of freedom under small deformations, which are incapable of the customization of large deformations in mechanical metamaterials. In this research, the concept of partitional semi-random optimization is proposed, which respectively records the structural evolution history in each subregion and evaluates the value. The new concept involves a statistical decision-making procedure, which avoids the repetitive iterations in traditional completely random heuristic optimizations. In addition, a two-step optimization scheme for local stiffness regulation is developed to expand the design space of one single material. This method facilitates the personalized customization of both the multi-objective deformation pattern and the deformation path of highly deformable mechanical metamaterial made from homogeneous rubbers. The efficiency of the design process is verified by experiments with 3D-printed metamaterial samples. This research offers a novel solution to the large deformation design of shape-morphing structures and soft robotics.}, archive = {J_ADVS}, author = {Xueqing Cao and Zeang Zhao and Panding Wang and Shengyu Duan and Hongshuai Lei}, doi = {10.1002/advs.202415935}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2415935}, shortjournal = {Adv. Sci.}, title = {Inverse design of highly deformable mechanical metamaterial based on partitional semi-random optimization}, volume = {12}, year = {2025}, }
• (2025). Self-adaptive reflectance film for passive temperature regulation in diverse environments. ADVS, 12(28), 2415121. (www)

  @article{ , abstract = {Passive thermal-regulation strategies have become increasingly important due to the strain alleviated on power grids for temperature management. Designing a system capable of automatically switching between cooling and heating modes in response to changing ambient conditions presents several specific challenges that engineers and researchers are actively addressing. In this research, a CaCl 2 incorporated PNIPAM coated fluorinated poly(aryl ether) (FPAE) porous film with tunable reflectance is developed. The aim is to mitigate the reliance on active cooling systems, which consume significant amounts of energy. The moisture-temperature dual sensitive film exhibits a tunable reflectance range between 91.1% and 39.1% via phase change of the PNIPAM layer. Coupled with an infrared emissivity of 96.0%, a daytime cooling of 10 °C compared to the control experiment is achieved. Coating the film with a photothermal layer results in an adaptive Janus film that is capable of autonomous switching between heating and cooling, and demonstrates a heating of 22.5 °C in a cold environment. The facile preparation method, excellent cyclic stability, mechanical properties, and UL-94 V-0 rating enable promising applications of the smart film under diverse living environments.}, archive = {J_ADVS}, author = {Shuo Yang and Sizhe Tang and Yufeng Cai and Zhiming Ye and Xiangbin Zou and Xueyu Yuan and Yujie Song and Bing Li and Dongyan Tang and Ming Liu}, doi = {10.1002/advs.202415121}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2415121}, shortjournal = {Adv. Sci.}, title = {Self-adaptive reflectance film for passive temperature regulation in diverse environments}, volume = {12}, year = {2025}, }
• (2025). Nanoscale curvature regulates YAP/TAZ nuclear localization through nuclear deformation and rupture. ADVS, 12(28), 2415029. (www)

  @article{ , abstract = {Nuclear translocation of the transcription regulatory proteins yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) is a critical readout of cellular mechanotransduction. Recent experiments have demonstrated that cells on substrates with well-defined nanotopographies demonstrate mechanoadaptation through a multitude of effects - increased integrin endocytosis as a function of nanopillar curvature, increased local actin assembly on nanopillars but decreased global cytoskeletal stiffness, and enhanced nuclear deformation. How do cells respond to local nanotopographical cues and integrate their responses across multiple length scales? This question is addressed using a biophysical model that incorporates plasma membrane (PM) curvature-dependent endocytosis, PM curvature-sensitive actin assembly, and stretch-induced opening of nuclear pore complexes (NPCs) in the nuclear envelope (NE). This model recapitulates lower levels of global cytoskeletal assembly on nanopillar substrates, which can be partially compensated for by local actin assembly and NE indentation, leading to enhanced YAP/TAZ transport through stretched NPCs. Using cell shapes informed by electron micrographs and fluorescence images, the model predicts lamin A and F-actin localization around nanopillars, in agreement with experimental measurements. Finally, simulations predict nuclear accumulation of YAP/TAZ following rupture of the NE and this is validated by experiments. Overall, this study indicates that nanotopography tunes mechanoadaptation through both positive and negative feedback on mechanotransduction.}, archive = {J_ADVS}, author = {Emmet A. Francis and Einollah Sarikhani and Vrund Patel and Dhivya Pushpa Meganathan and Leah Sadr and Anum Tahir and Zeinab Jahed and Padmini Rangamani}, doi = {10.1002/advs.202415029}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2415029}, shortjournal = {Adv. Sci.}, title = {Nanoscale curvature regulates YAP/TAZ nuclear localization through nuclear deformation and rupture}, volume = {12}, year = {2025}, }
• (2025). DNA-PKcs-driven YAP1 phosphorylation and nuclear translocation: A key regulator of ferroptosis in hyperglycemia-induced cardiac dysfunction in type 1 diabetes. ADVS, 12(28), 2412698. (www)

  @article{ , abstract = {The DNA-Dependent Protein Kinase catalytic subunit (DNA-PKcs) acts as a principal executor in the DNA damage response (DDR), mediating the phosphorylation of a broad spectrum of substrates integral to DNA repair and apoptosis. This investigation seeks to discern the possible association and mechanisms linking hyperglycemia-induced ferroptosis and DNA-PKcs in DCM. This data exhibits a substantial activation of DNAPKcs- dependent DDR in mice with streptozotocin-induced DCM. However, deletion of DNA-PKcs in cardiomyocytes notably mitigates DNA damage, enhances heart function and dampens the inflammatory response. Co-IP/MS analysis and subsequent validation experiments demonstrate that DNA-PKcs directly interacts with and phosphorylates YAP1 at Thr226. This phosphorylation event facilitates the nuclear retention of YAP1, where it intensifies the transcription of ferroptosis-associated genes. Knockin mice expressing a nonphosphorylatable T226A YAP1 mutant display decreased ferroptosis, reduced myocardial fibrosis and improved heart function. Taken together, this study unravels that DDR acts as an intracellular stress damage sensor, perceiving hyperglycemic conditions and subsequently transmitting the damage signal to incite ferroptosis through the interplay between DNA-PKcs and YAP1. This novel insight suggests that the DNA-PKcs-mediated YAP1 phosphorylation and the ferroptosis activation could be the promising therapeutic targets for the management of DCM.}, archive = {J_ADVS}, author = {Junyan Wang and Xing Chang and Chun Li and Jing Gao and Zhijiang Guo and Haowen Zhuang and Lingjun Wang and Yusheng Huang and Wei Wang and Chao Li and Qingyong He}, doi = {10.1002/advs.202412698}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2412698}, shortjournal = {Adv. Sci.}, title = {DNA-PKcs-driven YAP1 phosphorylation and nuclear translocation: A key regulator of ferroptosis in hyperglycemia-induced cardiac dysfunction in type 1 diabetes}, volume = {12}, year = {2025}, }
• (2025). Quantitative super-resolution imaging of molecular tension. ADVS, 12(28), 2408280. (www)

  @article{ , abstract = {DNA-based molecular tension probes have revolutionized the localization of mechanical events in live cells with super-resolution. However, imaging the magnitude of these forces at super-resolution has been challenging. Here, qtPAINT (quantitative tension points accumulation for imaging in nanoscale topography) is introduced as a strategy to image the magnitude of molecular tension with super-resolution accuracy. By leveraging the force-dependent dissociation kinetics of short DNA oligonucleotides on their complementary strands, tension is encoded on individual molecules through their binding kinetics. This method allowed for a quantitative analysis of these kinetics, providing a detailed reconstruction of the force magnitudes acting on each tension probe. The technique integrates a molecular-beacon PAINT imager with a hairpin molecular tension probe, achieving a force quantification range of 9–30 pN and maintaining a spatial resolution of 30–120 nm in low and high-density regions. Additionally, qtPAINT offers a temporal resolution on the order of a minute, enhancing its applicability for studying dynamic cellular processes.}, archive = {J_ADVS}, author = {Seong Ho Kim and Adam B. Yasunaga and Hongyuan Zhang and Kevin D. Whitley and Isaac T. S. Li}, doi = {10.1002/advs.202408280}, journal = {Advanced Science}, month = {7}, number = {28}, pages = {2408280}, shortjournal = {Adv. Sci.}, title = {Quantitative super-resolution imaging of molecular tension}, volume = {12}, year = {2025}, }
• (2025). Dual-locking the SARS-CoV-2 spike trimer: An amphipathic molecular “Bolt” stabilizes conserved druggable interfaces for coronavirus inhibition (Adv. sci. 27/2025). ADVS, 12(27), 2570215. (www)

  @article{ , archive = {J_ADVS}, author = {Shiliang Li and Fang Ye and Yucheng Zheng and Jie Wang and Haoran Peng and Lili Zhu and Lili Chen and Tao Yu and Huan Ge and Jiaqi He and Binghao Zhang and Jiayun Wu and Zhiyi Zhang and Liangliang Jiang and Geng Chen and Ping Zhao and Ke Lan and Zhenjiang Zhao and Xuhong Qian and Ke Xu and Yang Du and Honglin Li}, doi = {10.1002/advs.202570215}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2570215}, shortjournal = {Adv. Sci.}, title = {Dual-locking the SARS-CoV-2 spike trimer: An amphipathic molecular “Bolt” stabilizes conserved druggable interfaces for coronavirus inhibition (Adv. sci. 27/2025)}, volume = {12}, year = {2025}, }
• (2025). Localized sound-integrated display speaker using crosstalk-free piezoelectric vibration array (Adv. sci. 27/2025). ADVS, 12(27), 2570214. (www)

  @article{ , archive = {J_ADVS}, author = {Inpyo Hong and Su Seok Choi}, doi = {10.1002/advs.202570214}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2570214}, shortjournal = {Adv. Sci.}, title = {Localized sound-integrated display speaker using crosstalk-free piezoelectric vibration array (Adv. sci. 27/2025)}, volume = {12}, year = {2025}, }
• (2025). Self-maintainable electronic materials with skin-like characteristics enabled by graphene-PEDOT:PSS fillers (Adv. sci. 27/2025). ADVS, 12(27), 2570213. (www)

  @article{ , archive = {J_ADVS}, author = {Morteza Alehosseini and Firoz Babu Kadumudi and Sinziana Revesz and Parham Karimi Reikandeh and Jonas Rosager Henriksen and Tiberiu-Gabriel Zsurzsan and Jon Spangenberg and Alireza Dolatshahi-Pirouz}, doi = {10.1002/advs.202570213}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2570213}, shortjournal = {Adv. Sci.}, title = {Self-maintainable electronic materials with skin-like characteristics enabled by graphene-PEDOT:PSS fillers (Adv. sci. 27/2025)}, volume = {12}, year = {2025}, }
• (2025). Inherited nitrogen distribution control in covalent organic framework cathodes for efficient electrochemical lithium recovery via capacitive deionization (Adv. sci. 27/2025). ADVS, 12(27), 2570212. (www)

  @article{ , archive = {J_ADVS}, author = {Rajesh Dhanushkotti and Abdul Khayum Mohammed and Kayaramkodath Chandran Ranjeesh and Hema Mylnahalli Krishnegowda and Najat Maher Aldaqqa and Dinesh Shetty}, doi = {10.1002/advs.202570212}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2570212}, shortjournal = {Adv. Sci.}, title = {Inherited nitrogen distribution control in covalent organic framework cathodes for efficient electrochemical lithium recovery via capacitive deionization (Adv. sci. 27/2025)}, volume = {12}, year = {2025}, }
• (2025). Intraoperative fast adaptive focus tracking robotic OCT enables real-time tumor grading and large-area microvascular imaging in human spinal cord surgery (Adv. sci. 27/2025). ADVS, 12(27), 2570210. (www)

  @article{ , archive = {J_ADVS}, author = {Bin He and Yuzhe Ying and Yejiong Shi and Zhe Meng and Zichen Yin and Zhengyu Chen and Zhangwei Hu and Ruizhi Xue and Linkai Jing and Yang Lu and Zhenxing Sun and Weitao Man and Youtu Wu and Dan Lei and Ning Zhang and Guihuai Wang and Ping Xue}, doi = {10.1002/advs.202570210}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2570210}, shortjournal = {Adv. Sci.}, title = {Intraoperative fast adaptive focus tracking robotic OCT enables real-time tumor grading and large-area microvascular imaging in human spinal cord surgery (Adv. sci. 27/2025)}, volume = {12}, year = {2025}, }
• (2025). Blockchain-empowered H-CPS architecture for smart agriculture (Adv. sci. 27/2025). ADVS, 12(27), 2570209. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaoding Wang and Qibin Wu and Haitao Zeng and Xu Yang and Hui Cui and Xun Yi and Md. Jalil Piran and Ming Luo and Youxiong Que}, doi = {10.1002/advs.202570209}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2570209}, shortjournal = {Adv. Sci.}, title = {Blockchain-empowered H-CPS architecture for smart agriculture (Adv. sci. 27/2025)}, volume = {12}, year = {2025}, }
• (2025). Electrochemical-genetic programming of protein-based magnetic soft robots for active drug delivery (Adv. sci. 27/2025). ADVS, 12(27), 2570208. (www)

  @article{ , archive = {J_ADVS}, author = {Hang Zhao and Bo Yu and Dingyi Yu and Ting Ji and Kexin Nie and Jingyi Tian and Xinchen Shen and Kaiyue Zhang and Junhan Ou and Xinyi Yang and Dongfang Xiao and Qi Zhou and Wenwen Huang}, doi = {10.1002/advs.202570208}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2570208}, shortjournal = {Adv. Sci.}, title = {Electrochemical-genetic programming of protein-based magnetic soft robots for active drug delivery (Adv. sci. 27/2025)}, volume = {12}, year = {2025}, }
• (2025). Oxygen vacancy defect engineering for transverse thermoelectric enhancement: A novel extrinsic pathway beyond intrinsic approaches (Adv. sci. 27/2025). ADVS, 12(27), 2570207. (www)

  @article{ , archive = {J_ADVS}, author = {Min Young Kim and Dongkyu Lee and June Ho Lee and Donghwa Lee and Gi-Yeop Kim and Si-Young Choi and Joseph P. Heremans and Hyungyu Jin}, doi = {10.1002/advs.202570207}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2570207}, shortjournal = {Adv. Sci.}, title = {Oxygen vacancy defect engineering for transverse thermoelectric enhancement: A novel extrinsic pathway beyond intrinsic approaches (Adv. sci. 27/2025)}, volume = {12}, year = {2025}, }
• (2025). Transparent Ceramic@Sapphire composites for high-power laser-driven lighting. ADVS, 12(27), 2505232. (www)

  @article{ , abstract = {Although phosphor ceramics are promising candidates for high-power laser lighting applications, their performance is seriously restricted by luminance saturation effects. This study proposes a novel transparent ceramic@sapphire composite material design, fabricated via a straightforward high-temperature sintering process, which differs from the conventional approach of incorporating high-thermal-conductivity microcrystalline grains. This kind of composite can effectively avoid luminescence grain dilution, and deliver significantly enhanced thermal conductivity (36.9 W·m −1 K −1 ) alongside superior luminescence performance. This strategy demonstrates exceptional versatility across various ceramic systems, delivering luminescence improvements of 152–319% and enhancing luminance saturation thresholds by 100–233%, relative to traditional ceramic converters. Using Lu 2-x CaMg 2 Si 3 O 12 : xCe 3+ @sapphire as a representative example, the optimized composite enables substantial enhancements in luminous flux (5902 lm) and luminous efficacy (148 lm W −1 ) under blue laser excitation. Compared with commercial counterparts, practical applications in automotive headlights further validate the potential of this design, offering far higher luminance intensity, extended illumination distances (> 400 m), and more uniform color distribution. This study provides a scalable and universal strategy for advancing next-generation solid-state lighting.}, archive = {J_ADVS}, author = {Guoyu Xi and Shisheng Lin and Tongjie Shen and Tao Pang and Zikang Yu and Yang Peng and Lingwei Zeng and Yuxiang Ke and Zhehong Zhou and Ronghua Chen and Feng Huang and Daqin Chen}, doi = {10.1002/advs.202505232}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2505232}, shortjournal = {Adv. Sci.}, title = {Transparent Ceramic@Sapphire composites for high-power laser-driven lighting}, volume = {12}, year = {2025}, }
• (2025). Engineered bacterial outer membrane vesicles hitchhiking on neutrophils for antibody drug delivery to enhance postoperative immune checkpoint therapy. ADVS, 12(27), 2505000. (www)

  @article{ , abstract = {In clinical practice, surgical removal of tumors often leaves behind small tumors and circulating tumor cells, increasing the risk of metastasis and recurrence, which seriously affects treatment outcomes. Immunotherapy activates the immune system to monitor and inhibit tumor metastasis and recurrence long-term. However, inflammatory microenvironments at surgical sites lead to immunosuppressive tumor-associated macrophages (TAMs), causing immune evasion. Additionally, tumor cells overexpress the immune checkpoint CD47, further weakening the phagocytic and cytotoxic functions of macrophages. Here, the bacterial outer membrane vesicles (OMV) hitchhiking on neutrophils are utilized to precisely deliver immune checkpoint blockade antibodies to the tumor resection site. Escherichia coli is reprogrammed to express CD47 antibody and used to extract CD47 antibody-containing OMV, followed by insertion of Ce6 photosensitizer into the membrane (OC47-Ce6). Purified autologous neutrophils phagocytose and carry OC47-Ce6 for precise targeting to the postoperative tumor resection site, mediating tumor cell killing, aCD47 release, and tumor-associated antigen presentation by light. In vitro and in vivo experiments demonstrate that OC47-Ce6 enhances TAM phagocytic function through TAM polarization and CD47 blockade. This approach effectively activates T-cell anti-tumor immune responses and significantly reduces the risk of postoperative tumor recurrence and metastasis.}, archive = {J_ADVS}, author = {Meng Guan and Xiao-Ting Xie and Dong Zhou and Kai Cheng and Bin Zhang and Xin-Yue Xu and Yong Li and Yi-Tong Zhou and Wei Peng and Li-Li Chen and Peng-Shuo Dong and Si Chen and Jia-Hua Zou and Bo Liu and Yuan-Di Zhao and Jin-Xuan Fan}, doi = {10.1002/advs.202505000}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2505000}, shortjournal = {Adv. Sci.}, title = {Engineered bacterial outer membrane vesicles hitchhiking on neutrophils for antibody drug delivery to enhance postoperative immune checkpoint therapy}, volume = {12}, year = {2025}, }
• (2025). Transfer learning empowered multiple-indicator optimization design for terahertz quasi-bound state in the continuum biosensors. ADVS, 12(27), 2504855. (www)

  @article{ , abstract = {Terahertz metasurface biosensors based on the quasi-bound state in the continuum (QBIC) offer label-free, rapid, and ultrasensitive biomedical detection. Recent advances in deep learning facilitate efficient, fast, and customized design of such metasurfaces. However, prior approaches primarily establish one-to-one mappings between structure and optical response, neglecting the trade-offs among key performance indicators. This study proposes a pioneering method leveraging transfer learning to optimize multiple indicators in metasurface biosensor design. For the first time, multiple-indicator comprehensive optimization of the quality (Q) factor, figure of merit (FoM), and effective sensing area (ESA) is achieved. The two-stage transfer learning method pre-trains on low-dimensional datasets to extract shared features, followed by fine-tuning on complex, high-dimensional tasks. By adopting frequency shift as a unified criterion, the contribution ratios of these indicators are quantified as 26.09% for the Q factor, 48.42% for FoM, and 25.49% for ESA. Compared to conventional deep-learning approaches, the proposed method reduces data requirements by 50%. The biosensor designed using this method detects the biomarker homocysteine, achieving detection at the ng µL −1 level, with experimental results closely matching theoretical predictions. This work establishes a novel paradigm for metasurface biosensor design, paving the way for transformative advances in trace biological detection.}, archive = {J_ADVS}, author = {Shengfeng Wang and Bingwei Liu and Xu Wu and Zuanming Jin and Yiming Zhu and Linjie Zhang and Yan Peng}, doi = {10.1002/advs.202504855}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2504855}, shortjournal = {Adv. Sci.}, title = {Transfer learning empowered multiple-indicator optimization design for terahertz quasi-bound state in the continuum biosensors}, volume = {12}, year = {2025}, }
• (2025). Functionalized biomimetic nanoparticles targeting the IL-10/IL-10Rα/Glycolytic axis in synovial macrophages alleviate cartilage degeneration in osteoarthritis. ADVS, 12(27), 2504768. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a low-grade inflammatory disease that is highly associated with severe hyperplasia of the synovial membrane and the degeneration of cartilage. Interleukin-10 (IL-10), has been extensively studied, while its receptor, IL-10Rα, has not been widely mentioned in the context of OA. A significant difference is found in the expression of IL-10Rα in synovial macrophages from normal and OA patients, along with a marked increase in the glycolytic activity of synovial macrophages. In IL-10Rα Lysm OA mice, the specific deficiency of IL-10Rα exacerbated the progression of OA. Mechanistically, hypoxia-inducible factor-1α (HIF-1α) is identified as a key transcription factor, and its inhibition significantly weakened the glycolytic process. Additionally, differences in ferroptosis of chondrocytes are observed. After co-culturing the two types of cells in vitro, a significant connection is found between the glycolytic state of synovial macrophages and the ferroptosis of chondrocytes. To achieve targeted therapy, MI@UN, a biomimetic nanoparticle encapsulating NO-prednisolone in UIO-66-NH 2 , surface-modified with IL-10, and coated with macrophage membranes (MM), is developed. It significantly slows osteoarthritis progression in mice. This offers new insights into OA pathogenesis, highlighting IL-10Rα as a therapeutic target and supporting MI@UN's translational use for OA treatment.}, archive = {J_ADVS}, author = {Wenwei Li and Yang Liu and Ming Wei and Zhichao Yang and Zhaoyu Li and Zezhong Guo and Liang Yan and Yang Lu and Hao Tang and Bofeng Li and Wei Huang}, doi = {10.1002/advs.202504768}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2504768}, shortjournal = {Adv. Sci.}, title = {Functionalized biomimetic nanoparticles targeting the IL-10/IL-10Rα/Glycolytic axis in synovial macrophages alleviate cartilage degeneration in osteoarthritis}, volume = {12}, year = {2025}, }
• (2025). Constructing palladium-based Crystalline@Amorphous Core–Shell heterojunctions for efficient formic acid oxidation. ADVS, 12(27), 2504469. (www)

  @article{ , abstract = {Constructing crystalline@amorphous heterostructures allows nanomaterials to maintain high electrical conductivity of crystalline structures while acquiring abundant active sites from amorphous structure. This emerging strategy has attracted considerable attention in electrochemical and photoelectrochemistry applications. However, achieving crystalline@amorphous heterostructures based on palladium (Pd) remains challenging due to the difficulties in balancing the transformation between these two phases. Here, a feasible strategy is developed to manufacture Pd-based crystalline@amorphous core–shell structures through non-metallic element doping. The obtained core–shell structures exhibit outstanding catalytic performance for formic acid oxidation (FAO) with mass activity of up to 2.503 A mg −1 Pd . Detailed theoretical and experimental analyses reveal that the construction of crystalline@amorphous core–shell structures increase surface active sites, lowers the oxidation energy barrier, and enhances the selectivity of the direct pathway, thereby effectively facilitating the FAO process. This work demonstrates the feasibility of constructing efficient FAO catalysts using crystalline@amorphous core–shell structures and provides a new platform for achieving platinum-group metals (PGMs) based crystalline-amorphous heterostructures.}, archive = {J_ADVS}, author = {Huiling Li and Jingkun Yu and Yongming Sui and Weibin Wang and Jiewen Liu and LiBo Sheng and Ankang Chen and Siyu Lu and Bo Zou}, doi = {10.1002/advs.202504469}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2504469}, shortjournal = {Adv. Sci.}, title = {Constructing palladium-based Crystalline@Amorphous Core–Shell heterojunctions for efficient formic acid oxidation}, volume = {12}, year = {2025}, }
• (2025). Noble metal nanoparticles anchored on transition metal phosphides for effective pH-universal hydrogen evolution. ADVS, 12(27), 2504462. (www)

  @article{ , abstract = {Constructing electrocatalysts with high activity and low precious metal content is essential for achieving efficient hydrogen production in pH-universal overall water splitting. Herein, five types of noble metal anchored transition metal phosphides are analyzed by theoretical derivation. Based on the calculation results, a suitable hybrid is screened out of Pt nanoparticles anchored on CoP nanowires (Pt─CoP) via robust Pt─P─Co bonds. This strong synergy between Pt and CoP through interfacial Pt─P─Co bonds optimizes the adsorption of key intermediates for hydrogen evolution reaction (HER) in a wide pH range from 0 to 14. Furthermore, strong interaction between Pt and CoP accompanied by a delicate structure reduces interfacial charge transfer resistance, creates abundant active sites, and enhances catalyst durability, while facilitating active site exposure and electron/mass transfer during the HER process. Accordingly, the synthesized Pt─CoP exhibits low overpotentials of 79, 26, and 18 mV at 10 mA cm −2 in acidic, neutral, and alkaline media for HER, respectively, superior to commercial Pt/C benchmarks and most reported electrocatalysts. This work paves a new clue to exploit electrocatalysts with low-Pt-loading for pH-universal HER.}, archive = {J_ADVS}, author = {Hang Lei and Yifan Zhou and Zhuowen Huangfu and Liangjun Chen and Jin Cao and Xuelin Yang and Wenjie Mai and Zilong Wang}, doi = {10.1002/advs.202504462}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2504462}, shortjournal = {Adv. Sci.}, title = {Noble metal nanoparticles anchored on transition metal phosphides for effective pH-universal hydrogen evolution}, volume = {12}, year = {2025}, }
• (2025). Single-cell transcriptome reveals aquaporin-mediated carbon nanosol-induced growth promotion of plants. ADVS, 12(27), 2504459. (www)

  @article{ , abstract = {Carbon nanosol (CNS) is a novel carbon nanomaterial with the potential for enhancing plant growth, yet the underlying mechanism remains unclear. Application of 10 mg L −1 CNS significantly promotes plant growth, increasing fresh mass by 59.51%. Track of fluorescent labeling CNS reveals that it is rapidly absorbed by roots and entered the vascular bundle and cortex within 2 h. A single-cell transcriptomic atlas of tobacco roots response to CNS treatment is generated, which comprises 7,897 cells representing 13 distinct cell types. CNS is found to affect gene expression in a cell type-specific manner, suggesting the heterogeneity of plant response to CNS. Further pseudo-time trajectory analysis reveals that most cell types undergo cell fate transitions toward a more mature state under CNS treatment. In addition, aquaporin proteins NIPs and TIPs are found to be activated and significantly upregulated in epidermal, cortical, and endodermal cells. Further genetic and physiological findings reveal that growth enhance effect of CNS for tip1;1 and tip2;1 mutants is significantly weakened compared to the wild type, indicating that aquaporins play an important role in CNS-mediated plant growth promotion. Overall, these results provide new insights into the mechanism by which CNS promotes plant growth at the single-cell level.}, archive = {J_ADVS}, author = {Lingtong Cheng and Zechao Qu and Qiansi Chen and Lin Wang and Huan Su and Jiemeng Tao and Peng Lu and Taibo Liang and Jianfeng Zhang and Peijian Cao and Jingjing Jin}, doi = {10.1002/advs.202504459}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2504459}, shortjournal = {Adv. Sci.}, title = {Single-cell transcriptome reveals aquaporin-mediated carbon nanosol-induced growth promotion of plants}, volume = {12}, year = {2025}, }
• (2025). Microbial biosensor for sensing and treatment of intestinal inflammation. ADVS, 12(27), 2504364. (www)

  @article{ , abstract = {Synthetic biology has enabled the development of biosensors to detect intestinal inflammation, yet few target the clinically validated biomarker of intestinal inflammation calprotectin with both diagnostic and therapeutic capabilities. Here, an optimized calprotectin biosensor is presented that leverages a zinc uptake regulator (Zur) controlled promoter coupled with a memory circuit to detect and record intestinal inflammation in vivo. The level of biosensor activation strongly correlates with calprotectin levels in the colon of two independent mouse models of colitis. Coupling of the biosensor with the production of the anti-inflammatory cytokine IL10 allowed for the resolution of chemically induced colitis, demonstrating the ability of the biosensor to sense and respond to disease. This work highlights the utility of developing synthetic organisms for the diagnosis and treatment of intestinal disease using clinically validated biomarkers.}, archive = {J_ADVS}, author = {Duolong Zhu and Jeffrey Galley and Jason Pizzini and Elena Musteata and Martin V. Douglas and Walter J. Chazin and Eric P. Skaar and Jeffrey J. Tabor and Robert A. Britton}, doi = {10.1002/advs.202504364}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2504364}, shortjournal = {Adv. Sci.}, title = {Microbial biosensor for sensing and treatment of intestinal inflammation}, volume = {12}, year = {2025}, }
• (2025). Ultrasound-responsive piezoelectric membrane promotes osteoporotic bone regeneration via the “Two-way regulation” bone homeostasis strategy. ADVS, 12(27), 2504293. (www)

  @article{ , abstract = {The repair of osteoporotic bone defects remains inadequately addressed, primarily due to a disruption in bone homeostasis, characterized by insufficient bone formation and excessive bone resorption. Current research either focuses on promoting bone formation or inhibiting bone resorption, however, the bone repair efficacy of these single-target therapeutic strategies is limited. Herein, a “two-way regulation” bone homeostasis strategy is proposed utilizing piezoelectric composite membranes (DAT/KS), capable of simultaneously regulating osteogenesis and osteoclastogenesis, with high piezoelectric performance, good biocompatibility, and excellent degradability, to promote bone regeneration under osteoporotic conditions. The DAT/KS membrane under ultrasound (US) treatment enables the controlled modulation of piezoelectric stimulation and the release of saikosaponin D (SSD), which promotes osteogenic differentiation while simultaneously inhibiting osteoclast differentiation and function, thereby effectively restoring bone homeostasis and enhancing osteoporotic bone repair. Mechanistic insights reveal the promotion of both canonical and non-canonical Wnt signaling in bone marrow mesenchymal stem cells (BMSCs), which determines their osteogenic differentiation fate, and the downregulation of the NF-κB signaling in bone marrow mononuclear macrophages (BMMs). This study presents optimized sono-piezoelectric biomaterials capable of bidirectionally regulating both osteogenic and osteoclastic differentiation, providing a new potential therapeutic approach for pathological bone injuries.}, archive = {J_ADVS}, author = {Xinhui Wu and Tianlong Wang and Jinhui Zhao and Lei Zhang and Zhiqing Liu and Yixing Chen and Yiping Luo and Yaqi Liu and Yan Chen and Hui Jiang and Dilixiati Duolikun and Junjian Liu and Wentao Cao and Longpo Zheng}, doi = {10.1002/advs.202504293}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2504293}, shortjournal = {Adv. Sci.}, title = {Ultrasound-responsive piezoelectric membrane promotes osteoporotic bone regeneration via the “Two-way regulation” bone homeostasis strategy}, volume = {12}, year = {2025}, }
• (2025). M6A-mediated TMCO3 promotes hepatocellular carcinoma progression by facilitating the membrane translocation and activation of AKT. ADVS, 12(27), 2504187. (www)

  @article{ , abstract = {The transmembrane and coiled-coil domains 3 (TMCO3) are highly expressed in many tumors. However, the underlying mechanisms governing the way in which TMCO3 affects the progression of hepatocellular carcinoma (HCC) remain unclear. This study screens out the molecule TMCO3 with high N6-methyladenosine (m 6 A) modification level in tumor samples compared to the adjacent non-cancerous tissues of three pairs of HCC patients through Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq) and RNA sequencing (RNA-seq). Subsequently, the oncogenic effect of TMCO3 in HCC is verified through in vivo and in vitro experiments. AlkB Homolog 5 (ALKBH5), an m 6 A demethylase of TMCO3 is then screened out. The following experiments demonstrate that TMCO3 can activate AKT directly through the Phosphatidylinositol-3–Kinase (PI3K) pathway, thus promoting the progression of HCC. Meanwhile, the phosphorylation site on TMCO3: the 85 th amino acid-serine, and mutation of this site can directly impair the activity and membrane translocation of AKT is found. Finally, the carcinogenic effect of TMCO3 is further elucidated in HCC through the orthotopic treatment model and the hydrodynamic tail vein injection treatment model. The findings can provide a potential target for targeted AKT treatment in patients with HCC and verify a possible prognostic marker in HCC.}, archive = {J_ADVS}, author = {Xinxin Li and Mengzhen Han and He Zhu and Yonglong Pan and Chen Su and Yachong Liu and Zhibin Liao and Bixiang Zhang and Xiaoping Chen}, doi = {10.1002/advs.202504187}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2504187}, shortjournal = {Adv. Sci.}, title = {M6A-mediated TMCO3 promotes hepatocellular carcinoma progression by facilitating the membrane translocation and activation of AKT}, volume = {12}, year = {2025}, }
• (2025). Dual-function ceramic pigments for energy-efficient and secure autonomous vehicles. ADVS, 12(27), 2503901. (www)

  @article{ , abstract = {The global automobile market continues to demonstrate robust growth and innovation potential. Vehicles have evolved into complex, technology-intensive platforms, and autonomous vehicles are anticipated to become commonplace in the near future. However, key challenges persist, such as managing excessive energy consumption and ensuring precise object detection. Under intense sunlight, elevated in-vehicle temperatures lead to higher demand for cooling systems, ultimately increasing energy use. Furthermore, autonomous driving necessitates accurate detection of surrounding vehicles. To address these issues, doped ceramic pigments with diverse colors are developed, exhibiting enhanced near-infrared (NIR) reflectance across the solar spectrum, thereby achieving a radiative cooling (RC) effect. In addition, to improve detectability by LiDAR, scattering analyses are performed to investigate how ceramic particles scatter incident light in various directions. The results indicate that although the scattering is not strictly retro-reflective, it strongly redirects the incident wave back toward its source, which is advantageous for LiDAR-based object detection. Consequently, a bi-function ceramic pigment (BFCP) is fabricated with both superior RC performance and heightened LiDAR detectability compared to commercial pigments. Moreover, integrating BFCP with commercial pigments enables anti-counterfeiting strategies, as letters or patterns invisible to the naked eye can be visualized under IR-mode cameras.}, archive = {J_ADVS}, author = {Ik Hoon Jeong and Yong-Jun Seo and Jum Soo Hwang and Geun Hyeong Kim and Yeong Jae Kim and Gil Ju Lee}, doi = {10.1002/advs.202503901}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503901}, shortjournal = {Adv. Sci.}, title = {Dual-function ceramic pigments for energy-efficient and secure autonomous vehicles}, volume = {12}, year = {2025}, }
• (2025). Multi-dimensional multiplexed metasurface for multifunctional near-field modulation by physics-driven intelligent design. ADVS, 12(27), 2503899. (www)

  @article{ , abstract = {Metasurface is a revolutionary platform to achieve desired properties by artificially engineering meta-atom's arrangements. However, the explosively expanding design space of advanced metasurfaces with multiple degrees of freedom (MDOF) has made the traditional human-guided design methods increasingly ineffective, limiting the development of the metasurfaces. Intelligent design methods have been presented to tackle these challenges by introducing innovative computational models, but they are predominantly data-driven and faced the issues of data scarcity, poor physical interpretability, and weak generalization capability. Here, a physics-driven intelligent design (PDID) paradigm is proposed and demonstrates its application to design MDOF multiplexed metasurfaces. The PDID method integrates the physical prior knowledge into a deep neural network, thereby enhancing its physical interpretability and reducing its reliance on extensive databases. Compared to the traditional intelligent designs, this can reduce both design time and database size by two orders of magnitude. Through experimental validation of MDOF multiplexed metasurfaces, the versatility and computational efficiency of PDID are showed. This method not only presents a novel intelligent design tool but also exemplifies the integration of physical knowledge with machine learning to address the challenges. Its interdisciplinary insights offer significant potentials for innovative applications across the materials science, computational science, and information technology.}, archive = {J_ADVS}, author = {Jian Lin Su and Zi Xuan Cai and Yiqian Mao and Long Chen and Xin Yi Yu and Zhi Cai Yu and Qian Ma and Si Qi Huang and Jianan Zhang and Jian Wei You and Tie Jun Cui}, doi = {10.1002/advs.202503899}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503899}, shortjournal = {Adv. Sci.}, title = {Multi-dimensional multiplexed metasurface for multifunctional near-field modulation by physics-driven intelligent design}, volume = {12}, year = {2025}, }
• (2025). Composite mapping for peptide-based data storage with higher coding density and fewer synthesis cycles. ADVS, 12(27), 2503790. (www)

  @article{ , abstract = {Peptides are natural information-bearing mediums and are promising for high-density data storage. However, conventional mapping of one amino acid (AA) to one binary code has limited the improvement of coding density by increasing the total number of different AAs. Here, a novel composite mapping strategy is developed, where each position in the peptide sequence is a composite letter consisting of several different AAs, and thousands of composite letters are available for mapping, thus breaking the limit of conventional mapping. When 20 different AAs are used, the coding density of six-AAs composite mapping achieves 15 bits/letter, while conventional mapping only reaches 4 bits/AA. The whole process of encoding data into composite letter sequences, synthesizing composite letter sequences via solid-phase peptide synthesis, sequencing composite letter sequences by mass spectrometry, and decoding data from composite letter sequences is successfully demonstrated for the first time. Composite mapping also demonstrates several distinct advantages, including high coding density, few synthesis cycles, high reliability against errors, low probability of homopolymers, and good compatibility with other encoding algorithms. The developed composite mapping strategy provides a novel way for peptide-based data storage to increase the coding density and reduce the synthesis cycles, showing great potential for large-scale data storage.}, archive = {J_ADVS}, author = {Anxun Zhang and Longjie Wang and Xiaowei Zhai and Yao Xiao and Yanchan Wu and Yongxi Zhao and Kai Liu and Ji-Shen Zheng and Dong Chen}, doi = {10.1002/advs.202503790}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503790}, shortjournal = {Adv. Sci.}, title = {Composite mapping for peptide-based data storage with higher coding density and fewer synthesis cycles}, volume = {12}, year = {2025}, }
• (2025). Targeted penetrating motif engineering of BH3 mimetic: Harnessing non-canonical amino acids for coinhibition of MCL-1 and BCL-xL in acute myeloid leukemia. ADVS, 12(27), 2503682. (www)

  @article{ , abstract = {Acute Myeloid Leukemia (AML) remains a formidable clinical challenge, predominantly due to the emergence of resistance to existing therapeutic regimens, including BCL-2 inhibitors like Venetoclax. Here, a novel approach is introduced by engineering BH3 mimetics utilizing non-canonical amino acids (ncAAs) to achieve dual inhibition of MCL-1 and BCL-xL. Through site saturation mutagenesis scanning, the I58(Chg) mutation is identified, significantly enhancing binding affinity with IC 50 values of 2.77 n m for MCL-1 and 10.69 n m for BCL-xL, reflecting an increase of fourfold or more. The developed vMIP-II-TAT-I peptide, incorporating a CXCR4-targeted penetrating motif, demonstrated superior cellular uptake, with mean fluorescence intensity (MFI) 7.2-fold higher in CXCR4-positive AML cells and exhibited a high selectivity index (SI) for AML cells, with minimal impact on normal human hematopoietic stem cells (HSCs). When combined with Venetoclax, this peptide induced synergistic apoptosis, reducing tumor burden and prolonging survival in an AML mouse model, with median survival extended to 53 days from 37 days with Venetoclax alone. These findings reveal the therapeutic potential of dual inhibition in overcoming Venetoclax resistance and selectively targeting leukemic cells with reduced off-target effects, while laying the foundation for developing advanced BH3 mimetics with enhanced targeting, binding affinity, and efficacy for AML treatment.}, archive = {J_ADVS}, author = {Zhe Wang and Ruizhi Lai and Xinpei Wang and Xu Chen and Youjian Zhou and Shengbin Li and Xiaohui Qiu and Zekai Zeng and Jianye Yuan and Jinghuan Mao and Zhidong Chen and Junqing Wang}, doi = {10.1002/advs.202503682}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503682}, shortjournal = {Adv. Sci.}, title = {Targeted penetrating motif engineering of BH3 mimetic: Harnessing non-canonical amino acids for coinhibition of MCL-1 and BCL-xL in acute myeloid leukemia}, volume = {12}, year = {2025}, }
• (2025). Vertically aligned carbon nanotube mechano-electrochemical generator for ultralow-frequency ocean wave monitoring. ADVS, 12(27), 2503578. (www)

  @article{ , abstract = {Ultralow-frequency waves contain crucial information related to natural disasters; however, conventional technologies are limited in their ability to measure them accurately. To address this challenge, a novel vertically aligned CNT mechano-eletrochemical generator is proposed that generates electrical energy via fluctuation in the electrode-electrolyte interface. This generator utilizes ion movement based on electrochemical interactions, enabling it to generate electrical energy even in ultralow-frequency environments like ocean waves. In addition, the direct contact between the electrolyte and CNTs prevents signal degradation or distortion caused by packaging, allowing the precise detection of complex waveforms with overlapping frequencies. Given these characteristics, the generator exhibits broad applicability in complex environments, such as ocean monitoring. Furthermore, it demonstrates significant potential for future applications, such as self-powered oceanographic sensors and sustainable energy harvesting.}, archive = {J_ADVS}, author = {Hyeon Jun Sim and Dong Yeop Lee and Hocheol Gwac and Seungjin Lee and Joonhyeon Jeon and Seon Jeong Kim and Young-Kwan Kim and Chang-Seok Kim and Young-Jin Kim and Sooncheol Kwon and Changsoon Choi}, doi = {10.1002/advs.202503578}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503578}, shortjournal = {Adv. Sci.}, title = {Vertically aligned carbon nanotube mechano-electrochemical generator for ultralow-frequency ocean wave monitoring}, volume = {12}, year = {2025}, }
• (2025). Intraoperative fast adaptive focus tracking robotic OCT enables real-time tumor grading and large-area microvascular imaging in human spinal cord surgery. ADVS, 12(27), 2503566. (www)

  @article{ , abstract = {Current surgical procedures for spinal cord tumors lack in vivo high-resolution multifunctional imaging systems, hindering precise tumor resection. This study introduces the fast adaptive focus tracking robotic optical coherence tomography (FACT-ROCT) system, which provides real-time, artifact-free imaging during surgery, addressing motion artifacts and resolution degradation. Imaging occurs in 22 patients, including 13 with gliomas (WHO grade I-IV). This represents the first in situ OCT imaging of human spinal cord tumors, enabling the differentiation of tumor types in real-time. The standard deviation of the attenuation coefficient serves as a physical marker, achieving 90.2%  ±  2.7% accuracy in distinguishing high- from low-grade gliomas intraoperatively at a threshold of 0.75  ±  0.01 mm −1 . FACT-ROCT also enables microvascular imaging, covering areas of 70 mm × 13 mm × 10 mm within 2 min and revealing greater vascular tortuosity in higher-grade tumors. This extensive imaging capability provides critical information that guides surgical strategies, enhancing surgical outcomes. Overall, FACT-ROCT represents a significant advancement in intraoperative imaging, offering high-resolution, high-speed, and comprehensive insights into spinal cord tumor structure and vasculature.}, archive = {J_ADVS}, author = {Bin He and Yuzhe Ying and Yejiong Shi and Zhe Meng and Zichen Yin and Zhengyu Chen and Zhangwei Hu and Ruizhi Xue and Linkai Jing and Yang Lu and Zhenxing Sun and Weitao Man and Youtu Wu and Dan Lei and Ning Zhang and Guihuai Wang and Ping Xue}, doi = {10.1002/advs.202503566}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503566}, shortjournal = {Adv. Sci.}, title = {Intraoperative fast adaptive focus tracking robotic OCT enables real-time tumor grading and large-area microvascular imaging in human spinal cord surgery}, volume = {12}, year = {2025}, }
• (2025). Biomimetic microfluidic pumps for selective Oil–Water separation. ADVS, 12(27), 2503511. (www)

  @article{ , abstract = {Addressing the challenges posed by oil pollution from both domestic and industrial sources—which contributes to energy waste and environmental degradation—is critical. Here, a new, efficient, and sustainable oil/water separation system is presented using biomimetic spring microchannels created through precise projection micro-stereolithography-based 3D printing technique. This innovative system allows for the swift separation of mixed oil and water phases into distinct and pure streams, achieving a high separation flux of up to 292.5 L m −2 h −1 . The separation efficiency, consistently maintained over 99%, leverages the synergistic effects of surface wettability and molecular polarity to handle multiple oils with varying densities and surface tensions. Moreover, the biomimetic microchannels precise capturing of the oil/water interface and offer flexibility to initiate separation by prefilling the channels with either oil or water. Furthermore, these microchannels effectively prevent clogging, ensuring sustained performance. A significant enhancement is also demonstrated in separating crude oil from water by solar irradiation to reduce its viscosity, with a notable separation rate of 22.5 L m −2 h −1 for individual channels. The findings underscore the potential of 3D bionic functional spring microchannels for selectively separating a wide range of oil-water mixtures with exceptional efficiency.}, archive = {J_ADVS}, author = {Zhaolong Wang and Yinfeng Li and Mingzhu Xie and Ziheng Zhan and Wenhao Li and Qihui Xie and Yong Shuai and Zhichao Dong and Zuankai Wang}, doi = {10.1002/advs.202503511}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503511}, shortjournal = {Adv. Sci.}, title = {Biomimetic microfluidic pumps for selective Oil–Water separation}, volume = {12}, year = {2025}, }
• (2025). Bioinspired liquid-free ion-conductive elastomers with ultrahigh mechanical strength and excellent ionic conductivity for multifunctional flexible sensing applications. ADVS, 12(27), 2503510. (www)

  @article{ , abstract = {Liquid-free ion-conductive elastomers with excellent mechanical and electrical conductivity are widely used in flexible sensors, wearable devices, soft touch screens, and supercapacitors. However, the inherent contradiction between mechanical and electrical properties often limits the development of liquid-free ion-conductive elastomers. Therefore, the preparation of liquid-free ion-conductive elastomers with both high mechanical properties and high ionic conductivity remains a major challenge. In this study, a polyurethane elastomer with multiple crosslinking and a microphase-separated structures were designed, inspired by the “brick wall” structure of the pearl layer. A polyurethane-based liquid-free ion-conductive elastomer with excellent mechanical strength and outstanding ion-conducting properties was prepared by introducing lithium bis(trifluoromethane)sulfoximide (LiTFSI) into the polyurethane elastomer. FLICE-110% liquid-free ion-conductive elastomer had excellent mechanical strength (5.46 MPa), exceptional elongation at break (1213%), excellent ionic conductivity (3.29 × 10 −4 S cm −1 ), and excellent fracture energy (6.25 kJ m −2 ). Flexible sensors prepared based on FLICE-110% liquid-free ion-conductive elastomer have realized applications in wearable devices, multi-channel strain sensors, and remote-controlled robots. In addition, we successfully recovered LiTFSI from FLICE-110% liquid-free ion-conductive elastomer. The development of these liquid-free ion-conductive elastomers will be expected to show a wide range of applications in flexible sensors, ionic skin, soft robotics, and human-machine interactions.}, archive = {J_ADVS}, author = {Zequan Li and Jingjing Tang and Xuwei Wang and Fuqi Wang and Fangyan Ou and Wenyu Pan and Changsheng Wang and Ting Xie and Chuang Ning and Xiwei Xu and Jiamin Liu and Qihua Liang and Wei Gao and Shuangliang Zhao}, doi = {10.1002/advs.202503510}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503510}, shortjournal = {Adv. Sci.}, title = {Bioinspired liquid-free ion-conductive elastomers with ultrahigh mechanical strength and excellent ionic conductivity for multifunctional flexible sensing applications}, volume = {12}, year = {2025}, }
• (2025). In situ construction of multi-functional polymer network toward durable perovskite solar cells. ADVS, 12(27), 2503417. (www)

  @article{ , abstract = {Enhancing the crystalline quality of perovskite thin films and stabilizing their internal grain boundaries are essential in guaranteeing the extended longevity of perovskite solar cells. Herein, an in situ polymerization strategy is presented to produce weak chemical bond networks in perovskite films. The introduction of acrylamide monomer into the perovskite precursor solution facilitates the rearrangement of [PbI 6 ] 4− octahedra, resulting in a significant enhancement of the crystal quality of the perovskite films. With the presence of C═C bonds, the in situ polymerization of acrylamide at grain boundaries can form polymer networks, which can efficiently passivate the detrimental defects associated with grain boundaries. The perovskite solar cells with an impressive power conversion efficiency (PCE) of 26.05% (certified at 25.06%) are achieved, combined with highly improved operational stability with T 98 = 2034 h. As expected, large-area module based on this strategy achieved an impressive PCE of 23.02% with an active area of 14 cm 2 .}, archive = {J_ADVS}, author = {Bingqian Zhang and Qiangqiang Zhao and Kun Gao and Xiaoxu Zhang and Caiyun Gao and Xiuhong Sun and Hongpei Ji and Xiaopeng Feng and Yaliang Han and Xiaofei Yan and Xiao Wang and Zhipeng Shao and Shuping Pang and Kezheng Chen and Guanglei Cui}, doi = {10.1002/advs.202503417}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503417}, shortjournal = {Adv. Sci.}, title = {In situ construction of multi-functional polymer network toward durable perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Electrochemical-genetic programming of protein-based magnetic soft robots for active drug delivery. ADVS, 12(27), 2503404. (www)

  @article{ , abstract = {Magnetic soft robots have the potential to revolutionize the field of drug delivery owing to their capability to execute tasks in hard-to-reach regions of living organisms. Advancing their functionality to perform active drug delivery and related tasks necessitates the innovation of smart substrate materials that satisfy both mechanical and biocompatibility requirements while offering stimuli-responsive properties. Optimization of the interaction between the substrate and magnetic components is also critical as it ensures robust actuation of the robot in complex physiological environments. To address these issues, a facile strategy is presented that synergistically combines genetic programming and electrochemical engineering to achieve on-demand drug release with protein-magnetite soft robots. As the substrate of the robot, genetically engineered silk-elastin-like protein (SELP) is encoded with thermo-responsive motifs, serving as the dynamic unit to respond to temperature changes. Ultrafine magnetite (Fe 3 O 4 ) nanocrystals are electrochemically nucleated in situ and grown on Fe-protein coordination sites within the SELP hydrogel network, endowing reinforced mechanical strength, superparamagnetic property, and photothermal conversion capability. These soft robots can navigate confined spaces, target specific sites, and release drug payloads ex vivo in an intestinal model. Taken together, the proposed strategy offers an innovative approach to tailoring protein-based soft robots toward precision drug delivery systems.}, archive = {J_ADVS}, author = {Hang Zhao and Bo Yu and Dingyi Yu and Ting Ji and Kexin Nie and Jingyi Tian and Xinchen Shen and Kaiyue Zhang and Junhan Ou and Xinyi Yang and Dongfang Xiao and Qi Zhou and Wenwen Huang}, doi = {10.1002/advs.202503404}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503404}, shortjournal = {Adv. Sci.}, title = {Electrochemical-genetic programming of protein-based magnetic soft robots for active drug delivery}, volume = {12}, year = {2025}, }
• (2025). An atypical heterojunction in favor of conversion of CO2 and sunlight into C2H4. ADVS, 12(27), 2503336. (www)

  @article{ , abstract = {Current heterojunction semiconduction assemblies, including type I, II, Z-Scheme, and S-Scheme constructures, enable the utilization of longer-wavelength sunlight for photocatalytic conversions. However, such benefits are often achieved at the expense of either the redox potentials of the conduction and valence bands or the quantum yield due to additional electron–hole recombination across the heterojunction interface. Herein, an atypical type II heterojunction constituted of Au/TiO 2 /MFU-4l is reported that demonstrates outstanding catalytic performance in photocatalytic reduction of carbon dioxide (CO 2 ) to ethylene (C 2 H 4 ) through tuning up-converting of holes in MFU-4l component raised from full-spectrum solar irradiation. Anchored to the edge of cube MFU-4l with a TiO 2 cover layer, aurum ions (Au + )supported by aurum (Au) nanoparticles enables such a reverse hole-transfer event through leveraging the Ti-O −• -Au +/0 - •− O-Zn potential, which significantly accelerates the hole-dominated oxidative desaturation of C-C intermediates from CO 2 reduction into C═C bond products. The catalyst efficiently converts CO 2 to C 2 H 4 with more than 90% selectivity and a yield of 107.0 µmol g −1 h −1 under simulated sunlight. Electron paramagnetic resonance (EPR) experiments directly observe the holes formed in visible-light excited MFU-4l moiety of Au/TiO 2 /MFU-4l that are fused into TiO 2 component's holes, thereby generating more hydroxyl radicals (•OH) than that TiO 2 is excited alone under ultraviolet (UV) carbon dioxide (CO 2 ) light of the same intensity.}, archive = {J_ADVS}, author = {Qin He and Dongge Ma and Yangyang Du and Qiang Huang and Jianfei Ji and Xu Wang and Hongwei Ji and Wanhong Ma and Jincai Zhao}, doi = {10.1002/advs.202503336}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503336}, shortjournal = {Adv. Sci.}, title = {An atypical heterojunction in favor of conversion of CO2 and sunlight into C2H4}, volume = {12}, year = {2025}, }
• (2025). Precision nanoconfined self-assembly of ACQ carbon dots for enhanced solid-state fluorescence. ADVS, 12(27), 2503317. (www)

  @article{ , abstract = {Carbon dots (CDs) are promising fluorescent nanomaterials, however, they are often hindered by aggregation caused quenching (ACQ) in solid-state application because of close π–π stacking interactions. Furthermore, the challenges still exist in the development of CDs-based solid-state fluorescent materials with stable structure and high fluorescence intensity. To address this challenge, a general and robust polymer directed nanoconfined self-assembly strategy is developed, enabling the fabrication of regular morphology, structurally ultra-stable and solid-state fluorescent CDs assemblies using hydrophilic star-liked di-block copolymer unimolecular micelles as templates. The absolute photoluminescence quantum yield (PLQY) of these fluorescent solid-state CD assemblies reaches 21.46%, significantly higher than 0.12% observed in traditional ACQ solid-state CDs. The enhanced solid-state fluorescent property is attributed to the prevention of the π–π stacking of CDs, the restricted movement of surface groups and the suppression of non-radiative transition processes via the polymer directed nanoconfined self-assembly of CDs. The fluorescence intensity of CDs assemblies can also be precisely tuned by adjusting the polymerization time of polymer template. Based on these advantages, the CDs assemblies are employed as luminescent materials in the identification of latent fingerprints (LFP), flexible films and 3D printing functional hydrogels.}, archive = {J_ADVS}, author = {Jingyi Hao and Wenjie Zhang and Yuying Li and Wenjun Ma and Yueying Zhu and Junle Zhang and Ge Shi and Xiaoguang Qiao and Yanjie He and Zheng Zhao and Xinchang Pang and Ben Zhong Tang}, doi = {10.1002/advs.202503317}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503317}, shortjournal = {Adv. Sci.}, title = {Precision nanoconfined self-assembly of ACQ carbon dots for enhanced solid-state fluorescence}, volume = {12}, year = {2025}, }
• (2025). Linear polymer cathode materials for highly efficient aqueous zinc-ion batteries: Is the high active sites density necessary?. ADVS, 12(27), 2503156. (www)

  @article{ , abstract = {Recently, research on aqueous zinc-ion batteries (AZIBs) has always focused on improving the energy storage performance by increasing the number of active sites, particularly in designing organic/polymer materials with a high density of active sites. However, does a higher density of active sites necessarily induce enhanced energy storage performance? To verify this issue, we have designed two linear polymers, where TAPT-DHBQ contains an additional pair of active sites (carbonyl groups) compared to TABQ-DHBQ, with theoretical specific capacities of 545.26 and 379.14 mAh g −1 , respectively. Interestingly, the experimental results have deviated with the specific capacities of these polymers being comparable, measuring to be 325 mAh g −1 (TABQ-DHBQ) and 280 mAh g −1 (TAPT-DHBQ). This is attributed to the competition effect between neighboring active sites, which leads to decreased utilization of active sites. As a result, the Zn//TABQ-DHBQ batteries with ZnI 2 electrolyte additive have exhibited high specific capacities of 618 and 360 mAh g −1 at the current densities of 1 and 10 A g −1 , along with a high energy density of 678.6 Wh kg −1 (1 A g −1 ). The finding underscores the importance of uniform electron cloud distribution in cathode materials for achieving efficient AZIBs.}, archive = {J_ADVS}, author = {Yiyang Dai and Yao Yao and Liang Feng and Zhenglong Qiu and Min Deng and Qiang Peng}, doi = {10.1002/advs.202503156}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503156}, shortjournal = {Adv. Sci.}, title = {Linear polymer cathode materials for highly efficient aqueous zinc-ion batteries: Is the high active sites density necessary?}, volume = {12}, year = {2025}, }
• (2025). Ecofriendly sunlight-mediated nontoxic bimetallic nanoparticles: Synthesis, reusable catalytic membrane, and biosensor applications. ADVS, 12(27), 2503120. (www)

  @article{ , abstract = {Bimetallic nanoparticles (BMNPs) combine the desirable properties of two distinct metals that outperform conventional monometallic nanoparticles (NPs). This work presents a novel ecofriendly silver-copper (Ag–Cu) BMNPs synthesis using sunlight as a green reducing agent, enableing rapid Ag–Cu BMNPs formation at room temperature within 10 min. This method exploiting the facile reduction of Ag⁺ to Ag⁰, which subsequently mediates the reduction of Cu 2 ⁺ to Cu⁰ via water radiolysis-generated species. The Ag–Cu BMNPs were integrated into two reusable catalytic membranes: PTFE@Ag–Cu, formed by immobilizing Ag–Cu BMNPs onto a polytetrafluoroethylene (PTFE) syringe filter, and ACF@Ag–Cu, synthesized via in-situ growth of Ag–Cu BMNPs on activated carbon fiber (ACF) cloth. PTFE@Ag–Cu displays exceptional performance and reusability, converting 2100 mL of 0.15 mM p -nitrophenol to p -aminophenol over 105 cycles at a flow rate of 20 mL min −1 . The Ag–Cu BMNPs also exhibit peroxidase-mimic activity, enabling colorimetric H 2 O 2 detection with a range of 0–200 mM and a limit of detection (LOD) of 13.3 µM in solution. Further, the Ag–Cu nanoenzyme demonstrates strong potential for electrochemical glucose detection, achieving an LOD of 0.1 µM and sensitivity of 5221 µA × 10 −6 m ⁻ 1 cm⁻ 2 .}, archive = {J_ADVS}, author = {Samy M. Shaban and Sihyeok Kim and N. M. El Basiony and Jincymol Kappen and Mohamed H. Mostafa and Ahmed Y. Elbalaawy and Mohamed R. Elmasry and Jihoon Shin and Il Jeon and Dong-Hwan Kim}, doi = {10.1002/advs.202503120}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503120}, shortjournal = {Adv. Sci.}, title = {Ecofriendly sunlight-mediated nontoxic bimetallic nanoparticles: Synthesis, reusable catalytic membrane, and biosensor applications}, volume = {12}, year = {2025}, }
• (2025). Unveiling the excited-state dynamics and interfacial interactions in dye-sensitized NaNdF4 nanoparticles for efficient photothermal effect. ADVS, 12(27), 2503110. (www)

  @article{ , abstract = {Near-infrared (NIR) dyes can overcome the weak absorption of lanthanide nanoparticles (NPs) by antenna sensitization, offering new avenues to develop efficient and versatile lanthanide nanomaterials. However, current research on dye-sensitized lanthanide NPs for photothermal conversion is still preliminary, and the involved excited-state dynamics and interfacial interactions remain elusive. Herein, steady-state/transient absorption spectroscopy and theoretical calculation are used to investigate the coordination and aggregation states of cypate dyes on NaNdF 4 NPs, revealing the influence of interfacial interactions on resonant energy transfer. Synergetic heat-generation mechanism of lanthanide cross-relaxation and dye intermolecular collisions is further proposed. The photothermal conversion efficiency of cypate-NaNdF 4 nanocomposites reaches 50.4%, outperforming those of typical photothermal materials with high NIR absorption. Moreover, the intersystem crossing of cypate can be inhibited due to the depopulation of the S 1 exciton via ET, thereby improving anti-photobleaching ability. These dye-sensitized NaNdF 4 nanocomposites exhibit superior photothermal effect, stability and NIR-II luminescence, showing great potential in theranostic applications.}, archive = {J_ADVS}, author = {Jiacheng Gong and Wusen Zhou and Zhuo Li and Xingjun Li and Wen Yuan and Xiaobo Gu and Qianqian Niu and Yan Liu and Jin Xu and Renfu Li and Datao Tu and Shan Lu and Xueyuan Chen}, doi = {10.1002/advs.202503110}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503110}, shortjournal = {Adv. Sci.}, title = {Unveiling the excited-state dynamics and interfacial interactions in dye-sensitized NaNdF4 nanoparticles for efficient photothermal effect}, volume = {12}, year = {2025}, }
• (2025). Blockchain-empowered H-CPS architecture for smart agriculture. ADVS, 12(27), 2503102. (www)

  @article{ , abstract = {This study integrates blockchain technology into smart agriculture to enhance its productivity and sustainability. By combining blockchain with remote sensing, artificial intelligence (AI), and the Internet of Things (IoT), a Human-Cyber-Physical System (H-CPS) architecture tailored for agricultural applications is proposed. It supports real-time crop management, data-driven decision-making, and transparent trading of agricultural products. A semantic-based blockchain framework is introduced to address challenges in data management and AI model integration, optimizing production, improving traceability, reducing costs, and enhancing financial security. This framework directly addresses real-world agricultural challenges, such as optimized irrigation, improved crop breeding efficiency, and enhanced supply chain transparency. These innovations provide practical solutions for modern agriculture, contributing to sustainable development and global food security. Further research and collaboration are encouraged to unlock its full potential in transforming agricultural practices.}, archive = {J_ADVS}, author = {Xiaoding Wang and Qibin Wu and Haitao Zeng and Xu Yang and Hui Cui and Xun Yi and Md. Jalil Piran and Ming Luo and Youxiong Que}, doi = {10.1002/advs.202503102}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503102}, shortjournal = {Adv. Sci.}, title = {Blockchain-empowered H-CPS architecture for smart agriculture}, volume = {12}, year = {2025}, }
• (2025). Development and breeding of herbicide-resistant sorghum for effective cereal-legume intercropping. ADVS, 12(27), 2503083. (www)

  @article{ , abstract = {Weeds bring a serious challenge to crop production, and herbicides is the most effective and economic way to manage it in field. Sorghum is a critical crop for staple food, fodder, and biofuel. However, the lack of herbicide-resistant sorghum germplasm severely impedes its production. Here, we conducted a large-scale screening and identified 13 sorghum mutant lines resistant to imidazolinone (IMI) herbicides. Two unique mutation sites in SbALS ( acetolactate synthase ), thus namely Sbals-1 (A93T) and Sbals-2 (S624N) are discovered, both enhance sorghum tolerance to imazamox. Notably, under high concentrations of imazamox, sbals-1 presented a superior growth phenotype and elevated Sb ALS activity than sbals-2 , a difference that can be attributed to the predicted protein structures. Breeding with Sbals , both grain- and grass-type sorghum, shows great weed control and field performance. The herbicide imazamox resistance is further evaluated in a soybean population for sorghum-soybean strip intercropping, identifying 123 highly resistant soybean varieties. Field intercropping tests indicated health growth of both soybean and sorghum lines post-imazamox treatment, which enhance field clearance of weed. This study, therefore, provides valuable insights not only for herbicide-resistant sorghum breeding but also for the successful implementation of efficient and sustainable cereal-legume intercropping systems.}, archive = {J_ADVS}, author = {Sanyuan Tang and Jiayang Shi and Xuefeng Li and Mingliang Yang and Chao Li and Dan Zhang and Sen Yang and Cuo Mei and Zuyong Luo and Li Zhang and Wanke Zhang and Chunrui Zhang and Chenbo Zhu and Xiaowei Ma and Ran Xia and Yuhang Chen and Jinsong Zhang and Qingshan Chen and Shouyi Chen and Qi Xie and Feifei Yu}, doi = {10.1002/advs.202503083}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503083}, shortjournal = {Adv. Sci.}, title = {Development and breeding of herbicide-resistant sorghum for effective cereal-legume intercropping}, volume = {12}, year = {2025}, }
• (2025). Real-time self-optimization of quantum dot laser emissions during machine learning-assisted epitaxy. ADVS, 12(27), 2503059. (www)

  @article{ , abstract = {Traditional methods for optimizing light source emissions rely on a time-consuming trial-and-error approach. While in situ optimization of light source gain media emission during growth is ideal, it has yet to be realized. In this work, in situ reflection high-energy electron diffraction (RHEED) is integrated with machine learning (ML) to correlate the surface reconstruction with the photoluminescence (PL) of InAs/GaAs quantum dots (QDs), which serve as the active region of lasers. A lightweight ResNet-GLAM model is employed for the real-time processing of RHEED data as input, enabling effective identification of optical performance. This approach guides the dynamic optimization of growth parameters, allowing real-time feedback control to adjust the QDs emission for lasers. InAs QDs on GaAs substrates are successfully optimized, with a 3.2-fold increase in PL intensity and a reduction in full width at half maximum (FWHM) from 36.69 to 28.17 meV. Automated, in situ self-optimized lasers with 5-layer InAs QDs achieved electrically pumped continuous-wave operation at 1240 nm with a low threshold current of 150 A cm − 2 at room temperature, an excellent performance comparable to samples grown through traditional manual multi-parameter optimization methods. These results mark a significant step toward intelligent, low-cost, and reproductive light emitters production.}, archive = {J_ADVS}, author = {Chao Shen and Wenkang Zhan and Shujie Pan and Hongyue Hao and Ning Zhuo and Kaiyao Xin and Hui Cong and Chi Xu and Bo Xu and Tien Khee Ng and Siming Chen and Chunlai Xue and Zhanguo Wang and Chao Zhao}, doi = {10.1002/advs.202503059}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503059}, shortjournal = {Adv. Sci.}, title = {Real-time self-optimization of quantum dot laser emissions during machine learning-assisted epitaxy}, volume = {12}, year = {2025}, }
• (2025). CXCL6 reshapes lipid metabolism and induces neutrophil extracellular trap formation in cholangiocarcinoma progression and immunotherapy resistance. ADVS, 12(27), 2503009. (www)

  @article{ , abstract = {The chemokine CXCL6 is identified as a pivotal regulator of biological processes across multiple malignancies. However, its function in cholangiocarcinoma (CCA) is underexplored. Tumor profiling for CXCL6 is performed using a public database. Both in vitro and in vivo experiments are utilized to evaluate the oncogenic effects of CXCL6 on CCA. Additionally, RNA-Seq is employed to detect transcriptomic changes related to CXCL6 expression in CCA cells and neutrophils. Molecular docking, fluorescence colocalization, and Co-IP are used to elucidate a direct interaction between JAKs and CXCR1/2. Additionally, LC-MS lipidomics and explored the impact of CXCL6 on immunotherapy in vivo. CXCL6 is upregulated in CCA tissues and promoted the proliferation and metastasis of CCA. Mechanistically, CXCL6 regulated the CXCR1/2-JAK-STAT/PI3K axis in CCA via autocrine signaling, leading to lipid metabolic reprogramming, and promoted neutrophil extracellular traps (NETs) formation by activating the RAS/MAPK pathway in neutrophils. Eventually, NETs formation induced immunotherapy resistance in CCA by blocking CD8 + T cell infiltration. CXCL6 modulates CCA progression through the CXCR1/2-JAK-STAT/PI3K axis and reshaping its lipid metabolism. CXCL6 also mediates immunotherapy resistance through NETs, which may be a potential therapeutic target and biomarker for CCA.}, archive = {J_ADVS}, author = {Tian He and Zi-Yi Wang and Bin Xu and Cheng-Jie Zhong and Lu-Na Wang and Huan-Chen Shi and Zi-Yue Yang and Shi-Qi Zhou and Hui Li and Bo Hu and Xiao-Dong Zhu and Ying-Hao Shen and Jian Zhou and Jia Fan and Hui-Chuan Sun and Cheng Huang}, doi = {10.1002/advs.202503009}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2503009}, shortjournal = {Adv. Sci.}, title = {CXCL6 reshapes lipid metabolism and induces neutrophil extracellular trap formation in cholangiocarcinoma progression and immunotherapy resistance}, volume = {12}, year = {2025}, }
• (2025). A soft-soft contact triboelectric nanogenerator with a ternary four-phase structure for self-powered high-efficiency dust removal on mars. ADVS, 12(27), 2502956. (www)

  @article{ , abstract = {Dust removal is essential for sustaining energy supplies in Mars exploration missions and base facilities. Existing devices typically depend on external power supplies, which may be inadequate in the harsh Martian environment. This paper proposes a novel wind-driven ternary four-phase soft-soft contact triboelectric nanogenerator (FPS-TENG) for dust removal. The device's double-stacked soft-soft contact structure outputs high-voltage electricity in four phases, generating a traveling wave electric field on the electrode surface. This field prompts dust particles to align with the wave's direction, enabling automatic dust removal without an external power supply. The FPS-TENG, as a ternary stacked soft-soft contact TENG, achieves output voltages that are 354% and 185% higher than those of conventional binary and ternary TENGs, respectively. Compared with existing dust removal devices, this device can achieve a dust removal efficiency of up to 91.8% for simulated Martian dust, even at lower voltages, without requiring the repositioning of solar panels during the cleaning process. Experimental results validate the system's operation in the Martian environment. This work provides a self-powered, high-efficiency method for dust removal that holds significant promise for promoting wider space exploration and supporting potential future Martian settlements.}, archive = {J_ADVS}, author = {Fei Yang and Zheping Wang and Boyi Xu and Yifan Lu and Xuyan Hou and Jinsui Xu and Zhijie Xie}, doi = {10.1002/advs.202502956}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502956}, shortjournal = {Adv. Sci.}, title = {A soft-soft contact triboelectric nanogenerator with a ternary four-phase structure for self-powered high-efficiency dust removal on mars}, volume = {12}, year = {2025}, }
• (2025). Hierarchical icephobic surfaces with enhanced photothermal performance for sustainable anti-icing. ADVS, 12(27), 2502945. (www)

  @article{ , abstract = {Icing remains a major challenge in industrial and environmental applications, leading to efficiency losses, safety hazards, and substantial economic impacts. Conventional deicing methods are energy-intensive and environmentally unsustainable, often requiring high energy inputs, extensive operational maintenance, or the use of harmful chemicals. These drawbacks underscore the need for advanced, scalable solutions that are both efficient and environmentally responsible. Here, the armored photothermal icephobic structured surface (APISS) is presented that combines superhydrophobicity and photothermal effects to deliver superior anti-icing performance. The APISS consists hierarchical micro-nanostructures with titanium nitride (TiN) nanoparticles encapsulated in a silica shell, ensuring exceptional durability and efficient solar energy conversion. Under 1 sun illumination, APISS achieves a temperature increase of 35 °C, effectively melting ice within 179 s and preventing refreezing. Its superhydrophobic properties facilitate the removal of melted water, maintaining a clean and dry surface. Comprehensive testing reveals that APISS significantly outperforms existing anti-icing materials in scalability, durability, and sustainability, making it highly suitable for renewable energy, aviation, and infrastructure maintenance. The work highlights APISS as an advanced approach to anti-icing technology, addressing critical challenges with a scalable and environmentally friendly solution.}, archive = {J_ADVS}, author = {Lei Zhang and Yongle Feng and Xixin Cao and Yue Dong and Weihong Liu and Bing Li and Jing Li and Chonglei Hao}, doi = {10.1002/advs.202502945}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502945}, shortjournal = {Adv. Sci.}, title = {Hierarchical icephobic surfaces with enhanced photothermal performance for sustainable anti-icing}, volume = {12}, year = {2025}, }
• (2025). Superior capacitive energy storage of BaTiO3-based polymorphic relaxor ferroelectrics engineered by mesoscopically chemical homogeneity. ADVS, 12(27), 2502916. (www)

  @article{ , abstract = {Relaxor ferroelectrics exhibit giant potentials in capacitive energy storage, however, the scales of polar nanoregions determine the critical field values where the polarization saturation occurs. In this work, a mesoscopic structure engineered ergodic relaxor state is realized by adjusting submicron-grain scaled chemical homogenity, exhibiting polymorphic polar nanoregions of various scales in different grains. This produces a relatively continuous polarization switching with increasing the applied electric field from diverse grains, thus resulting in a linear-like polarization response feature. As a result, both a giant energy density ( W rec ) ≈15.4 J cm −3 and a field-insensitive ultrahigh efficiency ( η ) ≈93.2% are simultaneously achieved at 78 kV mm −1 in (Ba, Ca)(Ti, Zr)O 3 -(Bi 0.5 Na 0.5 )SnO 3 lead-free ceramics. Moreover, both the mesoscopic structure heterogeneity and complex high internal stresses in ultrafine grains decrease the temperature sensitivity of the nanodomain structural features. Together with the suppressed high-temperature defect motion from high ceramic density and submicron grain size, a record-high temperature stability with W rec = 10.4±5% J cm −3 and η = 96±3% is obtained at 65 kV mm −1 and 0–250 °C, demonstrating great application potential of the studied ceramic in high-temperature energy storage capacitors. The proposed strategy in this work greatly expands the design mentality for next-generation high-performance energy-storage dielectrics.}, archive = {J_ADVS}, author = {Aiwen Xie and Ziyi Yu and Junwei Lei and Yi Zhang and Ao Tian and Xuewen Jiang and Xinchun Xie and Yuewei Yin and Zhenqian Fu and Xiaoguang Li and Ruzhong Zuo}, doi = {10.1002/advs.202502916}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502916}, shortjournal = {Adv. Sci.}, title = {Superior capacitive energy storage of BaTiO3-based polymorphic relaxor ferroelectrics engineered by mesoscopically chemical homogeneity}, volume = {12}, year = {2025}, }
• (2025). Oxygen vacancy defect engineering for transverse thermoelectric enhancement: A novel extrinsic pathway beyond intrinsic approaches. ADVS, 12(27), 2502892. (www)

  @article{ , abstract = {For efficient transverse thermoelectric (TE) generation, research has primarily focused on achieving high transverse TE conductivity by utilizing intrinsic material properties. While this approach remains fundamental, exploring extrinsic strategies, such as defect engineering, offers new opportunities to further enhance performance and expand the range of applicable materials. This study investigates the impact of oxygen vacancies—an extrinsic factor—on the anomalous Nernst effect, a key transverse TE mechanism, using disordered semiconducting Sr 3 YCo 4 O 11- δ ( δ = 0.02, 0.08 and 0.14) as a model system. The highest anomalous Nernst thermopower ( S ANE ) occurs at δ = 0.14, showing a 44% increase compared to δ = 0.02. This enhancement arises from two synergistic effects: i) increased Co 3+ /Co 4+ mixed valency, boosting entropy-driven charge transport and Seebeck thermopower, and ii) distortions in the Co-O-Co bond angle, elevating the local density of states and the anomalous Nernst angle. These findings establish oxygen vacancy defect engineering as a potent strategy for enhancing transverse TE performance, broadening the spectrum of viable TE materials for diverse engineering applications.}, archive = {J_ADVS}, author = {Min Young Kim and Dongkyu Lee and June Ho Lee and Donghwa Lee and Gi-Yeop Kim and Si-Young Choi and Joseph P. Heremans and Hyungyu Jin}, doi = {10.1002/advs.202502892}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502892}, shortjournal = {Adv. Sci.}, title = {Oxygen vacancy defect engineering for transverse thermoelectric enhancement: A novel extrinsic pathway beyond intrinsic approaches}, volume = {12}, year = {2025}, }
• (2025). A sub-diffraction-limit dimension all-plasmonic optical memory using non-linear photochromism. ADVS, 12(27), 2502890. (www)

  @article{ , abstract = {The development of compact, high-speed, and energy-efficient optical memories remains a significant challenge in photonic and plasmonic technologies. Conventional optical memories are inherently limited by light diffraction, restricting miniaturization and causing inefficient energy transfer. A promising strategy to overcome these limitations is using propagating surface plasmon polaritons (SPPs), enabling the confinement and propagation of optical fields along metal interfaces, and allowing photonic devices to scale down to sub-diffraction-limit dimensions. This work presents an all-plasmonic optical memory system based on silver nanowires (AgNWs) coated with photochromic diarylethene (DAE). By utilizing SPPs, reversible Write/Erase functions are achieved through multiphoton excitation, modulating the photostationary state of DAE. The refractive index changes regulate SPP propagation efficiency along the AgNW, with the memory state being read via plasmonic second-harmonic generation. The synergy between nonlinear plasmonics in AgNWs and the photochromic properties of DAE enables complete memory operations, including writing, erasing, and reading ON/OFF states. This sub-diffraction-limit system paves the way for ultra-compact, molecular-scale optical memory devices.}, archive = {J_ADVS}, author = {Shuichi Toyouchi and Mathias Wolf and Kenji Hirai and Yasuhiko Fujita and Tomoko Inose and Beatrice Fortuni and Eduard Fron and Johan Hofkens and Steven De Feyter and James Hutchison and Tsuyoshi Fukaminato and Hiroshi Uji-i}, doi = {10.1002/advs.202502890}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502890}, shortjournal = {Adv. Sci.}, title = {A sub-diffraction-limit dimension all-plasmonic optical memory using non-linear photochromism}, volume = {12}, year = {2025}, }
• (2025). Photocatalytic bilateral disulfuration of thioethers toward α-sulfide disulfides with antibacterial activity. ADVS, 12(27), 2502862. (www)

  @article{ , abstract = {α −Sulfide disulfides represent valuable motifs in organic and pharmaceutical chemistry. However, the limited availability of synthetic approaches for α −sulfide disulfides has impeded progress in this field. In this study, a photocatalytic approach to synthesizing modifiable α −sulfide disulfides is presented using accessible sulfides and a bilateral disulfurating reagent. The reaction proceeds under mild conditions and demonstrates broad substrate compatibility, accommodating both aromatic and aliphatic sulfides. Moreover, the synthesized α −sulfide disulfides display robust reactivity in subsequent transformations with different electrophiles. Notably, this protocol can also be applied to the modification of polymer matrices. Bioassays further reveal that certain target compounds exhibit significant antibacterial activity against plant pathogens, such as Xanthomonas oryzae pv. oryzae ( Xoo ), Xanthomonas oryzae pathovar oryzicola ( Xoc ), and Dickeya zeae ( D. zeae ).}, archive = {J_ADVS}, author = {Qingqiang Tian and Chuxia Wang and Bingrui Liu and Xiangwei Wu and Yahui Li}, doi = {10.1002/advs.202502862}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502862}, shortjournal = {Adv. Sci.}, title = {Photocatalytic bilateral disulfuration of thioethers toward α-sulfide disulfides with antibacterial activity}, volume = {12}, year = {2025}, }
• (2025). Constructing Dissolution–Resistant interphases for long-life sodium-ion batteries at elevated temperatures. ADVS, 12(27), 2502860. (www)

  @article{ , abstract = {Rechargeable sodium-ion batteries (SIBs) utilizing NaPF 6 -carbonate electrolytes consistently exhibit unsatisfactory cycle life at elevated temperatures, posing a significant challenge for their large-scale commercialization. This is mainly caused by the instability of interphase layers at elevated temperatures, especially the high solubility of interphase components (especially NaF) in carbonate solvents. In this study, a novel additive of sodium difluorobis(oxalato) phosphate (NaDFBOP) is synthesized and introduced into NaPF 6 -carbonate electrolytes to enhance the cycle life of commercial SIBs composed of NaNi 1/3 Fe 1/3 Mn 1/3 O 2 (NFM) cathode and hard carbon (HC) anode, particularly at 50 °C. Specifically, the NaDFBOP enables NFM/HC SIBs to retain 85.45% of initial capacity after 1000 cycles at 30 °C and 90.76% after 500 cycles at 50 °C. Theoretical calculations reveal that DFBOP⁻ anions enter the first solvation shell of Na + , and NaDFBOP exhibits a strong propensity for decomposition. Characterizations suggest that NaDFBOP favors the formation of dissolution–resistant robust interphase layers enriched of dissolution-resistant oxalate-containing species and inorganic NaF, which have strong mutual binding energy. This work underscores the critical importance of designing functional additives and constructing dissolution-resistant robust interphases to enhance the elevated temperature cycle life of SIBs.}, archive = {J_ADVS}, author = {Wenting Deng and Xiaofan Du and Gaojie Xu and Shitao Wang and Li Du and Tiantian Dong and Rongxian Wu and Chuanchuan Li and Zhaolin Lv and Jiangwei Ju and Xinhong Zhou and Guanglei Cui}, doi = {10.1002/advs.202502860}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502860}, shortjournal = {Adv. Sci.}, title = {Constructing Dissolution–Resistant interphases for long-life sodium-ion batteries at elevated temperatures}, volume = {12}, year = {2025}, }
• (2025). Enhanced electrical performance and stretchability by plasticizer-facilitated PEDOT:PSS self-alignment. ADVS, 12(27), 2502853. (www)

  @article{ , abstract = {Stretchable, soft electronics have high potential for wearable healthcare applications and biointerfacing. One approach to render inherently brittle conductive polymers such as poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) stretchable are organic plasticizers. However, little is known on how they affect the morphology and in result the electrical properties of conductive thin-films. This study fundamentally explores this relationship using a bilayer model of transfer-printed PEDOT:PSS on stretchable, biocompatible poly(vinyl alcohol) substrates infused with glycerol (15–55 wt.%). The diffusion of the plasticizer leads to a reorganization of PEDOT and PSS, which is investigated using a multicomponent diffusion model. This approach correctly predicts the (plasticizer-dependent) increase in conductivity that followed plasticizer diffusion and is attributed to the reorganization toward more interconnected PEDOT domains. In result, the system shows an improved electrical response to strain as well as crack-free elongation. Simultaneously, the electrical resistance decreases to one-fifth of its initial value, which is attributed to chain-alignment upon strain.}, archive = {J_ADVS}, author = {Carla Volkert and Mateusz Brzezinski and Pablo Gomez Argudo and Renan Colucci and Sapun H. Parekh and Pol Besenius and Jasper J. Michels and Ulrike Kraft}, doi = {10.1002/advs.202502853}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502853}, shortjournal = {Adv. Sci.}, title = {Enhanced electrical performance and stretchability by plasticizer-facilitated PEDOT:PSS self-alignment}, volume = {12}, year = {2025}, }
• (2025). General screening rules and segmented optimization strategy for efficient thermoelectric devices validated by Mg3(Sb,Bi)2/Bi0.5Sb1.5Te3-GeTe module. ADVS, 12(27), 2502832. (www)

  @article{ , abstract = {Segmentation is a widely adopted strategy to enhance the efficiency of medium- and high-temperature thermoelectric devices by capitalizing on the distinct properties of materials across various temperature ranges. Establishing a highly compatible matching relationship is crucial for maximizing conversion efficiency. In this study, the concepts of materials’ compatibility factor and relative current density into the screening process are emphasized for universal adaptability. The effectiveness and practicality of the theoretical model for optimal segmented combinations are validated through COMSOL finite element simulations and experimental results. A segmented thermoelectric power generation device is constructed that integrates the environmentally friendly n-type Mg 3 (Sb,Bi) 2 with the optimal segmented pairing of Bi 0.5 Sb 1.5 Te 3 -GeTe. Notably, at a temperature difference of Δ T = 440 K, this device achieves a maximum conversion efficiency of 10.4% and a peak output power of 0.41 W. These findings provide a solid theoretical foundation for the development of efficient combinations of thermoelectric materials.}, archive = {J_ADVS}, author = {Kai-Yu Yang and Xiaoyuan Li and Yuanxin Jiang and Liangliang Wang and Kai Guo and Lei Miao and Junliang Chen and Jiye Zhang and Lin Li and Yusong Du and Guang-Hui Rao and Jun Luo and Jing-Tai Zhao}, doi = {10.1002/advs.202502832}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502832}, shortjournal = {Adv. Sci.}, title = {General screening rules and segmented optimization strategy for efficient thermoelectric devices validated by Mg3(Sb,Bi)2/Bi0.5Sb1.5Te3-GeTe module}, volume = {12}, year = {2025}, }
• (2025). Lewis Acid–Base synergistically enhancing practical composite electrolyte for fluoride-ion batteries at room temperature. ADVS, 12(27), 2502824. (www)

  @article{ , abstract = {Fluoride-ion batteries (FIBs) represent a potential “next-generation” electrochemical storage device, offering high energy density. However, the practical implementation of FIBs at room temperature is impeded by the limitations of currently available ceramic electrolytes. Here, a composite NH 4 HF 2 @PEO@β-PbSnF 4 electrolyte with both high conductivity of 10 −4 S cm −1 and wide electrochemical stability window (4.59 V vs Pb/PbF 2 ) at room temperature is fabricated. Field emission transmission electron microscope (FETEM) demonstrates the presence of a space charge region, which enhances the conductivity. Furthermore, 19 F NMR and density functional theory (DFT) calculations elucidate that the interaction between Sn 2+ (Lewis acid) and HF 2 − (Lewis base) induces significant modifications to the electronic structure, which critically contribute to the enhanced electrochemical stability window of the composite electrolyte. Integrating this promising electrolyte with high-voltage CuF 2 cathodes and Pb/PbF 2 anodes, a reversible coin cell with a discharge capacity of 143 mAh g −1 up to 50 cycles is demonstrated. The rational design of such composite electrolytes offers a pathway toward the practical application of FIBs at room temperature.}, archive = {J_ADVS}, author = {Hong Cui and Xiao Gao and Keyu Guo and Wu Liu and Bo Ouyang and Wenbin Yi}, doi = {10.1002/advs.202502824}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502824}, shortjournal = {Adv. Sci.}, title = {Lewis Acid–Base synergistically enhancing practical composite electrolyte for fluoride-ion batteries at room temperature}, volume = {12}, year = {2025}, }
• (2025). Suppressing colloidal quantum dot multimer fusion leads to high-performance InSb infrared photodetectors. ADVS, 12(27), 2502775. (www)

  @article{ , abstract = {Environmentally friendly InSb colloidal quantum dots (CQDs) short-wave infrared (SWIR) photodetectors feature characteristics of low-cost, high-volume scalability, CMOS integrability, and compliance with RoHS regulations, and hold great commercial potential. Yet, their performance falls short of commercially relevant specifications. In this work, it is posited that CQD fusion observed in these dots leads to the formation of band-tail trap states and it is further demonstrated that avoidance of such band-tail trap states is crucial for device performance. By doing so, InSb CQDs SWIR photodetectors are reported with compelling performance metrics, including a dark current of 4 µA cm −2 , EQE of ≈20% (at −1 V), a linear dynamic range over 140 dB and a response time of 90 ns. This represents a more than ten-fold reduction in dark current compared to previously report InSb CQD photodetectors in the SWIR range. The record high PLQY of 10% for InSb/InP CQDs taken together with the high EQE of the device at zero bias confirm the achievement of high-quality InSb CQDs through the suppression of band-tail trap states and passivation of surface defects.}, archive = {J_ADVS}, author = {Lucheng Peng and Yongjie Wang and Carmelita Rodà and Aditya Malla and Miguel Dosil and Debranjan Mandal and Gerasimos Konstantatos}, doi = {10.1002/advs.202502775}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502775}, shortjournal = {Adv. Sci.}, title = {Suppressing colloidal quantum dot multimer fusion leads to high-performance InSb infrared photodetectors}, volume = {12}, year = {2025}, }
• (2025). Living biotherapeutics using nanoparticles-armed cyanobacteria for boosting photodynamic-immunotherapy of cancer. ADVS, 12(27), 2502746. (www)

  @article{ , abstract = {The interdisciplinary development of synthetic biology and material sciences propels medicine into a new era. For cancer therapy, living biotherapeutics integrating functional living bacteria with nanomedicine are particularly interesting. The current study developed a living biotherapeutic platform integrating oxygen-self-supplying cyanobacteria with multifunctional prodrug nanoparticles to boost photodynamic immunotherapy. Generally, tetracarboxyl porphyrin is associated with cisplatin via a covalent self-assembly strategy into uniform prodrug-skeletal nanoparticles (ZnNCs). This helped encapsulate the antitumor drug dicumarol derivative (DicTBS). Later, these developed DicTBS-ZnNC nanoparticles helped arm the surface of cyanobacteria using electrostatic adsorption to yield living nanotherapeutics (Cyano@DicTBS-ZnNCs). Cyano@DicTBS-ZnNCs achieved a self-supply of nanoparticles and oxygen under 660 nm laser irradiation, producing PDT therapeutic effects. Furthermore, combining cisplatin and dicoumarol achieved synergistic anticancer effects. This approach also induced immunogenic cell death (ICD) and regulated the tumor microenvironment (TME). This promoted an immune-supportive environment to improve antitumor immune responses.}, archive = {J_ADVS}, author = {Zhengwei Xu and Mingsong Zang and Hui Li and Ruizhen Tian and Zherui Zhang and Wang Liu and Fei Xiao and Xuesha Yan and Yan Zhu and Canhong Zhu and Jiayun Xu and Shuangjiang Yu and Tingting Wang and Hongcheng Sun and Junqiu Liu}, doi = {10.1002/advs.202502746}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502746}, shortjournal = {Adv. Sci.}, title = {Living biotherapeutics using nanoparticles-armed cyanobacteria for boosting photodynamic-immunotherapy of cancer}, volume = {12}, year = {2025}, }
• (2025). Resonant spin amplification and accumulation in MAPbI3 single crystals. ADVS, 12(27), 2502735. (www)

  @article{ , abstract = {Quantum technologic and spintronic applications require reliable semiconducting materials that enable a significant, long-living spin polarization of electronic excitations and offer the ability to manipulate it optically in an external field. Due to the specifics of band structure and remarkable spin-dependent properties, the lead halide perovskite semiconductors are suitable candidates for that. Here, the carrier spin dynamics in a MAPbI 3 (MA = methylammonium) perovskite single crystal with thickness of 20 µm are studied by the time-resolved Kerr ellipticity technique at cryogenic temperatures. Long times of longitudinal electron spin relaxation T 1 = 30 ns and transverse electron spin dephasing ns are found. The spin dynamics lasting longer than the applied laser pulse repetition period give rise to spin accumulation effects. They are exploited through the resonant spin amplification, polarization recovery, and spin inertia techniques to study the electron and hole spin systems coupled with the nuclear spins. These results establish the lead halide perovskite semiconductors as suitable platform for quantum technologies relying on spin-dependent phenomena.}, archive = {J_ADVS}, author = {Erik Kirstein and Dmitri R. Yakovlev and Evgeny A. Zhukov and Nataliia E. Kopteva and Bekir Turedi and Maksym V. Kovalenko and Manfred Bayer}, doi = {10.1002/advs.202502735}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502735}, shortjournal = {Adv. Sci.}, title = {Resonant spin amplification and accumulation in MAPbI3 single crystals}, volume = {12}, year = {2025}, }
• (2025). Ultralow overpotential in rechargeable Li–CO2 batteries enabled by caesium phosphomolybdate as an effective redox catalyst. ADVS, 12(27), 2502553. (www)

  @article{ , abstract = {Rechargeable lithium-CO 2 batteries are emerging as attractive energy storage devices due to their potential for high capacity and efficient CO 2 reduction, making them promising candidates for post-lithium-ion batteries with high energy densities. However, their practical applications have been restricted by low reversibility, poor cycle life, and sluggish redox kinetics induced by the high potential required for decomposing the discharge product Li 2 CO 3 . Despite the various cathode catalysts explored, their application is often limited by availability, high cost, and complexity of synthesis. Herein, caesium phosphomolybdate (CPM) is synthesized through a facile and low-cost method. The Li‒CO 2 battery based on the CPM cathode demonstrates a high discharge capacity of 15 440 mAh g −1 at 50 mA g −1 with 97.3% coulombic efficiency. It further exhibits robust stability, operating effectively over 100 cycles at 50 mA g −1 with a capacity limitation of 500 mAh g −1 . Remarkably, the CPM catalyst yields a low overpotential of 0.67 V, surpassing most catalysts reported in prior research. This study reports, for the first time, the application of a Keggin-type polyoxometalate as a bifunctional redox catalyst, significantly improving the reversible cycling of rechargeable Li–CO 2 batteries.}, archive = {J_ADVS}, author = {Mahsa Masoudi and Neubi F. Xavier Jr and James Wright and Thomas M Roseveare and Steven Hinder and Vlad Stolojan and Qiong Cai and Robert C. T. Slade and Daniel Commandeur and Siddharth Gadkari}, doi = {10.1002/advs.202502553}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502553}, shortjournal = {Adv. Sci.}, title = {Ultralow overpotential in rechargeable Li–CO2 batteries enabled by caesium phosphomolybdate as an effective redox catalyst}, volume = {12}, year = {2025}, }
• (2025). Stable pincer Gold(III)-TADF emitters with extended Donor–Acceptor separation for efficient vacuum-deposited OLEDs with operational lifetime (LT95) up to 3831 h at 1000 cd m−2. ADVS, 12(27), 2502529. (www)

  @article{ , abstract = {Although gold-TADF (thermally activated delayed fluorescence) emitters have attractive prospects as next-generation practical OLED emitters, the performance of OLEDs utilizing gold(I)- and gold(III)-TADF emitters lags behind the requirements of practical applications, and device lifetime has become a bottleneck. Here, novel pincer gold(III)-TADF emitters that are easily fabricated with tunable donor and acceptor ligands are presented. These pincer gold(III)-TADF emitters exhibit an extended molecular π-distance along the transition dipole moment, resulting in a significant reduction in the electron exchange energy between the S 1 and T 1 excited states, thus narrowing the singlet–triplet energy gap (Δ E ST ). The combination of small Δ E ST and heavy-atom (Au, S) effect greatly enhances spin-flip dynamics and produces efficient TADF (photoluminescence quantum yields up to 90%) with high radiative decay rate constants ( k r up to 10 6 s −1 ), and short lifetimes ( τ less than 1.2 µs) in thin films at room temperature. Vacuum-deposited OLEDs based on these gold(III)-TADF emitters demonstrate impressive stability, achieving i) a high maximum external quantum efficiency (EQE max ) of up to 22.2%, and ii) a record- long operational lifetime (LT 95 ) of 3831 h at an initial luminance of 1000 cd m −2 . This excellent durability makes the pincer gold(III)-TADF emitter a promising and competitive alternative to iridium and platinum emitters for practical OLED applications.}, archive = {J_ADVS}, author = {Hui-Xing Shu and Shuo Xu and Wai-Pong To and Gang Cheng and Chi-Ming Che}, doi = {10.1002/advs.202502529}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502529}, shortjournal = {Adv. Sci.}, title = {Stable pincer Gold(III)-TADF emitters with extended Donor–Acceptor separation for efficient vacuum-deposited OLEDs with operational lifetime (LT95) up to 3831 h at 1000 cd m−2}, volume = {12}, year = {2025}, }
• (2025). DDX3 regulates the cap-independent translation of the japanese encephalitis virus via its interactions with PABP1 and the untranslated regions of the viral genome. ADVS, 12(27), 2502493. (www)

  @article{ , abstract = {The translation of global cellular proteins is almost completely repressed in cells with flavivirus infection, while viral translation remains efficient. The mechanisms of flaviviruses evade host translational shutoff are largely unknown. Here, it is found that Japanese encephalitis virus (JEV) can adopt cap-independent (CI) translation to escape the host translational shutoff. Furthermore, the elements DB2 and sHP-SL within 3′UTR are involved in the regulation of CI translation, which is conserved in the genus Orthoflavivirus . By RNA affinity purification and mass spectrometry analysis, cellular DEAD-box protein 3 (DDX3) and poly(A)-binding protein 1 (PABP1) are identified as key factors in regulating CI translation of JEV via their interactions with DB2 and sHP-SL RNA structures. Mechanistically, it is revealed that DDX3 binds to both 5′UTR and 3′UTR of the JEV genome to establish a closed-loop architecture and recruit eIF4G/eIF4A to form the DDX3/PABP1/eIF4G/eIF4A tetrameric complex via its interaction with PABP1, thereby recruiting the ribosomal 43S preinitiation complex (PIC) to the 5′-end of the JEV genome to start translation. These findings demonstrate a noncanonical translation strategy employed by JEV and further reveal the regulatory roles of DDX3 and PABP1 in this mechanism. These results expand the knowledge of the translation initiation regulation in flaviviruses under the state of host translational shutoff, which provides a conserved antiviral target against orthoflavivirus .}, archive = {J_ADVS}, author = {Chenxi Li and Linjie Zhang and Chenyang Tang and Xuan Chen and Jing Shi and Qingyu Li and Xue Jiao and Jinyao Guo and Bin Wang and Kefan Bu and Abdul Wahaab and Yuguo Yuan and Ming-an Sun and Yanhua Li}, doi = {10.1002/advs.202502493}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502493}, shortjournal = {Adv. Sci.}, title = {DDX3 regulates the cap-independent translation of the japanese encephalitis virus via its interactions with PABP1 and the untranslated regions of the viral genome}, volume = {12}, year = {2025}, }
• (2025). Suppressing mo-species leaching in MoOx/A-Ni3S2 cathode for stable anion exchange membrane water electrolysis at industrial-scale current density. ADVS, 12(27), 2502478. (www)

  @article{ , abstract = {The development of non-noble metal-based hydrogen evolving reaction (HER) electrocatalysts operating under high current density plays a critical role in the large-scale application of anion exchange membrane water electrolysis (AEM-WE). Herein, a porous and hybrid MoS 2 /Ni 3 S 2 is synthesized on nickel foam (NF) via a one-step hydrothermal method and studied its reconstruction process during alkaline HER conditions. Experimental results indicated that the MoS 2 underwent an oxidative dissolution followed by a dynamic equilibrium between dissolution and redeposition of the amorphous MoO x during HER. Meanwhile, S-vacancy-rich Ni 3 S 2 (A-Ni 3 S 2 ) is exposed and acts as the real active site for HER. The obtained MoO x /A-Ni 3 S 2 catalyst exhibited high catalytic performance in three-electrode systems and single-cell AEM-WE. Finally, for a long-term durability test in the AEM electrolyzer, a dry cathode method is applied to suppress the Mo species leaching from the MoO x /A-Ni 3 S 2 electrode. Remarkably, the device assembled by MoO x /A-Ni 3 S 2 as the cathode catalyst and NiFe as the anode catalyst demonstrated a high stability of 2500 h at 2 A cm −2 and 40 °C with a small aging rate of 30 µV h −1 .}, archive = {J_ADVS}, author = {Husileng Lee and Guoheng Ding and Linqin Wang and Yunxuan Ding and Tang Tang and Licheng Sun}, doi = {10.1002/advs.202502478}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502478}, shortjournal = {Adv. Sci.}, title = {Suppressing mo-species leaching in MoOx/A-Ni3S2 cathode for stable anion exchange membrane water electrolysis at industrial-scale current density}, volume = {12}, year = {2025}, }
• (2025). Tailored fluorescent Metal–Organic frameworks hybrid membrane sensor arrays: Simultaneous and selective quantification of multiple antibiotics. ADVS, 12(27), 2502452. (www)

  @article{ , abstract = {Sensor array offers significant potential for rapid, high-throughput antibiotic detection. However, cross-reactivity-based sensor arrays often lack accuracy, despite comprehensive data analysis; while traditional high-affinity-based sensors based on antibodies/aptamers frequently suffer from complicated design and poor robustness. Here, a filterable paper-based fluorescent metal–organic frameworks (MOFs) sensor array is developed for one-to-one recognition and quantification of multiple antibiotics. Three representative MOFs are designed to exceptional affinity and specificity for the target antibiotic. A filtration-assisted detection enhances sensitivity, achieving parts-per-billion (ppb)-level detection in mixed solutions. The proposed approach integrates recognition and signal generation, streamlined 10-min process. The robustness of the MOFs also enables direct detection in raw samples containing organic solvents, which is not achievable by conventional methods. Notably, the sensor array can be easily incorporated into a smartphone-based portable device, coupled with a user-friendly image analysis applet for one-step extraction and quantitative detection in chicken samples. Leveraging MOFs’ versatility, this method can be extended to simultaneously detect a broad range of antibiotics, offering the potential for universal, high-throughput accurate detection of various chemical targets.}, archive = {J_ADVS}, author = {Tongtong Ma and Qiao Huang and Lei Yuan and Shugang Yan and Yalin Mo and Yibin Ying and Yingchun Fu and Jinming Pan}, doi = {10.1002/advs.202502452}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502452}, shortjournal = {Adv. Sci.}, title = {Tailored fluorescent Metal–Organic frameworks hybrid membrane sensor arrays: Simultaneous and selective quantification of multiple antibiotics}, volume = {12}, year = {2025}, }
• (2025). Amino acid-sensing neurons in the anterior piriform cortex control brown adipose tissue thermogenesis. ADVS, 12(27), 2502421. (www)

  @article{ , abstract = {Amino acid sensing in the central nervous system plays a key role in regulating energy homeostasis. The anterior piriform cortex (APC) has been implicated in sensing amino acid deficiency and rapidly inducing an aversive response. However, the precise types of neurons involved and whether they possess additional metabolic regulatory functions remain to be elucidated. The study reveals that corticotropin-releasing hormone (CRH) neurons in the APC (APC CRH neurons) are activated by a leucine-deficient diet to modulate brown adipose tissue thermogenesis and that they regulate body temperature in response to leucine deprivation. The findings reveal that APC CRH neurons are sensitive to leucine-deprivation signaling, with general control nonderepressive-2 playing an essential role in enhancing their intrinsic excitability. Furthermore, APC CRH neurons project into the known hypothalamic thermoregulatory region of the lateral hypothalamus, and APC CRH –lateral hypothalamus circuits mediate leucine deprivation-induced thermogenesis. Additionally, it is observed that thermogenic regulation by APC CRH neurons contributes to the maintenance of body temperature under cold exposure. Collectively, the findings identify a population of leucine-sensing APC CRH neurons, and reveal the signals and circuits involved in their regulation of brown adipose tissue thermogenesis and their subsequent contribution to body temperature regulation and energy homeostasis.}, archive = {J_ADVS}, author = {Peixiang Luo and Kexin Tong and Yeting Gan and Min Tang and Yuguo Niu and Kan Liu and Shihong Ni and Shangming Wu and Xiaoxue Jiang and Haizhou Jiang and Fei Xiao and Shanghai Chen and Wei Lv and Xiaoying Li and Feixiang Yuan and Feifan Guo}, doi = {10.1002/advs.202502421}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502421}, shortjournal = {Adv. Sci.}, title = {Amino acid-sensing neurons in the anterior piriform cortex control brown adipose tissue thermogenesis}, volume = {12}, year = {2025}, }
• (2025). AuCu@CuO2 aerogels with H2O2/O2 self-supplying and quadruple enzyme-like activity for MRSA-infected diabetic wound management. ADVS, 12(27), 2502391. (www)

  @article{ , abstract = {Diabetic wound healing presents serious clinical challenges due to the unique wound microenvironment characterized by hyperglycemia, bacterial infection, excessive oxidative stress, and hypoxia. Herein, a copper peroxide (CuO 2 )-coated AuCu bimetallic aerogel is developed that exhibits quadruple enzyme-mimicking activity and H 2 O 2 /O 2 self-supplying to modulate the complex microenvironment of methicillin-resistant staphylococcus aureus (MRSA) -infected diabetic wounds. The AuCu@CuO 2 aerogels demonstrate favorable photothermal properties and mimic four enzyme-like activities: peroxidase-like activity for producing toxic reactive oxygen species; catalase-like activity for decomposing H 2 O 2 to release O 2 to relieve oxidative stress and hypoxia; glucose oxidase-like activity for reducing excessive blood glucose and glutathione peroxidase-like activity for balancing abnormal glutathione level. The CuO 2 coating facilitates a continuous and adequate in situ production of H 2 O 2 within the mildly acidic infection microenvironment, enabling excellent antibacterial activity and reduced blood glucose levels during the initial treatment of infected diabetic wounds. Furthermore, the engineered AuCu@CuO 2 aerogels not only scavenge elevated ROS during the inflammatory phase but also synergistically generate oxygen to promote wound healing. Overall, the AuCu@CuO 2 aerogelsmicroenvironment can be activated by the diabetic wound infection microenvironments, alleviating inflammation, reducing hypoxia, lowering blood glucose levels, and enhancing angiogenesis and collagen fiber accumulation, thereby significantly improving diabetic wound healing.}, archive = {J_ADVS}, author = {Xiaofeng Tan and Nanyun Lin and Sha Yang and Hongyu Gong and Minghui Wang and Na Li and Fen Liu and Dajun Rao and Yingying Wu and Jing Tang and Qinglai Yang}, doi = {10.1002/advs.202502391}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502391}, shortjournal = {Adv. Sci.}, title = {AuCu@CuO2 aerogels with H2O2/O2 self-supplying and quadruple enzyme-like activity for MRSA-infected diabetic wound management}, volume = {12}, year = {2025}, }
• (2025). Heterostructure of Fe3O4 confined in hierarchical porous carbon for interface-enhanced medical-grade H2O2 electrosynthesis. ADVS, 12(27), 2502388. (www)

  @article{ , abstract = {The electrocatalytic two-electron oxygen reduction reaction (2e − ORR) presents an environmentally sustainable approach to produce hydrogen peroxide (H 2 O 2 ). Heterostructures coupling non-noble transition metal oxides (TMOs) with carbon materials hold promise for 2e − ORR, but face challenges in controlling morphology, phase composition, and active centers. In this study, a hierarchically porous tremella-like heterojunction characterized by ultrafine cubic Fe 3 O 4 nanoparticles within the amorphous carbon (UFe 3 O 4 @HPAC) is obtained using the integrated platform of green Fe-based deep eutectic solvent via a two-step annealing process. UFe 3 O 4 @HPAC exhibits remarkable overall and intrinsic 2e − ORR activity, delivering 96% H 2 O 2 selectivity and a turnover frequency (TOF) of 67.5 s −1 . Notably, UFe 3 O 4 @HPAC possesses superior H 2 O 2 production capabilities, showing long-term stability of 100 h with a H 2 O 2 production rate of 8.1 g L −1 h −1 in flow-cell, while achieving various medical-grade H 2 O 2 concentrations (3.0–7.8 wt%). Additionally, integrating on-site H 2 O 2 production with electro-Fenton achieved rapid decomposition of contaminants. The unique heterostructure, with the synergistic effect of Fe 3 O 4 and amorphous carbon, enhances electronic conductivity. Moreover, the electronic redistribution at the interface of the heterostructure triggers the thermodynamically favorable multiple active sites of Fe and C centers for the 2e − ORR. This work offers a new perspective on transition metal-based materials for H 2 O 2 production.}, archive = {J_ADVS}, author = {Yanan Shi and Li-Li Zhang and Chongyang Wang and Shaohui Sun}, doi = {10.1002/advs.202502388}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502388}, shortjournal = {Adv. Sci.}, title = {Heterostructure of Fe3O4 confined in hierarchical porous carbon for interface-enhanced medical-grade H2O2 electrosynthesis}, volume = {12}, year = {2025}, }
• (2025). Capacity estimation and knee point prediction using electrochemical impedance spectroscopy for lithium metal battery degradation via machine learning. ADVS, 12(27), 2502336. (www)

  @article{ , abstract = {Lithium-metal batteries (LMBs) are emerging as a promising next-generation energy storage due to their exceptionally high energy density. However, accurately predicting their performance remains challenging because of the complex degradation mechanisms. In this study, a machine learning (ML) framework is proposed that combines electrochemical impedance spectroscopy (EIS) with the XGBoost algorithm to develop two predictive models: one for estimating capacity degradation and another for detecting the knee point (KP)—a critical inflection point in the degradation trajectory. SHapley Additive exPlanations (SHAP) analysis is employed to interpret feature importance, revealing that low-frequency imaginary impedance components—associated with diffusion-limited processes such as lithium depletion and accumulation—are most influential for capacity estimation. Conversely, high-frequency features related to charge transfer resistance play a dominant role in the KP detection. To reduce data complexity and improve model efficiency, the input by selecting specific frequency points based on SHAP values is further optimized. The optimized models exhibit comparable or improved accuracy compared to those using the whole EIS data and have reasonable performance on unseen test data. The findings highlight that EIS-based ML models can accurately forecast heaslth of LMBs, providing deeper insights into their aging processes and enhancing battery management strategies.}, archive = {J_ADVS}, author = {Qianli Si and Shoichi Matsuda and Yasunobu Ando and Toshiyuki Momma and Yoshitaka Tateyama}, doi = {10.1002/advs.202502336}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502336}, shortjournal = {Adv. Sci.}, title = {Capacity estimation and knee point prediction using electrochemical impedance spectroscopy for lithium metal battery degradation via machine learning}, volume = {12}, year = {2025}, }
• (2025). Structure and antigenicity of kaposi's sarcoma-associated herpesvirus glycoprotein b. ADVS, 12(27), 2502231. (www)

  @article{ , abstract = {Kaposi's sarcoma-associated herpesvirus (KSHV), a member of the human γ-herpesviruses family, exhibits extensive cellular tropism and is associated with Kaposi's sarcoma and various B-cell malignancies. Despite its clinical significance, no effective prophylactic vaccines or specific therapeutics are currently available to prevent or treat KSHV infection. Similar to other herpesviruses, KSHV depends on the envelope glycoprotein B (gB) for host receptor recognition and membrane fusion initiation, making gB a prime target for antiviral antibody or vaccine development. In this study, the high-resolution cryo-electron microscopy (cryo-EM) structure of KSHV gB is presented, revealing a unique trimeric conformation resembling the postfusion state observed in other herpesviruses. Additionally, the structure of the non-neutralizing monoclonal antibody 2C4 bound to KSHV gB domain IV is resolved. The comparative sequence and structure analyses reveal significant homology in neutralizing epitopes between KSHV and Epstein-Barr virus (EBV) gB, indicating a potential pathway for the development of broad-spectrum antiviral strategies. These findings provide a foundation for a deeper understanding of KSHV's infectious mechanism and pave the way for the creation of universal interventions against the human γ-herpesviruses.}, archive = {J_ADVS}, author = {Xin-Yan Fang and Cong Sun and Chu Xie and Bing-Zhen Cheng and Zheng-Zhou Lu and Ge-Xin Zhao and Sen-Fang Sui and Mu-Sheng Zeng and Zheng Liu}, doi = {10.1002/advs.202502231}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502231}, shortjournal = {Adv. Sci.}, title = {Structure and antigenicity of kaposi's sarcoma-associated herpesvirus glycoprotein b}, volume = {12}, year = {2025}, }
• (2025). Ligand engineering of co-n4 single-atom catalysts for highly-active and stable acidic oxygen evolution. ADVS, 12(27), 2502230. (www)

  @article{ , abstract = {The development of stable and efficient single-atom catalysts (SACs) for the oxygen evolution reaction (OER) in acidic media remains challenging. This work reports a novel NH 3 -assisted pyrolysis strategy to synthesize Co-N 4 SACs with controlled nitrogen coordination environments on crumpled graphene supports. The pyrrolic N 4 -coordinated Co sites demonstrate superior OER activity compared to their pyridinic counterparts, achieving an overpotential of 351 mV at 10 mA cm −2 in 0.5 m H 2 SO 4 . Combined density functional theory calculations and operando X-ray absorption spectroscopy reveal that the pyrrolic coordination environment facilitates enhanced OH − adsorption and subsequent OER kinetics due to its unique electronic structure and geometric flexibility. A multi-layered protective mechanism in the pyrrolic system enables exceptional stability during long-term acidic OER operation, stemming from higher defect formation energy of Co sites and strategic distribution of sacrificial nitrogen species in the graphene network. These findings provide fundamental insights into designing stable single-atom catalysts for challenging electrochemical applications.}, archive = {J_ADVS}, author = {Taeyoung Jeong and Kiwon Kim and Byung-Hyun Kim and Sang-Il Choi and Chang Hyuck Choi and Joonhee Kang and Myeongjin Kim}, doi = {10.1002/advs.202502230}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502230}, shortjournal = {Adv. Sci.}, title = {Ligand engineering of co-n4 single-atom catalysts for highly-active and stable acidic oxygen evolution}, volume = {12}, year = {2025}, }
• (2025). Direction-dependent conduction polarity in altermagnetic CrSb. ADVS, 12(27), 2502226. (www)

  @article{ , abstract = {CrSb has recently gained immense attention as an altermagnetic candidate. This work reports on the experimental observation of direction-dependent conduction polarity (DDCP) in altermagnetic CrSb through Hall and Seebeck thermopower measurements. Conduction is dominated by holes along the -axis and by electrons in the -plane of the hexagonal crystal of CrSb. Density functional theory (DFT) calculations indicate that DDCP in CrSb arises from a multicarrier mechanism, where electrons and holes living in distinct bands dominate conduction along different crystallographic directions. Furthermore, DFT predicts that DDCP exists within a narrow energy window near the Fermi level and is sensitive to small doping levels. This prediction is experimentally validated by the loss of DDCP in hole-doped Cr 0.98 V 0.02 Sb. These findings highlight the potential for tunable electronic behavior in CrSb, offering promising avenues for applications in devices that require both p-type and n-type functionalities within a single material.}, archive = {J_ADVS}, author = {Banik Rai and Krishnendu Patra and Satyabrata Bera and Sk Kalimuddin and Kakan Deb and Mintu Mondal and Priya Mahadevan and Nitesh Kumar}, doi = {10.1002/advs.202502226}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502226}, shortjournal = {Adv. Sci.}, title = {Direction-dependent conduction polarity in altermagnetic CrSb}, volume = {12}, year = {2025}, }
• (2025). TCMD: A high-throughput and rapid method for screening antimicrobial ingredients from renewable bio-based resources. ADVS, 12(27), 2502156. (www)

  @article{ , abstract = {Antibiotic resistance and pathogenic infections underscore the importance and urgency of novel control agent development. Bio-based products represent a rich reservoir of antimicrobial agents. However, traditional strategies for screening new active compounds are time-consuming, costly, and limited by accessible resources. Here, transcriptomic combinatorial molecular docking (TCMD), a novel method enabling fast identification of antimicrobial components in complex mixtures without requiring prior knowledge is proposed. Results show that, in eukaryotic microorganism systems, TCMD demonstrates superior performances in screening antifungal compounds within hydrothermal liquefaction aqueous. The high accuracy is confirmed by molecular dynamics simulation, antifungal experiments, and RT-qPCR (reverse transcription real-time quantitative polymerase chain reaction) analysis. Furthermore, TCMD exhibits cross-system applicability, as evidenced by successful antibacterial substances screening in prokaryotic systems using plant essential oil and traditional Chinese medicine from previous studies. Compared to conventional approaches, TCMD is estimated to be 3–20 times faster and ≈10 times more cost-effective, while maintaining high-throughput capacity for analyzing thousands of compounds simultaneously. These demonstrate that TCMD is a rapid, precise, and flexible method for antimicrobial compound discovery, significantly accelerating the development of new antibacterial agents.}, archive = {J_ADVS}, author = {Yongdong Xu and Yueyao Wang and Yongming Chen and Yunxia Wang and Shicheng Zhang and Gang Luo and Fuhao Cui and Taisheng Du and Zhidan Liu}, doi = {10.1002/advs.202502156}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502156}, shortjournal = {Adv. Sci.}, title = {TCMD: A high-throughput and rapid method for screening antimicrobial ingredients from renewable bio-based resources}, volume = {12}, year = {2025}, }
• (2025). Transforming the poison effects of water vapor into benefits over adjustable dual acid sites for stable plasma-catalysis. ADVS, 12(27), 2502123. (www)

  @article{ , abstract = {Developing a new strategy to address water vapor poisoning is crucial for catalysts in real-working conditions. Except for the traditional thinking of resistance enhancement, a reverse idea is proposed herein of utilizing the inevitable H 2 O, converting it to active ·OH to enhance the overall performance, with the help of O 3 and high energy electrons (e*) in plasma. Dual active sites of Lewis acid (Y 3+ ) and Mn on Y x Mn y O x+2y catalyst promote the co-adsorption of H 2 O and O 3 , and the dissociation of H 2 O to surface hydroxyl species (*OH). A new OH-accompanied pathway for O 3 decomposition is formed and a new intermediate species (*OOH) with a lower energy barrier (0.77 eV lower than traditional *O 2 2− ) is detected, in which e* in plasma can further accelerate its desorption. Thereafter, abundant active ·OH are generated and work for pollutants degradation, achieving 99.78% ethyl acetate (EA) degradation and 97.36% mineralization rate on the surface of YMO (1:2) under humid environment, with excellent long-term stability. The changed activation site of C─O bond in EA, different by-products, and reaction pathways are also analyzed. This active species regulation strategy transforms the traditional poison effects of water vapor into great benefits, paving the way for broader catalyst applications free of water vapor.}, archive = {J_ADVS}, author = {Si Chen and Sibo Zhang and Lu Fang and Yan Yang and Chenyuan Zhu and Xinyi Dai and Zhengjun Gong and Fan Dong}, doi = {10.1002/advs.202502123}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502123}, shortjournal = {Adv. Sci.}, title = {Transforming the poison effects of water vapor into benefits over adjustable dual acid sites for stable plasma-catalysis}, volume = {12}, year = {2025}, }
• (2025). High-speed slot-die coating with donor-priority rapid aggregation kinetics for improved morphology and efficiency in ecofriendly organic solar cells. ADVS, 12(27), 2502077. (www)

  @article{ , abstract = {Solution-processable organic solar cells (OSCs) represent a promising renewable photovoltaic technology with significant potential for eco-compatible production. While high power conversion efficiencies (PCEs) have been achieved in OSCs, scaling this technology for high-throughput manufacturing remains challenging. Key reason lies in the lack of efficient control strategies for the complex and long-duration morphology evolution during high-speed coating process with ecofriendly solvents. Here, a donor-priority rapid aggregation process (DP-RAP) scheme is proposed to solve this issue by adjusting the aggregation kinetics of donor and acceptor components. DP-RAP enables blends with a nanoscale fiber network structure and favorable crystallinity, which contributes to balanced carrier transport and reduced recombination losses. As a result, the PCE is improved from 14.3% (reference) to 17.4% (DP-RAP) for ultra-high speed coated PM6:BTP-eC9 devices in atmosphere, which is one of the highest values for non-halogenated solvent-processed solar cells at coating speeds of 500 mm s −1 . Moreover, the DP-RAP based devices remain a stable PCE of approximately 17.4% across a broad range of coating speeds (20–500 mm s −1 ), illustrating its tolerance to the varied manufacturing conditions. This work highlights a promising avenue for the high-speed, ecofriendly production of efficient OSCs, pushing the boundaries of practical manufacturing in renewable energy technologies.}, archive = {J_ADVS}, author = {Zhaozhao Bi and Baohua Wu and Ke Wang and Jingwei Xue and Chang Liu and Lingxiao Tang and Ke Zhou and Long Jiang and Wei Ma}, doi = {10.1002/advs.202502077}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502077}, shortjournal = {Adv. Sci.}, title = {High-speed slot-die coating with donor-priority rapid aggregation kinetics for improved morphology and efficiency in ecofriendly organic solar cells}, volume = {12}, year = {2025}, }
• (2025). Reconstructing three-dimensional optical anisotropy with tomographic müller-polarimetric microscopy. ADVS, 12(27), 2502075. (www)

  @article{ , abstract = {Most visible light imaging methods using polarization to obtain ultrastructure information are limited to 2D analysis or require demanding phase measurements to be extended to 3D. A novel 3D polarized light imaging technique based on Müller-matrix formulations is introduced which numerically reconstructs 3D optical birefringence, that is anisotropic refractive indices and optical axis orientation, in each volumetric unit of sample. The new method is demonstrated, tomographic Müller-polarimetric microscopy, in simulation and using experimental data of 3D macroscopic sample of human trabecular bone sample, where the local main orientation of nanoscale collagen fibers is extracted with a resolution of ≈ 20 µm. Tomographic Müller-polarimetric microscopy offers a low-cost and experimentally simple imaging approach to access the ultrastructure which is not directly resolvable, in a wide range of biological and composite materials.}, archive = {J_ADVS}, author = {Yang Chen and Arthur Baroni and Torne Tänzer and Leonard Nielsen and Marianne Liebi}, doi = {10.1002/advs.202502075}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2502075}, shortjournal = {Adv. Sci.}, title = {Reconstructing three-dimensional optical anisotropy with tomographic müller-polarimetric microscopy}, volume = {12}, year = {2025}, }
• (2025). Potent cross-neutralizing antibodies reveal vulnerabilities of henipavirus fusion glycoprotein. ADVS, 12(27), 2501996. (www)

  @article{ , abstract = {Hendra and Nipah viruses (HNVs), zoonotic paramyxoviruses with >50% case fatality rates, cause fatal encephalitis and respiratory disease, yet lack approved therapies. Here, nine rhesus-derived monoclonal antibodies (mAbs) targeting the fusion glycoprotein (F) prefusion conformation are developed. Four mAbs exhibit first-rate cross-neutralization against HNVs, with two showing synergistic potency when combined with attachment glycoprotein (G)-specific mAbs. Single-dose administration of mAbs confers robust protection against lethal Nipah virus challenge in hamsters. Structural insights reveal that 8 of the 9 potent mAbs adopt a human IGHV4-59-like framework with protruding CDRH3 loops, forming pushpin-shaped paratopes that stabilize the prefusion F-trimer by occupying vulnerable interprotomer cavities. Systematic mutational profiling identifies 14 prefusion-locking residues within the F ectodomain, classified as i) structural linchpins governing fusogenicity or ii) immunodominant hotspots targeted by cross-neutralizing mAbs. This work delivers promising therapeutic candidates against HNVs and provides blueprints for the rational design of antibodies and vaccines targeting viral fusion machinery.}, archive = {J_ADVS}, author = {Yi Ren and Pengfei Fan and Xinghai Zhang and Ting Fang and Zhengshan Chen and Yanfeng Yao and Xiangyang Chi and Guanying Zhang and Xiaofan Zhao and Bingjie Sun and Fangxu Li and Zixuan Liu and Zhenwei Song and Baoyue Zhang and Cheng Peng and Entao Li and Yilong Yang and Jianmin Li and Sandra Chiu and Changming Yu}, doi = {10.1002/advs.202501996}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501996}, shortjournal = {Adv. Sci.}, title = {Potent cross-neutralizing antibodies reveal vulnerabilities of henipavirus fusion glycoprotein}, volume = {12}, year = {2025}, }
• (2025). A nanostructured ru-mn-nb alloy with oxygen-enriched boundaries for ampere-level hydrogen evolution. ADVS, 12(27), 2501976. (www)

  @article{ , abstract = {Development of active and cost-effective electrocatalysts to substitute platinum-based catalysts in alkaline hydrogen evolution reactions (HERs) remains a challenge. The synergistic effect between different elements in alloy catalysts can regulate electronic structure and thereby provide an abundance of catalytic sites for reactions. Thus, alloy catalysts are suitable candidates for future energy applications. Conventional methods for enhancing the performance of alloy catalysts have mainly focused on element composition and thus have often neglected to examine catalyst design. In this paper, a ruthenium–manganese–niobium alloy catalyst (Ru 62 Mn12Nb 21 O 5 ) is reported with a supra-nanocrystalline dual-phase structure that is fabricated through combinatorial magnetron co-sputtering at ambient temperatures. The induced crystal–crystal heterostructure of Ru 62 Mn 12 Nb 21 O 5 reduced system energy, thereby achieving balance between stability and catalytic activity. Ru 62 Mn 12 Nb 21 O 5 exhibited excellent HER performance, as demonstrated by low HER overpotential (18 mV at 10 mA cm −2 ) and robust stability (300 h at 1.2 A cm −2 ). Moreover, oxygen-rich interfaces in Ru 62 Mn 12 Nb 21 O 5 enhanced charge transfer and the kinetics of water dissociation as well as optimized hydrogen adsorption/desorption processes, thus boosting HER performance. The crystal–crystal heterostructure and oxygen-rich interfaces in Ru 62 Mn 12 Nb 21 O 5 are induced by its dual-phase nanocrystalline structure, which represents a new structural design for enhancing the performance of catalysts for sustainable energy development.}, archive = {J_ADVS}, author = {Jie Li and Xue Wang and Jun Yu and Kai Xu and Zhe Jia and Hongkun Li and Lei Ren and Yiyuan Yang and Keke Chang and Yangyang Li and Xiangfa Liu and Jian Lu and Sida Liu}, doi = {10.1002/advs.202501976}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501976}, shortjournal = {Adv. Sci.}, title = {A nanostructured ru-mn-nb alloy with oxygen-enriched boundaries for ampere-level hydrogen evolution}, volume = {12}, year = {2025}, }
• (2025). Activity-selectivity trends in electrochemical urea synthesis: Co-reduction of CO2 and nitrates over single-site catalysts. ADVS, 12(27), 2501882. (www)

  @article{ , abstract = {Electrochemical co-reduction of carbon dioxide and nitrates (CO 2 NO 3 RR) holds promise for sustainable urea production. However, the sluggish kinetics of the sixteen-electron transfer and unclear mechanistic understanding strongly impede its development. Here, combined experimental and computational approaches are employed to screen a series of metal phthalocyanine as model catalysts (MPcs, M = Zn, Co, Ni, Cu, and Fe) to uncover the activity-selectivity trends in electrochemical CO 2 NO 3 RR. The theoretical simulations reveal that the thermodynamics of urea synthesis is significantly influenced by key intermediates, where the enhanced adsorption of *HOOCNO, coupled with reduced adsorptions of *N and *COOH, and moderate adsorption of *H 2 O, can significantly promote the urea production. ΔG *HOOCNO −ΔG *N −ΔG *COOH +ΔG *H2O as a potential descriptor is proposed for predicting the efficiency of CO 2 NO 3 RR toward urea formation. The findings provide systematic guidance for the future design of high-efficiency catalysts for urea electrosynthesis, addressing a crucial need for sustainable nitrogen fixation.}, archive = {J_ADVS}, author = {Qinglan Zhao and Yushen Liu and Yuan Zhang and Shangqian Zhu and Hongming Xu and Mohammad Farhadpour and Fei Xiao and Minghui Xing and Dapeng Cao and Xueping Qin and Tejs Vegge and Minhua Shao}, doi = {10.1002/advs.202501882}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501882}, shortjournal = {Adv. Sci.}, title = {Activity-selectivity trends in electrochemical urea synthesis: Co-reduction of CO2 and nitrates over single-site catalysts}, volume = {12}, year = {2025}, }
• (2025). Trimerization of 1,2-diaminocyclohexane catalyzed by a Metal–Organic cage tandem catalyst with dual biomimetic active sites. ADVS, 12(27), 2501872. (www)

  @article{ , abstract = {Cascade reactions that form multiple chemical bonds in one synthetic step are important for the synthesis of complex molecules. Molecular catalysts for cascade reactions generally require two or more catalytic centers, yet anchoring distinct catalytic centers onto a single molecular catalyst remains extremely challenging. Here a metal–organic cage (MOC) [(ClO 4 ) 2 @Zn 20 (L) 8 (HCO 2 ) 6 (OH) 6 (H 2 O) 8 ] 2+ ( Zn 20 -MOC ) (H 3 L = tris(2-benzimidazolylmethyl)amine) carrying dual biomimetic active sites is reported, i.e. mononuclear {Zn II (L)(H 2 O)} and dinuclear {L 2 Zn II (CHO 2 )(OH)Zn II L 2 }. The two active sites play different roles in the catalytic cascade trimerization of 1,2-diaminocyclohexane 1 ), which produces hexadecahydro-5a,11a-butanoquinoxalino[2,3-b]quinoxaline 2 ) with a yield of ≈71.32%. It is find that the mononuclear {Zn II (L)(H 2 O)} site catalyzes the dimerization reaction of 1 , yielding an intermediate product 1,2,3,4,4a,6,7,8,9,10a-decahydrophenazine ( inter. 4 ). Further reaction between 1 and inter. 4 to form the final product must be catalyzed by the dinuclear {L 2 Zn II (HCO 2 )(OH)Zn II L 2 } site. This work not only provides a new approach to designing catalysts for cascade reactions, but also develops a unique synthetic strategy for the trimerization of 1,2-diaminocyclohexane, a process that has been unexplored until now.}, archive = {J_ADVS}, author = {Xiao-Jun Chai and Zhu Zhuo and Zi-Ang Nan and Shiqiang Mu and Zhong-Yu Peng and Ting Chen and Wei Wang and Li-Feng Lin and Xi Meng and Mao-Chun Hong and You-Gui Huang}, doi = {10.1002/advs.202501872}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501872}, shortjournal = {Adv. Sci.}, title = {Trimerization of 1,2-diaminocyclohexane catalyzed by a Metal–Organic cage tandem catalyst with dual biomimetic active sites}, volume = {12}, year = {2025}, }
• (2025). Respiration drives dynamic Metal–Organic framework for smart photoresponse to volatile toxic vapors and their photodynamic sterilization. ADVS, 12(27), 2501824. (www)

  @article{ , abstract = {Using aggregation-induced emission luminous (AIEgens) containing dynamic molecular rotor structures as linkers to construct flexible smart luminescent metal–organic frameworks (MOFs) has become a transformative approach to constructing artificial intelligence color-changing materials. Herein, 4′,4″,4′″,4″″-(ethene-1,1,2,2-tetrayl)tetrabiphenyl-4-carboxylic acid (H 4 TPPE) is selected as a linker, and octahedral Zr 6 O 4 (OH) 8 (H 2 O) 4 cluster are used as secondary building unit (SBU) to construct the first smart luminescent MOF (Zr-TPE-MOF) that can be driven by CH 2 Cl 2 or CH 3 COOH vapor for respiration. It is worth noting that Zr-TPE-MOF can absorb trace amounts of CH 2 Cl 2 or CH 3 COOH vapor into the pores through respiration and shows a blue shift of the emission wavelength up to 479 nm and an increase of emission intensity by nearly three times. In addition, the thermochromic behavior of Zr-TPE-MOF is not obvious in the temperature range of 80–350 K, but it has obvious thermofluorochromics behavior in the temperature range of 350–470 K. Zr-TPE-MOF showed highly sensitive and visualized smart photoresponse to the highly toxic Cr 2 O 7 2− , with a detection limit as low as 7.49 µ m . Benefiting from the porous framework structure and organic–inorganic hybrid characteristics of Zr-TPE-MOF, it has excellent ROS generation ability and has excellent application prospects in photodynamic sterilization and rapid degradation of colored dyes.}, archive = {J_ADVS}, author = {Yun-Lan Li and Hai-Ling Wang and Ju-Fen Ai and Guan-Huang Zhang and Hua-Hong Zou and Fu-Pei Liang and Zhong-Hong Zhu}, doi = {10.1002/advs.202501824}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501824}, shortjournal = {Adv. Sci.}, title = {Respiration drives dynamic Metal–Organic framework for smart photoresponse to volatile toxic vapors and their photodynamic sterilization}, volume = {12}, year = {2025}, }
• (2025). Colorectal cancer Cells–Derived exosomal PIK3CA mutation DNA promotes tumor metastasis by activating fibroblast and affecting tumor metastatic microenvironment. ADVS, 12(27), 2501792. (www)

  @article{ , abstract = {Exosomes participate in the formation of the tumor metastatic microenvironment (TME) by delivering tumor-specific substances. However, current studies mostly focus on exosomal RNA and proteins and lack an in-depth exploration of exosomal DNA. It is discovered that PIK3CA H1047R mutant DNA in colorectal cancer (CRC) cell-derived exosomes can be delivered into recipient fibroblasts, where they are transcribed and translated, ultimately leading to the activation of fibroblasts into cancer-associated fibroblasts (CAFs) through interaction with the endogenous P85 regulatory subunit of the phosphatidylinositol 3-kinase (PI3K) pathway. CAFs have facilitated tumor cell migration in vitro and promote lung metastasis in vivo by secreting elevated levels of IL6. Additionally, the PIK3CA H1047R mutation is detected in CAFs at both the primary and metastatic sites, suggesting that it may play a role in promoting metastasis by influencing the TME. Moreover, patients with CRC harboring the PIK3CA H1047R mutation and exhibiting elevated levels of IL6 are significantly more likely to metastasize. These findings suggest that the simultaneous detection of serum-derived exosomal PIK3CA H1047R mutation and serum IL6 secretion may serve as a promising diagnostic and prognostic tool for CRC and simultaneous targeting of PIK3CA H1047R mutation and IL6 may serve as a novel approach for the treatment of CRC.}, archive = {J_ADVS}, author = {Rui Wang and Wanming Li and Yuqiong Lv and Wei Ba and Ying Jiang and Xiaoshuai Li and Jin Fang}, doi = {10.1002/advs.202501792}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501792}, shortjournal = {Adv. Sci.}, title = {Colorectal cancer Cells–Derived exosomal PIK3CA mutation DNA promotes tumor metastasis by activating fibroblast and affecting tumor metastatic microenvironment}, volume = {12}, year = {2025}, }
• (2025). PP1A modulates the efficacy of lenvatinib plus ICIs therapy by inhibiting ferroptosis in hepatocellular carcinoma. ADVS, 12(27), 2501730. (www)

  @article{ , abstract = {Advanced hepatocellular carcinoma (HCC) is characterized by poor prognosis, primarily due to limited therapeutic options and resistance to treatment. Although the combination of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) has shown promising potential, the underlying mechanisms remain inadequately understood. Here, serine/threonine-specific protein phosphatase (PP1A) is upregulated in Lenvatinib-resistant HCC cells and correlates with poor prognosis. Functional experiments revealed that PP1A promotes HCC progression both in vitro and in vivo. Transcriptomic analysis and ferroptosis metabolite profiling (e.g., ROS, Fe 2 ⁺, lipid-ROS, and GSH) demonstrated that PP1A inhibits Lenvatinib-induced ferroptosis by dephosphorylating Keap1 at site 104. This disruption of the Keap1-Nrf2 interaction enhances the transcription of ferroptosis-related markers and immune checkpoint PD-L1. Notably, single-cell sequencing and co-culture experiments revealed that PP1A knockdown alleviates T cell exhaustion and immune evasion, thereby improving antitumor immunity. In vivo experiments further demonstrated that PP1A knockdown significantly enhances the efficacy of Lenvatinib-ICIs combination therapy. Overall, our findings highlight PP1A as a critical regulator of ferroptosis and antitumor immunity, suggesting its potential as a predictive biomarker and therapeutic target for improving outcomes in advanced HCC.}, archive = {J_ADVS}, author = {Jitong Zhou and Meng Gao and Shikun Zhang and Wing-Wa Guo and Wenzhi He and Minghe Zhang and Xi Chen and Cairang Dongzhi and Xiaomian Li and Yufeng Yuan and Weijie Ma}, doi = {10.1002/advs.202501730}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501730}, shortjournal = {Adv. Sci.}, title = {PP1A modulates the efficacy of lenvatinib plus ICIs therapy by inhibiting ferroptosis in hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). High specific strength eutectic high-entropy alloy: Collaborative effects of TRIP, TWIP, and nanoprecipitation. ADVS, 12(27), 2501703. (www)

  @article{ , abstract = {Eutectic high-entropy alloys (EHEAs), characterized by their combination of hard and ductile phases, hold broad application prospects in terms of mechanical properties. However, the current performance of these alloys is not satisfactory. Herein, a new design approach is presented for EHEAs, focusing on precise composition regulation of each phase in the dual-phase alloy. Hierarchically heterogeneous microstructure and integrating various strengthening mechanisms is successfully introduced such as phase transformation, twinning, and nanoprecipitates (NPs) into each single system. Finally, the overall strength and ductility are effectively enhanced. Specifically, the ultimate tensile strength is 1571 MPa, the uniform elongation is 22%, and the maximum strength can reach 2045MPa. Notably, the high Al content in the EHEA effectively reduces its density, resulting in the maximum specific ultimate tensile strength of 273 MPa cm 3 g −1 in HEAs. The multi-mechanism assisted strengthening (MMAS) strategy is expected to provide guidance for the design of dual-phase alloys like EHEAs in the future.}, archive = {J_ADVS}, author = {Z. Q. Wang and X. T. Li and Z. J. Zhang and Z. F. Zhang}, doi = {10.1002/advs.202501703}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501703}, shortjournal = {Adv. Sci.}, title = {High specific strength eutectic high-entropy alloy: Collaborative effects of TRIP, TWIP, and nanoprecipitation}, volume = {12}, year = {2025}, }
• (2025). Electronic structure of kramers nodal-line semimetal YAuGe and anomalous hall effect induced by magnetic rare-earth substitution. ADVS, 12(27), 2501669. (www)

  @article{ , abstract = {Nodal-line semimetals are a class of topological materials hosting one dimensional lines of band degeneracy. Kramers nodal-line (KNL) metals/semimetals have recently been theoretically recognized as a class of topological states inherent to all non-centrosymmetric achiral crystal lattices. The electronic structure of candidate KNL semimetal YAuGe is investigated by angle-resolved photoemission spectroscopy (ARPES) and quantum oscillations as well as by density functional theory (DFT) calculations. DFT has revealed that YAuGe hosts KNLs on the Γ-A-L-M plane of the Brillouin zone, that are protected by the time reversal and mirror-inversion symmetries. Through ARPES and quantum oscillations, signatures of hole bands enclosing the Γ point are identified, and the observed splitting of quantum oscillation frequency with angle is attributed to spin-orbit-coupling-induced band splitting away from the KNLs. Furthermore, it is shown that the degeneracy of the nodal lines along the Γ-A line is lifted by the time-reversal-symmetry breaking when the Y is substituted by magnetic R ions ( R = rare earth). This becomes a source of Berry curvature and contributes to the anomalous Hall effect in magnetic R AuGe. These findings establish R AuGe as a new class of KNL semimetals offering significant potential for engineering of anomalous magnetotransport properties via magnetic rare-earth substitution.}, archive = {J_ADVS}, author = {Takashi Kurumaji and Jorge I. Facio and Natsuki Mitsuishi and Shusaku Imajo and Masaki Gen and Motoi Kimata and Linda Ye and David Graf and Masato Sakano and Miho Kitamura and Kohei Yamagami and Kyoko Ishizaka and Koichi Kindo and Taka-hisa Arima}, doi = {10.1002/advs.202501669}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501669}, shortjournal = {Adv. Sci.}, title = {Electronic structure of kramers nodal-line semimetal YAuGe and anomalous hall effect induced by magnetic rare-earth substitution}, volume = {12}, year = {2025}, }
• (2025). Reversal of stress-induced PIEZO1 elevation with mechanically adapted epicardial patch for myocardial infarction treatment. ADVS, 12(27), 2501663. (www)

  @article{ , abstract = {Elevated expression of the mechanosensitive ion channel PIEZO1 in response to abnormal mechanical stimuli is implicated in many diseases, including myocardial infarction (MI). However, no effective strategy is currently available to normalize PIEZO1 expression for disease management. This study investigates the therapeutic potential of mechanically adapted cardiac patches in reversing PIEZO1 elevation and treating MI. Increased mechanical stress and PIEZO1 upregulation are observed in ischemic cardiomyopathy myocardium. Using finite element analysis, elastomeric patches are designed and applied on MI rats to reduce left ventricular (LV) wall stress and mitigate LV remodeling. Molecular analysis reveals that patch treatment suppresses stress-induced chromatin opening of the Piezo1 promoter, reversing PIEZO1 elevation and restoring heart contraction gene expression. The patch's therapeutic benefits correlate with the reversal of PIEZO1 elevation is further validated in a porcine model. Notably, constant high expression of endogenous PIEZO1 partially blocks the patch's therapeutic effects, confirming that the mechanism of patch treatment involves reversing PIEZO1 expression, in addition to providing physical support. In conclusion, cardiac patches reduce LV wall stress, preserving cardiac function and geometry by both physically supporting and biologically reversing PIEZO1 expression, highlighting the potential of medical devices in normalizing PIEZO1 expression and treating related diseases.}, archive = {J_ADVS}, author = {Yuwen Lu and Sibo Jiang and Ting Shen and Yuan Zhang and Chengbin He and Yun Gao and Liyin Shen and Qiao Jin and Yuting Zhao and Ping Liang and Chaochen Wang and Hongjie Hu and Jin He and Kaicheng Deng and Shuo Wang and Yunhe Chen and Jun Ling and Yang Zhu and Lenan Zhuang}, doi = {10.1002/advs.202501663}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501663}, shortjournal = {Adv. Sci.}, title = {Reversal of stress-induced PIEZO1 elevation with mechanically adapted epicardial patch for myocardial infarction treatment}, volume = {12}, year = {2025}, }
• (2025). Observation of optical precursor in time-energy-entangled w triphotons. ADVS, 12(27), 2501626. (www)

  @article{ , abstract = {In quantum communication and quantum computation, adding each entangled photon leads to an exponential increase in communication and computational capabilities. Utilizing a fifth-order nonlinear process, narrow-band non-Gaussian W-triphotons are experimentally generated through the spontaneous six -wave mixing (SSWM), but the manipulation of such entangled state in the group delay regime is still lacked. For the first time, the observation of optical precursors at the triphoton level is reported through the SSWM process. By appropriately adjusting the optical depth, optical precursors are effectively separated from the main wave through utilizing the slow-light effect to manipulate the triphoton temporal correlations in the group delay regime. In biphoton and conditional two-photon, the intensity ratio between the precursor and the main wave is tunable by adjusting the detuning and power of the laser. These pivotal breakthroughs mark a significant advancement in the study of optical precursors and open new possibilities for their application in quantum technologies.}, archive = {J_ADVS}, author = {Zhou Feng and Rui Zhuang and Sinong Liu and Guobin Liu and Kangkang Li and Yanpeng Zhang}, doi = {10.1002/advs.202501626}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501626}, shortjournal = {Adv. Sci.}, title = {Observation of optical precursor in time-energy-entangled w triphotons}, volume = {12}, year = {2025}, }
• (2025). Breaking the recycling bottleneck of thermosets via bio-tailoring technology. ADVS, 12(27), 2501617. (www)

  @article{ , abstract = {Thermosets present significant recycling challenges due to irreversible chemical crosslinking, resulting in resource waste and environmental pollution. This paper introduces a new strategy for designing thermosets with excellent recycling properties driven by Bio-Tailoring technology, achieving amazing green sustainable development. These thermosets are a class of infusible and insoluble polymers owing to chemical crosslinking. The indole groups in the cross-linked network can be accurately identified and tailored by microorganisms, giving rise to the cross-linked network being tailored into new linear polymers and small molecule segments, named the Bio-Tailoring technology. Linear polymers can be used as a new plastic packaging material that involves high transparency and appreciable mechanical properties. Meanwhile, the cross-linked small molecule moiety is a fluorescent functional unit with a unique push-pull electronic structure that leads to color-changing under external stimulation and can be applied to anti-counterfeiting. Overall, this strategy provides an innovative solution for the sustainable recycling of thermosets and opens a new path for the environmental transformation of the plastics industry.}, archive = {J_ADVS}, author = {Jinping Yu and Huan Wang and Yang Xu and Boutrous Wemegah and Yang Lan and Jing Li and Li Yang and Guanjun Chang}, doi = {10.1002/advs.202501617}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501617}, shortjournal = {Adv. Sci.}, title = {Breaking the recycling bottleneck of thermosets via bio-tailoring technology}, volume = {12}, year = {2025}, }
• (2025). Fn14 controls the SIRT2-mediated deacetylation of slug to inhibit the metastasis of epithelial ovarian cancer. ADVS, 12(27), 2501552. (www)

  @article{ , abstract = {Metastatic spread of cancer is the leading cause of death in patients with epithelial ovarian cancer (EOC), and elucidation of the molecular mechanisms underlying this process is a major focus of cancer research. Fibroblast growth factor-inducible 14 (Fn14) has been shown to regulate wound repair, inflammation, angiogenesis, and chemoresistance, but its functional role in metastasis in EOC is still unknown. Here it is reported that Fn14 is identified as a cancer metastasis suppressor that inhibits the migratory and invasive potential of EOC cells by down-regulating epithelial-mesenchymal transition (EMT). Mechanistically, it is identified that Fn14 promotes acetylation-dependent protein degradation of Slug, a key transcriptional factor associated with EMT. The deacetylase Sirtuin 2 (SIRT2) has been reported to be involved in the deacetylation of Slug protein to stabilize it and then prevent its degradation in the nucleus. The results showed that Fn14 alters the subcellular localization of (SIRT2) by interacting with SIRT2, leading to reduced SIRT2 shuttling into the nucleus and subsequently promoting the acetylated degradation of Slug. Collectively, the work has demonstrated for the first time that Fn14 inhibits EOC metastasis by regulating SIRT2-mediated Slug deacetylation, providing a new perspective and method for the development of future novel therapeutic strategies for the treatment of EOC metastasis.}, archive = {J_ADVS}, author = {Anyue Wu and Shengze Li and Chunyang Feng and Ruiju He and Ruolan Wu and Zhijun Hu and Jinhua Huang and Wenjing Wang and Lei Huang and Lihua Qiu}, doi = {10.1002/advs.202501552}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501552}, shortjournal = {Adv. Sci.}, title = {Fn14 controls the SIRT2-mediated deacetylation of slug to inhibit the metastasis of epithelial ovarian cancer}, volume = {12}, year = {2025}, }
• (2025). All-in-one flexible MXene/PET films via scalable scanning centrifugal casting for high transparency and ultra-wide multispectral electromagnetic responses. ADVS, 12(27), 2501540. (www)

  @article{ , abstract = {Highly integrated multifunctional materials are crucial for the development of next-generation aircraft and electronic communication devices. In this study, a novel ultra-thin MXene film with high optical transparency and broad multispectral electromagnetic responses is first fabricated using the scanning centrifugal casting (SCC) technique. The MXene-coated PET films significantly integrate transparency, UV-adsorption, infrared (IR) stealth, and electromagnetic shielding from gigahertz (GHz) to terahertz (THz) frequencies together to address the diverse demands of multifunctional applications. The all-in-one integrated flexible films exhibit excellent optoelectronic properties (sheet resistance of 163 Ω sq −1 at 82% transparency with a figure of merit of 10.88), outstanding IR stealth (IR emissivity below 55%), and ultra-broad electromagnetic shielding performance (shielding effectiveness of over 10 dB across GHz to THz frequencies). This remarkable performance is attributed to the intrinsic multifunctionality of MXene, ultra-thin thickness, horizontal alignment of nanosheets, and strong interfacial interactions achieved during the SCC process. These all-in-one flexible MXene films exhibit great potential for applications in aircraft windows, wearable electronics, and next-generation communication technology.}, archive = {J_ADVS}, author = {Tian-Yu Zhang and Qiang-Qiang Zhao and Bo Sun and Ibrar Ahmed and Ruijia Liu and Chi Liu and Han Wang and Songfeng Pei and Chang Liu and You Zeng}, doi = {10.1002/advs.202501540}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501540}, shortjournal = {Adv. Sci.}, title = {All-in-one flexible MXene/PET films via scalable scanning centrifugal casting for high transparency and ultra-wide multispectral electromagnetic responses}, volume = {12}, year = {2025}, }
• (2025). Flexible regulation of optical properties based on structure size-driven intermolecular interactions for phototherapy. ADVS, 12(27), 2501468. (www)

  @article{ , abstract = {The precise control of optical properties in molecular systems remains a challenge for phototherapy. Herein, the strategic combination of aggregation-caused quenching (ACQ) and aggregation-induced emission (AIE) molecule creates ACQ@AIE bimolecular systems with tunable optical properties, which are almost unattainable by single-component materials. Through systematic investigation of three ACQ@AIE bimolecular systems, it is established that molecule structure size differentials dictate their intermolecular interactions and consequent optical behaviors. Crucially, AIE molecule with a smaller structure size promotes ACQ molecule clustering to enhance the photothermal effect, while when the size becomes larger, particularly approaching that of ACQ molecule, facilitating π–π stacking and boosting the photodynamic effect. These distinct assembly modes revealed through combined experimental and theoretical analyses, enable precise regulation of photothermal versus photodynamic effects by simply regulating the structure size and ratio of ACQ and AIE molecules. Building on these mechanistic insights, the optimal molecule combination of ACQ@AIE bimolecular system is engineered into nanoparticles that exhibit mild photothermal effect, strong photodynamic effect, and excellent tumor accumulation and retention, achieving near-complete tumor eradication with minimal treatment cycles while maintaining good biosafety. This work not only elucidates the fundamental structure size-interaction-property relationships in ACQ@AIE bimolecular systems but also provides generalizable strategies for developing intelligent photo theranostic materials through controlled intermolecular interaction.}, archive = {J_ADVS}, author = {Zhichao Gong and Guangbo Kang and Yu Cao and Jiachen Pan and Xuejiao Rong and Xiaobing Du and Danping Zhang and He Huang and Shuxian Meng}, doi = {10.1002/advs.202501468}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501468}, shortjournal = {Adv. Sci.}, title = {Flexible regulation of optical properties based on structure size-driven intermolecular interactions for phototherapy}, volume = {12}, year = {2025}, }
• (2025). Transient interdomain interactions modulate the monomeric structural ensemble and self-assembly of huntingtin exon 1. ADVS, 12(27), 2501462. (www)

  @article{ , abstract = {Polyglutamine (polyQ) tract length expansion (≥ 36 residues) within the N-terminal exon-1 of Huntingtin (Httex1) leads to Huntington's disease, a neurodegenerative condition marked by the presence of intranuclear Htt inclusions. Notably, the polyQ tract in Httex1 is flanked by an N-terminal coiled-coil domain –N17 (17 amino acids), which promotes the formation of soluble oligomers and brings the aggregation-prone polyQ tracts in close proximity. However, the molecular mechanisms underlying the conversion of soluble oligomers into insoluble β-rich aggregates with increasing polyQ length, remain unclear. In this study, extensive atomistic molecular dynamics (MD) simulations (aggregate time ≈0.7 milliseconds) are performed to uncover the interplay between structural transformation and domain “cross-talk” on the conformational ensemble and oligomerization of Httex1 due to polyQ expansion. Notably, MD-derived ensembles of N17-Q n -P 5 monomers validated against NMR indicated that in addition to elevated α-helicity, polyQ expansion also favored transient, interdomain (N17/polyQ) interactions which resulted in the emergence of β-sheet conformations. Further, interdomain interactions modulated the stability of N17-mediated polyQ dimers and promoted a heterogeneous dimerization landscape. Finally, it is observed that the intact C-terminal proline-rich domain (PRD) promoted condensation of Httex1 through self-interactions involving its P 10 /P 11 tracts while also interacting with N17 to suppress its α-helicity.}, archive = {J_ADVS}, author = {Priyesh Mohanty and Tien Minh Phan and Jeetain Mittal}, doi = {10.1002/advs.202501462}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2501462}, shortjournal = {Adv. Sci.}, title = {Transient interdomain interactions modulate the monomeric structural ensemble and self-assembly of huntingtin exon 1}, volume = {12}, year = {2025}, }
• (2025). PRMT5 inhibitor synergizes with chemotherapy to induce resembling mismatch repair deficiency and enhance anti-TIGIT therapy in microsatellite-stable colorectal cancer. ADVS, 12(27), 2500271. (www)

  @article{ , abstract = {Microsatellite stable (MSS) colorectal cancer (CRC) is considered an “immune-cold” tumor, accounting for ≈85% of all CRC cases. The overall response rate to chemotherapy combined with immune checkpoint inhibitors in MSS CRC is typically less than 10%. The specific mechanism that enhances chemotherapy sensitivity and mediated immunogenicity renders MSS CRC more responsive to immunotherapy remains elusive. Experiments in this study identify a DNA damage repair-related epigenetic gene, protein arginine methyltransferase 5 (PRMT5), whose inhibition enhances Irinotecan (CPT-11) sensitivity and synergistically induces a postmeiotic segregation increased 2 (PMS2)-deficient-like state, leading to the release of cytosolic double-stranded DNA. This activates the cyclic GMP-AMP synthase (cGAS)-stimulator of the IFN gene (STING) signaling pathway, thereby enhancing anti-tumor immunotherapy through dendritic cell-T cell-dependent functions. Importantly, combining the epigenetic anti-tumor drug GSK3326595 with CPT-11 significantly upregulates the immune receptor tyrosine-based inhibitory motif (TIGIT) level on CD8+ T cells and subsequently demonstrates impressive anti-tumor efficacy in vivo when additional anti-TIGIT is included. Collectively, this study reveals the crucial role of PRMT5 blockade combined with CPT-11 in inducing a mismatch repair deficiency-like state and provides a novel triple-drug combination therapy strategy as a potential treatment for patients with MSS CRC.}, archive = {J_ADVS}, author = {Jiang Zhu and Shenao Fu and Xi Zou and Hanjiang Zeng and Guangzu Cui and Yinghui Peng and Diya Tang and Fan Zhang and Hong Shen and Shan Zeng and Ying Han}, doi = {10.1002/advs.202500271}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2500271}, shortjournal = {Adv. Sci.}, title = {PRMT5 inhibitor synergizes with chemotherapy to induce resembling mismatch repair deficiency and enhance anti-TIGIT therapy in microsatellite-stable colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). A phase-separated SR protein reprograms host pre-mRNA splicing to enhance disease susceptibility. ADVS, 12(27), 2500072. (www)

  @article{ , abstract = {Alternative splicing (AS) plays a vital role in the plant–microbe interaction. Modulating host precursor-mRNA AS is a key strategy employed by multiple pathogens to subvert plant immunity. However, the underlying mechanism by which the host splicing factor regulates plant immunity remains poorly understood. Here, a plant-conserved serine/arginine-rich (SR) RNA splicing factor, SR30, which negatively regulates tomato immunity against the infamous Phytophthora infestans ( P. infestans ) is identified. SR30 governs tomato mRNA AS at a genome-wide level and suppresses defense-related genes AS. During P. infestans infection, SR30 is induced to form nuclear condensates via liquid–liquid phase separation driven by intrinsically disordered regions. Importantly, the phase separation property is required for the function of SR30 in disease susceptibility and the regulation of genes AS. Knockout of SR30 via CRISPR/Cas9 improves tomato disease resistance to P. infestans , P. capsici , and P. parasitica by promoting defense genes AS. These findings uncover a novel mechanism in a phase-separated protein that regulates plant immunity by altering the AS of defense-related genes and provides a new paradigm for engineering protein condensate in crop-resistant breeding.}, archive = {J_ADVS}, author = {Dong Yan and Jie Huang and Fengqi Tian and Haidong Shu and Han Chen and Qian Peng and Hongwei Wu and Jianlong Zhao and Anireddy S. N. Reddy and Gang Li and Yuanchao Wang and Suomeng Dong}, doi = {10.1002/advs.202500072}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2500072}, shortjournal = {Adv. Sci.}, title = {A phase-separated SR protein reprograms host pre-mRNA splicing to enhance disease susceptibility}, volume = {12}, year = {2025}, }
• (2025). Dual-locking the SARS-CoV-2 spike trimer: An amphipathic molecular “Bolt” stabilizes conserved druggable interfaces for coronavirus inhibition. ADVS, 12(27), 2417534. (www)

  @article{ , abstract = {The SARS-CoV-2 spike (S) protein, a trimeric structure comprising three receptor binding domains (RBDs) and three N-terminal domains (NTDs), undergoes substantial conformational changes to a fusion-prone open state for angiotensin-converting enzyme 2 (ACE2) binding and host cell infection. Stabilizing its closed state is a key antiviral strategy but remains challenging. Here, we introduce S416, a novel amphipathic molecule acting as a “molecular bolt”. Cryo-EM study reveals that S416 binds concurrently to six sites across two distinct druggable interfaces: three molecules at the RBD-RBD interfaces and three at the NTD-RBD interfaces. This unique “dual-locking” mechanism, driven by S416's polar carboxyl head and nonpolar phenylthiazole tail, robustly stabilizes the spike trimer in a locked, closed conformation through strong inter-domain interactions, reducing structural flexibility and atomic fluctuations compared to the apo structure resolved synchronously. Crucially, these RBD-RBD and NTD-RBD interfaces are conserved across human-infecting coronaviruses, suggesting potential as broad-spectrum antiviral targets. Our findings demonstrate that the highly dynamic spike trimer can be effectively stabilized by an amphipathic molecular bolt targeting both the inter- and intra-monomer interfaces, offering a promising strategy against emerging coronaviruses.}, archive = {J_ADVS}, author = {Shiliang Li and Fang Ye and Yucheng Zheng and Jie Wang and Haoran Peng and Lili Zhu and Lili Chen and Tao Yu and Huan Ge and Jiaqi He and Binghao Zhang and Jiayun Wu and Zhiyi Zhang and Liangliang Jiang and Geng Chen and Ping Zhao and Ke Lan and Zhenjiang Zhao and Xuhong Qian and Ke Xu and Yang Du and Honglin Li}, doi = {10.1002/advs.202417534}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2417534}, shortjournal = {Adv. Sci.}, title = {Dual-locking the SARS-CoV-2 spike trimer: An amphipathic molecular “Bolt” stabilizes conserved druggable interfaces for coronavirus inhibition}, volume = {12}, year = {2025}, }
• (2025). Inherited nitrogen distribution control in covalent organic framework cathodes for efficient electrochemical lithium recovery via capacitive deionization. ADVS, 12(27), 2417140. (www)

  @article{ , abstract = {The economic recovery of lithium from brine generated by desalination plants presents a promising pathway toward achieving a sustainable water desalination economy. Selectively recovering Li + ions from brine is challenging due to the presence of other dominant ions. While electrochemical separation techniques, such as hybrid capacitive deionization (HCDI), offer several advantages, success largely depends on developing suitable cathodes currently limited to inorganic materials with notable constraints. Herein, the potential of controlling heteroatom distribution within 2D covalent organic frameworks (2D-COFs) is explored for electrochemical lithium recovery. This marks the first exploration of COF cathodes for lithium extraction via HCDI. By carefully modulating the density of heteroatoms within the framework backbone, this study aims to understand their critical role better and achieve efficient cathode materials. Notably, Tta-Dfp, the representative COF, demonstrates a lithium recovery rate of 15.7 mg g⁻¹ at 1.4 V, with a Li-ion concentration of 300 mg L⁻¹, and exhibits ∼80% selectivity for lithium extraction. At the same time, the device achieves 97.7% capacitance retention after 500 charge-discharge cycles. Through controlled COFs, density functional theory (DFT) analysis, and post-electrode characterizations, we elucidate the pivotal role of nitrogen distribution in lithium recovery.}, archive = {J_ADVS}, author = {Rajesh Dhanushkotti and Abdul Khayum Mohammed and Kayaramkodath Chandran Ranjeesh and Hema Mylnahalli Krishnegowda and Najat Maher Aldaqqa and Dinesh Shetty}, doi = {10.1002/advs.202417140}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2417140}, shortjournal = {Adv. Sci.}, title = {Inherited nitrogen distribution control in covalent organic framework cathodes for efficient electrochemical lithium recovery via capacitive deionization}, volume = {12}, year = {2025}, }
• (2025). Tumor-associated glycan exploits adenosine receptor 2A signaling to facilitate immune evasion. ADVS, 12(27), 2416501. (www)

  @article{ , abstract = {Adenosine signaling is a crucial immunosuppressive pathway within the tumor microenvironment, making it a promising target for cancer therapy. In this study, it is demonstrated that Globo H ceramide (GHCer), the most prevalent tumor-associated glycosphingolipid, influences the tumor microenvironment by activating adenosine signaling, which results in dual immunosuppressive effects on T cells. It is demonstrated that GHCer interacts with the adenosine receptor 2A (A2AR), triggering cyclic AMP (cAMP) and protein kinase A (PKA) signaling. This interaction leads to a reduction in the proliferation of CD4 + T cells while simultaneously promoting the differentiation of regulatory T cells (Tregs). Furthermore, GHCer enhances the suppressive capacity of Treg cells by upregulating inhibitory molecules such as Lymphocyte-activation gene 3 (LAG3), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), Programmed cell death 1 ligand 1 (PD-L1), and it stimulates the secretion of the immunosuppressive cytokine Interleukin 35 (IL-35). Additionally, GHCer-induced Tregs express CD39 and CD73, which further enhances adenosine production and creates a positive feedback loop in the adenosinergic pathway and A2AR signaling. Mechanistically, it is found that GHCer forms a complex with TRAX (translin-associated factor-X) and the C-terminus of A2AR, which facilitates the activation of A2AR and promotes an immunosuppressive tumor microenvironment.}, archive = {J_ADVS}, author = {Jing-Yan Cheng and Hsiu-Hui Tsai and Jung-Tung Hung and Tsai-Hsien Hung and Chun-Cheng Lin and Chien-Wei Lee and Zi-Chi Lo and Jing-Rong Huang and Shih-Pin Chiou and Yenlin Huang and Shih-Hsiang Chen and Chun-Nan Yeh and John Yu and Alice L. Yu}, doi = {10.1002/advs.202416501}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2416501}, shortjournal = {Adv. Sci.}, title = {Tumor-associated glycan exploits adenosine receptor 2A signaling to facilitate immune evasion}, volume = {12}, year = {2025}, }
• (2025). Trustworthy inverse molecular design via alignment with molecular dynamics. ADVS, 12(27), 2416356. (www)

  @article{ , abstract = {Data-driven inverse molecular design (IMD) has attracted significant attention in recent years. Despite the remarkable progress, existing IMD methods lag behind in terms of trustworthiness , as indicated by their misalignment to the ground-truth function that models the molecular dynamics. Here, TrustMol, an IMD method built to be trustworthy is proposed by inverting a reliable molecular property predictor. TrustMol first constructs a latent space with a novel variational autoencoder (VAE) and trains an ensemble of property predictors to learn the mapping from the latent space to the property space. The training samples for the ensemble are obtained from a new reacquisition method to ensure that the samples are representative of the latent space. To generate a desired molecule, TrustMol optimizes a latent design by minimizing both the predictive error and the uncertainty quantified by the ensemble. As a result, TrustMol achieves state-of-the-art performance in terms of IMD accuracy, and more importantly, it is aligned with the ground-truth function that indicates trustworthiness.}, archive = {J_ADVS}, author = {Kevin Tirta Wijaya and Navid Ansari and Hans-Peter Seidel and Vahid Babaei}, doi = {10.1002/advs.202416356}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2416356}, shortjournal = {Adv. Sci.}, title = {Trustworthy inverse molecular design via alignment with molecular dynamics}, volume = {12}, year = {2025}, }
• (2025). Forage crop research in the modern age. ADVS, 12(27), 2415631. (www)

  @article{ , abstract = {Forage crops not only provide food for livestock to meet the growing demands of the global population but are also essential for sustainable agricultural systems by rehabilitating infertile and marginal lands. A wide diversity of plant species is cultivated as forage crops, many of which possess complex genetic backgrounds, making them more challenging to improve compared to model plants and staple crops. Recent advancements in molecular biology, sequencing technologies, and genomic analysis tools have opened new avenues for the improvement of forage crops. This review provides a comprehensive examination of modern forage breeding, covering the primary types of forage, their characteristics, key functional genes utilized for enhancing forage traits, advanced breeding technologies, and the challenges and future directions in this field. By integrating the latest research and technological developments, this review aims to contribute to the advancement of forage breeding strategies that can meet the increasing global demand for sustainable and high-quality forage resources.}, archive = {J_ADVS}, author = {Qikun Liu and Gai Huang and Zhiqiang Zhang and Zhelong Lin and Xian Deng and Xueming Dong and Zhipeng Liu and Zan Wang and Yingjun Zhang and Hai-chun Jing and Kang Chong and Xiaofeng Cao}, doi = {10.1002/advs.202415631}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2415631}, shortjournal = {Adv. Sci.}, title = {Forage crop research in the modern age}, volume = {12}, year = {2025}, }
• (2025). Superior electromechanical power at rare-earth manipulated glassy morphotropic phase transitions. ADVS, 12(27), 2415533. (www)

  @article{ , abstract = {High-precision displacement control and the driving joints of artificial intelligence robotics, as well as advanced medical facilities, necessitate the use of superior lead-free electromechanical materials that exhibit substantial electrostrain and driving force while maintaining thermal stability. In this study, an effective physical approach is developed to achieve significant enhancements of 135% and 50% in symmetric electrostrain and elastic modulus, respectively, of Sm-doped (Bi,Na)TiO 3 -BaTiO 3 ceramics within the temperature range of 293–353K. This advancement facilitates a marked improvement in stress output. Unlike the prevalent focus on enhancing symmetric/asymmetric electrostrain output through polar coexistence states and defect dipoles, our approach induces superior electrostrain and stress power by inhibiting the formation of the R3c phase and manipulating the transition pathway in the morphotropic phase boundary composition of (Bi,Na)TiO 3 -based ceramics via rare-earth Sm doping. The achieved reversible glassy P4bm→P4mm and residual R3c→P4mm parallel transition paths, characterized by significant lattice expansion, enable the realization of potential electromechanical power across a broad temperature range. This approach overcomes the limitations of significant elastic softening and the deterioration of electrical properties with temperature variations at specific morphotropic/polymorphic phase transitions. Thus, it offers an effective method for generating superior electromechanical power in lead-free ferroelectrics.}, archive = {J_ADVS}, author = {Le Zhang and Liqiang He and Shuyuan Xu and Haoyu Wang and Yunlong Sun and Yating Ran and Dong Wang and Kaiyun Chen and Junkai Deng and Zibin Chen and Danyang Wang and Michael A. Carpenter and Sen Yang}, doi = {10.1002/advs.202415533}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2415533}, shortjournal = {Adv. Sci.}, title = {Superior electromechanical power at rare-earth manipulated glassy morphotropic phase transitions}, volume = {12}, year = {2025}, }
• (2025). Holistic optimization toward ultrathin flexible perovskite solar cells with high efficiency and mechanical robustness. ADVS, 12(27), 2415372. (www)

  @article{ , abstract = {An ultrathin and flexible perovskite solar cell (f-PSC) is highly desirable as a portable power source, while the rigidity of key components including perovskite and transparent electrode of a device leads to challenges in fabrication. Here, several approaches are developed to improve the mechanical flexibility and photovoltaic performance of ultrathin f-PSCs. First, a two-dimensional perovskite with low Young's modulus is introduced at the boundaries of perovskite films as a lubricant to release stress which is confirmed by in situ TEM characterization. Second, conductive PEDOT:PSS doped with sucralose is used as a transparent electrode to enhance the mechanical flexibility and photovoltaic performance of the device. Third, an ultrathin PET substrate is employed to shift the neutral plane into the perovskite film which further improves the mechanical flexibility of devices. Consequently, an ultrathin f-PSC is successfully fabricated with a power conversion efficiency of 21.44% and a record power-per-weight value of 47.8 W g −1 . A stretchable device is realized by laminating the ultrathin f-PSC on a pre-strained substrate, which shows stable performance when it is stretched up to 40%. The f-PSC shows a high efficiency of 36.25% under room light intensity, suggesting great potential for indoor photovoltaic application.}, archive = {J_ADVS}, author = {Guanqi Tang and Fangyuan Zheng and Jiajun Song and Qidong Tai and Jiong Zhao and Feng Yan}, doi = {10.1002/advs.202415372}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2415372}, shortjournal = {Adv. Sci.}, title = {Holistic optimization toward ultrathin flexible perovskite solar cells with high efficiency and mechanical robustness}, volume = {12}, year = {2025}, }
• (2025). Localized sound-integrated display speaker using crosstalk-free piezoelectric vibration array. ADVS, 12(27), 2414691. (www)

  @article{ , abstract = {Beyond visual quality, features like sound and tactile feedback have become essential to enhancing user experience, resulting in more immersive, realistic displays. Multisensory displays engaging multiple senses are increasingly in demand. Panel-integrated piezoelectric speakers represent a major advancement in audio-visual technology, merging sound generation with display panels to enable compact, versatile designs in thin, flexible formats. However, challenges like sound crosstalk between exciters and non-uniform frequency responses often compromise audio quality. To address these issues, frame-based sound vibration isolation strategies are explored to localize surface vibrations and reduce interference across multiple exciters. Through experimental measurements and Finite Element Method (FEM) simulations, it is found that increasing frame height and width, along with using materials with different acoustic impedance for the diaphragm, significantly improved frequency response uniformity and reduced Total Harmonic Distortion (THD). These enhancements simplify speaker response compensation, ensuring reliable, high-quality sound output. As demonstrated on a practical 13-inch OLED display, these results confirm that vibration-isolated, localized sound in multi-array exciters overcomes prior limitations, advancing the acoustic performance of piezoelectric panel speakers. This study provides valuable insights for future developments in thin, flexible, display-integrated audio systems, offering new possibilities in immersive, multisensory user experiences.}, archive = {J_ADVS}, author = {Inpyo Hong and Su Seok Choi}, doi = {10.1002/advs.202414691}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2414691}, shortjournal = {Adv. Sci.}, title = {Localized sound-integrated display speaker using crosstalk-free piezoelectric vibration array}, volume = {12}, year = {2025}, }
• (2025). Inhibition of RACK1-mediated NLRP3 oligomerization (Active conformation) ameliorates acute respiratory distress syndrome. ADVS, 12(27), 2411355. (www)

  @article{ , abstract = {Aberrant activation of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome contributes to the pathogenesis of fatal and perplexing pulmonary diseases. Although pharmacological inhibition of the NLRP3 inflammasome brings potent therapeutic effects in clinical trials and preclinical models, the molecular chaperones and transition governing its transformation from an auto-suppressed state to an active oligomer remain controversial. Here, this work shows that sesquiterpene bigelovin inhibited NLRP3 inflammasome activation and downstream pro-inflammatory cytokines release via canonical, noncanonical, and alternative pathways at nanomolar ranges. Chemoproteomic target identification discloses that bigelovin covalently bound to Cys168 of RACK1, disrupting the interaction between RACK1 and NLRP3 monomer and thereby suppressing NLRP3 inflammasome oligomerization in vitro and in vivo. Bigelovin treatment significantly alleviates the severity of NLRP3-related pulmonary disorders in murine models, such as LPS-induced ARDS and silicosis. These results consolidated the intricate role of RACK1 in transiting the NLRP3 state and provided a new anti-inflammatory lead and therapy for NLRP3-driven diseases.}, archive = {J_ADVS}, author = {Jian Cui and Meng Yang and Chengli Yu and Haidong Zhang and Yuan Gong and Yang Hu and Yue Wang and Qingxin Yuan and An Pan and Jiepin Li and Yaowen Hu and Zecheng Jin and Xuemei Peng and Anyuan Wu and Junwei Wang and Qian Wang and Yinan Zhang and Lihong Hu}, doi = {10.1002/advs.202411355}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2411355}, shortjournal = {Adv. Sci.}, title = {Inhibition of RACK1-mediated NLRP3 oligomerization (Active conformation) ameliorates acute respiratory distress syndrome}, volume = {12}, year = {2025}, }
• (2025). A CMTM6 nanobody overcomes EGFR-TKI resistance in non-small cell lung cancer. ADVS, 12(27), 2410945. (www)

  @article{ , abstract = {Aberrant EGFR signaling drives non-small cell lung cancer (NSCLC) development, and despite the success of tyrosine kinase inhibitor (TKI) therapies in treating NSCLC, TKI resistance remains a major obstacle. Here, we report that the chemokine-like transmembrane protein CMTM6 is physically associated with EGFR. CMTM6 is shown to be co-localized with EGFR in recycling endosomes that are marked by RAB11, thereby preventing EGFR from lysosome-mediated degradation in NSCLC cells. The level of CMTM6 is elevated in NSCLC, and high expression of CMTM6 is associated with enhanced colocalization of CMTM6 with EGFR and RAB11 in NSCLC tumors and correlated with a poor prognosis in NSCLC patients. A CMTM6-targeting nanobody is developed and administration of this agent leads to blocking of the CMTM6-EGFR interaction, reduction of the EGFR protein level, and inhibition of the proliferation of TKI-resistant NSCLC cells in vitro and suppression of the growth of EGFR-TKI-resistant NSCLC in both cell line-derived xenografts and patient-derived xenograft models. The study indicates that CMTM6 is a stabilizer of EGFR in endocytic trafficking and provides evidence to support targeting CMTM6 as a potential therapeutic strategy to overcome TKI resistance in NSCLC treatment.}, archive = {J_ADVS}, author = {Lu Xia and Jichuan Wang and Hui Xue and Haimeng Li and Qinghua Li and Sen Qin and Chunyu Yu and Yanhua Liu and Yu Gao and Lingyun Li and Sudun Guan and Enrun Zheng and Feiya Suo and Lin He and Yongsheng Wang and Wenling Han and Yongfeng Shang and Yong Geng and Luyang Sun}, doi = {10.1002/advs.202410945}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2410945}, shortjournal = {Adv. Sci.}, title = {A CMTM6 nanobody overcomes EGFR-TKI resistance in non-small cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). State of the art of low-frequency acoustic modulation: Intensity enhancement and directional control. ADVS, 12(27), 2410695. (www)

  @article{ , abstract = {High-intensity low-frequency acoustic sources with directivity play a significant role in various fields such as medical treatment, underwater communication, and environmental monitoring. However, the long wavelengths, strong penetration, and their tendency to easily diffract of low-frequency acoustic waves make it challenging to achieve directional control and intensity enhancement. Thanks to the development of acoustic metamaterials, acoustic devices can now effectively manipulate low-frequency acoustic waves at subwavelength scales with excellent acoustic performance. Currently, the directional control and intensity enhancement of low-frequency acoustic waves mainly concentrate on source design and the modulation of propagation processes. These techniques employ acoustic resonance, focusing, and other phase control methods to achieve energy concentration and directional control of low-frequency acoustic waves. Nevertheless, existing low-frequency acoustic wave control techniques still face issues such as low energy efficiency, poor directional control, and limited controllable bandwidth. This paper systematically reviews methods for achieving high-intensity emission and directional control of low-frequency acoustic waves, comprehensively compares the advantages and disadvantages of various technologies, and discusses how to extend these methods to lower acoustic frequency bands, aiming to provide new insights for the development of miniaturized, efficient, and accurately directional ultra-low frequency acoustic devices.}, archive = {J_ADVS}, author = {Jingsong Xu and Yunfeng Ye and Tao Dong and Zhaochu Yang and Nuno Miguel Matos Pires and Yu Zhou and Fuyu Tao and Jin Wang and Junshan Zhang and Guoxi Luo and Libo Zhao and Qi Mao and Yangtao Wang and Zhuangde Jiang}, doi = {10.1002/advs.202410695}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2410695}, shortjournal = {Adv. Sci.}, title = {State of the art of low-frequency acoustic modulation: Intensity enhancement and directional control}, volume = {12}, year = {2025}, }
• (2025). Self-maintainable electronic materials with skin-like characteristics enabled by graphene-PEDOT:PSS fillers. ADVS, 12(27), 2410539. (www)

  @article{ , abstract = {Conventional devices lack the adaptability and responsiveness inherent in the design of nature. Therefore, they cannot autonomously maintain themselves in natural environments. This limitation is primarily because of using rigid and fragile material components for their construction, which hinders their ability to adapt and evolve in changing environments. Moreover, they often cannot self-repair after injuries or significant damage. Even devices with self-healing, soft, and responsive properties often fail to seamlessly integrate all these attributes into a single, scalable, and cohesive platform. In this study, a significant breakthrough is introduced by utilizing graphene-poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (graphene-PEDOT:PSS) fillers to transform a typically weak, insulating, and jelly-like material into a soft electronic material with properties akin to those of living organisms, such as skin tissue. The developed electronic materials exhibit a range of other capabilities attributed to the hierarchical organization originating from filler enhancement, which includes methods such as heat regulation, 3D printability, and multiplex sensing. The introduction of this new class of materials can facilitate the self-maintenance of life-like soft robots and bioelectronics that can be seamlessly integrated within dynamic environments, such as the human body, while demonstrating the ability to sense, respond, and adapt to challenging environments.}, archive = {J_ADVS}, author = {Morteza Alehosseini and Firoz Babu Kadumudi and Sinziana Revesz and Parham Karimi Reikandeh and Jonas Rosager Henriksen and Tiberiu-Gabriel Zsurzsan and Jon Spangenberg and Alireza Dolatshahi-Pirouz}, doi = {10.1002/advs.202410539}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2410539}, shortjournal = {Adv. Sci.}, title = {Self-maintainable electronic materials with skin-like characteristics enabled by graphene-PEDOT:PSS fillers}, volume = {12}, year = {2025}, }
• (2025). Muscle-derived small extracellular vesicles mediate exercise-induced cognitive protection in chronic cerebral hypoperfusion. ADVS, 12(27), 2410209. (www)

  @article{ , abstract = {Physical exercise protects against cognitive impairment caused by chronic cerebral hypoperfusion (CCH). However, the mechanisms through which exercise sends signals from the periphery to the central nervous system remain incompletely understood. This study demonstrated that exercise promotes the secretion of muscle-derived small extracellular vesicles (sEVs), which facilitate interorgan communication between the muscle and the brain. Systematic delivery of muscle-derived sEVs enhances synaptic plasticity and alleviated cognitive impairment in CCH. Notably, miRNA sequencing reveal miR-17/20a-5p as key cargos in sEVs involved in the exercise-induced muscle-brain crosstalk. Muscle-derived sEVs are also identified as the primary source of swimming-induced miR-17/20a-5p in circulating sEVs. Mechanistically, miR-17/20a-5p binds to the DEP-domain containing mTOR-interacting protein (DEPTOR) and activates the mammalian target of rapamycin (mTOR) pathway in the hippocampus. Depletion of miR-17/20a-5p from muscle-derived sEVs impairs the exercise-induced enhancement of synaptic plasticity and cognitive function. Moreover, overexpression of DEPTOR in the hippocampus attenuates the cognitive benefits of exercise. Conversely, hippocampus-specific activation of mTOR reverses these effects, highlighting the crucial role of mTOR in mediating the positive effects of exercise. Collectively, these findings identify miR-17/20a-5p in muscle-derived sEVs as the exercise-induced myokine with potent effects on the brain, emphasizing the therapeutic potential of exercise in managing cognitive impairment.}, archive = {J_ADVS}, author = {Huawei Lin and Lianhua Yin and Weilin Liu and Rui Li and Tao Jiang and Minguang Yang and Yajun Cao and Sinuo Wang and Yan Yu and Cong Chen and Xiaoqin Guo and Wenju Wang and Huanhuan Liu and Yaling Dai and Jiamin Yan and Yanting Lin and Yanyi Ding and Chendong Ruan and Lei Yang and Tiecheng Wu and Jing Tao and Lidian Chen}, doi = {10.1002/advs.202410209}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2410209}, shortjournal = {Adv. Sci.}, title = {Muscle-derived small extracellular vesicles mediate exercise-induced cognitive protection in chronic cerebral hypoperfusion}, volume = {12}, year = {2025}, }
• (2025). Microbiome single cell atlases generated with a commercial instrument. ADVS, 12(27), 2409338. (www)

  @article{ , abstract = {Single-cell sequencing is useful for resolving complex systems into their composite cell types and computationally mining them for unique features that are masked in pooled sequencing. However, while commercial instruments have made single-cell analysis widespread for mammalian cells, analogous tools for microbes are limited. Here, EASi-seq (Easily Accessible Single microbe sequencing) is presented. By adapting the single-cell workflow of the commercial Mission Bio Tapestri instrument, this method allows for efficient sequencing of individual microbial genomes. EASi-seq allows tens of thousands of microbes to be sequenced per run and, as it is shown, can generate detailed atlases of human and environmental microbiomes. The ability to capture large genome datasets from thousands of single microbes provides new opportunities in discovering and analyzing species subpopulations. To facilitate this, a companion bioinformatic pipeline is developed that clusters genome by sequence similarity, improving whole genome assembly, strain identification, taxonomic classification, and gene annotation. In addition, the integration of metagenomic contigs with the EASi-seq datasets is demonstrated to reduce capture bias and increase coverage. EASi-seq enables high-quality single-cell genomic sequencing for microbiome samples using a simple workflow run on a commercially available platform.}, archive = {J_ADVS}, author = {Xiangpeng Li and Linfeng Xu and Benjamin Demaree and Cecilia Noecker and Jordan E. Bisanz and Daniel W. Weisgerber and Cyrus Modavi and Peter J. Turnbaugh and Adam R. Abate}, doi = {10.1002/advs.202409338}, journal = {Advanced Science}, month = {7}, number = {27}, pages = {2409338}, shortjournal = {Adv. Sci.}, title = {Microbiome single cell atlases generated with a commercial instrument}, volume = {12}, year = {2025}, }
• (2025). Novel bivalent mRNA-LNP vaccine for highly effective protection against pneumonic plague (Adv. sci. 26/2025). ADVS, 12(26), 2570206. (www)

  @article{ , archive = {J_ADVS}, author = {Uri Elia and Yinon Levy and Hila Cohen and Ayelet Zauberman and David Gur and Inbal Hazan-Halevy and Moshe Aftalion and Shani Benarroch and Erez Bar-Haim and Orit Redy-Keisar and Ofer Cohen and Dan Peer and Emanuelle Mamroud}, doi = {10.1002/advs.202570206}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2570206}, shortjournal = {Adv. Sci.}, title = {Novel bivalent mRNA-LNP vaccine for highly effective protection against pneumonic plague (Adv. sci. 26/2025)}, volume = {12}, year = {2025}, }
• (2025). Noninvasive assessment of β-secretase activity through click chemistry-mediated enrichment of neuronal extracellular vesicles to detect alzheimer's disease (Adv. sci. 26/2025). ADVS, 12(26), 2570205. (www)

  @article{ , archive = {J_ADVS}, author = {Hyoyong Kim and Junseok Lee and Audrey Qian and You-Ren Ji and Ryan Zhang and Qixin Hu and Christopher Kazu Williams and Han-Yu Chuang and Matthew D. Smalley and Yaya Xu and Liang Gao and Mary C. Mayo and Ting Zhang and Edwin M. Posadas and Zaldy S. Tan and Harry V. Vinters and Keith Vossel and Shino Magaki and Yazhen Zhu and Hsian-Rong Tseng}, doi = {10.1002/advs.202570205}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2570205}, shortjournal = {Adv. Sci.}, title = {Noninvasive assessment of β-secretase activity through click chemistry-mediated enrichment of neuronal extracellular vesicles to detect alzheimer's disease (Adv. sci. 26/2025)}, volume = {12}, year = {2025}, }
• (2025). Enhancing grasping function with a thermoresponsive ionogel adhesive glove for patients with rheumatic diseases (Adv. sci. 26/2025). ADVS, 12(26), 2570204. (www)

  @article{ , archive = {J_ADVS}, author = {Shiqiang Wang and Shiqing Liu and Jingfeng Zhang and Zhouyang Yu and Yifan Shao and Cong Zhao and Jiahong Ma and Xin Fu and Mengqi Yang and Lie Chen and Mingjie Liu and Li Wen}, doi = {10.1002/advs.202570204}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2570204}, shortjournal = {Adv. Sci.}, title = {Enhancing grasping function with a thermoresponsive ionogel adhesive glove for patients with rheumatic diseases (Adv. sci. 26/2025)}, volume = {12}, year = {2025}, }
• (2025). Ultra-low LOD H2O2 sensor based on synergistic nernst potential effect (Adv. sci. 26/2025). ADVS, 12(26), 2570203. (www)

  @article{ , archive = {J_ADVS}, author = {Zhaoqun Wang and Wen Gao and Xiaorong Niu and Yuhang Liu and Zichen Jin and Fan Zhang and Zhengdong Cheng and Xiaoning Jiang and Wendong Zhang and Ting Wang and Jianlong Ji and Xiaojie Chai and Shengbo Sang}, doi = {10.1002/advs.202570203}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2570203}, shortjournal = {Adv. Sci.}, title = {Ultra-low LOD H2O2 sensor based on synergistic nernst potential effect (Adv. sci. 26/2025)}, volume = {12}, year = {2025}, }
• (2025). Particle-assisted optoelectronic tweezers for manipulating single cells and microparticles (Adv. sci. 26/2025). ADVS, 12(26), 2570201. (www)

  @article{ , archive = {J_ADVS}, author = {Ao Wang and Shuzhang Liang and Caiding Ni and Yongyi Jia and Kangjie Wu and Wenyan Niu and Shunxiao Huang and Kaiyi Peng and Chutian Wang and Yingjian Guo and Zhijun Zhao and Lingze Zhang and Mingjie Liu and Lin Feng}, doi = {10.1002/advs.202570201}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2570201}, shortjournal = {Adv. Sci.}, title = {Particle-assisted optoelectronic tweezers for manipulating single cells and microparticles (Adv. sci. 26/2025)}, volume = {12}, year = {2025}, }
• (2025). Correlations in magnetic sub-domains as an unconventional phase diagram for van der waals ferromagnets (Adv. sci. 26/2025). ADVS, 12(26), 2570200. (www)

  @article{ , archive = {J_ADVS}, author = {Sergey Y. Grebenchuk and Magdalena Grzeszczyk and Zhaolong Chen and Makars Šiškins and Vladislav Borisov and Manuel Pereiro and Mikhail I. Katsnelson and Olle Eriksson and Kostya S. Novoselov and Maciej Koperski}, doi = {10.1002/advs.202570200}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2570200}, shortjournal = {Adv. Sci.}, title = {Correlations in magnetic sub-domains as an unconventional phase diagram for van der waals ferromagnets (Adv. sci. 26/2025)}, volume = {12}, year = {2025}, }
• (2025). Surface-engineered cenospheres encapsulating phase change materials for functional cementitious composites (Adv. sci. 26/2025). ADVS, 12(26), 2570199. (www)

  @article{ , archive = {J_ADVS}, author = {Sahand Rahemipoor and Carsten Kuenzel and Toms Valdemārs Eiduks and Andrei Shishkin and Mohammadreza Izadifar and Neven Ukrainczyk and Eduardus Koenders and Navid Ranjbar}, doi = {10.1002/advs.202570199}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2570199}, shortjournal = {Adv. Sci.}, title = {Surface-engineered cenospheres encapsulating phase change materials for functional cementitious composites (Adv. sci. 26/2025)}, volume = {12}, year = {2025}, }
• (2025). Single-cell analysis clarifies pathological heterogeneity in tenosynovial giant cell tumor and identifies biomarkers for predicting disease recurrence (Adv. sci. 26/2025). ADVS, 12(26), 2570198. (www)

  @article{ , archive = {J_ADVS}, author = {Yubin Xie and Chen Chen and Fei Wu and Yiman Peng and Jing Su and Yang Zhao and Hongjie Huang and Zhong Alan Li and Yin Pei and Wencui Li and Yi He and Tianchen Xue and Chenxi Cao and Sui Peng and Xin Zhang and Weidong Song}, doi = {10.1002/advs.202570198}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2570198}, shortjournal = {Adv. Sci.}, title = {Single-cell analysis clarifies pathological heterogeneity in tenosynovial giant cell tumor and identifies biomarkers for predicting disease recurrence (Adv. sci. 26/2025)}, volume = {12}, year = {2025}, }
• (2025). Tβ4-engineered ADSC extracellular vesicles rescue cell senescence through separable microneedle patches for diabetic wound healing. ADVS, 12(26), 2505009. (www)

  @article{ , abstract = {Microneedles loaded with bioactive substances have demonstrated efficacy in wound healing, while their application in the elderly chronic wounds, aggravated by cellular senescence, is still a significant challenge. Here, a novel therapeutic strategy is presented utilizing Thymosin β4 (Tβ4)-modified adipose-derived stem cell extracellular vesicles (ADSC-EVs) delivered via separable microneedle patches (MN@EVs Tβ4 ). The therapeutic EVs Tβ4 are derived from ADSCs that overexpress Tβ4, a factor that reverses cellular senescence. Leveraging the drug-loading and release properties of gelatin methacryloyl and poly(ethylene glycol) diacrylate, EVs Tβ4 are encapsulated within the tips of the microneedles. Notably, the soluble hyaluronic acid base layer dissolves rapidly and separates from the tips upon exudate absorption, enabling a sustained release of EVs Tβ4 . Subsequently, it is demonstrated its ability to mitigate senescence and improve function via the PTEN/PI3K/AKT pathway. Furthermore, MN@EVs Tβ4 patches showed significant efficacy in reversing senescence and promoting wound healing in diabetic wound models. Thus, the engineered ADSC-EVs, combined with separable microneedle patches, represent a promising bioengineering strategy for clinical wound management.}, archive = {J_ADVS}, author = {Youjun Ding and Jinglin Wang and Jiaye Li and Yi Cheng and Shuyin Zhou and Yepeng Zhang and Yuanjin Zhao and Min Zhou}, doi = {10.1002/advs.202505009}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2505009}, shortjournal = {Adv. Sci.}, title = {Tβ4-engineered ADSC extracellular vesicles rescue cell senescence through separable microneedle patches for diabetic wound healing}, volume = {12}, year = {2025}, }
• (2025). The e3 ligase NEDD4L prevents colorectal cancer liver metastasis via degradation of PRMT5 to inhibit the AKT/mTOR signaling pathway. ADVS, 12(26), 2504704. (www)

  @article{ , abstract = {Colorectal cancer is the second most common cause of cancer mortality worldwide, and liver metastasis is the major cause of death of patients with colorectal cancer. Dysfunctional E3 ligase activity has recently been shown to be associated with colorectal cancer. However, the key E3 ligases affecting colorectal cancer liver metastasis remain unknown. Therefore, an shRNA library targeting 156 E3 ubiquitin ligases has been used to perform an in vivo loss-of-function screen of a human colorectal cancer cell line in a mouse model of liver metastasis. The screen reveals that neural precursor cell expressed developmentally down-regulated gene 4-like (NEDD4L) knockdown promotes colorectal cancer liver metastasis. Mechanistic studies reveal that NEDD4L binds to the PPNAY motif in protein arginine methyltransferase 5 (PRMT5) and ubiquitinates PRMT5 to promote its degradation. PRMT5 degradation attenuates the arginine methylation of AKT1 to inhibit the AKT/mTOR signaling pathway. The effect of NEDD4L decreases colorectal cancer cell proliferation to suppress colonization. This study is the first to show that PRMT5 is a substrate of NEDD4L and reveals not only the metastasis-inhibiting function of NEDD4L but also a novel mechanism by which NEDD4L prevents colorectal cancer liver metastasis. These findings may provide a new preventive strategy for liver metastasis.}, archive = {J_ADVS}, author = {Zhewen Dong and Xiaofei She and Junxian Ma and Qian Chen and Yaqun Gao and Ruiyan Chen and Huanlong Qin and Bing Shen and Hua Gao}, doi = {10.1002/advs.202504704}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2504704}, shortjournal = {Adv. Sci.}, title = {The e3 ligase NEDD4L prevents colorectal cancer liver metastasis via degradation of PRMT5 to inhibit the AKT/mTOR signaling pathway}, volume = {12}, year = {2025}, }
• (2025). MdDSK2a-like-MdMTA module functions in apple cold response via regulating ROS detoxification and cell wall deposition. ADVS, 12(26), 2504405. (www)

  @article{ , abstract = {N 6 -methyladenosine (m 6 A) is the most abundant internal RNA modification in eukaryotic cells. Although the importance of its roles in mRNA metabolism, plant development, and stress responses has been well documented, regulation of its machinery is largely unknown in plants. Here, it is reported that MdMTA positively regulates cold tolerance. Combining MeRIP-seq and RNA-seq, it is found that MdMTA regulates the m 6 A and expression levels of cold-responsive genes under cold stress, including those involved in reactive oxygen species (ROS) detoxification and cell wall deposition. Further analysis reveals that MdMTA promotes ROS scavenging and the deposition of cellulose and hemicellulose by regulating the mRNA stability of the relevant genes under cold conditions. MdDSK2a-like, a ubiquitin receptor protein, mediates MdMTA degradation by the 26S ubiquitin-dependent proteasome and autophagy pathways. MdDSK2a-like negatively regulates cold tolerance by reducing the m 6 A levels of MdMTA target genes. Consistently, MdDSK2a-like inhibits ROS scavenging and the deposition of cellulose and hemicellulose under cold conditions. Genetic dissection shows that MdDSK2a-like acts upstream of MdMTA in cold response. The results not only reveal the degradation of MdMTA, but also illustrate the molecular mechanism of the MdDSK2a-like-MdMTA module in m 6 A modification and cold response.}, archive = {J_ADVS}, author = {Nan Hou and Jieqiang He and Chana Bao and Fang Zhi and Xiaoxia Shen and Yu Liu and Chaoshuo Li and Tianle Fan and Xinyue Yang and Baohua Chu and Gege Qin and Zeyuan Liu and Chuang Mei and Bin Tan and Jiancan Feng and Fengwang Ma and Mickael Malnoy and Xuewei Li and Qingmei Guan}, doi = {10.1002/advs.202504405}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2504405}, shortjournal = {Adv. Sci.}, title = {MdDSK2a-like-MdMTA module functions in apple cold response via regulating ROS detoxification and cell wall deposition}, volume = {12}, year = {2025}, }
• (2025). Ultra-stable and highly luminescent perovskite for multi-color ultraviolet single-pixel imaging. ADVS, 12(26), 2504307. (www)

  @article{ , abstract = {Ultraviolet (UV) detection and spectral imaging technology play a crucial role in information acquisition. However, this wavelength is beyond the silicon detectors’ response range. Currently, all-inorganic lead halide perovskite nanocrystals exhibit excellent photoluminescent properties converting UV photons to visible photons, which provide a solution for UV detection. Nevertheless, their practical application is restricted by poor stability when exposed to water, UV light, or heat. Therefore, it is essential to develop a viable preparation method for producing high-performance thin film devices. In this study, a design is proposed involving CsPbX 3 composites, doped with Mg 2+ and coated with Styrene-Ethylene-Butylene-Styrene (SEBS). Notably, the Mg-CsPbX 3 @SEBS demonstrate exceptional environmental stability, linearity in UV resistance, and water stability, exhibiting a mere 18% decrease in luminous intensity after 168 h of immersion, Additionally, these composites demonstrate high-temperature stability, enduring temperatures up to 500 K. Using compressed sensing technology and composite films, multi-color imaging is also achieved under various UV light conditions with a resolution of 128 × 128 pixels. This work provides valuable insights into the down-conversion properties of perovskite materials, broadening their potential applications.}, archive = {J_ADVS}, author = {Bin Xu and Menglu Chen and Kenan Zhang and Jianbang Mu and Jie Cao and Hongyu Lv and Haoyu Zhang and Xingting Zhou and Feng Shi and Qun Hao}, doi = {10.1002/advs.202504307}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2504307}, shortjournal = {Adv. Sci.}, title = {Ultra-stable and highly luminescent perovskite for multi-color ultraviolet single-pixel imaging}, volume = {12}, year = {2025}, }
• (2025). SNORA74A drives self-renewal of liver cancer stem cells and hepatocarcinogenesis through activation of notch3 signaling. ADVS, 12(26), 2504054. (www)

  @article{ , abstract = {Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs. SNORA74A deletion impaired the self-renewal of liver CSCs and suppressed hepatocarcinogenesis. Mechanistically, highly expressed SNORA74A in liver CSCs bound DCAF13 to prevent K48 linked ubiquitination of E2F2 for degradation. E2F2 induced NOTCH3 transcription to initiate Notch3 signaling activation, leading to self-renewal of liver CSCs and hepatocarcinogenesis. Moreover, expression levels of SNORA74A and NOTCH3 are positively related with severity and poor prognosis of hepatocellular carcinoma (HCC) patients. Of note, antisense oligonucleotides (ASOs) against SNORA74A showed effective efficacy for HCC tumors, suggesting SNORA74A might be a potential therapeutic target for HCC therapy by eliminating liver CSCs.}, archive = {J_ADVS}, author = {Ziheng Zhou and Yang Gu and Zhibin Yi and Jianyi Wang and Zhen Xiong and Hui Guo and Ying Du and Xiaoxiao Zhu and Lei He and Weizheng Ren and Yong Tian and Yanying Wang and Zusen Fan}, doi = {10.1002/advs.202504054}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2504054}, shortjournal = {Adv. Sci.}, title = {SNORA74A drives self-renewal of liver cancer stem cells and hepatocarcinogenesis through activation of notch3 signaling}, volume = {12}, year = {2025}, }
• (2025). Inhibition of heat shock protein 90β by catalpol: A potential therapeutic approach for alleviating inflammation-induced cartilage injuries in osteoarthritis. ADVS, 12(26), 2503909. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a degenerative joint disease characterized by the metabolic dysfunction of chondrocytes. A promising therapeutic strategy for OA involves suppressing the catabolism of the chondrocyte and promoting its anabolism to restore joint homeostasis. Here, it is demonstrated that Catalpol, a natural compound, can promote chondrocyte anabolic and proliferation, while inhibiting the catabolic activities and oxidative stress, thereby maintaining the dynamic balance of the extracellular matrix and alleviating inflammation-induced cartilage damage. Mechanistically, it has been discovered that Catalpol acts as a direct inhibitor of heat shock protein 90β (Hsp90β), and the amino acids ASP88, THR179, ASP49, and ASN46 of N-terminal domain-Hsp90β are confirmed as the binding sites for Catalpol. Knockdown of Hsp90β in primary chondrocytes demonstrates a similar biological effect as Catalpol treatment. Moreover, to develop a nanoparticle-based interventional platform for OA management, biodegradable mesoporous silica nanoparticles (bMSN) are prepared to load Catalpol (Ca-bMSN). The engineered Ca-bMSN is able to penetrate into the chondrocytes, prolong retention in the joint space, and mitigate OA progression. These findings shed light on a potential mechanism by which Catalpol modulates chondrocyte metabolism, offering a promising therapeutic strategy for OA treatment.}, archive = {J_ADVS}, author = {Zhenwei Zhou and Binghua Zhang and Lang Liu and Jie Yang and Yuting Wang and Cheng Lv and He Zhang and Yuchi Wei and Zhanliang Jiang and Zeyu Peng and Daqing Zhao and Xiangyang Leng and Xiangyan Li and Hang Su and Haisi Dong}, doi = {10.1002/advs.202503909}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503909}, shortjournal = {Adv. Sci.}, title = {Inhibition of heat shock protein 90β by catalpol: A potential therapeutic approach for alleviating inflammation-induced cartilage injuries in osteoarthritis}, volume = {12}, year = {2025}, }
• (2025). Light-driven PAA adhesive: A green bonding platform integrating high-performance, environmental resilience, and closed-loop recyclability. ADVS, 12(26), 2503788. (www)

  @article{ , abstract = {The increasing demand for environmentally benign materials has driven significant interest in water-based adhesives due to their low toxicity and ecological advantages. However, conventional formulations face persistent challenges including limited bonding strength, complex manufacturing processes, and compromised storage stability. To address these limitations, a polyacrylic acid-based aqueous adhesive (PAA) is developed through a novel visible-light catalytic platform. This approach ensures a mild catalytic cycle, thereby promoting sustained stability. The strategic integration of hydrogen bonding, electrostatic interactions, and mechanical interlocking enhances interfacial adhesion. Notably, the adhesive demonstrates an adhesion strength of up to 20.86 MPa on wood and 12.91 MPa on bamboo substrates. Its composition confers stability across diverse environmental conditions, including extreme temperature variations (−196 °C–200 °C), prolonged storage (> 270 days), and resistance to mechanical stress and solvent exposure. Furthermore, PAA exhibits full recyclability through a water-mediated dissociation and recovery process. This study represents a pioneering application of novel visible-light catalysis in adhesive synthesis, advancing the development of sustainable high-performance bonding systems.}, archive = {J_ADVS}, author = {Xueying Fu and Jingtian Chen and Yuqi Zhao and Yanan Liu and Chenyang Xie and Xuhang Zhang and Yingdan Liu and Jingyue Yang}, doi = {10.1002/advs.202503788}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503788}, shortjournal = {Adv. Sci.}, title = {Light-driven PAA adhesive: A green bonding platform integrating high-performance, environmental resilience, and closed-loop recyclability}, volume = {12}, year = {2025}, }
• (2025). “Confined eutectic” strategy for visual refrigeration responsive fluorescent materials with easy preparation and multi-color tunability. ADVS, 12(26), 2503779. (www)

  @article{ , abstract = {The temperature response window is a very critical parameter for evaluating temperature sensing performance of thermofluorochromic materials, and its regulation has long been a key focus in this field. Especially, the indication of refrigeration temperature is of great significance as it relates to public health and food safety. However, developing fluorochromic materials capable of visually reading out refrigeration temperature remains challenges. Herein, a “confined eutectic” strategy is proposed to develop fluorochromic materials that are easy to prepare and can naked-eye recognition of refrigeration temperature. Through supramolecular interactions between dopant and host matrix, eutectic micro-domains are formed and their crystallization point is effectively lowered into the range of 0–10 °C. The excellent crystalline host matrix provides a “confinement” effect, and thereby enhancing the crystallinity of the eutectics, which enables precise aggregation and dispersion of surrounding fluorophores, resulting in significant color changes. The mechanism is validated through variable-temperature fluorescence spectra, confocal laser scanning microscopy and phase diagram analysis. The obtained materials exhibit high fluorescence color contrast, and can apply to diverse dyes for multi-mode and multi-color readout. This work not only open up new insights for refrigeration temperature responsive fluorochromic materials, but also provides a new way for visual regulation crystallinity.}, archive = {J_ADVS}, author = {Jifang Zhao and Jiahui Du and Tianyou Qin and Sean Xiao-An Zhang and Lan Sheng}, doi = {10.1002/advs.202503779}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503779}, shortjournal = {Adv. Sci.}, title = {“Confined eutectic” strategy for visual refrigeration responsive fluorescent materials with easy preparation and multi-color tunability}, volume = {12}, year = {2025}, }
• (2025). Implantable biophotonic device for wirelessly cancer real-time monitoring and modulable treatment. ADVS, 12(26), 2503778. (www)

  @article{ , abstract = {Miniaturized bio-devices present a promising solution to address the limitations of conventional therapeutic equipment, such as bulkiness and high cost, while facilitating continuous monitoring of cancer development and treatment progression. Herein, a flexible wirelessly implantable biophotonic device is developed via integrating an oxyhemoglobin saturation (sO 2 ) sensing probe, a low-power Bluetooth microcontroller unit, and a wireless power module on a flexible printed circuit board. It is fabricated to identify tumors (˂ 30 mm 3 ) from normal tissues by monitoring sO 2 levels indicative of the tumor hypoxic microenvironment. Furthermore, this device can also evaluate the therapeutic progression of chemotherapy drugs like vadimezan, which reduces sO 2 levels by disrupting tumor angiogenesis. The µ-LED in the biophotonic device can function as a light source for in situ photodynamic therapy while simultaneously monitoring the oxygen consumption during the treatment process. The biophotonic device is lightweight, thin, and flexible, allowing seamless implantation within the body. It operates via wireless power and data transmission without disrupting normal physiological activities. Hence, the biophotonic device is capable of concurrently achieving precise tumor discrimination, modulable in situ treatments, and real-time progression monitoring, enabling the evaluation and optimization of therapeutic efficacy.}, archive = {J_ADVS}, author = {Renhao Nie and Qingyan Jia and Yuanying Li and Changhan Yan and Xiyin Liu and Yaolan Tao and Jianhong Zhang and Peng Li and Wei Huang}, doi = {10.1002/advs.202503778}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503778}, shortjournal = {Adv. Sci.}, title = {Implantable biophotonic device for wirelessly cancer real-time monitoring and modulable treatment}, volume = {12}, year = {2025}, }
• (2025). The locus coeruleus-periaqueductal gray GABAergic projection regulates comorbid pain and depression. ADVS, 12(26), 2503739. (www)

  @article{ , abstract = {The locus coeruleus (LC) noradrenergic (NA) neurons regulate pain and depression through their projections to various downstream nuclei. Although GABAergic (GABA) neurons in and near the LC (LC-GABA neurons) provide inhibitory synaptic inputs to LC-NA neurons, it remains unknown whether they are implicated in neuropathic pain and comorbid depression through LC-NA neurons. This study demonstrates that LC-GABA neurons respond to noxious stimuli with enhanced activity, and stimulation of these neurons elevates pain thresholds and exerts an anti-depressant-like effect in naive and neuropathic pain mice. Conversely, inhibition of LC-GABA neurons leads to hyperalgesia and depression-like behaviors in naive mice and exacerbates existing pain- and depression-like behaviors in neuropathic pain mice. Although LC-GABA neurons inhibit pain responses in LC-NA neurons, they modulate pain thresholds and depression-like behaviors in a manner independent of LC-NA neurons. In contrast, the projection from LC-GABA neurons to the ventrolateral periaqueductal gray (vlPAG) is enhanced, and stimulation of this projection mimics that of LC-GABA neurons conferring analgesic- and antidepressant-like effects. This study reveals the enhancement of the LC GABA -vlPAG GABA projection as a compensatory mechanism in neuropathic pain and suggests that further augmentation of this projection may be a therapeutic strategy for the treatment of comorbid neuropathic pain and depression.}, archive = {J_ADVS}, author = {Yuan Gao and Xue Zhang and Xiao-Juan Liu and Yi-Ling Sun and Cui Yin and Dong-Liang Tang and Cheng Xiao and Chunyi Zhou}, doi = {10.1002/advs.202503739}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503739}, shortjournal = {Adv. Sci.}, title = {The locus coeruleus-periaqueductal gray GABAergic projection regulates comorbid pain and depression}, volume = {12}, year = {2025}, }
• (2025). CeiTEA: Adaptive hierarchy of single cells with topological entropy. ADVS, 12(26), 2503539. (www)

  @article{ , abstract = {Advances in single-cell RNA sequencing (scRNA-seq) enable detailed analysis of cellular heterogeneity, but existing clustering methods often fail to capture the complex hierarchical structures of cell types and subtypes. CeiTEA is introduced, a novel algorithm for adaptive hierarchical clustering based on topological entropy (TE), designed to address this challenge. CeiTEA constructs a multi-nary partition tree that optimally represents relationships and diversity among cell types by minimizing TE. This method combines a bottom-up strategy for hierarchy construction with a top-down strategy for local diversification, facilitating the identification of smaller hierarchical structures within subtrees. CeiTEA is evaluated on both simulated and real-world scRNA-seq datasets, demonstrating superior clustering performance compared to state-of-the-art tools like Louvain, Leiden, K-means, and SEAT. In simulated multi-layer datasets, CeiTEA demonstrated superior performance in retrieving hierarchies with a lower average clustering information distance of 0.15, compared to 0.39 from SEAT and 0.67 from traditional hierarchical clustering methods. On real datasets, the CeiTEA hierarchy reflects the developmental potency of various cell populations, validated by gene ontology enrichment, cell-cell interaction, and pseudo-time analysis. These findings highlight CeiTEA's potential as a powerful tool for understanding complex relationships in single-cell data, with applications in tumor heterogeneity and tissue specification.}, archive = {J_ADVS}, author = {Bowen Tan and Shiying Li and Mengbo Wang and Shuai Cheng Li}, doi = {10.1002/advs.202503539}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503539}, shortjournal = {Adv. Sci.}, title = {CeiTEA: Adaptive hierarchy of single cells with topological entropy}, volume = {12}, year = {2025}, }
• (2025). Superlattice engineering on 2D Bi2Te3-Sb2Te3 chalcogenides. ADVS, 12(26), 2503492. (www)

  @article{ , abstract = {As a focal point in materials science, 2D superlattices, comprising periodically arranged nanostructures, have emerged as promising platforms for engineering, optoelectronic, and quantum phenomena. In this work, an innovative approach is studied to fabricate multi-layered 2D Bi 2 Te 3 -Sb 2 Te 3 chalcogenide superlattices including wrapped, lateral and vertical ones. Using a novel precursor switching method, wrapped 2D van der Waals superlattices are synthesized via chemical vapor deposition. Thermal annealing and focused ion beam techniques are employed to achieve both lateral and vertical superlattices with controlled dimensions and sharp interfaces. Comprehensive structural and electronic characterization revealed the high crystalline quality and electronic properties of these superlattices. A comprehensive growth model is also developed to elucidate the growth mechanism and optimize the growth parameters. This research demonstrates a feasible approach to fabricate wrapped, lateral, and vertical superlattices, laying the foundation for further advanced study of their physical properties and potential device applications.}, archive = {J_ADVS}, author = {Han Wang and Songqing Zhang and Huijia Luo and Wenwu Pan and Zekai Zhang and Junliang Liu and Yongling Ren and Cailei Yuan and Wen Lei}, doi = {10.1002/advs.202503492}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503492}, shortjournal = {Adv. Sci.}, title = {Superlattice engineering on 2D Bi2Te3-Sb2Te3 chalcogenides}, volume = {12}, year = {2025}, }
• (2025). Achromatic 3D multi-color orbital angular momentum holography. ADVS, 12(26), 2503488. (www)

  @article{ , abstract = {Orbital angular momentum (OAM) holography represents a transformative technique for enhancing the information channel capacity of holographic systems through the convolution of theoretical infinite OAM states with discrete sampling target images. However, the inherent axial chromatic aberration (ACA) in Fourier lens functions leads to the misalignment of Fourier planes for OAM-dependent holograms across different wavelengths, thereby limiting 3D multicolor OAM holography. To address this challenge, a novel approach achieving achromatic 3D multi-color OAM holography using a spatial multiplexing scheme is presented. Specifically, an optically digitalized achromatic OAM-dependent hologram is developed by superposing wavelength-specific lens functions onto monochromatic Fourier OAM-dependent holograms, followed by high-resolution spatial discretization and interleaving via two-photon lithography (TPL). Experimental results demonstrate that the method enables a double-plane (along the propagation direction of light), 3-color (633, 532, and 460 nm), and 3-channel OAM-multiplexing holographic display (OAM order l en = 1,4, and 7) with the ACA correction, utilizing a nano-printed hologram featuring a subwavelength (600 nm) pixel size. This breakthrough paves the way for high-capacity, multi-spectral 3D holographic data storage and retrieval, with significant implications for augmented reality (AR)/virtual reality (VR) display, optical holographic encryption, and optical artificial intelligence.}, archive = {J_ADVS}, author = {Hang Su and Baoli Li and Yike Bai and Yiqi Ye and Yibo Dong and Xinyuan Fang}, doi = {10.1002/advs.202503488}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503488}, shortjournal = {Adv. Sci.}, title = {Achromatic 3D multi-color orbital angular momentum holography}, volume = {12}, year = {2025}, }
• (2025). Sustainable development of high-performance poly(ester-imine) biobased thermosets. ADVS, 12(26), 2503483. (www)

  @article{ , abstract = {The massive production of materials based on petroleum derivatives and often toxic compounds generates significant environmental pollution. In this context, the development of environmentally friendly alternatives becomes crucial. This study investigates the synthesis of eco-friendly and high-performance poly(ester-imine) thermosets by sustainable approaches. Starting with vanillin or syringaldehyde, the synthesis involves the introduction of imine linkages within the epoxy monomer's structure. A new strategy is used through the cross–linking of the designed epoxy monomers using anhydrides, without initiators. This approach conducts to novel poly(ester-imine) thermosets with high performances that exceed those reported in previous studies. The thermo-mechanical investigations show that the novel-designed thermosets have performant properties with storage moduli at room temperature ranging between 0.3‒1.74 GPa and glass transition values between 90 and 170 °C. The Limit Oxygen Index (LOI) in the range of 24‒36%, confirms the excellent flame-retardant properties without the addition of supplementary additives. Their low-density values (1.05‒1.36 g cm −3 ) and the very low WA% ≈0.09–1.15 % after 24 h make them well-suited for a range of uses where weight and hydrophobicity considerations are critical. The obtained results place these poly(ester-imine) materials as promising sustainable candidates for a wide range of high-end applications.}, archive = {J_ADVS}, author = {Roxana Dinu and Sandu Cibotaru and David D. Swanson and Alice Mija}, doi = {10.1002/advs.202503483}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503483}, shortjournal = {Adv. Sci.}, title = {Sustainable development of high-performance poly(ester-imine) biobased thermosets}, volume = {12}, year = {2025}, }
• (2025). C1q+ Macrophage–Tumor cell interaction promoted tumorigenesis via GPR17/PI3K/AKT pathway induced DNA hypermethylation in nasopharyngeal carcinoma. ADVS, 12(26), 2503434. (www)

  @article{ , abstract = {Nasopharyngeal carcinoma (NPC) is one of the common head and neck cancers in Southern China and Southeast Asia. Although current studies have adequately characterized the tumor microenvironment (TME) of NPC, little attention has been paid to how cell-cell interactions within the TME promote tumorigenesis. In this study, it is found that C1q + tumor-associated macrophages (TAMs) are significantly enriched in NPC tumors. Moreover, both enriched C1q + TAMs and elevated C1q expression are associated with the progression and poor prognosis in NPC patients. In vitro and in vivo studies demonstrate that C1q directly boosts the malignancy and stemness of tumor cells. Mechanistically, C1q activates the Phosphatidylinositol-3-kinase (PI3K)/AKT pathway through interacting with GPR17, a member of the G protein-coupled receptor family, thereby inducing DNA hypermethylation of tumor cells to promote tumor development. It is further proved that DNA hypermethylated NPC cells induced by C1q elicited the immunosuppressive phenotype of TAMs. Targeted blockade of C1q with a neutralizing antibody restricts NPC progression in the humanized mouse model. It is assumed that the differentiation of C1q + TAMs possibly acquired both M1 and M2 polarization conditions. These findings provide new insights into the cellular communication in the TME of NPC and may have important applications for the development of new targeted therapies.}, archive = {J_ADVS}, author = {Yunzhi Liu and Cuicui Huang and Min Luo and Wenfu Lu and Baifeng Zhang and Lu Bai and Shuyue Zheng and Yanan Tan and Shanshan Li and Huali Wang and Lanqi Gong and Xinyuan Guan}, doi = {10.1002/advs.202503434}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503434}, shortjournal = {Adv. Sci.}, title = {C1q+ Macrophage–Tumor cell interaction promoted tumorigenesis via GPR17/PI3K/AKT pathway induced DNA hypermethylation in nasopharyngeal carcinoma}, volume = {12}, year = {2025}, }
• (2025). Two dimensional conjugated Metal–Organic frameworks with multiple redox-active sites towards high-performance sodium-ion battery. ADVS, 12(26), 2503369. (www)

  @article{ , abstract = {Two dimensional (2D) conjugated metal–organic frameworks (2D c -MOFs) have emerged as promising electroactive materials for energy storage owing to their high conductivity and large charge carrier mobility. However, their broader implementation is hindered by limitations in capacity and cycling stability, primarily due to the restricted density, diversity, and stability of the redox sites. In this study, a new 2D c -MOF (Cu-TTPQ) with multiple redox-active sites that incorporated quinone and pyrazine functionalities as cathode materials for sodium-ion batteries (SIBs) is developed. Notably, 2D layered Cu-TTPQ with a rigid skeleton is directly synthesized from a flexible precursor ligand through in situ cyclodehydrogenation and coordination assembly. Two other contrastive 2D c -MOF analogs (Cu-TBPQ and Cu-DDQP) sharing similar structural motifs with Cu-TTPQ but featuring distinct conductivities and energy band characteristics are prepared for systematic investigation. By contrast, Cu-TTPQ demonstrates a higher reversible capacity of 214.8 mAh g −1 at 0.05 A g −1 , along with high cycling stability, showing impressive cyclability with minimal capacity decay even after 1800 cycles at 5.0 A g −1 . This work elucidates the rationality of introducing multiple redox-active sites to improve the overall performance of 2D c -MOFs as cathode materials for SIBs.}, archive = {J_ADVS}, author = {Meiling Qi and Linqi Cheng and Xupeng Zhang and Yuzhao Guo and Xi Su and Xiaoxiao Sun and Yi Liu and Lei Wang and Heng-Guo Wang and Long Chen}, doi = {10.1002/advs.202503369}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503369}, shortjournal = {Adv. Sci.}, title = {Two dimensional conjugated Metal–Organic frameworks with multiple redox-active sites towards high-performance sodium-ion battery}, volume = {12}, year = {2025}, }
• (2025). Artificial intelligent-enhanced metabolite profiling for intraoperative IDH1 genotyping in glioma using an orthogonally responsive SERS probe. ADVS, 12(26), 2503360. (www)

  @article{ , abstract = {Intraoperative identification of the isocitrate dehydrogenase type 1 (IDH1) genotype, a key molecular marker in glioma, is essential for optimizing surgical strategies and tailoring post-surgical treatments. However, current clinical practices lack effective methods for real-time IDH1 genotype detection during surgery. Here, a novel strategy is proposed for intraoperative IDH1 genotype identification by simultaneously measuring two redox-related metabolites. A surface-enhanced Raman scattering (SERS) probe is developed to detect glutathione and hydrogen peroxide concentrations through orthogonally responsive Raman signals. Additionally, a deep learning algorithm is implemented, leveraging 2D Raman spectra transformation and multi-task learning to enhance measurement speed and accuracy. This AI-assisted SERS approach can identify the IDH1 genotype in glioma patients within 7 min. In a cohort of 31 glioma patients, the system achieved an area under the receiver operating characteristic curve of 0.985 for accurate IDH1 genotype differentiation. This study holds significant promise for refining surgical decision-making and personalizing post-surgical treatments by enabling rapid intra-operative molecular biomarker identification.}, archive = {J_ADVS}, author = {Hang Yin and Xin Zhang and Zheng Zhao and Chong Cao and Minhua Xu and Suhongrui Zhou and Tian Xuan and Ziyi Jin and Limei Han and Yang Fan and Cong Wang and Xiao Zhu and Ying Mao and Jinhua Yu and Cong Li}, doi = {10.1002/advs.202503360}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503360}, shortjournal = {Adv. Sci.}, title = {Artificial intelligent-enhanced metabolite profiling for intraoperative IDH1 genotyping in glioma using an orthogonally responsive SERS probe}, volume = {12}, year = {2025}, }
• (2025). Packaging metal atomic clusters for universal and robust protection through cluster beam process. ADVS, 12(26), 2503347. (www)

  @article{ , abstract = {Size-selected gas-phase aggregated metal clusters have long been considered as embryos of materials. However, a significant proportion of these clusters are susceptive to damage when exiting vacuum. Consequently, effective protection is highly desirable. Here a cluster packaging and protection strategy is presented based on controllable cluster beam implantation into polymethyl methacrylate (PMMA). In this strategy, the size selection of gas-phase clusters and the synergistic heating of PMMA during implantation are combined, thereby achieving nondestructive packaging of atomically precise cluster under soft-landing conditions. The packaged clusters exhibit robust and universal protection. Robustness is reflected in the unaltered oxidation resistance of Mo clusters after exposure to air for over 30 days, as well as the effective agglomeration resistance at temperatures up to 100 °C or in liquid. Universality is demonstrated by the successful protection of a wide range of size-selected clusters, including Mo clusters ranging from Mo 2057 to Mo 6 , and Ta 2057 , Cu 923 , W 55 , (Re–Mo) 147 clusters. This protection is attributed to both a stable, albeit weak PMMA-Mo bonding, forming Mo─O─C─C species that stabilize the clusters, and the direct implantation of gas-phase cluster into solid-phase PMMA. This helps pave the way for further investigation and applications of gas-phase metal clusters.}, archive = {J_ADVS}, author = {Siqi Lu and Zixiang Zhao and Jinsen Han and Jun Wang and Yongxin Zhang and Yu Du and Fangyu Guo and Zhichao Wang and Shenghui Wang and Sichen Tang and Kuojuei Hu and Jianguo Wan and Jiayu Dai and Fengqi Song}, doi = {10.1002/advs.202503347}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503347}, shortjournal = {Adv. Sci.}, title = {Packaging metal atomic clusters for universal and robust protection through cluster beam process}, volume = {12}, year = {2025}, }
• (2025). In situ surface polishing enables VOC approaching 95% of the theoretical limit for efficient inverted perovskite solar cells. ADVS, 12(26), 2503342. (www)

  @article{ , abstract = {Surface modification of perovskite films by conventional chemical additives suffers from the complexity of the process and the risk of secondary contamination, which limits the open-circuit voltage ( V OC ) of the perovskite solar cells (PSCs). The utilization of the clean-passivate strategy for the polishing of perovskite films has garnered considerable attention in recent years. Nevertheless, this method necessitates the incorporation of additives and does not ensure their complete removal, which may potentially compromise the stability of the devices. Here, a simple additive-free in situ surface polishing (ISSP) strategy is proposed to reconstruct the surface of perovskite films and mitigate V OC loss. The ISSP treatment, based on a green polishing agent of 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP), has demonstrated its effectiveness in reducing surface defects, optimizing energy level alignment, and improving interfacial contacts. The ISSP-treated PSCs exhibit a minimal V OC loss of 0.35 V, approaching 95% of the theoretical V OC limit. As a result, the PSCs exhibit high power conversion efficiency (PCE) and stability, with a high PCE of 24.13% and maintaining 91.1% of the initial PCE after over 2,500 h of N 2 storage (ISOS-D-1). Furthermore, the ISSP treatment is applicable to flexible PSCs (FPSCs) to obtain both high efficiency and mechanical robustness.}, archive = {J_ADVS}, author = {Han-Wen Zhang and Yan-Gang Bi and Yi-Fan Wang and Mu Lin and Chang Liu and Jing Feng}, doi = {10.1002/advs.202503342}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503342}, shortjournal = {Adv. Sci.}, title = {In situ surface polishing enables VOC approaching 95% of the theoretical limit for efficient inverted perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Customized hydrogel system for the spatiotemporal sequential treatment of periodontitis propelled by ZEB1. ADVS, 12(26), 2503338. (www)

  @article{ , abstract = {Advanced periodontitis initiates with Porphyromonas gingivalis ( P. gingivalis ) infection, which subsequently triggers chronic inflammation, immune imbalance, and ultimately causes alveolar bone resorption. Traditional periodontal treatment focuses on the elimination of triggering factors, but tend to ignore the improvement of the inflammatory microenvironment and the remodeling of the osteogenic mineralization space. Herein, zinc-aluminum layered double hydroxide nanosheets (LDHs) loaded with icariin (ICA) are encapsulated into a gallic acid (GA)-modified hydroxybutyl chitosan hydrogel (GA-HBC), giving rise to a customized hydrogel system named GA-HBC-LIC, which can sequentially actualize antibacterial, anti-inflammatory, and remineralization functions. A neutral chemical-humoral space is created for osteogenesis via means of sequential regulation by the smart hydrogel. Concomitantly, appropriate mechanical properties and degradation performance of the hydrogel provide a desirable physical space for remineralization. In the spatiotemporal modulation of the hydrogel, zinc finger E-box-binding homeobox 1 (ZEB1) target of released zinc ions (Zn 2+ ) action promotes macrophage polarization from M1 to M2 phenotype, thereby remodeling the immune microenvironment and releasing cytokines conducive to tissue regeneration. In sum, this study highlights the critical role of sequential inflammation regulation and the maintenance of osteogenic space in the regeneration of periodontal tissues, offering new insights for the clinical management of periodontitis.}, archive = {J_ADVS}, author = {Jiafei Chen and Xiaoxu Guan and Lina Chen and Bingzhu Zheng and Feiyu Li and Chao Fang and Yike Fu and Xiang Li and Huiming Wang and Yi Zhou}, doi = {10.1002/advs.202503338}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503338}, shortjournal = {Adv. Sci.}, title = {Customized hydrogel system for the spatiotemporal sequential treatment of periodontitis propelled by ZEB1}, volume = {12}, year = {2025}, }
• (2025). Magnetite Micro/Nanorobots for efficient targeted alleviation of inflammatory bowel disease. ADVS, 12(26), 2503307. (www)

  @article{ , abstract = {Millions of people worldwide have inflammatory bowel disease (IBD). Self-driven micro/nanorobots (MNRs) are efficient in the treatment of IBD. However, their lack of controllability regarding direction of motion in the organism and their inability to achieve continuous navigation limits their further application. In this study, polydopamine is wrapped around the magnetite surface, loaded with an anti-inflammatory drug resveratrol, and wrapped with pH-responsive sodium alginate to obtain magnetic MNRs. MNRs can be driven by magnetic fields to achieve directional movement and targeted transportation. In addition, MNRs can effectively remove reactive oxygen species from the inflammation site, repair intestinal damage, inhibit the cellular pathway of pro-inflammatory factors, such as MAPK and NF-κB pathways, and restore intestinal flora, thereby relieving IBDs. MNRs are safe and effective for in vivo treatment of IBD and have proven to be a promising therapeutic platform. This MNRs therapeutic strategy provides new insights into comprehensive IBD therapy.}, archive = {J_ADVS}, author = {Ying Feng and Yang Liu and Linlin Liu and Qian Yang and Miao An and Huaming Yang}, doi = {10.1002/advs.202503307}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503307}, shortjournal = {Adv. Sci.}, title = {Magnetite Micro/Nanorobots for efficient targeted alleviation of inflammatory bowel disease}, volume = {12}, year = {2025}, }
• (2025). Nucleic acid-locked smart carrier for Photothermal/Chemotherapy-amplified immunogenic cell death to enhance systemic antitumor efficacy. ADVS, 12(26), 2503299. (www)

  @article{ , abstract = {Immunotherapy holds great promise in the fight against cancer; however, it often encounters poor immunogenicity with limited therapeutic efficacy. Combining multiple treatment modalities provides a trustworthy strategy for achieving a robust antitumor effect. In this study, a nucleic acid-locked smart carrier (NASC) is developed to amplify immunogenic cell death (ICD) through the synergistic integration of photothermal therapy (PTT) and chemotherapy for high-performance monotherapy. Mesoporous silica-coated gold nanorod (MSGNR) serves as the reservoir for anticancer drug doxorubicin (DOX) and is capped with a sequence-specific duplex unit containing a tumor-specific targeting AS1411 fragment, resulting in the formation of NASC. With AS1411 targeting, the NASC can specifically target and be internalized into tumor cells with high expression of nucleolin, where the duplex capping can be unlocked by the intracellularly overexpressed adenosine triphosphate. Subsequently, the released DOX synergized with MSGNR-mediated PTT following laser irradiation induces direct cell killing, which, concurrently, triggers ICD to activate antineoplastic immunity with an increased number of T lymphocytes. This triple-collaborative strategy, further combined with anti-programmed death-1 antibody (αPD-1)-mediated immune checkpoint blockade (ICB) therapy, shows a robust therapeutic efficacy in both unilateral and bilateral tumor models.}, archive = {J_ADVS}, author = {Jiayang Zhang and Tianyu Gai and Jiwei Wang and Yucai Wu and Si-Ming Zeng and Dongyuan Zhao and Wei Li}, doi = {10.1002/advs.202503299}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503299}, shortjournal = {Adv. Sci.}, title = {Nucleic acid-locked smart carrier for Photothermal/Chemotherapy-amplified immunogenic cell death to enhance systemic antitumor efficacy}, volume = {12}, year = {2025}, }
• (2025). Aerial track-guided autonomous soft ring robot. ADVS, 12(26), 2503288. (www)

  @article{ , abstract = {Navigating in three-dimensional (3D) environments with precise motion control is challenging for soft robots due to their inherent flexibility. Inspired by aerial trams, here, an autonomous soft twisted ring robot is reported capable of navigating pre-defined tracks in 3D space under constant photothermal actuation, without requiring spatiotemporal control of actuation sources. Made of liquid crystal elastomers, the ring robot, suspended on thread-based tracks, self-flips around its centerline when exposed to constant infrared light. Curling the twisted ring around tracks converts its self-rotary motion into autonomous linear movement via screw theory. This mechanism enables the autonomous robot to adapt to tracks of various materials and micron-to-millimeter sizes, overcome obstacles like knots on tracks, transport loads over 12 times its weight, ascend and descend steep slopes up to 80°, and navigate complex paths, including circular, polygonal, and 3D spiral tracks, as well as loose threads with dynamically changing shapes.}, archive = {J_ADVS}, author = {Fangjie Qi and Caizhi Zhou and Haitao Qing and Haoze Sun and Jie Yin}, doi = {10.1002/advs.202503288}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503288}, shortjournal = {Adv. Sci.}, title = {Aerial track-guided autonomous soft ring robot}, volume = {12}, year = {2025}, }
• (2025). Twin toughening-driven martensitic transformation strategy synergistic improvement for plasticity-thermal shock resistance of (Hf─Zr─Ti)C ceramic coating in severe thermal environments. ADVS, 12(26), 2503226. (www)

  @article{ , abstract = {The inherent brittleness and insufficient thermal shock resistance of ultra-high temperature ceramic (UHTC) in severe thermal environments (above 2000 °C) remain significant challenges. This characteristic notably shortens their operational lifespan as thermal protective coatings on structural composites in reusable aerospace applications. To address these challenges, a “ceramic self-toughening strategy” is introduced, aimed at enhancing the plasticity and thermal shock resistance of (Hf─Zr─Ti)C coatings through twin toughening-driven martensitic transformations in the oxide scale. In this work, the oxidation of (Hf 1/2 Zr 1/4 Ti 1/4 )C and (Hf 1/4 Zr 1/2 Ti 1/4 )C coatings produced Ti-doped (Hf 2/3 Zr 1/3 )O 2 and Ti-doped (Hf 1/3 Zr 2/3 )O 2 , with martensitic transformations initiated by “slip band-twin transfer” and “stacking fault-twin transfer”, respectively. The mechanism facilitated the formation of stable, dense, and high-toughness oxide scales after repeat ablation, and then endowed the prepared coatings with superior repeat ablation resistance than current thermal protective coatings. The findings elucidated the role of martensitic transformation mechanisms of Ti-doped (Hf, Zr)O 2 during repeat ablation, and provided general design guidelines for synergistically controlling the component, microstructure, toughness, and thermal shock resistance of UHTC blocks and UHTC-modified composites in severe thermal environments.}, archive = {J_ADVS}, author = {Jiachen Li and Yulei Zhang and Yanqin Fu and Tao Li and Jian Zhang and Deyu Yang and Lingfei Cao and Fanyu Lu and Junhao Zhao and Junshuai Lv and Hejun Li}, doi = {10.1002/advs.202503226}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503226}, shortjournal = {Adv. Sci.}, title = {Twin toughening-driven martensitic transformation strategy synergistic improvement for plasticity-thermal shock resistance of (Hf─Zr─Ti)C ceramic coating in severe thermal environments}, volume = {12}, year = {2025}, }
• (2025). Macrophage WEE1 directly binds to and phosphorylates NF-κB p65 subunit to induce inflammatory response and drive atherosclerosis. ADVS, 12(26), 2503192. (www)

  @article{ , abstract = {Atherosclerosis has an urgent need for new therapeutic targets. Protein kinases orchestrate multiple cellular events in atherosclerosis and may provide new therapeutic targets for atherosclerosis. Here, a protein kinase, WEE1 G2 checkpoint kinase (WEE1), promoting inflammation in atherosclerosis is identified. Kinase enrichment analysis and experimental evidences reveal macrophage WEE1 phosphorylation at S642 in human and mouse atherosclerotic tissues. RNA-seq analysis, combined with experiment studies using mutant WEE1 plasmids, shows that WEE1 phosphorylation, rather than WEE1 expression, mediated oxLDL-induced inflammation in macrophages. Macrophage-specific deletion of WEE1 or pharmacological inhibition of WEE1 kinase activity attenuates atherosclerosis by reducing inflammation in mice. Mechanistically, RNA-seq and co-immunoprecipitation followed by proteomics analysis are used to explore the mechanism and substrate of WEE1. p-WEE1 promoted inflammatory response through activating NF-κB shown and further revealed that WEE1 can directly bind to the p65 subunit. It is confirmed that p-WEE1 directly interacts with the RHD domain of p65 and phosphorylates p65 at S536, thereby facilitating subsequent NF-κB activation and inflammatory response in macrophages. The findings demonstrate that macrophage WEE1 drives NF-κB activation and atherosclerosis by directly phosphorylating p65 at S536. This study identifies WEE1 as a new upstream kinase of p65 and a potential therapeutic target for atherosclerosis.}, archive = {J_ADVS}, author = {Zhuqi Huang and Sirui Shen and Weixin Li and Mengyang Wang and Yudie Yang and Wu Luo and Xue Han and Zheng Xu and Julian Min and Xiaohong Long and Weijian Huang and Gaojun Wu and Yi Wang and Guang Liang}, doi = {10.1002/advs.202503192}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503192}, shortjournal = {Adv. Sci.}, title = {Macrophage WEE1 directly binds to and phosphorylates NF-κB p65 subunit to induce inflammatory response and drive atherosclerosis}, volume = {12}, year = {2025}, }
• (2025). Hydrolyzable bio-based bisphenols enabled by the tishchenko reaction for polyurethane vitrimers with closed-loop recyclability. ADVS, 12(26), 2503152. (www)

  @article{ , abstract = {Polyurethane (PU) is a cornerstone of modern materials science, yet its reliance on petroleum-based precursors and the limited recyclability of conventional formulations pose significant environmental challenges. In this study, a fully bio-based polyurethane vitrimer system is developed enabled by a dual-function SmI 2 -mediated strategy that integrates Tishchenko coupling and phenol deprotection in a single step, simplifying the synthesis of bio-based bisphenols with 100% atom utilization. These bisphenols introduce hydrolyzable ester bonds, allowing for complete degradation within ≈3 d (representative model), providing an efficient and eco-friendly end-of-life solution. This approach offers a sustainable alternative to conventional bisphenol A (BPA). Moreover, by leveraging the electronic effects of bio-based bisphenols, the dissociation temperature of phenol-carbamate bonds can be widely tuned (≈70–120 °C), endowing the resulting Covalent Adaptable Network (CAN) PUs with excellent reprocessability, closed-loop recyclability, and reconfigurable shape memory capability. Furthermore, the aromatic and ester-rich structure enhances thermomechanical performance, yielding tensile strengths up to 33 MPa, elongations at break exceeding 400%, and toughness reaching 30 MJ m − 3 , surpassing most sustainable PUs. This work pioneers a scalable and fully bio-based PU vitrimer platform with tunable performance, recyclability, and sustainable degradability, offering a compelling alternative to traditional thermosets and thermoplastics for next-generation green materials.}, archive = {J_ADVS}, author = {Jiewen Wang and Hongru Qiang and Rong Huang and Dan Zhao and Zihan Tong and Zhen Fan and Jianzhong Du and Yunqing Zhu}, doi = {10.1002/advs.202503152}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503152}, shortjournal = {Adv. Sci.}, title = {Hydrolyzable bio-based bisphenols enabled by the tishchenko reaction for polyurethane vitrimers with closed-loop recyclability}, volume = {12}, year = {2025}, }
• (2025). Cancer specific CAIX-targeting supramolecular lysosome-targeting chimeras (Supra-LYTAC) for targeted protein degradation. ADVS, 12(26), 2503134. (www)

  @article{ , abstract = {Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable proteins. While most TPD strategies target intracellular proteins, limited options exist for targeting extracellular or membrane proteins. Herein, cancer specific carbonic anhydrase IX (CAIX)-targeting supramolecular nanofibrous lysosome-targeting chimeras (Supra-LYTAC) is reported. Two self-assembling amphiphilic peptides are synthesized: one that interacts with the protein of interest (POI), and another that mediates lysosomal endocytosis by targeting a cancer-specific enzyme. Notably, these two peptides co-assemble into nanofibers capable of targeting cancer cells in a spatiotemporal manner. Through dynamic and multivalent binding, a ternary complex form (supramolecular chimeric nanostructure; CAIX-nanofiber-POI), which undergoes internalization into lysosomes where the POI is degraded through lysosomal catalytic activity. This study demonstrates the potential of supramolecular approaches to expand the scope of LYTAC technology, offering new opportunities for designing TPD strategies in the future.}, archive = {J_ADVS}, author = {Dohyun Kim and Gyeongseok Yang and Chaelyeong Lim and Gaeun Park and Jaemo Lee and Youjung Sim and Ja-Hyoung Ryu}, doi = {10.1002/advs.202503134}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503134}, shortjournal = {Adv. Sci.}, title = {Cancer specific CAIX-targeting supramolecular lysosome-targeting chimeras (Supra-LYTAC) for targeted protein degradation}, volume = {12}, year = {2025}, }
• (2025). Modulating the evolution of metastable CaO* for the near-theoretical performance breakthrough of Ni/CeO2-CaO in integrated CO2 capture and methanation. ADVS, 12(26), 2503086. (www)

  @article{ , abstract = {Integrated CO 2 capture and utilization technology based on the calcium looping is burgeoning as an economical and viable strategy for achieving Carbon Neutrality. However, the drawback of easy sintering of CaO limits its potential to maximize CO 2 capture and conversion. Here, a low-temperature hydrogen spillover decomposition strategy is proposed to synthesize high-performance CaO-based dual-functional material. This strategy significantly shortens the existence time of the transition state CaO*, enabling CaCO 3 to be converted into CaO more rapidly. Compared with the traditional sol–gel method, the sintering of CaO is more effectively inhibited. Specifically, NiCa-400 achieves a CO 2 capture of 17.8 mmol g −1 (theoretical value of 17.8 mmol g −1 ), a CH 4 yield of 17.2 mmol g −1 (192% higher than the conventional method), and a CH 4 selectivity of 97%. In addition, scale-up experimental studies further demonstrated its practical scalability. Guided by techno-economic analysis, coupling the proposed strategy with a coal-fired power plant can reduce energy consumption by 79% and save investment costs by 23% compared with a conventional carbon capture and utilization (CCU). This work bridges the gap between the actual and theoretical properties of traditional calcium-based dual-functional materials and provides a new solution for the high-value utilization of carbonates.}, archive = {J_ADVS}, author = {Lifei Wei and Rui Han and Gaoqi Han and Han Yan and Mingke Peng and Zhiyong Li and Chunfeng Song and Qingling Liu}, doi = {10.1002/advs.202503086}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503086}, shortjournal = {Adv. Sci.}, title = {Modulating the evolution of metastable CaO* for the near-theoretical performance breakthrough of Ni/CeO2-CaO in integrated CO2 capture and methanation}, volume = {12}, year = {2025}, }
• (2025). Inverse design of active-source metamaterials for thermal camouflage with arbitrary active sources. ADVS, 12(26), 2503024. (www)

  @article{ , abstract = {Precise control of active-source thermal fields is critical for advanced technological applications, including thermal camouflage, thermal protection, and energy harvesting. However, the inherent heat generation from active sources often results in localized high-temperature regions and complex, non-linear heat flux distributions, posing significant challenges for effectively managing these thermal fields. Here, a novel theoretical design framework is presented for active-source metamaterials (ASM) by integrating inverse design principles with advanced transformation thermotics. This ASM framework allows for the conversion of complex active-source effects into tailored anisotropic thermal conductivity distributions, thus enabling precise modulation of active-source thermal fields for a variety of advanced applications. As a proof-of-concept, the precise thermal camouflage of active sources is demonstrated, ranging from simple circular geometries to more complex multi-leaf configurations, and systematically investigate the interactions between the temperature fields, heat flux distributions, and the power of active sources. Both numerical simulations and experimental validations are conducted to substantiate the effectiveness of the proposed approach. The work establishes a versatile framework for the precise management of active-source thermal fields, offering significant potential for applications in fields such as chip design, battery technology, and energy systems.}, archive = {J_ADVS}, author = {Xianrong Cao and Zifeng Tong and Yongle Nian and Jiachang Li and Yinuo Zhou and Zihao Zhang and Yixin Liu and Lei Gong and Zhengdong Cheng and Liqun He}, doi = {10.1002/advs.202503024}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503024}, shortjournal = {Adv. Sci.}, title = {Inverse design of active-source metamaterials for thermal camouflage with arbitrary active sources}, volume = {12}, year = {2025}, }
• (2025). Layered iron vanadate for high-performance and stable cathode material for aqueous manganese batteries. ADVS, 12(26), 2503006. (www)

  @article{ , abstract = {Aqueous rechargeable metal batteries have gained significant attention because of the low cost, high capacity, and inherent safety offered by nonflammable water-based electrolytes. Among these, Mn-based systems are promising owing to their intrinsic stability, abundance, affordability, and high energy density. Despite these advantages, the development of suitable host structures for Mn storage remains underexplored. This study introduces layered iron vanadate, FeV 3 O 9 ·1.1H 2 O, as a new cathode material for aqueous Mn batteries, demonstrating exceptional performance. The cathode exhibits a reversible capacity of 306.9 mAh g −1 at 0.25 A g −1 and an excellent rate performance of 210.6 mAh g −1 at 2 A g −1 . In addition, FeV 3 O 9 ·1.1H 2 O exhibits outstanding cycling stability, retaining 73.4% of its initial capacity after 3000 cycles at 3 A g − ¹, which is attributed to its low layered volume expansion. The underlying reaction mechanism is elucidated through spectroscopic and microscopic analyses. When integrated into the final Mn cell, the cathode system demonstrates superior performance compared to Zn batteries, underscoring its potential for next-generation aqueous battery systems. These findings advance the aqueous Mn battery technology, paving the way for safer, more cost-effective, and high-performance energy storage solutions.}, archive = {J_ADVS}, author = {Seunghyeop Baek and Dedy Setiawan and Hyeonjun Lee and Sangki Lee and Jangwook Pyun and Seung-Tae Hong and Munseok S. Chae}, doi = {10.1002/advs.202503006}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2503006}, shortjournal = {Adv. Sci.}, title = {Layered iron vanadate for high-performance and stable cathode material for aqueous manganese batteries}, volume = {12}, year = {2025}, }
• (2025). Bandgap engineering on UiO–66 metal-organic framework derivatives for solar-driven seawater desalination. ADVS, 12(26), 2502989. (www)

  @article{ , abstract = {The growing scarcity of freshwater, driven by climate change and pollution, necessitates the development of efficient and sustainable desalination technologies. Solar-powered interfacial water evaporation has emerged as a promising solution; however, its practical implementation is hindered by the limited availability of efficient and stable photothermal materials. Herein, a bandgap engineering strategy via linker modification to enhance the photothermal conversion capability of metal-organic frameworks (MOFs) is reported toward efficient solar-driven desalination. By systematically introducing functional groups with varying electron-donating and electron-withdrawing abilities, the energy bandgap of UiO–66–X (X = ─F, ─H, ─OH, ─NH 2 , ─(NH 2 ) 2 ) is finely tuned. Density functional theory (DFT) calculations and femtosecond transient absorption (fs–TA) spectroscopy reveal that stronger electron-donating functional groups narrow the bandgap of the MOFs, thereby improving their photothermal conversion efficiency. The optimized UiO–66–(NH 2 ) 2 material reaches a peak surface temperature of 58.7 °C when exposed to simulated sunlight at ≈1 kW·m −2 with a photothermal conversion efficiency of 86.50% and an evaporation rate of 2.34 kg·m −2 ·h −1 with an evaporation efficiency of 97.40%. This study presents a novel approach for fine-tuning the bandgap in photothermal materials, offering a pathway toward advanced solar desalination technologies to address the global water scarcity crisis.}, archive = {J_ADVS}, author = {Qisheng Shao and Yutong Ding and Wenxian Liu and Jia Guan and Ge Meng and Tairong Kuang and Dingsheng Wang}, doi = {10.1002/advs.202502989}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502989}, shortjournal = {Adv. Sci.}, title = {Bandgap engineering on UiO–66 metal-organic framework derivatives for solar-driven seawater desalination}, volume = {12}, year = {2025}, }
• (2025). Fragment autoantigens stimulated T-cell-immunotherapy (FAST) as a fast autologous cancer vaccine. ADVS, 12(26), 2502937. (www)

  @article{ , abstract = {Tumor cells often down-regulate antigen presentation and mount an immunosuppressive microenvironment, hindering successful cancer immunotherapy and vaccine development. Additionally, due to genomic instability, tumor cells are usually heterogeneous and constantly evolving. Therefore, vaccines need broad antigen coverage and rapid preparation. Here, a personalized whole tumor cell vaccine (TCV), termed fragment autoantigens stimulated T-cell-immunotherapy (FAST) is developed. In 7 h, tumor cells are treated with irradiation and cryoablation. Personalized fragmented antigens (FAs) from these treated cells are used as TCVs. In breast, colon, and melanoma mouse models, FAST achieved significant tumor regression, less metastasis, and longer survival. Notably, FAST outperforms other advanced TCVs, especially in curbing metastasis. Mechanistically, FAs activate efficient, broad-spectrum antigen presentation due to upregulation of immunogenic cell death, MHC-I, and damage-associated molecular patterns. Concurrently, FAST also enhances anti-tumor immunity by reshaping immune microenvironments. Analysis of clinical data shows FAST-associated proteins have prognostic and therapeutic value in patients with liver, stomach, rectal cancers, and melanoma. These results suggest FAST has high anti-tumor efficacy and potential as a personalized TCV platform. The relevant clinical trial NCT06756295 is under initiation with approval of ethics.}, archive = {J_ADVS}, author = {Yuan Li and Huiqin Chen and Qiaofeng Shen and Yingshuang Liu and Pingping Li and Yuqi Ma and Yugang Wang and Shengkai Li and Xueqing Yan and Liyu Liu and Jianwei Shuai and Min Wu and Qi Ouyang and Feng-Ming (Spring) Kong and Gen Yang}, doi = {10.1002/advs.202502937}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502937}, shortjournal = {Adv. Sci.}, title = {Fragment autoantigens stimulated T-cell-immunotherapy (FAST) as a fast autologous cancer vaccine}, volume = {12}, year = {2025}, }
• (2025). Super-heterostructures of twisted pd nanoarrays epitaxially grown on chiral au nanorods boost circularly polarized photocatalysis. ADVS, 12(26), 2502848. (www)

  @article{ , abstract = {Seed-mediated growth provides an efficient way to produce chiral hybrid nanocrystals, mainly benefitting from the recent successful synthesis of discrete chiral metal nanocrystals. However, the chiroptical response of chiral core-shell nanostructures decreases rapidly when the functional layer is grown on the discrete chiral metal nanocrystals. Herein, a synthetic methodology is demonstrated for the formation of chiral Au@Pd super-heterostructures, in which Pd nanoarrays are epitaxially and densely grown with a twisted lattice on discrete chiral Au nanorods (Pd-on-cAuNRs). The highly aligned Pd nanoarrays on cAuNRs exhibit good chiroptical performance. Importantly, the Pd-on-cAuNR super-heterostructures display chiral behavior in their catalytic actions, with the catalytic performance of D-super-heterostructures being twice higher than that of its L- super-heterostructures. In addition, under circularly polarized light (CPL) irradiation, the chiral electromagnetic field and hot electrons generated on the chiral super-heterostructures boost circularly polarized photocatalytic activity, the mechanism of which is supported by theoretical simulations and chiral photocurrent experiments. This research work offers fundamental insights on chiral surface plasmon resonance-induced photocatalysis and rational design of chiral nanostructure photocatalysts.}, archive = {J_ADVS}, author = {Taotao Luo and Haoyu Li and Zhicheng Zhang and Shenli Wang and Xiaobin Pan and Stefanos Mourdikoudis and Chao Xue and Junjun Li and Kwok-Yin Wong and Guangchao Zheng}, doi = {10.1002/advs.202502848}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502848}, shortjournal = {Adv. Sci.}, title = {Super-heterostructures of twisted pd nanoarrays epitaxially grown on chiral au nanorods boost circularly polarized photocatalysis}, volume = {12}, year = {2025}, }
• (2025). Oxygen-doped MoS2 with expanded interlayer spacing for rapid and stable polysulfide conversion. ADVS, 12(26), 2502834. (www)

  @article{ , abstract = {Lithium–sulfur batteries face challenges such as the polysulfide shuttle effect and sluggish redox kinetics, leading to poor sulfur utilization and limited cyclic stability. Herein, an oxygen-doped engineering approach is presented to achieve pillar-free interlayer extension of MoS 2 (E-MoS 2 ) for lithium polysulfide conversion. E-MoS 2 features expanded interlayer spacing (from 0.63 to 0.95 nm), improved conductivity, and an optimized Mo d band center, which collectively enhances polysulfide conversion efficiency. Consequently, cathodes with E-MoS 2 deliver a capacity of 638 mAh g −1 after 600 cycles at 2 C (0.046% decay/cycle) and an areal capacity of 12.0 mAh cm −2 under practical conditions (12 mg cm −2 S loading, E/S = 4 µL mg −1 ). This work highlights interlayer engineering as a key strategy for optimizing MoS 2 catalysts in conversion-type batteries.}, archive = {J_ADVS}, author = {Wenqi Yan and Jinglin Xian and Shunan Zhang and Jiarui Zhang and Kaisi Liu and Jin-Lin Yang and Feng Tao and Ruiping Liu and Qi Liu and Peihua Yang}, doi = {10.1002/advs.202502834}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502834}, shortjournal = {Adv. Sci.}, title = {Oxygen-doped MoS2 with expanded interlayer spacing for rapid and stable polysulfide conversion}, volume = {12}, year = {2025}, }
• (2025). Superelastic and ultra-soft MXene/CNF Aerogel@PDMS-based dual-modal pressure sensor for complex stimuli monitoring. ADVS, 12(26), 2502797. (www)

  @article{ , abstract = {In the face of complex pressure stimuli, pressure sensor is required to sense the magnitude of static force and sensitive to transient mechanical stimuli. However, an individual sensing mechanism has difficulty meeting practical needs simultaneously. In this work, an MXene/cellulose nanofiber (CNF) aerogel@PDMS-based dual-modal pressure sensor is reported for complex stimuli monitoring. The aerogel-based sensing material is fabricated through MXene nanosheets and CNFs. Aerogel ice crystals sublimate and then form a 3D porous structure during vacuum freeze-drying. After attaching PDMS dilution, aerogels achieve >200 reversible compressions, and hysteresis energy is reduced by 57.8%. By utilizing both triboelectric and piezoresistive properties of MXene/CNF aerogel@PDMS, a dual-modal pressure sensor is achieved. The triboelectric effect acquires high sensitivity of 26.95 kPa −1 under low pressure (3.46 Pa–3.32 kPa) and responds to vibrations up to 1000 Hz. On the basis of variable resistances of aerogels, the piezoresistive effect can be used to identify static pressures stably (167 kPa −1 , 1.56–26.64 kPa). Combining two effects broadens the lower limit of high-sensitivity monitoring, realizing static-dynamic detection simultaneously and breaking the frequency limit of piezoresistive materials. Finally, the dual-modal pressure sensor is demonstrated to monitor complex physiological and physical signals, such as pronunciation, gestures, and tone recognition.}, archive = {J_ADVS}, author = {Ao Wang and Zhenqiu Gao and Shaokuan Wu and Yihan Wei and Bohan Lu and Jia Shi and Lanyue Shen and Yina Liu and Xuhui Sun and Zhen Wen}, doi = {10.1002/advs.202502797}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502797}, shortjournal = {Adv. Sci.}, title = {Superelastic and ultra-soft MXene/CNF Aerogel@PDMS-based dual-modal pressure sensor for complex stimuli monitoring}, volume = {12}, year = {2025}, }
• (2025). Anion-vacancy activated vanadium sulfoselenide with in-plane heterostructure enabling durable and wide-temperature zinc-ion batteries. ADVS, 12(26), 2502745. (www)

  @article{ , abstract = {Zinc-ion batteries (ZIBs) represent a promising energy-storage device, which has remarkable merits in terms of cost-effectiveness, high safety, and environmental sustainability. Transition metal chalcogenides are emerging cathode materials for ZIBs due to their high theoretical capacity and large interlayer spacing. Nevertheless, their application faces critical challenges of sluggish reaction kinetics and huge volume variation. Herein, the anion defect engineering strategy for one-step in situ anchoring vanadium sulfoselenide on V 2 CT x template (VSSe/V 2 CT x ) in-plane heterostructure with built-in anion vacancy is proposed by robust interfacial C─Se─V bonds to overcome these challenges. The incorporation of the Se atom into VS 2 not only changes the metal V atom electronic structure and enhances the intrinsic electrical conductivity of VSSe/V 2 CT x , but also creates more active sites and accelerates the reaction kinetics as confirmed by theoretical calculations and experimental results. Thus, the VSSe/V 2 CT x cathode delivers a high capacity of 114.3 mAh g −1 at 5 A g −1 over 15 000 cycles under cryogenic conditions in quasi-solid state ZIBs (QSSZIBs). Furthermore, the two QSSZIBs successfully integrated with a hydrogel strain sensor enabling reliable human motion and physiological signal detection, highlighting the promise of VSSe/V 2 CT x cathode for self-powered wearable healthcare monitoring and management systems.}, archive = {J_ADVS}, author = {Zhong-Hui Sun and Wei Zheng and Rui Zheng and Zhen-Yi Gu and Yu Bao and Zhen-Bang Liu and Zhong-Bo Sun and Li Niu and Xing-Long Wu}, doi = {10.1002/advs.202502745}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502745}, shortjournal = {Adv. Sci.}, title = {Anion-vacancy activated vanadium sulfoselenide with in-plane heterostructure enabling durable and wide-temperature zinc-ion batteries}, volume = {12}, year = {2025}, }
• (2025). A smart single-loop-mediated isothermal amplification facilitates flexible SNP probe design for on-site rapid differentiation of SARS-CoV-2 omicron variants. ADVS, 12(26), 2502708. (www)

  @article{ , abstract = {Rapid on-site typing methods for SARS-CoV-2 variants of concern are crucial for its effective surveillance and control. Herein, a smart single-loop-mediated isothermal amplification (ssLAMP) method with the absence of an inner primer but the addition of a swarm primer for differentiation of SARS-CoV-2 Omicron variants is developed. This unique primer design strategy offers greater flexibility in introducing single nucleotide polymorphism (SNP) identification probes and enables multiple detection assays for SARS-CoV-2 Omicron variants including BA.1, BA.2, BA.3, BA.4, and BA.5. A 3D-printed portable dual fluorescence visualization device and smartphone app are developed to enable point-of-care testing. This assay is rapid (within 90 min), highly sensitive (100 copies/reaction), and specific (identification of SNP) for SARA-CoV-2 Omicron variants. The ssLAMP method identifies five BA.5-positive samples among 97 nasopharyngeal swab samples from the clinic, with a 100% concordance rate with Sanger sequencing. The ssLAMP assay system is expected to be utilized for on-site, highly specific, and rapid visualization detection of SARS-CoV-2 and its variants, with great application potential in pathogen genotyping, early cancer screening, and other areas of SNP mutation detection.}, archive = {J_ADVS}, author = {Qijie Lin and Hongchao Gou and Xiaoyun Qu and Kaiyuan Jia and Yuhui Deng and Dan Li and Qianyi Cai and Yucen Liang and Xiaozhen Xu and Yanbin Li and Jianhan Lin and Letian Li and Yuhang Jiang and Shouwen Du and Lingcong Deng and Bailing Yan and Ruidong Liu and Chang Li and Jianmin Zhang and Ming Liao}, doi = {10.1002/advs.202502708}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502708}, shortjournal = {Adv. Sci.}, title = {A smart single-loop-mediated isothermal amplification facilitates flexible SNP probe design for on-site rapid differentiation of SARS-CoV-2 omicron variants}, volume = {12}, year = {2025}, }
• (2025). Dynamic molecular cocrystals with alkyl chain dependent thermosalient phase transitions. ADVS, 12(26), 2502692. (www)

  @article{ , abstract = {Thermally responsive molecular crystals exhibiting programmable mechanical motions hold significant promise for applications in smart actuators, sensors, and drug delivery systems. However, achieving precise control over their phase transition thermodynamics remains a fundamental challenge. A series of isomorphic 5-fluorocytosine/fatty acid cocrystals is reported where the phase transition temperatures vary across an interval of 100 K with increasing alkyl chain. Two distinct transition pathways are unveiled: i) a cooperative single-crystal-to-single-crystal transition (II-III) accompanied by explosive mechanical motions, and ii) a reconstructive transition (I-III) following classical nucleation-growth mechanisms. The cooperative phase transition (II-III) induces remarkable expansion, with a striking +64.4% expansion along the layer stacking direction and a −16.9% contraction perpendicular to the (001) plane, leading to dynamic phenomena such as jumping, rotating, and splitting. Notably, the transition temperatures ( T t, II-III ) exhibit linear dependence on coformer chain length (from C10 to C18), a correlation attributed to interlayer hydrophobic interactions. This work provides a versatile approach for designing molecular crystals with tunable thermo-mechanical properties, offering new opportunities for advanced applications in dynamic functional materials.}, archive = {J_ADVS}, author = {Jiantao Meng and Yuan Su and Hang Zhu and Jie Zhang and Ting Cai}, doi = {10.1002/advs.202502692}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502692}, shortjournal = {Adv. Sci.}, title = {Dynamic molecular cocrystals with alkyl chain dependent thermosalient phase transitions}, volume = {12}, year = {2025}, }
• (2025). Cartilage-penetrating framework nucleic acid nanoparticles ameliorate osteoarthritis by promoting drug delivery and chondrocyte uptake. ADVS, 12(26), 2502661. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a chronic joint disease that causes a gradual deterioration of articular cartilage. A major challenge in OA treatment is the limited penetration and delivery efficiency of drugs to cartilage and chondrocytes due to the rapid clearance of drugs through synovial fluid in joints and the osmotic barrier of the cartilage extracellular matrix (ECM). To address this issue, a novel tetrahedral framework nucleic acid (tFNA)-based nanomedicine delivery system (tFNA-2WL) is first synthesized with excellent cartilage permeability and perfect chondrocyte endocytosis properties. After being loaded with ginsenoside Rb1 (Gin), the tFNA-2WL&Gin complex not only penetrates the cartilage but also accumulates in the menisci, ligaments, and joint capsules, thus prolonging the residence time of Gin in OA rat knees. In vitro, tFNA-2WL&Gin effectively promotes chondrogenesis, inhibits cartilage degradation by reducing apoptosis, and scavenges reactive oxygen species (ROS), outperforming free Gin. In OA rats, tFNA-2WL&Gin restores gait, reduces osteophyte formation, inhibits synovial inflammation and hypertrophy, and protects cartilage from further damage more effectively than Gin and other nanomedicines. These results demonstrate the feasibility of tFNA-2WL in improving the pharmacokinetics and efficacy of drugs and highlight the favorable curative effects of tFNA-2WL&Gin for OA, offering a promising paradigm for translational medicine.}, archive = {J_ADVS}, author = {Kui Huang and Qiumei Li and Huixuan Lin and Qian Shen and Yaping Wu and Taoran Tian and Chuan Ma and Sirong Shi and Jingang Xiao and Yunfeng Lin}, doi = {10.1002/advs.202502661}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502661}, shortjournal = {Adv. Sci.}, title = {Cartilage-penetrating framework nucleic acid nanoparticles ameliorate osteoarthritis by promoting drug delivery and chondrocyte uptake}, volume = {12}, year = {2025}, }
• (2025). Separating the role of mixing-entropy on the dynamics of glass-forming liquids. ADVS, 12(26), 2502568. (www)

  @article{ , abstract = {While the concept of high entropy has gained prominence in materials design, disentangling specific impacts of entropy on material properties from the enthalpy of mixing remains elusive. It is demonstrated that the role of entropy can be distinguished from the dynamics of glass-forming liquids through micro-alloying. Based on experiment analysis of 79 compositions, liquid fragility is found to consistently decreases under two conditions: i) when the alloying content x is minimal, irrespective of the elements used; or ii) when increasing the diversity of alloying elements at a constant x , namely the high-entropy micro-alloying. These observations are consistent with thermodynamic principles that favor an entropy-dominated regime over enthalpy. These findings elucidate the subtle impact of mixing entropy on material properties and provide evidence of the entropy nature of glass transition.}, archive = {J_ADVS}, author = {Qing-Zhou Bu and Jia-Xin Zhang and Hui-Ru Zhang and Ran Li and Tao Zhang and Lin Liu and Peng Yu and Hai-Bin Yu}, doi = {10.1002/advs.202502568}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502568}, shortjournal = {Adv. Sci.}, title = {Separating the role of mixing-entropy on the dynamics of glass-forming liquids}, volume = {12}, year = {2025}, }
• (2025). Nano/Micro metal-organic framework-derived porous carbon with rich nitrogen sites as efficient iodine hosts for aqueous zinc-iodine batteries. ADVS, 12(26), 2502563. (www)

  @article{ , abstract = {Nowadays, the low cost, superior safety, and long durability of aqueous zinc–iodine (Zn–I 2 ) batteries have garnered significant interest. Nevertheless, their practical use is limited by the inferior conductivity of iodine and the shuttle effect, resulting in suboptimal electrochemical behavior. In this work, a nano/micro zinc-based metal-organic framework (Zn-MOF) featuring a cubic morphology is employed for obtaining porous nitrogen-doped carbon (NC), which is reported as a cathode host for Zn–I 2 batteries. Thanks to its porous architecture and high conductivity of NC, the optimized S3-1000 material achieves high iodine loading and enables rapid electron/ion transport. More importantly, the adsorption experiments combined with density functional theory (DFT) calculations reveal that the graphitic-N and pyridine-N moieties within the carbon matrix synergistically serve as active anchoring sites for iodine species, suppress polyiodide shuttle effects and accelerate redox kinetics during iodine conversion. As a result, the I 2 @S3-1000 cathode achieves the highest specific capacity and superior cycle stability over 10,000 cycles, while in-situ characterization analysis confirms the reversible electrochemical mechanism. Soft pack battery and prototype flexible micro-battery based on the I 2 @S3-1000 cathode are also fabricated and show excellent flexibility. This study promotes the development of MOF-derived carbon as iodine cathodes for advanced Zn–I 2 batteries.}, archive = {J_ADVS}, author = {Yong Li and Xiaotian Guo and Shixian Wang and Wenzhuo Sun and Dianheng Yu and Nana Li and Huijie Zhou and Xiaoxing Zhang and Huan Pang}, doi = {10.1002/advs.202502563}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502563}, shortjournal = {Adv. Sci.}, title = {Nano/Micro metal-organic framework-derived porous carbon with rich nitrogen sites as efficient iodine hosts for aqueous zinc-iodine batteries}, volume = {12}, year = {2025}, }
• (2025). Mechanistic insights into the structural evolution of ZIF-67 via electrospinning strategy toward high electromagnetic wave absorption performance of ZIF-67-derived carbon nanofibers. ADVS, 12(26), 2502560. (www)

  @article{ , abstract = {Metal-organic framework (MOF)-derived architectures are regarded as an effective electromagnetic wave (EMW)-absorbing materials owing to their adjustable compositions and microstructures. The combination of MOFs with carbon nanofibers (CNFs) is a practical method to increase the EMW absorption ability. In this work, cobalt-based zeolitic imidazolate framework-67 (ZIF-67) serves as a self-sacrificing precursor to fabricate Co-carbon nanofiber (Co-CNF) composites via an in situ electrospinning strategy. Comparative studies on ex situ and in situ, electrospinning strategies for EMW absorption are conducted. A unique structural evolution mechanism from ZIF-67 to Co nanoparticles is explored. Numerous small Co nanoparticles are evenly distributed on the surface of in situ synthesized Co-CNF (in-Co-CNF) resulting from the collapse of the ZIF-67 framework, whereas the ZIF-67 framework remains on the surface of ex situ synthesized Co-CNF (ex-Co-CNF), encapsulating large Co nanoparticles. A lower reflection loss ( RL ) of −48.6 dB at 6.8 GHz with 3.5 mm is achieved for the in-Co-CNF because of the improved conduction, polarization, and magnetic losses, whereas the ex-Co-CNF only exhibits an RL of −18.3 dB at 9.3 GHz with the same thickness. A radar cross-section (RCS) simulation and a Tesla wireless transmission experiment are conducted to validate the EMW absorption of Co-CNF composites in real applications.}, archive = {J_ADVS}, author = {Xinhui Cao and Xinyi Wu and Xue Wang and Jiamei Luo and Zhe Zhang and Yi Xue and Guoliang Zhang and Liying Zhang and Hui Zhang and Jianyong Yu}, doi = {10.1002/advs.202502560}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502560}, shortjournal = {Adv. Sci.}, title = {Mechanistic insights into the structural evolution of ZIF-67 via electrospinning strategy toward high electromagnetic wave absorption performance of ZIF-67-derived carbon nanofibers}, volume = {12}, year = {2025}, }
• (2025). Unusual thermal transport in few-layer van der waals antiferromagnet CrOCl. ADVS, 12(26), 2502440. (www)

  @article{ , abstract = {Few-layer van der Waals magnets are exceptional candidates for investigating the fundamental spin behaviors and advancing the development of next-generation ultra-compact spintronic devices. While the intrinsic long-range magnetic order is well-established in the monolayer limit, the thermal transport behavior involving magnons, phonons, and magnetophonon polarons near the phase transition remains largely unexplored. In this work, the thermal transport behavior is probed near the phase transitions from bulk to the monolayer limit by using a differential suspended thermal bridge method, which provides an ultra-sensitive temperature and thermal conductance measurement enhanced by the double Wheatstone bridge. In the few-layer CrOCl flake, a stronger magnon-phonon coupling is observed compared to the bulk, resulting in a shift in the thermal transport behavior from a dip to a peak shape around the Néel temperature. Additionally, below the Néel temperature, the few-layer CrOCl significantly enhances the interfacial thermal conductance between the metal electrode and insulator substrate, potentially leading to the substantial improvements in the heat dissipation in Si-based semiconductor devices. This study introduces a novel method and strategy for probing the fundamental magnetic phase transition behavior and lays a solid foundation for the potential application of van der Waals magnets in the electronic devices.}, archive = {J_ADVS}, author = {Yu Yang and Yan Zhou and Ziming Tang and Yulu Liu and Weimin Quan and Jun Zhou and Xiaokang Li and Xiaoxiang Xi and Qihua Gong and Lifa Zhang and Yunshan Zhao}, doi = {10.1002/advs.202502440}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502440}, shortjournal = {Adv. Sci.}, title = {Unusual thermal transport in few-layer van der waals antiferromagnet CrOCl}, volume = {12}, year = {2025}, }
• (2025). Unlocking the potential of photoelectrochemical water splitting via heterointerface charge polarization. ADVS, 12(26), 2502384. (www)

  @article{ , abstract = {The coupling of semiconductor (SC) and transition metal oxyhydroxide (TMOOH) is a promising approach for solar fuel production. However, the inevitable interfacial charge recombination and sluggish oxygen evolution reactions severely hinder the application of photoelectrochemical (PEC) device. This study demonstrates an innovative charge polarization strategy that simultaneously enhances both long-range charge transfer and surface catalytic reaction dynamics through the rational construction of CoO x /MnO x heterointerface in SC/TMOOH system. Kelvin probe force microscopy, in situ ultraviolet/visible spectroelectrochemistry, and density functional theory calculations indicate that the tunable charge polarization of Co δ− and Mn δ+ can affect influences the SC/TMOOH and TMOOH/electrolyte interfaces, primarily through inducing the accelerated charge transfer dynamics ( K h ) and diminishing the adsorption of oxygen-containing intermediates. As anticipated, the BiVO 4 /CoO x /MnO x /FeNiOOH exhibits an impressive photocurrent of 6.75 mA cm −2 at 1.23 V RHE , along with a superior photostability. Furthermore, the smart approach can also be harnessed in the BiVO 4 /CoO x /CeO x /FeNiOOH photoanode. This study provides a novel polarization strategy for the design of optimal photoanodes for PEC water splitting.}, archive = {J_ADVS}, author = {Li Xu and Xingming Ning and Jingjing Quan and Chenglong Li and Lan Yao and Qiang Weng and Pei Chen and Zhongwei An and Xinbing Chen}, doi = {10.1002/advs.202502384}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502384}, shortjournal = {Adv. Sci.}, title = {Unlocking the potential of photoelectrochemical water splitting via heterointerface charge polarization}, volume = {12}, year = {2025}, }
• (2025). A universal approach to anchoring chromophores onto magnetic scaffold for achieving easily recyclable heterogeneous photocatalytic systems. ADVS, 12(26), 2502342. (www)

  @article{ , abstract = {Photocatalysis based on chromophores such as porphyrin, coumarin, anthraquinone, and pyrene is a promising technology to achieve green synthesis of various high-value chemicals, but the robust and non-covalent immobilization of chromophores onto light-inert scaffolds for industrialization-oriented heterogeneous photocatalysis remains challenging. In this work, a simple and universal strategy is presented for preparing highly efficient and recyclable heterogeneous photocatalysts from chromophores, which is achieved via biotinylation of chromophore molecules and subsequent supramolecular binding of chromophore-biotin dyads to streptavidin-decorated magnetic beads. As an example, commercial magnetic beads modified by 5,10,15,20-tetrakis(4-aminophenyl) porphyrin not only possessed remarkable photocatalytic activities for the oxidative coupling of benzylamine derivatives and the oxidation of thioanisole derivatives with highest product yields of beyond 95% and turnover numbers approaching 10000, driven by photogenerated reactive oxygen species but also demonstrated impressive chemical stability and efficient recyclability via simple magnetic separation during 10 successive test cycles. The findings revealed in this work pave the way for advancing green synthesis of valuable organic compounds in the pharmaceutical industry, agricultural sector, etc., with rationally designed heterogeneous photocatalytic systems.}, archive = {J_ADVS}, author = {Xuan Zhan and Yikun Wang and Chenyang Sun and Yuchen Fang and Lihua Huang and Zakir Ullah and Qiang Chen and Xuejing Wang and Zheng Xing and Gangfeng Ouyang}, doi = {10.1002/advs.202502342}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502342}, shortjournal = {Adv. Sci.}, title = {A universal approach to anchoring chromophores onto magnetic scaffold for achieving easily recyclable heterogeneous photocatalytic systems}, volume = {12}, year = {2025}, }
• (2025). Squaraine dyes for organic photomultiplication photodetectors with 220% external quantum efficiency at 1240 nm. ADVS, 12(26), 2502320. (www)

  @article{ , abstract = {Near-infrared (NIR) light detection at wavelengths λ > 1100 nm is essential in modern science and technology. Emerging organic semiconductors are promising for solution-processed, flexible, and large-area NIR organic photodetectors (OPDs), but only a few organic chromophores with peak absorption beyond the silicon bandgap are available. Furthermore, the external quantum efficiency (EQE) and specific detectivity (D * ) of NIR OPDs are restricted by insufficient exciton dissociation and high dark/noise current. Here, the combination of strong electron-accepting and -donating groups is used to synthesize a selection of novel NIR squaraine dyes with superior redshifted absorptions, peaking at 1165 nm in solution and extending to 1240 nm in a blend film. To overcome the tradeoff between long wavelength absorption and high photoresponse, NIR photons are detected utilizing a gain OPD design, where photomultiplication occurs via squaraine hole trap-induced injection of external charges. The OPD can achieve an EQE of 220% at 1240 nm and still maintains 25% in the absorption tail at 1400 nm, thereby surpassing existing NIR OPDs in a broad wavelength range beyond 1100 nm. The measured maximum D * equals 10 9 Jones at 1240 nm, and the detectivity estimated from the shot noise is ≈10 11 Jones, independent of the bias voltage.}, archive = {J_ADVS}, author = {Joshua Csucker and Elodie Didier and João Pedro Ferreira Assunção and Daniel Rentsch and Radha Kothandaraman and Dominik Bachmann and Ivan Shorubalko and Frank Nüesch and Roland Hany and Michael Bauer}, doi = {10.1002/advs.202502320}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502320}, shortjournal = {Adv. Sci.}, title = {Squaraine dyes for organic photomultiplication photodetectors with 220% external quantum efficiency at 1240 nm}, volume = {12}, year = {2025}, }
• (2025). Kinsenoside-loaded microneedle accelerates diabetic wound healing by reprogramming macrophage metabolism via inhibiting IRE1α/XBP1 signaling axis. ADVS, 12(26), 2502293. (www)

  @article{ , abstract = {Continuously bacterial infection, undue oxidative stress, and inflammatory responses in the skin tissue microenvironment determine the delayed healing outcome of diabetic wounds, which remain a tough clinical challenge and need multifaceted therapeutic strategies. In this work, HA-ADH/HA-QA-ALD-based hydrogel microneedle (HAQA-MN) with antimicrobial and antioxidative activities incorporating kinsenoside (KD) coated with macrophage membrane (M-KD) targeting inflammation relief is developed to improve the cutaneous micro-niche. KD is observed to trigger trimethylamine N-oxide-irritated proinflammatory macrophages repolarization from M1 state to anti-inflammatory M2 phenotype, and the underlying mechanism is due to drug-induced IRE1α/XBP1/HIF-1α pathway suppression, accompanied by diminution of glycolysis and enhancement of oxidative phosphorylation, resulting in proinflammatory cascade inhibition and anti-inflammatory signaling enhancement. The hydrazone cross-linked HAQA-MN possesses favorable biocompatibility, self-healing, controlled release of M-KD and excellent mechanical properties. Moreover, the MN patch remarkedly restrains the survival of E. coli and S. aureus and eliminates hydrogen peroxide to preserve cellular viability. Notably, M-KD@HAQA-MN array effectively ameliorates cutaneous inflammation and oxidative stress and facilitate angiogenesis and collagen deposition, thereby accelerating tissue regeneration of diabetic mice with a full-thickness skin defect model. Collectively, this study highlights a multifunctional MN platform as a promising candidate in clinical application for the treatment of diabetic wounds.}, archive = {J_ADVS}, author = {Li Lu and Jiewen Liao and Chao Xu and Yuan Xiong and Juan Zhou and Guangji Wang and Ze Lin and Kangkang Zha and Chuanlu Lin and Ruiyin Zeng and Guandong Dai and Qian Feng and Bobin Mi and Guohui Liu}, doi = {10.1002/advs.202502293}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502293}, shortjournal = {Adv. Sci.}, title = {Kinsenoside-loaded microneedle accelerates diabetic wound healing by reprogramming macrophage metabolism via inhibiting IRE1α/XBP1 signaling axis}, volume = {12}, year = {2025}, }
• (2025). Implementing multimodal hardware security with 2D α-In2Se3 ferroelectric transistor. ADVS, 12(26), 2502286. (www)

  @article{ , abstract = {Security is a critical challenge in the integrated circuit (IC) industry, yet device-level hardware security remains largely underexplored. Most existing solutions necessitate modifications to current technology nodes and typically address only a single security threat, leaving them vulnerable to diverse attacks while incurring substantial costs in area, energy, and resources. In this study, an out-of-the-box security solution is proposed that integrates an in-memory sensing and computing (IMSC) architecture based on α-In 2 Se 3 transistor, specifically designed for versatile and multimodal secure applications. By leveraging the unique ferroelectric, optoelectronic, and semiconducting properties of α-In 2 Se 3 , the study demonstrates the secure transistor's electronic and optoelectronic synaptic behaviors, along with its capability for reconfigurable logic operations. Based on these, the secure transistor successfully implements four key security primitives: anticounterfeiting, watermarking, logic locking, and IC camouflaging in a single-transistor structure, offering robust protection against counterfeit ICs, intellectual property theft, and reverse engineering. The multimodal secure transistor demonstrates the functional flexibility in addressing various security threats.}, archive = {J_ADVS}, author = {Xinwei Zhang and Jiachao Zhou and Yishu Zhang and Jian Chai and Yongqing Bai and Hailiang Wang and Qian He and Xi Wang and Lin Wang and Yuda Zhao and Yang Xu and Bin Yu}, doi = {10.1002/advs.202502286}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502286}, shortjournal = {Adv. Sci.}, title = {Implementing multimodal hardware security with 2D α-In2Se3 ferroelectric transistor}, volume = {12}, year = {2025}, }
• (2025). Two-step tandem catalysis for high-efficiency ammonia synthesis via nitrate reduction on anion-intercalated CoNi LDH and Cu/Cu2O. ADVS, 12(26), 2502262. (www)

  @article{ , abstract = {Ammonia is essential across industry, agriculture, and as a future carbon-free energy carrier. Electrocatalytic nitrate reduction (NitRR) offers a sustainable path for removing nitrate contaminants from wastewater and groundwater while using abundant nitrate ions as nitrogen sources under eco-friendly conditions. However, the NitRR pathway, which involves sequential reactions, poses challenges in synchronizing the rate of nitrate-to-nitrite conversion with the subsequent reduction of nitrite to ammonia, particularly as the initial reduction step is rate-limiting. This study presents a CoNi layered double hydroxide (LDH) approach to finely control hydrogen radical (*H) supply, paired with Cu/Cu 2 O redox coupling, to achieve optimal rate matching. CoNi LDH is engineered with various anion intercalations (NO 3 − , Cl − , SO 4 2− , MoO 4 2− , WO 4 2− ) to regulate *H capacity. By integrating Cu/Cu 2 O and CoNi LDH, tandem kinetic descriptors, including a volcano curve, are employed to predict rate constants, facilitating ideal kinetic matching for efficient ammonia synthesis. The optimized MoO 4 -CoNi LDH/CuO NW/CF electrode demonstrated exceptional performance, achieving a 99.78% Faraday efficiency, a yield of 1.12 mmol cm −2 h −1 at −0.2 V vs. RHE, and robust 14-h stability. The model descriptors effectively elucidated the kinetic pathway, linking reaction rates and factors impacting ammonia production.}, archive = {J_ADVS}, author = {Changzheng Lin and Weijia Li and Hao Chen and Jiangtao Feng and Mengyuan Zhu and Jinwen Shi and Mingtao Li and Bo Hou and Zhenyu Wang and Xin Chen and Jia Liu and Wei Yan}, doi = {10.1002/advs.202502262}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502262}, shortjournal = {Adv. Sci.}, title = {Two-step tandem catalysis for high-efficiency ammonia synthesis via nitrate reduction on anion-intercalated CoNi LDH and Cu/Cu2O}, volume = {12}, year = {2025}, }
• (2025). Cryo-exfoliation synthesis of borophene and its application in wearable electronics. ADVS, 12(26), 2502257. (www)

  @article{ , abstract = {Borophene, an anisotropic Dirac Xene, exhibits diverse crystallographic phases, including metallic β₁₂, χ₃, and semiconducting α phases, alongside exceptional properties such as high electronic mobility, superior Young's modulus, thermal conductivity, superconductivity, and ferroelasticity. These attributes position borophene as a promising material for energy storage, electrocatalysis, and wearable electronics. However, its widespread application is hindered by existing synthesis methods that are expensive, complex, and yield-limited. This study presents a novel, cost-effective, environmentally friendly cryo-exfoliation method for borophene synthesis. Crystalline boron powder is rapidly quenched in liquid nitrogen and subjected to mild sonication, producing borophene with lateral dimensions of ≈50 to 10 µm and few-layer thicknesses. Advanced characterizations, including Atomic Force Microscopy (AFM), High-Resolution Transmission Electron Microscopy (HRTEM), Raman Spectroscopy, and X-ray Photoelectron Spectroscopy (XPS), confirm structural integrity, chemical purity, and minimal surface oxidation. Molecular dynamics simulations further elucidate the weakened inter-layer coupling induced by cryo-processing. The integration of borophene into Polyvinylidene Fluoride (PVDF) nanocomposites demonstrates its potential for wearable electronics, achieving motion-sensitive devices with outstanding performance, generating output voltages up to ≈40 V. This scalable cryo-exfoliation approach paves the way for borophene-based applications in energy harvesting, sensing, and next-generation electronics.}, archive = {J_ADVS}, author = {Zhixuan Li and Gaurav Pandey and Arkamita Bandyopadhyay and Kamlendra Awasthi and John V. Kennedy and Prashant Kumar and Ajayan Vinu}, doi = {10.1002/advs.202502257}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502257}, shortjournal = {Adv. Sci.}, title = {Cryo-exfoliation synthesis of borophene and its application in wearable electronics}, volume = {12}, year = {2025}, }
• (2025). Defect-engineered multi-intermetallic heterostructures as multisite electrocatalysts for efficient water splitting. ADVS, 12(26), 2502244. (www)

  @article{ , abstract = {Efficient water splitting for renewable hydrogen production requires the development of highly active and stable electrocatalysts. This study investigates the design and synthesis of defect-engineered multimetallic heterostructures as advanced electrocatalysts for overall water splitting. A synergistic approach combining atomic-scale defect engineering and multiphase heterostructures is employed to enhance catalytic activity. A series of highly porous intermetallic alloys (CoCuMoNi) with abundant defect sites are synthesized using a high-temperature alloying-dealloying technique. Due to the synergistic effect of multiphase interfaces, built-in electric fields, and defect engineering, the CoCuMoNi catalyst exhibits excellent bifunctional activity for water splitting (Hydrogen evolution reaction: 14 mV@10 mA cm −2 ; Oxygen evolution reaction (OER): 211 mV@10 mA cm −2 ; Overall water splitting: 1.559 V@100 mA cm −2 ), with significantly enhanced activity compared to pure metals and conventional materials. Additionally, these structures demonstrate excellent stability and durability. Advanced characterization techniques and density functional theory (DFT) reveal that the formation of defect sites and heterojunctions not only induces electronic modulation but also enhances intermetallic interactions and charge transfer from Ni and Mo to Cu and Co, facilitating intermediate formation and transformation, thereby boosting intrinsic activity. This work highlights the potential of defect-engineered multimetallic heterostructures as scalable and efficient electrocatalytic platforms, paving the way for their practical applications in clean energy technologies.}, archive = {J_ADVS}, author = {Xiang-Feng Wu and Zi-Yan Li and Hui Wang and Jun-Chuan Wang and Guo-Qiang Xi and Xiao-Jin Zhao and Chen-Xu Zhang and Wu-Gang Liao and Johnny C. Ho}, doi = {10.1002/advs.202502244}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502244}, shortjournal = {Adv. Sci.}, title = {Defect-engineered multi-intermetallic heterostructures as multisite electrocatalysts for efficient water splitting}, volume = {12}, year = {2025}, }
• (2025). Enhanced reaction kinetics in sodium-ion batteries achieved by 3D heterostructure CoS2/CoS with self-induced internal electric field. ADVS, 12(26), 2502241. (www)

  @article{ , abstract = {The sluggish charging and restricted mass transfer of cobalt-based sulfides have provoked in cycling stability, poor rate, and low initial coulombic efficiency, impeding their practical application. Developing electronic configurations and heterostructures are effective methods to improve conductivity and accelerate mass transfer. In this work, heterostructured carbon/cobalt sulfides embedded in honeycomb-like nitrogen-doped carbon (HC@CoS 2 /CoS/NC) were proposed as a cost-effective strategy. These composites feature interconnected channels, facilitating rapid electron transport and efficient electrolyte diffusion. This self-induced internal electric field design of HC@CoS₂/CoS/NC enhanced the charge movement, inherent conductivity and optimized the electrochemical kinetics as anode materials. Theoretical calculations indicate that the development of heterostructures with self-induced internal electric fields is crucial for improving the charge particle/electron movement during the charge–discharge cycles of sodium-ion batteries (SIBs), leading to enhanced Na + diffusion. This anode demonstrated a high specific capacity of 809.0 mAh g −1 at 0.1 A g −1 , retaining a capacity of 465.2 mAh g −1 after 700 cycles at 15 A g −1 . When paired with Na 3 V 2 (PO 4 ) 3 , the full-cell maintained a specific capacity of 108.9 mAh g −1 after 200 cycles at 1.0 A g −1 . This research presents an effective approach for developing transitional metal sulfide heterostructures as high-performance anode materials for SIBs.}, archive = {J_ADVS}, author = {Jin Liang and Jiawen Sun and Xin Cao and Xiaoshan Li and Xiaoyi Chen and Ruizhe Xing and Jie Kong}, doi = {10.1002/advs.202502241}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502241}, shortjournal = {Adv. Sci.}, title = {Enhanced reaction kinetics in sodium-ion batteries achieved by 3D heterostructure CoS2/CoS with self-induced internal electric field}, volume = {12}, year = {2025}, }
• (2025). Vibration-induced stabilization of lithium anodes: Synergistic effects of morphological and SEI evolution. ADVS, 12(26), 2502192. (www)

  @article{ , abstract = {Lithium metal is a highly attractive anode material for next-generation energy storage systems due to its extremely high energy density and low redox potential. Despite the growing interest in lithium metal batteries for electric vehicles (EVs), the effect of mechanical vibrations—a common condition in automotive environments—on lithium metal anodes has rarely received attention. In this study, the impact of linear shear vibration on Li metal anodes is investigated and the resulting electrochemical behavior is analyzed. Cells exposed to horizontal vibration exhibited a thinner Li electrodeposition layer compared to non-vibrated cells (7.18 µm vs 11.3 µm). This vibration-induced effect also delayed the increase in overpotential in Li||Li symmetric cells, extending their cycling life by up to 30%. Moreover, full cell comprising Li metal and LiFePO 4 demonstrated enhanced stability under horizontal vibration. Physicochemical and electrochemical analyses revealed that the Li 2 O-rich solid electrolyte interphase (SEI) formed on the electrode surface, leading to densely packed Li deposits and improved cycling performance. These findings present a novel strategy to enhance the electrochemical performance of Li electrodes through the application of linear vibration, offering valuable insights for designing EV batteries.}, archive = {J_ADVS}, author = {Taeksoo Jung and Sunghyun Jie and Huiyeol Lee and Jinwook Jung and Joonhee Kang and Seunghun Baek and Byeongyong Lee}, doi = {10.1002/advs.202502192}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502192}, shortjournal = {Adv. Sci.}, title = {Vibration-induced stabilization of lithium anodes: Synergistic effects of morphological and SEI evolution}, volume = {12}, year = {2025}, }
• (2025). Cardiac slc25a49-mediated energy reprogramming governs doxorubicin-induced cardiomyopathy through the G6P–AP-1–Sln axis. ADVS, 12(26), 2502163. (www)

  @article{ , abstract = {Doxorubicin (Dox), a potent antitumor drug, is linked to cardiac toxicity. Few mechanism-based therapies against cardiotoxicity are available. Dysfunction in mitochondrial energy metabolism contributes to Dox-induced cardiomyopathy. It is aimed at exploring the association between specific mechanism of energy reprogramming and Dox-induced cardiomyopathy. Cardiac-specific ablation of Slc25a49 mice are generated by crossing Slc25a49 flox/flox mice with Myh6-Cre mice. Slc25a49 HKO mice or SLC25A49 KD cardiomyocytes is treated with Dox. Echocardiography, histological analysis, transmission electron microscopy, bulk RNA sequencing, cell bioenergetic profiling, metabolomics test, chromatin immunoprecipitation, and dual-luciferase reporter assay are conducted to delineate the phenotype and elucidate the molecular mechanisms. Specific ablation of Slc25a49 in cardiomyocytes leads to exacerbated Dox-induced cardiomyopathy, characterized by compromised mitochondrial respiration enhanced glycolysis and increased glycolytic metabolite glucose-6-phosphate (G6P) levels, subsequently activating the activator protein-1 (AP-1) complex. The stimulation of the G6P–AP-1 axis intensifies myocardial damage via transcriptionally regulating Sarcolipin (Sln) expression. Strikingly, targeting of this axis with the AP-1 inhibitor T-5224 effectively improves survival and enhances cardiac function in Dox-induced cardiomyopathy. This study provides mechanistic insights into energy reprogramming that permits myocardial dysfunction, and thus provides a proof of concept for antienergy reprogramming therapy for Dox-induced cardiomyopathy through directly modulating G6P–AP-1–Sln axis.}, archive = {J_ADVS}, author = {Sitong Wan and Jingyi Qi and Yi Xia and Chang Fan and Teng Xu and Xu Zhang and Jiaxin Shi and Chenxuan Wang and Yitong Cheng and Dongyuan Zhang and Rong Liu and Yinhua Zhu and Changchang Cao and Dekui Jin and Peng An and Yongting Luo and Junjie Luo}, doi = {10.1002/advs.202502163}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502163}, shortjournal = {Adv. Sci.}, title = {Cardiac slc25a49-mediated energy reprogramming governs doxorubicin-induced cardiomyopathy through the G6P–AP-1–Sln axis}, volume = {12}, year = {2025}, }
• (2025). A touch enabled hemodynamic and metabolic monitor. ADVS, 12(26), 2502138. (www)

  @article{ , abstract = {Accurate health analysis demands real-time tracking of multiple biomarkers and vital signs under dynamic physiological conditions. Current multimodal hybrid platforms provide biochemical and biophysical data but are limited by active sweat collection for biochemical sensing and bulky designs for biophysical sensing. Here a touch-enabled platform is presented that simultaneously monitors vitals and metabolic markers. With a simple tri-finger touch, the platform measures mean arterial pressure and heart rate using photoplethysmography, and glucose, uric acid, and cortisol at rest by leveraging the natural perspiration at the fingertip. Extended studies involving diverse activities reveal strong dynamic interplay among the metabolic and vital profiles, with mean arterial pressure showing the highest sensitivity to cortisol fluctuations. The platform delivers comprehensive health information linking diet, lifestyle, metabolism, and serves as an early metabolic or hormonal stress indicator. Valuable insights gained through the platform position it as a promising tool for personalized health and wellness management.}, archive = {J_ADVS}, author = {Omeed Djassemi and Tamoghna Saha and Ponnusamy Nandhakumar and Muhammad Inam Khan and Hannah Fishman and Sara Earney and Chochanon Moonla and Yuchen Xu and Henry Thai and Sofia Morales-Fermin and Gyeongho Kim and Rhea Park and Beya Acot and Oscar Wu and Cannon Wurster and An-Yi Chang and Christopher Cheung and Julia Silberman and Shichao Ding and Joseph Wang}, doi = {10.1002/advs.202502138}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502138}, shortjournal = {Adv. Sci.}, title = {A touch enabled hemodynamic and metabolic monitor}, volume = {12}, year = {2025}, }
• (2025). CCDC80 protects against aortic dissection and rupture by maintaining the contractile smooth muscle cell phenotype. ADVS, 12(26), 2502108. (www)

  @article{ , abstract = {Aortic dissection (AD) is a life-threatening medical emergency characterized by adverse vascular remodeling. Coiled-coil domain-containing protein 80 (CCDC80) plays an essential role in regulating cardiovascular remodeling. This study aims to define the role of CCDC80 in the formation and development of AD. Significant downregulation of CCDC80 in vascular smooth muscle cell (VSMC) in human and mouse AD is identified. Then, CCDC80 knockout mice (CCDC80 −/− ) and VSMC-specific CCDC80 knockout mice (CCDC80 fl/fl SM22α Cre + ) treated with angiotensin II (Ang II) or Ang II combined with β-aminopropionitrile monofumarate (BAPN) frequently develop AD with higher frequency and severity, accompanied by severe elastin fragmentation and collagen deposition. Mechanistically, CCDC80 interacts with JAK2, and CCDC80 deficiency promotes VSMC phenotype switching, proliferation, and migration as well as matrix metalloproteinase production by activating the JAK2/STAT3 signaling pathway. Moreover, the JAK2/STAT3 pathway-specific inhibitor ameliorates adverse vascular remodeling and reduces AD formation in CCDC80-knockout mice by mitigating VSMC phenotype switching. In conclusion, CCDC80 deficiency exacerbates the progression of events leading to AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs. These findings highlight that CCDC80 is a potential key target for the prevention and treatment of AD.}, archive = {J_ADVS}, author = {Qingqing Xiao and Yi Li and Bin Cai and Xiying Huang and Liang Fang and Feng Liang and Long Chen and Ke Xu and Weifeng Zhang and Xiaolei Wang and Anwen Yin and Xia Wang and Zhaohua Cai and Fei Zhuang and Qin Shao and Bin Zhou and Berthold Hocher and Ben He and Linghong Shen}, doi = {10.1002/advs.202502108}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502108}, shortjournal = {Adv. Sci.}, title = {CCDC80 protects against aortic dissection and rupture by maintaining the contractile smooth muscle cell phenotype}, volume = {12}, year = {2025}, }
• (2025). Elasticity-driven nanomechanical interaction to improve the targeting ability of lipid nanoparticles in the malignant tumor microenvironment. ADVS, 12(26), 2502073. (www)

  @article{ , abstract = {The mechanical elasticity of lipid nanoparticles (LNPs) is crucial to their pharmaceutical performance. This study investigates how the mechanical interactions between LNPs, target cells, and macrophages affect the internalization of LNPs into target cells at tumor sites. According to our bio-mechanical study, drug-resistant breast cancer cells are stiffer than sensitive ones, while invasive cells are softer; similarly, protumoral M2 macrophages are softer than M1 macrophages. Softer LNPs show increased cellular uptake in breast cancer cells and macrophages, with enhanced engulfment in invasive cells and M2 macrophages. Additionally, the presence of M2 macrophages promotes greater LNP internalization by cancer cells, facilitating the malignant and invasive nature of cancer cells. In addition, because breast cancer cells engulf LNPs via an energy-efficient fusion pathway but LNPs in macrophages undergo clathrin-mediated endocytosis, LNPs are internalized more into cancer cells but not into M2. In orthotopic tumor models, softer LNPs penetrate tumors quickly, enhancing suppression, whereas stiffer LNPs permeate slowly but show prolonged retention in stiffer tumors, supporting antitumor efficacy with repeated dosing. These findings underscore the importance of mechanical interactions between LNPs, target cells, and macrophages in optimizing LNP delivery systems, offering insights for more effective designs.}, archive = {J_ADVS}, author = {Eunhee Lee and Loi Nguyen Dang and Jinsol Choi and Haesoo Kim and Lyndon Bastatas and Soyeun Park}, doi = {10.1002/advs.202502073}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502073}, shortjournal = {Adv. Sci.}, title = {Elasticity-driven nanomechanical interaction to improve the targeting ability of lipid nanoparticles in the malignant tumor microenvironment}, volume = {12}, year = {2025}, }
• (2025). Genetic regulation of alternative polyadenylation provides novel insights into molecular mechanisms underlying non-small cell lung cancer. ADVS, 12(26), 2502008. (www)

  @article{ , abstract = {Emerging evidence emphasizes the critical role of alternative polyadenylation (APA) in posttranscriptional regulation of genes, and APA-associated genetic variants (apaQTLs) show particular relevance for multiple disease. However, genetic regulation of APA and its role in non-small cell lung cancer (NSCLC) risk have not been thoroughly studied. Here, by leveraging genotype and APA data from The Cancer Genome Atlas, the association between genetic variation and APA is determined in NSCLC samples. The identified apaQTLs are distinct from eQTLs and are preferentially enriched in functionally relevant characteristics, including poly(A) motifs, APA-associated RBP binding sites, functional elements, and known NSCLC risk loci. Moreover, genes associated with apaQTLs are broadly involved in cancer-related biological process. Of note, integration of apaQTL variants with traditional GWAS-derived PRS is proved as a potential screening tool for NSCLC. By integrating large-scale population and biological experiments, a functional apaQTL variant rs9606 in LYRM4 is identified. Mechanistically, rs9606 induces aberrant APA process of LYRM4 via allele-specific interacting with NUDT21, which lead to increased expression of oncogene LYRM4 and thus contribute to NSCLC risk. This study demonstrates the distinct contribution of APA-associated genetic variants in NSCLC risk, providing critical clues and potential targets for NSCLC etiology and clinical intervention.}, archive = {J_ADVS}, author = {Meng Jin and Yongbiao Huang and Bin Li and Yuan Wang and Yan Li and Zhirui Chen and Zhe Tang and Chaofan Liu and Lei Zhang and Xianglin Yuan and Jianbo Tian and Bo Liu}, doi = {10.1002/advs.202502008}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502008}, shortjournal = {Adv. Sci.}, title = {Genetic regulation of alternative polyadenylation provides novel insights into molecular mechanisms underlying non-small cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). Reductive supramolecular in situ construction of nano-platinum effectively couples cathodic hydrogen evolution and anodic alcohol oxidation. ADVS, 12(26), 2502002. (www)

  @article{ , abstract = {The deployment of high-performance catalysts and the acceleration of anodic reaction kinetics are key measures to achieve maximum energy efficiency in overall water electrolysis hydrogen production systems. Here, an innovative strategy is developed by directly constructing a supramolecular framework embedded with boron clusters and cucurbituril as reducing agent. This approach enabled the in situ conversion of Pt⁴⁺ into highly dispersed, small-sized nano-platinum, which are subsequently distributed on a boron-carbon-nitrogen (BCN) matrix. The resulting Pt/BNHCSs catalyst demonstrates the ability to facilitate electrocatalytic water splitting for hydrogen production across multiple scenarios while simultaneously accelerating the anodic methanol oxidation kinetics, significantly outperforming commercial Pt/C catalyst in various aspects. The cathodic hydrogen evolution-anodic methanol oxidation coupling system constructed using the Pt/BNHCSs greatly reduces the overall energy consumption of the electrolysis system. In situ attenuated total reflection Fourier transform infrared and online differential electrochemical mass spectrometry reveals that the catalyst interface enhances H₂O adsorption and promotes the CH₃OH→CO conversion process, and density functional theory calculations indicated that the BCN support facilitated the evolution of H₂O to H₂ and CH₃OH to CO, elucidating the mechanism by which Pt/BNHCSs simultaneously promoted hydrogen production and methanol oxidation.}, archive = {J_ADVS}, author = {Rui Bai and Qiao Ye and Cuiyu Li and Haijian Wang and Yan Zhao and Yicheng Zhang and Yingtang Zhou and Xue Zhao}, doi = {10.1002/advs.202502002}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2502002}, shortjournal = {Adv. Sci.}, title = {Reductive supramolecular in situ construction of nano-platinum effectively couples cathodic hydrogen evolution and anodic alcohol oxidation}, volume = {12}, year = {2025}, }
• (2025). Colloidal synthesis of sub-1-nm PbSe nanowires via cation exchange for high-performance near-infrared self-powered photoelectrochemical-type photodetectors. ADVS, 12(26), 2501993. (www)

  @article{ , abstract = {Sub-1-nm nanowires (NWs) with fascinating physicochemical properties have demonstrated remarkable potential for applications across various fields. However, it remains a great challenge to prepare sub-1-nm NWs with near-infrared (NIR) absorption characteristics and explore their optoelectronic applications, so far. Herein, a novel cation-exchange strategy in N, N-dimethylformamide (DMF) solvent is introduced to synthesize sub-1-nm PbSe NWs, starting from sub-1-nm ZnSe NWs. Theoretical calculations and nuclear magnetic resonance (NMR) measurements have confirmed that the cation exchange reaction in DMF effectively reduces the barriers for Zn 2+ extraction and Pb 2+ introduction compared to the conventional toluene/methanol system. Notably, the resulting sub-1-nm PbSe NWs exhibit a strong absorption peak at ≈940 nm. Leveraging their unique NIR absorption features and superior carrier transport properties, self-powered photoelectrochemical-type (PEC) photodetectors is fabricated based on sub-1-nm PbSe NWs embedded in polyvinylidene fluoride (PVDF) composite films. These photodetectors demonstrated exceptional photoresponse performance under 940 nm illumination (8.0 mW cm −2 ), with a typical on/off ratio of 4860, a detectivity of 4.65 × 10 11 Jones, and a responsivity of 113 mA W −1 . This work provides a new approach for developing and investigating NIR photoactive sub-1-nm semiconductor NWs with broad application prospects.}, archive = {J_ADVS}, author = {Xiaoli Li and Sizhao Xing and Yanli Li and Guangshuo Wang and Xiaoyi Gao and Dong Li}, doi = {10.1002/advs.202501993}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501993}, shortjournal = {Adv. Sci.}, title = {Colloidal synthesis of sub-1-nm PbSe nanowires via cation exchange for high-performance near-infrared self-powered photoelectrochemical-type photodetectors}, volume = {12}, year = {2025}, }
• (2025). A unique THN motif is critical for enabling efficient C-terminal traceless cleavage. ADVS, 12(26), 2501991. (www)

  @article{ , abstract = {Traceless protein cleavage is a significant challenge in intein application, as most common inteins studied today are not both active and promiscuous. In this study, the intein gp41-1 is engineered, which demonstrates the most efficient traceless cleavage reported to date and shows high compatibility to 1st amino acid. The evidence provided for the first time is that the unique THN motif, which is prevalent in class 3 inteins, is essential for achieving high-efficiency traceless C-terminal cleavage. The hydrogen bond between the hydroxyl group of Thr 123 and the main chain of His 124 is suggested to be indispensable for stabilizing the THN motif to separate Asp 107 (the limiting factor for C-cleavage) from Asn 125 and the C-extein residues from the active sites, which jointly lead to the highest traceless C-cleavage activity. Both cleavage data and molecular dynamics (MD) simulations results demonstrate that mutating Thr 123 greatly disturbed the THN motif, leading to inactivity. These findings reveal a pivotal motif for intein traceless cleavage efficiency, providing valuable insights for designing inteins with enhanced traceless C-terminal cleavage capabilities in future applications.}, archive = {J_ADVS}, author = {Ruocheng Gu and Yunuo Lin and Rouyu Di and Tongtong Zhou and Tingwen Fan and Wei Li and Lili Miao and Huaiyi Yang}, doi = {10.1002/advs.202501991}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501991}, shortjournal = {Adv. Sci.}, title = {A unique THN motif is critical for enabling efficient C-terminal traceless cleavage}, volume = {12}, year = {2025}, }
• (2025). Recycling defunct lithium-ion battery cathodes to quaternary layered double hydroxides for efficient oxygen evolution reaction. ADVS, 12(26), 2501957. (www)

  @article{ , abstract = {With the wide-application of batteries (LIBs) correlated industries, continuous accumulation of wasted LIBs occurs, which causes environment issues and exhaustion of metal resources. Therefore, it is of vital importance to develop practical and efficient techniques to reuse the materials in wasted LIBs. In this work, a novel approach is proposed to reuse scrapped Li(Co 0.8 Ni 0.1 Mn 0.1 )O 2 and LiFePO 4 cathodes by converting them into oxygen evolution reaction (OER) electrocatalysts through simple leaching and co-precipitation steps. The synthesized quaternary layered double hydroxides (Q-LDHs) exhibits excellent OER activity, with the optimized Q-LDH-0.1 requiring a low overpotential of 270 mV to achieve the given current density of 10 mA cm −2 , showing a low Tafel slope of 66 mV dec −1 . The high catalytic activity of Q-LDH-0.1 should be attributed to the synergistic effects of electron interactions among homogeneously distributed iron, nickel, cobalt, and manganese atoms, the highly disordered coordination environment, and the catalytic activity of their mixed valence states, which combine to enhance the adsorption and transformation of OER intermediates. Additionally, the involvement of the more favorable lattice oxygen mechanism further promotes OER efficiency. This work presents a feasible approach for recycling abandoned LIB cathodic materials and offers valuable insights for developing low-cost, highly-effective LDH electrocatalysts.}, archive = {J_ADVS}, author = {Ronghou Yao and Jin Wu and Shivam Kansara and Zhaowei Sun and Hyokyeong Kang and Feng Liu and Kaizhao Wang and Jin Hu and Xiangming Li and Dapeng Wu and Jang-Yeon Hwang and Shizhao Xiong}, doi = {10.1002/advs.202501957}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501957}, shortjournal = {Adv. Sci.}, title = {Recycling defunct lithium-ion battery cathodes to quaternary layered double hydroxides for efficient oxygen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). Utilizing photothermal effect enhances photocatalytic water splitting coupled with selective benzyl alcohol oxidation over schottky junctions. ADVS, 12(26), 2501931. (www)

  @article{ , abstract = {As is well known, there are problems such as low utilization rate of photogenerated holes and resource consumption of sacrificial agent in solar-driven photocatalytic water splitting to hydrogen technology. Herein, WC quantum dots decorated defective ZnIn 2 S 4 nanosheets (DZIS/WCQDs) dual-functional photocatalysts are fabricated. Its unique Schottky junctions and photothermal effect significantly promote the separation and transport efficiency of photogenerated carriers, as well as achieving synergistic enhancement of photocatalytic water splitting coupled with selective oxidation of benzyl alcohol (BA). Moreover, the photothermal effect can slowly induce the decomposition of H 2 O 2 to produce ·OH, and the low concentration ·OH and photogenerated holes continuously generated in situ can directly and rapidly attack the αC─H bond of BA to improve benzaldehyde (BAD) conversion rate and selectivity. Consequently, DZIS/WCQDs composites exhibit a surprising conversion rate and selectivity of 85.34% and 96.53% for BAD, and outstanding H 2 and BAD evolution rates of 12.58 and 10.53 mmol g −1 h −1 without sacrificial agent and co-catalyst. Notably, combining the production rate and selectivity of products, the DZIS/WCQDs is the optimal catalyst material at present. This work opens up a green and carbon free effective path to solve the problems of low efficiency and high cost of photocatalytic hydrogen production.}, archive = {J_ADVS}, author = {Bojing Sun and Mengjia Ye and Yachao Xu and Ying Jiang and Dongfang Hou and Xiu-qing Qiao and Meidi Wang and Yunchen Du and Dong-Sheng Li}, doi = {10.1002/advs.202501931}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501931}, shortjournal = {Adv. Sci.}, title = {Utilizing photothermal effect enhances photocatalytic water splitting coupled with selective benzyl alcohol oxidation over schottky junctions}, volume = {12}, year = {2025}, }
• (2025). The molecular basis of amino acids sensing. ADVS, 12(26), 2501889. (www)

  @article{ , abstract = {Amino acids are organic compounds that serve as the building blocks of proteins and peptides. Additionally, they function as bioactive molecules that play important roles in metabolic regulation and signal transduction. The ability of cells to sense fluctuations in intracellular and extracellular amino acid levels is vital for effectively regulating protein synthesis and catabolism, maintaining homeostasis, adapting to diverse nutritional environments and influencing cell fate decision. In this review, the recent molecular insights into amino acids sensing are discussed, along with the different sensing mechanisms in distinct organisms.}, archive = {J_ADVS}, author = {Cong Jiang and Xiao Tan and Jiali Jin and Ping Wang}, doi = {10.1002/advs.202501889}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501889}, shortjournal = {Adv. Sci.}, title = {The molecular basis of amino acids sensing}, volume = {12}, year = {2025}, }
• (2025). Ambipolar charge transport in perovskite CsPbBr3 γ-ray detectors with superior uniformity and spectral resolution by zone refining processing. ADVS, 12(26), 2501875. (www)

  @article{ , abstract = {Perovskite semiconductor cesium lead bromide (CsPbBr 3 ) has demonstrated great promise as a new-generation gamma-ray detector. However, substantial challenges still present in reproducibly achieving optimal spectroscopic performance. The specific strategy for producing spectroscopic-grade CsPbBr 3 crystals with high reproducibility and uniformity are still not clarified. Herein, efficient zone refining processing is developed for CsPbBr 3 crystals that facilitates impurity segregation to achieve an ultrahigh purity level of ≈1.42 ppm, therefore lowers trap density and balances charge transport. In a typical 30 mm diameter zone-refined CsPbBr 3 ingot, all wafers exhibited remarkable energy resolutions of 6–12% and 3–8% for 241 Am and 57 Co γ-rays under comparable electric fields. The crystals also exhibited an ambipolar charge transport characteristic, resemble to elemental semiconductors, with equivalent hole and electron mobility-lifetime products averaging 5.42 × 10 −3 and 2.27 × 10 −3 cm 2 ∙V −1 , respectively. Consequently, over 95% of wafers achieved energy resolutions below 5% whereas 70% exceeded 3% for 137 Cs γ-rays, demonstrating exceptional reproducibility and uniformity. Notably, a champion energy resolution of 1.3% with an outstanding photopeak-to-Compton (P/C) ratio of ≈5.3 is attained in an ambipolar planar detector. It is anticipated that this work shall expedite scalable manufacturing and practical applications of CsPbBr 3 detectors.}, archive = {J_ADVS}, author = {Bao Xiao and Yuquan Wang and Ning Ding and Haoming Qin and Nannan Shen and Xuchang He and Qihao Sun and Yihui He}, doi = {10.1002/advs.202501875}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501875}, shortjournal = {Adv. Sci.}, title = {Ambipolar charge transport in perovskite CsPbBr3 γ-ray detectors with superior uniformity and spectral resolution by zone refining processing}, volume = {12}, year = {2025}, }
• (2025). Transition metal slab gliding: One key process for activating anionic redox reaction in p2-type transition metal oxide cathodes. ADVS, 12(26), 2501852. (www)

  @article{ , abstract = {Anionic redox chemistry is crucial for determining the capacity and stability of layered oxide cathodes for Na-ion batteries. However, the driving forces of anionic redox remain elusive. Na–O–A (A = alkali metal, alkaline earth metal, or vacancy) configurations have been identified as key to activating anionic redox reactions in transition metal (TM)-deficient oxide materials. However, reversible oxygen redox reactions are also observed in TM-stoichiometric oxide materials, although the Na–O–A configurations cannot be established in these systems. A TM-stoichiometric P2-type Na 2/3 Cu 1/3 Mn 2/3 O 2 cathode and its Ti 4+ -substituted analogue (Na 2/3 Cu 1/3 Mn 1/2 Ti 1/6 O 2 ) are herein studied for deciphering the underlying mechanism. The incorporation of Ti 4+ disrupts the ordered arrangement of TM layers, accelerates TM slab gliding, and facilitates TM migration, thus affording new Na–O–vacancy configurations and activating the reversible oxygen redox reaction. Consequently, Na 2/3 Cu 1/3 Mn 1/2 Ti 1/6 O 2 exhibits an initial discharge capacity of 153 mAh g −1 and a capacity retention of 80% after 300 cycles at 2 C rate. This work provides plausible routes for reversible anionic redox reactions and increasing the energy density of SIBs.}, archive = {J_ADVS}, author = {Dongxiao Wang and Feihu Zou and Weiguang Lin and Xiaochen Zhang and Xinran Zhang and Xingguo Qi and Shuyin Xu and Huican Mao and Dongdong Xiao and Shigang Lu and Bingkun Guo and Yong-Sheng Hu and Yingchun Lyu}, doi = {10.1002/advs.202501852}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501852}, shortjournal = {Adv. Sci.}, title = {Transition metal slab gliding: One key process for activating anionic redox reaction in p2-type transition metal oxide cathodes}, volume = {12}, year = {2025}, }
• (2025). Laser-induced co-doped FePS3 with massively phosphorus sulfur vacancies nanosheet for efficient and highly stable electrocatalytic oxygen reaction. ADVS, 12(26), 2501836. (www)

  @article{ , abstract = {Purposely optimizing material structure to reduce the energy change of the rate-determining step (RDS) for promoting oxygen evolution reaction (OER) catalytic performance is a major strategy to enhance the energy efficiency of electrocatalytic water splitting. Density functional theory (DFT) simulations indicate that creating a large number of defects on or inside the 2D FePS 3 is very beneficial for its catalytic reaction of OER, especially when there are more defects, the structural diversity of the surface is more conducive to the adsorption and reaction of intermediates. In particular, when Co-doped FePS 3 surfaces produce a large number of S and P defects and expose metallic Fe as active sites, its catalytic performance, especially the catalytic stability, is significantly enhanced. A facile and efficient laser-ablation-in-liquid method is then designed to combine Co with 2D layered crystal FePS 3 . Amazingly, the laser-induced (Fe 0.53 Co 0.46 )PS 3 sample exhibits excellent OER performance, with an overpotential at 288 mV and a small Tafel slope of 58.3 mV dec −1 . Moreover, (Fe 0.53 Co 0.46 )PS 3 operates stably for 138 h at 10 mA cm −2 and 27 h at 100 mA cm −2 , which shows that the stability of (Fe 0.53 Co 0.46 )PS 3 far exceeds that of most of OER catalysts of Fe─Co system so far, and the comprehensive OER performance is in the first echelon of transition metal catalyst systems. This work proposes an in-depth understanding of the structural mechanism design of massive phosphorus sulfur vacancies by laser-induced manufacturing and will shed new light on promoting the stability of transition metal-based OER catalysts without any precious alternatives.}, archive = {J_ADVS}, author = {Ruiqi Xu and Guoshuai Fu and Weimi Ding and Yifan Li and Guowei Yang and Peng Yu and Shuang Li and Pu Liu}, doi = {10.1002/advs.202501836}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501836}, shortjournal = {Adv. Sci.}, title = {Laser-induced co-doped FePS3 with massively phosphorus sulfur vacancies nanosheet for efficient and highly stable electrocatalytic oxygen reaction}, volume = {12}, year = {2025}, }
• (2025). Advanced temperature design for dynamic performance enhancement of PEMFCs under high current density (HCD). ADVS, 12(26), 2501825. (www)

  @article{ , abstract = {The dynamic performance of proton exchange membrane fuel cells (PEMFCs) under high current density (HCD) rapid loading is crucial for commercialization. This study introduces an advanced temperature difference (TD) design featuring an in-plane temperature gradient. By reconstructing cooling channels, optimal temperature distribution across the upstream, midstream, and downstream regions achieves balanced water-gas-heat conditions, enhancing the dynamic response of PEMFCs under HCD loading. Various TD designs are investigated across a broad humidity range, innovatively focusing on key moments involving load initiation, transient voltage minimum (TVM), and steady-state voltage (SSV). Comprehensive evaluations encompassing voltage response and energy consumption assess TD enhancements, while electrochemical impedance spectroscopy (EIS) and local current density monitoring further elucidate underlying mechanisms. Results show the positive temperature difference (PTD) design enhances hydration upstream and mitigates flooding downstream under low-humidity conditions. Conversely, the negative temperature difference (NTD) design tends to dehydration upstream and flooding downstream. At RH = 35%, the PTD design increases TVM by 18.2%, decreases voltage undershoot (VU) by 12.5%, raises SSV by 5.67%, and enhances electricity output by 7%. As humidity increases, the positive effect of the PTD design gradually weakens, though it still benefits the current density distribution uniformity.}, archive = {J_ADVS}, author = {Fengyang Cai and Shanshan Cai and Zhengkai Tu and Siew Hwa Chan}, doi = {10.1002/advs.202501825}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501825}, shortjournal = {Adv. Sci.}, title = {Advanced temperature design for dynamic performance enhancement of PEMFCs under high current density (HCD)}, volume = {12}, year = {2025}, }
• (2025). DON-loaded nanodrug-T cell conjugates with PD-l1 blockade for solid tumor therapy. ADVS, 12(26), 2501815. (www)

  @article{ , abstract = {Adoptive T-cell therapy (ACT) holds significant promise for treating solid tumors but is often constrained by insufficient T-cell infiltration, survival, and functional persistence. To overcome these obstacles, we developed DON-loaded nanodrug-T cell conjugates with PD-L1 blockade, forging a dynamic mutualistic relationship between T cells and therapeutic agents. Sustained release of glutamine antagonist 6-diazo-5-oxo-L-norleucine (DON) within these conjugates continuously enhances T-cell endurance and potency by promoting memory differentiation and elevating crucial adhesion and motility genes. Concurrently, PD-L1 blocking peptides liberate T cells from immunosuppression, assisting T cells with precision toward tumor sites. This dual-targeting strategy—T cells directed at tumor antigens and peptides at PD-L1— enriches the tumor microenvironment with potent therapeutics, amplifying T cell-driven tumor destruction. Our approach effectively overcomes the critical barriers of ACT—infiltration, persistence, and efficacy—unlocking the full therapeutic potential of T-cell therapy against complex solid tumors.}, archive = {J_ADVS}, author = {Xin Yang and Xiaoshuang Niu and Ye Su and Xiaoyun Ye and Wanqiong Li and Wenxuan Zeng and Xin Zhao and Zhuoying He and Qingyu Dong and Xiuman Zhou and Xinghua Sui and Guanyu Chen and Yanfeng Gao and Juan Liu}, doi = {10.1002/advs.202501815}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501815}, shortjournal = {Adv. Sci.}, title = {DON-loaded nanodrug-T cell conjugates with PD-l1 blockade for solid tumor therapy}, volume = {12}, year = {2025}, }
• (2025). Hydrocyclization/Defluorination of CF3-substituted acrylamides: Insights from kinetics of hydrogen atom transfer. ADVS, 12(26), 2501799. (www)

  @article{ , abstract = {The introduction of F-containing groups into organic molecules can significantly alter their physical and chemical properties. Particularly, gem -difluoroalkenes serve as versatile precursors for a broad variety of organofluorine compounds, commonly used in agrochemicals, pharmaceuticals, and materials science. Based on the kinetics of H• transfer to acrylamide ( k H = 2.28 × 10 −4 M −1 s −1 at 300 K in toluene), the study describes a nickel-hydride-(or Li[BEt 3 H]) initiated hydrocyclization/defluorination of CF 3 -substituted acrylamides, offering alternative access to 4-fluorovinyl-substituted 2-pyrrolidones (Seletracetam derivatives that are antiepileptic drug candidates). This process proceeds with high yields and remarkable chemo- and regioselectivity. The hydrocyclization/defluorination can be initiated by either H• or H – transfer, followed by a 5-exo-trig cyclization and subsequent fluorine elimination. The strategy has been applied in the late-stage functionalization of drug molecules, providing a valuable tool in the synthesis of pharmaceutical compounds.}, archive = {J_ADVS}, author = {Yanjun Wan and Ronghui Shao and Jack R. Norton}, doi = {10.1002/advs.202501799}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501799}, shortjournal = {Adv. Sci.}, title = {Hydrocyclization/Defluorination of CF3-substituted acrylamides: Insights from kinetics of hydrogen atom transfer}, volume = {12}, year = {2025}, }
• (2025). Electrochemical functionalization of graphene-on-cu(111): Reactivity, onset potentials, and mechanistic insights. ADVS, 12(26), 2501798. (www)

  @article{ , abstract = {Electrochemical functionalization of graphene facilitates simple and various modifications of graphene properties. However, the scope of the available functional groups and the electrochemical behavior of graphene is not fully understood. The electrochemical reactivity of single crystal and monolayer graphene-on-Cu(111) with various phenyl and alkyl iodides is investigated, and discovered different onset potentials, identifying the extent of the reaction with Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). Differential pulse voltammetry (DPV) and density functional theory (DFT) calculations are employed to elucidate the onset potential differences between the phenyl iodides with different substituents. A comprehensive understanding of graphene's electrochemical reactivity is presented.}, archive = {J_ADVS}, author = {Minhyeok Kim and Yongchul Kim and Geunsik Lee and Rodney S. Ruoff and Sun Hwa Lee}, doi = {10.1002/advs.202501798}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501798}, shortjournal = {Adv. Sci.}, title = {Electrochemical functionalization of graphene-on-cu(111): Reactivity, onset potentials, and mechanistic insights}, volume = {12}, year = {2025}, }
• (2025). Gradient nanostructures and machine learning synergy for robust quantitative surface-enhanced raman scattering. ADVS, 12(26), 2501793. (www)

  @article{ , abstract = {Surface-Enhanced Raman Scattering (SERS) holds significant promise for trace-level molecular detection but faces challenges in achieving reliable quantitative analysis due to signal variability caused by non-uniform “hot spots” and external factors. To address these limitations, a novel SERS platform based on gradient nanostructures is developed using shadow sphere lithography, enabling the acquisition of diverse spectral features from a single analyte concentration under identical conditions. The gradient design minimizes fabrication variability and enhances spectral diversity, while the machine learning (ML) model trained on the multi-spectral dataset significantly outperformed traditional single-spectrum approaches, with the test Mean Squared Error (MSE) reduced by 84.8% and the coefficient of determination ( R 2 ) improved by 61.2%. This strategy captures subtle spectral variations, improving the precision, robustness, and reproducibility of SERS-based quantification, paving the way for its reliable application in real-world scenarios.}, archive = {J_ADVS}, author = {Xiaoyu Zhao and Yuxia Wang and Yuting Liu and Xinyi Chen and Mingyu Cheng and Yaxin Wang and Jiahong Wen and Renxian Gao and Kun Zhang and Fengyi Zhang and Rufei Cui and Yongjun Zhang and Zengyao Wang and Bin Ai}, doi = {10.1002/advs.202501793}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501793}, shortjournal = {Adv. Sci.}, title = {Gradient nanostructures and machine learning synergy for robust quantitative surface-enhanced raman scattering}, volume = {12}, year = {2025}, }
• (2025). Revealing physical mechanisms of spatial pattern formation and switching in ecosystems via nonequilibrium landscape and flux. ADVS, 12(26), 2501776. (www)

  @article{ , abstract = {Spatial patterns are widely observed in numerous nonequilibrium natural systems, often undergoing complex transitions and bifurcations, thereby exhibiting significant importance in many physical and biological systems such as embryonic development, ecosystem desertification, and turbulence. However, how spatial pattern formation emerges and how the spatial pattern switches are not fully understood. Here, a landscape-flux field theory is developed using the spatial mode expansion method to uncover the underlying physical mechanism of the pattern formation and switching. The landscape and flux field are identified as the driving force for spatial dynamics and applied this theory to the critical transitions between spatial vegetation patterns in semi-arid ecosystems, revealing that the nonequilibrium flux drives the switchings of spatial patterns. The emergence of pattern switching is revealed through the optimal pathways and how fast this occurs via the speed of pattern switching. Furthermore, both the averaged flux and the entropy production rate exhibit peaks near pattern switching boundaries, revealing dynamical and thermodynamical origins for pattern transitions, and further offering early warning signals for anticipating spatial pattern switching. This work thus reveals physical mechanisms on spatial pattern-switching in semi-arid ecosystems and, more generally, introduces a useful approach for quantifying spatial pattern switching in nonequilibrium systems, which further offers practical applications such as early warning signals for critical transitions of spatial patterns.}, archive = {J_ADVS}, author = {Jie Su and Wei Wu and Denis D. Patterson and Simon Asher Levin and Jin Wang}, doi = {10.1002/advs.202501776}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501776}, shortjournal = {Adv. Sci.}, title = {Revealing physical mechanisms of spatial pattern formation and switching in ecosystems via nonequilibrium landscape and flux}, volume = {12}, year = {2025}, }
• (2025). Revealing the hazard of mild electrical abuse on the safety characteristics of NaNi1/3Fe1/3Mn1/3O2 cathode sodium-ion battery. ADVS, 12(26), 2501649. (www)

  @article{ , abstract = {This study investigates the degradation of safety characteristics in commercial NaNi 1/3 Fe 1/3 Mn 1/3 O 2 (NFM) sodium-ion batteries (SIBs) under mild electrical abuse, focusing on the impact of a single electrical abuse event on capacity, impedance characteristics, and thermal stability, and reveals the degradation pattern of safety characteristics under long-term electrical abuse cycles. The research finds that while a single mild electrical abuse event has a limited effect on battery capacity, the internal electrochemical properties of the battery still change. Mild overcharge reduces the thermal stability of the anode material, and the increased sodium plating on the anode surface also significantly affects the overall safety characteristics of the battery. In contrast, the harm caused by over-discharge is less severe. After long-term electrical abuse cycles, the battery experiences significant capacity degradation, and prolonged overcharge cycles cause further sodium plating, severely affecting battery safety. Overall, the impact of long-term mild overcharge on safety characteristics is more pronounced. This study not only clarifies the degradation mechanism of sodium-ion battery safety characteristics under electrical abuse but also provides theoretical support for the optimization design and safety evaluation of sodium-ion batteries.}, archive = {J_ADVS}, author = {Qinghua Gui and Bowen Jin and Peng Liu and Kun Yu and Jiarui Zhang and Lei Mao}, doi = {10.1002/advs.202501649}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501649}, shortjournal = {Adv. Sci.}, title = {Revealing the hazard of mild electrical abuse on the safety characteristics of NaNi1/3Fe1/3Mn1/3O2 cathode sodium-ion battery}, volume = {12}, year = {2025}, }
• (2025). Atomic layered ZnO between cu nanoparticles and a PVP polymer layer enable exceptional selectivity and stability in electrocatalytic CO2 reduction to C2H4. ADVS, 12(26), 2501642. (www)

  @article{ , abstract = {This study employs a chemically controlled strategy to construct a few-atomic-layer ZnO structure integrated with polyvinylpyrrolidone (PVP) and nanoscale metallic copper on active carbon. Hydrogen-bond interactions from PVP's N-vinylpyrrolidone allow ZnO to retain a specific proportion of metal atoms, confining electrons at the Cu/ZnO interface to form CuZn nanoalloy clusters. The nanoalloy's dual role in promoting CO adsorption and C─C coupling synergistically boosts C 2 H 4 production during electrochemical CO 2 reduction (ECR). Rapid Cu regeneration further increases adsorbed hydrogen (H ads ) from water splitting, achieving a remarkable C 2 H 4 selectivity of ≈50.2% with stable performance over 10 h. The Zn→Cu electron confinement and interfacial synergy at the organic-oxide-metal heterojunction underscore the catalyst's superior efficiency, offering a promising pathway for sustainable CO 2 -to-C 2 H 4 conversion.}, archive = {J_ADVS}, author = {Lihui Zhou and Hung-Wei Tsai and Ting-Wei Kuo and Jui-Cheng Kao and Yu-Chieh Lo and Ji-Min Chang and Tzu-Hsuan Chiang and Sheng Dai and Kuan-Wen Wang and Tsan-Yao Chen}, doi = {10.1002/advs.202501642}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501642}, shortjournal = {Adv. Sci.}, title = {Atomic layered ZnO between cu nanoparticles and a PVP polymer layer enable exceptional selectivity and stability in electrocatalytic CO2 reduction to C2H4}, volume = {12}, year = {2025}, }
• (2025). Dynamic cap-mediated substrate access and potent inhibitor design of monkeypox virus I7L protease. ADVS, 12(26), 2501625. (www)

  @article{ , abstract = {Monkeypox virus (MPXV), an orthopoxvirus that has long been endemic in Africa, has posed a significant global health threat since 2022. The I7L protease, a highly conserved cysteine proteinase essential for orthopoxvirus replication, represents a promising target for broad-spectrum antiviral drug development. Here, the first crystal structure of MPXV I7L protease is reported, revealing its unique dimeric form and different conformations of a cap region nearby the active site. Molecular dynamics simulations and AlphaFold3 prediction of protease-substrate structures both suggest that this highly flexible cap acts as a conformational switch, regulating the substrate access to the active site. Additionally, the structural basis of substrate recognition and the catalytic mechanism of the protease are elucidated, mapping determinants of substrate specificity. These insights enable us to design covalent inhibitors to mimic the natural substrates and develop a fluorescence resonance energy transfer (FRET)-based protease assay to effectively assess the inhibitory activity, leading to the discovery of first-in-class inhibitors of MPXV I7L protease with nanomolar potency. Therefore, this work provides a comprehensive understanding of the MPXV I7L protease's structure, dynamics, and function, and presents an example of successful rational design of covalent peptidomimetic inhibitors, serving as a good starting point for drug development against MPXV.}, archive = {J_ADVS}, author = {Haixia Su and Guoqing Wu and Muya Xiong and Yuhang Wang and Junyuan Cao and Mengyuan You and Yingchun Xiang and Tianqing Nie and Minjun Li and Gengfu Xiao and Leike Zhang and Qiang Shao and Yechun Xu}, doi = {10.1002/advs.202501625}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501625}, shortjournal = {Adv. Sci.}, title = {Dynamic cap-mediated substrate access and potent inhibitor design of monkeypox virus I7L protease}, volume = {12}, year = {2025}, }
• (2025). Novel bivalent mRNA-LNP vaccine for highly effective protection against pneumonic plague. ADVS, 12(26), 2501286. (www)

  @article{ , abstract = {Yersinia pestis , the causative agent of plague, remains a significant global health hazard and a potential top-tier biothreat despite modern medical advances. Here, two mRNA constructs encoding different versions of the low-calcium response virulence (LcrV) protective antigen, an essential virulence factor of Y. pestis , are designed and evaluated. Next, the immunogenicity and protective efficacy both independently and in combination is assessed with the previously reported F1-encoding mRNA construct in the well-established mouse model of pneumonic plague. The findings reveal that human Fc-conjugated F1 + LcrV combination mRNA vaccination resulted in significant immune activation and substantial protection against intranasal Y. pestis challenge. Notably, the combined vaccine demonstrates protective efficacy against two highly virulent wild-type Y. pestis strains representing distinct biovars and an atypical, unencapsulated strain. This study represents the first comprehensive evaluation of mRNA constructs encoding innovatively designed versions of LcrV and F1 for pneumonic plague prevention, addressing critical gaps in current vaccination approaches. This study establishes the mRNA-lipid nanoparticle (LNP) platform as a promising tool for addressing bacterial pathogens, including those resistant to antibiotics. By broadening its applicability to diverse threats, this technology represents an innovative approach to tackling some of the most pressing challenges in global health.}, archive = {J_ADVS}, author = {Uri Elia and Yinon Levy and Hila Cohen and Ayelet Zauberman and David Gur and Inbal Hazan-Halevy and Moshe Aftalion and Shani Benarroch and Erez Bar-Haim and Orit Redy-Keisar and Ofer Cohen and Dan Peer and Emanuelle Mamroud}, doi = {10.1002/advs.202501286}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501286}, shortjournal = {Adv. Sci.}, title = {Novel bivalent mRNA-LNP vaccine for highly effective protection against pneumonic plague}, volume = {12}, year = {2025}, }
• (2025). Particle-assisted optoelectronic tweezers for manipulating single cells and microparticles. ADVS, 12(26), 2501032. (www)

  @article{ , abstract = {Manipulation of single cells or particles is crucial in the biomedical field. However, precisely and rapidly manipulating single cells without damaging them is a significant challenge. In this study, a novel strategy for indirect manipulation of cells and microparticles that can satisfy these requirements via a combination of particle-induced dielectrophoretic forces (PiDEP) and optoelectronic tweezers (OET) is developed. This strategy is based primarily on the principle that particles experiencing the same dielectrophoretic forces tend to repel each other, whereas those experiencing different forces are attracted to each other. During the manipulation, Ag-SiO 2 microparticles controlled by the OET act as intermediaries for manipulating other particles or cells through dielectrophoretic forces. Thus, the manipulation range of the OET can be expanded by two to three times its original size, and the manipulation speed can be significantly increased while maintaining its precision. Furthermore, the results indicate that the proposed method can effectively reduce cell damage to one-third of that caused by traditional OET. This study demonstrates the significant potential of particle-assisted OET for single-cell manipulation and offers an effective strategy for manipulating cells and microparticles.}, archive = {J_ADVS}, author = {Ao Wang and Shuzhang Liang and Caiding Ni and Yongyi Jia and Kangjie Wu and Wenyan Niu and Shunxiao Huang and Kaiyi Peng and Chutian Wang and Yingjian Guo and Zhijun Zhao and Lingze Zhang and Mingjie Liu and Lin Feng}, doi = {10.1002/advs.202501032}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2501032}, shortjournal = {Adv. Sci.}, title = {Particle-assisted optoelectronic tweezers for manipulating single cells and microparticles}, volume = {12}, year = {2025}, }
• (2025). Correlations in magnetic sub-domains as an unconventional phase diagram for van der waals ferromagnets. ADVS, 12(26), 2500562. (www)

  @article{ , abstract = {Traditional magnetic phase diagram represents a transition between the ferromagnetic and paramagnetic states of a material under the influence of varied temperature, magnetic field, and pressure. So far, the ferromagnetic phase has been considered predominantly as a single type of magnetization texture extending macroscopically in the bulk of a crystal, existing as a ground state determined by the interactions between localized magnetic moments arranged in a lattice. Here, it is demonstrated that an unconventional magnetic order composed of vertically correlated planar magnetic sub-domains occurs intrinsically in mechanically exfoliated layers of van der Waals ferromagnet CrBr 3 . Based on the visualization of the magnetic textures through magnetic force microscopy in conjunction with the ab initio calculations of the crystal structure in the magnetic phase and micromagnetic simulations, the origin of the magnetic sub-domains is attributed to stacking faults isolating a van der Waals ferromagnetic well from the bulk film due to modifications in the interlayer exchange coupling. This enables to create a phase diagram describing the magnetic states unique to van der Waals ferromagnets in terms of the degree of correlation between the magnetic sub-domains, dependent on the exchange coupling constants and tuneable by magnetic field and temperature.}, archive = {J_ADVS}, author = {Sergey Y. Grebenchuk and Magdalena Grzeszczyk and Zhaolong Chen and Makars Šiškins and Vladislav Borisov and Manuel Pereiro and Mikhail I. Katsnelson and Olle Eriksson and Kostya S. Novoselov and Maciej Koperski}, doi = {10.1002/advs.202500562}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2500562}, shortjournal = {Adv. Sci.}, title = {Correlations in magnetic sub-domains as an unconventional phase diagram for van der waals ferromagnets}, volume = {12}, year = {2025}, }
• (2025). Surface-engineered cenospheres encapsulating phase change materials for functional cementitious composites. ADVS, 12(26), 2417350. (www)

  @article{ , abstract = {The escalating global energy demand underscores the critical need for advanced solutions for energy-efficient buildings. Passive thermal energy storage systems using microencapsulated phase change materials (PCMs) offer promise but face integration challenges in cementitious materials due to weakening mechanical strength, which arises from poor shell strength and weak interfacial bonding with cementitious phases. This study introduces a novel approach for synthesizing functionalized microencapsulated PCMs from fly ash-based cenospheres addressing interfacial compatibility. Cenospheres are perforated for PCM encapsulation and sealed using two different materials: 1) melamine-formaldehyde (MF), a standard polymeric shell; and 2) silica, selected for its chemical compatibility with cementitious phases. Experimental results show that the silica sealing improved mechanical strength by 50% over those of MF, corroborated by molecular dynamic simulations showing silica's binding energy with calcium silicate hydrate exceeded threefold, with more than twice the uniaxial tensile strength. Thermal analyses confirmed the preservation of PCM in both sealing approaches. This work establishes a transformative pathway for advancing PCM-based thermal energy storage in building materials.}, archive = {J_ADVS}, author = {Sahand Rahemipoor and Carsten Kuenzel and Toms Valdemārs Eiduks and Andrei Shishkin and Mohammadreza Izadifar and Neven Ukrainczyk and Eduardus Koenders and Navid Ranjbar}, doi = {10.1002/advs.202417350}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2417350}, shortjournal = {Adv. Sci.}, title = {Surface-engineered cenospheres encapsulating phase change materials for functional cementitious composites}, volume = {12}, year = {2025}, }
• (2025). Single-cell analysis clarifies pathological heterogeneity in tenosynovial giant cell tumor and identifies biomarkers for predicting disease recurrence. ADVS, 12(26), 2415835. (www)

  @article{ , abstract = {Diffuse-type tenosynovial giant cell tumor (D-TGCT) and localized-type tenosynovial giant cell tumor (L-TGCT) share common genomic aberrations and histopathological features, but the former has a more aggressive nature and a higher recurrence rate, leading to worse prognoses for patients. In this study, single-cell RNA sequencing (scRNA-seq) on human D-TGCT and L-TGCT lesions is conducted to discover transcriptional differences. A unique cluster of tumor cells in D-TGCT is identified that regulated differentiation of CD34 + fibroblasts into MMP 3 + fibroblasts or APOE + fibroblasts via COL6A3 − (ITGAV + ITGB8) interaction. The APOE + fibroblasts further activated IL-1B + CCL20 + macrophages through the CXCL12/CXCR4 axis. IL-1B + CCL20 + macrophages and MMP3 + fibroblasts participated in local aggression of D-TGCT. Two effective biomarkers, ROR1 and PRKD1 are also identified and validated, to predict disease recurrence. This study not only clarified the underlying mechanisms of aggressive behavior in D-TGCT but also provided a theoretical basis and potential targets for intervention into and treatment of this disease.}, archive = {J_ADVS}, author = {Yubin Xie and Chen Chen and Fei Wu and Yiman Peng and Jing Su and Yang Zhao and Hongjie Huang and Zhong Alan Li and Yin Pei and Wencui Li and Yi He and Tianchen Xue and Chenxi Cao and Sui Peng and Xin Zhang and Weidong Song}, doi = {10.1002/advs.202415835}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2415835}, shortjournal = {Adv. Sci.}, title = {Single-cell analysis clarifies pathological heterogeneity in tenosynovial giant cell tumor and identifies biomarkers for predicting disease recurrence}, volume = {12}, year = {2025}, }
• (2025). Noninvasive assessment of β-secretase activity through click chemistry-mediated enrichment of neuronal extracellular vesicles to detect alzheimer's disease. ADVS, 12(26), 2415289. (www)

  @article{ , abstract = {Alzheimer's disease (AD), the most prevalent type of dementia, is characterized by a biological process that begins with the development of AD neuropathologic change (ADNPC) while individuals remain asymptomatic. A key molecular hallmark of ADNPC is the accumulation of amyloid-β plaques. β-secretase plays a critical role in the upstream pathological cleavage of amyloid precursor protein (APP), producing amyloid-β peptides that are prone to misfolding, ultimately contributing to plaque formation. Neuronal extracellular vesicles (NEVs) in the blood transport β-secretase and preserve its activity, allowing for noninvasive profiling of β-secretase activity for detecting early onset of ADNPC. In this study, a novel approach is approached for noninvasive assessment of β-secretase activity in AD patients using an NEV β-secretase activity assay. This assay identifies NEVs exhibiting colocalization of NEV markers with AD-associated β-secretase, generating a β-secretase activity profile for each patient. The NEV β-secretase activity assay represents a significant advancement in leveraging the diagnostic potential of NEVs, offering a noninvasive, quantitative method for reliably assessing β-secretase activity to detect the early onset of ADNPC.}, archive = {J_ADVS}, author = {Hyoyong Kim and Junseok Lee and Audrey Qian and You-Ren Ji and Ryan Zhang and Qixin Hu and Christopher Kazu Williams and Han-Yu Chuang and Matthew D. Smalley and Yaya Xu and Liang Gao and Mary C. Mayo and Ting Zhang and Edwin M. Posadas and Zaldy S. Tan and Harry V. Vinters and Keith Vossel and Shino Magaki and Yazhen Zhu and Hsian-Rong Tseng}, doi = {10.1002/advs.202415289}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2415289}, shortjournal = {Adv. Sci.}, title = {Noninvasive assessment of β-secretase activity through click chemistry-mediated enrichment of neuronal extracellular vesicles to detect alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Tumor microenvironment triggered in situ coagulation of supramolecularly engineered platelets for precise tumor embolization. ADVS, 12(26), 2414879. (www)

  @article{ , abstract = {Although embolization therapy has demonstrated success in impeding tumor growth, concerns persist regarding potential tumor recurrence and inadvertent embolization of non-target tissues. In this study, drawing inspiration from the natural targeting and coagulation process of platelets in injured blood vessels, platelets are engineered by integrating acid-sensitive, morphology-transformable nanoparticles onto their surface through supramolecular conjugation (PLT-NP). The nanoparticles are constructed through the self-assembly of a β-amyloid derived peptide (FFVLK) terminally functionalized with Fmoc, hexahistidine (His 6 ), and a polyethylene glycol (PEG)-functionalized cyclodextrin (CD). The supramolecularly engineered platelets actively accumulate in the tumor tissue upon inducing a tumor blood vessel injury through tumor resection. In response to the local acidic microenvironment, the nanoparticles undergo a morphological transformation into nanofibers via spontaneous assembly of FFLVK into fibril structures through hydrogen bonding and β-sheet interactions, to artificially enhance the coagulation and aggregation of platelets, causing occlusion of tumor blood vessels. The supramolecularly engineered platelets efficiently embolize tumor blood vessels in a specific manner, effectively suppressing tumor growth, metastasis, and recurrence, thus offering a promising paradigm for combating cancer.}, archive = {J_ADVS}, author = {Junyan Li and Ziyi Wang and Ruifeng Luo and Xingping Quan and Hong U Fong and Qian Cheng and Jianwen Wei and Leo Wang and Yonghua Zhao and Ruibing Wang}, doi = {10.1002/advs.202414879}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2414879}, shortjournal = {Adv. Sci.}, title = {Tumor microenvironment triggered in situ coagulation of supramolecularly engineered platelets for precise tumor embolization}, volume = {12}, year = {2025}, }
• (2025). Enhancing grasping function with a thermoresponsive ionogel adhesive glove for patients with rheumatic diseases. ADVS, 12(26), 2414761. (www)

  @article{ , abstract = {Rheumatic diseases often result in joint deformities and peripheral nerve damage, leading to impaired hand function. Current wearable assistive gloves commonly rely on external forces to flex fingers for grasping, but they face limitations such as bulky hardware, complex finger manipulation, and a risk of joint injuries. This study presents a lightweight, portable, soft wearable adhesive glove based on thermoresponsive ionogels aimed at enhancing grasping function. The ionogel exhibits high adhesion (≈35 kPa to various materials) at 25 °C and low adhesion (≈6.8 kPa) at 45 °C. Smart adhesive pads use embedded flexible heaters and temperature sensors for closed-loop control of the ionogels’ temperature, providing programmable adhesion. A rapid switch from high to low adhesion is achieved within 4 s at 4 V. Additionally, a hands-free control interface uses inertial measurement units to detect the user's intent to release, facilitating easy and intuitive detachment. Weighing only 47 g, the glove is 7.2 times lighter than existing assistive gloves. Notably, it empowers users to grasp and release a variety of objects that will otherwise be unmanageable. Evaluation of various activities of daily living demonstrates that the glove significantly enhances grasping ability and increases autonomy for patients with rheumatic diseases.}, archive = {J_ADVS}, author = {Shiqiang Wang and Shiqing Liu and Jingfeng Zhang and Zhouyang Yu and Yifan Shao and Cong Zhao and Jiahong Ma and Xin Fu and Mengqi Yang and Lie Chen and Mingjie Liu and Li Wen}, doi = {10.1002/advs.202414761}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2414761}, shortjournal = {Adv. Sci.}, title = {Enhancing grasping function with a thermoresponsive ionogel adhesive glove for patients with rheumatic diseases}, volume = {12}, year = {2025}, }
• (2025). Isolation techniques of Micro/Nano-scaled species for biomedical applications. ADVS, 12(26), 2414109. (www)

  @article{ , abstract = {Isolation of micro/nano-scaled bioparticles, such as circulating tumor cells (CTCs), exosomes, bacteria, white blood cells (WBCs), platelets, and viruses, from the sample is essential for cancer diagnosis and treatment, preventing bacterial infections, and monitoring human health. Numerous separation techniques, including magnetophoresis, dielectrophoresis, acoustophoresis, optophoresis, and fluorescence-activated sorting (FAS) have been developed to isolate the target bioparticles from complex samples accurately. However, these active methods usually rely on sophisticated instruments which are expensive and bulky. Passive platforms with high throughput, low cost, and small volume have gradually become alternative methods. Alongside this context, this review paper is no longer confined to one specific category of isolation techniques, advanced systems that have been developed in recent years are comprehensively introduced. Characteristics and limitations of each technology are discussed according to the critical performance parameters including purity, recovery rate, throughput, resolution, size, and convenience. Specific biomedical applications of separation techniques are summarized to provide practical implications for disease diagnosis, treatment, and mechanism research. This review also addresses the current challenges, potential solutions, and prospects in this field, laying the foundation for further optimization, innovation, and cross-integration of isolation techniques in the future.}, archive = {J_ADVS}, author = {Qing Lu and Zhinan Zhang and Xianting Ding}, doi = {10.1002/advs.202414109}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2414109}, shortjournal = {Adv. Sci.}, title = {Isolation techniques of Micro/Nano-scaled species for biomedical applications}, volume = {12}, year = {2025}, }
• (2025). Ultra-low LOD H2O2 sensor based on synergistic nernst potential effect. ADVS, 12(26), 2413898. (www)

  @article{ , abstract = {The food processing industry and biomedical science research are relying on the low limit of detection (LOD) for hydrogen peroxide (H 2 O 2 ). Organic electrochemical transistors (OECTs) are excellent for biochemical sensing applications due to their excellent signal amplification capability. The paper describes  a way of detecting H 2 O 2 through the use of stacked poly(3,4-ethylenedioxythiophene): bromothymol blue (PEDOT: BTB)/poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT: PSS) as the semiconducting channel of the OECT. The H 2 O 2 sensor presents an ultra-low LOD, down to 1.8 × 10 −12 M, due to the synergistic effect of the Nernst potential generated by the platinum gate electrode catalyzing H 2 O 2 and the Nernst potential generated by the interaction between BTB molecules and hydrogen ions, the by-product of H 2 O 2 catalysis. A microsystemwith a signal processing circuit and a mobile app for the sensor has been developed, and they are then tested on commercial milk samples to verify their reliability. Since the majority of enzyme-catalyzed reactions generate or use H 2 O 2 in biochemical reactions, the methodology is applicable not only to the detection of H 2 O 2 but also to the detection of analytes based on enzyme-catalyzed reactions. For demonstration, glucose detection with a LOD of down to 8.82 × 10 −11 M is also presented.}, archive = {J_ADVS}, author = {Zhaoqun Wang and Wen Gao and Xiaorong Niu and Yuhang Liu and Zichen Jin and Fan Zhang and Zhengdong Cheng and Xiaoning Jiang and Wendong Zhang and Ting Wang and Jianlong Ji and Xiaojie Chai and Shengbo Sang}, doi = {10.1002/advs.202413898}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2413898}, shortjournal = {Adv. Sci.}, title = {Ultra-low LOD H2O2 sensor based on synergistic nernst potential effect}, volume = {12}, year = {2025}, }
• (2025). HIC1 suppresses tumor progression and enhances CD8+ t cells infiltration through promoting GSDMD-induced pyroptosis in gastric cancer. ADVS, 12(26), 2412083. (www)

  @article{ , abstract = {Recently, immune checkpoint blockade treatment has made remarkable strides in combatting malignancies, including gastric cancer (GC). Nonetheless, the efficacy of immunotherapy in GC patients remains constrained, warranting further exploration of the underlying molecular mechanisms to improve therapeutic outcomes. Hypermethylated in cancer 1 (HIC1) is acknowledged as a transcriptional regulator crucial for multiple aspects of cell development, yet its role in antitumor immune responses remains incompletely understood. This investigation reveals a significant downregulation of HIC1 in gastric cancer, correlating with a less favorable prognosis. Overexpression of HIC1 promotes the initiation of cell pyroptosis. Mechanistically, gasdermin D (GSDMD), a pivotal executor of pyroptosis, is identified as a downstream target of HIC1 and activated by HIC1 at the transcriptional level. Subsequent cleavage of the GSDMD N-terminal region punctures the cell membrane, instigating pyroptosis and releasing inflammatory factors. Furthermore, HIC1 augments the infiltration of CD8 + T cells to counteract immune evasion. The combinatorial approach of HIC1 overexpression with PD-L1 antibody demonstrates a synergistic therapeutic impact in treating GC. Additionally, c-Jun activation domain-binding protein 1 (Jab1) mediates the ubiquitylation and proteasomal degradation of HIC1 at Lys 517 . Ultimately, these findings underscore the potential of HIC1 as a promising immunotherapeutic target for the treatment of GC.}, archive = {J_ADVS}, author = {Mengjie Kang and Wenqi Du and Lina Ding and Mengdi Wu and Dongsheng Pei}, doi = {10.1002/advs.202412083}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2412083}, shortjournal = {Adv. Sci.}, title = {HIC1 suppresses tumor progression and enhances CD8+ t cells infiltration through promoting GSDMD-induced pyroptosis in gastric cancer}, volume = {12}, year = {2025}, }
• (2025). β-glucuronidase-expressing lactobacillus reuteri triggers irinotecan enterotoxicity through depleting the regenerative epithelial Stem/Progenitor pool. ADVS, 12(26), 2411052. (www)

  @article{ , abstract = {Irinotecan (CPT11)-induced diarrhea affects 80–90% of cancer patients due to β-glucuronidase (GUS) converting 7-ethyl-10-hydroxycamptothecin glucuronide (SN38G) to 7-ethyl-10-hydroxycamptothecin (SN38). It remains unclear whether SN38 impacts the homeostasis between gut microbiota and mucosal stem cell niche. This study explores the crosstalk between gut microbiota and intestinal stem cells (ISCs) in intestinal mucositis triggered by CPT11 chemotherapy. CPT11-treated mice exhibited significant colon shortening, inflammatory infiltration, intestinal barrier dysfunction, and ISC impairment, which correlated with gut dysbiosis, enrichment of GUS-expressing bacteria, and intraluminal SN38 accumulation. In contrast, antidiarrheal (Xianglian pill) treatment alleviated SN38-induced enterotoxicity and reduced GUS-expressing bacterial populations. Microbiome profiling of clinical patients and mucositis mice revealed a strong correlation between CPT11/SN38 enterotoxicity and GUS-expressing bacteria, particularly Lactobacillus reuteri . PLS-PM modeling further linked L. reuteri to impaired epithelial regeneration, which is validated using a 3D intestinal organoid model. L. reuteri hindered ISC differentiation into secretory lineages within the organoids. Furthermore, L. reuteri colonization in mice exacerbated mucositis and disrupted epithelial differentiation, while its elimination ameliorated colitis symptoms and preserved crypt cell stemness. These findings suggest that selectively targeting GUS-expressing bacteria, particularly L. reuteri, to protect the regenerative epithelial stem/progenitor pool may serve as an effective strategy for mitigating CPT11-induced enterotoxicity.}, archive = {J_ADVS}, author = {Bei Yue and Ruiyang Gao and Ling Zhao and Donghui Liu and Cheng Lv and Ziyi Wang and Fangbin Ai and Beibei Zhang and Zhilun Yu and Xiaolong Geng and Hao Wang and Kang Wang and Kaixian Chen and Chenghai Liu and Zhengtao Wang and Wei Dou}, doi = {10.1002/advs.202411052}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2411052}, shortjournal = {Adv. Sci.}, title = {β-glucuronidase-expressing lactobacillus reuteri triggers irinotecan enterotoxicity through depleting the regenerative epithelial Stem/Progenitor pool}, volume = {12}, year = {2025}, }
• (2025). Molecular interlayer for high-performance and stable 2D tin halide perovskite transistor. ADVS, 12(26), 2409088. (www)

  @article{ , abstract = {Tin (Sn) halide perovskites present considerable potential for the advancement of high-performance p-channel field-effect transistors (FETs), attributable to their low hole effective mass and reduced carrier scattering. However, their intrinsic instability has impeded their ability to achieve the anticipated performance benchmarks. In this study, molecular interlayers are designed that not only passivate surface defects in Sn perovskites through their functional groups, leading to improved film formation and consequently enhanced performance and stability but also reduce the energy barrier at the source and drain interfaces through their strong dipole moments, thereby enhancing carrier transport. These synergistic effects result in FET devices exhibiting remarkable performance metrics, including effective mobility exceeding 11 cm 2 V −1 s −1 and an on/off ratio greater than 1.3 × 10 7 while securing exceptional durability and reproducibility. Furthermore, the hydrophobic characteristics of the surface interlayer confer superior storage stability.}, archive = {J_ADVS}, author = {Bum Ho Jeong and Juan Anthony Prayogo and Jongmin Lee and Seok Woo Lee and Dong Ryeol Whang and Dong Wook Chang and Hui Joon Park}, doi = {10.1002/advs.202409088}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2409088}, shortjournal = {Adv. Sci.}, title = {Molecular interlayer for high-performance and stable 2D tin halide perovskite transistor}, volume = {12}, year = {2025}, }
• (2025). Altered brain-behavior association during resting state is a potential psychosis risk marker. ADVS, 12(26), 2405700. (www)

  @article{ , abstract = {Alterations in cognitive and neuroimaging measures in psychosis may reflect altered brain-behavior interactions patterns accompanying the symptomatic manifestation of the disease. Using graph connectivity-based approaches, we tested the brain-behavior association between cognitive functioning and functional connectivity at different stages of psychosis. We collected resting-state fMRI of 204 neurotypical controls (NC) in two independent cohorts, 43 patients with chronic psychosis (PSY), and 22 subjects with subthreshold psychotic symptoms (STPS). In NC, we calculated graph connectivity metrics and tested their associations with neuropsychological scores. Replicable associations were tested in PSY and STPS and externally validated in three cohorts of 331, 371, and 232 individuals, respectively. NC showed a positive correlation between the degree centrality of a right prefrontal-cingulum-striatal circuit and total errors on Wisconsin Card Sorting Test. Conversely, PSY and STPS showed negative correlations. External replications confirmed both associations while highlighting the heterogeneity of STPS. Group differences in either centrality or cognition alone were not equally replicable. In four independent cohorts totaling 1,203 participants, we identified a replicable alteration of the brain-behavior association in different stages of psychosis. These results highlight the high replicability of multimodal markers and suggest the opportunity for longitudinal investigations that may test this marker for early risk identification.}, archive = {J_ADVS}, author = {Leonardo Fazio and Giuseppe Stolfa and Roberta Passiatore and Angelantonio Tavella and Giuseppe Blasi and Madalina O. Buciuman and Aaron L. Goldman and Shalaila S. Haas and Lana Kambeitz-Ilankovic and Nikolaos Koutsouleris and Monica Nicoli and Teresa Popolizio and Antonio Rampino and Anne Ruef and Fabio Sambataro and Pierluigi Selvaggi and William Ulrich and Daniel R. Weinberger and Alessandro Bertolino and Linda A. Antonucci and Giulio Pergola}, doi = {10.1002/advs.202405700}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2405700}, shortjournal = {Adv. Sci.}, title = {Altered brain-behavior association during resting state is a potential psychosis risk marker}, volume = {12}, year = {2025}, }
• (2025). FUS selectively facilitates circRNAs packing into small extracellular vesicles within hypoxia neuron. ADVS, 12(26), 2404822. (www)

  @article{ , abstract = {Small extracellular vesicles (sEVs) contain abundant circular RNAs (circRNAs) and are involved in cellular processes, particularly hypoxia. However, the process that packaging of circRNAs into neuronal sEVs under hypoxia is unclear. This study revealed the spatial mechanism of the Fused in Sarcoma protein (FUS) that facilitates the loading of functional circRNAs into sEVs in hypoxia neurons. It is found that FUS translocated from the nucleus to the cytoplasm and is more enriched in hypoxic neuronal sEVs than in normal sEVs. Cytoplasmic FUS formed aggregates with the sEVs marker protein CD63 in cytoplasmic stress granules (SGs) under hypoxic stress. Meanwhile, cytoplasmic FUS recruited of functional cytoplasmic circRNAs to SGs. Upon relief of hypoxic stress and degradation of SGs, cytoplasmic FUS is transported with those circRNAs from SGs to sEVs. Validation of FUS knockout dramatically reduced the recruitment of circRNAs from SGs and led to low circRNA loading in sEVs, which is also confirmed by the accumulation of circRNAs in the cytoplasm. Furthermore, it is showed that the FUS Zf_RanBP domain regulates the transport of circRNAs to sEVs by interacting with hypoxic circRNAs in SGs. Overall, these findings have revealed a FUS-mediated transport mechanism of hypoxia-related cytoplasmic circRNAs loaded into sEVs under hypoxic conditions.}, archive = {J_ADVS}, author = {Jiankun Zang and Yousheng Wu and Xuanlin Su and Kaiwei Cai and Man Ke and Niu He and Huili Zhu and Zefeng Tan and Jielin Zhu and Wensheng He and Min Peng and Shiqing Zhang and Hongcheng Mai and Anding Xu and Dan Lu}, doi = {10.1002/advs.202404822}, journal = {Advanced Science}, month = {7}, number = {26}, pages = {2404822}, shortjournal = {Adv. Sci.}, title = {FUS selectively facilitates circRNAs packing into small extracellular vesicles within hypoxia neuron}, volume = {12}, year = {2025}, }
• (2025). Locus coeruleus noradrenergic-spinal projections contribute to electroacupuncture-mediated antinociception in postoperative pain in mice. ADVS, 12(25), e01182. (www)

  @article{ , abstract = {Postoperative pain remains a significant challenge in healthcare. Electroacupuncture (EA) has gained polarity in helping manage surgical pain and showed beneficial effects on enhancing postoperative analgesia, decreasing opioid requirement. Despite this, the precise mechanisms underlying these actions are poorly understood. Evidence shows the involvement of noradrenaline (NE) in the action of EA. However, the precise identity of the NE source after EA treatment, its mechanisms of action, and the circuitry locus in the pain-regulating pathway remain elusive. It is shown that plantar incision (PI) leads to hypoactivity of noradrenergic neurons in the locus coeruleus (LC), which brings about impaired NE release in the spinal dorsal horn (SDH). EA treatment normalizes the abnormal hypoexcitability of LC noradrenergic neurons after PI and thus triggers enhanced NE release in the SDH. Optogenetic inhibition of LC noradrenergic neurons eliminates EA-induced NE release and antinociceptive effects after PI, while activation of these neurons mimics EA-induced NE release and antinociception. The resultant increased NE release after EA activates spinal α 2A -adrenoceptor and inhibits CaMKII signaling, which in turn depresses spinal excitatory neuronal hyperexcitability and eventually relieves postoperative pain. It is concluded that LC noradrenergic-spinal projections and subsequent α 2A -adrenoceptor–CaMKII signaling cascades in the SDH contribute to EA-induced antinociception in postoperative pain.}, archive = {J_ADVS}, author = {Wen-Guang Chu and Ru Zhang and Hai-Tao Li and Ying-Chun Li and Hui Ding and Zhen-Zhen Li and Wen-Juan Han and Fei Wang and Xing-Xing Zheng and Hong-Hui Mao and Hua Yuan and Sheng-Xi Wu and Rou-Gang Xie and Ceng Luo}, doi = {10.1002/advs.202501182}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {e01182}, shortjournal = {Adv. Sci.}, title = {Locus coeruleus noradrenergic-spinal projections contribute to electroacupuncture-mediated antinociception in postoperative pain in mice}, volume = {12}, year = {2025}, }
• (2025). Dynamic and stable core microbiota assist plants in enriching selenium and reducing cadmium absorption. ADVS, 12(25), e00862. (www)

  @article{ , abstract = {Rhizosphere microbiome is crucial for regulating rhizosphere complex nutrient dynamics. However, mechanisms by which plants regulate rhizosphere microbes to manage nutrient availability under coexisting beneficial and harmful elements remain unclear. This study focuses on the rhizosphere microbiome of Brassica napus in different naturally selenium (Se)–cadmium (Cd)-rich soils, the functionality of this rhizosphere, and the changes in the availability of rhizosphere nutrients. Microbiome analysis, metagenomics, genomic analysis, strain isolation, and functional validation are performed to investigate these relationships. Results show that a significant negative correlation is observed between the rhizosphere available Se and Cd content across the plant whole growth cycle and identified a group of core microbiota that are highly positively correlated with available Se and negatively correlated with available Cd. Genomics and metagenomics analyses reveal that the core microbiota has a higher substrate preference for amino acids related to the glutathione metabolic pathway. Key glutathione-related-amino acids and synthetic microbial community significantly improve the expression of glutathione anabolism and related amino acid transport genes and enhance Se uptake and reduce Cd absorption in plants grown in various Se-Cd-rich soils. This study provides insights into the mechanisms of root-associated microbes responding to complex soil nutrients during plant growth.}, archive = {J_ADVS}, author = {Zheng Lei and Hua Zhang and Wenju Liu and Jiandong Sheng and Huan Zhang and Yin Wang and Yanni Tang and Huaxing Wang and Cuicui Ding and Wanqi Qiao and Yonghui Zhu and Guoyin Yang and Yihan Zhang and Zhuoyi Liu and Nanyu Zhou and Chengxiao Hu and Xiaohu Zhao}, doi = {10.1002/advs.202500862}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {e00862}, shortjournal = {Adv. Sci.}, title = {Dynamic and stable core microbiota assist plants in enriching selenium and reducing cadmium absorption}, volume = {12}, year = {2025}, }
• (2025). EccDNA-driven VPS41 amplification alleviates genotoxic stress via lysosomal KAI1 degradation (Adv. sci. 25/2025). ADVS, 12(25), 2570197. (www)

  @article{ , archive = {J_ADVS}, author = {Bin Shi and Ping Yang and Huaijin Qiao and Jinchen He and Bin Song and Hao Bai and Fengdi Jiang and Yining Zhang and Qian Li and Tao Yan and Wenlin Tu and Daojiang Yu and Shuyu Zhang}, doi = {10.1002/advs.202570197}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2570197}, shortjournal = {Adv. Sci.}, title = {EccDNA-driven VPS41 amplification alleviates genotoxic stress via lysosomal KAI1 degradation (Adv. sci. 25/2025)}, volume = {12}, year = {2025}, }
• (2025). Collaborative duality of CircGLIS3(2) RNA and protein in human wound repair (Adv. sci. 25/2025). ADVS, 12(25), 2570196. (www)

  @article{ , archive = {J_ADVS}, author = {Guanglin Niu and Maria A. Toma and Jennifer Geara and Xiaowei Bian and Yongjian Chen and Lihua Luo and Qizhang Wang and Yunting Xiao and Manika Vij and Minna Piipponen and Zhuang Liu and Sho Oasa and Letian Zhang and Dörte Schlesinger and Ákos Végvári and Dongqing Li and Aoxue Wang and Vladana Vukojević and Simon J Elsässer and Pehr Sommar and Ning Xu Landén}, doi = {10.1002/advs.202570196}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2570196}, shortjournal = {Adv. Sci.}, title = {Collaborative duality of CircGLIS3(2) RNA and protein in human wound repair (Adv. sci. 25/2025)}, volume = {12}, year = {2025}, }
• (2025). Surface engineering-induced d-band center down-regulation in high-entropy alloy nanowires for enhanced nanozyme catalysis (Adv. sci. 25/2025). ADVS, 12(25), 2570195. (www)

  @article{ , archive = {J_ADVS}, author = {Kunyang Feng and Hanting Wang and Song Zhou and Wei Zhang and Chonghai Gong and Yuxin He and Yusen Wang and Wenchong Dai and Jianbo Li and Zhengwei Zhang and Siqiao Li}, doi = {10.1002/advs.202570195}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2570195}, shortjournal = {Adv. Sci.}, title = {Surface engineering-induced d-band center down-regulation in high-entropy alloy nanowires for enhanced nanozyme catalysis (Adv. sci. 25/2025)}, volume = {12}, year = {2025}, }
• (2025). Advancements in bio-integrated flexible electronics for hemodynamic monitoring in cardiovascular healthcare (Adv. sci. 25/2025). ADVS, 12(25), 2570194. (www)

  @article{ , archive = {J_ADVS}, author = {Ke Huang and Zhiqiang Ma and Bee Luan Khoo}, doi = {10.1002/advs.202570194}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2570194}, shortjournal = {Adv. Sci.}, title = {Advancements in bio-integrated flexible electronics for hemodynamic monitoring in cardiovascular healthcare (Adv. sci. 25/2025)}, volume = {12}, year = {2025}, }
• (2025). Accurate and noninvasive dysphagia assessment via a soft high-density sEMG electrode array conformal to the submental and infrahyoid muscles (Adv. sci. 25/2025). ADVS, 12(25), 2570192. (www)

  @article{ , archive = {J_ADVS}, author = {Weijie Hong and Lin Mao and Kai Lin and Chongyuan Huang and Yanyan Su and Shun Zhang and Chengjun Wang and Daming Wang and Jizhou Song and Zuobing Chen}, doi = {10.1002/advs.202570192}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2570192}, shortjournal = {Adv. Sci.}, title = {Accurate and noninvasive dysphagia assessment via a soft high-density sEMG electrode array conformal to the submental and infrahyoid muscles (Adv. sci. 25/2025)}, volume = {12}, year = {2025}, }
• (2025). Active sites-enriched hierarchical weyl semimetal WTe2 nanowire arrays for highly efficient hydrogen evolution reaction (Adv. sci. 25/2025). ADVS, 12(25), 2570191. (www)

  @article{ , archive = {J_ADVS}, author = {Hyeonkyeong Kim and Youngdong Yoo}, doi = {10.1002/advs.202570191}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2570191}, shortjournal = {Adv. Sci.}, title = {Active sites-enriched hierarchical weyl semimetal WTe2 nanowire arrays for highly efficient hydrogen evolution reaction (Adv. sci. 25/2025)}, volume = {12}, year = {2025}, }
• (2025). Self-propelled in situ polymerized nanoparticles activating the STING pathway for enhanced bladder cancer immunotherapy (Adv. sci. 25/2025). ADVS, 12(25), 2570190. (www)

  @article{ , archive = {J_ADVS}, author = {Lei Peng and Anguo Zhao and Rongkang Li and Yujun Liu and Daitian Tang and Dashi Deng and Qi Zhuang and Rui Liang and Shaohua Zhang and Song Wu}, doi = {10.1002/advs.202570190}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2570190}, shortjournal = {Adv. Sci.}, title = {Self-propelled in situ polymerized nanoparticles activating the STING pathway for enhanced bladder cancer immunotherapy (Adv. sci. 25/2025)}, volume = {12}, year = {2025}, }
• (2025). Robustly repeatable, permeable, and multi-axially stretchable, adhesive bioelectronics with super-adaptive conductive suction cups for continuously deformable biosurfaces (Adv. sci. 25/2025). ADVS, 12(25), 2570189. (www)

  @article{ , archive = {J_ADVS}, author = {Gyun Ro Kang and Gui Won Hwang and Dohyun Lim and Seung Hwan Jeon and Minwoo Song and Chan-Hwa Hong and Hye Jin Kim and Changhyun Pang}, doi = {10.1002/advs.202570189}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2570189}, shortjournal = {Adv. Sci.}, title = {Robustly repeatable, permeable, and multi-axially stretchable, adhesive bioelectronics with super-adaptive conductive suction cups for continuously deformable biosurfaces (Adv. sci. 25/2025)}, volume = {12}, year = {2025}, }
• (2025). Trypstatin as a novel TMPRSS2 inhibitor with broad-spectrum efficacy against corona and influenza viruses. ADVS, 12(25), 2506430. (www)

  @article{ , abstract = {Respiratory viruses, such as SARS-CoV-2 and influenza, exploit host proteases like TMPRSS2 for entry, making TMPRSS2 a prime antiviral target. Here, the identification and characterization of Trypstatin, a 61-amino acid Kunitz-type protease inhibitor derived from human hemofiltrate are reported. Trypstatin inhibits TMPRSS2 and related proteases with high potency, exhibiting half-maximal inhibitory concentration values in the nanomolar range, comparable to the small molecule inhibitor camostat mesylate. In vitro assays demonstrate that Trypstatin effectively blocks spike-driven entry of SARS-CoV-2, SARS-CoV-1, MERS-CoV, and hCoV-NL63, as well as hemagglutinin-mediated entry of influenza A and B viruses. In primary human airway epithelial cultures, Trypstatin significantly reduces SARS-CoV-2 replication and retained activity in the presence of airway mucus. In vivo, intranasal administration of Trypstatin to SARS-CoV-2-infected Syrian hamsters reduces viral titers and alleviates clinical symptoms. These findings highlight Trypstatin's potential as a broad-spectrum antiviral agent against TMPRSS2-dependent respiratory viruses.}, archive = {J_ADVS}, author = {Jan Lawrenz and Lukas Wettstein and Armando Rodríguez Alfonso and Rayhane Nchioua and Pascal von Maltitz and Dan Pascal Jean Albers and Fabian Zech and Julie Vandeput and Lieve Naesens and Giorgio Fois and Veronika Neubauer and Nico Preising and Emilia Schmierer and Yasser Almeida-Hernandez and Moritz Petersen and Ludger Ständker and Sebastian Wiese and Peter Braubach and Manfred Frick and Eberhard Barth and Daniel Sauter and Frank Kirchhoff and Elsa Sanchez-Garcia and Annelies Stevaert and Jan Münch}, doi = {10.1002/advs.202506430}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2506430}, shortjournal = {Adv. Sci.}, title = {Trypstatin as a novel TMPRSS2 inhibitor with broad-spectrum efficacy against corona and influenza viruses}, volume = {12}, year = {2025}, }
• (2025). Correction to “Liposomal antibiotic booster potentiates carbapenems for combating NDMs-producing escherichia coli”. ADVS, 12(25), 2506344. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202506344}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2506344}, shortjournal = {Adv. Sci.}, title = {Correction to “Liposomal antibiotic booster potentiates carbapenems for combating NDMs-producing escherichia coli”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Inhibition of CDH11 activates cGAS-STING by stimulating branched chain amino acid catabolism and mitigates lung metastasis of adenoid cystic carcinoma”. ADVS, 12(25), 2504992. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202504992}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2504992}, shortjournal = {Adv. Sci.}, title = {Correction to “Inhibition of CDH11 activates cGAS-STING by stimulating branched chain amino acid catabolism and mitigates lung metastasis of adenoid cystic carcinoma”}, volume = {12}, year = {2025}, }
• (2025). PP2A promotes the symmetric division of MUC1-dominant cancer stem-like cells in small cell lung cancer. ADVS, 12(25), 2503545. (www)

  @article{ , abstract = {Small cell lung cancer (SCLC) is the most aggressive and lethal subtype of lung cancer. Cancer stem-like cells (CSLCs) are primarily responsible for carcinogenesis, therapeutic resistance, and tumor recurrence. This study reported that high level of mucin1 (MUC1) is associated with poor patient survival in SCLC. MUC1 expression peaks during the G2/M phase and facilitates symmetric division and expansion of CSLCs. Mechanistically, the interaction of MUC1 and protein phosphatase 2A (PP2A) results in augmented PP2A activity, which leads to reduced phosphorylation of protein kinase C ζ (PKCζ), ultimately decreases phosphorylation of NUMB. Both pharmacological and genetic strategies demonstrate that targeted-inhibition of the MUC1-PP2A axis pointedly rescues phosphorylation of PKCζ and NUMB, thereby shifting CSLCs towards asymmetric division and represses CSLCs proliferation. Conversely, inhibitor of PKCζ suppresses phosphorylation of NUMB, promotes symmetric division and induces enrichment of CSLCs. Moreover, combination of etoposide and inhibitors of MUC1-PP2A pathway efficiently constrains tumor growth in vitro and in vivo. Importantly, a negative correlation is observed between MUC1 and phosphorylation of PKCζ and NUMB in SCLC patients. Therefore, this study reveals a novel mechanism by which MUC1-PP2A awakes CSLC expansion via switching symmetric division, suggesting a potential therapeutic strategy for MUC1-positive SCLC.}, archive = {J_ADVS}, author = {Shengze Li and Xinran Dong and Kexing Gao and Yiyang Wang and Min Li and Huayun Deng and Shuangyu Ma and Yaping Lv and Wei Jin and Quanfu Li and Yuming Wang and Xiaodong Liao and Kangjing Bian and Aiwu Zhou and Chengping Hu and Lei Huang}, doi = {10.1002/advs.202503545}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2503545}, shortjournal = {Adv. Sci.}, title = {PP2A promotes the symmetric division of MUC1-dominant cancer stem-like cells in small cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). Self-propelled in situ polymerized nanoparticles activating the STING pathway for enhanced bladder cancer immunotherapy. ADVS, 12(25), 2502750. (www)

  @article{ , abstract = {Bladder cancer, a common malignancy of the urinary tract, presents complex therapeutic challenges, thereby necessitating the exploration of innovative treatment strategies. This study introduces a novel, self-propelled nanomedicine delivery system that forms nanoparticles within the bladder lumen by co-infusing dopamine hydrochloride, Mn 2+ , cGAMP, and urease into the bladder to initiate in situ polymerization. The resulting Mn-cGAMP@PDA-urease (DMCU) nanoparticles possess a urease-modified surface, which acts as an engine to generate propulsive force by breaking down urea. Consequently, this process enhances nanoparticle retention in the bladder mucosa and facilitates efficient drug delivery. The self-assembled nanoparticles activate the STING pathway, promoting dendritic cell maturation and activation of T cells, thereby enhancing anti-tumor immune responses. These nanoparticles remain in the bladder for an extended period, significantly improving therapeutic efficacy by sustaining drug release and reducing adverse side effects. In vivo, experiments using a mouse orthotopic model of bladder cancer demonstrate that the DMCU system enhances tumor suppression and immune activation compared with conventional therapies. This novel approach integrates nanotechnology with immunomodulation to address chemotherapy resistance and improve therapeutic efficacy.}, archive = {J_ADVS}, author = {Lei Peng and Anguo Zhao and Rongkang Li and Yujun Liu and Daitian Tang and Dashi Deng and Qi Zhuang and Rui Liang and Shaohua Zhang and Song Wu}, doi = {10.1002/advs.202502750}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2502750}, shortjournal = {Adv. Sci.}, title = {Self-propelled in situ polymerized nanoparticles activating the STING pathway for enhanced bladder cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Isotope-enriched cubic boron arsenide with ultrahigh thermal conductivity. ADVS, 12(25), 2502544. (www)

  @article{ , abstract = {High thermal conductivity materials are critical for advanced thermal management applications. The semiconductor cubic boron arsenide (c-BAs) has drawn significant attention due to its ultrahigh thermal conductivity. In this study, high-quality isotope-enriched cubic boron arsenide (c- 10 BAs and c- 11 BAs) crystals are synthesized to further enhance the thermal conductivity of c-BAs and measured a room temperature thermal conductivity of 1500 W m −1 K −1 for the c- 11 BAs. This value is the highest thermal conductivity for isotope-enriched c-BAs reported so far. The experimental study, together with ab initio calculation, verifies the high quality with reproducibility of the crystals. The exceptionally high thermal conductivity of the isotope-enriched BAs, combined with their semiconductor properties, holds significant potential for improving thermal management in semiconductor devices and electronics packaging applications.}, archive = {J_ADVS}, author = {Jaehoon Kim and Dongwook Lee and Huan Wu and Joon Sang Kang}, doi = {10.1002/advs.202502544}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2502544}, shortjournal = {Adv. Sci.}, title = {Isotope-enriched cubic boron arsenide with ultrahigh thermal conductivity}, volume = {12}, year = {2025}, }
• (2025). Surface engineering-induced d-band center down-regulation in high-entropy alloy nanowires for enhanced nanozyme catalysis. ADVS, 12(25), 2502354. (www)

  @article{ , abstract = {High-entropy alloys (HEAs) have garnered extensive attention owing to their broad compositional tunability and high catalytic activity. However, precisely modulating the enzyme-like activity of HEAs and enhancing their biocompatibility for biological applications remain severely challenging. Herein, PtRuFeCoNi HEA nanowires (NWs) are synthesized by adjusting the metal composition and surface-engineered with polydopamine (PDA) to form HEA NWs@PDA nanozymes (HEzymes@PDA) with superior catalytic activity and photothermal properties. Density functional theory calculations and the Sabatier principle reveal that self-polymerized PDA surface engineering moderately lowers the d-band center of the HEAs, optimizes the surface charge distribution, and enhances the adsorption–desorption efficiency of the substrates. As a proof-of-concept, the HEzymes@PDA are synergistically integrated with hydrogels for biosensing analysis. This study presents an innovative paradigm for designing highly active HEA nanozymes via surface engineering and demonstrates their immense potential in catalytic sensing applications.}, archive = {J_ADVS}, author = {Kunyang Feng and Hanting Wang and Song Zhou and Wei Zhang and Chonghai Gong and Yuxin He and Yusen Wang and Wenchong Dai and Jianbo Li and Zhengwei Zhang and Siqiao Li}, doi = {10.1002/advs.202502354}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2502354}, shortjournal = {Adv. Sci.}, title = {Surface engineering-induced d-band center down-regulation in high-entropy alloy nanowires for enhanced nanozyme catalysis}, volume = {12}, year = {2025}, }
• (2025). Unveiling surface species formed on ni-fe spinel oxides during the oxygen evolution reaction at the atomic scale. ADVS, 12(25), 2501967. (www)

  @article{ , abstract = {Optimizing electrocatalyst performance requires an atomic-scale understanding of surface state changes and how those changes affect activity and stability during the reaction. This is particularly important for the oxygen evolution reaction (OER) since the electrocatalytically active surfaces undergo substantial reconstruction and transformation. Herein, a multimodal method is employed that combines X-ray photoemission spectroscopy, transmission electron microscopy, atom probe tomography, operando surface-enhanced Raman spectroscopy with electrochemical measurements to examine the surface species formed on NiFe 2 O 4 , P-doped NiFe 2 O 4 and Ni 1.5 Fe 1.5 O 4 upon OER cycling. The activated NiFe 2 O 4 and P-doped NiFe 2 O 4 exhibit a significantly lower Tafel slope (≈40 mV dec −1 ) than Ni 1.5 Fe 1.5 O 4 (≈90 mV dec −1 ), although oxyhydroxides are grown on all three Ni-Fe spinels during OER. This is likely attributed to the formation of a ≈1 nm highly defective layer with a higher oxygen concentration on the activated NiFe 2 O 4 and P-doped NiFe 2 O 4 nanoparticle surfaces (than that in bulk), which improves the charge transfer kinetics toward OER. Such surface species are not formed on Ni 1.5 Fe 1.5 O 4 . Overall, this study provides a mechanistic understanding of the role of Fe, P, and Ni in forming active oxygen species in the Ni-based spinels toward OER.}, archive = {J_ADVS}, author = {Weikai Xiang and Sheila Hernandez and Pouya Hosseini and Fan Bai and Ulrich Hagemann and Markus Heidelmann and Tong Li}, doi = {10.1002/advs.202501967}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501967}, shortjournal = {Adv. Sci.}, title = {Unveiling surface species formed on ni-fe spinel oxides during the oxygen evolution reaction at the atomic scale}, volume = {12}, year = {2025}, }
• (2025). EccDNA-driven VPS41 amplification alleviates genotoxic stress via lysosomal KAI1 degradation. ADVS, 12(25), 2501934. (www)

  @article{ , abstract = {Genotoxic therapies such as ionizing radiation eliminate cancer cells by inducing extensive DNA damage but often cause normal tissue toxicity, including cutaneous injury. Extrachromosomal circular DNA (eccDNA) refers to circular DNA fragments outside the chromosomal context, with their formation and persistence linked to DNA damage repair and genomic instability. Despite growing recognition of eccDNA in oncogenesis, its role under genotoxic stress in normal tissues remains poorly understood. Here, eccDNA is profiled in irradiated rat skin using Circle-seq, identifying alterations in eccDNA number and composition. Specifically, radiation induced circle 17:44148731-48208624 , in which vacuolar protein sorting 41 homolog (VPS41) is the sole radiation-induced amplification gene by semiquantitative PCR and gel electrophoresis. The findings show that eccDNA or VPS41 overexpression reduces radiation-induced skin injury (RISI) in vitro and in vivo. Proteomic and interaction analyses identified metastasis suppressor kangai-1 (KAI1) as a VPS41-interacting partner. Notably, VPS41 overexpression promotes KAI1 lysosomal degradation, protecting against radiation-induced apoptotic cell death. Peptide array analysis pinpoints the VPS41-KAI1 interaction through the K263 residue, consistent with AlphaFold prediction. The findings uncover a novel mechanism in which radiation-induced eccDNA, specifically VPS41, mitigates skin injury by modulating KAI1 degradation. This study highlights the role of eccDNA in cellular defense, providing strategies to enhance tissue resilience to genotoxic stress.}, archive = {J_ADVS}, author = {Bin Shi and Ping Yang and Huaijin Qiao and Jinchen He and Bin Song and Hao Bai and Fengdi Jiang and Yining Zhang and Qian Li and Tao Yan and Wenlin Tu and Daojiang Yu and Shuyu Zhang}, doi = {10.1002/advs.202501934}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501934}, shortjournal = {Adv. Sci.}, title = {EccDNA-driven VPS41 amplification alleviates genotoxic stress via lysosomal KAI1 degradation}, volume = {12}, year = {2025}, }
• (2025). HDAC6 and USP9X control glutamine metabolism by stabilizing GS to promote glioblastoma tumorigenesis. ADVS, 12(25), 2501553. (www)

  @article{ , abstract = {Glioblastoma (GBM) is the most common and the deadliest brain cancer. Glutamine anabolism mediated by glutamine synthetase (GS) is beneficial for GBM cell growth, especially under glutamine deprivation. However, the molecular mechanism underlying GS homeostasis in GBM remains undisclosed. Here, it is reported that histone deacetylase 6 (HDAC6) promotes GS deacetylation, stabilizing it via ubiquitin-mediated pathway. It is found that deubiquitination of GS is modulated by ubiquitin-specific peptidase 9, X-linked (USP9X). USP9X stabilizes GS by removing its K48-linked polyubiquitination on lysine 91 and 103. Accordingly, targeting HDAC6 and USP9X in vitro and in vivo represses GBM tumorigenesis by decreasing GS stability. Metabolic analysis shows that silencing HDAC6 and USP9X disrupts de novo nucleotide synthesis, thereby attenuating GBM cell growth. Furthermore, GS modulation by targeting HDAC6 and USP9X restrains the self-renewal capacity. These results suggest that HDAC6 and USP9X are crucial epigenetic enzymes that promote GBM tumorigenesis by modulating glutamine metabolism.}, archive = {J_ADVS}, author = {Go Woon Kim and Minhae Cha and Hien Thi My Ong and Jung Yoo and Yu Hyun Jeon and Sang Wu Lee and Soo Yeon Oh and Min-Jung Kang and Youngsoo Kim and So Hee Kwon}, doi = {10.1002/advs.202501553}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501553}, shortjournal = {Adv. Sci.}, title = {HDAC6 and USP9X control glutamine metabolism by stabilizing GS to promote glioblastoma tumorigenesis}, volume = {12}, year = {2025}, }
• (2025). Ambient air deposition allows reaching record light use efficiency in FAPbI3 perovskite solar cells. ADVS, 12(25), 2501533. (www)

  @article{ , abstract = {Semi-transparent solar cells represent an exciting opportunity for sustainable energy production, thanks to the possibility of being integrated into buildings and urban environments, effectively exploiting the already existing space. Perovskite solar cells (PCSs) are ideal candidates, offering high power conversion efficiencies (PCEs) combined with a tuneable band gap and adjustable thickness, which allow a convenient modulation of the average visible transmittance (AVT). However, balancing high PCE and high AVT is a challenging target. This study uncovers that depositing the perovskite layer based on Formamidinium Lead Iodide (FAPbI 3 ) thin films in ambient air, rather than in a nitrogen-controlled atmosphere, allows an increase in the AVT value of up to > 40% while also enhancing the photovoltaic performance and stability. The optoelectronic quality of the as-obtained perovskite layer is substantially enhanced, showing fewer defects and a superior morphology. As a result, the air-deposited devices exhibit higher efficiency, which, combines with the enhanced AVT, results in a champion device with a light use efficiency (LUE) of 4.2%, having a PCE of 13.8% and AVT of 30.4%. The record LUE value and the possibility of being deposited in ambient air conditions pave the avenue toward the real-world application of semi-transparent PSCs.}, archive = {J_ADVS}, author = {Nadir Vanni and Mario Calora and Lucia Mercurio and Antonella Giuri and Anna Paola Caricato and Veronica Chierchia and Claudio Carati and Riccardo Po' and Paolo Biagini and Salvatore Valastro and Emanuele Smecca and Giovanni Mannino and Alessandra Alberti and Aurora Rizzo}, doi = {10.1002/advs.202501533}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501533}, shortjournal = {Adv. Sci.}, title = {Ambient air deposition allows reaching record light use efficiency in FAPbI3 perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). The MdHB7L–MdICE1L–MdHOS1 module fine-tunes apple cold response via CBF-dependent and CBF-independent pathways. ADVS, 12(25), 2501524. (www)

  @article{ , abstract = {Cold stress is a major environmental factor limiting crop yield, quality, and geographical distribution worldwide. The homeodomain-leucine zipper (HD-Zip) transcription factor (TF) family plays a role in regulating plant abiotic stress responses, but the underlying mechanisms remain unclear. A HD-Zip TF, MdHB7L, is identified as promoting cold tolerance in apple. MdHB7L interacts with MdICE1L, enhancing its transcriptional activation of MdCBFs, and directly binds to MdCBF promoters to activate their expression. Conversely, MdICE1L inhibits the direct binding of MdHB7L on MdCBF promoters, revealing that MdHB7L acts as a cofactor rather than a TF when interacting with MdICE1L. Using ChIP-seq and RNA-seq, MdHB7L is found to directly regulate the expression of several key genes involved in ROS scavenging and biosynthesis of anthocyanins, soluble sugars, and proline, thereby enhancing apple cold tolerance. The E3 ubiquitin ligase MdHOS1 negatively regulates cold tolerance by interacting with and mediating the degradation of MdHB7L and MdICE1L, with a preference for MdICE1L over MdHB7L. This preference inhibits the MdHOS1–MdHB7L interaction and stabilizes MdHB7L, allowing it to sustain the plant's cold response as a TF after MdICE1L degradation. These findings provide new insights into the dynamic plant response to cold stress mediated by the MdHB7L–MdICE1–MdHOS1 module.}, archive = {J_ADVS}, author = {Jie Yang and Na Li and Ming Li and Ran Yi and Lina Qiu and Kangning Wang and Shuang Zhao and Fengwang Ma and Ke Mao}, doi = {10.1002/advs.202501524}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501524}, shortjournal = {Adv. Sci.}, title = {The MdHB7L–MdICE1L–MdHOS1 module fine-tunes apple cold response via CBF-dependent and CBF-independent pathways}, volume = {12}, year = {2025}, }
• (2025). Bacterial capture-killing capsules with remodeling bone immune microenvironment for the effective treatment of osteomyelitis. ADVS, 12(25), 2501505. (www)

  @article{ , abstract = {Osteomyelitis represents a significant health concern, characterized by a bacterial infection that can potentially present a considerable challenge to clinical treatment. Current treatment strategies, including prolonged antibiotic regimens and surgical debridement, often fail to adequately resolve infection or support bone regeneration, largely due to the pathogen-induced dysregulation of the bone microenvironment. This study reports a multifunctional capsule that achieves coordinated bacterial capture-killing and immunomodulatory within osseous tissue, effectively resolving the dual pathological challenges of persistent infection microenvironment and dysregulated bone regeneration inherent to osteomyelitis. The capsules, PC-O@TOB, are based on the Schiff base reaction of procyanidins (PC) with the amino of Lysine6-osteogenic growth peptide (K6-OGP) and tobramycin (TOB), which allows for efficient loading and controllable release of K6-OGP and TOB. In vitro and in vivo studies demonstrated that PC-O@TOB exhibits dual functionality: potent bactericidal activity through bacterial capture and localized antibiotic delivery, and microenvironmental remodeling via ROS scavenging and M2 macrophage polarization. This immunomodulatory effect synergizes with the capsule's osteogenic and angiogenic properties to accelerate bone repair. The strategy based on antibacterial and later bone microenvironment remodeling has opened up a new way for the treatment of osteomyelitis.}, archive = {J_ADVS}, author = {Dong Yang and Chang Shu and Chengwei Xu and Xingjie Zan and Shaoyin Wei and Chenglong Wang and Lianxin Li}, doi = {10.1002/advs.202501505}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501505}, shortjournal = {Adv. Sci.}, title = {Bacterial capture-killing capsules with remodeling bone immune microenvironment for the effective treatment of osteomyelitis}, volume = {12}, year = {2025}, }
• (2025). Contrast agent clearance dynamics and diffusion in the mouse brain after ventricular administration. ADVS, 12(25), 2501502. (www)

  @article{ , abstract = {Fluid and solute exchange between cerebrospinal fluid (CSF) spaces and the central nervous system (CNS) parenchyma are critical for maintaining neural homeostasis and clearing metabolites. Nevertheless, the pathways and mechanisms underlying fluid and solute exchange between these compartments remain poorly understood. Historically, solute exchange between CSF spaces and the CNS parenchyma has been attributed to diffusion primarily driven by concentration gradients. Recently, the glymphatic hypothesis has challenged this concept by proposing that fluid and solutes move through the brain parenchyma via bulk flow, with influx along arterial perivascular spaces (PVS) and efflux along venous PVS. In this study, we used dynamic contrast-enhanced MRI to investigate the distribution of two different contrast agents of molecular weights <1 kDa and 17 kDa injected into the lateral ventricle under awake, low-dose, and high-dose anesthesia conditions. Our findings revealed an increased CSF bulk flow of both contrast agents from the lateral ventricles to the circle of Willis under awake and low-dose anesthesia states. In contrast, solute movement into different regions of the brain parenchyma was size-dependent and affected by the rate of clearance from the ventricles. These observations support the CSF sink hypothesis, emphasizing diffusion-driven solute exchange as a key mechanism over glymphatic circulation.}, archive = {J_ADVS}, author = {Yann Decker and Andreas Müller and Steven T. Proulx}, doi = {10.1002/advs.202501502}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501502}, shortjournal = {Adv. Sci.}, title = {Contrast agent clearance dynamics and diffusion in the mouse brain after ventricular administration}, volume = {12}, year = {2025}, }
• (2025). Diurnal release of airborne pathogen spores in greenhouses via the synergistic effects of relative humidity and wind. ADVS, 12(25), 2501500. (www)

  @article{ , abstract = {The occurrence of diseases during greenhouse vegetable cultivation is becoming increasingly severe. Humidity and wind are important factors affecting the spread of many pathogenic fungal spores, but it remains difficult to explain the phenomenon of rapid spore spread in greenhouses. Here, the detachment of spores from hyphae during rapid drops in humidity and their subsequent dispersal due to wind is detailed. It is demonstrated that Corynespora cassiicola spores exhibit jerking movements during humidity reduction, resulting in spore discharge, and that spore connections are weaker in high-humidity environments than in low-humidity environments. This investigation across the fungal kingdom further reveals that jerking movements are common in the tested hyphomycete spore species. Spores rely mainly on wind to spread after being discharged from hyphae, and their spread range is influenced by factors such as wind speed, spore source height, and spore age. In summary, it is discovered that the combined effects of diurnal humidity fluctuations and wind drive the rapid spread of pathogenic spores in greenhouses, providing a theoretical basis for optimizing control strategies for airborne fungal diseases in greenhouses.}, archive = {J_ADVS}, author = {Jiayi Ma and Ali Chai and Yanxia Shi and Xuewen Xie and Lei Li and Sheng Xiang and Xianhua Sun and Tengfei Fan and Baoju Li}, doi = {10.1002/advs.202501500}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501500}, shortjournal = {Adv. Sci.}, title = {Diurnal release of airborne pathogen spores in greenhouses via the synergistic effects of relative humidity and wind}, volume = {12}, year = {2025}, }
• (2025). Elastic fiber programming for simplified pneumatic control in soft robots. ADVS, 12(25), 2501477. (www)

  @article{ , abstract = {Conventional pneumatic soft robots require complex control systems with multiple valves and circuits due to coupled structural and pneumatic dynamics. A strategy is presented to program the pneumatic response characteristics of soft actuators by embedding elastic fibers with tailored materials and pre-stretch ratios, enabling structurally identical modules to exhibit distinct pressure-driven responses. A 6 mm-diameter actuator prototype demonstrates this paradigm, achieving a 2632% load ratio and 225°/s bending speed at a material cost of 9 cents. Crucially, a single pneumatic input suffices for multi-step actuation—shown in pipeline-climbing robots, omnidirectional crawlers, and grippers adapting to objects from 10 to 450 g. This fusion of material programming and mechanical intelligence simplifies control architectures while enhancing functionality, offering a scalable path toward deployable soft robotics.}, archive = {J_ADVS}, author = {Xiaoli Yang and Tao Jin and Shiwei Tian and Jieyu Wang and Sicheng Yi and Yue Wang and Long Li and Yangqiao Lin}, doi = {10.1002/advs.202501477}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501477}, shortjournal = {Adv. Sci.}, title = {Elastic fiber programming for simplified pneumatic control in soft robots}, volume = {12}, year = {2025}, }
• (2025). A universal toughening and energy-dissipating strategy for impact-resistant 3D-printed composites. ADVS, 12(25), 2501450. (www)

  @article{ , abstract = {3D-printed polymer-based composites are promising for various engineering applications due to high strength-to-weight ratios and design flexibility. However, conventional matrix materials, such as polylactic acid and epoxy resin, often exhibit brittleness and limited impact resistance (< 10 kJ m − 2 ). Herein, a universal strategy is reported for enhancing the ductility and impact energy absorption of 3D-printed composites by leveraging the dynamic crosslinking of B─O dative bonds. To validate its effectiveness, a smart composite (PLA/SSG) comprising shear-stiffening gel fillers embedded in a polylactic acid matrix is designed and its rate-dependent mechanical adjustability along with 3D printability is evaluated. The resulting composite shows significant improvements in impact resistance, ductility, and strength-ductility balance. Specifically, the multiple crack and localized plastic yielding of polylactic acid matrix induced by shear-stiffening gel fillers enables PLA/SSG with a 40-times increase in ductility; the “soft-hard” phase transition of shear-stiffening gel induced by B─O bonds endows PLA/SSG with a 330% improvement in impact energy absorption. This B─O bonds-inspired strategy provides a universal approach for printing smart impact-resistant composites and structures.}, archive = {J_ADVS}, author = {Xiang Hong and Peng Wang and Yu Ma and Weidong Yang and Junming Zhang and Zhongsen Zhang and Yan Li}, doi = {10.1002/advs.202501450}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501450}, shortjournal = {Adv. Sci.}, title = {A universal toughening and energy-dissipating strategy for impact-resistant 3D-printed composites}, volume = {12}, year = {2025}, }
• (2025). Comprehensive study of li deposition and solid electrolyte cracking by integrating simulation and experimental data. ADVS, 12(25), 2501434. (www)

  @article{ , abstract = {Lithium (Li) penetration into solid-state electrolytes (SE) is a major cause of lithium-metal solid-state battery (LMSSB) failure. However, no single model fully explains experimental phenomena, and many simulation-based conclusions lack validation or contradict experimental results, hindering the understanding of failure mechanisms. This study integrates simulation and experimental data to investigate Li deposition and SE cracking, introducing a unified phase-field (PF) model. Unlike existing models, it accounts for mechanical constraints, solid–solid contact, and large-strain mechano-chemical coupling. It also distinguishes Li penetration from SE cracking, as short-circuiting and cracking do not occur simultaneously. Additionally, crack initiation follows the pressurized cracking model, while propagation occurs through a wedge-shaped opening. A counterintuitive approach to extending LMSSB lifespan is to reduce the mechanical constraints of SE rather than decreasing defect size or increasing SE hardness and toughness, provided that good contact is maintained between the electrode and SE. This is because minimizing mechanical constraints alters the Li deposition mode, preventing rapid Li eruption in cracks.}, archive = {J_ADVS}, author = {Chen Lin and Haihui Ruan and Ming-Sheng Wang}, doi = {10.1002/advs.202501434}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501434}, shortjournal = {Adv. Sci.}, title = {Comprehensive study of li deposition and solid electrolyte cracking by integrating simulation and experimental data}, volume = {12}, year = {2025}, }
• (2025). Rough and tough: How particle surface roughness affects liquid marble formation and stability. ADVS, 12(25), 2501378. (www)

  @article{ , abstract = {Liquid marbles are liquid droplets encased by non-wetting particles. They exhibit elastic and non-sticking properties that enable applications such as sensors, adhesives, miniature reactors, and material carriers. The formation, stability, and properties of liquid marbles depend on the physico-chemical characteristics of the solid particles. This study systematically explores the impact of particle surface roughness on liquid marbles by employing colloidal supraparticles as well-defined model systems. Supraparticles are spherical aggregates of uniform colloidal primary particles, which enable adjusting the characteristic surface roughness by varying the primary particle size. Increasing surface roughness increases the interfacial contact angle, which, in turn, influences the mechanical properties and liquid marble stability. The presence of surface roughness increases the deformation resistance of the liquid marble, which counteracts the spreading of the inner liquid upon mechanical impact, and therefore hinders rupture. The increased contact angle further enables the formation of liquid marbles from increasingly low-surface-tension organic liquids. This study thus provides detailed insights into the structure-property relationships governing the preparation of stable liquid marbles based on particle surface characteristics.}, archive = {J_ADVS}, author = {Umair Sultan and Celin Kotulla and Kall Kefle and Syuji Fujii and Nicolas Vogel}, doi = {10.1002/advs.202501378}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501378}, shortjournal = {Adv. Sci.}, title = {Rough and tough: How particle surface roughness affects liquid marble formation and stability}, volume = {12}, year = {2025}, }
• (2025). Non-respiratory extracellular electron transfer competes with nitrogenase for electrons in rhodopseudomonas palustris. ADVS, 12(25), 2501376. (www)

  @article{ , abstract = {Biological nitrogen fixation (BNF) is a pivotal process that reduces nitrogen to ammonium within the nitrogen cycle. Extracellular electron transfer (EET) between diazotrophs and the extracellular environment influences the occurrence and efficiency of BNF. Although extracellular electron acceptors can function as a component of the electron transport chain, providing energy for chemotrophic nitrogen fixation via extracellular respiration, the function and mechanism of outward EET in photosynthetic diazotrophs remain unclear. Here, using Rhodopseudomonas palustris TIE-1, a photosynthetic bioelectrochemical nitrogen fixation system is established for simultaneous nitrogen fixation and current generation, to dissect the complex interaction between these two processes. Outward EET functions are found to maintain redox balance, rather than serving as an extracellular respiration pathway. It significantly suppresses BNF by competing with nitrogenase for electrons. Lumichrome serves as the primary electron shuttle for indirect electron transfer, while cytochromes play an important role in direct electron transfer. Notably, the pio operon participates in outward EET. This study reveals the interaction mechanism between photosynthetic BNF and outward EET, providing new insight into the regulatory mechanisms of nitrogen fixation in anoxygenic phototrophs across diverse environmental conditions.}, archive = {J_ADVS}, author = {Xuewen Liu and Panqing Qi and Weipeng Fan and Wuyang Liu and Xingjiang Li and Yong Nie and Xiao-Lei Wu}, doi = {10.1002/advs.202501376}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501376}, shortjournal = {Adv. Sci.}, title = {Non-respiratory extracellular electron transfer competes with nitrogenase for electrons in rhodopseudomonas palustris}, volume = {12}, year = {2025}, }
• (2025). In situ converting conformal sacrificial layer into robust interphase stabilizes fluorinated polyanionic cathodes for aqueous sodium-ion storage. ADVS, 12(25), 2501362. (www)

  @article{ , abstract = {Sodium vanadium oxy-fluorophosphates (NVOPF), as typical fluorinated polyanionic compounds, are considered high-voltage and high-capacity cathode materials for aqueous sodium-ion storage. However, the poor cycle life caused by interfacial degradation (especially the attack of specific HF by-products) greatly hampers their application in aqueous electrolytes. Here, it is shown that in situ converting harmful HF derivate to F-containing cathode electrolyte interphase (CEI) can overcome the above challenge. As a proof-of-concept, a conformal Al 2 O 3 sacrificial layer is precoated on NVOPF for on-site generating robust AlF 3 -rich CEI while eliminating continuous HF release. The evolved CEI chemistry mitigates interfacial side reactions, inhibits vanadium dissolution, and promotes Na + transport kinetics, thus significantly boosting cycling stability (capacity retention rate increased to 3.15 times), rate capability, and even low-temperature performance (≈1.5 times capacity improvement at −20 °C). When integrated with pseudocapacitive zeolite-templated carbon anode and adhesive hydrogel electrolyte, a unique 2.3 V quasi-solid-state sodium-ion hybrid capacitor is developed, exhibiting remarkable cycle life (77.0% after 1000 cycles), high energy and power densities, and exceptional safety against extreme conditions. Furthermore, a photovoltaic energy storage module is demonstrated, highlighting the potential use in future smart/microgrids. The work paves new avenues for enabling the use of unstable electrode materials via interfacial engineering.}, archive = {J_ADVS}, author = {Peng Gong and Shibo Chai and Xingjie Li and Yibo Dong and Shengjun Zhai and Xihao Chen and Ning Wang and Yuanyuan Li and Jinping Liu}, doi = {10.1002/advs.202501362}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501362}, shortjournal = {Adv. Sci.}, title = {In situ converting conformal sacrificial layer into robust interphase stabilizes fluorinated polyanionic cathodes for aqueous sodium-ion storage}, volume = {12}, year = {2025}, }
• (2025). Polyaspartic acid-calcium-lanthanum complexes induce antibacterial remineralization of dentin and in-depth occlusion of dentinal tubules. ADVS, 12(25), 2501340. (www)

  @article{ , abstract = {Dental caries is a global oral dilemma leading to demineralization of tooth hard tissues and exposure of dentinal tubules (DTs). Multifunctional restorative strategies, including remineralization, antibacterial properties, and DT occlusion, are urgently needed for dental caries management but remain a significant challenge. Herein, the polyaspartic acid-calcium-lanthanum suspension (5 g L −1 -3.06 м-0.34 м) followed by phosphate solution (2.04 м) is adopted to conduct polyelectrolyte-cation complexes pre-precursor process. This strategy, for the first time, successfully induces La-doped intrafibrillar mineralization of collagen fibrils with lanthanum-doped hydroxyapatite (La-HAp). After sequential application of two mineralization media, the demineralized dentin is fully remineralized and the DTs are deeply occluded to a depth of 100 µm with La-HAp after 7 d of incubation in artificial saliva or oral cavity of rabbit. The remineralized dentin demonstrates antibacterial properties against cariogenic bacteria ( Streptococcus mutans ) both in vitro and in vivo, and its mechanical properties are almost restored to those of intact dentin. The mineralization media cause no apparent irritation to oral mucosa or dental pulp. Hence, this multifunctional strategy confers the remineralized dentin surface with antibacterial properties and blocks the invasion of cariogenic bacteria through DTs, providing insight into the clinical management of dentin caries accompanied by dentin hypersensitivity.}, archive = {J_ADVS}, author = {Ling Zhu and Wei Liu and Yizhou Zhang and Zhifang Wu and Yiru Wang and Yuedan Xu and Haiyan Zheng and Hongli Zhang and Mengfei Yu and Xiaoting Jin and Zhe Wang and Zihuai Zhou and Baiping Fu}, doi = {10.1002/advs.202501340}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501340}, shortjournal = {Adv. Sci.}, title = {Polyaspartic acid-calcium-lanthanum complexes induce antibacterial remineralization of dentin and in-depth occlusion of dentinal tubules}, volume = {12}, year = {2025}, }
• (2025). Proteomics-empowered microfluidic-SERS immunoassay for identifying and detecting biomarkers of micropapillary lung adenocarcinoma. ADVS, 12(25), 2501336. (www)

  @article{ , abstract = {The presence of a micropapillary (MPP) component is a crucial determinant of surgical strategies for lung adenocarcinoma (LUAD), yet reliable blood biomarkers for predicting MPP⁺ LUAD remain elusive. Here, we integrate 4D label-free quantitative proteomics, a nanomixing-enhanced microfluidic surface-enhanced Raman spectroscopy (SERS) platform, and machine learning to sensitively identify and validate blood protein biomarkers associated with MPP⁺ LUAD. Comparative proteomics reveal 44 differentially expressed proteins (DEPs) between MPP⁺ and MPP⁻ LUADs, with bioinformatics uncovering their roles in MPP⁺ LUAD formation. To enable sensitive, multiplex detection of 4 upregulated DEPs, the nanomixing effect is leveraged to enhance target protein-SERS barcode interactions while minimizing nonspecific binding to antibody-functionalized gold electrodes. The SERS barcode cocktail allows simultaneous detection of the 4 selected DEPs. Machine learning models based on SERS detection effectively distinguish MPP⁺ from MPP⁻ LUAD patients, as well as LUAD patients from healthy donors. This approach demonstrates strong diagnostic potential for early, non-invasive MPP detection in LUAD, advancing nanotechnology-driven disease diagnosis and monitoring.}, archive = {J_ADVS}, author = {Dechun Zhang and Kaiming Peng and Hui Xu and Yanping Chen and Jing Wang}, doi = {10.1002/advs.202501336}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501336}, shortjournal = {Adv. Sci.}, title = {Proteomics-empowered microfluidic-SERS immunoassay for identifying and detecting biomarkers of micropapillary lung adenocarcinoma}, volume = {12}, year = {2025}, }
• (2025). Sinter- and water-resistant pt enabled by high entropy of porous oxide nanofibers. ADVS, 12(25), 2501334. (www)

  @article{ , abstract = {Supported ultrafine noble metal species, especially for Pt, suffer from inevitable sintering at temperatures as low as 80 °C, severely limiting their stability and thus their practical applications. In this work, a strategy is demonstrated using the high-entropy effect to prevent sub-2.6 nm Pt nanoparticles from sintering. Due to the higher mixing entropy and thus lower Gibbs free energy of porous high-entropy oxide (HEO) nanofibers in the catalytic system, the supported Pt remained thermally stable up to 1000 °C, as verified by in situ HAADF−STEM observation. Even after being hydrothermally aged with 10 vol% vapor at 850 °C, this catalytic system maintained the Pt size of 2.9 nm, demonstrating remarkable sinter-resistance and water tolerance. Particularly, after aging at 850 °C, the Pt/HEO catalytic system maintained its full CO conversion for 338 h without any decline. These results highlight the positive effect of increasing configurational entropy on the thermal stability of the entire catalytic system, providing a reliable solution for catalytic conversions involving high temperatures.}, archive = {J_ADVS}, author = {Yunpeng Wang and Mingyu Tang and Zhuxin Lyu and Wanlin Fu and Han Yan and Shiming Zhou and Yueming Sun and Yunqian Dai}, doi = {10.1002/advs.202501334}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501334}, shortjournal = {Adv. Sci.}, title = {Sinter- and water-resistant pt enabled by high entropy of porous oxide nanofibers}, volume = {12}, year = {2025}, }
• (2025). Turning microstructure in block copolymer membranes: A facile strategy to improve CO2 separation performance. ADVS, 12(25), 2501330. (www)

  @article{ , abstract = {To mitigate global climate change, the development of membranes with high CO 2 permeability and selectivity is urgently needed. Here, a simple and effective non-solvent-induced microstructure rearrangement (MSR) technique is proposed to enhance the gas separation performance of Pebax 2533 membranes. By immersing Pebax 2533 membranes in amino acid salt solutions to induce MSR, the CO 2 permeability of the optimized Pebax 2533-GlyK 10 wt.% membrane reached 1180 Barrer, a 4.5-fold increase compared to the original membrane, without compromising CO 2 /N 2 selectivity. Moreover, the MSR membrane maintains stable gas separation performance for nearly 500 days, demonstrating excellent long-term stability. Furthermore, applying the MSR technique to thin-film composite (TFC) membranes revealed that both Pebax 2533/polyvinyl chloride (PVC) hollow fiber (HF) TFC membranes and Pebax 2533/polyacrylonitrile (PAN) flat-sheet TFC membranes exhibited significantly enhanced CO 2 permeance under the treatment of DI water. Characterization results indicated that the chemical-physical properties of the membranes before and after MSR are nearly unchanged, suggesting that the non-solvent-induced MSR is a promising technique for next-generation membrane development for carbon capture.}, archive = {J_ADVS}, author = {Jing Wei and Min Deng and Zikang Qin and Weiyi Zhao and Yujie Li and Roman Selyanchyn and Hongyong Zhao and Jie Dong and Dengguo Yin and Yuanfa Zhuang and Liyuan Deng and Lin Yang and Lu Yao and Wenju Jiang and Junfeng Zheng and Bart Van der Bruggen and Zhongde Dai}, doi = {10.1002/advs.202501330}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501330}, shortjournal = {Adv. Sci.}, title = {Turning microstructure in block copolymer membranes: A facile strategy to improve CO2 separation performance}, volume = {12}, year = {2025}, }
• (2025). Constructing polymetallic nodes in Metal–Organic frameworks enhance antibacterial of drug-resistant bacteria. ADVS, 12(25), 2501327. (www)

  @article{ , abstract = {The misuse of antibiotics results in the emergence of a large number of drug-resistant bacteria, which leads to huge financial and social burdens. Exploring artificial nanozymes is regarded as a promising candidates for the substitution of antibiotics, but still remain a huge challenge. Herein, a new strategy is reported for constructing polymetallic indium coordination node Metal-organic frameworks (MOFs) (polyIn-BTB) for enhancing the production of reactive oxygen species (ROS), which significantly promote antibacterial activity. Theoretical research reveals that, compared to monometallic indium coordination node MOFs (monoIn-BTB), polyIn-BTB exhibits a stronger electron-donating ability, which can facilitate the efficient production of ROS. Thus, polyIn-BTB shows outstanding antibacterial properties of 87.0% and 92.0% for Methicillin-Resistant Staphylococcus aureus ( MRS. aureus ) and Escherichia coli ( E. coli ) respectively, which is significantly higher than that of monoIn-BTB (42% for MRS. Aureus and 50% for E. coli ). The in vivo experiments demonstrate that polyIn-BTB accelerates wound healing by killing bacteria and inhibiting the inflammatory response they cause, with a wound healing rate of 98.0% in 8 days. Overall, this work reports a new strategy for constructing polyIn-BTB for enhancing the antibacterial performance, which opens the door to fundamental research on designing the nanozyme with high performance.}, archive = {J_ADVS}, author = {Qinqin Li and Shihan Zhang and Yachao Xu and Yaru Guo and Youxing Liu}, doi = {10.1002/advs.202501327}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501327}, shortjournal = {Adv. Sci.}, title = {Constructing polymetallic nodes in Metal–Organic frameworks enhance antibacterial of drug-resistant bacteria}, volume = {12}, year = {2025}, }
• (2025). Radical-polar crossover bicyclization enables a modular synthesis of saturated bicyclic amines. ADVS, 12(25), 2501310. (www)

  @article{ , abstract = {The rapid assembly of diverse cyclic amines from simple precursors is now considered as an ideal platform with respect to efficiency and sustainability. To date, numerous synthetic methods have been successfully developed however, most of them are limited to a narrow subset of cyclic amines, with variations in ring size often requiring different substrates and distinct synthetic strategies. Furthermore, the “escape-from-Flatland” concept has led chemists to focus on the synthesis of C(sp 3 )-rich small molecules for potential drug candidates. Herein, the successful realization of a radical-polar crossover bicyclization reaction is reported from easily available cyclopropylamines and substituted alkenes through photoredox catalysis. This approach introduces an innovative methodology for the de novo synthesis of a diverse collection of 4/5-, 5/5-, 6/5-,7/5-, and 5/6-fused saturated bicyclic amines in a systematic and modular manner with excellent diastereoselectivity. This work highlights the efficiency and utility of the photoinduced radical–polar crossover bicyclization, the applicability of which is showcased by excellent functional group tolerance, wide substrate scopes, and simple derivatization reactions.}, archive = {J_ADVS}, author = {Dewei Feng and Xiao Geng and Lingling Zuo and Zhifang Li and Lei Wang}, doi = {10.1002/advs.202501310}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501310}, shortjournal = {Adv. Sci.}, title = {Radical-polar crossover bicyclization enables a modular synthesis of saturated bicyclic amines}, volume = {12}, year = {2025}, }
• (2025). Unlocking methane generation via photo-thermal-coupled CO2 hydrogenation by integrating FeNiCrMnCo multicomponent alloy with GaN nanowires. ADVS, 12(25), 2501298. (www)

  @article{ , abstract = {The exploration of a noble-metal-free photo-thermal-coupled catalytic architecture plays a vital role in solar-driven conversion of carbon dioxide (CO 2 ) into high-value fuels and chemicals. In this study, FeNiCrMnCo multicomponent alloy (MCA) is integrated with GaN nanowires (NW's) for photo-thermal-coupled catalytic CO 2 methanation. The MCA/GaN NW's nanohybrid demonstrates a considerable methane production rate of 199 mmol∙g −1 ∙h −1 with an impressive selectivity of 93% under white light irradiation of 3 W∙cm −2 at 290 °C by external heating. The turnover number approaches 20,160 mole CH 4 per mole of MCA over a continuous operation period of 120 h, showcasing remarkable stability. Mechanistic investigations reveal that the unique MCA provides a flexible platform for tailoring the electronic and catalytic properties to optimize the adsorption and activation of CO₂ and H₂, thus leading to efficient and selective CO₂ methanation. This study presents an industry-friendly architecture for photo-thermal-coupled CO 2 hydrogenation into high-value fuels and chemicals by coupling a noble-metal-free multicomponent alloy with GaN NWs, paving the way for advancements in sustainable energy conversion through CO 2 utilization.}, archive = {J_ADVS}, author = {Muhammad Salman Nasir and Ying Zhao and Haotian Ye and Jinglin Li and Ping Wang and Ding Wang and Xinqiang Wang and Jun Song and Zhen Huang and Baowen Zhou}, doi = {10.1002/advs.202501298}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501298}, shortjournal = {Adv. Sci.}, title = {Unlocking methane generation via photo-thermal-coupled CO2 hydrogenation by integrating FeNiCrMnCo multicomponent alloy with GaN nanowires}, volume = {12}, year = {2025}, }
• (2025). High-gain PMMA-modified graphene photodetectors for dual-wavelength secure communication utilizing distinct temporal photoresponses. ADVS, 12(25), 2501294. (www)

  @article{ , abstract = {Photodetectors exhibiting oppositive polar responses at two different wavelengths have been used extensively for secure optical communication. However, current technologies are susceptible to signal cancellation and cross-talk, due to the time-independent responses of equal strengths. In this study, a different encryption system based on a PMMA-modified graphene (PMG) photodetector is demonstrated that shows remarkable wavelength-dependent temporal responses: the PMG detector shows a largely constant response for wavelengths longer than 580 nm, while a linear time dependence for shorter wavelengths. It is found that the qualitatively different temporal responses are attributed to the photogating effects and the PMMA-mediated oxygen desorption process, respectively. Moreover, the PMG device achieves exceptionally large normalized-gain values of 2.18 × 10 −3 m 2 V −1 and 2.97 × 10 −‍5 ‍m 2 V −‍1 for the two cases, respectively, both surpassing previously reported values by an order of magnitude for the bipolar responsive photodetectors in ambient conditions. By harnessing these distinct temporal photoresponses as encrypted and key signals at different wavelengths, an effective encryption system for optical communication is demonstrated that enhances signal recovery and avoids signal cancellation. The research introduces a straightforward yet efficient structural design for photodetectors with temporally distinct photoresponses at specific wavelengths and represents a significant advancement in the field of secure communication.}, archive = {J_ADVS}, author = {Jinhua Wu and Hao Sun and Ruiling Zhang and Shipeng Yao and Zhangyu Hou and Cun-Zheng Ning}, doi = {10.1002/advs.202501294}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501294}, shortjournal = {Adv. Sci.}, title = {High-gain PMMA-modified graphene photodetectors for dual-wavelength secure communication utilizing distinct temporal photoresponses}, volume = {12}, year = {2025}, }
• (2025). Artificial olfactory system enabled by ultralow chemical sensing variations of 1D SnO2 nanoarchitectures. ADVS, 12(25), 2501293. (www)

  @article{ , abstract = {AI-assisted electronic nose systems often emphasize sensitivity-driven datasets, overlooking the comprehensive analysis of gaseous chemical attributes critical for precise gas identification. Conventional fabrication methods generate inconsistent datasets and focus primarily on improving classification accuracy through deep learning, neglecting the fundamental role of sensor material design. This study addresses these challenges by developing a highly reliable sensor platform to standardize gas sensing for deep learning applications. Specifically, 1D SnO 2 nanonetworks functionalized with Au and Pd nanocatalysts are fabricated via a systematic deposition process, enhancing gas diffusion and reaction kinetics. Stability improvements through controlled aging process reduce the coefficient of variation to below 5% across seven target gases: acetone, hydrogen, ethanol, carbon monoxide, propane, isoprene, and toluene. The platform exhibits exceptional deep learning performance, achieving over 99.5% classification accuracy using a residual network model, even in high-humidity environments (up to 80% relative humidity) and at parts-per-trillion detection limits. This study highlights the synergy between nanostructure engineering and AI, establishing a robust framework for next-generation bioinspired electronic nose systems with enhanced reliability and analytical capability.}, archive = {J_ADVS}, author = {Yun-Haeng Cho and Dong-Su Kim and Jung Hwan Seo and Jae Han Chung and Zion Park and Ki Chang Kwon and Jae-Kwon Ko and Tae Won Ha and Jeong-O Lee and Gyu-Li Kim and Seong-Jun Ro and Hyojung Kim and Chil-Hyoung Lee and Kwangjae Lee and Young-Seok Shim and Donghwi Cho}, doi = {10.1002/advs.202501293}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501293}, shortjournal = {Adv. Sci.}, title = {Artificial olfactory system enabled by ultralow chemical sensing variations of 1D SnO2 nanoarchitectures}, volume = {12}, year = {2025}, }
• (2025). Facilitating crRNA design by integrating DNA interaction features of CRISPR-cas12a system. ADVS, 12(25), 2501269. (www)

  @article{ , abstract = {The CRISPR-Cas12a system has gained significant attention as a rapid nucleic acid diagnostic tool due to its crRNA-guided trans -cleavage activity. Accurately predicting the activity of different targets is significant to facilitate the crRNA availability but remains challenging. In this study, a novel approach is presented that combines molecular dynamics simulations and neural network modeling to predict the trans -cleavage activity. Unlike conventional tools that rely solely on the base sequences, our method integrated sequence features and molecular interaction features of DNA in the CRISPR-Cas12a system, significantly improving prediction accuracy. Through feature importance analysis, key sequence features that influence Cas12a trans -cleavage activity are identified. Additionally, a crRNA-DNA library with over 23 456 feature sequences from representative viruses and bacteria is established, and validated the high predictive accuracy of the model (Pearson's r = 0.9328) by screening crRNAs from reference targets. This study offers new insights into the molecular interactions of Cas12a/crRNA-DNA and provides a reliable framework for optimizing crRNA design, facilitating the application of the CRISPR-Cas12a in rapid nucleic acid diagnostics.}, archive = {J_ADVS}, author = {Zhihao Yao and Wanglu Li and Kaiyu He and Hongmei Wang and Yan Xu and Qun Wu and Liu Wang and Yao Nie}, doi = {10.1002/advs.202501269}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501269}, shortjournal = {Adv. Sci.}, title = {Facilitating crRNA design by integrating DNA interaction features of CRISPR-cas12a system}, volume = {12}, year = {2025}, }
• (2025). Piezoresistive effect: A new concept for hearing aids. ADVS, 12(25), 2501227. (www)

  @article{ , abstract = {Hearing loss is among the most prevalent sensory impairments globally. Hearing aids assist individuals with hearing impairments in perceiving sound more effectively, serving as essential tools for reconnecting them with the world. Herein, an MXene/Polyvinyl Alcohol sound sensor (MPSS) capable of recognizing weak sound signals is developed. It can not only recognize different speech signals and sound properties but also show good stability in the process of long-term sound recording. In addition, by combining the sensor with machine learning, the accuracy rate of voiceprint recognition of wildlife conservation is up to 99%, underscoring its practical significance for wildlife protection. Utilizing piezoresistive effects, a hearing aid with a detection sound threshold of 60 dB and a frequency range of 20–4000 Hz is achieved, which provides a feasible scheme in hearing aids.}, archive = {J_ADVS}, author = {Mengyao Gao and Weijie Liu and Kun Chen and Huili Sun and Xiaoqing Liu and Haonan Xing and Huatang Wang and Benpeng Zhu and Haizhong Guo}, doi = {10.1002/advs.202501227}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501227}, shortjournal = {Adv. Sci.}, title = {Piezoresistive effect: A new concept for hearing aids}, volume = {12}, year = {2025}, }
• (2025). Sortilin-mediated rapid, precise and sustained degradation of membrane proteins via mRNA-encoded lysosome-targeting chimera. ADVS, 12(25), 2501222. (www)

  @article{ , abstract = {Recent advances in lysosome-targeting degradation technologies have introduced strategies to regulate therapeutic membrane proteins (MPs), potentially transforming treatment paradigms. However, challenges persist, including limited degradation precision due to the broad distribution of lysosome-targeting receptors (LTRs), as well as the high cost and complexity of recombinant protein production or chemical synthesis. Herein, it identifies sortilin as a promising LTR, highly expressed in malignancies but minimally present in healthy tissues outside the nervous system. Using AlphaFold-Multimer, it screened for a specific non-endogenous protein binder to sortilin and developed a modular, mRNA-encoded lysosomal targeting chimera (MedTAC) strategy, enabling rapid design and precise degradation of oncogenic MPs. In a breast cancer-bearing mouse model, a single low dose of MedTAC PTK7 (0.5 mg kg −1 ) reduced protein tyrosine kinase-7 (PTK7) levels by up to 80% within 24 h, with sustained degradation of 44% at 72 h, demonstrating excellent pharmacokinetics. MedTAC PTK7 significantly extended survival to over 50 days without systemic toxicity, compared to 20–30 days in controls. This MedTAC strategy establishes sortilin as a selective and efficient shuttle for targeted protein degradation, offering a scalable, rapidly producible platform for biochemical research and precise therapeutic applications.}, archive = {J_ADVS}, author = {Xin Chang and Xinyu Qiu and Xiaoning Tong and Shaoju Gan and Weicheng Yi and Sitao Xie and Xiangsheng Liu and Chao Zuo and Weihong Tan}, doi = {10.1002/advs.202501222}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501222}, shortjournal = {Adv. Sci.}, title = {Sortilin-mediated rapid, precise and sustained degradation of membrane proteins via mRNA-encoded lysosome-targeting chimera}, volume = {12}, year = {2025}, }
• (2025). Multivariate covalent organic frameworks for high-performance ammonia nitrogen separation: Structure-property-function relationships. ADVS, 12(25), 2501173. (www)

  @article{ , abstract = {Adsorption-based separation of cationic pollutants, typically ammonia nitrogen (NH 4 + −N), from water holds great potential for environmental decontamination and resource recycling. However, NH 4 + is more challenging to adsorb than other cations due to its stable structure and relatively large ionic radius. In this study, a “multivariate” synthetic strategy is applied to construct covalent channels through rational encoding sulfonic acid groups to enhance NH 4 + adsorption and to investigate the structure-property-function relationships of sulfonated covalent organic frameworks (COFs). The optimal sulfonic acid group density is 50%, with an adsorption capacity of 17.09 mg g −1 and an equilibrium time of 5 min, far surpassing most adsorbents. The crystallinity of COFs significantly enhances both adsorption capacity and kinetics. Surface area and hydrophilicity primarily increaseadsorption capacity, with minimal influence on kinetics. In contrast, a large pore size correlates negatively with adsorption capacity but facilitates kinetics. N K-edge near-edge X-ray absorption fine structure spectroscopy validates atomic-level adsorption mechanisms of ion exchange between NH 4 + and Na + at the -SO 3 Na site and the formation of hydrogen bonds (N─H─N and N─H─O) between H of NH 4 + and pyrrolic N as well as O of carbonyl on COFs. This study provides directions for designing ultrafast and high-capacity adsorbents for cation capture.}, archive = {J_ADVS}, author = {Yunhui Zhang and Jinglin Liu and Tao Wang and Kean Zhu and Yifan Gu and Zihao Wang and Meng Zhang and Zijian Xu and Zhenhua Chen and Haitao Li and Wei Jin}, doi = {10.1002/advs.202501173}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501173}, shortjournal = {Adv. Sci.}, title = {Multivariate covalent organic frameworks for high-performance ammonia nitrogen separation: Structure-property-function relationships}, volume = {12}, year = {2025}, }
• (2025). Tailored 3D lattice microstructures for enhanced functionality in blood-gas exchange. ADVS, 12(25), 2501162. (www)

  @article{ , abstract = {Current membrane oxygenators for extracorporeal life support (ECLS) are facing their limits regarding gas exchange efficiency and long-term stability. One aspect adding to these limitations is inhomogeneous blood flow distribution inside the oxygenator's membrane structure. Triply periodic minimal surface (TPMS) lattice structures are proposed to provide increased mass transfer efficiency and local adaptability introducing heterogeneous properties. However, the adaptation of these structures for blood flow, as in ECLS, is challenging as a hemocompatible flow distribution must be established. In this study, this study proposes a novel method for the smooth, multi-scale modification of TPMS lattice structures creating a tailored flow distribution suited for blood-gas exchange. It implements this method into an automatic structure optimization within an oxygenator. After manufacturing prototypes, it experimentally evaluate the 3D flow distribution using time-resolved, contrast enhanced computed tomography comparing the optimized structure to reference geometries. The TPMS structure modification provides a significant change in flow distribution, improving homogeneity by up to 12%. The approach to creating tailored 3D TPMS lattice structures can be directly transferred to various other applications in the field of heat and mass transfer to enhance functionality, e.g., for heat exchangers or membrane contactors.}, archive = {J_ADVS}, author = {Kai P. Barbian and Teresa Lemainque and Ina Grunden and Roman Iwa and Bettina Wiegmann and John Linkhorst and Matthias Wessling and Jan Heyer and Ulrich Steinseifer and Michael Neidlin and Sebastian V. Jansen}, doi = {10.1002/advs.202501162}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501162}, shortjournal = {Adv. Sci.}, title = {Tailored 3D lattice microstructures for enhanced functionality in blood-gas exchange}, volume = {12}, year = {2025}, }
• (2025). Polydopamine chelate modified separators for lithium metal batteries with high-rate capability and ultra-long cycling life. ADVS, 12(25), 2501155. (www)

  @article{ , abstract = {Lithium metal batteries (LMBs) have gained significant attention because of their high theoretical energy density. However, under high-rate charge and discharge conditions, lithium metal anodes are susceptible to dendrite formation, compromising battery safety. Creating multifunctional separators offers an effective and cost-efficient solution for addressing fast charging and safety challenges in LMBs. This study proposes a method to prepare a functional separator by in situ growing a polydopamine copper chelate (PDA(Cu)) coating on a polypropylene (PP)/polyethylene (PE)/PP separator (PP/PE/PP@PDA(Cu)). The PDA(Cu) exhibits excellent electrolyte wetting properties and ion exclusion effects, contributing to high ionic conductivity (5.02 × 10 − ⁴ S cm −1 ) and high lithium-ion (Li + ) transference number (0.776). Owing to its strong adhesion to the lithium metal anode, the coating significantly suppresses the formation of lithium dendrites. The Li||Li symmetric cell with a PP/PE/PP@PDA(Cu) separator demonstrates highly stable lithium plating-stripping cycles, lasting over 900 h. Additionally, the PDA(Cu) promotes the formation of a stable cathode electrolyte interphase (CEI) film on the LiFePO 4 cathode surface. The LiFePO 4 ||Li cell with a PP/PE/PP@PDA(Cu) separator maintains 85.1% of its capacity after 6000 cycles at 10 C. This work paves a novel path for designing separators to enhance the fast-charging performance of LMBs and solve the challenges of lithium dendrite formation and long cycling life.}, archive = {J_ADVS}, author = {Shixiang Liu and Qiang Liu and Pu Cheng and Xingkai Jia and Yinzhu Jiang and Xuan Zhang}, doi = {10.1002/advs.202501155}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501155}, shortjournal = {Adv. Sci.}, title = {Polydopamine chelate modified separators for lithium metal batteries with high-rate capability and ultra-long cycling life}, volume = {12}, year = {2025}, }
• (2025). Vermicular eutectic multi-principal element alloy with exceptional strength and ductility. ADVS, 12(25), 2501150. (www)

  @article{ , abstract = {Eutectic multi-principal element alloys (EMPEAs), with multiple main elements in compositions and eutectic microstructures, are considered promising high-performance materials for structural applications. The microstructure of EMPEAs usually exhibits a mixture of soft and hard phases in straight rod-like or lamellar morphology, which contribute to a balanced synergy of strength and ductility. However, such conventional morphology may also constrain the possible space for further improving their mechanical properties, and the question proposed is whether the straight morphology can be kinked to unlock a new space for achieving better mechanical properties. Here an (AlCrFe 2 ) 65 Ni 35 EMPEA featuring an unseen kinked vermicular eutectic microstructure is successfully prepared. This innovative microstructure imparts remarkably improved strength-ductility synergy to the EMPEA, which surpasses both its coarse-grained counterpart and typical EMPEAs with straight morphologies, indicating a pronounced strengthening of the vermicular eutectic microstructure. The phase-field simulation reveals the formation of such microstructure as the lack of crystallographic locking caused by the similar elastic modulus of the two eutectic phases. The findings not only expand the family of possible eutectic microstructures but also offer a pioneering paradigm for enhancing EMPEAs, paving the way for their application in high-performance structural materials.}, archive = {J_ADVS}, author = {Liufei Huang and Yicheng Han and Yaoning Sun and A. S. L. Subrahmanyam Pattamatta and Junhua Luan and Qing Wang and Congcong Ren and Yuanfeng Zhou and Jinfeng Li and Hengwei Luan and Peter K. Liaw and Jian Lu}, doi = {10.1002/advs.202501150}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501150}, shortjournal = {Adv. Sci.}, title = {Vermicular eutectic multi-principal element alloy with exceptional strength and ductility}, volume = {12}, year = {2025}, }
• (2025). Neoadjuvant chemotherapy with cisplatin up-regulates GSDMD to enhance oral squamous cell carcinoma metastasis through MMP14-mediated EMT activation. ADVS, 12(25), 2501149. (www)

  @article{ , abstract = {Neoadjuvant chemotherapy has been widely used for the treatment of solid tumors. However, clinical observations have shown that patients with oral squamous cell carcinoma (OSCC) who are receiving neoadjuvant chemotherapy with cisplatin still face issues such as a poor lymph node response and even lymph node progression, but the underlying mechanisms remain unidentified. In this work, it is found that low-dose cisplatin promoted oral squamous cell carcinoma migration, invasion and lymph node metastasis, and gasdermin D (GSDMD) is identified as a potential regulator. GSDMD interacted with MMP14, promoting its expression and epithelial‒mesenchymal transition (EMT) activation without activating pyroptosis. Moreover, pH-responsive nanoparticles (NPs) for the systemic delivery of a GSDMD siRNA (siGSDMD) is developed and showed that this NP-delivered siGSDMD can effectively inhibit OSCC tumor growth and metastasis via the efficient silencing of GSDMD expression in vivo. This findings indicate that GSDMD can be a biomarker to predict the prognosis of OSCC patients receiving neoadjuvant chemotherapy and that NP-mediated GSDMD silencing can be a promising strategy for the treatment of patients with advanced OSCC receiving neoadjuvant chemotherapy with cisplatin.}, archive = {J_ADVS}, author = {Zixian Huang and Qiming Jiang and Qianyu Zhang and Nan Lu and Xi Rui and Rui Chen and Yan Wang and Yuepeng Wang and Xiaoding Xu and Zhiquan Huang}, doi = {10.1002/advs.202501149}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501149}, shortjournal = {Adv. Sci.}, title = {Neoadjuvant chemotherapy with cisplatin up-regulates GSDMD to enhance oral squamous cell carcinoma metastasis through MMP14-mediated EMT activation}, volume = {12}, year = {2025}, }
• (2025). Suspended tissue open microfluidic patterning (STOMP). ADVS, 12(25), 2501148. (www)

  @article{ , abstract = {Free-standing tissue structures tethered between pillars are powerful mechanobiology tools for studying cell contraction. To model interfaces ubiquitous in natural tissues and upgrade existing single-region suspended constructs, we developed Suspended Tissue Open Microfluidic Patterning (STOMP), a method to create multi-regional suspended tissues. STOMP uses open microfluidics and capillary pinning to pattern subregions within free-standing tissues, facilitating the study of complex tissue interfaces, such as diseased-healthy boundaries (e.g., fibrotic-healthy) and tissue-type interfaces (e.g., bone-ligament). We observed altered contractile dynamics in fibrotic-healthy engineered heart tissues compared to single-region tissues and differing contractility in bone-ligament enthesis constructs compared to single-tissue periodontal ligament models. STOMP is a versatile platform – surface tension-driven patterning removes material requirements common with other patterning methods (e.g., shear-thinning, photopolymerizable) allowing tissue generation in multiple geometries with native extracellular matrices and advanced four-dimensional (4D) materials. STOMP combines the contractile functionality of suspended tissues with precise patterning, enabling dynamic and spatially controlled studies.}, archive = {J_ADVS}, author = {Amanda J. Haack and Lauren G. Brown and Alex J. Goldstein and Priti Mulimani and Jean Berthier and Asha R. Viswanathan and Irina Kopyeva and Jamison M. Whitten and Ariel Lin and Serena H. Nguyen and Thomas P. Leahy and Ella E. Bouker and Ruby M. Padgett and Natalie A. Mazzawi and Jodie C. Tokihiro and Ross C. Bretherton and Aaliyah Wu and Stephen J. Tapscott and Cole A. DeForest and Tracy E. Popowics and Erwin Berthier and Nathan J. Sniadecki and Ashleigh B. Theberge}, doi = {10.1002/advs.202501148}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501148}, shortjournal = {Adv. Sci.}, title = {Suspended tissue open microfluidic patterning (STOMP)}, volume = {12}, year = {2025}, }
• (2025). Identification and application of a novel patulin degrading enzyme from meyerozyma guilliermondii. ADVS, 12(25), 2501146. (www)

  @article{ , abstract = {Patulin (PAT), a highly toxic mycotoxin, poses significant health risks due to its contamination of fruits and their derived products. Recent biological strategies for eliminating PAT mainly focus on elucidating the molecular detoxification processes of antagonistic microorganisms using omics technologies. However, there is still a scarcity of research on the rapid screening and catalytic mechanisms of bio-enzymes. In this study, a short-chain dehydrogenase/reductase (MgSDR1) capable of degrading PAT is rapidly identified from Meyerozyma guilliermondii by integrating transcriptomics with molecular docking. MgSDR1 completely degrades PAT into E -ascladiol within 2 h within the presence of reduced nicotinamide adenine dinucleotide phosphate (NADPH). Biodegradation efficiency is influenced by temperature, pH, enzyme/substrate concentrations, metal ions, and organic reagents. Notably, MgSDR1 shows efficient PAT degradation ability in fresh pear juice while maintaining key quality parameters, such as color parameters, pH, polyphenol oxidase activity, the contents of vitamin C, total phenols, titratable acidity, and soluble solids. The degradation process enhances the antioxidant capacity and enriches the aromatic compounds of the juice. Furthermore, site-directed mutagenesis reveals the essential role of the catalytic triad (Ser174-Tyr188-Lys192) in MgSDR1 activity. This study provides an efficient methodology for screening PAT-degrading enzymes and lays a theoretical foundation for the removal of mycotoxins in the food industry.}, archive = {J_ADVS}, author = {Yu Zhang and Qianhua Zhao and Solairaj Dhanasekaran and Esa Abiso Godana and Yue Zhang and Xue Bai and Qiya Yang and Hongyin Zhang}, doi = {10.1002/advs.202501146}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501146}, shortjournal = {Adv. Sci.}, title = {Identification and application of a novel patulin degrading enzyme from meyerozyma guilliermondii}, volume = {12}, year = {2025}, }
• (2025). Mechanical biomimetic nanocomposites for multidimensional treatment of arterial thrombosis. ADVS, 12(25), 2501134. (www)

  @article{ , abstract = {Arterial thrombosis is a severe cardiovascular condition associated with high mortality and disability rates. Traditional pharmacological thrombolytic therapies, however, are limited by a narrow therapeutic window, short drug half-lives, restricted therapeutic effectiveness, and the risk of hemorrhagic complications. Moreover, the unique biological microenvironment of arterial thrombosis is characterized by high shear stress and an inflammatory milieu rich in reactive oxygen species (ROS), resulting in a relatively high recurrence rate. To address these challenges, a mechanical biomimetic nanocomposite MPB-NO-UK@PM is developed by doping sodium nitroprusside, a nitric oxide (NO) donor, into mesoporous Prussian blue (MPB) nanoparticles to form MPB-NO, which is then loaded with urokinase (UK) and coated with platelet membranes (PM). The nanocomposite exhibits excellent thrombus-targeting ability and enhances thrombolytic efficacy through synergistic photothermal and pharmacological, while simultaneously reducing the risk of bleeding. The released NO induces antiplatelet aggregation effects, while Prussian blue effectively scavenges ROS and inflammatory cytokines, thereby preventing thrombus recurrence. Additionally, the nanocomposite possesses superior photoacoustic imaging capabilities, enabling visualization of thrombus diagnosis and treatment. This therapeutic approach represents a novel pathway for the multidimensional and efficient management of arterial thrombosis.}, archive = {J_ADVS}, author = {Ying Li and Qi Xiang and Yan Zhang and Fuxue Luo and Yunfang Wu and Haitao Ran and Yang Cao}, doi = {10.1002/advs.202501134}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501134}, shortjournal = {Adv. Sci.}, title = {Mechanical biomimetic nanocomposites for multidimensional treatment of arterial thrombosis}, volume = {12}, year = {2025}, }
• (2025). MAGEA6 engages a YY1-dependent transcription to dictate perineural invasion in colorectal cancer. ADVS, 12(25), 2501119. (www)

  @article{ , abstract = {Perineural invasion (PNI), characterized by tumor cells surrounding and invading nerves, is associated with poor prognosis in colorectal cancer (CRC). Understanding the mechanisms of PNI is crucial for developing targeted therapies to impede tumor progression. In this study, clinical information and transcriptome data are obtained from the TCGA database. Stable MAGEA6 knockdown CRC cell lines are established to investigate the impact of MAGEA6 on CRC malignancy. Immunohistochemical staining is used to assess the clinical significance of MAGEA6. Rectal orthotopic and sciatic nerve invasion models are employed to verify the role of MAGEA6 in PNI. Schwann cells (SCs) infiltration and recruitment by CRC cells are assessed using ssGSEA and co-culture experiments. The results reveal that MAGEA6 is a key regulator of PNI, with its expression correlating with poor prognosis. MAGEA6 knockdown reduces CRC cell migration, invasion, and PNI ability. Moreover, CRC cells recruit SCs, with CXCL1 promoting SCs migration. Mechanistically, MAGEA6 inhibits YY1 ubiquitination, stabilizing YY1 expression and enhancing SC recruitment via YY1-mediated CXCL1 transcription. These findings suggest that MAGEA6 enhances CRC invasiveness and PNI by stabilizing YY1, which upregulates CXCL1 secretion and promotes SC recruitment. This interaction underscores the critical role of MAGEA6 in PNI and highlights a potential therapeutic target in CRC.}, archive = {J_ADVS}, author = {Hao Wang and Kexin He and Ruixue Huo and Weihan Li and Shan Zhang and Lu-Ju Jiang and Hao Wu and Minhao Yu and Shu-Heng Jiang and Junli Xue}, doi = {10.1002/advs.202501119}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501119}, shortjournal = {Adv. Sci.}, title = {MAGEA6 engages a YY1-dependent transcription to dictate perineural invasion in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Calpain-2-mediated endothelial focal adhesion disruption in thoracic aortic dissection. ADVS, 12(25), 2501112. (www)

  @article{ , abstract = {Thoracic aortic dissection (TAD) is a life-threatening condition with high mortality rates. Recent research suggests a potential link between early-stage TAD and endothelial barrier dysfunction, although the underlying mechanisms remain unclear. Single-cell RNA sequencing data from patients reveal that dysregulated Calpain-2 expression modulates endothelial focal adhesion proteins, serving as an early pathological hallmark and driver of TAD. Elevated plasma calpain activity is strongly associated with an increased risk of TAD and organ dysfunction. Both endogenous and exogenous calpain inhibitors effectively prevent TAD onset and progression in murine models induced by β-aminopropionitrile (BAPN). In early TAD, endothelial junction integrity in the ascending aorta and aortic arch is compromised. Endothelial-specific deletion of Capns1 mitigates early and sustained endothelial focal adhesion damage by reducing aberrant expression of Integrin alpha-V(Itgav), vinculin, and talin-1, thereby decreasing TAD incidence. In contrast, macrophage-specific Capns1 knockout does not impact TAD development but accelerates aortic dissection rupture in later stages. Mechanistically, angiotensin II upregulates Calpain-2, leading to endothelial focal adhesion activation through talin1 cleavage and Itgav assembly, thereby compromising endothelial integrity and permeability. These findings identify potential therapeutic targets for TAD prevention and treatment.}, archive = {J_ADVS}, author = {Xiaomei Teng and Yansong Wang and Haoyue Huang and Yinglong Ding and Jun Wang and Meili Liu and Kun Song and Lianbo Shao and You Yu and Ziying Yang and Zhenya Shen}, doi = {10.1002/advs.202501112}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501112}, shortjournal = {Adv. Sci.}, title = {Calpain-2-mediated endothelial focal adhesion disruption in thoracic aortic dissection}, volume = {12}, year = {2025}, }
• (2025). FABP4 as a mediator of lipid metabolism and pregnant uterine dysfunction in obesity. ADVS, 12(25), 2501077. (www)

  @article{ , abstract = {Obese pregnant women in late pregnancy are more susceptible to uterine smooth muscle dysfunction, but the underlying mechanisms remain elusive. Here, elevated levels of fatty acid binding protein 4 (FABP4) in the myometrium of obese pregnant women at term, high-fat diet (HFD)-induced obese mice, and palmitic acid-treated uterine smooth muscle cells (USMCs), are demonstrated. FABP4 plays a critical role in transporting fatty acids from the extracellular to the intracellular compartment. Mechanistically, obesity promotes excessive fatty acid uptake, leading to aberrant lipid accumulation and reduced ATP production in USMCs. These abnormalities stem from weakened coupling of mitochondria-associated membranes, which are essential for calcium, lipids, and metabolites exchange. Furthermore, adenoviral injection to elevate FABP4 levels in normal-diet mice mimicks the effects observed in HFD mice. Collectively, these findings highlight FABP4 as a key driver of myometrial dysfunction in obesity and a potential therapeutic target for improving labor outcomes in obese pregnancies.}, archive = {J_ADVS}, author = {Xuan Li and Huihui Yu and Ruixian Tian and Xingxing Wang and Ting Xing and Chenyi Xu and Tengteng Li and Xue Du and Qianqian Cui and Biao Yu and Yunxia Cao and Zongzhi Yin}, doi = {10.1002/advs.202501077}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501077}, shortjournal = {Adv. Sci.}, title = {FABP4 as a mediator of lipid metabolism and pregnant uterine dysfunction in obesity}, volume = {12}, year = {2025}, }
• (2025). Achieving high damping capacity in oxygen-enhanced BCC zr-hf-ti-nb multi-principal-element alloys with low young's modulus. ADVS, 12(25), 2501068. (www)

  @article{ , abstract = {Multi-principal-element alloys (MPEAs) have gained widespread popularity due to the efficient synergetic regulation of mechanical and functional properties in a huge compositional space. Here, novel O-enhanced BCC Zr-Hf-Ti-Nb MPEAs with prominent mechanical and damping properties are developed by the composition formula of (Zr,Hf,Ti) 15 Nb 3 . The Zr 14 TiNb 3 and Zr 8 Hf 6 TiNb 3 alloys possess low BCC-β structural stability. While the Zr 8 Hf 4 Ti 3 Nb 3 alloy has a much higher BCC-β stability, as evidenced by the fact that only few α'' and ω precipitates appear in 1.8 at% oxygen-added alloy. This alloy exhibits an optimal mechanical property with a higher yield strength ( σ YS = 1000 MPa) and larger ductility ( ε = 15.1%), which is ascribed to the formation of O-rich clusters in BCC matrix. Moreover, these oxygen-free and -added alloys exhibit an excellent damping capacity due to their low Young's modulus ( E < 70 GPa), as exemplified with a peak value of (tan δ ) max = 0.02 for 1.8 at% oxygen-added alloy. Notably, the damping characteristics are prominent over a wide temperature range (550–800 K), which derives from the occurrence of multiple separated oxygen-rich clusters. The present findings provide an avenue to enhance mechanical and functional performances of high-temperature damping alloys.}, archive = {J_ADVS}, author = {Qing Wang and Zhenhua Wang and Qixiang Zhang and Rui Wang and Tongmin Wang and Chaoli Ma and Ang Li and Xiaodong Han and Junhua Luan and Zengbao Jiao and Peter K. Liaw}, doi = {10.1002/advs.202501068}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501068}, shortjournal = {Adv. Sci.}, title = {Achieving high damping capacity in oxygen-enhanced BCC zr-hf-ti-nb multi-principal-element alloys with low young's modulus}, volume = {12}, year = {2025}, }
• (2025). Enhancement of optical transparency and electrical conductivity of IZO/Ag/IZO multilayer film by intense pulsed light and its effect on the photovoltaic performances of perovskite solar cells. ADVS, 12(25), 2501058. (www)

  @article{ , abstract = {A highly conductive and transparent oxide/metal/oxide (OMO) multilayer transparent electrode is developed by flash lamp annealing (FLA). A transient thermal effect of FLA on the sandwich structure of the ultrathin Ag layer and zinc-doped indium oxide (IZO) layer is systematically investigated. FLA enables IZO/Ag/IZO multilayer to maintain the continuous ultrathin Ag interlayer and improve the crystallinity of the IZO layers. This is due to a very short processing time, absorption of visible light by the Ag layer, heat transfer from the Ag layer to the IZO layer, and mechanical constraint of the Ag layer by neighbor IZO layers. This combination of continuous ultrathin Ag layer and highly crystalline IZO layer decreases light scattering in a visible range and allows the electron donation from the Ag layer of a high electron concentration to neighbor IZO layers of a high electron mobility. IZO/Ag/IZO multilayer film from an optimal FLA process achieves a very low sheet resistance of 4.1 Ω sq −1 and a high optical transmittance (90.1%) in the broadband range of 400–800 nm. A perovskite solar cell in the best IZO/Ag/IZO transparent electrode exhibits better current generation and higher fill factor than a device of FTO electrode.}, archive = {J_ADVS}, author = {Sumin Bae and Youngsoo Jung and Vishal Pal and Jung-Kun Lee}, doi = {10.1002/advs.202501058}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501058}, shortjournal = {Adv. Sci.}, title = {Enhancement of optical transparency and electrical conductivity of IZO/Ag/IZO multilayer film by intense pulsed light and its effect on the photovoltaic performances of perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). The FGF13-caveolin-1 axis: A key player in the pathogenesis of doxorubicin- and D-galactose-induced premature cardiac aging. ADVS, 12(25), 2501055. (www)

  @article{ , abstract = {Delaying senescence of cardiomyocytes has garnered widespread attention as a potential target for preventing cardiovascular diseases (CVDs). FGF13 (Fibroblast growth factor 13) has been implicated in various pathophysiological processes. However, its role in premature myocardial aging and cardiomyocyte senescence remains unknown. Adeno-associated virus 9 (AAV9) vectors expressing FGF13 and cardiac-specific Fgf13 knockout (Fgf13KO) mice are utilized to reveal that FGF13 overexpression and deficiency exacerbated and alleviated Doxorubicin/D-galactose-induced myocardial aging characteristics and functional impairment, respectively. Transcriptomics are employed to identify an association between FGF13 and Caveolin-1 (Cav1). Mechanistic studies indicated that FGF13 regulated the Cav1 promoter activity and expression through the p38/MAPK pathway and nuclear translocation of p65, as well as the binding level of PTRF to Cav1 to mediate cardiomyocyte senescence. Furthermore, Cav1 overexpression in murine hearts reversed the alleviatory effects of FGF13 deficiency on the Doxorubicin/D-galactose-induced myocardial aging phenotype and dysfunction. This study has demonstrated that FGF13 regulated the Cav1-p53-p21 axis to augment cardiomyocyte senescence and thereby exacerbated cardiac premature aging and suggests that FGF13 knockdown may be a promising approach to combat CVDs in response to aging and chemotoxicity.}, archive = {J_ADVS}, author = {Enzhao Shen and Yuecheng Wu and Weijian Ye and Sihang Li and Junjie Zhu and Meifan Jiang and Zhicheng Hu and Gaoyong Cao and Xiaojing Yi and Fan Li and Zhouhao Tang and Xiaokun Li and Kwang Youl Lee and Litai Jin and Xu Wang and Weitao Cong}, doi = {10.1002/advs.202501055}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501055}, shortjournal = {Adv. Sci.}, title = {The FGF13-caveolin-1 axis: A key player in the pathogenesis of doxorubicin- and D-galactose-induced premature cardiac aging}, volume = {12}, year = {2025}, }
• (2025). Robust controlled degradation of enzyme loaded PCL-based fibrous scaffolds toward scarless skin tissue regeneration. ADVS, 12(25), 2501053. (www)

  @article{ , abstract = {Uncontrolled degradation of wound dressings may result in residues, causing several negative effects on wound healing, such as secondary damage, undesirable inflammation, and scar skin formation. Here, an available strategy associated with the synthesis of enzyme-loaded ( Burkholderia cepacia lipase, BCL) polycaprolactone (PCL) nanofiber scaffolds, aligning with wound healing effects is reported. These scaffolds are fabricated via fiber microfluidic electrospinning degradation-control technique. The obtained scaffolds exhibit tunable degradation rates, achieving complete degradation within 12–72-h cycles. The acidic degradation products are further elucidated and reveal the potential degradation mechanism. The acidic degradation products create an optimal microenvironment during the hemostasis and inflammation stages of wound healing. Notably, in vivo experiments demonstrate the enzyme-loaded scaffolds effectively promote angiogenesis, reduce inflammatory responses, mitigate collagen deposition, and regulate fibroblast differentiation. This promotes rapid wound healing with a remarkable scarless rate of over 99% by day 21. New guidelines for scar-free healing dressings are proposed, which carry out faster degradation without microplastics (MPs) and toxic byproducts before scar formation. These principles might provide valuable insights and promise for developing more effective wound dressings.}, archive = {J_ADVS}, author = {Lingling Fan and Weiliang Dong and Jianqi Lu and Yujia Peng and Bin Xie and Ping Wei and Min Jiang and Su Chen}, doi = {10.1002/advs.202501053}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501053}, shortjournal = {Adv. Sci.}, title = {Robust controlled degradation of enzyme loaded PCL-based fibrous scaffolds toward scarless skin tissue regeneration}, volume = {12}, year = {2025}, }
• (2025). In situ and real-time multi-modality imaging guided orderly triple-therapy of tumors with a multifunctional nanodrug. ADVS, 12(25), 2501048. (www)

  @article{ , abstract = {Effective integration of different therapeutic methods is a promising way to improve the overall efficacy of tumor therapy, which needs to be guided by in situ and real-time monitoring of each therapeutic process. Here a multifunctional AuNR@SiO 2 @MnO 2 @DNA prodrugs (ASMD) nanodrug is designed for orderly photothermal therapy (PTT)/chemodynamic therapy (CDT)/gene therapy (GT) triple-therapy of tumors, which can be guided by the in situ and real-time photoacoustic (PA)/magnetic resonance (MR)/fluorescence (FL) multi-modality imaging. The gold nanorod in ASMD can generate a PA signal and perform PTT. The MnO 2 in ASMD can respond to the glutathione inside tumor cells to release Mn 2+ , which can generate MR signal and perform CDT by catalyzing the degradation of intracellular H 2 O 2 to generate · OH. The DNA prodrugs can perform a cascade response in the presence of the released Mn 2+ and the intracellular microRNA 21, which can turn on the quenched FL signal and release small-interfering RNA and antisense oligonucleotide to perform GT. Guiding by the in situ and real-time PA/MR/FL multi-modality imaging of each therapeutic process, an orderly PTT/CDT/GT triple-therapy of tumors is established, which provides a significant and promising strategy to develop more efficient and practical therapeutic programs for tumors.}, archive = {J_ADVS}, author = {Chaoyi Yang and Yuexuan Meng and Ying An and Jing Jia and Yuru Wang and Guangming Li and Yiran Li and Shan Wu and Chengyao Geng and Yunlong Chen and Huangxian Ju}, doi = {10.1002/advs.202501048}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501048}, shortjournal = {Adv. Sci.}, title = {In situ and real-time multi-modality imaging guided orderly triple-therapy of tumors with a multifunctional nanodrug}, volume = {12}, year = {2025}, }
• (2025). Mechanical load-induced upregulation of talin2 through non-canonical deubiquitination of OTUB1 drives facet joint osteoarthritis pathogenesis. ADVS, 12(25), 2501046. (www)

  @article{ , abstract = {Facet joint osteoarthritis (FJOA) is a prevalent degenerative condition in the aging population; however, the underlying pathophysiological mechanisms remain poorly understood and current therapeutic strategies remain limited to palliative pain management. In this study, novel potential therapeutic targets and prevention paradigms for FJOA are systematically explored. Proteomic screening and validation show that Talin2 is specifically upregulated in FJOA samples. Immunoprecipitation-mass spectrometry, transcriptome RNA sequencing, and bioinformatics simulation analyses, combined with in vitro and in vivo experiments, are conducted to elucidate the molecular mechanism of the role of Talin2 in FJOA. Increased expression levels of Talin2 in FJOA promote the degradation of the extracellular matrix and inhibit its synthesis. Talin2 is found to be stabilized via non-canonical deubiquitination and direct interaction with ovarian tumor domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1). C–C motif ligand 2 ( CCL2 ), an inflammatory chemoattractant, is identified to be a target gene of Talin2. Furthermore, mechanical loading potentiates the Talin2/OTUB1 interaction, resulting in the stabilization of Talin2 and enhances non-canonical deubiquitination. Therefore, Talin2 regulates CCL2 expression and promotes FJOA. Given that Talin2 is stabilized and deubiquitinated by OTUB1, especially under mechanical load, the Talin2/OTUB1 interaction may be a promising therapeutic target for FJOA.}, archive = {J_ADVS}, author = {Yizhen Huang and Heng Sun and Haojie Chen and Xiangpeng Wang and Junduo Zhao and Yang Jiao and Hongyi Zhou and Haoyu Cai and Jiafeng Dai and Xuan Huang and Weiyun Chen and Jianxiong Shen}, doi = {10.1002/advs.202501046}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501046}, shortjournal = {Adv. Sci.}, title = {Mechanical load-induced upregulation of talin2 through non-canonical deubiquitination of OTUB1 drives facet joint osteoarthritis pathogenesis}, volume = {12}, year = {2025}, }
• (2025). In vivo cytosolic delivery of biomolecules into neurons for super-resolution imaging and genome modification. ADVS, 12(25), 2501033. (www)

  @article{ , abstract = {Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research. Existing viral and non-viral delivery methods often suffer from inefficient intracellular access due to the endocytic pathway. Here, a neuron-targeting and direct cytosolic delivery platform is discovered by using a 15-amino-acid peptide, termed the N1 peptide, which enables neuron-specific targeting and cytosolic delivery of functional biomolecules. The N1 peptide initially binds hyaluronan in the extracellular matrix and subsequently passes the membrane of neurons without being trapped into endosome. This mechanism facilitates the efficient delivery of cell-impermeable and photo-stable fluorescent dye for super-resolution imaging of dendritic spines, and functional proteins, such as Cre recombinase, for site-specific genome modification. Importantly, the N1 peptide exhibits robust neuronal specificity across diverse species, including mice, rats, tree shrews, and zebra finches. Its targeting capability is further demonstrated through various administration routes, including intraparenchymal, intrathecal, and intravenous (i.v.) injections after blood-brain barrier (BBB) opening with focused ultrasound (FUS). These findings establish the N1 peptide as a versatile and functional platform with significant potential for bioimaging and advanced therapeutic applications.}, archive = {J_ADVS}, author = {Xiaoqian Ge and Joseph B. Wekselblatt and Scott Elmore and Bo Wang and Tongtong Wang and Renjinming Dai and Tingting Zhang and Harsh Dave and Mohammadaref Ghaderi and Athul Raj Anilkumar and Bill Wang and Shashank R. Sirsi and Jung-Mo Ahn and Mikhail G. Shapiro and Yuki Oka and Carlos Lois and Zhenpeng Qin}, doi = {10.1002/advs.202501033}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501033}, shortjournal = {Adv. Sci.}, title = {In vivo cytosolic delivery of biomolecules into neurons for super-resolution imaging and genome modification}, volume = {12}, year = {2025}, }
• (2025). The function of photocatalytic performance and carrier separation efficiency tuned by doping content in homogeneous photocatalysts. ADVS, 12(25), 2501026. (www)

  @article{ , abstract = {Homogeneous matrix materials are considered to be a solid guarantee of site-point charge transfer reactions because they are the main body of light absorption, photogenerated carrier separation, migration, and recombination processes. Elucidating the effect of carrier separation efficiency on catalytic performance is of great significance for overcoming the optimization obstacles of homogeneous matrix parts and providing new design strategies. In this study, TiO 2 doped with Fe as the research object quantifies the carrier dynamics while trying to avoid large site and lattice changes. The direct correlation between carrier separation efficiency and photocatalytic performance with different doping content samples is clearly elucidated by carrier dynamic characterization results. Doping of 0.213 wt.% Fe exhibits the best catalytic performance, achieving CO yield of 35.12 µmol g −1 h −1 . Especially, the femtosecond transient absorption spectroscopy demonstrates the defect level formed by doping Fe enhances the separation of photogenerated electrons. The clear relationship shown above, which is catalytic capacity mapping with carrier separation efficiency, rather than a linear dependence on sites and oxygen vacancies, fully demonstrates the great potential of simple doping strategies for homogeneous photocatalysts.}, archive = {J_ADVS}, author = {Chunxia Wen and Xinyue Ni and Mei Han and Yue Yu and Chuanqiang Liu and Yuan Zhang and Beining Zheng and Shouhua Feng}, doi = {10.1002/advs.202501026}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501026}, shortjournal = {Adv. Sci.}, title = {The function of photocatalytic performance and carrier separation efficiency tuned by doping content in homogeneous photocatalysts}, volume = {12}, year = {2025}, }
• (2025). The e3 ubiquitin ligase ARIH1 facilitates colorectal cancer progression by promoting oxidative phosphorylation via the mitochondrial translocation of k63-linked ubiquitinated PHB1. ADVS, 12(25), 2501017. (www)

  @article{ , abstract = {The RBR E3 ubiquitin ligase ARIH1 has been proven to induce specific ubiquitylation of substrates, thereby regulating cell proliferation and the cell cycle. However, the understanding of how ARIH1 influence cancer development is limited. This study revealed that ARIH1 is upregulated in colorectal cancer (CRC) cells and facilitates cell growth and metastasis. Clinically, high ARIH1 levels are linked to an unfavorable CRC prognosis. Mechanistically, ARIH1 directly interacts with PHB1 via its RING1+RBR+RING2 domains, catalyzing the K63-linked ubiquitination of PHB1 at lysine 186 (K186). The increased interaction between PHB1 and Akt through this modification results in PHB1 phosphorylation by Akt and its subsequent translocation into mitochondria, where it maintains mitochondrial stability and promotes oxidative phosphorylation (OXPHOS). Collectively, these findings demonstrate the role of ARIH1-mediated K63-linked ubiquitination of PHB1 in mitochondrial dynamics and OXPHOS, suggesting that it has potential as diagnostic biomarker and treatment target for CRC.}, archive = {J_ADVS}, author = {Ying Tong and Zhenling Wang and Yong Wang and Yang Chen and Hongqiang Zhang and Yunfei Lu and Lei Xu and Hengyang Shen and Changzhi Huang and Min Zhao and Wenjie Li and Shuai Wang and Yu Shao and Zan Fu}, doi = {10.1002/advs.202501017}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2501017}, shortjournal = {Adv. Sci.}, title = {The e3 ubiquitin ligase ARIH1 facilitates colorectal cancer progression by promoting oxidative phosphorylation via the mitochondrial translocation of k63-linked ubiquitinated PHB1}, volume = {12}, year = {2025}, }
• (2025). Encapsulation of metal nanoparticles by Metal–Organic framework imaged with in situ liquid phase transmission electron microscopy. ADVS, 12(25), 2500984. (www)

  @article{ , abstract = {Metal nanoparticle@metal−organic framework (NP@MOF) composites hold promise for potential applications in gas storage, catalysis, sensing, environmental monitoring, and biomedicine. Despite their importance, details of how MOFs encapsulate the NPs to form NP@MOF hybrid nanostructures are largely unexplored. Here, using ultra-low electron-flux in situ liquid phase transmission electron microscopy (LP-TEM), the encapsulation of Au NPs with zeolitic imidazolate framework-8 (ZIF-8) is visualized. These observations reveal that the speeds at which MOFs nucleate on the NP's surface impact the shell's shape. At low concentrations of MOF precursor, NPs are encapsulated with well-defined single-crystalline MOF shells, while at high concentrations, MOFs tend to nucleate and grow from multiple sites on the NP surface, resulting in irregularly shaped polycrystalline MOF shells. This approach, which uses a very low electron flux to image the synthesis of Au@ZIF-8 nanostructures, can be extended to imaging crucial processes in many other beam-sensitive materials and help design hybrid systems for a broad range of applications.}, archive = {J_ADVS}, author = {Guoming Lin and Utkur Mirsaidov}, doi = {10.1002/advs.202500984}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500984}, shortjournal = {Adv. Sci.}, title = {Encapsulation of metal nanoparticles by Metal–Organic framework imaged with in situ liquid phase transmission electron microscopy}, volume = {12}, year = {2025}, }
• (2025). Electrocatalytic CO2 reduction empowered by 2D hexagonal transition metal borides. ADVS, 12(25), 2500977. (www)

  @article{ , abstract = {Electrocatalysis holds immense promise for producing high-value chemicals and fuels through the carbon dioxide reduction reaction (CO 2 RR), advancing global sustainability and carbon neutrality. However, conventional electrocatalysts based on transition metals are often limited by significant overpotentials. Since the discovery of the first hexagonal MAB ( h -MAB) phase, Ti 2 InB 2 , and its 2D derivative in 2019, 2D hexagonal transition metal borides ( h -MBenes) have emerged as promising candidates for various electrochemical applications. This study presents the first theoretical investigation into the CO 2 RR catalytic properties of pristine h -MBenes ( h -MB) and their ─O ( h -MBO) and ─OH ( h -MBOH) terminated counterparts, focusing on metals such as Sc, Ti, V, Zr, Nb, Hf, and Ta. These results reveal while h -MB and h -MBO exhibit poor catalytic performance due to overly strong or weak interactions with CO 2 , h -MBOH shows great promise. Notably, ScBOH, TiBOH, and ZrBOH display exceptionally low limiting potentials ( U L ) of −0.46, −0.53, and −0.64 V, respectively. These findings uncover the unique role of ─OH in tuning the electronic properties of h -MBenes, thereby optimizing intermediate adsorption, which prevents excessive binding and enhances catalytic efficiency. This research offers valuable insights into the potential of h -MBenes as highly efficient CO 2 RR catalysts, underscoring their versatility and significant prospects for electrochemical applications.}, archive = {J_ADVS}, author = {Yaxin Di and Zhiqi Wang and Guangqiu Wang and Junjie Wang}, doi = {10.1002/advs.202500977}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500977}, shortjournal = {Adv. Sci.}, title = {Electrocatalytic CO2 reduction empowered by 2D hexagonal transition metal borides}, volume = {12}, year = {2025}, }
• (2025). Engineered stem cell clusters for extracellular vesicles-mediated gene delivery to rejuvenate chondrocytes and facilitate chondrogenesis in osteoarthritis therapy. ADVS, 12(25), 2500964. (www)

  @article{ , abstract = {Gene therapy offers an ideal potential treatment strategy for osteoarthritis (OA). However, the safe and efficient delivery of therapeutic genes remains highly challenging because of the inactivation in direct delivery of miRNA, low transfection efficiency, and a short half-life. This study introduced a gene therapy strategy using mesenchymal stem cells (MSCs) as a gene delivery platform and achieved the sustained delivery of therapeutic genes via engineered MSCs-derived extracellular vesicles (EVs). The miRNA-874-3p is combined with an exosome-targeting motif and transfected into bone marrow mesenchymal stem cells (BMSCs). The BMSCs motif+miR874 are then seeded onto hydrogel microspheres, creating the BMSC motif+miR874 /MS system for OA treatment. In vitro experiments demonstrated that miRNA-874-3p not only alleviated inflammation and oxidative stress-induced damage to chondrocytes by downregulating the NF-κB signaling pathway, thereby rejuvenating chondrocytes, but also promoted chondrogenesis in the inflammatory microenvironment. Furthermore, the engineered BMSCs in the system demonstrated prolonged retention in vivo, thereby enabling the sustained delivery of the therapeutic gene, miRNA-874-3p, over an extended duration. In the rat OA model, BMSC motif+miR874 /MS successfully delivered miRNA-874-3p to the articular cartilage and effectively alleviated cartilage degeneration. In conclusion, this EVs-mediated therapeutic gene delivery approach enables miRNA-based gene therapy a viable alternative to surgery for OA treatment and provides a novel option for gene therapy.}, archive = {J_ADVS}, author = {Yuezhou Wu and Yubo Feng and Fei Hu and Xu Zheng and Yurun Ding and Xuesong Liu and Shicheng Huo and Zhuocheng Lyu}, doi = {10.1002/advs.202500964}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500964}, shortjournal = {Adv. Sci.}, title = {Engineered stem cell clusters for extracellular vesicles-mediated gene delivery to rejuvenate chondrocytes and facilitate chondrogenesis in osteoarthritis therapy}, volume = {12}, year = {2025}, }
• (2025). Placental RTN3L-dependent ER-phagy contributes to fetal testicular dysplasia upon environmental stress. ADVS, 12(25), 2500924. (www)

  @article{ , abstract = {Prenatal environmental stress damages fetal testicular development, leading to male infertility. However, the precise mechanisms underlying the impact of gestational environmental stress on fetal testicular development require further investigation. This study demonstrates that gestational environmental stressor cadmium exposure caused placental estradiol synthesis inhibition and fetal testicular dysplasia. Gestational estradiol supplementation restores fetal testicular dysplasia caused by environmental stress-induced placental estradiol synthesis inhibition. Analysis of human placentae and cadmium-stimulated human primary placental trophoblasts confirmed that ER-phagy is associated with the inhibition of estradiol synthesis in placentae. Subsequently, the data reveals that environmental stress significantly activates RTN3L-mediated ER-phagy. RTN3L -deficient cells and placental Rtn3l -specific knockout mice confirm that environmental stress-activated RTN3L-mediated ER-phagy inhibited placental estradiol synthesis. Total N6-methyladenosine level increasing in gestational environmental stress-exposed placentae. METTL3-mediated N6-methyladenosine modification suppression obviously restrains environmental stress-activated RTN3L-dependent ER-phagy. In conclusion, gestational environmental stress activates ER-phagy by increasing placental Rtn3l mRNA N6-methyladenosine modification, inhibiting placental estradiol synthesis, and contributing to fetal testicular dysplasia. The study demonstrates the early prevention and treatment of adult male infertility from the perspective of fetal-derived diseases.}, archive = {J_ADVS}, author = {Ye-Xin Luo and Hua-Long Zhu and Bin-Bin Huang and Cheng-Fang Sun and Xin-Xin Zhang and Xin-Run Wang and Yi-Fan Hu and Xu-Dong Zhang and Shen-Dong Xu and Huan Zhou and Rui Pan and Wei Chang and Zhi Yuan and Yong-Wei Xiong and Xiao-Feng Xu and Ling-Li Zhao and De-Xiang Xu and Hua Wang}, doi = {10.1002/advs.202500924}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500924}, shortjournal = {Adv. Sci.}, title = {Placental RTN3L-dependent ER-phagy contributes to fetal testicular dysplasia upon environmental stress}, volume = {12}, year = {2025}, }
• (2025). The INAVA mRNA in extracellular vesicles activates normal ovarian fibroblasts by Phosphorylation–Ubiquitylation crosstalk of HMGA2. ADVS, 12(25), 2500912. (www)

  @article{ , abstract = {Ovarian cancer is an aggressive gynecological tumor usually diagnosed with widespread metastases. Extracellular vesicles (EVs), though recognized as important mediators of tumor metastasis, have received limited attention into their specific functions via the mRNA profiling. Here it is reported elevated expression and selective enrichment of INAVA mRNA in both plasma- and tissue-derived EVs from ovarian cancer patients, which is positively correlated with distant metastasis and poor prognosis. Functionally, INAVA mRNA, upon uptake and translation, activates normal ovarian fibroblasts (NOFs) and drives extensive peritoneum metastasis in the orthotopic xenograft mouse model. Mechanistically, INAVA competitively binds with high mobility group protein A2 (HMGA2) and consequently inhibit its interaction with vaccinia-related kinase 1 (VRK1), leading to reduced HMGA2 phosphorylation on Ser105. Interestingly, this inhibitory phosphorylation stabilizes HMGA2 via blocking tripartite motif-containing 21 (TRIM21) -mediated K48-linked ubiquitylation, and ultimately enhances the transcription of STAT3 to activate NOFs. Lastly, a cell-permeable peptide that disrupts the INAVA–HMGA2 interaction leads to attenuated NOF activation and provides a promising strategy for ovarian cancer therapy.}, archive = {J_ADVS}, author = {Lingkai Gu and Zhangjin Shen and Shizhen Shen and Conghui Wang and Yuwan Liu and Xinyi Wei and Mengxia Zheng and Jiaxin Gu and Xiaojing Chen and Yi Sun and Junfen Xu and Yan Lu and Weiguo Lu}, doi = {10.1002/advs.202500912}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500912}, shortjournal = {Adv. Sci.}, title = {The INAVA mRNA in extracellular vesicles activates normal ovarian fibroblasts by Phosphorylation–Ubiquitylation crosstalk of HMGA2}, volume = {12}, year = {2025}, }
• (2025). Palladium-catalyzed dual Csp2─Csp3 bond formation: A versatile platform for the synthesis of benzo-fused heterocycles. ADVS, 12(25), 2500897. (www)

  @article{ , abstract = {Transition-metal-catalyzed transformations offer a powerful approach to rapidly synthesize complex benzo-fused heterocycles, crucial for drug and material development. However, existing synthetic strategies face challenges such as limited functional group compatibility, reliance on complex ligands, and difficulties in controlling chemoselectivity with prefunctionalized substrates. Herein, a ligand-free Pd(II)/Cu(I) catalytic system is presented that facilitates reactions between arylsulfonyl chlorides and unactivated olefins under mild conditions, enabling the efficient synthesis of saturated benzo-fused six-membered heterocycles. This streamlined strategy employs dual Csp 2 ─Csp 3 bond formation, producing diverse N/O-polyheterocycles and allowing late-stage functionalization of bioactive molecules with excellent yields and high chemoselectivity. The key to the success of this reaction is the formation of high-valent Ar-Pd(III) intermediate, which drives the reaction through 1,2-Pd migration and electrophilic C─H arylation. This unique reactivity pathway facilitates the formation of benzo-fused heterocycles while effectively avoiding the β-H elimination typically associated with Heck-type reactions.}, archive = {J_ADVS}, author = {Jiahui Huang and Yuantao You and Yijian Ma and Xingying He and Yixiao Li and Arunachalam Kesavan and Chengzhi Jin and Chengshuo Shen and Min Zhang and Kedong Yuan}, doi = {10.1002/advs.202500897}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500897}, shortjournal = {Adv. Sci.}, title = {Palladium-catalyzed dual Csp2─Csp3 bond formation: A versatile platform for the synthesis of benzo-fused heterocycles}, volume = {12}, year = {2025}, }
• (2025). Smart Organic–Inorganic copolymer nanoparticles distinguish between microglia and cancer cells for synergistic immunotherapy in glioma. ADVS, 12(25), 2500882. (www)

  @article{ , abstract = {The stimulator of interferon genes (STING) pathway has emerged as a new immunotherapy strategy with potent local stimulation specificity, showing promising potential to counteract the immunosuppression in glioma. Herein, a tumor microenvironment (TME) responsive nanoagonists are developed based on an organic–inorganic copolymer composed of the polymer PC6AB coupled with manganous phosphate ionic oligomers (MnP). The degradation of nanoagonists into PC6AB and MnP in the acidic TME enables spatiotemporal control of their delivery to tumor cells and immune cells, respectively. PC6AB with membranolytic activity selectively interacts with tumor cell membranes to induce immunogenic cell death, while manganese metal can activate the STING pathway in immune cells and trigger downstream immunostimulatory signals. Nanoagonists can stimulate robust antitumor immunity after local injection into the brain extracellular space (ECS), showing significant therapeutic efficacy in mouse glioma. Nanoagonists can achieve spatiotemporal orchestration of STING activation in response to TME and enhance immune response against “cold” solid tumors, providing a promising approach for clinical immunotherapy.}, archive = {J_ADVS}, author = {Shiming Zhang and Kun Shang and Lidong Gong and Qian Xie and Jianfei Sun and Meng Xu and Xunbin Wei and Zhaoheng Xie and Xinyu Liu and Hao Tang and Zhengren Xu and Wei Wang and Haihua Xiao and Zhiqiang Lin and Hongbin Han}, doi = {10.1002/advs.202500882}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500882}, shortjournal = {Adv. Sci.}, title = {Smart Organic–Inorganic copolymer nanoparticles distinguish between microglia and cancer cells for synergistic immunotherapy in glioma}, volume = {12}, year = {2025}, }
• (2025). ScCompass: An integrated multi-species scRNA-seq database for AI-ready. ADVS, 12(25), 2500870. (www)

  @article{ , abstract = {Emerging single-cell sequencing technology has generated large amounts of data, allowing analysis of cellular dynamics and gene regulation at the single-cell resolution. Advances in artificial intelligence enhance life sciences research by delivering critical insights and optimizing data analysis processes. However, inconsistent data processing quality and standards remain to be a major challenge. Here scCompass is proposed, which provides a comprehensive resource designed to build large-scale, multi-species, and model-friendly single-cell data collection. By applying standardized data pre-processing, scCompass integrates and curates transcriptomic data from nearly 105 million single cells across 13 species. Using this extensive dataset, it is able to identify stable expression genes (SEGs) and organ-specific expression genes (OSGs) in humans and mice. Different scalable datasets are provided that can be easily adapted for AI model training and the pretrained checkpoints with state-of-the-art single-cell foundation models. In summary, scCompass is highly efficient and scalable database for AI-ready, which combined with user-friendly data sharing, visualization, and online analysis, greatly simplifies data access and exploitation for researchers in single-cell biology ( http://www.bdbe.cn/kun ).}, archive = {J_ADVS}, author = {Pengfei Wang and Wenhao Liu and Jiajia Wang and Yana Liu and Pengjiang Li and Ping Xu and Wentao Cui and Ran Zhang and Qingqing Long and Zhilong Hu and Chen Fang and Jingxi Dong and Chunyang Zhang and Yan Chen and Chengrui Wang and Guole Liu and Hanyu Xie and Yiyang Zhang and Meng Xiao and Shubai Chen and Haiping Jiang and Yiqiang Chen and Ge Yang and Shihua Zhang and Zhen Meng and Xuezhi Wang and Guihai Feng and Xin Li and Yuanchun Zhou}, doi = {10.1002/advs.202500870}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500870}, shortjournal = {Adv. Sci.}, title = {ScCompass: An integrated multi-species scRNA-seq database for AI-ready}, volume = {12}, year = {2025}, }
• (2025). Polymer brush-based asymmetric porous patch with excellent anti-bacterial and anti-contamination properties enables infectious abdominal wall defect repair. ADVS, 12(25), 2500865. (www)

  @article{ , abstract = {Well-integration of multiple bioactive components into a biological patch without damaging its cellular matrix structure is crucial for infectious abdominal wall defect repair but remains challenging. Herein, a novel asymmetric biological composite patch (bPVA/SIS + -NP) is developed by in situ introducing zwitterionic polyvinyl alcohol molecular brush (bPVA) hydrogel to a cationic small intestinal submucosal decellularized matrix (SIS + ) via a self-induced phase separation based united strategy. Due to its high hydrogen bonding crosslinking and strong mechanical interlocking with SIS + -NP layer, bPVA layer can maintain stable anti-contamination and the corresponding anti-adhesion properties in the contaminated environment. On the basis of preserving an original extracellular matrix skeleton, SIS + -NP layer can show strong contact anti-bacterial ability at the acute stage of repair together with the prolonged drug release during the healing stage of repair. Furthermore, the in situ combination of bPVA and SIS + -NP layers can lead to a high and stable burst pressure tolerance. By comprehensive control of bacteria and their necrotic products, bPVA/SIS + -NP patch can achieve anti-infection, anti-adhesion, and pro-healing properties in the infectious abdominal wall defect on rats. Therefore, the bPVA/SIS + -NP patch opens a new avenue for bio-friendly construction of multifunctional biological patches to address the stringent requirements of infectious abdominal wall defect repair.}, archive = {J_ADVS}, author = {Zeping Huang and Weiwen Liang and Binying Peng and Yang Ouyang and Zixin Chen and Mawsoom Mamut and Zhipeng Huang and Hui Wang and Rongkang Huang and Bo Ma and Bingna Zheng and Jian Cai}, doi = {10.1002/advs.202500865}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500865}, shortjournal = {Adv. Sci.}, title = {Polymer brush-based asymmetric porous patch with excellent anti-bacterial and anti-contamination properties enables infectious abdominal wall defect repair}, volume = {12}, year = {2025}, }
• (2025). Oxytocin-mediate modulation of splenic immunosuppression in chronic social stress through neuroendocrine pathways. ADVS, 12(25), 2500849. (www)

  @article{ , abstract = {Chronic social stress (CSS) is a significant public health challenge that negatively impacts behavior and immune function through brain-spleen interactions. Oxytocin (OT), a neuropeptide critical for social behavior and immune regulation, is upregulated during CSS, though its underlying mechanisms remain unclear. This study investigates the role of OT in splenic immune modulation using a murine model of CSS. Behavioral evaluations, serum oxytocin quantification, and splenic immunophenotypic analysis were performed. Splenic denervation confirmed OT’s neuromodulatory role, whereas OTR antagonism revealed its endocrine function. CSS-induced OT elevation was associated with immunosuppression, characterized by increased Foxp3⁺ regulatory T cells and reduced CD4⁺ T and CD19⁺ B cells. OT also modulated macrophage polarization, inhibiting M1-like (pro-inflammatory) and enhancing M2-like (anti-inflammatory) phenotypes. Denervation or pharmacological blockade of OT signaling partly reversed CSS-induced splenic immunosuppression but adversely affected survival in CSS-exposed mice. Additionally, denervation or OTR antagonism reduced the mice's response to social defeat, as shown by decreased social avoidance behavior. These findings suggest that OT-mediated immunosuppression likely represents a compensatory mechanism in response to chronic social stress. Targeting the OT–immune axis could offer innovative therapeutic approaches for stress-associated disorders by restoring immune homeostasis while maintaining behavioral integrity.}, archive = {J_ADVS}, author = {Yi-Shu Zhang and Hai-Chao Chen and Jia-Xin Cao and Si-Wei Zhou and Yue-Zhang Ma and Yu-Hong Jing}, doi = {10.1002/advs.202500849}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500849}, shortjournal = {Adv. Sci.}, title = {Oxytocin-mediate modulation of splenic immunosuppression in chronic social stress through neuroendocrine pathways}, volume = {12}, year = {2025}, }
• (2025). Hierarchically porous wearable composites for high-performance stretchable supercapacitors. ADVS, 12(25), 2500835. (www)

  @article{ , abstract = {With the rapid development of wearable electronic devices, the demand for flexible, durable, and high-performance energy storage systems has increased significantly. Nevertheless, maintaining stable electrochemical performance during stretching while ensuring high stretchability and mechanical stability remains a challenge. Herein, this study proposes a novel type of stretchable supercapacitors made from carbon nanotube (CNT) and styrene-butadiene-styrene (SBS) composite scaffolds prepared on pre-stretched carbon fabrics using the breath figure method. Hydrothermal treatment is then performed to grow NiCo-LDH at the treated carbon fabrics. This method induces the formation of a hierarchically porous structure under high humidity conditions, controls the hydrothermal growth of NiCo-LDH in the CNT/SBS composite scaffold, and significantly enhances the electrochemical performance and mechanical stability. The supercapacitor demonstrates remarkable retention of 94% capacitance under 80% tensile strain and sustains a small 8% degradation over 20 000 charge–discharge cycles, achieving a specific capacitance of 4948 mF cm⁻ 2 at 2 mA cm⁻ 2 . The device has an energy density of 801.6 µWh cm⁻ 2 (400.6 Wh kg⁻¹) and exhibits excellent performance at a power density of 3.5 mW cm⁻ 2 (1749.5 W kg⁻¹). These properties make the supercapacitors a potential for next-generation smart wearables and wearable electronics.}, archive = {J_ADVS}, author = {Jing Han and Bingang Xu and Cuiqin Fang and Juyang Wei and Zihua Li and Xinlong Liu and Yujue Yang and Qian Wang and Junze Zhang}, doi = {10.1002/advs.202500835}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500835}, shortjournal = {Adv. Sci.}, title = {Hierarchically porous wearable composites for high-performance stretchable supercapacitors}, volume = {12}, year = {2025}, }
• (2025). Single-pixel infrared miniaturized spectrometer enabled by ultra-broadband reconfigurable photodetection. ADVS, 12(25), 2500830. (www)

  @article{ , abstract = {Miniaturized spectrometers utilizing a single reconfigurable photodetector (PD) are highly attractive in the infrared (IR) range due to their advantages in terms of cost, ease of integration, and reduced system complexity. However, such devices usually suffer from either limited wavelength tuning range or high spectral correlation in spectral sampling. Here, a new concept based on tunable guided mode resonances and surface plasmon resonances in a simple liquid crystal/Au stack is proposed to break the wavelength tuning range limit and simultaneously enable low spectral correlation. A chip-scale IR spectrometer using a single-pixel PbS PD is realized with a remarkably large wavelength tuning range over 850 nm (1150–2000 nm) and high fidelity (mean square error ≈0.001) in spectrum measurement. Such a novel technique is applied in plastic sorting and demonstrated remarkable improvement in sorting accuracy benefiting from its broadband property and distinct spectral responses at various sampling biases. Furthermore, a post-tuned operating mode for efficient and accurate spectroscopy is demonstrated by customizing the wavelength/bias scanning strategies, demonstrating the high flexibility of this technology. Full-vector analysis considering the interface anchoring effect and the anisotropic gradient refractive index distribution of liquid crystal is conducted to reveal the fundamental principles of broadband light modulation.}, archive = {J_ADVS}, author = {Wenyue Liang and Xianghong Nan and Wenfeng Cai and Ning Tan and Qilin Zheng and Yuyao Lu and Yongyue Huang and Jiahao Yan and Dangyuan Lei and Long Wen and Yanjun Liu and Qin Chen}, doi = {10.1002/advs.202500830}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500830}, shortjournal = {Adv. Sci.}, title = {Single-pixel infrared miniaturized spectrometer enabled by ultra-broadband reconfigurable photodetection}, volume = {12}, year = {2025}, }
• (2025). 2D conductive MOFs intercalated in MXene interlayer for fast and trace detection of triethylamine at room temperature. ADVS, 12(25), 2500786. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) are newly developed materials for gas sensing applications currently. However, the prolonged response time limits their future applications because of their poor electrical conductivity. In this context, alternating stacked MXene@Cu-HHTP heterostructures characterized by a sandwich-type architecture comprised of Cu-HHTP (copper-catecholate frameworks), 2D conductive MOFs, and layered MXene achieve high-performance triethylamine (TEA) sensing. The unique interlayer pore architecture within the MXene@Cu-HHTP composites facilitates efficient mass transfer of gas molecules while retaining the large surface area and porosity characteristics of the MOFs, leading to rapid TEA response. MXene@Cu-HHTP composites respond to 50 ppm TEA in only 4 s and low detection limit (1 ppm). Demonstrated higher sensitivity compared to the original Cu-HHTP sensor (≈21 times at 200 ppm TEA). At room temperature and atmospheric conditions, the value of moisture resistance of MXene@Cu-HHTP composites can reach 80% through continuous real-time dynamic testing.}, archive = {J_ADVS}, author = {Hao Zhang and Wei Cao and Jingfeng Wang and Lei Guo and Pu-Hong Wang and Zhi-Jun Ding and Lingmin Yu}, doi = {10.1002/advs.202500786}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500786}, shortjournal = {Adv. Sci.}, title = {2D conductive MOFs intercalated in MXene interlayer for fast and trace detection of triethylamine at room temperature}, volume = {12}, year = {2025}, }
• (2025). Superior sodium metal anodes enabled by 3D hierarchical metallic scaffolds with enhanced sodiophilicity. ADVS, 12(25), 2500756. (www)

  @article{ , abstract = {Sodium-metal batteries (SMBs) are regarded as key for next-generation energy storage due to their high theoretical energy and potential cost effectiveness. However, Na-metal systems remain challenging by critical barriers, including severe Na dendrites growth and infinite huge volume change, which limit the feasibility of SMBs. Here, this work develops a 3D conductive scaffold consisting of vertical crystalline TiO 2 nanotube arrays embedded with ultrafine silver nanoparticles (denoted as Ag@TiO 2 NTAs) with ultrasonication-assisted in situ deposition method for high-performance SMBs. Significantly, the hierarchical hollow nanotubes with large surface area can reduce the current density to promote compact electrodeposition and guide the parallel growth of Na. Meanwhile, the sodiophilic Ag nanocrystals with strong interactions with Na + enable a marked reduction of the nucleation barriers. As a result, the Na metal anode with the Ag@TiO 2 NTAs host delivers remarkable electrochemical properties including ultralow voltage hysteresis and prolonged cycling stability over 3600 h. By pairing with a Na 3 V 2 (PO 4 ) 3 cathode, the SMBs achieve 87% capacity retention after 2000 cycles at 8 C, suggesting its potential application for highly stable Na anodes.}, archive = {J_ADVS}, author = {Chong Chen and Rui Yang and Jie Zhu and Wenjiao Yao and Yongbing Tang}, doi = {10.1002/advs.202500756}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500756}, shortjournal = {Adv. Sci.}, title = {Superior sodium metal anodes enabled by 3D hierarchical metallic scaffolds with enhanced sodiophilicity}, volume = {12}, year = {2025}, }
• (2025). The role of MCPIP1 in macrophage polarization and cardiac function post-myocardial infarction. ADVS, 12(25), 2500747. (www)

  @article{ , abstract = {Macrophages play a critical role in both initiating and resolving inflammation following MI (myocardial infarction). Their polarization is essential for maintaining cardiac function. This study aims to explore the role of MCPIP1(Monocyte chemotactic protein-induced protein 1) in regulating macrophage polarization and its impact on heart-spleen interactions during MI recovery. The role of MCPIP1 was investigated using histological staining, RNA sequencing of bone marrow-derived macrophages, co-culture experiments, and validated by western blot. Compared to controls, myeloid MCPIP1-deficient mice had lower survival rates, larger infarction areas, and more severe inflammatory responses after MI. This was due to increased M1 polarization and impaired conversion to the M2 phenotype. Ferroptosis activation in MCPIP1-deficient macrophages was inhibited by Fer-1 and PFT-α, which promoted M2 polarization and fibroblast activation into myofibroblasts. MCPIP1-deficient MI mice also showed splenomegaly and elevated levels of circulating macrophages, indicating excessive extramedullary hematopoiesis. Splenectomy improved survival rates and reduced infarction size in MCPIP1-deficient mice. MCPIP1 suppresses the P53/ferroptosis pathway to regulate macrophage polarization and TGF-β/SMAD3-mediated fibroblast activation. Its deficiency exacerbates inflammation through abnormal splenic macrophage output, impairing cardiac repair. MCPIP1 is a promising therapeutic target for modulating ferroptosis and heart-spleen communication to protect cardiac function following MI.}, archive = {J_ADVS}, author = {Xingxu Zhang and Yuan Fang and Xiaoming Qin and Yiwei Zhang and Bo Kang and Li Zhong and Baoxin Liu and Jiachen Luo and Yidong Wei}, doi = {10.1002/advs.202500747}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500747}, shortjournal = {Adv. Sci.}, title = {The role of MCPIP1 in macrophage polarization and cardiac function post-myocardial infarction}, volume = {12}, year = {2025}, }
• (2025). Water-enhanced multicolor electrochromism in nickel-catecholate MOFs. ADVS, 12(25), 2500678. (www)

  @article{ , abstract = {Metal–organic frameworks (MOFs) represent a novel electrochromic material system but are limited in tunable color versatility, rapid switching speed, and long-term cycling stability. A new multicolor electrochromic behavior is reported, with transitions from green to blue to purple, in conducting nickel-catecholate (Ni-CAT-1) MOFs. The system significantly improves cycling stability to 2000 cycles and reduces switching time to 3.6 s, both of which outperform most state-of-the-art MOF systems. An in-depth understanding of the coloring mechanism, particularly the interconversion among C─O, C─O • , and C = O groups is revealed. Water molecules play diverse roles in this redox process. Specifically, water molecules induce distortions in Ni─O bonds, facilitating C = O bond formation and expediting the oxidized coloring process, while also aiding the dissociation of ions from solvation complexes to enhance the reduction process. The practical applications of these findings are demonstrated by designing flexible multicolor electrochromic devices (FMEDs) for use in camouflage, flexible displays, and augmented reality (AR).}, archive = {J_ADVS}, author = {Qi Zhao and Jing Yang and Xingyang Wang and Wanwan Wang and Yulin Gao and Xue Chen and Jianguo Sun and Hao Yuan and Yu Liu and Jinwoo Park and Lewis Kien Juen Ting and Qing Wang and Pooi See Lee and Yanfeng Gao and Yong-Wei Zhang and John Wang}, doi = {10.1002/advs.202500678}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500678}, shortjournal = {Adv. Sci.}, title = {Water-enhanced multicolor electrochromism in nickel-catecholate MOFs}, volume = {12}, year = {2025}, }
• (2025). Fluorinated alkyl chains terminated polar glycol ether side chain for N-type organic thermoelectrics with enhanced performance and air stability. ADVS, 12(25), 2500571. (www)

  @article{ , abstract = {N-type organic thermoelectric materials with excellent device performance and air stability are critically important for practical applications in organic thermoelectric devices. However, the design and synthesis of air-stable n-type conductive materials with high electrical conductivities remain a significant challenge. In this paper, a new strategy is reported to enhance the thermoelectric performance and air stability of naphthalenediimide (NDI)-dialkoxybithiazole-based conjugated polymers by introducing fluorinated alkyl chains terminated polar glycol ether side chains into the NDI unit. After molecular doping with 4-(2,3-dihydro-1,3-dimethyl-1H-benzoimidazol-2-yl) phenyl)-N, N-dimethylbenzenamine (N-DMBI), the doped films of the fluorinated alkyl side-chain modified conjugated polymer exhibit higher electrical conductivity, thus resulting in a greater power factor; and better air stability compared to those of the unmodified polymer with the same conjugated backbone. The work provides insights into material design for the future development of air-stable n-type organic thermoelectrics.}, archive = {J_ADVS}, author = {Gang Ye and Yazhuo Kuang and Mingyu Ma and Xiantao Peng and Jian Liu}, doi = {10.1002/advs.202500571}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500571}, shortjournal = {Adv. Sci.}, title = {Fluorinated alkyl chains terminated polar glycol ether side chain for N-type organic thermoelectrics with enhanced performance and air stability}, volume = {12}, year = {2025}, }
• (2025). Active sites-enriched hierarchical weyl semimetal WTe2 nanowire arrays for highly efficient hydrogen evolution reaction. ADVS, 12(25), 2500516. (www)

  @article{ , abstract = {Weyl semimetal tungsten ditelluride (WTe 2 ), characterized by its high conductivity and robust topological surface state, possesses promising catalytic properties for electrochemical reactions. However, the synthesis of well-defined WTe 2 nanostructures has faced challenges, hindering their practical applications. This study introduces a new method for synthesizing Weyl semimetal WTe 2 nanowire arrays grown vertically on conductive carbon cloth. Through a selective synthesis process, WTe 2 and core–shell semiconductor-semimetal WO 3− x –WTe 2 nanowires are successfully fabricated via tellurization of WO 2.9 nanowires. To gain a comprehensive understanding of the structural, chemical, and catalytic properties of these nanowires, WO 2.9 nanowires are gradually converted to WO 3− x –WTe 2 and WTe 2 nanowires. The hierarchical structure of the WTe 2 nanowires greatly increases the number of active sites and promotes efficient charge transfer, resulting in exceptional electrochemical catalytic performance. In the hydrogen evolution reaction, WTe 2 nanowire arrays exhibit an exceptionally low Tafel slope of 49 mV dec −1 , as well as remarkable stability under both high and low current densities. These exceptional properties highlight the potential of WTe 2 nanowire arrays as highly effective electrochemical catalysts. It is expected that this facile synthesis approach will pave the way for the fabrication of well-structured Weyl semimetal nanowires, enabling further exploration of their intriguing properties and promising applications.}, archive = {J_ADVS}, author = {Hyeonkyeong Kim and Youngdong Yoo}, doi = {10.1002/advs.202500516}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500516}, shortjournal = {Adv. Sci.}, title = {Active sites-enriched hierarchical weyl semimetal WTe2 nanowire arrays for highly efficient hydrogen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). Accurate and noninvasive dysphagia assessment via a soft high-density sEMG electrode array conformal to the submental and infrahyoid muscles. ADVS, 12(25), 2500472. (www)

  @article{ , abstract = {Accurate, noninvasive dysphagia assessment is important for rehabilitation therapy but current clinical diagnostic methods are either invasive or subjective. Surface electromyography (sEMG) that monitors muscle activity during swallowing, offers a promising alternative. However, existing sEMG electrode arrays for dysphagia assessment remain challenging in combining the advantages of a large coverage area and strong compliance to the entire swallowing muscles. Here, we report a stretchable, breathable, large-area high-density sEMG (HD-sEMG) electrode array, which enables intimate contact to complex surface of the submental and infrahyoid muscles to detect high-fidelity HD-sEMG signals during swallowing. The electrode array features a 64-channel soft on-skin sensing array for comprehensive data capture, and a stiff connector for simple and reliable connection to an external acquisition setup. Systemically experimental studies revealed the easy operability of the soft HD-sEMG electrode array for effortless integration with the skin, as well as the excellent mechanical and electrical characteristics even subject to substantial skin deformations. By comparing HD-sEMG signals collected from 38 participants, three objective indicators for quantitative dysphagia evaluation were discussed. Finally, a machine learning model was developed to accurately and automatically classify the severity of dysphagia, and the factors affecting the recognition accuracy of the model were discussed in depth.}, archive = {J_ADVS}, author = {Weijie Hong and Lin Mao and Kai Lin and Chongyuan Huang and Yanyan Su and Shun Zhang and Chengjun Wang and Daming Wang and Jizhou Song and Zuobing Chen}, doi = {10.1002/advs.202500472}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500472}, shortjournal = {Adv. Sci.}, title = {Accurate and noninvasive dysphagia assessment via a soft high-density sEMG electrode array conformal to the submental and infrahyoid muscles}, volume = {12}, year = {2025}, }
• (2025). Hybrid series of carbon-vacancy electrodes for multi chemical vapors diagnosis using a residual multi-task model. ADVS, 12(25), 2500412. (www)

  @article{ , abstract = {Detecting individual gases with various sensors is a well-established field in gas sensing. However, substantial challenges and opportunities remain in the simultaneous detection and classification of multiple gases. Artificial intelligence (AI) integrated gas sensor systems effectively enable multi-gas detection using specialized algorithms. Nevertheless, these algorithms are prone to overfitting owing to their high model complexity; this study proposes a sensor array that engineers carbon vacancies in graphene oxide via metal ion doping and high-temperature reduction, enabling high-sensitivity, simultaneous detection of various gases at low temperatures (20 °C). By integrating an advanced artificial intelligence framework, the acquired electrical signals are transformed, and a multi-task learning (MTL) approach is applied to achieve instantaneous identification of four gas types and four-level concentrations. The proposed MTL framework demonstrates superior performance by effectively mitigating overfitting and improving generalization through feature sharing and mutual regularization between gas type classification and concentration estimation tasks. Experimental validation on vehicle exhaust gas fault diagnosis highlights the method's effectiveness and applicability in complex conditions, achieving 98.22% accuracy and 48% faster inference compared to traditional single-task models. This study provides a basis for developing more intelligent and adaptable sensor systems capable.}, archive = {J_ADVS}, author = {Tianci Liu and Yun Ji Hwang and Lu Zhang and Jongwoo Hong and Teajong Hwang and Seong Chan Jun}, doi = {10.1002/advs.202500412}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500412}, shortjournal = {Adv. Sci.}, title = {Hybrid series of carbon-vacancy electrodes for multi chemical vapors diagnosis using a residual multi-task model}, volume = {12}, year = {2025}, }
• (2025). Robustly repeatable, permeable, and multi-axially stretchable, adhesive bioelectronics with super-adaptive conductive suction cups for continuously deformable biosurfaces. ADVS, 12(25), 2500346. (www)

  @article{ , abstract = {Skin-integrated wearable bioelectronics offer immense potential for continuous health monitoring, diagnosis, and personalized therapy. However, robustly repeatable and permeable adhesive interfaces with omnidirectional stretchability for adaptability to continuously deforming skin surface remain a critical challenge and often results in issues such as delamination, void, and signal degradation. This study presents a highly adaptable bioelectronic device with a repeatable, robust and biocompatible adhesive interfaces designed for dynamic wet skin surfaces. The device integrates a conductive softened-double-layered octopus-inspired nanocomposites adhesive and kirigami metastructure (cs-OIA_k). The cs-OIA_k achieves skin-like softness, electrical stability ( ΔR/R 0 < 10, under 10 000 cycles) and omnidirectional stretchability (a maximum of 200%) to accommodate skin deformation. Additionally, the hierarchical structural design of cs-OIA_k enables repeatable robust adhesion (> 10 000 cycles) and vertical alignment to ensure reversible adhesion against dynamically deforming surface (−30% to 100%, depending on skin thickness, site, and age) without skin irritation. Based on these characteristics, the highly adaptable skin-adhesive bioelectronics are demonstrated to achieve reliable electrocardiogram (ECG) and electromyogram (EMG) signal measurements even under shoulder movements with extreme skin deformation. This approach utilizing multi-axially stretchable, repeatable robust adhesives, permeable and biocompatible bioelectronics provides new insights for the development of advanced wearable systems and human–machine interfaces.}, archive = {J_ADVS}, author = {Gyun Ro Kang and Gui Won Hwang and Dohyun Lim and Seung Hwan Jeon and Minwoo Song and Chan-Hwa Hong and Hye Jin Kim and Changhyun Pang}, doi = {10.1002/advs.202500346}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2500346}, shortjournal = {Adv. Sci.}, title = {Robustly repeatable, permeable, and multi-axially stretchable, adhesive bioelectronics with super-adaptive conductive suction cups for continuously deformable biosurfaces}, volume = {12}, year = {2025}, }
• (2025). Immunotyping the tumor microenvironment reveals molecular heterogeneity for personalized immunotherapy in cancer. ADVS, 12(25), 2417593. (www)

  @article{ , abstract = {The tumor microenvironment (TME) significantly influences cancer prognosis and therapeutic outcomes, yet its composition remains highly heterogeneous, and currently, no highly accessible, high-throughput method exists to define it. To address this complexity, the TMEclassifier, a machine-learning tool that classifies cancers into three distinct subtypes: immune Exclusive (IE), immune Suppressive (IS), and immune Activated (IA), is developed. Bulk RNA sequencing categorizes patient samples by TME subtype, and in vivo mouse model validates TME subtype differences and differential responses to immunotherapy. The IE subtype is marked by high stromal cell abundance, associated with aggressive cancer phenotypes. The IS subtype features myeloid-derived suppressor cell infiltration, intensifying immunosuppression. In contrast, the IA subtype, often linked to EBV/MSI, exhibits robust T-cell presence and improved immunotherapy response. Single-cell RNA sequencing is applied to explore TME cellular heterogeneity, and in vivo experiments demonstrate that targeting IL-1 counteracts immunosuppression of IS subtype and markedly improves its responsiveness to immunotherapy. TMEclassifier predictions are validated in this prospective gastric cancer cohort (TIMES-001) and other diverse cohorts. This classifier could effectively stratify patients, guiding personalized immunotherapeutic strategies to enhance precision and overcome resistance.}, archive = {J_ADVS}, author = {Dongqiang Zeng and Yunfang Yu and Wenjun Qiu and Qiyun Ou and Qianqian Mao and Luyang Jiang and Jianhua Wu and Jiani Wu and Huiyan Luo and Peng Luo and Wenchao Gu and Na Huang and Siting Zheng and Shaowei Li and Yonghong Lai and Xiatong Huang and Yiran Fang and Qiongzhi Zhao and Rui Zhou and Huiying Sun and Wei Zhang and Jianping Bin and Yulin Liao and Masami Yamamoto and Tetsuya Tsukamoto and Sachiyo Nomura and Min Shi and Wangjun Liao}, doi = {10.1002/advs.202417593}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2417593}, shortjournal = {Adv. Sci.}, title = {Immunotyping the tumor microenvironment reveals molecular heterogeneity for personalized immunotherapy in cancer}, volume = {12}, year = {2025}, }
• (2025). Sustainable high-performance aqueous batteries enabled by optimizing electrolyte composition. ADVS, 12(25), 2417587. (www)

  @article{ , abstract = {Lithium-free aqueous batteries (LFABs) offer a sustainable alternative to lithium-ion batteries for large-scale energy storage, addressing issues like material scarcity and flammability. However, their economic viability is limited by low energy density and cycle life due to the narrow electrochemical stability window of water and active material dissolution. High-concentration water-in-salt electrolytes typically used to tackle these issues are expensive and potentially hazardous. This work presents a novel, cost-efficient electrolyte design using safe salts at lower concentrations. The influence of different cation species on the copper hexacyanoferrate cathode and polyimide anode is systematically explored, optimizing the electrolyte for improved cell voltage and cycling stability. The resulting battery, with a 1.8 mol kg ⁻1 MgCl 2 + 1.8 mol kg⁻ 1 KCl aqueous electrolyte, achieves a competitive energy density of 48 Wh kg⁻¹ and 95% efficiency. It also shows 70% capacity retention even at extremely high (dis-)charge rates of 50 C and a maximum specific power of over 10000 W kg⁻¹, indicating its strong potential for supercapacitor applications. Utilizing exclusively inexpensive and safe salts, this work significantly advances the practical application of low-cost LFABs for large-scale energy storage.}, archive = {J_ADVS}, author = {Raphael L. Streng and Samuel Reiser and Anatoliy Senyshyn and Sabrina Wager and Johannes Sterzinger and Peter Schneider and David Gryc and Mian Zahid Hussain and Aliaksandr S. Bandarenka}, doi = {10.1002/advs.202417587}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2417587}, shortjournal = {Adv. Sci.}, title = {Sustainable high-performance aqueous batteries enabled by optimizing electrolyte composition}, volume = {12}, year = {2025}, }
• (2025). Manipulating charge dynamics in carbon nitride by carbon dot doping for efficient photocatalysis. ADVS, 12(25), 2417390. (www)

  @article{ , abstract = {Graphitic carbon nitride (g-C 3 N 4 ), a prominent metal-free semiconductor photocatalyst, faces limitations due to its high exciton binding energy. While significant efforts have been focused on optimizing charge-carrier processes, the interplay of exciton and free carrier in this system have received less attention. Herein, this density-functional theory (DFT) and time-dependent DFT calculations demonstrate that carbon dot-functionalized g-C 3 N 4 (g-C 3 N 4 /CD), synthesized via a facile thermal polymerization, shifts the excited state from localized to charge transfer characteristics. The g-C 3 N 4 /CD exhibits reduced exciton binding energy from 41.0 to 24.6 meV, as shown by temperature-dependent photoluminescence spectroscopy. Particularly, g-C 3 N 4 /CD-10 (10 wt.% CD solution in precursors) achieves a 3-fold increase in the photodegradation rate ( k = 0.020 min⁻¹) of an emerging environmental pollutant, levofloxacin (LEV), under 10 W LED light. Enhanced photocatalytic performances correlate with optimized band structure and efficient charge transport, as confirmed by photophysical and photoelectrochemical analyses. Although the excited state lifetime in g-C 3 N 4 /CD is slightly reduced compared to pristine g-C 3 N 4 , photocatalytic activity remains unaffected, underscoring the critical role of charge excited state in enhancing photocatalytic efficiency. This work offers insights onto the potential of manipulating charge transfer excited state dynamics for improved g-C 3 N 4 -based photocatalysis in environmental applications.}, archive = {J_ADVS}, author = {Lingfeng Ouyang and Maggie Ng and Zhang-Hong Zhou and Hao Wu and Man-Chung Tang and Season Si Chen}, doi = {10.1002/advs.202417390}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2417390}, shortjournal = {Adv. Sci.}, title = {Manipulating charge dynamics in carbon nitride by carbon dot doping for efficient photocatalysis}, volume = {12}, year = {2025}, }
• (2025). Collaborative duality of CircGLIS3(2) RNA and protein in human wound repair. ADVS, 12(25), 2416784. (www)

  @article{ , abstract = {The discovery of an increasing number of translatable circular RNAs (circRNAs) raises the question of whether their coding and non-coding functions can coexist within the same cell. This study profiles the dynamic expression of circRNAs during human skin wound healing. CircGLIS3(2) is identified, a circRNA whose levels transiently rise in dermal fibroblasts of acute wounds and are abnormally overexpressed in keloids, a fibrotic skin condition. Injury signals such as IL-1α, TGF-β, hypoxia, and ER stress induce both expression and cap-independent translation of CircGLIS3(2). The RNA form of CircGLIS3(2) activates fibroblasts into matrix-secreting cells, while its encoded protein promotes cell proliferation, collectively enhancing wound repair. Mechanistically, CircGLIS3(2) RNA stabilizes the cytoplasmic protein PCOLCE, while its protein binds to BTF3 in the nucleus. Both the RNA and protein are essential for wound closure in human and murine models. CircGLIS3(2) ’s bifunctional nature expands its functional spectrum, improving cellular adaptability during environmental changes and offering a promising therapeutic target for wound repair and scar reduction.}, archive = {J_ADVS}, author = {Guanglin Niu and Maria A. Toma and Jennifer Geara and Xiaowei Bian and Yongjian Chen and Lihua Luo and Qizhang Wang and Yunting Xiao and Manika Vij and Minna Piipponen and Zhuang Liu and Sho Oasa and Letian Zhang and Dörte Schlesinger and Ákos Végvári and Dongqing Li and Aoxue Wang and Vladana Vukojević and Simon J Elsässer and Pehr Sommar and Ning Xu Landén}, doi = {10.1002/advs.202416784}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2416784}, shortjournal = {Adv. Sci.}, title = {Collaborative duality of CircGLIS3(2) RNA and protein in human wound repair}, volume = {12}, year = {2025}, }
• (2025). Multi-factor optimization of nickel foam flow fields: Insights into structural and surface modifications for high-performance PEMFCs. ADVS, 12(25), 2416770. (www)

  @article{ , abstract = {The performance of proton exchange membrane fuel cells (PEMFC) can be significantly influenced by the physical properties of the flow field design. In this study, nickel foam with varying physical parameters—compression (porosity), pore size, hydrophobicity, and anti-corrosion surface treatments—are systematically investigated to evaluate their influence on PEMFC electrochemical performance, water management, and corrosion resistance. The results reveal that moderate compression (67%), corresponding to a porosity of 85%, offers the optimal balance between electrical conductivity and mass transport, achieving the highest power density of 0.918 W cm −2 and a conductivity formation factor 23% higher than uncompressed samples. Excessive compression may cause ligament fractures and occluded cavities, reducing water management capabilities, and increasing parasitic loss and mass transport resistance. Furthermore, smaller pore sizes result in increased concentration losses, primarily due to higher fluid resistance, complex diffusion pathways, and water retention. Hydrophobic surface modification via polytetrafluoroethylene increased water removal efficiency but at the expense of ohmic losses, with excessive loading hindering water transfer and blocking pores. Among various anti-corrosion coatings, graphene emerged as the optimal choice, providing superior hydrophobicity, corrosion resistance, and electrical conductivity. These findings offer valuable insights for enhancing PEMFC performance and durability.}, archive = {J_ADVS}, author = {Siyuan Wu and Chasen Tongsh and Xinmin Ruan and Qing Du and Jae Wan Park and Kui Jiao}, doi = {10.1002/advs.202416770}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2416770}, shortjournal = {Adv. Sci.}, title = {Multi-factor optimization of nickel foam flow fields: Insights into structural and surface modifications for high-performance PEMFCs}, volume = {12}, year = {2025}, }
• (2025). CNPY2 aggravates renal tubular cell ferroptosis in diabetic nephropathy by regulating PERK/ATF4/CHAC1 pathway and MAM integrity. ADVS, 12(25), 2416441. (www)

  @article{ , abstract = {Ferroptosis is emerging as a novel mechanism for understanding renal tubular injury in diabetic nephropathy (DN). The mitochondria-associated endoplasmic reticulum membrane (MAM) plays a crucial role in the regulation of numerous cellular processes, including mitochondrial dysfunction and endoplasmic reticulum (ER) stress (ERS). However, the exact mechanism underlying ferroptosis and MAM in DN remains unclear. In this study, we identified that canopy FGF signaling regulator 2 (CNPY2) is upregulated in the renal tubules of DN. Downregulation of CNPY2 alleviated ferroptosis and improved MAM integrity in the renal tubular epithelial cells of db/db mice. Conversely, CNPY2 overexpression aggravated tubular injury in DN by accelerating ferroptosis and disrupting MAM formation. Mechanistically, CNPY2 activated the PERK/ATF4/CHAC1 signaling pathway to facilitate ferroptosis, thus contributing to tubular injury in DN. These findings highlight the critical role of CNPY2 in modulating ferroptosis and MAM formation in DN progression, and suggest that CNPY2 is a feasible therapeutic target for DN.}, archive = {J_ADVS}, author = {Jingfang Chen and Dongwei Liu and Lei Lei and Ting Liu and Shaokang Pan and Hui Wang and Yong Liu and Yingjin Qiao and Zhangsuo Liu and Qi Feng}, doi = {10.1002/advs.202416441}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2416441}, shortjournal = {Adv. Sci.}, title = {CNPY2 aggravates renal tubular cell ferroptosis in diabetic nephropathy by regulating PERK/ATF4/CHAC1 pathway and MAM integrity}, volume = {12}, year = {2025}, }
• (2025). AhR-dependent induction of β-defensin 1 in colonic epithelial cells regulates cross-talk between gut microbiota and immune response leading to attenuation of colitis. ADVS, 12(25), 2416324. (www)

  @article{ , abstract = {The aryl hydrocarbon receptor (AhR) acts as a critical signaling hub that connects immune cells, food and environmental cues, and microbiota to regulate intestinal homeostasis. In the current study, the role of AhR in the regulation of an antimicrobial peptide, β-defensin1 (BD-1) is investigated to control colitis. Human patients with ulcerative colitis (UC) and Crohn's disease (CD), and mice with three different models of colitis, express a significant decrease in the expression of BD-1 in colonic epithelial cells (CECs). Dietary and environmental AhR ligands induce the expression of BD-1 in CECs through the activation of two dioxin-responsive elements (DREs) expressed on its promoter. AhR ligands attenuate colitis in wild-type (WT) mice while inducing BD-1. However, AhR ligands fail to induce BD-1 and protect mice from colitis when there is an intestinal epithelial cell (IEC)-specific deletion of AhR. Blocking BD1 in vivo using antibodies prevents the ability of AhR ligands to ameliorate colitis, restore dysbiosis, and attenuate colonic inflammation. The current study identifies a novel pathway involving dietary, environmental, and endogenous AhR ligands to induce the antimicrobial peptide BD-1 in IECs, which in turn, plays a critical role in the regulation of intestinal homeostasis.}, archive = {J_ADVS}, author = {Manikandan Palrasu and Amarnath Marudamuthu and Khadija Kakar and Hamida Hamida and Shruthi Thada and Rohan Gupta and Kiesha Wilson and Taylor Carter and Yin Zhong and Archana Saxena and Xiaoming Yang and Narendra Singh and Philip Brandon Busbee and Jie Li and Monica Garcia-Buitrago and Prakash Nagarkatti and Mitzi Nagarkatti}, doi = {10.1002/advs.202416324}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2416324}, shortjournal = {Adv. Sci.}, title = {AhR-dependent induction of β-defensin 1 in colonic epithelial cells regulates cross-talk between gut microbiota and immune response leading to attenuation of colitis}, volume = {12}, year = {2025}, }
• (2025). Advancements in bio-integrated flexible electronics for hemodynamic monitoring in cardiovascular healthcare. ADVS, 12(25), 2415215. (www)

  @article{ , abstract = {Cardiovascular diseases (CVDs) remain the leading cause of global mortality, highlighting the urgent need for effective monitoring and prevention strategies. The rapid advancement of flexible sensing technology and the development of conformal sensors have attracted significant attention due to their potential for continuous, real-time assessment of cardiovascular health over extended periods. This review outlines recent advancements in bio-integrated flexible electronics designed for hemodynamic monitoring and broader CVD healthcare applications. It introduces key physiological indicators relevant to hemodynamics, including heart rate, blood pressure, blood flow velocity, and cardiac output. Next, it discusses flexible bio-integrated electronics engineering strategies, such as working principles and configuration designs. Various non-invasive and invasive bio-integrated devices for monitoring these hemodynamic indicators are then presented. Additionally, the review highlights the role of artificial intelligence algorithms and their practical applications in bio-integrated electronics for hemodynamic detection. Finally, it proposes future directions and addresses potential challenges in the field.}, archive = {J_ADVS}, author = {Ke Huang and Zhiqiang Ma and Bee Luan Khoo}, doi = {10.1002/advs.202415215}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2415215}, shortjournal = {Adv. Sci.}, title = {Advancements in bio-integrated flexible electronics for hemodynamic monitoring in cardiovascular healthcare}, volume = {12}, year = {2025}, }
• (2025). Isoquercitrin alleviates diabetic nephropathy by inhibiting STAT3 phosphorylation and dimerization. ADVS, 12(25), 2414587. (www)

  @article{ , abstract = {At the convergence point of multiple cytokine signals, signal transducer and activator of transcription 3 (STAT3) is a highly promising therapeutic target for diabetic nephropathy. Isoquercitrin, a natural small-molecule inhibitor of STAT3, may have beneficial effects on diabetic nephropathy; however, the underlying mechanism remains unclear. Isoquercitrin significantly mitigated renal inflammation and fibrosis by inhibiting STAT3 activity in mice with diabetic nephropathy. Moreover, STAT3 is a direct molecular target of isoquercitrin, which as corroborated by tight and stable noncovalent binding between them. This interaction is mechanistically supported by the affinity of isoquercitrin for the Ser668–Gln635–Gln633 region within the pY+1 binding pocket of the SH2 domain. This binding obstructs pivotal processes like STAT3 phosphorylation and dimerization, thereby suppressing its transcriptional function. Finally, a kidney-targeted nanocarrier, Iso@PEG-GK, is developed to load isoquercitrin, thus enhancing its therapeutic precision for diabetic nephropathy. Iso@PEG-GK significantly improved the absorption and renal distribution of isoquercitrin. This study is the first to demonstrate that isoquercitrin exerts a significant protective effect against diabetic nephropathy and may provide a novel therapeutic drug for this disease.}, archive = {J_ADVS}, author = {Chen Xuan and Donghui Chen and Shuangna Zhang and Chaofan Li and Qingyun Fang and Dinghua Chen and Jiabao Liu and Xin Jiang and Yingjie Zhang and Wanjun Shen and Guangyan Cai and Xiangmei Chen and Ping Li}, doi = {10.1002/advs.202414587}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2414587}, shortjournal = {Adv. Sci.}, title = {Isoquercitrin alleviates diabetic nephropathy by inhibiting STAT3 phosphorylation and dimerization}, volume = {12}, year = {2025}, }
• (2025). Neuraminidase 1 exacerbated glycolytic dysregulation and cardiotoxicity by destabilizing SIRT1 through interactions with NRF2 and HIF1α. ADVS, 12(25), 2414504. (www)

  @article{ , abstract = {Despite significant therapeutic advances, cumulative DOX-induced cardiotoxicity (DIC) events remain unacceptably high. Recent evidence has underscored the critical role of impaired glycolytic metabolism in cardiovascular damage. Neuraminidase 1 (NEU1), a member of the neuraminidase family, catalyzes the hydrolysis of terminal sialic acids from glycoconjugates. Here, it is aimed to characterize the role of NEU1 on defective glycolysis during DIC. Mouse models with cardiac-specific genetic modifications of Neu1 , Nrf2 , and Sirt1 underwent functional analyses, and RNA sequencing to clarify NEU1's role in glycolytic metabolism during DIC. It is discovered that NEU1 is highly expressed after DOX exposure and positively correlated with defective glycolysis phenotypes. Cardiomyocyte-specific deficiency of Neu1 ameliorated impaired glycolytic metabolism and DIC, whereas overexpression of Neu1 in cardiomyocytes exacerbated these pathological phenotypes. Mechanistically, the upregulation of Neu1 is attributed to HIF1α’s transcriptional repression, which necessitated the collaboration of NRF2. Additionally, the C-terminal region of NEU1 physically interacted with SIRT1, facilitating its lysosomal-mediated degradation and contributing to the aberrant glycolytic phenotype. The pharmacological or genetic manipulation of NRF2 and HIF1α remarkably abolished DOX-induced NEU1 upregulation, compromised glucose metabolism, and DIC progression. Collectively, NEU1 as a key regulator of cardiac glycolysis is established, offering new therapeutic avenues for DIC through maintaining metabolic flexibility.}, archive = {J_ADVS}, author = {Ting Gao and Yufeng Tang and Tao Zeng and Jie Wang and Xiaohui Zhang and Qingbo Liu and Xun Guan and Xinyu Tang and Guangping Lu and Jiahao Li and Mingrui Liu and Dongmei Zhang and Sixuan Lv and Junlian Gu}, doi = {10.1002/advs.202414504}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2414504}, shortjournal = {Adv. Sci.}, title = {Neuraminidase 1 exacerbated glycolytic dysregulation and cardiotoxicity by destabilizing SIRT1 through interactions with NRF2 and HIF1α}, volume = {12}, year = {2025}, }
• (2025). Accurate delivery of mesenchymal stem cell spheroids with platelet-rich fibrin shield: Enhancing survival and repair functions of sp-MSCs in diabetic wound healing. ADVS, 12(25), 2413430. (www)

  @article{ , abstract = {Diabetic wound is a significant clinical challenge, and stem cell therapy has shown great potential. This study explores the role of mesenchymal stem cell (MSC) spheroids (Sp-MSCs) in healing diabetic wounds and the use of autologous plasma-rich platelet fibrin (PRF) as a scaffold for Sp-MSCs. Through activation of the coagulation system, PRF offers a protective fibrin shield for Sp-MSCs to promote the rapid recovery migration and proliferation of MSCs while maintaining the activity of Sp-MSCs in an inflammatory overload environment by activating the related genes of Integrin-β1-vascular endothelial growth factor (VEGF), and Wnt/β-catenin pathways. The inclusion of Sp-MSCs accelerates the gelation of PRF and results in improved mechanical strength. Additionally, PRF enhances the repair function of Sp-MSCs, creating a favorable microenvironment for angiogenesis. In the wound model of diabetic mice, the combination of PRF with Sp-MSCs accelerates wound healing. Results show that this combination significantly promotes wound repair and regulates the immune microenvironment. The study suggests that PRF is a promising bio-derived scaffold for stem cell applications in diabetic wounds, offering new directions for stem cell therapy and biomimetic scaffold material development.}, archive = {J_ADVS}, author = {Jinglve Zhang and Wenqing Xu and Yutian Xiao and Dingheng Su and Yusheng He and Huohong Yang and Yixin Xie and Xiaofang Wang and Ren-He Xu and Shaorong Lei and Dingyu Wu}, doi = {10.1002/advs.202413430}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2413430}, shortjournal = {Adv. Sci.}, title = {Accurate delivery of mesenchymal stem cell spheroids with platelet-rich fibrin shield: Enhancing survival and repair functions of sp-MSCs in diabetic wound healing}, volume = {12}, year = {2025}, }
• (2025). Key connectomes and synaptic-compartment-specific risk genes drive pathological α-synuclein spreading. ADVS, 12(25), 2413052. (www)

  @article{ , abstract = {Previous studies have suggested that pathological α-synuclein (α-Syn) mainly transmits along the neuronal network, but several key questions remain unanswered: 1) How many and which connections in the connectome are necessary for predicting the progression of pathological α-Syn? 2) How to identify risk genes that affect pathology spreading functioning at presynaptic or postsynaptic regions, and are these genes enriched in different cell types? Here, these questions are addressed with novel mathematical models. Strikingly, the spreading of pathological α-Syn is predominantly determined by the key subnetworks composed of only 2% of the strongest connections in the connectome. Genes associated with the selective vulnerability of brain regions to pathological α-Syn transmission are further analyzed to distinguish those functioning at presynaptic versus postsynaptic regions. Those risk genes are significantly enriched in microglial cells of presynaptic regions and neurons of postsynaptic regions. Gene regulatory network analyses are then conducted to identify “key drivers” of genes responsible for selective vulnerability and overlapping with Parkinson's disease risk genes. By identifying and discriminating between key gene mediators of transmission operating at presynaptic and postsynaptic regions, this study has demonstrated for the first time that these are functionally distinct processes.}, archive = {J_ADVS}, author = {Yuanxi Li and Justin Torok and Shujing Zhang and Jessica Ding and Ning Wang and Courtney Lau and Shruti Kulkarni and Chaitali Anand and Julie Tran and Michael Cheng and Claire Lo and Binbin Lu and Yanzi Sun and Robert Damoiseaux and Xia Yang and Ashish Raj and Chao Peng}, doi = {10.1002/advs.202413052}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2413052}, shortjournal = {Adv. Sci.}, title = {Key connectomes and synaptic-compartment-specific risk genes drive pathological α-synuclein spreading}, volume = {12}, year = {2025}, }
• (2025). Intracellular formation of synthetic peptide nanostructures causes mitochondrial disruption and cell death in tumor spheroids. ADVS, 12(25), 2412606. (www)

  @article{ , abstract = {Supramolecular assemblies found in nature demonstrate the concept of creating functionality through structure formation. In recent years, these complex natural architectures have inspired the development of materials for the formation of synthetic nanostructures within living cells. These intracellular assemblies have the potential to modulate cellular processes, yet their specific effects on cellular metabolism and 3D cell networks, such as tumor spheroids, still remain underexplored. Herein, the study correlates the glutathione-induced formation of synthetic nanostructures inside MDA-MB-231 triple-negative breast cancer cells to the metabolic disruption and mitochondrial degradation observed in 2D cell culture, as well as to cell death and size decrease in a 3D tumor spheroid model. In 2D cell culture, material-cell interactions are examined through live-cell imaging and by quantifying changes in mitochondrial respiration. By studying the interplay between glutathione-responsive cytosolic peptide assembly and the implications on the integrity of the mitochondrial network, as well as on 3D cell networks, the work advances the understanding of how synthetic intracellular nanofibers impact vital functions of living cells.}, archive = {J_ADVS}, author = {Sarah Chagri and Konrad Maxeiner and Maria J. S. A. Silva and Lisa Förch and Julian Link and Patrick Roth and Raphael Meyer and Jana Fetzer and Anke Kaltbeitzel and Ingo Lieberwirth and Katharina Landfester and Manfred Wagner and David Y.W. Ng and Tanja Weil}, doi = {10.1002/advs.202412606}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2412606}, shortjournal = {Adv. Sci.}, title = {Intracellular formation of synthetic peptide nanostructures causes mitochondrial disruption and cell death in tumor spheroids}, volume = {12}, year = {2025}, }
• (2025). The CRL7FBXW8 complex controls the mammary stem cell compartment through regulation of NUMB levels. ADVS, 12(25), 2405812. (www)

  @article{ , abstract = {NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto-oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss of function (LOF), mediated by various molecular mechanisms, is a frequent and causal event. Herein, it is established that loss of NUMB protein, resulting from protein hyper-degradation, is the prevalent mechanism of NUMB LOF in BC. Through an RNAi-based screening, the CRL7 FBXW8 complex is identified as the E3 ligase complex responsible for NUMB hyper-degradation in BC. Genetic and pharmacological inhibition of CRL7 FBXW8 rescues the transformation-related phenotypes induced by NUMB LOF in BC cell lines and in patient-derived xenografts. These effects are directly dependent on the restoration of NUMB protein levels. Thus, enhanced CRL7 FBXW8 activity, through its interference with the tumor suppressor activity of NUMB, is a causal alteration in BC, suggesting it as a potential therapeutic target for precision medicine.}, archive = {J_ADVS}, author = {Simone Sabbioni and Maria Grazia Filippone and Letizia Amadori and Stefano Confalonieri and Roberta Bonfanti and Stefano Capoano and Ivan Nicola Colaluca and Stefano Freddi and Giovanni Bertalot and Giovanni Fagà and Elisa Zagarrí and Mario Varasi and Rosalind Helen Gunby and Ciro Mercurio and Salvatore Pece and Pier Paolo Di Fiore and Daniela Tosoni}, doi = {10.1002/advs.202405812}, journal = {Advanced Science}, month = {7}, number = {25}, pages = {2405812}, shortjournal = {Adv. Sci.}, title = {The CRL7FBXW8 complex controls the mammary stem cell compartment through regulation of NUMB levels}, volume = {12}, year = {2025}, }
• (2025). Real-time wireless detection of heavy metal ions using a self-powered triboelectric nanosensor integrated with an autonomous thermoelectric generator-powered robotic system (Adv. sci. 24/2025). ADVS, 12(24), 2570187. (www)

  @article{ , archive = {J_ADVS}, author = {Yan-Tsz Huang and Arshad Khan and Anindita Ganguly and Kuldeep Kaswan and Sreerag Suresh and Yu-Ying Cheng and Kuan-Ming Lee and Jui-Han Yu and Zong-Hong Lin}, doi = {10.1002/advs.202570187}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2570187}, shortjournal = {Adv. Sci.}, title = {Real-time wireless detection of heavy metal ions using a self-powered triboelectric nanosensor integrated with an autonomous thermoelectric generator-powered robotic system (Adv. sci. 24/2025)}, volume = {12}, year = {2025}, }
• (2025). Tailoring piezoelectric nanogenerators and microdevices for cellular excitation: Impact of size and morphology (Adv. sci. 24/2025). ADVS, 12(24), 2570186. (www)

  @article{ , archive = {J_ADVS}, author = {Laura Lefaix and Marc Navarro and Carme Nogués and Andreu Blanquer and Gonzalo Murillo}, doi = {10.1002/advs.202570186}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2570186}, shortjournal = {Adv. Sci.}, title = {Tailoring piezoelectric nanogenerators and microdevices for cellular excitation: Impact of size and morphology (Adv. sci. 24/2025)}, volume = {12}, year = {2025}, }
• (2025). Advances in electrical materials for bone and cartilage regeneration: Developments, challenges, and perspectives (Adv. sci. 24/2025). ADVS, 12(24), 2570185. (www)

  @article{ , archive = {J_ADVS}, author = {Yubin Yao and Xi Cui and Shenglong Ding and Ketao Wang and Mingzhu Zhang}, doi = {10.1002/advs.202570185}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2570185}, shortjournal = {Adv. Sci.}, title = {Advances in electrical materials for bone and cartilage regeneration: Developments, challenges, and perspectives (Adv. sci. 24/2025)}, volume = {12}, year = {2025}, }
• (2025). Nanoenergy and nanosystems advance the development of healthcare. ADVS, 12(24), 2507393. (www)

  @article{ , archive = {J_ADVS}, author = {Zhou Li and Heyi Wei}, doi = {10.1002/advs.202507393}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2507393}, shortjournal = {Adv. Sci.}, title = {Nanoenergy and nanosystems advance the development of healthcare}, volume = {12}, year = {2025}, }
• (2025). A dual-modal wearable pulse detection system integrated with deep learning for high-accuracy and low-power sleep apnea monitoring. ADVS, 12(24), 2501750. (www)

  @article{ , abstract = {Despite being a serious health condition that significantly increases cardiovascular and metabolic disease risks, sleep apnea syndrome (SAS) remains largely underdiagnosed. While polysomnography (PSG) remains the gold standard for diagnosis, its clinical application is limited by high costs, complex setup requirements, and sleep quality interference. Although wearable devices using photoplethysmography (PPG) have shown promise in SAS detection, their continuous operation demands substantial power consumption, hindering long-term monitoring capabilities. Here, a dual-modal wearable system is presented integrating a piezoelectric nanogenerator (PENG) and PPG sensor with a biomimetic fingertip structure for SAS detection. A two-stage detection strategy is adopted where the self-powered PENG performs continuous preliminary screening, activating the PPG sensor only when suspicious events are detected. Combined with a Vision Transformer-based deep learning model, the high-accuracy configuration achieves 99.59% accuracy, while the low-power two-stage approach maintained 94.95% accuracy. This dual-modal wearable pulse detection system provides a practical solution for long-term SAS monitoring, overcoming the limitations of traditional PSG while maintaining high detection accuracy. The system's versatility in both home and clinical settings offers the potential for improving early detection rates and treatment outcomes for SAS patients.}, archive = {J_ADVS}, author = {Jia Wang and Jiangtao Xue and Yang Zou and Yuxin Ma and Junhan Xu and Yanming Li and Fei Deng and Yiqian Wang and Kai Xing and Zhou Li and Tong Zou}, doi = {10.1002/advs.202501750}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2501750}, shortjournal = {Adv. Sci.}, title = {A dual-modal wearable pulse detection system integrated with deep learning for high-accuracy and low-power sleep apnea monitoring}, volume = {12}, year = {2025}, }
• (2025). Nanogenerator neuromodulation to enable locomotion rehabilitation for spinal cord injury via epidural electrical stimulation. ADVS, 12(24), 2501425. (www)

  @article{ , abstract = {Spinal cord injury (SCI) is a severe neurological disease, often accompanied by impaired lower limb motor function and muscle atrophy. Epidural electrical stimulation (EES) has been demonstrated promising for SCI therapy in ways of rehabilitation by facilitating the recovery of lower limb motor abilities. However, EES necessitates a considerable consumption of electrical energy and exhibits large individual differences in treatment. Nanogenerators (NGs) based on a novel power generation technology, are capable of transforming mechanical energy into electrical power. This mechanic-driven electrical stimulation has been reported effective in several types of neuromodulations, but not in EES to enable SCI rehabilitation. This study explores the efficacy of a hybrid-NG (H-NG) to elicit hindlimb locomotion in rats via EES on the spinal cord, in comparison with a commercial stimulus generator (SG). The results reveal that H-NG can activate the spinal cord and induce hindlimb locomotion with much lower electrical parameters and much smaller individual differences than SG. In addition, benefiting from the miniature size of the H-NG, an implantable EES system is constructed in vivo, enabling a self-driven and rational-controlled EES pattern. The proposed H-NG-based EES system provides a new strategy for optimized and personalized treatment for SCI patients.}, archive = {J_ADVS}, author = {Cong Li and Yizhu Shan and Shihao Zheng and Puchuan Tan and Yuan Bai and Engui Wang and Lingling Xu and Ruizeng Luo and Shengyu Chao and Jing Huang and Pengyu Ren and Zhou Li and Hongqing Feng}, doi = {10.1002/advs.202501425}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2501425}, shortjournal = {Adv. Sci.}, title = {Nanogenerator neuromodulation to enable locomotion rehabilitation for spinal cord injury via epidural electrical stimulation}, volume = {12}, year = {2025}, }
• (2025). Novel electroactive therapeutic platforms for cardiac arrhythmia management. ADVS, 12(24), 2500061. (www)

  @article{ , abstract = {Electroactive platforms have gained significant attention for their ability to convert various types of energy into electrical signals, offering promising applications in diverse biomedical fields. In cardiovascular care, these platforms are increasingly valued for their innovative solutions in managing cardiac functions and disorders. By regulating electrical activity in the heart, electroactive platforms offer novel methods for managing abnormal heart rhythms. This review explores the latest advancements in electroactive systems, categorizing them based on their energy sources and mechanisms, such as self-powered and conductive systems. It also highlights their applications in arrhythmia management, including monitoring, intervention, pacing, and repairing. Finally, the challenges, limitations, and future opportunities for clinical translation of these technologies are discussed.}, archive = {J_ADVS}, author = {Juwei Yang and Longfei Li and Yiran Hu and Zhou Li and Wei Hua}, doi = {10.1002/advs.202500061}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2500061}, shortjournal = {Adv. Sci.}, title = {Novel electroactive therapeutic platforms for cardiac arrhythmia management}, volume = {12}, year = {2025}, }
• (2025). Tailoring piezoelectric nanogenerators and microdevices for cellular excitation: Impact of size and morphology. ADVS, 12(24), 2415028. (www)

  @article{ , abstract = {The use of piezoelectric devices as wireless electrical stimulators is an emerging research topic. In this study, piezoelectric microdevices, consisting of ZnO nanosheets (NSs) functioning as piezoelectric nanogenerators (NGs) grown on top of silicon microparticles, to electrically stimulate cell are designed. The morphology of the ZnO NSs is optimized by tuning the thickness of the aluminum nitride (AlN) catalyst layer and adjusting the growth duration. ZnO NSs grown on thinner AlN layers (≤ 200 nm) and subjected to 9 h of hydrothermal growth exhibit the most suitable characteristics for cell stimulation, balancing crystal size, and electric field generation. The generation of a local electric field capable of exciting osteoblast cells is inferred from finite element simulations and intracellular calcium influx measurements. The internalization rate of silicon microdevices of varying sizes (3 × 3, 6 × 10, 12 × 18 µm 2 ) by osteosarcoma (Saos-2) and primary human osteoblast (hOB) cells is assessed. The results show that smaller devices have higher internalization rates, particularly in tumoral Saos-2 cells, while primary cells exhibit minimal internalization (< 10%) across all particle sizes. This study presents an optimized piezoelectric microdevice, based on a scalable and customizable fabrication process, for minimally invasive bioelectronic applications, offering accurate electrical cell stimulation while minimizing unwanted internalization.}, archive = {J_ADVS}, author = {Laura Lefaix and Marc Navarro and Carme Nogués and Andreu Blanquer and Gonzalo Murillo}, doi = {10.1002/advs.202415028}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2415028}, shortjournal = {Adv. Sci.}, title = {Tailoring piezoelectric nanogenerators and microdevices for cellular excitation: Impact of size and morphology}, volume = {12}, year = {2025}, }
• (2025). Microneedles at the forefront of next generation theranostics. ADVS, 12(24), 2412140. (www)

  @article{ , abstract = {Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments and multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devices to sophisticated diagnostic and therapeutic platforms. Microneedles enhance access to biomarkers via interstitial fluid, enabling real-time monitoring of physiological conditions, such as glucose and hormone levels, thus facilitating continuous health tracking. The evolution of microneedle design from solid to dissolvable forms broadens their utility from mere drug delivery to complex sensing and therapeutic applications, including insulin delivery for diabetes management, vaccination, and gene therapy. This paper delves into the integration of microneedles with wearable technologies, highlighting their role in closed-loop systems that combine real-time monitoring with dynamic, precise therapeutic delivery. By addressing gaps in the literature regarding their integrated diagnostic and treatment capabilities, this review underscores the pivotal role of microneedles in personalizing medicine. It concludes with a visionary perspective on the future trajectory of microneedle technology, emphasizing its potential to revolutionize therapeutic strategies through enhanced efficacy, safety, and patient compliance.}, archive = {J_ADVS}, author = {Chan Wang and Yuan Yang and Jiaqi Zhang and Hanrui Zhang and Qian Wang and Shengmei Ma and Pengfei Zhao and Zhou Li and Yuxin Liu}, doi = {10.1002/advs.202412140}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2412140}, shortjournal = {Adv. Sci.}, title = {Microneedles at the forefront of next generation theranostics}, volume = {12}, year = {2025}, }
• (2025). Implantable self-powered systems for electrical stimulation medical devices. ADVS, 12(24), 2412044. (www)

  @article{ , abstract = {With the integration of bioelectronics and materials science, implantable self-powered systems for electrical stimulation medical devices have emerged as an innovative therapeutic approach, garnering significant attention in medical research. These devices achieve self-powering through integrated energy conversion modules, such as triboelectric nanogenerators (TENGs) and piezoelectric nanogenerators (PENGs), significantly enhancing the portability and long-term efficacy of therapeutic equipment. This review delves into the design strategies and clinical applications of implantable self-powered systems, encompassing the design and optimization of energy harvesting modules, the selection and fabrication of adaptable electrode materials, innovations in systematic design strategies, and the extensive utilization of implantable self-powered systems in biological therapies, including the treatment of neurological disorders, tissue regeneration engineering, drug delivery, and tumor therapy. Through a comprehensive analysis of the latest research progress, technical challenges, and future directions in these areas, this paper aims to provide valuable insights and inspiration for further research and clinical applications of implantable self-powered systems.}, archive = {J_ADVS}, author = {Xi Cui and Li Wu and Chao Zhang and Zhou Li}, doi = {10.1002/advs.202412044}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2412044}, shortjournal = {Adv. Sci.}, title = {Implantable self-powered systems for electrical stimulation medical devices}, volume = {12}, year = {2025}, }
• (2025). Progress and perspectives in 2D piezoelectric materials for piezotronics and piezo-phototronics. ADVS, 12(24), 2411422. (www)

  @article{ , abstract = {The emergence of two-dimensional (2D) materials has catalyzed significant advancements in the fields of piezotronics and piezo-phototronics, owing to their exceptional mechanical, electronic, and optical properties. This review provides a comprehensive examination of key 2D piezoelectric and piezo-phototronic materials, including transition metal dichalcogenides, hexagonal boron nitride (h-BN), and phosphorene, with an emphasis on their unique advantages and recent research progress. The underlying principles of piezotronics and piezo-phototronics in 2D materials is discussed, focusing on the fundamental mechanisms which enable these phenomena. Additionally, it is analyzed factors affecting piezoelectric and piezo-photoelectric properties, with a particular focus on the intrinsic piezoelectricity of 2D materials and the enhancement of out-of-plane polarization through various modulation techniques and materials engineering approaches. The potential applications of these materials are explored from piezoelectric nanogenerators to piezo-phototronic devices and healthcare. This review addresses future challenges and opportunities, highlighting the transformative impact of 2D materials on the development of next-generation electronic, optoelectronic, and biomedical devices.}, archive = {J_ADVS}, author = {Fengyi Pang and Pin Zhao and Hyeon Yeong Lee and Dae-Jin Kim and Xiangchun Meng and Yong Soo Cho and Sang-Woo Kim}, doi = {10.1002/advs.202411422}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2411422}, shortjournal = {Adv. Sci.}, title = {Progress and perspectives in 2D piezoelectric materials for piezotronics and piezo-phototronics}, volume = {12}, year = {2025}, }
• (2025). Advances in electrical materials for bone and cartilage regeneration: Developments, challenges, and perspectives. ADVS, 12(24), 2411209. (www)

  @article{ , abstract = {Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for bone regeneration, making electrical materials a promising therapy. This review provides a comprehensive overview of the role of bioelectric signals in bone and cartilage cells, alongside recent advancements in electrical biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, and zwitterionic hydrogels. It further investigates the impact of these electrical biomaterials on bone and cartilage regeneration, as well as the applications of both endogenous and exogenous electrical stimulation (ES) and the mechanisms underlying ES-induced cellular and molecular responses. Finally, the review underscores future directions for ES systems in tissue engineering, emphasizing the critical importance of integrating structural integrity, mechanical properties, and electrical signal delivery into intelligent implantable scaffolds.}, archive = {J_ADVS}, author = {Yubin Yao and Xi Cui and Shenglong Ding and Ketao Wang and Mingzhu Zhang}, doi = {10.1002/advs.202411209}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2411209}, shortjournal = {Adv. Sci.}, title = {Advances in electrical materials for bone and cartilage regeneration: Developments, challenges, and perspectives}, volume = {12}, year = {2025}, }
• (2025). Injectable pH responsive conductive hydrogel for intelligent delivery of metformin and exosomes to enhance cardiac repair after myocardial ischemia-reperfusion injury. ADVS, 12(24), 2410590. (www)

  @article{ , abstract = {Myocardial ischemia-reperfusion injury (MIRI) is a leading cause of complications and high mortality associated with acute myocardial infarction. Injectable hydrogel emerges as a promising biomaterial for myocardial repair due to their ability to mimic the mechanical and electrophysiological properties of heart tissue. In this study, an injectable conductive hydrogel is developed that responds to the weakly acidic microenvironment of ischemic injury, enabling the intelligent release of metformin and exosomes to enhance cardiac repair following MIRI. This multifunctional hydrogel demonstrates self-healing properties, shear-thinning injectability, electrical conductivity, and an elastic modulus comparable to natural myocardium, alongside excellent biocompatibility. At the cellular level, the hydrogel system exhibits significant antioxidant, anti-apoptotic, improvement of electrophysiological characteristics, mitochondrial protection and angiogenic effects, with transcriptome sequencing revealing the effective activation of the PI3K/AKT, VEGF, and AMPK signaling pathways. In vivo studies further confirm that the hydrogel treatment reduces infarct size, cardiac fibrosis and incidence of arrhythmia, while improving ventricular ejection fraction and facilitating the restoration of cardiac function after MIRI. In conclusion, an injectable pH-responsive conductive hydrogel is presented that enables the intelligent delivery of metformin and exosomes, offering a promising and novel therapeutic approach for enhancing cardiac repair and treating MIRI.}, archive = {J_ADVS}, author = {Nianlan Cheng and Qiao Luo and Yongqing Yang and Ni Shao and Tianqi Nie and Xiujiao Deng and Jifeng Chen and Siqi Zhang and Yanyu Huang and Kuan Hu and Liangping Luo and Zeyu Xiao}, doi = {10.1002/advs.202410590}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2410590}, shortjournal = {Adv. Sci.}, title = {Injectable pH responsive conductive hydrogel for intelligent delivery of metformin and exosomes to enhance cardiac repair after myocardial ischemia-reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Real-time wireless detection of heavy metal ions using a self-powered triboelectric nanosensor integrated with an autonomous thermoelectric generator-powered robotic system. ADVS, 12(24), 2410424. (www)

  @article{ , abstract = {The integration of the Internet of Things (IoT) with advanced sensing technologies is transforming environmental monitoring and public health protection. In this study, a fully self-powered and automated chemical sensing system is developed and integrated with a robotic hand for “touch and sense” detection of toxic heavy metal ions (Pb 2 ⁺, Cr⁶⁺, As 3 ⁺) in aquatic environments. The system combines a self-powered solid-liquid triboelectric nanosensor (SL-TENS) with a thermoelectric generator (TEG), which harnesses ambient heat to power the robotic hand, eliminating the need for external power sources. The robotic hand is controlled wirelessly via an exo-hand, minimizing the risk of exposure during remote monitoring. The sensing component uses copper oxide nanowires (CuO NWs) coated with ion-selective membranes (ISMs) to enhance triboelectric output and enable highly selective ion detection. The system demonstrates effective real-time, on-site detection in lake water and data transmitted wirelessly to the user. This innovative approach provides a highly safe and efficient method for detecting hazardous pollutants in difficult-to-access areas, offering significant potential for wireless and real-time environmental monitoring and hazard prevention, thus contributing to the safeguarding of human health. This study presents a novel advancement in the field of IoT-enabled environmental monitoring systems.}, archive = {J_ADVS}, author = {Yan-Tsz Huang and Arshad Khan and Anindita Ganguly and Kuldeep Kaswan and Sreerag Suresh and Yu-Ying Cheng and Kuan-Ming Lee and Jui-Han Yu and Zong-Hong Lin}, doi = {10.1002/advs.202410424}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2410424}, shortjournal = {Adv. Sci.}, title = {Real-time wireless detection of heavy metal ions using a self-powered triboelectric nanosensor integrated with an autonomous thermoelectric generator-powered robotic system}, volume = {12}, year = {2025}, }
• (2025). Advances in symbiotic bioabsorbable devices. ADVS, 12(24), 2410289. (www)

  @article{ , abstract = {Symbiotic bioabsorbable devices are ideal for temporary treatment. This eliminates the boundaries between the device and organism and develops a symbiotic relationship by degrading nutrients that directly enter the cells, tissues, and body to avoid the hazards of device retention. Symbiotic bioresorbable electronics show great promise for sensing, diagnostics, therapy, and rehabilitation, as underpinned by innovations in materials, devices, and systems. This review focuses on recent advances in bioabsorbable devices. Innovation is focused on the material, device, and system levels. Significant advances in biomedical applications are reviewed, including integrated diagnostics, tissue repair, cardiac pacing, and neurostimulation. In addition to the material, device, and system issues, the challenges and trends in symbiotic bioresorbable electronics are discussed.}, archive = {J_ADVS}, author = {Chang Zhu and Engui Wang and Zhou Li and Han Ouyang}, doi = {10.1002/advs.202410289}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2410289}, shortjournal = {Adv. Sci.}, title = {Advances in symbiotic bioabsorbable devices}, volume = {12}, year = {2025}, }
• (2025). Biodegradable and implantable triboelectric nanogenerator improved by β-lactoglobulin fibrils-assisted flexible PVA porous film. ADVS, 12(24), 2409914. (www)

  @article{ , abstract = {Triboelectric nanogenerators (TENGs) are highly promising as implantable, degradable energy sources and self-powered sensors. However, the degradable triboelectric materials are often limited in terms of contact electrification and mechanical properties. Here, a bio-macromolecule-assisted toughening strategy for PVA aerogel-based triboelectric materials is proposed. By introducing β-lactoglobulin fibrils (BF) into the PVA aerogel network, the material's mechanical properties while preserving its swelling resistance is significantly enhanced. Compared to pure PVA porous film, the BF-PVA porous film exhibits an eightfold increase in fracture strength (from 1.92 to 15.48 J) and a fourfold increase in flexibility (from 10.956 to 39.36 MPa). Additionally, the electrical output of BF-PVA in triboelectric performance tests increased nearly fivefold (from 45 to 203 V). Leveraging these enhanced properties, a biodegradable TENG (bi-TENG) for implantable muscle activity sensing is developed, achieving real-time monitoring of neuromuscular processes. This innovation holds significant potential for advancing implantable medical devices and promoting new applications in bio-integrated electronics.}, archive = {J_ADVS}, author = {Yichang Quan and Engui Wang and Han Ouyang and Lingling Xu and Lu Jiang and Lijing Teng and Jiaxuan Li and Lin Luo and Xujie Wu and Zhu Zeng and Zhou Li and Qiang Zheng}, doi = {10.1002/advs.202409914}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2409914}, shortjournal = {Adv. Sci.}, title = {Biodegradable and implantable triboelectric nanogenerator improved by β-lactoglobulin fibrils-assisted flexible PVA porous film}, volume = {12}, year = {2025}, }
• (2025). Electrical stimulation therapy – Dedicated to the perfect plastic repair. ADVS, 12(24), 2409884. (www)

  @article{ , abstract = {Tissue repair and reconstruction are a clinical difficulty. Bioelectricity has been identified as a critical factor in supporting tissue and cell viability during the repair process, presenting substantial potential for clinical application. This review delves into various sources of electrical stimulation and identifies appropriate electrode materials for clinical use. It also highlights the biological mechanisms of electrical stimulation at both the subcellular and cellular levels, elucidating how these interactions facilitate the repair and regeneration processes across different organs. Moreover, specific electrode materials and stimulation sources are outlined, detailing their impact on cellular activity. The future development trends are projected from two perspectives: the optimization of equipment performance and the fulfillment of clinical demands, focusing on the feasibility, safety, and cost-effectiveness of technologies.}, archive = {J_ADVS}, author = {Kexin Deng and Ruizeng Luo and Ying Chen and Xiaoqiang Liu and Yuanyin Xi and Muhammad Usman and Xupin Jiang and Zhou Li and Jiaping Zhang}, doi = {10.1002/advs.202409884}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2409884}, shortjournal = {Adv. Sci.}, title = {Electrical stimulation therapy – Dedicated to the perfect plastic repair}, volume = {12}, year = {2025}, }
• (2025). Nanotherapy for neural retinal regeneration. ADVS, 12(24), 2409854. (www)

  @article{ , abstract = {Retinal diseases can severely impair vision and even lead to blindness, posing significant threats to both physical and mental health. Physical retinal regenerative therapies are poised to revolutionize the treatment of various disorders associated with blindness. However, these therapies must overcome the challenges posed by the protective inner and outer blood‒retinal barriers. Nanotechnology applications in ophthalmology have shown great potential in addressing the issue of drug delivery to the eye. Moreover, nanotechnology-based therapeutics can have profound clinical impacts on retinopathy, particularly retinal regeneration, thereby improving patient outcomes. Continuous advancements in nanotechnology are being applied to regenerate lost or damaged eye tissues and to treat vision loss and blindness caused by various retinal degenerative diseases. These approaches can be categorized into three main strategies: i) nanoparticles for delivering drugs, genes, and other essential substances; ii) nanoscaffolds for providing biocompatible support; and iii) nanocomposites for enhancing the functionality of primary or stem cells. The aim of this comprehensive review is to present the current understanding of nanotechnology-based therapeutics for retinal regeneration, with a focus on the perspective functions of nanomaterials.}, archive = {J_ADVS}, author = {Chuyao Yu and Li Dong and Yujia Lv and Xuhan Shi and Ruiheng Zhang and Wenda Zhou and Haotian Wu and Heyan Li and Yitong Li and Zhou Li and Dan Luo and Wen-Bin Wei}, doi = {10.1002/advs.202409854}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2409854}, shortjournal = {Adv. Sci.}, title = {Nanotherapy for neural retinal regeneration}, volume = {12}, year = {2025}, }
• (2025). Electrical microneedles for wound treatment. ADVS, 12(24), 2409519. (www)

  @article{ , abstract = {Electrical stimulation has been hotpot research and provoked extensive interest in a broad application such as wound closure, tissue injury repair, and nerve engineering. In particular, immense efforts have been dedicated to developing electrical microneedles, which demonstrate unique features in terms of controllable drug release, real-time monitoring, and therapy, thus greatly accelerating the process of wound healing. Here, a review of state-of-art research concerning electrical microneedles applied for wound treatment is presented. After a comprehensive analysis of the mechanisms of electrical stimulation on wound healing, the derived three types of electrical microneedles are clarified and summarized. Further, their applications in wound healing are highlighted. Finally, current perspectives and directions for the development of future electrical microneedles in improving wound healing are addressed.}, archive = {J_ADVS}, author = {Yu Wang and Lijun Cai and Lu Fan and Li Wang and Feika Bian and Weijian Sun and Yuanjin Zhao}, doi = {10.1002/advs.202409519}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2409519}, shortjournal = {Adv. Sci.}, title = {Electrical microneedles for wound treatment}, volume = {12}, year = {2025}, }
• (2025). From lab to life: Self-powered sweat sensors and their future in personal health monitoring. ADVS, 12(24), 2409178. (www)

  @article{ , abstract = {The rapid development of wearable sweat sensors has demonstrated their potential for continuous, non-invasive disease diagnosis and health monitoring. Emerging energy harvesters capable of converting various environmental energy sources—biomechanical, thermal, biochemical, and solar—into electrical energy are revolutionizing power solutions for wearable devices. Based on self-powered technology, the integration of the energy harvesters with wearable sweat sensors can drive the device for biosensing, signal processing, and data transmission. As a result, self-powered sweat sensors are able to operate continuously without external power or charging, greatly facilitating the development of wearable electronics and personalized healthcare. This review focuses on the recent advances in self-powered sweat sensors for personalized healthcare, covering sweat sensors, energy harvesters, energy management, and applications. The review begins with the foundations of wearable sweat sensors, providing an overview of their detection methods, materials, and wearable devices. Then, the working mechanism, structure, and a characteristic of different types of energy harvesters are discussed. The features and challenges of different energy harvesters in energy supply and energy management of sweat sensors are emphasized. The review concludes with a look at the future prospects of self-powered sweat sensors, outlining the trajectory of the field and its potential to flourish.}, archive = {J_ADVS}, author = {Nan Gao and Guodong Xu and Gang Chang and Yuxiang Wu}, doi = {10.1002/advs.202409178}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2409178}, shortjournal = {Adv. Sci.}, title = {From lab to life: Self-powered sweat sensors and their future in personal health monitoring}, volume = {12}, year = {2025}, }
• (2025). Wearable systems of reconfigurable microneedle electrode array for subcutaneous multiplexed recording of myoelectric and electrochemical signals. ADVS, 12(24), 2409075. (www)

  @article{ , abstract = {The real-time monitoring of in vivo electrophysiological and biochemical signals provides critical insights into the activities of tissues and organs. As the activity and metabolic state of different sites in the muscle vary, multichannel detection is necessary to capture the functional state of the whole muscle, yet the access to the bio-information in subcutaneous space remained challenging. This work reports the development of a reconfigurable microneedle electrode array integrated system designed to achieve painless and minimally invasive monitoring of subcutaneous electromyogram (EMG), oxygen species, and pH through an array of thumbtack-shaped microneedle (TSMN) electrode. By assembling discrete TSMNs into an array, the system enables multi-parameter detection with single microneedle resolution. The PEDOT: PSS layer is electrochemically deposited on the TSMNs, enhancing their signal-sensing capabilities and electrochemical properties. Additionally, the design of the pogo pin interface ensures reliable signal transmission and stable device performance, while allowing flexible replacement of the TSMNs, which enhances system maintainability and longevity. Validation experiments conducted on in vivo animal models demonstrate the system's capability in real-time monitoring of muscle fatigue and indicators related to sciatic nerve injury. These results advance the development of wearable technologies for monitoring subcutaneous physiological and biochemical information for diagnosing neuromuscular disorders.}, archive = {J_ADVS}, author = {Zhengjie Liu and Chuanjie Yao and Xingyuan Xu and Xinshuo Huang and Shuang Huang and Shantao Zheng and Tao Zhang and Yan Li and Fanmao Liu and Yuxiang Wu and Jing Liu and Hui-jiuan Chen and Xi Xie}, doi = {10.1002/advs.202409075}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2409075}, shortjournal = {Adv. Sci.}, title = {Wearable systems of reconfigurable microneedle electrode array for subcutaneous multiplexed recording of myoelectric and electrochemical signals}, volume = {12}, year = {2025}, }
• (2025). Programmable NIR responsive nanocomposite enables noninvasive intratympanic delivery of dexamethasone to reverse cisplatin induced hearing loss. ADVS, 12(24), 2407067. (www)

  @article{ , abstract = {Local intratympanic drug delivery to the inner ear possesses significant otological clinical promise as cisplatin-induced hearing loss (CIHL) therapy, inducing significantly less side effects than systemic drug delivery. However, the multiple detoured barriers, round window membrane (RWM) and poorly controlled drug release hinder successful non-invasive drug delivery through intratympanic administration (IT). Here, a novel near-infrared (NIR) responsive nanocomposite functionalized with saponin, denoted gold nanorod@dexamethasone-mesoporous silica-saponin (AuNR@DEX-MS-saponin, NPs/DEX), is developed to enhance RWM permeation and to control the drug release spatiotemporally. First, the physiochemical properties and release profile of the synthesized nanocomposites are assessed, after which the biocompatibility of the nanocomposites and oto-protection against CIHL are shown in vitro and in vivo. The findings demonstrated that DEX is delivered to the inner ear with high efficiency through IT, due to the permeation enhancement effect of the nanocomposite. Moreover, the nanocomposite with low dose of DEX is highly effective in recovering CIHL, attenuating hair cell loss, and alleviating synaptic ribbon damage. These findings provide insight into NIR-responsive local delivery for inner ear illnesses.}, archive = {J_ADVS}, author = {Rawand A. Mustafa and Jiali Wang and Mengzhao Xun and Jessica M. Rosenholm and Wuqing Wang and Yilai Shu and Hongbo Zhang}, doi = {10.1002/advs.202407067}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2407067}, shortjournal = {Adv. Sci.}, title = {Programmable NIR responsive nanocomposite enables noninvasive intratympanic delivery of dexamethasone to reverse cisplatin induced hearing loss}, volume = {12}, year = {2025}, }
• (2025). Targeting decidual CD16+ immune cells with exosome-based glucocorticoid nanoparticles for miscarriage. ADVS, 12(24), 2406370. (www)

  @article{ , abstract = {Immune dysfunction in early pregnancy including overactivation of cytotoxic CD16 + NK cells and proinflammatory M1 macrophages at the maternal–fetal interface interferes with trophoblast invasion, spiral artery remodeling, and decidualization, potentially leading to miscarriage. Immunosuppressants like glucocorticoids (GCs) are used to regulate the immune microenvironment in clinical treatment, but the lack of safe and efficient tissue-specific drug delivery systems, especially immune cell-specific vectors, limits their widespread clinical application. Here, a previously uncharacterized delivery system is reported, termed GC-Exo-CD16Ab, in which GCs are loaded into purified exosomes derived from human umbilical cord mesenchymal stem cells, and subsequently decorated with antibody CD16Ab. GC-Exo-CD16Ab is biocompatible and has remarkable delivery efficiency toward CD16 + decidual natural killer (NK) cells and CD16 + macrophages in mice. This innovative approach effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and regulates the decidual microenvironment, thereby enhancing placental and fetal morphology, and ultimately mitigating miscarriage risk in the abortion-prone mice. The developed GC-Exo-CD16Ab provides a feasible platform for precise and tissue-specific therapeutic strategies for miscarriage and pregnancy-related diseases.}, archive = {J_ADVS}, author = {Linlin Wang and Zhinang Yin and Yanqiong Shen and Gang Feng and Fangfang Dai and Dongyong Yang and Zhimin Deng and Jing Yang and Ruizhi Chen and Leifeng Yang and Xian Chen and Qing Sun and Chunyu Huang and Yanxiang Cheng and Hongbing Deng and Lianghui Diao and Longfei Li and Tailang Yin}, doi = {10.1002/advs.202406370}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2406370}, shortjournal = {Adv. Sci.}, title = {Targeting decidual CD16+ immune cells with exosome-based glucocorticoid nanoparticles for miscarriage}, volume = {12}, year = {2025}, }
• (2025). Accelerated bone healing via electrical stimulation. ADVS, 12(24), 2404190. (www)

  @article{ , abstract = {Piezoelectric effect produces an electrical signal when stress is applied to the bone. When the integrity of the bone is destroyed, the biopotential within the defect site is reduced and several physiological responses are initiated to facilitate healing. During the healing of the bone defect, the bioelectric potential returns to normal levels. Treatment of fractures that exceed innate regenerative capacity or exhibit delayed healing requires surgical intervention for bone reconstruction. For bone defects that cannot heal on their own, exogenous electric fields are used to assist in treatment. This paper reviews the effects of exogenous electrical stimulation on bone healing, including osteogenesis, angiogenesis, reduction in inflammation and effects on the peripheral nervous system. This paper also reviews novel electrical stimulation methods, such as small power supplies and nanogenerators, that have emerged in recent years. Finally, the challenges and future trends of using electrical stimulation therapy for accelerating bone healing are discussed.}, archive = {J_ADVS}, author = {Jianfeng Sun and Wenqing Xie and Yuxiang Wu and Zhou Li and Yusheng Li}, doi = {10.1002/advs.202404190}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2404190}, shortjournal = {Adv. Sci.}, title = {Accelerated bone healing via electrical stimulation}, volume = {12}, year = {2025}, }
• (2025). Mechanochemistry: Fundamental principles and applications. ADVS, 12(24), 2403949. (www)

  @article{ , abstract = {Mechanochemistry is an emerging research field at the interface of physics, mechanics, materials science, and chemistry. Complementary to traditional activation methods in chemistry, such as heat, electricity, and light, mechanochemistry focuses on the activation of chemical reactions by directly or indirectly applying mechanical forces. It has evolved as a powerful tool for controlling chemical reactions in solid state systems, sensing and responding to stresses in polymer materials, regulating interfacial adhesions, and stimulating biological processes. By combining theoretical approaches, simulations and experimental techniques, researchers have gained intricate insights into the mechanisms underlying mechanochemistry. In this review, the physical chemistry principles underpinning mechanochemistry are elucidated and a comprehensive overview of recent significant achievements in the discovery of mechanically responsive chemical processes is provided, with a particular emphasis on their applications in materials science. Additionally, The perspectives and insights into potential future directions for this exciting research field are offered.}, archive = {J_ADVS}, author = {Liang Dong and Luofei Li and Huiyan Chen and Yi Cao and Hai Lei}, doi = {10.1002/advs.202403949}, journal = {Advanced Science}, month = {6}, number = {24}, pages = {2403949}, shortjournal = {Adv. Sci.}, title = {Mechanochemistry: Fundamental principles and applications}, volume = {12}, year = {2025}, }
• (2025). Accurate transcription factor activity inference to decipher cell identity from single-cell transcriptomic data with MetaTF. ADVS, 12(23), e10745. (www)

  @article{ , abstract = {Cellular heterogeneity within cancer tissues determines cancer progression and treatment response. Single-cell RNA sequencing (scRNA-seq) has provided a powerful approach for investigating the cellular heterogeneity of both cancer cells and stroma cells in the tumor microenvironment. However, the common practice to characterize cell identity based on the similarity of their gene expression profiles may not really indicate distinct cellular populations with unique roles. Generally, the cell identity and function are orchestrated by the expression of given specific genes tightly regulated by transcription factors (TFs). Therefore, deciphering TF activity is essential for gaining a better understanding of the uniqueness and functionality of each cell type. Herein, metaTF, a computational framework designed to infer TF activity in scRNA-seq data, is introduced and existing methods are outperformed for estimating TF activity. It presents the improved effectiveness in characterizing cell identity during mouse hematopoietic stem cell development. Furthermore, metaTF provides a superior characterization of the functional identity of breast cancer epithelial cells, and identifies a novel subset of neural-regulated T cells within the tumor immune microenvironment, which potentially activates BCL6 in response to neural-related signals. Overall, metaTF enables robust TF activity analysis from scRNA-seq data, significantly enhancing the characterization of cell identity and function.}, archive = {J_ADVS}, author = {Yongfei Hu and Yuanyuan Zhu and Guangjue Tang and Ming Shan and Puwen Tan and Ying Yi and Xiyuan Zhang and Man Liu and Xinyu Li and Le Wu and Jia Chen and Hailong Zheng and Yan Huang and Zhuan Li and Xiaobo Li and Dong Wang}, doi = {10.1002/advs.202410745}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {e10745}, shortjournal = {Adv. Sci.}, title = {Accurate transcription factor activity inference to decipher cell identity from single-cell transcriptomic data with MetaTF}, volume = {12}, year = {2025}, }
• (2025). Surface charge transfer enhanced cobalt-phthalocyanine crystals for efficient CO2-to-CO electroreduction with large current density exceeding 1000 mA cm−2 (Adv. sci. 23/2025). ADVS, 12(23), 2570184. (www)

  @article{ , archive = {J_ADVS}, author = {Tengyi Liu and Di Zhang and Yutaro Hirai and Koju Ito and Kosuke Ishibashi and Naoto Todoroki and Yasutaka Matsuo and Junya Yoshida and Shimpei Ono and Hao Li and Hiroshi Yabu}, doi = {10.1002/advs.202570184}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2570184}, shortjournal = {Adv. Sci.}, title = {Surface charge transfer enhanced cobalt-phthalocyanine crystals for efficient CO2-to-CO electroreduction with large current density exceeding 1000 mA cm−2 (Adv. sci. 23/2025)}, volume = {12}, year = {2025}, }
• (2025). Dual role of CRABP2 in colorectal cancer: Oncogenesis via nuclear RB1 and cytoplasmic AFG3L2/SLC25A39 axis, while limiting liver metastasis through cytoplasmic AFG3L2/PINK1/Parkin-mediated mitophagy (Adv. sci. 23/2025). ADVS, 12(23), 2570183. (www)

  @article{ , archive = {J_ADVS}, author = {Chuanxin Tian and Sheng Yang and Chuan Zhang and Renzhong Zhu and Chen Chen and Xiaowei Wang and Dongsheng Zhang and Qingyang Sun and Hengjie Xu and Hongxu Nie and Yue Zhang and Dongjian Ji and Junwei Tang and Kangpeng Jin and Yueming Sun}, doi = {10.1002/advs.202570183}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2570183}, shortjournal = {Adv. Sci.}, title = {Dual role of CRABP2 in colorectal cancer: Oncogenesis via nuclear RB1 and cytoplasmic AFG3L2/SLC25A39 axis, while limiting liver metastasis through cytoplasmic AFG3L2/PINK1/Parkin-mediated mitophagy (Adv. sci. 23/2025)}, volume = {12}, year = {2025}, }
• (2025). A bio-responsive hydrogel with spatially heterogeneous structure for treating infectious tissue injuries (Adv. sci. 23/2025). ADVS, 12(23), 2570182. (www)

  @article{ , archive = {J_ADVS}, author = {Zongtai Li and Tao Yang and Xiaolei Li and Panchao Yin and Bo Yang and Dongying Li and Yan Wang and Wei Teng and Qianqian Yu and Weichang Li}, doi = {10.1002/advs.202570182}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2570182}, shortjournal = {Adv. Sci.}, title = {A bio-responsive hydrogel with spatially heterogeneous structure for treating infectious tissue injuries (Adv. sci. 23/2025)}, volume = {12}, year = {2025}, }
• (2025). Simultaneous harvesting of bipolar plasmonic hot carriers for boosting photoconductivity in ag nanoprism-coupled lateral si p–n junction (Adv. sci. 23/2025). ADVS, 12(23), 2570181. (www)

  @article{ , archive = {J_ADVS}, author = {Yujin Park and Jihyang Park and Yeonghoon Jin and Yujin Roh and Hyunhwa Lee and Kyoungsik Yu and Moonsang Lee and Jeong Young Park}, doi = {10.1002/advs.202570181}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2570181}, shortjournal = {Adv. Sci.}, title = {Simultaneous harvesting of bipolar plasmonic hot carriers for boosting photoconductivity in ag nanoprism-coupled lateral si p–n junction (Adv. sci. 23/2025)}, volume = {12}, year = {2025}, }
• (2025). Chromosome-level genome assembly of the leafcutter bee megachile rotundata reveals its ecological adaptation and pollination biology (Adv. sci. 23/2025). ADVS, 12(23), 2570179. (www)

  @article{ , archive = {J_ADVS}, author = {Rangjun Shi and Pan Duan and Mengmeng Zhu and Rong Zhang and Zihua Zhao and Xin Nie and Hanhou He and Li Hou and Xianhui Wang}, doi = {10.1002/advs.202570179}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2570179}, shortjournal = {Adv. Sci.}, title = {Chromosome-level genome assembly of the leafcutter bee megachile rotundata reveals its ecological adaptation and pollination biology (Adv. sci. 23/2025)}, volume = {12}, year = {2025}, }
• (2025). Targeted delivery of α-ketoglutarate to macrophages in bone: A novel therapeutic strategy for improving fracture healing in type 2 diabetes (Adv. sci. 23/2025). ADVS, 12(23), 2570178. (www)

  @article{ , archive = {J_ADVS}, author = {Jing Wang and Jiahao Cao and Siqi Zhang and Hongli Chen and Xuebing Yu and Xinli Wang and Tianji Wang and Wei Cao and Wengang Dong and Xinsen Lin and Jia Li and Wei Lei and Yafei Feng}, doi = {10.1002/advs.202570178}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2570178}, shortjournal = {Adv. Sci.}, title = {Targeted delivery of α-ketoglutarate to macrophages in bone: A novel therapeutic strategy for improving fracture healing in type 2 diabetes (Adv. sci. 23/2025)}, volume = {12}, year = {2025}, }
• (2025). Hydrogel-transformable probiotic powder for targeted eradication of helicobacter pylori with enhanced gastric mucosal repair and microbiota preservation (Adv. sci. 23/2025). ADVS, 12(23), 2570177. (www)

  @article{ , archive = {J_ADVS}, author = {Yongkang Lai and Hanchun Shen and Shige Wang and Yongliang Ouyang and Xinyuan Zhang and Bin Hu and Xiaoyi Zhang and Guisheng Li and Lizhi Xu and Jiulong Zhao}, doi = {10.1002/advs.202570177}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2570177}, shortjournal = {Adv. Sci.}, title = {Hydrogel-transformable probiotic powder for targeted eradication of helicobacter pylori with enhanced gastric mucosal repair and microbiota preservation (Adv. sci. 23/2025)}, volume = {12}, year = {2025}, }
• (2025). Coordinated role of autophagy and ERAD in maintaining neuroendocrine function by preventing prohormone aggregation (Adv. sci. 23/2025). ADVS, 12(23), 2570176. (www)

  @article{ , archive = {J_ADVS}, author = {Xuya Pan and Xing He and Su Wu and Na Xiong and Xinyu Hou and Heting Wang and Diane Somlo and Martin Spiess and Haiyang Wang and Jifeng Yang and Chunliang Li and Shasha Li and Wenbin Ma and Yanming Chen and Jun Cui and Ling Qi and Guojun Shi}, doi = {10.1002/advs.202570176}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2570176}, shortjournal = {Adv. Sci.}, title = {Coordinated role of autophagy and ERAD in maintaining neuroendocrine function by preventing prohormone aggregation (Adv. sci. 23/2025)}, volume = {12}, year = {2025}, }
• (2025). Inorganic biomaterials shape the transcriptome profile to induce endochondral differentiation. ADVS, 12(23), 2505203. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202505203}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2505203}, shortjournal = {Adv. Sci.}, title = {Inorganic biomaterials shape the transcriptome profile to induce endochondral differentiation}, volume = {12}, year = {2025}, }
• (2025). Electric field-driven conformational changes in molecular memristor and synaptic behavior. ADVS, 12(23), 2505016. (www)

  @article{ , abstract = {This paper demonstrates the use of molecular artificial synapses in neuromorphic computing systems designed for low energy consumption. A molecular junction, based on self-assembled monolayers (SAMs) of alkanethiolates terminated with 2 , 2 ′-bipyridine complexed with cobalt chloride, exhibits synaptic behaviors with an energy consumption of 8.0 pJ µm −2 . Conductance can be modulated simply by applying pulses in the incoherent charge transport (CT) regime. Charge injection in this regime allows molecules to overcome the low energy barrier for C─C bond rotations, resulting in conformational changes in the SAMs. The reversible potentiation/depression process of conductance achieves 90% accuracy in recognizing patterns from the Modified National Institute of Standards and Technology (MNIST) handwritten digit database. The molecular junction further exhibits both rectifying and conductance hysteresis behaviors, showing potential for use in selector-free synaptic arrays that efficiently suppress sneak currents.}, archive = {J_ADVS}, author = {Chanjin Lim and Taegil Kim and YoungJu Park and Daeho Kim and ChaeHo Shin and Suji Ha and Jin-Liang Lin and Yuan Li and Junwoo Park}, doi = {10.1002/advs.202505016}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2505016}, shortjournal = {Adv. Sci.}, title = {Electric field-driven conformational changes in molecular memristor and synaptic behavior}, volume = {12}, year = {2025}, }
• (2025). Overcoming extreme ammonia inhibition on methanogenesis by artificially constructing a synergistically community with acidogenic bacteria and hydrogenotrophic archaea. ADVS, 12(23), 2502743. (www)

  @article{ , abstract = {High total ammonia nitrogen (TAN) inhibits anaerobic digestion (AD) and cannot be completely eliminated by merely enhancing a stage of AD. This study incorporates TAN-tolerant inoculum into substrates hydrolyzed by Rhizopus mixed agents to simultaneously enhance hydrolysis-acidogenesis-methanogenesis. The results show a 16.46-fold increase in CH4 production under TAN-inhibited (6870.97 mg L−1) conditions, even exceeding the AD without TAN by 21.10%. Model substrates sodium acetate and mixed H2 confirm hydrogenotrophic methanogenesis is the main pathway, with reduced TAN inhibition. Furthermore, a synergistic metabolic microbial community dominated by hydrolytic bacteria JAAYGG01 sp. and DTU014 sp., acidogenic bacteria DTU015 sp., DTU013 sp., and JAAYLO01 sp., and methanogens Methanosarcina mazei and an unclassified species in the Methanoculleus is reconstructed to resist TAN inhibition. Metagenomic combined with metatranscriptomic sequencing identifies that this microbial community carries xynD and bglB to regulate substrate hydrolysis, leading to acetate production through glycolysis, butyrate, and pyruvate metabolism with high acetate kinase activity, thereby CH4 produced primarily via hydrogenotrophic methanogenesis with high coenzyme F420 activity, facilitated by efficient mass transfer processes and quorum sensing regulation. This cleaner strategy obtains higher economic benefit (US$149.02) than conventional AD and can increase 154.64-fold energy production of a 24 000 m3 biogas plant, guided by machine learning.}, archive = {J_ADVS}, author = {Heng Wu and Huaiwen Zhang and Taili Dong and Zhenyu Li and Xiaohui Guo and Heyu Chen and Yiqing Yao}, doi = {10.1002/advs.202502743}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2502743}, shortjournal = {Adv. Sci.}, title = {Overcoming extreme ammonia inhibition on methanogenesis by artificially constructing a synergistically community with acidogenic bacteria and hydrogenotrophic archaea}, volume = {12}, year = {2025}, }
• (2025). Surface charge transfer enhanced cobalt-phthalocyanine crystals for efficient CO2-to-CO electroreduction with large current density exceeding 1000 mA cm−2. ADVS, 12(23), 2501459. (www)

  @article{ , abstract = {Phthalocyanines (Pcs) have garnered significant attention as promising catalysts for electrochemical CO 2 reduction (ECR); however, traditional methods for preparing carbon-supported Pcs are often complex and time-consuming, limiting their industrial applicability. Herein, a rapid spray-growth method is introduced that directly deposits CoPc crystals onto carbon paper (CP) in just 15 min. The resulting CoPc/CP electrode maintains > 90% CO selectivity across a broad ECR window (−0.57 to −1.32 V vs RHE), achieves a record-breaking CO current density of −1034 mA cm −2 , an ultrahigh mass activity of 5180 A g −1 , and demonstrates excellent long-term stability (145 h @ −150 mA cm −2 ), surpassing all reported Pc-based catalysts. Comprehensive characterization attributes this high performance to its carbon-supported-crystalline structure and surface charge transfer (SCT). Density functional theory (DFT) calculations further reveal that even minimal SCT effectively optimizes the adsorption energies of key intermediates ( * CO and * COOH), thereby significantly enhancing intrinsic activity. Moreover, this spray-grown electrode offers unique structural advantages, such as strong substrate adhesion and internal layers that replenish active sites—features absent in traditional carbon-supported electrodes. It is believed that this facile spray-growth method holds broad potential and enables the application of additional Pc-based materials for industrial-scale ECR.}, archive = {J_ADVS}, author = {Tengyi Liu and Di Zhang and Yutaro Hirai and Koju Ito and Kosuke Ishibashi and Naoto Todoroki and Yasutaka Matsuo and Junya Yoshida and Shimpei Ono and Hao Li and Hiroshi Yabu}, doi = {10.1002/advs.202501459}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2501459}, shortjournal = {Adv. Sci.}, title = {Surface charge transfer enhanced cobalt-phthalocyanine crystals for efficient CO2-to-CO electroreduction with large current density exceeding 1000 mA cm−2}, volume = {12}, year = {2025}, }
• (2025). Low-frequency noise spectroscopy for navigating geometrically varying strain effects in HfO2 ferroelectric FETs. ADVS, 12(23), 2501367. (www)

  @article{ , abstract = {Strain engineering has been widely employed to control and enhance the ferroelectric properties of hafnium oxide (HfO₂)-based thin films. While previous studies focused on the influence of the strain in simple metal-ferroelectric-metal structures, the integration of strain-induced ferroelectricity into field-effect transistors (FETs) requires consideration of geometrical factors, such as the interfaces between the channel and source/drain contacts, as well as device dimension. Here, we demonstrate strain effects in HfO₂-based ferroelectric FETs (FeFETs) with poly-Si channels via low-frequency noise (LFN) spectroscopy. LFN analysis reveals that the strain during the post-metal annealing introduces damage to channel interface with its severity depending on the device geometry. This strain-dependent behavior results in a unique noise characteristic, which we refer to as the reverse scaling effect , where noise increases with longer channel lengths—contrary to the conventional trend in typical FETs, where noise decreases with increasing channel length. Furthermore, we observe that while increased strain enhances ferroelectricity, it also degrades the electrical performance of poly-Si FeFETs, primarily through damage to the channel interfaces. These findings underscore the critical role of strain engineering in FeFETs and provide important guidelines for balancing strain effects to achieve optimal ferroelectricity and reliability in future device designs.}, archive = {J_ADVS}, author = {Ryun-Han Koo and Wonjun Shin and Sangwoo Kim and Jangsaeng Kim and Been Kwak and Jiseong Im and Hyunwoo Kim and Deok-Hwang Kwon and Suraj S. Cheema and Jong-Ho Lee and Daewoong Kwon}, doi = {10.1002/advs.202501367}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2501367}, shortjournal = {Adv. Sci.}, title = {Low-frequency noise spectroscopy for navigating geometrically varying strain effects in HfO2 ferroelectric FETs}, volume = {12}, year = {2025}, }
• (2025). Multispectral photonic structural colors via enhanced interfacial interference of ultrathin cellulose Nanofiber/MXene films. ADVS, 12(23), 2500953. (www)

  @article{ , abstract = {The study reports novel photonic properties of Ti 3 C 2 T x MXene flakes horizontally self-assembled within cellulose nanofiber (CNF) matrix exhibiting unique bright multispectral colors combined with overall high transparency in the transmission regime. The intense reflection colors are reflected by individual flakes acting as effective micromirrors with shifts based on their subsurface positioning within the dielectric layers. Unique color appearances are controlled by an interplay of multiple bandgaps formed by constructive and destructive interferences at flake-matrix interfaces. These colors manifest at the microscale under bright field optical microscopy, while the total physical film retains high transparency up to 85% and a typical greenish hue characteristic of the MXene content below 1% volume fraction. The diverse spectral appearance of 4 µm ultra-thin films is ultimately controlled by the positioning of the horizontal flakes within the nanofiber matrix at diverse distances from the top surface. This work expands the understanding of thin films with assembled 2D materials within polymer matrix and their fundamental interactions creating new structural coloration functionalities with the potential for multispectral photonic applications such as camouflaging, photothermal treatment, and optical communication for flexible thin bio-derived films.}, archive = {J_ADVS}, author = {Valeriia Poliukhova and Botyo Dimitrov and Justin Brackenridge and Laura Mae Killingsworth and Iryna Roslyk and James Fitzpatrick and Yury Gogotsi and Vladimir V. Tsukruk}, doi = {10.1002/advs.202500953}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500953}, shortjournal = {Adv. Sci.}, title = {Multispectral photonic structural colors via enhanced interfacial interference of ultrathin cellulose Nanofiber/MXene films}, volume = {12}, year = {2025}, }
• (2025). Self-oscillation in active wires with asymmetric willis-type viscosity. ADVS, 12(23), 2500737. (www)

  @article{ , abstract = {Wires designed to carry loads through uniaxial tensile forces are particularly useful in creating large-span, yet lightweight, structures of diverse shapes and functions. Incorporating self-oscillation capabilities within the wires could be a promising approach to enhance the autonomous dynamic functions of these structures. However, self-oscillation, which usually appears in biological organisms and active materials, requires complex feedback interactions between activity and elasticity, hindering their application in self-oscillating wires. Here, a simple self-oscillation strategy is suggested by extending Willis elasticity to Willis-type viscosity through an irreversible coupling between strain rate and body force. A class of active wires equipped with electro-magneto-mechanically coupled feedforward loops is designed to realize the irreversible coupling. Numerical experiments show that the active wire hosts biased limit-cycle self-oscillation, where oscillation amplitudes are amplified linearly along one direction. Using continuum models, the linear amplification is interpreted as the force equilibrium caused by asymmetric Willis viscosity. In the design, the oscillation mode shape can be tailored independently of frequency, and the active wire supports the standing propagating mode transition. The design and continuum model suggested can benefit the development of autonomous materials for large-span structures.}, archive = {J_ADVS}, author = {Xingbo Pu and Xiaoyu Hou and Antonio Palermo and Yangyang Chen}, doi = {10.1002/advs.202500737}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500737}, shortjournal = {Adv. Sci.}, title = {Self-oscillation in active wires with asymmetric willis-type viscosity}, volume = {12}, year = {2025}, }
• (2025). Injectable and sprayable thermoresponsive hydrogel with fouling-resistance as an effective barrier to prevent postoperative cardiac adhesions. ADVS, 12(23), 2500731. (www)

  @article{ , abstract = {Postoperative adhesions are inevitable consequences of surgery, resulting in various complications. The risk increases, particularly in cardiac surgery, where reoperations or staged operations are in high demand. The presence of cardiac adhesions severely complicates resternotomy procedures, which may increase the risk of re-traumatizing, bleeding, operation time extension, and even mortality. Here, a biodegradable thermo-sensitive fouling-resistant hydrogel based on poly(D,L-lactide)/poly(ethylene glycol) (PLEL) micelles is developed, exhibiting high compatibility with both thoracotomies and minimally invasive interventions. By combining the advantages of liquid and film barriers, this hydrogel can completely cover irregular wounds after injecting or spraying and fully avoid direct contact with injuries between adjacent wound surfaces during the critical course of adhesion formation. In both the primary cardiac adhesion model and the severe repeated-injury cardiac adhesion model, the PLEL hydrogel is more effective than commercially available products (including Interceed film and sodium hyaluronate hydrogel) in significantly reducing the incidence and severity of adhesions, without causing any cardiac dysfunction or organ damage. The powerful anti-adhesion effect of PLEL hydrogel is closely related to its ability to inhibit the inflammatory response and balance the fibrinolysis system. This injectable and sprayable antifouling thermosensitive hydrogel represents a promising clinical solution for the prevention of postoperative and recurrent cardiac adhesion.}, archive = {J_ADVS}, author = {Kun Shi and Tao Li and Xulin Hu and Wen Chen and Yan Yu and Zhongwu Bei and Liping Yuan and Qi Tong and Jiafeng Liu and Qiang Fan and Yongjun Qian and Zhiyong Qian}, doi = {10.1002/advs.202500731}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500731}, shortjournal = {Adv. Sci.}, title = {Injectable and sprayable thermoresponsive hydrogel with fouling-resistance as an effective barrier to prevent postoperative cardiac adhesions}, volume = {12}, year = {2025}, }
• (2025). Wonders of harbor and grey seal whiskers: Morphology, natural frequencies, and 3D modeling. ADVS, 12(23), 2500724. (www)

  @article{ , abstract = {Seals can track fish using highly sensitive whiskers; however, the extent to which their morphologically diverse whiskers respond to hydrodynamic signals across frequencies remains unexplored. To address this, the lengths, thicknesses, curvatures, and natural frequencies of whisker arrays in grey seals ( Halichoerus grypus ) and harbor seals ( Phoca vitulina ) are measured. These values are mapped to their corresponding locations on the seal muzzle, and spatial trends (rostral-caudal and ventral-dorsal) are analyzed. These findings show that over 50% of whiskers exhibit underwater natural frequencies exceeding 80 Hz, which overlap with hydrodynamic fish trail frequencies (>100 Hz), demonstrating the adaptation of seal whiskers to hydrodynamic signals. Additionally, an open-access database of 141 full-length 3D whisker models is established. A streamlined method based on Euler spirals is proposed to fit and map seal whiskers simultaneously. This method evaluates the curvature of the full-length seal whisker and calculates morphological parameters (e.g., whisker axis and cross-sectional orientation angles) that are required for 3D whisker construction. The database of 3D seal whiskers offers a valuable resource for researchers in computational fluid dynamics, experimental biology, and sensor technology, supporting multidisciplinary studies of seal whiskers.}, archive = {J_ADVS}, author = {Xingwen Zheng and Amar M. Kamat and Ming Cao and Michael S. Triantafyllou and Ajay Giri Prakash Kottapalli}, doi = {10.1002/advs.202500724}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500724}, shortjournal = {Adv. Sci.}, title = {Wonders of harbor and grey seal whiskers: Morphology, natural frequencies, and 3D modeling}, volume = {12}, year = {2025}, }
• (2025). Ultrasound-triggered nanocomposite “Lever” hydrogels with a full repair system accelerates diabetic foot ulcer repair. ADVS, 12(23), 2500720. (www)

  @article{ , abstract = {Diabetic foot ulcers (DFUs) are a complex mixture of neuropathy, peripheral arterial disease, and infection, where excessive reactive oxygen species (ROS) exacerbates inflammation and impairs healing. Therefore, there is an urgent need to design a hydrogel dressing with a ‘lever’ function to balance ROS levels in the wound to achieve both antimicrobial and anti-inflammatory effects on DFUs. In this study, we synthesised ROS-responsive diselenide liposomes loaded with a pro-skin healing factor (ergothioneine (ET)), thrombin, and a sonosensitizer (HMME) and constructed nanocomposite ‘lever’ hydrogels modulated by ultrasound (US). During early infection, sonodynamic therapy (SDT) under US generates bactericidal ROS, cleaving diselenide bonds to release ET and thrombin. Upon US cessation, thrombin/fibrinogen forms an in situ gel, while ET scavenges residual ROS and promotes M2 macrophage polarization in later stages. In addition, the potential immunomodulatory mechanisms of the nanocomposite ‘lever’ hydrogels were investigated via RNA sequencing. In conclusion, the novel nanocomposite ‘lever’ hydrogels effectively achieved a balance between ROS production and annihilation during different stages of wound repair while providing antibacterial and anti-inflammatory properties to promote neovascularisation and improve diabetic peripheral neuropathy. In conclusion, by precisely controlling ROS levels across wound-healing phases, this strategy offers a promising solution for refractory DFUs.}, archive = {J_ADVS}, author = {Yuting Shen and Shaoyue Li and Xiaodong Hou and Jifeng Yu and Yuli Zhu and Chongke Zhao and Zhiyuan Niu and Xin Guan and Bing Xiong and Sirui Wang and Yifei Yang and Xiao Li and Liping Sun and Shengbo Wu and Bin Huang and Huixiong Xu and Haohao Yin}, doi = {10.1002/advs.202500720}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500720}, shortjournal = {Adv. Sci.}, title = {Ultrasound-triggered nanocomposite “Lever” hydrogels with a full repair system accelerates diabetic foot ulcer repair}, volume = {12}, year = {2025}, }
• (2025). An intelligent and conductive hydrogel with multiresponsive and ROS scavenging properties for infection prevention and anti-inflammatory treatment assisted by electrical stimulation for diabetic wound. ADVS, 12(23), 2500696. (www)

  @article{ , abstract = {Diabetic wounds experience a hyperglycemic, hypoxic environment, combined with ongoing oxidative stress and inflammatory imbalances, significantly disrupts normal healing process. Advanced hydrogels have been considered one of the most exciting medical biomaterials for the potential in wounds healing. Herein, a novel conductive hydrogel (HEPP), designed to release nanozyme (PTPPG) in response to its microenvironment, was created to facilitate glucose (Glu) catabolism. Furthermore, the HEPP integrates photodynamic therapy (PDT), photothermal therapy (PTT), and self-cascading reactive oxygen species (ROS) to prevent bacterial infections while ensuring a continuous supply of oxygen (O 2 ) to the wound. The HEPP not only adeptly controls high ROS levels, but also enhances the regulation of inflammation in the wound area via electrical stimulation (ES), thereby promoting healing that is supported by the immune response. Studies conducted in vitro, along with transcriptomic analyses, indicate that ES primarily mitigates inflammation by regulating Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). The effects of HEPP combined with ES are primarily connected to their impact on TNF signaling pathways. By reducing the formation of ROS and employing ES to effectively lessen inflammation, this approach offers an innovative method to manage complicated diabetic wounds, ulcers, and a range of inflammatory conditions linked to infections.}, archive = {J_ADVS}, author = {Tao Zhang and Zongwu Meng and Haoyu Yu and Ping Ding and Tianhan Kai}, doi = {10.1002/advs.202500696}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500696}, shortjournal = {Adv. Sci.}, title = {An intelligent and conductive hydrogel with multiresponsive and ROS scavenging properties for infection prevention and anti-inflammatory treatment assisted by electrical stimulation for diabetic wound}, volume = {12}, year = {2025}, }
• (2025). Bimetallic Ca/Zn nanoagonist remould the immunosuppressive hepatocellular carcinoma microenvironment following incomplete microwave ablation via pyroptosis and the STING signaling pathway. ADVS, 12(23), 2500670. (www)

  @article{ , abstract = {During the treatment of solid tumors, local therapeutic approaches carry the risk of incomplete radical cure, which may lead to rapid tumor growth. Incomplete microwave ablation (iMWA) can induce tumors to exhibit highly invasive and uncontrollable growth, which is related to the immunosuppressive microenvironment. A multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) with a biomimetic liposome-modified surface to tumor tissues after iMWA is developed. In response to the acidic tumor microenvironment, the released traditional Chinese medicine preparation Pien Tze Huang (PZH) reduced protein expressions of the JAK2-STAT3 signaling pathway, thereby slowing down the proliferation and growth of hepatocellular carcinoma (HCC). Furthermore, the bimetallic ions Ca 2 ⁺ and Zn 2 ⁺ can cascade to enhance the killing effect of oxidative stress, generating substantial amounts of reactive oxygen species. This process induces pyroptosis and releases significant quantities of damage associated molecular patterns, thereby triggering immune activation mechanisms related to the STING pathway that reshape the immunosuppressive HCC microenvironment resulting from iMWA. This strategy markedly differs from previous chemoimmunotherapies, which not only effectively addressed the problem of conventional drugs showing heterogeneous distribution in tumor regions, but also verified the critical role played by PZH/Zn@CaNA in inhibiting iMWA-induced rapid tumor growth, regulating oxidative stress and remodeling the immunosuppressive tumor microenvironment.}, archive = {J_ADVS}, author = {Yuan Ling and Xiayi Liang and Kangning Yan and Guichun Zeng and Xiaoqi Zhu and Jinghang Jiang and Shaolong Lu and Xiaobo Wang and Yuying Zhou and Zhaoshen Li and Wei Mai and Duo Wang and Jie Chen}, doi = {10.1002/advs.202500670}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500670}, shortjournal = {Adv. Sci.}, title = {Bimetallic Ca/Zn nanoagonist remould the immunosuppressive hepatocellular carcinoma microenvironment following incomplete microwave ablation via pyroptosis and the STING signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Efficient generation of megakaryocyte progenitors and platelets from HSPCs via JAK2/STAT3 signaling. ADVS, 12(23), 2500612. (www)

  @article{ , abstract = {The supply of platelets for clinical transfusion is often insufficient to meet growing demand. Platelet regeneration from stem cells offers a potential solution to reduce reliance on donor-based transfusions. However, the current differentiation efficiency is suboptimal. A novel approach is presented that significantly enhances platelet yield from hematopoietic stem and progenitor cells (HSPCs) by increasing the production of megakaryocyte progenitors (MkPs) and mature megakaryocytes (MKs). This method employs the overexpression of HES7 combined with the HDAC inhibitor and GABA agonist (collectively termed the VGM cocktail). The VGM cocktail induces MkP production with an efficiency of up to 90%, validated across HSPCs from various donors. These MkPs exhibit extended proliferative capacity, remaining viable for up to 51 days in prolonged culture, and show enhanced maturation into MKs. This differentiation system effectively replicates in vivo thrombocytopoiesis, as evidenced by polyploidization, long protrusions, and proplatelet formation. Transfusion of VGM-induced MkPs into thrombocytopenic mice results in the release of platelets into circulation. Mechanistic investigation identifies the JAK2/STAT3 signaling pathway as critical in promoting megakaryopoiesis within this system. Therefore, this study demonstrates that the VGM cocktail facilitates enhanced platelet production by promoting MkP generation, offering a promising strategy for in vitro platelet regeneration for clinical applications.}, archive = {J_ADVS}, author = {Huicong Liu and Lingna Wang and Jiaqing Liu and Haitao Yuan and Kaiqing Zhang and Yun Qiu and Fangfang Zhu}, doi = {10.1002/advs.202500612}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500612}, shortjournal = {Adv. Sci.}, title = {Efficient generation of megakaryocyte progenitors and platelets from HSPCs via JAK2/STAT3 signaling}, volume = {12}, year = {2025}, }
• (2025). Large built-in fields and tunable ferroelectricity in composition-graded ScAlN thin films deposited by reactive sputtering. ADVS, 12(23), 2500611. (www)

  @article{ , abstract = {The control of the coercive field and growth of abnormally oriented grains (AOGs) in wurtzite ferroelectric Sc x Al 1-x N thin films is crucial for piezoelectric and ferroelectric applications. However, elevated Sc concentrations generally result in significant AOG growth and high leakage current, degrading piezoelectric and ferroelectric properties. Here, compositionally graded Sc x Al 1-x N layered structures grown by sputtering are explored to effectively limit the AOG growth, compared to the 8–10% typically observed in conventional films, without requiring process optimization. Notably, a large built-in electric field of ≈0.45 MV cm −1 , nearly 2.5 times larger than in graded PbZr x Ti 1-x O 3 (PZT) and BaSr x Ti 1-x O 3 (BST) systems, is achieved. This built-in field induces unique features, including horizontal shifts in polarization-electric field hysteresis loops, bi-stable states in capacitance-voltage characteristics, and highly asymmetric electrostrain behavior. Unlike other graded systems, this large built-in field in the graded Sc x Al 1-x N films arises primarily from polarization and chemical gradients. These findings offer a simplified, scalable and CMOS-compatible strategy to overcome the AOG challenges and tune ferroelectric properties of Sc x Al 1-x N thin films, providing the path for potential applications in advanced photonic and MEMS devices with improved performance and low-power consumption.}, archive = {J_ADVS}, author = {Tai Nguyen and Anirban Ghosh and Thang Duy Dao and Maja Koblar and Goran Drazic and Nikolai Andrianov and Iurii Nesterenko and Sanjay Nayak and Joaquin Miranda and Andreja Bencan Golob and Mohssen Moridi and Marco Deluca}, doi = {10.1002/advs.202500611}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500611}, shortjournal = {Adv. Sci.}, title = {Large built-in fields and tunable ferroelectricity in composition-graded ScAlN thin films deposited by reactive sputtering}, volume = {12}, year = {2025}, }
• (2025). Wogonin attenuates atherosclerosis via KLF11-mediated suppression of PPARα-YAP1-driven glycolysis and enhancement of ABCA1/G1-mediated cholesterol efflux. ADVS, 12(23), 2500610. (www)

  @article{ , abstract = {Atherosclerosis, a chronic inflammatory disorder and leading cause of cardiovascular disease, is characterized by macrophage-derived inflammation and foam cell formation. Emerging evidence suggests that metabolic reprogramming of macrophages represents a promising therapeutic approach for atherosclerosis management. In this study, the therapeutic potential of wogonin, a bioactive flavonoid isolated from Scutellaria baicalensis, in modulating macrophage metabolism and attenuating atherogenesis is investigated. Wogonin reduces lesion size and plaque vulnerability, accompanied by a reduction in foam cell formation and inflammation. Mechanistically, wogonin reprogrammes macrophage metabolism from glycolysis to fatty acid oxidation (FAO) by activating the PPARα-CPT1α pathway and acts as a mitochondrial protector by activating PPARα. Wogonin also promotes the KLF11 expression and KLF11 knockout exacerbated atherosclerosis and abolishes the inhibitory effect of wogonin on glycolysis and atherosclerosis. KLF11 forms a transcriptional complex with PPARα and YAP1, serving both as a brake on PPARα-YAP1-mediated glycolysis and a transcriptional activator of ABCA1/G1. Collectively, wogonin reprograms macrophage metabolism from glycolysis to FAO through activation of the PPARα-KLF11-YAP1 pathway, thereby reducing inflammation and foam cell formation, ultimately attenuating atherogenesis.}, archive = {J_ADVS}, author = {Chuanrui Ma and Yunqing Hua and Shu Yang and Yun Zhao and Wei Zhang and Yaodong Miao and Jing Zhang and Boxuan Feng and Guobin Zheng and Lan Li and Zhihao Liu and Han Zhang and Mingjun Zhu and Xiumei Gao and Guanwei Fan}, doi = {10.1002/advs.202500610}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500610}, shortjournal = {Adv. Sci.}, title = {Wogonin attenuates atherosclerosis via KLF11-mediated suppression of PPARα-YAP1-driven glycolysis and enhancement of ABCA1/G1-mediated cholesterol efflux}, volume = {12}, year = {2025}, }
• (2025). 3D-printed titanium trabecular scaffolds with sustained release of hypoxia-induced exosomes for dual-mimetic bone regeneration. ADVS, 12(23), 2500599. (www)

  @article{ , abstract = {Current Ti-6Al-4V bone implants lack trabecular structure and pro‑angiogenic cues, both essential for regeneration. Herein, a dual biomimetic strategy is devised that integrates a 3D-printed biomimetic trabecular porous Ti-6Al-4V scaffold (BTPS) with exosome-loaded PEGDA/GelMA hydrogel microspheres (PGHExo) designed for sustained release. BTPS is designed using Voronoi algorithms and imaging data, and replicates the geometry and mechanical properties of natural bone. Hypoxia-induced human umbilical vein endothelial cell (HUVEC) derived exosomes (HExo) are encapsulated in PGHExo microspheres via microfluidic technology, enabling controlled release of HExo, and anchored onto BTPS using polydopamine (pDA) modification (BTPS&pDA@PGHExo). BTPS exhibited an elastic modulus of ≈3.2 GPa and a permeability of 11.52 × 10 −8 mm 2 , mimicking natural bone. In vitro assays demonstrated that BTPS&pDA@PGHExo significantly enhanced osteogenesis and angiogenesis. mRNA-Seq analysis suggested that BTPS&pDA@PGHExo regulates osteogenic and angiogenic gene expression through the activation of pathways including MAPK, mTOR, HIF-1, and VEGF. In vivo, BTPS&pDA@PGHExo improved bone volume, density, and neovascularization in a rabbit model. This dual biomimetic strategy offers a promising clinical solution, addressing the limitations of conventional Ti-6Al-4V scaffolds and providing an innovative approach for personalized bone defect repair.}, archive = {J_ADVS}, author = {Lincong Luo and Weihan Zheng and Jiaying Li and Tingting Chen and Wanting Xue and Tao Lin and Mingrui Liu and Zi Yan and Jiaxin Yang and Jiamin Li and Jiahao Pu and Yaobin Wu and Konghe Hu and Shiyu Li and Wenhua Huang}, doi = {10.1002/advs.202500599}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500599}, shortjournal = {Adv. Sci.}, title = {3D-printed titanium trabecular scaffolds with sustained release of hypoxia-induced exosomes for dual-mimetic bone regeneration}, volume = {12}, year = {2025}, }
• (2025). CCN1 enhances tumor immunosuppression through collagen-mediated chemokine secretion in pancreatic cancer. ADVS, 12(23), 2500589. (www)

  @article{ , abstract = {Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense, immunosuppressive tumor microenvironment (TME) that limits therapeutic efficacy. This study investigates the role of cellular communication network factor 1 (CCN1, also known as Cyr61), an extracellular matrix-associated protein, in modulating the TME of PDAC. It is demonstrated that Ccn1 promotes PDAC progression by upregulating collagen and chemokine expression, thereby facilitating immune cell exclusion and enhancing tumor growth. Using a Ccn1-deficient PDAC model, decreased collagen and chemokine levels are observed, resulting in increased infiltration of cytotoxic immune cells and reduced myeloid-derived suppressor cells (MDSCs). Furthermore, Ccn1-deficient tumors exhibit heightened sensitivity to gemcitabine and show enhanced responsiveness to anti-programmed cell death 1 (anti-PD1) therapy. Mechanistically, Ccn1 regulates chemokine production through collagen expression, with chemokine levels remaining suppressed even upon interferon-gamma treatment in collagen-deficient cells. These findings highlight Ccn1 as a potential therapeutic target that reprograms the TME to enhance the efficacy of both chemotherapy and immunotherapy in PDAC, providing a novel approach for overcoming immune resistance in PDAC.}, archive = {J_ADVS}, author = {Hongjie Fan and Huzi Zhao and Lili Gao and Yucheng Dong and Pei Zhang and Pengfei Yu and Yunfei Ji and Zhe-Sheng Chen and Xinmiao Liang and Yang Chen}, doi = {10.1002/advs.202500589}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500589}, shortjournal = {Adv. Sci.}, title = {CCN1 enhances tumor immunosuppression through collagen-mediated chemokine secretion in pancreatic cancer}, volume = {12}, year = {2025}, }
• (2025). Explainable deep multilevel attention learning for predicting protein carbonylation sites. ADVS, 12(23), 2500581. (www)

  @article{ , abstract = {Protein carbonylation refers to the covalent modification of proteins through the attachment of carbonyl groups, which arise from oxidative stress. This modification is biologically significant, as it can elicit modifications in protein functionality, signaling cascades, and cellular homeostasis. Accurate prediction of carbonylation sites offers valuable insights into the mechanisms underlying protein carbonylation and the pathogenesis of related diseases. Notably, carbonylation sites and ligand interaction sites, both functional sites, exhibit numerous similarities. The survey reveals that current computation-based approaches tend to make excessive cross-predictions for ligand interaction sites. To tackle this unresolved challenge, selective carbonylation sites (SCANS) is introduced, a novel deep learning-based framework. SCANS employs a multilevel attention strategy to capture both local (segment-level) and global (protein-level) features, utilizes a tailored loss function to penalize cross-predictions (residue-level), and applies transfer learning to augment the specificity of the overall network by leveraging knowledge from pretrained model. These innovative designs have been shown to successfully boost predictive performance and statistically outperforms current methods. Particularly, results on benchmark testing dataset demonstrate that SCANS consistently achieves low false positive rates, including low rates of cross-predictions. Furthermore, motif analyses and interpretations are conducted to provide novel insights into the protein carbonylation sites from various perspectives.}, archive = {J_ADVS}, author = {Jian Zhang and Jingjing Qian and Pei Wang and Xuan Liu and Fuhao Zhang and Haiting Chai and Quan Zou}, doi = {10.1002/advs.202500581}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500581}, shortjournal = {Adv. Sci.}, title = {Explainable deep multilevel attention learning for predicting protein carbonylation sites}, volume = {12}, year = {2025}, }
• (2025). An ultra-fast rolling double-helical robot driven by constant humidity. ADVS, 12(23), 2500577. (www)

  @article{ , abstract = {Untethered soft robots made of stimuli-responsive materials hold great application potential in various fields. However, most robots of this type require artificial modulation of the stimuli to actuate, while it is a great challenge to achieve fast periodic locomotion under a constant external environment. Here, a double-helical robot constructed with humidity-sensitive agarose (AG) films, referred to as the Dualicalbot is proposed, which can rapidly roll under a constant humid environment by making two helices alternately bend by absorbing humidity to actuate the robot in two half-cycles. A theoretical model is built to unveil the periodic deformation of the robot as well as the correlation between the design parameters and the motion speed, based on which the Dualicalbot can reach a maximum rolling speed of 5.8 BL s −1 . Moreover, it is capable of carrying a payload up to 100% of self-weight and detecting the acid environment it rolls through. This work is envisaged, and more generally the structural design and theoretical modeling principle, will open a new avenue for the development of advanced soft robotics with diverse functionalities.}, archive = {J_ADVS}, author = {Chuhan Xu and Jiayao Ma and Lei Fu and Xinmeng Liu and Lei Zhang and Yan Chen}, doi = {10.1002/advs.202500577}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500577}, shortjournal = {Adv. Sci.}, title = {An ultra-fast rolling double-helical robot driven by constant humidity}, volume = {12}, year = {2025}, }
• (2025). Dipyridamole acts as clinical ferroptosis inhibitor to prevent from tissue injury. ADVS, 12(23), 2500566. (www)

  @article{ , abstract = {Ferroptosis is a newly identified cell death triggered by iron-induced lipid peroxidation. Numerous studies reveal that ferroptosis participates in multiple types of tissue injury including ischaemia–reperfusion (I/R) injury and doxorubicin (Dox)-induced damage. Targeting ferroptosis is a promising approach for disease treatment as the blockade of ferroptosis efficiently alleviates the symptoms. However, no known ferroptosis inhibitors have been used for clinical treatment. Although certain clinical compounds act as ferroptosis inhibitors in vitro, whether these drugs cure tissue injury by suppressing ferroptosis is little known. Here, by screening a large panel of drugs used in the clinic, it is identified that dipyridamole significantly attenuates Dox or I/R-induced cardiac injury. Moreover, dipyridamole can achieve a good therapeutic effect on  liver and kidney injury. Mechanistically, dipyridamole-mediated ferroptosis inhibition is strictly dependent on solute carrier family 7 member 11 (SLC7A11). Dipyridamole down-regulates the expression of ring finger protein 126 (RNF126), which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. Deficiency of SLC7A11 largely blocks the protective role of dipyridamole in vitro and in vivo. Together, the findings uncover that dipyridamole acts as a clinical compound to alleviate organ injury via suppressing ferroptosis, providing novel insights into the clinical therapy for ferroptosis-related tissue damage.}, archive = {J_ADVS}, author = {Xiao Zhuang and Shuang Shi and Shuo Liu and Yaqiong Jiao and Bin Huang and Yinghong Yang and Li Yang and Xinquan Yang and Hui Wang and Chunhui Liang and Dandan Song and Huaxiang Yu and Dan Zou and Qi Sun and Shu Yang and Chengqian Yin and Jian Li and Yiming Liu and Junxia Min and Fudi Wang and Yong Nian and Lutao Du and Bo Chu}, doi = {10.1002/advs.202500566}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500566}, shortjournal = {Adv. Sci.}, title = {Dipyridamole acts as clinical ferroptosis inhibitor to prevent from tissue injury}, volume = {12}, year = {2025}, }
• (2025). Erythropoietin-stimulated macrophage-derived extracellular vesicles in chitosan hydrogel rescue BMSCs fate by targeting EGFR to alleviate inflammatory bone loss in periodontitis. ADVS, 12(23), 2500554. (www)

  @article{ , abstract = {Loss of periodontal tissue due to persistent inflammation in periodontitis is a major cause of tooth loss in adults. Overcoming osteogenic inhibition in the inflammatory periodontal environment and restoring the regenerative capacity of endogenous bone marrow mesenchymal stem cells (BMSCs) remain critical challenges in current treatment approaches. Macrophage-derived extracellular vesicles (EVs) are key regulators of osteogenesis in recipient cells, yet the role of erythropoietin (EPO) in modifying macrophages and the function of their EVs in bone regeneration remain unclear. In this study, EVs from EPO-stimulated macrophages (EPO-EVs) are isolated, and they are encapsulated in a chitosan/β-sodium glycerophosphate/gelatin (CS/β-GP/gelatin) hydrogel to create a controlled-release EVs delivery system for localized periodontal environment. EPO-EVs restore the osteogenic function of mouse BMSCs (mBMSCs) and mitigate inflammatory bone loss in a periodontitis mouse model. Mechanistically, miR-5107-5p, significantly enriched in EPO-EVs, is delivered to mBMSCs, where it suppresses epidermal growth factor receptor (EGFR) expression and alleviates EGFR's inhibitory effect on RhoA. This process counteracts osteogenic inhibition in inflammatory settings through the EGFR/RhoA axis. Overall, EVs from EPO pretreated macrophages restore the osteogenic capacity of mBMSCs under inflammation by inhibiting EGFR expression, providing new insight into therapeutic mechanisms and offering a promising approach for future periodontitis treatment.}, archive = {J_ADVS}, author = {Shuchen Liu and Zhuoran Wang and Yuhuan Li and Ziyi Pan and Lei Huang and Jing Cui and Xue Zhang and Mingxi Yang and Yuan Zhang and Daowei Li and Hongchen Sun}, doi = {10.1002/advs.202500554}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500554}, shortjournal = {Adv. Sci.}, title = {Erythropoietin-stimulated macrophage-derived extracellular vesicles in chitosan hydrogel rescue BMSCs fate by targeting EGFR to alleviate inflammatory bone loss in periodontitis}, volume = {12}, year = {2025}, }
• (2025). Atomic-level strain sensing and piezoresistance effect in a 1D single-atom chain. ADVS, 12(23), 2500553. (www)

  @article{ , abstract = {Small variations in interatomic distances have a substantial impact on the physical and chemical properties of nanomaterials. Investigating these effects offers a deeper understanding of the mechanisms governing the behavior of nanomaterials and nanostructures, providing foundations for the design and optimization of novel functional materials. However, the impact of strain in single-atom structures on piezoresistance and electronic transport properties remains unclear. This study focuses on a 1D, dynamic functional nanostructure that uses interatomic distance variations for lattice-level strain sensing. This silver (Ag) atom chain shows a high stability at room-temperature and an exceptional piezoresistance coefficient, enabling the detection of structural changes at atomic radius scale with high sampling frequencies. It is considered that this strong piezoresistivity is due to the impact of interatomic distance on electron scattering and transport mechanisms. The density functional theory simulations of electron transport reveal that variations in interatomic distance significantly influence the relaxation time of electron scattering and the effective electron mass, thereby modulating the characteristics of electron transport. This 1D dynamic nanostructure has the potential to address the low time resolution limitations of transmission electron microscopy (TEM), enhancing its capabilities for in situ characterization and multi-physical-field sensing. This study provides experimental evidence for insights into atomic scale piezoresistivity and underlying mechanisms.}, archive = {J_ADVS}, author = {Zhi Qu and Wenqi Zhang and Shuideng Wang and Donglei Chen and Yiqing Yao and Mingxing Cheng and Lixin Dong}, doi = {10.1002/advs.202500553}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500553}, shortjournal = {Adv. Sci.}, title = {Atomic-level strain sensing and piezoresistance effect in a 1D single-atom chain}, volume = {12}, year = {2025}, }
• (2025). Dual role of CRABP2 in colorectal cancer: Oncogenesis via nuclear RB1 and cytoplasmic AFG3L2/SLC25A39 axis, while limiting liver metastasis through cytoplasmic AFG3L2/PINK1/Parkin-mediated mitophagy. ADVS, 12(23), 2500552. (www)

  @article{ , abstract = {Colorectal cancer (CRC) progression and metastasis involve numerous regulatory factors. Among these, cellular retinoic acid-binding protein 2 (CRABP2) has been implicated as both a tumor activator and suppressor. Here, it is aimed to clarify the role of CRABP2 in CRC growth and metastasis and explore the underlying molecular mechanisms mediating its cellular functions. Using both in vitro and in vivo models, including a colonocyte-specific CRABP2 conditional knockout mouse model ( Crabp2 ΔIEC ) and a subcutaneous tumorigenesis assay in BALB/c nude mice, it is shown that nuclear CRABP2 enhances tumor growth by interacting with and downregulating the tumor suppressor RB1, whereas cytoplasmic CRABP2 suppresses CRC liver metastasis by interacting with AFG3L2 and promoting mitophagy. In addition, the AFG3L2–SLC25A39 axis is identified as a distinct mechanism by which cytoplasmic CRABP2 increases mitochondrial glutathione stability to promote cell proliferation independent of the nuclear RB1 pathway. Notably, analysis of tissue from CRC patients reveals that CRABP2 protein has distinct prognostic implications and functional roles in the progression and metastasis of CRC dependent on its subcellular localization. Ultimately, by elucidating the role of CRABP2 in CRC, it is aimed to provide new insight into disease pathogenesis and inform the development of therapeutic interventions.}, archive = {J_ADVS}, author = {Chuanxin Tian and Sheng Yang and Chuan Zhang and Renzhong Zhu and Chen Chen and Xiaowei Wang and Dongsheng Zhang and Qingyang Sun and Hengjie Xu and Hongxu Nie and Yue Zhang and Dongjian Ji and Junwei Tang and Kangpeng Jin and Yueming Sun}, doi = {10.1002/advs.202500552}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500552}, shortjournal = {Adv. Sci.}, title = {Dual role of CRABP2 in colorectal cancer: Oncogenesis via nuclear RB1 and cytoplasmic AFG3L2/SLC25A39 axis, while limiting liver metastasis through cytoplasmic AFG3L2/PINK1/Parkin-mediated mitophagy}, volume = {12}, year = {2025}, }
• (2025). Surface and bulk defect passivation in MAPbI3 perovskites with daminozide: Effects on carrier dynamics and mobility. ADVS, 12(23), 2500530. (www)

  @article{ , abstract = {Metal halide perovskite semiconductors are highly valued for their outstanding optoelectronic properties. However, the high density of intrinsic defect states in their polycrystalline thin films on the surface and within the bulk poses a significant challenge by diminishing carrier mobility and lifetime, thus hindering device performance. This study reveals a previously unidentified mid-IR emissive trapping state in MAPbI 3 that differs from conventional Shockley-Read-Hall (SRH) defects, exhibiting unique surface-localized characteristics detectable through transient mid-IR spectroscopy. A dual-function passivation strategy using daminozide (DA) is developed, where the interlayer selectively passivates mid-IR-active surface defects while the additive mitigates bulk SRH defects through carbonyl-Pb 2 ⁺ coordination. This passivation strategy yields remarkable improvements in carrier dynamics, increasing diffusion constants from 0.135 to 0.165 cm 2 s⁻¹ and significantly enhancing the device performance, including open-circuit voltage and power conversion efficiency. These findings highlight the crucial importance of addressing both surface and bulk defects to optimize the optoelectronic properties of perovskites.}, archive = {J_ADVS}, author = {Junhan Xie and Di Li and Haozheng Li and Bo Peng and Qinye Bao and Jiaming Jiang and Bo Li and Weimin Liu}, doi = {10.1002/advs.202500530}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500530}, shortjournal = {Adv. Sci.}, title = {Surface and bulk defect passivation in MAPbI3 perovskites with daminozide: Effects on carrier dynamics and mobility}, volume = {12}, year = {2025}, }
• (2025). Photonic bayesian neural networks: Leveraging programmable noise for robust and uncertainty-aware computing. ADVS, 12(23), 2500525. (www)

  @article{ , abstract = {Photonic neural networks (PNNs) based on silicon photonic integrated circuits (Si-PICs) offer significant advantages over microelectronic counterparts, including lower energy consumption, higher bandwidth, and faster computing speeds. However, the analog nature of optical signal in PNNs makes Si-PIC solutions highly sensitive to device noise, especially when using fixed-value deterministic models, which are not robust to hardware fluctuation. Furthermore, current PNNs are unable to handle data uncertainty, a critical factor in applications such as autonomous driving, medical diagnostics, and financial forecasting. Herein, a photonic Bayesian neural network (PBNN) architecture that incorporates Bayesian principles to enhance robustness and address uncertainty is proposed. In the PBNN, device noise is leveraged through photonic-noise-based random number generators, which combine Mach-Zehnder interferometers and micro-ring resonators to independently control output mean and standard deviation. Based on modelling with experimentally extracted data, the PBNN achieves a classification accuracy of up to 98% for handwritten digit recognition, matching full-precision models on conventional computers. Beyond classification, the PBNN excels in multimodal data processing, regression, and outlier detection. This scalable, energy-efficient architecture transforms photonic noise into computational value, addressing the limitations of deterministic PNNs and enabling uncertainty-aware computing for real-world applications.}, archive = {J_ADVS}, author = {Yangyang Zhuge and Zhihao Ren and Zian Xiao and Zixuan Zhang and Xinmiao Liu and Weixin Liu and Siyu Xu and Chong Pei Ho and Nanxi Li and Chengkuo Lee}, doi = {10.1002/advs.202500525}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500525}, shortjournal = {Adv. Sci.}, title = {Photonic bayesian neural networks: Leveraging programmable noise for robust and uncertainty-aware computing}, volume = {12}, year = {2025}, }
• (2025). Ti3C2Tx MXene-zirconium diboride based ultra-high temperature ceramics. ADVS, 12(23), 2500487. (www)

  @article{ , abstract = {MXenes are a family of two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides with potential applications in ceramics and composites due to their nanometer-thick morphology, hydrophilic surfaces, and negative zeta potentials. In this study, we investigated titanium carbide MXene (Ti 3 C 2 T x ) as an additive in ultra-high-temperature ceramics (UHTCs), specifically zirconium diboride (ZrB 2 ). Homogeneous green bodies of Ti 3 C 2 T x and ZrB 2 were synthesized via electrostatic self-assembly in aqueous media without surfactants and subsequently densified using field-assisted (spark plasma) sintering. The incorporation of 0.5 wt.% MXene enhanced the relative density of ZrB 2 from ≈89% (pure ZrB 2 ) to ≈96% under identical sintering conditions. MXene addition significantly reduced the oxygen content from ≈5 at.% in pure ZrB₂ to ≈2–3 at.% at 2.5 wt.% MXene loading. The presence of MXene also facilitates the formation of a core–shell microstructure, where (Zr,Ti)B 2 shells encapsulate ZrB₂ cores, with arrays of dislocations observed at the core–shell interface. Mechanical characterizations show substantial improvements, including a 36% increase in hardness, a ≈12% enhancement in Young's modulus, and a ≈15% increase in flexural strength at 2.5 wt.% MXene loading. These findings demonstrate the potential of MXenes as effective sintering aids and reinforcement agents in UHTCs, offering promising pathways for advancing materials designed for extreme environments.}, archive = {J_ADVS}, author = {Srinivasa Kartik Nemani and Nicola Gilli and Steven Goldy and Ankit Kumar and Yooran Im and Austin J. Vorhees and Brian C. Wyatt and Nithin Chandran BS and Nikhilesh Chawla and Garritt J. Tucker and Laura Silvestroni and Babak Anasori}, doi = {10.1002/advs.202500487}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500487}, shortjournal = {Adv. Sci.}, title = {Ti3C2Tx MXene-zirconium diboride based ultra-high temperature ceramics}, volume = {12}, year = {2025}, }
• (2025). Hydrogel-transformable probiotic powder for targeted eradication of helicobacter pylori with enhanced gastric mucosal repair and microbiota preservation. ADVS, 12(23), 2500478. (www)

  @article{ , abstract = {Lactobacillus reuteri ( L. reuteri ) therapies represent a potentially effective approach to eradicating Helicobacter pylori (H. pylori) . However, the difficulty in bacterial viability preservation and harsh gastric environment compromises the survival and on-target delivery of L. reuteri . This study presents a novel bacterium-mediated bacterial elimination strategy using an edible L. reuteri @HTP probiotic powder for targeted bacterial elimination. The probiotic powder is obtained by grinding a lyophilized hydrogel composed of L. reuteri , hyaluronic acid (HA), tannic acid (TA), and polyvinyl alcohol (PVA). Upon contact with water, the powder quickly transforms into a hydrogel, enhancing L. reuteri ’s survival in the harsh gastric environment and ensuring selective release at H. pylori -infected inflammatory sites. L. reuteri targets and reduces H. pylori colonization while secreting reuterin to eliminate the bacteria. Additionally, TA's antioxidant properties help alleviate inflammation, and HA supports gastric mucosal repair. L. reuteri @HTP powder preserves the integrity of the gut microbiota, facilitating the restoration of a healthy microbiome. In particular, the probiotic powder remains stable at room temperature for at least six months, providing a promising alternative to traditional antibiotics for H. pylori treatment. This strategy combines targeted eradication, mucosal healing, and microbiome restoration, offering a new approach to treating gastric infections.}, archive = {J_ADVS}, author = {Yongkang Lai and Hanchun Shen and Shige Wang and Yongliang Ouyang and Xinyuan Zhang and Bin Hu and Xiaoyi Zhang and Guisheng Li and Lizhi Xu and Jiulong Zhao}, doi = {10.1002/advs.202500478}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500478}, shortjournal = {Adv. Sci.}, title = {Hydrogel-transformable probiotic powder for targeted eradication of helicobacter pylori with enhanced gastric mucosal repair and microbiota preservation}, volume = {12}, year = {2025}, }
• (2025). Identification of CD38high monocyte as a candidate diagnostic biomarker and therapeutic target for sepsis. ADVS, 12(23), 2500457. (www)

  @article{ , abstract = {Sepsis is characterized by a systemic host response to infection. Monocytes, as major mediators of acute infection, are implicated in complications among critically ill patients. Identifying key monocyte subsets and their activation states is essential for diagnosis and delineating new therapeutic targets for sepsis. Here, single cell transcriptome sequencing and mass cytometry are used to assess alterations in the composition and function of peripheral monocytes of patients with sepsis, and CD38 high monocytes in circulation are specifically accumulated within the first 24 h of sepsis. CD38 high monocytes are detectable by conventional flow cytometry to discriminate sepsis and sterile inflammation, and are associated with 28-day mortality in bacterial sepsis. Targeting CD38 therapy markedly reduces inflammatory response in primary monocytes and in sepsis mice model. Mechanistically, CD38 high monocytes in sepsis exhibit hyperactivated glycolysis with activation of hypoxia-inducible factor-1α (HIF-1α) due to NAD + consumption. Glycolytic metabolite methylglyoxal (MGO) is found to regulate expression of CD38, establishing a CD38-HIF-1α/glycolysis/MGO loop that exacerbates sepsis-induced immune dysregulation. These findings demonstrate that CD38 high monocytes might serve as a candidate diagnostic biomarker and therapeutic target for sepsis.}, archive = {J_ADVS}, author = {Ning Hua and Limin Kong and Li Fan and Yanan Bai and Yujun Zhou and Yanfang Zhang and Qingwei Zhao and Xiaoyang Lu and Hongyu Yang and Hangyang Li and Peili Ding and Yuyu Nan and Qinghua Ji and Ping Yang and Lu Li and Yijing Xin and Lijuan Zhao and Wei Yang and Wenqiao Yu and Saiping Jiang}, doi = {10.1002/advs.202500457}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500457}, shortjournal = {Adv. Sci.}, title = {Identification of CD38high monocyte as a candidate diagnostic biomarker and therapeutic target for sepsis}, volume = {12}, year = {2025}, }
• (2025). Giant modulation of interlayer coupling in twisted bilayer ReS2. ADVS, 12(23), 2500411. (www)

  @article{ , abstract = {Stacking monolayers of two-dimensional (2D) transition metal dichalcogenides with different twist angles can provide a way to tune their quantum optical and electronic characteristics. This study demonstrates that the bandgap energy and interlayer coupling strength of twisted bilayer (tBL) ReS 2 can be continuously modulated by the twist angle. By controlling the twist angle between 0° and 10°, the exciton energy of tBL ReS 2 is tuned over a range of 40 meV, which is comparable to the difference between the exciton energies of intrinsic monolayer and bilayer ReS 2 . Such a wide modulation range for the interlayer coupling strength of tBL ReS 2 , which significantly affects the band structure, is also shown by the systematic shift in the low-and high-frequency Raman modes and results of a strain study using scanning transmission electron microscopy imaging. Density functional theory calculations on moiré superlattice tBL ReS 2 structures confirm a consistent increase in the bandgap with the twist angle. The strong modulation of interlayer coupling by the twist angle in tBL ReS 2 is attributed to the low symmetry of the 1T ' structure and in-plane anisotropy of the ReS 2 lattice. These findings demonstrate the enhanced tunability of twist-controlled electronic structure in anisotropic 2D materials, offering new pathways for designing reconfigurable quantum materials.}, archive = {J_ADVS}, author = {Krishna P. Dhakal and Trang Thu Tran and Taegeon Lee and Wooseon Choi and Sean F. Peterson and Juan M. Marmolejo-Tejada and Jaeuk Bahng and Daekwon Lee and Vu Khac Dat and Ji-Hee Kim and Seong Chu Lim and Martín A. Mosquera and Young-Min Kim and Heesuk Rho and Jeongyong Kim}, doi = {10.1002/advs.202500411}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500411}, shortjournal = {Adv. Sci.}, title = {Giant modulation of interlayer coupling in twisted bilayer ReS2}, volume = {12}, year = {2025}, }
• (2025). Energy dispersion induced precisely tunable friction of graphitic interface. ADVS, 12(23), 2500378. (www)

  @article{ , abstract = {Precise control of friction at the nanoscale is crucial for developing efficient micro/nano-electromechanical systems. This study presents a novel approach to manipulate friction in two-dimensional materials using coupled direct current (DC) and alternating current (AC) electric fields. By applying a low-amplitude AC bias atop a DC field, friction on monolayer graphene is continuously reduced without compensating the DC bias, while preserving the integrity of the graphitic interface. Theoretical analysis through the generalized Prandtl–Tomlinson model reveals a unique energy dispersion mechanism, where vertical resonance absorbs horizontal energy, minimizing sliding friction and enhancing interfacial durability. This approach addresses limitations in conventional electrically controlled friction methods, enabling precise device manipulation and offering new insights into frictional behavior and energy transmission.}, archive = {J_ADVS}, author = {Zhao Liu and Hang Yang and Sen Wang and Jinxiong Wu and Wengen Ouyang and Junyan Zhang and Feng Luo}, doi = {10.1002/advs.202500378}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500378}, shortjournal = {Adv. Sci.}, title = {Energy dispersion induced precisely tunable friction of graphitic interface}, volume = {12}, year = {2025}, }
• (2025). Natural crystal structure for generating raman-like orbital angular momentum states. ADVS, 12(23), 2500377. (www)

  @article{ , abstract = {Creation of structured light at-source with determinate orbital angular momentum (OAM) states is a fascinating branch of modern optics, owing to their integrability, wavelength insensitivity, and high mode purity. However, mode degeneracy in spatially column-symmetric cylindrical coordinate systems leads to a total zero OAM states which seriously limits their development and applications. Here, a strategy is proposed for symmetry breaking of the degenerate OAM states relying on the natural anisotropy of crystal gain, to select the handedness of the spatial spiral phase front and further tunable Raman-like OAM states by thermal-driven, experimentally realized arbitrary OAM states from −2 ћ to ћ . The concept presented herein clarifies the contribution of intrinsic crystal property to the OAM states and opens a new route for an at-source solution of structure light with high integrability and controllable OAM states.}, archive = {J_ADVS}, author = {Tianxiang Meng and Changsheng Zheng and Yongguang Zhao and Haohai Yu and Huaijin Zhang}, doi = {10.1002/advs.202500377}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500377}, shortjournal = {Adv. Sci.}, title = {Natural crystal structure for generating raman-like orbital angular momentum states}, volume = {12}, year = {2025}, }
• (2025). SMC4 promotes prostate cancer cell proliferation and metastasis via the Rheb/mTOR pathway. ADVS, 12(23), 2500369. (www)

  @article{ , abstract = {Structural maintenance of chromosome protein 4 (SMC4), is a key structural component of mitotic chromosomes. While existing evidence indicates a plausible link between SMC4 and oncogenic manifestations, its precise role in the trajectory of prostate cancer remains ambiguous. The Cancer Genome Atlas (TCGA) database analysis reveals that aberrant expression of SMC4 exhibits a robust prognostic association with metastatic progression. To investigate the function of SMC4, the SMC4 gene is knocked down in RM1-LM cells, a highly metastatic cell clone is developed, using the CRISPR/Cas9 system. The results show that SMC4 knockdown significantly diminished cell proliferation and migration in vitro. Furthermore, in a murine model, RM1-LM cells display higher lung metastasis capabilities than SMC4 knockdown cells. SMC4 knockdown inhibited the activation of mTOR and downregulated the expression of Rheb. KEGG enrichment analyses of the RNA-seq results reveal that cancer signaling pathways and metabolic pathways are enriched. The SMC4 interactome is uncovered through IP-MS and indicates that SMC4 interacts with GLUT1, encoded by Slc2a1 . Glycolytic rate assay illustrates that knocking down SMC4 inhibits the cell glycolysis rate and ATP production. Collectively, the data suggests that the interaction between SMC4 and GLUT1, as confirmed by co-IP, promotes prostate cancer cell metastasis through the Rheb/mTOR pathway.}, archive = {J_ADVS}, author = {Wei Zhang and Siyuan Qin and Xiaokang Li and Ming Chang and Tianzi Wei and Xin Huang and Haibo Tong and Xia Guo and Yi Lu and Jian Zhang}, doi = {10.1002/advs.202500369}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500369}, shortjournal = {Adv. Sci.}, title = {SMC4 promotes prostate cancer cell proliferation and metastasis via the Rheb/mTOR pathway}, volume = {12}, year = {2025}, }
• (2025). Pia mater-penetrable lipopolymer nanoparticles for gliocyte-targeted IL-10 mRNA therapy alleviate paclitaxel-induced peripheral neuropathy. ADVS, 12(23), 2500362. (www)

  @article{ , abstract = {Paclitaxel (PTX) is a commonly used chemotherapeutic agent for treating various solid tumors; however, it often leads to a severe side effect known as paclitaxel-induced peripheral neuropathy (PIPN), for which effective treatments are limited. Although mRNA therapies have shown promise in addressing central nervous system (CNS) disorders, the successful delivery of mRNA therapeutics to the nervous system is still hindered by many biological barriers. In this study, it is demonstrated that, compared with commercial MC3 lipid nanoparticles (MC3 LNPs), mRNA-loaded P6CIT-derived lipopolymer nanoparticles (P6CIT LPNPs), which are delivered via intrathecal injection, achieve effective penetration through the pia mater. More importantly, this P6CIT LPNP demonstrates the ability to achieve highly targeted mRNA transfection in gliocytes within the spinal cord and dorsal root ganglia (DRG), which is essential for the regulation of neuroinflammation. Furthermore, two intrathecal injections of P6CIT LPNPs encapsulating mIL-10 (P6CIT/mIL-10) significantly alleviate PIPN by reducing proinflammatory cytokine production, gliocyte activation, and presynaptic NMDA receptor hyperactivity in both male and female mice. This study presents a promising and clinically translatable platform for using mRNA-loaded LPNPs to treat PIPN.}, archive = {J_ADVS}, author = {Xinrou Lin and Lingyu Wei and Xiangpen Li and Ling Zeng and Yingsen Tang and Hongjin Wang and Hengjian Lu and Chenguang Li and Hongxuan Wang and Jinjin Chen and Ying Peng}, doi = {10.1002/advs.202500362}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500362}, shortjournal = {Adv. Sci.}, title = {Pia mater-penetrable lipopolymer nanoparticles for gliocyte-targeted IL-10 mRNA therapy alleviate paclitaxel-induced peripheral neuropathy}, volume = {12}, year = {2025}, }
• (2025). A self-assembling LYTAC mediates CTGF degradation and remodels inflammatory tumor microenvironment for triple-negative breast cancer therapy. ADVS, 12(23), 2500311. (www)

  @article{ , abstract = {As a multifunctional extracellular protein, connective tissue growth factor (CTGF/CCN2) is significantly associated with the progression and prognosis of triple-negative breast cancer (TNBC). However, current blockade therapies targeting CTGF's multiple domains are limited, creating substantial challenges in treatment. Lysosome-targeting chimeras (LYTACs) have emerged as a promising approach for achieving complete protein degradation and inhibiting CTGF's various bioactivities. In this study, a self-assembling LYTAC nanoplatform, NanoCLY, designed to tumor microenvironment (TME)-responsively degrade CTGF is presented. The complete degradation of CTGF downregulates the TGF-β signaling pathway and disrupts the CTGF-IL-6 cell crosstalk within the TME, which further inhibits the activation of inflammatory cancer-associated fibroblasts (CAFs) and alleviates the inflammatory TME. Notably, the anti-TNBC effect of LYTAC-based CTGF degradation therapy surpasses that of antibody-based blockade therapy in both in vitro and in vivo models. The findings provide a proof of concept for CTGF degradation in TNBC and introduce the first CTGF-LYTAC nanoplatform aimed at TME-directed therapy.}, archive = {J_ADVS}, author = {Jia-Yi Lin and Ye Wu and Xiao-Hui Liang and Min Tang and Xin Sun and Sheng-Xin Lu and Jin-Mei Jin and Xin Guo and Bei Wang and Hong-Zhuan Chen and Wei-Dong Zhang and Xin Luan}, doi = {10.1002/advs.202500311}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500311}, shortjournal = {Adv. Sci.}, title = {A self-assembling LYTAC mediates CTGF degradation and remodels inflammatory tumor microenvironment for triple-negative breast cancer therapy}, volume = {12}, year = {2025}, }
• (2025). AlphaFold-guided bespoke gene editing enhances field-grown soybean oil contents. ADVS, 12(23), 2500290. (www)

  @article{ , abstract = {Enhancing the oil or protein content of soybean, a major crop for oil and protein production is highly desirable. GmSWEET10a encodes a sugar transporter that is strongly selected during domestication and breeding, increasing seed size and oil content. GmSWEET10b is functionally similar to GmSWEET10a, yet has not been artificially selected. Here, AlphaFold is used to find that C-terminal variants of GmSWEET10a can endow enhanced or reduced transport activity. Guided by AlphaFold, the functionality is improved for GmSWEET10a in terms of oil content through gene editing. Furthermore, novel GmSWEET10b haplotypes possessing strengthened or weakened sugar-transport capabilities that are absent in nature are engineered. Consequently, soybean oil content or protein content in independent GmSWEET10b gene-edited lines during multi-year and multi-site field trials is consistently increased, without negatively affecting yield. The study demonstrates that the combination of AlphaFold-guided protein design and gene editing has the potential to generate novel beneficial alleles, which can optimize protein function in the context of crop breeding.}, archive = {J_ADVS}, author = {Jie Wang and Li Zhang and Shoudong Wang and Xin Wang and Suning Li and Pingping Gong and Mengyan Bai and Arnav Paul and Nathan Tvedt and Hengrui Ren and Maoxiang Yang and Zhihui Zhang and Shaodong Zhou and Jiayi Sun and Xianjin Wu and Huaqin Kuang and Zhenghua Du and Yonghui Dong and Xiaolei Shi and Meina Li and Diwakar Shukla and Long Yan and Yuefeng Guan}, doi = {10.1002/advs.202500290}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500290}, shortjournal = {Adv. Sci.}, title = {AlphaFold-guided bespoke gene editing enhances field-grown soybean oil contents}, volume = {12}, year = {2025}, }
• (2025). Engineered genetic circuits activated by bezafibrate improve ESC-based TAA cancer vaccine efficacy and PD-l1 nanobody therapy. ADVS, 12(23), 2500272. (www)

  @article{ , abstract = {Immunotherapy targeting tumor antigens and immune checkpoint inhibitors has garnered significant attention in cancer treatment. Synthetic gene circuits are developed, encoded in plasmids, which regulate the expression of tumor antigens shared with embryonic stem cells (ESCs) and PD-L1 nanobody (PD-L1 nb) in response to bezafibrate stimulation. This approach significantly minimizes side effects and improved therapeutic efficacy. The transcriptional switches leverage the interaction between the bezafibrate-responsive transcriptional activator PPARγ and RXRα, which are fused with the VPR/VP64/p65 activation domains (AD) and the Gal4 DNA-binding domain (DBD), respectively. These synthetic constructs are validated and their ability to modulate gene expression upon bezafibrate treatment are confirmed. Notably, the gene expression is precise and tunable in response to bezafibrate administration. HEK293T cells or ESCs are employed to deliver this gene circuit, or the plasmids containing the circuit into the tumor are directly injected. Administration of bezafibrate reduces tumor growth, increases specific CD8 + T cells, and mitigates CD8 + T cell exhaustion, underscoring the feasibility and effectiveness of the approach. ESC-based and intratumoral delivery of the synthetic gene circuits and cargo genes, particularly PD-L1 nb, significantly inhibit tumor growth. PD-L1 nb effectively blocks PD-L1 expression both in vitro and in vivo, as confirmed by using a mutant PD-L1 nb sequence.}, archive = {J_ADVS}, author = {Meiling Jin and Shuzhen Liu and Mingshuo Zhan and Jian-Dong Huang}, doi = {10.1002/advs.202500272}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500272}, shortjournal = {Adv. Sci.}, title = {Engineered genetic circuits activated by bezafibrate improve ESC-based TAA cancer vaccine efficacy and PD-l1 nanobody therapy}, volume = {12}, year = {2025}, }
• (2025). Nanoconfinement engineering of covalent organic frameworks in polyamide membranes for high-perselectivity Li+/Mg2+ separation. ADVS, 12(23), 2500255. (www)

  @article{ , abstract = {Efficiently separating Li + over Mg 2+ from brines remains a significant challenge due to their minimal size difference of only several angstroms, posing a substantial difficulty for traditional nanofiltration (NF) membranes. Therefore, a nanoconfinement regulation strategy utilizing a porous covalent organic framework (COF) layer is proposed to precisely control the interfacial polymerization (IP) process, thereby obtaining a thin, uniform polyamide (PA) membrane for high-efficiency Li + /Mg 2+ separation. The nanoconfinement microenvironment fundamentally modulates both monomer spatial distribution and reaction kinetics through porous confined space and abundant interaction sites provided by the COF layer. Consequently, the resulting TpPa-S/PA membrane exhibits a narrower pore size distribution, achieving an ion sieving precision of 0.46 Å. Due to the strict size sieving effect, the Li + /Mg 2+ separation factor exceeded 120, which is one to two orders of magnitude higher than all the currently reported NF membranes. This study addressed the typical limitations inherent in conventional NF membranes, establishing a promising foundation for advancing lithium extraction technologies through nanoconfinement strategy-regulated IP processes.}, archive = {J_ADVS}, author = {Shuzhen Zhao and Liheng Dai and Zhaohuan Mai and Bowen Li and Pengfei Zhang and Mengxiao Zhang and Atsushi Matsuoka and Kecheng Guan and Ryosuke Takagi and Hideto Matsuyama}, doi = {10.1002/advs.202500255}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500255}, shortjournal = {Adv. Sci.}, title = {Nanoconfinement engineering of covalent organic frameworks in polyamide membranes for high-perselectivity Li+/Mg2+ separation}, volume = {12}, year = {2025}, }
• (2025). Locoregional immune checkpoint blockade and remodeling of lymph nodes by engineered dendritic cell-derived exosomes for suppressing tumor progression and metastasis. ADVS, 12(23), 2500139. (www)

  @article{ , abstract = {Tumor-draining lymph nodes (TDLNs) are the primary sites of eliciting anti-tumor immunity, which play an important role in controlling tumor progression and metastasis. However, the immunosuppressive microenvironment of TDLNs propels the formation of pre-metastatic niche, in which the immunocytes are dysfunctional, and the high expression of programmed death-ligand 1 (PD-L1) on dendritic cells (DCs) restricts the activation of cytotoxic T lymphocytes. Herein, engineered exosomes (EmDEX@GA) are developed for locoregional immunomodulation of TDLNs. EmDEX@GA possess CC-chemokine receptor 7 (CCR7) -dependent LN homing capacity and over-expressed programmed cell death protein 1 (PD-1) for immune checkpoint blockade (ICB). The loaded stimulator of interferon genes (STING) agonist can reinforce anti-tumor immunity through STING pathway activation. In orthotopic breast cancer mouse model, local administration of EmDEX@GA remodels the immunosuppressive microenvironment of TDLNs and elicits potent anti-tumor immunity, resulting in the suppression of tumor as well as the reduction of lymph node metastasis and distant metastasis. Compared with systemic ICB, local immunotherapy with EmDEX@GA has better therapeutic efficacy on suppressing distant metastasis. Moreover, the study suggests that the occurrences of distant metastasis are associated with the immunosuppressive microenvironment rather than the metastasis in TDLNs, indicating that targeted immunomodulation of TDLNs is necessary.}, archive = {J_ADVS}, author = {Yizhen Wang and Xiaomin Guo and Jingya Qin and Yifan Xue and Peng Zhang and Yadong Liu and Moyang Chen and Guanghao Zhu and Xinqiu Song and Lili Cheng and Bo Liu and Jie Liu and Jie Ren}, doi = {10.1002/advs.202500139}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500139}, shortjournal = {Adv. Sci.}, title = {Locoregional immune checkpoint blockade and remodeling of lymph nodes by engineered dendritic cell-derived exosomes for suppressing tumor progression and metastasis}, volume = {12}, year = {2025}, }
• (2025). Ligand-driven annular-epitaxial growth of CuS-au heterostructures as trinity plasmonic nanozyme for multimode diagnosis of pathogenic bacteria. ADVS, 12(23), 2500134. (www)

  @article{ , abstract = {This study presents a novel method to control the site-selective growth of Au nanostars on CuS nanodisc substrate, it indicates that the surfactant ligands play a key role in the architecture control, only CTAC and homologous series with appropriate affinity to CuS can direct the annular-epitaxial growth of Au nanoparticles on the CuS, which demonstrates superior peroxidase (POD)-mimic and SERS activity. Mechanistic studies indicate that plasmon-enhanced catalytic and SERS activity can be attributed to the spatially separated CuS-Au heterostructure, which supports the light-triggered hot electron-hole pairs production and localized surface plasmon resonance hotspots. For practical biosensing, the CuS-Au heterostructures assembled lateral flow assay (LFA) was used for SERS/catalytic colorimetric/photothermal three-mode detection of Streptococcus pneumoniae and Klebsiella pneumoniae , with visually colorimetric mode at 103 CFU/mL and quantitative SERS/photothermal modes at 2–10 2 CFU/mL within 15 min, 15 clinical samples were used to validate the assay, the result was 100% concordant to the results of quantitative real-time PCR. This study provides a unique avenue to controllably produce plasmon-enhanced nanozyme, which can provide multi-mode signals for LFA application and meet the requirements of different scenarios.}, archive = {J_ADVS}, author = {Xiaorui Lin and Pengyou Zhou and Miao An and Chenyi Zhu and Yuanfeng Pang and Rui Xiao}, doi = {10.1002/advs.202500134}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500134}, shortjournal = {Adv. Sci.}, title = {Ligand-driven annular-epitaxial growth of CuS-au heterostructures as trinity plasmonic nanozyme for multimode diagnosis of pathogenic bacteria}, volume = {12}, year = {2025}, }
• (2025). Nonaqueous electrolyte rechargeable manganese batteries with potassium manganese hexacyanoferrate cathodes. ADVS, 12(23), 2500132. (www)

  @article{ , abstract = {Manganese batteries garnered significant attention as sustainable and cost-effective alternatives to lithium-ion batteries. For the first time, manganese batteries are demonstrated using a manganese hexacyanoferrate cathode and organic electrolyte solution, specifically saturated Mn(ClO₄)₂ in acetonitrile. The manganese hexacyanoferrate cathode exhibits an average operating voltage of 1.7 V and a discharge capacity of 73.4 mAh g −1 at 0.1 A g −1 , retaining 71.1% capacity after 1500 cycles at 0.2 A g −1 . Diffusion pathways and barriers reveal efficient 3D Mn 2 ⁺ ion diffusion pathways within the manganese hexacyanoferrate framework, with a low migration barrier of 0.514 eV. Despite the promising performance, surface analysis of the Mn metal anode reveals the formation of complex organic/inorganic SEI (solid electrolyte interphase) layers, including MnO x , MnCl x , and organic compounds, due to electrolyte decomposition. These findings highlight the critical importance of SEI layer control and electrolyte optimization for enhancing the durability and efficiency of organic electrolyte-based manganese batteries. Manganese batteries are established as a viable next-generation energy storage solution and provide a foundation for further advancements in organic electrolyte-based battery systems.}, archive = {J_ADVS}, author = {Jangwook Pyun and Hyeonjun Lee and Seunghyeop Baek and Sangki Lee and Hyeju Kwon and Hyeongseok Lee and Chung-Yul Yoo and Munseok S. Chae}, doi = {10.1002/advs.202500132}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500132}, shortjournal = {Adv. Sci.}, title = {Nonaqueous electrolyte rechargeable manganese batteries with potassium manganese hexacyanoferrate cathodes}, volume = {12}, year = {2025}, }
• (2025). Genetically engineered IL12/CSF1R-macrophage membrane-liposome hybrid nanovesicles for NIR-II fluorescence imaging-guided and membrane-targeted mild photothermal-immunotherapy of glioblastoma. ADVS, 12(23), 2500131. (www)

  @article{ , abstract = {It is a big challenge for precision therapy of glioblastoma, mainly due to the existence of blood–brain barrier (BBB), tumor immunosuppressive microenvironment (TIM), and lack of efficient treatment paradigms. Herein, a theranostic nanoplatform for the second near-infrared window (NIR-II) fluorescence imaging-guided membrane-targeted mild photothermal-immunotherapy of glioblastoma using genetically engineered CSF1R/IL12-macrophage membrane (MM)-liposome hybrid nanovesicles, is reported. By mimicking lipophilic membrane probe (Dil) with octadecyl chains, a NIR-II emissive photothermal dye ( IRC18 ), which realizes labeling of nanovesicle lipid bilayers for biodistribution tracing, glioblastoma diagnosis, and molecular imaging of tumoral microenvironment, is synthesized. Importantly, MM and c-RGD-decorated liposome together offer BBB crossing, tumor targeting, and long-term circulation; while, the genetically overexpressed CSF1R and IL12 on MM surface contribute to effective modulation of M2-to-M1 macrophage repolarization and local promotion of T cell cytotoxicity in glioblastoma microenvironment, respectively. Notably, through membrane fusion, IRC18 dyes translocate from nanovesicle lipid bilayers to glioblastoma membranes, which achieve membrane-targeted mild photothermal therapy to ablate primary tumor and induce immunogenic cell death to promote antigen presentation. More importantly, the combined blockade of the CSF1-CSF1R axis and IL-12 enrichment not only reprograms the tumor microenvironment through macrophage M1 repolarization but also activates cytotoxic T cells, ultimately achieving complete glioblastoma eradication. This research provides an efficient theranostic paradigm for glioblastoma treatment.}, archive = {J_ADVS}, author = {Pengfei Chen and Yue Liu and Haiyan Huang and Menglong Li and Hui Xie and Shubham Roy and Jingsi Gu and Jian Jin and Kai Deng and Lixin Du and Bing Guo}, doi = {10.1002/advs.202500131}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500131}, shortjournal = {Adv. Sci.}, title = {Genetically engineered IL12/CSF1R-macrophage membrane-liposome hybrid nanovesicles for NIR-II fluorescence imaging-guided and membrane-targeted mild photothermal-immunotherapy of glioblastoma}, volume = {12}, year = {2025}, }
• (2025). Synergistic modulating of mitochondrial transfer and immune microenvironment to attenuate discogenic pain. ADVS, 12(23), 2500128. (www)

  @article{ , abstract = {Discogenic pain, caused by intervertebral disc degeneration (IVDD), is a prevalent and challenging condition to treat effectively. Macrophage infiltration with neural ectopic in-growth resulting from structural disturbances within the intervertebral disc (IVD) is a major cause of discogenic pain. This work systematically reveals how nanoparticles can synergistically regulate the immune microenvironment and mitochondrial communication to attenuate discogenic pain. The antioxidant metal-polyphenol nanoparticle system can sequentially regulate macrophage phenotype and mitochondrial delivery efficiency. This strategy circumvents the necessity for mitochondrial isolation and preservation techniques that are typically required in conventional mitochondrial transplantation procedures. Furthermore, it facilitates the effective and sustained delivery of mitochondria to damaged cells. In vivo, this nanoparticle formulation effectively preserves the IVD height, maintains the structural integrity of the nucleus pulposus (NP), and restores pain thresholds. Thus, this nanoplatform offers an effective approach to traditional surgical treatments for discogenic pain, with significant potential for clinical application.}, archive = {J_ADVS}, author = {Xinzhou Wang and Zhenyu Guo and Linjie Chen and Jing Sun and Kenny Yat Hong Kwan and Morgan Jones and Yan Michael Li and Yangyang Hu and Xueqiang Wang and Pooyan Makvandi and Xiangyang Wang and Qiuping Qian and Yunlong Zhou and Aimin Wu}, doi = {10.1002/advs.202500128}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500128}, shortjournal = {Adv. Sci.}, title = {Synergistic modulating of mitochondrial transfer and immune microenvironment to attenuate discogenic pain}, volume = {12}, year = {2025}, }
• (2025). Manipulating the light systemic signal HY5 greatly improve fruit quality in tomato. ADVS, 12(23), 2500110. (www)

  @article{ , abstract = {Fruit ripening in tomato fruits comprises dramatic metabolic changes that are regulated by environmental factors. Light not only drives photosynthesis but also acts as a critical signal regulating plant growth, development, and the quality of produce. However, it is unclear how plants sense light signals in the environment to regulate fruit quality. It is demonstrated that the accumulation of Long Hypocotyl 5 (HY5) protein peaks at the breaker stage of fruit maturity, independent of fruit bagging. Genetic manipulation of HY5 reveals that its knockout delays carotenoid synthesis and sucrose conversion, while its overexpression promotes fruit ripening. Molecular and biochemical analyses show that HY5 directly activates the transcript of the key carotenoid synthesis genes, such as Phytoene Synthase 1 (PSY1) and Phytoene Desaturase (PDS) , as well as the sucrose metabolism genes, including Lycopersicum Invertase ( LIN5 , LIN6 ), Vacuolar Invertase ( VI ) and Sucrose Synthase ( SS1 , SS7 ). Importantly, grafting experiments reveal that HY5 acts as a systemic signal, translocating from leaves to fruits to promote ripening. Furthermore, nightly lighting with red or blue LED greatly improves fruit quality. In summary, the results establish that HY5 as a mobile protein that mediates the systemic light regulation of fruit ripening, offering practical applications for improving fruit quality.}, archive = {J_ADVS}, author = {Jiachun Wang and Xiaomeng Li and Jiajia Li and Han Dong and Zhangjian Hu and Xiaojian Xia and Jingquan Yu and Yanhong Zhou}, doi = {10.1002/advs.202500110}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500110}, shortjournal = {Adv. Sci.}, title = {Manipulating the light systemic signal HY5 greatly improve fruit quality in tomato}, volume = {12}, year = {2025}, }
• (2025). A bio-responsive hydrogel with spatially heterogeneous structure for treating infectious tissue injuries. ADVS, 12(23), 2500088. (www)

  @article{ , abstract = {Infectious tissue injuries, exacerbated by bacterial infections and antibiotic resistance, pose significant challenges for treatment and may lead to life-threatening systemic infections. In this study, a bio-responsive hydrogel system is developed, leveraging silver ions (Ag⁺) encapsulated in Preyssler-type polyoxometalates (POMs). The Ag⁺ ions are selectively released in response to endogenous sodium ions (Na⁺) within the biological environment, enabling broad-spectrum antibacterial activity. The POM serves as a protective matrix for Ag⁺, preserving its bioactivity while mitigating cytotoxicity and the reduction in antimicrobial efficacy associated with prolonged exposure. Additionally, a dual-channel technique is employed to fabricate fiber membranes with controllable and continuously stacked chemical compositions, ensuring efficient and uniform POM incorporation via hydrogen bonding within the fiber matrix. Subsequently, in situ hierarchical cross-linking process generated a spatially heterogeneous hydrogel with an interpenetrating network structure at multiple scales. This differentiated microstructure facilitates the controlled loading and release of diverse therapeutic components. Meanwhile, bioactive exosomes are integrated into the hydrogel, further enhancing its regenerative potential for treating infectious tissue injuries. In vitro and in vivo experiments demonstrated that the advanced hydrogel system provide a viable and efficient platform for addressing the challenges associated with infectious tissue injuries, offering a promising strategy for clinical applications.}, archive = {J_ADVS}, author = {Zongtai Li and Tao Yang and Xiaolei Li and Panchao Yin and Bo Yang and Dongying Li and Yan Wang and Wei Teng and Qianqian Yu and Weichang Li}, doi = {10.1002/advs.202500088}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500088}, shortjournal = {Adv. Sci.}, title = {A bio-responsive hydrogel with spatially heterogeneous structure for treating infectious tissue injuries}, volume = {12}, year = {2025}, }
• (2025). Plasmon enhanced universal SERS detection of hierarchical plastics by 3D plasmonic funnel metastructure. ADVS, 12(23), 2500062. (www)

  @article{ , abstract = {Plasmonic nanostructures have aroused tremendous excitement in extreme light matter interactions because of efficient light harvesting and nanometer field concentration, ideal for solar thermal conversion, photocatalysis, photodetection, etc. Here a 3D self-assembled plasmonic nanostructure is reported for ultrasensitive SERS detection of hierarchical micro-nano plastic pollutants ranging from 30 nm to microns by rationally integrating high density of both surface and volumetric hot spots into one structure, enabled by V-shaped close-packed bi-metallic nanoparticles with massive nanovoids across transverse and longitudinal areas. The unique bi-metallic structure of hollow nanocones can enable an enhancement factor up to 1.1 × 10 8 as well as self-built enrichment of targeting hierarchical analytes toward the size-matched hot spot areas, resulting in not only race detection of micro-nano plastics with concentration down to 10 −8 g L −1 but also universal adaptability to simultaneous detection of a broad range of pollutants beyond micro-nano plastics. The results offer a practical solution for trace detection of hierarchical micro-nano plastics and other mixed aqueous pollutants, demonstrating considerable potential for combating water pollution.}, archive = {J_ADVS}, author = {Weixi Lu and Jian Luo and Yuyang Zhuang and Jie Liang and Min Xiong and Hui Liu and Lin Zhou}, doi = {10.1002/advs.202500062}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500062}, shortjournal = {Adv. Sci.}, title = {Plasmon enhanced universal SERS detection of hierarchical plastics by 3D plasmonic funnel metastructure}, volume = {12}, year = {2025}, }
• (2025). Electrically tunable momentum space polarization singularities in liquid crystal microcavities. ADVS, 12(23), 2500060. (www)

  @article{ , abstract = {Momentum space polarization singularities of light appear as vectorial twists in the scattered and radiated far field patterns of exotic photonic structures. They relate to important concepts such as bound states in the continuum, spatiotemporal light steering, polarization Möbius strips, Berry curvature, and associated topological photonic phenomena. Polarization singularities, such as completely circularly polarized C-points, are readily designed in real space through interference of differently polarized beams. In momentum space, they require instead sophisticated patterning of photonic crystal slabs of reduced symmetries in order to appear in the corresponding band structure with scarce in situ tunability. Here, it is shown that momentum space singularities can be generated and, importantly, electrically tuned in the band structure of a highly birefringent planar liquid crystal microcavity that retains many symmetries. The results agree with theoretical predictions and offer exciting possibilities for integration of momentum space polarization singularities in spinoptronic technologies.}, archive = {J_ADVS}, author = {Przemysław Oliwa and Piotr Kapuściński and Maria Popławska and Marcin Muszyński and Mateusz Król and Przemysław Morawiak and Rafał Mazur and Wiktor Piecek and Przemysław Kula and Witold Bardyszewski and Barbara Piętka and Helgi Sigurðsson and Jacek Szczytko}, doi = {10.1002/advs.202500060}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500060}, shortjournal = {Adv. Sci.}, title = {Electrically tunable momentum space polarization singularities in liquid crystal microcavities}, volume = {12}, year = {2025}, }
• (2025). Ternary inclusion co-crystals for efficient photothermal conversion and solar-driven water evaporation. ADVS, 12(23), 2500050. (www)

  @article{ , abstract = {Organic co-crystal engineering offers a convenient and efficient platform for preparing photothermal conversion (PTC) materials. However, current donor–acceptor (D–A) co-crystals generally have medium photothermal performance. Here, an inclusion co-crystal strategy is presented, i.e., host–guest encapsulation of small acceptor inside donor-type macrocycle's cavity, to enhance PTC efficiency through the promotion of D–A binding. A naphthyl-sidewall Tröger's base (TB[2]) molecular box donor is elaborately designed, which can encapsulate electron-deficient 7,7,8,8-tetracyanoquinodimethane (TCNQ) to form a 1:2 ternary inclusion charge-transfer (CT) co-crystal via the synergism of multiple noncovalent forces. Under 808 nm laser irradiation (0.7 W cm −2 ), the PTC efficiency of co-crystals is as high as 94.3%. The co-crystals are further introduced into the porous polymer of polyurethane (PU) to prepare an interfacial evaporator (TB-TCNQ@PU) for solar-driven water evaporation. Under 1 Sun irradiation, a high-water evaporation rate of 1.746 kg m −2 h −1 and a prominent solar-to-vapor efficiency of 93.8% are achieved. This work opens new avenues for the efficient PTC materials.}, archive = {J_ADVS}, author = {Ruotong Wang and Yi Su and Zhiyu Xiao and Tongtong Wang and Kun Liu and Zhihao Gong and Jiabin Wu and Junyi Chen and Zhixue Liu and Jingjing Li and Yu-Hui Zhang and Lu Wang and Bin Li and Xiaotao Zhang and Chunju Li}, doi = {10.1002/advs.202500050}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500050}, shortjournal = {Adv. Sci.}, title = {Ternary inclusion co-crystals for efficient photothermal conversion and solar-driven water evaporation}, volume = {12}, year = {2025}, }
• (2025). PABPN1 couples the polyadenylation and translation of maternal transcripts to mouse oocyte meiotic maturation. ADVS, 12(23), 2500048. (www)

  @article{ , abstract = {During oocyte meiosis, maternal transcript polyadenylation is crucial for regulating mRNA stability and translation, which are essential for oocyte maturation. Polyadenylate-binding protein nuclear 1 (PABPN1) plays a key role in regulating mRNA splicing and polyadenylation in somatic cells and growing oocytes. However, its potential function in regulating the meiotic maturation of fully grown oocytes remains unknown. This study reports that selective Pabpn1 knockout in growing mouse oocytes using Zp3-Cre do not affect folliculogenesis but prevented germinal vesicle breakdown in fully grown oocytes, impaired CDK1 activation, and resulted in abnormal spindle formation and chromosome misalignment. The results of poly(A)-inclusive full-length RNA isoform sequencing (PAIso-seq) and transcriptome sequencing revealed that PABPN1 coordinates meiotic maturation-coupled polyadenylation and degradation of maternal mRNAs, which are key factors of maturation-promoting factor (MPF) and deadenylation mediators, such as B-cell translocation gene-4 (BTG4), ensuring proper meiotic progression. The results of rescue experiments indicate these functions of PABPN1 are mediated by its key domains, which interact with poly(A) polymerase and recruit target mRNAs. This study highlighted the physiological importance of cytoplasmic PABPN1 in mammalian oocyte maturation by integrating maternal transcript polyadenylation, translation, and degradation.}, archive = {J_ADVS}, author = {Xing-Xing Dai and Yu-Ke Wu and Shuai-Bo Pi and Feng-Jie Hu and Yun-Wen Wu and Hang Qi and Zhiyi Li and Zhi-Yan Jiang and Long-Wen Zhao and Heng-Yu Fan}, doi = {10.1002/advs.202500048}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500048}, shortjournal = {Adv. Sci.}, title = {PABPN1 couples the polyadenylation and translation of maternal transcripts to mouse oocyte meiotic maturation}, volume = {12}, year = {2025}, }
• (2025). Fish swim bladder-derived ECM hydrogels effectively treat myocardial ischemic injury through immunomodulation and angiogenesis. ADVS, 12(23), 2500036. (www)

  @article{ , abstract = {Injectable hydrogel implants represent a promising therapeutic approach for ischemic heart failure; but their efficacy is often limited by low bioactivity, poor durability, and inadequate injection techniques. Herein, a unique hydrogel incorporating extracellular matrix from fish swim bladder (FSB-ECM), which has distinct advantages over mammalian derived ECM, such as low antigenicity, bioactivity, and source safety, is developed. It consists of collagen, glycoproteins, and proteoglycans, including 13 proteins common in the myocardial matrix and three specific proteins: HSPG, Col12a1, and vWF. This hydrogel enhances cardiac cell adhesion and stretching while promoting angiogenesis and M2 macrophage polarization. In addition, its storage modulus ( G ′) increases over time, reaching about 1000 Pa after 5 min, which facilitates transcatheter delivery and in situ gelling. Furthermore, this hydrogel provides sustained support for cardiac contractions, exhibiting superior longevity. In a rat model of ischemic heart failure, the ejection fraction significantly improves with FSB-ECM treatment, accompanied by increased angiogenesis, reduced inflammation, and decreased infarct size. Finally, RNA sequencing combined with in vitro assays identifies ANGPTL4 as a key protein involved in mediating the effects of FSB-ECM treatment. Overall, this new injectable hydrogel based on FSB-ECM is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure.}, archive = {J_ADVS}, author = {Yulong Fu and Canran Gao and Hailing Zhang and Jing Liu and Boxuan Li and Wei Chen and Xiuping Chen and Xue Lin and Ligang Fang and Zhihong Wang}, doi = {10.1002/advs.202500036}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500036}, shortjournal = {Adv. Sci.}, title = {Fish swim bladder-derived ECM hydrogels effectively treat myocardial ischemic injury through immunomodulation and angiogenesis}, volume = {12}, year = {2025}, }
• (2025). Flexocatalytic hydrogen generation and organics degradation by nano SrTiO3. ADVS, 12(23), 2500034. (www)

  @article{ , abstract = {Flexocatalysis, a groundbreaking approach in mechanocatalysis, overcomes the material limitations imposed by the symmetry requirements of piezocatalysis, enabling a broader range of materials to generate free radicals through mechano-catalytic reactions. This method not only offers an eco-friendly pathway for green hydrogen production via water splitting but also facilitates the use of biocompatible materials in health diagnostics and treatments. In this study, the flexocatalytic activity of centrosymmetric SrTiO 3 (STO) nanopowders is demonstrated, achieving notable hydrogen evolution (1289.53 µmol g −1 h −1 in pure water) and efficient organic dye degradation (≈94%). The mechanism is driven by electric polarization generated under non-uniform strain, which is strongly enhanced with particle size reduction, effectively linking flexoelectricity to superior electrochemical performance. The findings highlight the potential of flexocatalysis to revolutionize hydrogen production and broaden the range of materials for catalytic applications, paving the way for innovative energy-harvesting technologies.}, archive = {J_ADVS}, author = {Susmita Mondal and Rajib Chandra Das and Yumeng Du and Zhenyuan Hou and Konstantin Konstantinov and Zhenxiang Cheng}, doi = {10.1002/advs.202500034}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500034}, shortjournal = {Adv. Sci.}, title = {Flexocatalytic hydrogen generation and organics degradation by nano SrTiO3}, volume = {12}, year = {2025}, }
• (2025). KK2DP7 stimulates CD11b+ cell populations in the spleen to elicit trained immunity for anti-tumor therapy. ADVS, 12(23), 2500032. (www)

  @article{ , abstract = {The induction of trained immunity for anti-tumor therapy represents an emerging frontier in immunotherapy research, though its mechanistic underpinnings remain poorly understood. Adjuvant-induced trained innate immune responses constitute a critical yet underexplored component of adjuvant mechanisms of action. Here, KK2DP7, a dendrimer-structured peptide derived from the immunomodulatory antimicrobial peptide DP7 (VQWRIRVAVIRK) is employed, as a model adjuvant to establish standardized protocols for investigating adjuvant efficacy and mechanisms in enhancing anti-tumor immunity via trained immunity. Initial studies revealed that KK2DP7 administration significantly delayed tumor growth post-inoculation in murine models. The comprehensive analysis demonstrated that splenic cells exhibited cardinal features of trained immunity, whereas splenectomized mice exhibited complete loss of this protective effect. Strikingly, the adoptive transfer of CD11b + cells isolated from the non-lymphoid splenic compartment of KK2DP7-trained mice to naïve recipients conferred robust tumor suppression. Mechanistic investigations linked this phenomenon to TLR2-IRF7 axis activation and epigenetic reprogramming of CD11b + cells, as evidenced by chromatin accessibility assays and histone modification profiling. These findings not only unveil a novel therapeutically actionable dimension of trained immunity, centered on spleen-resident CD11b + cell reprogramming but also establish a standardized protocol framework for systematically investigating adjuvant mechanisms in the context of trained innate immunity.}, archive = {J_ADVS}, author = {Rui Zhang and Lin Tang and Yusi Wang and Xuejing Zhou and Zhenyu Ding and Li Yang}, doi = {10.1002/advs.202500032}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500032}, shortjournal = {Adv. Sci.}, title = {KK2DP7 stimulates CD11b+ cell populations in the spleen to elicit trained immunity for anti-tumor therapy}, volume = {12}, year = {2025}, }
• (2025). Solution-processable van der waals heterojunctions on silicon for self-powered photodetectors with high responsivity and detectivity. ADVS, 12(23), 2500027. (www)

  @article{ , abstract = {The high density of surface states on silicon has long impeded the development of high-performance photodetectors, leading to excessive dark leakage currents that adversely affect responsivity and detectivity. Herein, an all-solution-processable method is presented for fabricating photodetectors through consecutive spray-coating of a conductive metal-organic framework (MOF, Cu 3 (HHTP) 2 ) and metallic Ti 3 C 2 MXene to form van der Waals dual junctions on a silicon substrate. The heterojunction configuration facilitates unidirectional electron-hole separation within the Cu 3 (HHTP) 2 /Si interface with type I band alignment, while leveraging the potential barrier difference between the Cu 3 (HHTP) 2 /Si and Ti 3 C 2 /Cu 3 (HHTP) 2 Schottky junctions. The Ti 3 C 2 /Cu 3 (HHTP) 2 /Si photodetector demonstrates outstanding photoelectric performance, operating in a self-powered mode with a high specific detectivity of 1.63 × 10 12 Jones and a large responsivity of 1.8 A W −1 under 365 nm illumination. It also exhibits an impressive on/off ratio exceeding 3.9 × 10 4 at an incident light power density of 330 µW cm −2 . Additionally, the photodetector maintains excellent responsivity across a broad wavelength range from 365 to 700 nm, spanning ultraviolet to visible light, and sets a new performance benchmark for MOF-based photodetectors. This work introduces a straightforward, controllable approach for constructing high-quality van der Waals junctions on semiconductor surfaces, enabling the fabrication of optoelectronic devices with enhanced performance.}, archive = {J_ADVS}, author = {Yuansheng Ge and Da Lei and Chaojun Zhang and Quan Zhang and Jinlong Mu and Jing Li}, doi = {10.1002/advs.202500027}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500027}, shortjournal = {Adv. Sci.}, title = {Solution-processable van der waals heterojunctions on silicon for self-powered photodetectors with high responsivity and detectivity}, volume = {12}, year = {2025}, }
• (2025). Communications among neurocytes in parkinson's disease regulated by differential metabolism and blood-brain barrier traversing of chiral gold cluster-MOF integrated nanoparticles. ADVS, 12(23), 2500026. (www)

  @article{ , abstract = {This study have previously reported that ZIF-based chiral nanomedicines achieve Parkinson's disease (PD) therapy through differential metabolism and relief of neuroinflammation. However, lack of overall chirality and anti-inflammatory capacity of nanomedicines limit the further effective solution to the nanobiological effects research in PD. Here, it dexterously loaded chiral gold nanoclusters (AuNCs) onto the inner and outer surfaces of ZIF to achieve the purpose of simultaneously improving the overall chirality and anti-inflammatory activity of the composite nanoparticles (NPs). There are significant differences in the composition of protein corona between different chiral NPs, which elucidates the mechanism of chiral-mediated discrepancies in metabolism and the blood-brain barrier (BBB) traversing. Multi-omics and biochemical techniques further reveal that chiral NPs interfere with the chemokine axis (CX3CL1/CX3CR1)-NF-κB-NLRP3 and PI3K-AKT signaling pathways, regulate communications between neurons, neural stem cells and microglia (“the three-body problem”), and induce anti-inflammatory efficacy of microglia mitochondrial energy metabolic reprogramming in PD. The research uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral NPs, providing deep insights into the nanobiological effects of chiral anti-inflammatory nanomedicines in PD therapy for future clinical transformation.}, archive = {J_ADVS}, author = {Junyang Chen and Gaoxiang Xu and Runpu Shen and Jianzhong Xu and Congcong Lu and Xin Li and Qi Feng and Qing Li}, doi = {10.1002/advs.202500026}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500026}, shortjournal = {Adv. Sci.}, title = {Communications among neurocytes in parkinson's disease regulated by differential metabolism and blood-brain barrier traversing of chiral gold cluster-MOF integrated nanoparticles}, volume = {12}, year = {2025}, }
• (2025). Enhancing the protein stability of an anticancer VHH-fc heavy chain antibody through computational modeling and variant design. ADVS, 12(23), 2500004. (www)

  @article{ , abstract = {VHHs (also known as nanobodies) are important therapeutic antibodies. To prolong their half-life in bloodstream, VHHs are usually fused to the Fc fragment of full-length antibodies. However, stability is often the main challenge for their commercialization, and methods to improve stability are still lacking. Here, an in silico pipeline is developed for analyzing the stability of an anticancer VHH-Fc fusion antibody (VFA01) and designing its stable variants. Computational modeling is used to analyze the VFA01 structure and evaluate its conformational stability, disulfide bond reduction state, and aggregation and degradation tendency. By building mechanistic models of aggregation and degradation, the hotspot residues affecting stability: C130, F57, Y106, L120, and W111 are identified. Based on them, a series of VFA01 variants are designed and obtained a variant M11 (C130S/W111F/F57K) whose stability is significantly enhanced compared to VFA01: there are no visible particles in solution, and the change rate of DLS average hydrodynamic size, SEC HMW%, and CE-SDS purity are improved by 6.2-, 3.4-, and 1.5-fold, respectively. Both antigen-binding activity and production yield are also improved by about 1.5-fold. The results show that our computational pipeline is a very promising approach for improving the protein stability of therapeutic VHH-Fc fusion antibodies.}, archive = {J_ADVS}, author = {Yuan Fang and Menghua Song and Tianning Pu and Xiaoqing Song and Kailu Xu and Pengcheng Shen and Ting Cao and Yiman Zhao and Simon Hsu and Dongmei Han and Qiang Huang}, doi = {10.1002/advs.202500004}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2500004}, shortjournal = {Adv. Sci.}, title = {Enhancing the protein stability of an anticancer VHH-fc heavy chain antibody through computational modeling and variant design}, volume = {12}, year = {2025}, }
• (2025). Synergistic machine learning guided discovery of ABa3(BSe3)2X (A = rb, cs; x = cl, br, i): A promising family as property-balanced IR functional materials. ADVS, 12(23), 2417851. (www)

  @article{ , abstract = {Discovering novel infrared functional materials (IRFMs) hold tremendous significance for laser industry. Incorporating artificial intelligence into material discovery has been recognized as a pivotal trend driving advancements in materials science. In this work, an IRFM predictor based on machine learning (ML) is developed for the pre-selection of the most promising candidates, in which interpretable analyses reveal the prior domain knowledge of IRFMs. Under the guidance of this IRFM predictor, a series of selenoborates, ABa 3 (BSe 3 ) 2 X (A = Rb, Cs; X = Cl, Br, I) are successfully predicted and synthesized. Comprehensive characterizations together with first-principles analyses reveal that these materials exhibit preferred properties of wide bandgaps (2.92 – 3.04 eV), moderate birefringence (0.145 – 0.170 at 1064 nm), high laser-induced damage thresholds (LIDTs) (4 – 6 Ý AGS) and large second harmonic generation (SHG) responses (0.9 – 1 × AGS). Structure-property relationship analyses indicate that the [BSe 3 ] unit can be regarded as a potential gene for exploring novel IRFMs. This work may open an avenue for exploring high-performance materials.}, archive = {J_ADVS}, author = {Yihan Yun and Mengfan Wu and Zhihua Yang and Guangmao Li and Shilie Pan}, doi = {10.1002/advs.202417851}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417851}, shortjournal = {Adv. Sci.}, title = {Synergistic machine learning guided discovery of ABa3(BSe3)2X (A = rb, cs; x = cl, br, i): A promising family as property-balanced IR functional materials}, volume = {12}, year = {2025}, }
• (2025). Distinct CTC specific RNA profile enables NSCLC early detection and dynamic monitoring of advanced NSCLC. ADVS, 12(23), 2417849. (www)

  @article{ , abstract = {Circulating tumor cells (CTCs) hold significant potential as biomarkers for the diagnosis and management of non-small cell lung cancer (NSCLC). However, their clinical utility is limited by the heterogeneity of CTC subtypes and the need for robust, quantitative assays. In this study, a quantitative CTC RNA assay incorporating multi-antibody-based CTC isolation and specific mRNA quantification by RT-ddPCR is developed. Two distinct models are established: NSCLC CTC Score D for detecting early NSCLC (stages I-II), and NSCLC CTC Score M for monitoring advanced NSCLC (stages III-IV), based on distinct cohort criteria. NSCLC CTC Score D demonstrates high diagnostic performance for early-stage NSCLC, achieving an area under the receiver operating characteristic curve (AUC) of 0.93, significantly outperforming serum CEA (AUC = 0.70). Compared to NSCLC CTC Score D , NSCLC CTC Score M captures a key gene feature of KRT19 , whose fragment protein, serum CYFRA 21-1, is used as a prognostic biomarker for advanced NSCLC. Notably, CTC Scores M exhibits a more accurate early warning of patient responses to different therapies than serum CYFRA21-1 levels, which may provide a potential blood test-based biomarker for improved treatment assessment in advanced NSCLC.}, archive = {J_ADVS}, author = {Xiaoyu Wang and Pi Ding and Wenjuan Xu and Lei Qiu and Jing Ren and Yucheng Fei and Zhili Wang and Cheng Li and Yufei Xing and Mingjing Shen and Yawen Zhu and Yun Guo and Na Sun and Renjun Pei and Minhua Shi}, doi = {10.1002/advs.202417849}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417849}, shortjournal = {Adv. Sci.}, title = {Distinct CTC specific RNA profile enables NSCLC early detection and dynamic monitoring of advanced NSCLC}, volume = {12}, year = {2025}, }
• (2025). Radio-activated selenium-doped janus Ag/Ag2SexSy nanoparticles for precise cancer NIR-II fluorescence imaging and radiosensitization therapy. ADVS, 12(23), 2417828. (www)

  @article{ , abstract = {The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind of selenium-doped Ag/Ag 2 S Janus nanoparticles (Ag/Ag 2 Se x S y JNPs) is presented as radio-responsive molecular probes for precise tumor imaging and enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction nanoparticles with tunable doping ratios are synthesized, optimizing X-ray absorption and energy storage properties. Upon X-ray irradiation, the Ag/Ag 2 Se x S y JNPs interact with overexpressed hydrogen peroxide (H 2 O 2 ) in tumor cells, generating highly toxic hydroxyl radicals (·OH), which effectively induce tumor cell apoptosis. Additionally, Selenium incorporation improves electron–hole pair separation efficiency and enhances the photocurrent response, promoting increased electron transfer and ·OH generation, thus amplifying reactive oxygen species (ROS) production and enhancing radiosensitization. Furthermore, the fluorescence “OFF-ON” mechanism, triggered by H 2 O 2 -induced etching of silver allows real-time monitoring of H 2 O 2 levels via the second near-infrared window (NIR-II) fluorescence (FL) imaging “Turn On”, which delineates tumor boundaries for precise RT and reduce side effects to normal tissue. This dual-functional platform not only enables real-time tracking but also enhances therapeutic outcomes, offering a promising approach to precision cancer treatment.}, archive = {J_ADVS}, author = {Kang Zhu and Zhanyuan Li and Jingjing Cao and Yixi Cao and Jimei Wang and Shiyu Wang and Ling Chen and Huiqin Zhou and Wei Huang and Hanxun Zou and Qunsheng Li and Jing Mu and Jibin Song}, doi = {10.1002/advs.202417828}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417828}, shortjournal = {Adv. Sci.}, title = {Radio-activated selenium-doped janus Ag/Ag2SexSy nanoparticles for precise cancer NIR-II fluorescence imaging and radiosensitization therapy}, volume = {12}, year = {2025}, }
• (2025). Machine learning approach to characterize ferromagnetic La0.7Sr0.3MnO3 thin films via featurization of surface morphology. ADVS, 12(23), 2417811. (www)

  @article{ , abstract = {Ferromagnetic perovskite oxides, particularly La 0.7​ Sr 0.3 MnO 3 (LSMO), show significant promise for spintronics and electromagnetic applications due to their unique half-metallicity and colossal magnetoresistance properties. These properties are known to arise from Mn-O-Mn double-exchange interactions, which are directly related to microscopic lattice structures. However, since the microscopic structure in LSMO is highly sensitive to various material parameters, such as thickness, lattice strain, oxygen deficiency, and cation stoichiometry, understanding the intricate relationship between the microscopic structures and the resulting physical properties of LSMO remains challenging. Herein, a machine learning approach is introduced to characterize ferromagnetic LSMO thin films by featurization of their surface morphology. Using an ensemble machine learning method, the non-linear correlations between surface morphology and the electronic, magnetic properties of LSMO thin films are captured and modeled. Based on these estimated correlations, LSMO thin films are classified into five representative types, each characterized by distinctive properties and surface morphologies. These results imply that surface morphology can reveal hidden information about the strongly correlated properties of ferromagnetic LSMO thin films. Consequently, the machine learning-based approach provides an efficient method for understanding the correlated material properties of ferromagnetic oxides and related materials through surface morphology analysis.}, archive = {J_ADVS}, author = {Sanghyeok Ryou and Jihyun Lim and Minwoo Jang and Kitae Eom and Sunwoo Lee and Hyungwoo Lee}, doi = {10.1002/advs.202417811}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417811}, shortjournal = {Adv. Sci.}, title = {Machine learning approach to characterize ferromagnetic La0.7Sr0.3MnO3 thin films via featurization of surface morphology}, volume = {12}, year = {2025}, }
• (2025). Orbital coupling and spin textures of Fe/Pd thin films grown on si substrate with high magnetic fields. ADVS, 12(23), 2417810. (www)

  @article{ , abstract = {The crystallization and magnetic properties strongly depend on the orbital coupling and spin polarization of magnetic materials. Here, the enhancement and freeze of coupling and polarization of atomic orbitals achieved by high magnetic fields are delineated through the first-principles calculations. Thus a growth method (under high magnetic fields) is proposed to design the crystallization and magnetic structure of the Fe/Pd thin films. The dynamic processes of film growth are revealed based on the observation of transmission electron microscopy. As the magnetic field increased, the Fe film is found to develop from a unique droplet shape to a 2D growth mode, which is caused by the competition between demagnetization energy and interfacial energy. Furthermore, the improvements achieved by high magnetic fields in macroscopic magnetic properties and ordered magnetic domains are demonstrated, confirming the effective regulation of the orbital coupling and spin textures from this designed method. This work provides a new perspective for understanding the interaction between atomic-orbital and external magnetic fields and offers a strategy for the preparation of high-performance magnetoelectric and spintronic devices.}, archive = {J_ADVS}, author = {Xuefeng Wu and Bin Gong and Wenyu Kang and Li Chen and Xu Li and Yaping Wu and Junyong Kang}, doi = {10.1002/advs.202417810}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417810}, shortjournal = {Adv. Sci.}, title = {Orbital coupling and spin textures of Fe/Pd thin films grown on si substrate with high magnetic fields}, volume = {12}, year = {2025}, }
• (2025). Microneedle patch for in situ neutrophil monitoring. ADVS, 12(23), 2417801. (www)

  @article{ , abstract = {Monitoring neutrophil levels plays an essential role in diagnosing infections and various diseases, as well as for managing specific treatments such as chemotherapy and radiotherapy. However, the traditional complete blood count technique is invasive and challenging for quick and frequent monitoring of neutrophil. Herein, a button-like microneedle patch for rapid and convenient detection of neutrophil levels is reported without vascular invasion. This patch consists of a hollow microneedle array with a vacuum chamber for extraction of interstitial fluid, a hydrogel sheet for colorimetric detection of neutrophil level based on neutrophil-specific enzyme (myeloperoxidase), and a mobile phone application for data recording and quantification. The detection ability is validated both in vitro and in vivo in a chemotherapy-induced neutropenic rat model. Moreover, this button patch achieves precise measurement of the neutrophil levels in patients’ urine and abdominal drainage fluid. This minimally invasive colorimetric patch can potentiate in situ neutrophil monitoring without blood sampling procedures or in-lab apparatus, which can serve as a substitution for routine blood counts especially for patients in less developed areas.}, archive = {J_ADVS}, author = {Ziyi Lu and Ruisi Cai and Tianao Xie and Sheng Zhao and Sarun Juengpanich and Win Topatana and Shijie Li and Jiasheng Cao and Jiahao Hu and Tianen Chen and Jiachen Chen and Jicheng Yu and Tao Sheng and Wentao Zhang and Hao Wang and Jiahuan You and Yukai Shan and Yuchao Sun and Ruijing Shen and Zhengjie Zhao and Kangfan Ji and Ziqi Gao and Xinmin Yu and Xiujun Cai and Zhen Gu and Yuqi Zhang and Mingyu Chen}, doi = {10.1002/advs.202417801}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417801}, shortjournal = {Adv. Sci.}, title = {Microneedle patch for in situ neutrophil monitoring}, volume = {12}, year = {2025}, }
• (2025). Elastic deformation of Cellulose/Lignin-based anode for rejuvenating aged mix-cultured electroactive biofilms. ADVS, 12(23), 2417788. (www)

  @article{ , abstract = {Electroactive biofilms (EABs) are essential components of both natural and artificial bio-electrochemical systems (BESs). However, the inevitable decay of EABs during prolonged operation can diminish their performance. In this contribution, an effective and noninvasive strategy for rejuvenating aging biofilms by the elastic deformation of anode material is approved. The synthesized wood tracheid-like structures anode material showed excellent compressibility and fatigue resistance in a wet state. The findings indicate that after the elastic deformation of the anode, aged biofilm exhibited a 37.5% increase in metabolic activity, and multi-SIM images confirmed the removal of dead cells. Analysis of the extruded substance revealed a significant removal of loosely bound extracellular polymeric substance which doesn't contribute directly to electron transfer. Community analysis demonstrated the rejuvenation process suppressed the ecological competition from non-exoelectrogens. Overall, there is a notable 25.97% increase in power density following the elastic deformation of the anode. Additionally, ion diffusion, specific capacitance, and catalytic response current all improved. To the knowledge, this is the first report employing an anode deformation strategy to restore decayed mix-cultured electroactive biofilm, which is vital for the practical long-term application of BESs. This work also offers new insights into the mechanical influence of anode materials on microorganisms.}, archive = {J_ADVS}, author = {Xue Liu and Zheng Zhang and Qingwen Zheng and Chengcheng Suo and Bailing Dong and Huiying Song and Jiayi Wang and Jia Liu and Runfeng Yuan and Sailike Milanbieke and Sha Luo and Chenhui Yang and Zhijun Chen and Ruiwen Wang and Wei Li and Shouxin Liu}, doi = {10.1002/advs.202417788}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417788}, shortjournal = {Adv. Sci.}, title = {Elastic deformation of Cellulose/Lignin-based anode for rejuvenating aged mix-cultured electroactive biofilms}, volume = {12}, year = {2025}, }
• (2025). Programmable metamaterials with perforated shell group supporting versatile information processing. ADVS, 12(23), 2417784. (www)

  @article{ , abstract = {Mechanical metamaterials have emerged as promising tools for enabling mechanical intelligence in soft machines through interaction with the external environment. Note that most representative results in the literature focused on certain features of information processing with the designs of novel metamaterials. It remains challenging to design metamaterials with more integrated information processing capabilities toward comprehensive intelligence. In this work, a novel approach employing programmable multi-stability of perforated shells (PS) with staggered trapezoidal voids is proposed to develop transformable, information-processing metamaterials with high-density information. Multi-layer information storage, encoding, decoding, and reading are achieved by designing and arranging different types of PSs under mechanical compression or magnetic actuation. In addition, various application-oriented functionalities, such as information encryption, mechanical computing, wave amplification, and pressure transmission, are also demonstrated by taking advantage of the stable memory and tunable stiffness distributions of metamaterials. The proposed design strategy paves the way for multifunctional, miniaturized, and scalable information mechanical metamaterials, with significant potential for soft-material-based intelligent devices.}, archive = {J_ADVS}, author = {Xiaoyuan Ma and Ziran Wang and Weipeng Zhang and Peng Yan}, doi = {10.1002/advs.202417784}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417784}, shortjournal = {Adv. Sci.}, title = {Programmable metamaterials with perforated shell group supporting versatile information processing}, volume = {12}, year = {2025}, }
• (2025). Pronounced role of lithium-controlling polymer in water-Processable/Halogen-free all-solid-state electrolytes for lithium supercapacitors. ADVS, 12(23), 2417745. (www)

  @article{ , abstract = {Polymeric solid-state electrolytes (SSEs) with environmentally friendly processes deliver safer and cleaner energy storage devices without fires and leakages than conventional liquid electrolytes. Here, water-processable halogen-free polymeric SSEs are demonstrated with high ion conductivity (≈6 mS cm −1 ), prepared from aqueous solutions consisting of branched poly(ethylene imine) (bPEI), lithium hydroxide (LiOH), and poly(4-styrene sulfonic acid) (PSSA). The bPEI:LiOH:PSSA (PLP) SSEs with various PSSA molar ratios are applied to asymmetric supercapacitors with graphite-based anodes and indium tin oxide (ITO) counter electrodes. The PSSA molar ratio strongly affected the ion conductivity of PLP SSEs, leading to a maximum at PSSA = 40 mol%, owing to the role of PSSA in controlling the size of LiOH domains for better Li + transport pathways. The enhanced ion conductivity enabled PLP-supercapacitors to build a high potential of 2.24 V at PSSA = 40 mol%, compared to 1.64 V at 0 mol%, upon galvanostatic charge/discharge at a current density of 0.2 mA g −1 . The endurance test shows that the supercapacitors with the PLP SSEs (PSSA = 40 mol%) can function stably with high capacitance retention (96.2%) for more than 5000 cycles, and ≈80% capacitance retention at 80 °C, supporting their practical use in high-safety supercapacitors and batteries.}, archive = {J_ADVS}, author = {Deepu Murukadas and Hwajeong Kim and Youngkyoo Kim}, doi = {10.1002/advs.202417745}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417745}, shortjournal = {Adv. Sci.}, title = {Pronounced role of lithium-controlling polymer in water-Processable/Halogen-free all-solid-state electrolytes for lithium supercapacitors}, volume = {12}, year = {2025}, }
• (2025). OcuPair, a novel photo-crosslinkable PAMAM dendrimer-hyaluronic acid hydrogel Bandage/Bioadhesive for corneal injuries and temporary corneal repair. ADVS, 12(23), 2417731. (www)

  @article{ , abstract = {Traumatic corneal injuries are a leading cause of blindness among military personnel. These injuries need immediate attention in the combat zone, but treatment options are limited as life-saving measures are often prioritized. To address this critical gap, we have developed OcuPair TM , a two-component hydrogel system that consists of i) an injectable viscoelastic filler that stabilizes the ocular cavity and prevents hypotony. ii) An in situ photo-curable adhesive hydrogel comprising of methacrylated, hydroxyl PAMAM dendrimer and hyaluronic acid engineered to form a transparent, flexible, and robust bandage within 90 seconds, adhering to the corneal surface and ensuring a water-tight seal securing full-thickness corneal wounds. Ex vivo studies demonstrated that the adhesive hydrogel is mechanically robust and withstands intraocular pressures beyond physiological range. In a rabbit corneal injury model, OcuPair TM effectively sealed complex full-thickness wounds and preserved the eye with favorable clinical outcomes for 5 days with no toxicity over 30 days. In this study, we have validated the pilot scale synthesis, formulation optimization, GMP scale-up, and IDE-enabling GLP toxicity, essential for clinical translation as a battlefield-ready solution.}, archive = {J_ADVS}, author = {Siva P. Kambhampati and Rishi Sharma and Hui Lin and Santiago Appiani and Jeffrey L. Cleland and Samuel C. Yiu and Rangaramanujam M. Kannan}, doi = {10.1002/advs.202417731}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417731}, shortjournal = {Adv. Sci.}, title = {OcuPair, a novel photo-crosslinkable PAMAM dendrimer-hyaluronic acid hydrogel Bandage/Bioadhesive for corneal injuries and temporary corneal repair}, volume = {12}, year = {2025}, }
• (2025). LRRC4 deficiency drives premature ovarian insufficiency by disrupting metabolic homeostasis in granulosa cells. ADVS, 12(23), 2417717. (www)

  @article{ , abstract = {Premature ovarian insufficiency (POI), defined by early loss of ovarian activity before the age of 40 years, is the leading cause of infertility and systematic aging in women, posing a public health challenge worldwide. However, its molecular etiology and therapeutic options are still lacking. Here, leucine-rich repeat containing 4 (LRRC4) is identified as a critical regulator of folliculogenesis expressed in granulosa cells (GCs), which contributes to ovarian reserve maintenance. LRRC4 deficiency triggers defective oocyte maturation and excessive follicular atresia through inhibition of GC differentiation and ultimately leads to POI. Mechanistically, LRRC4 balances mitochondrial fission and fusion to inhibit excessive mitophagy by promoting the K48-linked ubiquitination degradation of Yes-associated protein (YAP), thereby maintaining the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis. Importantly, targeting LRRC4 normalized follicular development and ovarian function in POI model mice. In conclusion, these data reveal the novel pathogenesis of POI and suggest that LRRC4 is a potential target for the diagnosis and treatment of POI.}, archive = {J_ADVS}, author = {Yujie Shang and Yunjun Li and Di Han and Kun Deng and Wei Gao and Minghua Wu}, doi = {10.1002/advs.202417717}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417717}, shortjournal = {Adv. Sci.}, title = {LRRC4 deficiency drives premature ovarian insufficiency by disrupting metabolic homeostasis in granulosa cells}, volume = {12}, year = {2025}, }
• (2025). LncRNA-MEG3 regulates muscle mass and metabolic homeostasis by facilitating SUZ12 Liquid–Liquid phase separation. ADVS, 12(23), 2417715. (www)

  @article{ , abstract = {Skeletal muscle plays a crucial role in maintaining motor function and metabolic homeostasis, with its loss or atrophy leading to significant health consequences. Long non-coding RNAs (lncRNAs) have emerged as key regulators in muscle biology; however, their precise roles in muscle function and pathology remain to be fully elucidated. This study demonstrates that lncRNA maternally expressed gene 3 (MEG3) is preferentially expressed in slow-twitch muscle fibers and dynamically regulated during muscle development, aging, and in the context of Duchenne muscular dystrophy (DMD). Using both loss- and gain-of-function mice models, this study shows that lncRNA-MEG3 is critical for preserving muscle mass and function. Its depletion leads to muscle atrophy, mitochondrial dysfunction, and impaired regenerative capacity, while overexpression enhances muscle mass, increases oxidative muscle fiber content, and improves endurance. Notably, lncRNA-MEG3 overexpression in MDX mice significantly alleviates muscle wasting and adipose tissue infiltration. Mechanistically, this study uncovers a novel interaction between lncRNA-MEG3 and the polycomb repressive complex 2 (PRC2), where lncRNA-MEG3 binds to SUZ12 polycomb repressive complex 2 subunit (Suz12), stabilizes PRC2, facilitates SUZ12 liquid–liquid phase separation (LLPS), and regulates the epigenetic modulation of four and a half lim domains 3 (Fhl3) and ring finger protein 128 (Rnf128). These findings not only highlight the crucial role of lncRNA-MEG3 in muscle homeostasis but also provide new insights into lncRNA-based therapeutic strategies for muscle-related diseases.}, archive = {J_ADVS}, author = {Yilong Yao and Chao Yan and Haibo Huang and Shilong Wang and Jiaying Li and Yun Chen and Xiaolu Qu and Qi Bao and Lingna Xu and Yuanyuan Zhang and Danyang Fan and Xia He and Yanwen Liu and Yongsheng Zhang and Yalan Yang and Zhonglin Tang}, doi = {10.1002/advs.202417715}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417715}, shortjournal = {Adv. Sci.}, title = {LncRNA-MEG3 regulates muscle mass and metabolic homeostasis by facilitating SUZ12 Liquid–Liquid phase separation}, volume = {12}, year = {2025}, }
• (2025). Bioengineered tumor-derived extracellular vehicles suppressed colorectal cancer liver metastasis and bevacizumab resistance. ADVS, 12(23), 2417714. (www)

  @article{ , abstract = {Antiangiogenic therapies, such as bevacizumab, are among the causes of cancer-related death in patients with colorectal cancer (CRC) with liver metastasis. Delivering siRNAs via primary cell originating from primary cells is a promising method for targeting CRC liver metastasis and drug resistance. Here, it is found that the expression of CCL24 is significantly upregulated in tumor tissues at the CRC liver metastasis site. In addition, CCL24 is significantly upregulated in tumor tissues from bevacizumab-resistant patients. CCL24 promotes the formation of inflammatory tumor-associated fibroblast subsets in the CRC liver metastasis microenvironment and induces resistance to bevacizumab therapy. Based on these results, a primary cell-derived extracellular vehicle delivery system is designed for the simultaneous delivery of siRNAs targeting CCL24 in the tumor microenvironment (TME). Downregulation of CCL24 in the TME by delivering bioengineered extracellular vehicles significantly increased sensitivity to antiangiogenic therapy in a CRC mouse model. A novel therapeutic target is identified for patients with CRC with liver metastasis and suggested a possible therapeutic alternative for patients with CRC with resistance to antiangiogenic therapy and distant metastasis.}, archive = {J_ADVS}, author = {Junjiang Wang and Chunsheng Liu and Ping Wang and Zhiyuan Liu and Weixian Hu and Zejian Lv and Chengzhi Huang and Xueqing Yao}, doi = {10.1002/advs.202417714}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417714}, shortjournal = {Adv. Sci.}, title = {Bioengineered tumor-derived extracellular vehicles suppressed colorectal cancer liver metastasis and bevacizumab resistance}, volume = {12}, year = {2025}, }
• (2025). Engineered tissue models to decode Host–Microbiota interactions. ADVS, 12(23), 2417687. (www)

  @article{ , abstract = {A mutualistic co-evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but also contributing to the well-being of the whole organism through systemic communication with other distant niches (axis). Emerging evidence indicates that when the composition of the microbiota inhabiting the niche changes toward a pathogenic state (dysbiosis) and interactions with the host become unbalanced, diseases may present. In addition, imbalances within a single niche can cause dysbiosis in distant organs. Current research efforts are focused on elucidating the mechanisms leading to dysbiosis, with the goal of restoring tissue homeostasis. In vitro models can provide critical experimental platforms to address this need, by reproducing the niche cyto-architecture and physiology with high fidelity. This review surveys current in in vitro host–microbiota research strategies and provides a roadmap that can guide the field in further developing physiologically relevant in vitro models of ecological niches, thus enabling investigation of the role of the microbiota in human health and diseases. Lastly, given the Food and Drug Administration Modernization Act 2.0, this review highlights emerging in vitro strategies to support the development and validation of new therapies on the market.}, archive = {J_ADVS}, author = {Miryam Adelfio and Grace E. Callen and Xuesong He and Bruce J. Paster and Hatice Hasturk and Chiara E. Ghezzi}, doi = {10.1002/advs.202417687}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417687}, shortjournal = {Adv. Sci.}, title = {Engineered tissue models to decode Host–Microbiota interactions}, volume = {12}, year = {2025}, }
• (2025). A promising MM–Fe–Al–Ga–B permanent material with substantially boosted magnetic performance. ADVS, 12(23), 2417679. (www)

  @article{ , abstract = {Exploiting the potential of mischmetal (MM, La–Ce–Pr–Nd mixture containing ≈80 wt% La–Ce) based MM–Fe–B permanent material as an advantageous alternative for the current Nd–Fe–B is intriguing, whereas remains an arduous quest due to the drastically deteriorated magnetic performance. Herein, a facile two-step strategy is proposed that Al-doping towards high maximum energy product (BH) max with the subsequential grain boundary diffusion processing (GBDP) toward high coercivity H cj , i.e., a representative 0.7 wt% Al doping and Nd/Pr-based GBDP yields the record-high H cj = 10.14 kOe and (BH) max = 28.02 MGOe for the MM–Fe–Al–Ga–B sintered magnets. Appropriate Al-doping plays a pivotal role in accelerating the La/Ce segregation in the LaCe-rich RE–(Al, Ga), La-rich RE 6 (Fe, Al, Ga) 14 , and Ce-rich REFe 2 intergranular phases, resulting in enhanced intrinsic and extrinsic magnetism. The following Nd/Pr-based GBDP generates large quantities of RE 6 (Fe, Al, Ga) 14 phase in triple junctions and grain boundaries, together with continuous Nd/Pr-rich magnetically hardening shell, finally harvesting the substantially boosted magnetic performance. This demonstration marks a clear picture of the two-step strategy towards fully utilizing the abundant MM resources, and overcoming the long-standing difficulty of applicable MM–Fe–B permanent material for industrialization.}, archive = {J_ADVS}, author = {Wang Chen and Shaoqing Ren and Jiaying Jin and Liang Zhou and Bo Xin and Mingjing Zhao and Mengfan Bu and Xu Li and Chen Wu and Mi Yan}, doi = {10.1002/advs.202417679}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417679}, shortjournal = {Adv. Sci.}, title = {A promising MM–Fe–Al–Ga–B permanent material with substantially boosted magnetic performance}, volume = {12}, year = {2025}, }
• (2025). Disturbance-aware on-chip training with mitigation schemes for massively parallel computing in analog deep learning accelerator. ADVS, 12(23), 2417635. (www)

  @article{ , abstract = {On-chip training in analog in-memory computing (AIMC) holds great promise for reducing data latency and enabling user-specific learning. However, analog synaptic devices face significant challenges, particularly during parallel weight updates in crossbar arrays, where non-uniform programming and disturbances often arise. Despite their importance, the disturbances that occur during training are difficult to quantify based on a clear mechanism, and as a result, their impact on training performance remains underexplored. This work precisely identifies and quantifies the disturbance effects in 6T1C synaptic devices based on oxide semiconductors and capacitors, whose endurance and variation have been validated but encounter worsening disturbance effects with device scaling. By clarifying the disturbance mechanism, three simple operational schemes are proposed to mitigate these effects, with their efficacy validated through device array measurements. Furthermore, to evaluate learning feasibility in large-scale arrays, real-time disturbance-aware training simulations are conducted by mapping synaptic arrays to convolutional neural networks for the CIFAR-10 dataset. A software-equivalent accuracy is achieved even under intensified disturbances, using a cell capacitor size of 50fF, comparable to dynamic random-access memory. Combined with the inherent advantages of endurance and variation, this approach offers a practical solution for hardware-based deep learning based on the 6T1C synaptic array.}, archive = {J_ADVS}, author = {Jaehyeon Kang and Jongun Won and Narae Han and Sangjun Hong and Jee-Eun Yang and Sangwook Kim and Sangbum Kim}, doi = {10.1002/advs.202417635}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417635}, shortjournal = {Adv. Sci.}, title = {Disturbance-aware on-chip training with mitigation schemes for massively parallel computing in analog deep learning accelerator}, volume = {12}, year = {2025}, }
• (2025). SCORT–Cas13d nanotherapy precisely targets the ‘Undruggable’ transcription factor HoxB13 in metastatic prostate cancer in vivo. ADVS, 12(23), 2417605. (www)

  @article{ , abstract = {Metastatic cancer, the primary cause of cancer mortality, frequently exhibits heightened dependence on certain transcription factors (TFs), which serve as master regulators of oncogenic signaling yet are often untargetable by small molecules. Selective Cell in ORgan Targeting (SCORT) nanoparticles are developed for precise CRISPR/Cas13d mRNA and gRNA delivery to metastatic cancer cells in vivo, aiming to knock down the undruggable oncogenic TF HoxB13. In prostate cancer liver metastasis models driven by HoxB13, repeated systemic SCORT- Cas13d -g HoxB13 treatment significantly decreases HoxB13 expression, reduces metastasis, and extends mouse survival. Prolonged treatment shows no significant impact on major organ function, histology or immune markers. Mechanistically, SCORT- Cas13d -g HoxB13 treatment suppresses metastatic tumor proliferation and angiogenesis while promoting apoptosis by regulating multiple gene pathways. Unexpectedly, it inhibits the non-canonical, EMT-independent oncogenic function of Snail. These findings suggest that SCORT- Cas13d -g HoxB13 can effectively and safely target the undruggable HoxB13 in metastatic prostate cancer, positioning CRISPR/Cas13d as a potential treatment.}, archive = {J_ADVS}, author = {Zhifen Cui and Furong Huang and Kun Fang and Jingyue Yan and Yuebao Zhang and Diana D. Kang and Yufan Zhou and Yue Zhao and Jeffrey I. Everitt and William Hankey and Andrew J Armstrong and Jiaoti Huang and Hongyan Wang and Victor X. Jin and Yizhou Dong and Qianben Wang}, doi = {10.1002/advs.202417605}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417605}, shortjournal = {Adv. Sci.}, title = {SCORT–Cas13d nanotherapy precisely targets the ‘Undruggable’ transcription factor HoxB13 in metastatic prostate cancer in vivo}, volume = {12}, year = {2025}, }
• (2025). Leucine-rich repeat-containing g protein-coupled receptor 6 ameliorates pressure overload-induced cardiac hypertrophy by regulating cardiomyocyte metabolic reprogramming. ADVS, 12(23), 2417597. (www)

  @article{ , abstract = {Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine-rich repeat-containing G protein-coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular diseases. In this study, the potential of Lgr6 to counteract pressure overload (PO)-induced cardiac hypertrophy is investigated, and the underlying mechanisms involved are elucidated. Transverse aortic constriction (TAC) is induced to establish an in vivo cardiac hypertrophy model. Adeno-associated virus 9 and adenovirus vectors are utilized to knock down and overexpress Lgr6 in cardiomyocytes, respectively. The effects of Lgr6 and its downstream molecules are subsequently determined using RNA sequencing and chromatin immunoprecipitation. Significant downregulation of Lgr6 expression is observed in the heart after TAC and in cardiomyocytes treated with phenylephrine. Lgr6 deficiency accelerated and Lgr6 overexpression inhibits cardiac hypertrophy and dysfunction after TAC. Mechanistically, the in vivo and in vitro experiments suggest that Lgr6 regulates the expression of ubiquitin specific protease 4 (USP4) and peroxisome proliferator-activated receptor alpha (PPARα) by activating the cGMP/PKG/CREB1 signalling pathway, thereby regulating cardiomyocyte metabolic reprogramming after PO. Targeting Lgr6 can be a potential therapeutic strategy to treat pathological cardiac hypertrophy.}, archive = {J_ADVS}, author = {Mengmeng Zhao and Jianfang Liu and Shanshan Peng and Zihui Zheng and Siqi Liu and Jun Wan and Yao Xu and Menglong Wang}, doi = {10.1002/advs.202417597}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417597}, shortjournal = {Adv. Sci.}, title = {Leucine-rich repeat-containing g protein-coupled receptor 6 ameliorates pressure overload-induced cardiac hypertrophy by regulating cardiomyocyte metabolic reprogramming}, volume = {12}, year = {2025}, }
• (2025). Balancing h* Adsorption/Desorption by localized 4f orbital electrons of lanthanide dopants in carbon-encapsulated MoP for boosted hydrogen evolution. ADVS, 12(23), 2417583. (www)

  @article{ , abstract = {MoP is one of the most efficient catalysts for hydrogen evolution reaction (HER). However, molybdenum ion exhibits a strong adsorption ability for H * due to the abundant states in the conduction bands associated with the dispersed nature of Mo 4d electrons, which is difficult to change through interactions with other transition metal dopants of d orbital electrons. Herein, lanthanide (Ln: La, Ce, Sm, Gd, and Yb) dopants of localized 4f orbital are used to hybridize with d and p orbitals of MoP to balance the H * adsorption energy to significantly enhance the HER activity. Density functional theory calculations indicate that the localized 4f orbital of Ln extended 4d orbital electronic density states of Mo to modulate the electron configuration near the Fermi level. Among various Ln-doped MoP with carbon-encapsulated catalysts (Ln-MoP@C) catalysts, Gd-MoP@C containing Mo 4d, C 2p, P 3p, and Gd 4f and 5d orbitals form significant states at the Fermi level, leading to the high intrinsic HER activity with low overpotentials of 74 and 134 mV at 10 mA cm −2 in alkaline and acid electrolytes, respectively. This study provides a guiding principle for selecting dopants to tune electronic structures and enhance the intrinsic catalytic activities of transition metal catalysts through f-d-p orbital coupling.}, archive = {J_ADVS}, author = {Jiancheng Li and Juanli Zhao and Yanning Zhang and Yuchen Liu and Maoyuan Li and Riyue Ge and Wenxian Li and Bin Liu}, doi = {10.1002/advs.202417583}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417583}, shortjournal = {Adv. Sci.}, title = {Balancing h* Adsorption/Desorption by localized 4f orbital electrons of lanthanide dopants in carbon-encapsulated MoP for boosted hydrogen evolution}, volume = {12}, year = {2025}, }
• (2025). Unveiling salt tolerance mechanisms in plants: Integrating the KANMB machine learning model with metabolomic and transcriptomic analysis. ADVS, 12(23), 2417560. (www)

  @article{ , abstract = {Salt stress presents a substantial threat to cereal crop productivity, especially in coastal agricultural regions where salinity levels are high. Addressing this challenge requires innovative approaches to uncover genetic resources that support molecular breeding of salt-tolerant crops. In this study, a novel machine learning model, KANMB is introduced, designed to analyze integrated multi-omics data from the natural halophyte Spartina alterniflora under various NaCl concentrations. Using KANMB, 226 metabolic biomarkers significantly linked to salt stress responses, grounded in metabolomic and transcriptomic profiles are identified. These biomarkers correlate with metabolic pathways associated with salt tolerance, providing insight into the underlying biochemical mechanisms. A co-expression analysis further highlights the MYB gene SaMYB35 as a pivotal regulator in the flavonoid biosynthesis pathway under salt stress. When overexpressed SaMYB35 in rice (ZH11) grown under high salinity, it triggers the upregulation of key flavonoid biosynthetic genes, elevates flavonoid content, and enhances salt tolerance compared to wild-type plants. The findings from this study offer a valuable genetic toolkit for breeding salt-tolerant cereal varieties and demonstrate the power of machine learning in accelerating biomarker discovery for stress resilience in non-model plant species.}, archive = {J_ADVS}, author = {Shoukun Chen and Hao Zhang and Shuqiang Gao and Kunhui He and Tingxi Yu and Shang Gao and Jiankang Wang and Huihui Li}, doi = {10.1002/advs.202417560}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417560}, shortjournal = {Adv. Sci.}, title = {Unveiling salt tolerance mechanisms in plants: Integrating the KANMB machine learning model with metabolomic and transcriptomic analysis}, volume = {12}, year = {2025}, }
• (2025). Chromosome-level genome assembly of the leafcutter bee megachile rotundata reveals its ecological adaptation and pollination biology. ADVS, 12(23), 2417054. (www)

  @article{ , abstract = {The leafcutter bee Megachile rotundata is the world's most intensively managed solitary bee, owing to its easy manipulation and high pollination efficacy. Here, a high-quality chromosome-level M. rotundata genome, covering 280.68 Mb is presented. A total of 10 701 genes are predicted, of which 93.06% are functionally annotated. Based on the new genome assembly, transposable elements, noncoding RNAs, as well as gene families associated with pollination biology and ecological adaptation are systematically characterized. Comparative genomic analysis shows a notable expansion of Toll gene family but the contraction of detoxification gene in M. rotundata genome. Surprisingly, these expanded Toll-1 genes and their downstream genes display abundant mRNA levels in diapausing prepupae. Additionally, diapausing prepupae show significantly upregulated expression of antimicrobial peptide genes and a higher survival rate after Escherichia coli exposure compared to nondiapausing prepupae, indicating an enhanced immune response during M. rotundata diapause. The M. rotundata genome provides an important foundation for understanding its ecological adaptation and optimizing its exceptional pollination efficiency in the future.}, archive = {J_ADVS}, author = {Rangjun Shi and Pan Duan and Mengmeng Zhu and Rong Zhang and Zihua Zhao and Xin Nie and Hanhou He and Li Hou and Xianhui Wang}, doi = {10.1002/advs.202417054}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2417054}, shortjournal = {Adv. Sci.}, title = {Chromosome-level genome assembly of the leafcutter bee megachile rotundata reveals its ecological adaptation and pollination biology}, volume = {12}, year = {2025}, }
• (2025). DeepCCDS: Interpretable deep learning framework for predicting cancer cell drug sensitivity through characterizing cancer driver signals. ADVS, 12(23), 2416958. (www)

  @article{ , abstract = {Accurate characterization of cellular states is the foundation for precise prediction of drug sensitivity in cancer cell lines, which in turn is fundamental to realizing precision oncology. However, current deep learning approaches have limitations in characterizing cellular states. They rely solely on isolated genetic markers, overlooking the complex regulatory networks and cellular mechanisms that underlie drug responses. To address this limitation, this work proposes DeepCCDS, a Deep learning framework for Cancer Cell Drug Sensitivity prediction through Characterizing Cancer Driver Signals. DeepCCDS incorporates a prior knowledge network to characterize cancer driver signals, building upon the self-supervised neural network framework. The signals can reflect key mechanisms influencing cancer cell development and drug response, enhancing the model's predictive performance and interpretability. DeepCCDS has demonstrated superior performance in predicting drug sensitivity compared to previous state-of-the-art approaches across multiple datasets. Benefiting from integrating prior knowledge, DeepCCDS exhibits powerful feature representation capabilities and interpretability. Based on these feature representations, we have identified embedding features that could potentially be used for drug screening in new indications. Further, this work demonstrates the applicability of DeepCCDS on solid tumor samples from The Cancer Genome Atlas. This work believes integrating DeepCCDS into clinical decision-making processes can potentially improve the selection of personalized treatment strategies for cancer patients.}, archive = {J_ADVS}, author = {Jiashuo Wu and Jiyin Lai and Xilong Zhao and Ziyi Wang and Yongbao Zhang and Liqiang Wang and Yinchun Su and Yalan He and Siyuan Li and Ying Jiang and Junwei Han}, doi = {10.1002/advs.202416958}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2416958}, shortjournal = {Adv. Sci.}, title = {DeepCCDS: Interpretable deep learning framework for predicting cancer cell drug sensitivity through characterizing cancer driver signals}, volume = {12}, year = {2025}, }
• (2025). Gelsolin's protective role in MASH through F-actin regulation and p53 degradation. ADVS, 12(23), 2416489. (www)

  @article{ , abstract = {Hepatic steatosis, inflammation, and fibrosis are the hallmarks of metabolic-associated steatohepatitis (MASH), a serious health risk. This study emphasizes how important gelsolin (GSN) is to the pathophysiology of MASH. The results show that GSN is significantly overexpressed in both MASH patients and animal models. Under MASH models, Gsn knockout (KO) ( Gsn −/− ) mice demonstrate exacerbated hepatic steatosis, inflammation, and fibrosis, underscoring GSN's protective function. Remarkably, adeno-associated virus (AAV)-mediated restoration of Gsn substantially alleviates these pathological features, indicating its therapeutic potential. Mechanistically, the absence of GSN leads to increased F-actin polymerization and heightened activation of Yes-associated protein (YAP), thereby intensifying the inflammatory response. Subsequently, the experimental data identify a co-expression relationship between GSN and MDM2, and GSN is found to facilitate the ubiquitination and subsequent degradation of P53 via MDM2, a crucial process for liver protection. These findings imply that GSN is essential for controlling important molecular pathways in MASH by encouraging P53's MDM2-mediated degradation, which lessens the severity of hepatic steatosis. The research offers important new understandings of the molecular mechanisms of MASH and suggests GSN as a viable therapeutic target to reduce liver damage and preserve hepatic homeostasis.}, archive = {J_ADVS}, author = {Yiwei Lu and Tong Ji and Zhichao Ye and Jianing Yan and Chao Wang and Jiachen Chen and Ziyang Jin and Yongji Zhu and Xiujun Cai and Yifan Wang}, doi = {10.1002/advs.202416489}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2416489}, shortjournal = {Adv. Sci.}, title = {Gelsolin's protective role in MASH through F-actin regulation and p53 degradation}, volume = {12}, year = {2025}, }
• (2025). S-ketamine alleviates neuroinflammation and attenuates lipopolysaccharide-induced depression via targeting SIRT2. ADVS, 12(23), 2416481. (www)

  @article{ , abstract = {Depression, a pervasive mental health condition, has increasingly been linked to neuroinflammation, as evidenced by elevated levels of pro-inflammatory markers such as TNF-α and IL-1β observed in patients, which underscores the role of inflammation in its pathophysiology. This study investigates the differential effects of S-ketamine (S-KET) and R-ketamine (R-KET) on inflammation-induced depression using a lipopolysaccharide (LPS)-induced mouse model. Results showed that S-KET, but not R-KET, significantly alleviated depressive-like behaviors and reduced levels of pro-inflammatory factors in the medial prefrontal cortex (mPFC). Activity-based protein profiling identified SIRT2 as a key intracellular target of S-KET, with direct binding observed at the Q167 residue, whereas R-KET showed no such binding. S-KET enhanced SIRT2 interaction with NF-κB subunit p65, reducing its acetylation and suppressing pro-inflammatory gene expression, effects not seen with R-KET. In vitro studies with RNA interference and the SIRT2 inhibitor AK-7, along with in vivo pharmacological blockade, confirmed that SIRT2 is crucial for the anti-inflammatory and antidepressant actions of S-KET. These findings suggest that SIRT2 mediates the therapeutic effects of S-KET, highlighting its potential as a target for treating inflammation-associated depression. This study provides novel insights into the stereospecific actions of ketamine enantiomers and the promise of targeting SIRT2 for neuroinflammatory depression.}, archive = {J_ADVS}, author = {Cong Lin and Xiaoxuan Zhou and Mingqi Li and Cong Zhang and Haojiang Zhai and Haohong Li and Hongshuang Wang and Xiaohui Wang}, doi = {10.1002/advs.202416481}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2416481}, shortjournal = {Adv. Sci.}, title = {S-ketamine alleviates neuroinflammation and attenuates lipopolysaccharide-induced depression via targeting SIRT2}, volume = {12}, year = {2025}, }
• (2025). Cardiomyocyte-enriched USP20 ameliorates pathological cardiac hypertrophy by targeting STAT3 deubiquitination. ADVS, 12(23), 2416478. (www)

  @article{ , abstract = {Although pathological cardiac hypertrophy is a key driver of heart failure, the underlying mechanisms remain incompletely elucidated. This study investigates the role and mechanism of deubiquitinating enzyme (DUB) ubiquitin-specific protease 20 (USP20) in cardiac hypertrophy. Transcriptomic profiling of hypertrophic hearts shows significant alterations in the expression of DUBs, including a remarkable downregulation of USP20. USP20 is predominantly expressed in cardiomyocytes. Co-immunoprecipitation (Co-IP) followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to identify USP20 substrates. Cleavage Under Targets and Tagmentation assay (CUT&Tag) sequencing is employed to identify downstream targets of signal transducer and activator of transcription 3 (STAT3). Functionally, USP20 deficiency exacerbates cardiac hypertrophy induced by either angiotensin II (Ang II) or transverse aortic constriction (TAC), whereas USP20 overexpression alleviates hypertrophic responses. Mechanistically, USP20 deubiquitinates STAT3 by removing K63-linked ubiquitin chains at K177 via its H645 active site, reducing STAT3 phosphorylation and nuclear translocation. This inhibites STAT3's transcriptional activity at coactivator-associated arginine methyltransfer ( Carm1) promoter, leading to upregulated CARM1 expression and mitigated hypertrophy. Importantly, the STAT3 inhibitor Stattic confirms STAT3 serves as a key substrate mediating the cardiac protective effects of USP20. These findings unveil a novel USP20/STAT3/CARM1 axis in cardiomyocytes and reveal its therapeutic potential for cardiac hypertrophy.}, archive = {J_ADVS}, author = {Lingfeng Zhong and Shanshan Dai and Fan Yu and Guo-Ping Shi and Qinyan Gong and Yucong Zhang and Jingsi Duan and Zhengyin Lou and Zhixuan Tang and Fuzhe Gong and Derong Chen and Liya Hou and Xinyang Hu and Jinghai Chen and Jian'an Wang and Deling Yin}, doi = {10.1002/advs.202416478}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2416478}, shortjournal = {Adv. Sci.}, title = {Cardiomyocyte-enriched USP20 ameliorates pathological cardiac hypertrophy by targeting STAT3 deubiquitination}, volume = {12}, year = {2025}, }
• (2025). Unveiling multi-scale architectural features in single-cell hi-C data using scCAFE. ADVS, 12(23), 2416432. (www)

  @article{ , abstract = {Single-cell Hi-C (scHi-C) has provided unprecedented insights into the heterogeneity of 3D genome organization. However, its sparse and noisy nature poses challenges for computational analyses, such as chromatin architectural feature identification. Here, scCAFE is introduced, which is a deep learning model for the multi-scale detection of architectural features at the single-cell level. scCAFE provides a unified framework for annotating chromatin loops, TAD-like domains (TLDs), and compartments across individual cells. This model outperforms previous scHi-C loop calling methods and delivers accurate predictions of TLDs and compartments that are biologically consistent with previous studies. The resulting single-cell annotations also offer a measure to characterize the heterogeneity of different levels of architectural features across cell types. This heterogeneity is then leveraged to identify a series of marker loop anchors, demontrating the potential of the 3D genome data to annotate cell identities without the aid of simultaneously sequenced omics data. Overall, scCAFE not only serves as a useful tool for analyzing single-cell genomic architecture, but also paves the way for precise cell-type annotations solely based on 3D genome features.}, archive = {J_ADVS}, author = {Fuzhou Wang and Jiecong Lin and Hamid Alinejad-Rokny and Wenjing Ma and Lingkuan Meng and Lei Huang and Jixiang Yu and Nanjun Chen and Yuchen Wang and Zhongyu Yao and Weidun Xie and Ka-Chun Wong and Xiangtao Li}, doi = {10.1002/advs.202416432}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2416432}, shortjournal = {Adv. Sci.}, title = {Unveiling multi-scale architectural features in single-cell hi-C data using scCAFE}, volume = {12}, year = {2025}, }
• (2025). MTFR2-mediated fission drives fatty acid and mitochondrial co-transfer from hepatic stellate cells to tumor cells fueling oncogenesis. ADVS, 12(23), 2416419. (www)

  @article{ , abstract = {The tumor margin of hepatocellular carcinoma (HCC) is a critical zone where cancer cells invade the surrounding stroma, exhibiting unique and more invasive metabolic and migratory features compared to the tumor center, driving tumor expansion beyond the primary lesion. Studies have shown that at this critical interface, HCC cells primarily rely on fatty acid oxidation to meet their energy demands, although the underlying mechanisms remain unclear. This study demonstrates that activated hepatic stellate cells (HSCs) at the tumor margin play a pivotal role in sustaining the metabolic needs of HCC cells. Specifically, it is discovered that mitochondrial fission regulator 2 (MTFR2) in HSCs interacts with dynamin-related protein 1 (DRP1, a known mitochondrial fission machinery), preventing its lysosomal degradation, which in turn promotes mitochondrial fission. This MTFR2-driven mitochondrial fission enhances the transfer of both fatty acids and mitochondria to HCC cells, supplying essential metabolic substrates and reinforcing the mitochondrial machinery critical for tumor growth. The findings suggest that targeting MTFR2-driven mitochondrial fission may offer a novel therapeutic avenue for interfering with the metabolic crosstalk between tumor cells and the stromal niche.}, archive = {J_ADVS}, author = {La Zhang and Baoyong Zhou and Jun Yang and Cong Ren and Jing Luo and Zhenghang Li and Qiang Liu and Zuotian Huang and Zhongjun Wu and Ning Jiang}, doi = {10.1002/advs.202416419}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2416419}, shortjournal = {Adv. Sci.}, title = {MTFR2-mediated fission drives fatty acid and mitochondrial co-transfer from hepatic stellate cells to tumor cells fueling oncogenesis}, volume = {12}, year = {2025}, }
• (2025). The lung microbiome modulates pain-like behavior via the Lung–Brain axis in a nitroglycerin-induced chronic migraine mouse model. ADVS, 12(23), 2416348. (www)

  @article{ , abstract = {Chronic migraine is one of the most common pain disorders, characterized by significant disability and a lack of safe, long-term, and effective treatment options. Recent studies highlight the interaction between the lung microbiota and the central nervous system. In this study, a nitroglycerin (NTG)-induced chronic migraine model is constructed in male C57BL/6 mice to explore these interactions. Notable alterations are observed in the lung microbiota of migraine-afflicted mice. Notably, there is a marked decrease in Proteobacteria in the chronic migraine group, associated with short-chain fatty acids and 5-hydroxytryptamine (5-HT). After the intratracheal injection of neomycin, the diversity of the lung microbiota is altered, resulting in the relief of migraines. This effect is also observed in mice that receive neomycin-treated bronchoalveolar lavage fluid (BALF) transplantation, further demonstrating the role of lung microbiota in this process. The altered lung microbiota activate the pulmonary vagus nerve via the Brain-derived neurotrophic factor-tropomyosin receptor kinase B (BDNF-TrkB) pathway in the lung, which projects to the central nucleus of the solitary tract (NTS) and the dorsal raphe nucleus (DRN). This activation, in turn, stimulates the 5-HT neurons in the DRN, resulting in increased serotonin levels that contribute to pain relief in the chronic migraine model.}, archive = {J_ADVS}, author = {Biying Liu and Chengya Huang and Xin Li and Haonan Yu and Yuefeng Xia and Kun Liu and Xingji You and Jingxiang Wu}, doi = {10.1002/advs.202416348}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2416348}, shortjournal = {Adv. Sci.}, title = {The lung microbiome modulates pain-like behavior via the Lung–Brain axis in a nitroglycerin-induced chronic migraine mouse model}, volume = {12}, year = {2025}, }
• (2025). Targeted delivery of α-ketoglutarate to macrophages in bone: A novel therapeutic strategy for improving fracture healing in type 2 diabetes. ADVS, 12(23), 2415667. (www)

  @article{ , abstract = {Impaired fracture healing is a common complication in type 2 diabetes mellitus (T2DM), with limited effective treatments. This study investigates the role of macrophages in bone repair and introduces a novel therapeutic strategy. Reduced glutaminase (GLS) expression and glutaminolysis are found in macrophages from T2DM mice and monocytes from T2DM patients. Specific deletion of GLS in macrophages altered their phenotypes and delayed fracture healing in mice. Mechanistically, GLS deficiency reduced α-ketoglutarate (α-KG) levels in macrophages, which impairs bone morphogenetic protein 2 (BMP2) production by increasing cytosine methylation on the promoter, ultimately hindering osteogenic differentiation of bone marrow mesenchymal stem cells. Importantly, while systemic α-KG supplementation deteriorates fracture healing in T2DM mice, a targeted delivery of α-KG using α-KG@Cy5.5@ALN-Liposome to macrophages in bone markedly improves fracture healing. These findings underscore the critical role of macrophage glutaminolysis in fracture healing and propose targeted α-KG delivery as a promising therapeutic intervention for improving fracture repair in T2DM patients.}, archive = {J_ADVS}, author = {Jing Wang and Jiahao Cao and Siqi Zhang and Hongli Chen and Xuebing Yu and Xinli Wang and Tianji Wang and Wei Cao and Wengang Dong and Xinsen Lin and Jia Li and Wei Lei and Yafei Feng}, doi = {10.1002/advs.202415667}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2415667}, shortjournal = {Adv. Sci.}, title = {Targeted delivery of α-ketoglutarate to macrophages in bone: A novel therapeutic strategy for improving fracture healing in type 2 diabetes}, volume = {12}, year = {2025}, }
• (2025). Simultaneous harvesting of bipolar plasmonic hot carriers for boosting photoconductivity in ag nanoprism-coupled lateral si p–n junction. ADVS, 12(23), 2414654. (www)

  @article{ , abstract = {Plasmonic hot carriers have garnered considerable attention in photovoltaics and photocatalysis, yet their full potential is limited by the challenge of harvesting both positive and negative polarity hot carriers at the same time. Here, an unprecedented plasmonic hot carrier device capable of extracting both types of hot carriers simultaneously is demonstrated. This scheme involves generating and harnessing plasmonic hot electrons and holes concurrently using a lateral Si p–n junction diode coupled to Ag nanoprisms. The experimental and numerical results jointly reveal precise control of the generation and injection of plasmonic hot carriers, stemming from differing injection probabilities of each type of hot carrier into the substrates. It is shown that the bipolar plasmonic photodetector exhibits outstanding performance compared to plasmonic devices utilizing single-polarity hot carriers, attributed to the simultaneous participation of plasmonic hot carriers in the photoconductivity nature of the diode. It is believed that this strategy of harnessing bipolar hot carriers will pave the way for the rational design of future plasmonic applications by providing significantly improved photoconductivity and flexible utilization of hot carriers.}, archive = {J_ADVS}, author = {Yujin Park and Jihyang Park and Yeonghoon Jin and Yujin Roh and Hyunhwa Lee and Kyoungsik Yu and Moonsang Lee and Jeong Young Park}, doi = {10.1002/advs.202414654}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2414654}, shortjournal = {Adv. Sci.}, title = {Simultaneous harvesting of bipolar plasmonic hot carriers for boosting photoconductivity in ag nanoprism-coupled lateral si p–n junction}, volume = {12}, year = {2025}, }
• (2025). Efficient and specific PDGFRβ-targeting dual-mode t1-t2 MRI nanoprobe for early diagnosis of non-alcoholic fatty liver. ADVS, 12(23), 2413788. (www)

  @article{ , abstract = {Non-alcoholic fatty liver disease (NAFLD)-induced early-stage liver fibrosis is increasingly common. Non-invasive MRI detection offers an important diagnostic method to prevent fibrosis from progressing to cirrhosis or hepatocellular carcinoma. However, because fibrosis is confined to the periportal areas, and changes in tissue structure and stiffness are minimal, standard T 1 - or T 2 -weighted imaging struggles to capture these early-stage lesions. To address this challenge, a highly sensitive and targeted T 1 -T 2 dual-mode magnetic resonance imaging (MRI) nanoprobe is designed and developed, specifically targeting early-stage liver fibrosis characterized by the activation of hepatic stellate cells (HSCs) and the overexpression of platelet-derived growth factor receptor β (PDGFRβ). The nanoprobe exhibits excellent relaxivity (r 2 /r 1 = 10.7) and precise targeting due to PDGFRβ-specific peptides conjugated to its protein nanocage. In vivo, imaging in animal models demonstrate effective accumulation of the probe in fibrotic regions as NAFLD progressed, with fluorescence signal intensity accurately reflecting the severity of liver fibrosis. Using a 7T MRI system, T 1 and T 2 images are overlaid within 1 h, accurately locating fibrotic areas and improving diagnostic speed and precision. The nanoprobe shows excellent biocompatibility and enhances early fibrosis detection in NAFLD, offering significant clinical potential for early diagnosis, prognosis, and recurrence monitoring.}, archive = {J_ADVS}, author = {Zehua Li and Tongwei Zhang and Tongxiang Tao and Yaxuan Liu and Haining Xia and Sajid ur Rehman and Zeyong Guo and Jing Zhang and Ruiguo Chen and Zhan Zhang and Junfeng Wang and Kun Ma}, doi = {10.1002/advs.202413788}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2413788}, shortjournal = {Adv. Sci.}, title = {Efficient and specific PDGFRβ-targeting dual-mode t1-t2 MRI nanoprobe for early diagnosis of non-alcoholic fatty liver}, volume = {12}, year = {2025}, }
• (2025). Epileptiform activity and seizure risk follow long-term non-linear attractor dynamics. ADVS, 12(23), 2411829. (www)

  @article{ , abstract = {Many biological systems display circadian and slow multi-day rhythms, such as hormonal and cardiac cycles. In patients with epilepsy, these cycles also manifest as slow cyclical fluctuations in seizure propensity. However, such fluctuations in symptoms are consequences of the complex interactions between the underlying physiological, pathophysiological, and external causes. Therefore, identifying an accurate model of the underlying system that governs the multi-day rhythms allows for a more reliable seizure risk forecast and targeted interventions. The primary aim is to develop a personalized strategy for inferring long-term trajectories of epileptiform activity and, consequently, seizure risk for individual patients undergoing long-term ECoG sampling via implantable neurostimulation devices. To achieve this goal, the Hankel alternative view of Koopman (HAVOK) analysis is adopted to approximate a linear representation of nonlinear seizure propensity dynamics. The HAVOK framework leverages Koopman theory and delay-embedding to decompose chaotic dynamics into a linear system of leading delay-embedded coordinates driven by the low-energy coordinate (i.e., forcing). The findings reveal the topology of attractors underlying multi-day seizure cycles, showing that seizures tend to occur in regions of the manifold with strongly nonlinear dynamics. Moreover, it is demonstrated that the identified system driven by forcings with short periods up to a few days accurately predicts patients' slower multi-day rhythms, which improves seizure risk forecasting.}, archive = {J_ADVS}, author = {Richard E Rosch and Brittany Scheid and Kathryn A Davis and Brian Litt and Arian Ashourvan}, doi = {10.1002/advs.202411829}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2411829}, shortjournal = {Adv. Sci.}, title = {Epileptiform activity and seizure risk follow long-term non-linear attractor dynamics}, volume = {12}, year = {2025}, }
• (2025). Coordinated role of autophagy and ERAD in maintaining neuroendocrine function by preventing prohormone aggregation. ADVS, 12(23), 2411662. (www)

  @article{ , abstract = {Proteotoxicity induced by misfolded or aggregated proteins causes progressive neuronal damage. The endoplasmic reticulum (ER) protein quality control (ERQC) pathways are responsible for mitigating the accumulation of these misfolded or aggregated proteins, thus reducing proteotoxicity. Enhancing ERQC pathways is a promising strategy for treating neurodegenerative diseases. However, the mechanisms governing the initiation and degradation of misfolded or aggregated proteins in neurons remain largely unknown in vivo. In studying the maturation of proAVP in mouse AVP neurons, this study discovers that autophagy and ER-associated degradation (ERAD) ERQC pathways collaborate to maintain proAVP maturation and protect AVP neuron survival against proteotoxicity. Autophagy deficiency in mouse AVP neurons leads to the late-onset of diabetes insipidus. Mechanistically, autophagy selectively degrades mutant proAVP aggregates and endogenous HRD1 of the SEL1L-HRD1 ERAD complex through FAM134B mediated ER-phagy. HRD1 induction is responsible for reducing proAVP aggregation and maintaining AVP neuron function and survival under autophagy deficiency. Thus, autophagy and ERAD form a dual-protection system that orchestrates prohormone maturation and endocrine neuron survival, providing new insights in the complexity of neuroendocrinology and the intrinsic mechanism of neurodegenerative diseases, with therapeutic potential in protein folding diseases.}, archive = {J_ADVS}, author = {Xuya Pan and Xing He and Su Wu and Na Xiong and Xinyu Hou and Heting Wang and Diane Somlo and Martin Spiess and Haiyang Wang and Jifeng Yang and Chunliang Li and Shasha Li and Wenbin Ma and Yanming Chen and Jun Cui and Ling Qi and Guojun Shi}, doi = {10.1002/advs.202411662}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2411662}, shortjournal = {Adv. Sci.}, title = {Coordinated role of autophagy and ERAD in maintaining neuroendocrine function by preventing prohormone aggregation}, volume = {12}, year = {2025}, }
• (2025). Recent advancements in lung cancer metastasis prevention based on nanostrategies. ADVS, 12(23), 2409293. (www)

  @article{ , abstract = {Metastasis is the leading cause of death in patients with lung cancer. Multidisciplinary comprehensive treatments (MDT), including surgery, chemotherapy, radiotherapy, gene-targeted therapy, immunotherapy, antibody-drug conjugate (ADC), natural products, etc., have been currently used for lung cancer metastasis. The MDT model has shown promising efficacy against lung cancer metastasis in clinical practice. However, these therapies have some limitations, such as unusual toxic side effects, drug resistance, limited indications, and high costs. Therefore, emerging technological platforms are imperative to overcome these bottlenecks. Nanomedicine can be used to prepare efficient drug delivery systems owing to its good biocompatibility, high targeting, responsive release, and multidrug codelivery and plays an important role in the synergistic antimetastasis of lung cancer because of the optical, acoustic, electrical, thermal, and magnetic functions. This comprehensive review analyses the limitations of the MDT model, briefly outlines the advantages of nanotechnology, introduces the promising nanodrug delivery systems, summarizes the emerging nanostrategies against lung cancer metastasis based on the invasion-metastasis cascade process, and provides a summary of the prospects and challenges for the clinical translation of nanomedicines.}, archive = {J_ADVS}, author = {Fan Xu and Yao Liu and Zujun Que and Bin Luo and Yun Yang and Yan Li and Zhanxia Zhang and Jianhui Tian}, doi = {10.1002/advs.202409293}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2409293}, shortjournal = {Adv. Sci.}, title = {Recent advancements in lung cancer metastasis prevention based on nanostrategies}, volume = {12}, year = {2025}, }
• (2025). Immune checkpoint PD-l1 modulates retinal microglial activation to alleviate vascular leakage in choroidal neovascularization via ERK. ADVS, 12(23), 2400747. (www)

  @article{ , abstract = {Neovascular age-related macular degeneration (NVAMD) is a common retinal disease causing vision loss in the elderly. Neuroinflammation significantly contributes to NVAMD's etiology. This study explores the role of Programmed cell death ligand 1 (PD-L1), an immune checkpoint (ICP) in microglia, known for limiting neuroinflammation in neurodegenerative diseases, and its potential function in NVAMD. This work finds increased PD-L1 expression in retinal microglia following laser injury. PD-L1 knockout (KO) or inhibitory PD-L1 antibody treatment worsens vascular leakage and neoangiogenesis in a laser-induced NVAMD mouse model, effects reversible by microglia depletion with PLX5622. This study underscores that choroidal neovascularization (CNV) may be regulated by multiple mechanisms, with PD-L1 modulation representing one of these pathways. Blocking PD-L1 elevated proinflammatory factors and p-ERK levels, indicating microglial overactivation in NVAMD. Conversely, enhancing PD-L1 signaling reduced neuroinflammation and neovascularization via ERK. These findings highlight PD-L1's role in neoangiogenesis and neuroinflammation in NVAMD, suggesting its potential as a target for immunomodulatory treatment in NVAMD.}, archive = {J_ADVS}, author = {Yue Zou and Junliang Jiang and Yunqin Li and Xinyi Ding and Qiuping Tong and Ying Shi and Lei Xiao and Ling Chen}, doi = {10.1002/advs.202400747}, journal = {Advanced Science}, month = {6}, number = {23}, pages = {2400747}, shortjournal = {Adv. Sci.}, title = {Immune checkpoint PD-l1 modulates retinal microglial activation to alleviate vascular leakage in choroidal neovascularization via ERK}, volume = {12}, year = {2025}, }
• (2025). Engineered hydrogels for organoid models of human nonalcoholic fatty liver disease. ADVS, 12(22), e17332. (www)

  @article{ , abstract = {Nonalcoholic fatty liver disease (NAFLD) is characterized by increased lipid accumulation and excessive deposition of extracellular matrix (ECM) that results in tissue stiffening. The potential interplay between matrix stiffness and hepatocyte lipid accumulation during NAFLD has not been established. Here, an in vitro NAFLD model is developed using chemically defined, engineered hydrogels and human induced pluripotent stem cell-derived hepatic organoids (HOs). Specifically, dynamic covalent chemistry crosslinking, along with transient small molecule competitors, are used to create dynamic stiffening hydrogels that enable the reproducible culture of HOs. Within matrices that mimic the stiffness of healthy to diseased tissue (≈1–6 kPa), lipid droplet accumulation in HOs is triggered by exposure to an NAFLD-associated free fatty acid. These NAFLD model suggests that higher stiffness microenvironments result in increased hepatic lipid droplet accumulation, increased expression of fibrosis markers, and increased metabolic dysregulation. By targeting the ROCK mechanosignaling pathway, the synergy between matrix stiffness and lipid droplet accumulation is disrupted. The in vitro model of NAFLD has the potential to understand the role of mechanosignaling in disease progression and identify new pathways for therapeutic intervention.}, archive = {J_ADVS}, author = {Yueming Liu and Aidan E. Gilchrist and Patrik K. Johansson and Yuan Guan and Jaydon D. Deras and Yu-Chung Liu and Sofia Ceva and Michelle S. Huang and Renato S. Navarro and Annika Enejder and Gary Peltz and Sarah C. Heilshorn}, doi = {10.1002/advs.202417332}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {e17332}, shortjournal = {Adv. Sci.}, title = {Engineered hydrogels for organoid models of human nonalcoholic fatty liver disease}, volume = {12}, year = {2025}, }
• (2025). Integrative multi-omics and routine blood analysis using deep learning: Cost-effective early prediction of chronic disease risks (Adv. sci. 22/2025). ADVS, 12(22), 2570175. (www)

  @article{ , archive = {J_ADVS}, author = {Zhibin Dong and Pei Li and Yi Jiang and Zhihan Wang and Shihui Fu and Hebin Che and Meng Liu and Xiaojing Zhao and Chunlei Liu and Chenghui Zhao and Qin Zhong and Chongyou Rao and Siwei Wang and Suyuan Liu and Dayu Hu and Dongjin Wang and Juntao Gao and Kai Guo and Xinwang Liu and En Zhu and Kunlun He}, doi = {10.1002/advs.202570175}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2570175}, shortjournal = {Adv. Sci.}, title = {Integrative multi-omics and routine blood analysis using deep learning: Cost-effective early prediction of chronic disease risks (Adv. sci. 22/2025)}, volume = {12}, year = {2025}, }
• (2025). Knowledge distillation for molecular property prediction: A scalability analysis (Adv. sci. 22/2025). ADVS, 12(22), 2570174. (www)

  @article{ , archive = {J_ADVS}, author = {Rahul Sheshanarayana and Fengqi You}, doi = {10.1002/advs.202570174}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2570174}, shortjournal = {Adv. Sci.}, title = {Knowledge distillation for molecular property prediction: A scalability analysis (Adv. sci. 22/2025)}, volume = {12}, year = {2025}, }
• (2025). Targeted STING activation using modified ultrasound-responsive microbubbles enhances immune checkpoint blockade against melanoma (Adv. sci. 22/2025). ADVS, 12(22), 2570173. (www)

  @article{ , archive = {J_ADVS}, author = {Sina Khorsandi and Kristin Huntoon and Yifan Wang and Adam Woodward and Abin Antony and Connor Endsley and Nazia Hafeez and Jared L. Edwards and Nicole McCuen and Prasanna G. Alluri and Betty Y.S. Kim and Wen Jiang and Jacques Lux}, doi = {10.1002/advs.202570173}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2570173}, shortjournal = {Adv. Sci.}, title = {Targeted STING activation using modified ultrasound-responsive microbubbles enhances immune checkpoint blockade against melanoma (Adv. sci. 22/2025)}, volume = {12}, year = {2025}, }
• (2025). Metal–Organic frameworks: Unlocking new frontiers in cardiovascular diagnosis and therapy (Adv. sci. 22/2025). ADVS, 12(22), 2570172. (www)

  @article{ , archive = {J_ADVS}, author = {Qilu Wu and Yuxiao Feng and Mathilde Lepoitevin and Meng Yu and Christian Serre and Jun Ge and Yuan Huang}, doi = {10.1002/advs.202570172}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2570172}, shortjournal = {Adv. Sci.}, title = {Metal–Organic frameworks: Unlocking new frontiers in cardiovascular diagnosis and therapy (Adv. sci. 22/2025)}, volume = {12}, year = {2025}, }
• (2025). Label-free dual-modal Photoacoustic/Ultrasound localization imaging for studying acute kidney injury (Adv. sci. 22/2025). ADVS, 12(22), 2570170. (www)

  @article{ , archive = {J_ADVS}, author = {Shensheng Zhao and Xingxing Zhang and Keith Bailey and Sathvik Pai and Yang Zhao and Yun-Sheng Chen}, doi = {10.1002/advs.202570170}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2570170}, shortjournal = {Adv. Sci.}, title = {Label-free dual-modal Photoacoustic/Ultrasound localization imaging for studying acute kidney injury (Adv. sci. 22/2025)}, volume = {12}, year = {2025}, }
• (2025). Apoptotic vesicles derived from mesenchymal stem cells ameliorate hypersensitivity responses via inducing CD8+ t cells apoptosis with calcium overload and mitochondrial dysfunction (Adv. sci. 22/2025). ADVS, 12(22), 2570169. (www)

  @article{ , archive = {J_ADVS}, author = {Anqi Liu and Peng Peng and Changze Wei and Fanhui Meng and Xiaoyao Huang and Peisheng Liu and Siyuan Fan and Xinyue Cai and Meiling Wu and Zilin Xuan and Qing Liu and Xinyu Qiu and Zhenlai Zhu and Hao Guo}, doi = {10.1002/advs.202570169}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2570169}, shortjournal = {Adv. Sci.}, title = {Apoptotic vesicles derived from mesenchymal stem cells ameliorate hypersensitivity responses via inducing CD8+ t cells apoptosis with calcium overload and mitochondrial dysfunction (Adv. sci. 22/2025)}, volume = {12}, year = {2025}, }
• (2025). Correlation between fecal microbiota and corticosteroid responsiveness in primary immune thrombocytopenia: An exploratory study (Adv. sci. 22/2025). ADVS, 12(22), 2570168. (www)

  @article{ , archive = {J_ADVS}, author = {Feng-Qi Liu and Zhuo-Yu An and Li-Juan Cui and Meng-Yu Xiao and Ye-Jun Wu and Wei Li and Bang-Shuo Zhang and Li Yu and Jia Feng and Zhuo-Gang Liu and Ru Feng and Zhong-Xing Jiang and Rui-Bin Huang and Hong-Mei Jing and Jin-Hai Ren and Xiao-Yu Zhu and Yun-Feng Cheng and Yu-Hua Li and He-Bing Zhou and Da Gao and Yi Liu and Fan Yu and Xin Wang and Jian-Lin Qiao and Dai-Hong Hu and Lu-Lu Wang and Meng-Tong Zang and Qi Chen and Qing-Yuan Qu and Jian-Ying Zhou and Meng-Lin Li and Yu-Xiu Chen and Qiu-Sha Huang and Hai-Xia Fu and Yue-Ying Li and Qian-Fei Wang and Xiao-Jun Huang and Xiao-hui Zhang}, doi = {10.1002/advs.202570168}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2570168}, shortjournal = {Adv. Sci.}, title = {Correlation between fecal microbiota and corticosteroid responsiveness in primary immune thrombocytopenia: An exploratory study (Adv. sci. 22/2025)}, volume = {12}, year = {2025}, }
• (2025). Origins, dispersal, and impact: Bidirectional introgression between chinese and european pig populations (Adv. sci. 22/2025). ADVS, 12(22), 2570167. (www)

  @article{ , archive = {J_ADVS}, author = {Yibin Qiu and Langqing Liu and Min Huang and Donglin Ruan and Rongrong Ding and Zebin Zhang and Enqin Zheng and Shiyuan Wang and Shaoxiong Deng and Xianglun Meng and Xinyan Cheng and Jiaxin Shi and Yingshan Yang and Fuchen Zhou and Sixiu Huang and Huaqiang Yang and Zicong Li and Gengyuan Cai and Zhenfang Wu and Jie Yang}, doi = {10.1002/advs.202570167}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2570167}, shortjournal = {Adv. Sci.}, title = {Origins, dispersal, and impact: Bidirectional introgression between chinese and european pig populations (Adv. sci. 22/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “DAPK3 is essential for DBP-induced autophagy of mouse leydig cells”. ADVS, 12(22), 2504678. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202504678}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2504678}, shortjournal = {Adv. Sci.}, title = {Correction to “DAPK3 is essential for DBP-induced autophagy of mouse leydig cells”}, volume = {12}, year = {2025}, }
• (2025). Knowledge distillation for molecular property prediction: A scalability analysis. ADVS, 12(22), 2503271. (www)

  @article{ , abstract = {Knowledge distillation (KD) is a powerful model compression technique that transfers knowledge from complex teacher models to compact student models, reducing computational costs while preserving predictive accuracy. This study investigated KD's efficacy in molecular property prediction across domain-specific and cross-domain tasks, leveraging state-of-the-art graph neural networks (SchNet, DimeNet++, and TensorNet). In the domain-specific setting, KD improved regression performance across diverse quantum mechanical properties in the QM9 dataset, with DimeNet++ student models achieving up to an 90% improvement in compared to non-KD baselines. Notably, in certain cases, smaller student models achieved comparable or even superior improvements while being 2× smaller, highlighting KD's ability to enhance efficiency without sacrificing predictive performance. Cross-domain evaluations further demonstrated KD's adaptability, where embeddings from QM9-trained teacher models enhanced predictions for ESOL (log S ) and FreeSolv (Δ G hyd ), with SchNet exhibiting the highest gains of ≈65% in log S predictions. Embedding analysis revealed substantial student-teacher alignment gains, with the relative shift in cosine similarity distribution peaks reaching up to 1.0 across student models. These findings highlighted KD as a robust strategy for enhancing molecular representation learning, with implications for cheminformatics, materials science, and drug discovery.}, archive = {J_ADVS}, author = {Rahul Sheshanarayana and Fengqi You}, doi = {10.1002/advs.202503271}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2503271}, shortjournal = {Adv. Sci.}, title = {Knowledge distillation for molecular property prediction: A scalability analysis}, volume = {12}, year = {2025}, }
• (2025). Mechanisms and therapeutic strategies for minority cell-induced paclitaxel resistance and tumor progression mediated by mechanical forces. ADVS, 12(22), 2417805. (www)

  @article{ , abstract = {Chemotherapy remains a prevalent strategy in cancer therapy; however, the emergence of drug resistance poses a considerable challenge to its efficacy. Most drug resistance arises from the accumulation of genetic mutations in a minority of resistant cells. The mechanisms underlying the emergence and progression of cancer resistance from these minority-resistant cells (MRCs) remain poorly understood. This study employs force-induced remnant magnetization spectroscopy (FIRMS) alongside various biological investigations to reveal the mechanical pathways for MRCs fostering drug resistance and tumor progression. The findings show that minority Paclitaxel-resistant cancer cells have enhanced mechanical properties. These cells can transmit high-intensity forces to surrounding sensitive cells (SCs) through the force transducer, Merlin. This force transmission facilitates the assimilation of surrounding SCs, subsequently strengthening the contraction and adhesion of tumor cells. This process is termed “mechano-assimilation,” which accelerates the development of drug resistance and tumor progression. Interestingly, disturbances and reductions of mechano-assimilation within tumors can restore sensitivity to Paclitaxel both in vitro and in vivo. This study provides preliminary evidence highlighting the contribution of MRCs to the development of drug resistance and malignancy, mediated through mechanical interactions. It also establishes a foundation for future research focused on integrating mechanical factors into innovative cancer therapies.}, archive = {J_ADVS}, author = {Xueyan Feng and Di Zhang and Guoxun Wang and Liwei Lu and Feng Feng and Xiuyu Wang and Chanchan Yu and Yahong Chai and Jin Zhang and Wenchao Li and Jing Liu and Hongxia Sun and Li Yao}, doi = {10.1002/advs.202417805}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417805}, shortjournal = {Adv. Sci.}, title = {Mechanisms and therapeutic strategies for minority cell-induced paclitaxel resistance and tumor progression mediated by mechanical forces}, volume = {12}, year = {2025}, }
• (2025). New insights into heavy metal sequestration through metal-phenolic network-confined nano-HFO: Overlooking iron utilization and modulating electron density. ADVS, 12(22), 2417798. (www)

  @article{ , abstract = {Reducing toxic metal concentrations to trace levels remains a critical challenge in water remediation, largely due to the underutilization of hydrous ferric oxide (HFO), particularly within its inner layers. Herein, we present a novel strategy to enhance HFO utilization by in situ confinement of nano-HFO within polystyrene beads using a tannic acid-zirconium (TA-Zr) metalphenolic network, forming PS-Fe@TA-Zr. The TAZr network generates a highly negative microenvironment with tunable electron density at oxygen sites, facilitating Pb(II) enrichment and activating inner-layer Fe sites. Depth-profiling reveals a significant increase in the Pb/Fe ratio from 7.6% at the surface to 18.8% at 10 nm depth, highlighting the contribution of previously inaccessible active sites. The TAZr confinement also modulates electron density at Fe and O sites, enabling stronger hybridization with Pb 4f orbitals and enhancing Pb(II)HFO interactions. Compared with PS-Fe, PS-Fe@TA-Zr exhibits over 8-fold higher selectivity (Kd = 15,278 mL g −1 ), 5-fold faster kinetics, and can treat up to 1,680 L kg −1 with effective regeneration across six cycles in actual industrial wastewater. This work provides new insights into metalphenolic network-assisted design of nanocomposites for highly efficient iron utilization in heavy metal removal.}, archive = {J_ADVS}, author = {Manyu Zhang and Xiaolin Du and Zhanqi Liu and Yujia Yang and Shuo Wang and Ningyi Chen and Yulin Wang and Yaran Song and Keju Sun and Qingrui Zhang}, doi = {10.1002/advs.202417798}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417798}, shortjournal = {Adv. Sci.}, title = {New insights into heavy metal sequestration through metal-phenolic network-confined nano-HFO: Overlooking iron utilization and modulating electron density}, volume = {12}, year = {2025}, }
• (2025). All-electrical control of spin synapses for neuromorphic computing: Bridging multi-state memory with quantization for efficient neural networks. ADVS, 12(22), 2417735. (www)

  @article{ , abstract = {The development of energy-efficient, brain-inspired neuromorphic computing demands advanced memory devices capable of mimicking synaptic behavior to achieve high accuracy and adaptability. In this study, three types of all-electrically controlled, field-free spin synapse devices designed with unique spintronic structures presented: the Néel orange-peel effect, interlayer Dzyaloshinskii-Moriya interaction (i-DMI), and tilted anisotropy. To systematically evaluate their neuromorphic potential, a benchmarking framework is introduced that characterizes cycle-to-cycle (CTC) variation, a critical factor for reliable synaptic weight updates. Among these designs, the tilted anisotropy device achieves an 11-state memory with minimal CTC variation (2%), making it particularly suited for complex synaptic emulation. Through comprehensive benchmarking, this multi-state device in convolutional neural networks (CNNs) using post-training quantization is implemented. Results indicate that per-channel quantization, particularly with the min-max and mean squared error (MSE) observers, enhances classification accuracy on the CIFAR-10 dataset, achieving up to 81.51% and 81.12% in ResNet-18—values that closely approach the baseline accuracy. This evaluation underscores the potential of field-free spintronic synapses in neuromorphic architectures, offering an area-efficient solution that integrates multi-state functionality with robust switching performance. The findings highlight the promise of these devices in advancing neuromorphic computing, contributing to energy-efficient, high-performance systems inspired by neural processes.}, archive = {J_ADVS}, author = {Tzu-Chuan Hsin and Chun-Yi Lin and Po-Chuan Wang and Chun Yang and Chi-Feng Pai}, doi = {10.1002/advs.202417735}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417735}, shortjournal = {Adv. Sci.}, title = {All-electrical control of spin synapses for neuromorphic computing: Bridging multi-state memory with quantization for efficient neural networks}, volume = {12}, year = {2025}, }
• (2025). Microglial MS4A4A protects against epileptic seizures in alzheimer's disease. ADVS, 12(22), 2417733. (www)

  @article{ , abstract = {Alzheimer's disease (AD) is a predominant neurodegenerative disorder worldwide, with epileptic seizures being a common comorbidity that can exacerbate cognitive deterioration in affected individuals, thus highlighting the importance of early therapeutic intervention. It is determined that deletion of Ms4a4a , an AD-associated gene, exacerbates seizures in amyloid β (Aβ)-driven AD mouse model. MS4A4A is significantly upregulated in brain lesions in patients with epilepsy. Single-cell sequencing reveals that MS4A4A is highly expressed in microglia within these lesions, linked to enhanced phagocytic activity. Mechanistic investigation delineates that deletion of Ms4a4a impairs microglial phagocytosis, accompanied by diminished calcium influx and disruptions in mitochondrial metabolic fitness. The cytosolic fragment of Ms4a4a is anchored to the cytoskeletal components, supporting its critical role in mediating phagocytosis. Induction of Ms4a4a through central delivery of LNP- Il4 alleviates seizure conditions. Collectively, these findings identify Ms4a4a as a potential therapeutic target for managing seizures in AD treatment.}, archive = {J_ADVS}, author = {Meng Jiang and Qingqing Li and Jianhui Chen and Ruochong Li and Jun Yao and Yong Hu and Haizheng Zhang and Lixin Cai and Maoguo Luo and Yu Sun and Wenwen Zeng}, doi = {10.1002/advs.202417733}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417733}, shortjournal = {Adv. Sci.}, title = {Microglial MS4A4A protects against epileptic seizures in alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). DiffMC-gen: A dual denoising diffusion model for multi-conditional molecular generation. ADVS, 12(22), 2417726. (www)

  @article{ , abstract = {The precise and efficient design of potential drug molecules with diverse physicochemical properties has long been a critical challenge. In recent years, the emergence of various deep learning-based de novo molecular generation algorithms offered new directions to this issue, among which denoising diffusion models have demonstrated significant potential. However, previous methods often fail to simultaneously optimize multiple properties of candidate compounds, which may stem from directly employing nongeometric graph neural networks (GNNs), rendering them incapable of accurately capturing molecular topologic and geometric information. In this study, a dual denoising diffusion model is developed for multi-conditional molecular generation (DiffMC-Gen), which integrates both discrete and continuous features to enhance its ability to perceive 3D molecular structures. Additionally, it involves a multi-objective optimization strategy to simultaneously optimize multiple properties of the target molecule, including binding affinity, drug-likeness, synthesizability, and toxicity. From the perspectives of both 2D and 3D molecular generation, the molecules generated by DiffMC-Gen exhibit state-of-the-art (SOTA) performance in terms of novelty and uniqueness, meanwhile achieving comparable results to previous methods in drug-likeness and synthesizability. Furthermore, the generated molecules have well-predicted biological activity and druglike properties for three target proteins—LRRK2, HPK1, and GLP-1 receptor, while also maintaining high standards of validity, uniqueness, and novelty. These results underscore its potential for practical applications in drug design.}, archive = {J_ADVS}, author = {Yuwei Yang and Shukai Gu and Bo Liu and Xiaoqing Gong and Ruiqiang Lu and Jiayue Qiu and Xiaojun Yao and Huanxiang Liu}, doi = {10.1002/advs.202417726}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417726}, shortjournal = {Adv. Sci.}, title = {DiffMC-gen: A dual denoising diffusion model for multi-conditional molecular generation}, volume = {12}, year = {2025}, }
• (2025). Chimeric nanozyme bacterial outer membrane vesicles reprograming tumor microenvironment for safe and efficient anticancer therapy. ADVS, 12(22), 2417712. (www)

  @article{ , abstract = {This study presents an innovative approach utilizing a biocompatible shell to shield bacterial outer membrane vesicles (OMVs) and incorporate Fe ions and ultrasmall Au nanoparticles to develop a combined tumor therapeutic strategy. These chimeric nanozyme shells effectively reduce the toxicity of OMVs during circulation and promote their accumulation in tumor tissues. In the tumor microenvironment, Au nanoparticles act as nanozymes, catalyzing glucose consumption and elevating H₂O₂ levels. The increased H₂O₂ subsequently reacts with the released Fe ions to induce immunogenic tumor cell death through iron-mediated chemodynamic mechanisms. Simultaneously, the release of tumor-associated antigens and OMVs synergistically stimulates the immune response. This cascade of nanozyme-catalyzed reactions, chemodynamic effects, and immune activation results in efficient tumor inhibition.}, archive = {J_ADVS}, author = {Fan Zhang and Qianqian Li and Haibing Dai and Weiqun Li and Xiang Chen and Huibin Wu and Shanming Lu and Ran Luo and Feng Li and Guihong Lu and Jianbo Yu and Lin Mei}, doi = {10.1002/advs.202417712}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417712}, shortjournal = {Adv. Sci.}, title = {Chimeric nanozyme bacterial outer membrane vesicles reprograming tumor microenvironment for safe and efficient anticancer therapy}, volume = {12}, year = {2025}, }
• (2025). A novel dual-network approach for real-time liveweight estimation in precision livestock management. ADVS, 12(22), 2417682. (www)

  @article{ , abstract = {The increasing demand for automation in livestock farming scenarios highlights the need for effective noncontact measurement methods. The current methods typically require either fixed postures and specific positions of the target animals or high computational demands, making them difficult to implement in practical situations. In this study, a novel dual-network framework is presented that extracts accurate contour information instead of segmented images from unconstrained pigs and then directly employs this information to obtain precise liveweight estimates. The experimental results demonstrate that the developed framework achieves high accuracy, providing liveweight estimates with an R 2 value of 0.993. When contour information is used directly to estimate the liveweight, the real-time performance of the framework can reach 1131.6 FPS. This achievement sets a new benchmark for accuracy and efficiency in non-contact liveweight estimation. Moreover, the framework holds significant practical value, equipping farmers with a robust and scalable tool for precision livestock management in dynamic, real-world farming environments. Additionally, the Liveweight and Instance Segmentation Annotation of Pigs dataset is introduced as a comprehensive resource designed to support further advancements and validation in this field.}, archive = {J_ADVS}, author = {Ximing Dong and Caiming Zhang and Peiyuan Wang and Dexuan Chen and Gang Jun Tu and Shuhong Zhao and Tao Xiang}, doi = {10.1002/advs.202417682}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417682}, shortjournal = {Adv. Sci.}, title = {A novel dual-network approach for real-time liveweight estimation in precision livestock management}, volume = {12}, year = {2025}, }
• (2025). Direct ink writing of 3D-structured all-carbon electrodes with high electrical conductivity for (Vanadium) redox flow batteries. ADVS, 12(22), 2417641. (www)

  @article{ , abstract = {Redox flow batteries are attractive systems for large-scale energy storage due to their capability to uncouple energy and power but still need to make several improvements to reach full commercial scale. The need to search for better components, including electrode materials that allow the internal flow of electrolytes and have optimal electrochemical performance is a hot topic in the development of this kind of battery. The use of direct ink writing technology to engineer complex electrode materials both in the architecture and chemical composition opens a new field of research to optimize electrode performance. In this study, several formulations are prepared using graphite, multiwall carbon nanotubes, and two different Polyacrylonitrile (PAN)-based short carbon fibers. Furthermore, a graphitizable binder is added to the formulation to help consolidate the printed object into a highly conductive (3000–8000 Sm −1 ) and mechanically resistant carbon electrode after a moderate heat treatment (800 °C). The 3D electrodes are successfully tested in an all vanadium redox flow cell showing a competitive performance when compared to benchmark electrodes (graphite felts).}, archive = {J_ADVS}, author = {Pablo Rodríguez Lagar and Alejandro Concheso and Daniel Barreda and Zoraida González and Miguel A. Montes-Morán and J. Angel Menéndez and Clara Blanco and Ricardo Santamaría and Victoria G. Rocha}, doi = {10.1002/advs.202417641}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417641}, shortjournal = {Adv. Sci.}, title = {Direct ink writing of 3D-structured all-carbon electrodes with high electrical conductivity for (Vanadium) redox flow batteries}, volume = {12}, year = {2025}, }
• (2025). 3D printed sodiophilic reduced graphene Oxide/Diamane microlattice aerogel for enhanced sodium metal battery anodes. ADVS, 12(22), 2417638. (www)

  @article{ , abstract = {Sodium metal anode holds great potential for high energy density sodium batteries. However, its practical utilization is impeded by significant volume change and uncontrolled dendrite growth. To tackle these issues, a three-dimensional (3D) hierarchical porous sodiophilic reduced graphene oxide/diamane (rGO/diamane) microlattice aerogel is constructed by a direct ink writing (DIW) 3D printing (3DP) method. The molten Na is diffused into the rGO/diamane host to form Na@rGO/diamane anode, which can deliver an ultra-high capacity of 78.60 mAh cm −2 (1090.94 mAh g −1 ). Benefiting from uniform ion distribution and homogeneously distributed sodiophilic diamane enabled dendrite-free deposition morphology, the Na@rGO/diamane anodes exhibit a long cycle-life of over 7200 h at 1 mA cm −2 with 1 mAh cm −2 . Furthermore, the Na@rGO/diamane anode also enhances the long-term stability at an elevated operation temperature of 60 °C, sustaining a prolonged lifespan of 400 h at 1 mA cm −2 with 1 mAh cm −2 . Notably, when integrated with the Na 3 V 2 (PO 4 ) 3 @carbon (NVP@C) cathode and Na@rGO/diamane anode, the full cell delivers sustained longevity, maintaining a lifespan of over 2000 cycles with a capacity retention rate of 95.72%. This work sheds new insights into the application of diamane for the development of stable and high-performance sodium metal batteries.}, archive = {J_ADVS}, author = {Mengmeng Liu and Dezhi Kong and Ningning Chu and Gang Zhi and Hui Wang and Tingting Xu and Xinchang Wang and Xinjian Li and Zhuangfei Zhang and Hui Ying Yang and Ye Wang}, doi = {10.1002/advs.202417638}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417638}, shortjournal = {Adv. Sci.}, title = {3D printed sodiophilic reduced graphene Oxide/Diamane microlattice aerogel for enhanced sodium metal battery anodes}, volume = {12}, year = {2025}, }
• (2025). Wearable hyperspectral photoplethysmography allows continuous monitoring of exercise-induced hypertension. ADVS, 12(22), 2417625. (www)

  @article{ , abstract = {Continuous blood pressure (BP) monitoring is essential for cardiovascular health, yet current BP sensors face cuff-dependent limitations. Cuff-free alternatives still suffer from discomfort and discontinuous measurement. Here a wearable hyperspectral photoplethysmography (HS-PPG) is reported for continuous and nonconscious BP monitoring. The HS-PPG module integrates an ultrathin and high-resolution double-folded solid immersion grating microspectrometer (DFSIG-µSPEC) with a white light LED. DFSIG-µSPEC shows an average spectral resolution of 3.4 nm for 550–800 nm in the operational range. The HS-PPG module has a compact physical dimension of 8 mm × 16 mm × 24 mm, suitable for wrist-wearable configuration. The PPG waveforms contain 50 spectral bands, achieving precise measurement of arteriolar pulse transit time (aPTT). The diastolic and systolic BPs are precisely estimated with R-values of 0.92 and 0.96, and mean absolute differences (MAD) of 1.20 and 0.40 mmHg with the 2-element Windkessel model, respectively. Further, the BP is continuously measured with heart rate (HR) and respiratory exchange ratio (RER) with exercise-induced hypertension. Continuous monitoring of systolic blood pressure (SBP) exhibits immediate responses during hemodynamic changes, with the physiological parameters of SBP, HR, and RER during exercise and recovery. The wearable HS-PPG clearly supports the strong potential for high-fidelity continuous BP monitoring.}, archive = {J_ADVS}, author = {Jung-Woo Park and Jaehyeok Park and Jaehun Jeon and Seongok Chae and Gi Beom Kim and Geonhui Han and Hyung-Soon Park and Yong Jeong and Ki-Hun Jeong}, doi = {10.1002/advs.202417625}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417625}, shortjournal = {Adv. Sci.}, title = {Wearable hyperspectral photoplethysmography allows continuous monitoring of exercise-induced hypertension}, volume = {12}, year = {2025}, }
• (2025). Uncovering interfacial oxygen-bridged binuclear metal centers of heterogenized molecular catalyst for water electrolysis. ADVS, 12(22), 2417607. (www)

  @article{ , abstract = {The success of different heterogeneous strategies of organometallic catalysts has been demonstrated to achieve high selectivity and activity in photo/electrocatalysis. However, yielding their catalytic mechanisms at complex molecule-electrode and electrochemical interfaces remains a great challenge. Herein, shell-isolated nanoparticle-enhanced Raman spectroscopy is employed to elucidate the dynamic process, interfacial structure, and intermediates of copper hydroxide-2-2′ bipyridine on Au electrode ((bpy)Cu(OH) 2 /Au) during the oxygen evolution reaction (OER). Direct Raman molecular evidences reveal that the interfacial (bpy)Cu(OH) 2 oxidizes into Cu(III) and bridges to Au atoms via oxygenated species, forming (bpy)Cu(III)O 2 -Au with oxygen-bridged binuclear metal centers of Cu(III)-O-Au for the OER. As the potential further increases, Cu(III)-O-Au combines with surface hydroxyl groups (*OH) to form the important intermediate of Cu(III)-OOH-Au, which then turns into Cu(III)-OO-Au to release O 2 . Furthermore, in situ electrochemical impedance spectroscopy proves that the Cu(III)-O-Au has lower resistance and faster mass transport of hydroxy to enhance OER. Theoretical calculations reveal that the formation of Cu(III)-O-Au significantly modify the elementary reaction steps of the OER, resulting in a lower potential-determining step of ≈0.58 V than that of bare Au. This work provides new insights into the OER mechanism of immobilized-molecule catalysts for the development and application of renewable energy conversion devices.}, archive = {J_ADVS}, author = {Zhou Yu and Jian-Ping Li and Xian-Kun Xu and Zhong-Chen Ding and Xiao-Hui Peng and Yi-Jing Gao and Qiang Wan and Ju-Fang Zheng and Xiao-Shun Zhou and Ya-Hao Wang}, doi = {10.1002/advs.202417607}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417607}, shortjournal = {Adv. Sci.}, title = {Uncovering interfacial oxygen-bridged binuclear metal centers of heterogenized molecular catalyst for water electrolysis}, volume = {12}, year = {2025}, }
• (2025). Manipulation of oxygen tension in damaged regions via hypoxia-induced IPN hydrogel microspheres for intervertebral disc regeneration. ADVS, 12(22), 2417570. (www)

  @article{ , abstract = {Disruption of low oxygen tension homeostasis during intervertebral disc degeneration inhibits endogenous stem cell viability and function, posing a challenge for endogenous regeneration. Here, to achieve sustained hypoxia manipulation, constructed hypoxia-inducible interpenetrating polymer network (IPN) hydrogel microspheres (HIMS) are constructed by microfluidics to integrate the hypoxic system with a stabilizing network. The IPN is synthesized through a two-step polymerization process, consisting of rapid photo-crosslinked gelatin methacrylate anhydride (GM) polymer I and slow enzyme-crosslinked vanillin-grafted gelatin (GV) polymer II. The enzymatic reaction between GV and laccase is able to create a hypoxic microenvironment to modulate oxygen tension in situ within the injured region. HIMS can reduce microenvironmental oxygen tension by 1/3 and maintain a hypoxic microenvironment for up to 5 days, thereby activating the PI3K/AKT/HIF-1α signaling pathway in endogenous stem cells to promote differentiation into nucleus pulposus-like cells. Additionally, NSC-Exos are loaded onto HIMS to trigger endogenous progenitor/stem cell recruitment and migration. Both in vitro and in vivo assays demonstrate that NSC-Exos@HIMS facilitates stem cell recruitment, targets differentiation, and stimulates extracellular matrix synthesis. Overall, the microspheres established herein provide a novel strategy for manipulating oxygen tension and enhancing endogenous tissue regeneration in injured regions during intervertebral disc degeneration.}, archive = {J_ADVS}, author = {Xingdie Zhou and Zhendong Lv and Zehao Chen and Yiming Xu and Chao Lin and Li Liu and Hao Chen and Bing Niu and Wenguo Cui and Yuhui Zhang}, doi = {10.1002/advs.202417570}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417570}, shortjournal = {Adv. Sci.}, title = {Manipulation of oxygen tension in damaged regions via hypoxia-induced IPN hydrogel microspheres for intervertebral disc regeneration}, volume = {12}, year = {2025}, }
• (2025). Constructing high-performance inverted perovskite solar cells using chiral organic molecules. ADVS, 12(22), 2417550. (www)

  @article{ , abstract = {Chiral molecules have shown potential in passivating perovskite solar-cell interfaces and boosting charge transport and have drawn significant research interest. However, the specific passivation mechanisms of different chiral structures on perovskite films and their photoelectric effects require further investigation. In this study, chiral R -, S -, and rac -methylbenzylammonium chloride (MBACl) molecules are used to address interface defects. S -MBACl exhibits the strongest chelation and passivation effects. Kelvin probe force microscopy results show that S -MBACl increases the surface potential differences between dark and illuminated states by 227%, from 39.67 to 129.91 mV, and enhances electron–hole separation. Consequently, the power conversion efficiency (PCE) of S -MBACl-modified devices is 24.07%, which is 109% times that of the pure perovskite sample. The PCE of unencapsulated S -MBACl-modified perovskite solar cells remains at 89% of the initial value after aging at 25 °C for 2400 h in the N 2 atmosphere. This study provides valuable insights for future studies on chiral passivation molecules.}, archive = {J_ADVS}, author = {Zixuan Shang and Jinbao Han and Hongliang Dong and Mengxi Lv and Qianru Zhang and Zhiqiang Chen and Mingxing Wu and Jinjin Zhao}, doi = {10.1002/advs.202417550}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417550}, shortjournal = {Adv. Sci.}, title = {Constructing high-performance inverted perovskite solar cells using chiral organic molecules}, volume = {12}, year = {2025}, }
• (2025). Battery-free, stretchable, and autonomous smart packaging. ADVS, 12(22), 2417539. (www)

  @article{ , abstract = {In the food industry, innovative packaging solutions are increasingly important for reducing food waste and contributing to global sustainability efforts. However, current food packaging is generally passive and unable to adapt to changes in the food environment in real time. To address this, a battery-less and autonomous smart packaging system is developed that wirelessly powers closed-loop sensing and release of active compounds. This system integrates a gas sensor for real-time food monitoring, a Near-Field Communication (NFC) antenna, and a controlled release of active compounds to prevent quality deterioration in the complex food environment. The ability of the developed smart packaging system is demonstrated, to continuously monitor the freshness of fish products and to trigger the release of active compounds when the food starts to spoil. The system is able to extend the shelf-life of the food product up to 14 days, due to the controlled release of antioxidant and antibacterial compounds. The system can pave the way toward an Internet of Things solution that addresses protection, active prevention of food spoilage, and sustainability, facing all the current challenges of the food packaging industry.}, archive = {J_ADVS}, author = {Ali Douaki and Mukhtar Ahmed and Edoardo Longo and Giulia Windisch and Raheel Riaz and Sarwar Inam and Thi Nga Tran and Evie L. Papadopoulou and Athanassia Athanassiou and Emanuele Boselli and Luisa Petti and Paolo Lugli}, doi = {10.1002/advs.202417539}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417539}, shortjournal = {Adv. Sci.}, title = {Battery-free, stretchable, and autonomous smart packaging}, volume = {12}, year = {2025}, }
• (2025). Virome and experimental analysis reveal tryptophan-like dissolved organic matter contributes to the persistence of plant viruses in river water. ADVS, 12(22), 2417529. (www)

  @article{ , abstract = {Plant viruses are devastating plant pathogens, resulting in annual losses exceeding billions of dollars in global agriculture. Once outside their plant host and insect vectors, plant viruses encounter unfavorable environmental factors that can accelerate their decay. However, plant viruses have been observed to persist in aquatic environment. The reasons why many plant viruses remain stable and infective in aquatic environment for extended periods are still largely unknown. In this study, a virome approach is utilized to examine the presence of plant viruses in river water. The results indicated that tryptophan-like dissolved organic matter (Try-like DOM) may play a crucial role influencing the abundance of plant viruses in river water. Further experiments found that Try-like DOM can protect plant viruses under simulated natural conditions. This protective phenomenon is attributed to Try-like DOM adopting a “swimming firewall mode”, i.e., free Try-like DOM can act as a firewall to effectively absorb ultraviolet (UV) light, helping plant viruses avoid the harmful effects of UV radiation and free radicals. These findings offer new insights into the mechanisms underlying the persistence of plant viruses in aquatic environment, which would be helpful in developing strategies to control the spread of plant viruses.}, archive = {J_ADVS}, author = {Yujie Wang and Ming Chen and Liu Yang and Jun Ma and Jian Tang and Shengjun Wu and Chi He and J. Paul Chen}, doi = {10.1002/advs.202417529}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417529}, shortjournal = {Adv. Sci.}, title = {Virome and experimental analysis reveal tryptophan-like dissolved organic matter contributes to the persistence of plant viruses in river water}, volume = {12}, year = {2025}, }
• (2025). Constructing mn-co-fe ternary metal phosphides nanosheet arrays as bifunctional electrocatalysts for overall water splitting. ADVS, 12(22), 2417521. (www)

  @article{ , abstract = {Bifunctional electrocatalysts with high efficiency, stability, and distinguished performance have attracted more and more attention in the field of overall water splitting, while the composition and structure design are very essential for electrocatalysts with superb performance and low price. In this work, the heterostructure Mn-Co-Fe-P nanoarrays is in situ grown on nickel foam (NF) by simple hydrothermal method and phosphating method. The resultant Mn-Co-Fe-P catalyst has favorable electrocatalytic performance with the oxygen evolution reaction (OER) overpotential at 10 (100) mA cm −2 of 192 (279) mV and the Tafel slope of 43.75 mV dec −1 , the hydrogen evolution reaction (HER) overpotential at 10 (100) mA cm −2 of 98 (152) mV and the Tafel slope of 40.68 mV dec −1 , and the full voltage of 1.66 V at 100 mA cm −2 when applied to overall water splitting. The 3D heterostructure provides more active sites, and the in situ growth improves the stability and conductivity of the catalyst. This binder-free heterostructure electrocatalyst with excellent stability and catalytic performance is a promising bifunctional electrocatalyst candidate for overall water splitting.}, archive = {J_ADVS}, author = {Fan Wang and Zhen Pei and Zhou Xu and Tengteng Qin and Xin Ouyang and Dongyun Li and Yang Hou and Xingzhong Guo}, doi = {10.1002/advs.202417521}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417521}, shortjournal = {Adv. Sci.}, title = {Constructing mn-co-fe ternary metal phosphides nanosheet arrays as bifunctional electrocatalysts for overall water splitting}, volume = {12}, year = {2025}, }
• (2025). Decursin-loaded nanovesicles target macrophages driven by the pathological process of atherosclerosis. ADVS, 12(22), 2417489. (www)

  @article{ , abstract = {Atherosclerosis (AS) is a major pathological factor contributing to the mortality associated with ischemic heart disease and is driven primarily by macrophage-mediated lipid accumulation and inflammatory processes. Conventional cardiovascular pharmacotherapies address these pathological mechanisms but often show limited efficacy, highlighting the need for innovative agents capable of effectively reducing lipid accumulation and inflammation with minimal toxicity. In this study, decursin, a monomer derived from traditional Chinese medicine, is shown to inhibit both lipid accumulation and inflammatory responses in macrophages through direct interaction with protein kinase Cδ (PKCδ), resulting in low cytotoxicity in vitro and negligible toxicity in vivo. To address the short half-life of decursin, a targeted cascade drug delivery system (ALD@EM), which is specifically designed to target AS pathophysiology, is developed. This system employs ICAM-1 and VCAM-1 antibodies for plaque localization and incorporates low-density lipoproteins (LDLs) to facilitate chemotaxis to lesion sites, with an inner layer of apoptotic endothelial cell membranes to increase macrophage internalization and drug release. As a result, ALD@EM nanovesicles significantly increased the accumulation and therapeutic efficacy of decursin within plaques, substantially reducing lipid deposition and plaque inflammation, thereby offering a novel strategy for targeted AS treatment.}, archive = {J_ADVS}, author = {Hui Chen and Yifeng Zhang and Mirenuer Aikebaier and Yawei Du and Yan Liu and Qing Zha and Lan Zheng and Shuyao Shan and Yanping Wang and Jiawei Chen and Yiping Li and Ke Yang and Ying Yang and Wenguo Cui}, doi = {10.1002/advs.202417489}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417489}, shortjournal = {Adv. Sci.}, title = {Decursin-loaded nanovesicles target macrophages driven by the pathological process of atherosclerosis}, volume = {12}, year = {2025}, }
• (2025). Inhalable polymeric nanoparticle containing triphenylphosphanium bromide-modified sonosensitizer for enhanced therapy of acute bacterial pneumonia. ADVS, 12(22), 2417469. (www)

  @article{ , abstract = {Sonodynamic therapy (SDT) has good feasibility to deeply seated infections, but SDT alone is insufficient being highly effective against multidrug-resistant (MDR) bacteria. SDT combined with triphenylphosphanium bromide (P + Ph 3 Br − ) is expected to solve this problem. This work develops a pseudo-conjugated polymer P FCPS-P containing cationic P + Ph 3 Br − -modified sonosensitizer FCPS (FCPS-P) and ROS-sensitive thioketal bonds. P FCPS-P is assembled with DSPE-mPEG 2000 to generate nanoparticle NP FCPS-P . FCPS has SDT effect and generates ROS under ultrasound (US) stimulation. ROS triggers the degradation of NP FCPS-P and release of FCPS-P, endowing highly favored biosafety. FCPS-P targets to bacterial surface through electrostatic interaction and achieves bacterial killing under a synergistic action of SDT and P + Ph 3 Br − . In vitro, NP FCPS-P +US gives >90% inhibition rates against MDR ESKAPE pathogens, moreover, it causes bacterial metabolic disorders including inhibited nucleic acid synthesis, disordered energy metabolism, excessive oxidative stress, and suppressed biofilm formation and virulence. In mice, NP FCPS-P +US exhibits a 99.3% bactericidal rate in Pseudomonas aeruginosa -induced sublethal pneumonia and renders a 90% animal survival rate in lethal pneumonia, and additionally immunological staining and transcriptomics analyses reveal that NP FCPS-P +US induces inhibited inflammatory response and accelerated lung injury repair. Taken together, NP FCPS-P +US is a promising antibiotics-alternative strategy for treating deeply seated bacterial infections.}, archive = {J_ADVS}, author = {Lin Wang and Fangzhou Chen and Nier Wu and Lingfei Hu and Haihua Xiao and Hanchen Zhang and Dongsheng Zhou}, doi = {10.1002/advs.202417469}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417469}, shortjournal = {Adv. Sci.}, title = {Inhalable polymeric nanoparticle containing triphenylphosphanium bromide-modified sonosensitizer for enhanced therapy of acute bacterial pneumonia}, volume = {12}, year = {2025}, }
• (2025). Bioinspired adaptive neuron enabled by self-powered optoelectronic memristor and threshold switching memory for neuromorphic visual system. ADVS, 12(22), 2417461. (www)

  @article{ , abstract = {Visual adaptation allows organisms to effectively analyze visual information in varying light conditions by autonomously adjusting photosensitivity, which is essential for the visual system to perform accurate perception in complex environments. In order to realistically implement the functionality of the visual system, the exploration of bioinspired electronics with adaptive capability is highly desired. Herein, a self-powered optoelectronic memristor based on ZnO/WO x heterojunction is developed, which can exhibit the visual adaptation functions of desensitization and Weber's law. These functions are achieved through the coupling of the photovoltaic effect with electron trapping in the space charge region of the heterojunction. Furthermore, a bioinspired visual adaptive neuron has been constructed, comprising an optoelectronic memristor and a NbO x -based threshold switching memory, capable of directly converting constant light stimuli into dynamic spike trains. Finally, the adaptive image preprocessing is realized, which promotes the improvement of the object recognition accuracy during the overexposed image recognition process. This study offers a novel approach to developing biologically plausible visual adaptation, fostering the future progress of dynamic neuromorphic visual systems.}, archive = {J_ADVS}, author = {Yankun Cheng and Junchao Zhang and Ya Lin and Zhongqiang Wang and Xuanyu Shan and Ye Tao and Xiaoning Zhao and Haiyang Xu and Yichun Liu}, doi = {10.1002/advs.202417461}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417461}, shortjournal = {Adv. Sci.}, title = {Bioinspired adaptive neuron enabled by self-powered optoelectronic memristor and threshold switching memory for neuromorphic visual system}, volume = {12}, year = {2025}, }
• (2025). PRMT1-mediated SWI/SNF complex recruitment via SMARCC1 drives IGF2BP2 transcription to enhance carboplatin resistance in head and neck squamous cell carcinoma. ADVS, 12(22), 2417460. (www)

  @article{ , abstract = {Head and neck squamous cell carcinoma (HNSCC) is a malignancy with poor prognosis and chemotherapy resistance. Here, protein arginine methyltransferase 1 (PRMT1) is identified as a key driver of carboplatin (CBP) resistance in HNSCC. Analyses of clinical samples, cell lines, patient-derived organoids, and xenograft models reveal that PRMT1 promotes tumor growth and CBP resistance through a novel, methyltransferase-independent mechanism. Conditional PRMT1 knockout suppresses tumorigenesis and enhances CBP sensitivity in vivo, highlighting its essential role in HNSCC progression. Mechanistically, PRMT1 recruits the SWI/SNF chromatin remodeling complex via direct interaction with SMARCC1, leading to the transcriptional activation of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), which enhances CBP resistance and tumor growth. Notably, this function is independent of PRMT1's enzymatic activity, distinguishing it from its well-established roles in arginine methylation. Furthermore, pre-B-cell leukemia homeobox 2 (PBX2) is identified as an upstream transcriptional activator that binds the PRMT1 promoter, driving its overexpression and reinforcing this oncogenic network. Clinically, high PBX2, PRMT1, SMARCC1, and IGF2BP2 expression correlates with malignant progression and poor prognosis in HNSCC patients. This study uncovers a previously unrecognized non-catalytic function of PRMT1 and highlights the PBX2-PRMT1-SWI/SNF-IGF2BP2 axis as a potential therapeutic target for overcoming CBP resistance in HNSCC.}, archive = {J_ADVS}, author = {Shixian Liu and Wentao Zhang and Weiwei Liu and Zhao Ding and Ruijing Zhang and Yuefeng Han and Zihao Niu and Mengdie Zhang and Hui Li and Dapeng Li and Zixi Wang and Jie Peng and Yu Wu and Yanxun Han and Zihui Xie and Jing Wu and Liang Qin and Zhongdong Hu and Xu Chen and Yunlong Hu and Yehai Liu and Shiyin Ma and Xiaojun Zha}, doi = {10.1002/advs.202417460}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417460}, shortjournal = {Adv. Sci.}, title = {PRMT1-mediated SWI/SNF complex recruitment via SMARCC1 drives IGF2BP2 transcription to enhance carboplatin resistance in head and neck squamous cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). High proton conductivity in xCuO/(1-x)CeO2 electrolytes induced by CuO self-nucleation and electron-ion coupling. ADVS, 12(22), 2417421. (www)

  @article{ , abstract = {Operating within the 300–500 °C range, low-temperature solid oxide fuel cells (LT-SOFCs) enable efficient and sustainable energy conversion, addressing the limitations of conventional high-temperature SOFCs. However, achieving >0.1 S cm −1 ionic conductivity in electrolytes remains challenging. Here, a novel approach utilizing CuO self-nucleation and electron-ion (E-I) coupling in x CuO/(1- x ) CeO 2 (CCO) semiconductor ionic membranes ( x = 0–0.4) is presented. At the optimal 0.2CuO/0.8CeO 2 composition, ionic conductivity exceeds 0.15 S cm −1 , driven by E-I coupling at the CuO/CeO 2 heterojunction. This coupling creates a built-in electric field (BIEF) via interfacial charge transfer, facilitating ion transport by lowering the activation energy for ion migration. The dual-conduction pathway enabled by E-I coupling not only facilitates electronic transfer and ionic transport but also optimizes charge transfer kinetics, achieving exceptional power densities of 750–900 mW cm −2 at 500–550 °C and 78 mW cm −2 at 300 °C. Density functional theory (DFT) calculations further validate the role of Cu 2+ and Ce 4+ valence states in generating interfacial charge transfer and enhancing ionic mobility. This innovative approach positions CuO/CeO 2 as a state-of-the-art electrolyte, building the critical conductivity-performance gap in LT-SOFCs. This study pioneers LT-SOFC innovation by leveraging E-I coupling and electrode–electrolyte synergy, unlocking superior ion transport and practical applicability.}, archive = {J_ADVS}, author = {Muhammad Shahid Sharif and Sajid Rauf and Zuhra Tayyab and Muhammad Ahsan Masood and Yibin Tian and Muhammad Ali Kamran Yousaf Shah and Abdullah N. Alodhayb and Rizwan Raza and Bin Zhu}, doi = {10.1002/advs.202417421}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417421}, shortjournal = {Adv. Sci.}, title = {High proton conductivity in xCuO/(1-x)CeO2 electrolytes induced by CuO self-nucleation and electron-ion coupling}, volume = {12}, year = {2025}, }
• (2025). Ethylene-activated e3 ubiquitin ligase MdEAEL1 promotes apple fruit softening by facilitating the dissociation of transcriptional repressor complexes. ADVS, 12(22), 2417393. (www)

  @article{ , abstract = {Fruit of most apple varieties soften after harvest, and although the hormone ethylene is known to induce softening, the associated pathway is not well resolved. In this study, it is determined that MdEAEL1 (Ethylene-activated E3 ubiquitin Like 1) is specifically expressed during apple fruit postharvest storage, activated by ethylene, and interacts with the transcription factor MdZFP3 (zinc finger protein3). MdZFP3 is found to rely on an EAR (ethylene-responsive element binding factor-associated amphiphilic repression) motif to form a transcriptional repression complex with MdTPL4 (TOPLESS4)-MdHDA19 (histone deacetylase19), thereby downregulating the histone acetylation levels of the promoters of a range of cell wall degradation-related genes and inhibiting their transcription. MdEAEL1 ubiquitinates and degrades MdZFP3, leading to the disassembly of the MdZFP3-MdTPL4-MdHDA19 transcriptional repression complex. This process promotes the transcription of cell wall degradation-related genes, resulting in fruit softening during storage. Furthermore, the disassembly of the MdZFP3-MdTPL4-MdHDA19 transcriptional repression complex, mediated by MdEAEL1, upregulates the transcription of MdEAEL1 itself, creating a feedback loop that further promotes softening. This study elucidates the interplay between post-translational modifications of a transcription factor and its epigenetic modification to regulate fruit softening, and highlights the complexity of ethylene-induced softening.}, archive = {J_ADVS}, author = {Tong Li and Li Liu and Guangxin Yang and Yingcong Cai and Yingda Wang and Bowen Sun and Le Sun and Weiting Liu and Aide Wang}, doi = {10.1002/advs.202417393}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417393}, shortjournal = {Adv. Sci.}, title = {Ethylene-activated e3 ubiquitin ligase MdEAEL1 promotes apple fruit softening by facilitating the dissociation of transcriptional repressor complexes}, volume = {12}, year = {2025}, }
• (2025). Photo-biomodulation of the hippocampus using near-infrared laser to enhance cognitive function in mice. ADVS, 12(22), 2417380. (www)

  @article{ , abstract = {Photo-biomodulation (PBM) with near-infrared (NIR) laser emerges as a promising noninvasive therapy for enhancing cognitive function. Here the effects of PBM, equipped with an 808 nm NIR laser, on cognitive function are investigated when used to irradiate hippocampi of mice. NIR irradiation once a day for 5 min per day for 5 consecutive days significantly improves the learning and memory performance of naïve mice assessed with the Barnes and Y maze tests. PBM also significantly attenuates cognitive dysfunction following anesthesia and surgery, and lipopolysaccharide challenge, respectively. Cognitive enhancements are associated with increased neuronal oscillations and enhanced theta–gamma coupling in the hippocampal dentate gyrus (DG) during cognitive processing. High neuronal activation in the DG is evidenced by increased c-Fos expression and calcium signal intensity. The improvements are also associated with high-density cells in the DG together with facilitating local energy deposition and neuronal activation. NIR-laser-activated axonogenesis and oxidative phosphorylation-related genes assessed with single-cell RNA sequencing were seen in the DG. These findings suggest that PBM very likely holds great potential as a noninvasive therapy for cognitive dysfunction.}, archive = {J_ADVS}, author = {Wei-Tong Pan and Han-Wen Gu and Yan-Bo Zhou and Sophie Ma and Daqing Ma and Pan-Miao Liu and Jian-Jun Yang}, doi = {10.1002/advs.202417380}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417380}, shortjournal = {Adv. Sci.}, title = {Photo-biomodulation of the hippocampus using near-infrared laser to enhance cognitive function in mice}, volume = {12}, year = {2025}, }
• (2025). Targeting PFKFB4 biomimetic codelivery system synergistically enhances ferroptosis to suppress small cell lung cancer and augments the efficacy of anti-PD-l1 immunotherapy. ADVS, 12(22), 2417374. (www)

  @article{ , abstract = {Small cell lung cancer (SCLC) is an extremely aggressive and highly malignant type of lung cancer that frequently develops resistance and recurrence following initial treatment. Paclitaxel (PTX) is a second-line therapeutic option for SCLC patients with resistance to first-line treatment. However, its clinical application is limited due to suboptimal efficacy and the risk of hypersensitivity reactions. To address these challenges, a novel therapeutic strategy employing a cationic liposome-based biomimetic drug co-delivery system, siPFKFB4/PRL PTX @RBCM-cRGD, which simultaneously delivers paclitaxel and PFKFB4-targeting small interfering RNA (siRNA) to SCLC cells and tissues is proposed. These findings demonstrate that this co-delivery system can induce ferroptosis in SCLC cells, thereby enhancing their sensitivity to paclitaxel. Moreover, It promotes the infiltration of immune cells and the secretion of cytokines within the SCLC immune microenvironment, effectively activating anti-tumor immunity. When combined with anti-PD-L1 antibodies, it further potentiates anti-tumor immune responses. These results suggest that the biomimetic codelivery system not only induces ferroptosis to enhance paclitaxel efficacy but also reprograms the SCLC immune microenvironment, thereby potentiating the effects of anti-PD-L1 immunotherapy and providing a promising new therapeutic strategy for SCLC.}, archive = {J_ADVS}, author = {Xiang Liu and Jingjun He and Haoxuan Ying and Cuiying Chen and Chongyang Zheng and Peng Luo and Weiliang Zhu and Ting Wei and Bufu Tang and Jian Zhang}, doi = {10.1002/advs.202417374}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417374}, shortjournal = {Adv. Sci.}, title = {Targeting PFKFB4 biomimetic codelivery system synergistically enhances ferroptosis to suppress small cell lung cancer and augments the efficacy of anti-PD-l1 immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Camouflaged nanozymes with oxidation-promoting activities triggering ferroptosis for radio-immunotherapy. ADVS, 12(22), 2417370. (www)

  @article{ , abstract = {Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop a cancer cell membrane (CM) - coated nanozyme system (MPPC@CM), specifically designed for radioimmunotherapy to address this issue. This innovative system involves the in situ reduction of platinum and palladium on mesoporous silica nanospheres, followed by functionalization with cinnamaldehyde via surface grafting. The CM coating endows the nanozyme with enhanced tumor-specific targeting capability due to its homing properties. Upon uptake by tumor cells, MPPC@CM catalytically generates O 2 from H 2 O 2 , mitigating the hypoxic tumor microenvironment and reducing radioresistance.     The intracellular glutathione depletion mediated by Michael addition reactions concurrently disrupts endogenous antioxidant defenses against reactive oxygen species (ROS). This redox imbalance is synergistically amplified through nanozyme-mediated catalytic activities including both peroxidase-like and oxidase-like functions. The resultant massive ROS accumulation establishes a self-reinforcing oxidative cascade that ultimately induces functional inactivation of glutathione peroxidase 4. The immunosuppressive environment is remodeled by this disturbance in redox balance, which accelerates ferroptosis and increases CD8 + T-cell infiltration and dendritic cell maturation. Overall, this cell membrane-camouflaged nanozyme holds significant potential to enhance the efficacy of radioimmunotherapy.}, archive = {J_ADVS}, author = {Kun Qiao and Yongbiao Huang and Shipeng Ning and Meng Lyu and Jieqiong Xie and Shiyuan Zhang and Xiuxin Lu and Yuan Yu and Wei Jiang and Bo Liu and Kelong Fan and Tong Liu}, doi = {10.1002/advs.202417370}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417370}, shortjournal = {Adv. Sci.}, title = {Camouflaged nanozymes with oxidation-promoting activities triggering ferroptosis for radio-immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Magnetic-guided delivery of antisense oligonucleotides for targeted transduction in multiple retinal explant and organoid models. ADVS, 12(22), 2417363. (www)

  @article{ , abstract = {Antisense oligonucleotide (ASO) therapy holds promise in gene therapy but faces challenges due to poor delivery efficiency and limited evaluation models. This investigation employs magnetic nanoparticles (MNPs) to augment the delivery efficiency of ASOs. It assesses their distribution and therapeutic efficacy across various models, including retinal explants from mice and macaques or human retinal and inner ear organoids. Retinal explants from both mice and monkeys are methodically arranged to expose the ganglion cell layer (GCL) or the photoreceptor layer (PL). MNPs markedly enhanced the penetration and targeting of ASOs, resulting in a 60% accumulation in the GCL or 72% in the photoreceptors. Furthermore, an in vitro biomimetic model of the neuroretina-RPE/choroid-sclera complex is developed to examine ASO distribution under dynamic flow conditions. Moreover, the utilization of MNP-assisted ASO-Cy3 markedly enhanced transfection efficiency within human retinal and inner ear organoids, resulting in an increase in positively transfected cells to 60% and 70%, respectively. Here, for the first time, an MNP-explant-organoid platform is carried out for the promotion of ASO transfection efficiency, therapeutic screening and targeted delivery. This development paves the way for investigating novel gene therapy strategies targeting retinal diseases.}, archive = {J_ADVS}, author = {Xiuhong Ye and Sihui Chen and Wei Xiong and Fan Wang and Hon Fai Chan and Haocheng Lai and Xiangyu Guo and Tingting Yang and Shuhao Shen and Hang Chen and Wenxuan Wang and Guei-Sheung Liu and Yonglong Guo and Jiansu Chen}, doi = {10.1002/advs.202417363}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417363}, shortjournal = {Adv. Sci.}, title = {Magnetic-guided delivery of antisense oligonucleotides for targeted transduction in multiple retinal explant and organoid models}, volume = {12}, year = {2025}, }
• (2025). Catalyst-free direct hydrocarbonation of terminal alkynes toward E-alkene substituted stabilized sulfoxonium ylides. ADVS, 12(22), 2417362. (www)

  @article{ , abstract = {Amide and alkene moieties are frequently found in natural products and are privileged structures in pharmaceuticals and agrochemicals. Moreover, vinyl sulfoxonium ylide can be converted into a broad range of high-value compounds, thus they have been widely employed in organic synthesis. However, the synthesis of alkene-substituted amide-sulfoxonium ylides via intermolecular hydrocarbonation of alkynes remains underexplored. This study describes the development of a high-throughput approach to provide diverse functionalized E -alkene substituted (hetero)amide-sulfoxonium ylides. The reaction occurs under mild metal-free conditions, employing amide-sulfoxonium ylides as highly effective nucleophiles, which participate in Michael addition reactions with various substituted alkynes, such as esters, thioesters, ketones, amides, and sulfones. This low-cost, operationally simple approach has a broad substrate scope, high functional group compatibility, and excellent regio- and stereoselectivity, making it suitable for the transformation of structurally complex molecules. Furthermore, the obtained stabilized sulfoxonium ylide products are directly useful for the synthesis of diverse valuable 1,5-dicarbonyl and thiabenzene 1-oxide compounds.}, archive = {J_ADVS}, author = {Haiting Wu and Yougen Xu and An Lin and Jingyuan Liu and Huanjun Chen and Shimin Xie and Lebin Su}, doi = {10.1002/advs.202417362}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417362}, shortjournal = {Adv. Sci.}, title = {Catalyst-free direct hydrocarbonation of terminal alkynes toward E-alkene substituted stabilized sulfoxonium ylides}, volume = {12}, year = {2025}, }
• (2025). METTL14-induced M6A methylation increases g6pc biosynthesis, hepatic glucose production and metabolic disorders in obesity. ADVS, 12(22), 2417355. (www)

  @article{ , abstract = {METTL14 dimerizes with METTL3 to install N6-methyladenosine (m 6 A) on mRNA (m 6 A writers). Subsequently, m 6 A readers bind to m 6 A-marked RNA to influence its metabolism. RNA m 6 A emerges to critically regulate multiple intracellular processes; however, there is a gap in our understanding of m 6 A in liver metabolism. Glucose-6-phosphatase catalytic subunit (G6pc) mediates hepatic glucose production (HGP) and serves as the gatekeeper for glycogenolysis and gluconeogenesis; however, G6pc regulation is not fully understood. Here, METTL14 is identified as a posttranscriptional regulator of G6pc. Liver METTL14, METTL3, and m 6 A-methylated G6pc mRNA are upregulated in mice with diet-induced obesity. Deletion of Mettl14 decreases, whereas overexpression of METTL14 increases, G6pc mRNA m 6 A in hepatocytes in vitro and in vivo. Five m 6 A sites are identified, and disruption of them ( G6pc Δ 5A ) blocks METTL14-induced m 6 A methylation of G6pc Δ 5A mRNA. METTL14 increases both stability and translation of G6pc but not G6pc Δ 5A mRNA. YTHDF1 and YTHDF3 but not YTHDF2 (m 6 A readers) bind to m 6 A-marked G6pc mRNA to increase its synthesis. Deletion of hepatic Mettl14 decreases gluconeogenesis in primary hepatocytes, liver slices, and mice. Hepatocyte-specific restoration of G6pc reverses defective HGP in Mettl14 knockout mice. These results unveil a METTL14/ G6pc mRNA m 6 A/G6pc biosynthesis/HGP axis governing glucose metabolism in health and metabolic disease.}, archive = {J_ADVS}, author = {Qiantao Zheng and Xiao Zhong and Qianqian Kang and Zhiguo Zhang and Decheng Ren and Yong Liu and Liangyou Rui}, doi = {10.1002/advs.202417355}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417355}, shortjournal = {Adv. Sci.}, title = {METTL14-induced M6A methylation increases g6pc biosynthesis, hepatic glucose production and metabolic disorders in obesity}, volume = {12}, year = {2025}, }
• (2025). 2D programmable photodetectors based on WSe2/h-BN/Graphene heterojunctions. ADVS, 12(22), 2417300. (www)

  @article{ , abstract = {Programmable photovoltaic photodetectors based on 2D materials can modulate optical and electronic signals in parallel, making them particularly well-suited for optoelectronic hybrid dual-channel communication. This work presents a programmable non-volatile bipolar semi-floating gate photovoltaic photodetector (SFG-PD) constructed using tungsten diselenide (WSe 2 ), hexagonal boron nitride (h-BN), and graphene (Gra). By controlling the voltage pulses applied to the control gate, the device generates opposing built-in electric field junctions (p + -p and n-p junctions), enabling reversible switching between positive and negative light responses with a rapid response time of up to 2.02 µs. Moreover, the application of this device is demonstrated in dual-channel optoelectronic hybrid communication, offering a practical solution for achieving high-speed, large-capacity, low-loss, and secure multi-channel communication.}, archive = {J_ADVS}, author = {Zhihao Wang and Jialing Jian and Zhengjin Weng and Qianqian Wu and Jian Li and Xingyu Zhou and Wei Kong and Xiang Xu and Liangliang Lin and Xiaofeng Gu and Peng Xiao and Haiyan Nan and Shaoqing Xiao}, doi = {10.1002/advs.202417300}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417300}, shortjournal = {Adv. Sci.}, title = {2D programmable photodetectors based on WSe2/h-BN/Graphene heterojunctions}, volume = {12}, year = {2025}, }
• (2025). Aqueous two-phase submicron droplets catalyze DNA nanostructure assembly for confined fluorescent biosensing. ADVS, 12(22), 2417287. (www)

  @article{ , abstract = {Membraneless organelles (MLOs) are fundamental to cellular organization, enabling biochemical processes by concentrating biomolecules and regulating reactions within confined environments. While micrometer-scale synthetic droplets are extensively studied as models of MLOs, submicron droplets remain largely unexplored despite their potential to uniquely regulate biomolecular processes. Here, submicron droplets are generated by a polyethylene glycol (PEG)/dextran aqueous two-phase system (ATPS) as a model to investigate their effect on DNA assembly in crowded environments. The findings reveal that submicron droplets exhibit distinct advantages over microdroplets by acting as submicron catalytic centers that concentrate DNA and accelerate assembly kinetics. This enhancement is driven by a cooperative mechanism wherein global crowding from PEG induces an excluded volume effect, while local crowding from dextran provides weak but nonspecific interactions with DNA. By exploiting both the confinement and phase properties of submicron droplets, a rapid and sensitive assay is developed for miRNA detection using confined fluorescent readouts. These findings highlight the unique ability of submicron droplets to amplify biomolecular assembly processes, provide new insights into the interplay between global and local crowding effects in cellular-like environments, and present a platform for biomarker detection and visualization.}, archive = {J_ADVS}, author = {Xiaoman Duan and Siyi Duan and Zhaoyu Han and Haoyue Lv and Haozhen Yu and Biwu Liu}, doi = {10.1002/advs.202417287}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417287}, shortjournal = {Adv. Sci.}, title = {Aqueous two-phase submicron droplets catalyze DNA nanostructure assembly for confined fluorescent biosensing}, volume = {12}, year = {2025}, }
• (2025). Engineered probiotics mitigate gut barrier dysfunction induced by nanoplastics. ADVS, 12(22), 2417283. (www)

  @article{ , abstract = {Micro- and nanoplastics, particularly those derived from food-contact materials like polyethylene terephthalate (PET), can damage gut barriers, making the gastrointestinal system more vulnerable to inflammation and infections. Here, a probiotic-based drug delivery system (EcN T @L) is devised to mitigate nanoplastics-induced gut barrier dysfunction by modulating gut immunity and microbiota. Escherichia coli Nissle 1917 (EcN) is genetically engineered to produce transforming growth factor-β (TGF-β) and then modified with an Eudragit L100-55 coating. This engineered probiotic acts as an in vivo “drug factory”, exerting anti-inflammatory and immune-regulatory effects, with improved retention and bioavailability in the gastrointestinal tract. EcN T @L effectively protects Caco-2 cells from inflammation and infections induced by nano PET, primarily by activating the NF-κB signaling pathway. Besides, EcN T @L demonstrates superior in vivo therapeutic efficacy in treating gastrointestinal infection caused by the combined presence of nano PET and Salmonella , outperforming commercial antibiotics due to its ability to modulate immune responses and gut microbiota. This study highlights the potential of probiotic-based drug delivery systems in addressing nanoplastics-induced gut dysfunctions, offering a promising strategy for mitigating the environmental impact of micro- and nanoplastics.}, archive = {J_ADVS}, author = {Wenxin Chen and Qiyan Guo and Hong Li and Xue Chi and Xiang Ma and Yanqiong Tang and Quanfeng Liang and Zhu Liu and Yong Liu and Juanjuan Li}, doi = {10.1002/advs.202417283}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417283}, shortjournal = {Adv. Sci.}, title = {Engineered probiotics mitigate gut barrier dysfunction induced by nanoplastics}, volume = {12}, year = {2025}, }
• (2025). Bioorthogonal reaction of o-quinone with furan-2(3H)-one for site-selective tyrosine conjugation and construction of bispecific antibody complexes. ADVS, 12(22), 2417260. (www)

  @article{ , abstract = {Bioorthogonal reactions enable the chemical conjugation of functional moieties to native proteins and empower the development of new diagnostic tools and therapeutics. Through site-selective reactions, therapeutic molecules can be conjugated with antibodies in a stoichiometry- and site-controlled manner. Here, a one-pot chemoenzymatic reaction is reported that preferentially modifies a terminal tyrosine of recombinant proteins, or tyrosine 296 in the Fc domain of selected human antibodies. This reaction combines tyrosinase-catalyzed oxidation of phenol to o -quinone, the bioorthogonal addition reaction of o -quinone with an azide-containing furan-2( 3H )-one ( FuA ) moiety, and the subsequent azide click reactions. To this surprise, experimental evidence indicates that the o -quinone− FuA reaction proceeds through nucleophilic addition instead of the cycloaddition pathway. This reaction enables site-selective modification of therapeutic human antibodies, including atezolizumab, trastuzumab, daratumumab, and cetuximab. Monofunctionalized antibody conjugates and DNA-templated bispecific antibody complexes (DNA-bsAbC) are thus constructed in a modular way. DNA-bsAbC acts as a bispecific engager to mediate the interaction between immune cells and cancer cells, resulting in antibody-dependent cellular cytotoxicity (ADCC) toward cancer cells. Taken together, here a bioorthogonal reaction is reported for site-selective tyrosine conjugation in recombinant proteins and human antibodies and showcase its application in constructing antibody conjugates for potential applications in immunotherapies.}, archive = {J_ADVS}, author = {Hongfei Chen and Zhiyi Xu and Yishu Bao and Farshad Shiri and Dingdong Yuan and Yuke Hu and Biquan Li and Bin Zeng and Xiaojing Li and Hao Kong and Zikang Wang and Wilson Chun-Yu Lau and Zhenyang Lin and Jiang Xia}, doi = {10.1002/advs.202417260}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417260}, shortjournal = {Adv. Sci.}, title = {Bioorthogonal reaction of o-quinone with furan-2(3H)-one for site-selective tyrosine conjugation and construction of bispecific antibody complexes}, volume = {12}, year = {2025}, }
• (2025). High-throughput fluorescence screening enables globally consistent identification of ABA signaling modulators. ADVS, 12(22), 2417212. (www)

  @article{ , abstract = {Frequent exposure to environmental stresses can potentially reduce plant yield by up to 60%. The regulation of abscisic acid (ABA) signaling, especially its core receptors, is crucial for the adaptation of plants to environmental stress. However, efficient identification of ABA-signaling modulators remains a challenge. Here, a global high-throughput fluorescence screening (GhitFluors) platform is established to efficiently identify ABA signaling modulators. The GhitFluors platform yields a similar tendency for binding affinity to that determined by classical methods. Diopyridin is effectively identified, a regulator with strong binding affinity to Pyrabactin Resistance 1 (PYR1), and more than 80% inhibitory activity against HAB1, which is equivalent to ABA. Additionally, it can also effectively mitigate the adverse effects of drought on plants. The findings promise the start of a new era for achieving high-efficiency identification ABA signaling modulators.}, archive = {J_ADVS}, author = {Yang-Yang Gao and Chang-Xin Yang and Hong Wu and Jian-Hong Li and Ting Wen and Wei Wang and Zhi-Zheng Wang and Hui-Min Chen and Rong-Jie Pei and Zhi-You Huang and Yu-Guo Zheng and Guang-Fu Yang and Xiang-Yang Li and Ge-Fei Hao}, doi = {10.1002/advs.202417212}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417212}, shortjournal = {Adv. Sci.}, title = {High-throughput fluorescence screening enables globally consistent identification of ABA signaling modulators}, volume = {12}, year = {2025}, }
• (2025). Ultrasound-responsive 4D bioscaffold for synergistic sonopiezoelectric-gaseous osteosarcoma therapy and enhanced bone regeneration. ADVS, 12(22), 2417208. (www)

  @article{ , abstract = {Various antitumor strategies have emerged to address the escalating need for effective tumor eradication. However, achieving precise and spatiotemporally controlled dynamic therapies remains promising yet challenging. Sonopiezoelectric nanotherapy eliminates tumor cells by generating reactive oxygen species (ROS) through ultrasound stimulation, enabling spatiotemporal control and ensuring safety during deep tissue penetration. In this study, a hybrid bioscaffold incorporating few-layer black phosphorus (BP) and nitric oxide (NO) donors are rationally designed and engineered for sonopiezoelectric-gaseous synergistic therapy. This ultrasound-responsive system provides a stepwise countermeasure against tumor invasion in bone tissues. Ultrasonic vibration induces mechanical strain in BP nanosheets, leading to piezoelectric polarization and subsequent ROS generation. Moreover, ultrasound-triggered NO burst release from the donors enables spatiotemporally controlled gas therapy. The synergistic effects of sonopiezoelectric therapy and ultrasound-excited gas therapy enhance tumor eradication, effectively inhibiting tumor proliferation and metastasis while minimizing off-target cytotoxicity. Additionally, the biomineralization capability of degradable BP and proangiogenic effects of low-concentration NO establish the hybrid bioscaffold as a bioactive platform that facilitates subsequent bone regeneration. The development of this 4D multifunctional therapeutic platform, characterized by superior sonopiezoelectric efficacy, controlled NO release, and stimulatory effects on tissue regeneration, offers new insights into the comprehensive treatment of invasive bone tumors.}, archive = {J_ADVS}, author = {Haoyu Fang and Daoyu Zhu and Yixuan Chen and Changqing Zhang and Gan Li and Qihang Fang and Meiqi Chang and Yu Chen and Youshui Gao}, doi = {10.1002/advs.202417208}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417208}, shortjournal = {Adv. Sci.}, title = {Ultrasound-responsive 4D bioscaffold for synergistic sonopiezoelectric-gaseous osteosarcoma therapy and enhanced bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Enhanced the trans-cleavage activity of CRISPR-cas12a using metal-organic frameworks as stimulants for efficient electrochemical sensing of circulating tumor DNA. ADVS, 12(22), 2417206. (www)

  @article{ , abstract = {Continued development of clustered regularly interspaced short palindromic repeats (CRISPR)-powered biosensing system on the electrochemical interface is vital for accurate and timely diagnosis in clinical practice. Herein, an electrochemical biosensor based on manganese metal-organic frameworks (MOFs)-enhanced CRISPR (MME-CRISPR) is proposed that enables the efficient detection of circulating tumor DNA (ctDNA). In this design, customized enzyme stimulants (Mn 2+ ) are co-assembled with Cas12a/crRNA to form enzyme-MOF composites, which can be released quickly under mild conditions. The MOFs-induced proximity effect can continuously provide adequate Mn 2+ to sufficiently interact with Cas12a/crRNA during the release process, enhancing the trans-cleavage activity of complex available for biosensor construction. The MOFs-based enzyme biocomposites also afford efficient protection against various external stimulus. It is demonstrated that the developed biosensor can achieve ultrasensitive detection of epidermal growth factor receptor L858R mutation in ctDNA with a low detection limit of 0.28 f m without pre-amplification. Furthermore, the engineered mismatch crRNA enables the biosensor based on MME-CRISPR to detect single nucleotide variant with a high signal-to-noise ratio. More importantly, it has been successfully used to detect the targets in clinical practice, requiring low-dose samples and a short time. This strategy is believed to shed new light on the applications of cancer diagnosis, treatment, and surveillance.}, archive = {J_ADVS}, author = {Shuai Wu and Yincheng Liu and Tianyu Zeng and Tianci Zhou and Yanting Sun and Ying Deng and Juan Zhang and Genxi Li and Yongmei Yin}, doi = {10.1002/advs.202417206}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417206}, shortjournal = {Adv. Sci.}, title = {Enhanced the trans-cleavage activity of CRISPR-cas12a using metal-organic frameworks as stimulants for efficient electrochemical sensing of circulating tumor DNA}, volume = {12}, year = {2025}, }
• (2025). Covalently interlocked Electrode–Electrolyte interface for high-energy-density quasi-solid-state lithium-ion batteries. ADVS, 12(22), 2417143. (www)

  @article{ , abstract = {Quasi-solid-state batteries (QSSBs) are attracting considerable interest as a promising approach to enhance battery safety and electrochemical performance. However, QSSBs utilizing high-capacity active materials with substantial volume fluctuations, such as Si microparticle (SiMP) anodes and Ni-rich cathodes (NCM811), suffer from unstable interfaces due to contact loss during cycling. Herein, an in situ interlocking electrode–electrolyte (IEE) system is introduced, leveraging covalent crosslinking between acrylate-functionalized interlocking binders on active materials and crosslinkers within the quasi-solid-state electrolyte (QSSE) to establish a robust, interconnected network that maintains stable electrode–electrolyte contact. This IEE system addresses the limitations of liquid electrolyte and QSSE configurations, evidenced by low voltage hysteresis in (de)lithiation peaks over 200 cycles, stable interfacial resistance throughout cycling, and the absence of void formation. A pressure-detecting cell kit further confirms that the IEE system exhibits lower pressure changes during cycling without any voltage fluctuations from contact loss. Moreover, the SiMP||NCM811 full cell with the IEE system demonstrates superior electrochemical performance, and a bi-layer pouch cell configuration achieves an impressive energy density of 403.7 Wh kg −1 /1300 Wh L −1 , withstanding mechanical abuse tests such as folding and cutting, providing new insights into high-energy-density QSSBs.}, archive = {J_ADVS}, author = {Dong-Yeob Han and Im Kyung Han and Jin Yong Kwon and Seoha Nam and Saehyun Kim and Youngjin Song and Yeongseok Kim and Youn Soo Kim and Soojin Park and Jaegeon Ryu}, doi = {10.1002/advs.202417143}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417143}, shortjournal = {Adv. Sci.}, title = {Covalently interlocked Electrode–Electrolyte interface for high-energy-density quasi-solid-state lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). A live cell imaging-compatible bioreactor for the interrogation of cellular responses to modulated flow conditions. ADVS, 12(22), 2417141. (www)

  @article{ , abstract = {Although being invaluable tools in biomedical research, traditional 2D cell culture models often fail in recapitulating complex environments, limiting their predictive power. To address this limitation, it have developed an open-source, low-cost system that combines long-term 3D cell culture under controlled perfusion conditions with live-cell imaging. By integrating bioprinted extracellular matrix-based scaffolds, this study mimics mechanical and biochemical cues experienced by cells within complex tissue contexts. Here, this system is used to generate a model of the cerebrospinal fluid-filled subarachnoid space to study responses of resident cell types such as meningothelial cells to altered fluid flow conditions. Using fluorescent biosensors, it demonstrates that meningothelial cells respond to modulated fluid flow by differentially activating focal adhesion kinase, a key mechanosensor. The model thus not only provides a powerful platform for investigating the impact of mechanical and other cues on cellular responses, but also bears great potential for the generation of impactful cell biological and pathophysiological models.}, archive = {J_ADVS}, author = {Subashree Srinivasan and Valerie H. Huhle and Claudia C. Bippes and Nina Tanner and Stephan Frank and Hanspeter E. Killer and Corina Kohler and Albert Neutzner}, doi = {10.1002/advs.202417141}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417141}, shortjournal = {Adv. Sci.}, title = {A live cell imaging-compatible bioreactor for the interrogation of cellular responses to modulated flow conditions}, volume = {12}, year = {2025}, }
• (2025). Zinc-doping-induced electronic states modulation of molybdenum carbide: Expediting rate-determining steps of sulfur conversion in lithium-sulfur batteries. ADVS, 12(22), 2417126. (www)

  @article{ , abstract = {Enhancing Li 2 S deposition and oxidation kinetics in lithium-sulfur batteries, especially the potential-limiting step under lean electrolyte, can be effectively achieved by developing conductive catalysts. In this study, by using ZnMoO 4 as precursors, Zn-doped molybdenum carbide microflowers (Zn-Mo 2 C) composed of speared porous sheets are fabricated with a hierarchically ordered structure. Density functional theory calculations indicate that Zn doping shifts the d-band center on Mo atoms in Mo 2 C upward, promotes the elevation of certain antibonding orbitals in Mo─S bonds above the Fermi level, enhances d-p interaction between lithium polysulfides (LiPSs) and catalysts, weakens both S─S and Li─S bonds of LiPSs. Incorporating Zn significantly reduces the Gibbs free energy barrier for the rate-limiting step of the Li 2 S 2 → Li 2 S conversion, from 0.52 eV for Mo 2 C to just 0.05 eV for Zn-doped Mo 2 C. Thus, the synthesized Zn-Mo 2 C demonstrates impressive bifunctional electrocatalytic performance, significantly advancing sulfur reduction and Li 2 S decomposition. Moreover, this modification enhances charge transfer within the Zn-Mo 2 C/LiPSs system, synergistically accelerating the kinetics of Li 2 S 4 to Li 2 S reduction and Li 2 S oxidation. The Zn-Mo 2 C/S cathode demonstrates impressive electrochemical performance, achieves remarkable cycling stability with a minimal capacity decay of 0.021% per cycle over 1000 cycles at 5 C, underscoring its potential for high-energy applications.}, archive = {J_ADVS}, author = {Bin Qin and Yanmei Li and Qun Wang and Si Zhang and Jinglin Zhang and Bin Wang and Peijia Wang and Yuhan Chen and Weiqi Yao and Fang Wang}, doi = {10.1002/advs.202417126}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417126}, shortjournal = {Adv. Sci.}, title = {Zinc-doping-induced electronic states modulation of molybdenum carbide: Expediting rate-determining steps of sulfur conversion in lithium-sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). Favorable desolvation and uniform zn deposition of silica modified zn anode for high performance aqueous zn-ion batteries. ADVS, 12(22), 2417121. (www)

  @article{ , abstract = {The instability of Zn anode resulting from corrosion and dendritic growth remain impeding the development of aqueous zinc-ion batteries (AZIBs). In addition, the desolvation on the Zn surface is sluggish, which hinders the reaction kinetics and fast charge/discharge behavior of AZIBs. Herein, the uniform Zn deposition and fast desolvation are realized by using a hydrophilic fumed nano-silica coating with zinc alginate (Alg) as a functional binder (Alg/SiO 2 @Zn). Combined theoretical calculation and experimental investigations show the interaction between the H 2 O in the solvation structure and -OH functional group of SiO 2 facilitates the desolvation process. In addition to the Zn 2+ guiding effect of Alg, the fast Zn 2+ diffusion along SiO 2 endows the homogeneous Zn deposition. Consequently, Alg/SiO 2 @Zn symmetric cell demonstrates exceptional plating/stripping reversibility and excellent long-term cycle life at both 1 and 10 mAh cm −2 . A full cell assembled with Alg/SiO 2 @Zn and NaV 3 O 8 · x H 2 O cathode achieves a high capacity of 129 mAh g −1 at 4 A g −1 over 2650 cycles. Even under −20 °C, the battery maintains a high capacity of 136.5 mAh g −1 at 1 A g −1 after 1000 stable cycles. This study provides a facile strategy to achieve a highly stable Zn anode and gains deep insight into desolvation modulation via surface modification.}, archive = {J_ADVS}, author = {Wangsheng Yuan and Kai Jin and Shanbao Zou and Yishan Jin and Yishuang He and Xinhai Yuan and Peng Han and Lijun Fu and Yuping Wu}, doi = {10.1002/advs.202417121}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417121}, shortjournal = {Adv. Sci.}, title = {Favorable desolvation and uniform zn deposition of silica modified zn anode for high performance aqueous zn-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Reversible high-affinity binding of coagulation factor xa to zeolites induces accelerated blood coagulation. ADVS, 12(22), 2417099. (www)

  @article{ , abstract = {Zeolite is recognized as an essential hemostatic material for controlling massive bleeding. Elucidating the procoagulant mechanism of zeolite is critically important, as it will facilitate the rational design of more effective zeolite-based hemostatic materials. In this study, it is discovered an extremely strong, calcium-dependent interaction between coagulation factor Xa (FXa) and zeolite—termed target-specific biorecognition—that mimics the FXa/factor Va (FXa/FVa) interface formed during the natural coagulation cascade. This interaction alters the prothrombin activation pathway to a more efficient mechanism, significantly amplifying FXa activity. Notably, the complex structure and FXa activity can be reversibly modulated through Na + /Ca 2+ ion exchange of zeolites, offering a novel strategy for dynamically tuning enzymatic activity. Furthermore, this protein-zeolite based biorecognition system, mediated by reversible interactions, represents a promising biomimetic platform for regulating protein bioactivity in cell-free applications, extending its utility beyond hemostatic material development.}, archive = {J_ADVS}, author = {Chaojie Shi and Meijuan He and Hao Chen and Xuefei Wei and Liping Xiao and Xiaoqiang Shang and Yifeng Shi and Qi Wang and Lisha Yu and Jie Fan}, doi = {10.1002/advs.202417099}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417099}, shortjournal = {Adv. Sci.}, title = {Reversible high-affinity binding of coagulation factor xa to zeolites induces accelerated blood coagulation}, volume = {12}, year = {2025}, }
• (2025). Autonomous self-evolving research on biomedical data: The DREAM paradigm. ADVS, 12(22), 2417066. (www)

  @article{ , abstract = {In contemporary biomedical research, the efficiency of data-driven methodologies is constrained by large data volumes, the complexity of tool selection, and limited human resources. To address these challenges, a Data-dRiven self-Evolving Autonomous systeM (DREAM) is developed as the first fully autonomous biomedical research system capable of independently conducting scientific investigations without human intervention. DREAM autonomously formulates and evolves scientific questions, configures computational environments, and performs result evaluation and validation. Unlike existing semi-autonomous systems, DREAM operates without manual intervention and is validated in real-world biomedical scenarios. It exceeds the average performance of top scientists in question generation, achieves a higher success rate in environment configuration than experienced human researchers, and uncovers novel scientific findings. In the context of the Framingham Heart Study, it demonstrated an efficiency that is over 10 000 times greater than that of average scientists. As a fully autonomous, self-evolving system, DREAM offers a robust and efficient solution for accelerating biomedical discovery and advancing other data-driven scientific disciplines.}, archive = {J_ADVS}, author = {Luojia Deng and Yijie Wu and Yongyong Ren and Hui Lu}, doi = {10.1002/advs.202417066}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417066}, shortjournal = {Adv. Sci.}, title = {Autonomous self-evolving research on biomedical data: The DREAM paradigm}, volume = {12}, year = {2025}, }
• (2025). Longitudinal, multimodal tracking reveals lasting neurovascular impact of individual microinfarcts. ADVS, 12(22), 2417003. (www)

  @article{ , abstract = {Microinfarcts, the “invisible lesions”, are prevalent in aged and injured brains and associated with cognitive impairments, yet their neurophysiological impact remains largely unknown. Using a multimodal chronic neural platform that combines functional microvasculature imaging with spatially resolved neural recording, the neurovascular effect of a single microinfarct is investigated. Unlike larger strokes, microinfarcts induced only temporary suppression of neural activity with minimal cell death, with recovery paralleling vasculature remodeling at the infarct core. Neural activity is more severely suppressed at the shallower cortical layer despite milder vascular damage compared to deeper layers, and the excitability of fast-spiking interneurons attenuation is accompanied by heightened bursting of regular spiking neurons. Spike phase locking at the low-gamma band is disrupted, indicating a lasting impairment of long-range assembly communication. These results highlight the subtle yet significant neurovascular disruptions of a single microinfarct.}, archive = {J_ADVS}, author = {Yifu Jin and Fei He and Haad Rathore and Yingchu Sun and Jia-ao Zhang and Xinyu Li and Rongkang Yin and Hanlin Zhu and Chong Xie and Lan Luan}, doi = {10.1002/advs.202417003}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2417003}, shortjournal = {Adv. Sci.}, title = {Longitudinal, multimodal tracking reveals lasting neurovascular impact of individual microinfarcts}, volume = {12}, year = {2025}, }
• (2025). Ruthenium single-atom nanozyme driven sonosensitizer with oxygen vacancies enhances Electron–Hole separation efficacy and remodels tumor microenvironment for sonodynamic-amplified ferroptosis. ADVS, 12(22), 2416997. (www)

  @article{ , abstract = {Sonodynamic therapy (SDT) has emerged as a promising noninvasive approach for tumor therapy. However, the effectiveness of traditional inorganic semiconductor sonosensitizers is hindered by rapid electron (e − ) and hole (h + ) recombination under ultrasonic (US) stimulation, as well as the hypoxic and reductive conditions of tumor microenvironment (TME), which limit the generation of reactive oxygen species (ROS). Herein, a ruthenium (Ru) single-atom nanozyme-driven superimposition-enhanced titanium dioxide-based sonosensitizer (Ru/TiO 2-x SAE) is presented that features sufficient oxygen vacancies and high e − /h + separation efficiency. Through synchrotron radiation-based X-ray absorption spectroscopy and extended X-ray absorption fine structure analysis it is confirmed that oxygen vacancies in TiO 2-x nanoparticles promote the immobilization of single-atomic Ru, forming Ru-O₄ active sites. Density functional theory calculations demonstrate that oxygen vacancies alter the electronic structure of nanosensitizer, enhanced e − /h + separation, increasing oxygen adsorption, and accelerating reaction kinetics under US stimulation, ultimately improving ROS production. Moreover, Ru/TiO 2-x SAE boosts sonodynamic efficacy by mitigating the hypoxic and reductive TME. This is attributed to its catalase- and glutathione peroxidase 4-like activities, which facilitate the generation of ROS and trigger lipid peroxidation-mediated ferroptosis. These findings highlight the innovative role of single-atom Ru in optimizing sonosensitizers for SDT-induced ferroptosis, demonstrating its potential for advancing cancer therapy.}, archive = {J_ADVS}, author = {Yang Zhu and Dengliang Wang and Chengzhong Du and Tiantian Wu and Penghui Wei and Hongjia Zheng and Guanting Li and ShunZhe Zheng and Lichao Su and Lingjun Yan and Yongrui Hu and Huimin Wang and Lisen Lin and Chenyu Ding and Xiaoyuan Chen}, doi = {10.1002/advs.202416997}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416997}, shortjournal = {Adv. Sci.}, title = {Ruthenium single-atom nanozyme driven sonosensitizer with oxygen vacancies enhances Electron–Hole separation efficacy and remodels tumor microenvironment for sonodynamic-amplified ferroptosis}, volume = {12}, year = {2025}, }
• (2025). Upcycling waste low-density polyethylene into highly crystalline graphite. ADVS, 12(22), 2416978. (www)

  @article{ , abstract = {Only a small fraction of the global plastic waste is recycled, and the recycled materials are often of lower quality. For example, only 14% of the world's total plastic is recycled, with low-density polyethylene (LDPE) accounting for only 4% of it. This study presents a novel approach to transforming waste LDPE into electrically conductive artificial graphite with high crystallinity using stabilization and graphitization processes. This method achieves a carbon yield of 89.4%, surpassing yields from conventional polymer precursors, such as polyacrylonitrile and polyamide. The resulting LDPE-derived graphite (LGP) exhibits a high crystallinity and electrical conductivity, twice those of natural graphite and comparable to those of artificial graphite, which typically requires extensive heat treatment to prepare. LGP can be used in pastes and inks for advanced applications, such as 3D printing, flexible electrodes, heaters, and photothermal devices. Additionally, the high crystallinity of LGP enables the formation of larger graphene oxide (GO) with an average size of 4.1 ± 2.4 µm, because the larger crystalline domains in LGP facilitate the exfoliation process. The approach developed in this study contributes significantly to LDPE waste management and provides a pathway for the fabrication of valuable carbon materials for broad industrial applications.}, archive = {J_ADVS}, author = {Woojae Jeong and Haneul Nam and Hwansoo Shin and Sooin Hwang and Junho Lee and Dongho Lee and Hyeong Jun Kim and Jingi Ahn and Tae Hee Han}, doi = {10.1002/advs.202416978}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416978}, shortjournal = {Adv. Sci.}, title = {Upcycling waste low-density polyethylene into highly crystalline graphite}, volume = {12}, year = {2025}, }
• (2025). Single-cell sequencing-guided annotation of rare tumor cells for deep learning-based cytopathologic diagnosis of early lung cancer. ADVS, 12(22), 2416921. (www)

  @article{ , abstract = {Deep learning (DL) models for medical image analysis are majorly bottlenecked by the lack of well-annotated datasets. Bronchoalveolar lavage (BAL) is a minimally invasive procedure to diagnose lung cancer, but BAL cytology suffers from low sensitivity. The success of DL in BAL cytology is rare due to the rarity of exfoliated tumor cells (ETCs) and their subtle morphological differences from normal cells. Single-cell DNA sequencing (scDNA-Seq) is utilized as an objective ground truth of ETC annotation for generating an unbiased, accurately annotated dataset comprising 580 ETCs and 1106 benign cells from BAL cytology slides. A DL model is developed, to distinguish ETC from benign cells in BAL fluid, achieving an Area Under the Curve of 0.997 and 0.956 for detecting large- and small-sized ETCs, respectively. The model is applied in a discovery cohort (n = 156) to establish BAL-based cytopathologic diagnostic model for lung cancer. The model is evaluated in a validation cohort (n = 158), and yielded 47.6% sensitivity and 97.7% specificity in lung cancer diagnosis, outperforming cytology with improved sensitivity (47.6% vs 19.0%). In an external validation cohort (n = 141), the model achieved 60.0% sensitivity and 92.5% specificity in lung cancer diagnosis.}, archive = {J_ADVS}, author = {Yichun Zhao and Ruoran Qiu and Zhuo Wang and Yunyun Li and Xu Yang and Yanlin Li and Xiaohan Shen and Yun Liu and Ziqiang Chen and Qihan You and Qihui Shi}, doi = {10.1002/advs.202416921}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416921}, shortjournal = {Adv. Sci.}, title = {Single-cell sequencing-guided annotation of rare tumor cells for deep learning-based cytopathologic diagnosis of early lung cancer}, volume = {12}, year = {2025}, }
• (2025). Annexin a3 represses endothelial permeability and inflammation during sepsis via actin cytoskeleton modulation. ADVS, 12(22), 2416904. (www)

  @article{ , abstract = {Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis. The role of annexin A3 (ANXA3) in regulating endothelial permeability and inflammation during sepsis is explored using ANXA3 knockout mice and primary human umbilical vein endothelial cells (HUVECs). The absence of ANXA3 exacerbated sepsis outcomes, including increased mortality, lung injury, leukocyte infiltration, and vascular permeability. ANXA3 is highly expressed in endothelial cells and its loss results in the formation of cytoskeletal stress fibers and a decrease in the expression of the junction proteins zonula occludens (Zo)-1, vascular endothelial (VE)-cadherin, and claudin 5, leading to increase permeability. ANXA3 knockdown also upregulates E-selectin (CD62E) expression through the phosphorylation of activating transcription factor 2 (ATF2), which increases monocyte adhesion in HUVECs after LPS stimulation. Inhibiting actin polymerization reverse these effects. Thus, ANXA3 stabilizes the actin cytoskeleton, playing a protective role in endothelial dysfunction during sepsis.}, archive = {J_ADVS}, author = {Manyu Xing and Shuang Liang and Wei Cao and Qulian Guo and Wangyuan Zou}, doi = {10.1002/advs.202416904}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416904}, shortjournal = {Adv. Sci.}, title = {Annexin a3 represses endothelial permeability and inflammation during sepsis via actin cytoskeleton modulation}, volume = {12}, year = {2025}, }
• (2025). Neophytadiene, a plant specialized metabolite, mediates the virus-vector-plant tripartite interactions. ADVS, 12(22), 2416891. (www)

  @article{ , abstract = {While interactions between viruses and their vectors, as well as between viruses and host plants, have been extensively studied, the genetic mechanisms underlying tripartite interactions remain largely unknown. In this study, phenotypic assays are integrated with molecular biology and functional genomic approaches to elucidate the tripartite interactions involving tomato chlorosis virus (ToCV), a major threat to tomato production worldwide, the whitefly, Bemisia tabaci , an insect vector, and host plants. ToCV infection induces the production of a chlorophyll degradation product that acts as a volatile attractant for whiteflies. Furthermore, the suppression of Lhca4 , a gene encoding subunit of light-harvesting complex I in host plants, by the P9 protein of ToCV leads to chlorophyll degradation and neophytadiene biosynthesis. Overexpression of Lhca4 reduced chlorophyll production and ToCV infection. Furthermore, OBP2, an odorant-binding protein from B. tabaci , capable of binding to neophytadiene is identified. Suppression of BtOBP2 impaired vector's subsequent preference for ToCV-infected plants. The results not only reveal the genetic underpinnings, including ToCV P9, host plant Lhca4, and whitefly BtOBP2, governing the virus-vector-plant interactions, but also highlight neophytadiene, a specialized metabolite in host plants, as a mediator of intricate multitrophic interactions, suggesting new avenues for managing plant virus vectored by insects.}, archive = {J_ADVS}, author = {Xiao-bin Shi and Hao Yue and Yan Wei and Evan L. Preisser and Pei Wang and Jiao Du and Ji-xing Xia and Kai-long Li and Xin Yang and Jian-bin Chen and Song-bai Zhang and Zhan-hong Zhang and Xu-guo Zhou and De-yong Zhang and Yong Liu}, doi = {10.1002/advs.202416891}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416891}, shortjournal = {Adv. Sci.}, title = {Neophytadiene, a plant specialized metabolite, mediates the virus-vector-plant tripartite interactions}, volume = {12}, year = {2025}, }
• (2025). The bioengineering of microspheric skin organoids and their application in drug screening. ADVS, 12(22), 2416863. (www)

  @article{ , abstract = {It has been a challenge to develop skin models which exhibit the key characteristics of the human skin and facilitate high-throughput drug screening. In this study, a method is developed to construct microspheric skin organoids based on spinning bioreactors. The organoid consists of a core-shell structure to mimic the bilayered skin structure, where the shell is composed of cultured human keratinocytes, resembling the epidermis, and the core, which mimics the dermis, comprises human dermal fibroblasts and collagen. In fabrication of the organoid, the cores are cultured with keratinocytes in spinner flasks under defined conditions to facilitate epidermal growth and differentiation to form mature barrier. To enable efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt activation, and Minoxidil is identified to induce epidermal Wnt/beta-catenin pathway signaling. Thus, the study has developed a novel method for efficient preparation of uniform microspheric skin organoids with potential applications for high-throughput drug testing and screening.}, archive = {J_ADVS}, author = {Jundong Xie and Qingyang Yang and Yanan Zhang and Ke Zheng and Hongya Geng and Yaojiong Wu}, doi = {10.1002/advs.202416863}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416863}, shortjournal = {Adv. Sci.}, title = {The bioengineering of microspheric skin organoids and their application in drug screening}, volume = {12}, year = {2025}, }
• (2025). Ultrasound cavitation enables rapid, initiator-free fabrication of tough anti-freezing hydrogels. ADVS, 12(22), 2416844. (www)

  @article{ , abstract = {Hydrogels are often synthesized with thermal or photo-initiated gelation, leaving alternative energy sources less explored. While ultrasound has been used for polymer synthesis and mechanochemistry, its application through cavitation for hydrogel synthesis as a constructive force is rare, and the underlying sonochemical mechanisms are poorly understood. Here, the application and mechanism of ultrasound cavitation for rapid, initiator-free, and oxygen-tolerant fabrication of tough anti-freezing hydrogels is reported. By incorporating polyol solvents and interpenetrating polymers into the gelling solution, radical generation is amplified and network formation is enhanced. Using tough polyacrylamide-alginate hydrogels as a model system, rapid gelation (as fast as 2 minutes) and high fracture toughness (up to 600 J m − 2 ) is demonstrated. By varying ultrasound intensity, crosslinker-to-monomer ratio, and glycerol concentration, the synthesis-structure-property relation is established for the resulting sonogels and the underlying mechanism is uncovered using combined molecular, optical, and mechanical testing techniques. The coupling of gelation and convection under ultrasound results in sonogels with unique structural and mechanical properties. Additionally, the fabrication of hydrogel constructs is demonstrated using both non-focused and high-intensity focused ultrasound. This work establishes a foundation for ultrasound-driven sono-fabrication and highlights new avenues in soft materials, advanced manufacturing, bioadhesives, and tissue engineering.}, archive = {J_ADVS}, author = {Yixun Cheng and Stephen Lee and Yihang Xiao and Shou Ohmura and Louis-Jacques Bourdages and Justin Puma and Zixin He and Zhen Yang and Jeremy Brown and Jean Provost and Jianyu Li}, doi = {10.1002/advs.202416844}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416844}, shortjournal = {Adv. Sci.}, title = {Ultrasound cavitation enables rapid, initiator-free fabrication of tough anti-freezing hydrogels}, volume = {12}, year = {2025}, }
• (2025). A general strategy for C(sp3)─H bond etherification via quinoline derivative-mediated electrolysis. ADVS, 12(22), 2416803. (www)

  @article{ , abstract = {Electrooxidative coupling of C(sp 3 )─H bonds with nucleophiles offers an attractive method for constructing C─C and C─X bonds without sacrificial oxidants. However, the direct electrochemical approach requires the nucleophilic reagent to have a higher potential than the C(sp 3 )─H coupling partners, which restricts the substrate scope. In this study, a quinoline derivative is introduced as an electrochemical mediator, enabling efficient C─H bond etherification with reduced reliance on the electronic properties of substrates. The catalytic system demonstrates broad substrate compatibility, extending to C(sp 3 )─H coupling partners featuring a diverse range of C─H bonds, including tertiary benzylic C─H bonds and unactivated C(sp 3 )─H bonds. Mechanistic investigations confirm the role of the electrocatalyst in the hydrogen atom transfer (HAT) process. This method provides a versatile and efficient strategy for the late-stage functionalization of bioactive molecules.}, archive = {J_ADVS}, author = {Yousen Xu and Hao Wu and ChenXi Zhu and Minjun Tu and Lei Zhang}, doi = {10.1002/advs.202416803}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416803}, shortjournal = {Adv. Sci.}, title = {A general strategy for C(sp3)─H bond etherification via quinoline derivative-mediated electrolysis}, volume = {12}, year = {2025}, }
• (2025). Micro-coil neuromodulation at single-cell and circuit levels for inhibiting natural neuroactivity, neutralizing electric neural excitation, and suppressing seizures. ADVS, 12(22), 2416771. (www)

  @article{ , abstract = {Micromagnetic stimulation (µMS) emerges as a complementary method for neuromodulation. Despite major advances in neural interface technology, there are limited options for neural inhibition. Here, a microchip-based implantable micro-coil device is presented to achieve high spatial precision for cortical inhibition. Cortical in vivo two-photon imaging of spontaneous neural activity showed µMS reversibly suppressed single cells, and as µMS magnitude is increased, the suppressed cell population increased from 14% to 41%. At the circuit level, the average suppressed area is 0.05 mm 2 , seven times smaller than the activated area induced by micro-electrode stimulation (µES). It is discovered that neurons responded more strongly to µMS than to µES, which is exploited to effectively neutralize the neural excitation induced by concurrently delivered strong µES (80 µA). Moreover, µMS mitigates hyperactive neural firing caused by pharmacologically induced seizures, reducing seizure amplitude by 54%. These findings underscore the potential of µMS as a precise, effective, and versatile tool for localized neuromodulation with an effect of opposite polarity from µES. Complementing optogenetic and electrical stimulation for multi-functional neural interfaces, µMS holds promise as a unique neuroscience research tool and as a potential therapeutic intervention method for precisely suppressing hyperactive brain circuits.}, archive = {J_ADVS}, author = {Kayeon Kim and Xiyuan Liu and Bingdong Chang and Guanghui Li and Gwendoline A. E. Anand and Su Genelioglu and Alexandra Katherine Isis Yonza and Andrew J Whalen and Rune W Berg and Shelley I Fried and Anpan Han and Changsi Cai}, doi = {10.1002/advs.202416771}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416771}, shortjournal = {Adv. Sci.}, title = {Micro-coil neuromodulation at single-cell and circuit levels for inhibiting natural neuroactivity, neutralizing electric neural excitation, and suppressing seizures}, volume = {12}, year = {2025}, }
• (2025). Nanoparticle delivery of antisense miR162 inhibits invasive habitat adaption of alternanthera philoxeroides. ADVS, 12(22), 2416747. (www)

  @article{ , abstract = {Phenotypic flexibility in adaptive traits is crucial for organisms to thrive in changing environments. Alternanthera philoxeroides , native to South America, has become an invasive weed in Asia. The mechanism by which invasive capacity is achieved remains unknown. Here, it is demonstrated that miR162 plays a crucial role in submergence survival for A. philoxeroides . These results highlight that the level of miR162 significantly increases in stems from 3 to 48 h upon water submergence, and knockdown of miR162 via TRV-based VIGS system significantly disrupts stem elongation upon water submergence, ultimately resulting in a failure of plants protruding from the water surface. Interestingly, miR162 is not up-regulated in the noninvasive congeneric alien species Alternanthera pungens , which is also native to South America but has retained its original habitats in Asia. The presence of anaerobic responsive elements (AREs) in the promoter sequences of MIR162 from A. philoxeroides rather than A. pungens may contribute to its invasion capacity. Importantly, nanoparticle delivery of antisense RNA oligonucleotides of miR162 significantly impairs stem elongation during water submergence. Thus, our findings reveal that the achievement of specific miRNA activity can drive rapid phenotypic variation, and miR162 has the potential as a bio-pesticide for controlling the invasive growth of A. philoxeroides .}, archive = {J_ADVS}, author = {Qianqian Hu and Erfeng Kou and Xiuzhen Liao and Ruiyi Qiu and Qi Tang and Huan Zhang and Yun Zheng and Ji Yang and Binglian Zheng}, doi = {10.1002/advs.202416747}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416747}, shortjournal = {Adv. Sci.}, title = {Nanoparticle delivery of antisense miR162 inhibits invasive habitat adaption of alternanthera philoxeroides}, volume = {12}, year = {2025}, }
• (2025). Bi-induced few-layered graphite frameworks as efficient interfacial transitions toward ultrafast potassium storage. ADVS, 12(22), 2416742. (www)

  @article{ , abstract = {Bismuth is a promising anode material for potassium-ion batteries due to its green, non-toxic and high theoretical capacity (384 mAh g −1 ). However, the sluggish reaction kinetics and excessive volume expansion during cycling limit its practical application. Herein, Bi-induced few-layered graphite frameworks are in situ encapsulated on the surface of Bi nanoparticles, based on the mechanism of graphitization by rearrangement of interstitial carbon atoms during the nucleation process of Bi, while these composite particles are embedded in Bi-doped porous carbon fibers composite. The graphite frameworks can stabilize the structure while serving as an efficient interfacial transfer layer, enabling rapid transport of both potassium ions and electrons. Bi atoms doped into the carbon fiber matrix effectively enhances the potassium ion transport kinetics in amorphous carbon by lowering the migration energy barrier of potassium ions in the carbon layer. The porous structure effectively alleviates the volume expansion of Bi nanoparticles during cycling, which synergistically results in superior high-rate performance and cycling stability. Finally, the capacity can reach 215 mAh g −1 at 10 A g −1 , and a capacity retention rate of 83.8% is achieved after 6000 cycles at 10 A g −1 with an ultra-low decay rate of 0.00278% per cycle.}, archive = {J_ADVS}, author = {Bozhi Yang and Xin Min and Xinyu Zhu and Shaorou Ke and Shujie Yang and Ya Chen and Wei Wang and Ruiyu Mi and Yangai Liu and Zhaohui Huang and Xi Kai and Minghao Fang and R. Vasant Kumar}, doi = {10.1002/advs.202416742}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416742}, shortjournal = {Adv. Sci.}, title = {Bi-induced few-layered graphite frameworks as efficient interfacial transitions toward ultrafast potassium storage}, volume = {12}, year = {2025}, }
• (2025). Rapid and noninvasive early detection of lung cancer by integration of machine learning and salivary metabolic fingerprints using MS LOC platform: A large-scale multicenter study. ADVS, 12(22), 2416719. (www)

  @article{ , abstract = {Most lung cancer (LC) patients are diagnosed at advanced stages due to the lack of effective screening tools. This multicenter study analyzes 1043 saliva samples (334 LC cases and 709 non-LC cases) using a novel high-throughput platform for metabolic fingerprint acquisition. Machine learning identifies 35 metabolic features distinguishing LC from non-LC subjects, enabling the development of a classification model named SalivaMLD. In the validation set and test set, SalivaMLD demonstrates strong diagnostic performance, achieving an area under the curve of 0.849-0.850, a sensitivity of 81.69–83.33%, and a specificity of 74.23–74.39%, outperforming conventional tumor biomarkers. Notably, SalivaMLD exhibits superior accuracy in distinguishing early stage LC patients. Hence, this rapid and noninvasive screening method may be widely applied in clinical practice for LC detection.}, archive = {J_ADVS}, author = {Shuang Lin and Runlan Yan and Junqi Zhu and Bei Li and Yinyan Zhong and Shuang Han and Huiting Wang and Jianmin Wu and Zhao Chen and Yuyue Jiang and Aiwu Pan and Xuqing Huang and Xiaoming Chen and Pingya Zhu and Sheng Cao and Wenhua Liang and Peng Ye and Yue Gao}, doi = {10.1002/advs.202416719}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416719}, shortjournal = {Adv. Sci.}, title = {Rapid and noninvasive early detection of lung cancer by integration of machine learning and salivary metabolic fingerprints using MS LOC platform: A large-scale multicenter study}, volume = {12}, year = {2025}, }
• (2025). Defect engineering in wüstite: Unlocking control over iron morphologies in gas-solid reduction. ADVS, 12(22), 2416713. (www)

  @article{ , abstract = {Hydrogen-based direct reduction (HyDR) technology has emerged as a promising pathway for sustainable steelmaking. However, the efficiency and stability of HyDR are critically influenced by the microstructure evolution of iron during gas-solid reduction reactions. Despite significant research on the reduction mechanisms of hydrogen (H 2 ) and carbon monoxide (CO) with iron oxides, key aspects of the interplay between internal defects, pore dynamics, and reduction chemistry remain unresolved. In this study, the morphological evolution of iron during reduction with H 2 and CO across a full concentration range at 900 °C is explored, establishing a direct link between lattice distortions in wüstite (Fe x O) and the resultant iron microstructure. Complementary analyses reveal that the concentration of defects in Fe x O governs these distortions. Specifically, low CO concentrations (< 80%) induce limited large-scale defects, leading to single-point nucleation and the growth of filament-shaped iron whiskers. Conversely, H₂ and high CO concentrations (> 80%) create a high density of large-scale defects, promoting multi-point nucleation and the aggregation of tumor-shaped iron structures. This work provides a multiscale perspective on how defect engineering in Fe x O modulates the morphologies of iron during reduction, offering valuable insights into optimizing reaction pathways to enhance efficiency and sustainability in materials processing.}, archive = {J_ADVS}, author = {Qinghui Wu and Shuai Wang and Han Zhang and Fuchuan Zhang and Kaihui Ma and Jian Xu}, doi = {10.1002/advs.202416713}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416713}, shortjournal = {Adv. Sci.}, title = {Defect engineering in wüstite: Unlocking control over iron morphologies in gas-solid reduction}, volume = {12}, year = {2025}, }
• (2025). Extracellular vesicular delta-like ligand 3 and subtype transcription factors for small cell lung cancer diagnosis. ADVS, 12(22), 2416711. (www)

  @article{ , abstract = {Small cell lung cancer (SCLC) is associated with high mortality and limited therapeutic options. There is increasing recognition that SCLC harbors molecular heterogeneity. Using a new liquid biopsy assay, it is demonstrated that SCLC subtypes, as determined by patient tumor tissue staining and cell lines, can be accurately identified by measuring the mRNA expression of subtype transcription factors (ASCL1, POU2F3, and NEUROD1) in circulating exosome-rich extracellular vesicles (Exo). Additionally, upregulation of Delta-like ligand 3 (DLL3) mRNA in Exo and its membrane protein (mProtein) in extracellular vesicles associated with tumor (tEV) may distinguish both limited- and extensive-stage SCLC patients from high-risk smokers, with AUC/ROC values of 0.836 and 0.839, respectively. By incorporating Exo-ASCL1 and Exo-POU2F3 mRNA expression with DLL3 Exo-mRNA/tEV-mProtein expression, the classifier enhances the AUC/ROC to 0.912 and 0.963 for limited- and extensive-stage SCLC patients, respectively.}, archive = {J_ADVS}, author = {Hong Li and Chi-Ling Chiang and Kwang Joo Kwak and Hsin-Lun Lee and Xinyu Wang and Giulia Romano and Michela Saviana and Robin Toft and Tai-Shan Cheng and Yuehshih Chang and Bi-Da Hsiang and Guan-Wan Liu and Xiaokui Mo and Yifan Ma and Junjie Pan and Xilal Y. Rima and Truc Nguyen Kim and Eduardo Reategui and Chia-Ning Shen and Yeh-Shiu Chu and Carlo Croce and Peter Mu-Hsin Chang and Yi-Chen Yeh and David P. Carbone and Chi-Ying F. Huang and Chi-Lu Chiang and Patrick Nana-Sinkam and L. James Lee}, doi = {10.1002/advs.202416711}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416711}, shortjournal = {Adv. Sci.}, title = {Extracellular vesicular delta-like ligand 3 and subtype transcription factors for small cell lung cancer diagnosis}, volume = {12}, year = {2025}, }
• (2025). Anion exchange membrane seawater electrolysis at 1.0 a cm−2 with an anode catalyst stable for 9000 h. ADVS, 12(22), 2416661. (www)

  @article{ , abstract = {Hydrogen production through seawater electrolysis is promising but challenging due to severe anode corrosion by chlorine (Cl − ) ions. Herein, a corrosion-resistant NiFe layered double hydroxide electrode (CAPist-S1) is reported as a high-performance electrocatalyst for seawater oxidation, achieving an industrial-level current density of 1.0 A cm −2 at overpotentials of 200 and 220 mV in alkaline simulated (1 M KOH + 0.5 M NaCl) and natural (1 M KOH + seawater) seawater, respectively, along with extraordinary long-term stability over 9000 h under 1.0 A cm −2 in alkaline natural seawater. A dense NiFe LDH interlayer generated between the NiFe LDH nanosheets and metal substrate is found to efficiently retard the penetration of Cl − ions to the substrate surface, improving the resistance to Cl − ions corrosion. Furthermore, this dense interlayer is an essential prerequisite for establishing a dynamic equilibrium between Fe leaching and redeposition over the in situ formed FeOOH, and this dynamic equilibrium can in turn stabilize the dense interlayer, maintaining the activity of CAPist-S1 during prolonged electrolysis. Using CAPist-S1 in an anion exchange membrane (AEM) seawater electrolyzer, the obtained electrolyzer stably functions over 700 h at 1.0 A cm −2 under room temperature, indicating promising prospects for industrial seawater electrolysis application.}, archive = {J_ADVS}, author = {Jian Du and Zhiheng Li and Linqin Wang and Yunxuan Ding and Wentao Ye and Wenxing Yang and Licheng Sun}, doi = {10.1002/advs.202416661}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416661}, shortjournal = {Adv. Sci.}, title = {Anion exchange membrane seawater electrolysis at 1.0 a cm−2 with an anode catalyst stable for 9000 h}, volume = {12}, year = {2025}, }
• (2025). A reversible and dynamic surface functionalization for fluidity controlled multivalent recognition of lectins and bacteria. ADVS, 12(22), 2416658. (www)

  @article{ , abstract = {The paper reports the design of multivalent bacterial receptors based on reversible self-assembled monolayers (rSAMs) on gold and glass substrates, mimicking the ligand display on host cells and extracellular matrices. The layers consist of α-(4-amidinophenoxy)alkanes decorated at the ω-position with β-galactose (Gal) or sialic acid (SA). The former acts as a mobile ligand binding to the complementary adhesin, LecA, a key virulence factor of the multi-drug-resistant bacterium Pseudomonas aeruginosa (PA). Binary amphiphile mixtures containing either of these ligands, spontaneously self-assemble on carboxylic acid terminated SAMs on gold or glass surfaces to form rSAMs that are easily tunable with respect to the ligand ratio. It is shown that this results in the ability to construct multi-reusable surfaces featuring strong affinity for the bacterial adhesin and recognitive surfaces for bacteria, the latter demonstrated by incubating a culture of PA or the oral commensal species Streptococcus gordonii (SG) on either Gal or SA functionalized rSAMs. In contrast to the mobile ligand display, surfaces featuring covalently attached “static” ligands exhibited low LecA affinity. This approach to wet chemical surface functionalization is unique in imparting both rapid restorability and adaptability, the latter compatible with heteromultivalent receptor designs for boosting lectin and bacteria affinity and specificity.}, archive = {J_ADVS}, author = {Thomas Hix-Janssens and Adam Tillo and Hanna Isaieva and Zita Lopes da Silva and Zahra Fatahi and Michele Larocca and Gustav Sedelius and Sara Björk Sigurdardóttir and Yulia Sergeeva and Tiba Al-Dujaili and Julia R. Davies and Kushagr Punyani and Börje Sellergren}, doi = {10.1002/advs.202416658}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416658}, shortjournal = {Adv. Sci.}, title = {A reversible and dynamic surface functionalization for fluidity controlled multivalent recognition of lectins and bacteria}, volume = {12}, year = {2025}, }
• (2025). Targeted STING activation using modified ultrasound-responsive microbubbles enhances immune checkpoint blockade against melanoma. ADVS, 12(22), 2416596. (www)

  @article{ , abstract = {Despite the recent successes of immune checkpoint inhibitors (ICIs) in treating advanced melanoma, durable clinical responses still remain limited. To boost immune responses, agents that target immune regulators, such as the Stimulator of Interferon Genes (STING) agonist cyclic GMP-AMP (cGAMP), are being investigated. However, their clinical translation is impeded by poor serum stability, rapid tissue clearance, and T-cell death due to off-target activation. Recently, a novel strategy termed Microbubble-assisted UltraSound-guided Immunotherapy of Cancer (MUSIC) has been reported to selectively deliver cGAMP directly into the cytosol of antigen-presenting cells with spatiotemporal control. The resulting activation of STING and downstream proinflammatory pathways produces antitumor effects in murine models of breast cancer. Herein, this study reports that MUSIC provides curative results in aggressive murine models of melanoma as well. Under ultrasound exposure, MUSIC reduces tumor size, increases overall survival, and synergizes with ICIs to bridge innate and adaptive immunities. The results from this study represent MUSIC's ability to produce potent immune responses in melanoma, thus indicating its potential as an adjuvant for cancers where ICI is the current standard of care.}, archive = {J_ADVS}, author = {Sina Khorsandi and Kristin Huntoon and Yifan Wang and Adam Woodward and Abin Antony and Connor Endsley and Nazia Hafeez and Jared L. Edwards and Nicole McCuen and Prasanna G. Alluri and Betty Y.S. Kim and Wen Jiang and Jacques Lux}, doi = {10.1002/advs.202416596}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416596}, shortjournal = {Adv. Sci.}, title = {Targeted STING activation using modified ultrasound-responsive microbubbles enhances immune checkpoint blockade against melanoma}, volume = {12}, year = {2025}, }
• (2025). Nuclear-localized BCKDK facilitates homologous recombination repair to support breast cancer progression and therapy resistance. ADVS, 12(22), 2416590. (www)

  @article{ , abstract = {Homologous recombination repair (HRR) is crucial for maintaining genomic stability by repairing DNA damage. Despite its importance, HRR's role in cancer progression is not fully elucidated. Here, this work shows that nuclear-localized branched-chain α-ketoacid dehydrogenase kinase (BCKDK) acts as a modulator of HRR, promoting cell resistance against DNA damage-inducing therapy in breast cancer. Mechanistically, this work demonstrates that BCKDK is localized in the nucleus and phosphorylates RNF8 at Ser157, preventing the ubiquitin-mediated degradation of RAD51, thereby facilitating HRR-mediated DNA repair under replication stress. Notably, aberrant expression of the BCKDK/p-RNF8/RAD51 axis correlates with breast cancer progression and poor patient survival. Furthermore, this work identifies a small molecule inhibitor of BCKDK, GSK180736A, that disrupts its HRR function and exhibits strong tumor suppression when combined with DNA damage-inducing drugs. Collectively, this study reveals a new role of BCKDK in regulating HRR, independent of its metabolic function, presenting it as a potential therapeutic target and predictive biomarker in breast cancer.}, archive = {J_ADVS}, author = {Haiying Liu and Jiaqian Feng and Tingting Pan and Pinggen Zhang and Ling Ye and Zetan Jiang and Zilong Zhou and Qiankun Mao and Jian Li and Xinyi Yang and Ping Gao and De Huang and Huafeng Zhang}, doi = {10.1002/advs.202416590}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416590}, shortjournal = {Adv. Sci.}, title = {Nuclear-localized BCKDK facilitates homologous recombination repair to support breast cancer progression and therapy resistance}, volume = {12}, year = {2025}, }
• (2025). Origins, dispersal, and impact: Bidirectional introgression between chinese and european pig populations. ADVS, 12(22), 2416573. (www)

  @article{ , abstract = {Human mediated intra-continental exchange of genetic material among domesticated organisms has never been restricted to a single direction. The introduction of pig breeds between China and Europe aims to enhance economically important traits in local populations. However, the reciprocal introgression pattern, specifically the role of introgressed genes and structural variations (SVs), remains underexplored. A global collection of whole-genome resequencing data is utilized from 418 pigs to generate comprehensive dataset, including single-nucleotide polymorphisms (SNPs) as well as SVs. The analysis reveals incomplete linkage disequilibrium between SVs and adjacent SNPs, highlighting the limitations of conventional SNP-based analyses in capturing the genetic effects of SVs. By examining both population-level SNPs and SVs, bidirectional introgression between Chinese and European pig populations is characterized. It is identified 3558 bidirectional introgressed genomic segments and 30 SVs, with haplotypes at BMP2 , which are associated with improved body size. The origin and allele frequency trajectory of the BMP2 segment are further validated using ancient genomes, suggesting that the body size-enhancing haplotype likely originated from ancient European populations and has since maintained a relatively high allele frequency. Overall, the results highlight the significant role of bidirectional introgression in shaping the genetic composition and phenotypic traits in modern pig breeds.}, archive = {J_ADVS}, author = {Yibin Qiu and Langqing Liu and Min Huang and Donglin Ruan and Rongrong Ding and Zebin Zhang and Enqin Zheng and Shiyuan Wang and Shaoxiong Deng and Xianglun Meng and Xinyan Cheng and Jiaxin Shi and Yingshan Yang and Fuchen Zhou and Sixiu Huang and Huaqiang Yang and Zicong Li and Gengyuan Cai and Zhenfang Wu and Jie Yang}, doi = {10.1002/advs.202416573}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416573}, shortjournal = {Adv. Sci.}, title = {Origins, dispersal, and impact: Bidirectional introgression between chinese and european pig populations}, volume = {12}, year = {2025}, }
• (2025). Inhibition of ferroptosis delays aging and extends healthspan across multiple species. ADVS, 12(22), 2416559. (www)

  @article{ , abstract = {Ferroptosis, a form of iron-dependent cell death, plays a pivotal role in age-related diseases; yet, its impact on cellular senescence and healthspan in mammals remains largely unexplored. This study identifies ferroptosis as a key regulator of cellular senescence, showing that its inhibition can significantly delay aging and extend healthspan across multiple species. During cellular senescence, ferroptosis is progressively exacerbated, marked by increased lipid peroxidation, oxidative stress, and diminished glutathione peroxidase 4 (GPX4) levels. Ferroptosis inducers such as Erastin and RSL3 accelerate senescence; while, inhibitors such as liproxstatin-1 (Lip-1) and ferrostatin-1 (Fer-1) effectively mitigate both chemically and replicatively induced senescence. In vivo, Fer-1 extends lifespan and healthspan in Caenorhabditis elegans , enhances motor function, preserves tissue integrity, and mitigates cognitive decline in both prematurely and naturally aged mice. These effects are attributed to Fer-1's upregulation of GPX4 and inhibition of ferroptosis. Notably, long-term Fer-1 treatment (over 6 months) does not adversely affect body weight or induce aging-related tissue damage but rejuvenates hematological parameters. These findings establish ferroptosis as a critical player in aging dynamics and highlight its inhibition as a promising strategy to extend healthspan and lifespan, providing valuable insights for translational approaches to combat aging and age-related decline.}, archive = {J_ADVS}, author = {Hai-Jun Fu and Xing-Yue Zhou and Da-Lian Qin and Qan Qiao and Qiao-Zhi Wang and Shi-Ying Li and Yun-Fei Zhu and Ya-Ping Li and Jiang-Min Zhou and Hui Cai and Fei-Hong Huang and Lu Yu and Long Wang and An-Guo Wu and Jian-Ming Wu and Xiao-Gang Zhou}, doi = {10.1002/advs.202416559}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416559}, shortjournal = {Adv. Sci.}, title = {Inhibition of ferroptosis delays aging and extends healthspan across multiple species}, volume = {12}, year = {2025}, }
• (2025). Low thermal conductivity in single crystalline Mg3Bi2 and its thermopower enhanced by electron-phonon interaction. ADVS, 12(22), 2416518. (www)

  @article{ , abstract = {Promising thermoelectric materials are usually those of “phonon-glass electron-crystal” (PGEC) compounds, with low thermal conductivity and high carrier mobility. In metallic materials, strong electron-phonon interaction usually causes an increase of Seebeck coefficient ( S ) at low temperature, due to an extra electrical current driven by heat-carrying phonons, named phonon drag effect. Here, this study reports that single crystalline metallic Mg 3 Bi 2 has low lattice thermal conductivity of ≈0.49 W m −1 K −1 at 285 K, and corresponding mean free path of phonons ( L ph ) is ≈0.48 nm, with carrier mobility of ≈54.2 cm 2 V −1 s −1 around room temperature. It is found that S exhibits an increase as a “hump” ≈20 K, and phonon drag effect ( S ph ) contributes to ≈80%, significantly higher than diffusive electrons. Meanwhile, S ph is positively proportional to L ph , where coefficient of S ph / L ph is ≈4.6 × 10 2 µV K −1 µm −1 , twice that of CrSb 2 and FeSb 2 , and relative strength of electron-phonon interaction is ≈0.12. The L ph -intercept of S ph / L ph approaches to ≈4.68 nm, where phonons can be strongly scattered before interacting with electrons, leading to a negligible phonon drag effect. The findings shed light on fundamental understanding of thermoelectric transport and exploring novel thermoelectric materials.}, archive = {J_ADVS}, author = {Qiang Feng and Jiayi He and Wenyang Wang and Huili Liu}, doi = {10.1002/advs.202416518}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416518}, shortjournal = {Adv. Sci.}, title = {Low thermal conductivity in single crystalline Mg3Bi2 and its thermopower enhanced by electron-phonon interaction}, volume = {12}, year = {2025}, }
• (2025). Resilient and flexible electrohydrodynamics pumps for Human–Machine interfaces. ADVS, 12(22), 2416502. (www)

  @article{ , abstract = {Soft fluidic systems can be a versatile tool to design human–machine interfaces such as hydraulic actuators, liquid displays, and thermal haptics. Yet the bulkiness, noise, and rigidity of pumps and valves required for fluid circulation prevent their use in flexible and portable devices. This study introduces an electrohydrodynamic (EHD) driven flexible pump with resilience against dielectric breakdown. Previous EHD pumps, despite their excellent features such as quietness and high power density, suffer from dielectric breakdowns and subsequent permanent failures. This pump with novel electrode construction has the passive resilience to recover the insulation essential for EHD without any external input in the event of dielectric breakdown. The passive resilience of our pump is demonstrated in various scenarios. Notably, this pump withstands 100 dielectric breakdowns and maintains 90% of its performance. An active resilient system is also configured to enable continuous pumping. This system automatically removes bubbles and other impurities to recover flow generation. This pumps drive various soft fluid-driven human-machine interfaces like soft actuators, prosthetic hands, and tube-format displays. The combination of passive resilience inherent in the pump and active resilience configured by the system ensures adaptability and robustness, setting the stage for the next generation of human–machine interfaces.}, archive = {J_ADVS}, author = {Yu Kuwajima and Amr Marzuq and Soraya Segawa and Yuya Yamaguchi and Yuhei Yamada and Takafumi Morita and Katrene Morozov and Haruto Iwasaki and Sota Suzuki and Hiroyuki Nabae and Vito Cacucciolo and Naoki Hosoya and Yasuaki Kakehi and Shingo Maeda}, doi = {10.1002/advs.202416502}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416502}, shortjournal = {Adv. Sci.}, title = {Resilient and flexible electrohydrodynamics pumps for Human–Machine interfaces}, volume = {12}, year = {2025}, }
• (2025). DNA molecular computing with weighted signal amplification for cancer miRNA biomarker diagnostics. ADVS, 12(22), 2416490. (www)

  @article{ , abstract = {The expression levels of microRNAs (miRNAs) are strongly linked to cancer progression, making them promising biomarkers for cancer detection. Enzyme-free signal amplification DNA circuits have facilitated the detection of low-abundance miRNAs. However, these methods may neglect the diagnostic value (or weight) of different miRNAs. Here, a molecular computing approach with weighted signal amplification is presented. Polymerase-mediated strand displacement is employed to assign weights to target miRNAs, reflecting the miRNAs’ diagnostic values, followed by amplification of the weighted signals using localized DNA catalytic hairpin assembly. This method is applied to diagnose miRNAs for non-small cell lung cancer (NSCLC). Machine learning is used to identify NSCLC-specific miRNAs and assign corresponding weights for optimum classification of healthy and lung cancer individuals. With the molecular computing of the miRNAs, the diagnostic output is simplified as a single channel of fluorescence intensity. Cancer tissues ( n = 18) and adjacent cancer tissues ( n = 10) are successfully classified within 2.5 h (sample-to-result) with an accuracy of 92.86%. The weighted amplification strategy has the potential to extend to the digital detection of multidimensional biomarkers, advancing personalized disease diagnostics in point-of-care settings.}, archive = {J_ADVS}, author = {Hongyang Zhao and Yumin Yan and Linghao Zhang and Xin Li and Lan Jia and Liang Ma and Xin Su}, doi = {10.1002/advs.202416490}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416490}, shortjournal = {Adv. Sci.}, title = {DNA molecular computing with weighted signal amplification for cancer miRNA biomarker diagnostics}, volume = {12}, year = {2025}, }
• (2025). Preparation and insight of [010]-orientated BiVO4 planar photoanode via one-step pyrolysis for significantly promoted charge separation and water oxidation. ADVS, 12(22), 2416474. (www)

  @article{ , abstract = {Preparation of planar bismuth vanadate (BiVO 4 , BVO) photoanode has inspired continuous interest due to its simple preparation and easy scalability, but its efficiency is still retarded by the poor bulk charge separation. Herein, BVO photoanode is successfully prepared with a preferential [010] orientation (denoted as [010]-BVO) grown on fluorine-doped tin oxide (FTO) through one simple pyrolysis method for the first time, which exhibits over 21 times of higher photocurrent density of water oxidation with respect to the randomly orientated BVO (denoted as R-BVO). Strikingly, the orientated BVO photoanode shows an exceptional charge separation efficiency of 97.5% at 1.23 V versus the reference hydrogen electrode (RHE) and a theoretical applied bias photon-to-current efficiency (ABPE) value of 2.1% at 0.67 V versus RHE. It is unraveled that the significantly increased carrier transport and collection along the [010] direction should be mainly responsible for the unexpectedly efficient charge separation as well as photoelectrochemical performance. The development of orientated growth planar BVO photoanode may pave the way for designing high-performance photoanodes for large-scale solar-to-chemical conversion.}, archive = {J_ADVS}, author = {Sainan Zhang and Jiaming Zhang and Nengcong Yang and Yejun Xiao and Rong Wang and Yunfeng Bao and Guijun Ma and Shengye Jin and Fuxiang Zhang}, doi = {10.1002/advs.202416474}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416474}, shortjournal = {Adv. Sci.}, title = {Preparation and insight of [010]-orientated BiVO4 planar photoanode via one-step pyrolysis for significantly promoted charge separation and water oxidation}, volume = {12}, year = {2025}, }
• (2025). COPS5 triggers ferroptosis defense by stabilizing MK2 in hepatocellular carcinoma. ADVS, 12(22), 2416360. (www)

  @article{ , abstract = {Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as a first-line treatment for patients with advanced hepatocellular carcinoma (HCC), but it has limited clinical benefits, mainly due to drug resistance. Herein, using genome-wide CRISPR/Cas9 knockout screening and multiple functional studies, this work identifies COP9 signalosome subunit 5 (COPS5) as a driver of sorafenib resistance and a suppressor of ferroptosis in HCC. Consistently, the amplification and overexpression of COPS5 are frequently observed in clinical HCC samples, which are associated with poor patient prognosis and might predict patient response to sorafenib therapy. Mechanistically, COPS5 stabilized mitogen-activated protein kinase 2 (MK2) through deubiquitination and, in turn, induced the activation of heat shock protein beta-1 (HSPB1), a ferroptosis repressor, thereby protecting HCC cells from ferroptosis and consequently leading to sorafenib resistance and tumor progression, while its own expression could be induced by sorafenib treatment via activating transcription factor 4 (ATF4)-activated transcription. Furthermore, pharmacological inhibition of COPS5/MK2 synergize with sorafenib to induce ferroptosis and suppress HCC progression. This data reveals the crucial role of COPS5 in triggering ferroptosis defense and sorafenib resistance through the activation of the MK2-HSPB1 axis in HCC and highlights the potential of targeting COPS5/MK2 combined with sorafenib as a promising strategy for treating HCC.}, archive = {J_ADVS}, author = {Ai-Ling Luo and Wen-Ying Zheng and Qiong Zhang and Yan Yuan and Mei-Qi Li and Kai Du and An-Ran Gao and Li-Jun Pei and Jie Xie and Wen-Hao Chen and Long Zhang and Xiu-Zhu Guo and Xiao-Ran Yang and Chao Zeng and Guo-Hua Yang and Min Deng}, doi = {10.1002/advs.202416360}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416360}, shortjournal = {Adv. Sci.}, title = {COPS5 triggers ferroptosis defense by stabilizing MK2 in hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Upscaling perovskite photovoltaics: From 156 cm2 modules to 0.73 m2 panels. ADVS, 12(22), 2416316. (www)

  @article{ , abstract = {This study tackles the challenge of upscaling perovskite solar modules (PSMs) to attain high power conversion efficiencies (PCEs) suitable for industrial applications. Through systematic experimentation, a remarkable PCE of 17.68% for PSMs fabricated on a substrate with dimensions of 15.6 cm×15.6 cm is achieved. By refining the cell interconnection design, a geometric fill factor (GFF) of 96.4% is obtained, marking a significant milestone in bridging the performance gap between individual cells and modules. Building on this success, it is fabricated and tested large-area perovskite solar panels (PSPs) with an area of 0.73 m 2 , integrating the optimized PSMs. This work not only demonstrates the feasibility of large-scale perovskite-based photovoltaic systems but also sets a new benchmark for the PCE and scalability of these technologies, paving the way for their practical application in renewable energy generation.}, archive = {J_ADVS}, author = {Hafez Nikbakht and Paolo Mariani and Luigi Vesce and Francesco Di Giacomo and Enrico Leonardi and George Viskadouros and Emmanuel Spiliarotis and Konstantinos Rogdakis and Sara Pescetelli and Antonio Agresti and Sebastiano Bellani and Francesco Bonaccorso and Emmanuel Kymakis and Aldo Di Carlo}, doi = {10.1002/advs.202416316}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416316}, shortjournal = {Adv. Sci.}, title = {Upscaling perovskite photovoltaics: From 156 cm2 modules to 0.73 m2 panels}, volume = {12}, year = {2025}, }
• (2025). Exercise without weight loss prevents seasonal decline in vitamin d metabolites: The VitaDEx randomized controlled trial. ADVS, 12(22), 2416312. (www)

  @article{ , abstract = {Many adults become vitamin D deficient or insufficient during winter at northerly latitudes when cutaneous vitamin D synthesis does not occur. Vitamin D accumulates in adipose tissue and people with overweight or obesity are more likely to have low systemic vitamin D. This randomized controlled trial demonstrates that regular exercise completely maintains serum concentrations of the active vitamin D metabolite 1,25(OH) 2 D 3 over winter and may ameliorate the decline in 25(OH)D status in overweight men and women, even without weight loss. The binding of 1,25(OH) 2 D 3 to the vitamin D receptor mediates the crucial role for vitamin D in the healthy function of multiple organ systems and vitamin D supplementation does not impact circulating 1,25(OH) 2 D 3 . Thus, the VitaDEx study provides causal evidence that exercise plays an important role in vitamin D metabolism that is distinct from the effects of oral supplementation.}, archive = {J_ADVS}, author = {Oliver J. Perkin and Sophie E. Davies and Martin Hewison and Kerry S. Jones and Javier T. Gonzalez and James A. Betts and Carl Jenkinson and Mark A. Lindsay and Sarah R. Meadows and Damon A. Parkington and Albert Koulman and Dylan Thompson}, doi = {10.1002/advs.202416312}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416312}, shortjournal = {Adv. Sci.}, title = {Exercise without weight loss prevents seasonal decline in vitamin d metabolites: The VitaDEx randomized controlled trial}, volume = {12}, year = {2025}, }
• (2025). Residual stresses and micro-voids propel metal diffusion for filament-based memristors. ADVS, 12(22), 2416305. (www)

  @article{ , abstract = {Metal filamentation based mechanisms have the advantage of a high switching current ratio, yet typically require high switching voltages to activate the memristive device due to the primary mechanism of atomic vacancy filling and movement. Herein, Introducing non-reactive nitrogen gas during plasma sputtering of silver is shown to prime the overlying metal nitride layer to achieve low threshold switching at applied biases of below 60 millivolts. Residual nitrogen species within the silver under-layer promote the creation of nano-sized void defects within the superjacent dielectric layer, which, coupled with residual stresses in the gigapascal range, enable sub-micron filamentation growth. These memristor devices function similarly to potassium ion channels, displaying current growth and relaxation patterns that align with the Hodgkin-Huxley model, and as such are amenable to the development of artificial neuron structures. Further, a diverse set of neuromorphic behaviors not seen within typical metal filamentation based memristors is observed. This includes multi-peak synaptic weight changes in the device's response to spiked stimuli. Both the switching voltages and neuromorphic properties are linked to the nitrogen-argon pressure during silver deposition. Interestingly, these devices also exhibit lateral growth of silver filamentation across the surface of the metal nitride thin film layer with gaps of more than a hundred micrometers, suggesting that the underlying silver undergoes accumulation and breakthrough. The filling of large micro-voids with Ag generates large nanoparticles that easily propagate, enabling a large diffusion front and faster filamentation time, whereas small micro-voids create a bottleneck in the filamentation process. Additionally, the introduction of residual stresses in conventional diffusion theory indicates greater dendritic interconnectivity and thus electrode to electrode connection. This study demonstrates that the facile incorporation of non-reactive gases during the sputter-deposition of a metal electrode opens a path to unique material mechanisms that facilitate the development of versatile memristors.}, archive = {J_ADVS}, author = {Joel Y.Y. Loh and Jason Yuan and Samuel Moor-Smith and Adam Glustein and Gloria Vytas and Will Taylor and Andres Lombo and Richard J. Curry and Nazir Pyarali Kherani}, doi = {10.1002/advs.202416305}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416305}, shortjournal = {Adv. Sci.}, title = {Residual stresses and micro-voids propel metal diffusion for filament-based memristors}, volume = {12}, year = {2025}, }
• (2025). Metal–Organic frameworks: Unlocking new frontiers in cardiovascular diagnosis and therapy. ADVS, 12(22), 2416302. (www)

  @article{ , abstract = {Cardiovascular disease (CVD) is one of the most critical diseases which is the predominant cause of death in the world. Early screening and diagnosis of the disease and effective treatment after diagnosis play an important role in the patient's recovery. Metal–organic frameworks (MOFs), a kind of hybrid ordered micro or meso-porous materials, constructed by metal nodes or clusters with organic ligands, due to their special features like high porosity and specific surface area, open metal sites, or ligand tunability, are widely used in various areas including gas storage, catalysis, sensors, biomedicine. Recently, advances in MOFs are bringing new developments and opportunities for the healthcare industry including the theranostic of CVD. In this review, the applications of MOFs are illustrated in the diagnosis and therapy of CVD, including biomarker detection, imaging, drug delivery systems, therapeutic gas delivery platforms, and nanomedicine. Also, the toxicity and biocompatibility of MOFs are discussed. By providing a comprehensive summary of the role played by MOFs in the diagnosis and treatment of CVDs, it is hoped to promote the future applications of MOFs in disease theranostics, especially in CVDs.}, archive = {J_ADVS}, author = {Qilu Wu and Yuxiao Feng and Mathilde Lepoitevin and Meng Yu and Christian Serre and Jun Ge and Yuan Huang}, doi = {10.1002/advs.202416302}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416302}, shortjournal = {Adv. Sci.}, title = {Metal–Organic frameworks: Unlocking new frontiers in cardiovascular diagnosis and therapy}, volume = {12}, year = {2025}, }
• (2025). Engineering light-element modified LaFe11.6Si1.4 compounds enables tunable giant magnetocaloric effect. ADVS, 12(22), 2416288. (www)

  @article{ , abstract = {Magnetocaloric refrigeration is one of the most promising next-generation solid-state caloric techniques to revolutionize the traditional air-compression technique. The La(Fe,Si) 13 -based materials are recognized as candidates with potential for practical applications. However, flexible strategies to improve the Curie temperature ( T C ) and further achieve the tunable giant magnetocaloric effect (GMCE) still need to be developed. Here, the systematic experimental investigation on a series of light elements (C, F, S) modified LaFe 11.6 Si 1.4 compounds are presented. It is found that all modified samples exhibit a higher T C , with a negligible impact on the thermal hysteresis. The GMCE performance in C- and S-modified samples is significantly degraded, but the maximum magnetic entropy change | Δ s m | for the optimally doped F sample can be well maintained at 19.2 J kg −1 K −1 for a field change of 2 T. The preferential site occupancy of dopants is determined, and the microstructural observation and metastable atomic changes have also been analyzed. It is concluded that interstitial doping is more efficient to shift T C . The first-order transition can however not be maintained upon doping due to changes in the hybridization. These findings highlight the importance of the interplay between the lattice pressure effect and the covalent hybridization for this material family.}, archive = {J_ADVS}, author = {Fengqi Zhang and Ziying Wu and Xiaofang Zhang and Xiang Chi and Zhenduo Wu and Jianrong Gao and Huaican Chen and Wen Yin and Ulrich Lienert and Ann-Christin Dippel and Martin v. Zimmermann and Niels van Dijk and Ekkes Brück and Yang Ren}, doi = {10.1002/advs.202416288}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416288}, shortjournal = {Adv. Sci.}, title = {Engineering light-element modified LaFe11.6Si1.4 compounds enables tunable giant magnetocaloric effect}, volume = {12}, year = {2025}, }
• (2025). Model-guided rational construction of escherichia coli synthetic consortia for enhanced 2-methylbutyric acid production. ADVS, 12(22), 2416272. (www)

  @article{ , abstract = {Synthetic consortia represent an innovative and effective platform that can significantly alleviate the metabolic burden on host organisms and enable flexible regulation of biosynthetic pathways. However, designing a stable synthetic consortium remains a significant challenge. In this study, a novel citramalate -derived pathway is first developed for 2-methylbutyric acid (2MBA) biosynthesis in an E. coli mono-culture system, achieving a titer of 678.78 ± 49.04 mg L −1 . Furthermore, it employs a CulECpy model-guided strategy to design and optimize the division of labor within E. coli synthetic consortia, predicting the optimal pathway allocation for improved 2MBA production. The best-performing consortium, using 2-keto-3-methylvalerate (KMV) as a single node, achieved 1817.03 ± 103.73 mg L −1 of 2MBA, a 28-fold increase over the initial mono-culture strain, with the highest reported yield of 0.091 g/g glucose. This work demonstrates the effectiveness of synthetic consortia and model-guided pathway optimization for improving high-value products, a versatile strategy that can be applied to the production of other valuable metabolites.}, archive = {J_ADVS}, author = {Yu Liu and Boyuan Xue and Shaojie Wang and Haijia Su}, doi = {10.1002/advs.202416272}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416272}, shortjournal = {Adv. Sci.}, title = {Model-guided rational construction of escherichia coli synthetic consortia for enhanced 2-methylbutyric acid production}, volume = {12}, year = {2025}, }
• (2025). Shape-selective molecular separations enabled by rigid and interconnected confinements engineered in conjugated microporous polymer membranes. ADVS, 12(22), 2416266. (www)

  @article{ , abstract = {Separating molecules with similar sizes but different shapes is essential yet challenging. Here, conjugated microporous polymer (CMP) membranes with narrowly distributed network pores are prepared by diffusion-modulated electropolymerization. This approach precisely controls the monomer diffusion and coupling processes, regulating the crosslinking degree to prevent broad aggregate pores and microporous defects. By altering carbazole-based backbones, pore size and pore connectivity are adjusted. The rigid and interconnected confinements restrict molecular rotation and vibration, enforcing consistent shapes and orientations. This enables the separation of solute molecules (≈1000 g mol −1 ) with linear and bulky shapes, achieving separation factors of up to 134. When pore size is reduced to angstrom scale (≈5 Å), molecular shape significantly influences organic liquid transport. The CMP membranes demonstrate all-liquid phase separation of linear/branched alkane isomers (<100 g mol −1 ), enriching hexane to 63.35 mole% from equimolar isomer mixture and achieving permeance orders of magnitude higher than those of state-of-the-art membranes.}, archive = {J_ADVS}, author = {Yanqiu Lu and Hao Deng and Liling Zhang and Yong Wang and Sui Zhang}, doi = {10.1002/advs.202416266}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416266}, shortjournal = {Adv. Sci.}, title = {Shape-selective molecular separations enabled by rigid and interconnected confinements engineered in conjugated microporous polymer membranes}, volume = {12}, year = {2025}, }
• (2025). One-pot synthesis of chiral succinate dehydrogenase inhibitors and antifungal activity studies. ADVS, 12(22), 2416250. (www)

  @article{ , abstract = {In this work, a series of novel chiral succinate dehydrogenase inhibitors (SDHIs) are synthesized through a one-pot Rh-catalyzed asymmetric hydrogenation-condensation strategy. This method exhibits high efficiency (up to 1000 Ton, 94% yield over two steps), high stereoselectivity (up to 99% ee), and broad substrate scope (68 examples in total), providing a superior pathway for the synthesis of such chiral fungicides. Mechanistic studies indicate that the amino group at the 2-position of the phenyl ring acts as an activating group, enhancing the reactivity and stereoselectivity control of the reaction. Furthermore, these molecules exhibit broad-spectrum and highly effective antifungal biological activity. Notably, enantiomers show significant differences in both in vitro and in vivo fungi-inhibiting experiments. Especially, ( S )- 5f showcases an antifungal activity against Botrytis cinerea (EC 50 = 0.48 µ m ) that is much higher than that of its R enantiomer (EC 50 = 36.7 µ m ). Molecular docking calculations, molecular dynamic simulation, enzyme activity assays, and ligand-target interaction experiments demonstrate that ( S )- 5f (ΔG MM-PBSA = −18.86 kcal mol −1 , K D = 6.04 µ m ) inhibits succinate dehydrogenase more effectively than its R enantiomer (ΔG MM-PBSA = −13.01 kcal mol −1 , K D = 8.5 µ m ). Moreover, the two enantiomers have significantly different effects on spore germination and the destruction of fungal phenotype.}, archive = {J_ADVS}, author = {Donghua Du and Yu Chen and Chengbing Yang and Zheng Jin and Huailong Teng}, doi = {10.1002/advs.202416250}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416250}, shortjournal = {Adv. Sci.}, title = {One-pot synthesis of chiral succinate dehydrogenase inhibitors and antifungal activity studies}, volume = {12}, year = {2025}, }
• (2025). Tuning aggregation in liquid-crystalline squaraine chromophores. ADVS, 12(22), 2416249. (www)

  @article{ , abstract = {For a series of novel hydroxy anilino squaraines (SQ), separated via short flexible spacers from bulky dendrons, hexagonal columnar (Col hex ) liquid-crystalline (LC) phase behavior is detected. The optical properties of these SQ systems, designed for melting below 80 °C, very low for SQ systems, are found to be determined by the LC structures which in turn are governed by volume and steric effects of the dendrons affecting the temperature-dependent interplay between monomeric species and H-aggregates in the LC state, ultimately responsible for the optical properties. Experimental results are corroborated by self-consistent field theory (SCFT) as well as time-dependent density functional theory calculations (TD-DFT). The results demonstrate a new strategy for dynamically tuning aggregates and optical properties for the prescriptive functionalization of the LC SQ materials and with potential for other aggregating systems.}, archive = {J_ADVS}, author = {Tianyi Tan and Yu Cao and Changlong Chen and Sanliang Ling and Gaolei Hou and Martin J. Paterson and Xin Wang and Ying Chen and Kai Jiang and Gang He and Goran Ungar and Georg H. Mehl and Feng Liu}, doi = {10.1002/advs.202416249}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416249}, shortjournal = {Adv. Sci.}, title = {Tuning aggregation in liquid-crystalline squaraine chromophores}, volume = {12}, year = {2025}, }
• (2025). IRF8 drives conventional type 1 dendritic cell differentiation and CD8+ t cell activation to aggravate abdominal aortic aneurysm development. ADVS, 12(22), 2416238. (www)

  @article{ , abstract = {Abdominal aortic aneurysm (AAA) is the most common true aneurysm worldwide, and recent studies suggest that dendritic cells (DCs) play a key role in its development, though the specific subtypes and underlying mechanisms remain unclear. In this study, the role of interferon regulatory factor 8 (IRF8) in AAA is investigated by focusing on its effect on the differentiation of DC precursors into conventional type 1 dendritic cells (cDC1s). It is found significant infiltration of HLA-DR + IRF8 + cells in human AAA tissue samples. In mice, DC-specific overexpression of Irf8 exacerbates aneurysm expansion following periadventitial elastase application, while DC-specific Irf8 deletion attenuates AAA development. Batf3 −/− mice, which lack cDC1s, exhibit AAA characteristics similar to the Irf8 -deleted mice. Additionally, an increased population of activated CD8 + T cells is observed in the DC- Irf8 overexpressed mice, while the DC- Irf8 deletion mice show a decrease in these cells. Blocking antigen cross-presentation to CD8 + T cells also reduces AAA progression. Tissue microarray analysis of human aortic samples further confirms a correlation between IRF8 expression and AAA development. These findings suggest that IRF8 activation promotes cDC1 differentiation, leading to the recruitment of CD8 + T cells, which contribute to aortic wall destruction and AAA formation.}, archive = {J_ADVS}, author = {Zhen Yuan and Li Shu and Yidan Zheng and Yidong Wang and Mengsha Zheng and Jie Sun and Jiantao Fu and Zihao Zhou and Shen Song and Zhenjie Liu and Fei Li and Zhejun Cai}, doi = {10.1002/advs.202416238}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416238}, shortjournal = {Adv. Sci.}, title = {IRF8 drives conventional type 1 dendritic cell differentiation and CD8+ t cell activation to aggravate abdominal aortic aneurysm development}, volume = {12}, year = {2025}, }
• (2025). Non-invasive tumor budding evaluation and correlation with treatment response in bladder cancer: A multi-center cohort study. ADVS, 12(22), 2416161. (www)

  @article{ , abstract = {The clinical benefits of neoadjuvant chemoimmunotherapy (NACI) are demonstrated in patients with bladder cancer (BCa); however, more than half fail to achieve a pathological complete response (pCR). This study utilizes multi-center cohorts of 2322 patients with pathologically diagnosed BCa, collected between January 1, 2014, and December 31, 2023, to explore the correlation between tumor budding (TB) status and NACI response and disease prognosis. A deep learning model is developed to noninvasively evaluate TB status based on CT images. The deep learning model accurately predicts the TB status, with area under the curve values of 0.932 (95% confidence interval: 0.898–0.965) in the training cohort, 0.944 (0.897–0.991) in the internal validation cohort, 0.882 (0.832–0.933) in external validation cohort 1, 0.944 (0.908–0.981) in the external validation cohort 2, and 0.854 (0.739–0.970) in the NACI validation cohort. Patients predicted to have a high TB status exhibit a worse prognosis ( p < 0.05) and a lower pCR rate of 25.9% (7/20) than those predicted to have a low TB status (pCR rate: 73.9% [17/23]; p < 0.001). Hence, this model may be a reliable, noninvasive tool for predicting TB status, aiding clinicians in prognosis assessment and NACI strategy formulation.}, archive = {J_ADVS}, author = {Xiaoyang Li and Chen Zou and Chunhui Wang and Cheng Chang and Yi Lin and Shuai Liang and Haoran Zheng and Libo Liu and Kai Deng and Lin Zhang and Bohao Liu and Mingchao Gao and Peicong Cai and Jianwen Lao and Longhao Xu and Daqin Wu and Xiao Zhao and Xiao Wu and Xinyuan Li and Yun Luo and Wenlong Zhong and Tianxin Lin}, doi = {10.1002/advs.202416161}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2416161}, shortjournal = {Adv. Sci.}, title = {Non-invasive tumor budding evaluation and correlation with treatment response in bladder cancer: A multi-center cohort study}, volume = {12}, year = {2025}, }
• (2025). Unraveling neurodevelopment: Synergistic effects of intrinsic genetic programs and extrinsic environmental cues. ADVS, 12(22), 2414890. (www)

  @article{ , abstract = {The development of the brain involves the proliferation of neural stem cells (NSCs) and the differentiation of neurogenic cells, including neurons, astrocytes, and oligodendrocytes. The growth and development of other cells in the brain, including microglia and blood vessels, are also crucial for maintaining normal brain function. In the first part, the intrinsic regulatory mechanisms of NSCs during neurogenesis are primarily delved into. This focused on the effects of epigenetic modifications on the proliferation and differentiation of NSCs. Additionally, the phenomenon where their own proliferative behavior leads to the activation of immune-related genes are discussed. Furthermore, the impact of maternal immune activation on neurogenesis are explored. Finally, the reasons underlying differences in brain development between humans and mice are examined. In the second part, the development and origin of microglia, their heterogeneity during the developmental process, and the impact of microglia on the development of surrounding cells are delved into. In the third part, the relationship between the cerebrovascular system and brain development are explored. This includes the communication and interaction between blood vessels and NSCs, as well as the effects of cytokines secreted by blood vessels on synapses and the genesis of glial cells.}, archive = {J_ADVS}, author = {Yanyan Wang and Shukui Zhang and Huiyang Jia and Fen Ji and Jianwei Jiao}, doi = {10.1002/advs.202414890}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2414890}, shortjournal = {Adv. Sci.}, title = {Unraveling neurodevelopment: Synergistic effects of intrinsic genetic programs and extrinsic environmental cues}, volume = {12}, year = {2025}, }
• (2025). Rational design of MOF-based multifunctional bio-nanoreactor for efficient detection and photo-degradation of chloramphenicol. ADVS, 12(22), 2414866. (www)

  @article{ , abstract = {Food safety have received increasing attention in recent years, and rapid detection and thorough removal of organic contaminants is an important part of food safety control. In this work, a novel multi-functional photo-enzymatic nanoreactor HRP@Fe-NU-1003 is developed through the co-immobilization of horseradish peroxidase (HRP) and FeCl 2 on a photosensitive metal–organic frameworks (MOF) NU-1003. The bio-nanocluster can serve as an efficient biosensor in the detection of chloramphenicol (CAP), with a detection limit of 15.38 pg mL −1 , which is 62 times greater than that of the conventional HRP- enzyme-linked immunosorbent assay method. Besides its detecting capability, the nanoreactor also exhibits high efficiency in the photocatalytic degradation of CAP, which can remove 50 µg mL −1 of CAP thoroughly within 30 min, and the mineralization efficiency of CAP reaches 61%. In this material, Fe-NU-1003 not only acts as a protecting shell to prevent HRP from deactivation, but improves detecting sensitivity and photocatalytic performance. Mechanism studies show that FeCl 2 enhances its photocatalytic performance through promoting electron (e − )–hole (h + ) separation and photocurrent transfer. More importantly, the heterogeneous material possesses high stability and can be recycled at least five rounds while its photocatalytic performance maintained at a high level. This strategy provides a new approach for the detection and degradation of pollutants.}, archive = {J_ADVS}, author = {Lu Ran and Niu Feng and Yiming Dong and Huanyu Cai and Yiping Chen and Huailong Teng}, doi = {10.1002/advs.202414866}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2414866}, shortjournal = {Adv. Sci.}, title = {Rational design of MOF-based multifunctional bio-nanoreactor for efficient detection and photo-degradation of chloramphenicol}, volume = {12}, year = {2025}, }
• (2025). Area-selective atomic layer deposition on homogeneous substrate for next-generation electronic devices. ADVS, 12(22), 2414483. (www)

  @article{ , abstract = {Area-selective atomic layer deposition (AS-ALD) has focused on controlling the promotion or blocking of precursor molecules on “ heterogeneous ” surfaces comprising different materials. This study proposes a new concept of AS-ALD on “ homogeneous ” surfaces comprising a single material. In this work, a homogeneous ZrO 2 substrate is selectively fluorinated using sulfur hexafluoride (SF 6 ) gas. The SF 6 decomposes and incorporates into oxygen vacancies in ZrO 2 , forming F-terminated surface at grain boundaries (GBs). In the following step, the remaining hydroxyl-terminated ZrO 2 areas are blocked by a cyclopentadienyl ligand to prevent aluminum precursor adsorption. Density functional theory and Monte Carlo simulations show that selectively passivated GBs of ZrO 2 lead to the selective adsorption of ZrCp(NMe 2 ) 3 inhibitors. Selective growth of Al 2 O 3 along GBs of ZrO 2 is observed by elemental mapping from transmission electron microscopy. Finally, GB-selective Al 2 O 3 increases overalldielectric constant by 15.5% in ZrO 2 /Al 2 O 3 /ZrO 2 stacks with no increase in leakage currents, showing that the GB-selective Al 2 O 3 incorporation suffices to passivate leakage paths through ZrO 2 GBs. These findings provide fundamental guidelines for performing AS-ALD on homogeneous surfaces and highlight the potential of this approach for applications in next-generation electronic devices.}, archive = {J_ADVS}, author = {Min-Jeong Rhee and Byoungjun Won and Young-Jin Lim and Jeong-Gyu Song and Sunghyun Kim and Il-Kwon Oh}, doi = {10.1002/advs.202414483}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2414483}, shortjournal = {Adv. Sci.}, title = {Area-selective atomic layer deposition on homogeneous substrate for next-generation electronic devices}, volume = {12}, year = {2025}, }
• (2025). Label-free dual-modal Photoacoustic/Ultrasound localization imaging for studying acute kidney injury. ADVS, 12(22), 2414306. (www)

  @article{ , abstract = {Growing evidence suggests a close link between acute kidney injury (AKI) and disruptions in renal microcirculation. However, current non-invasive tools for quantitatively monitoring structural and functional changes in renal microcirculation remain limited, making early diagnosis difficult. To address this challenge, this work introduces a label-free 3D multi-parametric imaging technique that combines photoacoustic and super-resolution ultrasound imaging. This approach provides high-resolution information on renal vasculature, hemodynamics, and oxygenation. This system offers the ability to visualize the entire renal vasculature at a resolution of 26 µm. In an AKI model, this work demonstrates a 54% reduction in vascular density, a 14.1% decrease in renal oxygenation, and a 61% decline in relative blood volume (rBV) 3 days post-surgery. The progression of kidney disease is further confirmed through blood tests and histopathological analysis of the collected kidney tissues. These findings indicate that this 3D renal imaging technique holds substantial potential to advance the understanding of renal physiology and offers a valuable tool for investigating renal injury.}, archive = {J_ADVS}, author = {Shensheng Zhao and Xingxing Zhang and Keith Bailey and Sathvik Pai and Yang Zhao and Yun-Sheng Chen}, doi = {10.1002/advs.202414306}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2414306}, shortjournal = {Adv. Sci.}, title = {Label-free dual-modal Photoacoustic/Ultrasound localization imaging for studying acute kidney injury}, volume = {12}, year = {2025}, }
• (2025). Comparison of large language model with aphasia. ADVS, 12(22), 2414016. (www)

  @article{ , abstract = {Large language models (LLMs) respond fluently but often inaccurately, which resembles aphasia in humans. Does this behavioral similarity indicate any resemblance in internal information processing between LLMs and aphasic humans? Here, we address this question by comparing the network dynamics between LLMs—ALBERT, GPT-2, Llama-3.1 and one Japanese variant of Llama—and various aphasic brains. Using energy landscape analysis, we quantify how frequently the network activity pattern is likely to move from one state to another (transition frequency) and how long it tends to dwell in each state (dwelling time). First, by investigating the frequency spectrums of these two indices for brain dynamics, we find that the degrees of the polarization of the transition frequency and dwelling time enable accurate classification of receptive aphasia, expressive aphasia and controls: receptive aphasia shows the bimodal distributions for both indices, whereas expressive aphasia exhibits the most uniform distributions. In parallel, we identify highly polarized distributions in both transition frequency and dwelling time in the network dynamics in the four LLMs. These findings indicate the similarity in internal information processing between LLMs and receptive aphasia, and the current approach can provide a novel diagnosis and classification tool for LLMs and help their performance improve.}, archive = {J_ADVS}, author = {Takamitsu Watanabe and Katsuma Inoue and Yasuo Kuniyoshi and Kohei Nakajima and Kazuyuki Aihara}, doi = {10.1002/advs.202414016}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2414016}, shortjournal = {Adv. Sci.}, title = {Comparison of large language model with aphasia}, volume = {12}, year = {2025}, }
• (2025). Single-cell atlas reveals tumorigenic profiles and immune dynamics of adrenal incidentalomas. ADVS, 12(22), 2413493. (www)

  @article{ , abstract = {Adrenal incidentalomas (AIs) are commonly detected endocrine lesions, identified during imaging for unrelated conditions. These lesions exhibit considerable heterogeneity and diverse clinical outcomes. This study employed single-cell RNA sequencing to investigate tumorigenic characteristics of AIs, including non-functional adrenocortical adenomas, Conn's syndrome, and pheochromocytomas. Through integrating public datasets, 302 696 cells are analyzed. Three adrenocortical cell subtypes exhibit gene expression patterns linked to tumorigenesis. Clusterin emerges as a potential biomarker for adrenocortical adenomas. Adrenocortical tumor cells show dysregulated hormone secretion and transcription factor steroidogenic factor 1 (SF1) is significantly upregulated, distinguishing cortical from medullary tumors. In pheochromocytomas, a MYCN proto-oncogene (MYCN)-positive cluster correlates with poorer survival. Immune microenvironment analysis reveals specific immune subtypes and roles in tumor progression. Specifically, myeloid cells may regulate benign tumors, while lymphoid cells, such as CD8-positive (CD8+) T cells, appear to promote immune activation and infiltration in malignant tumors. Overall, this study enhances the understanding of adrenal adenoma heterogeneity, revealing crucial transcriptional profiles, immune interactions, and clinically relevant candidate biomarkers.}, archive = {J_ADVS}, author = {Meng Wang and Guangmin Zheng and Xiaoyong Hu and Feng Tian and Tuo Li and Zheng Zhang and Kan Gong and Shiwei Chen and Lin Yuan and Yu Qi and Lin Li and Daofu Cheng and Liu Liu and Fuqiang Liu and Yujing Sun and Xiangdong Fang and Ruxing Zhao and Bing Liu and Chao Zhang}, doi = {10.1002/advs.202413493}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2413493}, shortjournal = {Adv. Sci.}, title = {Single-cell atlas reveals tumorigenic profiles and immune dynamics of adrenal incidentalomas}, volume = {12}, year = {2025}, }
• (2025). Integrative multi-omics and routine blood analysis using deep learning: Cost-effective early prediction of chronic disease risks. ADVS, 12(22), 2412775. (www)

  @article{ , abstract = {Chronic noncommunicable diseases (NCDS) are often characterized by gradual onset and slow progression, but the difficulty in early prediction remains a substantial health challenge worldwide. This study aims to explore the interconnectedness of disease occurrence through multi-omics studies and validate it in large-scale electronic health records. In response, the research examined multi-omics data from 160 sub-healthy individuals at high altitude and then a deep learning model called Omicsformer is developed for detailed analysis and classification of routine blood samples. Omicsformer adeptly identified potential risks for nine diseases including cancer, cardiovascular conditions, and psychiatric conditions. Analysis of risk trajectories from 20 years of large clinical patients confirmed the validity of the group in preclinical risk assessment, revealing trends in increased disease risk at the time of onset. Additionally, a straightforward NCDs risk prediction system is developed, utilizing basic blood test results. This work highlights the role of multiomics analysis in the prediction of chronic disease risk, and the development and validation of predictive models based on blood routine results can help advance personalized medicine and reduce the cost of disease screening in the community.}, archive = {J_ADVS}, author = {Zhibin Dong and Pei Li and Yi Jiang and Zhihan Wang and Shihui Fu and Hebin Che and Meng Liu and Xiaojing Zhao and Chunlei Liu and Chenghui Zhao and Qin Zhong and Chongyou Rao and Siwei Wang and Suyuan Liu and Dayu Hu and Dongjin Wang and Juntao Gao and Kai Guo and Xinwang Liu and En Zhu and Kunlun He}, doi = {10.1002/advs.202412775}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2412775}, shortjournal = {Adv. Sci.}, title = {Integrative multi-omics and routine blood analysis using deep learning: Cost-effective early prediction of chronic disease risks}, volume = {12}, year = {2025}, }
• (2025). Histone lactylation antagonizes senescence and skeletal muscle aging by modulating aging-related pathways. ADVS, 12(22), 2412747. (www)

  @article{ , abstract = {Epigenetic alterations are among the prominent drivers of cellular senescence and/or aging, intricately orchestrating gene expression programs during these processes. This study shows that histone lactylation, plays a pivotal role in counteracting senescence and mitigating dysfunctions of skeletal muscle in aged mice. Mechanistically, histone lactylation and lactyl-CoA levels markedly decrease during cellular senescence but are restored under hypoxic conditions primarily due to elevated glycolytic activity. The enrichment of histone lactylation at promoters is essential for sustaining the expression of genes involved in the cell cycle and DNA repair pathways. Furthermore, the modulation of enzymes crucial for histone lactylation, leads to reduced histone lactylation and accelerated cellular senescence. Consistently, the suppression of glycolysis and the depletion of histone lactylation are also observed during skeletal muscle aging. Modulating the enzymes can also lead to the loss of histone lactylation in skeletal muscle, downregulating DNA repair and proteostasis pathways and accelerating muscle aging. Running exercise increases histone lactylation, which in turn upregulate key genes in the DNA repair and proteostasis pathways. This study highlights the significant roles of histone lactylation in modulating cellular senescence as well as muscle aging, providing a promising avenue for antiaging intervention via metabolic manipulation.}, archive = {J_ADVS}, author = {Fanju Meng and Jianuo He and Xuebin Zhang and Wencong Lyu and Ran Wei and Shiyi Wang and Zhehao Du and Haochen Wang and Jinlong Bi and Xueyang Hua and Chao Zhang and Yiting Guan and Guoliang Lyu and Xiao-Li Tian and Lijun Zhang and Wenbing Xie and Wei Tao}, doi = {10.1002/advs.202412747}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2412747}, shortjournal = {Adv. Sci.}, title = {Histone lactylation antagonizes senescence and skeletal muscle aging by modulating aging-related pathways}, volume = {12}, year = {2025}, }
• (2025). High fat low carbohydrate diet is linked to CNS autoimmunity protection. ADVS, 12(22), 2412236. (www)

  @article{ , abstract = {Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) believed to be driven by autoimmune mechanisms. Genetic and environmental factors are implicated in MS development, and among the latter, diets and nutrients are emerging as potential critical contributors. However, a comprehensive understanding of their impacts and the underlying mechanisms involved is lacking. Harnessing state-of-the-art nutritional geometry analytical methods, it is first revealed that globally, increased carbohydrate supply is associated with increased MS disease burden, while fat supply has an opposite effect. Furthermore, in a MS mouse model, experimental autoimmune encephalomyelitis (EAE), it is found that an isocaloric diet high in carbohydrate aggravated EAE, while a diet enriched in fat (HF) is fully protective. This is reflected by reduced neuroinflammation and skewing toward anti-inflammatory phenotypes. The protective effects from the HF diet are multifaceted. Metabolically, HF increased lipid storage in immune cells, correlating with their increased anti-inflammatory IL-10 production. Transcriptionally and epigenetically, HF feeding preprogrammed naïve T cells toward a less activated but more tolerogenic phenotype. It is showcased that manipulating diets is a potentially efficient and cost-effective approach to prevent and/or ameliorate EAE. This exhibits translational potentials for prevention/intervention of MS and possibly other autoimmune diseases.}, archive = {J_ADVS}, author = {Duan Ni and Jian Tan and Julen Reyes and Alistair M Senior and Caitlin Andrews and Jemma Taitz and Camille Potier-Villette and Claire Wishart and Alanna Spiteri and Laura Piccio and Nicholas Jonathan Cole King and Romain Barrès and David Raubenheimer and Stephen James Simpson and Ralph Nanan and Laurence Macia}, doi = {10.1002/advs.202412236}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2412236}, shortjournal = {Adv. Sci.}, title = {High fat low carbohydrate diet is linked to CNS autoimmunity protection}, volume = {12}, year = {2025}, }
• (2025). Integrating spatial and single-nucleus transcriptomic data to assess the effects of intrauterine hyperglycemia on fetal pancreatic development. ADVS, 12(22), 2411126. (www)

  @article{ , abstract = {Maternal pregestational diabetes mellitus (PGDM) can lead to adverse fetal outcomes, including lasting impacts on pancreatic development. However, the specific impacts of maternal PGDM on cellular functions and intercellular communication within the fetal pancreas remain poorly understood. Here, single-nucleus RNA sequencing and spatial transcriptomics (ST) are employed to investigate cellular responses and spatial changes in the fetal pancreas (E16.5 and E18.5) under maternal PGDM conditions. The findings reveal significant cellular heterogeneity among acinar and beta cells, along with pronounced metabolic stress responses. More importantly, decreased insulin secretion is observed and accompanied by the compensatory increase of Pdx1, Nkx6.2, and Mafa, and substantial alterations in cell-cell communication across multiple cell types. ST analysis further highlights enhanced spatial enrichment in cellular niches exposed to maternal PGDM. These findings provide valuable insights into the molecular mechanisms underlying fetal pancreatic response to maternal PGDM and offer a detailed spatiotemporal perspective on these processes.}, archive = {J_ADVS}, author = {Yu Deng and Shuting Wan and Zan Yuan and Huixia Yang}, doi = {10.1002/advs.202411126}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2411126}, shortjournal = {Adv. Sci.}, title = {Integrating spatial and single-nucleus transcriptomic data to assess the effects of intrauterine hyperglycemia on fetal pancreatic development}, volume = {12}, year = {2025}, }
• (2025). Correlation between fecal microbiota and corticosteroid responsiveness in primary immune thrombocytopenia: An exploratory study. ADVS, 12(22), 2410417. (www)

  @article{ , abstract = {Corticosteroids (CSs) are the initial therapy for immune thrombocytopenia (ITP); however, their efficacy is not adequately predicted. As a novel biomarker, the composition of the gut microbiota is non-invasively tested and altered in patients with ITP. This study aims to develop a predictive model that leverages gut microbiome data to predict the CS response in patients with ITP within the initial four weeks of treatment. Metagenomic sequencing is performed on fecal samples from 212 patients with ITP, 152 of whom underwent CS treatment and follow-up. Predictive models are trained using six machine-learning algorithms, integrating clinical indices and gut microbiome data. The support vector machine (SVM) algorithm-based model has the highest accuracy (AUC = 0.80). This model utilized a comprehensive feature set that combined clinical data (including sex, age, duration, platelet count, and bleeding scales) with selected microbial species (including Bacteroides ovatus , Bacteroides xylanisolvens , and Parabacteroides gordonii ), alpha diversities, KEGG pathways, and microbial modules. This study will provide new ideas for the prediction of clinical CS efficacy, enabling informed decision-making regarding the initiation of CS or personalized treatment in patients with ITP.}, archive = {J_ADVS}, author = {Feng-Qi Liu and Zhuo-Yu An and Li-Juan Cui and Meng-Yu Xiao and Ye-Jun Wu and Wei Li and Bang-Shuo Zhang and Li Yu and Jia Feng and Zhuo-Gang Liu and Ru Feng and Zhong-Xing Jiang and Rui-Bin Huang and Hong-Mei Jing and Jin-Hai Ren and Xiao-Yu Zhu and Yun-Feng Cheng and Yu-Hua Li and He-Bing Zhou and Da Gao and Yi Liu and Fan Yu and Xin Wang and Jian-Lin Qiao and Dai-Hong Hu and Lu-Lu Wang and Meng-Tong Zang and Qi Chen and Qing-Yuan Qu and Jian-Ying Zhou and Meng-Lin Li and Yu-Xiu Chen and Qiu-Sha Huang and Hai-Xia Fu and Yue-Ying Li and Qian-Fei Wang and Xiao-Jun Huang and Xiao-hui Zhang}, doi = {10.1002/advs.202410417}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2410417}, shortjournal = {Adv. Sci.}, title = {Correlation between fecal microbiota and corticosteroid responsiveness in primary immune thrombocytopenia: An exploratory study}, volume = {12}, year = {2025}, }
• (2025). A programmed DNA dynamic assembly-guided molecular amplifier for authentic information decryption. ADVS, 12(22), 2409586. (www)

  @article{ , abstract = {Nucleic acid-based cryptographic approaches are an innovative emerging field for information process. However, the poor reproducibility and interference from bioenvironment of the existing decryption led to different binary translation according to the fixed threshold defined by “Sender”, which seriously affects the authenticity during message communication. Here, a programmed DNA constitutional dynamic network (CDN)-derived adaptive threshold is shown, which is defined by the difference value of the two groups of the output patterns from CDN. Under external stimuli, the threshold is adaptive to the generated dynamic output patterns, which avoids the contrary binary translation from a slight difference on the output under fixed threshold. Importantly, there are two self-calibrating patterns in each output group and the total concentration of constituents from the CDN system are constant, which greatly eliminates the data error. The CDN system is accompanied by computational simulation, which can predict the output patterns of the system at different states. The CDN is used to control the orthogonal and cascaded nanoparticle-based molecular amplifiers to expand the volume of the transmitting message, as well as allow the accurate and specific sensing of DNA. Various state-of-the-art representation is demonstrated by coding and decoding different types of messages.}, archive = {J_ADVS}, author = {Ning Yang and Jie Zhou and Fengying Yuan and Yajuan Liu and Jia Zhang and Ying Zhuo and Yu Ouyang and Yaqin Chai and Pu Zhang and Ruo Yuan}, doi = {10.1002/advs.202409586}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2409586}, shortjournal = {Adv. Sci.}, title = {A programmed DNA dynamic assembly-guided molecular amplifier for authentic information decryption}, volume = {12}, year = {2025}, }
• (2025). Apoptotic vesicles derived from mesenchymal stem cells ameliorate hypersensitivity responses via inducing CD8+ t cells apoptosis with calcium overload and mitochondrial dysfunction. ADVS, 12(22), 2407446. (www)

  @article{ , abstract = {Apoptosis is crucial for maintaining internal homeostasis. Apoptotic vesicles (ApoVs) derived from mesenchymal stem/ stromal cells (MSCs-ApoVs) as natural lipid nanoparticles are attractive candidates for the next generation of immunotherapies. However, the therapeutic potential of MSCs-ApoVs in managing hypersensitivity reactions mediated by CD8 + T cells remains elusive. This research utilized contact hypersensitivity and oral lichenoid reaction models, both of which represent type IV hypersensitivity reactions. ApoVs are shown that derived from stem cells from human exfoliated deciduous teeth (SHED-ApoVs), a subtype of MSCs, directly fused with the plasma membrane of CD8 + T cells, subsequently increasing membrane permeability through L-type voltage-gated Ca 2+ channels. This initiates a cascade of events including calcium overload, mitochondrial dysfunction, and the initiation of apoptosis in these cells. As known, this is the first study to characterize SHED-ApoVs as immune microenvironment modulators, demonstrating their therapeutic potential and mechanism in these reactions. Moreover, analysis of blood samples from patients with oral lichenoid reactions verified the antihypersensitivity property of SHED-ApoVs. This study sheds light on the therapeutic prospects of MSCs-ApoVs and their underlying mechanisms in diseases mediated by CD8 + T cells, contributing novel perspectives for the clinical application of ApoVs and nanovesicle-based cell-free therapies.}, archive = {J_ADVS}, author = {Anqi Liu and Peng Peng and Changze Wei and Fanhui Meng and Xiaoyao Huang and Peisheng Liu and Siyuan Fan and Xinyue Cai and Meiling Wu and Zilin Xuan and Qing Liu and Xinyu Qiu and Zhenlai Zhu and Hao Guo}, doi = {10.1002/advs.202407446}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2407446}, shortjournal = {Adv. Sci.}, title = {Apoptotic vesicles derived from mesenchymal stem cells ameliorate hypersensitivity responses via inducing CD8+ t cells apoptosis with calcium overload and mitochondrial dysfunction}, volume = {12}, year = {2025}, }
• (2025). Hydrophobin-coated echogenic microbubbles for molecular targeting of tumor cells. ADVS, 12(22), 2401526. (www)

  @article{ , abstract = {Cancer is a leading cause of death globally. Early detection of tumors can be an effective way to reduce mortality, however, traditional cancer diagnostic methods are based on the detection of organ dysfunction, which generally occurs at advanced stages of the disease. The first signs of disease initiation appear much earlier as molecular abnormalities yet are challenging to detect. An advanced design of microbubbles is reported that allows molecular targeting for subsequent binding to tumor cells. The microbubbles consist of perfluorocarbon gas encapsulated in a functional and stable shell made of a surface-active protein (hydrophobin HFBI from Trichoderma reesei ) and corresponding fusion protein (HFBI-domZ) onto which antibodies can be easily grafted. The functionality of the bubbles is investigated, among others, using cryogenic transmission electron microscopy (cryo-TEM), confocal microscopy, and in vitro experiments. The results show the potential of the microbubbles as a probe to be used as a targeting contrast agent in ultrasound molecular imaging (MI) for cancer diagnostics.}, archive = {J_ADVS}, author = {Hedar H. Al-Terke and Grégory Beaune and Muhammad Junaid and Jani Seitsonen and Arja Paananen and Pierangelo Metrangolo and Jaakko V. I. Timonen and Jussi Joensuu and Robin H. A. Ras}, doi = {10.1002/advs.202401526}, journal = {Advanced Science}, month = {6}, number = {22}, pages = {2401526}, shortjournal = {Adv. Sci.}, title = {Hydrophobin-coated echogenic microbubbles for molecular targeting of tumor cells}, volume = {12}, year = {2025}, }
• (2025). Flavonifractor plautii or its metabolite desaminotyrosine as prophylactic agents for alleviating myocardial Ischemia/Reperfusion injury (Adv. sci. 21/2025). ADVS, 12(21), 2570166. (www)

  @article{ , archive = {J_ADVS}, author = {Heng Du and Xu Liu and Jianghua Shen and Hailong Yuan and Hao Zhang and Gan Xi and Yujing Li and Yuhan Wang and Jiahe Zhang and Chaofan Yang and Pengfei Xu and Jiawan Wang and Fang Wang and Siqi Liu and Yanan Zhou and Qi Gu and Jingjing Lu and Tuo Wei and Zeyu Gao and Jingyi Zang and Jun Wang and Moshi Song}, doi = {10.1002/advs.202570166}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2570166}, shortjournal = {Adv. Sci.}, title = {Flavonifractor plautii or its metabolite desaminotyrosine as prophylactic agents for alleviating myocardial Ischemia/Reperfusion injury (Adv. sci. 21/2025)}, volume = {12}, year = {2025}, }
• (2025). Gut microbiota colonization in early life influences susceptibility to adulthood hepatic lipid accumulation in high-fat-diet-fed mice (Adv. sci. 21/2025). ADVS, 12(21), 2570165. (www)

  @article{ , archive = {J_ADVS}, author = {Yan-Yan Zhu and Xin Dong and Hao Zhou and Ze-Yan Li and Bo Wang and Ya-Ping Song and Zhi-Bing Liu and Xue Lu and Yi-Hao Zhang and Yichao Huang and Hua Wang and De-Xiang Xu}, doi = {10.1002/advs.202570165}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2570165}, shortjournal = {Adv. Sci.}, title = {Gut microbiota colonization in early life influences susceptibility to adulthood hepatic lipid accumulation in high-fat-diet-fed mice (Adv. sci. 21/2025)}, volume = {12}, year = {2025}, }
• (2025). Identification of tumor-specific surface proteins enables quantification of extracellular vesicle subtypes for early detection of pancreatic ductal adenocarcinoma (Adv. sci. 21/2025). ADVS, 12(21), 2570164. (www)

  @article{ , archive = {J_ADVS}, author = {Chen Zhao and Zhili Wang and Hyoyong Kim and Hui Kong and Junseok Lee and Jacqueline Ziqian Yang and Anmin Wang and Ryan Y. Zhang and Yong Ju and Jina Kim and Bing Feng and Dejun Liu and Yating Zhang and Zhenfang Wang and Yandong Zhang and Shujing Guo and Dekang Gao and James S. Tomlinson and Renjun Pei and Jipeng Wan and Stephen J. Pandol and Myung-Shin Sim and Sungyong You and Ding Ma and Shaohua Lu and Na Sun and Hsian-Rong Tseng and Yazhen Zhu}, doi = {10.1002/advs.202570164}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2570164}, shortjournal = {Adv. Sci.}, title = {Identification of tumor-specific surface proteins enables quantification of extracellular vesicle subtypes for early detection of pancreatic ductal adenocarcinoma (Adv. sci. 21/2025)}, volume = {12}, year = {2025}, }
• (2025). Histone deacetylase 6 (HDAC6) in ciliopathies: Emerging insights and therapeutic implications (Adv. sci. 21/2025). ADVS, 12(21), 2570163. (www)

  @article{ , archive = {J_ADVS}, author = {Zhiyi Wang and Xiaofan Zhu and Zhenzhou Huang and Kaidi Ren and Jie Ran and Yang Yang}, doi = {10.1002/advs.202570163}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2570163}, shortjournal = {Adv. Sci.}, title = {Histone deacetylase 6 (HDAC6) in ciliopathies: Emerging insights and therapeutic implications (Adv. sci. 21/2025)}, volume = {12}, year = {2025}, }
• (2025). Dissolution of spent lithium-ion battery cathode materials: Overlooked significance of aluminum impurities (Adv. sci. 21/2025). ADVS, 12(21), 2570161. (www)

  @article{ , archive = {J_ADVS}, author = {Kang Liu and Yuying Zhang and Mengmeng Wang and Xiaohong Zhu and Roya Maboudian and Daniel C.W. Tsang}, doi = {10.1002/advs.202570161}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2570161}, shortjournal = {Adv. Sci.}, title = {Dissolution of spent lithium-ion battery cathode materials: Overlooked significance of aluminum impurities (Adv. sci. 21/2025)}, volume = {12}, year = {2025}, }
• (2025). Two steps li ion storage mechanism in Ruddlesden–Popper Li2La2Ti3O10 (Adv. sci. 21/2025). ADVS, 12(21), 2570160. (www)

  @article{ , archive = {J_ADVS}, author = {Mi Jang and Sunhyun Hwang and Ji Su Chae and Gun Jang and Ho Seok Park and Yunki Lee and JungHyun Choi and Won-Sub Yoon and Kwang Chul Roh}, doi = {10.1002/advs.202570160}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2570160}, shortjournal = {Adv. Sci.}, title = {Two steps li ion storage mechanism in Ruddlesden–Popper Li2La2Ti3O10 (Adv. sci. 21/2025)}, volume = {12}, year = {2025}, }
• (2025). High-fidelity computational microscopy via feature-domain phase retrieval (Adv. sci. 21/2025). ADVS, 12(21), 2570159. (www)

  @article{ , archive = {J_ADVS}, author = {Shuhe Zhang and An Pan and Hongbo Sun and Yidong Tan and Liangcai Cao}, doi = {10.1002/advs.202570159}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2570159}, shortjournal = {Adv. Sci.}, title = {High-fidelity computational microscopy via feature-domain phase retrieval (Adv. sci. 21/2025)}, volume = {12}, year = {2025}, }
• (2025). High-performance synapse arrays for neuromorphic computing via floating gate-engineered IGZO synaptic transistors (Adv. sci. 21/2025). ADVS, 12(21), 2570158. (www)

  @article{ , archive = {J_ADVS}, author = {Junhyeong Park and Yumin Yun and Sunyeol Bae and Yuseong Jang and Seungyoon Shin and Soo-Yeon Lee}, doi = {10.1002/advs.202570158}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2570158}, shortjournal = {Adv. Sci.}, title = {High-performance synapse arrays for neuromorphic computing via floating gate-engineered IGZO synaptic transistors (Adv. sci. 21/2025)}, volume = {12}, year = {2025}, }
• (2025). Precision-guided stealth missiles in biomedicine: Biological carrier-mediated nanomedicine hitchhiking strategy. ADVS, 12(21), 2504672. (www)

  @article{ , abstract = {Nanodrug delivery systems (NDDS) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to several advantages, including functionalization capability, high drug-loading capacity, drug stability protection, and the enhanced permeability and retention (EPR) effect. However, their clinical translation still faces multiple challenges, including rapid clearance by the reticuloendothelial system (RES), poor targeting specificity, and insufficient efficiency in crossing biological barriers. To address these limitations, researchers have developed the biological carrier-mediated nanomedicine hitchhiking strategy (BCM-NHS), which leverages circulating cells, proteins, or bacteria as natural “mobile carriers” to enhance drug delivery. This approach enables nanocarriers to inherit the intrinsic biological properties, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, biodegradability, and naturally optimized biological interfaces. Here, a systematic overview of the BCM-NHS is provided. First, the review delves into the methods of nanoparticles (NPs) binding and immobilization, encompassing both the surface-attachment-mediated “backpack” strategy and the encapsulation-based “Trojan horse” strategy. Second, the classification of biological carriers, including both cell-based and non-cell-based carriers, is elucidated. Third, the physical properties and release mechanisms of these nanomaterials are thoroughly described. Finally, the latest applications of BCM-NHS in therapeutic and diagnostic contexts across various disease models including tumor, ischemic stroke, and pneumonia are highlighted.}, archive = {J_ADVS}, author = {Yuyan Zhou and Xinyue Wang and Deyu Zhang and Hanxiao Cui and Xiaorong Tian and Wei Du and Zhenghui Yang and Dongling Wan and Zhiwei Qiu and Chao Liu and Zhicheng Yang and Lizhihong Zhang and Qiusheng Yang and Xuefeng Xu and Wenhao Li and Dong Wang and Haojie Huang and Wencheng Wu}, doi = {10.1002/advs.202504672}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2504672}, shortjournal = {Adv. Sci.}, title = {Precision-guided stealth missiles in biomedicine: Biological carrier-mediated nanomedicine hitchhiking strategy}, volume = {12}, year = {2025}, }
• (2025). Correction to “Activated drp1 initiates the formation of endoplasmic reticulum-mitochondrial contacts via shrm4-mediated actin bundling”. ADVS, 12(21), 2504531. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202504531}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2504531}, shortjournal = {Adv. Sci.}, title = {Correction to “Activated drp1 initiates the formation of endoplasmic reticulum-mitochondrial contacts via shrm4-mediated actin bundling”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Non-invasive photoacoustic cerebrovascular monitoring of early-stage ischemic strokes in vivo”. ADVS, 12(21), 2502992. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202502992}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2502992}, shortjournal = {Adv. Sci.}, title = {Correction to “Non-invasive photoacoustic cerebrovascular monitoring of early-stage ischemic strokes in vivo”}, volume = {12}, year = {2025}, }
• (2025). Therapeutic potential of lipid nanoparticle-encapsulated CD19-targeting mRNAs in lupus and rheumatoid arthritis. ADVS, 12(21), 2501628. (www)

  @article{ , abstract = {The hyperactivation of autoreactive B cells and plasma cells leads to the development of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), therefore, targeting the abnormal B cells and plasma cells might hold promise for the treatment of these refractory and relapsing diseases. This study developed l ipid n ano p article-encapsulated mRN A-encoding a nti b odies (mRNab-LNPs) targeting CD19, and evaluated their therapeutic efficacy in lupus and RA mice. mRNab-LNPs enabled robust production of anti-CD19 antibodies in multiple cell lines in vitro. Interestingly, intramuscular injection of mRNab-LNPs resulted in high and sustained production of anti-CD19 antibodies in mice. In particular, the numbers of CD19+ circulating B cells and tissue-resident plasma cells are significantly reduced by mRNab-LNPs in mice. As a result, mRNab-LNPs significantly reduced the histopathological changes and tissue injuries in both lupus and RA mice. Collectively, these findings demonstrate the therapeutic and translational potential of mRNab-LNPs in the treatment of SLE and RA.}, archive = {J_ADVS}, author = {Chipeng Guo and Yingsen Tang and Ling Zeng and Xiaomei You and Siweier Luo and Yufei Du and Le Wang and Liangchun Wang and Jianchuan Wang and Jinjin Chen and Yiming Zhou}, doi = {10.1002/advs.202501628}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2501628}, shortjournal = {Adv. Sci.}, title = {Therapeutic potential of lipid nanoparticle-encapsulated CD19-targeting mRNAs in lupus and rheumatoid arthritis}, volume = {12}, year = {2025}, }
• (2025). Recent advances in xenes based FET for biosensing applications. ADVS, 12(21), 2500752. (www)

  @article{ , abstract = {In recent years, monoelemental 2D materials (Xenes) such as graphene, graphdiyne, silicene, phosphorene, and tellurene, have gained significant traction in biosensing applications. Owing to their ultra-thin layered structure, exceptionally high specific surface area, unique surface electronic properties, excellent mechanical strength, flexibility, and other distinctive features, Xenes are recognized for their potential as materials with low detection limits, high speed, and exceptional flexibility in biosensing applications. In this review, the unique properties of Xenes, their synthesis, and recent theoretical and experimental advances in applications related to biosensing, including DNA/RNA biosensors, protein biosensors, small molecule biosensors, cell, and ion biosensors are comprehensively summarized. Finally, the challenges and prospects of this emerging field are discussed.}, archive = {J_ADVS}, author = {Huide Wang and Chen Wang and Yule Zhang and Ziqian Wang and Yihan Zhu and Yun Wang and Xiangqian Hong and Han Zhang and Ning Fan and Meng Qiu}, doi = {10.1002/advs.202500752}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2500752}, shortjournal = {Adv. Sci.}, title = {Recent advances in xenes based FET for biosensing applications}, volume = {12}, year = {2025}, }
• (2025). High-performance synapse arrays for neuromorphic computing via floating gate-engineered IGZO synaptic transistors. ADVS, 12(21), 2500568. (www)

  @article{ , abstract = {Neuromorphic computing emulating the human brain offers a promising alternative to the Von Neumann architecture. Developing artificial synapses is essential for implementing hardware neuromorphic systems. Indium-gallium-zinc oxide (IGZO)-based synaptic transistors using charge trapping have advantages, such as low-temperature process and complementary metal-oxide-semiconductor compatibility. However, these devices face challenges of low charge de-trapping efficiency and insufficient retention. Here, IGZO synaptic transistors are introduced utilizing an indium-tin oxide (ITO) floating gate (FG) to overcome these limitations. The ITO FG's higher conductivity and alleviated chemical interactions with the Al 2 O 3 tunneling layer (TL) deposited by atomic layer deposition result in enhanced electrical performance with a smooth FG/TL interface. An 8 × 8 synapse array achieves 100% yield and successful programming without interference using a half-pulse scheme. Spiking neural network simulations on MNIST and Fashion-MNIST datasets demonstrate high accuracies of 98.31% and 87.76%, respectively, despite considering device variations and retention. These findings highlight the potential of IGZO synaptic transistors for neuromorphic computing applications.}, archive = {J_ADVS}, author = {Junhyeong Park and Yumin Yun and Sunyeol Bae and Yuseong Jang and Seungyoon Shin and Soo-Yeon Lee}, doi = {10.1002/advs.202500568}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2500568}, shortjournal = {Adv. Sci.}, title = {High-performance synapse arrays for neuromorphic computing via floating gate-engineered IGZO synaptic transistors}, volume = {12}, year = {2025}, }
• (2025). Flavonifractor plautii or its metabolite desaminotyrosine as prophylactic agents for alleviating myocardial Ischemia/Reperfusion injury. ADVS, 12(21), 2417827. (www)

  @article{ , abstract = {Myocardial ischemia/reperfusion (I/R) injury is a major contributor to myocardial damage, leading to adverse cardiac remodeling and dysfunction. Recent studies have highlighted the potential of gut microbiota-derived metabolites in modulating cardiac outcomes. Here, the cardioprotective effects of a commensal bacterium Flavonifractor plautii ( F. plautii ) and its metabolite desaminotyrosine (DAT) against myocardial I/R injury are investigated. We showed that prophylactic gavage of F. plautii attenuates myocardial I/R injury as evidenced by improved cardiac function and reduced cardiac injury. We also found that its metabolite DAT recapitulates these cardioprotective effects against myocardial I/R injury. Transcriptomic analysis has revealed that DAT preserves cardiac tissue and attenuates immune responses against myocardial I/R injury. Mechanistically, DAT promotes cardiomyocyte survival through the modulation of the nicotinamide adenine dinucleotide phosphate (NADP + /NADPH) ratio. Further, DAT suppressed macrophage proinflammatory activities and cardiac inflammation via the reduction in interleukin-6 (IL-6) production. Taken together, our findings indicate that F. plautii and its metabolite DAT exert pleiotropic cardioprotective effects against myocardial I/R injury, suggesting them as potential prophylactic therapeutic options for alleviating myocardial I/R injury.}, archive = {J_ADVS}, author = {Heng Du and Xu Liu and Jianghua Shen and Hailong Yuan and Hao Zhang and Gan Xi and Yujing Li and Yuhan Wang and Jiahe Zhang and Chaofan Yang and Pengfei Xu and Jiawan Wang and Fang Wang and Siqi Liu and Yanan Zhou and Qi Gu and Jingjing Lu and Tuo Wei and Zeyu Gao and Jingyi Zang and Jun Wang and Moshi Song}, doi = {10.1002/advs.202417827}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2417827}, shortjournal = {Adv. Sci.}, title = {Flavonifractor plautii or its metabolite desaminotyrosine as prophylactic agents for alleviating myocardial Ischemia/Reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Dissolution of spent lithium-ion battery cathode materials: Overlooked significance of aluminum impurities. ADVS, 12(21), 2417737. (www)

  @article{ , abstract = {Impurities are pivotal in determining the quality of the critical metal products derived from spent lithium-ion batteries (LIBs), but there is a lack of understanding of their potential impacts. The mechanisms by which Aluminium (Al) impurities permeate the active crystals of spent ternary nickel─cobalt─manganese oxide (NCM) cathode materials and interact with critical metal sites are elucidated. During frictional contact, the substitution of transition metals by Al impurities disrupts the bonding between critical metals and oxygen, leading to the formation of more stable Al─O covalent bonds. Al can preferentially substitute for Co, altering the local coordination and electronic structure of transition metals. Owing to the strong interaction of Al─O, the Fermi level shifts downward, thus increasing the stabilization of lattice oxygen in the NCM cathode materials and consequently delaying the dissolution of NCM cathode materials. In different extraction environments, the invasion of Al retards the release of lattice oxygen and inhibits the dissolution of NCM in formic acid but enhances those in ammonia solution and shows mixed results in deep eutectic solvents. These crucial findings will help to elucidate the mechanisms of Al impurities in the recycling industry chain of retired LIBs, thereby enhancing the recovery of high-quality critical metal products.}, archive = {J_ADVS}, author = {Kang Liu and Yuying Zhang and Mengmeng Wang and Xiaohong Zhu and Roya Maboudian and Daniel C.W. Tsang}, doi = {10.1002/advs.202417737}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2417737}, shortjournal = {Adv. Sci.}, title = {Dissolution of spent lithium-ion battery cathode materials: Overlooked significance of aluminum impurities}, volume = {12}, year = {2025}, }
• (2025). Pyridine-fused bis(azacorrole)s: Easily accessible NIR III absorbing cation radicals and biradicaloids of antiaromatic ground state. ADVS, 12(21), 2416223. (www)

  @article{ , abstract = {A family of pyridine-fused bis(porphyrinoids) is obtained, including constitutionally isomeric bis(azacorrole)s, azacorrole-oxacorrole, as well as azacorrole-norcorrole heterodimers by two distinct synthetic approaches. Spectroscopic characteristics, corroborated by Density Functional Theory (DFT) calculations, indicate aromaticity of the bis(azacorrole) as well as azacorrole-oxacorrole products, while for the azacorrole-norcorrole heterodimers, the presence of both dia- and paratropic currents is detected. Electrochemical analyses indicate facile chemical access to cation radicals and dicationic species that have been characterized by electronic and electron spin resonance spectroscopy as well as by DFT calculations. Monocations give rise to the relatively strong absorption bands in the near infra red (NIR) region between 2400 and 3200 nm, while dications are characterized by a series of absorptions between 1000 and 2200 nm. Electron spin resonance (ESR) experiments indicate the presence of singlet-triplet spin equilibria for the dications. For the dication of bis(azacorrole) of the most planar structure, the singlet ground state is established, and low temperature nuclear magnetic resonance (NMR) as well as gauge-independent atomic orbital NMR calculations indicate its antiaromatic character.}, archive = {J_ADVS}, author = {Sha Li and Shaowei Zhang and Xiaofang Li and Oskar Smaga and Kinga Szydełko and Miłosz Pawlicki and Piotr J. Chmielewski}, doi = {10.1002/advs.202416223}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2416223}, shortjournal = {Adv. Sci.}, title = {Pyridine-fused bis(azacorrole)s: Easily accessible NIR III absorbing cation radicals and biradicaloids of antiaromatic ground state}, volume = {12}, year = {2025}, }
• (2025). Discovery, herbicidal activity and biosynthesis of a novel natural tetramic acid from alternaria species. ADVS, 12(21), 2416188. (www)

  @article{ , abstract = {The tetramic acid moiety is a pivotal structural unit in numerous natural products. As an analogue of the simplest tetramic acid compound tenuazonic acid (TeA), sec-pentyl-TeA (S-TeA) exhibits double herbicidal activity of TeA. Here, this work identifies S-TeA as a novel natural product synthesized by Alternaria alternata and three other filamentous fungi. Chiral analysis confirm the absolute configuration of natural S-TeA as (5 S , 6 S ). Configuration-bioactivity studies reveal that natural (5 S , 6 S )-S-TeA is the eutomer and possesses the highest herbicidal activity among all tested diastereomers. Biosynthetic analyses demonstrate that threonine is the precursor to S-TeA, beginning with the production of 2-amino-3-methylhexanoic acid (AMHA) via eight enzymes from the branched-chain amino acid (BCAA) biosynthetic pathway, including threonine deaminase, 2-isopropylmalate synthase (IPMS), 3-isopropylmalate dehydratase (IPMDH), isopropylmalate dehydrogenase (ISMD), acetolactate synthase, ketol-acid reductoisomerase, dihydroxy acid dehydratase, and BCAA aminotransferase. Subsequently, AMHA undergoes acetylation and cyclization by non-ribosomal peptide synthetases to form S-TeA. Distinct differences in the biosynthetic pathways of S-TeA and TeA are identified. In vitro studies confirm the critical roles of three unique enzymes IPMS, IPMDH, and ISMD in S-TeA biosynthesis, which are absent in TeA biosynthesis. These findings provide a solid basis for developing S-TeA as a natural product herbicide.}, archive = {J_ADVS}, author = {He Wang and Yanjing Guo and Qing Liu and Jing Zhang and Qianlong Zhang and Mingying Yang and Qizhen Chen and Sheng Qiang and Bernal E. Valverde and Shiguo Chen}, doi = {10.1002/advs.202416188}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2416188}, shortjournal = {Adv. Sci.}, title = {Discovery, herbicidal activity and biosynthesis of a novel natural tetramic acid from alternaria species}, volume = {12}, year = {2025}, }
• (2025). Minimizing energy demand in the conversion of levulinic acid to γ‑Valerolactone via photothermal catalysis using raney ni. ADVS, 12(21), 2416153. (www)

  @article{ , abstract = {The valorization of lignocellulosic wastes emerges as a prime strategy to mitigate the global carbon footprint. Among the multiple biomass derivatives, γ-valerolactone is particularly attractive as precursor of high-value chemicals, biofuel, green solvent or perfumery. γ-Valerolactone can be synthesized through a hydrogenation reaction from levulinic acid, obtained from cellulose. However, the high energy requirements of this synthetic pathway have hindered its industrial viability. To drastically reduce the reaction energy requirements, here a novel synthetic strategy, based on solvothermal-photothermal processes using cost-effective Raney-Ni as photothermal catalyst, is proposed. First, the use of hydrogen gas is avoided by selecting isopropanol as a safer and greener H-source. Second, a photothermocatalytic process is used to minimize the reaction temperature and time with respect to conventional reactions. This approach exploits the broadband optical absorption of the Raney®-Ni, due to its highly damped plasmonic behavior, to achieve fast and efficient catalyst heating inside the reactor. The photothermal reaction required less than 2 h and just 132 °C to reach over 95% conversion, thereby drastically reducing the reaction time and energy consumption compared to conventional reactions. Importantly, these conditions granted high catalyst reusability. This solvothermal-photothermal approach could offer a sustainable alternative for the industrial production of γ-valerolactone.}, archive = {J_ADVS}, author = {Roger Bujaldón and Arnau Fons and Jaume Garcia-Amorós and Cristina Vaca and Josep Nogués and Maria José Esplandiu and Elvira Gómez and Borja Sepúlveda and Albert Serrà}, doi = {10.1002/advs.202416153}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2416153}, shortjournal = {Adv. Sci.}, title = {Minimizing energy demand in the conversion of levulinic acid to γ‑Valerolactone via photothermal catalysis using raney ni}, volume = {12}, year = {2025}, }
• (2025). Glycolysis-derived lactate induces ACSL4 expression and lactylation to activate ferroptosis during intervertebral disc degeneration. ADVS, 12(21), 2416149. (www)

  @article{ , abstract = {The abnormal activation of the inflammatory microenvironment is frequently accompanied by metabolic changes that affect the development of various diseases. However, the relationship between metabolic reprogramming and intervertebral disc degeneration (IVDD) remains unclear. This study aims to reveal the metabolic changes in nucleus pulposus (NPCs) during IVDD and investigate the mechanism of glycolysis-derived lactate on NPCs. Single-cell RNA sequencing reveals that during IVDD, NPCs are characterized by excessively elevated glycolysis, and the resultant lactate causes the dysfunction of NPCs via ferroptosis activation. Mechanistically, lactate results in the transcription of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) via promoting Histon H3K18 lactylation. Interestingly, lactate can also increase the lactylation of ACSL4 at K412 site. In addition, lactate-induced decreased expression of Sirtuin-3 (SIRT3), and further cause the elevation of ACSL4 lactylation. Finally, animal experiments demonstrate that inhibiting glycolysis through gene silencing with adenoviral-associated viruses 9 (AAV9)-si- Ldha or chemical treatment using 2-deoxy- D -glucose can suppress lactate production and lactylation, thereby ameliorating ferroptosis and NPC dysfunction. The findings of this study indicate that lactate plays a crucial role in IVDD by activating ferroptosis and that interventions aimed at lactate production can offer a potential therapeutical option for patients with IVDD.}, archive = {J_ADVS}, author = {Kaiqiang Sun and Yangyang Shi and Chen Yan and Shunmin Wang and Linhui Han and Fudong Li and Ximing Xu and Yuan Wang and Jingchuan Sun and Zijian Kang and Jiangang Shi}, doi = {10.1002/advs.202416149}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2416149}, shortjournal = {Adv. Sci.}, title = {Glycolysis-derived lactate induces ACSL4 expression and lactylation to activate ferroptosis during intervertebral disc degeneration}, volume = {12}, year = {2025}, }
• (2025). Viridicatol from the deep-sea-derived fungus alleviates bone loss by targeting the Wnt/SHN3 pathway. ADVS, 12(21), 2416140. (www)

  @article{ , abstract = {As an enticing bone anabolic target, short-term inhibition of Schnurri-3 (SHN3) resulted in high-bone mass due to augmented osteoblast activity. However, no studies are conducted to identify natural products targeting SHN3 inhibition. Herein, a screening strategy for the discovery of marine compounds that facilitate osteoblast differentiation by targeting SHN3 silencing is presented. One leading quinolinone alkaloid, viridicatol (VDC), isolated from deep-sea-derived fungus, vigorously promotes osteogenic differentiation via the Wnt/SHN3 signaling pathway in osteoblasts, thereby preventing osteoporosis while enhancing bone-fracture healing in a mouse model. Subsequently, the SDSSD (Ser, Asp, Ser, Ser, Asp) is further employed to engineer bone-targeting nanovesicles (BT-NVs) for the optimal delivery of VDC to osteoblasts, which mitigates the bone loss observed in a severe osteogenesis imperfecta model. Hence, these results initially uncover a promising marine natural product, VDC, targeting the Wnt/SHN3 pathway for the treatment of bone loss and highlighting its translational potential in clinical applications.}, archive = {J_ADVS}, author = {Chun-Lan Xie and Shang-Hui Ye and Yu-Ting Yue and Bao-Hong Shi and Jing-Ping Xu and Lian-Jie Li and Zheng-Biao Zou and Matthew B. Greenblatt and Na Li and Xian-Wen Yang and Ren Xu}, doi = {10.1002/advs.202416140}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2416140}, shortjournal = {Adv. Sci.}, title = {Viridicatol from the deep-sea-derived fungus alleviates bone loss by targeting the Wnt/SHN3 pathway}, volume = {12}, year = {2025}, }
• (2025). Nanoneedle-based electroporation for efficient manufacturing of human primary chimeric antigen receptor regulatory T-cells. ADVS, 12(21), 2416066. (www)

  @article{ , abstract = {Regulatory T cells (Tregs) play a crucial role in moderating immune responses offering promising therapeutic options for autoimmune diseases and allograft rejection. Genetically engineering Tregs with chimeric antigen receptors (CARs) enhances their targeting specificity and efficacy. With non-viral transfection methods suffering from low efficiency and reduced cell viability, viral transduction is currently the only viable approach for GMP-compliant CAR-Treg production. However, viral transduction raises concerns over immunogenicity, insertional mutagenesis risk, and high costs, which limit clinical scalability. This study introduces a scalable nanoneedle electroporation (nN-EP) platform for GMP-compatible transfection of HLA-A2-specific CAR plasmids into primary human Tregs. The nN-EP system achieves 43% transfection efficiency, outperforming viral transduction at multiplicity of infection 1 by twofold. Importantly, nN-EP preserves Treg viability, phenotype and proliferative capacity. HLA-A2-specific CAR-Tregs generated using nN-EP show specific activation and superior suppressive function compared to polyclonal or virally transduced Tregs in the presence of HLA-A2 expressing antigen presenting cells. These findings underscore the potential of nN-EP as a GMP-suitable method for CAR-Treg production, enabling broader clinical application in immune therapies.}, archive = {J_ADVS}, author = {Ningjia Sun and Cong Wang and William Edwards and Yikai Wang and Xiangrong L. Lu and Chenlei Gu and Samuel McLennan and Panicos Shangaris and Peng Qi and Daniela Mastronicola and Cristiano Scottà and Giovanna Lombardi and Ciro Chiappini}, doi = {10.1002/advs.202416066}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2416066}, shortjournal = {Adv. Sci.}, title = {Nanoneedle-based electroporation for efficient manufacturing of human primary chimeric antigen receptor regulatory T-cells}, volume = {12}, year = {2025}, }
• (2025). Time-resolved dynamics of laser ablation in liquid with gas-evolving additives: Toward molding the atomic structure of nonequilibrium nanoalloys. ADVS, 12(21), 2416035. (www)

  @article{ , abstract = {Laser ablation in liquid (LAL) is a reference technique for the synthesis of multicomponent non-equilibrium nanomaterials which have potentially disruptive properties in photonics, nanomedicine, and catalysis. Yet, ablation dynamics is poorly understood regarding the multielement matter and, therefore, the remarkable potential of LAL for controlling the local atomic structure of metastable nanophases remains largely unexploited. Here, the dynamics of LAL are investigated with non-equilibrium gold-iron nanoalloys generated in the presence of gas-evolving additives, which drive the formation of different nanostructures. With analytical electron microscopy, the structure in the different conditions is properly identified through complete segregation into oxide-metal heterostructures, precipitation of nanoclusters within the nanoalloys, or ordered solid solutions. To elucidate the unforeseen effects of the solutes on the atomic structure of nanoalloys, the early and full dynamics of LAL is investigated with time-resolved experiments, leading to the pivotal evidence that alloying of metastable compounds with different chemical reactivity is favored by decreasing the pressure of the shockwave front. The resulting picture indicates LAL with gas-evolving additives as a strategy for molding the atomic structure of non-equilibrium nanoalloys, opening the way to the development of a library of advanced nanomaterials otherwise inaccessible.}, archive = {J_ADVS}, author = {Vito Coviello and Catherine Reffatto and Mehdi W. Fawaz and Benoit Mahler and Arnaud Sollier and Bratislav Lukic and Alexander Rack and David Amans and Vincenzo Amendola}, doi = {10.1002/advs.202416035}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2416035}, shortjournal = {Adv. Sci.}, title = {Time-resolved dynamics of laser ablation in liquid with gas-evolving additives: Toward molding the atomic structure of nonequilibrium nanoalloys}, volume = {12}, year = {2025}, }
• (2025). Constructing ion-bridging structure with controlled cracks in plasticized PVC with graphene for highly sensitive strain sensor with a wide strain range. ADVS, 12(21), 2415998. (www)

  @article{ , abstract = {The gauge factor (GF) is a critical parameter for strain sensors, but it faces limitations in achieving high GF values across a wide strain range. This work proposes a novel approach to enhance resistance changes within strains through synergistically combining controlled-crack sizing and an ion-bridging structure. This ion-conductive bridge forms at the interface between graphene and polyvinyl chloride (PVC) gel. Precise management of the crack initiation and propagation on graphene is achieved by controlling adhesion force between graphene and PVC gel. The resulting PVC gel/graphene-based strain sensor featuring this synergistic design exhibits exceptional sensitivity. It achieves GFs of 635 (ε < 40%), 1.5 × 10 6 (40% < ε < 80%), and 7.8 × 10 5 (80% < ε < 100%) over a 100% stretching range. This innovative ion-bridging construction enables precise control over bridge connectivity at the interface, mitigating graphene's inherent stretchability limitations and enhancing the GF of PVC gel, thereby enhancing strain sensor performance. The sensor detects bending motions and monitors angles within higher strain ranges, making it suitable for wearable applications in human motion tracking. Furthermore, a PVC-based posture correction system distinguishes various motions, including shoulder band stretching, armband stretching, and even full squats, showcasing its practicality and versatility.}, archive = {J_ADVS}, author = {Hyosik Park and Mingyu Kim and Gerald Selasie Gbadam and Cheoljae Lee and Hyeonseo Joo and Sujeong Gwak and Bo-Yeon Lee and Kyeong Nam Kim and Ju-Hyuck Lee}, doi = {10.1002/advs.202415998}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415998}, shortjournal = {Adv. Sci.}, title = {Constructing ion-bridging structure with controlled cracks in plasticized PVC with graphene for highly sensitive strain sensor with a wide strain range}, volume = {12}, year = {2025}, }
• (2025). Targeting PTBP3-mediated alternative splicing of COX11 induces cuproptosis for inhibiting gastric cancer peritoneal metastasis. ADVS, 12(21), 2415983. (www)

  @article{ , abstract = {Numerous aberrant splicing events are implicated in tumor progression, yet comprehensive reports on splicing factors and events associated with peritoneal metastasis in gastric cancer (GCPM) are lacking. In this study, PTBP3 is found to be significantly overexpressed in peritoneal metastatic tissues of gastric cancer compared to primary tumor tissues, and higher PTBP3 expression correlates with poorer prognosis. Using gastric cancer cells and patient-derived organoids (PDO), the role of PTBP3 in promoting tumor invasion and proliferation is investigated. Mechanistically, through full-length transcriptome sequencing, PTBP3 mediates exon 4 skipping in its target gene COX11, leading to shorter transcripts that impair COX11 protein function, reducing mitochondrial copper content and enabling tumor cells to evade cuproptosis. Antisense oligonucleotide (ASO) drugs targeting the short COX11 transcripts effectively degrade mRNA, disrupting copper homeostasis. In PDO-based xenograft models, exogenous copper ionophores combined with ASO drugs induce excessive copper accumulation in mitochondria, triggering proteotoxic stress and cuproptosis. Overall, PTBP3-mediated exon 4 skipping in COX11 pre-mRNA is critical for tumor cell survival and progression in GCPM, offering potential therapeutic strategies targeting copper metabolism.}, archive = {J_ADVS}, author = {Yajing Zhou and Chao Dong and Xiaochun Shen and Pengbo Wang and Tao Chen and Weikang Li and Xiaotong Sun and Peiyuan Li and Chengxiang Xu and Kaipeng Duan and Dongbao Li and Jin Zhou}, doi = {10.1002/advs.202415983}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415983}, shortjournal = {Adv. Sci.}, title = {Targeting PTBP3-mediated alternative splicing of COX11 induces cuproptosis for inhibiting gastric cancer peritoneal metastasis}, volume = {12}, year = {2025}, }
• (2025). Chronic, battery-free, fully implantable multimodal spinal cord stimulator for pain modulation in small animal models. ADVS, 12(21), 2415963. (www)

  @article{ , abstract = {Spinal cord stimulation (SCS) for chronic pain management is an invasive therapy involving surgical implantation of electrodes into spinal epidural space. While the clinical value and mechanistic action of the therapy is debated considerably in recent years, preclinical chronic studies employing rodent models can provide invaluable insights regarding the balance between efficacy and complications as well as mechanistic understanding of SCS therapy. However, current rodent compatible devices require tethered power delivery or bulky batteries, severely limiting the ability to probe long-term efficacy of SCS therapy. This work introduces a tether-free, small-footprint, fully implantable, battery-free SCS device compatible with rodent models, capable of delivering electrical stimulation to the spinal cord at a wide range of frequency, amplitude, and period via wireless communication adjustable on-demand without direct interaction with the animal. The presented device features capabilities of clinical SCS devices, with materials and processes amendable to scalable fabrication at a cost suitable for one-time use enabling high N studies. In this proof of concept, the implantable device serves to assess therapeutic efficacy of various clinically relevant SCS paradigms in alleviating neuropathic pain. This technology offers chronic stability and the potential to serve as the foundation for future research into the development of SCS therapeutic systems.}, archive = {J_ADVS}, author = {Allie J. Widman and Taron Bashar and Alex Burton and David Marshall Clausen and Prashant Gupta and Drew K. Wolf and Jakayla Folarin-Hines and Maria Payne and John A Rogers and Kathleen W. Meacham and Robert W. Gereau and Philipp Gutruf}, doi = {10.1002/advs.202415963}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415963}, shortjournal = {Adv. Sci.}, title = {Chronic, battery-free, fully implantable multimodal spinal cord stimulator for pain modulation in small animal models}, volume = {12}, year = {2025}, }
• (2025). Liquid crystalline self-assembly with accelerated kinetics and higher structural orderliness in centrifugal acceleration fields beyond 7251 times gravity of earth. ADVS, 12(21), 2415955. (www)

  @article{ , abstract = {Gravity of the Earth ( g ) drives the macroscopic differentiation of multiple phases with different volumetric mass densities in many chemical and physical processes. Herein, liquid crystalline phase separation of colloidal dispersions of rod-shaped cellulose nanoparticles in centrifugal acceleration fields up to 71 061 meters per second squared (7251 g ) is studied. Through non-ionic in situ free-radical polymerization initiated by time-controllable oxidation–reduction reactions between tert-butyl hydroperoxide (oxidants) and thiourea (thiocarbamide, reductants) at room temperature (298 kelvins), ordered soft microstructures formed by entropy-driven self-assembly are immobilized within crosslinked polyacrylamide matrixes at various evolution stages (e.g., after 10, 30, or 60 min) in centrifuge tubes. Based on cross-sectional polarized optical and scanning electron microscopy, strong centrifugal acceleration fields accelerated the movement velocity of discrete liquid crystalline tactoidal microphases, the coalescence of tactoids into continuous chiral nematic structures, as well as the translational and rotational relaxation rates of mesogenic nanorods at kinetically arrested states in high-viscosity concentrated colloidal liquid crystals, leading to the elimination of topological defects and improvements in structural orderliness. Since acceleration is indistinguishable from a homogeneous gravitational field according to Einstein's principle of equivalence in general relativity, these results might help to predict self-assembling behaviors near compact astrophysical objects such as neutron stars.}, archive = {J_ADVS}, author = {Lingyan Xu and Hongbo Zhao and Pei-Xi Wang}, doi = {10.1002/advs.202415955}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415955}, shortjournal = {Adv. Sci.}, title = {Liquid crystalline self-assembly with accelerated kinetics and higher structural orderliness in centrifugal acceleration fields beyond 7251 times gravity of earth}, volume = {12}, year = {2025}, }
• (2025). Mechanisms of baicalin alleviates intestinal inflammation: Role of m1 macrophage polarization and lactobacillus amylovorus. ADVS, 12(21), 2415948. (www)

  @article{ , abstract = {Baicalin has been widely used for its anti-inflammatory pharmacological properties, yet its effects on bacterial intestinal inflammation and the mechanisms remain unclear. This study revealed that baicalin alleviates bacterial intestinal inflammation through regulating macrophage polarization and increasing Lactobacillus amylovorus abundance in colon. Specifically, transcriptomic analysis showed that baicalin restored Escherichia coli -induced genes expression changes including T helper cell 17 differentiation-related genes, macrophage polarization related genes, and TLR/IRF/STAT signaling pathway. Subsequent microbial and non-targeted metabolomic analysis revealed that these changes may be related to the enhancement of Lactobacillus amylovorus and the upregulation of its metabolites including chrysin, lactic acid, and indoles. Furthermore, whole-genome sequencing of Lactobacillus amylovorus provided insights into its functional potential and metabolic annotations. Lactobacillus amylovorus supplementation alleviates Escherichia coli -induced intestinal inflammation in mice and similarly inhibited M1 macrophage polarization through TLR4/IRF/STAT pathway. Additionally, baicalin, Lactobacillus amylovorus , or chrysin alone could regulate macrophage polarization, highlighting their independent anti-inflammatory potential. Notably, this study revealed that baicalin alleviates intestinal inflammation through TLR4/IRF/STAT pathway and increasing Lactobacillus amylovorus abundance and the synthesis of chrysin. These findings provide new insights into the therapeutic potential of baicalin and Lactobacillus amylovorus in preventing and treating intestinal inflammation, offering key targets for future interventions.}, archive = {J_ADVS}, author = {Shunfen Zhang and Ruqing Zhong and Miao Zhou and Kai Li and Huiyuan Lv and Huixin Wang and Ye Xu and Dadan Liu and Qiugang Ma and Liang Chen and Hongfu Zhang}, doi = {10.1002/advs.202415948}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415948}, shortjournal = {Adv. Sci.}, title = {Mechanisms of baicalin alleviates intestinal inflammation: Role of m1 macrophage polarization and lactobacillus amylovorus}, volume = {12}, year = {2025}, }
• (2025). An off-the-shelf artificial proregenerative macrophage for pressure ulcer treatment. ADVS, 12(21), 2415886. (www)

  @article{ , abstract = {Cell therapy is a promising approach in regenerative medicine. However, maintaining the survival and function of injected or implanted therapeutic cells remains a substantial challenge to success. In vivo modulatory strategy for cell therapeutics has been recently developed, but suffers from limited regenerative efficacy in injured tissue microenvironment with chronic inflammation. Here, an off-the-shelf artificial macrophage (artM) assembled by M2 macrophages-derived lysate proteins-loaded poly (lactic-co-glycolic acid) (PLGA) microspheres coated by macrophage cell membrane is developed. The synthetic artM fabricated in batches maintains its bioactivity with long-term cryostorage. Significantly, artM recapitulates the essential inflammation-regulatory and proregenerative characteristics of endogenous macrophages, including initiating M2 macrophage polarization, resolving excessive inflammation by releasing anti-inflammatory cytokines and growth factors, neutralizing endotoxins and proinflammatory cytokines, augmenting T-helper 2 (T H 2) immune response, and coordinating cell migration and proliferation. In mouse model of deep tissue pressure injury (DTPI), the artM induces tissue regeneration by modulating the inflammatory microenvironment, promoting angiogenesis, reducing scar deposition, and accelerating the renewal of skin appendages. Depletion of macrophages in mice with skin ulcers highlights the immunomodulatory and proangiogenic functions of artM as effective as autogenous macrophages. Collectively, the engineered artM represents a cell-free, proreparative alternative to immune cell therapy in chronic wound management.}, archive = {J_ADVS}, author = {Qi Su and Jingrong Wang and Yini Huangfu and Rui Gao and Pengxu Kong and Yu Gao and Huijuan Song and Ju Zhang and Pingsheng Huang and Chuangnian Zhang and Zujian Feng and Deling Kong and Weiwei Wang}, doi = {10.1002/advs.202415886}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415886}, shortjournal = {Adv. Sci.}, title = {An off-the-shelf artificial proregenerative macrophage for pressure ulcer treatment}, volume = {12}, year = {2025}, }
• (2025). Unraveling the interfacial properties of twisted single-crystal Au(111)/MoS2 heterostructures: A pathway to robust superlubricity. ADVS, 12(21), 2415884. (www)

  @article{ , abstract = {A comprehensive study of monolayer MoS 2 on a single-crystal Au(111) surface is reported, combining ultra-high vacuum scanning probe microscopy with advanced computational methods. Kelvin probe force microscopy precisely quantified the work function of the heterointerface, while topographic analysis by contact and non-contact atomic force microscopy revealed a moiré superlattice with an interfacial twist angle of 0.45° between MoS 2 and Au(111). To accurately model and predict the twist angle and out-of-plane corrugation of these moiré superlattices, a semi-anisotropic interlayer force field based on density functional theory is developed. This avoids the limitations of conventional pairwise potentials, and our results show excellent agreement with experiments. Furthermore, friction simulations revealed a non-monotonic dependence on the interfacial twist angle, with small angles exhibiting unexpectedly large shear stress, suggesting that MoS 2 could serve as an effective superlubric coating for gold. This work establishes a robust framework for the investigation of van der Waals heterostructures, bridging nanoscale experimental observations with first-principles calculations, and providing insights for the design of novel nanoscale devices with tailored electronic, mechanical, and tribological properties.}, archive = {J_ADVS}, author = {Yuanpeng Yao and Yiming Song and Bozhao Wu and Sebastian Scherb and Shuyu Huang and Antoine Hinaut and Thilo Glatzel and Ernst Meyer and Ze Liu and Wengen Ouyang}, doi = {10.1002/advs.202415884}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415884}, shortjournal = {Adv. Sci.}, title = {Unraveling the interfacial properties of twisted single-crystal Au(111)/MoS2 heterostructures: A pathway to robust superlubricity}, volume = {12}, year = {2025}, }
• (2025). Improving adult vision through pathway-specific training in augmented reality. ADVS, 12(21), 2415877. (www)

  @article{ , abstract = {Neurodevelopmental and neurodegenerative disorders are often associated with selective deficits in the parallel pathways of the human visual system. Effective intervention of the visual deficits is crucial for improving treatment outcomes and prognosis. In this study, a novel altered reality (AR) method is developed to improve pathway-specific functions in human adults with normal vision and amblyopia, a common developmental vision disorder. To selectively enhance the parvocellular pathway, which is notably impaired in amblyopia, the low spatial frequency (SF) components of visual input are phase-scrambled into fast-flickering noise, while the high SF details remained intact. In normal participants, short-term adaptation to this altered naturalistic environment led to selective enhancement of high SF sensitivity and visual acuity. Long-term adaptation to a dichoptically modified environment produced long-lasting improvement of high SF sensitivity and dominance of the weaker eye, with enhanced neural responses to high SF naturalistic stimuli. After one week of training with wearable AR glasses at home, amblyopic adults showed high treatment compliance and significant gains in visual acuity and dominance of the amblyopic eye, as well as in stereopsis. This AR-based, pathway-specific training method can be effective for improving visual functions in both healthy adults and patients with visual disorders.}, archive = {J_ADVS}, author = {Yige Gao and Yulian Zhou and Qing He and Wen Wen and Peng Zhang}, doi = {10.1002/advs.202415877}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415877}, shortjournal = {Adv. Sci.}, title = {Improving adult vision through pathway-specific training in augmented reality}, volume = {12}, year = {2025}, }
• (2025). Asprosin-FABP5 interaction modulates mitochondrial fatty acid oxidation through PPARα contributing to MASLD development. ADVS, 12(21), 2415846. (www)

  @article{ , abstract = {Alterations in liver metabolism play a pivotal role in the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Asprosin is reported to be released from white adipose tissue during fasting and targets the liver. However, the role of asprosin, especially from organs other than adipose tissue, in MASLD remains poorly understood. These findings demonstrate that plasma asprosin levels are significantly elevated in MASLD patients and animal models. Additionally, asprosin expression increased in the liver of MASLD mice. Hepatocyte-specific overexpression of asprosin impairs mitochondrial fatty acid β-oxidation (FAO), whereas its knockdown not only enhances FAO in mice but also compensates for fenofibrate's limitations in MASLD treatment. Mechanistic investigations reveal that the interaction of asprosin with FABP5 facilitates its abnormal nuclear localization, and asprosin directly bound to and inhibites peroxisome proliferator-activated receptor elements (PPREs), which negatively regulated PPARα transcriptional activity, and disrupts hepatic FAO pathways. GalNAc-siRNAs targeting hepatic FABP5 ameliorate hepatic steatosis. These findings reveal that the secretory adipose factor asprosin is expected to act as a biological marker for early clinical diagnosis and prognostic evaluation of MASLD. Moreover, targeting hepatic asprosin gene inhibition and GalNAc-siRNAs to inhibit hepatic FABP5 both offer potential therapeutic benefits in the treatment of MASLD.}, archive = {J_ADVS}, author = {Yuan-Yuan Yu and Min Feng and Yi Chen and Hong-Lin Jia and Qi Zhang and Ming Tong and Yan-Xi Li and Yu Zhao and Xin-Xin Liu and Shi-Feng Cao and Zheng-kai Wang and Hou-wei Li and Xue Liu and Yan Zhang}, doi = {10.1002/advs.202415846}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415846}, shortjournal = {Adv. Sci.}, title = {Asprosin-FABP5 interaction modulates mitochondrial fatty acid oxidation through PPARα contributing to MASLD development}, volume = {12}, year = {2025}, }
• (2025). Structural and biochemical characterization of a widespread enterobacterial peroxidase encapsulin. ADVS, 12(21), 2415827. (www)

  @article{ , abstract = {Encapsulins are self-assembling protein compartments found in prokaryotes and specifically encapsulate dedicated cargo enzymes. The most abundant encapsulin cargo class are Dye-decolorizing Peroxidases (DyPs). It has been previously suggested that DyP encapsulins are involved in oxidative stress resistance and bacterial pathogenicity due to DyPs’ inherent ability to reduce and detoxify hydrogen peroxide while oxidizing a broad range of organic co-substrates. Here, we report the structural and biochemical analysis of a DyP encapsulin widely found across enterobacteria. Using bioinformatic approaches, we show that this DyP encapsulin is encoded by a conserved transposon-associated operon, enriched in enterobacterial pathogens. Through low pH and peroxide exposure experiments, we highlight the stability of this DyP encapsulin under harsh conditions and show that DyP catalytic activity is highest at low pH. We determine the structure of the DyP-loaded shell and free DyP via cryo-electron microscopy, revealing the structural basis for DyP cargo loading and peroxide preference. This work lays the foundation to further explore the substrate range and physiological functions of enterobacterial DyP encapsulins.}, archive = {J_ADVS}, author = {Natalia C. Ubilla-Rodriguez and Michael P. Andreas and Tobias W. Giessen}, doi = {10.1002/advs.202415827}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415827}, shortjournal = {Adv. Sci.}, title = {Structural and biochemical characterization of a widespread enterobacterial peroxidase encapsulin}, volume = {12}, year = {2025}, }
• (2025). Insights into siglec-7 binding to gangliosides: NMR protein assignment and the impact of ligand flexibility. ADVS, 12(21), 2415782. (www)

  @article{ , abstract = {Gangliosides, sialylated glycosphingolipids abundant in the nervous system, play crucial roles in neurotransmission, interaction with regulatory proteins, cell–cell recognition, and signaling. Altered gangliosides expression has been correlated with pathological processes, including cancer, inflammatory disorders, and autoimmune diseases. Gangliosides are important endogenous ligands of Siglecs (Sialic acid-binding immunoglobulin-type lectins), I-type lectins mostly expressed by immune cells, that specifically recognize sialylated glycans. Siglec-7, an inhibitory immune receptor on human natural killer cells, represents a potential target for tumor immunotherapy. Notably, the expression of Siglec-7 ligands is high in various cancers, such as pancreatic cancer and melanoma and lead to tumor immune evasion. Siglec-7 binds the disialylated ganglioside GD3, a tumor-associated antigen overexpressed on cancer cells to suppress immune responses. Using a combination of structural biology techniques, including Nuclear Magnetic Resonance (NMR), biophysical, and computational methods, the binding of Siglec-7 to GD3 and Gb3 derivatives is investigated, revealing the importance of ligand conformation in modulating binding energetics and affinity. The greater flexibility of Gb3 derivatives appears to negatively impact binding entropy, leading to lower affinity compared to GD3. A thorough understanding of these interactions could contribute to elucidating molecular mechanisms of cancer immune evasion and facilitate the development of ganglioside-based diagnostic and therapeutic strategies for cancer.}, archive = {J_ADVS}, author = {Cristina Di Carluccio and Luis Padilla-Cortés and Marta Tiemblo-Martìn and Giulia Roxana Gheorghita and Rosario Oliva and Linda Cerofolini and Alessandro Antonio Masi and Celeste Abreu and Hsin-Kai Tseng and Antonio Molinaro and Pompea Del Vecchio and Ondřej Vaněk and Chun-Cheng Lin and Roberta Marchetti and Marco Fragai and Alba Silipo}, doi = {10.1002/advs.202415782}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415782}, shortjournal = {Adv. Sci.}, title = {Insights into siglec-7 binding to gangliosides: NMR protein assignment and the impact of ligand flexibility}, volume = {12}, year = {2025}, }
• (2025). Architecting a bias-free photoelectrochemical CO2 reduction system for sustainable formic acid. ADVS, 12(21), 2415774. (www)

  @article{ , abstract = {Solar-driven photoelectrochemical CO 2 reduction represents a promising approach for the production of renewable liquid fuel but is limited by low photocurrent, the need for an external bias, and low carbon efficiency. This work employs a TiO 2 -CdS/Se-ZnSe/S photoanode to drive the sulfur oxidation reaction, achieving a photocurrent density of 12.7 mAcm −2 under AM 1.5G illumination and with an 87% retention after 100 h of continuous operation. Furthermore, through tailoring the adsorption capability for the * OCHO intermediate, the Cu 6 Sn 5 catalyst exhibits a Faradaic efficiency of 92.8% for formic acid at −1.15 V in acidic media and maintains stability above 90% during a 120-h test. Finally, the constructed system achieves bias-free photoelectrochemical CO 2 reduction to HCOOH and delivers a yield of up to 172.9 µmolh −1 cm −2 over an 85-h long-term test, outperforming conventional solar-driven systems. These findings highlight a cost-effective strategy for solar-driven liquid fuel production and provide valuable design concepts and insights into the development of photoelectrochemical systems.}, archive = {J_ADVS}, author = {Yinchao Yao and Zilong Wu and Zhiwei Zhao and Zhiyi Sun and Tiesong Li and Zebiao Li and Xinxin Lu and Zhuo Chen}, doi = {10.1002/advs.202415774}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415774}, shortjournal = {Adv. Sci.}, title = {Architecting a bias-free photoelectrochemical CO2 reduction system for sustainable formic acid}, volume = {12}, year = {2025}, }
• (2025). Technoeconomic insights into metal hydrides for stationary hydrogen storage. ADVS, 12(21), 2415736. (www)

  @article{ , abstract = {Metal hydrides (MHs) are promising candidates for storing hydrogen at ambient conditions at high volumetric energy densities. Recent developments suggest hydride-based systems can cycle and operate at favorable pressures and temperatures that work well with fuel cells used in stationary power applications. In this study, we present a comprehensive design and cost analysis of MH-based long duration hydrogen storage facilities for a variety of power end users (0 to 20 megawatts (MW) supplied over 0 to 100 hours), to offer insights on technical targets for material development and operation strategies. Our findings indicate that hydride-based storage systems hold significant size advantage in physical footprint, requiring up to 65% less land than 170-bar compressed gas storage. Metal hydride systems can be cost competitive with 350-bar compressed gas systems, with TiFe 0.85 Mn 0.05 achieving $0.45/kWh and complex MH Mg(NH 2 ) 2 -2.1LiH-0.1KH achieving $0.38/kWh. Extending charging times and increasing operating cycles significantly reduce levelized cost of storage, especially for complex MHs. Key strategies to further enhance the competitiveness of MHs include leveraging waste heat from fuel cells, reducing use of critical minerals, and achieving MH production costs of US$10/kg.}, archive = {J_ADVS}, author = {Xinyi Wang and Peng Peng and Matthew D. Witman and Vitalie Stavila and Mark D. Allendorf and Hanna M. Breunig}, doi = {10.1002/advs.202415736}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415736}, shortjournal = {Adv. Sci.}, title = {Technoeconomic insights into metal hydrides for stationary hydrogen storage}, volume = {12}, year = {2025}, }
• (2025). SSRP1/SLC3A2 axis in arginine transport: A new target for overcoming immune evasion and tumor progression in peripheral T-cell lymphoma. ADVS, 12(21), 2415698. (www)

  @article{ , abstract = {Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of mature T-cell malignancies with poor prognosis. Therefore, improved therapies are urgently required to improve patient outcomes. In this study, metabolic inhibitor drug screening reveals that quinacrine elicits excellent antitumor activity both in vitro and in vivo by downregulating intracellular arginine levels in PTCL. Single-cell transcriptomic analyses reveal aberrant arginine metabolism in patients with PTCL, characterized by excessive solute carrier family 3 member 2 (SLC3A2) mediated arginine uptake preferentially in tumor cells. High SLC3A2 expression predicts poor outcomes in PTCL, as SLC3A2-mediated arginine uptake promotes the malignant behaviors of tumor cells and induces tumor immune escape, thereby fueling tumor progression. Mechanistically, high arginine levels induce global metabolic changes, including enhanced oxidative phosphorylation by promoting nascent RNA synthesis. This work identifies structure-specific recognition protein 1 (SSRP1), which upregulates SLC3A2, as a co-transcription factor with JUNB. Quinacrine disrupts SLC3A2-mediated arginine transport by targeting SSRP1. Combining quinacrine with histone deacetylase inhibitors is a promising therapeutic strategy for PTCL.}, archive = {J_ADVS}, author = {Yimin Ren and Lei Fan and Ling Wang and Yanping Liu and Jie Zhang and Boya Wang and Ruize Chen and Xiao Chen and Lingyu Zhuang and Yaping Zhang and Handong Sun and Jianyong Li and Wenyu Shi and Hui Jin}, doi = {10.1002/advs.202415698}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415698}, shortjournal = {Adv. Sci.}, title = {SSRP1/SLC3A2 axis in arginine transport: A new target for overcoming immune evasion and tumor progression in peripheral T-cell lymphoma}, volume = {12}, year = {2025}, }
• (2025). Enhancer extrachromosomal circular DNA ANKRD28 elicits drug resistance via POU2F2-mediated transcriptional network in multiple myeloma. ADVS, 12(21), 2415695. (www)

  @article{ , abstract = {Multiple myeloma (MM) remains an incurable disease primarily due to the emergence of drug resistance, and the underlying mechanisms remain unclear. Extrachromosomal circular DNAs (eccDNAs) are prevalent in cancer genomes of both coding and non-coding regions. However, the role of non-coding eccDNA regions that serve as enhancers has been largely overlooked. Here, genome-wide profiling of serum eccDNAs from donors and MM patients who responded well or poorly to bortezomib-lenalidomide-dexamethasone (VRd) therapy is characterized. A high copy number of eccDNA ANKRD28 (eccANKRD28) predicts poor therapy response and prognosis but enhanced transcriptional activity. Established VRd-resistant MM cell lines exhibit a higher abundance of eccANKRD28, and CRISPR/Cas9-mediated elevation of eccANKRD28 desensitizes bortezomib and lenalidomide treatment both in vitro and in vivo. Integrated multi-omics analysis (H3K27ac ChIP-seq, scRNA-seq, scATAC-seq, CUT&Tag, et al.) identifies eccANKRD28 as an active enhancer involved in drug resistance driven by the key transcription factor, POU class 2 homeobox 2 (POU2F2). POU2F2 interacts with sequence-specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes, including IRF4 , JUNB , IKZF3 , RUNX3, and BCL2 . This study elucidates the potential transcriptional network of enhancer eccANKRD28 in MM drug resistance from a previously unrecognized epigenetic perspective.}, archive = {J_ADVS}, author = {Binzhen Chen and Jia Liu and Yaoxin Zhang and Changming Shi and Di Zhu and Guoqiang Zhang and Fei Xiao and Lu Zhong and Minyue Zhang and Lai Guan Ng and Honghui Huang and Tingting Lu and Jian Hou}, doi = {10.1002/advs.202415695}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415695}, shortjournal = {Adv. Sci.}, title = {Enhancer extrachromosomal circular DNA ANKRD28 elicits drug resistance via POU2F2-mediated transcriptional network in multiple myeloma}, volume = {12}, year = {2025}, }
• (2025). A novel theranostic strategy for malignant pulmonary nodules by targeted CECAM6 with 89Zr/131I-labeled tinurilimab. ADVS, 12(21), 2415689. (www)

  @article{ , abstract = {Lung adenocarcinoma (LUAD) constitutes a major cause of cancer-related fatalities worldwide. Early identification of malignant pulmonary nodules constitutes the most effective approach to reducing the mortality of LUAD. Despite the wide application of low-dose computed tomography (LDCT) in the early screening of LUAD, the identification of malignant pulmonary nodules by it remains a challenge. In this study, CEACAM6 (also called CD66c) as a potential biomarker is investigated for differentiating malignant lung nodules. Then, the CEACAM6-targeting monoclonal antibody (mAb, tinurilimab) is radiolabeled with 89 Zr and 131 I for theranostic applications. In terms of diagnosis, machine learning confirms CEACAM6 as a specific extracellular marker for discrimination between LUAD and benign nodules. The 89 Zr-labeled mAb is highly specific uptake in CEACAM6-positive LUAD via positron emission tomography (PET) imaging, and its ability to distinguish in malignant pulmonary nodules are significantly higher than that of 18 F Fluorodeoxyglucose (FDG) by positron emission tomography/magnetic resonance (PET/MR) imaging. While the 131 I-labeled mAb serving as the therapeutic aspect has significantly suppressed tumor growth after a single treatment. These results proves that 89 Zr/ 131 I-labeled tinurilimab facilitates the differential capacity of malignant pulmonary nodules and radioimmunotherapy of LUAD in preclinical models. Further clinical evaluation and translation of this CEACAM6-targeted theranostics may be significant help in diagnosis and treatment of LUAD.}, archive = {J_ADVS}, author = {Chongyang Chen and Keying Zhu and Jing Wang and Donghui Pan and Xinyu Wang and Yuping Xu and Junjie Yan and Lizhen Wang and Min Yang}, doi = {10.1002/advs.202415689}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415689}, shortjournal = {Adv. Sci.}, title = {A novel theranostic strategy for malignant pulmonary nodules by targeted CECAM6 with 89Zr/131I-labeled tinurilimab}, volume = {12}, year = {2025}, }
• (2025). IR783-stabilized nanodrugs enhance anticancer immune response by synergizing oxidation therapy and epigenetic modulation. ADVS, 12(21), 2415684. (www)

  @article{ , abstract = {Immune evasion and metastasis are the leading causes of poor prognosis in triple-negative breast cancer treatment. Since current standard immunotherapies have limited efficacy due to immunologically cold microenvironment, it is crucial to explore new strategies to sensitize anticancer immune response. In this study, it is found that incorporating β -lapachone-based oxidation therapy with CUDC101-initiated epigenetic regulation results in synergistic antitumor effects and potent immune activation. To co-deliver these two hydrophobic drugs, IR783 with cyanine structure serves as the stabilizer to form a nanoformulation based on small molecule self-assembly. Such IR783-stabilized nanodrugs can not only lead to cancer cell apoptosis through HDAC inhibition-enhanced oxidation therapy but also cooperatively induce immunogenic cell death and promote pro-inflammatory cytokine gene expression to reshape immunosuppressive microenvironment. Besides, nanodrugs can inhibit both primary and distant tumor growth effectively by elevating systemic anticancer immunity. This study provides a promising approach to synergize oxidation therapy with epigenetic modulation for safe and efficient breast cancer immunotherapy.}, archive = {J_ADVS}, author = {Jinzhao Liu and Meicen Wu and Qingyang Lyu and Chang Yang and Ni Fan and Kang Chen and Weiping Wang}, doi = {10.1002/advs.202415684}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415684}, shortjournal = {Adv. Sci.}, title = {IR783-stabilized nanodrugs enhance anticancer immune response by synergizing oxidation therapy and epigenetic modulation}, volume = {12}, year = {2025}, }
• (2025). Deciphering the metabolic impact and clinical relevance of N-glycosylation in colorectal cancer through comprehensive glycoproteomic profiling. ADVS, 12(21), 2415645. (www)

  @article{ , abstract = {Colorectal cancer (CRC) progression is driven by complex metabolic alterations, including aberrant N-glycosylation patterns that critically influence tumor development. However, the metabolic and functional roles of N-glycosylation in CRC remain poorly understood. Herein, comprehensive proteomic and N-linked intact glycoproteomics analyses are performed on 45 CRC tumors, and normal adjacent tissues (NATs) are matched, identifying 7125 intact N-glycopeptides from 704 glycoproteins. Through analysis of glycoform expression profiles and structural characteristics, a glycosylation site–protein function association network is constructed to uncover metabolic dysregulation driven by N-glycosylation in CRC. Moreover, an arithmetic model is developed that integrates N-glycan expression patterns, which effectively distinguishes tumors from NATs, reflecting metabolic reprogramming in cancer. These findings identify Chloride Channel Accessory 1 (CLCA1) and Olfactomedin 4 (OLFM4) as potential metabolic biomarkers for CRC diagnosis. Immunohistochemistry and Cox regression analyses validated the prognostic power of these markers. Notably, the critical role of specific N-glycosylation at N196 of Adipocyte plasma membrane-associated protein (APMAP) is highlighted, a key player in tumor metabolism and CRC progression, providing a potential target for therapeutic intervention. These findings offer valuable insights into the metabolic roles of N-glycosylation in CRC, advancing biomarker discovery, enhancing metabolic-based diagnostic precision, and improving personalized treatment strategies targeting cancer metabolism.}, archive = {J_ADVS}, author = {Guobin Liu and Lu Chen and Jingxiang Zhao and Yue Jiang and Yarong Guo and Xiang Mao and Xuelian Ren and Kun Liu and Qi Mei and Qunyi Li and He Huang}, doi = {10.1002/advs.202415645}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415645}, shortjournal = {Adv. Sci.}, title = {Deciphering the metabolic impact and clinical relevance of N-glycosylation in colorectal cancer through comprehensive glycoproteomic profiling}, volume = {12}, year = {2025}, }
• (2025). Reinforced granular hydrogels scaffolds with tunable physicochemical properties for advanced skin tissue engineering. ADVS, 12(21), 2415634. (www)

  @article{ , abstract = {Engineering bioscaffolds with tailored architectures and optimized physicochemical properties remains a crucial yet challenging goal in tissue engineering and regenerative medicine. In this study, the design of reinforced concrete-inspired annealed granular hydrogel (GH) scaffolds that meet the essential yet often conflicting requirements for bioscaffolds: providing adequate mechanical strength while facilitating cell infiltration, nutrient exchange, and the formation of complex cellular networks. GH building blocks are synthesized using a binary macromonomer system of hyperbranched polyethylene glycol and thiolated gelatin within microfluidic droplets, benefiting from the molecular interface assembly and templating effects of the microdroplets, which possess highly reactive vinyl functional groups, thereby endowing the annealed GH scaffolds with highly customizable properties. The versatility of this platform is demonstrated by the creation of full-thickness engineered skin tissues that support keratinocyte attachment and differentiation; the formation of a mature epidermis, complete with a developed stratum corneum, and the expression of key markers, such as keratin 10 and keratin 14, while minimizing contraction over long-term culturing, a common limitation of traditional collagen-based scaffolds. Owing to their biocompatibility, tunable mechanical properties, ease of surface functionalization, and compatibility with bioprinting, these scaffolds have significant potential for applications in tissue engineering, drug delivery, and bioprinting.}, archive = {J_ADVS}, author = {Jing Zhang and Yijia Wang and Yue Liu and Guanfu Wu and Guilong Lu and Yue Li and Yu Shen and Caifeng Wang and Mehdi Khanmohammadi and Wojciech Święszkowski and Jing Wang and Ziyi Yu}, doi = {10.1002/advs.202415634}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415634}, shortjournal = {Adv. Sci.}, title = {Reinforced granular hydrogels scaffolds with tunable physicochemical properties for advanced skin tissue engineering}, volume = {12}, year = {2025}, }
• (2025). A facile strategy to restore the optic nerve functionality using an injectable conducting hydrogel. ADVS, 12(21), 2415601. (www)

  @article{ , abstract = {This study introduces a novel injectable conductive polymer hydrogel from poly(3,4-ethylenedioxythiophene) (PEDOT). This hydrogel is designed to facilitate the recovery of electrophysiological function in injured optic nerves. The hydrogel can be injected directly at the injury site and spontaneously gel in place. These findings indicate a remarkable restoration of electrophysiological function, with a two to fourfold increase in amplitude (N1-P1 wavelet) of flash visual evoked potentials. Electroretinography results further support that both a-wave and b-wave amplitudes obtained under various adaptation conditions in the PEDOT hydrogel-treated animal models with optic nerve crush are comparable to those in the control group. The visual cliff testing results further supports the enhanced visual functionality after the hydrogel treatment. This improvement signifies enhanced responsiveness to light stimulation and a substantial boost in axonal transmission of visual information. Additionally, the injection of PEDOT hydrogel significantly mitigates the apoptosis of retinal ganglion cells, resulting in a fourfold increase in their survival rate. The ease of preparation and outstanding performance in vivo make it a promising bioengineered material for optic nerve research. This advancement offers new hope for patients with traumatic optic neuropathy, potentially leading to improved treatments and outcomes in optic nerve regeneration.}, archive = {J_ADVS}, author = {Changchun Yu and Yandi Zhou and Shuang Yao and Ziyi Wang and Sihao Ye and Rubing Qi and Hai Hu and Keke Liu and Yabo Wu and Tom Lawson and Lu Yan and Yong Liu and Wencan Wu}, doi = {10.1002/advs.202415601}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415601}, shortjournal = {Adv. Sci.}, title = {A facile strategy to restore the optic nerve functionality using an injectable conducting hydrogel}, volume = {12}, year = {2025}, }
• (2025). In vivo reprogramming of tissue-derived extracellular vesicles for treating chronic tissue injury through metabolic engineering. ADVS, 12(21), 2415556. (www)

  @article{ , abstract = {Extracellular vesicles (EVs) have emerged as promising therapeutics for regenerative medicine, but the efficacy of current exogenous EV-based therapies for treating chronic tissue injury is still unsatisfactory. Exercise can affect skeletal muscle EV secretion and that this process regulates the systemic health-promoting role of exercise, suggesting that fine-tuning of endogenous tissue EV secretion may provide a new therapeutic avenue. Here, this work reports that in vivo reprogramming of EV secretion via metabolic engineering is a promising strategy for treating chronic diseases. Briefly, exercise enhanced mitochondrial metabolism and EV production in healthy skeletal muscles, and EVs from healthy skeletal muscles subjected to exercise or metabolic engineering (boosting mitochondrial biogenesis via AAV-mediated muscle-specific TFAM overexpression) exerted cellular protective effects in vitro. In injured skeletal muscles, in vivo metabolic engineering therapy could reprogram EV secretion patterns (reducing pathological EV compositions while increasing beneficial EV compositions) by regulating multiple EV biogenesis and cargo sorting pathways. Reprogrammed muscle-derived EVs could reach major organs and tissues via the circulation and then simultaneously attenuated multiple-tissue (e.g., muscle and kidney) injury in chronic kidney disease. This study highlights that in vivo reprogramming of tissue-derived EVs via a metabolic engineering approach is a potential strategy for treating diverse chronic diseases.}, archive = {J_ADVS}, author = {Meng Zhao and Shuyun Liu and Yizhuo Wang and Peng Lou and Ke Lv and Tian Wu and Lan Li and Qianyi Wu and Jiaying Zhu and Yanrong Lu and Meihua Wan and Jingping Liu}, doi = {10.1002/advs.202415556}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415556}, shortjournal = {Adv. Sci.}, title = {In vivo reprogramming of tissue-derived extracellular vesicles for treating chronic tissue injury through metabolic engineering}, volume = {12}, year = {2025}, }
• (2025). High sugar induced RCC2 lactylation drives breast cancer tumorigenicity through upregulating MAD2L1. ADVS, 12(21), 2415530. (www)

  @article{ , abstract = {Lactylation is a novel post-translational modification mediated by lactate, widely present in the lysine residues of both histone and non-histone proteins. However, the specific regulatory mechanisms and downstream target proteins remain unclear. Herein, it is demonstrated that the RCC2 protein may serve as a critical link between material metabolism and cell division, promoting the rapid proliferation of breast cancer under high glucose conditions. Mechanistically, the activation of glycolysis leads to an increase in lactate. Then, acyltransferase KAT2A mediates RCC2 lactylation at K124, which assists RCC2 in recruiting free SERBP1, thereby stabilizing MAD2L1 mRNA. The lactylation of RCC2 mediates the activation of the cellular MAD2L1 signaling pathway and contributes to the progression of breast cancer. A small molecule inhibitor slows down cell proliferation by binding to the RCC2 active pocket and specifically blocking RCC2 lactylation. The findings elucidate the mechanism behind the upregulation of MAD2L1 in murine tumors associated with a high-sugar diet as reported in prior study and suggest a novel therapeutic strategy of targeting RCC2 lactylation to restrict the rapid proliferation of breast cancer cell in a high-lactate microenvironment.}, archive = {J_ADVS}, author = {Bowen Zheng and Yunhao Pan and Fengyuan Qian and Diya Liu and Danrong Ye and Bolin Yu and Seng Zhong and Wenfang Zheng and Xuehui Wang and Baian Zhou and Yuying Wang and Lin Fang}, doi = {10.1002/advs.202415530}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415530}, shortjournal = {Adv. Sci.}, title = {High sugar induced RCC2 lactylation drives breast cancer tumorigenicity through upregulating MAD2L1}, volume = {12}, year = {2025}, }
• (2025). An insect salivary sheath protein triggers plant resistance to insects and pathogens as a conserved HAMP. ADVS, 12(21), 2415474. (www)

  @article{ , abstract = {Herbivore-associated molecular patterns (HAMPs) in saliva enable plants to detect herbivores and activate pattern-triggered immunity (PTI). Piercing-sucking herbivores secrete gel saliva, forming salivary sheaths that assist in feeding, however, the role of proteins within these sheaths in modulation of plant defenses remains poorly understood. Here, a thermostable HAMP, myosin light chain 1-like (myosin) is identified, from the salivary sheath of the small brown planthopper (SBPH) Laodelphax striatellus. Myosin is a widely conserved arthropod protein, and acts as an elicitor of BAK1-dependent PTI responses in several plant species. Plants are able to specifically recognize the myosin 41-amino-acid peptide (MP41), which acts as a minimal immunogenic epitope. Furthermore, myosin and MP41 stimulate jasmonic acid and H 2 O 2 production in rice. The resulting defenses not only diminish planthopper performance directly but also induce volatile emissions, attracting a common parasitoid. Additionally, expression of myosin in rice increased plant resistance to a chewing insect as well as to viral and fungal pathogens. However, silencing myosin in SBPH resulted in disruption of salivary sheath formation, reducing insect feeding efficiency. This study demonstrates that myosin from the SBPH salivary sheath serves as a critical and unavoidable HAMP, triggering broad-spectrum plant resistance to various insects and pathogens.}, archive = {J_ADVS}, author = {Liangxuan Qi and Jing Li and Shuai Li and Han Wang and Lei Yang and Xinyang Tan and Zhichang Zhao and Guanghua Luo and Maofeng Jing and Ary A. Hoffmann and Jichao Fang and Rui Ji}, doi = {10.1002/advs.202415474}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415474}, shortjournal = {Adv. Sci.}, title = {An insect salivary sheath protein triggers plant resistance to insects and pathogens as a conserved HAMP}, volume = {12}, year = {2025}, }
• (2025). Oxytocin improves autistic behaviors by positively shifting GABA reversal potential via NKCC1 in early-postnatal-stage. ADVS, 12(21), 2415432. (www)

  @article{ , abstract = {Accumulating evidence has identified disrupted oxytocin signaling in both autistic patients and animal models of autism. Nevertheless, the specific timing of the impact of oxytocin on social behavior has remained unclear. Using mouse strains from oxytocin-Cre mice crossed with Cre-dependent chemogenetic mice, oxytocinergic neuronal activity is selectivity manipulated during the early or late postnatal stages and revealed, for the first time, that the suppression of oxytocinergic neurons in the early rather than late postnatal stage led to the emergence of autistic-like behaviors. Notably, significantly reduced oxytocin levels are identified specifically during the early postnatal stage in both valproic acid (VPA)-exposed and Fmr1 -KO mouse brains, along with an impairment of the GABA reversal potential and downregulation of the Na + -K + -2Cl − cotransporter (NKCC1) post-birth. Furthermore, chemogenetic activation of oxytocinergic neurons during the early rather than late postnatal stage effectively restored the aberrant NKCC1 expression and GABA A receptor reversal potential and consequently alleviated autistic-like behaviors in VPA-exposed mice. Overall, the results demonstrate that the early postnatal stage may be the unique critical period for oxytocin signaling to regulate GABA reversal potential and promote brain development for prosocial behaviors. These findings suggest an earlier intervention window and strategy for the clinical oxytocin treatment of autism.}, archive = {J_ADVS}, author = {Zi-Hui Wang and Chang Xu and Yao-Yao Ma and Wei-Xuan Xue and Hao-Yuan Wang and Lin-Yao Fan and Chen-Yu Zhang and Liang Li and Xiao-Yang Zhang and Jing-Ning Zhu and Qi-Peng Zhang}, doi = {10.1002/advs.202415432}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415432}, shortjournal = {Adv. Sci.}, title = {Oxytocin improves autistic behaviors by positively shifting GABA reversal potential via NKCC1 in early-postnatal-stage}, volume = {12}, year = {2025}, }
• (2025). Confined migration drives stem cell differentiation. ADVS, 12(21), 2415407. (www)

  @article{ , abstract = {In both endogenous and exogenously-introduced human mesenchymal stem cells (hMSCs), homing to sites of regeneration requires navigation through complex extracellular matrix environments that impose confinement on migrating cells. Despite its prevalence in vivo, the impact of confinement on hMSC differentiation remains poorly understood. To address these questions, a physiologically relevant, flow-free polydimethylsiloxane-based microchannel system with confining widths ranging from 3 to 10 µm in width, is developed. In these microchannel systems, it is found that hMSCs migrate faster and experience significant nuclear deformation in 3 µm wide channels compared to wider 10 µm channels. These morphological changes persist for days postexit, implying that stem cells possess a mechanical memory of their past confined migration. High degrees of nuclear deformation also correlated with substantial changes in genome regulation, as cells displayed significant H3K9 acetylation postconfinement. In these postconfinement stem cells, significantly higher expression levels of RUNX2 along with a higher degree of nuclear-to-cytoplasmic shuttling are found, suggesting that short confined migration can stimulate osteogenic differentiation. Finally, it is found that nuclear mechanosensing via the cytoskeleton is not the primary factor driving confinement-induced differentiation. These results suggest that physiological confinement can serve as a key mechanical cue promoting early osteogenic differentiation in hMSCs.}, archive = {J_ADVS}, author = {Xu Gao and Yixuan Li and Jia Wen Nicole Lee and Jianxuan Zhou and Vaishnavi Rangaraj and Jennifer Marlena and Andrew W. Holle}, doi = {10.1002/advs.202415407}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415407}, shortjournal = {Adv. Sci.}, title = {Confined migration drives stem cell differentiation}, volume = {12}, year = {2025}, }
• (2025). A transition metal-free approach for the conversion of real-life cellulose-based biomass into formate. ADVS, 12(21), 2415339. (www)

  @article{ , abstract = {Formic acid (FA) and its salt are recognized as valuable molecules for various industries such as textiles and pharmaceuticals. Currently, the global demand of FA and its salts stands at 1.137 million metric tons per year, necessitating the development of sustainable methods to meet the future demands. While numerous approaches are developed for the generation of FA but the requirement of harsh reaction conditions to achieve them is unavoidable. On the other hand, the world production of biomass is estimated at 146 billion metric tons per year and that can be considered as a prospective source of FA and their salts. Additionally, cellulose accounts for approximately 35–45% of the biomass composition. Considering this, a visible-light-mediated approach is presented to produce formate directly from biomass at room temperature as well as at atmospheric pressure. In this approach, selective generation of hydroxyl radical has been achieved which later converted sugars, cellulose, and hemicellulose into formate. Furthermore, the conversion of cellulose-rich daily-life materials such as discarded paper into the product through a series of flow experiments is demonstrated. Finally, mechanistic investigations including electron paramagnetic resonance (EPR) spectroscopy, and density functional theory (DFT) calculations are conducted to gain insights into the underlying reaction mechanism.}, archive = {J_ADVS}, author = {Tong Zhang and Peng Ren and Yuman Qin and Thanh Huyen Vuong and Ana V. Cunha and Remco W. A. Havenith and Jabor Rabeah and Shoubhik Das}, doi = {10.1002/advs.202415339}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415339}, shortjournal = {Adv. Sci.}, title = {A transition metal-free approach for the conversion of real-life cellulose-based biomass into formate}, volume = {12}, year = {2025}, }
• (2025). Accelerating electrochemical responses of Na4VMn(PO4)3 via bulk-defects and architecture engineering for high-performance sodium-ion batteries. ADVS, 12(21), 2415331. (www)

  @article{ , abstract = {Manganese-based NASICON-type Na 4 VMn(PO 4 ) 3 (NVMP) has captured widespread attention in sodium-ion batteries (SIBs) due to its abundant reserves and high operating voltages. However, the low intrinsic conductivity and detrimental Jahn–teller (J–T) effect impedes its electron and ion transfer, leading to rapid structural degradation and capacity decay. Herein, a facile multiscale coupling strategy is proposed to synthesize the nanosheet-stacked rods (NVMP-NSRs) with rational defects for improving intrinsic conductivity and structural stability, thus accelerating electrochemical responses. Localized unsaturated coordination states around vanadium atoms in NVMP-NSRs are also regulated, further facilitating rapid Na + diffusion with relieved volume expansion due to the unique architecture design. Density functional theory (DFT) calculations reveal highly rearranged interfacial charges, yielding benefits for reducing the energy barriers of Na + migration. The innovative NVMP-NSRs with appropriate bulk defects exhibit considerable discharge capacity (120.1 mAh g −1 at 0.5C), high-rate performance (70.9 mAh g −1 at 30C), and negligible capacity decay (3000 cycles at 20C). Moreover, the assembled NVMP-NSRs//hard carbon full cells demonstrate a high energy density of 391.1 Wh kg −1 with excellent cyclic stability (91.2% after 100 cycles at 1C). The multiscale coupling strategy in this work offers new avenues to design high-performance electrode materials toward fast electrochemical responses and robust structural stability.}, archive = {J_ADVS}, author = {Jingwen Zhao and Bo Zou and Weitao Yan and Shijia Li and Wentao Wu and Wei-Hua Wang and Shiyu Li and Ying Bai}, doi = {10.1002/advs.202415331}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415331}, shortjournal = {Adv. Sci.}, title = {Accelerating electrochemical responses of Na4VMn(PO4)3 via bulk-defects and architecture engineering for high-performance sodium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Diallyl trisulfide from garlic regulates RAB18 phase separation to inhibit lipophagy and induce cuproptosis in hepatic stellate cells for antifibrotic effects. ADVS, 12(21), 2415325. (www)

  @article{ , abstract = {Liver fibrosis, a common pathological process, severely impacts human health, yet effective treatments are lacking. Cuproptosis, a newly discovered form of cell death induced by copper ions, triggers cytotoxic stress through lipoylated protein oligomerization and may offer a novel therapeutic strategy for liver fibrosis. However, the mechanisms underlying cuproptosis in liver fibrosis are not well understood. During liver fibrosis progression, hepatic stellate cells (HSCs) activate, proliferate, and secrete extracellular matrix components, contributing to fibrosis. Activated HSCs also undergo lipophagy, the degradation of lipid droplets. The study shows that Ras-related protein Rab-18 (RAB18), a protein involved in lipid metabolism, inhibits lipophagy, upregulates Carnitine palmitoyltransferase 1A (CPT1A), and promotes succinylation of dihydrolipoamide dehydrogenase (DLD) at site K320, triggering cuproptosis in HSCs. Diallyl trisulfides (DATs), a garlic-derived compound, induces phase separation of RAB18 and promotes mitochondrial-associated membrane structures (MAMs) formation, further accelerating RAB18 phase separation. DATs selectively protects hepatocytes while activating cuproptosis in HSCs. Interfering with RAB18 expression reverses the DATs-induced inhibition of lipophagy and cuproptosis. These findings, confirmed in primary cells, human liver stellate cells (LX2), rodent models and clinical samples, suggest that DATs, by targeting RAB18 and inducing its phase separation, subsequently inhibit lipophagy and promote cuproptosis, making it a promising therapeutic approach for liver fibrosis. [Correction added on 02 May 2025, after first online publication: In line 4 of the abstract, “sulfenylated” was updated to “lipoylated”.]}, archive = {J_ADVS}, author = {Haoyuan Tian and Shujiang Sun and Xinran Qiu and Junrui Wang and Yuanyuan Gao and Jianmei Chen and Xiang Han and Zhengyang Bao and Xiaohan Guo and Yuqi Sun and Yuxin Lin and Mengru Hu and Feng Zhang and Zili Zhang and Feixia Wang and Shizhong Zheng and Jiangjuan Shao}, doi = {10.1002/advs.202415325}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415325}, shortjournal = {Adv. Sci.}, title = {Diallyl trisulfide from garlic regulates RAB18 phase separation to inhibit lipophagy and induce cuproptosis in hepatic stellate cells for antifibrotic effects}, volume = {12}, year = {2025}, }
• (2025). MeCP2 lactylation protects against ischemic brain injury by transcriptionally regulating neuronal apoptosis. ADVS, 12(21), 2415309. (www)

  @article{ , abstract = {Lactate plays diverse roles in brain pathophysiology, including ischemic stroke. Here, the role of lysine lactylation, an epigenetic modification of lactate, in cerebral ischemia is investigated. Using a mouse model of transient middle cerebral artery occlusion, increased brain lactate levels and global protein lactylation are observed. Proteomics analysis reveals significant lactylation of non-histone proteins in the ischemic penumbra. Lactylation of MeCP2, a transcriptional regulator, is identified as a protective mechanism against stroke-induced neuronal death. Inhibition of MeCP2 lactylation through chemical or genetic manipulation increases infarct volume and aggravates neurological deficits. Mechanistically, MeCP2 lactylation at K210/K249 represses the transcription of apoptosis-associated genes, including Pdcd4 and Pla2g6 , thereby attenuating neuronal apoptosis. Additionally, HDAC3 and p300 are identified as key enzymes that regulate MeCP2 lactylation post-stroke. The findings suggest that MeCP2 lactylation offers a potential therapeutic target for alleviating neuronal damage and improving stroke outcomes.}, archive = {J_ADVS}, author = {Min Sun and Yuxin Zhang and Rui Mao and Yan Chen and Pinyi Liu and Lei Ye and Siyi Xu and Junqiu Jia and Shu Shu and Huiya Li and Yanping Yin and Shengnan Xia and Yanting Chen and Yun Xu}, doi = {10.1002/advs.202415309}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415309}, shortjournal = {Adv. Sci.}, title = {MeCP2 lactylation protects against ischemic brain injury by transcriptionally regulating neuronal apoptosis}, volume = {12}, year = {2025}, }
• (2025). MMP9High neutrophils are critical mediators of neutrophil extracellular traps formation and myocardial Ischemia/Reperfusion injury. ADVS, 12(21), 2415205. (www)

  @article{ , abstract = {Neutrophil extracellular traps (NETs) are increasingly recognized as pivotal players and potential therapeutic targets in neutrophil-mediated reperfusion injury. Despite their importance, the effects and variability of circulating neutrophils in relation to NET formation during myocardial ischemia/reperfusion injury (MI/RI) remain inadequately characterized. In this study, single-cell transcriptomes of neutrophils isolated from the blood of healthy donors and MI/RI patients are analyzed. The results reveal that MI/RI neutrophils transition from a high IFIT1 expression profile into four distinct states, two of which exhibit elevated MMP9 transcription. These MMP9 High neutrophil subpopulations are instrumental in the NET formation and correlate positively with the severity of MI/RI. Further investigation identifies the transcription factor SPI1 as a key regulator of this transition, acting through modulation of CST7 expression. Targeting SPI1 or CST7 significantly reduces the prevalence of MMP9 High neutrophils and NET formation, resulting in improved MI/RI outcomes. These findings offer new insights into neutrophil heterogeneity and pinpoint a specific subset critical for NET formation, underscoring their potential as diagnostic biomarkers and therapeutic targets for MI/RI management.}, archive = {J_ADVS}, author = {Shiyu Hu and Feng Zhang and Jingpu Wang and Jian Zhang and Chenguang Li and Yang Lyu and Yiwen Wang and Rong Huang and Yang Gao and Hongbo Yang and Juying Qian and Wenwen Tang and Jiatian Cao and Junbo Ge}, doi = {10.1002/advs.202415205}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415205}, shortjournal = {Adv. Sci.}, title = {MMP9High neutrophils are critical mediators of neutrophil extracellular traps formation and myocardial Ischemia/Reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). In situ control of reactive mesogens alignment during 3D printing by two-photon lithography. ADVS, 12(21), 2415159. (www)

  @article{ , abstract = {Photopolymerizable liquid crystals, also known as reactive mesogens, are leading candidates for additive manufacturing of smart microdevices via two-photon lithography (TPL). While substantial advancements are made toward innovative applications, precise control of molecular alignment during fabrication, essential for tailoring complex optical and mechanical responses, remains a significant challenge. Current solutions require elaborate multi-step procedures or customized setups to achieve 2D or 3D alignment patterns. Herein, the deterministic effect of TPL on the orientation of mesogenic moieties is reported, under optimized printing conditions. Specifically, a single-step simple method is developed for aligning the nematic director in situ, with sub-diffraction-limited resolution, during 3D printing. Based on the conventional TPL workflow, the “director-tuning mode” (DiTuM) relies on the anisotropic photopolymerization reaction occurring along the print path at low laser scan speeds (≈0.1mm s −1 ). A TPL-induced “easy axis” arises for the mesogenic moieties, programmable in direction and strength, and competes with the initial alignment to create potentially convolute 3D director fields. The method holds considerable promise for 3D/4D printing, enabling advanced functionalities, and offers a robust platform for anti-counterfeiting applications, leveraging the unique optical signatures generated by complex microstructures.}, archive = {J_ADVS}, author = {Tiziana Ritacco and Alfredo Mazzulla and Michele Giocondo and Gabriella Cipparrone and Pasquale Pagliusi}, doi = {10.1002/advs.202415159}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415159}, shortjournal = {Adv. Sci.}, title = {In situ control of reactive mesogens alignment during 3D printing by two-photon lithography}, volume = {12}, year = {2025}, }
• (2025). Novel gas sensor signal acquisition method: Amplifying sensor signals and enabling efficient gas identification. ADVS, 12(21), 2415104. (www)

  @article{ , abstract = {Enhancing sensor sensitivity and gas identification capabilities is essential for the broad application of gas sensors. Developing efficient transducing methods for sensors can be applied to a wide range of sensors. However, developing such methods for resistive sensors remains challenging. In this study, an operating method that enhances both sensitivity and gas identification capability in resistive gas sensors is presented. The sensor operation is divided into two phases: the reaction phase and the signal detection phase, and propose optimized operating methods for each. In the reaction phase, the chemisorption of oxidizing and reducing gases are maximized through appropriate operating methods for each. In the signal detection phase, a read-bias technique is introduced, enhancing sensitivity across all gases, with a 23-fold increase for 500 ppb NO 2 and a sixfold increase for 50 ppm H 2 S. Additionally, the limit of detection (LOD) can be improved, with the NO 2 LOD reduced from 11.8 to 1.4 ppb. Furthermore, a method for obtaining gas-specific signal patterns is presented that reflect the unique diffusion properties of each gas by simply adjusting the signal readout conditions. This approach demonstrates the accurate identification of four different gases using only a single sensor.}, archive = {J_ADVS}, author = {Kangwook Choi and Ryun-Han Koo and Jinwoo Park and Donghee Kim and Jaehyeon Kim and Hunhee Shin and Gyuweon Jung and Jong-Ho Lee}, doi = {10.1002/advs.202415104}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2415104}, shortjournal = {Adv. Sci.}, title = {Novel gas sensor signal acquisition method: Amplifying sensor signals and enabling efficient gas identification}, volume = {12}, year = {2025}, }
• (2025). Identification of tumor-specific surface proteins enables quantification of extracellular vesicle subtypes for early detection of pancreatic ductal adenocarcinoma. ADVS, 12(21), 2414982. (www)

  @article{ , abstract = {Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality, largely due to late-stage diagnosis. Reliable early detection methods are critically needed. PDAC-derived extracellular vesicles (EVs) carry molecules that reflect their parental tumor cells and are detectable in early disease stages, offering a promising noninvasive diagnostic approach. Here, a streamlined PDAC EV Surface Protein Assay for quantifying PDAC EV subpopulations in 300-µL plasma through a two-step workflow is presented: i) click chemistry-mediated EV enrichment using EV Click Beads and trans-cyclooctene-grafted antibodies targeting three PDAC EV-specific surface proteins (MUC1, EGFR, and TROP2), and ii) quantification of enriched PDAC EVs through reverse transcription-quantitative polymerase chain reaction. The three PDAC EV-specific surface proteins are identified using a bioinformatics framework and validated on PDAC cell lines and tissue microarrays. The resultant PDAC EV Score, derived from signals of the three PDAC EV subpopulations, demonstrates robust differentiation of PDAC patients from noncancer controls, with area under the receiver operating characteristic curves of 0.94 in the training ( n = 124) and 0.93 in the validation ( n = 136) cohorts. This EV-based diagnostic approach successfully exploits PDAC EV subpopulations as novel biomarkers for PDAC early detection, translating PDAC surface proteins into an EV-based liquid biopsy platform.}, archive = {J_ADVS}, author = {Chen Zhao and Zhili Wang and Hyoyong Kim and Hui Kong and Junseok Lee and Jacqueline Ziqian Yang and Anmin Wang and Ryan Y. Zhang and Yong Ju and Jina Kim and Bing Feng and Dejun Liu and Yating Zhang and Zhenfang Wang and Yandong Zhang and Shujing Guo and Dekang Gao and James S. Tomlinson and Renjun Pei and Jipeng Wan and Stephen J. Pandol and Myung-Shin Sim and Sungyong You and Ding Ma and Shaohua Lu and Na Sun and Hsian-Rong Tseng and Yazhen Zhu}, doi = {10.1002/advs.202414982}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414982}, shortjournal = {Adv. Sci.}, title = {Identification of tumor-specific surface proteins enables quantification of extracellular vesicle subtypes for early detection of pancreatic ductal adenocarcinoma}, volume = {12}, year = {2025}, }
• (2025). A versatile high-throughput single-cell screening platform for profiling antigen-specific long-lived b cells in blood and bone marrow. ADVS, 12(21), 2414945. (www)

  @article{ , abstract = {Antigen-specific B cells play a crucial role in the long-term immune response following infection or vaccination, differentiating into antibody-secreting cells (ASCs) and memory B cells (MBCs). However, profiling ASCs is challenging primarily due to their lack of membrane-bound surface B cell receptors. In this study, the Modular Superhydrophobic Microwell Array Chip (MoSMAR-chip) is introduced as a versatile, cost-effective, and high-throughput platform for identifying and characterizing individual antigen-specific ASCs and MBCs at the single-cell level within seven days. Using this platform, comprehensive analyses of single ASCs could be performed from bone marrows of coronavirus disease 2019 (COVID-19) vaccine-immunized mice and a diverse set of antibodies capable of neutralizing the highly divergent JN1 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were identified. These results demonstrate that the MoSMAR-chip facilitates efficient single-cell multi-omics and functional analyses of antigen-specific ASCs, offering a powerful tool for investigating complex long-term B cell immunity in diverse clinical conditions, such as infectious diseases, autoimmunity, and beyond.}, archive = {J_ADVS}, author = {Tian Zhao and Yuqing Lei and Chang Liu and Dong Zhang and Kaiyi Li and Sisi Shan and Chenyu Li and Zimeng Wei and Yuhan Yang and Ting Zhang and Kai Sun and Haoran Sun and Linqi Zhang and Peng Liu}, doi = {10.1002/advs.202414945}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414945}, shortjournal = {Adv. Sci.}, title = {A versatile high-throughput single-cell screening platform for profiling antigen-specific long-lived b cells in blood and bone marrow}, volume = {12}, year = {2025}, }
• (2025). Deep learning-enhanced hand-driven microfluidic chip for multiplexed nucleic acid detection based on RPA/CRISPR. ADVS, 12(21), 2414918. (www)

  @article{ , abstract = {The early detection of high-risk human papillomavirus (HR-HPV) is crucial for the assessment and improvement of prognosis in cervical cancer. However, existing PCR-based screening methods suffer from inadequate accessibility, which dampens the enthusiasm for screening among grassroots populations, especially in resource-limited areas, and contributes to the persistently high mortality rate of cervical cancer. Here, a portable system is proposed for multiplexed nucleic acid detection, termed R-CHIP , that integrates R ecombinase polymerase amplification (RPA), C RISPR detection, H and-driven microfluidics, and an artificial I ntelligence P latform. The system can go from sample pre-processing to results readout in less than an hour with simple manual operation. Optimized for sensitivity of 10 −17 M for HPV-16 and 10 −18 M for HPV-18, R-CHIP has an accuracy of over 95% in 300 tests on clinical samples. In addition, a smartphone microimaging system combined with the ResNet-18 deep learning model is used to improve the readout efficiency and convenience of the detection system, with initial prediction accuracies of 96.0% and 98.0% for HPV-16 and HPV-18, respectively. R-CHIP, as a user-friendly and intelligent detection platform, has great potential for community-level HR-HPV screening in resource-constrained settings, and contributes to the prevention and early diagnosis of other diseases.}, archive = {J_ADVS}, author = {Tao Xu and Ying Zhang and Shunji Li and Chenxi Dai and Hongguo Wei and Dongjuan Chen and Yunjun Zhao and He Liu and Deliang Li and Peng Chen and Bi-Feng Liu and Ye Tian}, doi = {10.1002/advs.202414918}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414918}, shortjournal = {Adv. Sci.}, title = {Deep learning-enhanced hand-driven microfluidic chip for multiplexed nucleic acid detection based on RPA/CRISPR}, volume = {12}, year = {2025}, }
• (2025). A hollow shell-lattice soft robot in flexible pipelines with flowing fluids. ADVS, 12(21), 2414882. (www)

  @article{ , abstract = {Pipeline-crawling soft robots are increasingly preferable for effective inspection and maintenance of flexible pipes. However, most existing robots occupy the pipe cross-sections, disrupting the normal operation of the working systems. In this study, an innovative shell-lattice soft robot is designed for crawling in pipes with fluid flows. The robot features a hollow body with a pneumatic actuator in the middle and two lattice shells at the head and tail parts. It enables earthworm-like locomotion through the implementation of opposite radial deformations in the two lattice shells. The hollow body architecture ensures unimpeded fluid flow during its crawling, even when mixed with solid impurities. Moreover, the surface-to-surface contact of the robot with the pipeline walls confers superior load-carrying capability, facilitating the transport of devices necessary for inspection and maintenance tasks. The robot is also capable of traversing various pipes with different frictional coefficients, irregular cross-sectional shapes, and varying curvatures, and can support untethered operation. Finally, potential applications of this robot in obstructed concealed pipes and disturbed offshore pipes are demonstrated. By leveraging advanced fabrication techniques, smart materials, and propulsion methods, it is anticipated that the designed robot may show significant scalability and applicability across diverse domains, including healthcare, aviation, and gas-and-oil transportation.}, archive = {J_ADVS}, author = {Di Guo and Yiqiang Wang and Zhan Kang}, doi = {10.1002/advs.202414882}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414882}, shortjournal = {Adv. Sci.}, title = {A hollow shell-lattice soft robot in flexible pipelines with flowing fluids}, volume = {12}, year = {2025}, }
• (2025). Neuronal C/EBPβ shortens the lifespan via inactivating NAMPT. ADVS, 12(21), 2414871. (www)

  @article{ , abstract = {The brain plays a central role in aging and longevity in diverse model organisms. Morphological and functional alteration in the aging brain elicits age-associated neuronal dysfunctions. However, the primary mechanism deteriorating the brain functions to regulate the aging process remains incompletely understood. Here, it is shown that neuronal CCAAT/enhancer binding protein β (C/EBPβ) escalation during aging dictates the frailty and lifespan via inactivating nicotinamide phosphoribosyltransferase (NAMPT). Upregulated C/EBPβ drives neuronal senescence and neuronal loss, associated with NAMPT fragmentation by active asparagine endopeptidase (AEP), leading to nicotinamide adenine dinucleotide (NAD + ) depletion. Knockout of AEP or expression of AEP-resistant NAMPT N136A mutant significantly elongates the lifespan of neuronal-specific Thy 1-C/EBPβ transgenic mice. Overexpression of the C. elegans C/EBPβ ortholog cebp-2 in neurons shortens lifespan and decreases NAD + levels, which are restored by feeding nicotinamide mononucleotide (NMN) or AEP inhibitor #11a. Feeding NMN or #11a substantially ameliorates the cognitive and motor impairments of Thy 1-C/EBPβ mice and increases the life expectancy. Notably, #11a demonstrates a better therapeutic effect than NMN in improving aging phenotype in Thy 1-C/EBPβ transgenic mice, which show accelerated aging features. Hence, blockade of AEP via therapeutic intervention may provide an unprecedented strategy for fighting aging and various age-associated diseases.}, archive = {J_ADVS}, author = {Bowei Li and Zhongyun Xie and Mengmeng Wang and Shuke Nie and Zhengjiang Qian and Xin Meng and Xia Liu and Seong Su Kang and Keqiang Ye}, doi = {10.1002/advs.202414871}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414871}, shortjournal = {Adv. Sci.}, title = {Neuronal C/EBPβ shortens the lifespan via inactivating NAMPT}, volume = {12}, year = {2025}, }
• (2025). Inhibiting the histone demethylase kdm4a restrains cardiac fibrosis after myocardial infarction by promoting autophagy in premature senescent fibroblasts. ADVS, 12(21), 2414830. (www)

  @article{ , abstract = {Premature senescent fibroblasts (PSFs) play an important role in regulating the fibrotic process after myocardial infarction (MI), but their effect on cardiac fibrosis remains unknown. Here, the investigation is aimed to determine whether PSFs contribute to cardiac fibrosis and the underlying mechanisms involved. It is observed that premature senescence of fibroblasts is strongly activated in the injured myocardium at 7 days after MI and identified that Kdm4a is located in PSFs by the analysis of scRNA-seq data and immunostaining staining. Moreover, fibroblast specific gain- and loss-of-function assays showed that Kdm4a promoted the premature senescence of fibroblasts and cardiac interstitial fibrosis, contributing to cardiac remodeling in the advanced stage after MI, without influencing early cardiac rupture. ChIP-seq and ChIP-PCR revealed that Kdm4a deficiency promoted autophagy in PSFs by reducing Trim44 expression through increased levels of the H3K9me3 modification in the Trim44 promoter region. Furthermore, a coculture system revealed that Kdm4a overexpression increased the accumulation of PSFs and the secretion of senescence-associated secretory phenotype (SASP) factors, subsequently inducing cardiac fibrosis, which could be reversed by Trim44 interference. Kdm4a induces the premature senescence of fibroblasts through Trim44-mediated autophagy and then facilitates interstitial fibrosis after MI, ultimately resulting in cardiac remodeling, but not affecting ventricular rupture.}, archive = {J_ADVS}, author = {Ming Jin and Chuling Li and Zhaoyi Wu and Zhenquan Tang and Jingfang Xie and Guoquan Wei and Zhiwen Yang and Senlin Huang and Yijin Chen and Xinzhong Li and Yanmei Chen and Wangjun Liao and Yulin Liao and Guojun Chen and Hao Zheng and Jianping Bin}, doi = {10.1002/advs.202414830}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414830}, shortjournal = {Adv. Sci.}, title = {Inhibiting the histone demethylase kdm4a restrains cardiac fibrosis after myocardial infarction by promoting autophagy in premature senescent fibroblasts}, volume = {12}, year = {2025}, }
• (2025). Development of carbon-11 labeled pyrimidine derivatives as novel positron emission tomography (PET) agents enabling brain sigma-1 receptor imaging. ADVS, 12(21), 2414827. (www)

  @article{ , abstract = {The sigma-1 receptor (σ1R) is a stress-activated chaperone protein that has emerged as a significant therapeutic target for neurodegenerative disorders. Developing effective positron emission tomography (PET) imaging probes targeting σ1R is crucial for visualizing its distribution and function in the brain, as well as facilitating related drug development. In this study, two novel 11 C-labeled PET probes based on the structure of a potent σ1R ligand Lan-0101 are designed and synthesized. PET imaging studies in mice reveal that [ 11 C]CNY-01 exhibits good brain uptake and binding specificity. Subsequent evaluation in non-human primates further demonstrates that [ 11 C]CNY-01 displays favorable brain penetration, slow clearance kinetics, and characteristics of irreversible binding to its target in blockage experiments. To assess the clinical potential of the probe, both in vitro experiments and in vivo PET imaging using [ 11 C]CNY-01 are conducted in Alzheimer's disease (AD) transgenic mouse models. These studies reveal a significant decrease in σ1R expression in the brain under conditions of AD amyloid pathology and microglial activation, highlighting the probe's sensitivity to disease-related receptor changes. This work establishes [ 11 C]CNY-01 as a promising tool for investigating the relationship between σ1R and neurological disorders, potentially advancing the understanding of σ1R's role in disease pathophysiology and therapeutic interventions.}, archive = {J_ADVS}, author = {Ping Bai and Ashley Gomm and Chi-Hyeon Yoo and Prasenjit Mondal and Fleur Marie Lobo and Hui Meng and Yanting Zhou and Weiyao Xie and Hsiao-Ying Wey and Rudolph E. Tanzi and Can Zhang and Changning Wang and Yu Lan}, doi = {10.1002/advs.202414827}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414827}, shortjournal = {Adv. Sci.}, title = {Development of carbon-11 labeled pyrimidine derivatives as novel positron emission tomography (PET) agents enabling brain sigma-1 receptor imaging}, volume = {12}, year = {2025}, }
• (2025). Dimethyl itaconate alleviates escherichia coli-induced endometritis through the guanosine-CXCL14 axis via increasing the abundance of norank_f_Muribaculaceae. ADVS, 12(21), 2414792. (www)

  @article{ , abstract = {Endometritis, a prevalent reproductive system disease with high incidence, leads to reproductive dysfunction in humans and animals, causing huge economic losses. Dimethyl itaconate (DI) has been demonstrated to exert protective effects in multiple inflammatory diseases. Nevertheless, the efficacy of DI in preventing endometritis and the role played by the gut microbiota remain unknown. In this study, it is found that DI ameliorated Escherichia coli ( E. coli) induced endometritis in mice. The protective effect is abolished by antibiotic-induced depletion of the gut microbiota, and fecal microbiota transplantation (FMT) from DI-treated mice to recipient mice ameliorated E. coli -induced endometritis. Integrative multiomics reveals that DI promotes the multiplication of norank_f_Muribaculaceae in vivo, and supplementation of Muribaculum intestinale (DSM 28989), which belongs to the norank_f_Muribaculaceae genus, upregulates the level of guanosine in the uterus. Mechanistically, the protective effect of guanosine in endometritis is mediated by activating the expression of CXCL14 in uterine epithelial cells. Moreover, the antibody-neutralizing experiment of CXCL14 eliminated this protective effect. In conclusion, this study elucidates the significant role of the gut microbiota and its metabolites in the protection of DI against endometritis, and provides new evidence for the regulation of distal organ by the gut microbiota.}, archive = {J_ADVS}, author = {Yuhang He and Jiapei Cai and Xufeng Xie and Xinyu Zhang and Linkai Qu and Jiuxi Liu and Yongguo Cao}, doi = {10.1002/advs.202414792}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414792}, shortjournal = {Adv. Sci.}, title = {Dimethyl itaconate alleviates escherichia coli-induced endometritis through the guanosine-CXCL14 axis via increasing the abundance of norank_f_Muribaculaceae}, volume = {12}, year = {2025}, }
• (2025). Nuclear translocation of S100A9 triggers senescence of human amnion fibroblasts by de-repressing LINE1 via heterochromatin erosion at parturition. ADVS, 12(21), 2414682. (www)

  @article{ , abstract = {Aging of the fetal membranes participates in labor onset. However, the underlying mechanism is poorly understood. Here, we identify that the classical secretory protein S100 calcium-binding protein A9 (S100A9), upon de-phosphorylation at Thr 113, translocates to the nuclei of amnion fibroblasts of the human fetal membranes, where S100A9 causes heterochromatin erosion via segregation of heterochromatin maintenance proteins, resulting in Long Interspersed Nuclear Element-1 (LINE1) de-repression at parturition. Increased LINE1 retrotransposition further activates the type I interferon response via the cGAS-STING pathway, thereby leading to amnion fibroblast senescence with consequent increased secretion of components associated with senescence-associated secretory phenotype. Mouse studies show that intra-amniotic injection of vector specifically expressing S100A9 in the nucleus induces preterm birth along with LINE1 de-repression and increased cellular senescence in the fetal membranes, which is blocked by inhibition of LINE1 reverse-transcription. Together, these findings highlight that nuclear-translocated S100A9 acts as a heterochromatin disruptor to de-repress LINE1 which subsequently triggers amnion fibroblast senescence at parturition.}, archive = {J_ADVS}, author = {Fan Zhang and Meng-Die Li and Fan Pan and Wen-Jia Lei and Yang Xi and Li-Jun Ling and Leslie Myatt and Kang Sun and Wang-Sheng Wang}, doi = {10.1002/advs.202414682}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414682}, shortjournal = {Adv. Sci.}, title = {Nuclear translocation of S100A9 triggers senescence of human amnion fibroblasts by de-repressing LINE1 via heterochromatin erosion at parturition}, volume = {12}, year = {2025}, }
• (2025). TRIM25-mediated INSIG1 ubiquitination promotes MASH progression through reprogramming lipid metabolism. ADVS, 12(21), 2414646. (www)

  @article{ , abstract = {The global incidence of Metabolic dysfunction-associated steatohepatitis (MASH) is increasing, highlighting the urgent need for new treatment strategies. This study aimed to investigate the involvement of tripartite motif-containing 25 (TRIM25) in MASH progression and explore the therapeutic potential of the TRIM25 inhibitor, C 27 H 26 N 2 O 4 S. Functional studies reveal that TRIM25 promoted lipid accumulation and inflammation by ubiquitinating and degrading insulin-induced gene 1 (INSIG1), thereby enhancing the nuclear translocation of sterol regulatory element-binding protein 2 (SREBP2) and upregulating lipid biosynthesis genes. In vivo experiments using TRIM25 knockout mice demonstrated that TRIM25 deletion ameliorated MASH progression, reduced fibrosis, and decreased inflammatory cell infiltration. It identifies C 27 H 26 N 2 O 4 S as a specific inhibitor of TRIM25. C 27 H 26 N 2 O 4 S effectively decreased INSIG1 ubiquitination and attenuated lipid accumulation in the hepatocytes. To enhance the hepatic delivery of C 27 H 26 N 2 O 4 S, it utilizes exosomes derived from hepatic stellate cells (HSC-EVs). Biodistribution analysis confirmed that the HSC-EVs preferentially accumulated in the liver. In a MASH mouse model, HSC-EV-encapsulated C 27 H 26 N 2 O 4 S (C 27 H 26 N 2 O 4 S@HSC-EV) significantly reduced hepatic lipid accumulation and alleviated MASH severity and fibrosis. This study highlights the critical regulatory role of TRIM25 in MASH and presents C 27 H 26 N 2 O 4 S@HSC-EV as a promising therapeutic approach for MASH treatment.}, archive = {J_ADVS}, author = {Hao Zhang and Xiangxu Kong and Wei Wang and Huaxin Zhou and Haoran Qu and Zhengyao Guan and Honglei Wu and Xiangyu Zhai and Bin Jin}, doi = {10.1002/advs.202414646}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414646}, shortjournal = {Adv. Sci.}, title = {TRIM25-mediated INSIG1 ubiquitination promotes MASH progression through reprogramming lipid metabolism}, volume = {12}, year = {2025}, }
• (2025). Tunable high-performance photo-assisted Li–O2 batteries by the construction of ferroelectric photocathode. ADVS, 12(21), 2414616. (www)

  @article{ , abstract = {Photo-assistance is considered to be an effective approach to reducing the overpotential for lithium-oxygen (Li–O 2 ) batteries. However, the advancement is greatly hindered by the rapidly recombined photoexcited electrons and holes upon the discharging and charging processes. Herein, a breakthrough in overcoming these challenges is achieved by developing an efficient ferroelectric photocatalyst with spontaneous polarization-induced internal electric fields. Tungsten (W) doped Bi 3 TiNbO 9 (Bi 3 TiNbO 9 -W) as a photocatalyst exhibits enhanced anisotropic migration of photogenerated electrons and holes, which play a key role in reducing the overpotential in the discharge and charge processes, enabling the desirable spatial separation of carriers. Benefiting from the driving force for charge separation, the photocatalytic oxygen reduction and evolution reaction activity is largely improved. As a result, the Bi 3 TiNbO 9 -W-based Li–O 2 batteries have shown incremental round-trip efficiencies of 95.9% based on the ultra-high discharge voltage (3.25 V) and ultra-low charge voltage (3.39 V). Besides, the constructed photo-assisted Li–O 2 batteries deliver a high rate capability and ultralong durability within 960 h. These findings demonstrate the crucial role of ferroelectric polarization in the improved photocatalytic reaction process, providing significant insight into addressing the overpotential bottleneck in Li–O 2 batteries.}, archive = {J_ADVS}, author = {Huan-Feng Wang and Yu-Fei Wang and De-Hui Guan and Xiao-Xue Wang and Xin-Yue Ma and Xin-Yuan Yuan and Ji-Jing Xu}, doi = {10.1002/advs.202414616}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414616}, shortjournal = {Adv. Sci.}, title = {Tunable high-performance photo-assisted Li–O2 batteries by the construction of ferroelectric photocathode}, volume = {12}, year = {2025}, }
• (2025). Surface engineering enabled capacitive gas-phase water molecule sensors in carbon nanodots. ADVS, 12(21), 2414611. (www)

  @article{ , abstract = {Gas-phase water molecule sensors are essential in scientific, industrial, and environmental applications, playing a crucial role in ensuring human safety, monitoring pollution, and optimizing processes. However, developing gas-phase water sensors with high sensitivity remains a significant challenge. Herein, the effect of molecular adsorption on capacitive response is explored, and a facile surface engineering strategy to achieve sensitive carbon nanodots (CDs)-based sensors for H 2 O is demonstrated.hydrophilic raw precursor is utilized to prepare the hydrophilic CDs and further employ these CDs as active media in the capacitive sensors, demonstrating how surface adsorption influences the capacitive response to H 2 O molecules. By applying surface engineering, the molecular affinity potential of CDs is regulated, resulting in sensors that exhibit a broad detection range from 11% to 98% relative humidity (RH), with a remarkable sensitivity of 3.3 × 10 5 pF/RH and an impressive response of 1.8 × 10 8 % at 98% RH. These CDs-based sensors present great potential for applications in respiratory monitoring, information exchange, contactless recognition of finger trajectories, etc. The findings unveil the unique influence of molecular affinity on capacitive response, opening new avenues for the design and applications of highly sensitive molecular sensors.}, archive = {J_ADVS}, author = {Jin-Xu Qin and Cheng-Long Shen and Wu-You Zhang and Yuan Deng and Shou-Long Lai and Chao-Fan Lv and Hang Liu and Ying-Jie Zhang and Lan Liu and Lei Li and Xi-Gui Yang and Chong-Xin Shan}, doi = {10.1002/advs.202414611}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414611}, shortjournal = {Adv. Sci.}, title = {Surface engineering enabled capacitive gas-phase water molecule sensors in carbon nanodots}, volume = {12}, year = {2025}, }
• (2025). Graphene nanofibers by integrated manufacturing of electrospinning and laser graphitization for miniaturized energy storage devices. ADVS, 12(21), 2414607. (www)

  @article{ , abstract = {Carbon nanofibers (CNFs) are emerging as promising materials for miniaturized energy storage devices (MESDs) due to their high specific surface area, excellent electrochemical performance, low internal resistance, and durability. Their versatility and tunability make them ideal candidates for various applications, making CNFs a key player in advancing compact and efficient energy storage solutions. Nonetheless, CNFs necessitate an extra step involving either physical or chemical treatments to regulate their morphology, augment surface area, and create micropatterns suitable for MESDs. Here, innovations in material fabrication using an integrated manufacturing process are reported that combines electrospinning and laser-induced graphitization to create graphene nanofibers (GNFs) from fluorinated polyimide nanofibers (fPI NFs). Initially, electrospinning yields uniformly sized and shaped fluorinated poly(amic) acid nanofibers, which are subsequently thermally imidized to form fPI NFs. Laser photothermal treatment of fPI NFs generates hierarchical meso- and nanopores in GNFs, enhancing specific surface area and electrochemical properties, including specific capacitance, cyclic stability, rate capability, areal capacitance, power density, and energy density. This integrated approach synergistically fabricates GNFs for MESD applications, particularly GNF-based micro-supercapacitors (MSCs), demonstrating a remarkable areal capacitance and an aerial energy density two orders of magnitude higher than MSCs based on laser-induced graphene derived from conventional polyimide film.}, archive = {J_ADVS}, author = {Bumjun Park and Shirin Movaghgharnezhad and Seung Min Lee and Yonghyeon Park and Sejin Son and Yun Suk Huh and Pilgyu Kang}, doi = {10.1002/advs.202414607}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414607}, shortjournal = {Adv. Sci.}, title = {Graphene nanofibers by integrated manufacturing of electrospinning and laser graphitization for miniaturized energy storage devices}, volume = {12}, year = {2025}, }
• (2025). Protease-mediated synthesis of zein nanofibrils: From structural elucidation to functional application. ADVS, 12(21), 2414606. (www)

  @article{ , abstract = {The fibrillization of plant-based proteins enhances their functionality, enabling potential applications in food and sustainable materials. Zein, a highly hydrophobic protein from corn, is a versatile industrial ingredient, but its functionality is limited to environments containing high levels of organic solvents. This study aims to develop a protease-assisted approach for synthesizing zein nanofibrils as functional building blocks, eliminating the need for organic solvents in the conventional process. Through proteomics, microscopy, and spectroscopy, the bioprocess and structural features of these novel nanofibrils are characterized. The results reveal that over 50% of α-zein sequence is prone to fibrillization, with pepsin demonstrating a clear advantage in efficiently releasing fibrillization-prone peptide segments (bioconversion > 70%) and producing a peptide mixture suitable for self-assembly. The fibrillization process is significantly enhanced by increasing peptide concentration and adding the anionic surfactant sodium dodecyl sulfate, which can lead to the formation of semiflexible fibrils with amyloid-like β-sheet structures. These nanofibrils outperformed native zein as emulsifiers in high internal phase emulsions and are able to form fibrous hydrogels. The protease-assisted fibrillization process achieved in this study provides an effective solution for expanding applications of zein or corn proteins in a purely aqueous environment.}, archive = {J_ADVS}, author = {Mingqin Li and Tonghui Jin and Simone Wüthrich and Jiangtao Zhou and Qiyao Sun and Ting Li and Zhou Dong and Eva Maria Zunzuneigui Bru and Raffaele Mezzenga}, doi = {10.1002/advs.202414606}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414606}, shortjournal = {Adv. Sci.}, title = {Protease-mediated synthesis of zein nanofibrils: From structural elucidation to functional application}, volume = {12}, year = {2025}, }
• (2025). A porphyrin nanomaterial for photoimmunotherapy for treatment of melanoma. ADVS, 12(21), 2414592. (www)

  @article{ , abstract = {The incidence of melanoma, the third most common skin cancer, has been on the rise in recent years. In addition, it has a high mortality rate due to its high aggressiveness. Phototherapy, as a promising treatment method, can effectively kill tumor cells, but it is incapable of the treatment of tumor metastasis. Herein, a nanomaterial (TPC@OVA NPs) is developed for phototherapy in conjunction with immunotherapy against melanoma. TPC, as a derivative of porphyrin, is used as a photosensitizer with excellent biosafety and photostability. After assembly with ovalbumin (OVA), TPC@OVA NPs with vaccine properties is formed, which can not only ablate the primary tumor but also induce immunogenic cell death (ICD). In addition, DC cells can be stimulated to mature by exogenous OVA, enhancing the immune response against tumors by further activating T lymphocytes. Combined with immune checkpoint inhibitor aPD-1, the immune microenvironment is reshaped, and the increased activity of immunotherapy are validated. This work highlights the potential of combining phototherapy and immunotherapy against metastasis.}, archive = {J_ADVS}, author = {Zhuang Fan and Qing Pei and Haojie Sun and Haiyan Zhang and Zhigang Xie and Tao Zhang and Chong Ma}, doi = {10.1002/advs.202414592}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414592}, shortjournal = {Adv. Sci.}, title = {A porphyrin nanomaterial for photoimmunotherapy for treatment of melanoma}, volume = {12}, year = {2025}, }
• (2025). Therapeutic delivery of circDYM by perillyl alcohol nanoemulsion alleviates LPS-induced depressive-like behaviors. ADVS, 12(21), 2414559. (www)

  @article{ , abstract = {RNA therapeutics have recently shown significant promise in treating a variety of diseases, including cancers, infectious diseases, and genetic disorders. However, their potential in addressing neuropsychiatric disorders has been limited by the lack of an efficient delivery system to the central nervous system (CNS). Here, a novel nanoemulsion platform, perillyl alcohol nanoemulsions (PANEs) is introduced, designed for the therapeutic delivery of circDYM to brain and alleviated depressive-like behaviors. PANEs successfully encapsulated circDYM using cationic lipid compositions, enhancing its delivery efficiency to the mouse brain via its perillyl alcohol phase. The optimized formulation, PANE2-4, significantly improved the brain delivery efficiency of circDYM compared to both free circDYM and standard lipid nanoparticle formulations. Intranasal administration of PANE2-4-circDYM effectively alleviated depressive-like behaviors in the LPS-induced mouse model of depression. This effect is achieved by reducing the CD11b + CD45 dim microglia population and iNOS expression, restoring the expression of protein-95 (PSD-95) and synaptophysin. These findings indicated that PANE represents an efficient platform for delivering circRNAs to the brain, and intranasal administration of PANE2-4-circDYM is a promising strategy for ameliorating LPS-induced depressive-like behaviors.}, archive = {J_ADVS}, author = {Feng Gao and Zhongkun Zhang and Minzi Ju and Liang Bian and Huijuan Wang and Sibo Zhao and Ningbo Cai and Yu Wang and Yanpeng Jia and Ling Shen and Yuan Zhang and Honghong Yao}, doi = {10.1002/advs.202414559}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414559}, shortjournal = {Adv. Sci.}, title = {Therapeutic delivery of circDYM by perillyl alcohol nanoemulsion alleviates LPS-induced depressive-like behaviors}, volume = {12}, year = {2025}, }
• (2025). CXCL13 damages blood spinal cord barrier by promoting RNF6/Sqstm1-ubiquitination induced autophagy in experimental allergic encephalomyelitis. ADVS, 12(21), 2414550. (www)

  @article{ , abstract = {The damage of blood spinal cord barrier (BSCB) is contributing to the disruption of immune microenvironment within central nervous system during the progression of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Nevertheless, the underlying mechanisms responsible for barrier impairment remain inadequately understood. Here, by analyzing the protein profiles in peripheral blood serum, chemokine (C-X-C motif) ligand 13 (CXCL13) was identified to be increased with the progression of MS and EAE. The absence of CXCL13 resulted in alleviation of EAE symptoms, as evidenced by a reduced clinical score, decreased barrier damage, as well as diminished demyelination and inflammatory response in the spinal cord. In the BSCB model, CXCL13 was found to impair barrier structure and function in a dose- and time-dependent manner, which was associated with exacerbated autophagy in endothelial cells, while the application of autophagy inhibitors partially mitigated this damage. Mechanistically, CXCL13 enhanced the expression of RNF6, an E3 ubiquitin-protein ligase, facilitating the conjugation to Sqstm1 for the ubiquitination at the K314 residue. These findings suggest that CXCL13 significantly contributes to the impairment of the BSCB by promoting RNF6/Sqstm1-ubiquitination-induced autophagy during the progression of EAE, thereby offering a promising diagnostic and therapeutic target for MS.}, archive = {J_ADVS}, author = {Jingjing Han and Rui Hong and Cong Cao and Wanhua Feng and Wei Zhuang and Gui Wang and Jingchao Tang and Ya Yang and Chu Zhang and Aihua Zhou and Xuebin Qu}, doi = {10.1002/advs.202414550}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414550}, shortjournal = {Adv. Sci.}, title = {CXCL13 damages blood spinal cord barrier by promoting RNF6/Sqstm1-ubiquitination induced autophagy in experimental allergic encephalomyelitis}, volume = {12}, year = {2025}, }
• (2025). Uncover hidden physical information of soft matter by observing large deformation. ADVS, 12(21), 2414526. (www)

  @article{ , abstract = {Accurate and non-destructive detection of material abnormalities inside soft matter remains an elusive challenge due to its variable and heterogeneous nature, especially regarding non-visual information. Here, a method is introduced that uncovers the physical information of internal material abnormalities from large deformations observed on the surface of the soft object. It finds the most probable values of imperceptible physical parameters by matching the nonlinear surface deformation between observation and finite element simulation through parallel Bayesian optimization, balancing the trade-off between simulation accuracy and computational efficiency. Numerical and experimental tests, including simulated cases of aortic valve calcification, are conducted to showcase the effectiveness of our method, where we successfully recover hidden physical parameters including material stiffness, abnormality shape, and location. The method holds substantial promise for advancing the fields of material perception of robots, soft robotics, biology, and medical diagnostics, offering a powerful tool for the precise, efficient, and non-invasive analysis of soft matter.}, archive = {J_ADVS}, author = {Huanyu Yang and Yitao Cheng and Penghui Zhao and Jiageng Cai and Zhaowei Yin and Shaomin Chen and Ge Guo and Chi Zhu and Ke Liu and Lingyun Zu}, doi = {10.1002/advs.202414526}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414526}, shortjournal = {Adv. Sci.}, title = {Uncover hidden physical information of soft matter by observing large deformation}, volume = {12}, year = {2025}, }
• (2025). MRAS: Master regulator analysis of alternative splicing. ADVS, 12(21), 2414493. (www)

  @article{ , abstract = {As a molecular feature that characterizes most tumor types, cancer-associated splicing dysregulation largely arises from recurrent genetic mutations and altered expression of trans -acting splicing factors. Although splicing factor mutations occur less frequently in solid tumors, splicing disorders are pervasive and proven to promote tumorigenesis. However, it still lacks an efficient way to identify the key splicing factors at the top regulatory hierarchy whose abnormal expressions induce such splicing disorders and drive phenotypic variability. Here, MRAS (Master Regulator analysis of Alternative Splicing) is introduced, a computational method designed to pinpoint the pivotal splicing factors that play a central role in shaping splicing regulatory networks and influencing cellular processes. MRAS is demonstrated its power by identifying master splicing regulators associated with various disease phenotypes, including tumor initiation, progression, metastasis, and treatment resistance. Moreover, by applying MRAS to single-cell RNA-seq data, crucial regulatory relationships that govern cell-type specific splicing programs have been uncovered. Overall, MRAS presented as an accurate and versatile approach to unraveling the underlying mechanism of splicing regulation.}, archive = {J_ADVS}, author = {Lei Zhou and Yue Huang and Yang Zhao and Dan Guo and Xiao Wen and Ruihong Xu and Xuan Lv and Song Wu and Sicheng Jing and Zhaoqi Liu}, doi = {10.1002/advs.202414493}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414493}, shortjournal = {Adv. Sci.}, title = {MRAS: Master regulator analysis of alternative splicing}, volume = {12}, year = {2025}, }
• (2025). Targeting miRNA-1a and miRNA-15b: A novel combinatorial strategy to drive adult cardiac regeneration. ADVS, 12(21), 2414455. (www)

  @article{ , abstract = {Despite its promise, cardiac regenerative therapy remains clinically elusive due to the difficulty of spatio-temporal control of proliferative induction, and the need to coordinately reprogram multiple regulatory pathways to overcome the strict post-mitotic state of human adult cardiomyocytes. To address this unmet therapeutic need, a combinatorial miRNA interference screen is performed specifically targeting cardiac-predominant miRNAs regulating key aspects of cardiomyocyte mitotic induction to cell-cycle completion in neonatal rat cardiomyocytes. In doing so combinatorial interference of miRNA-1a and miRNA-15b (LNA-1a/15b) is identified as drivers of adult cardiomyocyte proliferation. Due to miRNA-1a/15b function on multiple processes modulating adult cardiomyocyte mitosis, its inhibition augmented adult cardiomyocyte cell-cycle completion and daughter cell formation, and improved contractility in 3D human cardiac organoids, and in a mouse model of ST-segment elevation myocardial infarction. Due to the cardiac-restricted pattern of miRNA-1a/15b expression, this strategy provides a feasible means for specific cardiomyocyte proliferative induction with minimal risk of neoplasm formation and off-target toxicity. The approach further highlights an underutilized therapeutic strategy for simultaneous co-regulation of multiple disease pathways through combinatorial interference of miRNAs.}, archive = {J_ADVS}, author = {Ting Yuan and Meiqian Wu and Chaonan Zhu and Hao Yu and Minh Duc Pham and Katharina Bottermann and Yijie Mao and Yue Wang and Mathias Langner and Mirko Peitzsch and Arka Provo Das and Silke Kauferstein and Jonathan Ward and Peter Mirtschink and Andreas Michael Zeiher and Stefanie Dimmeler and Jaya Krishnan}, doi = {10.1002/advs.202414455}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414455}, shortjournal = {Adv. Sci.}, title = {Targeting miRNA-1a and miRNA-15b: A novel combinatorial strategy to drive adult cardiac regeneration}, volume = {12}, year = {2025}, }
• (2025). Assessment and mitigation of CRISPR-cas9-induced nontargeted translocations. ADVS, 12(21), 2414415. (www)

  @article{ , abstract = {The performance of CRISPR-mediated genome editing near inverted repeats (IRs) potentially results in chromosomal translocations and other catastrophic rearrangements. However, the extent of this risk may be significantly underestimated because current reporter systems focus solely on site-specific translocations. Here, trans -acting reporter systems in Escherichia coli are developed to detect nontargeted translocations. Markedly increased frequency of translocations following CRISPR-Cas9 activation is observed, with the magnitude determined primarily by the length of the IRs and the proximity between Cas9 target sites and IRs. These translocations arise through a combination of intramolecular single-strand annealing and alternative end-joining mechanisms. Furthermore, it is discovered that introducing segments homologous to IR loci can substantially mitigate nontargeted translocations without significantly compromising CRISPR-Cas9-mediated editing. The study provides valuable insights into the genetic risks associated with CRISPR technologies and suggests a viable strategy for developing genetically safer CRISPR systems.}, archive = {J_ADVS}, author = {Zhiyang Hou and Qiyi Yi and Mengying Wu and Lijun Wu and Fanghua Li and Ting Wang and Po Bian}, doi = {10.1002/advs.202414415}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414415}, shortjournal = {Adv. Sci.}, title = {Assessment and mitigation of CRISPR-cas9-induced nontargeted translocations}, volume = {12}, year = {2025}, }
• (2025). 3D-printed biomimetic vascular scaffold crosslinked with heparan sulfate for sustained release of PDGFB-LG4 fusion protein promotes bone regeneration. ADVS, 12(21), 2414362. (www)

  @article{ , abstract = {A central focus of bone tissue engineering is the construction of vascular systems, which provide nutrients for cell survival, remove metabolic waste, and accelerate tissue regeneration. Platelet-derived growth factor-BB (PDGFB) has the ability to stimulate both vascularization and bone regeneration; however, its clinical application has been hindered by side effects and low efficacy due to suboptimal delivery systems. In this study, a biomimetic vascular scaffold crosslinked with heparan sulfate (HS) is developed to enable sustained delivery of the PDGFB-LG4 fusion protein, targeting the regeneration of critically sized bone defects. The scaffold is designed with a vascular-like hierarchical structure, incorporating a customized 3D framework, multibranched microchannels, and permeable porous walls, which facilitates mass exchange and cell infiltration. PDGFB-LG4 exhibits superior osteoinductive and angiogenic activity compared to PDGFB. In a calvarial defect model, the composite scaffold (PCLHS-PDGFB-LG4) significantly enhances both vascularization and bone regeneration, demonstrating improved efficacy at lower doses compared to PDGFB. This approach may be applicable to other growth factors and gelatin-based materials, offering the potential for a wide range of applications in regenerative medicine.}, archive = {J_ADVS}, author = {Jiahua Duan and Gaofei Qian and Huikang Zhang and Feifan Wang and Qiang Tian and Dong Lei and Jianning Zhao}, doi = {10.1002/advs.202414362}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414362}, shortjournal = {Adv. Sci.}, title = {3D-printed biomimetic vascular scaffold crosslinked with heparan sulfate for sustained release of PDGFB-LG4 fusion protein promotes bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Topology-optimized bound states in the continuum with high-Q acoustic field enhancement. ADVS, 12(21), 2414344. (www)

  @article{ , abstract = {Achieving high-quality (high-Q) acoustic resonances remains a critical goal in acoustic device design, given their exceptional sound manipulation capabilities. However, enhancing Q-factors is often hindered by energy dissipation and material losses, except for leveraging bound states in the continuum (BICs). This paper introduces a methodology utilizing topology optimization to achieve high-Q resonances based on the concept of BICs, which effectively confine acoustic waves by minimizing energy leakage. This method explores entirely new topology classes through the optimization of a single unit cell embedded within periodic arrays. By engineering quasi-BIC modes and experimentally validating sharp pressure field enhancements, a robust technique that enables precise tuning of resonance frequencies and improves resilience against external perturbations, which is challenging for the conventional parameter-tuning approach is presented. These findings show promise for advancing wave-confining applications, such as energy harvesting and acoustic filtering, while pushing the performance boundaries of acoustic devices.}, archive = {J_ADVS}, author = {Weibai Li and Kazem Ghabraie and Xiaodong Huang}, doi = {10.1002/advs.202414344}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414344}, shortjournal = {Adv. Sci.}, title = {Topology-optimized bound states in the continuum with high-Q acoustic field enhancement}, volume = {12}, year = {2025}, }
• (2025). Polarized color filters using colloidal quantum rod nanocrystals for advanced high-performance displays. ADVS, 12(21), 2414316. (www)

  @article{ , abstract = {In this article, color filters (CFs) emitting linearly polarized light, achieving both full-color and pixel-level precision, which can simultaneously offer high color saturation, high ambient contrast ratio (ACR), and high efficiency for modern displays, are disclosed. The quantum rods (QRs) exhibit a narrow-band polarized emission that effectively mitigates traditional challenges of color purity and light losses. Specially designed ligands on the QR surfaces allow higher load of the QR material into the polymer matrix with uniform alignment. Optimizing inkjet printing, photolithography, and photoalignment processes, a remarkable degree of polarization (DOP) of 0.65 is achieved for precisely patterned red and green QR CFs. Due to the polarized emission of unidirectionally aligned QRs, the liquid crystal display (LCD) equipped with the designed QRCF shows enhanced efficiency and ACR, highlighting advantages for their application in next-generation displays over other types of photoluminescence CFs.}, archive = {J_ADVS}, author = {Jianxin Song and Maksym F. Prodanov and Yiyang Gao and Chengbin Kang and Debjyoti Bhadra and Yuechu Cheng and Zebing Liao and Kumar Mallem and Vigneshwaran Swaminathan and Valerii V. Vashchenko and Xiao Wu and Xinhui Lu and Abhishek K. Srivastava}, doi = {10.1002/advs.202414316}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414316}, shortjournal = {Adv. Sci.}, title = {Polarized color filters using colloidal quantum rod nanocrystals for advanced high-performance displays}, volume = {12}, year = {2025}, }
• (2025). Direct-ink-writing printed stretchable eutectic Gallium–Indium antenna for robust wireless communication. ADVS, 12(21), 2414285. (www)

  @article{ , abstract = {Stretchable antennas represent a pivotal innovation in enhancing wireless interconnection and driving the proliferation of Internet of Things (IoT) applications. Eutectic Gallium–Indium (EGaIn) is an ideal conductor for stretchable antennas. However, the inherent high surface tension and fluidity of EGaIn make the patterning low-precision, time-consuming, and failure-prone. Here a wideband stretchable antenna is presented by direct writing of thermoplastic polyurethane-modified EGaIn ink and activated by water-bath ultrasound. The ink exhibits printing-friendly rheological properties and surface energy, enabling high patterning-precision printing (10 µm) while preserving excellent conductivity (1.6 × 10 6 S m −1 ). Benefiting from these improvements, the printed antenna achieves a large fractional bandwidth (75%), a high radiation efficiency (76.6%), and an exceptional ultimate strain (> 240%). For a proof-of-concept demonstration, the antenna enables a 50-meter wireless communication, under the case of 240% stretching or conformally wrapped around a drone. This work provides an efficient and universal strategy for manufacturing stretchable antennas, with broad potential in advanced IoTs technologies.}, archive = {J_ADVS}, author = {Xiangyu Guo and Yufei Liu and Zhizhou Zhou and Haotian Peng and Yerun Gao and Ming Shao and Yu Yu}, doi = {10.1002/advs.202414285}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414285}, shortjournal = {Adv. Sci.}, title = {Direct-ink-writing printed stretchable eutectic Gallium–Indium antenna for robust wireless communication}, volume = {12}, year = {2025}, }
• (2025). GLS1-mediated redundancy in glutamate accelerates arterial calcification via activating NMDAR/Ca2+/β-catenin pathway. ADVS, 12(21), 2414252. (www)

  @article{ , abstract = {Arterial calcification is a powerful predictor of both the events and mortality associated with cardiovascular diseases in chronic kidney disease (CKD) patients. GLS1 (glutaminase 1), a rate-limiting enzyme catalyzing the conversion of glutamine to glutamate, is disordered in various cardiovascular diseases. However, the potential interplay between GLS1-mediated glutamate production and arterial calcification remains poorly understood. Here, LC-MS/MS analysis of CKD patients’ samples shows an abnormally elevated activity of GLS1, reflected by the increased glutamate/glutamine ratio. Moreover, GLS1 activity is positively correlated with arterial calcification progression, and its expression is upregulated in calcified arteries. Treatment with GLS1 inhibitors or knockdown of GLS1 alleviates osteogenic reprogramming. In contrast, glutamate administration boosts the development of arterial calcification. Mechanistically, GLS1 redundancy-regulated glutamate superfluity stimulates the activation of N-methyl-d-aspartate receptors (NMDAR), leading to Ca 2+ influx and extracellular regulated protein kinases (ERK) phosphorylation, followed by the nuclear translocation of β -Catenin and acceleration of osteogenic reprogramming of vascular smooth muscle cells (VSMCs) in further. This research defines GLS1 as a key contributor to arterial calcification. Glutamate, a major product of GLS1-mediated glutamine metabolism, exerts a deleterious effect on arterial calcification by activating NMDAR and subsequently triggering Ca 2+ influx, which in turn exacerbates β -Catenin-regulated osteogenic reprogramming in VSMCs.}, archive = {J_ADVS}, author = {Ziting Zhou and Bing Dong and Dayu He and Jianshuai Ma and Yun Kong and Huijin Zhu and Chen Xie and Tiecheng Yang and Xin Zhen and Zhengzhipeng Zhang and Zhaohui He and Jinkun Cheng and Aoran Huang and Jie Chen and Ruo Wu and Huiyong Yin and Yanlian Chen and Jun Tao and Hui Huang}, doi = {10.1002/advs.202414252}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414252}, shortjournal = {Adv. Sci.}, title = {GLS1-mediated redundancy in glutamate accelerates arterial calcification via activating NMDAR/Ca2+/β-catenin pathway}, volume = {12}, year = {2025}, }
• (2025). Facile fabrication of large-area and high-quality Organic–Inorganic hybrid perovskite ferroelectric films through electrohydrodynamic printing. ADVS, 12(21), 2414122. (www)

  @article{ , abstract = {Traditional oxide ferroelectrics have long struggled to produce flexible, large-area, and high-quality thin films at low temperatures, despite their good piezoelectric activity. Organic–inorganic hybrid perovskite ferroelectrics (OIHPFs), by contrast, are gaining popularity as promising candidates for next-generation flexible self-powered electric devices due to their easy solution-processability, structural adjustability, mechanical flexibility, and superior piezoelectric performance. However, their practical use is hindered by a lengthy single-crystal growing period and the absence of a truly effective large-area film manufacturing technique. To address these challenges, a simple electrohydrodynamic (EHD) printing technology is first proposed to in situ manufacture large-area, high-quality OIHPF crystals or flexible films at low temperatures, without substrate or size limitations. The obtained TMCM-CdBrCl 2 film has a high coverage of 99.83%. Notably, it has a crystallinity of 80.35% and a superior piezoelectric coefficient that is 72% and 5.8 times higher than that of the non-EHD-printed sample, respectively. The flexible piezoelectric nanogenerator (PENG) based on this film can endure over 200 000 bending cycles—the highest value recorded to date. This approach also shows strong feasibility and broad applicability in creating different OIHPF films or crystals, providing valuable scientific insight for the large-scale and integrated development of flexible OIHPF-based electronics.}, archive = {J_ADVS}, author = {Jingjing Luo and Zhongqi Ren and Xue Qi and Qiang Pan and Dong Li and Yuan Xiong and Jie Yao and Haipeng Liu and Suzhu Yu and Jun Wei}, doi = {10.1002/advs.202414122}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414122}, shortjournal = {Adv. Sci.}, title = {Facile fabrication of large-area and high-quality Organic–Inorganic hybrid perovskite ferroelectric films through electrohydrodynamic printing}, volume = {12}, year = {2025}, }
• (2025). Confinement by liquid-liquid interface replicates in vivo neutrophil deformations and elicits bleb-based migration. ADVS, 12(21), 2414024. (www)

  @article{ , abstract = {Leukocytes forge paths through interstitial spaces by exerting forces to overcome confining mechanical pressures provided by surrounding cells. While such mechanical cues regulate leukocyte motility, engineering an in vitro system that models the deformable cellular environment encountered in vivo has been challenging. Here, microchannels are constructed with a liquid-liquid interface that exerts confining pressures similar to cells in tissues, and thus, is deformable by cell-generated forces. Consequently, the balance between migratory cell-generated and interfacial pressures determines the degree of confinement. Pioneer cells that first contact the interfacial barrier require greater deformation forces to forge a path for migration, and as a result migrate slower than trailing cells. Critically, resistive pressures are tunable by controlling the curvature of the liquid interface, which regulates motility. By granting cells autonomy in determining their confinement, and tuning environmental resistance, interfacial deformations match those of surrounding cells in vivo during interstitial neutrophil migration in a larval zebrafish model. It is discovered that neutrophils employ a bleb-based mechanism of force generation to deform a soft barrier exerting cell-scale confining pressures. In all, this work introduces a tunable in vitro material interface that replicates confining pressures applied by soft tissue environments.}, archive = {J_ADVS}, author = {Jonathan H. Schrope and Adam Horn and Kaitlyn Lazorchak and Clyde W. Tinnen and Jack J Stevens and Mehtab Farooqui and Tanner Robertson and Jiayi Li and David Bennin and Terry Juang and Adeel Ahmed and Chao Li and Anna Huttenlocher and David J Beebe}, doi = {10.1002/advs.202414024}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2414024}, shortjournal = {Adv. Sci.}, title = {Confinement by liquid-liquid interface replicates in vivo neutrophil deformations and elicits bleb-based migration}, volume = {12}, year = {2025}, }
• (2025). High-fidelity computational microscopy via feature-domain phase retrieval. ADVS, 12(21), 2413975. (www)

  @article{ , abstract = {Computational microscopy enhances the space-bandwidth product and corrects aberrations for high-fidelity imaging by reconstructing complex optical wavefronts. Phase retrieval, a core technique in computational microscopy, faces challenges maintaining consistency between physical and real-world imaging formation, as physical models idealize real phenomena. The discrepancy between ideal and actual imaging formation limits the application of computational microscopy especially in non-ideal situations. Here, the feature-domain consistency for achieving high-fidelity computational microscopy is introduced. Feature-domain consistency tells that certain features, such as edges, textures, or patterns of an image, remain invariant in different image transformations, degradations, or representations. Leveraging the feature-domain consistency, Feature-Domain Phase Retrieval (FD-PR) is proposed, a framework applicable to various computational microscopy. Instead of working directly with images' pixel values, FD-PR uses image features to guide the reconstruction of optical wavefronts and takes advantage of invariance components of images against mismatches of physical models. Experimental studies, across diverse phase retrieval microscopic tasks, including coded/Fourier ptychography, inline holography, and aberration correction, demonstrate that FD-PR improves resolution by a factor of 1.5 and reduces noise levels by a factor of 2. The proposed framework can immediately benefit a wide range of computational microscopies, such as X-ray ptychography, diffraction tomography, and wavefront shaping.}, archive = {J_ADVS}, author = {Shuhe Zhang and An Pan and Hongbo Sun and Yidong Tan and Liangcai Cao}, doi = {10.1002/advs.202413975}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2413975}, shortjournal = {Adv. Sci.}, title = {High-fidelity computational microscopy via feature-domain phase retrieval}, volume = {12}, year = {2025}, }
• (2025). KLF1 promotes cardiomyocyte proliferation and heart regeneration through regulation of wnt/β-catenin signaling pathway. ADVS, 12(21), 2413964. (www)

  @article{ , abstract = {Innovative therapeutic approaches for heart failure, a leading cause of mortality worldwide, are urgently needed. In this study, the important role of Krüppel-like factor 1 (KLF1) in cardiomyocyte proliferation and heart regeneration is explored, and revealed its ability to regulate the Wnt/β-catenin signaling pathway as well as exploring a feasible strategy to target KLF1 for the treatment of heart failure. Postnatally, a marked decrease in KLF1 expression occurred almost simultaneously with a reduction in myocardial regenerative capacity. Through comprehensive in vivo and in vitro studies, it is demonstrated that in neonatal and adult mice, KLF1 overexpression significantly increased cardiomyocyte proliferation and promoted myocardial repair following infarction, whereas KLF1 knockout abolished these effects. Mechanistically, through RNA sequencing (RNA-seq) and ATAC sequencing (ATAC-seq) analyses, it is revealed that the promotion of cardiomyocyte proliferation by KLF1 is associated with the Wnt/β-catenin signaling pathway, mitochondrial function, and fatty acid metabolism. These findings highlight the important role of KLF1 in cardiomyocyte proliferation and heart regeneration, which provides novel insights into therapeutic targets for heart failure.}, archive = {J_ADVS}, author = {Yanglin Hao and Xi Zhang and Shuan Ran and Yuan Li and Weicong Ye and Song Wang and Xiaohan Li and Zilong Luo and Jiulu Zhao and Junjie Zong and Kexiao Zheng and Ran Li and Han Zhang and Longyong Lai and Pinyan Huang and Zifeng Zou and Wang Zhan and Zhang Yue and Jie Wu and Jiahong Xia}, doi = {10.1002/advs.202413964}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2413964}, shortjournal = {Adv. Sci.}, title = {KLF1 promotes cardiomyocyte proliferation and heart regeneration through regulation of wnt/β-catenin signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Meisoindigo acts as a molecular glue to target PKMYT1 for degradation in chronic myeloid leukemia therapy. ADVS, 12(21), 2413676. (www)

  @article{ , abstract = {Meisoindigo (Mei) has been clinically utilized for the treatment of chronic myeloid leukemia (CML), yet the precise molecular targets by which it exerts effects remain unclear. Through activity-based protein profiling (ABPP), the protein kinase, membrane-associated tyrosine/threonine 1 (PKMYT1) is identified as a direct target of Mei. Specifically, Mei forms a selective and reversible covalent bond with the Cys301 residue of PKMYT1, triggering its K48-linked polyubiquitination and accelerating proteasomal degradation, which is mediated by the E3 ligase TRIM25. The study reveals that Mei acts as a molecular glue, enhancing the interaction between PKMYT1 and TRIM25 by approximately 30-fold, thereby facilitating efficient PKMYT1 degradation. Further investigations reveal the pivotal role of PKMYT1 in cell growth. Knockdown of PKMYT1 in K562 cells induces G2/M phase arrest, enhances early apoptosis, and inhibits cell proliferation. In an orthotopic xenograft model, PKMYT1 knockdown delays leukemia progression and reduces lymph node metastasis, reinforcing its role in CML progression and metastasis. These findings provide a molecular rationale for the clinical efficacy of Mei and highlight PKMYT1 as a promising therapeutic target for CML. Additionally, it offers a valuable scaffold and inspiration for the development of novel molecular glue-based protein degraders.}, archive = {J_ADVS}, author = {Zhao-Xin Zhang and Shu-Ying Li and Fang-Fei Li and Qin-Yan Shi and Cheng-Yong Tan and Xiao-Jing Wang and Mi Li and Yun-Bao Liu and Jing Jin and Yong Li and Shi-Shan Yu}, doi = {10.1002/advs.202413676}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2413676}, shortjournal = {Adv. Sci.}, title = {Meisoindigo acts as a molecular glue to target PKMYT1 for degradation in chronic myeloid leukemia therapy}, volume = {12}, year = {2025}, }
• (2025). ZNHIT3 regulates translation to ensure cell lineage differentiation in mouse preimplantation development. ADVS, 12(21), 2413599. (www)

  @article{ , abstract = {Upon fertilization, the mouse zygotic genome is activated and maternal RNAs as well as proteins are degraded. Early developmental programs are built on proteins encoded by zygotic mouse genes that are needed to guide early cell fate commitment. The box C/D snoRNA ribonucleoprotein (snoRNP) complex is required for rRNA biogenesis, ribosome assembly and pre-mRNA splicing essential for protein translation. Zinc finger, HIT type 3 (encoded by Znhit3 ) is previously identified as a component in the assembly of the box C/D snoRNP complex. Using gene-edited mice, it identifies Znhit3 as an early embryonic gene whose ablation reduces protein translation and prevents mouse embryos development beyond the morula stage. The absence of ZNHIT3 leads to decreased snoRNA and rRNA abundance which causes defects of ribosomes and mRNA splicing. Microinjection of Znhit3 cRNA partially rescues the phenotype and confirms that ZNHIT3 is required for mRNA translation during preimplantation development.}, archive = {J_ADVS}, author = {Guanghui Yang and Qiliang Xin and Jurrien Dean}, doi = {10.1002/advs.202413599}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2413599}, shortjournal = {Adv. Sci.}, title = {ZNHIT3 regulates translation to ensure cell lineage differentiation in mouse preimplantation development}, volume = {12}, year = {2025}, }
• (2025). Targeting splenic myeloid cells with nanobiologics to prevent postablative pancreatic cancer recurrence via inducing antitumor peripheral trained immunity. ADVS, 12(21), 2413562. (www)

  @article{ , abstract = {Minimally invasive irreversible electroporation ablation shows promise for pancreatic cancer (PCa), but the high recurrence and metastasis rates pose a therapeutic challenge for loco-regional ablation treatment. Immunotherapy holds promise for preventing tumor recurrence, however, its efficacy against PCa remains limited. Here, using a preclinical model of PCa, it is identified that tumor development dramatically restructures the splenic immune landscape characterized by increased frequency of myeloid cells. Further, nanobiologics with high affinity for splenic myeloid cells using erythrocyte membrane fused with apoA1-modified liposomes are presented. Biocompatible CaCO 3 nanoparticles are incorporated to serve as a release reservoir of immunomodulatory therapeutics (muramyl dipeptide, MDP). The nanobiologics, MDCa@RBC-Alipo, induce antitumor-trained immunity by epigenetically and metabolically rewiring splenic myeloid cells, thereby overcoming the immunosuppressive tumor microenvironment in residual PCa following irreversible electroporation ablation. This approach enhances the therapeutic efficacy of aPD-L1 and significantly inhibits tumor recurrence and hemorrhagic ascites development. The trafficking of MDP directly to the spleen highlights a previously uncharacterized pathway for inducing peripheral trained immunity, thereby presenting a novel therapeutic approach for locally advanced PCa treatment.}, archive = {J_ADVS}, author = {Shengbo Wu and Weichen Xu and Xuexia Shan and Liping Sun and Shuo Liu and Xixi Sun and Shaoyue Li and Xiaodong Hou and Xiaowan Bo and Chengzhong Peng and Bin Huang and Huixiong Xu and Wenwen Yue}, doi = {10.1002/advs.202413562}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2413562}, shortjournal = {Adv. Sci.}, title = {Targeting splenic myeloid cells with nanobiologics to prevent postablative pancreatic cancer recurrence via inducing antitumor peripheral trained immunity}, volume = {12}, year = {2025}, }
• (2025). Exploring the latent information in spatial transcriptomics data via multi-view graph convolutional network based on implicit contrastive learning. ADVS, 12(21), 2413545. (www)

  @article{ , abstract = {Latest developments in spatial transcriptomics enable thoroughly profiling of gene expression while preserving tissue microenvironment. Connecting gene expression with spatial arrangement is key for precise spatial domain identification, enhancing the comprehension of tissue microenvironments and biological processes. However, accurately analyzing spatial domains with similar gene expression and histological features is still challenging. This study introduces STMIGCL, a novel framework that leverages a multi-view graph convolutional network and implicit contrastive learning. First, it creates neighbor graphs from gene expression and spatial coordinates, and then combines these with gene expression through multi-view learning to learn low-dimensional representations. To further refine the obtained low-dimensional representations, a graph contrastive learning method with contrastive enhancement in the latent space is employed, aiming to better capture critical information in the data and improve the accuracy and discriminative power of the embeddings. Finally, an attention mechanism is used to adaptively integrate different views, capturing the importance of spots in various views to obtain the final spot representation. Experimental data confirms that STMIGCL significantly enhances spatial domain recognition precision and outperforms all baseline methods in tasks such as trajectory inference and Spatially Variable Genes (SVGs) recognition.}, archive = {J_ADVS}, author = {Sheng Ren and Xingyu Liao and Farong Liu and Jie Li and Xin Gao and Bin Yu}, doi = {10.1002/advs.202413545}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2413545}, shortjournal = {Adv. Sci.}, title = {Exploring the latent information in spatial transcriptomics data via multi-view graph convolutional network based on implicit contrastive learning}, volume = {12}, year = {2025}, }
• (2025). KDM6A deficiency induces myeloid bias and promotes CMML-like disease through JAK/STAT3 activation by repressing SOCS3. ADVS, 12(21), 2413091. (www)

  @article{ , abstract = {Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy with a poor prognosis and limited targeted therapies. Lysine demethylase 6A (KDM6A), a H3K27 demethylase and key component of the COMPASS complex, is frequently mutated in hematologic malignancies, but its roles in embryonic hematopoiesis and tumor suppression in CMML remain unclear. Using zebrafish models with kdm6a mutants and integrative multi-omics analysis (ATAC-seq, RNA-seq, ChIP), we find that Kdm6a is a critical positive regulator of hematopoietic stem and progenitor cell (HSPC) emergence via Syk-related inflammatory signaling in a H3K27me3-dependent manner. We further find that Kdm6a haploinsufficiency in zebrafish leads to myeloid-biased hematopoiesis and a CMML-like disease, similar to CMML patients with reduced KDM6A expression. This KDM6A haploinsufficiency also significantly alters the chromatin landscape of genes associated with aging and cellular homeostasis in HSPCs. Mechanistically, KAM6A haploinsufficiency represses SOCS3 expression, thereby activating JAK/STAT3 signaling in HSPCs. Importantly, inhibitors targeting JAK or STAT3 phosphorylation alleviate myeloid expansion, providing a rationale for JAK/STAT pathway inhibition in CMML therapy. These findings enhance our understanding of CMML pathogenesis and propose new therapeutic avenues.}, archive = {J_ADVS}, author = {Huiqiao Chen and Shufen Wang and Ruoyu Dong and Pinhui Yu and Tianyu Li and Liangning Hu and Mowang Wang and Zijun Qian and Hongyu Zhou and Xiaoyan Yue and Limengmeng Wang and Haowen Xiao}, doi = {10.1002/advs.202413091}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2413091}, shortjournal = {Adv. Sci.}, title = {KDM6A deficiency induces myeloid bias and promotes CMML-like disease through JAK/STAT3 activation by repressing SOCS3}, volume = {12}, year = {2025}, }
• (2025). Histone deacetylase 6 (HDAC6) in ciliopathies: Emerging insights and therapeutic implications. ADVS, 12(21), 2412921. (www)

  @article{ , abstract = {HDAC6 is integral to the regulation of primary cilia, which are specialized structures that serve as crucial signaling hubs for cellular communication and environmental response. These ciliary functions are essential for maintaining cellular homeostasis and orchestrating developmental processes. Dysregulation of HDAC6 activity is implicated in ciliopathies, a group of disorders characterized by defective ciliary structure or function, resulting in widespread organ involvement and significant morbidity. This review provides a comprehensive examination of the molecular dynamics of HDAC6 in the context of ciliogenesis and ciliopathies, emphasizing its dual role in the deacetylation of microtubules and regulation of the ciliary axoneme. Furthermore, HDAC6 interacts with key signaling molecules, modulating processes ranging from cell cycle regulation to inflammatory responses, which highlights its central role in cellular physiology and pathology. The therapeutic potential of HDAC6 inhibitors has been explored, with promising results in various disease models, including retinal and renal ciliopathies, highlighting their ability to restore normal ciliary function. This analysis not only underscores the critical importance of HDAC6 in maintaining ciliary integrity but also illustrates how targeting the HDAC6-cilia axis could provide a groundbreaking approach to treating these complex disorders. In doing so, this review sets the stage for future investigations into HDAC6-targeted therapies, potentially transforming the clinical management of ciliopathies and significantly improving patient outcomes.}, archive = {J_ADVS}, author = {Zhiyi Wang and Xiaofan Zhu and Zhenzhou Huang and Kaidi Ren and Jie Ran and Yang Yang}, doi = {10.1002/advs.202412921}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2412921}, shortjournal = {Adv. Sci.}, title = {Histone deacetylase 6 (HDAC6) in ciliopathies: Emerging insights and therapeutic implications}, volume = {12}, year = {2025}, }
• (2025). Gut microbiota colonization in early life influences susceptibility to adulthood hepatic lipid accumulation in high-fat-diet-fed mice. ADVS, 12(21), 2412827. (www)

  @article{ , abstract = {The global prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) has a rising trend. The Developmental Origins of Health and Disease (DOHaD) theory assumes that MAFLD develops throughout the entire lifecycle but it originates in early life. This study aimed to investigate the influence of early-life gut microbiota colonization on the susceptibility to adulthood hepatic lipid accumulation in high-fat-diet (HFD)-fed mice. The results showed that perinatal AM exposure exacerbated adulthood hepatic lipid accumulation and altered hepatic lipid profile in HFD-fed male but not female offspring. Perinatal AM exposure does not affect hepatic lipid metabolic genes in adult offspring. Instead, perinatal AM exposure inhibited intestinal bile acid (BA) metabolism to reduce secondary BAs production, thereby promoting dietary lipid absorption. Mechanistically, perinatal AM exposure permanently reduces species diversity of the microbial community and impairs its structure and function by disrupting early-life gut microbiota colonization. Supplementing Lactobacillus during lactation improved gut microbiota colonization and intestinal BA metabolism, thereby alleviating HFD-induced hepatic lipid deposition. These results suggest that disruption of early-life gut microbiota colonization elevates susceptibility to adulthood hepatic lipid accumulation by promoting intestinal lipid absorption in HFD-fed mice. Supplementing probiotics during lactation may be an effective strategy for preventing susceptibility to adulthood MAFLD.}, archive = {J_ADVS}, author = {Yan-Yan Zhu and Xin Dong and Hao Zhou and Ze-Yan Li and Bo Wang and Ya-Ping Song and Zhi-Bing Liu and Xue Lu and Yi-Hao Zhang and Yichao Huang and Hua Wang and De-Xiang Xu}, doi = {10.1002/advs.202412827}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2412827}, shortjournal = {Adv. Sci.}, title = {Gut microbiota colonization in early life influences susceptibility to adulthood hepatic lipid accumulation in high-fat-diet-fed mice}, volume = {12}, year = {2025}, }
• (2025). Multicargo porous cochlear electrode coating for antifibrosis after cochlear implantation. ADVS, 12(21), 2412158. (www)

  @article{ , abstract = {Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA-PDMS)-coated cochlear electrode is presented for CI and hearing protection. The porous MA-PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti 3 C 2 T x MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug-loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system.}, archive = {J_ADVS}, author = {Lei Ren and Yangnan Hu and Xiaoqiong Ding and Menghui Liao and Tian Shen and Sixing Cao and Hui Zhang and Hong Cheng and Yanru Qi and Pan Feng and Xinyi Pang and Ling Lu and Huan Wang and Wenwen Liu and Renjie Chai and Lin Cheng}, doi = {10.1002/advs.202412158}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2412158}, shortjournal = {Adv. Sci.}, title = {Multicargo porous cochlear electrode coating for antifibrosis after cochlear implantation}, volume = {12}, year = {2025}, }
• (2025). Enhancer profiling reveals a protective role of RXRα against calcium oxalate-induced crystal deposition and kidney injury. ADVS, 12(21), 2411735. (www)

  @article{ , abstract = {During the formation of kidney stones, the interaction between crystals and tubular epithelial cells (TECs) leads to tubular injury and dysfunction, which in turn promote stone formation. However, the molecular mechanisms underlying these changes in TECs remain elusive. Drug screening revealed that JQ1 inhibited the adhesion of calcium oxalate (CaOx) crystals to TECs. Its therapeutic effect is further confirmed in a glyoxylic acid-induced CaOx crystal deposition mouse model. Utilizing epigenomic and transcriptomic profiling, dynamic enhancer landscape and gene expression program associated with nephrolithiasis are charted. Bioinformatic analysis pinpointing the RXRα as a central transcription factor (TF) modulating enhancer activity. Importantly, the animal studies revealed that RXRα deletion promoted the CaOx crystal deposition, while its activation by Bexarotene (Bex), an FDA-approved drug, mitigated this progression. Mechanistically, under normal circumstances, RXRα inhibited nephrolithiasis-promoting genes by recruiting the HDAC3/SMART complex to repress enhancer activity. Yet, with the progression of CaOx crystal deposition, RXRα expression decreased, leading to enhancer activation and subsequent upregulation of nephrolithiasis-promoting genes. In summary, the work illustrates an epigenetic mechanism underlying TECs fate transition during CaOx crystal deposition and highlights the therapeutic potential of JQ1 and Bex in managing kidney stone diseases.}, archive = {J_ADVS}, author = {Yu Yang and Xudan Dou and Yongzhan Sun and Mengyao Wang and Jing Wang and Xinyi Cao and Haijie Xie and Linguo Xie and Weiping Tian and Jing Nie and Yupeng Chen and Chunyu Liu and Lirong Zhang}, doi = {10.1002/advs.202411735}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2411735}, shortjournal = {Adv. Sci.}, title = {Enhancer profiling reveals a protective role of RXRα against calcium oxalate-induced crystal deposition and kidney injury}, volume = {12}, year = {2025}, }
• (2025). Two steps li ion storage mechanism in Ruddlesden–Popper Li2La2Ti3O10. ADVS, 12(21), 2410543. (www)

  @article{ , abstract = {Innovative anode materials are essential for achieving high-energy-density lithium-ion batteries (LIBs) with longer lifetimes. Thus far, only a few studies have explored the use of layered perovskite structures as LIB anode materials. In this study, the study demonstrates the performance and charge/discharge mechanism of the previously undefined Ruddlesden-Popper Li₂La₂Ti₃O₁₀ (RPLLTO) as an anode material for LIBs. RPLLTO exhibits two unique voltage plateaus ≈0.6 and 0.4 V(vs Li/Li + ), due to the insertion of lithium ions into different sites within its layered structure. The electrical state of Ti is analyzed using X-ray photoelectron spectroscopy and X-ray absorption near edge spectra, revealing a reduction from Ti⁴⁺ to Ti 2 ⁺, corresponding to a capacity of 170 mAh·g⁻¹. In situ X-ray diffraction patterns and extended X-ray absorption fine structure spectra demonstrate the crystal structure changes during lithiation. Complementary expansion along the a/b axes and contraction along the c axis result in a volume change of only 4%. This structural stability is evidenced by an 88% capacity retention after 1000 cycles. This study successfully showcases the lithium-ion storage capability of RPLLTO and contributes to the development of perovskite anode materials with diverse compositions and structures.}, archive = {J_ADVS}, author = {Mi Jang and Sunhyun Hwang and Ji Su Chae and Gun Jang and Ho Seok Park and Younki Lee and JungHyun Choi and Won-Sub Yoon and Kwang Chul Roh}, doi = {10.1002/advs.202410543}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2410543}, shortjournal = {Adv. Sci.}, title = {Two steps li ion storage mechanism in Ruddlesden–Popper Li2La2Ti3O10}, volume = {12}, year = {2025}, }
• (2025). Computational modeling and experimental approaches for understanding the mechanisms of [FeFe]-hydrogenase. ADVS, 12(21), 2408297. (www)

  @article{ , abstract = {Learning from nature has emerged as a promising strategy for catalyst development, wherein the remarkable performance of catalysts selected by nature over billions of years of evolution serves as a basis for the creative design of high-performance catalysts. Hydrogenases, with their exceptional catalytic activity in hydrogen oxidation and production, have been employed as prototypes for human learning to achieve better catalyst design. A comprehensive understanding of hydrogenases' structures and catalytic mechanisms is crucial to replicate and exceed their performance. Computational modeling has proven to be a powerful tool for elucidating the reduction chemistry of [FeFe]-hydrogenases. This review overviews recent computational and experimental efforts, focusing on density functional theory (DFT) calculations applied to [FeFe] hydrogenases. It summarizes current knowledge on identifying active sites in [FeFe] hydrogenases and the reaction cycles involved in hydrogen metabolism.}, archive = {J_ADVS}, author = {Chang-Ah Kim and Jiabin Wu and Jun Zhu and Huaiguang Li and Zhihai Ke}, doi = {10.1002/advs.202408297}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2408297}, shortjournal = {Adv. Sci.}, title = {Computational modeling and experimental approaches for understanding the mechanisms of [FeFe]-hydrogenase}, volume = {12}, year = {2025}, }
• (2025). Activation of glutamatergic neurons in the supramammillary nucleus promotes the recovery of consciousness under sevoflurane anesthesia. ADVS, 12(21), 2406959. (www)

  @article{ , abstract = {Volatile anesthetics have been widely applied during surgery, but the potential mechanisms by which they influence loss of consciousness (LOC), anesthesia maintenance, and recovery of consciousness (ROC) from anesthesia remain largely unknown. Recent studies have suggested that anesthesia-induced unconsciousness may be due to specific interactions between neural circuits that regulate sleep and wakefulness. Supramammillary (SuM) glutamatergic neurons are essential for sleep-wakefulness regulation. However, whether SuM glutamatergic neurons are involved in the modulation of consciousness under sevoflurane anesthesia is unclear. Here, it is shown that the activity of SuM glutamatergic neurons decreased prior to sevoflurane-induced LOC and gradually increased following ROC. Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. In addition, optogenetic stimulation of SuM glutamatergic neurons or the SuM-MS projection promoted behavioral arousal and cortical activation under steady-state sevoflurane anesthesia (SSSA) and reduced the depth of anesthesia and caused cortical arousal under sevoflurane-induced burst-suppression conditions. Collectively, these results provide compelling evidence that SuM glutamatergic neurons contribute to regulating states of consciousness under sevoflurane anesthesia.}, archive = {J_ADVS}, author = {Jiayan Li and Yehui Wu and Yihan Wang and Yumin Wu and Rong Hu and Si Long and Wenqi Huang and Liming Nie and Zhongxing Wang}, doi = {10.1002/advs.202406959}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2406959}, shortjournal = {Adv. Sci.}, title = {Activation of glutamatergic neurons in the supramammillary nucleus promotes the recovery of consciousness under sevoflurane anesthesia}, volume = {12}, year = {2025}, }
• (2025). Lipid droplet-derived biomimetic nanocarriers for the enhancement of porcine intermuscular fat content. ADVS, 12(21), 2406150. (www)

  @article{ , abstract = {Intramuscular fat (IMF) content is a critical factor influencing the quality and palatability of pork. However, established breeding and nutritional methods lead to systemic fat deposition. The efficient and specific methods to increase IMF content in livestock remain a challenge. In this study, Lipid droplets (LDs), an organelle in cells, are shown to be a controllable and biocompatible carrier that can be used to increase IMF content. This study demonstrated that isolated LDs stimulate lipid synthesis by encapsulating Oleic Acid (OA), a PPARγ ligand. Importantly, artificial LDs (aLDs) can effectively substitute isolated LDs. In vivo, investigations showed that OA-loading aLDs significantly increased the expression of lipid synthases such as DGAT2 and FASN through activation of PPARγ, a key pathway for lipid synthesis. Furthermore, the IMF content on the injected side is increased up to 35% with minimal side effects. The development of OA-aLDs promotes IMF deposition and demonstrates the significant potential of aLDs as drug carriers. The exploration of LDs-based carriers provides a new theoretical basis for their application in the medical field.}, archive = {J_ADVS}, author = {Pengxiang Zhao and Hongbo Han and Jingjie Hao and Ziwei Yu and Zichen Zhao and Lupeng Chen and Heng Wang and Jian Wu and Zhuqing Ren}, doi = {10.1002/advs.202406150}, journal = {Advanced Science}, month = {6}, number = {21}, pages = {2406150}, shortjournal = {Adv. Sci.}, title = {Lipid droplet-derived biomimetic nanocarriers for the enhancement of porcine intermuscular fat content}, volume = {12}, year = {2025}, }
• (2025). Structural diversity of mitochondria in the neuromuscular system across development revealed by 3D electron microscopy (Adv. sci. 20/2025). ADVS, 12(20), 2570157. (www)

  @article{ , archive = {J_ADVS}, author = {J. Alexander Bae and Myung-kyu Choi and Soungyub Ahn and Gwanho Ko and Daniel T. Choe and Hyunsoo Yim and Ken C. Nguyen and Jinseop S. Kim and David H. Hall and Junho Lee}, doi = {10.1002/advs.202570157}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570157}, shortjournal = {Adv. Sci.}, title = {Structural diversity of mitochondria in the neuromuscular system across development revealed by 3D electron microscopy (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). The semi-natural climate chambers across latitudes: A broadly applicable husbandry and experimental system for terrestrial ectotherms under climate change (Adv. sci. 20/2025). ADVS, 12(20), 2570156. (www)

  @article{ , archive = {J_ADVS}, author = {Bao-Jun Sun and Hong-Liang Lu and Kun-Ming Cheng and Wan-Li Liu and Xing-Zhi Han and Luo-Xin Cui and Xing-Han Li and Shu-Ran Li and Xin Hao and Fan Li and Dan-Yang Wu and Teng Li and Yong-Pu Zhang and Ji-Chao Wang and Peng Liu and Wei-Guo Du}, doi = {10.1002/advs.202570156}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570156}, shortjournal = {Adv. Sci.}, title = {The semi-natural climate chambers across latitudes: A broadly applicable husbandry and experimental system for terrestrial ectotherms under climate change (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). Transcriptome landscape of cancer-associated fibroblasts in human PDAC (Adv. sci. 20/2025). ADVS, 12(20), 2570155. (www)

  @article{ , archive = {J_ADVS}, author = {Mengyu Tao and Wenting Liu and Jianhua Chen and Rujiao Liu and Jianling Zou and Bo Yu and Chenchen Wang and Mingzhu Huang and Qingjian Chen and Zhe Zhang and Zhiyu Chen and Haoyu Sun and Cheng Zhou and Shuguang Tan and Yuxuan Zheng and Hongxia Wang}, doi = {10.1002/advs.202570155}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570155}, shortjournal = {Adv. Sci.}, title = {Transcriptome landscape of cancer-associated fibroblasts in human PDAC (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). Tunable polariton rabi oscillation in phase-changing perovskite microcavities (Adv. sci. 20/2025). ADVS, 12(20), 2570154. (www)

  @article{ , archive = {J_ADVS}, author = {Hyeon-Seo Choi and Minjee Ko and Taejin Lee and Jin-Woo Jung and Young-Jun Lee and Hyeonjong Jeong and Youngjae Kim and Dongha Kim and Jinhee Heo and Shinbuhm Lee and JaeDong Lee and Chang-Hee Cho}, doi = {10.1002/advs.202570154}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570154}, shortjournal = {Adv. Sci.}, title = {Tunable polariton rabi oscillation in phase-changing perovskite microcavities (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). Deciphering the transcription factor landscape in prostate cancer progression: A novel approach to understand NE transdifferentiation (Adv. sci. 20/2025). ADVS, 12(20), 2570153. (www)

  @article{ , archive = {J_ADVS}, author = {Yu Wang and Hui Xue and Xiaohui Zhu and Dong Lin and Zheng Chen and Xin Dong and Junru Chen and Mingchen Shi and Yuchao Ni and Jonathan Cao and Rebecca Wu and Connie Kang and Xinyao Pang and Francesco Crea and Yen-Yi Lin and Colin C. Collins and Martin E. Gleave and Abhijit Parolia and Arul Chinnaiyan and Christopher J. Ong and Yuzhuo Wang}, doi = {10.1002/advs.202570153}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570153}, shortjournal = {Adv. Sci.}, title = {Deciphering the transcription factor landscape in prostate cancer progression: A novel approach to understand NE transdifferentiation (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). Gut microbiota-butyrate-PPARγ axis modulates adipose regulatory t cell population (Adv. sci. 20/2025). ADVS, 12(20), 2570151. (www)

  @article{ , archive = {J_ADVS}, author = {Banru Chen and Lizhi Guan and Chao Wu and Yiwen Gong and Lei Wu and Minchun Zhang and Zhiwen Cao and Yufei Chen and Chengcan Yang and Bing Wang and Yunqi Li and Bin Li and Yufang Bi and Guang Ning and Jiqiu Wang and Weiqing Wang and Ruixin Liu}, doi = {10.1002/advs.202570151}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570151}, shortjournal = {Adv. Sci.}, title = {Gut microbiota-butyrate-PPARγ axis modulates adipose regulatory t cell population (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). Delivery of a chemically modified noncoding RNA domain improves dystrophic myotube function (Adv. sci. 20/2025). ADVS, 12(20), 2570150. (www)

  @article{ , archive = {J_ADVS}, author = {Zeinabou Niasse-Sy and Bo Zhao and Ajda Lenardič and Huyen Thuc Tran Luong and Ori Bar-Nur and Johan Auwerx and Martin Wohlwend}, doi = {10.1002/advs.202570150}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570150}, shortjournal = {Adv. Sci.}, title = {Delivery of a chemically modified noncoding RNA domain improves dystrophic myotube function (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). Catheter injectable multifunctional biomaterial for the treatment of infected enterocutaneous fistulas (Adv. sci. 20/2025). ADVS, 12(20), 2570149. (www)

  @article{ , archive = {J_ADVS}, author = {Jinjoo Kim and Zefu Zhang and Hassan Albadawi and Hyeongseop Keum and Joseph L. Mayer and Erin H. Graf and Rahmi Oklu}, doi = {10.1002/advs.202570149}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570149}, shortjournal = {Adv. Sci.}, title = {Catheter injectable multifunctional biomaterial for the treatment of infected enterocutaneous fistulas (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). Laser-enabled fabrication of flexible printed electronics with integrated functional devices (Adv. sci. 20/2025). ADVS, 12(20), 2570148. (www)

  @article{ , archive = {J_ADVS}, author = {Wedyan Babatain and Christine Park and Hiroshi Ishii and Neil Gershenfeld}, doi = {10.1002/advs.202570148}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2570148}, shortjournal = {Adv. Sci.}, title = {Laser-enabled fabrication of flexible printed electronics with integrated functional devices (Adv. sci. 20/2025)}, volume = {12}, year = {2025}, }
• (2025). Drug screening of primary human endometriotic cells based on micro-encapsulating microfluidic chip. ADVS, 12(20), 2504647. (www)

  @article{ , abstract = {Endometriosis (EMs), a significant global health issue, characterized by unclear pathogenesis, nonspecific symptoms, and poor treatment outcomes. The organ-on-chip technology has achieved great advances in disease modeling, yet its potential in EMs-related research remains largely untapped. Herein, a microfluidic chip platform that integrates primary cell-laden microcapsules for personalized drug evaluation. Specifically, primary human ectopic endometrial stromal cells (hESCs) within microcapsules featuring a biocompatible carboxymethyl cellulose (CMC) core and a stable alginate (ALG) shell using precise microfluidic electrospray are encapsulated. These microcapsules are integrated into a chip with a branched gradient generator and multiple cell-culture chambers, enabling tailored and high-throughput drug screening. By exposing hESCs-microcapsules derived from primary cells of distinct patient individuals to various drugs on-chip, significant inter-individual variability was revealed, with a strong correlation to clinical outcomes. This unique combination of patient-specific 3D microenvironments and dynamic drug gradient control represents a paradigm shift in personalized EMs research. Further integrating with omics techniques, its capability in exploring promising drugs is showcased. These results reveal that the chip platform could deliver dependable and personalized drug screening outcomes, thereby benefiting both scientific inquiries and clinical therapies.}, archive = {J_ADVS}, author = {Qiong Chen and Jing Wang and Wenzhao Li and Luoran Shang and Dexuan Wang and Ping Duan}, doi = {10.1002/advs.202504647}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2504647}, shortjournal = {Adv. Sci.}, title = {Drug screening of primary human endometriotic cells based on micro-encapsulating microfluidic chip}, volume = {12}, year = {2025}, }
• (2025). Correction to “Peptide transporter 1-mediated dipeptide transport promotes hepatocellular carcinoma metastasis by activating MAP4K4/G3BP2 signaling axis”. ADVS, 12(20), 2504116. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202504116}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2504116}, shortjournal = {Adv. Sci.}, title = {Correction to “Peptide transporter 1-mediated dipeptide transport promotes hepatocellular carcinoma metastasis by activating MAP4K4/G3BP2 signaling axis”}, volume = {12}, year = {2025}, }
• (2025). Correction to “AAV-mediated gene therapy restores hearing in patients with DFNB9 deafness”. ADVS, 12(20), 2504047. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202504047}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2504047}, shortjournal = {Adv. Sci.}, title = {Correction to “AAV-mediated gene therapy restores hearing in patients with DFNB9 deafness”}, volume = {12}, year = {2025}, }
• (2025). Biomedical applications of gadolinium-containing biomaterials: Not only MRI contrast agent. ADVS, 12(20), 2501722. (www)

  @article{ , abstract = {The potential applications of rare earth elements (REEs) in biomedical fields have been intensively investigated. Numerous studies have shown that doping biomaterials with REEs can enhance their properties. Gadolinium (Gd) is a biocompatible REE that holds promise in biomedical applications. This review examines the use of Gd-doped biomaterials in osteogenic, antimicrobial, anticancer applications, and in bioimaging and bioprobes, as reported in the literature until December 2024. The included studies demonstrate that Gd-containing biomaterials promote osteogenesis, enhance antimicrobial properties, and perform well in anticancer applications and bioimaging. Taken together, they point to the considerable potential of Gd-doped biomaterials and thus to avenues for future research.}, archive = {J_ADVS}, author = {Xingtong Pan and Menglong Hu and Likun Wu and Erfan Wei and Qiyue Zhu and Letian Lv and Xiuyun Xv and Xinyi Dong and Hao Liu and Yunsong Liu}, doi = {10.1002/advs.202501722}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2501722}, shortjournal = {Adv. Sci.}, title = {Biomedical applications of gadolinium-containing biomaterials: Not only MRI contrast agent}, volume = {12}, year = {2025}, }
• (2025). Surfactant-assisted construction of covalent organic frameworks. ADVS, 12(20), 2501580. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs), characterized by their unique ordered pore structures, chemical diversity, and high degree of designability, have demonstrated immense application potential across multiple fields. However, traditional synthesis methods often encounter challenges such as low crystallinity and uneven morphology. The introduction of surfactants has opened up new pathways for the synthesis of COFs. Leveraging their intermolecular interactions and self-assembly properties, surfactants can effectively regulate the nucleation, growth processes, and ultimate structure and properties of COFs. This paper systematically reviews the latest research achievements and future trends in surfactant-assisted COF synthesis, emphasizing the crucial role of surfactants as key additives in the preparation of COFs. Surfactants not only facilitate uniform nucleation and growth of COFs, enhancing the crystallinity and structural order of the products but also enable precise and diverse regulation of the dimensionality, morphology, and structure of COFs. Furthermore, by influencing the dispersion and processability of COFs, surfactants enhance their practicality and workability. Finally, the paper presents some prospects for the challenges and future opportunities in this emerging research area.}, archive = {J_ADVS}, author = {Youqi Li and Qingqing Zhang and Zhendong Dai and Renzhong Wang and Zhaohua Li and Yu Huang and Runchen Lai and Facai Wei and Feng Shao}, doi = {10.1002/advs.202501580}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2501580}, shortjournal = {Adv. Sci.}, title = {Surfactant-assisted construction of covalent organic frameworks}, volume = {12}, year = {2025}, }
• (2025). Lignin-based photothermal materials: Bridging sustainability and high-efficiency energy conversion. ADVS, 12(20), 2501259. (www)

  @article{ , abstract = {Photothermal materials can effectively absorb light and convert it into heat, providing sustainable solutions to mitigate environmental pollution and energy shortages. Compared to traditional photothermal materials, lignin has garnered significant attention due to its wide availability, low cost, biocompatibility, renewability, and sustainability. Consequently, lignin-based materials are considered ideal candidates for the development of eco-friendly photothermal systems, aligning well with the increasing demand for sustainable energy solutions. This review discusses the potential of lignin-based photothermal materials, highlighting their unique molecular structure and the photothermal properties imparted by their aromatic rings, which facilitate effective energy conversion through non-radiative vibrational relaxation. Discussed the latest advances in the applications of lignin photothermal materials in photothermal drive, solar desalination, and biomedicine. Despite the significant potential of lignin, challenges such as structural variability, long-term stability, and scalability remain critical. This paper integrates recent progress and proposes strategies to optimize the photothermal performance of lignin-based materials, while emphasizing important directions for sustainable development, thereby providing a roadmap to fully realize the potential of lignin in next-generation green technologies.}, archive = {J_ADVS}, author = {Zhiwen Sun and Changyou Shao and Sanwei Hao and Jifei Zhang and Wenfeng Ren and Bing Wang and Lingping Xiao and Hanhui Lei and Terence X. Liu and Zhanhui Yuan and Run-cang Sun}, doi = {10.1002/advs.202501259}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2501259}, shortjournal = {Adv. Sci.}, title = {Lignin-based photothermal materials: Bridging sustainability and high-efficiency energy conversion}, volume = {12}, year = {2025}, }
• (2025). From multi-omics to visualization and beyond: Bridging micro and macro insights in CAR-T cell therapy. ADVS, 12(20), 2501095. (www)

  @article{ , abstract = {Chimeric antigen receptor T (CAR-T) cell therapies, a cornerstone of immunotherapy, have demonstrated remarkable efficacy in treating hematological malignancies and have more recently expanded into applications for solid tumors and autoimmune diseases. Emerging multidimensional profiling technologies offer promising solutions for enhancing CAR-T efficacy, overcoming resistance, and facilitating the development of novel CAR-T constructs. The integration of genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics enables a comprehensive understanding of the intrinsic mechanisms underlying CAR-T therapy, while single-cell and spatial omics significantly improve data resolution and analytical depth. Coupled with advances in biomedical engineering, visualization technologies form the foundation for omics data generation by bridging microscopic and macroscopic scales and enabling dynamic, 3D in vivo monitoring of CAR-T behavior. Artificial intelligence (AI) further supports this framework by enabling the analysis of complex, high-dimensional datasets. This review highlights recent advances in the integration of multidimensional omics within CAR-T therapy and explores cutting-edge developments in visualization technologies and AI applications. The full convergence of multi-omics, visualization tools, and AI is poised to deliver transformative insights into the mechanisms governing CAR-T cell therapy.}, archive = {J_ADVS}, author = {Yuting Gong and Peng Fei and Yicheng Zhang and Yang Xu and Jia Wei}, doi = {10.1002/advs.202501095}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2501095}, shortjournal = {Adv. Sci.}, title = {From multi-omics to visualization and beyond: Bridging micro and macro insights in CAR-T cell therapy}, volume = {12}, year = {2025}, }
• (2025). Prussian-blue catalysis and NFC synergy: A battery-free laser-induced graphene-based platform for urine glucose monitoring at point-of-care. ADVS, 12(20), 2500365. (www)

  @article{ , abstract = {Prussian-blue nanoparticles (PBNPs) show promise in electrochemical hydrogen peroxide (H 2 O 2 ) sensing but face operational stability challenges without complex strategies. This study introduces a simplified, polymer-based synthesis method, enhancing their stability in a single step. Chemical polymerization of Prussian-blue (PB) and poly(3,4-ethylenedioxythiophene) (PEDOT) with gelatin as a polycationic soft template yields a self-assembled PB-infused Catalytic Hetero-interface Architecture (PB-CHIA) that remarkably improves the stability of PBNPs and offers functional groups for enzyme immobilization, supporting robust biosensing applications. The softened PEDOT rigidity extends PB-CHIA's applicability to various carbonaceous electrode substrates, including glassy carbon and laser-induced graphene (LIG) via simple drop-casting. A fluidic cell module designed with the optimized LIG morphology (nano-fibrous fringes, LIG-F, diameter: 72.87 ± 12.24 nm) modified with PB-CHIA and glucose oxidase enables non-invasive urine glucose monitoring. The configuration accurately quantifies glucose within a linear range of 10–400 µM [R 2 : 0.991, Sensitivity: 29.88 ± 4.98 µA mM⁻¹ cm⁻ 2 , Detection Limit: 4.52 ± 2.24 µM], covering medical needs. A near-field communication potentiostat is devised for a fully integrated, batteryless, wireless point-of-care (POC) prototype, enabling rapid smartphone readouts in 15 s for daily home-based use. The stable operation of PB-CHIA allows working electrodes’ scalable production, highlighting its potential for diverse POC devices in urinary analysis reliant on H 2 O 2 assays.}, archive = {J_ADVS}, author = {Sinan Uzunçar and Gabriel Maroli and Massimo Urban and Arben Merkoçi}, doi = {10.1002/advs.202500365}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2500365}, shortjournal = {Adv. Sci.}, title = {Prussian-blue catalysis and NFC synergy: A battery-free laser-induced graphene-based platform for urine glucose monitoring at point-of-care}, volume = {12}, year = {2025}, }
• (2025). Design, synthesis, and application of immobilized enzymes on artificial porous materials. ADVS, 12(20), 2500345. (www)

  @article{ , abstract = {Enzymes have been recognized as highly efficient biocatalysts, whereas characteristics such as poor stability and single reaction type greatly significantly limit their wide application. Hence, the exploitation of suitable carriers for immobilized enzymes enables the provision of a protective layer for the enzyme, with the capability of chemical and biological cascade catalysis. Among the various immobilization carriers, metal-organic frameworks (MOFs), covalent organic frameworks (COFs) and hydrogen-bonded organic frameworks (HOFs) have been emerging as a promising strategy to surpass the inherent instability and other limitations of free enzymes. Specifically, the integration of such artificial porous materials as carriers improves the stability and reusability of enzymes, while simultaneously affording a platform for multifunctional applications. Herein, this review systematically discusses the various preparation strategies and advantages of artificial porous materials, while elucidating the effects of different immobilization methods on enzyme activity. Furthermore, the innovative applications of artificial porous materials as multifunctional carriers in the field of enzyme immobilization fields such as enzyme carriers, photocatalysts, chemical catalysts and sensing are also comprehensively summarized here, thus demonstrating their multifunctional characteristics and promising applications in addressing complex biotransformation challenges.}, archive = {J_ADVS}, author = {Lu Ran and Yuan Lu and Li Chen and Mengru He and Zhangshuang Deng}, doi = {10.1002/advs.202500345}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2500345}, shortjournal = {Adv. Sci.}, title = {Design, synthesis, and application of immobilized enzymes on artificial porous materials}, volume = {12}, year = {2025}, }
• (2025). High radiation resistance in the binary W-ta system through small v additions: A new paradigm for nuclear fusion materials. ADVS, 12(20), 2417659. (www)

  @article{ , abstract = {Refractory High-Entropy Alloys (RHEAs) are promising candidates for structural materials in nuclear fusion reactors, where W-based alloys are currently leading. Fusion materials must withstand extreme conditions, including i) severe radiation damage from energetic neutrons, ii) embrittlement due to H and He ion implantation, and iii) exposure to high temperatures and thermal gradients. Recent RHEAs, such as WTaCrV and WTaCrVHf, have shown superior radiation tolerance and microstructural stability compared to pure W, but their multi-element compositions complicate bulk fabrication and limit practical use. In this study, it is demonstrated that reducing alloying elements in RHEAs is feasible without compromising radiation tolerance. Herein, two Highly Concentrated Refractory Alloys (HCRAs) − W 53 Ta 44 V 3 and W 53 Ta 42 V 5 (at.%) − were synthesized and investigated. We found that small V additions significantly influence the radiation response of the binary W–Ta system. Experimental results, supported by ab-initio Monte Carlo simulations and machine-learning-driven molecular dynamics, reveal that minor variations in V content enhance Ta–V chemical short-range order (CSRO), improving radiation resistance in the W 53 Ta 42 V 5 HCRA. By focusing on reducing chemical complexity and the number of alloying elements, the conventional high-entropy alloy paradigm is challenged, suggesting a new approach to designing simplified multi-component alloys with refractory properties for thermonuclear fusion applications.}, archive = {J_ADVS}, author = {Matheus A. Tunes and Darren Parkison and Bochuan Sun and Patrick Willenshofer and Sebastian Samberger and Christoph Frühwirth and Shalini Tripathi and Benjamin K. Derby and Jon Kevin S. Baldwin and Saryu J. Fensin and Damian Sobieraj and Jan S. Wróbel and Jesper Byggmästar and Stefan Pogatscher and Enrique Martinez and Duc Nguyen-Manh and Osman El-Atwani}, doi = {10.1002/advs.202417659}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2417659}, shortjournal = {Adv. Sci.}, title = {High radiation resistance in the binary W-ta system through small v additions: A new paradigm for nuclear fusion materials}, volume = {12}, year = {2025}, }
• (2025). Tunable polariton rabi oscillation in phase-changing perovskite microcavities. ADVS, 12(20), 2417596. (www)

  @article{ , abstract = {Exciton-polaritons are composite quasiparticles hybridized between excitons and photons, which are very promising to develop quantum information devices such as entangled photon pair sources and polariton qubit devices by utilizing the fascinating properties of strong nonlinearity, Bose-Einstein condensation, and superfluidity. Organic–inorganic hybrid lead halide perovskites have attracted much interest in cavity quantum electrodynamics due to their excellent excitonic properties, including strong exciton binding energy and high oscillation strength. Here, tunable Rabi oscillation of exciton-polaritons in the lead halide perovskite microcavity is demonstrated, which experiences a phase transition between orthorhombic, tetragonal, and cubic phases by varying the temperature. Over the phase transition, the Rabi frequency is probed by tracing the dispersion relation of the exciton-polaritons using Fourier plane spectroscopy. Due to the emergence of ferroelectricity in the tetragonal phase of the perovskites, the Rabi splitting can be tuned by ≈20%, while the corresponding exciton oscillator strength is varied by ≈44%. These results provide insight into novel functionalities of polariton devices by utilizing ferroic semiconductors, which can facilitate the development of tunable quantum devices.}, archive = {J_ADVS}, author = {Hyeon-Seo Choi and Minjee Ko and Taejin Lee and Jin-Woo Jung and Young-Jun Lee and Hyeonjong Jeong and Youngjae Kim and Dongha Kim and Jinhee Heo and Shinbuhm Lee and JaeDong Lee and Chang-Hee Cho}, doi = {10.1002/advs.202417596}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2417596}, shortjournal = {Adv. Sci.}, title = {Tunable polariton rabi oscillation in phase-changing perovskite microcavities}, volume = {12}, year = {2025}, }
• (2025). AI-driven TENGs for self-powered smart sensors and intelligent devices. ADVS, 12(20), 2417414. (www)

  @article{ , abstract = {Triboelectric nanogenerators (TENGs) are emerging as transformative technologies for sustainable energy harvesting and precision sensing, offering eco-friendly power generation from mechanical motion. They harness mechanical energy while enabling self-sustaining sensing for self-powered devices. However, challenges such as material optimization, fabrication techniques, design strategies, and output stability must be addressed to fully realize their practical potential. Artificial intelligence (AI), with its capabilities in advanced data analysis, pattern recognition, and adaptive responses, is revolutionizing fields like healthcare, industrial automation, and smart infrastructure. When integrated with TENGs, AI can overcome current limitations by enhancing output, stability, and adaptability. This review explores the synergistic potential of AI-driven TENG systems, from optimizing materials and fabrication to embedding machine learning and deep learning algorithms for intelligent real-time sensing. These advancements enable improved energy harvesting, predictive maintenance, and dynamic performance optimization, making TENGs more practical across industries. The review also identifies key challenges and future research directions, including the development of low-power AI algorithms, sustainable materials, hybrid energy systems, and robust security protocols for AI-enhanced TENG solutions.}, archive = {J_ADVS}, author = {Aiswarya Baburaj and Syamini Jayadevan and Akshaya Kumar Aliyana and Naveen Kumar SK and George K Stylios}, doi = {10.1002/advs.202417414}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2417414}, shortjournal = {Adv. Sci.}, title = {AI-driven TENGs for self-powered smart sensors and intelligent devices}, volume = {12}, year = {2025}, }
• (2025). Correction to “Green light-triggered intraocular drug release for intravenous chemotherapy of retinoblastoma”. ADVS, 12(20), 2416708. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202416708}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2416708}, shortjournal = {Adv. Sci.}, title = {Correction to “Green light-triggered intraocular drug release for intravenous chemotherapy of retinoblastoma”}, volume = {12}, year = {2025}, }
• (2025). Silicon carbide photonic crystal photoelectrode. ADVS, 12(20), 2415552. (www)

  @article{ , abstract = {The immense challenge of large-scale implementation of photoelectrochemical (PEC) water splitting and carbon fixation lies in the need for a cheap, durable, and efficacious photocatalyst. Cubic silicon carbide (3C-SiC) holds compelling potential due to its auspicious band positions and high-volume, high-quality, single crystal industrial manufacturing, but is hindered by its inferior light absorptivity and anodic instability. A slanted parabolic pore photonic crystal (spbPore PC) architecture with graphitic carbon nitride (g-CN), nickel(II) oxide (NiO), or 6H silicon carbide protective coatings is proposed to overcome the drawbacks of 3C-SiC photoelectrodes. A 30 µm- and 62 µm-thick 3C-SiC spbPore PC of lattice constant 0.8 µm demonstrates maximum achievable photocurrent density (MAPD) of 9.95 and 11.53 mA cm −2 in the [280.5, 600] nm region, respectively, representing 75.7% and 87.7% of the total available solar photocurrent density in this spectral range. A 50 nm-thick g-CN or NiO coating forms type-II heterojunctions with the 3C-SiC spbPore PC, facilitating the charge transport and enhancing the corrosion resistivity, all together demonstrating the MAPD of 9.81 and 10.06 mA cm −2 , respectively, for 30 µm-thick PC. The scheme advances the low-cost, sustainable, real-world deployment of PEC cells for green solar fuel production.}, archive = {J_ADVS}, author = {Xiwen Zhang and Sajeev John}, doi = {10.1002/advs.202415552}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2415552}, shortjournal = {Adv. Sci.}, title = {Silicon carbide photonic crystal photoelectrode}, volume = {12}, year = {2025}, }
• (2025). Laser-enabled fabrication of flexible printed electronics with integrated functional devices. ADVS, 12(20), 2415272. (www)

  @article{ , abstract = {The demand for flexible and printed electronics in wearable and soft robotics applications has increased the need for scalable, additive manufacturing processes. However, traditional printed circuit board manufacturing involves complex, multistep processes, is limited to certain substrates, and faces challenges in integrating functional devices. Here, an additive, laser-enabled process is introduced for fabricating flexible, double-sided printed electronics leveraging laser-induced graphene (LIG) as a seed layer for selective copper electrodeposition (E-LIG). This technique enables precise conductive circuit patterning down to 50 µm and is reliable via formation in a single streamlined process. E-LIG supports transfer to various substrates, allowing for large-area electronics up to 100 cm 2 , broadening applications in large-scale interfaces. Functional LIG device integration, including sensors and actuators, directly interfaced with control circuits on a single substrate is demonstrated. Applications such as real-time graphical output and interactive interfacing showcase the method's versatility. E-LIG exhibits repairability for on-demand restoration of damaged circuits, enhancing durability and offering a scalable, cost-effective solution for multifunctional printed electronics.}, archive = {J_ADVS}, author = {Wedyan Babatain and Christine Park and Hiroshi Ishii and Neil Gershenfeld}, doi = {10.1002/advs.202415272}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2415272}, shortjournal = {Adv. Sci.}, title = {Laser-enabled fabrication of flexible printed electronics with integrated functional devices}, volume = {12}, year = {2025}, }
• (2025). Transcriptome landscape of cancer-associated fibroblasts in human PDAC. ADVS, 12(20), 2415196. (www)

  @article{ , abstract = {Cancer-associated fibroblasts (CAFs) play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). Here, integrated single-cell RNA sequencing analysis is utilized to comprehensively map CAFs in the human PDAC tumor microenvironment (TME). Normal fibroblasts (NFs) and nine distinct CAF subtypes are identified including newly identified CAF subtypes, CDCP1 + FTL + CAFs, transitional CAFs (tCAFs), interferon simulated genes (ISG) + myofibroblastic CAFs (myCAFs), and proliferative CAFs (pCAFs). CDCP1 + FTL + CAFs, pCAFs, and ISG + myCAFs are associated with unfavorable clinical outcomes. CDCP1 + FTL + CAFs exhibit enhanced glycolysis and iron metabolism, resisting ferroptosis. The antigen-presenting CAFs (apCAFs) show high heterogeneity, consisting of multiple subtypes expressing distinct immune cell signatures. The CAF subtypes display differentiation plasticity, transitioning from early normal-like CAFs (nCAFs) to inflammatory CAFs (iCAFs) and myCAFs, ultimately leading to more invasive pCAFs. AP-1 family members FOS and JUN regulate the malignant phenotype conversion of NFs to nCAFs, while transforming growth factor-β (TGFβ) and interferon-γ (IFNγ) signals trigger the interconversion between classic myCAFs and iCAFs, respectively. A close interaction between CAFs and myeloid cells (especially neutrophils) is further observed in PDAC-TME, mainly mediated by CXCR4-CXCL12 chemotaxis. This work depicts a detailed CAF map and its dynamic interconvertible shift, providing important insights for combined targeted CAFs therapy.}, archive = {J_ADVS}, author = {Mengyu Tao and Wenting Liu and Jianhua Chen and Rujiao Liu and Jianling Zou and Bo Yu and Chenchen Wang and Mingzhu Huang and Qingjian Chen and Zhe Zhang and Zhiyu Chen and Haoyu Sun and Cheng Zhou and Shuguang Tan and Yuxuan Zheng and Hongxia Wang}, doi = {10.1002/advs.202415196}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2415196}, shortjournal = {Adv. Sci.}, title = {Transcriptome landscape of cancer-associated fibroblasts in human PDAC}, volume = {12}, year = {2025}, }
• (2025). Catheter injectable multifunctional biomaterial for the treatment of infected enterocutaneous fistulas. ADVS, 12(20), 2414642. (www)

  @article{ , abstract = {Enterocutaneous fistulas (ECF) are challenging to treat contributing to high morbidity and high mortality rates, significantly impacting the quality of life of the patients. Its susceptibility to antibiotic-resistant infections often leads to chronic inflammation, complicating treatment with conventional methods. Here, 18NC75-10P-1IL is reported, which is a multi-functional shear-thinning hydrogel comprised of gelatin and nanosilicates for injectability, an ionic liquid for bactericidal effects, and platelet rich fibrin fraction for pro-healing properties; this biomaterial is engineered for the treatment of ECFs. Through rigorous testing, the mechanical properties of 18NC75-10P-1IL were tailored for catheter injection to achieve durable occlusion of fistulous tracts under external pressures simulating clinical scenarios. 18NC75-10P-1IL demonstrated pro-healing effects and anti-microbial activity against highly resistant patient-derived bacteria known to be associated with ECF. Subcutaneous implantation and anorectal fistula models confirmed its biocompatibility, pro-healing, anti-inflammatory, and anti-microbial properties compared to control materials, suggesting promising potential for clinical translation in the treatment of human ECFs.}, archive = {J_ADVS}, author = {Jinjoo Kim and Zefu Zhang and Hassan Albadawi and Hyeongseop Keum and Joseph L. Mayer and Erin H. Graf and Rahmi Oklu}, doi = {10.1002/advs.202414642}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2414642}, shortjournal = {Adv. Sci.}, title = {Catheter injectable multifunctional biomaterial for the treatment of infected enterocutaneous fistulas}, volume = {12}, year = {2025}, }
• (2025). The semi-natural climate chambers across latitudes: A broadly applicable husbandry and experimental system for terrestrial ectotherms under climate change. ADVS, 12(20), 2414185. (www)

  @article{ , abstract = {With limited resources and efforts, assessing species' vulnerabilities across various geographic regions before the conservation practice is essential for biodiversity conservation in the context of climate change. One pressing challenge has been establishing natural temperature-manipulated research systems across latitudes. To address this challenge, an innovative infrastructure is developed named the semi-natural climate chambers across latitudes (SCCAL), consisting of semi-natural climate chambers at three latitudes, spanning 27° and 3393 km from tropical to temperate regions. Each latitude features eight medium-sized patches for temperature manipulation, organisms rearing, and ecological experiments. Independent of external water and electricity supplies, the SCCAL allows to simulate thermal environments under different climate change scenarios with natural soil moisture. Ecological experiments with Grass lizards successfully are conducted, demonstrating that the SCCAL effectively supports species rearing, responses determining, and the vulnerability assessing. The widespread adoption or development of similar infrastructures is encouraged, which can facilitate the assessment of latitudinal animal vulnerabilities under climate change.}, archive = {J_ADVS}, author = {Bao-Jun Sun and Hong-Liang Lu and Kun-Ming Cheng and Wan-Li Liu and Xing-Zhi Han and Luo-Xin Cui and Xing-Han Li and Shu-Ran Li and Xin Hao and Fan Li and Dan-Yang Wu and Teng Li and Yong-Pu Zhang and Ji-Chao Wang and Peng Liu and Wei-Guo Du}, doi = {10.1002/advs.202414185}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2414185}, shortjournal = {Adv. Sci.}, title = {The semi-natural climate chambers across latitudes: A broadly applicable husbandry and experimental system for terrestrial ectotherms under climate change}, volume = {12}, year = {2025}, }
• (2025). UGDH lactylation aggravates osteoarthritis by suppressing glycosaminoglycan synthesis and orchestrating nucleocytoplasmic transport to activate MAPK signaling. ADVS, 12(20), 2413709. (www)

  @article{ , abstract = {Osteoarthritis (OA) progression is closely related to dysregulated glycolysis. As the primary metabolite of glycolysis, lactate plays a detrimental role in OA. However, how lactate exacerbates OA process remains unclear. Here, this study revealed that lactate levels are elevated in the synovial fluid of OA patients and IL-1β-treated human primary chondrocytes, promoting protein pan-lactylation. Functionally, hyper-lactylation exacerbates chondrocytes extracellular matrix (ECM) degradation and cell apoptosis in vitro and in vivo. Moreover, UDP-glucose dehydrogenase (UGDH) is proven to be the key lactylated protein in lactate-treated chondrocytes, which undergoes lactylation at lysine 6 (K6). Lactylated UGDH repressed its enzymatic activity, reducing glycosaminoglycan synthesis and disregulating its nuclear-cytoplasmic distribution. Mechanistically, K6 lactylation of UGDH impedes the interaction of UGDH and signal transducer and activator of transcription 1 (STAT1), thus promoting the transcription of mitogen-activated protein kinase kinase kinase 8 (MAP3K8) and activating the MAPK signaling pathway. Importantly, in vitro and in vivo treatment with A485, a specific acyltransferase P300 inhibitor, suppressed UGDH lactylation and rescued chondrocytes ECM degradation and OA progression. These findings uncover a new mechanism underlying OA pathogenesis and highlight the potential of targeting UGDH lactylation as a novel therapeutic strategy for OA.}, archive = {J_ADVS}, author = {Weiren Lan and Xueman Chen and Huai Yu and Jianzhao Ruan and Jingliang Kang and Xiaoyu Nie and Yumei Cao and Su'an Tang and Changhai Ding}, doi = {10.1002/advs.202413709}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413709}, shortjournal = {Adv. Sci.}, title = {UGDH lactylation aggravates osteoarthritis by suppressing glycosaminoglycan synthesis and orchestrating nucleocytoplasmic transport to activate MAPK signaling}, volume = {12}, year = {2025}, }
• (2025). NKX2-5/LHX1 and UHRF1 establishing a positive feedback regulatory circuitry drives esophageal squamous cell carcinoma through epigenetic dysregulation. ADVS, 12(20), 2413508. (www)

  @article{ , abstract = {DNA methylation regulators play critical roles in modulating oncogenic driver genes in cancers. However, the precise mechanisms through which these DNA methylation regulators influence oncogenesis and clinical therapy have yet to be fully elucidated. This study reveals that hypermethylation of under-methylated regions (UMRs) within gene bodies is involved in the activation of oncogenic homeobox genes, particularly NKX2-5 and LHX1, in esophageal squamous cell carcinoma (ESCC). Mechanistically, NKX2-5 and LHX1 synergistically bind to the promoter region of UHRF1 , thereby augmenting its transcription. In turn, UHRF1 orchestrates the recruitment of DNMT1/DNMT3A, alongside NKX2-5 and LHX1, to the UMRs of these genes, thereby increasing DNA methylation levels and their expression. This intricate interplay forms a positive transcriptional feedback loop between NKX2-5/LHX1 and UHRF1, thus promoting the overexpression of all three genes and ultimately facilitating tumor growth. Notably, concurrent inhibition of UHRF1 and DNMTs impedes tumor growth by suppressing NKX2-5 and LHX1 expression. Overall, this study identifies a positive feedback regulatory circuitry underlying the UMR hypermethylation-mediated activation of oncogenic drivers in ESCC and proposes a promising therapeutic strategy for ESCC patients.}, archive = {J_ADVS}, author = {Xukun Li and Dandan Fan and Yong Li and Jian Yuan and Wanyuan Sun and Qinghao Zhu and Ling Qi and Xueling Wu and Jiahui Cai and Tongyang Gong and Ning Zhao and Jianzhong Su and Zhihua Liu and Hongyan Chen}, doi = {10.1002/advs.202413508}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413508}, shortjournal = {Adv. Sci.}, title = {NKX2-5/LHX1 and UHRF1 establishing a positive feedback regulatory circuitry drives esophageal squamous cell carcinoma through epigenetic dysregulation}, volume = {12}, year = {2025}, }
• (2025). An Agrin–YAP/TAZ rigidity sensing module drives EGFR-addicted lung tumorigenesis. ADVS, 12(20), 2413443. (www)

  @article{ , abstract = {Despite epidermal growth factor receptor (EGFR) is a pivotal oncogene for several cancers, including lung adenocarcinoma (LUAD), how it senses extracellular matrix (ECM) rigidity remain elusive in the context of the increasing role of tissue rigidity on various hallmarks of cancer development. Here it is shown that EGFR dictates tumorigenic agrin expression in lung cancer cell lines, genetically engineered EGFR-driven mouse models, and human specimens. Agrin expression confers substrate stiffness-dependent oncogenic attributes to EGFR-reliant cancer cells. Mechanistically, agrin mechanoactivates EGFR through epidermal growth factor (EGF)-dependent and independent modes, thereby sensitizing its activity toward localized cancer cell-ECM adherence and bulk rigidity by fostering interactions with integrin β1. Notably, a feed-forward loop linking agrin–EGFR rigidity response to YAP–TEAD mechanosensing is essential for tumorigenesis. Together, the combined inhibition of EGFR–YAP/TEAD may offer a strategy to reduce lung tumorigenesis by disrupting agrin-EGFR mechanotransduction, uncovering a therapeutic vulnerability for EGFR-addicted lung cancers.}, archive = {J_ADVS}, author = {Reza Bayat Mokhtari and Divyaleka Sampath and Paige Eversole and Melissa Ong Yu Lin and Dmitriy A. Bosykh and Gandhi T.K. Boopathy and Aravind Sivakumar and Cheng-Chun Wang and Ramesh Kumar and Joe Yeong Poh Sheng and Ellen Karasik and Barbara A. Foster and Han Yu and Xiang Ling and Wenjie Wu and Fengzhi Li and Zoë Weaver Ohler and Christine F. Brainson and David W. Goodrich and Wanjin Hong and Sayan Chakraborty}, doi = {10.1002/advs.202413443}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413443}, shortjournal = {Adv. Sci.}, title = {An Agrin–YAP/TAZ rigidity sensing module drives EGFR-addicted lung tumorigenesis}, volume = {12}, year = {2025}, }
• (2025). PPY-induced iCAFs cultivate an immunosuppressive microenvironment in pancreatic cancer. ADVS, 12(20), 2413432. (www)

  @article{ , abstract = {Pancreatic ductal adenocarcinoma (PDAC) is characterized by cancer cells surrounded by affluent stromal components, which may underlie their limited response to various therapeutic interventions, including immunotherapy. Inflammatory cancer-associated fibroblasts (iCAFs), a crucial subset of CAFs within the PDAC microenvironment, play a pivotal role in shaping an immunosuppressive microenvironment. In this study, single-cell RNA sequencing analysis is performed to screen for cancer cells-secreted proteins associated with iCAF induction, and PPY (pancreatic polypeptide) is validated as a potent inducer. Unlike previously reported iCAF inducers, PPY is a gastrointestinal hormone predominantly expressed in the pancreas, suggesting that targeting it may have minimal systemic effects. Multiplex immunohistochemistry (mIHC) on human PDAC tissue microarrays, orthotopic allograft mouse models, and co-culture experiments are utilized to validate the crucial role of PPY in iCAF induction. Mechanistic studies integrating mRNA sequencing, immunoprecipitation-mass spectrometry, and molecular docking reveal that PPY induces iCAFs by activating the non-canonical NF-κB pathway through EGFR. Importantly, targeting PPY enhanced the efficacy of anti-PD-1 immunotherapy in KPC ( Kras LSL-G12D/+ ; Trp53 LSL-R172H/+ ; Pdx1 -Cre) mice, as evidenced by reduced tumor burden on PET-CT imaging and improved survival. This research is expected to provide a novel strategy for improving immunotherapy in PDAC by targeting a key inducer of iCAFs.}, archive = {J_ADVS}, author = {Mengdie Cao and Wang Peng and Bin Cheng and Ronghua Wang and Wei Chen and Luyao Liu and Hai Huang and Shiru Chen and Haochen Cui and JingWen Liang and Qiaodan Zhou and Si Xiong and Shuya Bai and Luoxia Liu and Yuchong Zhao}, doi = {10.1002/advs.202413432}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413432}, shortjournal = {Adv. Sci.}, title = {PPY-induced iCAFs cultivate an immunosuppressive microenvironment in pancreatic cancer}, volume = {12}, year = {2025}, }
• (2025). Serrated leaf-like N-doped copper sulfide enabling bifunctional oxygen Reduction/Evolution via dual-mode cathode reactions for high energy density and cycle stability in Zinc–Air batteries. ADVS, 12(20), 2413425. (www)

  @article{ , abstract = {Zinc–air batteries (ZABs) are promising electrochemical energy storages, but inefficient oxygen reduction reaction (ORR) during discharging and oxygen evolution reaction (OER) during charging at their cathodes impede achieving high energy density and stable cycling. We report a serrated leaf-like nitrogen-doped copper sulfide (N-CuS) cathode with conductive N 2p-S 3p hybridized orbitals, oxygen-transporting mesopores, and about fivefold larger surface area than Cu. A ZAB with the N-CuS cathode exhibits a 788 mAh g −1 capacity (96% of theoretical) and a hitherto highest energy density of 916.0 Wh kg −1 , surpassing one with the state-of-the-art Pt/C+RuO₂ cathode (712.43 mAh g −1 and 874 Wh kg −1 ). Density functional theory calculations elucidate that O═O bond dissociation is 0.97 eV more favorable on N-CuS than CuS. Subsequently, protonation of surface-adsorbed *O to *OH occurs via dissociate (0.55 V), non-spit associate (1.05 V), and split associate (1.05 V) pathways, with *OH then desorbing as OH - . Under anaerobic conditions, copper oxide transitions from CuO to Cu 2 O (1.05 V) and eventually to Cu (0.75 V) releasing oxygen to sustain ORR. Additionally, a ZAB with the N-CuS cathode achieves about threefold longer cyclability than one with the Pt/C+IrO₂ cathode, and about six-fold longer cyclability than one with the Pt/C+RuO₂ cathode.}, archive = {J_ADVS}, author = {Do Hwan Jung and Yong Hak Park and Dong Won Kim and Jong Hui Choi and Seungrae Cho and Keon-Han Kim and Dong Gyu Park and Byungchan Han and Jeung Ku Kang}, doi = {10.1002/advs.202413425}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413425}, shortjournal = {Adv. Sci.}, title = {Serrated leaf-like N-doped copper sulfide enabling bifunctional oxygen Reduction/Evolution via dual-mode cathode reactions for high energy density and cycle stability in Zinc–Air batteries}, volume = {12}, year = {2025}, }
• (2025). Verteporfin-mediated in situ nanovaccine based on local conventional-dose hypofractionated radiotherapy enhances antitumor and immunomodulatory effect. ADVS, 12(20), 2413387. (www)

  @article{ , abstract = {In situ radiotherapy is the most successful cytotoxic therapy available for the treatment of solid tumors, while high-dose radiotherapy per fraction is not yet widely and reliably used. To some extent, the major considerations of the disappointing results are on the risk of high-dose irradiation-induced damage to the surrounding normal tissues and the difficulty in distant metastasis control. To break these restraints, a gelatinase-responsive amphiphilic methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP), a special photosensitizer that can also be excited by X-rays to produce cytotoxic singlet oxygen and greatly enhance radiotherapy efficacy, is prepared in this study. Herein, it is shown that the formed N@VP combined with conventional-dose radiation therapy (RT, 2 Gy (gray, a radiation dose unit)) can realize an antitumor effect no less than high-dose RT (8 Gy) and minimize radiation dose necessary to achieve local tumor control. Moreover, this radiosensitive nanosystem can exert excellent systemic antitumor immunity and abscopal effect, providing a preferable “in situ vaccine” strategy based on conventional-dose RT to achieve efficient systemic management of distant tumor metastasis. When combined with immunotherapy, this novel strategy for radiosensitization results in better immunotherapy sensitivity by stimulating significant immunogenic tumor cell death and synergistic antitumor immune responses.}, archive = {J_ADVS}, author = {Zhifan Zhang and Lin Li and Yuchen Ge and Anni Chen and Shanchao Diao and Yueling Yang and Qianyue Chen and Yingling Zhou and Jie Shao and Fanyan Meng and Lixia Yu and Manman Tian and Xiaoping Qian and Zhaoyu Lin and Chen Xie and Baorui Liu and Rutian Li}, doi = {10.1002/advs.202413387}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413387}, shortjournal = {Adv. Sci.}, title = {Verteporfin-mediated in situ nanovaccine based on local conventional-dose hypofractionated radiotherapy enhances antitumor and immunomodulatory effect}, volume = {12}, year = {2025}, }
• (2025). Massage-mimicking nanosheets mechanically reorganize inter-organelle contacts to restore mitochondrial functions in parkinson's disease. ADVS, 12(20), 2413376. (www)

  @article{ , abstract = {Parkinson's disease (PD) is exacerbated by dysfunction of inter-organelle contact, which depends on cellular responses to the mechanical microenvironment and can be regulated by external mechanical forces. Delivering dynamic mechanical forces to neural cells proves challenging due to the skull. Inspired by the effects of massage; here PEGylated black phosphorus nanosheets (PEG-BPNS), known for their excellent biocompatibility, biodegradability, specific surface area, mechanical strength, and flexibility, are introduced, which are capable of adhering to neural cell membrane and generating mechanical stimulation with their lateral size of 200 nm, exhibiting therapeutic potential in a 1-methyl-4-phenyl-1,2,3,6-te-trahydropyridine-induced PD mouse model by regulating inter-organelle contacts. Specifically, it is found that 200 nm PEG-BPNS, acting as “NanoMassage,” significantly increase  plasma membrane tension, as evidenced by fluorescent lipid tension reporter fluorescence lifetime analysis. This mechanical force modulates actin reorganization, subsequently regulating the contacts between actin, mitochondria, and endoplasmic reticulum, further controlling mitochondrial fission and mitigating mitochondrial dysfunction in PD, exhibiting therapeutic efficacy via intranasal administration. These findings provide a noninvasive strategy for applying mechanical stimulation to deep brain areas and elucidate the mechanism of NanoMassage mediating inter-organelle contacts, suggesting the rational design of “NanoMassage” to remodel inter-organelle communications in neurodegenerative disease treatment.}, archive = {J_ADVS}, author = {Tianqi Li and Liwen Huang and Chenxiao Guo and Jing Ren and Xi Chen and Yachu Ke and Zengyu Xun and Wenzhuo Hu and Yilin Qi and Heping Wang and Zhongying Gong and Xing-Jie Liang and Xue Xue}, doi = {10.1002/advs.202413376}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413376}, shortjournal = {Adv. Sci.}, title = {Massage-mimicking nanosheets mechanically reorganize inter-organelle contacts to restore mitochondrial functions in parkinson's disease}, volume = {12}, year = {2025}, }
• (2025). FREQ-NESS reveals the dynamic reconfiguration of frequency-resolved brain networks during auditory stimulation. ADVS, 12(20), 2413195. (www)

  @article{ , abstract = {The brain is a dynamic system whose network organization is often studied by focusing on specific frequency bands or anatomical regions, leading to fragmented insights, or by employing complex and elaborate methods that hinder straightforward interpretations. To address this issue, a new analytical pipeline named FREQuency-resolved Network Estimation via Source Separation (FREQ-NESS) is introduced. This pipeline is designed to estimate the activation and spatial configuration of simultaneous brain networks across frequencies by analyzing the frequency-resolved multivariate covariance between whole-brain voxel time series. In this study, FREQ-NESS is applied to source-reconstructed magnetoencephalography (MEG) data during resting state and isochronous auditory stimulation. Our results reveal simultaneous, frequency-specific brain networks during resting state, such as the default mode, alpha-band, and motor-beta networks. During auditory stimulation, FREQ-NESS detects: 1) emergence of networks attuned to the stimulation frequency, 2) spatial reorganization of existing networks, such as alpha-band networks shifting from occipital to sensorimotor areas, 3) stability of networks unaffected by auditory stimuli. Furthermore, auditory stimulation significantly enhances cross-frequency coupling, with the phase of auditory networks attuned to the stimulation modulating gamma band amplitude in medial temporal lobe networks. In conclusion, FREQ-NESS effectively maps the brain's spatiotemporal dynamics, providing a comprehensive view of brain function by revealing a landscape of simultaneous, frequency-resolved networks and their interaction.}, archive = {J_ADVS}, author = {Mattia Rosso and Gemma Fernández-Rubio and Peter Erik Keller and Elvira Brattico and Peter Vuust and Morten L Kringelbach and Leonardo Bonetti}, doi = {10.1002/advs.202413195}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413195}, shortjournal = {Adv. Sci.}, title = {FREQ-NESS reveals the dynamic reconfiguration of frequency-resolved brain networks during auditory stimulation}, volume = {12}, year = {2025}, }
• (2025). A compound screen based on isogenic hESC-derived β cell reveals an inhibitor targeting ZnT8-mediated zinc transportation to protect pancreatic β cell from stress-induced cell death. ADVS, 12(20), 2413161. (www)

  @article{ , abstract = {Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. Nevertheless, the fundamental mechanism of cellular stress regulation remains elusive. Here, it is found that elevated zinc transportation causes excessive cellular stress in pancreatic β cells in diabetes. With gene-edited human embryonic stem cell-derived β cells (SC-β cells) and human primary islets, the results reveal that elevated zinc transportation initiates the integrated stress response (ISR), and ultimately leads to β cell death. By contrary, genetic abolishment of zinc transportation shields β cells from exacerbated endoplasmic reticulum stress (ER stress) and concurrent ISR. To target excessive zinc transportation with a chemical inhibitor, an isogenic SC-β cells based drug-screening platform is established. Surprisingly, independent of its traditional role as protein synthesis inhibitor at a high-dose (10 µ m ), low-dose (25 n m ) anisomycin significantly inhibits zinc transportation and effectively prevents β cell loss. Remarkably, in vivo administration of anisomycin in mice demonstrates protective effects on β cells and prevents type 2 diabetes induced by high-fat diet. Overall, elevated zinc transportation is identified as a crucial driver of β cell loss and low-dose anisomycin as a potential therapeutic molecule for diabetes.}, archive = {J_ADVS}, author = {Rui Hu and Qing Ma and Yunhui Kong and Zhaoyue Wang and Minglu Xu and Xiangyi Chen and Yajuan Su and Tinghui Xiao and Qing He and Xuan Wang and Wenjun Xu and Yiling Yang and Xushu Wang and Xiaobo Li and Yanfang Liu and Shuangshuang Chen and Rui Zhao and Meng Guo and Gaowei Wang and Weida Li}, doi = {10.1002/advs.202413161}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413161}, shortjournal = {Adv. Sci.}, title = {A compound screen based on isogenic hESC-derived β cell reveals an inhibitor targeting ZnT8-mediated zinc transportation to protect pancreatic β cell from stress-induced cell death}, volume = {12}, year = {2025}, }
• (2025). Transformative 3D printing of carbon-metal nanocomposites as catalytic joule heaters for enhanced ammonia decomposition. ADVS, 12(20), 2413149. (www)

  @article{ , abstract = {Electrified thermal chemical synthesis plays a critical role in reducing energy consumption and enabling the industrial decarbonization. While Joule heating offers a promising alternative to gas-burning furnace systems by directly heating substrates via renewable energy supply, most approaches can only heat the reactor, not the catalytic sites. This limitation stems from the lack of methods to on-demand create Joule heaters containing in situ loaded catalytic nanoparticles. This work introduces a scalable platform for producing carbonaceous Joule heaters embedded with catalytic nanoparticles from 3D-printed polypropylene precursors, prepared through crosslinking, metal nitration immersion, and pyrolysis steps. Specifically, sulfonate groups on crosslinked PP can bind with metal ions, yielding well-dispersed, nanosized particles within a carbon structure that maintains macroscopic dimensional accuracy throughout the manufacturing. The approach is modular, allowing control over particle size and composition. Structured carbon with in situ loaded nickel nanoparticles demonstrates efficient Joule heating, high catalytic activity, and significantly reduced activation energy for catalytic ammonia decomposition. This work provides an innovative material and manufacturing platform to produce structured, catalytically active Joule heaters for decarbonization of chemical synthesis and energy production.}, archive = {J_ADVS}, author = {Paul Smith and Jiachun Wu and Anthony Griffin and Kaleb Jones and Jeff Aguinaga and Ethan Bounds and Derek Patton and Yizhi Xiang and Zhe Qiang}, doi = {10.1002/advs.202413149}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413149}, shortjournal = {Adv. Sci.}, title = {Transformative 3D printing of carbon-metal nanocomposites as catalytic joule heaters for enhanced ammonia decomposition}, volume = {12}, year = {2025}, }
• (2025). Self-catalyzed chemically coalescing liquid metal emulsions. ADVS, 12(20), 2413116. (www)

  @article{ , abstract = {Gallium-based liquid metal alloys (GaLMAs) have widespread applications ranging from soft electronics, energy devices, and catalysis. GaLMAs can be transformed into liquid metal emulsions (LMEs) to modify their rheology for facile patterning, processing, and material integration for GaLMA-based device fabrication. One drawback of using LMEs is reduced electrical conductivity owing to the oxides that form on the surface of dispersed liquid metal droplets. LMEs thus need to be activated by coalescing liquid metal droplets into an electrically conductive network, which usually involves techniques that subject the LME to harsh conditions. This study presents a way to coalesce these droplets through a chemical reaction at mild temperatures ( T ∼ 80 °C). Chemical activation is enabled by adding halide compounds into the emulsion that chemically etch the oxide skin on the surface of dispersed droplets of eutectic gallium indium (eGaIn). LMEs synthesized with halide activators can achieve electrical conductivities close to bulk liquid metal (2.4 × 10 4 S cm −1 ) after being heated. 3D printable chemically coalescing LME ink formulations are optimized by systematically exploring halide activator type and concentration, along with mixing conditions, while maximizing for electrical conductivity, shape retention, and compatibility with direct ink writing (DIW). The utility of this ink is demonstrated in a hybrid 3D printing process to create a battery-integrated light emitting diode array, followed by a nondestructive low temperature heat activation that produces a functional device.}, archive = {J_ADVS}, author = {Stephanie F. Zopf and Ramón E. Sánchez Cruz and Chloe Kekedjian and Lu Ping and Javier M. Morales Ferrer and Jean Paul Soto Aquino and Rongxuan Xie and Xi Ling and J. William Boley}, doi = {10.1002/advs.202413116}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413116}, shortjournal = {Adv. Sci.}, title = {Self-catalyzed chemically coalescing liquid metal emulsions}, volume = {12}, year = {2025}, }
• (2025). Lactylation-driven NUPR1 promotes immunosuppression of tumor-infiltrating macrophages in hepatocellular carcinoma. ADVS, 12(20), 2413095. (www)

  @article{ , abstract = {While checkpoint immunotherapy effectively mobilizes T-cell responses against tumors, its success in hepatocellular carcinoma (HCC) is frequently undermined by immunosuppressive myeloid cells within the tumor microenvironment. This study investigates the role of nuclear protein 1 (NUPR1), a gene prominently expressed in tumor-associated macrophages (TAMs), in mediating this suppression and influencing immunotherapy outcomes. Through comprehensive analysis of single-cell RNA sequencing (scRNA-seq) datasets and functional assays in vitro and in vivo, NUPR1 is identified as a critical regulator within TAMs. The upregulation of NUPR1 is associated with enhanced M2 macrophage polarization and increased expression of immune checkpoints PD-L1 and SIRPA, resulting in CD8+ T cell exhaustion and a diminished response to immunotherapy. Mechanistically, NUPR1 inhibits the ERK and JNK signaling pathways, thereby creating an immunosuppressive milieu conducive to tumor progression. Additionally, tumor-derived lactate is shown to upregulate NUPR1 expression in macrophages via histone lactylation, perpetuating a feedback loop that intensifies immune suppression. Pharmacological targeting of NUPR1 reverses M2 polarization, curtails tumor growth, and augments the efficacy of PD-1 blockade in preclinical models, positioning NUPR1 as both a potential biomarker for immunotherapy responsiveness and a therapeutic target to boost immunotherapy efficacy in HCC.}, archive = {J_ADVS}, author = {Jialiang Cai and Peiling Zhang and Yufan Cai and Guiqi Zhu and Shiping Chen and Lina Song and Junxian Du and Biao Wang and Weixing Dai and Jian Zhou and Jia Fan and Yiyi Yu and Zhi Dai}, doi = {10.1002/advs.202413095}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413095}, shortjournal = {Adv. Sci.}, title = {Lactylation-driven NUPR1 promotes immunosuppression of tumor-infiltrating macrophages in hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Chemical vapor deposition strategy of fe-N-C nanotubes for the oxygen evolution reaction. ADVS, 12(20), 2413035. (www)

  @article{ , abstract = {The conversion of metal-nitrogen-carbon (M-N-C) nanoparticles derived from conventional metal-organic frameworks (MOFs) into self-supporting and well-defined metal-nitrogen-carbon (M-N-C) superstructures is essential for various functional applications but remains a significant challenge. In this study, a versatile chemical vapor deposition (CVD) strategy is developed for solvent-free synthesis of self-supporting carbonaceous nanotubes doped with metal and nitrogen (MNCT). The stable carbonaceous nanotubes doped with Fe and N (FeNCT) fabricated here exhibit excellent electrocatalytic performances for the oxygen evolution reaction (OER) and outperform the carbonaceous film doped with Fe and N grown on carbon foil directly (FeNC/CF), which demonstrates the advantages of the superstructure of FeNCT. This strategy also provides a way to tailor the metal-nitrogen-carbon nanotubes (MNCT) catalyst according to the feature of the reactor and exhibits many advantages, such as wide applicability and facile scalability.}, archive = {J_ADVS}, author = {Xin Liu and Tao Wei and Jonas Englhard and Maïssa Barr and Andreas Hirsch and Julien Bachmann}, doi = {10.1002/advs.202413035}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2413035}, shortjournal = {Adv. Sci.}, title = {Chemical vapor deposition strategy of fe-N-C nanotubes for the oxygen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). Icaritin represses autophagy to promote colorectal cancer cell apoptosis and sensitized low-temperature photothermal therapy via targeting HSP90-TXNDC9 interactions. ADVS, 12(20), 2412953. (www)

  @article{ , abstract = {Colorectal cancer (CRC) ranks among the leading causes of cancer-related dea ths worldwide, and the rising incidence and mortality of CRC underscores the urgent need for better understanding and management strategies. Icaritin (ICA) is the metabolites of icariin, a natural flavonoid glycoside compound derived from the stems and leaves of Epimedium . It has broad spectrum antitumor activity and inhibits the proliferation, migration, and invasion of CRC cells, and causes S phase cell cycle arrest. It exerts its antitumor effects against CRC through repressing autophagy to promote CRC cell apoptosis via interfering the HSP90-TXNDC9 interactions. The safety and efficacy of ICA are also affirmed in a mouse xenograft model. Additionally, to test whether ICA exerts synergistic effects with low-temperature photothermal therapy (LTPTT), a novel nanodrug delivery system, employing SiO 2 nanocarriers, is designed aiming to load ICA with photothermal materials polydopamine (PDA), and folic acid (FA). This SiO 2 /Ica-PDA-FA multifunctional nanocomposite actively targets tumor tissues through the high affinity of FA for cancer cells. Once internalized, the acidic intracellular environment triggers the controlled release of ICA, inhibiting HSP90-TXNDC9 interactions. By LTPTT and ICA drug therapy under near-infrared illumination, a dual synergistic antitumor effect is achieved, holding promise for enhancing therapeutic outcomes in CRC treatment.}, archive = {J_ADVS}, author = {Dan He and Siliang Chen and Xiaoyun Wang and Xiang Wen and Changyang Gong and Lei Liu and Gu He}, doi = {10.1002/advs.202412953}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412953}, shortjournal = {Adv. Sci.}, title = {Icaritin represses autophagy to promote colorectal cancer cell apoptosis and sensitized low-temperature photothermal therapy via targeting HSP90-TXNDC9 interactions}, volume = {12}, year = {2025}, }
• (2025). Targeting senescence with apigenin improves chemotherapeutic efficacy and ameliorates age-related conditions in mice. ADVS, 12(20), 2412950. (www)

  @article{ , abstract = {Cellular senescence is a cell fate triggered by stressful stimuli and displays a hypersecretory feature, the senescence-associated secretory phenotype (SASP). Senescent cell burden increases with aging and contributes to age-related organ dysfunction and multiple chronic disorders. In this study, a large scale screening of a natural product library for senotherapeutic candidates is performed. Apigenin, a dietary flavonoid previously reported with antioxidant and anti-inflammatory activities, exhibits capacity for targeting senescent cells as a senomorphic agent. This compound blocks the interactions between ATM/p38MAPK and HSPA8, preventing the transition of an acute stress-associated phenotype (ASAP) toward the SASP. Mechanistically, apigenin targets peroxiredoxin 6 (PRDX6), an intracellular redox-active molecule, suppressing the iPLA2 activity of PRDX6 and disrupting downstream reactions underlying SASP development. Apigenin reduces the severity of cancer cell malignancy promoted by senescent stromal cells in culture, while restraining chemoresistance when combined with chemotherapy in anticancer regimens. In preclinical trials, apigenin improves the physical function of animals with a premature aging-like state, alleviating physical frailty and cognitive impairment. Together, the study demonstrates the feasibility of exploiting a natural compound with senomorphic capacity to achieve geroprotective effects by modulating the SASP, thus providing a baseline for future exploration of natural agents for alleviating age-related conditions.}, archive = {J_ADVS}, author = {Hongwei Zhang and Qixia Xu and Zhirui Jiang and Rong Sun and Qun Wang and Sanhong Liu and Xin Luan and Judith Campisi and James L. Kirkland and Weidong Zhang and Yu Sun}, doi = {10.1002/advs.202412950}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412950}, shortjournal = {Adv. Sci.}, title = {Targeting senescence with apigenin improves chemotherapeutic efficacy and ameliorates age-related conditions in mice}, volume = {12}, year = {2025}, }
• (2025). CPL-diff: A diffusion model for de novo design of functional peptide sequences with fixed length. ADVS, 12(20), 2412926. (www)

  @article{ , abstract = {Peptides are recognized as next-generation therapeutic drugs due to their unique properties and are essential for treating human diseases. In recent years, a number of deep generation models for generating peptides have been proposed and have shown great potential. However, these models cannot well control the length of the generated sequence, while the sequence length has a very important impact on the physical and chemical properties and therapeutic effects of peptides. Here, a diffusion model is introduced, capable of controlling the length of generated functional peptide sequences, named CPL-Diff. CPL-Diff can control the length of generated polypeptide sequences using only attention masking. Additionally, CPL-Diff can generate single-functional polypeptide sequences based on given conditional information. Experiments demonstrate that the peptides generated by CPL-Diff exhibit lower perplexity and similarity compared to those produced by the current state-of-the-art models, and further exhibit relevant physicochemical properties similar to real sequences. The interpretability analysis is also performed on CPL-Diff to understand how it controls the length of generated sequences and the decision-making process involved in generating polypeptide sequences, with the aim of providing important theoretical guidance for polypeptide design. The code for CPL-Diff is available at https://github.com/luozhenjie1997/CPL-Diff .}, archive = {J_ADVS}, author = {Zhenjie Luo and Aoyun Geng and Leyi Wei and Quan Zou and Feifei Cui and Zilong Zhang}, doi = {10.1002/advs.202412926}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412926}, shortjournal = {Adv. Sci.}, title = {CPL-diff: A diffusion model for de novo design of functional peptide sequences with fixed length}, volume = {12}, year = {2025}, }
• (2025). Machine learning-enhanced optimization for high-throughput precision in cellular droplet bioprinting. ADVS, 12(20), 2412831. (www)

  @article{ , abstract = {Organoids produce through traditional manual pipetting methods face challenges such as labor-intensive procedures and batch-to-batch variability in quality. To ensure consistent organoid production, 3D bioprinting platforms offer a more efficient alternative. However, optimizing multiple printing parameters to achieve the desired organoid size remains a time-consuming and costly endeavor. To address these obstacles, machine learning is employed to optimize five critical printing parameters (i.e., bioink viscosity, nozzle size, printing time, printing pressure, and cell concentration), and develop algorithms capable of immediate cellular droplet size prediction. In this study, a high-throughput cellular droplet bioprinter is designed, capable of printing over 50 cellular droplets simultaneously, producing the large dataset required for effective machine learning training. Among the five algorithms evaluated, the multilayer perceptron model demonstrates the highest prediction accuracy, while the decision tree model offers the fastest computation time. Finally, these top-performing machine learning models are integrated into a user-friendly interface to streamline usability. The bioprinting parameter optimization platform develops in this study is expected to create significant synergy when combined with various bioprinting technologies, advancing the scalable production of organoids for a range of applications.}, archive = {J_ADVS}, author = {Jaemyung Shin and Ryan Kang and Kinam Hyun and Zhangkang Li and Hitendra Kumar and Kangsoo Kim and Simon S. Park and Keekyoung Kim}, doi = {10.1002/advs.202412831}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412831}, shortjournal = {Adv. Sci.}, title = {Machine learning-enhanced optimization for high-throughput precision in cellular droplet bioprinting}, volume = {12}, year = {2025}, }
• (2025). Construction of protein-like helical-entangled structure in lithium-ion silicon anode binders via helical recombination and hofmeister effect. ADVS, 12(20), 2412769. (www)

  @article{ , abstract = {In this study, a novel gelatin-xanthan gum composite binder is successfully developed with a protein-like helical-entangled network structure through thermo-responsive and Hofmeister effect to improve the cycling stability of silicon anodes in lithium-ion batteries. As the temperature changes, the molecular chains of xanthan gum and gelatin undergo de-helixing, intertwining, and co-helixing, ultimately self-assembling into a protein-like spatial structure. Furthermore, immersing in Hofmeister salt solution enhances the degree of helical entanglement, significantly improving strength and toughness. This novel helical-entangled structure absorbs and dissipates the stress and strain caused by silicon volume expansion through repeated bending, twisting, and stretching, similar to protein spatial structures, thereby maintaining the integrity of the silicon anode and enhancing its cycling stability. The silicon anode with the optimized binder exhibits high initial Coulombic efficiency, favorable rate performance, and long-term cycling stability. At a current density of 0.5 A g⁻¹, the silicon anode has a specific capacity of 1779.8 mAh g⁻¹ after 300 cycles, with a capacity retention rate of 80.65%. This study demonstrates the feasibility of natural polymers forming complex 3D network structures through self-assembly and intermolecular forces, providing a new approach for the design of silicon anode binders.}, archive = {J_ADVS}, author = {Shiyuan Dai and Fei Huang and Jinglun Yan and Yuan Yuan Sun and Chao Chen and HaiDong Li}, doi = {10.1002/advs.202412769}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412769}, shortjournal = {Adv. Sci.}, title = {Construction of protein-like helical-entangled structure in lithium-ion silicon anode binders via helical recombination and hofmeister effect}, volume = {12}, year = {2025}, }
• (2025). Oxide membranes from bulk micro-machining of SrTiO3 substrates. ADVS, 12(20), 2412683. (www)

  @article{ , abstract = {Suspended micro-structures made of epitaxial complex oxides rely on surface micro-machining processes based on sacrificial layers. These processes prevent to physically access the microstructures from both sides, as substantial part of the substrate is not removed. In this work, a bulk micromachining protocol is developed for a commonly used substrate employed in oxide thin films deposition. Suspended oxide thin film devices are realized by fabricating pass-through holes across SrTiO 3 (100) or SrTiO 3 (110) substrates. Careful calibration of anisotropic etching rates allows controlling the final geometry of the aperture in the substrate in a predictable way. As demonstrators of possible device geometries, clamped membranes and trampolines realized from deposited thin films of (La,Sr)MnO 3 , a conductive magnetic oxide, and a suspended trampoline resonator carved from the SrTiO 3 substrate itself are presented. Reported protocols can be readily applied to a broad variety of other complex oxides so to extend the use of membranes technology beyond those of commercially available silicon compounds.}, archive = {J_ADVS}, author = {Nicola Manca and Alejandro E. Plaza and Leonélio Cichetto and Warner J. Venstra and Cristina Bernini and Daniele Marré and Luca Pellegrino}, doi = {10.1002/advs.202412683}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412683}, shortjournal = {Adv. Sci.}, title = {Oxide membranes from bulk micro-machining of SrTiO3 substrates}, volume = {12}, year = {2025}, }
• (2025). Electrostatically reinforced double network granular hydrogels. ADVS, 12(20), 2412566. (www)

  @article{ , abstract = {Rapid advances in biomedical applications and soft robotics demand load-bearing soft materials that can be processed into complex 3D shapes. Direct ink writing (DIW) enables the fabrication of customizable shapes with locally varying compositions. Hydrogels that are formulated as microgels meet the rheological requirements that DIW imparts on the inks if they are jammed. However, most granular hydrogels are soft because inter-particle interactions are weak. These hydrogels can be reinforced with a second hydrogel, yielding double network granular hydrogels (DNGHs). Yet, DNGHs suffer from low fracture energy. This limitation is addressed by electrostatically reinforcing them. The resulting materials exhibit Young's moduli and fracture energies similar to values of cartilage and muscles. An empirical model is proposed to predict the fracture energy of these reinforced DNGHs, based on the dissipation zone size, contact area, and adhesion energy. These DNGHs can be 3D-N, N-methylene bisacrylamideprinted into free-standing structures exhibiting tuneable mechanical properties at the centimeter scale without the need for supporting structures.}, archive = {J_ADVS}, author = {Tianyu Yuan and Chenzhuo Li and John M. Kolinski and Esther Amstad}, doi = {10.1002/advs.202412566}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412566}, shortjournal = {Adv. Sci.}, title = {Electrostatically reinforced double network granular hydrogels}, volume = {12}, year = {2025}, }
• (2025). Gut microbiota modulation by inulin improves metabolism and ovarian function in polycystic ovary syndrome. ADVS, 12(20), 2412558. (www)

  @article{ , abstract = {The management of metabolic disorder associated with polycystic ovary syndrome (PCOS) has been suggested as an effective approach to improve PCOS which is highly involved with gut microbiota, while the underlying mechanism is unclear. Here, we investigated the role of inulin, a gut microbiota regulator, in the alleviation of PCOS. Our findings showed that inulin treatment significantly improved hyperandrogenism and glucolipid metabolism in both PCOS cohort and mice. Consistent with the cohort, inulin increased the abundance of microbial co-abundance group (CAG) 12 in PCOS mice, including Bifidobacterium species and other short-chain fatty acids (SCFAs)-producers. We further verified the enhancement of SCFAs biosynthesis capacity and fecal SCFAs content by inulin. Moreover, inulin decreased lipopolysaccharide-binding protein (LBP) and ameliorated ovarian inflammation in PCOS mice, whereas intraperitoneal lipopolysaccharide (LPS) administration reversed the protective effects of inulin. Furthermore, fecal microbiota transplantation (FMT) from inulin-treated patients with PCOS enhanced insulin sensitivity, improved lipid accumulation and thermogenesis, reduced hyperandrogenism and ovarian inflammatory response in antibiotic-treated mice. Collectively, these findings revealed that gut microbiota mediates the beneficial effects of inulin on metabolic disorder and ovarian dysfunction in PCOS. Therefore, modulating gut microbiota represents a promising therapeutic strategy for PCOS.}, archive = {J_ADVS}, author = {Lulu Geng and Xin Yang and Jiani Sun and Ximing Ran and Dan Zhou and Mingming Ye and Li Wen and Ruirui Wang and Miaoxin Chen}, doi = {10.1002/advs.202412558}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412558}, shortjournal = {Adv. Sci.}, title = {Gut microbiota modulation by inulin improves metabolism and ovarian function in polycystic ovary syndrome}, volume = {12}, year = {2025}, }
• (2025). SIRT4 promotes pancreatic cancer stemness by enhancing histone lactylation and epigenetic reprogramming stimulated by calcium signaling. ADVS, 12(20), 2412553. (www)

  @article{ , abstract = {Mitochondria Sirtuins including SIRT4 erase a variety of posttranslational modifications from mitochondria proteins, leading to metabolic reprogramming that acts as a tumor suppressor, oncogenic promotor, or both. However, the factors and the underlying mechanisms that stimulate and relay such a signaling cascade are poorly understood. Here, we reveal that the voltage-gated calcium channel subunit α2δ1-mediated calcium signaling can upregulate the expression of SIRT4, which is highly expressed in α2δ1-positive pancreatic tumor-initiating cells (TICs). Furthermore, SIRT4 is functionally sufficient and indispensable to promote TIC properties of pancreatic cancer cells by directly deacetylating ENO1 at K358, leading to attenuated ENO1's RNA-binding capacity, enhanced glycolytic substrate 2-PG affinity, and subsequently robust catalytic activity with boosted glycolytic ability and increased production of lactate acid. Interestingly, both SIRT4 and deacetylated mimetic of ENO1-K358 can increase the lactylation of histones at multiple sites including H3K9 and H3K18 sites, which resulted in epigenetic reprogramming to directly activate a variety of pathways that are essential for stemness. Hence, the study links α2δ1-mediated calcium signaling to SIRT4-mediated histone lactylation epigenetic reprogramming in promoting the stem cell-like properties of pancreatic cancer, which holds significant potential for the development of novel therapeutic strategies by targeting TICs of pancreatic cancer.}, archive = {J_ADVS}, author = {Mengzhu Lv and Xiaodan Yang and Congcong Xu and Qingru Song and Hailian Zhao and Tianjiao Sun and Jingtao Liu and Yuan Zhang and Guogui Sun and Yuanchao Xue and Zhiqian Zhang}, doi = {10.1002/advs.202412553}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412553}, shortjournal = {Adv. Sci.}, title = {SIRT4 promotes pancreatic cancer stemness by enhancing histone lactylation and epigenetic reprogramming stimulated by calcium signaling}, volume = {12}, year = {2025}, }
• (2025). Tumoroid model reveals synergistic impairment of metabolism by iron chelators and temozolomide in chemo-resistant patient-derived glioblastoma cells. ADVS, 12(20), 2412505. (www)

  @article{ , abstract = {Chemoresistance poses a significant clinical challenge in managing glioblastoma (GBM), limiting the long-term success of traditional treatments. Here, a 3D tumoroid model is used to investigate the metabolic sensitivity of temozolomide (TMZ)-resistant GBM cells to iron chelation by deferoxamine (DFO) and deferiprone (DFP). This work shows that TMZ-resistant GBM cells acquire stem-like characteristics, higher intracellular iron levels, higher expression of aconitase, and elevated reliance on oxidative phosphorylation and proteins associated with iron metabolism. Using a microphysiological model of GBM-on-a-chip consisting of extracellular matrix (ECM)-incorporated tumoroids, this work demonstrates that the combination of iron chelators with TMZ induces a synergistic effect on an in vitro tumoroid model of newly diagnosed and recurrent chemo-resistant patient-derived GBM and reduced their size and invasion. Investigating downstream metabolic variations reveal reduced intracellular iron, increased reactive oxygen species (ROS), upregulated hypoxia-inducible factor-1α, reduced viability, increased autophagy, upregulated ribonucleotide reductase (RRM2), arrested proliferation, and induced cell death in normoxic TMZ-resistant cells. Hypoxic cells, while showing similar results, display reduced responses to iron deficiency, less blebbing, and an induced autophagic flux, suggesting an adaptive mechanism associated with hypoxia. These findings show that co-treatment with iron chelators and TMZ induces a synergistic effect, making this combination a promising GBM therapy.}, archive = {J_ADVS}, author = {Meitham Amereh and Amir Seyfoori and Shahla Shojaei and Sarah Lane and Tian Zhao and Mahdieh Shokrollahi Barough and Julian J. Lum and Patrick Walter and Mohsen Akbari}, doi = {10.1002/advs.202412505}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412505}, shortjournal = {Adv. Sci.}, title = {Tumoroid model reveals synergistic impairment of metabolism by iron chelators and temozolomide in chemo-resistant patient-derived glioblastoma cells}, volume = {12}, year = {2025}, }
• (2025). Multiple interactions in polar lead-free perovskites toward highly stable X-ray detection. ADVS, 12(20), 2412504. (www)

  @article{ , abstract = {Lead-free halide perovskites have emerged as a promising class of high-performance “green” X-ray detecting semiconductors due to their nontoxicity and strong X-ray absorption. However, ion migration caused by high operating electric field remains a bottleneck limiting the long-term stability of perovskite X-ray detectors. Herein, by introducing multiple halogen interactions in lead-free perovskites, stable X-ray detection is successfully realized. Specifically, 0D polar bismuth halide perovskites ( R / S -BPEA) 4 Bi 2 I 10 ( 1 R / 1 S , R / S -BPEA = R / S -1-(4-bromophenyl)ethylammonium) are designed by introducing Br-substituted chiral organic cation BPEA, which exists with the molecular electrostatic forces between the Br atom and neighboring benzene ring and halogen interaction of Br···I. Notably, their introduction improves the activation energy of ion migration, which makes the dark current drift of the X-ray detector as low as 3.25 × 10 −8 nA cm −1 s −1 V −1 at 2500 V cm −1 . Furthermore, the excellent operational stability under prolonged X-ray irradiation and unchanged device sensitivity after 90 days of exposure to air, further demonstrates the improved stability of perovskites. Meanwhile, the chiral-polar characteristic of the 1 R / 1 S gives them potential for self-powered detection, with a low detection limit of 183 nGy s −1 at zero bias for single-crystal devices. This study opens new avenues for the future development of “green”, highly stable, self-powered radiation detectors.}, archive = {J_ADVS}, author = {Chang Qu and Jianbo Wu and Zeng-kui Zhu and Qianwen Guan and Huang Ye and Ruiqing Li and Chengshu Zhang and Yaru Geng and Hang Li and Lijun Xu and Haiqing Zhong and Ailin Wang and Chengmin Ji and Zhenyue Wu and Junhua Luo}, doi = {10.1002/advs.202412504}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412504}, shortjournal = {Adv. Sci.}, title = {Multiple interactions in polar lead-free perovskites toward highly stable X-ray detection}, volume = {12}, year = {2025}, }
• (2025). Low-irradiance antimicrobial blue light-bathing therapy for wound infection control. ADVS, 12(20), 2412493. (www)

  @article{ , abstract = {The prevalence of antibiotic resistance and tolerance in wound infection management poses a serious and growing health threat, necessitating the exploration of alternative approaches. Antimicrobial blue light therapy offers an appealing, non-pharmacological solution. However, its practical application has been hindered by the requirement for high irradiance levels (50–200 mW/cm 2 ), which particularly raises safety concerns. Here, a light-bathing strategy is introduced that employs prolonged, continuous exposure to blue light at an irradiance range lower by more than an order of magnitude (5 mW/cm 2 ). This method consistently applies bacteriostatic pressure, keeping wound bioburden low, all while minimizing photothermal risks. Leveraging tailor-made, wearable light-emitting patches, preclinical trials on rat models of wound infection are conducted, demonstrating its safety and efficacy for suppressing infections induced by methicillin-resistant Staphylococcus aureus ( S. aureus ) and multidrug-resistant Pseudomonas aeruginosa ( P. aeruginosa ). The results pave a new way for the application of blue light therapy in wound care.}, archive = {J_ADVS}, author = {Jie Hui and Wonjoon Moon and Pu-Ting Dong and Carolina dos Anjos and Laisa Negri and Hao Yan and Ying Wang and Joshua Tam and Tianhong Dai and R. Rox Anderson and Jeremy Goverman and Jeffrey A. Gelfand and Seok-Hyun Yun}, doi = {10.1002/advs.202412493}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412493}, shortjournal = {Adv. Sci.}, title = {Low-irradiance antimicrobial blue light-bathing therapy for wound infection control}, volume = {12}, year = {2025}, }
• (2025). Zonated copper-driven breast cancer progression countered by a copper-depleting nanoagent for immune and metabolic reprogramming. ADVS, 12(20), 2412434. (www)

  @article{ , abstract = {While studies of various carcinomas have reported aberrant metal metabolism, much remains unknown regarding their spatial accumulation and regulatory impacts in tumors. Here, elevated copper levels are detected in breast cancer tumors from patients and animal models, specifically exhibiting a zonate spatial pattern. Spatially resolved multiomics analyses reveal that copper zonation drives a tumor metabolic preference for oxidative phosphorylation (OXPHOS) over glycolysis and promotes tumor metastatic and immune-desert phenotypes. Then, a copper-depleting nanoagent is developed based on copper chelator tetrathiomolybdate (TM)-loaded hybridized bacterial outer membrane vesicles (hOMVs) from both Akkermansia muciniphila bacteria and CD326-targeting peptide-engineered Escherichia coli (TM@ CD326 hOMV). Systemic administration of TM@ CD326 hOMV reduces the labile copper level in tumors and inhibits both tumor growth and metastatic phenotypes, specifically through metabolic reprograming of OXPHOS toward glycolysis and restoration of antitumor immunity responses involving natural killer cells, CD4 + T cells, and cytotoxic CD8 + T cells in tumors. Assessing survival in murine breast cancer models, a combination of TM@ CD326 hOMV and a checkpoint blockade agent outperforms monotherapies. Notably, a copper-rich diet undermines the therapeutic efficacy of TM@ CD326 hOMV. Beyond demonstrating an effective nanoagent for treating breast cancer, this study deepens the understanding of how the pattern of copper accumulation in tumors affects pathophysiology and immunity.}, archive = {J_ADVS}, author = {Lin Chen and Saibo Ma and Hao Wu and Lingna Zheng and Yunpeng Yi and Guangnian Liu and Baoyi Li and Jiayi Sun and Yang Du and Bing Wang and Yike Liu and Cheng Zhang and Jing Chang and Yuheng Pang and Wenjing Wang and Meng Wang and Motao Zhu}, doi = {10.1002/advs.202412434}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412434}, shortjournal = {Adv. Sci.}, title = {Zonated copper-driven breast cancer progression countered by a copper-depleting nanoagent for immune and metabolic reprogramming}, volume = {12}, year = {2025}, }
• (2025). ROS-activated nanohydrogel scaffolds with multi-factors controlled release for targeted dual-lineage repair of osteochondral defects. ADVS, 12(20), 2412410. (www)

  @article{ , abstract = {Achieving self-healing for osteochondral defects caused by trauma, aging, or disease remains a significant challenge in clinical practice. It is an effective therapeutic strategy to construct gradient-biomimetic biomaterials that replicate the hierarchical structure and complex microenvironment of osteochondral tissues for dual-lineage regeneration of both cartilage and subchondral bone. Herein, ROS-activated nanohydrogels composite bilayer scaffolds with multi-factors controlled release are rationally designed using the combination of 3D printing and gelatin placeholder methods. The resulting nanohydrogel scaffolds exhibit micro-nano interconnected porous bilayer structure and soft-hard complex mechanical strength for facilitating 3D culture of BMSCs in vitro. More importantly, multi-stage continuous responses of anti-inflammation, chondrogenesis and osteogenesis, are effectively induced via the sequential release of multi-factors, including diclofenac sodium (DS), kartogenin (KGN) and bone morphogenetic protein 2 (BMP-2), from ROS-activated nanohydrogel scaffolds, thereby improved dual-lineage regeneration of cartilage and subchondral bone tissue in the osteochondral defect model of SD rats. These findings suggest that ROS-activated nanohydrogel scaffolds with such specific soft-hard bilayer structure and sequential delivery of functional factors, provides a promising strategy in dual-lineage regeneration of osteochondral defects.}, archive = {J_ADVS}, author = {Xiuhui Wang and Shunli Wu and Ruiyang Li and Huijian Yang and Yue Sun and Zijie Cao and Xiao Chen and Yan Hu and Hao Zhang and Zhen Geng and Long Bai and Zhongmin Shi and Ke Xu and Hongbo Tan and Jiacan Su}, doi = {10.1002/advs.202412410}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412410}, shortjournal = {Adv. Sci.}, title = {ROS-activated nanohydrogel scaffolds with multi-factors controlled release for targeted dual-lineage repair of osteochondral defects}, volume = {12}, year = {2025}, }
• (2025). MEA-seqX: High-resolution profiling of large-scale electrophysiological and transcriptional network dynamics. ADVS, 12(20), 2412373. (www)

  @article{ , abstract = {Concepts of brain function imply congruence and mutual causal influence between molecular events and neuronal activity. Decoding entangled information from concurrent molecular and electrophysiological network events demands innovative methodology bridging scales and modalities. The MEA-seqX platform, integrating high-density microelectrode arrays, spatial transcriptomics, optical imaging, and advanced computational strategies, enables the simultaneous recording and analysis of molecular and electrical network activities at mesoscale spatial resolution. Applied to a mouse hippocampal model of experience-dependent plasticity, MEA-seqX unveils massively enhanced nested dynamics between transcription and function. Graph–theoretic analysis reveals an increase in densely connected bimodal hubs, marking the first observation of coordinated hippocampal circuitry dynamics at molecular and functional levels. This platform also identifies different cell types based on their distinct bimodal profiles. Machine-learning algorithms accurately predict network-wide electrophysiological activity features from spatial gene expression, demonstrating a previously inaccessible convergence across modalities, time, and scales.}, archive = {J_ADVS}, author = {Brett Addison Emery and Xin Hu and Diana Klütsch and Shahrukh Khanzada and Ludvig Larsson and Ionut Dumitru and Jonas Frisén and Joakim Lundeberg and Gerd Kempermann and Hayder Amin}, doi = {10.1002/advs.202412373}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412373}, shortjournal = {Adv. Sci.}, title = {MEA-seqX: High-resolution profiling of large-scale electrophysiological and transcriptional network dynamics}, volume = {12}, year = {2025}, }
• (2025). Screening and identification of novel DNA aptamer for targeted delivery to injured podocytes in glomerular diseases. ADVS, 12(20), 2412356. (www)

  @article{ , abstract = {Selective drug delivery to podocytes remains a challenge. Aptamers, nucleic acids that bind specific cells, offer a potential solution, though podocyte-targeting aptamers have not yet been developed. Podocytes stimulated with adriamycin, puromycin aminonucleoside, and high glucose are used to screen an single-stranded DNA (ssDNA) library (10¹⁵ sequences). High-throughput sequencing identifies nucleotide sequences, and the aptamer's affinity, stability, cytotoxicity, uptake, biodistribution (especially to podocyte), target protein and ability to deliver siRNA are evaluated. After 11–14 rounds of selection, high-affinity pools are identified. Sequencing reveals 23,848 unique sequences, narrowed down to 12 candidates. Aptamer S7 is specifically bound to podocytes, and its truncated version, RLS-2, demonstrates superior affinity (50–70 nM) and improved stability with phosphorothioate modifications. RLS-2 exhibits no significant cytotoxicity, is internalized by podocytes, and localized to lysosomes. In adriamycin-induced and diabetic nephropathy mice, RLS-2 preferentially accumulates within glomeruli. Its specificity to podocyte is verified by colocalization examination and quantitated via flowcytometry. EPB41L5 is identified as a target protein. Aptamer-siRNA chimeras based on RLS-2 successfully downregulate gene expression without the need for transfection reagents in vitro. These findings underscore the potential of RLS-2 as a promising agent for the development of podocyte-targeted drug delivery systems.}, archive = {J_ADVS}, author = {Chao Zhou and Zhaofeng Luo and Zheng Zhang and Qing Ye and Dongjie Wang and Hanyan Meng and Jiayu Zhang and Shifan Zhu and Lidan Hu and Jianhua Mao}, doi = {10.1002/advs.202412356}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412356}, shortjournal = {Adv. Sci.}, title = {Screening and identification of novel DNA aptamer for targeted delivery to injured podocytes in glomerular diseases}, volume = {12}, year = {2025}, }
• (2025). Delivery of human iPSC-derived RPE cells in healthy minipig retina results in interaction between photoreceptors and transplanted cells. ADVS, 12(20), 2412301. (www)

  @article{ , abstract = {In late stages of inherited and acquired retinal diseases such as Stargardt disease (STGD) or dry age-related macular degeneration (AMD), loss of retinal pigment epithelia (RPE) cells and subsequently photoreceptors in the macular area result in a dramatic decline of central visual function. Repopulating this area with functional RPE cells may prevent or decline the progression of photoreceptor loss. In the present study, the viability, survival, and integration of human induced pluripotent stem cell (hiPSC)-derived RPE cells (hiPSC-RPE) is assessed generated using clinical-grade protocol and cultured on a clinically relevant scaffold (poly-L-lactide- co -D, L-lactide, PDLLA) after subretinal implantation in immunosuppressed minipigs for up to 6 weeks. It is shown that transplanted hiPSC-RPE cells maintain the RPE cell features such as cell polarity, hexagonal shape, and cell–cell contacts, and interact closely with photoreceptor outer segments without signs of gliosis or neuroinflammation throughout the entire period of examination. In addition, an efficient immunosuppressing strategy with a continuous supply of tacrolimus is applied. Continuous verification and improvement of existing protocols are crucial for its translation to the clinic. The results support the use of hiPSC-RPE on PDLLA scaffold as a cell replacement therapeutic approach for RPE degenerative diseases.}, archive = {J_ADVS}, author = {Anna Macečková Brymová and Francisco Javier Rodriguez-Jimenez and Annika Konrad and Yaroslav Nemesh and Muhammed Arshad Thottappali and Ana Artero-Castro and Ruslan Nyshchuk and Anastasiia Kolesnikova and Brigitte Müller and Hana Studenovska and Jana Juhasova and Stefan Juhas and Ivona Valekova and Dunja Lukovic and Claudia Aleman and Taras Ardan and Saskia Drutovič and Jan Motlik and Zdenka Ellederova and Zbinek Straňák and Miroslav Veith and Lyubomyr Lytvynchuk and Ruchi Sharma and Kapil Bharti and Goran Petrovski and Pavla Jendelova and Knut Stieger and Slaven Erceg}, doi = {10.1002/advs.202412301}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412301}, shortjournal = {Adv. Sci.}, title = {Delivery of human iPSC-derived RPE cells in healthy minipig retina results in interaction between photoreceptors and transplanted cells}, volume = {12}, year = {2025}, }
• (2025). Controllable crystalline phases of multi-cation oxides. ADVS, 12(20), 2412280. (www)

  @article{ , abstract = {Multi-cation oxides have been extensively studied over the past decade for various solid-state applications. The source of their functionality lies in a wide compositional search space derived from countless cation combinations and diverse crystal structures formed in metal oxides. However, due to the vast space and complexity of structure control, material exploration has been limited to dispersed compositions under different synthesis conditions, hindering their systematic understanding and rational design. Here, a crystalline-phase map of multi-cation rare-earth titanates is reported, where three types of crystals, i.e., cubic and hexagonal, and orthorhombic phases, emerge depending on the composition and temperature and exhibit systematic changes. The crystal structures of each phase are thoroughly characterized with X-ray diffraction, electron microscopy, and first-principles calculations. The configurational entropies calculated from the crystallographic information support the phase-boundary shift between hexagonal and orthorhombic phases observed in the phase map. Further, a machine learning procedure is proposed for constructing the map from sparse experimental data, allowing predictive exploration for stable crystalline phases across a large compositional space. These findings may facilitate the design of multi-cation oxides with a desired structure dispersed in a large search space.}, archive = {J_ADVS}, author = {Takafumi Ogawa and Makoto Tanaka and Naoki Kawashima and Taishi Ito and Kei Nakayama and Takeharu Kato and Satoshi Kitaoka}, doi = {10.1002/advs.202412280}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2412280}, shortjournal = {Adv. Sci.}, title = {Controllable crystalline phases of multi-cation oxides}, volume = {12}, year = {2025}, }
• (2025). A novel protein NAB1-356 encoded by circRNA circNAB1 mitigates atrial fibrillation by reducing inflammation and fibrosis. ADVS, 12(20), 2411959. (www)

  @article{ , abstract = {Atrial fibrillation (AF) is a common arrhythmia with irregular atrial electrical activity. Circular RNAs (circRNAs) are key regulators in tissue homeostasis, yet their role in AF remains unclear. Here, we investigated the expression and function of circNAB1 in AF using high-throughput sequencing and functional assays in circNAB1 transgenic mice. We identified circNAB1 as a significantly downregulated circRNA in AF patient specimens. Silencing circNAB1 promoted collagen deposition and inflammation, whereas overexpression reduces atrial fibrosis and AF susceptibility in mice, consistent with results observed in human atrial tissues. Mechanistically, circNAB1 translates into a novel protein, NAB1-356, which is highly expressed in human cardiac hypertrophy. NAB1-356 interacts with EGR1 as NAB1 does, decreasing fibrosis and inflammation in the atrium. Furthermore, NAB1-356 also regulates transcription factor Runx1 and Gadd45b transcription, exerting regulatory effects on cytokine expression and fibrosis. Targeting EGR1, Gadd45b, and Runx1 by circNAB1 or siRNAs attenuate AF incidence and cardiac remodeling, suggesting potential therapeutic strategies for AF management. Delivery of circNAB1 improves AF conditions in LKB1 knockout mice, further highlighting its anti-arrhythmic potential. Our findings elucidate the mechanistic role of circNAB1 in AF pathogenesis and suggest its therapeutic implications for cardiac remodeling-associated disorders.}, archive = {J_ADVS}, author = {William W Du and Muhammad Rafiq and Hui Yuan and Xiangmin Li and Sheng Wang and Jun Wu and Jinfeng Wei and Ren-Ke Li and Huiming Guo and Burton B Yang}, doi = {10.1002/advs.202411959}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411959}, shortjournal = {Adv. Sci.}, title = {A novel protein NAB1-356 encoded by circRNA circNAB1 mitigates atrial fibrillation by reducing inflammation and fibrosis}, volume = {12}, year = {2025}, }
• (2025). Paclitaxel/Luteolin coloaded dual-functional liposomes for esophageal cancer therapy. ADVS, 12(20), 2411930. (www)

  @article{ , abstract = {Combination therapy integrating chemotherapeutic agents with natural bioactive ingredients represents an attractive strategy for esophageal squamous cell carcinoma (ESCC) treatment, yet achieving tumor-specific co-delivery remains a critical challenge. Herein, we report that the combination of luteolin (LUT) and paclitaxel (PTX) exerts a remarkable synergy in ESCC treatment, while concurrently alleviating PTX-induced hepatotoxicity; EA2 aptamer has been identified for its exceptional specificity and strong affinity toward Catenin Alpha 1 protein (CTNNA1) in ESCC cells. Leveraging this specificity, nanosized EA2-modified pH-sensitive liposomes (EA2-PSL-PTX/LUT) are successfully developed with effective co-loading, controlled release, and good biostability. EA2-PSL-PTX/LUT exhibits stimuli-triggered release in the acidic tumor microenvironment and facilitates specific cellular uptake and endosomal escape in ESCC cells. In vivo imaging confirms precise tumor localization, deep tumor penetration, and prolonged retention of the nanocarrier. In vitro and in vivo findings validate that the nanocarrier potentiates synergistic inhibitions of PTX and LUT. Notably, EA2-PSL-PTX/LUT significantly activates the tumor microenvironment by promoting dendritic cell maturation and T cell infiltration. And the immunosuppressive microenvironment has been remodeled by decreasing myeloid-derived suppressor cells and regulatory T cell accumulation. This study provides a strategy for precise delivery of combinational chemotherapeutic drugs for ESCC targeted therapy.}, archive = {J_ADVS}, author = {Congyong Sun and Fei Xie and Huiyun Zhang and Lulu Feng and Yuting Wang and Chaofan Huang and Zhizhen Cui and Chao Luo and Li Zhang and Qilong Wang}, doi = {10.1002/advs.202411930}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411930}, shortjournal = {Adv. Sci.}, title = {Paclitaxel/Luteolin coloaded dual-functional liposomes for esophageal cancer therapy}, volume = {12}, year = {2025}, }
• (2025). From invaginating site to deep lesion: Spatial transcriptomics unravels ectopic endometrial penetration features in adenomyosis. ADVS, 12(20), 2411752. (www)

  @article{ , abstract = {Adenomyosis, characterized by clinical intractability, significantly impacts female fertility and life quality due to the absence of definitive diagnostic markers and effective treatment options. The invagination theory is a primary hypothesis for adenomyosis, but the underlying molecular mechanisms remain unclear. In this study, a spatial transcriptional landscape of adenomyosis with an evident invagination structure is mapped from the endometrial invaginating site to ectopic lesions utilizing spatial transcriptomics and single-cell RNA sequencing. In addition, the authors employ bulk RNA sequencing deconvolution to assess the significance of core spatial ecotypes, use histological techniques to target specific cell types, and conduct in vitro experiments for validation. At the invagination site, SFRP5 + epithelial cells promote endometrial proliferation and angiogenesis through secretion of IHH. During the invading process, ESR1 + smooth muscle cells (SMCs) facilitate invasion by creating migratory tracts via collagen degradation. Within deep lesions, CNN1 + stromal fibroblasts induce fibrosis by undergoing a fibroblast-to-myofibroblast transition (FMT) in response to pathologic profibrogenic signals in the microenvironment of lesions. This work offers an in-depth understanding of the molecular mechanisms underlying the pathological processes of adenomyosis with invagination. Furthermore, this work introduces the first transcriptomics web source of adenomyosis, which is expected to be a valuable resource for subsequent research.}, archive = {J_ADVS}, author = {Boyu Li and Jia Qi and Yumeng Cao and Yijing Long and Zhe Wei and Wang-Sheng Wang and Shuanggang Hu and Yuan Wang and Qinling Zhu and Xiao Hu and Zhe Sun and Jie Zhu and Taiyang Ye and Yejie Yao and Yiwen Meng and Xuejiao Bian and Xinyi Dong and Hengyu Guan and Yunfei Huang and Yun Sun}, doi = {10.1002/advs.202411752}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411752}, shortjournal = {Adv. Sci.}, title = {From invaginating site to deep lesion: Spatial transcriptomics unravels ectopic endometrial penetration features in adenomyosis}, volume = {12}, year = {2025}, }
• (2025). HESCs-derived organoids achieve liver zonation features through LSEC modulation. ADVS, 12(20), 2411667. (www)

  @article{ , abstract = {Liver zonation, essential for diverse physiological functions, is lacking in existing organoid models, hindering their ability to recapitulate liver development and pathogenesis. Addressing this gap, this work explores the feasibility of achieving zonated organoid by co-culturing human embryonic stem cells (hESCs) derived hepatocytes (HEP) with hESCs derived liver sinusoidal endothelial cells (LSECs) exhibiting characteristics of either the liver lobule's pericentral (PC) or periportal (PP) regions. Introducing zonated LSECs with variable WNT2 signaling subtly regulate hepatocyte zonation, resulting in noticeable metabolic function changes. Considering the lipid metabolism variations in PC and PP organoids, this work constructs biomimetic zonated metabolic dysfunction-associated steatotic liver disease (MASLD) organoids and revealed that glucagon-like peptide-1 receptor agonist (GLP-1RA) directly target LSECs, indicating potential therapeutic mechanisms of GLP-1RA in MAFLD alleviation. This study highlights the crucial role of non-parenchymal cells in organoids for recapitulating niche heterogeneity, offering further insights for drug discovery and in vitro modeling of organ heterogeneity.}, archive = {J_ADVS}, author = {Yuying Zhang and Chenyan Huang and Lei Sun and Lyu Zhou and Yudi Niu and Kaini Liang and Bingjie Wu and Peng Zhao and Zhiqiang Liu and Xiaolin Zhou and Peng Zhang and Jianchen Wu and Jie Na and Yanan Du}, doi = {10.1002/advs.202411667}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411667}, shortjournal = {Adv. Sci.}, title = {HESCs-derived organoids achieve liver zonation features through LSEC modulation}, volume = {12}, year = {2025}, }
• (2025). Affinity-based isolation and one-pot analysis of extracellular vesicles from biofluids using phase separated zwitterionic coacervates. ADVS, 12(20), 2411653. (www)

  @article{ , abstract = {Extracellular vesicles (EVs) hold promise for liquid biopsy and drug delivery applications. However, their heterogeneous nature poses challenges for efficient and selective isolation from complex biofluids. Here, an isolation method based on phase-separated zwitterionic (ZW) coacervates is developed. These coacervates form over a wide range of pH values and ionic strengths, ensuring compatibility with all biofluids. They exhibit antifouling properties that minimize nonspecific binding, allowing for the selective isolation of EVs from biofluids upon functionalization of the polymer with a suitable affinity probe, as proved here with a membrane-sensing peptide. This strategy is applied to pull down, concentrate, and release EVs from urine samples with high yields while retaining their structural integrity. This approach effectively separates EVs from lipoproteins, a challenging task for conventional separation techniques. The power of the approach is demonstrated as a preparative step for downstream analysis and as a one-pot assay to profile EV biomarkers in complex fluids. The latter application, implemented here with flow cytometry, significantly streamlines pre-analytical workflows. Thus, functionalized ZW coacervates represent an effective strategy for the selective isolation and direct analysis of EVs from complex mixtures, paving the way for advances in large-scale manufacturing and diagnostics.}, archive = {J_ADVS}, author = {Francesca Torrini and Roberto Frigerio and Jonathan Garlipp and Philippe Lenzen and Karl Normak and Carolina Paganini and Marina Cretich and Alessandro Gori and Paolo Arosio}, doi = {10.1002/advs.202411653}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411653}, shortjournal = {Adv. Sci.}, title = {Affinity-based isolation and one-pot analysis of extracellular vesicles from biofluids using phase separated zwitterionic coacervates}, volume = {12}, year = {2025}, }
• (2025). Immune and angiogenic profiling of mesenchymal stem cell functions in a subcutaneous microenvironment for allogeneic islet transplantation. ADVS, 12(20), 2411574. (www)

  @article{ , abstract = {Islet transplantation offers a promising treatment for type 1 diabetes (T1D), by aiming to restore insulin production and improve glycemic control. However, T1D is compounded by impaired angiogenesis and immune dysregulation, which hinder the therapeutic potential of cell replacement strategies. To address this, this work evaluates the proangiogenic and immunomodulatory properties of mesenchymal stem cells (MSCs) to enhance vascularization and modulate early-stage immune rejection pathways in the context of islet allotransplantation. This work employs the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) platform, a subcutaneous vascularized implant with localized immunomodulation developed by the group. This study assesses vascularization and immune regulation provided by MSCs, aiming to improve islet survival and integration in diabetic rats while considering sex as a biological variable. These findings demonstrate that MSCs significantly enhance vascularization and modulate the local microenvironment during the peri-transplant period. Importantly, this work discovers sex-specific differences in both processes, which influence islet engraftment and long-term function.}, archive = {J_ADVS}, author = {Jocelyn Nikita Campa-Carranza and Simone Capuani and Ashley L. Joubert and Nathanael Hernandez and Tommaso Bo and Octavio I. Sauceda-Villanueva and Marzia Conte and Letizia Franco and Marco Farina and Gabrielle E. Rome and Yitian Xu and Junjun Zheng and Lissenya B. Argueta and Jean A. Niles and Fotis Nikolos and Corrine Ying Xuan Chua and Shu-Hsia Chen and Joan E. Nichols and Norma S. Kenyon and Alessandro Grattoni}, doi = {10.1002/advs.202411574}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411574}, shortjournal = {Adv. Sci.}, title = {Immune and angiogenic profiling of mesenchymal stem cell functions in a subcutaneous microenvironment for allogeneic islet transplantation}, volume = {12}, year = {2025}, }
• (2025). Mas signaling potentiates neutrophil extracellular traps formation induced by endothelial cells derived S1P in mice with acute liver failure. ADVS, 12(20), 2411428. (www)

  @article{ , abstract = {Mas, a newly identified G-protein-coupled receptor, is prevalent in myeloid-derived immune cells and plays a key role in inflammation. This study investigates Mas signaling and neutrophil extracellular traps (NETs) in acute liver failure (ALF), aiming to elucidate their mechanisms. Male Mas1 −/− and wild-type mice, aged 6–8 weeks, receive intraperitoneally injected with lipopolysaccharide (LPS)/D-galactosamine (D-Gal) (L/G) to study NETs formation. Hepatic Mas expression increases in WT-L/G mice, whereas systemic Mas1 knockout significantly reduces L/G-induced NETs and hepatotoxicity. Antibiotics treatment and co-housing ( Mas1 −/− -L/G and WT-L/G mice) experiments show that gut flora influences the disease phenotype in Mas1 −/− -L/G mice. Fecal metabolite analysis suggests that mice may be protected by reduced deoxycholic acid (DCA) production in Mas1 −/− activated hepatic farnesoid X receptor (FXR), suppressing sphingosine-1-phosphate (S1P)-dependent NETs. Additionally, Mas1 −/− also activates the FXR-S1P-NETs axis in the liver by inhibiting SHP2. Single-cell sequencing shows decreased interaction between endothelial cells and Cldn1 + CD177 + senescent neutrophils through Col4a1-CD44. This inhibits S1P-induced Raf signaling pathway activation and NETs formation. Mas signaling significantly impacts NETs formation, highlighting its potential as an anti-inflammatory therapeutic target for ALF.}, archive = {J_ADVS}, author = {Bo Yang and Shuai Chen and Xiaoqi Xia and Ziwen Tao and Chun Liu and Shanshan Li and Shuo Zhang and Jiali Huang and Lu Xia and Wenqiang Quan and Changqing Yang and Jing Li}, doi = {10.1002/advs.202411428}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411428}, shortjournal = {Adv. Sci.}, title = {Mas signaling potentiates neutrophil extracellular traps formation induced by endothelial cells derived S1P in mice with acute liver failure}, volume = {12}, year = {2025}, }
• (2025). Caspase-6/Gasdermin C-mediated tumor cell pyroptosis promotes colorectal cancer progression through CXCL2-dependent recruitment of myeloid-derived suppressor cells. ADVS, 12(20), 2411375. (www)

  @article{ , abstract = {Gasdermin (GSDM) family proteins mediate inflammatory cell pyroptosis and exert critical contributions to the pathogenesis of gastrointestinal cancers, infections, and gut mucosal inflammation. Gasdermin C (GSDMC) is overexpressed in human colorectal cancer (CRC); however, the molecular mechanisms underlying GSDMC regulation of CRC tumorigenesis are largely elusive. Here, it is found that both GSDMC expression and activation are significantly elevated in human and mouse CRC tissues. Gsdmc2/3/4 deficiency attenuates tumor progression in both chemically induced CRC mouse model and spontaneous intestinal tumor model. Mechanistically, under hypoxia and low-glucose condition, GSDMC2/3/4 are directly activated by Caspase-6, but not by Caspase-8, as previously reported in other cancers. GSDMC2/3/4-mediated pyroptosis in tumor cells leads to the release of high mobility group protein B1 (HMGB1), which enhances the expression of chemokine attractant C-X-C motif chemokine 2 (CXCL2) in surrounding tumor cells. Subsequently, the elevated CXCL2 secretion from tumor cells promotes the recruitment of myeloid-derived suppressor cells (MDSCs) into the tumor microenvironment (TME) through C-X-C chemokine receptor type 2 (CXCR2), thereby facilitating CRC progression. These findings reveal a mechanism by which Caspase-6/GSDMC-mediated tumor cell pyroptosis, in response to hypoxic and low-glucose conditions, remodels the immunosuppressive microenvironment through CXCL2-dependent recruitment of MDSCs. These results identify GSDMC as a potential drug target for CRC therapy.}, archive = {J_ADVS}, author = {Hanchao Gao and Yikun Yao and Weilong Li and Zigan Xu and Wenjun Hu and Kewang Luo and Peishan Chen and Wanjing Shang and Shaodong Luan and Guojun Shi and Mengtao Cao and Pengfei Chen}, doi = {10.1002/advs.202411375}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411375}, shortjournal = {Adv. Sci.}, title = {Caspase-6/Gasdermin C-mediated tumor cell pyroptosis promotes colorectal cancer progression through CXCL2-dependent recruitment of myeloid-derived suppressor cells}, volume = {12}, year = {2025}, }
• (2025). Copy number gains of VPS72 drive de novo lipogenesis and hepatocarcinogenesis via ATF3/mTORC1/SREBP1 axis. ADVS, 12(20), 2411368. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and a major contributor to cancer-related mortality globally. Central to its pathogenesis is the dysregulation of lipid metabolism in hepatocytes, leading to abnormal lipid accumulation. Our bioinformatics analysis has identified the histone acetyltransferase complex subunit VPS72 as being associated with HCC, yet the precise molecular mechanisms through which VPS72 contributes to hepatocarcinogenesis remain poorly understood. Our analysis of extensive HCC patient cohorts identifies a significant proportion with VPS72 copy number gains, which are strongly linked to adverse prognostic outcomes. By integrating RNA-Seq, ChIP-Seq, ATAC-seq, and experimental validation, we show that VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. We further uncover that VPS72 modulates the epigenetic landscape by enhancing DNA methylation at the ATF3 promoter, resulting in ATF3 repression and subsequent activation of mTORC1. This study elucidates a novel regulatory axis that links dysregulated lipid metabolism with HCC progression, highlighting potential epigenetic and metabolic targets for therapeutic intervention.}, archive = {J_ADVS}, author = {Qinglin Zhang and Yunxing Huang and Yin Tong and Kenneth Tsz Chun Ng and Jiangwen Zhang}, doi = {10.1002/advs.202411368}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411368}, shortjournal = {Adv. Sci.}, title = {Copy number gains of VPS72 drive de novo lipogenesis and hepatocarcinogenesis via ATF3/mTORC1/SREBP1 axis}, volume = {12}, year = {2025}, }
• (2025). Structural diversity of mitochondria in the neuromuscular system across development revealed by 3D electron microscopy. ADVS, 12(20), 2411191. (www)

  @article{ , abstract = {As an animal matures, its neural circuit undergoes alterations, yet the developmental changes in intracellular organelles to facilitate these changes is less understood. Using 3D electron microscopy and deep learning, the study develops semi-automated methods for reconstructing mitochondria in C . elegans and collected mitochondria reconstructions from normal reproductive stages and dauer, enabling comparative study on mitochondria structure within the neuromuscular system. It is found that various mitochondria structural properties in neurons correlate with synaptic connections and these properties are preserved across development in different neural circuits. To test the necessity of these universal mitochondria properties, the study examines the behavior in drp-1 mutants with impaired mitochondria fission and discovers that it causes behavioral deficits. Moreover, it is observed that dauer neurons display distinctive mitochondrial features, and mitochondria in dauer muscles exhibit unique reticulum-like structure. It is proposed that these specialized mitochondria structures may serve as an adaptive mechanism to support stage-specific behavioral and physiological needs.}, archive = {J_ADVS}, author = {J. Alexander Bae and Myung-kyu Choi and Soungyub Ahn and Gwanho Ko and Daniel T. Choe and Hyunsoo Yim and Ken C. Nguyen and Jinseop S. Kim and David H. Hall and Junho Lee}, doi = {10.1002/advs.202411191}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411191}, shortjournal = {Adv. Sci.}, title = {Structural diversity of mitochondria in the neuromuscular system across development revealed by 3D electron microscopy}, volume = {12}, year = {2025}, }
• (2025). Gut microbiota-butyrate-PPARγ axis modulates adipose regulatory t cell population. ADVS, 12(20), 2411086. (www)

  @article{ , abstract = {Gut microbiota is essential for the function of peripherally-induced regulatory T (pTreg) cells. However, how commensal bacteria affect thymically derived fat-resident Treg cells that harbor a unique expression of peroxisome proliferator-activated receptor (PPAR)-γ and suppress inflammation in visceral adipose tissue (VAT), is not well defined. Here it is revealed that microbiota depletion causes a drastic decline in Treg cell population in VAT, particularly those expressing ST2 (ST2 + Treg), which are largely restored after gut microbiome reconstruction. Mechanistically, gut microbiota-derived butyrate increases VAT ST2 + Treg cells through binding PPARγ. Butyrate supplementation and high fiber diet increase VAT ST2 + Treg population in obese mice, and ameliorated glucose tolerance and visceral inflammation. Furthermore, human omental adipose Treg cells show positive correlation with fecal butyrate and certain butyrate-producing microbes. This study identifies the critical role of gut microbiota-butyrate-PPARγ axis in maintaining VAT Treg population, pinpointing a potential approach to augment VAT Treg population and ameliorate inflammation.}, archive = {J_ADVS}, author = {Banru Chen and Lizhi Guan and Chao Wu and Yiwen Gong and Lei Wu and Minchun Zhang and Zhiwen Cao and Yufei Chen and Chengcan Yang and Bing Wang and Yunqi Li and Bin Li and Yufang Bi and Guang Ning and Jiqiu Wang and Weiqing Wang and Ruixin Liu}, doi = {10.1002/advs.202411086}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2411086}, shortjournal = {Adv. Sci.}, title = {Gut microbiota-butyrate-PPARγ axis modulates adipose regulatory t cell population}, volume = {12}, year = {2025}, }
• (2025). Delivery of a chemically modified noncoding RNA domain improves dystrophic myotube function. ADVS, 12(20), 2410908. (www)

  @article{ , abstract = {Fast twitch muscle fibers are prone to degradation in skeletal muscle pathologies, such as sarcopenia and muscular dystrophies. We previously showed that the exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis. Here, we identify an independent functional element within human CYTOR, and optimize its RNA delivery. In human primary myoblasts exogenous CYTOR exon 2 recapitulates the effect of full-length CYTOR by boosting fast-twitch myogenic differentiation. Furthermore, chemically modified CYTOR exon 2 RNA ΨU (N1-me-PseudoU, 7-methyl guanosine 5′Cap, polyA) enhances RNA stability and reduces immunogenicity to CYTOR exon2 RNA. Viral- or chemically optimized RNA-mediated CYTOR exon2 administration drives commitment toward myogenic maturation in Duchenne muscular dystrophy-derived primary myoblasts, myogenic progenitor cells, and mouse embryonic stem cells. Furthermore, CYTOR exon2, m1ΨU improves key disease characteristics in dystrophic myotubes, including calcium handling and mitochondrial bioenergetics. In summary, we identify CYTOR exon 2 as the functional domain of CYTOR that can be delivered in a disease context using chemical modifications. This is of particular importance given the susceptibility of fast muscle fibers in different muscle pathologies such as aging and dystrophies, and the oncogenic effect of CYTOR exon 1. This study, therefore, highlights the potential of identifying functional domains in noncoding RNAs. Delivery, or targeting of RNA domains might constitute next-generation RNA therapeutics.}, archive = {J_ADVS}, author = {Zeinabou Niasse-Sy and Bo Zhao and Ajda Lenardič and Huyen Thuc Tran Luong and Ori Bar-Nur and Johan Auwerx and Martin Wohlwend}, doi = {10.1002/advs.202410908}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410908}, shortjournal = {Adv. Sci.}, title = {Delivery of a chemically modified noncoding RNA domain improves dystrophic myotube function}, volume = {12}, year = {2025}, }
• (2025). From de novo conceived small molecules to multifunctional supramolecular nanoparticles: Dual biofilm and T3SS intervention, enhanced foliar affinity, and effective rice disease control. ADVS, 12(20), 2410878. (www)

  @article{ , abstract = {Conventional antimicrobials typically exhibit suboptimal deposition on rice leaves, resulting in poor efficacy, further impaired by biofilms and Type III Secretion Systems (T3SS). Herein, this study presents a supramolecular strategy to fabricate BtP27@ β -CD, a sunflower-like material engineered through host-guest recognition between de novo designed molecule BtP27 and β -cyclodextrin. BtP27@ β -CD manifests enhanced foliar affinity and in vivo efficiency, demonstrating superior protective (62.67%) and curative (51.16%) activities against bacterial leaf blight at a low-dose of 200 µg mL −1 compared to commercial thiodiazole-copper (37.78%/38.13%) without compromising safety. This multifunctional material, structurally derived from dufulin, inherit progenitor's systemic and conductive properties, alongside the capacity to activate salicylic acid-mediated plant defense pathways. Moreover, it is endowed with the anticipated abilities to disorganize biofilm barriers, annihilate encased pathogens, and inhibit T3SS. This constitutes the inaugural report of a supramolecular-based biofilm/T3SS dual inhibitor. An expanded investigation into substrate and indication screening identified additional molecules that self-assemble with β -cyclodextrin to form supramolecular materials, exhibiting superior potency against other rice diseases, with protective potency ranging from 63.53% to 73.30% and curative efficacy spanning 42.18% to 60.41% at 200 µg mL −1 . In brief, this work establishes a paradigm for designing guest molecules from scratch to construct supramolecular materials with tailored characteristics.}, archive = {J_ADVS}, author = {Xianfu Mu and Kongjun Liu and Jinghan Yang and Juan Liu and Fengpei Du and Gefei Hao and Peiyi Wang}, doi = {10.1002/advs.202410878}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410878}, shortjournal = {Adv. Sci.}, title = {From de novo conceived small molecules to multifunctional supramolecular nanoparticles: Dual biofilm and T3SS intervention, enhanced foliar affinity, and effective rice disease control}, volume = {12}, year = {2025}, }
• (2025). The GhWL1-GhH1-GhGA2OX1 transcriptional module regulates cotton leaf morphology. ADVS, 12(20), 2410783. (www)

  @article{ , abstract = {Leaf morphology critically influences photosynthetic efficiency, directly affecting crop yield and quality. In this study, a T-DNA insertion mutant ( wl-D ), characterized by a wrinkled-leaf phenotype, is identified. Genetic analysis reveals that this phenotype is governed by a single dominant gene, WRINKLED-LEAF 1 (GhWL1) , which is highly expressed in wl-D compared to the wild type (WT). Overexpression of GhWL1 in WT caused curling at leaf edges, while suppression of GhWL1 in wl-D restored normal leaf morphology, validating its functional role. Further analysis demonstrated that GhWL1 interacts with GhH1 , a protein with a KNOX1 structural domain, to regulate leaf development. Overexpression of GhH1 in WT results in a leaf shrinkage phenotype similar to wl-D , whereas suppressing GhH1 in wl-D restored normal leaf morphology, indicating that GhH1 acts downstream of GhWL1 . The GhWL1-GhH1 complex directly binds to the promoter of GhGA2OX1 (gibberellin 2-beta-dioxygenase 1), positively regulating its expression. Overexpression of GhGA2OX1 in WT mimicked the leaf shrinkage phenotype observed in plants overexpressing GhH1 . These findings establish the GhWL1-GhH1 -GhGA2OX1 module as a critical pathway in regulating leaf development, offering valuable insights into the genetic and hormonal networks controlling leaf morphological diversity.}, archive = {J_ADVS}, author = {Jingjing Zhan and Xiaoshuang Zhang and Ye Wang and Hang Zhao and Yu Chu and Peng Wang and Yanli Chen and Xi Wei and Wenqiang Qin and Menghan Liu and Jie Kong and Fuguang Li and Xiaoyang Ge}, doi = {10.1002/advs.202410783}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410783}, shortjournal = {Adv. Sci.}, title = {The GhWL1-GhH1-GhGA2OX1 transcriptional module regulates cotton leaf morphology}, volume = {12}, year = {2025}, }
• (2025). A multi-objective molecular generation method based on pareto algorithm and monte carlo tree search. ADVS, 12(20), 2410640. (www)

  @article{ , abstract = {Drug discovery faces increasing challenges in identifying novel drug candidates satisfying multiple stringent objectives, such as binding affinity, protein target selectivity, and drug-likeness. Existing optimization methods struggle with the complexity of handling numerous objectives, limiting advancements in molecular design as most algorithms are only effective for up to four optimization objectives. To overcome these limitations, the study introduces the Pareto Monte Carlo Tree Search Molecular Generation (PMMG) method, leveraging Monte Carlo Tree Search (MCTS) to efficiently uncover the Pareto Front for molecular design tasks in high-dimensional objective space. By utilizing simplified molecular input line entry system (SMILES) to represent molecules, PMMG efficiently navigates the vast chemical space to discover molecules that exhibit multiple desirable attributes simultaneously. Numerical experiments demonstrate PMMG's superior performance, achieving a remarkable success rate of 51.65% in simultaneously optimizing seven objectives, outperforming current state-of-the-art algorithms by 2.5 times. An illustrative study targeting Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor 2 (HER2) highlights PMMG's ability to generate molecules with high docking scores for target proteins and favorable predicted drug-like properties. The results suggest that PMMG has the potential to significantly accelerate real-world drug discovery projects involving numerous optimization objectives.}, archive = {J_ADVS}, author = {Yifei Liu and Yiheng Zhu and Jike Wang and Renling Hu and Chao Shen and Wanglin Qu and Gaoang Wang and Qun Su and Yuchen Zhu and Yu Kang and Peichen Pan and Chang-Yu Hsieh and Tingjun Hou}, doi = {10.1002/advs.202410640}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410640}, shortjournal = {Adv. Sci.}, title = {A multi-objective molecular generation method based on pareto algorithm and monte carlo tree search}, volume = {12}, year = {2025}, }
• (2025). Nanocrystal compressive residual stresses: A strategy to strengthen the bony spines of osteocytic and anosteocytic fish. ADVS, 12(20), 2410617. (www)

  @article{ , abstract = {Bone is a living tissue in which communicating cells, osteocytes, are assumed to be vital for tissue turnover and adaptation. Interestingly however, most advanced teleost fish do not possess osteocyte-mediated porosity, prompting intriguing questions about alternative material-strategies for these bones to cope with damage. Using advanced imaging techniques, including phase-contrast enhanced (PCE) microtomography (µCT) and nanotomography (nanoCT), X-ray fluorescence (XRF), and diffraction (XRD) tomography, the micro- and nano-architectures of osteocytic zebrafish are compared with anosteocytic medaka fishbone. PCE µCT and Zernike phase-contrast nanoCT showed a lack of porosity in medaka bone and 0.75 – 2.26% osteocytic porosity in zebrafish. Both fish species have similar mineralized collagen fibril arrangements containing calcium (Ca) and traces of strontium (Sr) with increased zinc (Zn) localized on the outer bone regions. Medaka bones exhibit reduced apatite nanocrystal lattice spacings on the outer surfaces. Indeed we find higher compressive residual strains (-0.100 ± 0.02) compared to zebrafish (-0.071 ± 0.03). We propose that medaka bone evolved to replace the mechanosensitive osteocytic network by entrapping protective residual strains between collagen nanofibers and mineral crystals. These strains may enhance fracture toughness while making this nanocomposite well-suited for sustaining repeated loading cycles, thus reducing the metabolic costs associated with housing a large network of cells.}, archive = {J_ADVS}, author = {Andreia Silveira and Anton Davydok and Christina Krywka and Mario Scheel and Timm Weitkamp and Claudia Fleck and Ron Shahar and Paul Zaslansky}, doi = {10.1002/advs.202410617}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410617}, shortjournal = {Adv. Sci.}, title = {Nanocrystal compressive residual stresses: A strategy to strengthen the bony spines of osteocytic and anosteocytic fish}, volume = {12}, year = {2025}, }
• (2025). Conjugated lithocholic acid activates hepatic TGR5 to promote lipotoxicity and MASLD-MASH transition by disrupting carnitine biosynthesis. ADVS, 12(20), 2410602. (www)

  @article{ , abstract = {Conjugated lithocholic acid (LCA) plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). In this process, hepatocyte inflammation-caused upregulation of its receptor, Takeda G protein-coupled receptor 5 (TGR5) is a crucial factor. Serum bile acid profiling shows an increase in conjugated LCA, which correlates with disease severity. Depletion of Gpbar1 in hepatocytes significantly protects against the progression from MASLD to metabolic dysfunction-associated steatohepatitis (MASH) that is related to conjugated LCA. In vivo and in vitro experiments indicate that TGR5 activation in hepatocytes promotes lipotoxicity-induced cell death and inflammation by suppressing de novo carnitine biosynthesis. Mechanistically, TGR5 binding to CD36 facilitates E3 ubiquitin ligase TRIM21 recruitment, leading to the degradation of BBOX1, a crucial enzyme in de novo carnitine biosynthesis. Targeting TGR5 therapeutically can restore carnitine biosynthesis, which may offer a potent strategy to prevent or reverse the transition from MASLD to MASH.}, archive = {J_ADVS}, author = {Senlin Lian and Meixi Lu and Luo Jiajing and Bin Zhang and Yi Fang and Xuran Wang and Minghua Zheng and Yan Ni and Guifang Xu and Yonglin Yang and Runqiu Jiang}, doi = {10.1002/advs.202410602}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410602}, shortjournal = {Adv. Sci.}, title = {Conjugated lithocholic acid activates hepatic TGR5 to promote lipotoxicity and MASLD-MASH transition by disrupting carnitine biosynthesis}, volume = {12}, year = {2025}, }
• (2025). CircRNA-mTOR promotes hepatocellular carcinoma progression and lenvatinib resistance through the PSIP1/c-myc axis. ADVS, 12(20), 2410591. (www)

  @article{ , abstract = {Circular RNAs (circRNAs) are crucial regulators of targeted drug resistance in hepatocellular carcinoma (HCC). However, the specific mechanisms underlying resistance that significantly hampers the effectiveness of HCC treatments remain unclear. Here, it is found that circRNA-mTOR is highly expressed in HCC and strongly correlated with patient prognosis. Furthermore, circRNA-mTOR enhances the stemness of HCC cells, thereby promoting the progression of HCC and contributing to lenvatinib resistance. Mechanistically, circRNA-mTOR promotes the nuclear translocation of the RNA-binding protein (RBP) PC4 and SRSF1 interacting protein 1 (PSIP1) through specific binding. The enhancement of HCC cell stemness by circRNA-mTOR occurs via the PSIP1/c-Myc signaling pathway, ultimately driving HCC progression and lenvatinib resistance. This study highlights the important role of circRNA-mTOR in HCC progression and the maintenance of lenvatinib resistance and underscores its potential as a biomarker for the diagnosis and prognosis of HCC. In conclusion, this study provides an experimental foundation for targeted drug therapy in HCC and offers novel insights, perspectives, and methodologies for understanding the development and occurrence of this disease. These findings are significant for the development of new diagnostic and therapeutic markers for HCC, with the ultimate goal of reducing drug resistance.}, archive = {J_ADVS}, author = {Yongchang Tang and Feng Yuan and Mingbo Cao and Yupeng Ren and Yuxuan Li and Gaoyuan Yang and Zhaozhong Zhong and Hao Liang and Zhiyong Xiong and Zhiwei He and Nan Lin and Meihai Deng and Zhicheng Yao}, doi = {10.1002/advs.202410591}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410591}, shortjournal = {Adv. Sci.}, title = {CircRNA-mTOR promotes hepatocellular carcinoma progression and lenvatinib resistance through the PSIP1/c-myc axis}, volume = {12}, year = {2025}, }
• (2025). Immunity debt for seasonal influenza after the COVID-19 pandemic and as a result of nonpharmaceutical interventions: An ecological analysis and cohort study. ADVS, 12(20), 2410513. (www)

  @article{ , abstract = {Non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic significantly reduced influenza transmission. This study explores the hypothesis of “immunity debt” which suggests increased vulnerability to influenza following reduced exposure during the pandemic. World Health Organization aggregated data on influenza from 116 countries and its association with NPI intensity as measured by the COVID-19 Stringency Index is analyzed. Where individual-level data available (France, the United Kingdom, Spain, Italy, Belgium, and Romania), the analyses of influenza monthly rates in six European countries (France, the United Kingdom, Spain, Italy, Belgium, and Romania) are replicated. The results indicate globally a 46.3% (95% CI: 15.79–70.78%) reduction in influenza cases during COVID-19 restrictions in the winter season, followed by a 131.7% (95% CI: 34.95–255.78%) increase in the first postrelaxation winter and a 161.2% (95% CI: 31.88–382.16%) increase in the summer as compared to the predicted level based on historical influenza epidemic trends. In addition, a positive association between the Stringency Index and post-relaxation influenza surge is observed globally (R 2 = 0.14–0.17) and replicated regionally. The findings support the population immunity debt hypothesis for influenza and call for proactive preparations against its consequences in future pandemics.}, archive = {J_ADVS}, author = {Li Chen and Yuchen Guo and Kim López-Güell and Jun Ma and Yanhui Dong and Junqing Xie and Daniel Prieto Alhambra}, doi = {10.1002/advs.202410513}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410513}, shortjournal = {Adv. Sci.}, title = {Immunity debt for seasonal influenza after the COVID-19 pandemic and as a result of nonpharmaceutical interventions: An ecological analysis and cohort study}, volume = {12}, year = {2025}, }
• (2025). Lightweight 3D hierarchical metamaterial microlattices. ADVS, 12(20), 2410293. (www)

  @article{ , abstract = {Hierarchical auxetic metamaterials are a class of materials which are characterized by a multi-tiered architecture and have the capability of exhibiting enhanced mechanical properties in comparison to their single-geometry counterparts. In this work, three distinct new classes of hierarchical auxetic metamaterials designed by incorporating cubic crystal lattice geometries, namely, Body-Centred Cubic (BCC), Face-Centred Cubic (FCC) and Tetrahedral Cubic (TC) are proposed into 3D rotating cube structures. Through the introduction of hierarchy, these relatively dense mechanical metamaterials are rendered lightweight, through a volume fraction reduction of over 90% in the majority of cases from their full-block (FB) counterparts, while retaining their original auxetic capabilities. These systems are also demonstrated to possess the ability to exhibit a wide range of stiffnesses and Poisson's ratios, including giant negative values, as well as superior stiffness/density ratios making them ideal for implementation in lightweight applications. Furthermore, a two-photon lithography 3D-printer is used to fabricate these new lattice structures at the microscale and test them in-situ. The results obtained provide clear and comprehensive evidence of the improvement imparted through the introduction of hierarchy and the advantages of using this method to design lightweight 3D rotating unit auxetic structures.}, archive = {J_ADVS}, author = {Luke Mizzi and Krzysztof K. Dudek and Andrea Frassineti and Andrea Spaggiari and Gwenn Ulliac and Muamer Kadic}, doi = {10.1002/advs.202410293}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2410293}, shortjournal = {Adv. Sci.}, title = {Lightweight 3D hierarchical metamaterial microlattices}, volume = {12}, year = {2025}, }
• (2025). Unveiling structural heterogeneity and evolutionary adaptations of heteromultimeric bacterioferritin nanocages. ADVS, 12(20), 2409957. (www)

  @article{ , abstract = {Iron-storage bacterioferritins (Bfrs), existing in either homo- or hetero-multimeric form, play a crucial role in iron homeostasis. While the structure and function of homo-multimeric bacterioferritins (homo-Bfrs) have been extensively studied, little is known about the assembly, distinctive characteristics, or evolutionary adaptations of hetero-multimeric bacterioferritins (hetero-Bfrs). Here, the cryo-EM structure and functional characterization of a bacterial hetero-Bfr ( So Bfr12) are reported. Compared to homo-Bfrs, although So Bfr12 exhibits a conserved spherical cage-like dodecahedron, its pores through which ions traverse exhibit substantially increased diversity. Importantly, the heterogeneity has significant impacts on sites for ion entry, iron oxidation, and reduction. Moreover, evolutionary analyses reveal that hetero-Bfrs may represent a new class within the Bfr subfamily, consisting of two different types that may have evolved from homo-Bfr through tandem duplication and directly from ferritin (Ftn) via dispersed duplication, respectively. These results reveal remarkable structural and functional features of a hetero-Bfr, enabling the rational design of nanocages for enhanced iron-storing efficiency and for other specific purposes, such as drug delivery vehicles and nanozymes.}, archive = {J_ADVS}, author = {Yingxi Li and Weiwei Wang and Wei Wang and Xing Zhang and Jinghua Chen and Haichun Gao}, doi = {10.1002/advs.202409957}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2409957}, shortjournal = {Adv. Sci.}, title = {Unveiling structural heterogeneity and evolutionary adaptations of heteromultimeric bacterioferritin nanocages}, volume = {12}, year = {2025}, }
• (2025). Microbiota-derived inosine suppresses systemic autoimmunity via restriction of b cell differentiation and migration. ADVS, 12(20), 2409837. (www)

  @article{ , abstract = {The role of gut microbiota dysbiosis in systemic lupus erythematosus (SLE) pathogenesis remains elusive. Here, it is shown that fecal microbiota transplantation (FMT) from healthy mice to lupus mice ameliorates lupus-like symptoms. Microbiota reconstitution effectively reduces systemic class switch recombination (CSR) and elevates immunoglobulin heavy chain (IGH) naïve isotype. Microbiota profiling reveals an enrichment of Lactobacillus johnsonii post-FMT, with a significant correlation to purine metabolites. Importantly, the L. johnsonii -derived inosine, an intermediate metabolite in purine metabolism, effectively alleviates lupus pathogenesis in mice. Inosine inhibits B cell differentiation and reduces renal B cell infiltration to protect mice from lupus. At the molecular level, inosine reprograms B cells through the extracellular signal-regulated kinase (ERK)-hypoxia-inducible factor-1alpha (HIF-1α) signaling pathway. Therefore, this study highlights the discovery of a novel microbial metabolite modulating autoimmunity and suggests its potential for innovative microbiome-based therapeutic approaches.}, archive = {J_ADVS}, author = {Lingyu Gao and Yuhan Zhang and Zhi Hu and Shengwen Chen and Qiaolin Wang and Yong Zeng and Huiqi Yin and Junpeng Zhao and Yijing Zhan and Changxing Gao and Yue Xin and Bing Chen and Stijn van der Veen and Ming Zhao and Deyu Fang and Qianjin Lu}, doi = {10.1002/advs.202409837}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2409837}, shortjournal = {Adv. Sci.}, title = {Microbiota-derived inosine suppresses systemic autoimmunity via restriction of b cell differentiation and migration}, volume = {12}, year = {2025}, }
• (2025). Machine learning-based radiomics in malignancy prediction of pancreatic cystic lesions: Evidence from cyst fluid multi-omics. ADVS, 12(20), 2409488. (www)

  @article{ , abstract = {The malignant potential of pancreatic cystic lesions (PCLs) varies dramatically, leading to difficulties when making clinical decisions. This study aimed to develop noninvasive clinical-radiomic models using preoperative CT images to predict the malignant potential of PCLs. It also investigates the biological mechanisms underlying these models. Patients from two retrospective and one prospective cohort, all undergoing surgical resection for PCLs, are divided into four datasets: training, internal test, external test, and prospective application sets. Eleven machine learning classifiers are employed to construct radiomic models based on selected features. Cyst fluid from the prospective cohort is collected for proteomic and lipidomic analysis. The radiomic models demonstrated high accuracy, with area under the receiver operating characteristic curves (AUCs) > 0.93 across the training (n = 262), internal test (n = 50), and external test (n = 50) sets. AUCs ranged from 0.92 to 0.96 for the prospective cohort (n = 34). Meanwhile, differentially-expressed proteins and lipid molecules, along with their associated signaling pathways, are identified between high and low groups of clinical-radiomic scores. This models can effectively and accurately predict the malignant potential of PCLs, with multi-omics evidence suggesting the biological mechanisms involving secretion function and lipid metabolism underlying clinical-radiomic models.}, archive = {J_ADVS}, author = {Sihang Cheng and Ge Hu and Shenbo Zhang and Rui Lv and Limeng Sun and Zhe Zhang and Zhengyu Jin and Yanyan Wu and Chen Huang and Lu Ye and Yunlu Feng and Zhe-Sheng Chen and Zhiwei Wang and Huadan Xue and Aiming Yang}, doi = {10.1002/advs.202409488}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2409488}, shortjournal = {Adv. Sci.}, title = {Machine learning-based radiomics in malignancy prediction of pancreatic cystic lesions: Evidence from cyst fluid multi-omics}, volume = {12}, year = {2025}, }
• (2025). In-depth cell-type-specific proteome landscape of the brain from human amyloid-β overexpression mouse model. ADVS, 12(20), 2409318. (www)

  @article{ , abstract = {Amyloid-β (Aβ) plays a crucial role in Alzheimer's disease pathogenesis. Understanding how Aβ overexpression alters the proteome of individual brain cell types is essential but challenging due to the nature of brain tissue, which contains intermingled various cell types. The current methods for cell-type-specific proteomics either require genetic modifications or complex cell isolation, limiting their use. This study introduces a novel method, in situ cell-type-specific proteome analysis using antibody-mediated biotinylation (iCAB), which applies immunohistochemistry with biotin-tyramide to target cell-specific proteins directly in tissue. Applied to 5xFAD mice, iCAB enables us to identify ≈8000 cell-type-specific proteomes with significantly more differentially expressed proteins than traditional bulk proteome methods, pinpointing unique pathways such as mRNA processing, calcium regulation, and phagocytosis for neurons, astrocytes, and microglia, respectively. This study reports in-depth the cell-type-specific brain proteome landscape of the human Aβ overexpression mouse model for the first time using an innovative tool that is powerful, straightforward, and applicable to both animal models and human tissues, without the need for prior genetic alterations.}, archive = {J_ADVS}, author = {Taekyung Ryu and Seok-Young Kim and Thujitha Thuraisamy and Jisu Shin and Yura Jang and Tae-In Kam and Chan Hyun Na}, doi = {10.1002/advs.202409318}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2409318}, shortjournal = {Adv. Sci.}, title = {In-depth cell-type-specific proteome landscape of the brain from human amyloid-β overexpression mouse model}, volume = {12}, year = {2025}, }
• (2025). ZMYND8 reads H3K36me2 to activate CEBPE transcription and suppress multiple myeloma progression through the inhibition of adaptive UPR pathways. ADVS, 12(20), 2409219. (www)

  @article{ , abstract = {Multiple myeloma (MM) pathogenesis is closely associated with aberrant epigenetic regulation and resulting modifications, such as dimethylation of lysine 36 in histone H3 (H3K36me2). However, the recognition signature of H3K36me2 and its functional role in MM remain largely unknown. Here, the zinc-finger MYND-type-containing 8 (ZMYND8) is identified as a potential reader of the H3K36me2 mark that suppresses MM progression. ZMYND8 knockdown promotes the proliferation and invasion of MM cells. Combined transcriptomic and epigenomic analyses reveal that CCAAT/enhancer-binding protein epsilon (CEBPE) is a direct downstream target of ZMYND8. CEBPE modulates adaptive unfolded protein response (UPR) pathways through the transcriptional repression of ERN1, XBP1, and ATF6 to impair cell survival. Coimmunoprecipitation and chromatin immunoprecipitation assays show that ZMYND8 activates CEBPE expression in an H3K36me2-dependent manner and that its Pro-Trp-Trp-Pro domain is required for binding H3K36me2 modules, leading to CEBPE transcription. Low ZMYND8 expression is significantly correlated with adverse clinicopathological features and poor survival outcomes in MM patients. Furthermore, ZMYND8 upregulation increases the sensitivity of MM cells to carfilzomib. Taken together, these findings demonstrate that ZMYND8 epigenetically activates CEBPE transcription and suppresses MM cell growth by inhibiting the adaptive UPR, suggesting that ZMYND8 can be a novel therapeutic target for patients with MM.}, archive = {J_ADVS}, author = {Jiaxuan Xu and Xiaoqing Dong and Yue Peng and Jie Yan and Peipei Xu and Feiyu Li and Suwen Zhang and Lanxin Chen and Xingjun Meng and Kangning Wang and Mengying Xing and Wenyang Li and David C. S. Huang and Quan Zhao and Bing Chen}, doi = {10.1002/advs.202409219}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2409219}, shortjournal = {Adv. Sci.}, title = {ZMYND8 reads H3K36me2 to activate CEBPE transcription and suppress multiple myeloma progression through the inhibition of adaptive UPR pathways}, volume = {12}, year = {2025}, }
• (2025). A membrane magnetoelastic generator for acoustic energy harvesting. ADVS, 12(20), 2409063. (www)

  @article{ , abstract = {Acoustic waves are a type of energy propagation through a medium with a low energy density, which makes it challenging to be converted into electricity. Here, a membrane magnetoelastic generator is presented as a fundamentally new technology for acoustic energy harvesting that is centered on a coupling of magnetoelastic effect and electromagnetic induction. It is as thin as 400 µm, holds a skin-alike modulus of 2.59 × 10 7 Pa, a low internal impedance of 137 Ω, and a high current density of 107 mA m⁻ 2 at a sound pressure level (SPL) of 95 dB. It can efficiently harvest acoustic energy to charge a 47 µF commercial capacitor to 2 V in 20 s. With an all-in-one-body design, the membrane magnetoelastic generator shows stable electrical output against environmental moisture and particulates. Toward practical application, it is demonstrated to harvest acoustic energy from a vehicle stereo and use recycled energy to charge a smartphone. Its inherent water-/dust-proof features open new possibilities for acoustic energy harvesting from city buildings, highways, airplanes, and even battlefields.}, archive = {J_ADVS}, author = {Ziyuan Che and Jing Xu and Xiao Wan and Chrystal Duan and Jun Chen}, doi = {10.1002/advs.202409063}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2409063}, shortjournal = {Adv. Sci.}, title = {A membrane magnetoelastic generator for acoustic energy harvesting}, volume = {12}, year = {2025}, }
• (2025). α-synuclein pathology spreads in a Midbrain–Hindbrain assembloid model. ADVS, 12(20), 2409040. (www)

  @article{ , abstract = {Understanding the progression of α-synuclein pathology in neurodegenerative diseases such as Parkinson's disease (PD) is a longstanding challenge. Here, a novel midbrain–hindbrain-assembloid model that recapitulates the spread of α-synuclein pathology observed in PD patients, akin to Braak's hypothesis, is presented. Initially, the presence α-synuclein pathology is demonstrated in the hindbrain organoids. Subsequently, sophisticated tissue engineering methods are employed to create midbrain–hindbrain assembloids. These assembloids allow investigation and description of the spreading of α-synuclein pathology, as it progresses from the hindbrain components to the midbrain regions within the integrated structure. It is observed that an increase in α-synuclein in the hindbrain can induce transfer of the pathology into the healthy midbrain, as well as cause changes at the synapse level. The presented model constitutes a robust in vitro platform for investigating the mechanisms underlying α-synuclein spreading and disease progression, and holding potential for the screening of prospective therapeutics targeting the pathological propagation in PD and related synucleinopathies.}, archive = {J_ADVS}, author = {Gemma Gomez-Giro and Daniela Frangenberg and Daniela Vega and Alise Zagare and Kyriaki Barmpa and Paul M. A. Antony and Graham Robertson and Rahman Sabahi-Kaviani and Kristian Haendler and Nathalie Kruse and Florentia Papastefanaki and Rebecca Matsas and Malte Spielmann and Regina Luttge and Jens C. Schwamborn}, doi = {10.1002/advs.202409040}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2409040}, shortjournal = {Adv. Sci.}, title = {α-synuclein pathology spreads in a Midbrain–Hindbrain assembloid model}, volume = {12}, year = {2025}, }
• (2025). PCSK9 promotes the malignancy of triple-negative breast cancer cells by reducing cholesterol levels at the plasma membrane to activate EGFR and HER3. ADVS, 12(20), 2408514. (www)

  @article{ , abstract = {Triple-negative breast cancer (TNBC) is a highly heterogeneous and clinically aggressive disease with the highest mortality rate among all subtypes of breast cancer. To discover new driver genes for metastatic TNBC, this work compares the transcription profiles of MDA-MB-231-GFP cells and 231-GFP-derived lung metastatic cells (4–11). Results reveal that proprotein convertase subtilisin/kexin type 9 (PCSK9) is highly upregulated in 4–11 cells. Knockdown of PCSK9 greatly decreases the tumorigenic and metastatic potential of 4–11 cells, whereas overexpression of PCSK9 significantly enhances tumor maliganancy. Mechanistically, the binding of PCSK9 to the low-density lipoprotein receptor (LDLR) results in decreased LDLR at the plasma membrane, which further decreases cholesterol and lipid raft in the plasma membrane and activates human epidermal growth factor receptor 1 and 3 (EGFR and HER3). Subsequently, phosphorylated EGFR and HER3 activate the Src/ERK/c-Jun to increase the levels of cyclin D3 and vimentin and thereby enhance cell growth and metastasis. Metadata analyses also reveal that TNBC patients with high PCSK9 expression exhibited worse clinical outcomes. Taken together, these findings not only reveal a novel mechanism by which PCSK9 promotes the malignant potential of TNBC but also indicate that PCSK9 is a potential therapeutic target for treating TNBC patients.}, archive = {J_ADVS}, author = {Tianhong Li and Renfei Wu and Kathy Qian Luo}, doi = {10.1002/advs.202408514}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2408514}, shortjournal = {Adv. Sci.}, title = {PCSK9 promotes the malignancy of triple-negative breast cancer cells by reducing cholesterol levels at the plasma membrane to activate EGFR and HER3}, volume = {12}, year = {2025}, }
• (2025). Iron deficiency impairs dendritic cell development and function, compromising host anti-infection capacity. ADVS, 12(20), 2408348. (www)

  @article{ , abstract = {The prevalence of acute lower respiratory infections in individuals with iron deficiency (ID) has significantly increased, and is correlated with reduced numbers of immune cells and impaired immune function. Dendritic cells (DCs) play a crucial role in combating the influenza A virus (IAV) by initiating adaptive immune responses. However, the impact of ID on DCs and their response to IAV infection remain unclear. This study showed that ID impairs the antigen-presenting ability of DCs, thereby hindering their capacity to mediate T-cell proliferation and clear viruses. The restrictive effects of ID on DCs begin in the bone marrow and specifically affect the monocyte DC progenitor (MDP) stage. A reduction in the number of MDPs and compromised immune potential lead to a decrease in the population and functionality of DCs in the subsequent common DC precursor (CDP) stage in the blood, spleen, and lungs. This study highlights the previously unrecognized impact of ID on DCs and provides valuable insights into immune cell responses and the application of iron supplementation in the fight against viral infections.}, archive = {J_ADVS}, author = {Quanzhong Ren and Xiaotong Xu and Zheng Dong and Jiahuang Qiu and Qing'e Shan and Rui Chen and Yajun Liu and Juan Ma and Sijin Liu}, doi = {10.1002/advs.202408348}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2408348}, shortjournal = {Adv. Sci.}, title = {Iron deficiency impairs dendritic cell development and function, compromising host anti-infection capacity}, volume = {12}, year = {2025}, }
• (2025). RNF112 facilitates ubiquitin-mediated degradation of c-myc, suppressing proliferation, migration and lipid synthesis in bladder cancer. ADVS, 12(20), 2408311. (www)

  @article{ , abstract = {The E3 ubiquitin ligase RNF112 is significantly downregulated in bladder cancer (BLCA) and is correlated with disease progression. In vitro and in vivo studies indicated that RNF112 suppresses BLCA cell proliferation, migration, and lipid synthesis. Mechanistically, RNF112 directly interacts with the MB II domain of MYC through its N-terminal zinc finger motif, and its catalytic site C97 facilitates K48-linked polyubiquitination of the K389 residue on the c-Myc protein, accelerating its degradation. Additionally, this research validated the interaction of c-Myc with the promoter of ATP citrate lyase ( ACLY ), a central enzyme of lipid metabolism, promoting its transcriptional activity. The restoration of c-Myc or ACLY expression attenuated the inhibitory effects of RNF112 on BLCA cell growth, migration, and lipid synthesis. In conclusion, this study confirmed that RNF112 suppressed the proliferation, migration, and lipid synthesis of BLCA cells by facilitating the ubiquitin-mediated degradation of c-Myc.}, archive = {J_ADVS}, author = {Kangping Xiong and Siming Chen and Huimin Xu and Sheng Tu and Hong Weng and Yejinpeng Wang and Mingxing Li and Jingtian Yu and Kaiyu Qian and Lingao Ju and Yi Zhang and Yu Xiao and Xinghuan Wang and Gang Wang}, doi = {10.1002/advs.202408311}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2408311}, shortjournal = {Adv. Sci.}, title = {RNF112 facilitates ubiquitin-mediated degradation of c-myc, suppressing proliferation, migration and lipid synthesis in bladder cancer}, volume = {12}, year = {2025}, }
• (2025). Ultralow-dimensionality reduction for identifying critical transitions by spatial-temporal PCA. ADVS, 12(20), 2408173. (www)

  @article{ , abstract = {Discovering dominant patterns and exploring dynamic behaviors especially critical state transitions and tipping points in high-dimensional time-series data are challenging tasks in study of real-world complex systems, which demand interpretable data representations to facilitate comprehension of both spatial and temporal information within the original data space. This study proposes a general and analytical ultralow-dimensionality reduction method for dynamical systems named spatial-temporal principal component analysis (stPCA) to fully represent the dynamics of a high-dimensional time-series by only a single latent variable without distortion, which transforms high-dimensional spatial information into one-dimensional temporal information based on nonlinear delay-embedding theory. The dynamics of this single variable is analytically solved and theoretically preserves the temporal property of original high-dimensional time-series, thereby accurately and reliably identifying the tipping point before an upcoming critical transition. Its applications to real-world datasets such as individual-specific heterogeneous ICU records demonstrate the effectiveness of stPCA, which quantitatively and robustly provides the early-warning signals of the critical/tipping state on each patient.}, archive = {J_ADVS}, author = {Pei Chen and Yaofang Suo and Kazuyuki Aihara and Ye Li and Dan Wu and Rui Liu and Luonan Chen}, doi = {10.1002/advs.202408173}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2408173}, shortjournal = {Adv. Sci.}, title = {Ultralow-dimensionality reduction for identifying critical transitions by spatial-temporal PCA}, volume = {12}, year = {2025}, }
• (2025). Bioprinted patient-derived organoid arrays capture intrinsic and extrinsic tumor features for advanced personalized medicine. ADVS, 12(20), 2407871. (www)

  @article{ , abstract = {Heterogeneity and the absence of a tumor microenvironment (TME) in traditional patient-derived organoid (PDO) cultures limit their effectiveness for clinical use. Here, Embedded Bioprinting-enabled Arrayed PDOs (Eba-PDOs) featuring uniformly arrayed colorectal cancer (CRC) PDOs within a recreated TME is presented. This model faithfully reproduces critical TME attributes, including elevated matrix stiffness (≈7.5 kPa) and hypoxic conditions found in CRC. Transcriptomic and immunofluorescence microscopy analysis reveal that Eba-PDOs more accurately represent actual tissues compared to traditional PDOs. Furthermore, Eba-PDO effectively capture the variability of CEACAM5 expression—a critical CRC marker—across different patients, correlating with patient classification and differential responses to 5-fluorouracil treatment. This method achieves an uniform size and shape within PDOs from the same patient while preserving distinct morphological features among those from different individuals. These features of Eba-PDO enable the efficient development of a label-free, morphology-based predictive model using supervised learning, enhancing its suitability for clinical applications. Thus, this approach to PDO bioprinting is a promising tool for generating personalized tumor models and advancing precision medicine.}, archive = {J_ADVS}, author = {Jonghyeuk Han and Hye-Jin Jeong and Jeonghan Choi and Hyeonseo Kim and Taejoon Kwon and Kyungjae Myung and Kyemyung Park and Jung In Park and Samuel Sánchez and Deok-Beom Jung and Chang Sik Yu and In Ho Song and Jin-Hyung Shim and Seung-Jae Myung and Hyun-Wook Kang and Tae-Eun Park}, doi = {10.1002/advs.202407871}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2407871}, shortjournal = {Adv. Sci.}, title = {Bioprinted patient-derived organoid arrays capture intrinsic and extrinsic tumor features for advanced personalized medicine}, volume = {12}, year = {2025}, }
• (2025). Malignant hepatoblast-like cells sustain stemness via IGF2-dependent cholesterol accumulation in hepatoblastoma. ADVS, 12(20), 2407671. (www)

  @article{ , abstract = {Hepatoblastoma, the most aggressive childhood liver tumor, poses significant challenges due to limited knowledge of its pathogenesis, particularly in poorly differentiated advanced tumors where the prognosis is dismal. Single-cell sequencing provides an in-depth exploration at the single-cell level and offers a deep understanding of tumor heterogeneity. Herein, single-cell transcriptomics analysis is used to identify a unique malignant-hepatoblast (HB)-like cell subpopulation as the possible origin of poorly differentiated hepatoblastoma. These cells are associated with an unfavorable clinical prognosis in hepatoblastoma patients. The malignant-HB-like cell subpopulation generated insulin-like growth factor 2 (IGF2) to sustain stem-like features by promoting abnormal cholesterol accumulation via SREBF2. IGF2 also stimulated fibroblast 2 to secrete collagen 1, intensifying tumor malignancy via the collagen 1/integrin α1 signaling pathway. This suggests that targeting malignant HB-like cells by inhibiting IGF2-induced pathways can lead to promising treatments for hepatoblastoma. Additionally, serum IGF2 levels may serve as a diagnostic biomarker for advanced hepatoblastoma. In summary, these findings provide valuable insight into the genesis and malignancy of hepatoblastoma and a foundation for more effective diagnostic tools and therapeutic strategies for this challenging disease.}, archive = {J_ADVS}, author = {Miao Ding and Siwei Mao and Han Wu and Sijia Fang and Ni Zhen and Tianshu Chen and Jiabei Zhu and Xiaochen Tang and Xiaoyang Wang and Fenyong Sun and Guoqing Zhu and Qiuhui Pan and Ji Ma}, doi = {10.1002/advs.202407671}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2407671}, shortjournal = {Adv. Sci.}, title = {Malignant hepatoblast-like cells sustain stemness via IGF2-dependent cholesterol accumulation in hepatoblastoma}, volume = {12}, year = {2025}, }
• (2025). NaBC1 boron transporter enables myoblast response to substrate rigidity via fibronectin-binding integrins. ADVS, 12(20), 2407548. (www)

  @article{ , abstract = {Cells are sensitive to the physical properties of their microenvironment and transduce them into biochemical cues that trigger gene expression and alter cell behavior. Numerous proteins, including integrins, are involved in these mechanotransductive events. Here, a novel role for the boron transporter NaBC1 is identified as a mechanotransducer. It is demonstrated that soluble boron ions activate NaBC1 to enhance cell adhesion and intracellular tension in C2C12 myoblasts seeded on fibronectin-functionalized polyacrylamide (PAAm) hydrogels. Retrograde actin flow and traction forces exerted by these cells are significantly increased in vitro in response to both increased boron concentration and hydrogel stiffness. These effects are fibronectin and NaBC1-mediated as they are abrogated in hydrogels coated with laminin-111 in place of fibronectin and in esiRNA NaBC1-silenced cells. These findings thus demonstrate that NaBC1 controls boron homeostasis and also functions as a mechanosensor.}, archive = {J_ADVS}, author = {Juan Gonzalez-Valdivieso and Giuseppe Ciccone and Udesh Dhawan and Tezz Quon and Eva Barcelona-Estaje and Aleixandre Rodrigo-Navarro and Rafael R. Castillo and Graeme Milligan and Patricia Rico and Manuel Salmeron-Sanchez}, doi = {10.1002/advs.202407548}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2407548}, shortjournal = {Adv. Sci.}, title = {NaBC1 boron transporter enables myoblast response to substrate rigidity via fibronectin-binding integrins}, volume = {12}, year = {2025}, }
• (2025). Trait-based life history strategies shape bacterial niche breadth. ADVS, 12(20), 2405947. (www)

  @article{ , abstract = {The ecological niche represents a fundamental property of organisms, reflecting their diversity of utilized resources or environmental tolerances across space and time. Despite a wealth of studies revealing that not all bacteria being everywhere, the key traits that determine niche breadth have remained unclear. Here, bacterial niche breadth based on a large-scale soil survey across a wide range of environmental gradients at a national-scale is characterized, and evaluated their life-history traits utilizing over 2000 bacterial genomic datasets from the Genome Taxonomy Database (GTDB). A positive relationship between gene functional diversity and niche breadth is found, and identified a key set of bacterial traits associated with niche breadth, which are assigned to five life-history categories, encompassing growth, competition, stress tolerance, resource acquisition, and dispersal ability. The traits of these categories are captured by distinct clusters in the full dimensionality of trait space, suggesting that a broad-niche taxon may indeed possess multiple facets of life history strategies essential for survival in diverse environments. Bacterial taxa with wider niche breadth maximized a diversity of traits associated with different life history strategies, whereas specialists tended to harbor a smaller number of traits associated with fewer life history strategies. Together, this study offers new insights into developing a trait-based understanding of bacterial niche breadth from the perspective of life history theory.}, archive = {J_ADVS}, author = {Ziheng Peng and Yiran Zhang and Xiaomeng Li and Hang Gao and Yu Liu and Yining An and Xun Qian and Gehong Wei and Shuo Jiao}, doi = {10.1002/advs.202405947}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2405947}, shortjournal = {Adv. Sci.}, title = {Trait-based life history strategies shape bacterial niche breadth}, volume = {12}, year = {2025}, }
• (2025). Deciphering the transcription factor landscape in prostate cancer progression: A novel approach to understand NE transdifferentiation. ADVS, 12(20), 2404938. (www)

  @article{ , abstract = {Prostate cancer (PCa) stands as a leading cause of cancer-related mortality among men, with treatment-induced neuroendocrine prostate cancer (NEPC) posing a challenge as an ARPI-resistant subtype. The role of transcription factors (TFs) in PCa progression and NEPC transdifferentiation remains inadequately understood, underscoring a critical gap in current research. In this study, an internal Z score-based approach is developed to identify lineage-specific TF profiles in prostatic adenocarcinoma and NEPC for a nuanced understanding of TF expression dynamics. Distinct TF profiles for adenocarcinoma and NEPC are unveiled, identifying 126 shared TFs, 46 adenocarcinoma-TFs, and 56 NEPC-TFs, validated across multiple cohorts. Gene Ontology is employed to validate their biological and functional roles in PCa progression. Implications are revealed in cell development, differentiation, and lineage determination. Knockdown experiments suggest that lineage-TFs are functionally important in maintaining lineage-specific cell proliferation. Additionally, a longitudinal study on NE transdifferentiation highlights dynamic TF expression shifts, proposing a three-phases hypothesis for PCa progression mechanisms. This study introduces a groundbreaking approach for deciphering the TF landscape in PCa, providing a molecular basis for adenocarcinoma to NEPC progression, and paving the way for innovative treatment strategies with potential impact on patient outcomes.}, archive = {J_ADVS}, author = {Yu Wang and Hui Xue and Xiaohui Zhu and Dong Lin and Zheng Chen and Xin Dong and Junru Chen and Mingchen Shi and Yuchao Ni and Jonathan Cao and Rebecca Wu and Connie Kang and Xinyao Pang and Francesco Crea and Yen-Yi Lin and Colin C. Collins and Martin E. Gleave and Abhijit Parolia and Arul Chinnaiyan and Christopher J. Ong and Yuzhuo Wang}, doi = {10.1002/advs.202404938}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2404938}, shortjournal = {Adv. Sci.}, title = {Deciphering the transcription factor landscape in prostate cancer progression: A novel approach to understand NE transdifferentiation}, volume = {12}, year = {2025}, }
• (2025). Disentangling the switching behavior in functional connectivity dynamics in autism spectrum disorder: Insights from developmental cohort analysis and molecular-cellular associations. ADVS, 12(20), 2403801. (www)

  @article{ , abstract = {Characterizing the transition or switching behavior between multistable brain states in functional connectivity dynamics (FCD) holds promise for uncovering the underlying neuropathology of Autism Spectrum Disorder (ASD). However, whether and how switching behaviors in FCD change in patients with developmental ASD, as well as their cellular and molecular basis, remains unexplored. This study develops a region-wise FCD switching index (RFSI) to investigate the drivers of FCD. This work finds that brain regions within the salience, default mode, and frontoparietal networks serve as abnormal drivers of FCD in ASD across different developmental stages. Additionally, changes in RFSI at different developmental stages of ASD correlated with transcriptomic profiles and neurotransmitter density maps. Importantly, the abnormal RFSI identifies in humans has also been observed in genetically edited ASD monkeys. Finally, single-nucleus RNA sequencing data from patients with developmental ASD are analyzed and aberrant switching behaviors in FCD may be mediated by somatostatin-expressing interneurons and altered differentiation patterns in astrocyte State2. In conclusion, this study provides the first evidence of abnormal drivers of FCD across different stages of ASD and their associated cellular and molecular mechanisms. These findings deepen the understanding of ASD neuropathology and offer valuable insights into treatment strategies.}, archive = {J_ADVS}, author = {Wei Li and Xia Qiu and Jin Chen and Kexuan Chen and Meiling Chen and Yinyan Wang and Wenjie Sun and Jing Su and Yongchang Chen and Xiaobao Liu and Congying Chu and Jiaojian Wang}, doi = {10.1002/advs.202403801}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2403801}, shortjournal = {Adv. Sci.}, title = {Disentangling the switching behavior in functional connectivity dynamics in autism spectrum disorder: Insights from developmental cohort analysis and molecular-cellular associations}, volume = {12}, year = {2025}, }
• (2025). Performance of liquid biopsy-based multi-omics biomarkers for early detection of gynecological malignancies: A prospective study (PERCEIVE-i). ADVS, 12(20), 2401760. (www)

  @article{ , abstract = {Liquid biopsy is a promising approach for early detection of gynecological malignancies. In the PERCEIVE-I study, gynecological Cancer cases ( n = 249) and age-matched non-cancer controls ( n = 249) are randomly divided into training and test sets at a 1:1 ratio. Data derived from multi-omics assays are obtained including a cell-free DNA methylation panel targeting ≈490 000 CpG sites, a mutation panel comprising 168 genes, and eight tumor protein markers. The results showed that the methylation model outperformed the protein and mutation models, demonstrating higher sensitivity (77.2%) while maintaining similar specificity. The multi-omics model combining methylation and protein markers achieved improved sensitivity (81.9%) with a good specificity (96.9%). The sensitivity varied across different stages, ranging from 66.7% to 100%. The model accurately identified the tissue of origin in 72.1% of cases. The superior performance of the methylation model highlights the potential of integrating multi-omics for non-invasive early detection of gynecological malignancies.}, archive = {J_ADVS}, author = {Zheng Feng and Huijuan Ge and Jingshu Wang and Yanan Wang and Xiaoran Sun and Bo Yang and Siyu Cao and Chenlian Quan and Qinhao Guo and Yusheng Han and Feidie Duan and Fang liu and Jing Zhao and Guoqiang Wang and Yuzi Zhang and Shangli Cai and Xiaohua Wu and Hao Wen}, doi = {10.1002/advs.202401760}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2401760}, shortjournal = {Adv. Sci.}, title = {Performance of liquid biopsy-based multi-omics biomarkers for early detection of gynecological malignancies: A prospective study (PERCEIVE-i)}, volume = {12}, year = {2025}, }
• (2025). Asymmetric inter-hemisphere communication contributes to speech acquisition of toddlers with cochlear implants. ADVS, 12(20), 2309194. (www)

  @article{ , abstract = {How the lateralized language network and its functions emerge with early auditory experiences remains largely unknown. Here, early auditory development is examined using repeated optical imaging for cochlear implanted (CI) toddlers with congenital deafness from onset of restored hearing to around one year of CI hearing experiences. Machine learning models are constructed to resolve how functional organization of the bilateral language network and its sound processing support the CI children's post-implantation development of auditory and verbal communication skills. Behavioral improvement is predictable by cortical processing as well as by network organization changes, with the highest classification accuracy of 81.57%. For cortical processing, behavioral prediction is better for the left than the right hemisphere and for speech than non-speech processing. For network organization, the best prediction is obtained for resting state, with greater contribution from inter-hemisphere connections between non-homologous regions than from within-hemisphere connections. Most interestingly, systematic connectivity-to-activity models reveal that speech processing of the left language network is developmentally supported largely by global network organization, particularly asymmetric inter-hemisphere communication, rather than functional segregation of local network. These findings collectively confirm the importance of asymmetric inter-hemisphere communication in formation of the lateralized language network and its functional development with early auditory experiences.}, archive = {J_ADVS}, author = {Xue Zhao and Meiyun Wu and Haotian Liu and Yuyang Wang and Zhikai Zhang and Yuhe Liu and Yu-Xuan Zhang}, doi = {10.1002/advs.202309194}, journal = {Advanced Science}, month = {5}, number = {20}, pages = {2309194}, shortjournal = {Adv. Sci.}, title = {Asymmetric inter-hemisphere communication contributes to speech acquisition of toddlers with cochlear implants}, volume = {12}, year = {2025}, }
• (2025). Deciphering auditory hyperexcitability in otogl mutant mice unravels an auditory neuropathy mechanism (Adv. sci. 19/2025). ADVS, 12(19), 2570147. (www)

  @article{ , archive = {J_ADVS}, author = {Mathilde Gagliardini and Sabrina Mechaussier and Carolina Campos Pina and Monica Morais and Olivier Postal and Philippe Jean and Typhaine Dupont and Amrit Singh-Estivalet and Shéhanie Udugampolage and Cyril Scandola and Elisabeth Verpy and Baptiste Libé-Philippot and Talya C. Inbar and Joanna Schwenkgrub and Carla Maria Barbosa Spinola and Raphaël Etournay and Aziz El-Amraoui and Brice Bathellier and Adeline Mallet and Sedigheh Delmaghani and Fabrice Giraudet and Christine Petit and Boris Gourévitch and Paul Avan and Nicolas Michalski}, doi = {10.1002/advs.202570147}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2570147}, shortjournal = {Adv. Sci.}, title = {Deciphering auditory hyperexcitability in otogl mutant mice unravels an auditory neuropathy mechanism (Adv. sci. 19/2025)}, volume = {12}, year = {2025}, }
• (2025). ALKBH3-mediated M1A demethylation of METTL3 endows pathological Fibrosis:Interplay between M1A and M6A RNA methylation (Adv. sci. 19/2025). ADVS, 12(19), 2570146. (www)

  @article{ , archive = {J_ADVS}, author = {Liying Tu and Shuchen Gu and Ruoqing Xu and En Yang and Xin Huang and Hsin Liang and Shenying Luo and Haizhou Li and Yixuan Zhao and Tao Zan}, doi = {10.1002/advs.202570146}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2570146}, shortjournal = {Adv. Sci.}, title = {ALKBH3-mediated M1A demethylation of METTL3 endows pathological Fibrosis:Interplay between M1A and M6A RNA methylation (Adv. sci. 19/2025)}, volume = {12}, year = {2025}, }
• (2025). Laser ultrafast confined alloying of sub-5 nm RuM (M = cu, rh, and pd) particles on carbon nanotubes for hydrogen evolution reaction (Adv. sci. 19/2025). ADVS, 12(19), 2570145. (www)

  @article{ , archive = {J_ADVS}, author = {Taiping Hu and Dongshi Zhang and Ningning He and Shuxian Wei and Xingyu Kang and Wei Zhang and Yunyu Cai and Yixing Ye and Pengfei Li and Changhao Liang}, doi = {10.1002/advs.202570145}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2570145}, shortjournal = {Adv. Sci.}, title = {Laser ultrafast confined alloying of sub-5 nm RuM (M = cu, rh, and pd) particles on carbon nanotubes for hydrogen evolution reaction (Adv. sci. 19/2025)}, volume = {12}, year = {2025}, }
• (2025). DNA origami-cyanine nanocomplex for precision imaging of KRAS-mutant pancreatic cancer cells (Adv. sci. 19/2025). ADVS, 12(19), 2570144. (www)

  @article{ , archive = {J_ADVS}, author = {Hye-ran Moon and Yancheng Du and Sae Rome Choi and Seongmin Seo and Cih Cheng and Bennett D. Elzey and Jong Hyun Choi and Bumsoo Han}, doi = {10.1002/advs.202570144}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2570144}, shortjournal = {Adv. Sci.}, title = {DNA origami-cyanine nanocomplex for precision imaging of KRAS-mutant pancreatic cancer cells (Adv. sci. 19/2025)}, volume = {12}, year = {2025}, }
• (2025). Elastic relaxation of coherent InGaN/GaN interfaces at the microwire LED sidewall (Adv. sci. 19/2025). ADVS, 12(19), 2570142. (www)

  @article{ , archive = {J_ADVS}, author = {Jongil Kim and Jinwook Yeo and Bumsu Park and Jeehun Jeong and Seunghwa Ryu and Sang Ho Oh}, doi = {10.1002/advs.202570142}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2570142}, shortjournal = {Adv. Sci.}, title = {Elastic relaxation of coherent InGaN/GaN interfaces at the microwire LED sidewall (Adv. sci. 19/2025)}, volume = {12}, year = {2025}, }
• (2025). Cyclo-n9−: A novel 5/6 fused polynitrogen anion for high energy density materials (Adv. sci. 19/2025). ADVS, 12(19), 2570141. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaofeng Yuan and Ze Xu and Haolin Gu and Tongwei Zhang and Yuangang Xu and Ming Lu}, doi = {10.1002/advs.202570141}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2570141}, shortjournal = {Adv. Sci.}, title = {Cyclo-n9−: A novel 5/6 fused polynitrogen anion for high energy density materials (Adv. sci. 19/2025)}, volume = {12}, year = {2025}, }
• (2025). Artificial cornea substitute based on hydrogel skeletons with natural stromal hierarchical structure and extracellular matrix for sutureless transplantation (Adv. sci. 19/2025). ADVS, 12(19), 2570140. (www)

  @article{ , archive = {J_ADVS}, author = {Long Zhao and Zhen Shi and Xiaoyu Zhang and Jingting Wang and Shang Yang and Fuyan Wang and Tan Li and Qingjun Zhou and Ting Wang and Weiyun Shi}, doi = {10.1002/advs.202570140}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2570140}, shortjournal = {Adv. Sci.}, title = {Artificial cornea substitute based on hydrogel skeletons with natural stromal hierarchical structure and extracellular matrix for sutureless transplantation (Adv. sci. 19/2025)}, volume = {12}, year = {2025}, }
• (2025). Outermost cationic surface charge of layer-by-layer films prevents endothelial cells migration for cell compartmentalization in three-dimensional tissues (Adv. sci. 19/2025). ADVS, 12(19), 2570139. (www)

  @article{ , archive = {J_ADVS}, author = {Jinfeng Zeng and Sven Heilig and Matthias Ryma and Jürgen Groll and Congju Li and Michiya Matsusaki}, doi = {10.1002/advs.202570139}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2570139}, shortjournal = {Adv. Sci.}, title = {Outermost cationic surface charge of layer-by-layer films prevents endothelial cells migration for cell compartmentalization in three-dimensional tissues (Adv. sci. 19/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “A senomorphlytic three-drug combination discovered in salsola collina for delaying aging phenotypes and extending healthspan”. ADVS, 12(19), 2505321. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202505321}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2505321}, shortjournal = {Adv. Sci.}, title = {Correction to “A senomorphlytic three-drug combination discovered in salsola collina for delaying aging phenotypes and extending healthspan”}, volume = {12}, year = {2025}, }
• (2025). Unveiling the over-lithiation behavior of NCM523 cathode towards long-life anode-free li metal batteries. ADVS, 12(19), 2503558. (www)

  @article{ , abstract = {Anode-free lithium metal batteries (AFLMBs) offer the potential for significantly enhanced energy densities. However, their practical application is limited by a shortened cycling life due to inevitable Li loss from parasitic reactions. This study addresses this challenge by incorporating an over-lithiated Li 1+ x Ni 0.5 Co 0.2 Mn 0.3 O 2 (Li 1+ x NCM523) cathode as an internal Li reservoir to compensate for lithium loss during extended cycling. A rigorous investigation of the deep discharge behavior of the Li 1+ x NCM523 cathode reveals a critical over-lithiation threshold at x = 0.7. At this threshold, excess Li + ions are safely accommodated within the crystal structure by a transformation from the LiO 4 octahedron to two tetrahedral sites. Beyond this threshold ( x ≥ 0.7), the structural stability of the cathode is significantly compromised due to the irreversible reduction of transition metal (TM) ions. The optimal Li-rich Li 1.7 NCM523 releases an additional charge capacity of ≈160 mAh g −1 during the first charge. Consequently, the AFLMBs (Li 1.7 NCM523||Cu) achieve outstanding capacity retention of 93.3% after 100 cycles at 0.5 C and 78.5% after 200 cycles at 1 C. The findings establish a research paradigm for designing superior over-lithiated transition metal oxide cathode materials and underscore the critical role of the lithium reservoir in extending the cycle life of AFLMBs.}, archive = {J_ADVS}, author = {Ruimin Gao and Minzhi Zhan and Tingcan Li and Pei Xiong and Qian Zhang and Zhefeng Chen and Jike Wang and Xinping Ai and Feng Pan and Liumin Suo and Jiangfeng Qian}, doi = {10.1002/advs.202503558}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2503558}, shortjournal = {Adv. Sci.}, title = {Unveiling the over-lithiation behavior of NCM523 cathode towards long-life anode-free li metal batteries}, volume = {12}, year = {2025}, }
• (2025). 3D self-supported visible light photochemical nanocatalysts. ADVS, 12(19), 2502981. (www)

  @article{ , abstract = {This work focuses on 3D, self-supported, nanofibrous TiO 2 structures (nanogrids) prepared using blend electrospinning. The presence of anatase and brookite phases in Cu-doped TiO 2 nanogrids significantly enhances the photocatalytic properties of the titania system. The absorption edge in Cu-doped TiO 2 shifts to the visible due to the narrowed bandgap and efficient separation of photogenerated charge carriers facilitated by Cu doping. The presence of the brookite phase further contributes to the enhanced performance, by reducing electron–hole recombination. A wide range of characterization techniques, including cyclic voltammetry and chronoamperometry studies which show that the Cu doped TiO₂ sample generates a significant photocurrent under visible light, are employed to elucidate the role of Cu doping in enhancing the visible light photocatalytic efficiency of TiO 2 nanogrids, offering valuable insights for developing advanced photochemical catalysts for environmental and energy applications. The nanogrids studied here are far superior to P25 Degussa and are activated by natural sunlight and do not require a filtration system to remove nanoparticles from the water. These self-supported nanofibrous photochemical catalysts offer all the benefits of nanomaterials while suffering from none of their drawbacks.}, archive = {J_ADVS}, author = {Fateh Mikaeili and Mohammad Mahafuzur Rahaman and Pelagia-Irene (Perena) Gouma}, doi = {10.1002/advs.202502981}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2502981}, shortjournal = {Adv. Sci.}, title = {3D self-supported visible light photochemical nanocatalysts}, volume = {12}, year = {2025}, }
• (2025). The charge storage mechanism and durable operation in Olivine–Lithium–Iron–Phosphate for mn-based hybrid batteries. ADVS, 12(19), 2502866. (www)

  @article{ , abstract = {Aqueous batteries have garnered considerable attention because of their cost-effectiveness, sufficient capacity, and non-flammable water-based electrolytes. Among these, manganese batteries are particularly attractive owing to their stability, abundance, affordability, and higher energy density. With a lower redox potential (Mn: −1.19 V vs SHE) than zinc (Zn: −0.76 V vs SHE), manganese batteries theoretically offer superior energy density over traditional zinc-based systems. In this study, LiFePO 4 is introduced as a cathode material in aqueous manganese-based hybrid batteries for the first time. Through electrochemical characterization and advanced structural and spectroscopic analyses, the charge storage mechanisms of protons in to the FePO 4 are elucidated. Cation diffusion pathways are also investigated via diffusion barrier calculations. This study presents manganese hybrid batteries with a good stability and capacity of ≈109.2 mAh g −1 at 40 mA g −1 , alongside a cycle retention of 42.1% after 3000 cycles at 320 mA g −1 . Furthermore, an Mn 2+ /Li + hybrid battery, achieving ≈1.6 V and superior durability (81.5% @ 1000th), is proposed.}, archive = {J_ADVS}, author = {Jangwook Pyun and Hyungjin Lee and Hyeonjun Lee and Sangki Lee and Seunghyeop Baek and Hyeju Kwon and Seung-Tae Hong and Munseok S. Chae}, doi = {10.1002/advs.202502866}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2502866}, shortjournal = {Adv. Sci.}, title = {The charge storage mechanism and durable operation in Olivine–Lithium–Iron–Phosphate for mn-based hybrid batteries}, volume = {12}, year = {2025}, }
• (2025). Generation of a high-precision whole liver panorama and cross-scale 3D pathological analysis for hepatic fibrosis. ADVS, 12(19), 2502744. (www)

  @article{ , abstract = {The liver harbors complex cross-scale structures, and the fibrosis-related alterations to these structures have a severe impact on the diverse function of the liver. However, the hepatic anatomic structures and their pathological alterations in the whole-liver scale remain to be elucidated. Combining the micro-optical sectioning tomography (MOST) system and liver Nissl staining, a first high-precision whole mouse liver atlas is generated, enabling visualization and analysis of the entire mouse liver. Thus, a detailed 3D panorama of CCl4-induced liver fibrosis pathology is constructed, capturing the 3D details of the central veins, portal veins, arteries, bile ducts, hepatic sinusoids, and liver cells. Pathological changes, including damaged sinusoids, steatotic hepatocytes, and collagen deposition, are region-specific and concentrated in the pericentral areas. The quantitative analysis shows a significantly reduced diameter and increased length density of the central vein. Additionally, a deep learning tool is used to segment steatotic hepatocytes, finding that the volume proportion of steatotic regions is similar across liver lobes. Steatosis severity increases with proximity to the central vein, independent of central vein diameter. The approach allows the cross-scale visualization of multiple structural components in liver research and promotes pathological studies from a 2D to a 3D perspective.}, archive = {J_ADVS}, author = {Xiaochuan Zhang and Weicheng Yang and Xiaoliang Li and Yanli Zhao and Zongneng Xie and Shuangqu Li and Yue Zeng and Xiaoxu Hao and Xiaohong Xin and Yu Zhang and Zixuan Feng and Hualiang Jiang and Zhaobing Gao and Xianzhen Yin}, doi = {10.1002/advs.202502744}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2502744}, shortjournal = {Adv. Sci.}, title = {Generation of a high-precision whole liver panorama and cross-scale 3D pathological analysis for hepatic fibrosis}, volume = {12}, year = {2025}, }
• (2025). Realizing high performance in flexible Mg3Sb2−xBix thin-film thermoelectrics. ADVS, 12(19), 2502683. (www)

  @article{ , abstract = {As advancements in Mg-based thermoelectric materials continue, increasing attention is directed toward enhancing the thermoelectric performance of Mg 3 Sb 2 and its integration into thermoelectric devices. However, research on Mg 3 Sb 2 thin films and their application in flexible devices remains limited, leaving ample room for improvements in fabrication techniques and thermoelectric properties. To address these gaps, this study employs magnetron sputtering combined with ex-situ annealing to dope Bi into Mg 3 Sb 2 thin films, partially substituting Sb. This approach enhances the near-room-temperature performance and plasticity, yielding high-performance Mg 3 Sb 2− x Bi x thermoelectric thin films. The films achieve a power factor of 3.77 µW cm −1 K −2 at 500 K, the highest value reported for p-type Mg 3 Sb 2 thin films to date. Comprehensive characterization demonstrates precise thickness control, strong adhesion to various substrates, and excellent flexibility, with performance degradation of less than 12% after 1000 bending cycles at a radius of 5 mm. Additionally, a flexible thermoelectric device is constructed using p-type Mg 3 Sb 1.1 Bi 0.9 and n-type Ag 2 Se legs, achieving an output power of 9.96 nW and a power density of 77.38 µW cm −2 under a temperature difference of 10 K. These findings underscore the potential of these devices for practical applications in wearable electronics.}, archive = {J_ADVS}, author = {Boxuan Hu and Xiao-Lei Shi and Tianyi Cao and Min Zhang and Wenyi Chen and Siqi Liu and Meng Li and Weidi Liu and Zhi-Gang Chen}, doi = {10.1002/advs.202502683}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2502683}, shortjournal = {Adv. Sci.}, title = {Realizing high performance in flexible Mg3Sb2−xBix thin-film thermoelectrics}, volume = {12}, year = {2025}, }
• (2025). The dynamic landscape of 3′-UTR alternative polyadenylation across mouse fetal development and anatomy. ADVS, 12(19), 2502443. (www)

  @article{ , abstract = {Alternative cleavage and polyadenylation (APA) in the 3′-untranslated region (3′-UTR) of mRNA produces transcripts with varied 3′-UTR and plays a key role in development and organogenesis. This work characterizes 3′-UTR APA using 85 high-quality RNA-seq datasets encompassing 12 tissue types and eight developmental stages of mouse fetuses. Results show that 46.4% of expressed genes undergo APA in a tissue-specific manner. Changes in polyadenylation site (pAS) usage often operate beyond transcriptional control, revealing APA as an additional layer of gene regulation. Sequence analysis demonstrates that pAS selection, governed by polyadenylation signal strength and adenine preferences, is evolutionarily conserved between mice and humans. Intriguingly, brain tissues display complex 3′-UTR APA dynamics during development, potentially regulated by RNA-binding proteins such as Rbm38 , potentially impacting 3′ UTR extension by restricting distal pAS usage. These APA events are associated with a depletion of conserved miRNA binding sites and an enrichment of transposable elements within alternative 3′ UTRs. To facilitate further research, this work develops APApedia ( http://xozhanglab.com/apapedia/ ), a comprehensive database cataloging identified 3′-UTR APA events, which serves as a valuable resource for the community to study APA in development and tissue-specific regulation. This comprehensive resource aids in deciphering the functional implications of APA in mouse fetal development.}, archive = {J_ADVS}, author = {Qin Wang and Xin Chen and Xiao-Ou Zhang}, doi = {10.1002/advs.202502443}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2502443}, shortjournal = {Adv. Sci.}, title = {The dynamic landscape of 3′-UTR alternative polyadenylation across mouse fetal development and anatomy}, volume = {12}, year = {2025}, }
• (2025). A universal and versatile zwitterionic coating for blood-contacting catheters with long lengths and complex geometries. ADVS, 12(19), 2502411. (www)

  @article{ , abstract = {Blood-contacting catheters are highly susceptible to thrombus formation, making heparin coating essential for reducing clinical complications. However, the limitations of heparin coatings have spurred significant efforts to develop alternative strategies. This study demonstrates a cost-efficient, mechanically viable, and universal zwitterion coating approach for long and complex catheters with near-zero fouling, super anticoagulation, and selective biocapturing. Leveraging the synergistic action of side groups, a wet-adhesive initiator-bearing polymer rapidly assembles on catheter surfaces in aqueous environments, facilitating the grafting of superhydrophilic and zwitterionic polymers onto catheter inner walls. This strategy demonstrates broad adaptability, successfully applying to ten substrates and showing exceptional versatility in modifying catheters and joints of various shapes and sizes. These coatings exhibit near-zero protein fouling across a broad pH range, and superior resistance to blood cells and bacteria. Furthermore, they maintain excellent stability under simulated bloodstream without compromising anticoagulant performance. Beyond antifouling properties, this method enables the construction of highly selective bio-interaction networks on catheter inner walls, allowing precise capture of circulating tumor cells from blood. This zwitterion coating technique, with its rapid modification, robust anticoagulant properties, and customizable bio-functionality, provides an attractive solution for, beyond catheters, a wide range of medical devices that must perform in challenging biological environments.}, archive = {J_ADVS}, author = {Tong Zhang and Tian Liang and Qichao Pan and Shouyan Zhang and Shuhua Zhang and Zhi Geng and Bo Zhu}, doi = {10.1002/advs.202502411}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2502411}, shortjournal = {Adv. Sci.}, title = {A universal and versatile zwitterionic coating for blood-contacting catheters with long lengths and complex geometries}, volume = {12}, year = {2025}, }
• (2025). Polarization-controlled transmissive plasmonic color filter using a dimer-aperture array. ADVS, 12(19), 2501941. (www)

  @article{ , abstract = {Complex color and polarization selective technologies are of increasing importance in scientific, security, and commercial imaging applications. A new dimeric plasmonic filter structure based on periodic aperture arrays is reported to provide an effective method for making planar color-selective structures by exploiting the properties of extraordinary optical transmission in thin metal films. The visible band transmission-mode polarization-dependent color filters reported in this work exploit only a single layer of aluminum patterned using a hexagonally periodic dimer-ellipse aperture structure. It is shown experimentally that the structure exhibits a minimum extinction ratio of over 20, 100, and 150 for red, green, and blue channels respectively, and a peak transmission of over 30%. It is demonstrated that dual images can be encoded using polarization selectivity into a single structure. The fidelity of the method is demonstrated with micro-scale reproductions of complex artworks showing the ability to reproduce 76% of the sRGB color gamut with polarization selectivity. The structure can be readily fabricated with only a single-step lithography and etching process, so that the technique may be widely used.}, archive = {J_ADVS}, author = {Shuhao Wu and Peter W.R. Connolly and Vincenzo Pusino and Gerald S. Buller and David R.S. Cumming}, doi = {10.1002/advs.202501941}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501941}, shortjournal = {Adv. Sci.}, title = {Polarization-controlled transmissive plasmonic color filter using a dimer-aperture array}, volume = {12}, year = {2025}, }
• (2025). Enhanced broadband acoustic absorption in commercial foam via multiwall carbon nanotube-induced pore reconstruction. ADVS, 12(19), 2501898. (www)

  @article{ , abstract = {Noise pollution is an urgent environmental issue that leads to a series of adverse effects on human physical and mental health. Porous materials with rationally designed micropores or channels can effectively absorb noise across wide frequency ranges, making them a well-established candidate for mitigating acoustic propagation. However, common porous materials with a singular pore structure face a trade-off between acoustic absorption efficiency and thickness. Herein, this challenge is significantly mitigated by reconstructing the pore structure of commercial melamine foam using multiwall carbon nanotubes (MWCNTs). The melamine/MWCNTs foam exhibits multiscale composite pores, high porosity, and increased specific surface area while preserving the shape and thickness of the initial melamine foam. Due to increased energy dissipation from the porous structure and the resonance effect of MWCNTs, the 10 mm thick composite porous absorber exhibits an average absorption coefficient of ≈70% from 1300 to 6000 Hz, representing a 196.5% increase compared with that of initial melamine foam. The reconstructing pore structure by loading MWCNTs is a simple and general method for improving the acoustic absorption coefficient. It can be extended to other complex morphologies or material systems, offering significant application potential in noise control, acoustic instruments, and architectural design.}, archive = {J_ADVS}, author = {Jinkui Xiong and Jinlong Liu and Wengui Lin and Yifei Li and Longchao Liao and Mingfu Wen and Guisheng Zhong and Xiaodong Niu and Longshi Rao and Quan Wang and Bin Bao and Qingxian Liu}, doi = {10.1002/advs.202501898}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501898}, shortjournal = {Adv. Sci.}, title = {Enhanced broadband acoustic absorption in commercial foam via multiwall carbon nanotube-induced pore reconstruction}, volume = {12}, year = {2025}, }
• (2025). Highly absorbent ultrafast self-gelling starch microparticles for robust wet-tissue adhesion and instant hemostasis. ADVS, 12(19), 2501857. (www)

  @article{ , abstract = {Rapid and effective hemostasis of mass bleeding from irregularly shaped wounds remains a critical clinical challenge. Herein, a highly absorbent and self-gelling microparticle (MP) is reported based on modified starch as a hemostatic material with robust wet tissue adhesiveness. The aldehyde- and catechol-modified starch (ACS) is synthesized via partial oxidation of starch for the reduction of dense intermolecular interactions within starch, thereby significantly enhancing its interaction with water molecules. Moreover, the conjugated catechol group strengthens the affinity to various biomolecules. The ACS microparticle (ACS-MP) prepared by calcium intercalation into the polysaccharide chains and subsequent freeze-milling rapidly converts to a stable hydrogel within seconds upon hydration, exhibiting superior water absorption capacity and tissue adhesion. The ACS-MP demonstrates excellent in vivo biocompatibility in local and systemic administration. The application of ACS-MP to bleeding wounds enables rapid blood absorption and accumulation of blood components and coagulation factors. The ACS-MP can fill irregularly shaped wounds, forming a tissue-adhesive hydrogel in situ, thereby creating a physical barrier for non-compressible hemostasis. The superior hemostatic performance of ACS-MP against massive hemorrhage from liver injuries in mice and pigs is confirmed. The ACS-MP will be a promising hemostat for effectively controlling mass bleeding in various tissues in clinical settings.}, archive = {J_ADVS}, author = {Soohwan An and Jihoon Jeon and Seung Yeop Han and Mi Jeong Lee and Tae-Gyeong Oh and Eun Je Jeon and Dong Jin Joo and Seung-Woo Cho}, doi = {10.1002/advs.202501857}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501857}, shortjournal = {Adv. Sci.}, title = {Highly absorbent ultrafast self-gelling starch microparticles for robust wet-tissue adhesion and instant hemostasis}, volume = {12}, year = {2025}, }
• (2025). Rational design and organoid-based evaluation of a cocktail CAR-γδ t cell therapy for heterogeneous glioblastoma. ADVS, 12(19), 2501772. (www)

  @article{ , abstract = {Various challenges, including tumor heterogeneity and inadequate T cell infiltration, impede the progress of chimeric antigen receptor T cell (CAR-T) therapy for glioblastoma (GBM). To address these obstacles, a multiple step strategy is designed. Initially, literature review and bioinformatics analysis to screen a set of antigens that are heterogeneously expressed in GBM, which are designated as the target-bank, are leveraged. Then, according to the multiplex immunohistochemistry results of each patient's tumor sample, a personalized panel of antigens based on the principle that most cancer cells in tumor tissues can be covered from the target-bank is selected. To target these antigens, Vδ1 T cells are chosen as CAR vehicles because of its high tissue infiltration and off-the-shelf properties, and an optimized protocol for engineering CAR-Vδ1 T cells with high purity and cytotoxicity, low exhaustion, and cytokine release is developed. Next, the specific panel of cocktail CAR-Vδ1 T cells in the GBM organoids that are directly derived from the same patient's tumor is tested. The term “ prof ” cocktail therapy is coined to describe the approach using precise and rational combination of tumor antigens, organoid-based evaluation, and fitness of Vδ1 T cells. It may accelerate development of effective CAR-T drugs for heterogeneous solid tumors.}, archive = {J_ADVS}, author = {Guidong Zhu and Zhongzheng Sun and Yingchao Liu and Jiang Liu and Linpei Guo and Guojing Pei and Ying Jiang and Baowang Miao and Zhen Li and Ping Zhang and Dongqi Tang and Wen Zhang and Chengwei Wang}, doi = {10.1002/advs.202501772}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501772}, shortjournal = {Adv. Sci.}, title = {Rational design and organoid-based evaluation of a cocktail CAR-γδ t cell therapy for heterogeneous glioblastoma}, volume = {12}, year = {2025}, }
• (2025). Rotation-based snap-fit mechanical metamaterials. ADVS, 12(19), 2501749. (www)

  @article{ , abstract = {Multistable mechanical metamaterials have broad application prospects in various fields due to their unique configuration transformation ability, such as energy absorption, shape reconstruction, soft actuator design, mechanical storage, and logic operation. Currently, the steady-state transition mechanisms for most multistable mechanical metamaterials rely on translational displacement input, while the rotational input mechanisms are rarely studied. Here, a curved beam snap-fit structure is proposed to realize the multistable transition of metamaterials under rotational load. Their mechanical characteristics and influencing factors are discussed in detail through theoretical analysis, numerical simulation, and experimental verification. In addition, related rotational multistable mechanical metamaterials prototypes are designed. Their potential applications in the fields of energy absorption or robotics are demonstrated, which opens up new ideas and directions for the multifunctional applications of mechanical metamaterials.}, archive = {J_ADVS}, author = {Rui Xu and Yulong He and Chuanqing Chen and Jiapeng Sun and Xin Li and Ming-Hui Lu and Yan-Feng Chen}, doi = {10.1002/advs.202501749}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501749}, shortjournal = {Adv. Sci.}, title = {Rotation-based snap-fit mechanical metamaterials}, volume = {12}, year = {2025}, }
• (2025). Methionine metabolism dictates PCSK9 expression and antitumor potency of PD-1 blockade in MSS colorectal cancer. ADVS, 12(19), 2501623. (www)

  @article{ , abstract = {Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored. Here it is demonstrated that methionine restriction inhibits the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of cholesterol homeostasis and a potential target for cancer immunotherapy, in colorectal cancer (CRC) but not in the liver. Mechanistically, methionine is catabolized to S-adenosylmethionine (SAM), promoting mRNA transcription of PCSK9 through increased DNA methyltransferase 1 (DNMT1)-mediated DNA methylation and suppression of sirtuin 6 (SIRT6) expression. Furthermore, both PCSK9 inhibition and dietary methionine restriction (DMR) potentiate PD-1 blockade therapy and foster the infiltration of CD8 + T cells in Colon 26 tumor-bearing mice—a proficient mismatch repair (pMMR)/microsatellite stable (MSS) CRC model that exhibits limited response to anti-PD-1 therapy. Moreover, combining 5-fluorouracil (5-FU) chemotherapy with PCSK9 inhibition and PD-1 blockade further augments therapeutic efficacy for MSS CRC. The findings establish a mechanistic link between amino acid metabolism and cholesterol metabolism within the tumor microenvironment where tumor cells sense methionine to regulate PCSK9 expression, highlighting promising combination therapeutic strategies that may greatly benefit MSS CRC patients.}, archive = {J_ADVS}, author = {Qi-Long Wang and Zijie Chen and Xiaofei Lu and Huizhen Lin and Huolun Feng and Nuozhou Weng and Liwen Chen and Mengnan Liu and Li Long and Lingjun Huang and Yongmei Deng and Kehong Zheng and Xiaojun Zheng and Yong Li and Ting Cai and Jiabin Zheng and Wei Yang}, doi = {10.1002/advs.202501623}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501623}, shortjournal = {Adv. Sci.}, title = {Methionine metabolism dictates PCSK9 expression and antitumor potency of PD-1 blockade in MSS colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Endogenous near-infrared chemiluminescence: Imaging-guided non-invasive thrombolysis and anti-inflammation based on a heteronuclear transition metal complex. ADVS, 12(19), 2501257. (www)

  @article{ , abstract = {Conventional therapy to treat thrombi (blood clots) has significant limitations: i) inflammation; ii) bleeding side effects; iii) re-embolisation, and iv) in situ thrombi that are not visible. Here it is reported that Cu2Ir nanoparticles (NPs) with a Cu-coordinated tetraphenylporphyrin (TPP) core and cyclometalated Ir(C^N) 2 (N^N) substituents integrate long-lived near-infrared (NIR) chemiluminescence (CL) imaging, photothermal therapy (PTT) and photodynamic therapy (PDT) for thrombolysis, with antioxidant and anti-inflammatory properties. Based on density functional theory calculations the chemiluminescent reaction site between TPP and peroxynitrite (ONOO − ) is confirmed for the first time. The presence of the transition metal significantly improves the chemiluminescent properties of TPP. Upon specific activation by ONOO − , Cu2Ir NPs exhibited more than 30-fold NIR CL intensity than TPP NPs, and the luminescence lasted for 60 min allowing for precise and long-lasting dynamic tracking of thrombi. Cu2Ir NPs achieved non-invasive safe thrombolytic therapy triggered by NIR irradiation at the signaling site. 72.3% blood reperfusion is obtained for nearly complete restoration of blood flow, and re-embolism is prevented in a mouse carotid artery model. Furthermore, Cu2Ir NPs scavenged excess reactive oxygen/nitrogen species (RONS) and reduced inflammatory factors. Cu2Ir NPs hold promise as a single-molecule strategy for diagnosing and treating diseases associated with thrombosis.}, archive = {J_ADVS}, author = {Ziwei Wang and Bo Zhu and Wenxin Nie and Liping Zhang and Nan Xiao and Qiaohua Zhang and Zihan Wu and Chunguang Shi and Weijin Zhu and Qianwen Liu and Dongxia Zhu and Martin R. Bryce and Lijie Ren and Ben Zhong Tang}, doi = {10.1002/advs.202501257}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501257}, shortjournal = {Adv. Sci.}, title = {Endogenous near-infrared chemiluminescence: Imaging-guided non-invasive thrombolysis and anti-inflammation based on a heteronuclear transition metal complex}, volume = {12}, year = {2025}, }
• (2025). Unprecedented ultra-high expansion ratio foam for innovative architecture. ADVS, 12(19), 2501188. (www)

  @article{ , abstract = {Global climate warming has dramatically increased the demand for space cooling. Materials that integrate superior thermal insulation with passive daytime radiative cooling properties hold significant promise for reducing energy consumption for space cooling during hot summers. In this study, conduction-microwave heating assisted CO 2 foaming process is used to optimize cell size and expansion ratios, producing PMMA/PVDF foam with an ultra-high expansion ratio of 120 times and small, uniform cells. The foam is hydrophobic, chemically resistant, and recyclable, with a negative Poisson's ratio structure that gives it outstanding compression strength, elasticity, and flexibility, making it suitable for both everyday use and extreme weather conditions. The inherent properties of the material and its cell structure confer low thermal conductivity (26.69 mW m −1 K −1 ), high solar reflectance (96.37%), and high infrared emissivity (97.34%). This means that indoor cooling of buildings can be achieved in hot weather (15 °C difference in test results before and after use), meeting the cooling needs of buildings in most countries around the world. The ultra-high expansion ratio PMMA/PVDF foam demonstrates significant potential in energy conservation, reducing carbon footprints, and promoting sustainability, providing a solution for the development of next-generation buildings.}, archive = {J_ADVS}, author = {Wenyu Zhong and Yichong Chen and Dongdong Hu and Jiayang Sun and Xingyu Jia and Ling Zhao}, doi = {10.1002/advs.202501188}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501188}, shortjournal = {Adv. Sci.}, title = {Unprecedented ultra-high expansion ratio foam for innovative architecture}, volume = {12}, year = {2025}, }
• (2025). Lattice-distortion-driven reduced lattice thermal conductivity in high-entropy ceramics. ADVS, 12(19), 2501157. (www)

  @article{ , abstract = {Lattice distortion and mass fluctuation are two long-believed potential mechanisms for the reduced lattice thermal conductivity in high-entropy ceramics (HECs). However, related studies remain unclear. Taking high-entropy diborides (HEBs) as the prototype, the lattice-distortion-driven reduced lattice thermal conductivity in HECs is uncovered, whereas the influence of mass fluctuation is neglectable. Specifically, two groups of HEBs are designed by regulating the long-believed mechanisms of lattice distortion and mass fluctuation based on machine-learning-potential-based molecular dynamics simulations. The theoretical and experimental results show that lattice distortion plays a pivotal role in modulating the lattice thermal conductivity of HEBs, while the influence of mass fluctuation is neglectable. Further studies find that the aggravation of lattice distortion enables the reduction of the lattice thermal conductivity through the decreased phonon velocity and Debye temperature resulting from the simultaneously enhanced scattering of strain field fluctuation and bond strength fluctuation. In addition, lattice distortion is found to lower the electronic thermal conductivity by competing with vacancies. The research unravels the long-standing mystery of the reduced lattice thermal conductivity in HECs and offers insightful guidance for developing HECs with ultra-low thermal conductivities.}, archive = {J_ADVS}, author = {Yiwen Liu and Yaming Fu and Fangchao Gu and Hulei Yu and Lei Zhuang and Yanhui Chu}, doi = {10.1002/advs.202501157}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501157}, shortjournal = {Adv. Sci.}, title = {Lattice-distortion-driven reduced lattice thermal conductivity in high-entropy ceramics}, volume = {12}, year = {2025}, }
• (2025). Hypothalamus regulates anabolic metabolism of articular cartilage superficial chondrocytes through PGE2 skeletal interoception. ADVS, 12(19), 2501039. (www)

  @article{ , abstract = {Degeneration of articular cartilage is the key underlying cause of most joint-related diseases and yet little is known about its regeneration. Here, we report that skeletal interoception induces anabolic synthesis of superficial membrane by tuning down sympathetic norepinephrine (NE). Specifically, the superficial membrane is consumed during animal activity and anabolically renewed by the underneath chondrocytes in the superficial zone (SFZ). Notably, by stereotactic knockdown of sympathetic NE synthesis in the paraventricular nucleus, articular cartilage thickness increases. Moreover, deletion of the gene encoding the prostaglandin E2 (PGE2) receptor, EP4, in sensory nerves for ascending interoceptive pathway induces damage of superficial membrane and articular cartilage degeneration. In contrast, increase of interoceptive signaling by elevation of local PGE2 reduces sympathetic outflow to promote the anabolic renewal of superficial membrane. Importantly, inducible knockout of the β-2-adrenergic-receptor (Adrb2) in the SFZ chondrocytes damages superficial membrane and treadmill running aggravates the damage. Mechanistically, NE-mediated activation of Adrb2 induces internalization of Adrb2 and TGF-β type II receptor as a complex, thereby regulating TGF-β activity for articular cartilage homeostasis regeneration. Together, physical activity induces an anabolic renewal of the superficial membrane by downregulation hypothalamic NE for optimized thickness and integrity of articular cartilage.}, archive = {J_ADVS}, author = {Ziyi Wang and Xuequan Han and Jiawen Xu and Weixin Zhang and Kalp Patel and Jinjian Zheng and Mei Wan and Junying Zheng and Xu Cao}, doi = {10.1002/advs.202501039}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501039}, shortjournal = {Adv. Sci.}, title = {Hypothalamus regulates anabolic metabolism of articular cartilage superficial chondrocytes through PGE2 skeletal interoception}, volume = {12}, year = {2025}, }
• (2025). Competitive anion anchoring and hydrogen bonding in multiscale-coupling composite quasi-solid electrolytes for fire-safety and long-life lithium metal batteries. ADVS, 12(19), 2501012. (www)

  @article{ , abstract = {Composite solid-state electrolytes (CSEs) using Li 1+x Al x Ti 2-x (PO 4 ) 3 (LATP) as active fillers offer promising prospects for large-scale lithium metal batteries (LMBs) applications due to their high environmental stability, cost-effectiveness, and improved safety. However, the challenges persist owing to high interfacial resistance with electrodes and instability with lithium metal. Herein, self-assembly nanofiber/polymers/LATP composite quasi-solid electrolytes (SL-CQSEs) are reported through in situ polymerization of precursor solution containing vinylene carbonate (VC), fluoroethylene carbonate (FEC), lithium bis(trifluoromethanesulfonic) imide (LiTFSI) in a porous and flexible self-supporting skeleton (SSK) consisting of 2-(3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido)ethyl methacrylate (UPyMA)’s self-assembly nanofiber (SAF), poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and LATP. Anion-anchoring/hydrogen-bonding competition and intercomponent multiscale-coupling effects on SL-CQSEs are found, which contribute to their incombustibility, excellent room-temperature ionic conductivity (1.03 mS cm −1 ), wide electrochemical window (5.1 V), good interfacial compatibility, and lasting inhibition of lithium dendrites. LiFePO 4 /Li cells with SL-CQSEs not only exhibit high-rate performance and long-term cycling stability, with a capacity retention of 90.4% at 1C and 87% even at 4C after 1000 cycles, but also can resist fire and mechanical abuse, highlighting the potential applications of SL-CQSEs for high-performance and safety LMBs.}, archive = {J_ADVS}, author = {Ding Hu and Guo-Rui Zhu and Ping-Hui Duan and Si-Chong Chen and Gang Wu and Yu-Zhong Wang}, doi = {10.1002/advs.202501012}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2501012}, shortjournal = {Adv. Sci.}, title = {Competitive anion anchoring and hydrogen bonding in multiscale-coupling composite quasi-solid electrolytes for fire-safety and long-life lithium metal batteries}, volume = {12}, year = {2025}, }
• (2025). Symmetrical triboelectric in situ self-powered sensing and fault diagnosis for double-row tapered roller bearings in wind turbines: An integrated and real-time approach. ADVS, 12(19), 2500981. (www)

  @article{ , abstract = {Double-row tapered roller bearings (DTRBs) are widely used in wind turbines because of their high load-bearing capacity and durability. However, wind turbines typically operate in harsh environments, subjecting bearings to complex working conditions, which significantly increases the difficulty of operational status monitoring. Traditional monitoring methods rely on external power sources and complex sensor networks, which make them susceptible to environmental interference, and complicated to maintain. This paper presents an innovative, integrated symmetrical single-electrode triboelectric double-row tapered roller bearing (SST-DTRB) by incorporating a triboelectric nanogenerator (TENG) with DTRB. This scheme converts the frictional energy generated during bearing operation into electrical output, producing signals that enable simultaneous sensing of both ends of DTRB. Experimental results demonstrate that this monitoring scheme exhibits high sensitivity, stability, and reliability, with excellent robustness in material selection and design gap, and is capable of long-term operation without external power sources. The effectiveness and self-sensing capability of SST-DTRB under variable speeds are validated using a wind turbine test bench. High-accuracy bearing fault diagnosis under multiple conditions is achieved based on time-frequency transformation and deep residual neural networks. The proposed SST-DTRB provides in situ self-powered sensing capability for wind turbines and offers new insights in the development of intelligent sensing systems.}, archive = {J_ADVS}, author = {Song Wang and Xiantao Zhang and Tenghao Ma and Yun Kong and Shuai Gao and Qinkai Han}, doi = {10.1002/advs.202500981}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500981}, shortjournal = {Adv. Sci.}, title = {Symmetrical triboelectric in situ self-powered sensing and fault diagnosis for double-row tapered roller bearings in wind turbines: An integrated and real-time approach}, volume = {12}, year = {2025}, }
• (2025). AKT1E17K-interacting lncRNA SVIL-AS1 promotes AKT1 oncogenic functions by preferentially blocking AKT1E17K dephosphorylation. ADVS, 12(19), 2500919. (www)

  @article{ , abstract = {AKT1 E17K is a gain-of-function mutation that constitutively activates the PI3K-AKT pathway. However, how AKT1 E17K is regulated in cancer pathogenesis remains elusive. Here, RNA immunoprecipitation sequencing (RIP-seq) is performed to interrogate the AKT1 E17K -interacting lncRNAs and identify that SVIL-AS1 preferentially binds to AKT1 E17K rather than AKT1 WT proteins. It is found that SVIL-AS1 enhances AKT1 phosphorylation and downstream signaling. SVIL-AS1 knockdown dramatically inhibits the growth of AKT1 E17K cells in vitro and in vivo. Notably, AKT1 and SVIL-AS1 interaction is AKT1 phosphorylation-dependent. SVIL-AS1 also interacts with PPP2R2A, a subunit of phosphatase PP2A holoenzyme, and blocks the binding of PPP2R2A to AKT1 E17K to prevent AKT1 dephosphorylation. Moreover, AKT1 E17K cells are not effectively inhibited by the allosteric AKT inhibitor, whereas silencing SVIL-AS1 sensitizes AKT1 E17K cells to AKT1 allosteric inhibitor, as well as the PI3Kα inhibitor. In breast cancer tissues, SVIL-AS1 is highly expressed and associated with p-AKT1 level and poor prognosis of patients. Together, the findings discover a novel lncRNA regulator of mutant oncoprotein which preferentially prevents AKT1 E17K dephosphorylation. Targeting SVIL-AS1 may help to improve the responses to inhibitors of the PI3K-AKT pathway, especially in AKT1 E17K mutant tumors.}, archive = {J_ADVS}, author = {Jingyi Wang and Wenying Chen and Qianying Li and Ruiyi Yang and Xiaorong Lin and Ping Han and Xiaoming Huang and Hai Hu and Man-Li Luo}, doi = {10.1002/advs.202500919}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500919}, shortjournal = {Adv. Sci.}, title = {AKT1E17K-interacting lncRNA SVIL-AS1 promotes AKT1 oncogenic functions by preferentially blocking AKT1E17K dephosphorylation}, volume = {12}, year = {2025}, }
• (2025). Data-driven design of mechanically hard soft magnetic high-entropy alloys. ADVS, 12(19), 2500867. (www)

  @article{ , abstract = {The design and optimization of mechanically hard soft magnetic materials, which combine high hardness with magnetically soft properties, represent a critical frontier in materials science for advanced technological applications. To address this challenge, a data-driven framework is presented for exploring the vast compositional space of high-entropy alloys (HEAs) and identifying candidates optimized for multifunctionality. The study employs a comprehensive dataset of 1 842 628 density functional theory calculations, comprising 45 886 quaternary and 414 771 quinary equimolar HEAs derived from 42 elements. Using ensemble learning, predictive models are integrated to capture the relationships between composition, crystal structure, mechanical, and magnetic properties. This framework offers a robust pathway for accelerating the discovery of next-generation alloys with high hardness and magnetic softness, highlighting the transformative impact of data-driven strategies in material design.}, archive = {J_ADVS}, author = {Mian Dai and Yixuan Zhang and Xiaoqing Li and Stephan Schönecker and Liuliu Han and Ruiwen Xie and Chen Shen and Hongbin Zhang}, doi = {10.1002/advs.202500867}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500867}, shortjournal = {Adv. Sci.}, title = {Data-driven design of mechanically hard soft magnetic high-entropy alloys}, volume = {12}, year = {2025}, }
• (2025). Direct visualization and quantitative insights into the formation and phase evolution of cu nanoparticles via in situ liquid phase 4D-STEM. ADVS, 12(19), 2500706. (www)

  @article{ , abstract = {Copper (Cu)-based nanomaterials are one of the most efficient heterogeneous electrocatalysts for the CO 2 reduction reaction. However, their selectivity and stability are strongly determined by their morphology, crystal structure, composition, grain size, grain boundary density, etc. Hence, gaining quantitative insights into their dynamic evolution under synthesis and/or working conditions is critical for developing optimal Cu-based electrocatalysts and unveiling their structure-property relationship. In this work, the possibility of addressing these issues is demonstrated by integrating in situ liquid phase transmission electron microscopy (LP-TEM) with 4D scanning transmission electron microscopy (4D-STEM). Here, the dynamic morphology and phase evolution of Cu nanoparticles during electrodeposition and electrooxidation processes are revealed in liquid. Virtual imaging and selected area electron diffraction provide novel insights into the evolution of defective nanocrystalline Cu nanoparticles during electrodeposition. It is shown that virtual off-axis dark field imaging can be used to map the distribution of Cu 2 O and Cu within partially oxidized Cu nanoparticles, opening new opportunities for quantitatively probing electrocatalysts under operando conditions.}, archive = {J_ADVS}, author = {Ningyan Cheng and Hongyu Sun and Yevheniy Pivak and Christian H. Liebscher}, doi = {10.1002/advs.202500706}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500706}, shortjournal = {Adv. Sci.}, title = {Direct visualization and quantitative insights into the formation and phase evolution of cu nanoparticles via in situ liquid phase 4D-STEM}, volume = {12}, year = {2025}, }
• (2025). A copper-based photothermal-responsive nanoplatform reprograms tumor immunogenicity via self-amplified cuproptosis for synergistic cancer therapy. ADVS, 12(19), 2500652. (www)

  @article{ , abstract = {Studies show that intracellular accumulation of copper ions causes cuproptosis, potentially enhancing anticancer immunity. However, the induction of cuproptosis inevitably faces challenges due to low intracellular copper deliver efficiency and collateral damage to normal tissues. This paper presents a self-amplified cuproptosis nanoplatform (CEL NP) composed of Cu 2− X S hollow nanospheres (HNSs), elesclomol (ES), and phase-change material lauric acid (LA). Under NIR-II laser irradiation, the photothermal energy generated by Cu 2− X S HNSs melts LA, facilitating the precise release of ES and copper ions within the tumor microenvironment. Notably, ES can traverse the cell membrane and form ES-Cu(II) complexes, thereby enhancing copper delivery within tumor cells. Excess Cu(II) also reacts with endogenous glutathione, reducing its inhibitory effect on cuproptosis. Ultimately, this amplified cuproptosis effect can activate immunogenic cell death, eliciting a robust immune response and promoting tumor suppression. The CEL NP-mediated release of ES and copper ions offers a novel approach for anticancer therapy through cuproptosis induction.}, archive = {J_ADVS}, author = {Runzi Cheng and Zhenhao Li and Weican Luo and Hongwu Chen and Tingting Deng and Zhenqi Gong and Qing Zheng and Baizhi Li and Yongming Zeng and Huaiming Wang and Cong Huang}, doi = {10.1002/advs.202500652}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500652}, shortjournal = {Adv. Sci.}, title = {A copper-based photothermal-responsive nanoplatform reprograms tumor immunogenicity via self-amplified cuproptosis for synergistic cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Autocrine GDF10 inhibits hepatic stellate cell activation via BMPR2/ALK3 receptor to prevent liver fibrosis. ADVS, 12(19), 2500616. (www)

  @article{ , abstract = {Hepatic stellate cells (HSCs) play a central role in the development of liver fibrosis, and their activation is controlled by a complex interplay of autocrine/paracrine signals within the liver microenvironment. Here, we show that growth differentiation factor 10 (GDF10) is specifically expressed by HSCs in both mouse and human livers, and its expression is reduced in activated HSCs. Loss of GDF10 function promotes HSC activation and exacerbates liver fibrosis in mice, while gain of GDF10 function alleviates this pathological condition. Mechanistically, autocrine GDF10 binds to BMPR2/ALK3 receptor to elicit SMAD1/5/8-SMAD7 signaling pathway in HSCs. Activated SMAD1/5/8-SMAD7 signaling pathway then inhibits the TGF-β-SMAD2/3 signaling transduction, which is essential for HSC activation. Moreover, recombinant GDF10 protein treatment suppresses HSC activation and alleviates liver fibrosis in mice. In conclusion, GDF10 is an autocrine suppressor of HSC activation and a potential therapeutic target for the treatment of liver fibrosis.}, archive = {J_ADVS}, author = {Yinliang Zhang and Xiaochen Gai and Yuhui Li and Zuoyu Chen and Xi Zhang and Wei Qiao and Ping Qiu and Chunyuan Du and Sufang Sheng and Jingran Hao and Yujie Zhang and Heng Fan and Xiaorong Li and Ming Liu and Jun Zhang and Zhe Pan and Yongsheng Chang}, doi = {10.1002/advs.202500616}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500616}, shortjournal = {Adv. Sci.}, title = {Autocrine GDF10 inhibits hepatic stellate cell activation via BMPR2/ALK3 receptor to prevent liver fibrosis}, volume = {12}, year = {2025}, }
• (2025). Neuromorphic computing using synaptic plasticity of supercapacitors. ADVS, 12(19), 2500521. (www)

  @article{ , abstract = {Neuromorphic computing systems convert multimodal signals to electrical responses for artificial intelligence recognition. Energy is consumed during both the response enhancement and depression, making the systems suffer from high energy consumption. This study presents a neuromorphic computing pathway based on supercapacitors. MXene Ti₃C₂Tx supercapacitors are fabricated and convert current stimuli to voltage responses. The response enhancement and depression are tunable through adjusting charging and discharging current stimuli, thus exhibiting synaptic plasticity. Typical synaptic behaviors are demonstrated, including short-term memory, long-term memory, paired-pulse facilitation, and learning experience. Next, the voltage responses are used to recognize Braille numbers represented by 3 × 4 arrays. A charging/discharging current pulse train representing each Braille array is applied to the supercapacitor. The voltage responses are collected and converted to 12-pixel greyscale images. Once the images representing Braille numbers 0–9 are input into artificial neural networks and deep diffraction neural networks, 100% accuracy can be achieved for recognizing the ten numbers. Because energy is stored during response enhancement in the supercapacitor and released once the response declines, this research demonstrates the potential applications of energy storage devices in neuromorphic computing, providing an innovative way to develop energy-efficient brain-like computing systems.}, archive = {J_ADVS}, author = {Ling Wang and Xing Liu and Guangcai Zhang and Fuxun Qi and Xi Chen}, doi = {10.1002/advs.202500521}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500521}, shortjournal = {Adv. Sci.}, title = {Neuromorphic computing using synaptic plasticity of supercapacitors}, volume = {12}, year = {2025}, }
• (2025). In situ TEM studies of tunnel-structured materials for alkali metal-ion batteries. ADVS, 12(19), 2500513. (www)

  @article{ , abstract = {Tunnel-structured materials have garnered significant attention as promising candidates for high-performance rechargeable batteries, owing to their unique structural characteristics that facilitate efficient ionic transport. However, understanding the dynamic processes of ionic transport within these tunnels is crucial for their further development and performance optimization. Analytical in situ transmission electron microscopy (TEM) has demonstrated its effectiveness as a powerful tool for visualizing the complex ionic transport processes in real time. In this review, we summarize the state-of-the-art in situ tracking of ionic transport processes in tunnel-structured materials for alkali metal-ion batteries (AMIBs) by TEM observation at the atomic scale, elucidating the fundamental issues pertaining to phase transformations, structural evolution, interfacial reactions and degradation mechanisms. This review covers a wide range of electrode and electrolyte materials used in AMIBs, highlighting the versatility and general applicability of in situ TEM as a powerful tool for elucidating the fundamental mechanisms underlying the performance of AMIBs. Furthermore, this work critically discusses current challenges and future research directions, offering perspectives on the development of next-generation battery materials through advanced in situ characterization techniques.}, archive = {J_ADVS}, author = {Shuge Dai and Chenke Yang and Ye Wang and Yunrui Jiang and Longhui Zeng}, doi = {10.1002/advs.202500513}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500513}, shortjournal = {Adv. Sci.}, title = {In situ TEM studies of tunnel-structured materials for alkali metal-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Poly(pentacenetetrone) as a high-capacity cathode for sodium batteries. ADVS, 12(19), 2500484. (www)

  @article{ , abstract = {Sodium batteries (SBs) are a promising alternative to lithium-ion batteries (LIBs) due to the abundance, cost-effectiveness, and environmental sustainability of sodium. However, the larger ionic radius of Na + leads to challenges in electrode stability, limiting the performance of conventional inorganic cathode materials. Redox-active organic compounds, particularly π-conjugated quinones, have emerged as a viable alternative, due to their tunable electrochemical properties, structural flexibility, and enhanced compatibility with Na + . Despite their advantages, many quinone-based cathodes suffer from limited cycling stability and solubility issues. Here, the synthesis and characterization of poly(pentacenetetrone) (PPT) as a high-capacity cathode material for SBs is reported. PPT exhibits a high theoretical specific capacity ( Q tsp = 319 mAh g⁻¹) and achieves an experimental specific capacity ( Q sp ) of 314 mAh g⁻¹ at 0.2C, with remarkable cycling stability. At 2C, the capacity remains at 260 mAh g⁻¹, retaining 92% after 500 cycles. PPT demonstrates excellent rate capability with 98% capacity retention after extended cycling. These findings highlight the potential of PPT as a high-performance cathode material for sodium batteries, addressing critical challenges in scalability and long-term stability for next-generation energy storage systems.}, archive = {J_ADVS}, author = {Chinmaya Mirle and Philipp A. Schuster and Luis Kolb and Litwin Jacob and Alexander J.C. Kuehne}, doi = {10.1002/advs.202500484}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500484}, shortjournal = {Adv. Sci.}, title = {Poly(pentacenetetrone) as a high-capacity cathode for sodium batteries}, volume = {12}, year = {2025}, }
• (2025). Room-temperature operable, fully recoverable ethylene gas sensor via pulsed electric field modulation. ADVS, 12(19), 2500389. (www)

  @article{ , abstract = {Ethylene (C 2 H 4 ) is an important plant hormone, and its concentration can be used as an essential indicator of fruit quality. However, C 2 H 4 is a non-polar gas with a relatively stable structure, making it challenging to detect and desorb without heating or irradiation. Here, a pulsed electric field modulation mode for non-polar gas detection is proposed, which enables fast and complete recovery of sensors at room temperature. Compared to the nearly impossible desorption without electric field assistance, the recovery time for 9 ppm C 2 H 4 can be reduced to 78 s when the +60 V pulse gate voltage is applied, which is nearly equivalent to the recorded values under heating or irradiation (50 s under 250 °C). Most crucially, with the help of a gate-induced electric field, the sensor achieves complete desorption within 100 s. This work offers a new approach for fast non-polar gas detection at room temperature and on-chip integration of gas sensors.}, archive = {J_ADVS}, author = {Zeyu Zhang and Bolang Cheng and Yong Zhang}, doi = {10.1002/advs.202500389}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500389}, shortjournal = {Adv. Sci.}, title = {Room-temperature operable, fully recoverable ethylene gas sensor via pulsed electric field modulation}, volume = {12}, year = {2025}, }
• (2025). Correction to “Intra-operative definition of glioma infiltrative margins by visualizing immunosuppressive tumor-associated macrophages”. ADVS, 12(19), 2500244. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202500244}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500244}, shortjournal = {Adv. Sci.}, title = {Correction to “Intra-operative definition of glioma infiltrative margins by visualizing immunosuppressive tumor-associated macrophages”}, volume = {12}, year = {2025}, }
• (2025). Achieving high-performance transcranial ultrasound transmission through mie and fano resonance in flexible metamaterials. ADVS, 12(19), 2500170. (www)

  @article{ , abstract = {Transcranial ultrasound holds great potential in medical applications. However, the effective transmission of ultrasound through the skull remains challenging due to the acoustic impedance mismatch, as well as the non-uniform thickness, and the curved surface. To overcome these challenges, this work introduces an innovative Mie-resonance flexible metamaterial (MRFM), which consists of periodically arranged low-speed micropillars embedded within a high-speed flexible substrate. The MRFM generates Mie-resonance, which couples with the skull to form Fano resonance, thereby enhancing ultrasound transmittance through the skull. Simulation results demonstrate that the proposed resonance solution significantly increases transcranial ultrasound transmittance from 33.7% to 75.2% at 0.309 MHz. For the fabrication of the MRFM, porous nickel foam is used as the Mie micropillars, and agarose hydrogel serves as the flexible substrate. Experimental results demonstrate enhanced ultrasound transmittance from 20.6% to 73.3% at 0.33 MHz with the MRFM, which shows good agreement with the simulation results, further validating the effectiveness of the design. The simplicity, tunability, and flexibility of the MRFM represent a significant breakthrough, addressing the limitations of conventional rigid metamaterials. This work lays a solid theoretical and experimental foundation for advancing the clinical application of transcranial ultrasound stimulation and neuromodulation.}, archive = {J_ADVS}, author = {Jie Chen and Bing Liu and Genshen Peng and Linming Zhou and Chengwei Tan and Jiale Qin and Juan Li and Zijian Hong and Yongjun Wu and Minghui Lu and Feiyan Cai and Yuhui Huang}, doi = {10.1002/advs.202500170}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500170}, shortjournal = {Adv. Sci.}, title = {Achieving high-performance transcranial ultrasound transmission through mie and fano resonance in flexible metamaterials}, volume = {12}, year = {2025}, }
• (2025). Targeting antigen-presenting cells to enhance the tumor-spleen immunity cycle through liposome-neoantigen vaccine. ADVS, 12(19), 2500021. (www)

  @article{ , abstract = {Effective immune responses in both the spleen and the tumor microenvironment are crucial for cancer immunotherapy. However, delivery of neoantigen peptide vaccines to antigen-presenting cells (APCs) at these sites remains challenging. In this study, LNPs D18 , a cationic liposomal formulation that targets and enhances APC uptake at both sites without modifying the targeting ligands is developed. By co-delivering tumor-specific neoantigens and a cholesterol-coupled toll-like receptor 9 (TLR9) agonist within LNP-vax D18 , an approximately 60-fold increase in dendritic cell uptake compared to neoantigen-adjuvant mixtures is achieved. Intravenous administration of the liposome-neoantigen peptide vaccine targets both the spleen and the tumor, boosting splenic DC activation, increasing M1-type tumor-associated macrophages, and elevating tumor cytokine levels. This reshapes the tumor microenvironment, enhancing IFN-γ-producing CD8 + T cells and TCF1 + CD8 + T cells within tumors. These outcomes significantly inhibit established tumor growth compared to nontargeted lipid-based nanovaccine formulations, resulting in improved survival in orthotopic hepatocellular carcinoma and colorectal cancer models. The findings highlight the importance of targeting APCs in both the spleen and tumors to optimize the therapeutic efficacy of liposome-neoantigen vaccines in cancer treatment.}, archive = {J_ADVS}, author = {Yu Xu and Bing Wang and Yue Huang and JianPing Liao and Chenyi Wu and Chenxi Zhou and Zishi Kang and Shiyang Jiang and Bing-Chen Wu and Da Zhang and Ruihua Xu and Xiaolong Liu and Feng Wang}, doi = {10.1002/advs.202500021}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2500021}, shortjournal = {Adv. Sci.}, title = {Targeting antigen-presenting cells to enhance the tumor-spleen immunity cycle through liposome-neoantigen vaccine}, volume = {12}, year = {2025}, }
• (2025). Oxidized ti single atoms and Co₃O₄ with abundant oxygen vacancies collaborating with adjacent pd sites for an efficient and stable oxygen reduction reaction. ADVS, 12(19), 2417789. (www)

  @article{ , abstract = {The current study addresses these key issues by providing the ensemble sites and creating oxygen vacancies in the oxidized Ti-single atoms. Here we report a novel heterogeneous catalyst comprising oxidized Ti-single atoms uniformly coated on the cobalt-oxide-supported Pd nanoparticles (denoted as CP@Ti-1), where the oxygen vacancies are introduced in oxidized Ti-single atoms as well as cobalt-oxide support. As-developed CP@Ti-1 catalyst demonstrates remarkable ORR activity with a mass activity (MA) of 9,725 mAmg Ti −1 at 0.85 V vs RHE and 1,244 mAmg Ti −1 at 0.90 V vs RHE in alkaline conditions. These values mark significant improvements over the commercial J.M.-Pt/C catalyst, outperforming it by 145- and 50-fold, respectively. Additionally, the CP@Ti-1 catalyst shows exceptional durability, maintaining 100% of its initial performance after 20, 000 cycles of accelerated degradation test (ADT). In-situ X-ray absorption spectroscopy (XAS) analysis reveals that the catalyst design promotes synergistic interactions between oxygen vacancies in Ti/Co atoms and adjacent Pd domains, facilitating key reactions in ORR such as oxygen splitting and hydroxide ion formation, respectively, enhancing overall catalytic efficiency. These insights promise significant advancements in both scientific research and industrial applications of ORR catalysis.}, archive = {J_ADVS}, author = {Hong-Wei Chang and Thomas Yang and Che Yan and Po-Han Chiu and Chi-Ying Wu and Hung-Wei Yen and Dinesh Bhalothia and Kaun-Wen Wang and Po-Chun Chen and Tsan-Yao Chen}, doi = {10.1002/advs.202417789}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2417789}, shortjournal = {Adv. Sci.}, title = {Oxidized ti single atoms and Co₃O₄ with abundant oxygen vacancies collaborating with adjacent pd sites for an efficient and stable oxygen reduction reaction}, volume = {12}, year = {2025}, }
• (2025). Electrical manipulation of field-free magnetization switching driven by spin-orbit torque in amorphous gradient-Mn3Sn. ADVS, 12(19), 2417621. (www)

  @article{ , abstract = {Switching the magnetization without an assisted magnetic field is crucial for the application of spin-orbit torque (SOT) devices. However, the realization of field-free magnetization switching usually calls for intricate design and growth of heterostructure. In this study, it is found that the amorphous Mn 3 Sn can generate a highly efficient spin current with a strong z -direction polarization component due to its spontaneous composition gradient, which switches the perpendicular magnetization in the absence of an external field. The SOT efficiency of gradient-Mn 3 Sn can be reversibly modulated by the ionic liquid gating based on the migration of hydrogen ions, which reverses the polarity of field-free magnetization switching and allows the realization of 16 binary Boolean logic functions in a single device by pure electrical methods. These results not only offer a very convenient route to field-free magnetization switching but also can promote the development of in-memory computing for spintronic devices.}, archive = {J_ADVS}, author = {Mingfang Zhang and Bin Cui and Taiyu An and Xue Ren and Weikang Liu and Xiangxiang Zhao and Hehe Ding and Zhiyu Zhang and Xu Zhang and Weijie Kuai and Guangjun Zhou and Bin Cheng and Liang Liu and Jifan Hu}, doi = {10.1002/advs.202417621}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2417621}, shortjournal = {Adv. Sci.}, title = {Electrical manipulation of field-free magnetization switching driven by spin-orbit torque in amorphous gradient-Mn3Sn}, volume = {12}, year = {2025}, }
• (2025). Outermost cationic surface charge of layer-by-layer films prevents endothelial cells migration for cell compartmentalization in three-dimensional tissues. ADVS, 12(19), 2417538. (www)

  @article{ , abstract = {Tissues and organs possess an organized cellular arrangement that enables their unique functions. However, conventional three-dimensional (3D) encapsulation techniques fail to recapitulate this complexity due to the cell migration during cell culture. In biological tissues, basement membranes (BMs) are essential to mechanically support cellular organization. This study finds that a positively charged outermost surface of multilayered nanofilms, fabricated through layer-by-layer assembly of poly- l -lysine (PLL) and dextran (Dex) via hydrogen bonds, stimulates the barrier functions of BMs. This type of artificial BM (A-BM) demonstrates enhanced barrier properties in comparison to other types of A-BMs composed of BM components such as collagen type IV and laminin. Such an enhancement is potentially associated with the outermost cationic layer, which inhibits the sprouting of endothelial cells (ECs) and effectively prevents EC migration over a 14-d period, aligning with the formation timeline of natural BMs in 3D tissues. Finally, 3D organized vascular channels are successfully engineered with the support of shape-adaptable PLL/Dex nanofilms. This approach offers a guideline for engineering organized 3D tissue models by regulating cell migration, which can provide reliable platforms for in vitro permeability assay of new drugs or drug delivery carriers.}, archive = {J_ADVS}, author = {Jinfeng Zeng and Sven Heilig and Matthias Ryma and Jürgen Groll and Congju Li and Michiya Matsusaki}, doi = {10.1002/advs.202417538}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2417538}, shortjournal = {Adv. Sci.}, title = {Outermost cationic surface charge of layer-by-layer films prevents endothelial cells migration for cell compartmentalization in three-dimensional tissues}, volume = {12}, year = {2025}, }
• (2025). Highly selective electroreduction of CO2 to CH4 on Cu–Pd alloy catalyst: The role of palladium-adsorbed hydrogen species and blocking effect. ADVS, 12(19), 2417247. (www)

  @article{ , abstract = {Electroreduction of CO 2 to chemical fuels offers a promising strategy for controlling the global carbon balance and addressing the need for the storage of intermittent renewable energy. In this work, it is demonstrated that tuning adjacent active sites enables the selection of different reaction pathways for generating C 1 or C 2 products during the electroreduction of CO 2 . Cu and Cu–Pd alloy catalysts with different atomic ratios are synthesized and investigated to elucidate their different electroreduction selectivities for CO 2 electroreduction. Cu catalyst favors the formation of C 2 products since the neighboring active Cu sites are beneficial for coupling adjacently adsorbed * CO and * CHO intermediates. Cu alloyed with Pd introduces a blocking effect and increases the intermolecular distance between adjacent adsorbed * CO and * CHO intermediates. Therefore the selectivity for the C 2 H 4 pathway decreas while the CH 4 pathway is enhanced. Moreover, the existence of adsorbed * H species on Pd atoms also played a significant role in boosting CO 2 electroreduction to CH 4 by facilitating the hydrogenation of * CO intermediates. This work reveals the key role of * H species adsorbed on Pd atoms and the blocking effect between active sites for CH 4 formation, which is helpful for the design of copper-based catalysts for desired products.}, archive = {J_ADVS}, author = {Jinyan Huang and Ye Yang and Xuexue Liang and Bing Chen and Yue Shen and Yan Chen and Jielian Yang and Yinglin Yu and Fang Huang and Huibing He and Peican Chen and Liya Zhou and Anxiang Guan}, doi = {10.1002/advs.202417247}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2417247}, shortjournal = {Adv. Sci.}, title = {Highly selective electroreduction of CO2 to CH4 on Cu–Pd alloy catalyst: The role of palladium-adsorbed hydrogen species and blocking effect}, volume = {12}, year = {2025}, }
• (2025). Manipulation of ferroic orders via continuous biaxial strain engineering in multiferroic bismuth ferrite. ADVS, 12(19), 2417165. (www)

  @article{ , abstract = {Continuous strain engineering of multiferroics not only enhances understanding of their properties but also guides the optimization of their performances for use in electronic, optical, and magnetic devices. However, due to technical challenges in real-time monitoring of the ferroic orders, the precise evolution process remains unclear. Here, the evolution of the ferroelectric (FE) and antiferromagnetic (AFM) orders are revealed in multiferroic freestanding BiFeO 3 films under sequential and anisotropic biaxial strain, using rotational anisotropy second harmonic generation (RA-SHG) technology and first-principles calculations. The change and recovery of RA-SHG patterns illustrate the reversible control of the in-plane FE polarization in the films by sequential strain application. The in-plane FE direction can be manipulated within ≈4° by strain along the (100) and (010) directions, while the AFM order is more significantly affected, with ≈8° rotation in RA-SHG patterns. This research unveils the appearance of new SHG peaks in freestanding BFO films under strain and shows that they evolve independently of FE-induced SHG linked to lattice changes, suggesting a spin structure-related variation. This work paves a new way for studying of strain-manipulated 2D multiferroics and highlights the promise of freestanding perovskite films as low-dimensional multifunctional devices.}, archive = {J_ADVS}, author = {Jiesu Wang and Shuai Xu and Sebastian Meyer and Shiyao Wu and Subhadeep Bandyopadhyay and Xu He and Qiyuan Miao and Sisi Huang and Pengzhan Li and Kun Zhao and Er-Jia Guo and Chen Ge and Bertrand Dupé and Philippe Ghosez and Kai Chang and Kuijuan Jin}, doi = {10.1002/advs.202417165}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2417165}, shortjournal = {Adv. Sci.}, title = {Manipulation of ferroic orders via continuous biaxial strain engineering in multiferroic bismuth ferrite}, volume = {12}, year = {2025}, }
• (2025). ALKBH3-mediated M1A demethylation of METTL3 endows pathological Fibrosis:Interplay between M1A and M6A RNA methylation. ADVS, 12(19), 2417067. (www)

  @article{ , abstract = {Epigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m 1 A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro-fibrotic effect in pathological skin fibrosis by reshaping N6-methyladenosine (m 6 A) RNA modification pattern. First, ALKBH3 exhibited specific upregulation within hypertrophic scars (HTS), accompanied by N1-methyladenosine (m 1 A) hypomethylation. Moreover, multiomics analyses identified METTL3, a critical writer enzyme involved in m 6 A modification, as a downstream candidate target of ALKBH3. Therapeutically, ablation of ALKBH3 inhibited the progression of HTS both in vitro and in vivo, while exogenous replenishment of METTL3 counteracted this antifibrotic effect. Mechanistically, ALKBH3 recognizes the m 1 A methylation sites and prevents YTHDF2-dependent mRNA decay of METTL3 transcript. Subsequently, METTL3 stabilizes collagen type I alpha 1 chain ( COL1A1 ) and fibronectin1 ( FN1 ) mRNAs, two major components of extracellular matrix, and therefore eliciting the pathological transformation of HTS. This observation bridges the understanding of the link between m 1 A and m 6 A methylation, the two fundamental RNA modifications, underscoring the participation of “RNA methylation crosstalk” in pathological events.}, archive = {J_ADVS}, author = {Liying Tu and Shuchen Gu and Ruoqing Xu and En Yang and Xin Huang and Hsin Liang and Shenying Luo and Haizhou Li and Yixuan Zhao and Tao Zan}, doi = {10.1002/advs.202417067}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2417067}, shortjournal = {Adv. Sci.}, title = {ALKBH3-mediated M1A demethylation of METTL3 endows pathological Fibrosis:Interplay between M1A and M6A RNA methylation}, volume = {12}, year = {2025}, }
• (2025). Defect spinel aluminum molybdenum sulfide: A dual-function catalyst for polysulfide conversion and aluminum intercalation in Aluminum–Sulfur batteries. ADVS, 12(19), 2417061. (www)

  @article{ , abstract = {Aluminum–sulfur batteries (ASBs) are regarded as promising energy storage devices due to their cost-effectiveness and safety. However, ASBs suffer from problems of polysulfide shuttling and short lifetimes, which restrict their practical applications. In this work, defect spinel Aluminum molybdenum sulfide (AlMo 4 S 8 ) embedded in carbon nanotubes synthesized via solid-state reaction is applied to ASBs. The carbon nanotube-connected spinel AlMo 4 S 8 material effectively mitigates polysulfide shuttling while also contributing its own capacity in ASBs. Besides, AlMo 4 S 8 serves as a “bi-directional catalyst” with bimetallic active sites to increase the ion transport pathway, effectively facilitating the reduction of polysulfides and the oxidation of Al 2 S 3 . The ASBs with AlMo 4 S 8 /CNTs@S cathode exhibit excellent electrochemical performance with high specific capacity (304.3 mAh g −1 at 500 mA g −1 ). The soft pack batteries fabricated with AlMo 4 S 8 /CNTs@S cathode (sulfur loading of 3.0 mg cm −2 ) maintain a stable capacity for more than 50 cycles.}, archive = {J_ADVS}, author = {Qiuping Zhou and Yi Liu and Huayan Zhang and Chenlong Feng and Xinyuan Jiang and Guang Yang and Yongjun He and Ming Chen and Guowang Diao and Lubin Ni}, doi = {10.1002/advs.202417061}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2417061}, shortjournal = {Adv. Sci.}, title = {Defect spinel aluminum molybdenum sulfide: A dual-function catalyst for polysulfide conversion and aluminum intercalation in Aluminum–Sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). Single-cell and spatial transcriptomics reveals a stereoscopic response of rice leaf cells to magnaporthe oryzae infection. ADVS, 12(19), 2416846. (www)

  @article{ , abstract = {Infection by the fungal pathogen Magnaporthe oryzae elicits dynamic responses in rice. Utilizing an integrated approach of single-cell and spatial transcriptomics, a 3D response is uncovered within rice leaf cells to M. oryzae infection. A comprehensive rice leaf atlas is constructed from 236 708 single-cell transcriptomes, revealing heightened expression of immune receptors, namely Pattern Recognition Receptors (PRRs) and Nucleotide-binding site and leucine-rich repeat (NLRs) proteins, within vascular tissues. Diterpene phytoalexins biosynthesis genes are dramatically upregulated in procambium cells, leading to an accumulation of these phytoalexins within vascular bundles. Consistent with these findings, microscopic observations confirmed that M. oryzae is prone to target leaf veins for invasion, yet is unable to colonize further within vascular tissues. Following fungal infection, basal defenses are extensively activated in rice cells, as inferred from trajectory analyses. The spatial transcriptomics reveals that rice leaf tissues toward leaf tips display stronger immunity. Characterization of the polarity gene OsHKT9 suggests that potassium transport plays a critical role in resisting M. oryzae infection by expression along the longitudinal axis, where the immunity is stronger toward leaf tip. This work uncovers that there is a cell-specific and multi-dimensional (local and longitudinal) immune response to a fungal pathogen infection.}, archive = {J_ADVS}, author = {Wei Wang and Xianyu Zhang and Yong Zhang and Zhe Zhang and Chang Yang and Wen Cao and Yuqin Liang and Qinzheng Zhou and Qian Hu and Yimai Zhang and Yu Wang and Yingying Xing and Wenfeng Qian and Nan Yao and Ning Xu and Jun Liu}, doi = {10.1002/advs.202416846}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2416846}, shortjournal = {Adv. Sci.}, title = {Single-cell and spatial transcriptomics reveals a stereoscopic response of rice leaf cells to magnaporthe oryzae infection}, volume = {12}, year = {2025}, }
• (2025). Halofuginone disrupted collagen deposition via mTOR-eIF2α-ATF4 axis to enhance chemosensitivity in ovarian cancer. ADVS, 12(19), 2416523. (www)

  @article{ , abstract = {The interplay between cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM) mediates progress, metastasis, and therapy resistance. However, strategy of targeting ECM remodeling to enhance chemosensitivity in ovarian cancer remains elusive. Here, a 22-gene matrisome signature predicts chemotherapy response and survival in ovarian cancer. The dense, collagen-rich ECM secreted by CAFs harbors more M2 tumor-associated macrophages (TAMs) than the looser ECM based on single cell RNA-seq (scRNA-seq) of ovarian cancer, suggesting the promising approach of targeting collagen to remodel ECM. An integrated analysis identifies collagen type I alpha 1 chain (COL1A1) as a major component of the ECM that contributes to chemoresistance and poor prognosis, highlighting its potential as a therapeutic target. Halofuginone (HF), a clinically active derivative of febrifugine, is identified as a COL1A1-targeting natural compound by screening the Encyclopedia of Traditional Chinese Medicine (ETCM). Mechanistically, HF inhibits COL1A1 production via the mTOR-eIF2α-ATF4 axis in CAFs. Notably, HF disrupts collagen deposition and promotes CD8+ T cell infiltration, partially via M2-M1 macrophage polarization to enhance chemosensitivity. Overall, the findings suggest that HF combined with chemotherapy is a promising and effective treatment for ovarian cancer.}, archive = {J_ADVS}, author = {Wenxin Li and Yenan Wu and Yanan Zhang and Wenyan Gao and Xin Li and Haixia Luo and Mengmeng Lu and Zhihua Liu and Aiping Luo}, doi = {10.1002/advs.202416523}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2416523}, shortjournal = {Adv. Sci.}, title = {Halofuginone disrupted collagen deposition via mTOR-eIF2α-ATF4 axis to enhance chemosensitivity in ovarian cancer}, volume = {12}, year = {2025}, }
• (2025). Taming lithium nucleation and growth on cu current collector by electrochemical activation of ZnF2 layer. ADVS, 12(19), 2416426. (www)

  @article{ , abstract = {Lithium-metal anodes are essential for the advancement of next-generation batteries. However, their practical use is largely hindered by the uncontrollable growth of dendrites and intricate problems associated with fabricating anodes that meet capacity requirements. Here, it is demonstrated that an ultrathin ZnF 2 layer deposited on the copper foil can produce a novel and efficient current collector to address these challenges. It is observed that ZnF 2 can be transformed into LiZn alloy and LiF salt in one step by simple electrochemical activation. The resulting LiZn alloy exhibits high lithiophilicity, which reduces overpotential and promotes uniform lithium nucleation, while the LiF salt enhances the solid electrolyte interphase, ensuring uniform lithium growth. This synergistic effect led to a dendrite-free, densely packed lithium anode with an extended lifespan, achieving over 900 h in symmetric cells at a high current density of 3 mA cm −2 and a high cut-off capacity of 3 mAh cm −2 . Furthermore, full cells utilizing the lithium anode (Li capacity of 6 mAh cm −2 ) paired with LiNi 0.8 Mn 0.1 Co 0.1 O 2 cathodes (mass loading of 11.5 mg cm −2 ) demonstrates drastically improved rate capability and excellent cycling stability. This approach holds great promise for developing safer and more efficient lithium-metal-based batteries for future energy storage solutions.}, archive = {J_ADVS}, author = {Viet Phuong Nguyen and Hyung Cheoul Shim and Young-Woon Byeon and Jae-Hyun Kim and Seung-Mo Lee}, doi = {10.1002/advs.202416426}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2416426}, shortjournal = {Adv. Sci.}, title = {Taming lithium nucleation and growth on cu current collector by electrochemical activation of ZnF2 layer}, volume = {12}, year = {2025}, }
• (2025). ISG15 enhances the activity of γ-glutamate cysteine ligase to suppress apoptosis in high fat diet-promoted hepatocellular carcinoma. ADVS, 12(19), 2416401. (www)

  @article{ , abstract = {Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High-fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis. How HCC cells regulate ROS level and escape the cytotoxic effects of high fat diet (HFD) stress remains unclear. Herein, this work reports a critical anti-ROS/apoptotic role of the ubiquitin-like protein interferon stimulated gene 15 (ISG15) in HFD-promoted HCC. In mouse models and clinical HCC samples, upregulation of ISG15 is associated with hepatic steatosis. Notably, upregulated ISG15 elevates cellular glutathione levels, which subsequently reduces ROS accumulation and confers resistance to apoptosis in HCC cells. In diethylnitrosamine-induced HCC mouse model, HFD-feeding promotes HCC progression in wildtype mice, while tumor growth is significantly suppressed accompanied by apoptosis of HCC cells in Isg15 -KO mice. Mechanistically, ISG15 promotes the activity of γ-glutamate cysteine ligase (γ-GCL), a rate-limiting heterodimeric holoenzyme of glutathione synthesis consisting of glutamate-cysteine ligase catalytic subunit (GCLC) and glutamate-cysteine ligase modifier subunit (GCLM). Independent of ISGylation, ISG15 forms an ISG15/GCLM/GCLC complex that promotes GCLM-GCLC interaction, increases glutathione generation and inhibits HFD-induced apoptosis in HCC cells. Together, an anti-apoptotic ISG15-γ-GCL-glutothione axis is suggested in HFD-promoted HCC.}, archive = {J_ADVS}, author = {Xinran Liu and Qiujin Ma and Zhao Jia and Yihao Zhou and Churong Zou and Yushuo Xiao and Yuchen Chen and Chuyao Ma and Liangliang Song and Jing Yang and Chen Wang and Huidie Xu and Hong Chen and Jiajian Shi and Junqiu Yue and Yu Sun and Desheng Hu and Robert B Petersen and Yangkai Li and Anlin Peng and Kun Huang and Ling Zheng}, doi = {10.1002/advs.202416401}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2416401}, shortjournal = {Adv. Sci.}, title = {ISG15 enhances the activity of γ-glutamate cysteine ligase to suppress apoptosis in high fat diet-promoted hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). RACK7 interacts with PRC2 complex to regulate astrocyte development. ADVS, 12(19), 2416350. (www)

  @article{ , abstract = {Dysregulation of epigenetic mechanisms plays a crucial role in brain development and disease. Emerging largely evidence suggests that Receptor for Activated C-kinase 7 (RACK7), an epigenetic reader protein, may play a role in brain development and neural developmental disease, but in vivo explorations are still lacking. Here, a Rack7 conditional knock-out mouse model is established and shows that Rack7 -deficient mice exhibit overt developmental defects associated with aberrant astrocyte development. Mechanistically, it is found that RACK7 interacts with the histone H3 lysine 27 (H3K27) methyltransferase, i.e., the Polycomb Repressive Complex 2 (PRC2) complex, to establish the genomic locations of Suppressor of Zeste 12 homolog (SUZ12) and H3K27 methylation. Deletion of Rack7 in astrocytes leads to a remarkable decrease of H3K27me3 chromatin localization genome-wide. Furthermore, RACK7 works together with H3K27me3 to prevent overactivation of the Wnt signaling pathway and other astrocyte differentiation genes are found. Collectively, this study provides new insights into the cellular and molecular mechanisms underlying brain development regulated by RACK7.}, archive = {J_ADVS}, author = {Fangfang Jiao and Tianxiang Tang and Bowen Wang and Shengfei He and Yue Zhang and Li Dong and Bo Xu and Ying Liu and Ping Zhu and Rui Guo}, doi = {10.1002/advs.202416350}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2416350}, shortjournal = {Adv. Sci.}, title = {RACK7 interacts with PRC2 complex to regulate astrocyte development}, volume = {12}, year = {2025}, }
• (2025). Identification and biological evaluation of a novel CLK4 inhibitor targeting alternative splicing in pancreatic cancer using structure-based virtual screening. ADVS, 12(19), 2416323. (www)

  @article{ , abstract = {Pancreatic cancer is an aggressive malignancy with a poor prognosis and limited treatment options. Cdc-like kinase 4 (CLK4), a kinase that regulates alternative splicing by phosphorylating spliceosome components, is implicated in aberrant splicing events driving pancreatic cancer progression. In this study, we established a computational model that integrates pharmacological interactions of CLK4 inhibitors with an improved hit rate. Through this model, we identified a novel CLK4 inhibitor, compound 150441, with a 50% inhibitory concentration (IC 50 ) value of 21.4 n m . Structure-activity relationship analysis was performed to investigate key interactions and functional groups. Kinase profiling revealed that compound 150441 is selective for CLK4. Subsequent in vitro assays demonstrated that this inhibitor effectively suppressed cell growth and viability of pancreatic cancer cells. In addition, it inhibited the phosphorylation of key splicing factors, including serine- and arginine-rich splicing factor (SRSF) 4 and SRSF6. Cell cycle analysis further indicated that the compound induced G2/M arrest, leading to apoptosis. RNA-seq analysis revealed that the compound induced significant changes in alternative splicing and key biological pathways, including RNA processing, DNA replication, DNA damage, and mitosis. These findings suggest that compound 150441 has promising potential for further development as a novel pancreatic cancer treatment.}, archive = {J_ADVS}, author = {Chun-Lin Yang and Yi-Wen Wu and Huang-Ju Tu and Yun-Hsuan Yeh and Tony Eight Lin and Tzu-Ying Sung and Mu-Chun Li and Shih-Chung Yen and Jui-Hua Hsieh and Ming-Chin Yu and Sen-Yung Hsieh and Hsing-Pang Hsieh and Shiow-Lin Pan and Kai-Cheng Hsu}, doi = {10.1002/advs.202416323}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2416323}, shortjournal = {Adv. Sci.}, title = {Identification and biological evaluation of a novel CLK4 inhibitor targeting alternative splicing in pancreatic cancer using structure-based virtual screening}, volume = {12}, year = {2025}, }
• (2025). Trifunctional sialylation-based SF-ZIF@NA hydrogel for selective osteoclast inhibition and enhanced bone-vessel regeneration in osteoporotic bone defects. ADVS, 12(19), 2415895. (www)

  @article{ , abstract = {Osteoporotic bone defects are challenging to repair due to imbalances in bone resorption and formation, coupled with insufficient vascularization. To address these issues, it develops a trifunctional hydrogel (SF-ZIF@NA) designed to selectively inhibit osteoclast activity and enhance vascularized bone regeneration. By enzymatically removing sialic acid, SF-ZIF@NA prevents precursor osteoclasts (pOCs) from fusing into bone-resorbing mature osteoclasts (mOCs), thereby preserving pOCs and their anabolic functions. Additionally, the hydrogel releases Zinc ion (Zn 2 ⁺) in response to acidic conditions, promoting osteogenesis and angiogenesis. In vitro results confirmed that SF-ZIF@NA impedes osteoclast fusion, enhances platelet-derived growth factor-BB (PDGF-BB secretion from pOCs, and activates the FAK (focal adhesion kinase) signaling pathway to stimulate vascularized bone formation. In osteoporotic bone defect models, SF-ZIF@NA accelerated bone repair with increased bone density and vascularization. These findings demonstrate that SF-ZIF@NA offers a targeted and multifunctional strategy for osteoporotic bone regeneration by concurrently modulating osteoclast activity and promoting angiogenesis.}, archive = {J_ADVS}, author = {Zhengrong Chen and Wenxin Yang and Yong Tang and Qianqian Dong and Kui Huang and Jiulin Tan and Jie Zhang and Juan Cai and Qixiu Yu and Qijie Dai and Jianzhong Xu and Shuquan Guo and Ce Dou and Fei Luo}, doi = {10.1002/advs.202415895}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2415895}, shortjournal = {Adv. Sci.}, title = {Trifunctional sialylation-based SF-ZIF@NA hydrogel for selective osteoclast inhibition and enhanced bone-vessel regeneration in osteoporotic bone defects}, volume = {12}, year = {2025}, }
• (2025). Tetrahedral nitrogen atoms arrangement in A-site cations: A new approach for regulating sensitivity and energy of perovskite energetic materials. ADVS, 12(19), 2415680. (www)

  @article{ , abstract = {Perovskite energetic materials (PEMs) are emerging combinations of oxidants and reductives, which are promising in explosives owing to the advantages of high energy, simple synthesis and low cost. However, the friction sensitivity of the currently reported PEMs is so high that it limits the further application of PEMs. In this work, a tetrahedral nitrogen-atom-arrangement structure, urotropine, is introduced as A-site cation of PEMs, then four urotropine-based PEMs ([C 6 H 14 N 4 ][M(ClO 4 ) 3 ], named TAPs) are successfully constructed experimentally for the first time. The crystal structure, reaction progress, thermal decomposition, sensitivity, and detonation performance of TAPs are characterized. The results indicate that, different from the existing cubic PEMs, the crystal structure of TAPs experiences compression along the c -axis, despite the c -axis length being twice that of the a or b -axes. As expected, the friction sensitivity is remarkably reduced and the detonation performance is significantly improved. Moreover, the hardness of A-site cations is proposed as a key factor affecting the impact sensitivity of PEMs, while C─H···O hydrogen bonds play an important role in regulating friction sensitivity. The emergence of TAPs provides a design concept of high-energy insensitive PEMs and a unique perspective for understanding the mechanical sensitivity of energetic materials.}, archive = {J_ADVS}, author = {Shiyong Chen and Yuan Gao and Cheng Dong and Lixiao Shen and Yinning Zeng and Peng Bao and Yan Li and Zhenxin Yi and Houhe Chen and Shunguan Zhu and Lin Zhang}, doi = {10.1002/advs.202415680}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2415680}, shortjournal = {Adv. Sci.}, title = {Tetrahedral nitrogen atoms arrangement in A-site cations: A new approach for regulating sensitivity and energy of perovskite energetic materials}, volume = {12}, year = {2025}, }
• (2025). Development of MDM2-targeting PROTAC for advancing bone regeneration. ADVS, 12(19), 2415626. (www)

  @article{ , abstract = {Proteolysis-targeting chimeras (PROTACs) degrade target proteins through the ubiquitin-proteasome system. To date, PROTACs are primarily used to treat various diseases; however, they have not been applied in regenerative therapy. Herein, this work introduces MDM2-targeting PROTACs customized for application in bone regeneration. An MDM2-PROTAC library is constructed by combining Nutlin-3 and CRBN ligands with various linker designs. Through a multistep validation process, this work develops MDM2-PROTACs (CL144 and CL174) that presented potent degradation efficiency and a robust inductive effect on the biomineralization. Next, this work performs whole-transcriptome analysis to dissect the biological effects of the CL144, and reveals the upregulation of osteogenic marker genes. Furthermore, CL144 effectively induced bone regeneration in bone graft and ovariectomy (OVX) models after local and systemic administration, respectively. In the OVX model, the combination treatment with CL144 and alendronate induced a synergistic effect. Overall, this study demonstrates the promising role of MDM2-PROTAC in promoting bone regeneration, marking the first step toward expanding the application of the PROTAC technology.}, archive = {J_ADVS}, author = {Sol Jeong and Jae-Kook Cha and Wasim Ahmed and Jaewan Kim and Minsup Kim and Kyung Tae Hong and Wonji Choi and Sunjoo Choi and Tae Hyeon Yoo and Hyun‑Ju An and Seung Chan An and Jaemin Lee and Jimin Choi and Sun-Young Kim and Jun-Seok Lee and Soonchul Lee and Junwon Choi and Jin Man Kim}, doi = {10.1002/advs.202415626}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2415626}, shortjournal = {Adv. Sci.}, title = {Development of MDM2-targeting PROTAC for advancing bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Silicon enhances functional mitochondrial transfer to improve neurovascularization in diabetic bone regeneration. ADVS, 12(19), 2415459. (www)

  @article{ , abstract = {Diabetes mellitus is a metabolic disorder associated with an increased risk of fractures and delayed fracture healing, leading to a higher prevalence of bone defects. Recent advancements in strategies aim at regulating immune responses and enhancing neurovascularization have not met expectations. This study demonstrates that a silicon-based strategy significantly enhances vascularization and innervation, thereby optimizing the repair of diabetic bone defects. Silicon improves mitochondrial function and modulates mitochondrial fission dynamics in macrophages via the Drp1-Mff signaling pathway. Subsequently, functional mitochondria are transferred from macrophages to endothelial and neuronal cells through microvesicles, providing a protective mechanism for blood vessels and peripheral nerves during early wound healing. On this basis, an optimized strategy combining a silicified collagen scaffold with a Drp1-Fis1 interaction inhibitor is used to further regulate mitochondrial fission in macrophages and enhance the trafficking of functional mitochondria into stressed receptor cells. In diabetic mice with critical-sized calvarial defects, the silicon-based treatment significantly promotes vessel formation, nerve growth, and mineralized tissue development. These findings provide therapeutic insights into the role of silicon in promoting diabetic bone regeneration and highlight the importance of intercellular communication in diabetic conditions.}, archive = {J_ADVS}, author = {Yu-Xuan Ma and Chen Lei and Tao Ye and Qian-Qian Wan and Kai-Yan Wang and Yi-Na Zhu and Ling Li and Xu-Fang Liu and Long-Zhang Niu and Franklin R. Tay and Zhao Mu and Kai Jiao and Li-Na Niu}, doi = {10.1002/advs.202415459}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2415459}, shortjournal = {Adv. Sci.}, title = {Silicon enhances functional mitochondrial transfer to improve neurovascularization in diabetic bone regeneration}, volume = {12}, year = {2025}, }
• (2025). RAB3B dictates mTORC1/S6 signaling in chordoma and predicts response to mTORC1-targeted therapy. ADVS, 12(19), 2415384. (www)

  @article{ , abstract = {Chordoma, a rare mesenchymal malignancy, exhibits a high tendency to postoperative recurrence and poor prognosis. To date, its tumorigenic regulatory mechanisms remain elusive, leading to a lack of effective therapeutic targets and drug sensitivity indicators. Here, via transcriptome and proteome analyses, RAB3B is unveiled as a prominent oncogenic regulator in chordoma, with high expression and enhancer-associated transcriptional activity. Notably, RAB3B ablation attenuated the chordoma cell stemness and malignant biological properties in vivo and in vitro. Through determining the RAB3B-mediated program in chordoma, it is identified that it enhanced the phosphorylation of S6 specifically at S235/236 and directly bound to S6. Mechanistically, RAB3B physically interacted with phosphorylase DUSP12, and blocked the DUSP12-mediated dephosphorylation of p-S6 (S235/236). Pharmacological targeting mTORC1 pathway dramatically impeded the RAB3B-induced stemness regulation, protein translation, and chordoma tumorigenicity, while RAB3B knockdown desensitized mTORC1 inhibition. In clinic, the combination of RAB3B and p-S6 suggested a good prognostic value and predicted mTORC1 inhibitors response for chordoma patients. Altogether, this work uncovers RAB3B/DUSP12 as the novel regulators of S6 phosphorylation (S235/236), and suggests the oncogenic and predictive roles of RAB3B/p-S6 in chordoma, indicating therapeutic potentials of mTORC1-targeted therapy for advanced chordoma patients with aberrant RAB3B/p-S6 hyperactivation.}, archive = {J_ADVS}, author = {Jianxuan Gao and Jiali Jin and Runzhi Huang and Siqiao Wang and Sihui Song and Yu Zhang and Yongai Li and Jun Lin and Zhengyan Chang and Zongqiang Huang and Wei Sun and Huabin Yin and Dianwen Song and Jianru Xiao and Ping Wang and Tong Meng}, doi = {10.1002/advs.202415384}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2415384}, shortjournal = {Adv. Sci.}, title = {RAB3B dictates mTORC1/S6 signaling in chordoma and predicts response to mTORC1-targeted therapy}, volume = {12}, year = {2025}, }
• (2025). Targeted DNA nanomachine enables specific miRNA-responsive singlet oxygen amplification for precise cutaneous squamous cancer therapy. ADVS, 12(19), 2415296. (www)

  @article{ , abstract = {Photodynamic therapy (PDT) is a promising strategy for the treatment of skin-related tumors including cutaneous squamous cells carcinoma (cSCC). However, it is hard to balance the dosage off-target phototoxicity while maintaining satisfactory therapeutic effect. In addition, oxygen-dependent photosensitizers (PSs) are affected by tumor hypoxic environment, which further causes inefficient photocatalysis and reduces therapeutic effect. Herein, an intelligent DNA nanomachine based on tetrahedral DNA framework is proposed, incorporated with tumor-targeted aptamer and specific miRNA-responsive hairpin DNA catalytic assembly (HCA), for precise and high-efficient therapy of cSCC. After aptamer-mediated targeted delivery, a cSCC-specific miRNA selected by tissue sequencing analysis is used to activateHCA, for amplifying PSs and controllably releasing chemotherapeutic drugs. Sequential recognition can greatly improve tumor-specific accumulation and high-dose activation. Moreover, hemin is incorporated into DNA to catalytically produce oxygen. In vitro and in vivo experiments demonstrated that this DNA nanomachine greatly improved anti-tumor effect and realized effective ablation of cSCC in mice, with barely systemic toxicity and inflammation. It is anticipated that this strategy will promote biomedical applications of tumor-specific miRNA and provide a promising option for the non-invasive treatment of skin-associated tumors.}, archive = {J_ADVS}, author = {Hanane Aliouat and Detian Zhang and Lanyuan Peng and Jiaxin Huang and Hongshi Cheng and Jiaojiao Zhu and Xiang Chen and Nuli Xie and Wenhu Zhou and Shuang Zhao}, doi = {10.1002/advs.202415296}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2415296}, shortjournal = {Adv. Sci.}, title = {Targeted DNA nanomachine enables specific miRNA-responsive singlet oxygen amplification for precise cutaneous squamous cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Laser ultrafast confined alloying of sub-5 nm RuM (M = cu, rh, and pd) particles on carbon nanotubes for hydrogen evolution reaction. ADVS, 12(19), 2415065. (www)

  @article{ , abstract = {Thermodynamic immiscibility is a challenge for intermetallic alloying of sub-5 nm Ru-based alloys, which are excellent electrochemical catalysts for water splitting. In this study, nanosecond laser ultrafast confined alloying (LUCA) is proposed to break the immiscible-to-miscible transition limit in the synthesis of carbon nanotubes (CNTs) supported sub-5 nm bimetallic RuM (M = Cu, Rh, and Pd) alloy nanoparticles (NPs). The alloying of non-noble metal Cu with varying atomic ratios of RuCu alloys is appealing owing to the low price of Cu and cost-effective synthesis for large-scale practical applications. Benefiting from the synergistic alloying effect and resultant H/OH binding energy alteration, the Ru 95 Cu 5 /CNTs catalysts display excellent electrocatalytic alkaline hydrogen evolution reaction (HER) activity with an overpotential of 17 mV and Tafel slope of 28.4 mV dec −1 at 10 mA cm −2 , and high robustness over long-term 5000 cyclic voltammetry cycles. The performance is much better than LUCA-synthesized CNTs-supported Ru 86 Rh 14 , Ru 89 Pd 11 , Ru, and Cu NPs catalysts, commercial benchmark 20% Pt/C, and other mainstream Ru-based catalysts including wet chemistry-synthesized RuRh particles (overpotential of 25 mV, Tafel slope of 47.5 mVdec −1 ) and RuCu/CNTs (overpotential of 39 mV) synthesized using the flash Joule heating method, indicating the great potential of LUCA for screening new classes of HER catalysts.}, archive = {J_ADVS}, author = {Taiping Hu and Dongshi Zhang and Ningning He and Shuxian Wei and Xingyu Kang and Wei Zhang and Yunyu Cai and Yixing Ye and Pengfei Li and Changhao Liang}, doi = {10.1002/advs.202415065}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2415065}, shortjournal = {Adv. Sci.}, title = {Laser ultrafast confined alloying of sub-5 nm RuM (M = cu, rh, and pd) particles on carbon nanotubes for hydrogen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). Vessel-on-A-chip coupled proteomics reveal pressure-overload-induced vascular remodeling. ADVS, 12(19), 2415024. (www)

  @article{ , abstract = {Hypertension, the leading cause of cardiovascular disease and premature mortality, is characterized by increased vessel stretch and alterations in vascular smooth muscle cells (VSMCs). In this study, a vessel-on-a-chip model is developed to simulate both physiological and pathological stretch conditions alongside a mouse model of hypertension. Proteomics analysis is applied to investigate changes in VSMCs using the vessel-on-a-chip system and compared these findings with data from the mouse model. The results demonstrates that physiological stretch enhances the expression of contractile markers in VSMCs. Additionally, the chip effectively replicates cellular responses to pathological stretch and stress, including the upregulation of ERK signaling, calcium ion transport pathway, integrin signaling pathway, endoplasmic reticulum stress, toll-like receptor activation, oxidative stress, and synthesis of sphingolipids and ceramides. These findings indicate that the vessel chip successfully mimics in vivo biological events associated with hypertension. The vessel-on-a-chip system holds promise for advancing the study of vessel-related diseases and facilitating the development of novel hypertension therapeutics.}, archive = {J_ADVS}, author = {Yanjun Liu and Jianxujie Zheng and Lingyan Zhong and Zengyu Wang and Dan Zhao and Hong Lin and Xiaoxue Zhang and Ke Meng and Xiaoxia Yang and Dongxue Zhang and Ling Lin and Liang Qiao}, doi = {10.1002/advs.202415024}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2415024}, shortjournal = {Adv. Sci.}, title = {Vessel-on-A-chip coupled proteomics reveal pressure-overload-induced vascular remodeling}, volume = {12}, year = {2025}, }
• (2025). Correction to “CircNOLC1 promotes colorectal cancer liver metastasis by interacting with AZGP1 and sponging miR-212-5p to regulate reprogramming of the oxidative pentose phosphate pathway”. ADVS, 12(19), 2414965. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202414965}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414965}, shortjournal = {Adv. Sci.}, title = {Correction to “CircNOLC1 promotes colorectal cancer liver metastasis by interacting with AZGP1 and sponging miR-212-5p to regulate reprogramming of the oxidative pentose phosphate pathway”}, volume = {12}, year = {2025}, }
• (2025). Syntaxin 17 translocation mediated mitophagy switching drives hyperglycemia-induced vascular injury. ADVS, 12(19), 2414960. (www)

  @article{ , abstract = {The risk of diabetic cardiovascular complications is closely linked to the length of hyperglycemia exposure. Mitophagy plays a significant role in vascular endothelial injury. However, the specific mechanisms by which mitophagy contributes to endothelial injury during sustained hyperglycemia remain unclear. In diabetic ApoE −/− mice and human umbilical vein endothelial cell (HUVEC) models, mitophagy is enhanced following short-term and long-term high-glucose exposure. Short-term high-glucose exposure promotes Parkin-mediated mitophagy and upregulates mitochondrial fission protein 1 (Fis1) expression, whereas long-term high-glucose exposure suppresses Parkin-mediated mitophagy and downregulates Fis1. With prolonged high-glucose exposure, Syntaxin 17 (STX17) translocates from the endoplasmic reticulum to the mitochondria, activating STX17-mediated mitophagy. Silencing STX17 alleviates mitochondrial degradation, decreases reactive oxygen species (ROS) levels, enhances endothelial nitric oxide synthase (eNOS) phosphorylation, and reduces apoptosis. Silencing Fis1 accelerates the switching to STX17-mediated mitophagy, worsening endothelial dysfunction, whereas Fis1 overexpression prevents this switching, reducing ROS and apoptosis and enhancing eNOS phosphorylation. In summary, these findings suggest that the switching from Parkin-mediated to STX17-mediated mitophagy drives vascular endothelial injury following long-term hyperglycemic exposure, providing valuable insights into therapeutic strategies for diabetic cardiovascular complications.}, archive = {J_ADVS}, author = {Anqi Luo and Rui Wang and Jingwen Gong and Shuting Wang and Chuan Yun and Zongcun Chen and Yanan Jiang and Xiaoquan Liu and Haofu Dai and Haochen Liu and Yunsi Zheng}, doi = {10.1002/advs.202414960}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414960}, shortjournal = {Adv. Sci.}, title = {Syntaxin 17 translocation mediated mitophagy switching drives hyperglycemia-induced vascular injury}, volume = {12}, year = {2025}, }
• (2025). ProteoSeeker: A feature-rich metagenomic analysis tool for accessible and comprehensive metagenomic exploration. ADVS, 12(19), 2414877. (www)

  @article{ , abstract = {The vast majority of microbial diversity remains unculturable, limiting access to novel biotechnological resources. Advances in metagenomics have expanded the understanding of microbial communities, yet targeted protein discovery remains challenging. This study introduces ProteoSeeker , a command-line tool for streamlined metagenomic protein identification and annotation. ProteoSeeker operates in two primary modes: i) Seek mode, which screens the proteins according to user-defined protein families, and ii) Taxonomy mode, which uncovers the taxonomy of the host organisms. By automating key steps, ProteoSeeker reduces computational complexity, enabling time-efficient and comprehensive metagenomic analysis for both specialized and nonspecialized users. The efficiency of ProteoSeeker to achieve targeted enzyme discovery is demonstrated by identifying extremophilic enzymes with desired biochemical features, such as amylases for starch hydrolysis and carbonic anhydrases for CO₂ capture applications. By democratizing functional metagenomics, ProteoSeeker is anticipated to accelerate biotechnology, synthetic biology, and biomedical research and innovation.}, archive = {J_ADVS}, author = {Georgios Filis and Dimitra Bezantakou and Konstantinos Rigkos and Despina Noti and Pavlos Saridis and Dimitra Zarafeta and Georgios Skretas}, doi = {10.1002/advs.202414877}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414877}, shortjournal = {Adv. Sci.}, title = {ProteoSeeker: A feature-rich metagenomic analysis tool for accessible and comprehensive metagenomic exploration}, volume = {12}, year = {2025}, }
• (2025). Photopatternable PEDOT:PSS hydrogels for high-resolution photolithography. ADVS, 12(19), 2414834. (www)

  @article{ , abstract = {Conducting polymer hydrogels have been extensively explored toward diverse applications like bioelectronics and soft robotics. However, the fabrication resolution of conducting polymer hydrogels by typical techniques, including ink-jet printing, 3D-printing, etc., has been generally limited to >10 µm, significantly restricting rapid innovations and broad applications of conducting polymer hydrogels. To address this issue, a photosensitive biphasic conducting polymer hydrogel (PB-CH) is rationally designed and synthesized, comprising poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) as the conductive phase and a light-sensitive matrix as the mechanical phase. The formation of phase-separated structures within PB-CH preserves the integrity of the conductive channels during the photoinitiated cross-linking. This minimizes the conductivity loss, a common limitation in similar materials. Remarkably, the resultant PB-CH exhibits a combination of excellent electrical conductivity (≈30 S cm −1 ), robust mechanical performance (tensile strain up to 50%), and high photopatternability. A detailed investigation of the photolithography process identifies key technological parameters that enable high-resolution patterning of 5 µm. By simultaneously maintaining processability, conductivity, and mechanical flexibility, this PB-CH represents an ideal candidate for advanced flexible electronic applications, offering a new technique to fabricating high-performance conducting polymer hydrogels.}, archive = {J_ADVS}, author = {Wen Wang and Jingcheng Liu and Hai Li and Yi Zhao and Rongtai Wan and Qiaobo Wang and Jingkun Xu and Baoyang Lu}, doi = {10.1002/advs.202414834}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414834}, shortjournal = {Adv. Sci.}, title = {Photopatternable PEDOT:PSS hydrogels for high-resolution photolithography}, volume = {12}, year = {2025}, }
• (2025). DNA–Protein binding is dominated by short anchoring elements. ADVS, 12(19), 2414823. (www)

  @article{ , abstract = {Unveiling the complexities of gene expression regulation, the study explores the intricate DNA-binding mechanisms of transcription factors (TFs). By employing the KaScape method previously developed to measure both bound and unbound populations at thermodynamic equilibrium, “anchoring elements” (AEs), 3–4 base pair sequences, are identified in Arabidopsis WRKY and human PU.1 TFs crucial for binding affinity. Building on the BEESEM method, the study introduces the AEEscape algorithm, which advances the AE concept by creating a precise model of the position-specific k-mer binding energy landscape. This method allows for the direct identification of the dominant role of AEs from experimental data. Moreover, when integrated with genomic data, it reveals an energetic funnel around transcription factor binding sites (TFBSs), which is directly correlated with the density of AEs (AED). The findings not only offer a fresh perspective on TF-TFBS interactions but also highlight the critical role of AED in gene regulation. These insights can pave the way for innovative strategies to manipulate gene expression.}, archive = {J_ADVS}, author = {Hong Chen and Yongping Xu and Hao Ge and Xiao-Dong Su}, doi = {10.1002/advs.202414823}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414823}, shortjournal = {Adv. Sci.}, title = {DNA–Protein binding is dominated by short anchoring elements}, volume = {12}, year = {2025}, }
• (2025). The latest advances in mechanically robust self-healing polyurea based on dynamic chemistry. ADVS, 12(19), 2414788. (www)

  @article{ , abstract = {Polyureas are widely used in many fields such as civil, industry, and defense due to their excellent performance and structural adjustable properties. The development of self-healing polyurea materials with high strength and toughness, key connotations of their advanced applications, is both fascinating and challenging because these properties are associated with conflicting structural features, making it difficult to optimize these contradictory properties in a single material. In this review, the relationship between polyurea structure and performance is discussed, and the design strategy of self-healing polyurea networks based on dynamic interactions that allow for balancing high mechanical performance and repairability is delineated from a molecular design point of view. Lastly, a summary of the potential applications of polyurea in the fields of sensing, protective coatings, and recycling, as well as possible future challenges, is presented.}, archive = {J_ADVS}, author = {Yujia Hao and Guangming Zhu}, doi = {10.1002/advs.202414788}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414788}, shortjournal = {Adv. Sci.}, title = {The latest advances in mechanically robust self-healing polyurea based on dynamic chemistry}, volume = {12}, year = {2025}, }
• (2025). Direct quantification of Protein–Protein interactions in living bacterial cells. ADVS, 12(19), 2414777. (www)

  @article{ , abstract = {Quantitative measurement of protein–protein interactions (PPIs) within living cells is vital for understanding their cellular functions at the molecular level and for applications in synthetic biology, protein engineering, and drug discovery. Although several techniques have been developed to measure PPI strength in vitro, direct measurement of PPI strength within living bacterial cells remains challenging. Here, a method for quantitatively measuring PPIs by determining the dissociation constant ( K d ) in living E. coli using fluorescence resonance energy transfer (FRET), a technique termed KD-FRET, is reported. It is found that the direct excitation of the acceptor fluorophore among spectral crosstalks primarily results in non-interacting pairs exhibiting an apparent K d , leading to false-positive signals. KD-FRET proves highly effective in quantifying various PPI K d values, including both heterologous and homologous pairs. Moreover, KD-FRET enables the quantification of K d for interaction pairs that are unmeasurable in vitro owing to their instability under standard buffer conditions. KD-FRET is successfully applied in the development of a novel synthetic biology tool to enhance naringenin production in E. coli and lycopene production in S. cerevisiae by precisely engineering metabolic pathway. These results demonstrate the potential of KD-FRET as a powerful tool for studying PPIs in their native cellular environments.}, archive = {J_ADVS}, author = {Soojung Yi and Eunji Kim and Sora Yang and Gyeongmin Kim and Da-Woon Bae and Se-Young Son and Bo-Gyeong Jeong and Jeong Seok Ji and Hyung Ho Lee and Ji-Sook Hahn and Sun-Shin Cha and Yeo Joon Yoon and Nam Ki Lee}, doi = {10.1002/advs.202414777}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414777}, shortjournal = {Adv. Sci.}, title = {Direct quantification of Protein–Protein interactions in living bacterial cells}, volume = {12}, year = {2025}, }
• (2025). Engineering the immune response to biomaterials. ADVS, 12(19), 2414724. (www)

  @article{ , abstract = {Biomaterials are increasingly used as implants in the body, but they often elicit tissue reactions due to the immune system recognizing them as foreign bodies. These reactions typically involve the activation of innate immunity and the initiation of an inflammatory response, which can persist as chronic inflammation, causing implant failure. To reduce these risks, various strategies have been developed to modify the material composition, surface characteristics, or mechanical properties of biomaterials. Moreover, bioactive materials have emerged as a new class of biomaterials that can induce desirable tissue responses and form a strong bond between the implant and the host tissue. In recent years, different immunomodulatory strategies have been incorporated into biomaterials as drug delivery systems. Furthermore, more advanced molecule and cell-based immunomodulators have been developed and integrated with biomaterials. These emerging strategies will enable better control of the immune response to biomaterials and improve the function and longevity of implants and, ultimately, the outcome of biomaterial-based therapies.}, archive = {J_ADVS}, author = {Abolfazl Salehi Moghaddam and Mehran Bahrami and Einollah Sarikhani and Rumeysa Tutar and Yavuz Nuri Ertas and Faleh Tamimi and Ali Hedayatnia and Clotilde Jugie and Houman Savoji and Asma Talib Qureshi and Muhammad Rizwan and Chima V. Maduka and Nureddin Ashammakhi}, doi = {10.1002/advs.202414724}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414724}, shortjournal = {Adv. Sci.}, title = {Engineering the immune response to biomaterials}, volume = {12}, year = {2025}, }
• (2025). Pupylation-based proximity labeling unravels a comprehensive protein and phosphoprotein interactome of the arabidopsis TOR complex. ADVS, 12(19), 2414496. (www)

  @article{ , abstract = {Target of rapamycin (TOR) is a signaling hub that integrates developmental, hormonal, and environmental signals to optimize carbon allocation and plant growth. In plant cells, TOR acts together with the proteins LST8-1 and RAPTOR1 to form a core TOR complex (TORC). While these proteins comprise a functional TORC, they engage with many other proteins to ensure precise signal outputs. Although TORC interactions have attracted significant attention in the recent past, large parts of the interactome are still unknown. In this resource study, PUP-IT is adapted, a fully endogenously expressed protein proximity labeling toolbox, to map TORC protein–protein interactions using the core set of TORC as baits. It is outlined how this interactome is differentially phosphorylated during changes in carbon availability, uncovering putative direct TOR kinase targets. An AlphaFold-Multimer approach is further used to validate many interactors, thus outlining a comprehensive TORC interactome that includes over a hundred new candidate interactors and provides an invaluable resource to the plant cell signaling community.}, archive = {J_ADVS}, author = {Shuai Zheng and Leonard Blaschek and Delphine Pottier and Luuk Robin Hoegen Dijkhof and Beyza Özmen and Peng Ken Lim and Qiao Wen Tan and Marek Mutwil and Alexander Sebastian Hauser and Staffan Persson}, doi = {10.1002/advs.202414496}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414496}, shortjournal = {Adv. Sci.}, title = {Pupylation-based proximity labeling unravels a comprehensive protein and phosphoprotein interactome of the arabidopsis TOR complex}, volume = {12}, year = {2025}, }
• (2025). Cyclo-n9−: A novel 5/6 fused polynitrogen anion for high energy density materials. ADVS, 12(19), 2414394. (www)

  @article{ , abstract = {After cyclo -pentazolate anion, a 5/6 fused structure of N 9 − is constructed, and four novel nitrogen-rich ionic compounds are assembled on its basis. The results of the quantum calculations revealed an uneven distribution of electrons on cyclo -N 9 − , with significant charge density near the N5/N9 atoms and an ADCH charge of −0.425. The relative strength of chemical bonds is assessed through bond order analysis, which is further supplemented by transition state theory and ab initio molecular dynamics, ultimately leading to the identification of the decomposition pathways of cyclo -N 9 − . The aromaticity of cyclo -N 9 − and its individual sub-rings is cleverly validated through a combination of NICS_ZZ and ICSS methods. Among the eight systems, cyclo -N 9 − forms hydrogen bonds with other cations, and IGMH analysis revealed significant LP-π and π–π stacking interactions between [N 7 H 4 + ] and cyclo -N 9 − , both of which enhance system stability. The theoretical energy densities in all systems are at the forefront in the currently emerging nitrogen-rich compounds. Attributed to its extraordinarily high enthalpy of formation, the detonation performance of [N 7 H 4 + ] [N 9 − ] is particularly excellent. However, [NH 3 OH + ] [N 9 − ] exhibits better stability and most exciting performance, making it a highly promising candidate with application potential.}, archive = {J_ADVS}, author = {Xiaofeng Yuan and Ze Xu and Haolin Gu and Tongwei Zhang and Yuangang Xu and Ming Lu}, doi = {10.1002/advs.202414394}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414394}, shortjournal = {Adv. Sci.}, title = {Cyclo-n9−: A novel 5/6 fused polynitrogen anion for high energy density materials}, volume = {12}, year = {2025}, }
• (2025). Cation-anchoring-induced efficient n-type thermo-electric ionogel with ultra-high thermopower. ADVS, 12(19), 2414389. (www)

  @article{ , abstract = {Ionogels have emerged as promising candidates for low-grade thermal energy harvesting due to their leak-free electrolytes, exceptional flexibility, thermal stability, and high thermopower. While substantial progress in the thermoelectric performance of p-type ionogels, research on n-type ionic materials lags behind. Striking a harmonious balance between high mechanical performance and thermoelectric properties remains a formidable challenge. This work presents an advanced n-type ionogel system integrating polyethylene glycol diacrylate (PEGDA), hydroxyethyl methacrylate (HEMA), 1-allyl-3-methylimidazolium chloride ([AMIM]Cl), and bacterial cellulose (BC) through a rational design strategy. The synergistic combination of photo-polymerization and hydrogen-bonding networks effectively immobilizes imidazolium cations while enabling rapid chloride ion transport, creating a pronounced cation-anion mobility disparity that yields a substantial negative ionic Seebeck coefficient of −7.16 mV K⁻¹. Furthermore, BC's abundant hydroxyl groups establish multivalent hydrogen bonds within the ternary polymer matrix, endowing the composite with exceptional mechanical properties—notably a tensile strength of 3.2 MPa and toughness of 4.1 MJ m⁻ 3 . Moreover, the ionogel exhibits sensitive responses to stimuli such as pressure, strain, and temperature. The thermoelectric modules fabricated can harness body heat to illuminate a bulb, showcasing great potential for low-grade energy harvesting and ultra-sensitive sensing.}, archive = {J_ADVS}, author = {Wenchao Zhen and Chengshuai Lu and Duo Li and Guangfan Meng and Hongqin Wang and Yifei Jiang and Jiang Lou and Wenjia Han}, doi = {10.1002/advs.202414389}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2414389}, shortjournal = {Adv. Sci.}, title = {Cation-anchoring-induced efficient n-type thermo-electric ionogel with ultra-high thermopower}, volume = {12}, year = {2025}, }
• (2025). Role of testosterone signaling in microglia: A potential role for sex-related differences in alzheimer's disease. ADVS, 12(19), 2413375. (www)

  @article{ , abstract = {Alzheimer's disease (AD) is less prevalent in men than in women, although mechanisms remain unclear. Microglia degrade aggregated amyloid β (Aβ) through the lysosomal system, including autophagy. G protein-coupled receptor family C group 6 member A (GPRC6A), predominantly expressed in mouse microglial MG6 cells, is a primary mediator of testosterone signaling. This study examines testosterone's role in modulating Aβ-induced autophagy in microglia. Testosterone promotes Aβ-induced autophagy leading to Aβ clearance in MG6 cells by suppressing extracellular signal-regulated kinase (ERK) phosphorylation and subsequently inhibiting mammalian target of rapamycin (mTOR) activation, which is abrogated by shRNA knockdown of GPRC6A. In in vivo experiments with male 5xFAD AD model mice, Aβ clearance activity is associated with autophagy in microglia and is reduced by orchiectomy, but restored by testosterone supplementation. ERK phosphorylation in the brains of male AD model mice is upregulated by orchiectomy. Therefore, testosterone is involved in autophagy-mediated Aβ clearance in microglia. Aβ accumulation in human brain samples from patients with AD is significantly lower in men than in women, with less pronounced colocalization of Aβ with p62 aggregates, suggesting enhanced autophagic activity in men. In conclusion, testosterone enhances Aβ-induced autophagy in microglia, possibly contributing to lower susceptibility to AD in men.}, archive = {J_ADVS}, author = {Haiyan Du and Akiko Mizokami and Junjun Ni and Simeng Zhang and Yosuke Yamawaki and Tomomi Sano and Eijiro Jimi and Isei Tanida and Takashi Kanematsu}, doi = {10.1002/advs.202413375}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2413375}, shortjournal = {Adv. Sci.}, title = {Role of testosterone signaling in microglia: A potential role for sex-related differences in alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Bioinspired strong and tough layered bulk composites via mycelial interface anchoring strategy. ADVS, 12(19), 2413226. (www)

  @article{ , abstract = {Lightweight structural composite materials are widely used in automobiles, aerospace, and other fields. However, achieving the integration of structural and functional properties, such as the ability to monitor external forces, remains a significant challenge. Nacre and turtle shells in nature are strong and tough due to their unique ordered structure of alternating soft and hard phases. Inspired by this, an interface anchoring strategy is proposed which leverages hyphae (filamentous structure forming the vegetative part of fungi) to fix the hard-phase graphene nanosheets (GNs) and the soft-phase intertwined polymer matrix to form theree-dimentional (3D) layered bulk composites (LBCs). The growth pattern of fungi is utilized to place GNs and assemble polyethylene glycol-polyvinyl alcohol (PEG-PVA) to fabricate the LBCs, which is different from most existing preparation methods of bulk biomimetic composites. The LBCs exhibit self-regenerative capabilities and are amenable to scalable manufacturing. These composites demonstrate impressive mechanical properties, including a specific strength of 92.8 MPa g cm −3 , fracture toughness of 6.5 MPa m −1/2 , and impact resistance of ∼3.1 kJ m −2 , outperforming both natural nacre and other biomimetic layered composites. Furthermore, the LBCs display effective protective warning functions under external force stimulations, making them a promising material for anti-collision applications in industries such as sports and aerospace.}, archive = {J_ADVS}, author = {Hao Wang and Jurui Liu and Zhangyu Wu and Xianfeng Chen and Kai Jin and Jie Tao and Bin Wang}, doi = {10.1002/advs.202413226}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2413226}, shortjournal = {Adv. Sci.}, title = {Bioinspired strong and tough layered bulk composites via mycelial interface anchoring strategy}, volume = {12}, year = {2025}, }
• (2025). Simultaneous monitoring of tyrosinase and ATP in thick brain tissues using a single two-photon fluorescent probe. ADVS, 12(19), 2413220. (www)

  @article{ , abstract = {Cellular redox homeostasis and energy metabolism in the central nervous system are associated with neurodegenerative diseases. However, their real-time and concurrent monitoring in thick tissues remains challenging. Herein, a single dual-emission two-photon fluorescent probe (named DST ) is designed for the simultaneous tracking of tyrosinase (TYR) and adenosine triphosphate (ATP), thereby enabling the real-time monitoring of both neurocellular redox homeostasis and energy metabolism in brain tissue. The developed DST probe exhibits excellent sensitivity and selectivity toward TYR and ATP, with distinctive responses in the blue and red fluorescence channels being observed without spectra crosstalk. Using this probe, the correlation and regulatory mechanism between TYR and ATP during oxidative stress are uncovered. Additionally, the two-photon nature of this probe allows alterations in the TYR and ATP levels to be monitored across different brain regions in an Alzheimer's disease (AD) mouse model. Notably, a significant decrease in ATP levels is revealed within the somatosensory cortex (S1BF) and caudate putamen brain regions of an AD mouse, alongside an increase in TYR levels within the S1BF and laterodorsal thalamic nucleus brain regions. These findings indicate the potential of applying the spatially resolved regulation of neurocellular redox homeostasis and energy metabolism to treat neurodegenerative diseases.}, archive = {J_ADVS}, author = {Hong Huang and Huiru Li and Yong Zhang and Xuhan Xia and Ningwen Zhang and Haixin Fan and Longhua Guo and Yongyong Cao and Hu Pan and Ruijie Deng and Yangang Wang and Rodrigo Ledesma-Amaro and Jianguo Xu}, doi = {10.1002/advs.202413220}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2413220}, shortjournal = {Adv. Sci.}, title = {Simultaneous monitoring of tyrosinase and ATP in thick brain tissues using a single two-photon fluorescent probe}, volume = {12}, year = {2025}, }
• (2025). The rise of chalcohalide solar cells: Comprehensive insights from materials to devices. ADVS, 12(19), 2413131. (www)

  @article{ , abstract = {While lead-halide perovskites achieve high efficiencies, their toxicity and instability drive the search for safer materials. Chalcohalides, combining chalcogen and halogen anions in versatile structures, emerge as earth-abundant, nontoxic alternatives for efficient photovoltaic (PV) devices. A wide variety of chalcohalide materials, including pnictogen metals-, post-transition metals-, mixed-metals- and organic–inorganic metals-based chalcohalides, offer diverse structural, compositional, and optoelectronic characteristics. Some of these materials have already been experimentally synthesized and integrated into PV devices, achieving efficiencies of 4–6%, while others remain theoretically predicated. Despite these advancements, significant challenges must be addressed to fully realize the potential of chalcohalides as next-generation PV absorbers. This review provides a comprehensive insight of the fundamental properties of chalcohalide materials, emphasizing their unique structures, highly interesting optoelectronic and dielectric properties, to fuel further research and guide the development of high-efficiency chalcohalide solar cells. Various synthesis techniques are discussed, highlighting important and potentially overlooked strategies for fabricating complex quaternary and pentanary chalcohalide materials. Additionally, the working principles of different device structures and recent advances in fabricating efficient chalcohalide solar cells are covered. We hope that this review inspires further exciting research, innovative approaches, and breakthroughs in the field of chalcohalide materials.}, archive = {J_ADVS}, author = {Hongrui Zhang and Yiming Xia and Yangfan Zhang and Uma V. Ghorpade and Mingrui He and Seung Wook Shin and Xiaojing Hao and Mahesh P. Suryawanshi}, doi = {10.1002/advs.202413131}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2413131}, shortjournal = {Adv. Sci.}, title = {The rise of chalcohalide solar cells: Comprehensive insights from materials to devices}, volume = {12}, year = {2025}, }
• (2025). Correction to “Biomimetic liposomal nanoplatinum for targeted cancer chemophototherapy”. ADVS, 12(19), 2412806. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202412806}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2412806}, shortjournal = {Adv. Sci.}, title = {Correction to “Biomimetic liposomal nanoplatinum for targeted cancer chemophototherapy”}, volume = {12}, year = {2025}, }
• (2025). Resilient membranized coacervates formed through spontaneous wrapping of heat-destabilized lipid bilayers around coacervate droplets. ADVS, 12(19), 2412312. (www)

  @article{ , abstract = {Membranes and the membraneless biocondensates help organize cells and work synergistically to drive cellular processes. Separately, membrane-bound and membraneless compartments face difficulties as stable protocells or synthetic cell systems. Here, we present a new method to create membranized coacervates (MCs) for coacervates with any surface charge and a wide range of phospholipid membrane compositions. MCs are formed when liposomes, destabilized using heat and divalent ions, are mixed with coacervate dispersions. Unlike previous reports of hybrid coacervates surrounded by membranes, the MC membranes form an effective barrier also against small molecules, including calcein and TAMRA. The MC membranes provide excellent stability to the protocells at pH 2–10, salt concentrations of up to 0.5 м, hypotonic and hypertonic conditions, and repeated freeze-thaw cycles. MCs performed better in all the tested conditions than both coacervates and liposomes. We attribute this behavior to the increased stability that coacervates and liposomes confer to each other when together. MC membranes are unilamellar and fluid, allowing lateral lipid diffusion, and the lipids are more densely packed compared to their corresponding liposomes. MCs can help us understand how stable primitive cells might have emerged and build advanced synthetic cells with enhanced stability and selectivity.}, archive = {J_ADVS}, author = {Sadaf Javed and Evan Spruijt}, doi = {10.1002/advs.202412312}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2412312}, shortjournal = {Adv. Sci.}, title = {Resilient membranized coacervates formed through spontaneous wrapping of heat-destabilized lipid bilayers around coacervate droplets}, volume = {12}, year = {2025}, }
• (2025). The novel dual GIP and GLP-1 receptor agonist tirzepatide attenuates colon cancer development by regulating glucose metabolism. ADVS, 12(19), 2411980. (www)

  @article{ , abstract = {Colorectal cancer (CRC) is a leading cause of cancer mortality while diabetes is a recognized risk factor for CRC. Here we report that tirzepatide (TZP), a novel polypeptide/glucagon-like peptide 1 receptor (GIPR/GLP-1R) agonist for the treatment of diabetes, has a role in attenuating CRC growth. TZP significantly inhibited colon cancer cell proliferation promoted apoptosis in vitro and induced durable tumor regression in vivo under hyperglycemic and nonhyperglycemic conditions across multiple murine cancer models. As glucose metabolism is known to critically regulate colon cancer progression, spatial metabolomics results revealed that glucose metabolites are robustly reduced in the colon cancer regions of the TZP-treated mice. TZP inhibited glucose uptake and destabilized hypoxia-inducible factor-1 alpha (HIF-1α) with reduced expression and activity of the rate-limiting enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) and phosphofructokinase 1 (PFK-1). These effects contributed to the downregulation of glycolysis and the tricarboxylic acid (TCA) cycle. TZP also delayed tumor development in a patient-derived xenograft (PDX) mouse model accompanied by HIF-1α mediated PFKFB3-PFK-1 inhibition. Therefore, the study provides strong evidence that glycolysis-blocking TZP, besides its application in treating type 2 diabetes, has the potential for preclinical studies as a therapy for colorectal cancer used either as monotherapy or in combination with other anticancer therapies.}, archive = {J_ADVS}, author = {Yikai Zhang and Yi Xie and Shenglong Xia and Xinnuo Ge and Jiaying Li and Fang Liu and Fan Jia and Shengyao Wang and Qiao Zhou and Menghan Gao and Weihuan Fang and Chao Zheng}, doi = {10.1002/advs.202411980}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2411980}, shortjournal = {Adv. Sci.}, title = {The novel dual GIP and GLP-1 receptor agonist tirzepatide attenuates colon cancer development by regulating glucose metabolism}, volume = {12}, year = {2025}, }
• (2025). Cost-effective identification of hepatocellular carcinoma from cirrhosis or chronic hepatitis virus infection using eight methylated plasma DNA markers. ADVS, 12(19), 2411945. (www)

  @article{ , abstract = {Early detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC) and/or hepatitis virus B/C infection (HVI) improves survival, highlighting the need for accurate, affordable diagnostic tools. Here, 11 methylated DNA markers (MDMs) are identified during marker discovery. In phase I, each selected MDM is validated in 175 plasma samples (HCC, n = 85; LC/HVI, n = 72) by the CO-methylation aMplification rEal-Time PCR (COMET) assay. Of these, 8 MDMs are qualified for phase II study, where a logistic regression model (COMET-LR) is trained and validated with 336 plasma samples (HCC, n = 211; LC/HVI, n = 113; training vs validation, 2:1). In the validation, the COMET-LR achieved 90.0% sensitivity at 97.4% specificity. Notably, sensitivity in patients with TNM stage I, diameter<3 cm, AFP-negative (<20 ng mL −1 ), PIVKA-II-negative (<40 mAU mL −1 ) is 82.4%, 77.8%, 88.6%, and 85.7%, respectively. The COMET-LR outperformed multiple protein markers (AFP, AFP-L3, and PIVKA-II) and published scores for HCC screening (GALAD, Doylestown, and ASAP), in terms of both sensitivity and specificity. The assay represents a significant advancement in addressing the unmet need for accurate, non-invasive, accessible, and cost-effective early detection tools for LC/HVI individuals. Further validation in a prospective cohort is warranted.}, archive = {J_ADVS}, author = {Tian Yang and Mingda Wang and Nanya Wang and Mingxin Pan and Yu Xu and Qiancheng You and Lanqing Yao and Jiahao Xu and Lihui Gu and Xiaodong Sun and Lei Zhang and Jiayue Xu and Bingsi Li and Guoqiang Wang and Shangli Cai and Guoyue Lv and Feng Shen}, doi = {10.1002/advs.202411945}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2411945}, shortjournal = {Adv. Sci.}, title = {Cost-effective identification of hepatocellular carcinoma from cirrhosis or chronic hepatitis virus infection using eight methylated plasma DNA markers}, volume = {12}, year = {2025}, }
• (2025). Simultaneous detection of neural activity and temperature in photothermal neural stimulation. ADVS, 12(19), 2411725. (www)

  @article{ , abstract = {Photothermal neuromodulation is a promising non-electrical neural stimulation technology for treating brain diseases through optically induced cell membrane temperature changes. However, the technology faces limitations in understanding its mechanism and impact on cellular behavior due to the restriction of directly measuring temperature changes at the cell interface from a very close distance during optical stimulation of neural cells, necessitating advancements in high-precision temperature sensing and electrical recording without light interference. This challenge is addressed by developing ultrasensitive cell membrane interface temperature sensors integrated with low-noise electrical recording capabilities. Transparent resistive temperature detectors, composed of a 10 nm thickness of ultrathin Au film fabricated by polyelectrolyte seed layer-induced thermal evaporation, achieved precise measurement and control of temperature changes without significant light interference and self-heating. A transparent electrode composed of the same ultrathin Au layer shows low-noise electrical recordings of neural signals upon photothermal stimulation. Using this multifunctional system, it is demonstrated that an average increase of 2.34 °C at neuronal cell surfaces results in over 95% suppression of hippocampal neural spike activities. The approach provides unprecedented insights into the mechanisms of photothermal neuromodulation and its effects on cellular behavior, paving the way for advanced treatments of neurological disorders.}, archive = {J_ADVS}, author = {Duhee Kim and Jee Woong Lee and Seoyoung Kang and Woongki Hong and Jungha Lee and Hyuk-Jun Kwon and Jae Eun Jang and Luke P. Lee and Hongki Kang}, doi = {10.1002/advs.202411725}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2411725}, shortjournal = {Adv. Sci.}, title = {Simultaneous detection of neural activity and temperature in photothermal neural stimulation}, volume = {12}, year = {2025}, }
• (2025). Artificial cornea substitute based on hydrogel skeletons with natural stromal hierarchical structure and extracellular matrix for sutureless transplantation. ADVS, 12(19), 2411540. (www)

  @article{ , abstract = {Corneal substitutes with structural and compositional characteristics resembling those of natural corneas have attracted considerable attention. However, biomimicking the complex hierarchical organization of corneal stroma is challenging. In this study, humanized corneal stroma-like adhesive patches (HCSPs) are prepared through a multi-step process. First, polyethylene glycol diacrylate is cast and cured within decellularized porcine cornea (DPC) templates. The DPCs are then enzymatically digested to obtain hydrogel skeletons, which are finally integrated with human corneal extracellular matrix and methacrylate gelatin. HCSPs replicate the ultrastructure, protein components, and optical properties of human corneas and exhibit improved anti-swelling and anti-degradation capabilities compared with conventional DPCs and recombinant human collagen patches. HCSPs can deliver methacrylate gelatin at the ocular surface temperature (37 °C) and achieve stable adhesion to the corneal stroma upon 405 nm light irradiation. Furthermore, HCSPs promote the survival and migration of corneal epithelial and stromal cells while preserving their phenotypes. In rabbit models of lamellar keratoplasty and microperforation repair, HCSPs accelerate epithelial healing, minimize suture-associated complications, and maintain structural stability. These findings suggest that HCSPs are promising donor corneal substitutes for clinical applications.}, archive = {J_ADVS}, author = {Long Zhao and Zhen Shi and Xiaoyu Zhang and Jingting Wang and Shang Yang and Fuyan Wang and Tan Li and Qingjun Zhou and Ting Wang and Weiyun Shi}, doi = {10.1002/advs.202411540}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2411540}, shortjournal = {Adv. Sci.}, title = {Artificial cornea substitute based on hydrogel skeletons with natural stromal hierarchical structure and extracellular matrix for sutureless transplantation}, volume = {12}, year = {2025}, }
• (2025). PRMT1 ablation in endothelial cells causes endothelial dysfunction and aggravates COPD attributable to dysregulated NF-κB signaling. ADVS, 12(19), 2411514. (www)

  @article{ , abstract = {Endothelial dysfunction and senescence are pivotal in pulmonary diseases, including chronic obstructive pulmonary disease (COPD). Protein arginine methyltransferase 1 (PRMT1) is the major enzyme responsible for asymmetric arginine dimethylation and plays a role in diverse biological processes, including cardiovascular function. Yet, its role in endothelial cells (ECs) remains poorly understood. Here, the role of PRMT1 is investigated in ECs, particularly in the context of COPD pathogenesis. Endothelial-specific PRMT1 knockout mice exhibit pulmonary hemorrhage, inflammation, barrier disruption, and apoptosis, accompanied by hyperactivation of nuclear factor kappa B (NF-κB). Bulk RNA sequencing of whole lungs and single-cell RNA sequencing of pulmonary ECs reveal that endothelial PRMT1 ablation results in a major alteration in inflammation-related gene expression. In a COPD model, PRMT1 deficiency aggravates the COPD phenotypes, including enlarged alveolar spaces, increased cell death, and senescence. PRMT1 inhibition in ECs exacerbates tumor necrosis factor alpha-triggered EC senescence and dysfunction attributable to NF-κB hyperactivation. PRMT1 as a critical regulator of pulmonary EC function, preventing NF-κB-driven endothelial dysfunction and senescence is highlighted here.}, archive = {J_ADVS}, author = {Thi Thuy Vy Tran and Yideul Jeong and Suwoo Kim and Ji Eun Yeom and Jinwoo Lee and Wonhwa Lee and Gyu-Un Bae and Jong-Sun Kang}, doi = {10.1002/advs.202411514}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2411514}, shortjournal = {Adv. Sci.}, title = {PRMT1 ablation in endothelial cells causes endothelial dysfunction and aggravates COPD attributable to dysregulated NF-κB signaling}, volume = {12}, year = {2025}, }
• (2025). Chemotherapy-mediated induction of PD-l1 via SEI1 facilitates myeloma immune evasion. ADVS, 12(19), 2411082. (www)

  @article{ , abstract = {Multiple myeloma (MM) is a plasma cell-derived malignancy. While immune checkpoint blockade immunotherapy has advanced myeloma treatment, chemotherapy remains the primary therapy. How chemotherapy interacts with immune checkpoint expression and impacts immunotherapy efficacy remains unclear. Here it is discovered that chemotherapeutic drugs induce DNA damage and activate the cyclic guanosine monophosphate (GMP)–adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway. This activation promotes phosphorylation of the interferon regulatory factor 7 (IRF7), which binds to the promoter region of SERTA-containing domain 1 ( SERTAD1 , also called SEI1 ) gene to enhance its transcription. The SEI1 directly interacts with the enhancer factors CREB-binding protein (CBP)/p300 and RNA polymerase II (pol II)-associated factor 1 (PAF1) complex, promoting transcriptional activity and leading to upregulation of programmed death ligand-1 (PD-L1) and immune escape in myeloma. Both in vitro and in vivo experiments demonstrate that treating myeloma cells with PD-L1 antibodies post-chemotherapy significantly enhances the killing efficiency of activated T cells, compared to sequential treatment with chemotherapy and PD-L1 antibodies. This research not only uncovers a pivotal regulatory mechanism of PD-L1 upregulation but also provides a compelling rationale for the integration of chemotherapy and immunotherapy in myeloma treatment.}, archive = {J_ADVS}, author = {Rui Chen and Zongwei Li and Zhihong Fang and Zou Li and Daoyan Yang and Yuan Li and Shurong Liu and Zhiqiang Liu and Rui Liu and Huan Liu}, doi = {10.1002/advs.202411082}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2411082}, shortjournal = {Adv. Sci.}, title = {Chemotherapy-mediated induction of PD-l1 via SEI1 facilitates myeloma immune evasion}, volume = {12}, year = {2025}, }
• (2025). Deciphering auditory hyperexcitability in otogl mutant mice unravels an auditory neuropathy mechanism. ADVS, 12(19), 2410776. (www)

  @article{ , abstract = {Auditory neuropathies affect the spiral ganglion neurons of the auditory nerve or their synapses with the sensory hair cells, distorting the sound information transmitted from the ear to the brain. Deciphering the underlying pathophysiological mechanisms remains challenging owing to the diversity of spiral ganglion neuron subtypes and associated central auditory circuits. An auditory neuropathy mechanism is unraveled by investigating the origin of auditory hyperexcitability in a mouse model for hereditary congenital deafness. Otogl encodes the large Otogelin-like protein, which is related to secreted epithelial mucins and is implicated in the mechanical stimulation of cochlear outer hair cells. Heterozygous Otogl +/− mutant mice display auditory hyperexcitability, highlighted by their susceptibility to audiogenic seizures induced by loud sounds. It is shown that Otogl is transiently expressed in a subpopulation of spiral ganglion neurons during cochlear development. Despite their apparently normal hearing, Otogl +/− mice display poor activation of the spiral ganglion neurons processing loud sounds and an elevation of the activation threshold of the middle the ear muscle reflex that attenuates loud sounds. The findings reveal how a neuropathy affecting spiral ganglion neurons specialized in loud sound processing and associated with the middle the ear muscle reflex can manifest itself as auditory hyperexcitability.}, archive = {J_ADVS}, author = {Mathilde Gagliardini and Sabrina Mechaussier and Carolina Campos Pina and Monica Morais and Olivier Postal and Philippe Jean and Typhaine Dupont and Amrit Singh-Estivalet and Shéhanie Udugampolage and Cyril Scandola and Elisabeth Verpy and Baptiste Libé-Philippot and Talya C. Inbar and Joanna Schwenkgrub and Carla Maria Barbosa Spinola and Raphaël Etournay and Aziz El-Amraoui and Brice Bathellier and Adeline Mallet and Sedigheh Delmaghani and Fabrice Giraudet and Christine Petit and Boris Gourévitch and Paul Avan and Nicolas Michalski}, doi = {10.1002/advs.202410776}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2410776}, shortjournal = {Adv. Sci.}, title = {Deciphering auditory hyperexcitability in otogl mutant mice unravels an auditory neuropathy mechanism}, volume = {12}, year = {2025}, }
• (2025). HNF3α targets nckap1l and promotes renal fibrosis following ischemia-reperfusion injury. ADVS, 12(19), 2410764. (www)

  @article{ , abstract = {Chronic Kidney Disease (CKD) is a global health challenge, with acute kidney injury (AKI) from ischemia-reperfusion injury (IRI) as a common cause. This study explored the role of Hepatocyte Nuclear Factor 3 alpha (HNF3α/FOXA1) in renal fibrosis and CKD after IRI. Kidney biopsy specimens from CKD patients and mouse models (IRI or unilateral ureteral obstruction) showed HNF3α upregulation in fibrotic kidneys, linked to renal function decline. Additional experiments demonstrated that deletion of HNF3α mitigated IRI-induced renal fibrosis, and that overexpression of HNF3α led to increased fibrosis. Examination of the potential mechanism by transcriptome sequencing and CUT&Tag sequencing suggested that HNF3α promoted renal fibrosis by increasing the expression of the NCK associated protein 1 like (Nckap1l, formerly known as hematopoietic protein 1 [Hem1]), a vital component of the WAVE complex which plays a significant role in cytoskeletal regulation and cell migration. These results underscore the critical function of HNF3α in renal fibrosis following IRI, and also identify Nckap1l as a potential therapeutic target, thus opening new avenues for research and potential therapeutic interventions for CKD and renal fibrosis.}, archive = {J_ADVS}, author = {Ling Hou and Yan Guo and Shuang Xu and Mi Bai and Weidong Cao and Yue Zhang and Zhanjun Jia and Aihua Zhang}, doi = {10.1002/advs.202410764}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2410764}, shortjournal = {Adv. Sci.}, title = {HNF3α targets nckap1l and promotes renal fibrosis following ischemia-reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Advancements in biochar as a sustainable adsorbent for water pollution mitigation. ADVS, 12(19), 2410383. (www)

  @article{ , abstract = {Biochar, a carbon-rich material produced from the partial combustion of biomass wastes is often termed “black gold” for its potential in water pollution mitigation and carbon sequestration. By customizing biomass feedstock and optimizing preparation strategies, biochar can be engineered with specific physicochemical properties to enhance its effectiveness in removing contaminants from wastewater. Recent studies demonstrate that biochar can achieve > 90% removal efficiency for heavy metals such as lead and cadmium, > 85% adsorption capacity for organic pollutants such as dyes and phenols, and > 80% reduction in microplastics and nanoplastics. This review explores recent advancements in biochar preparation technologies, such as pyrolysis, carbonization, gasification, torrefaction, and rectification, along with physical, chemical, and biological modifications that are crucial for efficient pollutant removal. The core of this review focuses on biochar's applications in removing a wide range of pollutants from wastewater, detailing mechanisms for organic pollutants, inorganic salts, pharmaceutical contaminants, microplastics, nanoplastics, and volatile organic compounds. In addition, the review introduces machine learning as a key technique for optimizing biochar production and functionality, showcasing its potential in advancing biochar technology. The conclusion provides a comprehensive outlook on biochar's future, emphasizing ongoing research and its role in sustainable environmental management.}, archive = {J_ADVS}, author = {Devika Laishram and Su-Bin Kim and Seul-Yi Lee and Soo-Jin Park}, doi = {10.1002/advs.202410383}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2410383}, shortjournal = {Adv. Sci.}, title = {Advancements in biochar as a sustainable adsorbent for water pollution mitigation}, volume = {12}, year = {2025}, }
• (2025). DNA origami-cyanine nanocomplex for precision imaging of KRAS-mutant pancreatic cancer cells. ADVS, 12(19), 2410278. (www)

  @article{ , abstract = {Selective delivery of imaging agents to pancreatic cancer cells (PCCs) within the highly desmoplastic tumors of pancreatic ductal adenocarcinoma (PDAC) represents a significant advancement. This approach allows for precise labeling of PCCs while excluding cancer-associated fibroblasts (CAFs), thereby enhancing both research and diagnostic capabilities. Additionally, it holds the potential to target and eliminate PCCs precisely without harming the surrounding stromal cells in the PDAC tumor microenvironment (TME). In this study, DNA origami-cyanine (Do-Cy) nanocomplexes are synthesized to image KRAS-mutant PCCs selectively in the PDAC TME. These Do-Cy nanocomplexes are hypothesized to be internalized preferentially to KRAS-mutant PCCs over CAFs via elevated macropinocytosis. Several designs of Do-Cy nanocomplexes are synthesized and characterized their cellular uptake using both engineered in vitro and xenograft pancreatic cancer models. The results are further discussed for the implication of precision delivery of therapeutic and imaging agents to KRAS-mutant cancers.}, archive = {J_ADVS}, author = {Hye-ran Moon and Yancheng Du and Sae Rome Choi and Seongmin Seo and Cih Cheng and Bennett D. Elzey and Jong Hyun Choi and Bumsoo Han}, doi = {10.1002/advs.202410278}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2410278}, shortjournal = {Adv. Sci.}, title = {DNA origami-cyanine nanocomplex for precision imaging of KRAS-mutant pancreatic cancer cells}, volume = {12}, year = {2025}, }
• (2025). The awakening brain is characterized by a widespread and spatiotemporally heterogeneous increase in high frequencies. ADVS, 12(19), 2409608. (www)

  @article{ , abstract = {Morning awakening is part of everyday life. Surprisingly, information remains scarce on its underlying neurophysiological correlates. Here simultaneous polysomnography and stereo-electroencephalography recordings from 18 patients are used to assess the spectral and connectivity content of the process of awakening at a local level 15 min before and after the awakening. Awakenings from non-rapid eye movement sleep are accompanied by a widespread increase in ripple (>80 Hz) power in the fronto-temporal and parieto-insular regions, with connectivity showing an almost exclusive increase in the ripple band in the somatomotor, default, dorsal attention, and frontoparietal networks. Awakenings from rapid eye movement sleep are characterized by a widespread and almost exclusive increase in the ripple band in all available brain lobes, and connectivity increases mainly in the low ripple band in the limbic system as well as the default, dorsal attention, somatomotor, and frontoparietal networks.}, archive = {J_ADVS}, author = {Tamir Avigdor and Guoping Ren and Chifaou Abdallah and François Dubeau and Christophe Grova and Birgit Frauscher}, doi = {10.1002/advs.202409608}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2409608}, shortjournal = {Adv. Sci.}, title = {The awakening brain is characterized by a widespread and spatiotemporally heterogeneous increase in high frequencies}, volume = {12}, year = {2025}, }
• (2025). Inhibition of aberrant activated fibroblast-like synoviocytes in rheumatoid arthritis by leishmania peptide via the regulation of fatty acid synthesis metabolism. ADVS, 12(19), 2409154. (www)

  @article{ , abstract = {The Leishmania homolog of receptors for activated C kinase (LACK) protein is derived from Leishmania parasites L. major . The polypeptide LACK 156–173 has been shown to confer protection against murine autoimmune arthritis. Fibroblast-like synoviocytes (FLSs) play a pivotal role in the synovial invasion and joint destruction observed in rheumatoid arthritis (RA). The study reveals that LACK 156-173 can inhibit the aggressive phenotype of RA-FLSs by restoring dysregulated fatty acid synthesis metabolism. In RA-FLSs, overexpression of fatty acid synthase (FASN) leads to excessive fatty acid accumulation, which in turn promotes mitochondrial fragmentation by enhancing phosphorylation at the ser616 site of dynamin 1-like protein (DRP1). This process increases reactive oxygen species (ROS) production and activates the PI3K/mTOR/NF-κB pathway, thereby facilitating the transition of RA-FLSs to an aggressive inflammatory and bone-damaging phenotype. LACK 156-173 is internalized into the cytoplasm via CAPN2-mediated endocytosis, where it directly binds to FASN and inhibits its activity. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in RA. LACK 156-173 may therefore hold therapeutic promise for RA patients.}, archive = {J_ADVS}, author = {Jianling Su and Xuemei Fan and Yaoyao Zou and Guangtao Fu and Shiqi Feng and Xiaoxue Wang and Yongmei Yu and Lin Li and Zhenhua Bian and Rongrong Huang and Linmang Qin and Jiping Chen and Qin Zeng and Kai Yan and Caiyue Gao and Zhexiong Lian and Xin Li and Yang Li}, doi = {10.1002/advs.202409154}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2409154}, shortjournal = {Adv. Sci.}, title = {Inhibition of aberrant activated fibroblast-like synoviocytes in rheumatoid arthritis by leishmania peptide via the regulation of fatty acid synthesis metabolism}, volume = {12}, year = {2025}, }
• (2025). Artesunate inhibits neointimal hyperplasia by promoting IRF4 associated macrophage polarization. ADVS, 12(19), 2408992. (www)

  @article{ , abstract = {Vascular restenosis is a serious clinical issue initiated and aggravated by macrophage inflammation, with no effective treatments available, in cardiovascular and autoimmune diseases. However, the untapped mechanisms and new targets that can regulate macrophage polarization and vascular restenosis remain elusive. The research identifies interferon regulatory factor 4 (IRF4) expression as crucial in macrophage polarization during arterial restenosis. Myeloid-specific Irf4 deficiency and overexpression experiments showed that IRF4 promoted M2 macrophage polarization, inhibited M1 macrophage transitions, and disrupted the interaction between macrophages and vascular smooth muscle cells to reduce neointimal hyperplasia by directly upregulating krüppel like factor 4 (KLF4) expression. Artesunate, an FDA-approved drug, is screened as a potent activator of IRF4 expression in M2 polarization, and its treatment attenuated arterial restenosis in rodents and non-human primates. The findings reveal a significant protective role of IRF4 in the development of neointimal hyperplasia by regulating macrophage polarization, and artesunate may be proposed as a novel therapy for vascular restenosis.}, archive = {J_ADVS}, author = {Jinlin Miao and Yule Yong and Zhaohui Zheng and Kui Zhang and Wei Li and Jiayi Liu and Siyi Zhou and Juan-juan Qin and Haoyang Sun and Yatao Wang and Xianghui Fu and Xing Luo and Siyu Chen and Zhi-Gang She and Jingjing Cai and Ping Zhu}, doi = {10.1002/advs.202408992}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2408992}, shortjournal = {Adv. Sci.}, title = {Artesunate inhibits neointimal hyperplasia by promoting IRF4 associated macrophage polarization}, volume = {12}, year = {2025}, }
• (2025). Self-assembly engineering of fullerene-like polyhedra: V60, v66, v72 from {MV5} pentagonal second building block. ADVS, 12(19), 2408863. (www)

  @article{ , abstract = {The synthesis of hollow fullerene-like cages has always been an attractive goal for researchers. Nevertheless, such molecular design blueprints are often hampered by the unmet customization of assembly strategy and suitable five-membered ring molecular tiles for building spheres. Herein, a novel spherical molecular cage V 60 -MOP is successfully built by connecting 12 homo-metallic pentagonal {V 5 S} tiles with benzene-1,3,5-tricarboxylate (BTC) ligands through coordination-driven self-assembly and exhibits a similar geometry to the C 60 molecule. As far as is known, this {V 5 S} cluster with the shape of a hollow pentagram is entirely new and is first discovered in metal–organic polyhetra (MOPs). The other two pentagonal motifs are also customized by inserting [VO 5 ] or [MoO 5 ] in the center of {V 5 S} through in situ modification, which also led to another isomorphic V 72 -MOP and V 60 Mo 12 -MOP fullerene-like cages. The three spherical cages reported above all exhibit regular icosahedral symmetry. Notably, a fascinating structure V 66 -MOP is constructed from two different pentagonal motifs {V 5 S} and {VV 5 S}, with reduced symmetry, although the molecule remains a sphere in appearance, which is rare in fullerene-shaped structures. In addition, the series of fullerene-like V-MOPs are active in the oxidation of sulfides to produce sulfoxides or sulfones with high conversion.}, archive = {J_ADVS}, author = {Hongmei Gan and Linyan Bao and Na Xu and Baoshan Hou and Xinlong Wang and Zhongmin Su}, doi = {10.1002/advs.202408863}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2408863}, shortjournal = {Adv. Sci.}, title = {Self-assembly engineering of fullerene-like polyhedra: V60, v66, v72 from {MV5} pentagonal second building block}, volume = {12}, year = {2025}, }
• (2025). Elastic relaxation of coherent InGaN/GaN interfaces at the microwire LED sidewall. ADVS, 12(19), 2408736. (www)

  @article{ , abstract = {Elastic relaxation of lattice misfit strain via traction-free surface results in complex 3D strain distribution and morphological modification at the boundary of epitaxial heterostructure. While this phenomenon is extensively studied, the influence of the interface coherency constraining the strain relaxation has received little attention. Here it is shown that the interfacial shear stresses arise toward the traction free sidewall of microscale light emitting diode (LED) wires while the two complementary strained InGaN and GaN layers are relaxed to revert their bulk lattice parameters near the sidewall. The shear stresses with opposite signs achieve mechanical equilibrium by counterbalancing the change in the sign of the in-plane strain in each layer of the near-surface region. A unique nonmonotonic modulation of both normal and shear strain is detected unambiguously in the strain maps and corroborated by finite element modeling. An analytical model is developed based on the Airy stress function, which incorporates the superposition of alternating in-plane pre-stress and the image stress to satisfy the boundary condition. The resultant complex strain fields in microscale LEDs, where surface emission is dominant, alter strain-induced piezoelectric polarization near the surface, significantly affecting electro-optical efficiency and resulting in spectral broadening and/or wavelength shifts in emitted light.}, archive = {J_ADVS}, author = {Jongil Kim and Jinwook Yeo and Bumsu Park and Jeehun Jeong and Seunghwa Ryu and Sang Ho Oh}, doi = {10.1002/advs.202408736}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2408736}, shortjournal = {Adv. Sci.}, title = {Elastic relaxation of coherent InGaN/GaN interfaces at the microwire LED sidewall}, volume = {12}, year = {2025}, }
• (2025). A 3D genome atlas of genetic variants and their pathological effects in cancer. ADVS, 12(19), 2408420. (www)

  @article{ , abstract = {The hierarchical organization of the eukaryotic genome is crucial for nuclear activities and cellular development. Genetic aberrations can disrupt this 3D genomic architecture, potentially driving oncogenesis. However, current research often lacks a comprehensive perspective, focusing on specific mutation types and singular 3D structural levels. Here, pathological changes from chromosomes to nucleotides are systematically cataloged, including 10 789 interchromosomal translocations (ICTs), 18 863 structural variants (SVs), and 162 769 single nucleotide polymorphisms (SNPs). The multilayered analysis reveals that fewer than 10% of ICTs disrupt territories via potent 3D interactions, and only a minimal fraction of SVs disrupt compartments or intersect topologically associated domain structures, yet these events significantly influence gene expression. Pathogenic SNPs typically show reduced interactions within the 3D genomic space. To investigate the effects of variants in the context of 3D organization, a two-phase scoring algorithm, 3DFunc, is developed to evaluate the pathogenicity of variant–gene pairs in cancer. Using 3DFunc, IGHV3-23′s critical role in chronic lymphocytic leukemia is identified and it is found that three pathological SNPs (rs6605578, rs7814783, rs2738144) interact with DEFA3. Additionally, 3DGAtlas is introduced, which provides a highly accessible 3D genome atlas and a valuable resource for exploring the pathological effects of genetic mutations in cancer.}, archive = {J_ADVS}, author = {Li Tang and Matthew C. Hill and Mingxing He and Junhao Chen and Zirui Wang and Patrick T. Ellinor and Min Li}, doi = {10.1002/advs.202408420}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2408420}, shortjournal = {Adv. Sci.}, title = {A 3D genome atlas of genetic variants and their pathological effects in cancer}, volume = {12}, year = {2025}, }
• (2025). GRP78 nanobody-directed immunotoxin activates innate immunity through STING pathway to synergize tumor immunotherapy. ADVS, 12(19), 2408086. (www)

  @article{ , abstract = {The lack of targetable antigens poses a significant challenge in developing effective cancer-targeted therapies. Cell surface translocation of endoplasmic reticulum (ER) chaperones, such as glucose-regulated protein 78 (GRP78), during malignancy, drug resistance, and ER stress induced by therapies, offers a promising pan-cancer target. To target GRP78, nanobody C5, identified from a phage library and exhibiting high affinity for human and mouse GRP78, is utilized to develop the Pseudomonas exotoxin (PE) immunotoxin C5-PE38. C5-PE38 induced ER stress, apoptosis and immunogenic cell death in targeted cells and showed antitumor efficacy against colorectal cancer and melanoma models without obvious toxicity. Mechanistically, transcriptome profiling showed that C5-PE38 reshaped the tumor immune microenvironment with enhanced innate and adaptive immune response and response to interferon beta. Moreover, C5-PE38-induced cell death could trans-activate STING pathway in dendritic cells and macrophages, promoting CD8 + T cell infiltration. It also sensitizes both primary and metastatic melanomas to anti-PD1 therapy, partly through STING activation. Overall, this study unveils a feasible GRP78 nanobody-directed therapy strategy for single or combinatorial cancer intervention. This work finds that C5-PE38-induced cell death stimulates STING-dependent cytosolic DNA release to promote antitumor immunity, a mechanism not previously reported for PE38, providing valuable insights for its clinical use.}, archive = {J_ADVS}, author = {Huifang Wang and Runhua Zhou and Chengchao Xu and Lingyun Dai and Rui Hou and Liuhai Zheng and Chunjin Fu and Guangwei Shi and Jingwei Wang and Yang Li and Jinpeng Cen and Xiaolong Xu and Le Yu and Yilei Li and Jigang Wang and Qingfeng Du and Zhijie Li}, doi = {10.1002/advs.202408086}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2408086}, shortjournal = {Adv. Sci.}, title = {GRP78 nanobody-directed immunotoxin activates innate immunity through STING pathway to synergize tumor immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Targeting KMT5C suppresses lung cancer progression and enhances the efficacy of immunotherapy. ADVS, 12(19), 2407575. (www)

  @article{ , abstract = {The immune evasion is one major challenge for cancer immunotherapy. Despite considerable advancements in immune checkpoint blockade (ICB) therapies for the advanced non-small cell lung cancer (NSCLC) patients, only a minority of patients receive long-term survival benefit. Here, this work demonstrates that lysine methyltransferase 5C (KMT5C) is a crucial promoter of the NSCLC progression and immune evasion. This work first observes that upregulation of KMT5C in NSCLC correlated with cancer progression and poor patient prognosis. Notably, KMT5C knockdown in NSCLC cells suppress tumor growth and metastasis in mice. Mechanistically, this work demonstrates that KMT5C activated the DNA repair response to inhibit the STING-IRF3 pathway, downstream type I IFN signaling, and CCL5 secretion, leading to the downregulation of CD8 + T cell infiltration and function in NSCLC, ultimately facilitating tumor immune evasion and tumor progression. Importantly, both the pharmacological inhibitor A196 and the genetic inhibition of KMT5C could synergize with anti-PD-1 therapy in the lung cancer mouse model. Clinically, high expression levels of KMT5C in patients with NSCLC are associated with a lower response rate and worse clinical outcomes to ICB therapy. Therefore, these findings identify a previously unknown functional link between KMT5C and tumor immune evasion, and demonstrate that targeting KMT5C may be a potential therapeutic approach for enhancing the efficacy of NSCLC patients to ICB therapy.}, archive = {J_ADVS}, author = {Yunfeng Yuan and Qianyu Li and Guoquan Yan and Yifei Qian and Wenyun Guo and Songling Li and Fan Wang and Wanjing Shang and Zijun Zhu and Di Ge and Yanan Wang and Yanfeng Liu}, doi = {10.1002/advs.202407575}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2407575}, shortjournal = {Adv. Sci.}, title = {Targeting KMT5C suppresses lung cancer progression and enhances the efficacy of immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Inhalable hsa-miR-30a-3p liposomes attenuate pulmonary fibrosis. ADVS, 12(19), 2405434. (www)

  @article{ , abstract = {Idiopathic pulmonary fibrosis (IPF) remains an incurable form of interstitial lung disease with sub-optimal treatments that merely address adverse symptoms or slow fibrotic progression. Here, inhalable hsa-miR-30a-3p-loaded liposomes (miR-30a) for the treatment of bleomycin-induced pulmonary fibrosis in mice are presented. It was previously found that exosomes (Exo) derived from lung spheroid cells are therapeutic in multiple animal models of pulmonary fibrosis and are highly enriched for hsa-miR-30a-3p. The present study investigates this miRNA as a singular factor to treat IPF. Liposomes containing miR-30a mimic can be delivered to rodents through dry powder inhalation. Inhaled miR-30a and Exo consistently lead to improved pulmonary function across six consecutive pulmonary function tests and promote de-differentiation of profibrotic myofibroblasts. The heterogenous composure of Exo also promotes reparative alveolar type I and II cell remodeling and vascular wound healing through broad transforming growth factor-beta signaling downregulation, while miR-30a targets myofibroblast de-differentiation through CNPY2/PERK/DDIT3 signaling. Overall, inhaled miR-30a represses the epithelial-mesenchymal transition of myofibroblasts, providing fibrotic attenuation and subsequent improvements in pulmonary function.}, archive = {J_ADVS}, author = {Shuo Liu and Kristen D. Popowski and Christina M. Eckhardt and Weihang Zhang and Junlang Li and Yujia Jing and Dylan Silkstone and Elizabeth Belcher and Megan Cislo and Shiqi Hu and Halle Lutz and Asma Ghodsi and Mengrui Liu and Phuong-Uyen C. Dinh and Ke Cheng}, doi = {10.1002/advs.202405434}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2405434}, shortjournal = {Adv. Sci.}, title = {Inhalable hsa-miR-30a-3p liposomes attenuate pulmonary fibrosis}, volume = {12}, year = {2025}, }
• (2025). LightRoseTTA: High-efficient and accurate protein structure prediction using a light-weight deep graph model. ADVS, 12(19), 2309051. (www)

  @article{ , abstract = {Accurately predicting protein structure, from sequences to 3D structures, is of great significance in biological research. To tackle this issue, a representative deep big model, RoseTTAFold, is proposed with promising success. Here, “a light-weight deep graph network, named LightRoseTTA,” is reported to achieve accurate and highly efficient prediction for proteins. Notably, three highlights are possessed by LightRoseTTA: i) high-accurate structure prediction for proteins, being “competitive with RoseTTAFold” on multiple popular datasets including CASP14 and CAMEO; ii) high-efficient training and inference with a light-weight model, costing “only 1 week on one single NVIDIA 3090 GPU for model-training” (vs 30 days on 8 NVIDIA V100 GPUs for RoseTTAFold) and containing “only 1.4M parameters” (vs 130M in RoseTTAFold); iii) low dependency on multi-sequence alignment (MSA), achieving the best performance on three MSA-insufficient datasets: Orphan, De novo, and Orphan25. Besides, LightRoseTTA is “transferable” from general proteins to antibody data, as verified in the experiments. The time and resource costs of LightRoseTTA and RoseTTAFold are further discussed to demonstrate the feasibility of light-weight models for protein structure prediction, which may be crucial in resource-limited research for universities and academic institutions. The code and model are released to speed biological research ( https://github.com/psp3dcg/LightRoseTTA ).}, archive = {J_ADVS}, author = {Xudong Wang and Tong Zhang and Guangbu Liu and Zhen Cui and Zhiyong Zeng and Cheng Long and Wenming Zheng and Jian Yang}, doi = {10.1002/advs.202309051}, journal = {Advanced Science}, month = {5}, number = {19}, pages = {2309051}, shortjournal = {Adv. Sci.}, title = {LightRoseTTA: High-efficient and accurate protein structure prediction using a light-weight deep graph model}, volume = {12}, year = {2025}, }
• (2025). An intracellular peptide library screening platform identifies irreversible covalent transcription factor inhibitors (Adv. sci. 18/2025). ADVS, 12(18), 2570138. (www)

  @article{ , archive = {J_ADVS}, author = {Andrew Brennan and Scott Lovell and Keith W Vance and Jody M Mason}, doi = {10.1002/advs.202570138}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570138}, shortjournal = {Adv. Sci.}, title = {An intracellular peptide library screening platform identifies irreversible covalent transcription factor inhibitors (Adv. sci. 18/2025)}, volume = {12}, year = {2025}, }
• (2025). A rapid cortical learning process supporting students' knowledge construction during real classroom teaching (Adv. sci. 17/2025). ADVS, 12(18), 2570137. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaodan Feng and Xinran Xu and Zhaonan Meng and Jiahao Jiang and Miao Pei and Yonghe Zheng and Chunming Lu}, doi = {10.1002/advs.202570137}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570137}, shortjournal = {Adv. Sci.}, title = {A rapid cortical learning process supporting students' knowledge construction during real classroom teaching (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). Dissecting the spatial and single-cell transcriptomic architecture of cancer stem cell niche driving tumor progression in gastric cancer (Adv. sci. 18/2025). ADVS, 12(18), 2570136. (www)

  @article{ , archive = {J_ADVS}, author = {Guangyu Zhang and Xin Zhang and Wenting Pan and Xizhao Chen and Lingfei Wan and Chunjie Liu and Yuting Yong and Yue Zhao and Shuli Sang and Lihua Zhang and Sheng Yao and Yushu Guo and Mingmei Wang and Xinhui Wang and Guangdun Peng and Xinlong Yan and Yanchun Wang and Min Zhang}, doi = {10.1002/advs.202570136}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570136}, shortjournal = {Adv. Sci.}, title = {Dissecting the spatial and single-cell transcriptomic architecture of cancer stem cell niche driving tumor progression in gastric cancer (Adv. sci. 18/2025)}, volume = {12}, year = {2025}, }
• (2025). Epithelial cell mechanoresponse to matrix viscoelasticity and confinement within micropatterned viscoelastic hydrogels (Adv. sci. 18/2025). ADVS, 12(18), 2570135. (www)

  @article{ , archive = {J_ADVS}, author = {Giuseppe Ciccone and Mariana Azevedo Gonzalez-Oliva and Marie Versaevel and Marco Cantini and Massimo Vassalli and Manuel Salmeron-Sanchez and Sylvain Gabriele}, doi = {10.1002/advs.202570135}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570135}, shortjournal = {Adv. Sci.}, title = {Epithelial cell mechanoresponse to matrix viscoelasticity and confinement within micropatterned viscoelastic hydrogels (Adv. sci. 18/2025)}, volume = {12}, year = {2025}, }
• (2025). Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis (Adv. sci. 18/2025). ADVS, 12(18), 2570134. (www)

  @article{ , archive = {J_ADVS}, author = {Zhihua Ou and Li Li and Peidi Ren and Ting-Ting Zhou and Fan He and Jialing Chen and Huimin Cai and Xiumin Han and Yao-Dong Wu and Jiandong Li and Xiu-Rong Li and Qiming Tan and Wenhui Li and Qi Chen and Nian-Zhang Zhang and Xiuju He and Wei-Gang Chen and Yanping Zhao and Jiwen Sun and Qian Zhang and Yan-Tao Wu and Yingan Liang and Jie You and Guohai Hu and Xue-Qi Tian and Sha Liao and Bao-Quan Fu and Ao Chen and Xue-Peng Cai and Huanming Yang and Jian Wang and Xin Jin and Xun Xu and Wan-Zhong Jia and Junhua Li and Hong-Bin Yan}, doi = {10.1002/advs.202570134}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570134}, shortjournal = {Adv. Sci.}, title = {Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis (Adv. sci. 18/2025)}, volume = {12}, year = {2025}, }
• (2025). Citrullination of NF-κB p65 by PAD2 as a novel therapeutic target for modulating macrophage polarization in acute lung injury (Adv. sci. 18/2025). ADVS, 12(18), 2570132. (www)

  @article{ , archive = {J_ADVS}, author = {Xin Yu and Yujing Song and Tao Dong and Wenlu Ouyang and Chao Quan and Liujiazi Shao and Leonard Barasa and Paul R. Thompson and Mao Zhang and Jianjie Ma and Katsuo Kurabayashi and Yongqing Li}, doi = {10.1002/advs.202570132}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570132}, shortjournal = {Adv. Sci.}, title = {Citrullination of NF-κB p65 by PAD2 as a novel therapeutic target for modulating macrophage polarization in acute lung injury (Adv. sci. 18/2025)}, volume = {12}, year = {2025}, }
• (2025). Broadband, wide-angle, and versatile metasurface illusions with inverse synthetic aperture radar imaging (Adv. sci. 18/2025). ADVS, 12(18), 2570131. (www)

  @article{ , archive = {J_ADVS}, author = {Haoran Li and Kang Luo and Din Ping Tsai and Yulang Li and Linyuan Dou and Shuqiao Li and Tao He and Yuancheng Fan and Mu Ku Chen and Zhanshan Wang and Yuzhi Shi and Zeyong Wei and Xinbin Cheng}, doi = {10.1002/advs.202570131}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570131}, shortjournal = {Adv. Sci.}, title = {Broadband, wide-angle, and versatile metasurface illusions with inverse synthetic aperture radar imaging (Adv. sci. 18/2025)}, volume = {12}, year = {2025}, }
• (2025). High-viability circulating tumor cells sorting from whole blood at single cell level using laser-induced forward transfer-assisted microfiltration (Adv. sci. 18/2025). ADVS, 12(18), 2570130. (www)

  @article{ , archive = {J_ADVS}, author = {Qingmei Xu and Yuntong Wang and Songtao Dou and Yang Xu and Zhenhe Xu and Han Xu and Yi Zhang and Yanming Xia and Ying Xue and Hang Li and Xiao Ma and Kunlong Zhang and Huan Wang and Fengzhou Ma and Qi Wang and Bei Li and Wei Wang}, doi = {10.1002/advs.202570130}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570130}, shortjournal = {Adv. Sci.}, title = {High-viability circulating tumor cells sorting from whole blood at single cell level using laser-induced forward transfer-assisted microfiltration (Adv. sci. 18/2025)}, volume = {12}, year = {2025}, }
• (2025). Multifunctional conductive nanofibers for self-powered glucose biosensors (Adv. sci. 18/2025). ADVS, 12(18), 2570129. (www)

  @article{ , archive = {J_ADVS}, author = {Seda Gungordu Er and Rameesh Bulathsinghala and Selvinaz Burcu Kizilates and Bing Li and Rucchi Ryan and Tanveer A. Tabish and Ishara Dharmasena and Mohan Edirisinghe}, doi = {10.1002/advs.202570129}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2570129}, shortjournal = {Adv. Sci.}, title = {Multifunctional conductive nanofibers for self-powered glucose biosensors (Adv. sci. 18/2025)}, volume = {12}, year = {2025}, }
• (2025). RETRACTION: Profiling of circulating tumor cells for screening of selective inhibitors of tumor-initiating stem-like cells. ADVS, 12(18), 2505952. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202505952}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2505952}, shortjournal = {Adv. Sci.}, title = {RETRACTION: Profiling of circulating tumor cells for screening of selective inhibitors of tumor-initiating stem-like cells}, volume = {12}, year = {2025}, }
• (2025). Correction to [Metal-catalyzed abiotic cleavage of CC bonds for effective fluorescence imaging of Cu(II) and Fe(III) in living systems]. ADVS, 12(18), 2505490. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202505490}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2505490}, shortjournal = {Adv. Sci.}, title = {Correction to [Metal-catalyzed abiotic cleavage of CC bonds for effective fluorescence imaging of Cu(II) and Fe(III) in living systems]}, volume = {12}, year = {2025}, }
• (2025). Microenvironmental modulation for therapeutic efficacy of extracellular vesicles. ADVS, 12(18), 2503027. (www)

  @article{ , abstract = {Extracellular vesicles (EVs) hold significant promise for the prevention and treatment of various diseases. However, the translation of EV-based therapies into clinical practice faces considerable challenges, particularly in terms of production yield and therapeutic efficacy. Recent studies have emphasized the heterogeneity of EVs and the influence of parental cell microenvironmental signals on their biogenesis, cargo composition, and therapeutic outcomes. This review offers a comprehensive overview of strategies to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation. Additionally, it explores how microenvironmental signals affect EV cargoes and the mechanisms by which these signals can improve therapeutic efficacy. The review also addresses current challenges and potential solutions to accelerate the clinical translation of EV therapies. Ultimately, it highlights the potential of microenvironmental modulation in unlocking the full therapeutic capacity of EVs, providing key insights into their production and clinical use for treating various diseases.}, archive = {J_ADVS}, author = {Bilu Xiang and Shiying Zhang and Irene Shuping Zhao and Xueqi Gan and Yang Zhang}, doi = {10.1002/advs.202503027}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2503027}, shortjournal = {Adv. Sci.}, title = {Microenvironmental modulation for therapeutic efficacy of extracellular vesicles}, volume = {12}, year = {2025}, }
• (2025). Multi-stimuli-responsive circularly polarized luminescence with handedness inversion and near-infrared phosphorescence in chiral metal-organic framework platform for white light emission and information encryption. ADVS, 12(18), 2502784. (www)

  @article{ , abstract = {Preparing multi-color and multi-stimuli-responsive circularly polarized luminescence (CPL) materials and understanding the evolution of chirality through the visualized mode is still a challenge. Here, an encapsulation engineering approach of chiral metal-organic frameworks (MOFs) is proposed to confine guest emitters to realize multi-color and multi-stimuli-responsive CPL. Based on triplet-triplet energy transfer (TTET), white CPL and near-infrared circularly polarized room temperature phosphorescence (NIR-CPRTP) can be obtained by introducing the pyrene derivatives. With the introduction of the guest containing vinylpyrene group, the light- and thermal-responsive CPL with the signal inversion can be realized through the reversible [2+2] cycloaddition reaction between the ligand and guest triggered by visible light/ultraviolet light or heating. Furthermore, the excitation-dependent CPL is successfully achieved with the incorporation of excited state intramolecular proton transfer (ESIPT) molecules into nanopores. Importantly, the chirality magnification can be greatly enhanced through the chiral spatial confinement, the accurate host-guest single crystal structures of FLT@DCF-12 and FLT@LCF-12 provide the visualized mode to understand the mechanism of chirality transfer, amplification and responsiveness. White LED and multiple information display and encryption are further demonstrated. This breakthrough provides a new perspective to guest-encapsulated chiral MOFs and contributes to the construction of stimuli-responsive CPL-active materials.}, archive = {J_ADVS}, author = {Kun Zhang and Ni Dan and Ruo-Yu Zhang and Jiaojiao Wei and Rui-Xue Tian and Yongfan Zhang and Hong-Ru Fu and Mei Qiu and Lu-Fang Ma and Shuang-Quan Zang}, doi = {10.1002/advs.202502784}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2502784}, shortjournal = {Adv. Sci.}, title = {Multi-stimuli-responsive circularly polarized luminescence with handedness inversion and near-infrared phosphorescence in chiral metal-organic framework platform for white light emission and information encryption}, volume = {12}, year = {2025}, }
• (2025). Robust stick-and-play photothermal icephobic film with bioinspired insulation cells. ADVS, 12(18), 2502687. (www)

  @article{ , abstract = {The integration of photothermal de-icing and micro/nanostructured anti-icing technologies into a surface is regarded as a promising solution to solve ice accretion aggravated. Unfortunately, light-dependent heat effect and large-scale production of micro/nano building still challenge the anti-icing ability and applications for real-world. Herein, a stick-and-play film embedded with bioinspired thermal-management cells is developed. Inspired by the hollow framework of lotus seedpods, thermal-management hydrophobic microcells (THMC) are designed by incorporating candle soot into insulating porous diatomite. Once embedding such microcells into PDMS substrate, the resulting THMC film delivers effective photothermal effect since the synergy of photothermal and insulation design. COMSOL simulations demonstrate thermal management effect of the “framework” and “photothermal seeds,” which causes increases in the heating rate by 20% and equilibrium temperature by 10%. Moreover, the self-similarity structure of THMCs enable them to have durable hydrophobicity (148.7°) and photothermal effect (79.9 °C) even after repeated abrasions. When a stick-and-play functionality is imparted by designing adjustable milli-suction cups, this THMC film could adhere effectively to various surfaces despite dry and humid conditions while maintaining efficient anti-/de-icing capabilities. This study provides a designing strategy of robust and efficient photothermal films constructed from THMC and finds flexible use for diverse surfaces.}, archive = {J_ADVS}, author = {Xiaohu Xia and Haotian Chen and Yiming Wang and Haidong Yu and Bingsuo Zou and Yabin Zhang}, doi = {10.1002/advs.202502687}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2502687}, shortjournal = {Adv. Sci.}, title = {Robust stick-and-play photothermal icephobic film with bioinspired insulation cells}, volume = {12}, year = {2025}, }
• (2025). Low-coordination configuration single-atom manganese nanozymes for NIR-imaging-oriented efficient catalytic oncotherapy. ADVS, 12(18), 2502664. (www)

  @article{ , abstract = {Single-atom nanozymes (SAzymes) with low coordination structure has more active sites at an atomic level, which is one of the effective strategies to improve the efficiency of tumor catalytic therapy. Herein, it is reported that simple preparation of single-atom manganese-doped carbon dots (SA Mn-CDs) with low coordination (Mn-N 2 ) configuration formed by chelating manganese atoms with ethylenediamine tetraacetic acid (EDTA). SA Mn-CDs show good dispersibility of different solvents, excellent biological safety and stability, and show deep level (34 µm) of two-photon fluorescence imaging ability and exclusive function (Pearson's correlation coefficient: 0.752) of targeting lysosomes at the cellular level. This further promotes the high-efficiency peroxidase (POD)-like activity (SA = 0.64 U mg −1 ) produced by the Fenton-like reaction mediated by SA Mn-CDs and shows excellent ability to kill tumor cells and shrink tumor tissues in vitro and in vivo respectively. This work proves the great potential of SA Mn-CDs nanozyme in near-infrared fluorescence-guided tumor catalytic therapy.}, archive = {J_ADVS}, author = {Peiwei Jin and Dandan Wang and Yijun Lu and Yong Qian and Chengyang Fang and Xiaoxiao Zhang and Junchao Qian and Songnan Qu and Hui Wang}, doi = {10.1002/advs.202502664}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2502664}, shortjournal = {Adv. Sci.}, title = {Low-coordination configuration single-atom manganese nanozymes for NIR-imaging-oriented efficient catalytic oncotherapy}, volume = {12}, year = {2025}, }
• (2025). Overcoming the low-temperature barrier: Controlling Li₂S deposition and enhancing catalysis in lithium-sulfur batteries using island-like Bi₂O₃ on rGO. ADVS, 12(18), 2502045. (www)

  @article{ , abstract = {Low-temperature lithium-sulfur batteries (LSBs) face challenges such as Li₂S accumulation and the slow conversion of lithium polysulfides (LiPSs), significantly affecting their capacity and cycling life. While functionalizing cathode shows potential to overcome these problems, there has been little focus on understanding the deposition behavior of Li₂S at low temperatures and the specific catalysis processes of newly identified platforms. Here we report an island-like Bi₂O₃ uniformly distributed on reduced graphene oxide (IBG) as a sulfur host material. This unique island-like structure increases the contact area between the electrolyte and electrode, thus enhancing Li⁺ transport efficiency. More importantly, the IBG structure exhibits a targeted catalytic ability toward LiPSs at low temperatures, significantly accelerating the conversion of Li₂S₈ to Li₂S₄ and subsequently to Li₂S. Moreover, the nucleation of Li₂S on the IBG cathode follows a progressive mode with fewer nuclei, effectively preventing Li₂S accumulation and enhancing the battery's charge–discharge efficiency. As a result, LSBs using IBG as the sulfur host can operate reliably at extremely low temperatures, down to −60 °C. This remarkable performance broadens the operating temperature range of LSBs and offers valuable insights for selecting high-performance cathode modification materials in the future.}, archive = {J_ADVS}, author = {Hai-Ji Xiong and Ding-Rong Deng and Yu-Lin Luo and Jia-Xi Song and Jin-Wei Yan and Shuang-Lin Cai and Jia Liang and Cheng-Wei Zhu and Ye Zeng and Gui-Fang Li and Yi Li and Wen-Jun Zhang and Mei-Lin Liu and Qi-Hui Wu}, doi = {10.1002/advs.202502045}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2502045}, shortjournal = {Adv. Sci.}, title = {Overcoming the low-temperature barrier: Controlling Li₂S deposition and enhancing catalysis in lithium-sulfur batteries using island-like Bi₂O₃ on rGO}, volume = {12}, year = {2025}, }
• (2025). SUMOylation of SETD8 promotes tumor growth by methylating and stabilizing MYC in bladder cancer. ADVS, 12(18), 2501734. (www)

  @article{ , abstract = {Aberrant transcriptional and epigenetic landscape plays crucial roles in the progression of bladder cancer (BC). However, effective therapeutic targets derived from these processes remain undeveloped. This study pinpoints SET-domain-containing protein 8 (SETD8) as a pivotal gene that promotes bladder tumor growth through a screening with a CRISPR-Cas9 library targeting transcriptional and epigenetic factors. BC patient samples display elevated SETD8 protein expression, and higher expression of SETD8 correlates with poorer prognosis. Further, MYC is identified as a novel substrate for SETD8. Specifically, SETD8 methylates MYC at lysine 412 (K412), disrupting the interaction between MYC and the E3 ubiquitin ligase CHIP, which results in MYC stabilization and ultimately promotes tumor growth both in vitro and in vivo. Moreover, this study uncovers that SUMOylation of SETD8 leads to SETD8 stabilization. The SUMOylated SETD8 further enhances MYC methylation and stabilization via SUMO-SIM interaction. Knocking down SETD8 or using the SETD8 specific inhibitor UNC0379 substantially reduces the protein level of MYC and inhibits the bladder tumor growth in vitro and in vivo. These findings provide strong support for the idea that targeting the SETD8/MYC axis offers a promising therapeutic approach for BC patient.}, archive = {J_ADVS}, author = {Xia Zhang and Zhenxuan Chen and Xiaobo He and Jingxuan Wang and Jianliang Zhong and Yezi Zou and Xianchong Zheng and Yujie Lin and Ruhua Zhang and Tiebang Kang and Liwen Zhou and Yuanzhong Wu}, doi = {10.1002/advs.202501734}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2501734}, shortjournal = {Adv. Sci.}, title = {SUMOylation of SETD8 promotes tumor growth by methylating and stabilizing MYC in bladder cancer}, volume = {12}, year = {2025}, }
• (2025). An electrochemically-driven reconstruction strategy to realize highly crystalline covalent organic frameworks for enhanced hydrogen evolution reaction. ADVS, 12(18), 2501442. (www)

  @article{ , abstract = {Developing diverse methods to approach highly crystalline covalent organic frameworks (COFs) for improvement of their electrocatalytic hydrogen evolution reaction (HER) activity is important but very challenging. Herein, for the first time, an electrochemically-driven reconstruction strategy is demonstrated to convert semi-polymerized low-crystalline COFs into highly crystalline, structurally ordered COFs with enhanced HER activity. In situ and ex situ characterizations reveal that cyclic voltammetry (CV) cycles can promote crystallinity, thereby leading to improved conductivity, increased active site density, and superior stability. As a result, the highly crystalline COF achieves low overpotentials of 103.6 and 219.4 mV at 10 and 50 mA cm −2 , respectively, with excellent stability (1200 h at 50 mA cm −2 ). More importantly, this strategy is generalizable and effective for various imine-linked COFs with different bonding types, significantly improving their crystallinity and HER activity. This work not only establishes a novel method for constructing highly crystalline COFs but also demonstrates the versatility of electrochemically driven structural modulation in enhancing the catalytic performance of COFs.}, archive = {J_ADVS}, author = {Yuxin Ren and Shuang Li and Meidi Wang and Xue-Qian Wu and Ya-Pan Wu and Bojing Sun and Jun Zhao and Fangyuan Kang and Qichun Zhang and Dong-Sheng Li}, doi = {10.1002/advs.202501442}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2501442}, shortjournal = {Adv. Sci.}, title = {An electrochemically-driven reconstruction strategy to realize highly crystalline covalent organic frameworks for enhanced hydrogen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). IL-33-induced TREM2+ macrophages promote pathological new bone formation through CREG1-IGF2R axis in ankylosing spondylitis. ADVS, 12(18), 2500952. (www)

  @article{ , abstract = {Pathological new bone formation is the main cause of disability in ankylosing spondylitis (AS), and so far, it lacks a targeted therapy. Macrophages are central orchestrators of inflammation progression and tissue remodeling, but their contribution to pathological new bone formation has largely not been explored. Here, it is identified that TREM2 + macrophages predominated within the sites of new bone formation and adjacent to osteogenic precursor cells. In vivo, both depletion of macrophages and knockout of Trem2 significantly reduced pathological new bone formation in a collagen antibody-induced arthritis (CAIA) model. Specifically, TREM2 + macrophages promoted osteogenic differentiation of ligament-derived progenitor cells (LDPCs) by secreting CREG1, a secretory glycoprotein involved in cell differentiation and normal physiology. CREG1-IGF2R-PI3K-AKT signaling pathway is involved in TREM2 + macrophage-mediated pathological new bone formation. In addition, it is found that IL-33 promoted TREM2 + macrophage differentiation through phosphorylation of STAT6. Targeting the above signalings alleviated new bone formation in the CAIA model. The findings highlight the critical role of IL-33-induced TREM2 + macrophages in pathological new bone formation and provide potential therapeutic targets for halting spinal ankylosis in AS.}, archive = {J_ADVS}, author = {Wenjun Hao and Siwen Chen and Hua Chao and Zihao Li and Hao Yang and Dongying Chen and Sifang Li and Shuai Zhang and Jingyu Zhang and Jianru Wang and Zemin Li and Xiang Li and Zhongping Zhan and Tangming Guan and Yiwen Zhang and Wende Li and Hui Liu}, doi = {10.1002/advs.202500952}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500952}, shortjournal = {Adv. Sci.}, title = {IL-33-induced TREM2+ macrophages promote pathological new bone formation through CREG1-IGF2R axis in ankylosing spondylitis}, volume = {12}, year = {2025}, }
• (2025). Selective sorting of semiconducting C70@Single-walled carbon nanotube heterostructures with narrow diameter distribution. ADVS, 12(18), 2500933. (www)

  @article{ , abstract = {Consistently arranging molecules within single-walled carbon nanotube (SWCNT) templates shows promise for creating advanced 1D heterostructures, but diameter variations in raw SWCNTs pose a significant challenge. In this work, a precise synthesis of C 70 fullerene-filled SWCNTs (C 70 @SWCNTs) is achieved through vapor-phase filling followed by polymer sorting. As the SWCNT diameter increases, C 70 molecules first stack in a single chain, then form unusual configurations, including staggered double chains and double helices—configurations not observed in bulk C 70 crystals. SWCNT deformation, which is often overlooked in previous theoretical works, is found to significantly alter the C 70 stacking configuration. C 70 -SWCNT electronic interactions, particularly charge transfer, allow selective extraction of C 70 @SWCNTs with narrowly distributed diameters and good semiconducting purity. The sorted C 70 @SWCNTs have diameters of 1.3–1.4 nm, corresponding to C 70 -SWCNT distances of ca. 0.34 nm, where the strongest electronic interactions occur. An on/off current ratio of 10⁴ is achieved in their field-effect transistors. The synthesis and separation strategy sheds light on the preparation and application of 1D heterostructures.}, archive = {J_ADVS}, author = {Yuqi He and Jian Yao and Ye Liu and Feng Jin and Yujie Peng and Zeyuan Nan and Aling Chen and Hehua Jin and Song Qiu and Lixing Kang and Dengsong Zhang and Qingwen Li}, doi = {10.1002/advs.202500933}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500933}, shortjournal = {Adv. Sci.}, title = {Selective sorting of semiconducting C70@Single-walled carbon nanotube heterostructures with narrow diameter distribution}, volume = {12}, year = {2025}, }
• (2025). Ultra-high temperature calcination of crystalline α-Fe2O3 and its nonlinear optical properties for ultrafast photonics. ADVS, 12(18), 2500896. (www)

  @article{ , abstract = {As a typical transition metal oxide, α-Fe 2 O 3 has garnered significant attention due to its advantages in nonlinear optical applications, such as strong third-order nonlinearity and fast carrier recovery time. To delve into the nonlinear optical properties of α-Fe 2 O 3 , crystalline α-Fe 2 O 3 materials with different microstructures are prepared. The nonlinear optical features of α-Fe 2 O 3 calcined at the previously unexplored ultra-high temperature of >1100°C are emphasized. It is found that α-Fe 2 O 3 exposed to ultra-high temperatures undergoes the phase transition, leading to the formation of Fe 3 O 4 . Subsequently, the nonlinear absorption coefficient is measured as −0.6280 cm GW −1 at 1.5 µm. The modulation depth and saturation intensity for the Fe 2 O 3 -based saturable absorber at 1.5 µm are 4.20% and 13.94 MW cm −2 , respectively. Ultimately, the incorporation of the Fe 2 O 3 -based saturable absorber into an Er-doped fiber laser cavity resulted in the achievement of both conventional soliton mode-locking operation with a central wavelength of 1560.3 nm and a pulse duration of 1.13 ps, as well as the dissipative soliton resonance mode-locking operation with a central wavelength near 1564.0 nm. Overall, the phase transition and the nonlinear optical features in iron oxides under ultra-high temperatures are revealed, indicating the great potential in advanced ultrafast photonic applications.}, archive = {J_ADVS}, author = {Qingxi Zhao and Qingling Tang and Hongwei Chu and Zhongben Pan and Han Pan and Shengzhi Zhao and Dechun Li}, doi = {10.1002/advs.202500896}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500896}, shortjournal = {Adv. Sci.}, title = {Ultra-high temperature calcination of crystalline α-Fe2O3 and its nonlinear optical properties for ultrafast photonics}, volume = {12}, year = {2025}, }
• (2025). Replicating PET hydrolytic activity by positioning active sites with smaller synthetic protein scaffolds. ADVS, 12(18), 2500859. (www)

  @article{ , abstract = {Evolutionary constraints significantly limit the diversity of naturally occurring enzymes, thereby reducing the sequence repertoire available for enzyme discovery and engineering. Recent breakthroughs in protein structure prediction and de novo design, powered by artificial intelligence, now enable to create enzymes with desired functions without solely relying on traditional genome mining. Here, a computational strategy is demonstrated for creating new-to-nature polyethylene terephthalate hydrolases (PET hydrolases) by leveraging the known catalytic mechanisms and implementing multiple deep learning algorithms and molecular computations. This strategy includes the extraction of functional motifs from a template enzyme (here leaf-branch compost cutinase, LCC, is used), regeneration of new protein sequences, computational screening, experimental validation, and sequence refinement. PET hydrolytic activity is successfully replicated with designer enzymes that are at least 30% shorter in sequence length than LCC. Among them, Rs PETase1 stands out due to its robust expressibility. It exhibits comparable catalytic efficiency ( k cat / K m ) to LCC and considerable thermostability with a melting temperature of 56 °C, despite sharing only 34% sequence similarity with LCC. This work suggests that enzyme diversity can be expanded by recapitulating functional motifs with computationally built protein scaffolds, thus generating opportunities to acquire highly active and robust enzymes that do not exist in nature.}, archive = {J_ADVS}, author = {Yujing Ding and Shanshan Zhang and Xian Kong and Henry Hess and Yifei Zhang}, doi = {10.1002/advs.202500859}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500859}, shortjournal = {Adv. Sci.}, title = {Replicating PET hydrolytic activity by positioning active sites with smaller synthetic protein scaffolds}, volume = {12}, year = {2025}, }
• (2025). Triple-stimuli responsive soft robots with photo-programmable ferriferous oxide particle patterns. ADVS, 12(18), 2500669. (www)

  @article{ , abstract = {Magneto-driven soft robots featuring remote and highly permeable controllability are considered promising, especially in biomedical and engineering applications. However, there is still lack of a high-precision method to regulate the distribution of magnetic fillers in polymer substrates, which severely limits the improvement of the actuating functionality. This work provides a photo-regulatable method to develop soft robots with locally distributed magnetic Fe 3 O 4 nanoparticles. Solvent-casted polyvinyl alcohol/sodium carboxymethyl cellulose film is prepared as the substrate, and Fe 3+ ions are introduced to coordinate with carboxylate groups by surface treatment. Two processes, photo-reduction of Fe 3+ to Fe 2+ ions and the hydrolytic reaction of the two ions, are sequentially combined to in situ generate magnetic Fe 3 O 4 particles. Spatiotemporal control of UV light irradiation determines the Fe 3+ /Fe 2+ ratio and, therefore the amount of generated Fe 3 O 4 nanoparticles that decide magnetic field, NIR light, and moisture responsive actuating functionalities. Moreover, the external geometry of the composite can be tuned by inducing the formation of Al 3+ -carboxylate coordinates for strain retention, which enables shape programming of the composite to exhibit complex 3D–3D actuating behaviors. The proposed method enables the design and preparation of soft robots with spatially tunable magnetism and more advanced actuating behaviors.}, archive = {J_ADVS}, author = {Siwei Hu and Kexing Li and Weijia Nong and Zhong-Wen Liu and Zhao-Tie Liu and Yanhu Zhan and Jinqiang Jiang and Peng Yang and Guo Li}, doi = {10.1002/advs.202500669}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500669}, shortjournal = {Adv. Sci.}, title = {Triple-stimuli responsive soft robots with photo-programmable ferriferous oxide particle patterns}, volume = {12}, year = {2025}, }
• (2025). Imaging-guided microscale photothermal stereolithography bioprinting. ADVS, 12(18), 2500640. (www)

  @article{ , abstract = {Stereolithography bioprinting relies heavily on costly photoinitiators for polymerization, limiting its potential for further technical advancement to meet growing needs in tissue engineering and regenerative medicine. Thermal initiators, in contrast, are low cost, and rapid growth of the photothermal conversion field offers a wide range of materials and tools to convert light into heat. However, high-resolution photothermal stereolithography bioprinting remains unattainable due to the difficulty of confining heat in an aqueous environment. Here, this challenge has been fully addressed by establishing imaging-guided microscale photothermal stereolithography bioprinting (ImPSB). This technique is achieved through building a novel imaging-guided stereolithography system that provides depth-resolved visualization of the printing dynamics, creating a unique photothermal initiator in the second near-infrared window, and developing a new bioink by seeing and controlling the photothermal gelation process. ImPSB achieves a printing resolution of ≈47 µm and generates smooth lines of arbitrarily designed shapes with a cross-sectional diameter as small as ≈104 µm, representing an unprecedented scale from photothermal aqueous stereolithography. Its cellular biocompatibility in printing both bioscaffold and cell-laden hydrogel is demonstrated, and its feasibility of transdermal printing is also shown. This work sets a new path for high-resolution stereolithography bioprinting where the vast photothermal resources can be utilized.}, archive = {J_ADVS}, author = {Jingyu Sun and Tianqi Fang and Yuze Zhang and Jue Wang and Huan Han and Tsengming Chou and Junfeng Liang and Dilhan M. Kalyon and Hongjun Wang and Shang Wang}, doi = {10.1002/advs.202500640}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500640}, shortjournal = {Adv. Sci.}, title = {Imaging-guided microscale photothermal stereolithography bioprinting}, volume = {12}, year = {2025}, }
• (2025). Dual-atom catalyst Au@S-rGO for rapid and highly sensitive electrochemical detection of fentanyl in serum. ADVS, 12(18), 2500430. (www)

  @article{ , abstract = {Fentanyl is a highly lethal emerging drug that requires urgent rapid trace detection. In this work, high-sensitivity detection of fentanyl is achieved by Au- and S-doped reduced graphene oxide (Au@S-rGO). Spherical electron microscopy revealed that Au and S existed in an atomically dispersed state. The possible configurations of S in Au@S-rGO, as well as the effects of different doping positions on the electron density of Au, are analyzed by Density functional theory (DFT) simulations. The co-modification of metal and nonmetal atoms significantly improves the catalytic activity of the electrode. The optimal electrode delivers a good linear relationship for fentanyl concentrations from 0.0291 to 38.2 µmol L-1, with a detection limit of 9.7 nmol L-1. The recovery rate of fentanyl in human serum ranged from 98.0% to 104%, demonstrating the precision of the sensor in real biological matrices. Furthermore, by employing rats in place of drug addicts, the coincidence rate between the electrochemical test results and the mass spectrometry results was 85.7% ~ 93.6%. Compared with mass spectrometry, the sensor offers faster, simpler, and more cost-effective onsite detection. In summary, the novel diatomic catalyst design looks excellent for fabricating electrochemical sensors for the rapid detection of fentanyl in real samples.}, archive = {J_ADVS}, author = {Meng Li and ZhiJin Fan and Qiuxia Gao and Ying He and Anyun Xu and Zhaofeng Gu and Shixiong Wang and Huiping Bai and Yuhui Liao and Ruilin Zhang}, doi = {10.1002/advs.202500430}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500430}, shortjournal = {Adv. Sci.}, title = {Dual-atom catalyst Au@S-rGO for rapid and highly sensitive electrochemical detection of fentanyl in serum}, volume = {12}, year = {2025}, }
• (2025). Gram-scale preparation of tri-coordinated single-atom catalysts for CO2 electrolysis in large-scale membrane electrode assembly. ADVS, 12(18), 2500368. (www)

  @article{ , abstract = {Accelerating the commercialization of CO 2 electroreduction is essential for carbon utilization, yet it faces challenges of precious metal catalysts cost and scaling-up of the corresponding devices. In this study, a low-cost and tri-coordinated single-atom catalyst (SAC) with Ni-N3 center is fabricated in gram-scale using metal ionic liquids as precursor. The gram-scale Ni-N3 SAC (g-NiN3) achieves efficient electroreduction of CO 2 to CO (eCO 2 -to-CO) with a maximum Faradaic efficiency of 98.9% at 2.8 V in a 2 × 2 cm 2 membrane electrode assembly (MEA) cell, and CO selectivity exceeds 90% during 100 h electrolysis at 100 mA·cm −2 . Moreover, the g-NiN3 is tested in a scale-up MEA reactor (10 × 10 cm 2 ), which can not only show 97.1% CO Faradaic efficiency with a reaction current of 6.07 A but also achieves a CO 2 single-pass conversion of 41.0%, corresponding to energy efficiency of the system as high as 43.1%. The overall performance of g-NiN3 is one of the state-of-the-art systems for eCO 2 -to-CO. In addition, the scale-up device stably generates CO at a high rate of 12.0 L·kW·h −1 over continuous CO 2 electrolysis. The techno-economic assessment demonstrates that the eCO 2 -to-CO using g-NiN3 can realize CO production cost of 1.08 $·kg −1 , and shows great profitability prospects in the future.}, archive = {J_ADVS}, author = {Lei Yuan and Xin Li and Guilin Li and Kuilin Peng and Hongyu Zhang and Shaojuan Zeng and Xiaofu Sun and Xiangping Zhang}, doi = {10.1002/advs.202500368}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500368}, shortjournal = {Adv. Sci.}, title = {Gram-scale preparation of tri-coordinated single-atom catalysts for CO2 electrolysis in large-scale membrane electrode assembly}, volume = {12}, year = {2025}, }
• (2025). Indium-doping advances high-performance flexible Ag2Se thin films. ADVS, 12(18), 2500364. (www)

  @article{ , abstract = {Enhancing the thermoelectric performance of Ag 2 Se thin films via physical vapor deposition remains challenging. In this study, a precursor doping strategy is introduced to fabricate In-doped Ag 2 Se thin films. In substitutional doping at the Ag cation sites increases the charge density distribution of Ag 2 Se, improving electrical conductivity, while maintaining a high Seebeck coefficient and relatively low thermal conductivity. This approach yields a competitive room-temperature power factor of ≈26.3 µW cm −1 K −2 and a ZT value approaching 1. The films, supported by a polyimide substrate and optimized for thickness, exhibit uniform composition and excellent flexibility, retaining over 90% of their initial electrical conductivity after 500 bending cycles with a 5 mm bending radius. Additionally, a five-leg flexible thermoelectric device constructed from these films achieves a power density of up to 630.6 µW cm −2 under a temperature difference of 18 K, corresponding to a normalized power density of nearly 2 µW cm −2 K −2 , highlighting its potential for practical applications.}, archive = {J_ADVS}, author = {Tianyi Cao and Xiao-Lei Shi and Boxuan Hu and Siqi Liu and Wanyu Lyu and Meng Li and Sen Wang and Wenyi Chen and Wei-Di Liu and Raza Moshwan and Tuquabo Tesfamichael and Jennifer MacLeod and Zhi-Gang Chen}, doi = {10.1002/advs.202500364}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500364}, shortjournal = {Adv. Sci.}, title = {Indium-doping advances high-performance flexible Ag2Se thin films}, volume = {12}, year = {2025}, }
• (2025). The encapsulation strategies for targeted delivery of probiotics in preventing and treating colorectal cancer: A review. ADVS, 12(18), 2500304. (www)

  @article{ , abstract = {Colorectal cancer (CRC) ranks as the third most prevalent cancer worldwide. It is associated with imbalanced gut microbiota. Probiotics can help restore this balance, potentially reducing the risk of CRC. However, the hostile environment and constant changes in the gastrointestinal tract pose significant challenges to the efficient delivery of probiotics to the colon. Traditional delivery methods are often insufficient due to their low viability and lack of targeting. To address these challenges, researchers are increasingly focusing on innovative encapsulation technologies. One such approach is single-cell encapsulation, which involves applying nanocoatings to individual probiotic cells. This technique can improve their resistance to the harsh gastrointestinal environment, enhance mucosal adhesion, and facilitate targeted release, thereby increasing the effectiveness of probiotic delivery. This article reviews the latest developments in probiotic encapsulation methods for targeted CRC treatment, emphasizing the potential benefits of emerging single-cell encapsulation techniques. It also analyzes and compares the advantages and disadvantages of current encapsulation technologies. Furthermore, it elucidates the underlying mechanisms through which probiotics can prevent and treat CRC, evaluates the efficacy and safety of probiotics in CRC treatment and adjuvant therapy, and discusses future directions and potential challenges in the targeted delivery of probiotics for CRC treatment and prevention.}, archive = {J_ADVS}, author = {Hao Zhong and Jin Jiang and Muhammad Hussain and Haoxuan Zhang and Ling Chen and Rongfa Guan}, doi = {10.1002/advs.202500304}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500304}, shortjournal = {Adv. Sci.}, title = {The encapsulation strategies for targeted delivery of probiotics in preventing and treating colorectal cancer: A review}, volume = {12}, year = {2025}, }
• (2025). Biomimetic microstructured scaffold with release of re-modified teriparatide for osteoporotic tendon-to-bone regeneration via balancing bone homeostasis. ADVS, 12(18), 2500144. (www)

  @article{ , abstract = {Osteoporotic tendon-to-bone interface healing is challenging, with a high surgical repair failure rate of up to 68%. Conventional tissue engineering approaches have primarily focused on promoting interface healing by stimulating regeneration in either the tendon or bone. However, these methods often fall short of achieving optimal therapeutic outcomes due to their neglect of balancing bone homeostasis and remodeling the microstructure at the osteoporotic tendon-to-bone interface. Herein, a series of site-specific functional modifications are carried out on teriparatide to develop recombinant human parathyroid hormone (R-PTH). A biomimetic microstructured reconstruction scaffold (BMRP) is constructed using a decalcified mussel shell scaffold, pre-gel, and R-PTH. The BMRP mimics the microstructures of the native tendon-to-bone interface and restores the original structure of the interface tissue by repairing injured cells, balancing bone homeostasis, and remodeling the microstructure of the osteoporotic tendon-to-bone interface. In an osteoporotic rotator cuff tear model, BMRP is in situ implanted at the injured site, resulting in structural reconstruction and functional recovery. The BMRP demonstrates excellent repair effects, representing a novel therapeutical alternative for treating osteoporotic tendon-to-bone injury potential for clinical application.}, archive = {J_ADVS}, author = {Chengzhong Xu and Sijie Qiu and Zhigen Yuan and Chongyin Qiu and Wenyu Xu and Jialiang Guo and Gen Wen and Shuai Liu and Wenjuan Yan and Haibing Xu and Honghao Hou and Dehong Yang}, doi = {10.1002/advs.202500144}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500144}, shortjournal = {Adv. Sci.}, title = {Biomimetic microstructured scaffold with release of re-modified teriparatide for osteoporotic tendon-to-bone regeneration via balancing bone homeostasis}, volume = {12}, year = {2025}, }
• (2025). A bio-adaptive janus-adhesive dressing with dynamic lubrication overlayer for prevention of postoperative infection and adhesion. ADVS, 12(18), 2500138. (www)

  @article{ , abstract = {Wound postoperative infection and adhesion are prevalent clinical conditions resulting from surgical trauma. However, integrating intraoperative repair and postoperative management into a dressing suitable for wounds with unpredictable surface shapes and surroundings remains a formidable challenge. Here, we attempt to introduce a dynamic antifouling surface as wound protective covering and report an in situ formation of slippery-adhesive Janus gel (SAJG) by assembling hydrogel (N-hydrosuccinimide ester-activated powders) and elastomer (Silicon oil-infused polydimethylsiloxane). First powders can rapidly absorb interfacial water to gel and bond to tissue based on network entanglement, forming a tough adhesive hydrogel. Then precured organosilicon is applied to hydrogel and bonded together, forming a slippery elastomer. Due to the molecular polarity difference between hydrogel and elastomer, SAJG exhibits anisotropic surface behavior as evidenced by liquid repellency (hydrophilic vs. hydrophobic), and adhesion performance (bioadhesion vs. antiadhesion). Further, in vivo models are constructed and results demonstrated that the SAJG can effectively prevent bacterial infection to promote wound healing and avoid postoperative adhesion. Predictably, the morphologically adaptive SAJG with slippery and adhesive properties will have tremendous potential in addressing complex wound infections and postoperative complications.}, archive = {J_ADVS}, author = {Yuan Gao and Junchang Guo and Shuangyang Li and Liansong Ye and Binyang Lu and Jiaxin Liu and Jing Luo and Yijia Zhu and Liuxiang Chen and Tingfa Peng and Jinlong Yang and Dehui Wang and Chaoming Xie and Xu Deng and Bing Hu}, doi = {10.1002/advs.202500138}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2500138}, shortjournal = {Adv. Sci.}, title = {A bio-adaptive janus-adhesive dressing with dynamic lubrication overlayer for prevention of postoperative infection and adhesion}, volume = {12}, year = {2025}, }
• (2025). Biomineralization-inspired membranization toward structural enhancement of coacervate community. ADVS, 12(18), 2417832. (www)

  @article{ , abstract = {The design and assembly of protocell models that can mimic the features and functions of life present a significant research challenge with the potential for far-reaching impact. Inspired by the natural phenomenon of microbe-induced mineralization, a way is developed to induce the spontaneous formation of mineralized membrane on the surface of coacervate droplets utilizing Fe 3+ ions. In particular, the effect of Fe 3+ ions on the microstructure of droplets at the molecular level is dissected by combining theoretical and experimental approaches. The reversible formation process of membrane can be regulated by redox reactions involving Fe 2+ /Fe 3+ ions within the coacervate. The formation of mineralized membrane not only enhances the stability of the coacervate droplets and prevents aggregation and coalescence, but also allows the aggregation of adjacent droplets together. The membranized coacervate assemblages retain the inherent properties of biomolecule sequestration and enzyme catalysis, and also demonstrate excellent resistance to high temperatures and pressures as well as good stability for over 30 days. This study will offer a new platform for the assembly of coacervate-based life-like biomimetic systems, as well as enhance the understanding of the interactions underlying various biological phenomena at the molecular level.}, archive = {J_ADVS}, author = {Chunyu Zhao and Xiaoliang Wang and Lianning Li and Hu Huang and Bingzhao Wu and Lei Zhang and Xin Huang}, doi = {10.1002/advs.202417832}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2417832}, shortjournal = {Adv. Sci.}, title = {Biomineralization-inspired membranization toward structural enhancement of coacervate community}, volume = {12}, year = {2025}, }
• (2025). Hyperbolic topological quantum sources. ADVS, 12(18), 2417708. (www)

  @article{ , abstract = {Robust Integrable Quantum Optical Sources, Constructed by Topological Boundary States, Are Crucial for the on-chip Quantum Information Processing. However, Limited by the Bulk-edge Correspondence, the Implementation of Topological Boundary Channels Necessitates a Substantial Number of Bulk Sites, Which Notably Diminishes the Ratio of Ring Resonators to Generate Quantum Sources. How to Achieve Topologically-protected Quantum Sources With the Extremely Enhanced Utilization Efficiency of Optical Resonators Remains a Challenge. Here, the First Realization of Hyperbolic Topological Quantum Sources is reported, Which Possess a Dominated Number of Boundary Resonators Than That in the Bulk Domain. Specifically, Hyperbolic Topological Quantum Sources Require Fewer Resources (i.e., the number of ring resonators) to Achieve the Same Level of Brightness Compared With Euclidean Topological Quantum Sources. Furthermore, the Robust Correlated- and Entangled-photon Pairs Are Measured. The Work Possesses Potential Applications in Integrable Quantum Circuits and Suggests a Novel Way on the Exploration of Quantum Physics in Non-Euclidean Space.}, archive = {J_ADVS}, author = {Lu He and Lei Huang and Weixuan Zhang and Dongning Liu and Huizhen Zhang and Xue Feng and Fang Liu and Kaiyu Cui and Yidong Huang and Wei Zhang and Xiangdong Zhang}, doi = {10.1002/advs.202417708}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2417708}, shortjournal = {Adv. Sci.}, title = {Hyperbolic topological quantum sources}, volume = {12}, year = {2025}, }
• (2025). Silk fibroin nanoparticles for enhanced cuproptosis and immunotherapy in pancreatic cancer treatment. ADVS, 12(18), 2417676. (www)

  @article{ , abstract = {Cuproptosis is a newly discovered copper ion-dependent programmed cell death. Elesclomol (ES) is a Cu 2+ transporter that delivers Cu 2+ into tumor cells, causing cell death at toxic doses. However, ES has a short blood half-life, limiting its accumulation in tumors. This study introduces Tussah silk fibroin nanoparticles (TSF@ES-Cu NPs) to protect ES and Cu 2+ . TSF, with a stable structure, resists metabolism in circulation. Targeting tumors with natural RGD peptides and TSF's unique secondary structure, enhances drug enrichment and special release in pancreatic tumors, improving treatment efficacy. In vitro, TSF@ES-Cu induces tumor cell cuproptosis, releases DAMPs, promotes dendritic cells (DCs) maturation, and macrophage M1 polarization. In vivo, TSF@ES-Cu reshapes the tumor microenvironment (TME), increasing mature DCs from 22.7% to 43.3%, CD8 + T cells from 5.08% to 17.1%, and reducing M2 macrophages from 50.7% to 18.4%. Additionally, the combined anti-tumor efficacy of TSF@ES-Cu and αPDL-1 is 1.6 times higher than TSF@ES-Cu alone and 2.5 times higher than αPDL-1 alone. In summary, this study reports that the combination of TSF@ES-Cu and αPDL-1 effectively induces cuproptosis and reshapes the TME, offering a new approach for copper nanomaterial-based tumor immunotherapy.}, archive = {J_ADVS}, author = {Si Gao and Haodong Ge and Lili Gao and Ying Gao and Shuibin Tang and Yiming Li and Zhiqing Yuan and Wei Chen}, doi = {10.1002/advs.202417676}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2417676}, shortjournal = {Adv. Sci.}, title = {Silk fibroin nanoparticles for enhanced cuproptosis and immunotherapy in pancreatic cancer treatment}, volume = {12}, year = {2025}, }
• (2025). Hierarchical assembly of carbon dots with full-solar-spectrum absorption for solar energy applications. ADVS, 12(18), 2417457. (www)

  @article{ , abstract = {Carbon dots (CDs) featuring low-cost, non-toxic, and appealing optical properties demonstrate promising applications in energy, e.g. solar energy capture and conversion. However, it remains a significant challenge to expand the absorption bands of CDs from visible to near-infrared (NIR) spectral regions to harness the entire spectrum of sunlight for efficient solar energy utilization. Herein, hierarchical assemblies of CDs (HA-CDs) are constructed by stepwise assembling monodispersed ultraviolet-absorbing CDs to water-soluble visible-NIR absorbing supra-CDs (PA-CDs), and then complexing PA-CDs with Fe 3+ ions to form 3D porous architectures (HA-CDs) with full solar spectrum absorption and good water resistance. Notably, the HA-CDs exhibit good hydrophilicity and superior photothermal conversion efficiency of 84% under simulated solar irradiation. The facile Fe 3+ ion cross-linking assembly property enables the in situ preparation of HA-CDs on various fabric substrates, resulting in low-cost, high-performance photothermal conversion products. High-performance 2D solar-driven interfacial water evaporation, electricity generation, and water-electricity cogeneration have been demonstrated in the HA-CDs in situ coated fabric (HA-CDs-fabric). This study provides a novel and effective design approach for the development of high-performance CD-based photothermal materials for solar energy applications.}, archive = {J_ADVS}, author = {Lei Li and Di Li and Yanfei Qu and Ruoyu Zhang and Shuo Qi and Mengyao Liu and Haohao Bi and Tao Jia and Songnan Qu and Weitao Zheng}, doi = {10.1002/advs.202417457}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2417457}, shortjournal = {Adv. Sci.}, title = {Hierarchical assembly of carbon dots with full-solar-spectrum absorption for solar energy applications}, volume = {12}, year = {2025}, }
• (2025). Enhancing tendon regeneration: Investigating the impact of topography on the secretome of adipose-derived stem cells. ADVS, 12(18), 2417447. (www)

  @article{ , abstract = {Tendons are vital for maintaining integrity and movement, but current treatment options are insufficient for their regeneration after injuries. Previous studies have shown that the secretome from mesenchymal stem cells (MSCs) promoted tendon regeneration. However, limited studies have explored the impact of the physical microenvironment on the secretome's efficacy of MSCs. In this study, it is shown that the topographic orientation regulates the secretome of human adipose-derived stem cells (ADSCs) and promotes tendon regeneration. Conditioned medium (CM) is collected from ADSCs cultured on the scaffolds with different topography. The results show that CM generated from aligned structure group has a potent effect in promoting cell migration and proliferation, tenogenic differentiation, macrophage polarization toward M2 phenotype, tendon structure and mechanical function recovery. Proteomic analysis revealed that the aligned structure can up-regulate the secretion of Extracellular matrix (ECM) proteins while down-regulate proinflammatory factors. This modulation activates the MAPK, GPCR and Integrin signaling pathways which may account for the enhanced effect on tendon regeneration. This study offers a promising and safer non-cell-based treatment option for tendon repair.}, archive = {J_ADVS}, author = {Qiuzi Long and Chuanquan Liu and Haotian Zheng and Mingyue Wang and Hanmei Liu and Yue Liu and Zhicheng Cao and Yuzhi Sun and Qingyun Mo and Ludvig J. Backman and Jialin Zhu and Lizhi Hu and Jinlong Huang and Wei Zhang and Jialin Chen}, doi = {10.1002/advs.202417447}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2417447}, shortjournal = {Adv. Sci.}, title = {Enhancing tendon regeneration: Investigating the impact of topography on the secretome of adipose-derived stem cells}, volume = {12}, year = {2025}, }
• (2025). High-entropy non-flammable ionic Liquid/Dimethoxymethane composite electrolyte for high-performance lithium-ion batteries. ADVS, 12(18), 2417306. (www)

  @article{ , abstract = {The development of high-energy-density and high-safety lithium-ion batteries requires advancements in electrolytes. This study proposes a high-entropy ionic liquid/ether composite electrolyte, which is composed of N -propyl- N -methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PMP–TFSI) ionic liquid, dimethoxymethane (DME), lithium difluoro(oxalato)borate (LiDFOB), fluoroethylene carbonate (FEC), and 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (TTE). In this electrolyte, a unique coordination structure forms, where Li + is surrounded by a highly complex environment consisting of DME, FEC, TTE, TFSI − , DFOB − , and PMP + . The effects of this solution structure on the solid-electrolyte interphase chemistry and Li + desolvation kinetics are examined. The proposed electrolyte has low flammability, high thermal stability, negligible corrosivity toward an Al current collector, and the ability to withstand a high potential of up to 5 V. Importantly, this electrolyte is highly compatible with graphite and SiO x anodes, as well as a high-nickel LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathode. Operando X-ray diffraction data confirm that the co-intercalation of DME and PMP + into the graphite lattice, a long-standing challenge, is eliminated with this electrolyte. A 4.5-V LiNi 0.8 Co 0.1 Mn 0.1 O 2 //graphite full cell with the proposed high-entropy electrolyte is shown to have superior specific capacity, rate capability, and cycling stability, demonstrating the great potential of the proposed electrolyte for practical applications.}, archive = {J_ADVS}, author = {Purna Chandra Rath and Chun-Yen Chen and Jagabandhu Patra and Chun-Chen Yang and Yu-Sheng Su and Chien-Te Hsieh and Wei-Ren Liu and Ju Li and Jeng-Kuei Chang}, doi = {10.1002/advs.202417306}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2417306}, shortjournal = {Adv. Sci.}, title = {High-entropy non-flammable ionic Liquid/Dimethoxymethane composite electrolyte for high-performance lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Molecular regulation and intermolecular chemistry in gel polymer electrolytes for high-voltage lithium batteries. ADVS, 12(18), 2417169. (www)

  @article{ , abstract = {Gel polymer electrolyte (GPE) has garnered widespread attention in the field of lithium batteries because of its low interfacial impedance, high thermal stability, and flexibility. However, the high-voltage compatibility and Li + transport kinetics of GPE have yet to meet the requirements of future high-energy secondary battery systems. In this regard, a comprehensive and insightful review of high-voltage lithium batteries with GPE has attracted significant attention, focusing on molecular design and intermolecular interactions. Molecular regulation involves customizing the polymer matrix, solvent, additive, and Li salt, while intermolecular interactions encompass hydrogen bond interactions, Lewis acid-base interactions, electrostatic interactions, and π–π stacking interactions. Besides, strategies to enhance the stability of the cathode electrolyte interphase and Li + transport kinetics are summarized. It is hoped that this review will provide a deeper understanding of the direct regulation of GPE at the molecular level, further accelerating the commercialization of GPE in high-energy secondary lithium batteries.}, archive = {J_ADVS}, author = {Qingjie Zhou and Mengxue He and Shuyang Gao and Wangshu Hou and Yulin Ma and Hua Huo and Chunyu Du and Geping Yin and Pengjian Zuo}, doi = {10.1002/advs.202417169}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2417169}, shortjournal = {Adv. Sci.}, title = {Molecular regulation and intermolecular chemistry in gel polymer electrolytes for high-voltage lithium batteries}, volume = {12}, year = {2025}, }
• (2025). An intracellular peptide library screening platform identifies irreversible covalent transcription factor inhibitors. ADVS, 12(18), 2416963. (www)

  @article{ , abstract = {The development of an intracellular peptide library screening platform is described to identify covalent transcription factor (TF) antagonists. The Transcription Block Survival (TBS) assay and subsequent hit refinement previously produced potent but reversible antagonists of the oncogenic TF cJun. TBS moves beyond a target binding readout to ensure loss of TF function by blocking TF-DNA binding. Here, the TBS methodology is significantly expanded to identify covalent and highly selective inhibitors. A 131,072-member library is probed containing a Cys option at nine positions within a non-reducing cell line. This identified a single Cys residue with the appropriate geometry for disulphide bond formation with cJun C269 in its DNA binding domain. The selection of a unique Cys in the antagonist indicates both target shutdown and concomitant disulphide formation in a single step, resulting in increased potency. Substituting Cys with an electrophile generates an irreversible yet highly selective covalent cJun inhibitor capable of penetrating human melanoma cells in culture and depleting oncogenic cJun levels to inhibit cell viability, with enhanced efficacy compared to a previous cJun-targeting peptide. This enhanced covalent-TBS screening pipeline provides a robust approach to profile target protein surfaces for ligandable cysteines, producing covalent and selective antagonists with appropriately positioned warheads.}, archive = {J_ADVS}, author = {Andrew Brennan and Scott Lovell and Keith W Vance and Jody M Mason}, doi = {10.1002/advs.202416963}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416963}, shortjournal = {Adv. Sci.}, title = {An intracellular peptide library screening platform identifies irreversible covalent transcription factor inhibitors}, volume = {12}, year = {2025}, }
• (2025). Pupil-adaptive retina projection augment reality displays with switchable ultra-dense viewpoints. ADVS, 12(18), 2416961. (www)

  @article{ , abstract = {Multi-viewpoint retina projection displays (RPD) with an expanded visible range have been utilized in recent augmented reality (AR) systems to address the vergence-accommodation conflict (VAC) by providing a long depth of field (DOF). However, these fixed multi-viewpoint RPD systems still face a common critical challenge of imaging overlap or discontinuity when eyes rotate or under varying ambient light. To address this, an RPD AR system featuring switchable ultra-dense viewpoints is presented, enabled by a photo-alignment liquid crystal Dammann grating (p-LCDG). The number of viewpoints reaches 49, which forms an ultra-high density of diffraction lattice in front of the pupil with a record high rotation precision of 1.28°/viewpoint, allowing for a substantial range of 36 mm 2 . More importantly, the spacing of adjacent viewpoints is 0.532 mm, much smaller than the minimum radius of the pupil (≈1 mm). To facilitate viewpoint switching, a light selector is implemented, ensuring that only the light from a specific viewpoint reaches the eye, which effectively eliminates the image missing or discontinuity. By combining eye tracking technology, the viewer can consistently perceive a singular and clear image from the proposed RPD system, achieving seamless switching of viewpoints. This innovative design paves the way for high-performance RPDs in AR applications.}, archive = {J_ADVS}, author = {Haonan Jiang and Yuechu Cheng and Zhibo Sun and Zhengnan Yuan and Huajian Jin and Yipeng Huo and Man-Chun Tseng and Fion Yeung and Hoi-Sing Kwok and Enguo Chen}, doi = {10.1002/advs.202416961}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416961}, shortjournal = {Adv. Sci.}, title = {Pupil-adaptive retina projection augment reality displays with switchable ultra-dense viewpoints}, volume = {12}, year = {2025}, }
• (2025). Three-state thermochromic smart window for building energy-saving. ADVS, 12(18), 2416688. (www)

  @article{ , abstract = {Smart windows that dynamically regulate solar spectrum transmission to reduce energy consumption in heating, ventilation, and air conditioning systems are highly desirable. However, the limited amplitude of the regulation and narrow wavelength control often degrade the modulation performance of existing smart windows. To improve solar modulation and thermal management, here we propose a three-state thermochromic smart window (TSSW) capable of modulation across the entire solar spectrum. The TSSW is mainly based on the unique phase transition properties of tungsten-doped vanadium dioxide (W-VO₂) and perovskite films, which can stepwise control the visible light and near-infrared (NIR) transmittance separately, leading to the adaptive transitions between cold, warm, and hot states. Results indicate that the TSSW achieves a solar modulation rate of 23.5%, with indoor solar irradiance decreasing from 413.6 W/m 2 in the cold state to 374.5 W/m 2 in the warm state, and down to 189.1 W/m 2 in the hot state. The simulation results show that the annual total energy demand can be reduced by up to 102.09 WJ/m 2 in some typical regions. Compared to Low-E glass and ordinary glass, this TSSW offers superior energy-saving potential, making it an ideal solution for reducing building energy consumption.}, archive = {J_ADVS}, author = {Meiling Liu and Xiansheng Li and Wenshuo Zhang and Lanxin Li and Liang Li and Chengming Wang and Gang Pei and Bin Zhao and Chongwen Zou}, doi = {10.1002/advs.202416688}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416688}, shortjournal = {Adv. Sci.}, title = {Three-state thermochromic smart window for building energy-saving}, volume = {12}, year = {2025}, }
• (2025). Suspended lithium nitrate-based electrolytes: Electrostatic interactions for mutually rewarding interface optimization strategies. ADVS, 12(18), 2416656. (www)

  @article{ , abstract = {Designing a stable electrode-electrolyte interface (EEI) is critical for developing lithium metal batteries with high energy density, enhanced safety, and broad applicability. Lithium nitrate (LiNO 3 ) is an attractive sacrificial additive for lithium metal anode, while its poor solubility in high-voltage-resistant ester/nitrile electrolytes severely limits its utility. To solve it, a novel suspension electrolyte strategy is proposed that uniformly disperses LiNO 3 particles in an ester/nitrile mixed electrolyte to stabilize the electrode interface. The suspended LiNO 3 particles exhibit dual functionality: LiNO 3 enhances the compatibility between the electrode and the electrolyte by affecting the Li + solvation environment and preferentially adsorb on the electrode surface; moreover, the in situ formed LiN x O y -rich EEI by LiNO 3 decomposition with accelerated Li⁺ transport kinetics, effectively suppresses parasitic reactions and improves rate performance. The optimized electrolyte makes Li||NCM523 battery run stably for 100 cycles with a high capacity retention of 90.05% at 60 °C and stably operated at low temperature (-10 °C). Moreover, the electrolyte shows excellent electrochemical stability at a high-voltage of 4.5 V. This work presents a dual-strategy advancement featuring wide-temperature electrolyte formulation and precision interface engineering, synergistically achieving high-specific-energy lithium metal batteries.}, archive = {J_ADVS}, author = {Wenjing Zhang and Zhenguo Zhang and Hongtao Zhang and Yang Luo and Xinjian Liu and Zhonghao Rao}, doi = {10.1002/advs.202416656}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416656}, shortjournal = {Adv. Sci.}, title = {Suspended lithium nitrate-based electrolytes: Electrostatic interactions for mutually rewarding interface optimization strategies}, volume = {12}, year = {2025}, }
• (2025). Precise control of lead halide and ammonium salt stoichiometric ratios for efficient perovskite solar cells. ADVS, 12(18), 2416634. (www)

  @article{ , abstract = {The precise stoichiometric ratio of lead halide and organic ammonium salts is a fundamental yet unresolved scientific challenge in perovskite solar cells (PSCs). Conventional deposition techniques fail to establish a definitive structure-performance relationship due to limitations in quantitative control, leading to inconsistent film quality and ambiguous reaction pathways. In this work, a precise quantitative deposition approach using drop-on-demand inkjet printing to systematically investigate the impact of organic salt deposition surface density on PSC performance is developed. The findings reveal that the deposition amount significantly affects the morphology, composition, and crystallinity of the perovskite films, influencing the overall device performance. Low deposition surface densities below 22 µg cm −2 produce thin perovskite films with incomplete crystallization and small crystals, hindering charge carrier transport and separation. Conversely, a high deposition density (89 µg cm −2 ) results in over-reaction between the organic salt and PbI 2 , leading to low-quality perovskite films with pinholes, cracks, and poor interfacial contact. At the optimal deposition density of 39 µg cm −2 , it achieves high-quality perovskite films with large grains, reduced defects, and improved energy level alignment, resulting in a champion efficiency of 23.3% and improved environmental stability for the devices.}, archive = {J_ADVS}, author = {Hengyi Jiang and Rui Yang and Ziqi Zhu and Chao Sun and Yongbin Jin and Lingfang Zheng and Lina Shen and Chengbo Tian and Liqiang Xie and Jinxin Yang and Zhanhua Wei}, doi = {10.1002/advs.202416634}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416634}, shortjournal = {Adv. Sci.}, title = {Precise control of lead halide and ammonium salt stoichiometric ratios for efficient perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). A rapid cortical learning process supporting students’ knowledge construction during real classroom teaching. ADVS, 12(18), 2416610. (www)

  @article{ , abstract = {Classroom teaching is essential for cognitive development and cultural evolution, yet its neurocognitive mechanisms remain unclear. Here, this is explored in a university graduate course by combining wearable functional near-infrared spectroscopy (fNIRS) and machine learning models. The results show that blended teaching involving both students’ recalling and teachers’ lecturing leads to better learning outcomes than lecturing alone. Moreover, during the same lecturing phase, blended teaching induces knowledge construction in the middle frontal cortex (MFC), while lecturing alone induces knowledge representation in the right temporoparietal junction (TPJ), with the former significantly correlating with the final learning outcomes. Additionally, the MFC's construction begins during earlier recalling but is significantly facilitated by later lecturing. Finally, when teacher's TPJ activity precedes that of students’ MFC, significant teacher–student neural synchronization is observed during lecturing of blended teaching and is correlated with learning outcomes. These findings suggest that, in the real classroom teaching, the MFC serves as a hub of a rapid cortical learning process, supporting knowledge construction through a projection from the teacher's TPJ.}, archive = {J_ADVS}, author = {Xiaodan Feng and Xinran Xu and Zhaonan Meng and Jiahao Jiang and Miao Pei and Yonghe Zheng and Chunming Lu}, doi = {10.1002/advs.202416610}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416610}, shortjournal = {Adv. Sci.}, title = {A rapid cortical learning process supporting students’ knowledge construction during real classroom teaching}, volume = {12}, year = {2025}, }
• (2025). Mechanically robust mesoporous UiO-66-NH2/Nanofibrous aerogel for organophosphonates detoxification. ADVS, 12(18), 2416540. (www)

  @article{ , abstract = {There is a critical need for novel composite materials for high-performance chemical filtration and detoxification of organophosphonates (OPs) and other harmful compounds found in nerve agents, pesticides, and industrial processes. In this work, rapid hydrolysis of OPs using high-surface-area zirconium-based MOF-aerogel composites is demonstrated. Using a unique surfactant-templated solvothermal synthesis method, mesoporous UiO-66-NH 2 grown on the fibers within a polyacrylonitrile (PAN)/polyvinylpyrrolidone (PVP) nanofibrous sponge can produce a 3D MOF–polymer matrix with a specific surface area of up to 900 m 2 g −1 comp —almost 2X larger than the highest previously reported values while maintaining robust mechanical integrity. The mesoporous MOF promotes efficient diffusion, and the aerogel matrix provides a high-surface-area platform for spill containment. Unlike activated carbon, which adsorb OPs without degradation, the UiO-66-NH 2 -sponges hydrolyze OPs upon water contact, significantly reducing their toxicity. The MOF-aerogel sponges withstand stresses up to 40 kPa under 70% strain are shown while maintaining exceptional catalytic efficiency, achieving a methyl paraoxon degradation half-life of 3 min, compared to 15 min for similar microporous MOFs. This innovation accentuates the potential of mesoporous Zr-MOF aerogels for advanced protection, filtration, and catalysis.}, archive = {J_ADVS}, author = {Mai O. Abdelmigeed and Muhammed Ziauddin Ahmad Ebrahim and Vahid Rahmanian and John J. Mahle and Gregory W. Peterson and Saad A. Khan and Gregory N. Parsons}, doi = {10.1002/advs.202416540}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416540}, shortjournal = {Adv. Sci.}, title = {Mechanically robust mesoporous UiO-66-NH2/Nanofibrous aerogel for organophosphonates detoxification}, volume = {12}, year = {2025}, }
• (2025). Multifunctional conductive nanofibers for self-powered glucose biosensors. ADVS, 12(18), 2416320. (www)

  @article{ , abstract = {Electrochemical glucose biosensors are essential for diabetes management, and self-powered systems present an eco-friendly and innovative alternative. Traditional biosensors face several limitations including limited sensitivity, enzyme instability, and dependency on external power sources. Addressing these issues, the study develops a novel multifunctional nanofiber integrating biosensor for glucose detection and a self-powered motion sensor, utilizing an innovative triboelectric nanogenerator (TENG) system. Electrospun nanofibers, composed of graphene oxide (GO), porous graphene (PG), graphene foam (GF), polypyrrole (PPy), and polycaprolactone (PCL), demonstrate enhanced electrical conductivity, triboelectric efficiency, and mechanical strength. Among these, dip-coated nanofibers exhibited the highest conductivity of 4.9 × 10⁻⁵ S/cm, attributed to superior surface electrical properties of GO. PCL/PPy/GO nanofibers achieved the highest glucose detection performance in cyclic voltammetry and differential pulse voltammetry due to efficient electron transfer mechanisms of GO and PPy. Additionally, triboelectric tests revealed peak voltages of 63V with PCL/PPy/GO and polyvinylidene fluoride nanofibers containing glucose oxidase enzyme. Core-sheath and dip-coated nanofibers also demonstrated significant mechanical resilience (∼0.9 N force, ∼350 s durability). These findings highlight PCL/PPy/GO nanofibers as a multifunctional, efficient, and scalable solution, offering highly sensitive glucose detection and non-invasive sweat analysis along with robust energy harvesting for environmentally friendly and advanced diabetes management systems.}, archive = {J_ADVS}, author = {Seda Gungordu Er and Rameesh Bulathsinghala and Selvinaz Burcu Kizilates and Bing Li and Rucchi Ryan and Tanveer A. Tabish and Ishara Dharmasena and Mohan Edirisinghe}, doi = {10.1002/advs.202416320}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416320}, shortjournal = {Adv. Sci.}, title = {Multifunctional conductive nanofibers for self-powered glucose biosensors}, volume = {12}, year = {2025}, }
• (2025). Electroactive electrospun nanofibrous scaffolds: Innovative approaches for improved skin wound healing. ADVS, 12(18), 2416267. (www)

  @article{ , abstract = {The incidence and burden of skin wounds, especially chronic and complex wounds, have a profound impact on healthcare. Effective wound healing strategies require a multidisciplinary approach, and advances in materials science and bioengineering have paved the way for the development of novel wound healing dressing. In this context, electrospun nanofibers can mimic the architecture of the natural extracellular matrix and provide new opportunities for wound healing. Inspired by the bioelectric phenomena in the human body, electrospun nanofibrous scaffolds with electroactive characteristics are gaining widespread attention and gradually emerging. To this end, this review first summarizes the basic process of wound healing, the causes of chronic wounds, and the current status of clinical treatment, highlighting the urgency and importance of wound dressings. Then, the biological effects of electric fields, the preparation materials, and manufacturing techniques of electroactive electrospun nanofibrous (EEN) scaffolds are discussed. The latest progress of EEN scaffolds in enhancing skin wound healing is systematically reviewed, mainly including treatment and monitoring. Finally, the importance of EEN scaffold strategies to enhance wound healing is emphasized, and the challenges and prospects of EEN scaffolds are summarized.}, archive = {J_ADVS}, author = {Yang Zhang and Zhiyuan Zheng and Shilu Zhu and Liang Xu and Qingdong Zhang and Jie Gao and Min Ye and Shuwei Shen and Jinyu Xing and Ming Wu and Ronald X. Xu}, doi = {10.1002/advs.202416267}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416267}, shortjournal = {Adv. Sci.}, title = {Electroactive electrospun nanofibrous scaffolds: Innovative approaches for improved skin wound healing}, volume = {12}, year = {2025}, }
• (2025). High-performance polymer-derived ceramics in LCD 3D printing. ADVS, 12(18), 2416176. (www)

  @article{ , abstract = {This study demonstrates the fabrication of high-strength, lightweight polymer-derived ceramics (PDCs) using silicon oxycarbide (SiOC)-precursor formulations with liquid crystal display (LCD) vat photopolymerization (VPP) technology. Complex geometries, such as gyroids and stochastic lattices, are successfully 3D-printed and evaluated under varying feature thicknesses and pyrolysis temperatures (800 °C and 1200 °C). Photorheology and thermogravimetric analysis (TGA) validated the efficient curing and pyrolysis characteristics of a printable precursor formulation based on vinyl methoxysiloxane homopolymer (VMM-010), which demonstrated rapid curing, low viscosity, and compatibility with LCD 3D printing, ensuring precise layering and efficient resin removal. Micro-CT scans confirmed its structural integrity and absence of voids, even in relatively thick components (≈3 mm). The VMM-based PDC lattices achieved specific compressive strengths up to 9.4 MPa g⁻¹ cm 3 , a 50-fold improvement over comparable lattices produced with a high-porosity SiOC PDC, and exceptional high-temperature stability, maintaining structural integrity after 2 h at 1500 °C. Compositional analysis revealed lower free carbon content and improved ceramic phase formation, driving the enhanced mechanical and thermal performance of the VMM-based ceramic. These findings underscore the scalability, reliability, and superior performance of VMM formulations for LCD 3D printing, offering new possibilities for high-performance ceramic applications in aerospace, automotive, and biomedical industries.}, archive = {J_ADVS}, author = {H. Yazdani Sarvestani and V. Karamzadeh and A. Kulkarni and A. Sohrabi-Kashani and T. Lacelle and M.B. Jakubinek and B. Ashrafi}, doi = {10.1002/advs.202416176}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416176}, shortjournal = {Adv. Sci.}, title = {High-performance polymer-derived ceramics in LCD 3D printing}, volume = {12}, year = {2025}, }
• (2025). Broadband, wide-angle, and versatile metasurface illusions with inverse synthetic aperture radar imaging. ADVS, 12(18), 2416172. (www)

  @article{ , abstract = {Generation of controllable illusions has raised widespread interest. Over the past few decades, this field has been revolutionized by the emergence of metamaterials and metasurfaces. However, current efforts utilizing single-layer metasurfaces are limited to simple illusion demonstrations by reproducing electromagnetic field distributions, which also struggle to achieve both broad bandwidths and wide angular ranges. Here, a nontrivial multi-layer illusion strategy is proposed utilizing the inverse synthetic aperture radar imaging. The customization of illusions is facilitated by correlating the phase dispersion of meta-atoms within the target frequency interval with the positioning of the structure. The approach enables the creation of illusions across a broadband of 8 to 12 GHz and a wide angular range from −30° to 30°. As a proof of principle, several illusions are experimentally demonstrated, showcasing the diversity of the approach. This work presents a viable illusion strategy that is more feasible for practical applications in the microwave domain, paving the way for future advances of customizable illusions.}, archive = {J_ADVS}, author = {Haoran Li and Kang Luo and Din Ping Tsai and Yulang Li and Linyuan Dou and Shuqiao Li and Tao He and Yuancheng Fan and Mu Ku Chen and Zhanshan Wang and Yuzhi Shi and Zeyong Wei and Xinbin Cheng}, doi = {10.1002/advs.202416172}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416172}, shortjournal = {Adv. Sci.}, title = {Broadband, wide-angle, and versatile metasurface illusions with inverse synthetic aperture radar imaging}, volume = {12}, year = {2025}, }
• (2025). Li+ diffusion in LinCoNb2O6 (0 < n ≤ 6) anode with high capacity density: Fast kinetics and mechanistic insights. ADVS, 12(18), 2416001. (www)

  @article{ , abstract = {The potential of high power/capacity density and Li + solid diffusion mechanisms of niobium-based binary metal oxide (CoNb 2 O 6 ) anode material are investigated by combining high-rate Nb 2 O 5 with the redox-active 3d transition metal Co. CoNb 2 O 6 exhibited exceptional rate capability and cycling stability, which is attributed to anisotropic expansion during cycling and dual diffusion mechanisms at high and low lithium concentrations. The anisotropic expansion of crystals ensures structural stability, whereas the organic combination of a direct-hopping diffusion mechanism in Li n CoNb 2 O 6 (0 ≤ n ≤ 3) and a knock-off diffusion mechanism in Li n CoNb 2 O 6 (3 < n ≤ 6) based on the nudged elastic band (NEB) calculations reveals rapid Li + solid diffusion and excellent rate performance during lithiation/delithiation. The electrochemical performance of CoNb 2 O 6 also depends on its morphology, where different structures modulate synergistic Nb and Co interactions, influencing Li + diffusion in the Nb layers. Specifically, the micron-scale structure formed by secondary particle attachment (CoNb 2 O 6 -MP) provides space for anisotropic expansion, fully utilizing the dual ion diffusion mechanism, enhancing diffusion efficiency, and delivering both high-capacity density and excellent rate performance. This work not only introduces CoNb 2 O 6 with superior electrochemical properties but also provides insights into the solid diffusion mechanisms under various lithium concentrations, offering a foundation for designing electrode materials with enhanced ion diffusion pathways.}, archive = {J_ADVS}, author = {Yimo Xiang and Shaowen Tan and Jingxian Yu and Shengping Wang}, doi = {10.1002/advs.202416001}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2416001}, shortjournal = {Adv. Sci.}, title = {Li+ diffusion in LinCoNb2O6 (0 < n ≤ 6) anode with high capacity density: Fast kinetics and mechanistic insights}, volume = {12}, year = {2025}, }
• (2025). A new strategy to functionalize exosomes via enzymatic engineering of surface glycans and its application to profile exosomal glycans and endocytosis. ADVS, 12(18), 2415942. (www)

  @article{ , abstract = {Exosomes are membrane-enclosed nanoparticles secreted by cells to mediate intercellular communication. Hence, functionalized exosomes are powerful tools in biology and medicine, and efficient methods to functionalize exosomes are highly desired. In this work, a novel approach is developed to modify and functionalize exosomes based on enzymatic engineering of their surface glycans. It employs a sialyltransferase and an azide-modified sialyl donor to enzymatically install azido-sialic acids onto exosomal glycans. The azide tags serve as universal molecular handles to attach various probes, e.g., biotin, protein, fluorophore, etc., by simple and biocompatible click chemistry. This approach is easy and effective, and the modified exosomes are readily retrieved from the plate, enabling the production of functional exosomes in practical scales for various studies and applications. The functionalized exosomes obtained are employed to profile exosomal glycans, disclosing the diverse glycosylation patterns of exosomes of different origins. They also facilitated comprehensive investigations on the cellular uptake of exosomes to disclose macropinocytosis as the main and general uptake route, while other endocytosis pathways are also partially involved in specific exosomes. Additionally, the new exosome functionalization approach has been demonstrated to be widely applicable to exosomes of different origins.}, archive = {J_ADVS}, author = {Sayan Kundu and Jiatong Guo and Md. Shamiul Islam and Rajendra Rohokale and Mohit Jaiswal and Zhongwu Guo}, doi = {10.1002/advs.202415942}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2415942}, shortjournal = {Adv. Sci.}, title = {A new strategy to functionalize exosomes via enzymatic engineering of surface glycans and its application to profile exosomal glycans and endocytosis}, volume = {12}, year = {2025}, }
• (2025). Manipulation of antiferromagnetic metal phase in nd1-xCexNiO3 by epitaxial strain. ADVS, 12(18), 2415785. (www)

  @article{ , abstract = {Antiferromagnetic metals (AFMs) are potential candidates for spintronics application owing to their insensitivity to external magnetic perturbations. However, the scarcity of AFM in complex oxide presents a significant challenge in tuning their critical properties, thereby impeding the exploration of emergent phenomena and the advancement of practical applications. Quite recently, an AFM ground state is discovered in Nd 1-x Ce x NiO 3 , an oxide whose undoped parent counterpart exhibits metal-insulator transition dependent on temperature. Herein, the engineering of the AFM state by epitaxial strain in Nd 1-x Ce x NiO 3 (0 ≤ x ≤ 0.07) films is demonstrated, where both Néel temperature and the metal–metal transition temperature exhibit significant response. Particularly in the 5% Ce-doping counterpart (Nd 0.95 Ce 0.05 NiO 3 ), a suppression of the structural transition driven by compression strain causes a transition of the electronic/magnetic ground state from the AFM to paramagnetic metal. The O-K edge X-ray absorption spectra (XAS) reveal that strain plays a crucial role in modulating the magnetic ground state through modifying Ni─O hybridization. This work demonstrates the successful engineering of the electronic/magnetic states of AFM through epitaxial strain, providing a vital roadmap for the development of nickelate-based AFM devices.}, archive = {J_ADVS}, author = {Zhan Yang and Junhua Liu and Wen Xiao and Shilin Hu and Zhixiong Deng and Xuedong Bai and Lei liao and Yulin Gan and Kai Chen and Lifen Wang and Zhaoliang Liao and Haizhong Guo}, doi = {10.1002/advs.202415785}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2415785}, shortjournal = {Adv. Sci.}, title = {Manipulation of antiferromagnetic metal phase in nd1-xCexNiO3 by epitaxial strain}, volume = {12}, year = {2025}, }
• (2025). PLXDC1+ tumor-associated pancreatic stellate cells promote desmoplastic and immunosuppressive niche in pancreatic ductal adenocarcinoma. ADVS, 12(18), 2415756. (www)

  @article{ , abstract = {Pancreatic stellate cells (PSCs) contribute to pancreatic ductal adenocarcinoma (PDAC) progression and therapeutic resistance, yet their detailed functions remain unclear. This study combined RNA sequencing and assay for transposase-accessible chromatin using sequencing (ATAC-seq) on sorted PSCs from adjacent normal and PDAC tissues to investigate their transcriptional and epigenetic activation. PSCs heterogeneity and functions are characterized through bulk, single-cell, and spatial transcriptomes, as well as in situ sequencing. The clinical relevance of PSCs in immunotherapy is assessed using an in-house immune-checkpoint blockade (ICB) treatment cohort. Findings showed that stress and hypoxia signaling activated PSCs in PDAC. Three common PSCs (CPSCs) and four tumor-associated PSCs (TPSCs) are identified, each with distinct functions. CPSCs differentiated into CCL19 + TPSCs in immune-enriched regions, MYH11 + TPSCs in the stromal region, and PLXDC1 + TPSCs, which exhibited cancer-associated myofibroblasts (myCAFs) phenotype linked to poor prognosis. Notably, PLXDC1 + TPSCs, located near aggressive LRRC15 + myCAFs and SPP1 + macrophages, formed a desmoplastic and immunosuppressive niche around the tumor boundary, promoting CD8 T cell exhaustion. Single-cell transcriptomics of PDAC patients treated with ICB revealed that PLXDC1 + TPSCs correlated with poor immunotherapy efficacy. Overall, this study provides key insights into PSCs in PDAC and potential therapeutic targets.}, archive = {J_ADVS}, author = {Yanhua Du and Yizhou Zhao and Judong Li and Jiaxin Wang and Shenglan You and Yao Zhang and Li Zhang and Jihong Yang and Hamid Alinejad-Rokny and Shujie Cheng and Chenghao Shao and Duowu Zou and Youqiong Ye}, doi = {10.1002/advs.202415756}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2415756}, shortjournal = {Adv. Sci.}, title = {PLXDC1+ tumor-associated pancreatic stellate cells promote desmoplastic and immunosuppressive niche in pancreatic ductal adenocarcinoma}, volume = {12}, year = {2025}, }
• (2025). Homocysteine promotes the pathogenesis of atherosclerosis through the circ-PIAS1-5/miR-219a-2-3p/TEAD1 axis. ADVS, 12(18), 2415563. (www)

  @article{ , abstract = {Previous studies have established a possible link between hyperhomocysteinemia (HHcy) and dyslipidemia. Circular RNAs (circRNAs) play important regulatory roles in the development of atherosclerosis. However, the biological functions and potential molecular mechanisms of circRNAs in HHcy-induced lipid accumulation leading to atherosclerosis are still unclear. In this study, it is determined that homocysteine (Hcy) downregulates the expression of circ-PIAS1-5 by global circRNA expression profiling and that circ-PIAS1-5 inhibits Hcy-mediated lipid accumulation in foam cells and the pathogenesis of atherosclerosis by acting as a sponge for miR-219a-2-3p. Circ-PIAS1-5 is identified as a potential diagnostic biomarker of HHcy-associated atherosclerosis in male “apolipoprotein E knockout (ApoE −/− )” mice. Mechanistically, circ-PIAS1-5 activates the adenosine 5‘-monophosphate (AMP)-activated protein kinase pathway by regulating TEAD1 through miR-219a-2-3p, and Hcy mediates the m 6 A modification and nuclear export of circ-PIAS1-5 via YTHDC1 to increase lipid accumulation in foam cells and accelerate the pathogenesis of atherosclerosis. Taken together, these results highlight the role of circ-PIAS1-5 in the Hcy-mediated pathogenesis of atherosclerosis and suggest its potential application as a prognostic biomarker of atherosclerosis induced by HHcy.}, archive = {J_ADVS}, author = {Shengchao Ma and Fei Ma and Ning Ding and Lin Xie and Anning Yang and Jiangyong Shen and Yun jiao and Kai Wu and YueE Chai and Zhigang Bai and Jiantuan Xiong and Nan Li and Huiping Zhang and Yideng Jiang}, doi = {10.1002/advs.202415563}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2415563}, shortjournal = {Adv. Sci.}, title = {Homocysteine promotes the pathogenesis of atherosclerosis through the circ-PIAS1-5/miR-219a-2-3p/TEAD1 axis}, volume = {12}, year = {2025}, }
• (2025). Hierarchical regulatory networks reveal conserved drivers of plant drought response at the cell-type level. ADVS, 12(18), 2415106. (www)

  @article{ , abstract = {Drought is a critical environmental challenge affecting plant growth and productivity. Understanding the regulatory networks governing drought response at the cellular level remains an open question. Here, a comprehensive multi-omics integration framework that combines transcriptomic, proteomic, epigenetic, and network-based analyses to delineate cell-type-specific regulatory networks involved in plant drought response is presented. By analyzing nearly 30 000 multi-omics data samples across species, unique insights are revealed into conserved drought responses and cell-type-specific regulatory dynamics, leveraging novel integrative analytical workflows. Notably, CIPK23 emerges as a conserved protein kinase mediating drought tolerance through interactions with CBL4 , as validated by yeast two-hybrid and BiFC assays. Experimental validation in Arabidopsis thaliana and Vitis vinifera confirms the functional conservation of CIPK23 , which enhances drought resistance in overexpression lines. In addition, the authors’ causal network analysis pinpoints critical regulatory drivers such as NLP7 and CIPK23 , providing insights into the molecular mechanisms of drought adaptation. These findings advance understanding of plant drought tolerance and offer potential targets for improving crop resilience across diverse species.}, archive = {J_ADVS}, author = {Moyang Liu and Yuanyuan Xu and Yue Song and Dongying Fan and Junpeng Li and Zhen Zhang and Lujia Wang and Juan He and Cheng Chen and Chao Ma}, doi = {10.1002/advs.202415106}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2415106}, shortjournal = {Adv. Sci.}, title = {Hierarchical regulatory networks reveal conserved drivers of plant drought response at the cell-type level}, volume = {12}, year = {2025}, }
• (2025). Semaphorin 3E–Plexin d1 axis drives lung fibrosis through ErbB2-mediated fibroblast activation. ADVS, 12(18), 2415007. (www)

  @article{ , abstract = {Idiopathic pulmonary fibrosis (IPF) is characterized by excessive fibroblast recruitment and persistent extracellular matrix deposition at sites of tissue injury, leading to severe morbidity and mortality. However, the precise mechanisms by which fibroblasts contribute to IPF pathogenesis remain poorly understood. The study reveals that Sema3E and its receptor Plexin D1 are significantly overexpressed in the lungs of IPF patients and bleomycin (BLM)-induced lung fibrotic mice. Elevated plasma levels of Sema3E in IPF patients are negatively correlated with lung function. Importantly, Sema3E in IPF lungs predominantly exists as the P61-Sema3E. The knockdown of Sema3E or Plexin D1 effectively inhibits fibroblast activation, proliferation, and migration. Mechanistically, Furin-mediated cleavage of P87-Sema3E into P61-Sema3E drives these pro-fibrotic activities, with P61-Sema3E-PlexinD1 axis promoting fibroblast activation, proliferation, and migration by affecting the phosphorylation of ErbB2, which subsequently activates the ErbB2 pathways. Additionally, Furin inhibition reduces fibroblast activity by decreasing P61-Sema3E production. In vivo, both whole-lung Sema3E knockdown and fibroblast-specific Sema3E knockout confer protection against BLM-induced lung fibrosis. These findings underscore the crucial role of the P61-Sema3E-Plexin D1 axis in IPF pathogenesis and suggest that targeting this pathway may hold promise for the development of novel therapeutic strategies for IPF treatment.}, archive = {J_ADVS}, author = {Zhesong Deng and Jinkun Chen and Ruonan Yang and Yuan Zhan and Shanshan Chen and Jiaheng Zhang and Hao Fu and Yiya Gu and Qian Huang and Jixing Wu and Lianyu Shan and Abdelilah Soussi Gounni and Jungang Xie}, doi = {10.1002/advs.202415007}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2415007}, shortjournal = {Adv. Sci.}, title = {Semaphorin 3E–Plexin d1 axis drives lung fibrosis through ErbB2-mediated fibroblast activation}, volume = {12}, year = {2025}, }
• (2025). Mitofusin 1 drives preimplantation development by enhancing chromatin incorporation of histone h3.3. ADVS, 12(18), 2414985. (www)

  @article{ , abstract = {Mitofusin 1 (MFN1) plays a crucial role in mitochondrial fusion and oocyte development. However, its function in preimplantation embryonic development and its potential involvement in epigenetic regulation remain poorly understood. In this study, it is shown that MFN1 interacts with PADI6, a key component of the cytoplasmic lattice in oocytes and early embryos. MFN1 deficiency in mice results in reduced PADI6 levels and decreased expression of translational machinery components, which suppress protein synthesis activity and lower histone H3.3 abundance. These disruptions lead to the failure of male pronucleus formation, aberrant zygotic genome activation, and impaired embryonic development. It is further demonstrated that the MFN1 activator S89 promotes H3.3 incorporation and rescues early development in maternally aged embryos with low MFN1 levels. Additionally, a positive correlation between MFN1 and H3.3 protein levels in early human embryos is observed. Together, these findings provide new insights into MFN1's role in regulating epigenetic reprogramming during preimplantation embryo development.}, archive = {J_ADVS}, author = {Xiao-yan Shi and Yu Tian and Yu-fan Wang and Yi-ran Zhang and Ying Yin and Qing Tian and Lei Li and Bing-xin Ma and Ximiao He and Li-quan Zhou}, doi = {10.1002/advs.202414985}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414985}, shortjournal = {Adv. Sci.}, title = {Mitofusin 1 drives preimplantation development by enhancing chromatin incorporation of histone h3.3}, volume = {12}, year = {2025}, }
• (2025). Reshape the fates of treg and CD8+T cells through IL-2Rα by synergizing divergent receptor-biased IL-2 PEGylates. ADVS, 12(18), 2414931. (www)

  @article{ , abstract = {Clinical trials of receptor-biased interleukin-2 (IL-2) variants in cancer therapy show limited efficacy. To investigate, we re-evaluated divergent receptor-biased IL-2 PEGylates (generated via site-specific PEGylation at residues D20 (not-β) and Y45 (not-α)), alone or in combination. Results showed the not-α variant (Y45) activates regulatory T cells (Tregs) via βγ chain binding, overriding CD8+ T cells and impairing efficacy. Conversely, the not-β IL-2 (D20) is inert alone but spatially blocks Y45’s βγ engagement, suppressing Treg activation. D20 also modulates activated CD8+ T cells by preferentially binding the α chain, disrupting Y45-mediated βγ signaling to prevent exhaustion and terminal differentiation. Synergy between these PEGylates highlights the α chain as a regulatory switch reshaping Treg, CD8+ T cell, and endothelial cell fates. In syngeneic tumor models, combined therapy enhanced CD8+ T cell infiltration, suppressed tumor growth, and reduced vascular leak syndrome risk. These findings propose combinatorial IL-2 strategies targeting α chain regulation to optimize antitumor responses.}, archive = {J_ADVS}, author = {Jiaqi Sun and Lingfeng Guo and Dezhong Ji and Mengfan Yu and Boyang Cheng and Xingxing Zhu and Yeshuang Yuan and Siyu Wu and Yuanjie Zhang and Wen Shi and Zhiqian Chen and Xindang Chu and Jiayu Hu and Liwen Hua and Yiming Wang and Yanning Zhu and Yu Mu and Hanwen Sun and Chuanling Zhang and Qi Wang and Sulong Xiao and Lihe Zhang and Bo Zhang and Demin Zhou}, doi = {10.1002/advs.202414931}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414931}, shortjournal = {Adv. Sci.}, title = {Reshape the fates of treg and CD8+T cells through IL-2Rα by synergizing divergent receptor-biased IL-2 PEGylates}, volume = {12}, year = {2025}, }
• (2025). Thermally reconstructed Ru/La-Co3O4 nanosheets with super thermal stability for catalytic combustion of light hydrocarbons: Induced surface LaRuO3 active phase. ADVS, 12(18), 2414919. (www)

  @article{ , abstract = {Addressing the thermal deactivation of catalysts remains critical for light hydrocarbons (LHs) combustion. This study develops Ru/La-Co 3 O 4 nanosheets combining RuO x and La-doped Co 3 O 4 , demonstrating exceptional high-temperature stability. The individual introduction of Ru or La significantly promoted the catalytic activity of Co 3 O 4 , but a severe thermal deactivation is still inevitable. Remarkably, the co-decoration of Ru and La brought a prominent resistance to high-temperature, the aged Ru/La-Co 3 O 4 at 750 °C for 4 h presented a better activity than the fresh catalyst and the T C3-90 instead decreased by 11 °C, even only increased by 1 °C after aging 100 h and 15 °C for 200 h. Systematic studies revealed that the co-presence of La and Ru enhanced the resistance to sintering of Co 3 O 4 and promoted the migration of the lattice oxygen, moreover, the high-temperature induced the formation of LaRuO 3 perovskite through the reaction of RuO x with the exsolved La from Co 3 O 4 . LaRuO 3 phase with excellent redox ability and thermal stability presented a superior activity for catalytic combustion of LHs and suppressed the leaching of Ru species in an oxidizing atmosphere at high temperature. This work contributed to the design of catalysts especially Ru based catalysts for the stable elimination of LHs emissions under high temperature conditions.}, archive = {J_ADVS}, author = {Biao Gao and Wei Deng and Hangqi Xia and Kai Shan and Li Wang and Boyuan Qiao and Qiang Niu and Aiyong Wang and Yun Guo and Wangcheng Zhan and Yanglong Guo and Qiguang Dai}, doi = {10.1002/advs.202414919}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414919}, shortjournal = {Adv. Sci.}, title = {Thermally reconstructed Ru/La-Co3O4 nanosheets with super thermal stability for catalytic combustion of light hydrocarbons: Induced surface LaRuO3 active phase}, volume = {12}, year = {2025}, }
• (2025). Antagonist targeting the species-specific fatty acid Dehydrogenase/Isomerase FabX for anti-h. pylori infection. ADVS, 12(18), 2414844. (www)

  @article{ , abstract = {Helicobacter pylori ( H. pylori ) is a group-1 definite pathogenic carcinogen that infects approximately half of the global population, yet no species-specific chemotherapy has yet been developed. It is previously discovered that H. pylori encodes an atypical dehydrogenase/isomerase FabX in the Type-II fatty acid biosynthesis pathway to produce unsaturated fatty acids (UFA) as well as superoxide (ROS). Here, it is demonstrated that FabX is essential for H. pylori growth and gastric colonization by retaining UFA synthesis and producing ROS, respectively, and is a species-specific anti- H. pylori drug target. The first small molecule inhibitor FBX-1991 against FabX, which inhibits the enzymatic activity with an IC 50 value of 0.158 × 10 −6 m in vitro, is developed. FBX-1991 binds inside the catalytic tunnel of FabX, disrupts the conformation of the key catalytic loop, and prevents the insertion of the acyl substrate for catalysis. Further in vivo studies suggest that FBX-1991 inhibits the H. pylori growth by partially inhibiting UFA synthesis and ROS excretion through targeting FabX. This study identifies a species-specific anti- H. pylori drug target, FabX, and discovers the first highly potent and selective FabX inhibitor against H. pylori infection, which provides the molecular basis for developing species-specific anti -H. pylori chemotherapy.}, archive = {J_ADVS}, author = {Lin Zhang and Xiaoxue Ruan and Xudong Hang and Ding Heng and Chang Cai and Liping Zeng and Guoxin Zhang and Lu Zhou and Hongkai Bi and Liang Zhang}, doi = {10.1002/advs.202414844}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414844}, shortjournal = {Adv. Sci.}, title = {Antagonist targeting the species-specific fatty acid Dehydrogenase/Isomerase FabX for anti-h. pylori infection}, volume = {12}, year = {2025}, }
• (2025). Minimizing energy loss by designing multifunctional solid additives to independent regulation of donor and acceptor layers for efficient LBL polymer solar cells. ADVS, 12(18), 2414712. (www)

  @article{ , abstract = {Solid additives are crucial in layer-by-layer (LBL) polymer solar cells (PSCs). Despite its importance, the simultaneous application of solid additives into both donor and acceptor layers has been largely overlooked. In this work, two multifunctional solid additives are actively designed, and investigated the synergistic effect on both donor and acceptor layers. Incorporating the multifunctional solid additives into the donor layer could effectively enhance the aggregation and molecular stacking of the donor polymer, leading to reduced energy disorder and minimizing Δ E 2 . When the multifunctional solid additives are introduced into the acceptor layer, they just play a role in optimizing the morphology, thereby reducing the Δ E 3 . Excitedly, the simultaneous addition of the multifunctional solid additives into both donor and acceptor layers produced a synergistic effect for decreasing Δ E 2 and Δ E 3 simultaneously, especially adding SA2, thus enabling an excellent power conversion efficiency (PCE) of 19.95% (certified as 19.68%) with an open-circuit voltage ( V oc ) of 0.921 V, a short circuit current density ( J sc ) of 27.08 mA cm −2 and a fill factor (FF) of 79.98%. The work highlights the potential of multifunctional solid additives in independently regulating the properties of donor and acceptor layers, which is expected as a promising approach for further developing higher performance PSCs.}, archive = {J_ADVS}, author = {Junying Wang and Min Deng and Haonan Chen and Wuke Qiu and Yuwei Duan and Chentong Liao and Ruipeng Li and Liyang Yu and Qiang Peng}, doi = {10.1002/advs.202414712}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414712}, shortjournal = {Adv. Sci.}, title = {Minimizing energy loss by designing multifunctional solid additives to independent regulation of donor and acceptor layers for efficient LBL polymer solar cells}, volume = {12}, year = {2025}, }
• (2025). Sandwich miura-ori enabled large area, super resolution tactile skin for Human–Machine interactions. ADVS, 12(18), 2414580. (www)

  @article{ , abstract = {With substantial advances in materials science and electronics, flexible tactile sensors have emerged as a promising sector with extensive applications, notably in human-machine interactions. However, achieving large-area sensing with few sensing units at a low cost remains a challenge; the use of sensor arrays will complicate wiring and increase costs. To solve these issues, a sandwich Miura-ori (SMo)-enabled super-resolution tactile skin capable of resolving normal and shear forces is proposed, and a theoretical model that incorporates the impact of actual manufacturing process is also developed, enabling the model to be employed for different tactile skins following calibration. Using machine learning techniques, the proposed tactile skin can accurately localize touch inputs (average localization error of 1.89 mm) and estimate the external force (average estimation error of 8%). Furthermore, a curved SMo skin is designed and fabricated using the tessellation algorithm, then installed on a robotic arm to control the motion, demonstrating its potential in human-machine interactions. This research introduces a straightforward and cost-effective approach to the design and manufacturing of super-resolution tactile skins, and it also offers a valuable solution for future large-area tactile sensor technologies.}, archive = {J_ADVS}, author = {Qian Xu and Zhiwei Yang and Zhengjun Wang and Ruoqin Wang and Boyang Zhang and YikKin Cheung and Rui Jiao and Fan Shi and Wei Hong and Hongyu Yu}, doi = {10.1002/advs.202414580}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414580}, shortjournal = {Adv. Sci.}, title = {Sandwich miura-ori enabled large area, super resolution tactile skin for Human–Machine interactions}, volume = {12}, year = {2025}, }
• (2025). Microfluidics-based microcarriers for live-cell delivery. ADVS, 12(18), 2414410. (www)

  @article{ , abstract = {Live-cell therapy has emerged as a revolutionary treatment modality, providing a novel therapeutic avenue for intractable diseases. However, a major challenge in live-cell therapy is to maintain live-cell viability and efficacy during the treatment. Microcarriers are crucial for enhancing cell retention, viability, and functions by providing a protective scaffold and creating a supportive environment for live-cell proliferation and metabolism. For microcarrier construction, the microfluidic technology demonstrates excellent characteristics in terms of controllability over microcarrier size and morphology as well as potential for high-throughput production. To date, multiple live-cell delivery microcarrier types (e.g., microspheres, microfibers, and microneedles) are prepared via microfluidic liquid templates to meet different therapeutic needs. In this review, recent developments in microfluidics-based microcarriers for live-cell delivery are presented. It is focused on categorizing the structural design of microfluidic-derived cell-laden microcarriers, and summarizing various therapeutic applications. Finally, an outlook is provided on the future challenges and opportunities in this field.}, archive = {J_ADVS}, author = {Zhonglin Fang and Xinyuan Yang and Chong Wang and Luoran Shang}, doi = {10.1002/advs.202414410}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414410}, shortjournal = {Adv. Sci.}, title = {Microfluidics-based microcarriers for live-cell delivery}, volume = {12}, year = {2025}, }
• (2025). Deep-UV light-emitting based on the hBN:S/hBN: Mg homojunction. ADVS, 12(18), 2414353. (www)

  @article{ , abstract = {A hexagonal boron nitride (hBN) based p-n homo-junction is expected to demonstrate a great potential for being fabricated into an emitter (either light-emitting diode or laser diode) in the deep-UV spectral region. However, it remains a great challenge to achieve n-type conductive hBN. Herein, n-type hBN is obtained by means of doping sulfur into hBN. The structure and the electric properties of S-doped hBN is studied via density functional theory, indicating that the orbital coupling between S 3p and B 2p orbital introduces shallow donor energy levels. The S atoms in the multilayer structure demonstrate enhanced electron delocalization compared with its mono-layer counterpart, suggesting that multilayer hBN:S is more inclined to be n-type conductive than its mono-layer counterpart. Experimentally, a multilayer hBN:S sample is successfully grown on sapphire substrates, where the S content, up to 1.21%, is obtained. The hBN:S film shows an in-plane current of 1.6 nA using Ti as ohmic contact and 8.4 nA using Ni as Schottky contact, respectively. The donor level induced by the S atoms is located at 0.349 eV below the CBM. Finally, a vertically-stacked n-hBN/p-hBN (hBN:S/hBN: Mg) structured junction is grown, and demonstrating a promise for being fabricated into a deep-UV emitter.}, archive = {J_ADVS}, author = {Ransheng Chen and Qiang Li and Wannian Fang and Qifan Zhang and Jiaxing Li and Zhihao Zhang and Kangkang Liu and Feng Yun and Yanan Guo and Tao Wang and Yue Hao}, doi = {10.1002/advs.202414353}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414353}, shortjournal = {Adv. Sci.}, title = {Deep-UV light-emitting based on the hBN:S/hBN: Mg homojunction}, volume = {12}, year = {2025}, }
• (2025). Sperm-derived CircRNA-1572 regulates embryogenesis and zygotic genome activation by targeting CCNB2 via bta-miR-2478-L-2. ADVS, 12(18), 2414325. (www)

  @article{ , abstract = {Sperm non-coding RNAs, including micro RNAs, transfer RNA-derived small RNAs, and long non-coding RNAs, are pivotal in cellular cytoskeletal remodeling, early embryonic development, and offspring phenotypes. Despite the identification of circular RNAs (circRNAs) in mammals, the roles of sperm-derived circRNAs in embryogenesis remain largely unexplored. This study identify circRNA-1572, a sperm-derived circRNA deliver into oocytes during fertilization, through whole-transcriptome sequencing of porcine metaphase II (MII) oocytes, purified mature sperm, and in vitro fertilized pronuclear (PN) embryos. Functional assays confirm circRNA-1572 competitively binds to bta-miR-2478-L-2 through a “sponge” mechanism, regulating the expression of the target gene cyclin B2 ( CCNB2 ). Knockdown (KD) of circRNA-1572 or overexpression of bta-miR-2478-L-2 led to reduce levels of CCNB2 mRNA and protein, along with altered fibrous actin (F-actin) distribution and aberrant chromosomal organization, leading to increase developmental arrest and impair zygotic genome activation (ZGA) during early porcine embryogenesis. Importantly, these phenotypes are rescued upon supplementary mRNA of CCNB2 . Moreover, SMART-seq analysis reveals KD of CCNB2 resulted in delayed degradation of maternal transcripts in 2-cell embryos and delayed initiation of ZGA in 4-cell. This study provides novel insights into the molecular regulatory functions of sperm-derived circRNAs in early mammalian embryogenesis and underscores the impact of paternal factors on embryonic development.}, archive = {J_ADVS}, author = {Yanfang Wu and Yaochang Wei and Yuelin Li and Yiming Dou and YongQiang Yang and Hanghang Liu and Xiaoyan Wang and Zheng Wang and Jianmin Su and Yong Zhang and Yongsheng Wang}, doi = {10.1002/advs.202414325}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414325}, shortjournal = {Adv. Sci.}, title = {Sperm-derived CircRNA-1572 regulates embryogenesis and zygotic genome activation by targeting CCNB2 via bta-miR-2478-L-2}, volume = {12}, year = {2025}, }
• (2025). A model of epigenetic inheritance accounts for unexpected adaptation to unforeseen challenges. ADVS, 12(18), 2414297. (www)

  @article{ , abstract = {Accumulated evidence of transgenerational inheritance of epigenetic and symbiotic changes raises fundamental questions about the possible types, significance and duration of impacts on the population, as well as whether, and under which conditions, the inheritance of non-genetic changes confers long-term advantage to the population. To address these questions, a population epigenetics model of individuals undergoing stochastic changes and/or induced responses that are transmitted to the offspringis introduced. Potentially adaptive and maladaptive responses are represented, respectively, by environmentally driven changes that reduce and increase the selective pressure. Analytic solutions in a simplified case of populations that are exposed to either periodic or progressively deteriorating environments shows that acquisition and transmission of non-genetic changes that alleviate the selective pressure confer long-term advantage and may facilitate escape from extinction. Systematic analysis of outcomes as a function of population properties further identifies a non-traditional regime of adaptation mediated by stochastic changes that are rapidly acquired within a lifetime. Contrasting model predictions with experimental findings shows that inheritance of dynamically acquired changes enables rapid adaptation to unforeseen challenges and can account for population dynamics that is either unexpected or beyond the scope of traditional models.}, archive = {J_ADVS}, author = {Dino Osmanović and Yitzhak Rabin and Yoav Soen}, doi = {10.1002/advs.202414297}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414297}, shortjournal = {Adv. Sci.}, title = {A model of epigenetic inheritance accounts for unexpected adaptation to unforeseen challenges}, volume = {12}, year = {2025}, }
• (2025). ADAR1-HNRNPL-mediated CircCANX decline promotes autophagy in chronic obstructive pulmonary disease. ADVS, 12(18), 2414211. (www)

  @article{ , abstract = {Chronic obstructive pulmonary disease (COPD) is a characteristic chronic airway inflammatory disease that worsens over time, however, there are currently limited clinical therapeutics to suspend its progression. Circular RNAs (circRNAs), which have emerged as functional regulators in various diseases, including COPD, may server as new pharmacological targets in COPD. Here, it is identified a nuclear circRNA, circCANX, that is preferentially decreased in COPD. The linear splicing of CANX pre-mRNA, enhanced by the ADAR1-HNRNPL interaction, is responsible for the circCANX decline. Clinically, the higher circCANX expression is associated with a worse lung function index of FEV 1 /FVC among patients with COPD. CircCANX suppresses autophagy and stress granule (SG) formation to strengthen inflammation of COPD in vivo and in vitro. Mechanistically, circCANX recruits the tumor suppressor protein P53 (P53) mRNA and RNA helicase upstream frameshift 1 (UPF1) to form a ternary complex, which mediates P53 mRNA degradation through nonsense-mediated mRNA decay (NMD) process. Together, this study reveals an important circCANX-mediated regulatory mechanism in COPD, and provides new insights into the potential of circRNA-based drug and biomarker development for COPD.}, archive = {J_ADVS}, author = {Ting-Ting Chen and Yuan-Yuan Wei and Jia-Ying Kang and Da-Wei Zhang and Jing-Jing Ye and Xi-Shi Sun and Mei Hong and Wen-Ting Zhang and Hui-Mei Wu and Zhen-Xing Ding and Guang-He Fei}, doi = {10.1002/advs.202414211}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414211}, shortjournal = {Adv. Sci.}, title = {ADAR1-HNRNPL-mediated CircCANX decline promotes autophagy in chronic obstructive pulmonary disease}, volume = {12}, year = {2025}, }
• (2025). High-viability circulating tumor cells sorting from whole blood at single cell level using laser-induced forward transfer-assisted microfiltration. ADVS, 12(18), 2414195. (www)

  @article{ , abstract = {The efficient isolation and molecular analysis of circulating tumor cells (CTCs) from whole blood at single-cell level are crucial for understanding tumor metastasis and developing personalized treatments. The viability of isolated cells is the key prerequisite for the downstream molecular analysis, especially for RNA sequencing. This study develops a laser-induced forward transfer -assisted microfiltration system (LIFT-AMFS) for high-viability CTC enrichment and retrieval from whole blood. The LIFT-compatible double-stepped microfilter (DSMF), central to this system, comprises two micropore layers: the lower layer's smaller micropores facilitate size-based cell separation, and the upper layer's larger micropores enable liquid encapsulating captured cells. By optimizing the design of the DSMFs, the system has a capture efficiency of 88% at the processing throughput of up to 15.0 mL min −1 during the microfilter-based size screening stage, with a single-cell yield of over 95% during the retrieval stage. The retrieved single cells, with high viability, are qualified for ex vivo culture and direct RNA sequencing. The cDNA yield from isolated CTCs surpassed 4.5 ng, sufficient for library construction. All single-cell sequencing data exhibited Q30 scores above 95.92%. The LIFT-AMFS shows promise in cellular and biomedical research.}, archive = {J_ADVS}, author = {Qingmei Xu and Yuntong Wang and Songtao Dou and Yang Xu and Zhenhe Xu and Han Xu and Yi Zhang and Yanming Xia and Ying Xue and Hang Li and Xiao Ma and Kunlong Zhang and Huan Wang and Fengzhou Ma and Qi Wang and Bei Li and Wei Wang}, doi = {10.1002/advs.202414195}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2414195}, shortjournal = {Adv. Sci.}, title = {High-viability circulating tumor cells sorting from whole blood at single cell level using laser-induced forward transfer-assisted microfiltration}, volume = {12}, year = {2025}, }
• (2025). Neural patterns of social pain in the brain-wide representations across social contexts. ADVS, 12(18), 2413795. (www)

  @article{ , abstract = {Empathy can be elicited by physiological pain, as well as in social contexts. Although physiological and different social contexts induce a strong subjective experience of empathy, the general and context-specific neural representations remain elusive. Here, it is combined fMRI with multivariate pattern analysis (MVPA) to establish neurofunctional models for social pain triggered by observing social exclusion and separation naturistic stimuli. The findings revealed that both social contexts engaged the empathy and social function networks. Notably, the intensity of pain empathy elicited by these two social stimuli does not significantly differentiate the neural representations of social exclusion and separation, suggesting context-specific neural representations underlying these experiences. Furthermore, this study established a model that traces the progression from physiological pain to social pain empathy. In conclusion, this study revealed the neural pathological foundations and interconnectedness of empathy induced by social and physiological stimuli and provide robust neuromarkers to precisely evaluate empathy across physiological and social domains.}, archive = {J_ADVS}, author = {Xiaodong Zhang and Peng Qing and Qi Liu and Can Liu and Lei Liu and Xianyang Gan and Kun Fu and Chunmei Lan and Xinqi Zhou and Keith M. Kendrick and Benjamin Becker and Weihua Zhao}, doi = {10.1002/advs.202413795}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413795}, shortjournal = {Adv. Sci.}, title = {Neural patterns of social pain in the brain-wide representations across social contexts}, volume = {12}, year = {2025}, }
• (2025). Magnetite nanoparticles with high affinity toward target protein for efficient and facile bio-separation. ADVS, 12(18), 2413605. (www)

  @article{ , abstract = {Magnetite nanoparticles (Fe 3 O 4 NPs) with molecular recognition capabilities offer significant potential for biomedical applications, yet existing surface protein imprinting methods often suffer from low efficiency. Herein, a surface enzyme-mediated polymerization strategy is exploited for surface imprinting of bovine serum albumin (BSA) onto Fe 3 O 4 NPs. This method, compatible with all vinyl monomers and operable under mild conditions, enables imprinting at high monomer concentrations while preventing nanoparticle agglomeration. Notably, increasing the pre-polymerization solution concentration enhances the pre-assembly of functional monomers and template molecules, thereby improving imprinting efficiency. Furthermore, replacing conventional crosslinkers with a polyglutamic acid-based peptide crosslinker introduces a pH-responsive helix-coil transition, allowing complete template removal under mild conditions and increasing the adsorption capacity and imprinting factor to 139.8 mg g⁻¹ and 10.36, respectively. The resulting BSA-imprinted Fe₃O₄ NPs exhibits high selectivity, robustness, and rapid adsorption kinetics while maintaining strong magnetic responsiveness for easy separation. These features allows for the selective extraction of BSA from bovine fetal serum, demonstrating the potential of this approach for biomedical applications, particularly in bioseparations.}, archive = {J_ADVS}, author = {Yafei Wang and Yaojing Zhang and Yibo Zhao and Zhuo Zhao and Jia Yao and Lei Zou and Yan Zhang and Ying Guan and Yongjun Zhang}, doi = {10.1002/advs.202413605}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413605}, shortjournal = {Adv. Sci.}, title = {Magnetite nanoparticles with high affinity toward target protein for efficient and facile bio-separation}, volume = {12}, year = {2025}, }
• (2025). Ru single atoms anchored on oxygen-vacancy-rich ZrO2-x/C for synergistically enhanced hydrogen oxidation. ADVS, 12(18), 2413569. (www)

  @article{ , abstract = {The hydrogen oxidation reaction (HOR) in alkaline media is pivotal for the advancement of anion exchange membrane fuel cells (AEMFCs), and the development of single-atom catalysts offers a promising solution for creating cost-effective, highly efficient HOR catalysts. Although the transition from nanoparticle to single-atom catalysts enhances catalytic activity, the stability of these single-atom sites remains a significant challenge. In this study, a highly active and stable alkaline HOR catalyst is successfully designed by incorporating Ru atoms into ZrO 2-x /C nanoparticles, forming the single atoms catalyst Ru-SA-ZrO 2-x /C. The catalyst exhibits an outstanding mass activity of 6789.4 mA mg Ru −1 at 50 mV, surpassing the Ru/C catalyst by 67 fold and the commercial Pt/C catalyst by 42.5 fold. Density functional theory (DFT) simulations reveal that the integration of Ru atoms into ZrO 2-x /C optimizes both the hydrogen bonding energy (HBE) and hydroxyl binding energy (OHBE), reducing the toxicity of Ru sites. This research opens a new pathway for the precise design of single-atom and metal nanoparticle hybrids, offering a promising direction for developing highly active electrocatalysts for alkaline HOR applications.}, archive = {J_ADVS}, author = {Xiaojuan Zhang and Chunchang Wang and Wenjun Cao and Qingqing Zhu and Chao Cheng and Jun Zheng and Haijuan Zhang and Youming Guo and Shouguo Huang and Yi Yu and Binghui Ge and Dongsheng Song and Yameng Fan and Zhenxiang Cheng}, doi = {10.1002/advs.202413569}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413569}, shortjournal = {Adv. Sci.}, title = {Ru single atoms anchored on oxygen-vacancy-rich ZrO2-x/C for synergistically enhanced hydrogen oxidation}, volume = {12}, year = {2025}, }
• (2025). Cryo-EM analysis of a tri-heme cytochrome-associated RC-LH1 complex from the marine photoheterotrophic bacterium dinoroseobacter shibae. ADVS, 12(18), 2413456. (www)

  @article{ , abstract = {The reaction center-light harvesting 1 (RC-LH1) complex converts solar energy into electrical energy, driving the initiation of photosynthesis. The authors present a cryo-electron microscopy structure of the RC-LH1 isolated from a marine photoheterotrophic bacterium Dinoroseobacter shibae . The RC comprises four subunits, including a three-heme cytochrome (Cyt) c protein, and is surrounded by a closed LH ring composed of 17 pairs of antenna subunits. Notably, a novel subunit with an N-terminal “helix-turn-helix” motif embedded in the gap between the RC and the LH ring is identified. The purified RC-LH1 complex exhibits high stability in solutions containing Mg 2+ or Ca 2+ . The periplasmic Cyt c 2 is predicted to bind at the junction between the Cyt subunit and the membrane plane, enabling electron transfer from Cyt c 2 to the proximal heme of the tri-heme Cyt, and subsequently to the special pair of bacteriochlorophylls. These findings provide structural insights into the efficient energy and electron transfer processes within a distinct type of RC-LH1, and shed light on evolutionary adaptations of photosynthesis.}, archive = {J_ADVS}, author = {Weiwei Wang and Yanting Liu and Jiayi Gu and Shaoya An and Cheng Ma and Haichun Gao and Nianzhi Jiao and Jian-Ren Shen and John Thomas Beatty and Michal Koblížek and Xing Zhang and Qiang Zheng and Jing-Hua Chen}, doi = {10.1002/advs.202413456}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413456}, shortjournal = {Adv. Sci.}, title = {Cryo-EM analysis of a tri-heme cytochrome-associated RC-LH1 complex from the marine photoheterotrophic bacterium dinoroseobacter shibae}, volume = {12}, year = {2025}, }
• (2025). Revealing the principle of progressively enhanced photocatalytic reactivity in dual single-atoms-mediated electronic interactions optimization of Cd/Te-TiO2. ADVS, 12(18), 2413379. (www)

  @article{ , abstract = {In this work, a CdTe@TiO 2 single atoms (SAs) catalysts is successfully synthesized, realizing unique portion of nonbonding oxygen-coordinated configuration of Cd─O─Te dimers coupling. Astonishingly, the 5th CdTe@TiO 2 (0.027 min −1 ) shows progressively augmenting phenomenon, accompanied with 2.73 times higher than that of fresh CdTe@TiO 2 (0.010 min −1 ) on the photocatalytic rate constant of gaseous toluene conversion. The incrementally enhanced photocatalytic activity is attributed to atomically dispersed Cd/Te SAs sites generation during the photoreduction process, and further leading to the optimized electron interactions between Cd, Te atoms, and TiO 2 NTs and causing a positive shift in the d-band center closer to the Fermi level. Density Functional Theory (DFT) calculations reveal that this unique Cd/Te SAs increasing phenomenon can mutually elevate the electronic density around Cd/Te SAs and generate a substantial local electric field at the interface. In essence, the free energy barriers of the benzene intermediates ring-opening as the rate-determining step appeared to significantly diminish tendency from 1.10 to 0.96 eV, in line with the ICOHP calculation of Cd/Te─O bonds in TS promoted from −2.43 to −3.49 eV. This work unearths the mechanism for ascendant electronic states of synergies dual-metal sites, providing a versatile strategy to tailor the SAs catalysts for solar energy conversion.}, archive = {J_ADVS}, author = {Yihang Zhang and Hao Zhao and Shan Jiang and Yanrong Zhang and Yong Chen and Jianyu Gong}, doi = {10.1002/advs.202413379}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413379}, shortjournal = {Adv. Sci.}, title = {Revealing the principle of progressively enhanced photocatalytic reactivity in dual single-atoms-mediated electronic interactions optimization of Cd/Te-TiO2}, volume = {12}, year = {2025}, }
• (2025). Citrullination of NF-κB p65 by PAD2 as a novel therapeutic target for modulating macrophage polarization in acute lung injury. ADVS, 12(18), 2413253. (www)

  @article{ , abstract = {Mediating protein citrullination, peptidyl arginine deiminase 2 (PAD2) has recently been reported to influence macrophage phenotypes. However, the mechanisms of PAD2 on macrophage function in Pseudomonas aeruginosa (PA)-induced acute lung injury syndrome (ALI) remains unclear. Utilizing single-cell RNA sequencing and mass spectrometry-based proteomics, a new citrullination site at arginine 171 (R171) is discovered within nuclear factor- κB (NF-κB) p65 catalyzed by PAD2, which modulates PAD2-NF-κB p65-importin α3 pathway and its downstream M1/M2 macrophage polarization. Building on these findings, a cell-specific targeted therapeutic strategy using gold nanoparticles (AuNPs) conjugated with a novel PAD2 inhibitor, AFM41a, and an intercellular adhesion molecule-1 (ICAM-1) antibody is developed. This approach enables the selective delivery of the inhibitor to M1-polarized macrophages in the PA-infected alveolar niche. In vivo, this nanomedicine reduces excessive inflammation and promotes M1-to-M2 polarization to inhibit ALI. This study highlights the role of PAD2-mediated citrullination in macrophage polarization and introduces a promising nanoparticle-based therapy for PA-induced ALI.}, archive = {J_ADVS}, author = {Xin Yu and Yujing Song and Tao Dong and Wenlu Ouyang and Chao Quan and Liujiazi Shao and Leonard Barasa and Paul R. Thompson and Mao Zhang and Jianjie Ma and Katsuo Kurabayashi and Yongqing Li}, doi = {10.1002/advs.202413253}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413253}, shortjournal = {Adv. Sci.}, title = {Citrullination of NF-κB p65 by PAD2 as a novel therapeutic target for modulating macrophage polarization in acute lung injury}, volume = {12}, year = {2025}, }
• (2025). Monolithic 3D oscillatory ising machine using reconfigurable FeFET routing for large-scalability and low-power consumption. ADVS, 12(18), 2413247. (www)

  @article{ , abstract = {Ising machines are attractive for efficiently solving NP-hard combinatorial optimization problems (COPs). In this work, a scalable monolithic-3D (M3D) oscillatory Ising machine (OIM) is proposed using ferroelectric field-effect transistors (FeFETs) serving as an in-memory routing switch (RS) and bi-stable resistor (biristor)-based oscillators for the first time. The M3D OIM achieves low static power consumption while offering high reconfigurability. Through careful control of FeFET routing switches, weights of the Ising model are embedded in coupled biristors. The performance is validated through simulations and experiments, in successfully solving King's graph sub-problems and the MaxCUT problem. By leveraging the intrinsic OIM features of parallel computing together with M3D integration, it is reported that the M3D OIM outperforms reported OIMs in scalability and speed. Such an approach provides new insights and significant potential for solving COPs.}, archive = {J_ADVS}, author = {Joon Pyo Kim and Song-Hyeon Kuk and Hyun Wook Kim and Jaeyong Jeong and Juhyuk Park and Bong Ho Kim and Jongmin Kim and Aida Todri-Sanial and Sanghyeon Kim}, doi = {10.1002/advs.202413247}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413247}, shortjournal = {Adv. Sci.}, title = {Monolithic 3D oscillatory ising machine using reconfigurable FeFET routing for large-scalability and low-power consumption}, volume = {12}, year = {2025}, }
• (2025). Targeting COPA to enhance erdafitinib sensitivity in FGFR-altered bladder cancer. ADVS, 12(18), 2413209. (www)

  @article{ , abstract = {Fibroblast growth factor receptor (FGFR) family aberrations are common in urothelial cancer. The FGFR tyrosine kinase inhibitor erdafitinib has been approved for locally advanced or metastatic urothelial cancer with FGFR2/3 alterations. Despite the initial efficacy of erdafitinib, resistance cannot be avoided. The molecular mechanisms underlying erdafitinib resistance have not been well investigated. Here, genome-wide CRISPR screen is performed and coatomer protein complex subunit α (COPA) is identified as a key target to enhance erdafitinib sensitivity. Functionally, the deficiency of COPA reduces the proliferation of FGFR-altered bladder cancer cells upon erdafitinib treatment. Mechanistically, COPA knockout increases the degradation of leucine-rich pentatricopeptide repeat containing (LRPPRC) protein, leading to reduced inhibitor of DNA binding 3 (ID3) mRNA stability in an m6A-dependent manner. Collectively, these findings reveal a novel mechanism of erdafitinib resistance, providing a potential therapeutic target for FGFR-altered bladder cancer.}, archive = {J_ADVS}, author = {Huayuan Zhao and Xincheng Gao and Yangkai Jiang and Yanchao Yu and Liang Wang and Jiayin Sun and Miao Wang and Xing Xiong and Chao Huang and Hui Zhang and Guosong Jiang}, doi = {10.1002/advs.202413209}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413209}, shortjournal = {Adv. Sci.}, title = {Targeting COPA to enhance erdafitinib sensitivity in FGFR-altered bladder cancer}, volume = {12}, year = {2025}, }
• (2025). Stacked nanosheet gate-all-around morphotropic phase boundary field-effect transistors. ADVS, 12(18), 2413090. (www)

  @article{ , abstract = {A material design method is proposed using ferroelectric (FE)–antiferroelectric (AFE) mixed-phase HfZrO 2 (HZO) to achieve performance improvements in morphotropic phase boundary (MPB) field-effect transistors (MPB-FETs), such as steep subthreshold swing ( SS ) and non-hysteretic on-current ( I on ) enhancement. Capacitance (small-signal and quasi-static) and transient current measurements of MPB-FETs confirmed that near-threshold voltage ( V TH ) capacitance amplification leads to I on boosts under high-speed and low-power conditions. For the first time, two-stacked nanosheet (NS) gate-all-around (GAA) MPB-FETs with optimized HZO, demonstrating superior short channel effect (SCE) immunity with enhanced current drivability is fabricated. Bias temperature instability (BTI) analyses revealed over-10-year endurance at 0.6 V and 120 °C. The NS MPB-FETs achieved a 24.1% I on gain, 82.5 mV operating voltage scalability, and a 30.7% AC performance improvement at V DD = 0.6 V compared to control MOSFETs with HfO 2 high-k dielectric. Transconductance benchmarks with industrial logic technologies confirmed that the MPB with mixed HZO enables effective oxide thickness scaling without mobility degradation, making NS MPB-FETs an ideal choice for low-power / high-performance CMOS technology.}, archive = {J_ADVS}, author = {Sihyun Kim and Hyun-Min Kim and Ki-Ryun Kwon and Daewoong Kwon}, doi = {10.1002/advs.202413090}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413090}, shortjournal = {Adv. Sci.}, title = {Stacked nanosheet gate-all-around morphotropic phase boundary field-effect transistors}, volume = {12}, year = {2025}, }
• (2025). Dissecting the spatial and single-cell transcriptomic architecture of cancer stem cell niche driving tumor progression in gastric cancer. ADVS, 12(18), 2413019. (www)

  @article{ , abstract = {Despite significant advancements in identifying novel therapeutic targets and compounds, cancer stem cells (CSCs) remain pivotal in driving therapeutic resistance and tumor progression in gastric cancer (GC). High-resolution knowledge of the transcriptional programs underlying the role of CSC niche in driving tumor stemness and progression is still lacking. Herein, spatial and single-cell RNA sequencing of 32 human gastric mucosa tissues at various stages of malignancy, illuminating the phenotypic plasticity of tumor epithelium and transcriptional trajectory from mature gastric chief cells to the CSC state, which is associated with activation of EGFR and WNT signaling pathways, is conducted. Moreover, the CSCs interact with not only the immunosuppressive CXCL13 + T cells and CCL18 + M2 macrophages to evade immune surveillance, but also the inflammatory cancer-associated fibroblasts (iCAFs) to promote tumorigenesis and maintain stemness, which construct the CSC niche leading to inferior prognosis. Notably, it is uncovered that amphiregulin (AREG) derived from iCAFs promotes tumor stemness by upregulating the expression of SOX9 in tumor cells, and contributes to drug resistance via the AREG-ERBB2 axis. This study provides valuable insight into the characteristics of CSC niche in driving tumor stemness and progression, offering novel perspective for designing effective strategies to overcome GC therapy resistance.}, archive = {J_ADVS}, author = {Guangyu Zhang and Xin Zhang and Wenting Pan and Xizhao Chen and Lingfei Wan and Chunjie Liu and Yuting Yong and Yue Zhao and Shuli Sang and Lihua Zhang and Sheng Yao and Yushu Guo and Mingmei Wang and Xinhui Wang and Guangdun Peng and Xinlong Yan and Yanchun Wang and Min Zhang}, doi = {10.1002/advs.202413019}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2413019}, shortjournal = {Adv. Sci.}, title = {Dissecting the spatial and single-cell transcriptomic architecture of cancer stem cell niche driving tumor progression in gastric cancer}, volume = {12}, year = {2025}, }
• (2025). A molecularly defined medullary network for control of respiratory homeostasis. ADVS, 12(18), 2412822. (www)

  @article{ , abstract = {The dynamic interaction between central respiratory chemoreceptors and the respiratory central pattern generator constitutes a critical homeostatic axis for stabilizing breathing rhythm and pattern, yet its circuit-level organization remains poorly characterized. Here, the functional connectivity between two key medullary hubs: the nucleus tractus solitarius (NTS) and the preBötzinger complex (preBötC) are systematically investigated. These findings delineate a medullary network primarily comprising Phox2b-expressing NTS neurons (NTS Phox2b ), GABAergic NTS neurons (NTS GABA ), and somatostatin (SST)-expressing preBötC neurons (preBötC SST ). Photostimulation of NTS Phox2b neurons projecting to the preBötC potently amplifies baseline ventilation, whereas genetic ablation of these neurons or knockout of their transient receptor potential channel 5 (TRPC5) significantly blunts the CO 2 -stimulated ventilatory responses. Conversely, NTS GABA neuron stimulation inhibits or halts breathing partially via monosynaptic inhibition of NTS Phox2b neurons projecting to the preBötC. Additionally, photostimulation of preBötC SST neurons projecting to the NTS drives deep and slow breathing through coordinated modulation of NTS GABA and NTS Phox2b neurons. These findings collectively identify an important medullary network that integrates chemosensory feedback with respiratory motor output, enabling dynamic tuning of breathing patterns to metabolic demands.}, archive = {J_ADVS}, author = {Tianjiao Deng and Xinyi Jing and Liuqi Shao and Yakun Wang and Congrui Fu and Hongxiao Yu and Xiaoyi Wang and Xue Zhao and Fanrao Kong and Yake Ji and Xiaochen Tian and Wei He and Shangyu Bi and Luo Shi and Hanqiao Wang and Fang Yuan and Sheng Wang}, doi = {10.1002/advs.202412822}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2412822}, shortjournal = {Adv. Sci.}, title = {A molecularly defined medullary network for control of respiratory homeostasis}, volume = {12}, year = {2025}, }
• (2025). Depletion of hepatic SREBP2 protects against hypercholesterolemia and atherosclerosis through the ANGPTL3-LPL axis. ADVS, 12(18), 2412677. (www)

  @article{ , abstract = {Lipolysis of triglyceride-rich lipoproteins by peripheral lipoprotein lipase (LPL) plays an essential role in maintaining systemic cholesterol/lipid homeostasis. Human genetic studies have unequivocally demonstrated that activation of LPL pathway reduces risks for both coronary artery disease (CAD) and type 2 diabetes (T2D). Although sterol regulatory element-binding protein 2 (SREBP2) is well established as the master transcription factor that regulates the hepatic biosynthesis of both cholesterol and fatty acids, whether and how its activity in liver interacts with peripheral LPL pathway remains unknown. Here, it is demonstrated that acute liver-specific depletion of SREBP2 results in divergent effects on the regulation of peripheral LPL activity in mice, depending on the presence or absence of low-density lipoprotein receptors (LDLR). SREBP2 deficiency drastically elevates peripheral LPL activity through downregulation of plasma angiopoietin-related protein 3 (ANGPTL3) levels in LDLR-deficient mice. Moreover, in addition to SREBP2's transcriptional regulation of ANGPTL3, it is found that SREBP2 promotes proteasome-based degradation of ANGPTL3 in the presence of LDLR. Remarkably, acute depletion of hepatic SREBP2 protects against hypercholesterolemia and atherosclerosis, in which atherosclerotic lesions are reduced by 45% compared to control littermates. Taken together, these findings outline a liver-peripheral crosstalk mediated by SREBP2-ANGPTL3-LPL axis and suggest that SREBP2 inhibition can be an effective strategy to tackle homozygous familial hypercholesterolemia (HoFH).}, archive = {J_ADVS}, author = {Yifan Wang and Jia You Sarafina Choe and Yu Shi and Thi Tun Thi and Xiaoyun Cao and Yang Hu and Kai Yan Cheng and Hui Li and Yang Ji and Yan Liu and Matthew Ackers-Johnson and Roger S.Y. Foo and Yujia Shen and Haojie Yu}, doi = {10.1002/advs.202412677}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2412677}, shortjournal = {Adv. Sci.}, title = {Depletion of hepatic SREBP2 protects against hypercholesterolemia and atherosclerosis through the ANGPTL3-LPL axis}, volume = {12}, year = {2025}, }
• (2025). Conditional overexpression of serpine2 promotes hair cell regeneration from lgr5+ progenitors in the neonatal mouse cochlea. ADVS, 12(18), 2412653. (www)

  @article{ , abstract = {Neonatal cochlear Lgr5+ progenitors retain limited hair cells (HCs) regenerative capacity, but the regulatory network remains incompletely defined. Serpin family E member 2 ( Serpine2 ) is shown to participate in regulating proliferation and differentiation of cochlear Lgr5+ progenitors in the previous in vitro study. Here, the expression pattern and in vivo roles of Serpine2 in HC regeneration are explored by transgenic mice. It is found that Serpine2 is expressed in the mouse cochlea after birth with a downward trend as the mice age. In addition, Serpine2 conditional overexpression in vivo in Lgr5+ progenitors of neonatal mice cochlea results in an increased number of ectopic HCs in a dose-dependent manner. Serpine2 knockdown ex vivo and in vivo can inhibit HC regeneration. EdU assay and lineage tracing assay demonstrate these ectopic HCs likely originate from Lgr5+ progenitors through direct transdifferentiation rather than through mitotic regeneration. Moreover, single-nucleus RNA sequencing analysis and mRNA level validation reveal that conditionally overexpressed Serpine2 likely induces HC regeneration via inhibiting sonic hedgehog (SHH) signal pathway and inducing Atoh1 and Pou4f3 transcription factor. In brief, these data indicate that Serpine2 plays a pivotal role in HC regeneration from Lgr5+ progenitors in the neonatal mouse cochlea, and this suggests a new avenue for future research into HC regeneration.}, archive = {J_ADVS}, author = {Hairong Xiao and Jiheng Wu and Lixuan Huang and Ying Ma and Leilei Wu and Yanqin Lin and Zixuan Ye and Xin Tan and Xujun Tang and Wei Tong and Mingchen Dai and Yintao Wang and Xia Sheng and Renjie Chai and Shasha Zhang}, doi = {10.1002/advs.202412653}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2412653}, shortjournal = {Adv. Sci.}, title = {Conditional overexpression of serpine2 promotes hair cell regeneration from lgr5+ progenitors in the neonatal mouse cochlea}, volume = {12}, year = {2025}, }
• (2025). The super enhancer-driven long noncoding RNA PRKCQ-AS1 promotes neuroblastoma tumorigenesis by interacting with MSI2 protein and is targetable by small molecule compounds. ADVS, 12(18), 2412520. (www)

  @article{ , abstract = {Tumorigenic drivers of MYCN gene nonamplified neuroblastoma remain largely uncharacterized. Long noncoding RNAs (lncRNAs) regulate tumorigenesis, however, there is little literature on therapeutic targeting of lncRNAs with small molecule compounds. Here PRKCQ-AS1 is identified as the lncRNA most overexpressed in MYCN nonamplified, compared with MYCN -amplified, neuroblastoma cell lines. PRKCQ-AS1 expression is controlled by super-enhancers, and PRKCQ-AS1 RNA bound to MSI2 protein. RNA immunoprecipitation and sequencing identified BMX mRNA as the transcript most significantly disrupted from binding to MSI2 protein, after PRKCQ-AS1 knockdown. PRKCQ-AS1 or MSI2 knockdown reduces, while its overexpression enhances, BMX mRNA stability and expression, ERK protein phosphorylation and MYCN nonamplified neuroblastoma cell proliferation. PRKCQ-AS1 knockdown significantly suppresses neuroblastoma progression in mice. In human neuroblastoma tissues, high levels of PRKCQ-AS1 and MSI2 expression correlate with poor patient outcomes, independent of current prognostic markers. AlphaScreen of a compound library identifies NSC617570 as an efficient inhibitor of PRKCQ-AS1 RNA and MSI2 protein interaction, and NSC617570 reduces BMX expression, ERK protein phosphorylation, neuroblastoma cell proliferation in vitro and tumor progression in mice. The study demonstrates that PRKCQ-AS1 RNA interacts with MSI2 protein to induce neuroblastoma tumorigenesis, and that targeting PRKCQ-AS1 and MSI2 interaction with small molecule compounds is an effective anticancer strategy.}, archive = {J_ADVS}, author = {Sujanna Mondal and Pei Y. Liu and Janith Seneviratne and Antoine De Weck and Pooja Venkat and Chelsea Mayoh and Jing Wu and Jesper Maag and Jingwei Chen and Matthew Wong and Nenad Bartonicek and Poh Khoo and Lei Jin and Louise E. Ludlow and David S. Ziegler and Toby Trahair and Pieter Mestdagh and Belamy B. Cheung and Jinyan Li and Marcel E. Dinger and Ian Street and Xu D. Zhang and Glenn M. Marshall and Tao Liu}, doi = {10.1002/advs.202412520}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2412520}, shortjournal = {Adv. Sci.}, title = {The super enhancer-driven long noncoding RNA PRKCQ-AS1 promotes neuroblastoma tumorigenesis by interacting with MSI2 protein and is targetable by small molecule compounds}, volume = {12}, year = {2025}, }
• (2025). Macrophage HM13/SPP enhances foamy macrophage formation and atherogenesis. ADVS, 12(18), 2412498. (www)

  @article{ , abstract = {Aryl Hydrocarbon Receptor-Interacting Protein (AIP) reduces macrophage cholesterol-ester accumulation and may prevent atherogenic foamy macrophage formation. Analyzing AIP -associated regulatory gene networks can aid in identifying key regulatory mechanism(s) underlying foamy macrophage formation. A weighted gene co-expression network analysis on the Stockholm Atherosclerosis Gene Expression (STAGE) patient cohort identifies AIP as a negative correlate of Histocompatibility Minor 13 ( HM13 ), which encodes the ER-associated degradation (ERAD) protein Signal Peptide Peptidase (HM13/SPP). The negative correlation between AIP and HM13/SPP on mRNA and protein levels is validated in oxLDL-stimulated macrophages and human plaque foamy macrophages. Mechanistically, AIP, via its chaperone interaction with Aryl Hydrocarbon Receptor (AHR), inhibits p38-c-JUN-mediated HM13 transactivation, thereby suppressing macrophage lipid accumulation. Myeloid HM13/SPP overexpression enhances oxLDL-induced foamy macrophage formation in vitro as well as atherogenesis and plaque foamy macrophage load in vivo, while myeloid HM13/SPP knockout produces the opposite effects. Mechanistically, myeloid HM13/SPP enhances oxLDL-induced foamy macrophage formation in vitro as well as atherogenesis and plaque foamy macrophage load in vivo via promoting ERAD-mediated proteasomal degradation of the metabolic regulator Heme Oxygenase-1 (HO-1). In conclusion, AIP downregulates macrophage HM13/SPP, a driver of oxLDL-induced lipid loading, foamy macrophage generation, and atherogenesis.}, archive = {J_ADVS}, author = {Yu Cao and Qirong Xie and Qiang Zheng and Jingping Zhang and Mengyu Yao and Zhongyong Du and Lujun Zhang and Tianyang Hu and Yunli Zhao and Jianlin Du and Yongyong Li and Yuxing Feng and ND Melgiri and Xiaodong Zhao and Rongzhong Huang and Yang Sun}, doi = {10.1002/advs.202412498}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2412498}, shortjournal = {Adv. Sci.}, title = {Macrophage HM13/SPP enhances foamy macrophage formation and atherogenesis}, volume = {12}, year = {2025}, }
• (2025). In situ halide vacancy tuning of low-dimensional lead perovskites to realize multiple adjustable luminescence performance. ADVS, 12(18), 2412459. (www)

  @article{ , abstract = {Surface defects play a crucial role in the photophysical properties and optoelectronic applications of perovskite materials. Although luminescent efficiency is improved through post-synthetic defect passivation, comprehensive optimization of photoluminescent performance via defect chemistry remains a significant challenge. Herein, a successful defect engineering strategy is demonstrated toward 0D perovskite of [DADPA]PbBr 5 (DADPA = diaminodipropylamine) single crystal to achieve multiple adjustable luminescent properties. Through fine-tuning the crystallization environment to diminish Br vacancy ( V Br ), [DADPA]PbBr 5 displays gradually evolutionary luminescence range from broadband blue-white to narrow green light emissions, with continuously adjustable dominant wavelengths (445–535 nm) and linewidths (134–27 nm). Meanwhile, the quantum yields increase significantly from 3.7% to 80.8%, and lifetime extends from 5.4 to 57.7 ns. This is the pioneering discovery in perovskite chemistry for simultaneous modification of multi-dimensional luminescent performances. Combined spectroscopic investigations and first-principles calculations indicate that the reducing V Br significantly narrows the bandgap and inhibits nonradiative recombination, which attenuates interband trap-state-associated broadband emission and facilitates the formation of bound exciton for enhanced emission efficiency. More remarkably, this universal strategy can be extended to other perovskite systems with similar luminescent adjustability, paving the way for applications of diverse perovskites with improved optoelectronic performance.}, archive = {J_ADVS}, author = {Chen Sun and Chang-Qing Jing and Dong-Yang Li and Meng-Han Dong and Ming-Xue An and Zhong-Hui Zhang and Cheng-Yang Yue and Honghan Fei and Xiao-Wu Lei}, doi = {10.1002/advs.202412459}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2412459}, shortjournal = {Adv. Sci.}, title = {In situ halide vacancy tuning of low-dimensional lead perovskites to realize multiple adjustable luminescence performance}, volume = {12}, year = {2025}, }
• (2025). Neuropeptide ecdysis-triggering hormone and its receptor mediate the fecundity improvement of ‘Candidatus liberibacter asiaticus’-infected diaphorina citri females and CLas proliferation. ADVS, 12(18), 2412384. (www)

  @article{ , abstract = {The severe Asiatic form of huanglongbing (HLB), caused by “ Candidatus Liberibacter asiaticus” ( C Las), threatens global citrus production via the citrus psyllid, Diaphorina citri . Culturing challenges of C Las necessitate reducing D. citri populations for disease management. C Las boosts the fecundity of C Las-positive ( C Las+) D. citri and fosters its own proliferation by modulating the insect host's juvenile hormone (JH), but the intricate endocrine regulatory mechanisms remain elusive. Here, it is reported that the D. citri ecdysis-triggering hormone (DcETH) and its receptor DcETHR play pivotal roles in the reciprocal benefits between C Las and D. citri within the ovaries, influencing energy metabolism and reproductive development in host insects; miR-210, negatively regulates DcETHR expression, contributing to this symbiotic interaction. C Las infection reduces 20-hydroxyecdysone (20E) levels and stimulates DcETH release, elevating JH production via DcETHR , enhancing fecundity and C Las proliferation. Furthermore, circulating JH levels suppress 20E production in C Las + ovaries. Collectively, the orchestrated functional interplay involving 20E, ETH, and JH increases energy metabolism and promotes the fecundity of C Las + D. citri and C Las proliferation. These insights not only broaden the knowledge of how plant pathogens manipulate the reproductive behavior of insect hosts but also offer novel targets and strategies for combatting HLB and D. citri .}, archive = {J_ADVS}, author = {Xiaoge Nian and Bo Wang and Paul Holford and George Andrew Charles Beattie and Shijian Tan and Weiwei Yuan and Yijing Cen and Yurong He and Songdou Zhang}, doi = {10.1002/advs.202412384}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2412384}, shortjournal = {Adv. Sci.}, title = {Neuropeptide ecdysis-triggering hormone and its receptor mediate the fecundity improvement of ‘Candidatus liberibacter asiaticus’-infected diaphorina citri females and CLas proliferation}, volume = {12}, year = {2025}, }
• (2025). Loss of golga7 suppresses oncogenic nras-driven leukemogenesis without detectable toxicity in adult mice. ADVS, 12(18), 2412208. (www)

  @article{ , abstract = {NRAS mutations are prevalent in human hematological malignancies and are also common in certain solid tumors, including melanoma and colon cancer. Despite their crucial role in oncogenesis, no effective therapies targeting NRAS have been developed. Inhibiting NRAS localization to the plasma membrane (PM) represents a promising strategy for cancer therapy, as its oncogenic signaling relies on PM localization. Knocking out Golgin subfamily A member 7 (Golga7) , an accessory protein of RAS palmitoyltransferases, through a conditional gene editing approach drastically suppresses the development of myeloid leukemia induced by the activation of Nras G12D/G12D knock-in alleles in mice. The loss of Golga7 disrupts NRAS G12D PM localization in bone marrow cells without altering the level of NRAS G12D palmitoylation. Notably, Golga7 is dispensable for normal hematopoiesis in adult mice. While constitutive Golga7 knockout leads to embryonic lethality, the ubiquitous knockout of Golga7 induced in adult mice does not manifest any measurable toxic effects. These findings indicate that GOLGA7 is an effective and safe therapeutic target for NRAS -driven leukemias.}, archive = {J_ADVS}, author = {Bo Jiao and Lei Yan and Rui Zhang and Wei Huang and Xinru Wang and Chenxuan Liu and Peihong Wang and Pengfei Xu and Jinzeng Wang and Zhou Fang and Donghe Li and Zhizhou Xia and Jiaoyang Li and Shiyu Ji and Qianqian Zhang and Min Wu and Shengyue Wang and Ping Liu and Ruibao Ren}, doi = {10.1002/advs.202412208}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2412208}, shortjournal = {Adv. Sci.}, title = {Loss of golga7 suppresses oncogenic nras-driven leukemogenesis without detectable toxicity in adult mice}, volume = {12}, year = {2025}, }
• (2025). Shared and unique neural codes for biological motion perception in humans and macaque monkeys. ADVS, 12(18), 2411562. (www)

  @article{ , abstract = {Throughout evolution, living organisms have honed the ability to swiftly recognize biological motion (BM) across species. However, how the brain processes within- and cross-species BM, and the evolutionary progression of these processes, remain unclear. To investigate these questions, the current study examined brain activity in the lateral temporal areas of humans and monkeys as they passively observed upright and inverted human and macaque BM stimuli. In humans, the middle temporal area (hMT+) responded to both human and macaque BM stimuli, while the right posterior superior temporal sulcus (hpSTS) exhibited selective responses to human BM stimuli. This selectivity is evidenced by an increased feedforward connection from hMT+ to hpSTS during the processing of human BM stimuli. In monkeys, the MT region processed BM stimuli from both species, but no subregion in the STS anterior to MT is specific to conspecific BM stimuli. A comparison of these findings suggests that upstream brain regions (i.e., MT) may retain homologous functions across species, while downstream brain regions (i.e., STS) may have undergone differentiation and specialization throughout evolution. These results provide insights into the commonalities and differences in the specialized visual pathway engaged in processing within- and cross-species BMs, as well as their functional divergence during evolution.}, archive = {J_ADVS}, author = {Yuhui Cheng and Yumeng Xin and Xiqian Lu and Tianshu Yang and Xiaohan Ma and Xiangyong Yuan and Ning Liu and Yi Jiang}, doi = {10.1002/advs.202411562}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2411562}, shortjournal = {Adv. Sci.}, title = {Shared and unique neural codes for biological motion perception in humans and macaque monkeys}, volume = {12}, year = {2025}, }
• (2025). Targeting replication fork processing synergizes with PARP inhibition to potentiate lethality in homologous recombination proficient ovarian cancers. ADVS, 12(18), 2410718. (www)

  @article{ , abstract = {Synthetic lethality in homologous recombination (HR)-deficient cancers caused by Poly (ADP-ribose) polymerase inhibitors (PARPi) has been classically attributed to its role in DNA repair. The mode of action of PARPi and resistance thereof are now believed to be predominantly replication associated. Therefore, effective combinatorial approaches of targeting replication fork processing along with HR-downregulation to target HR-proficient and possibly PARPi-resistant tumors are warranted. Stilbenes are a privileged class of molecules, which include resveratrol, pterostilbene, piceatannol, etc , that modulate both replication processes and RAD51-expression. In this investigation, by screening a small library of stilbenes, including in-house synthesized molecules, trans -4,4′-dihydroxystilbene (DHS) was discovered as a potent natural agent, which downregulates RAD51 expression and HR repair (GFP-reporter assay). DHS induces extensive synergistic cell death in ovarian cancers when combined with talazoparib (PARPi). Mechanistically, DHS elicits replication-stress through severely impeding replication fork progress, speed, and inducing fork-asymmetry. This leads to robust induction of single stranded DNA (ssDNA) gaps and poly-ADP-ribosylation (PARylation) in S-phase cells, signifying issues related to lagging (Okazaki) strand synthesis. PARPi, which abrogates PARylation, potentiates DHS induced ssDNA gaps, and their conversion into lethal double strand breaks through MRE11 action. Furthermore, the combination is highly effective in mitigating ovarian tumor xenograft growth in SCID mice and exhibited a good therapeutic-index with no/minimal tissue-toxicity.}, archive = {J_ADVS}, author = {Ganesh Pai Bellare and Kshama Kundu and Papiya Dey and Krupa Thankam Philip and Nitish Chauhan and Muskan Sharma and Sankarsingh Kesharsingh Rajput and Birija Sankar Patro}, doi = {10.1002/advs.202410718}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2410718}, shortjournal = {Adv. Sci.}, title = {Targeting replication fork processing synergizes with PARP inhibition to potentiate lethality in homologous recombination proficient ovarian cancers}, volume = {12}, year = {2025}, }
• (2025). Antigen-targeting inserted nanomicelles guide pre-existing immunity to kill head and neck cancer. ADVS, 12(18), 2410629. (www)

  @article{ , abstract = {A significant challenge in cancer therapy is the identification of suitable targets that are specifically and uniformly expressed across heterogeneous tumors. The efficacy of pre-existing antiviral immunity in tumor treatment is limited by the absence of corresponding targets. This study develops a novel platform of antigen-targeted inserted nanomicelles, preS1 (an antigen of hepatitis B virus)-pHLIP nanomicelles, in which tumor-targeting nanomicelles release antigens that label tumor tissue for pre-existing immunity-mediated lysis in situ. In animal models of head and neck cancers, including head and neck squamous cell carcinoma and anaplastic thyroid cancer, preS1-pHLIP nanomicelles effectively inhibited tumor growth, recurrence, and metastasis in animals pre-immunized with preS1. This therapeutic effect is associated with an increase in the proportion of preS1-specific B cells and activated tumor-specific T cells within the tumor microenvironment. Overall, this work has engineered a nanomicelle that can disguise tumor cells as viruses and achieve tumor killing through the pre-existing antiviral immune response. This strategy presents a novel approach for treating tumors with ambiguous therapeutic target profiles.}, archive = {J_ADVS}, author = {Lizhuo Zhang and Qingqing Feng and Chuanming Zheng and Yuanqiang Li and Xinyang Ge and Tiefeng Jin and Gaofeng Hu and Zhuo Tan and Jiafeng Wang and Jiajie Xu and Liehao Jiang and Dan Wang and Zhangguo Ying and Xiao Zhao and Keman Cheng and Qinglin Li and Minghua Ge}, doi = {10.1002/advs.202410629}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2410629}, shortjournal = {Adv. Sci.}, title = {Antigen-targeting inserted nanomicelles guide pre-existing immunity to kill head and neck cancer}, volume = {12}, year = {2025}, }
• (2025). Genome-wide silencer screening reveals key silencer modulating reprogramming efficiency in mouse induced pluripotent stem cells. ADVS, 12(18), 2408839. (www)

  @article{ , abstract = {The majority of the mouse genome is composed of non-coding regions, which harbor numerous regulatory sequences essential for gene regulation. While extensive research focuses on enhancers that activate gene expression, the role of silencers that repress gene expression remains less explored. In this study, the first genome-wide identification of silencers in the mouse genome is conducted. In mouse embryonic fibroblasts (MEFs) and embryonic stem cells (mESCs), 89 596 and 115 165 silencers are identified, respectively. These silencers are ubiquitously distributed across the genome and are predominantly associated with low-expression genes. Additionally, these silencers are mainly cell-specific and function by binding to repressive transcription factors (TFs). Further, these silencers are notably enriched with the histone modification H3K9me3. It is observed that the transformation between dual-function silencers and enhancers is correlated with intracellular transcription factor concentrations, accompanied by changes in epigenetic modifications. In terms of biological effects, we have identified silencers that can enhance the induction efficiency of MEFs and influence the pluripotency of mESCs. Collectively, this work offers the first comprehensive silencer landscape in the mouse genome and provides strong evidence for the role of silencers in the induction of induced pluripotent stem cells (iPSCs).}, archive = {J_ADVS}, author = {Xiusheng Zhu and Lei Huang and Guoli Li and Biao Deng and Xiaoxiao Wang and Hu Yang and Yuanyuan Zhang and Qiuhan Wen and Chao Wang and Jingshu Zhang and Yunxiang Zhao and Kui Li and Yuwen Liu}, doi = {10.1002/advs.202408839}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2408839}, shortjournal = {Adv. Sci.}, title = {Genome-wide silencer screening reveals key silencer modulating reprogramming efficiency in mouse induced pluripotent stem cells}, volume = {12}, year = {2025}, }
• (2025). FGF2 mediated USP42-PPARγ axis activation ameliorates liver oxidative damage and promotes regeneration. ADVS, 12(18), 2408724. (www)

  @article{ , abstract = {Liver regeneration is critical for maintaining whole-body homeostasis, especially under exposure to deadly chemical toxins. Understanding the molecular mechanisms underlying liver repair is critical for the development of intervention strategies to treat liver diseases. In this study, ubiquitin-specific Proteases 42 (USP42) is identified as a novel deubiquitinases (DUB) of peroxisome proliferators-activated receptor γ (PPARγ) in hepatocytes. This DUB interacted, deubiquitinated, and stabilized PPARγ, and increased PPARγ targeted proliferative and antioxidative gene expressions, which protects the liver from carbon tetrachloride (CCL4) induced oxidative injury and promotes liver regeneration. In addition, fibroblast growth factor 2 (FGF2) initiated USP42 expression and enhanced the interaction between USP42 and PPARγ during the liver regeneration process. Moreover, the PPARγ full agonist, rosiglitazone (RSG), possesses the ability to further reinforce the USP42-PPARγ interplay, which enlightens to construct of an extracellular vesicle-based targeting strategy to activate the liver USP42-PPARγ axis and promote liver regeneration. In summary, the work uncovers the importance of USP42-PPARγ axis-mediated liver tissue homeostasis and provides a promising regimen to target this protein-protein interplay for liver regeneration.}, archive = {J_ADVS}, author = {Nanfei Yang and Qiang Tian and Zhenli Lei and Shuxin Wang and Nan Cheng and Zhen Wang and Xianqin Jiang and Xuqun Zheng and Wenjing Xu and Minyan Ye and Longwei Zhao and Meiyun Wen and Jianlou Niu and Weijian Sun and Pingping Shen and Zhifeng Huang and Xiaokun Li}, doi = {10.1002/advs.202408724}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2408724}, shortjournal = {Adv. Sci.}, title = {FGF2 mediated USP42-PPARγ axis activation ameliorates liver oxidative damage and promotes regeneration}, volume = {12}, year = {2025}, }
• (2025). Epithelial cell mechanoresponse to matrix viscoelasticity and confinement within micropatterned viscoelastic hydrogels. ADVS, 12(18), 2408635. (www)

  @article{ , abstract = {Extracellular matrix (ECM) viscoelasticity has emerged as a potent regulator of physiological and pathological processes, including cancer progression. Spatial confinement within the ECM is also known to influence cell behavior in these contexts. However, the interplay between matrix viscoelasticity and spatial confinement in driving epithelial cell mechanotransduction is not well understood, as it relies on experiments employing purely elastic hydrogels. This work presents an innovative approach to fabricate and micropattern viscoelastic polyacrylamide hydrogels with independently tuneable Young's modulus and stress relaxation, specifically designed to mimic the mechanical properties observed during breast tumor progression, transitioning from a soft dissipative tissue to a stiff elastic one. Using this platform, this work demonstrates that matrix viscoelasticity differentially modulates breast epithelial cell spreading, adhesion, YAP nuclear import and cell migration, depending on the initial stiffness of the matrix. Furthermore, by imposing spatial confinement through micropatterning, this work demonstrates that confinement alters cellular responses to viscoelasticity, including cell spreading, mechanotransduction and migration. These findings establish ECM viscoelasticity as a key regulator of epithelial cell mechanoresponse and highlight the critical role of spatial confinement in soft, dissipative ECMs, which was a previously unexplored aspect.}, archive = {J_ADVS}, author = {Giuseppe Ciccone and Mariana Azevedo Gonzalez-Oliva and Marie Versaevel and Marco Cantini and Massimo Vassalli and Manuel Salmeron-Sanchez and Sylvain Gabriele}, doi = {10.1002/advs.202408635}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2408635}, shortjournal = {Adv. Sci.}, title = {Epithelial cell mechanoresponse to matrix viscoelasticity and confinement within micropatterned viscoelastic hydrogels}, volume = {12}, year = {2025}, }
• (2025). Developing quorum sensing-based collaborative dynamic control system in halomonas TD01. ADVS, 12(18), 2408083. (www)

  @article{ , abstract = {Dynamic control exhibits increasing significance in microbial cell factory engineering by precisely manipulating gene expression over time and levels. However, the practical uses of most dynamic control tools still remain challenging because of poor scale-up robustness, especially for non-model chassis. Herein, a quorum sensing (QS)-based collaborative dynamic control system is constructed in Halomonas TD by regrouping two orthogonal quorum-sensing modules into two cell types, namely cell-A harboring cinR-luxI and cell-B harboring luxR-cinI together with sfGFP driven by P cin and P lux promoters, respectively. Effective gene expression control with over 15-time dynamic foldchange is achieved by mixing cells A and B at different ratios and time points in a lab-scale fed-batch study. Besides, dynamic inhibitory and amplified control is further developed by cascading CRISPRi/dCas9 system and MmP1 RNA polymerase, respectively, yielding up to 80% repression efficiency and 30-time amplification foldchange under high cell density fermentation. Moreover, 500 mg L −1 indigo and 4.7 g L −1 superoxide dismutase (SOD) are obtained by engineered Halomonas using QS-based control tools in the fed-batch study, showing 1.5- and 1.0-fold higher, respectively, than the yields by recombinants induced by IPTG. This study exemplifies a standardized and streamlined inducer-free dynamic control pattern for metabolic engineering with promising robustness in scale-up fermentation contexts.}, archive = {J_ADVS}, author = {Yi-Na Lin and Yu-Xi Li and Ye Zheng and Yi-Hao Deng and Kai-Xuan Liu and Yue Gan and Hao Li and Jun Wang and Jia-Wen Peng and Rui-Zhe Deng and Huai-Ming Wang and Hui Wang and Jian-Wen Ye}, doi = {10.1002/advs.202408083}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2408083}, shortjournal = {Adv. Sci.}, title = {Developing quorum sensing-based collaborative dynamic control system in halomonas TD01}, volume = {12}, year = {2025}, }
• (2025). Advancing the identification of bioactive molecules and the construction of a synergistic drug delivery system in combating lung injury. ADVS, 12(18), 2407802. (www)

  @article{ , abstract = {In recent years, pneumonia caused by multiple viruses has posed a significant threat to public health, particularly affecting vulnerable populations such as the elderly and immunocompromised individuals. Current treatments primarily focused on antiviral medications, lacking “miracle cure” and innovative approaches for the pathological damage caused by viruses. Since 2019, Traditional Chinese Medicine (TCM) has shown remarkable efficacy in treating coronavirus disease 2019 (COVID-19). However, the application is hindered by intricate mechanisms, variable quality, and slow onset. Clinically, Ge-Gen Decoction (GGD) effectively reduced the severity in patients with viral infections. Taking COVID-19 as a case, the bioactive ingredients from GGD: glabridin (GLA) and puerarin (PUE) are identified. Interestingly, it was discovered that PUE can self-assemble into a 3D hydrogel structure upon heating and cooling, namely PUE@gel. This process mirrored the formation of gel-like precipitates in GGD post-decoction. Motivated by this phenomenon, a decoction-mimicking drug delivery system, glabridin─puerarin self-assembled hydrogel (GLA-PUE@gel) was constructed, which exhibits strong anti-inflammatory and antioxidant properties, comparable to GGD at the same dosage. Additionally, PUE that has a high biosafety threshold can competitively bind to angiotensin converting enzyme 2 (ACE2) on host cells, preventing SARS-CoV-2 from invading. This study offered a promising approach for treating virus-induced lung injury.}, archive = {J_ADVS}, author = {Jianhong Qi and Yanxia Wang and Huan Chen and Kaitian Wu and Pei Zhou and Yue Dou and Bingqi Xiong and Wei Zhou}, doi = {10.1002/advs.202407802}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2407802}, shortjournal = {Adv. Sci.}, title = {Advancing the identification of bioactive molecules and the construction of a synergistic drug delivery system in combating lung injury}, volume = {12}, year = {2025}, }
• (2025). Shrimp virus regulates ROS dynamics via the nrf2 pathway to facilitate viral replication. ADVS, 12(18), 2407695. (www)

  @article{ , abstract = {Reactive oxygen species (ROS) of hosts are widely involved in intracellular signaling and against pathogens. Viruses manipulate ROS homeostasis of hosts as a strategy to evade ROS-mediated negative effects of their infection, but the mechanisms remain unclear. The economically important aquaculture shrimp, Litopenaeus vannamei , is selected to investigate the molecular mechanism of how white spot syndrome virus (WSSV) regulates ROS dynamics and enhances viral replication. WSSV protein wsv220 binds to the repressor of shrimp nuclear factor erythroid 2-related factor 2 (LvNrf2), called Kelch-like ECH-associated protein 1 (LvKeap1), disrupting LvNrf2/LvKeap1 complex and facilitating LvNrf2 nuclear translocation. This activation of LvNrf2 causes up-regulation of antioxidant genes, including glucose-6-phosphate dehydrogenase (LvG6PDH), which increases nicotinamide adenine dinucleotide phosphate (NADPH) and glutathione (GSH) production, effectively eliminating excessive ROS. Moreover, WSSV exploits LvNrf2 to establish a positive feedback loop by up-regulating viral immediate early gene wsv051, which further enhances wsv220 expression. Knockdown of LvNrf2 or LvG6PDH reduces WSSV replication and increases host ROS levels. Therefore, WSSV hijacks LvNrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. These findings reveal a novel molecular mechanism of viral manipulation of host ROS dynamics and suggest potential antiviral strategies targeting LvNrf2 pathway.}, archive = {J_ADVS}, author = {Honghui He and Kai Yuan and Junming Pan and Shaoping Weng and Chaozheng Li and Yihong Chen and Jianguo He}, doi = {10.1002/advs.202407695}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2407695}, shortjournal = {Adv. Sci.}, title = {Shrimp virus regulates ROS dynamics via the nrf2 pathway to facilitate viral replication}, volume = {12}, year = {2025}, }
• (2025). ROS-driven nanoventilator for MRSA-induced acute lung injury treatment via in situ oxygen supply, anti-inflammation and immunomodulation. ADVS, 12(18), 2406060. (www)

  @article{ , abstract = {Hypoxia, inflammatory response and pathogen (bacterial or viral) infection are the three main factors that lead to death in patients with acute lung injury (ALI). Among them, hypoxia activates the expression of HIF-1α, further exacerbating the production of ROS and inflammatory response. Currently, anti-inflammatory and pathogen elimination treatment strategies have effectively alleviated infectious pneumonia, but improving lung hypoxia still faces challenges. Here, a vancomycin-loaded nanoventilator (SCVN) containing superoxide dismutase (SOD) and catalase (CAT) is developed, which is prepared by encapsulating SOD, CAT and vancomycin into a nanocapsule by in situ polymerization. This nanocapsule can effectively improve the stability and loading rate of enzymes, and enhance their enzyme cascade efficiency, thereby efficiently consuming •O 2 − and H 2 O 2 to generate O 2 in situ and reducing ROS level. More interestingly, in situ O 2 supply can effectively relieve lung hypoxia to reduce HIF-1α expression and balance the number of M1/M2 macrophages to reduce the levels of TNF-α, IL-1β and IL-6, thereby alleviating the inflammatory response. Meanwhile, vancomycin can target and kill MRSA, fundamentally solving the cause of pneumonia. This nanoventilator with antibacterial, anti-inflammatory, ROS scavenging and in situ O 2 supply functions will provide a universal clinical treatment strategy for ALI caused by pathogens.}, archive = {J_ADVS}, author = {Zheng Luo and Qi Wang and Xiaotong Fan and Xue Qi Koh and Xian Jun Loh and Caisheng Wu and Zibiao Li and Yun-Long Wu}, doi = {10.1002/advs.202406060}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2406060}, shortjournal = {Adv. Sci.}, title = {ROS-driven nanoventilator for MRSA-induced acute lung injury treatment via in situ oxygen supply, anti-inflammation and immunomodulation}, volume = {12}, year = {2025}, }
• (2025). Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis. ADVS, 12(18), 2405914. (www)

  @article{ , abstract = {Alveolar echinococcosis (AE) is caused by the chronic infection of E. multilocularis , whose tumor-like growth can lead to high fatality if improperly treated. The early diagnosis of infection and the treatment of advanced AE remain challenging. Herein, bulk RNA-seq, scRNA-seq, and spatial transcriptomics technologies are integrated, to reveal the host immune response mechanism against E. multilocularis both spatially and chronologically, collecting mouse liver samples at multiple timepoints up to 15 months post infection. These results unveil an unprecedented high-resolution spatial atlas of the E. multilocularis infection foci and the functional roles of neutrophils, Spp1 + macrophages, and fibroblasts during disease progression. The heterogeneity of neutrophil and macrophage subpopulations are critical in both parasite-killing and the occurrence of immunosuppression during AE progression. These findings indicate the transition of parasite control strategy from “active killing” to “negative segregation” by the host, providing instructive insights into the treatment strategy for echinococcosis.}, archive = {J_ADVS}, author = {Zhihua Ou and Li Li and Peidi Ren and Ting-Ting Zhou and Fan He and Jialing Chen and Huimin Cai and Xiumin Han and Yao-Dong Wu and Jiandong Li and Xiu-Rong Li and Qiming Tan and Wenhui Li and Qi Chen and Nian-Zhang Zhang and Xiuju He and Wei-Gang Chen and Yanping Zhao and Jiwen Sun and Qian Zhang and Yan-Tao Wu and Yingan Liang and Jie You and Guohai Hu and Xue-Qi Tian and Sha Liao and Bao-Quan Fu and Ao Chen and Xue-Peng Cai and Huanming Yang and Jian Wang and Xin Jin and Xun Xu and Wan-Zhong Jia and Junhua Li and Hong-Bin Yan}, doi = {10.1002/advs.202405914}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2405914}, shortjournal = {Adv. Sci.}, title = {Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis}, volume = {12}, year = {2025}, }
• (2025). Sustained vaccine exposure elicits more rapid, consistent, and broad humoral immune responses to multivalent influenza vaccines. ADVS, 12(18), 2404498. (www)

  @article{ , abstract = {With the ever-present threat of pandemics, it is imperative vaccine technologies eliciting broad and durable immunity to high-risk pathogens are developed. Yet, current annual influenza vaccines, for example, fail to provide robust immunity against the 3–4 homologous strains they contain, let alone heterologous strains. Herein, this study demonstrates that sustained delivery of multivalent influenza vaccines from an injectable polymer-nanoparticle (PNP) hydrogel technology induces more rapid, consistent, and potent humoral immune responses against multiple homologous viruses, as well as potent responses against heterologous viruses and potential pandemic subtypes H5N1, H7N9 and H9N2. Further, admixing PNP hydrogels with commercial influenza vaccines results in stronger hemagglutination inhibition against both heterologous and homologous viruses. Additional investigation shows this enhanced potency and breadth arise from higher affinity antibodies targeting both the hemagglutinin stem and head. Overall, this simple and effective sustained delivery platform for multivalent annual influenza vaccines generates durable, potent, and remarkably broad immunity to influenza.}, archive = {J_ADVS}, author = {Olivia M. Saouaf and Ben S. Ou and Ye Eun Song and Joshua J. Carter and Jerry Yan and Carolyn K. Jons and Christopher O. Barnes and Eric A. Appel}, doi = {10.1002/advs.202404498}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2404498}, shortjournal = {Adv. Sci.}, title = {Sustained vaccine exposure elicits more rapid, consistent, and broad humoral immune responses to multivalent influenza vaccines}, volume = {12}, year = {2025}, }
• (2025). Molybdenum-catalyzed asymmetric amination of α-hydroxy esters: Synthesis of α-amino acids. ADVS, 12(18), 2403437. (www)

  @article{ , abstract = {Unnatural α-amino acids are found in a wide variety of bioactive compounds ranging from proteins to pharmaceutical agents to materials science. As a result, the investigation of efficient and simple methods for their synthesis is a major purpose in reaction development. In this study, it is found that a catalyst based on molybdenum, an earth-abundant transition metal, can facilitate the amination of readily accessible α-hydroxy esters to afford N -protected unnatural α-amino acid esters in high yield. This simple process also enables enantioselective amination, which proceeds through cooperative catalysis of chiral molybdenum complex with chiral phosphoric acid (CPA), and complements earlier procedures to the catalytic synthesis of this important class of compounds. The obtained protected α-amino acid ester products are directly useful or further utilized for the synthesis of commercially available drugs and analogs.}, archive = {J_ADVS}, author = {Shahida Perveen and Tahir Rahman and Tariq Ali and Lingyun Wang and Junjie Zhang and Ajmal Khan}, doi = {10.1002/advs.202403437}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2403437}, shortjournal = {Adv. Sci.}, title = {Molybdenum-catalyzed asymmetric amination of α-hydroxy esters: Synthesis of α-amino acids}, volume = {12}, year = {2025}, }
• (2025). Autologous peripheral Vγ9Vδ2 t cell synergizes with αβ t cell through antigen presentation and BTN3A1 blockade in immunotherapy of cervical cancer. ADVS, 12(18), 2401230. (www)

  @article{ , abstract = {New treatment strategies are urgently needed for patients with advanced cervical cancer (CC). Here, a synergistic anti-CC effect of a novel combinatorial immunotherapy with adoptively transferred autologous Vγ9Vδ2 T cells and αβ T cells is shown. The pivotal role of both circulating and tumor-infiltrating Vγ9Vδ2 T cells in anti-CC immunity is uncovered. Importantly, autologous Vγ9Vδ2 T cells show a synergistic anti-CC effect with αβ T cells not only through killing tumor directly, but also by promoting the activation and tumoricidal activity of syngeneic αβ T cells through antigen presentation, which can be further boosted by conventional chemotherapy. Moreover, Vγ9Vδ2 T cells can restore the tumoricidal function of αβ T cell through competitively binding to BTN3A1, a TCR-Vγ9Vδ2 ligand on CC cells upregulated by IFN-γ derived from activated αβ T cell. These findings uncover a critical synergistic effect of autologous Vγ9Vδ2 T cells and αβ T cells in immunotherapy of CC and reveal the underlying mechanisms.}, archive = {J_ADVS}, author = {Min Wu and Jian Liu and Liting Liu and Yifan Yang and Hong Liu and Long Yu and Haihong Zeng and Shuo Yuan and Ruiyi Xu and Hangyu Liu and Han Jiang and Shen Qu and Liming Wang and Ying Chen and Jingyu Wang and Yuwei Zhang and Shan He and Ling Feng and Junyan Han and Wanjiang Zeng and Hui Wang and Yafei Huang}, doi = {10.1002/advs.202401230}, journal = {Advanced Science}, month = {5}, number = {18}, pages = {2401230}, shortjournal = {Adv. Sci.}, title = {Autologous peripheral Vγ9Vδ2 t cell synergizes with αβ t cell through antigen presentation and BTN3A1 blockade in immunotherapy of cervical cancer}, volume = {12}, year = {2025}, }
• (2025). Polysilazane-coated films achieving record-high moisture barrier performance with sub-10 seconds densification using high-power VUV irradiation (Adv. sci. 17/2025). ADVS, 12(17), 2570128. (www)

  @article{ , archive = {J_ADVS}, author = {Luyang Song and He Sun and Yoshiyuki Suzuri}, doi = {10.1002/advs.202570128}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2570128}, shortjournal = {Adv. Sci.}, title = {Polysilazane-coated films achieving record-high moisture barrier performance with sub-10 seconds densification using high-power VUV irradiation (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). Large-area conductor-loaded PDMS flexible composites for wireless and chipless electromagnetic multiplexed temperature sensors (Adv. sci. 17/2025). ADVS, 12(17), 2570127. (www)

  @article{ , archive = {J_ADVS}, author = {Benjamin King and Nikolas Bruce and Mahmoud Wagih}, doi = {10.1002/advs.202570127}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2570127}, shortjournal = {Adv. Sci.}, title = {Large-area conductor-loaded PDMS flexible composites for wireless and chipless electromagnetic multiplexed temperature sensors (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). SIRT3-mediated deacetylation of DRP1K711 prevents mitochondrial dysfunction in parkinson's disease (Adv. sci. 17/2025). ADVS, 12(17), 2570126. (www)

  @article{ , archive = {J_ADVS}, author = {Ye Xi and Kai Tao and Xiaomin Wen and Dayun Feng and Zifan Mai and Hui Ding and Honghui Mao and Mingming Wang and Qian Yang and Jie Xiang and Jie Zhang and Shengxi Wu}, doi = {10.1002/advs.202570126}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2570126}, shortjournal = {Adv. Sci.}, title = {SIRT3-mediated deacetylation of DRP1K711 prevents mitochondrial dysfunction in parkinson's disease (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). Transcriptomic profiling unveils EDN3+ meningeal fibroblasts as key players in sturge-weber syndrome pathogenesis (Adv. sci. 17/2025). ADVS, 12(17), 2570125. (www)

  @article{ , archive = {J_ADVS}, author = {Daosheng Ai and Tianyue Ming and Xiaoli Li and Shu Wang and Zhanying Bi and Jinyi Zuo and Zizhang Cheng and Weijin Sun and Mingguo Xie and Fengzhi Li and Xiongfei Wang and Xueling Qi and Guoming Luan and Woo-ping Ge and Yuguang Guan}, doi = {10.1002/advs.202570125}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2570125}, shortjournal = {Adv. Sci.}, title = {Transcriptomic profiling unveils EDN3+ meningeal fibroblasts as key players in sturge-weber syndrome pathogenesis (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). Metal-organic framework-based tribovoltaic textile for human body signal monitoring (Adv. sci. 17/2025). ADVS, 12(17), 2570123. (www)

  @article{ , archive = {J_ADVS}, author = {Yuanlong Li and Yinghong Wu and Alexander V Shokurov and Carlo Menon}, doi = {10.1002/advs.202570123}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2570123}, shortjournal = {Adv. Sci.}, title = {Metal-organic framework-based tribovoltaic textile for human body signal monitoring (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). Cubic phase-inducible zwitterionic phospholipids improve the functional delivery of mRNA (Adv. sci. 17/2025). ADVS, 12(17), 2570122. (www)

  @article{ , archive = {J_ADVS}, author = {Kazuki Iwakawa and Rikako Sato and Mariko Konaka and Yuma Yamada and Hideyoshi Harashima and Yusuke Sato}, doi = {10.1002/advs.202570122}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2570122}, shortjournal = {Adv. Sci.}, title = {Cubic phase-inducible zwitterionic phospholipids improve the functional delivery of mRNA (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). Metabolic-immune suppression mediated by the SIRT1-CX3CL1 axis induces functional enhancement of regulatory t cells in colorectal carcinoma (Adv. sci. 17/2025). ADVS, 12(17), 2570121. (www)

  @article{ , archive = {J_ADVS}, author = {Ruiyang Zi and Xiang Zhao and Limei Liu and Yijie Wang and Rui Zhang and Zhiheng Bian and Haoran Jiang and Taorui Liu and Yixin Sun and Han Peng and Xuesong Wang and Fanghao Lu and Chao Zhang and Fan Zhang and Qing Qin and Houjie Liang and Jianjun Li and Zhihao Wei and Yan Dong}, doi = {10.1002/advs.202570121}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2570121}, shortjournal = {Adv. Sci.}, title = {Metabolic-immune suppression mediated by the SIRT1-CX3CL1 axis induces functional enhancement of regulatory t cells in colorectal carcinoma (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). NF2 is essential for human endoderm development (Adv. sci. 17/2025). ADVS, 12(17), 2570120. (www)

  @article{ , archive = {J_ADVS}, author = {Minjin Jeong and Dongjun Han and Preetida Bhetariya and D. Bradley Welling and Miodrag Stojkovic and Konstantina M. Stankovic}, doi = {10.1002/advs.202570120}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2570120}, shortjournal = {Adv. Sci.}, title = {NF2 is essential for human endoderm development (Adv. sci. 17/2025)}, volume = {12}, year = {2025}, }
• (2025). PDCD11 stabilizes C-MYC oncoprotein by hindering C-MYC-SKP2 negative feedback loop to facilitate progression of p53-mutant breast and colon malignancies. ADVS, 12(17), 2502416. (www)

  @article{ , abstract = {C-MYC is a proto-oncoprotein whose dysregulation triggers tumorigenesis and tumor progression in ≈70% of cancer cases. It is presently demonstrated that aberrantly upregulated MYC is caused by the overexpressed and “extra-nucleolar” PDCD11 in p53-mutant breast and colon cancer cells, which is highly correlated to tumor progression, metastasis, and recurrence. In the nucleoplasm, PDCD11 binds to the TAD of C-MYC to prevent SKP2, a transcriptional target of C-MYC as well as one of the major E3 ligase components targeting C-MYC, from interacting with and ubiquitinating C-MYC in feedback. The ensuing stabilized C-MYC activates downstream signaling to facilitate the cellular G1/S transition, proliferation, and migration. PDCD11 silencing restores SKP2-mediated C-MYC degradation, thereby remarkably suppressing tumor growth and metastasis in nude mice. These findings highlight PDCD11 as a novel C-MYC partner and thereby offer a potential therapeutic rationale to challenge PDCD11-mediated “pro-stabilization” effect on C-MYC, a widely considered “undruggable” target, to combat C-MYC-driven malignancies with p53 mutation.}, archive = {J_ADVS}, author = {Li Ding and Wei Ni and Yichao Ma and Lin Xu and Zhiping Zhang and Kai Liao and Jingwen Li and Xinyu Mei and Zhun Wang and Huiqian Ge and Jiajia Li and Dong Tang and Xinyue Zhang}, doi = {10.1002/advs.202502416}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2502416}, shortjournal = {Adv. Sci.}, title = {PDCD11 stabilizes C-MYC oncoprotein by hindering C-MYC-SKP2 negative feedback loop to facilitate progression of p53-mutant breast and colon malignancies}, volume = {12}, year = {2025}, }
• (2025). Correction to “Circulating small extracellular vesicles involved in systemic regulation respond to RGC degeneration in glaucoma”. ADVS, 12(17), 2502324. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202502324}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2502324}, shortjournal = {Adv. Sci.}, title = {Correction to “Circulating small extracellular vesicles involved in systemic regulation respond to RGC degeneration in glaucoma”}, volume = {12}, year = {2025}, }
• (2025). Unlocking modulation rule of heterointerface engineering induced D-band center on polysulfides conversion in Lithium–Sulfur batteries. ADVS, 12(17), 2501940. (www)

  @article{ , abstract = {MOF-derived heterostructures have been widely utilized as S hosts to address the three issues faced by the sulfur (S) cathode in lithium–sulfur batteries. Precisely pinpointing the active center in the heterostructure and unlocking the modulation rule of heterostructure on polysulfides (LiPSs) conversion are particularly important. Herein, the two homologous hetero-hosts of ZIF-67-derived CoSe 2 @CoSe 0.25 S 1.75 /NC and CoSe 2 @CoS 2 /NC nanoparticles anchored in the nitrogen-doped carbon (NC) matrix are successfully constructed, and confirm that Co at the heterointerface is the primary active center, rather than Co within the individual phases. It is revealed that the ɛ d (d-band center) of Co in the heterostructure can be a significant descriptor for the adsorption ability and conversion ability to LiPSs, and the discharge-specific capacities, which describe a volcano curve as a function of ε d . It is also found that the best Li + storage property appears at CoSe 2 @CoSe 0.25 S 1.75 heterointerface among the five structures (CoSe 2 @CoSe 0.25 S 1.75 , CoSe 2 @CoS 2 , CoSe 0.25 S 1.75 , CoSe 2 , CoS 2 ). The capacity is up to 600 mAh g −1 with a large retention rate of 73.3% at 0.2 C after 100 cycles, and the capacity decay rate is only 0.083% per cycle at 1 C during 300 long-cycling process.}, archive = {J_ADVS}, author = {Wenbin Li and Ni Wang and Jingjie Pei and Dongyan Li and Guiqiang Cao and Ruixian Duan and Jingjing Wang and Xifei Li}, doi = {10.1002/advs.202501940}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2501940}, shortjournal = {Adv. Sci.}, title = {Unlocking modulation rule of heterointerface engineering induced D-band center on polysulfides conversion in Lithium–Sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). IFITM2 modulates endocytosis maintaining neural stem cells in developing neocortex. ADVS, 12(17), 2501593. (www)

  @article{ , abstract = {Brain development is orchestrated by a complex interplay of genetic and environmental signals, with endocytosis serving as a pivotal process in integrating extracellular cues. However, the specific role of endocytosis in neurogenesis remains unclear. We uncover a critical function of the interferon-induced transmembrane protein, IFITM2, essential for endocytic processes in radial glial cells (RGCs). IFITM2 is highly expressed near the ventricular surface in the developing brain. Loss of IFITM2 impairs endosome formation and disrupts RGC maintenance. Mechanistically, we confirmed that the YXXø endocytic motif on IFITM2 is essential for its subcellular localization, with mutations in this motif reducing endocytic vesicles. Additionally, the K82 and K87 residues of IFITM2 interact with phosphoinositides to promote endocytic vesicle formation. Polarized localization of phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) on the ventricular side suggests its role in vesicle formation. IFITM2 deficiency also leads to reduced phosphorylation of AKT and GSK3β. These findings highlight the essential role of IFITM2 in regulating endocytosis in RGCs, which is critical for maintaining neural stem cells and proper brain development, offering new insights into the connection between cellular signaling and neurogenesis in both mouse and human models.}, archive = {J_ADVS}, author = {Yuqing Lv and Wenzheng Zou and Lin Li and Shukui Zhang and Jiaqi Liang and Jiali Pu and Jianwei Jiao}, doi = {10.1002/advs.202501593}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2501593}, shortjournal = {Adv. Sci.}, title = {IFITM2 modulates endocytosis maintaining neural stem cells in developing neocortex}, volume = {12}, year = {2025}, }
• (2025). Flexible optoelectronic hybrid microfiber long-period grating multimodal sensor. ADVS, 12(17), 2501352. (www)

  @article{ , abstract = {Flexible wearable biosensors have emerged as a promising tool for tracking dynamic glycemic profiles of human body in diabetes management. However, it remains a challenge to balance the shrunken device space and multiple redundant sensing arrays for further advancement in miniaturization of multimodal sensors. Herein, this work proposes an entirely new optoelectronic hybrid multimodal optical fiber sensor which is composed of laser patterning of polydimethylsiloxane (PDMS) to form laser-induced graphene (LIG) as the interdigital electrodes, and a long period grating (LPG) prepared from an optical microfiber encapsulated into the PDMS modulated by periodical structure of LIG electrodes. This operation can simultaneously integrate two heterogeneous sensing mechanisms, optical and electrical, into a single sensor in a compact manner. Combining the LIG electrode with conductive hydrogel, a flexible glucose biosensor based on electrical mechanism is constructed by loading glucose oxidase into the hydrogel. Meanwhile, the microfiber LPG can also be served as a spectroscopically available sensor for biomechanical monitoring. Optical and electrical sensors can work simultaneously but independently of each other, particularly in the scene of wound healing for rat model and movement for human exercise. This platform represents a pivotal step toward multifunctional sensors that enable measurements of biomechanical information and glucose.}, archive = {J_ADVS}, author = {Zhenru Li and Li-Peng Sun and Yanzhen Tan and Zhiwei Wang and Xiao Yang and Tiansheng Huang and Jie Li and Yi Zhang and Bai-Ou Guan}, doi = {10.1002/advs.202501352}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2501352}, shortjournal = {Adv. Sci.}, title = {Flexible optoelectronic hybrid microfiber long-period grating multimodal sensor}, volume = {12}, year = {2025}, }
• (2025). Porous aromatic framework with multifunctional sites for effective recovery of various trace iodine species from water. ADVS, 12(17), 2500993. (www)

  @article{ , abstract = {Recovery of environmental iodine is of great significance for both recycling iodine resources and addressing iodine pollution. However, iodine is highly sensitive to environmental factors and exists in various chemical species, which complicates the recovery of trace iodine in aqueous systems. Here a porous aromatic framework (iPAF-TEPT) is presented with multifunctional adsorption sites for efficient recovery of various iodine species, including molecular iodine (I 2 ), iodide (I − and I 3 − ). The material utilizes a synergistic strategy combining charge-transfer interactions and Coulomb interactions to effectively adsorb different iodine species. Thanks to its high density of accessible ion exchange sites for I⁻ and I 3 ⁻, and nitrogen-rich sites for I 2 , iPAF-TEPT demonstrates an unprecedented adsorption capacity for various iodine forms. Notably, iPAF-TEPT achieves exceptional removal efficiency for trace iodine pollutants, even at concentrations as low as 100 ppb, making it the first promising single-framework material for highly efficient treatment of aqueous iodine contamination.}, archive = {J_ADVS}, author = {Yue Ma and Jinjiao Pan and Huazhen Rong and Yilei Zhang and Lu Liu and Yu Guo and Jiayi Ai and Yihui Yuan and Ning Wang}, doi = {10.1002/advs.202500993}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500993}, shortjournal = {Adv. Sci.}, title = {Porous aromatic framework with multifunctional sites for effective recovery of various trace iodine species from water}, volume = {12}, year = {2025}, }
• (2025). Optimization of lipid nanoparticles with robust efficiency for the delivery of protein therapeutics to augment cancer immunotherapy. ADVS, 12(17), 2500844. (www)

  @article{ , abstract = {Lipid nanoparticles (LNPs) have been successful in delivering nucleic acids like siRNA and mRNA, but face challenges in protein delivery due to limited protein encapsulation and endosome escape. In this study, a family of LNPs is developed with robust high efficiency in addressing the multiple barriers in cytosolic protein delivery by incorporating clinically approved ionizable lipids into traditional cationic LNPs. The combination of cationic and ionizable lipids enables efficient protein binding and endosomal escape. Optimized LNPs efficiently deliver various proteins, including antibodies, enzymes, toxins, and Cas9 into living cells with reserved functions. Moreover, the designed LNPs show high serum stability during protein delivery, and the serum albumin adsorbed on LNPs facilitates protein delivery via albumin receptor-mediated endocytosis, enabling highly efficient protein delivery in vivo. The optimized LNPs successfully deliver therapeutic proteins such as saporin and interleukin-10 (IL-10) to inhibit tumor growth in several animal models. The IL-10 loaded LNPs enhanced the proliferation and cytotoxicity of T cells and improved the antitumor effect of adoptive transferred OT-1 CD8 + T cells to melanoma. This study expands the applications of LNPs for the delivery of biomacromolecules, and the developed LNP formulations have enormous potential for the delivery of protein therapeutics to treat various diseases.}, archive = {J_ADVS}, author = {Lanfang Ren and Zeda Zhao and Yuqing Chao and Panting Yu and Zhoufang Mei and Bing Du and Yiyun Cheng}, doi = {10.1002/advs.202500844}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500844}, shortjournal = {Adv. Sci.}, title = {Optimization of lipid nanoparticles with robust efficiency for the delivery of protein therapeutics to augment cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Utilizing caenorhabditis elegans as a rapid and precise model for assessing amphetamine-type stimulants: A novel approach to evaluating new psychoactive substances activity and mechanisms. ADVS, 12(17), 2500808. (www)

  @article{ , abstract = {The surge of new psychoactive substances (NPS) poses significant public health challenges due to their unregulated status and diverse effects. However, existing in vivo models for evaluating their activities are limited. To address this gap, this study utilizes the model organism Caenorhabditis elegans ( C. elegans ) to evaluate the activity of amphetamine-type stimulants (ATS) and their analogs. The swimming-induced paralysis (SWIP) assay is employed to measure the acute responses of C. elegans to various ATS, including amphetamine (AMPH), methamphetamine (METH), 3,4-methylenedioxymethamphetamine (MDMA) and their enantiomers. The findings reveal distinct responses in wild-type and mutant C. elegans , highlighting the roles of dopaminergic and serotonergic pathways, particularly DOP-3 and SER-4 receptors. The assay also revealed that C. elegans can distinguish between the chiral forms of ATS. Additionally, structural activity relationships (SAR) are observed, with meta -R amphetamines showing more pronounced effects than ortho -R and para- R analogs. This study demonstrates the utility of C. elegans in rapidly assessing ATS activity and toxicity, providing a cost-effective and precise method for high-throughput testing of NPS. These results contribute to a better understanding of ATS pharmacology and offer a valuable framework for future research and potential regulatory applications.}, archive = {J_ADVS}, author = {Yuanpeng Li and Hongyuan Li and Hongshuang Wang and Xiaohui Wang}, doi = {10.1002/advs.202500808}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500808}, shortjournal = {Adv. Sci.}, title = {Utilizing caenorhabditis elegans as a rapid and precise model for assessing amphetamine-type stimulants: A novel approach to evaluating new psychoactive substances activity and mechanisms}, volume = {12}, year = {2025}, }
• (2025). Achieving dynamic circularly polarized luminescence with 2D hydrogen-bonded organic frameworks. ADVS, 12(17), 2500789. (www)

  @article{ , abstract = {Significant advances have been made in the preparation and application of luminescent hydrogen-bonded organic frameworks (HOFs) in recent years. These materials exhibit unique structural flexibility in accommodating guest molecules, rendering them promising candidates for dynamic applications. Herein, a 2D HOF material is presented, constructed by the binary assembly of 5,5′-bis(azanediyl)oxalyl diisophthalic acid and tetra(pyrid-4-ylphenyl)ethylene to achieve dynamic circularly polarized luminescence (CPL) with the aid of chiral guests. Efficient chirality transfer and CPLs are realized by incorporating chiral carvone molecules into the 1D channels of HOFs through hydrogen bonding. As a result of the interlayer contraction upon guest desorption, these HOF materials display dynamic CPLs with emission colors varying from cyan to yellow. The method of the hydrogen bonding-enhanced host-guest chirality transfer in combination with the guest desorption-triggered interlayer contraction provides a simple method to achieve dynamic chiroptical properties with porous materials.}, archive = {J_ADVS}, author = {Li Meng and Dian-Xue Ma and Zhong-Qiu Li and Tongling Liang and Zili Chen and Yu-Wu Zhong}, doi = {10.1002/advs.202500789}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500789}, shortjournal = {Adv. Sci.}, title = {Achieving dynamic circularly polarized luminescence with 2D hydrogen-bonded organic frameworks}, volume = {12}, year = {2025}, }
• (2025). Tunable transfer-hydrodeoxygenated upgrading of lignin-derived propylphenols to versatile value-added alkane-based chemicals. ADVS, 12(17), 2500687. (www)

  @article{ , abstract = {Catalytic refining of lignin holds promise for producing sustainable platform chemicals. In this work, a gaseous hydrogen-free catalytic hydrodeoxygenation system is developed for upgrading lignin-derived phenols to alkane chemicals. Commercially available Raney Ni and HZSM-5 are used as a combinational catalyst, with isopropanol serving as the hydrogen-donating solvent. By modifying the temperature and the ratio of Raney Ni to HZSM-5, the reaction pathways for hydrogenation and deoxygenation can be tailored to specific requirements. As a result, a 97.1% yield of alkane fuels is achieved, with 64.4% propylcyclohexane and 32.7% propylbenzene obtained in one-pot reaction from the hydrodeoxygenation of 2-methoxy-4-propylphenol using a 3:1 mass ratio of Ni to HZSM-5, further increasing the ratio of HZSM-5 leads to a selectively production of propylbenzene in 62.0% yield. Through careful regulation of the catalytic system and the design of hydrogenation–deoxygenation pathways, excellent yields of 4-propylcyclohexanol (92.2%), propylcyclohexene (93.3%), and propylcyclohexane (93.2%) are directionally achieved. The catalyst maintained a conversion rate of over 99% after five cycles, demonstrating excellent robustness. This study offers a strategic system that expedites the selective upgrading of lignin-derived chemicals, heralding a pathway toward sustainable fuels and chemicals.}, archive = {J_ADVS}, author = {Yanyan Yu and Yilin Li and Yuhan Lou and Mengyuan Chen and Yongzhuang Liu and Haipeng Yu}, doi = {10.1002/advs.202500687}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500687}, shortjournal = {Adv. Sci.}, title = {Tunable transfer-hydrodeoxygenated upgrading of lignin-derived propylphenols to versatile value-added alkane-based chemicals}, volume = {12}, year = {2025}, }
• (2025). Unraveling the interfacial carrier behavior in PtSe2–MoSe2 heterostructures: Insights from combined pump-probe spectroscopy and scanning tunneling microscopy. ADVS, 12(17), 2500598. (www)

  @article{ , abstract = {Interfacial carrier behavior is vital for modifying the optoelectronic performance of 2D materials with atomical thickness, yet understanding exciton dynamics within hetero-phase heterojunctions at the nanoscale remains elusive. Here, carrier dynamics at the interface in molecular beam epitaxy grown 1T PtSe 2 –1H MoSe 2 heterostructures are revealed by ultrafast pump-probe spectroscopy, and the corresponding mechanisms are studied by combining scanning tunneling microscopy/spectroscopy (STM/STS). The difference in exciton lifetimes and signal intensities in the heterostructures at the energies larger and narrower than the bandgap of MoSe 2 demonstrates both electrons and holes transfer at the interface of PtSe 2 and MoSe 2 monolayers. Such bipolar transfer is interpreted through both the type-I (lateral) and type-II (vertical) band alignments revealed by STS measurements across the heterojunctions interface. Besides, it also shows that the band alignment modification of in-plane heterojunctions by a specific conductive substrate can fairly alter the exciton dynamics at the interface. This work provides a comprehensive insight into the carrier dynamics in PtSe 2 –MoSe 2 heterostructures with high spatial and temporal resolutions and may be beneficial for their design in optoelectronic devices.}, archive = {J_ADVS}, author = {Weili Zhang and Hu Chen and Jiangbo Peng and Xiaoguang Pan and Hangxin Bai and Fangli Jing and Hailong Qiu and Zhanggui Hu and Yicheng Wu and Hongjun Liu}, doi = {10.1002/advs.202500598}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500598}, shortjournal = {Adv. Sci.}, title = {Unraveling the interfacial carrier behavior in PtSe2–MoSe2 heterostructures: Insights from combined pump-probe spectroscopy and scanning tunneling microscopy}, volume = {12}, year = {2025}, }
• (2025). Dopant-regulated piezocatalysts evoke sonopiezoelectric and enzymatic PANoptosis for synergistic cancer therapy. ADVS, 12(17), 2500406. (www)

  @article{ , abstract = {Piezocatalyst-enabled sonopiezoelectric therapy offers noninvasive treatment with high spatiotemporal selectivity, yet existing piezocatalysts are limited by suboptimal efficacy, cancer cell resistance to oxidative stress, and biosafety concerns. Here, hafnia (HfO 2 ), one of the only few FDA-approved inorganic nanomaterials for clinical trials, is identified as a promising piezocatalyst with high translational potential for sonopiezoelectric and enzymatic PANoptosis-boosted nanocatalytic therapy. Specifically, engineered transition metal-substituted HfO 2 nanocatalysts are synthesized to optimize piezoelectric and enzyme-mimicking activities. Among these, Mn-substituted HfO 2 with a 20% Mn ratio (HMO) demonstrates superior performance in sono-triggered reactive oxygen species generation, attributed to its reduced bandgap and increased oxygen vacancies. HMO also exhibits multiple enzyme-mimicking activities, including peroxidase (POD), catalase (CAT), and glutathione peroxidase (GPx), amplifying oxidative stress through tumor-specific catalytic reactions. These dual catalytic effects enable the activation of cancer cell PANoptosis to elicit a robust antitumor immune response. Biological evaluations show significant tumor suppression and antitumor immune responses by HMO-mediated nanocatalytic therapy. Unlike utilizing the radiosensitization ability of HfO 2 in the clinic, this work unveils the distinctive sonopiezoelectric effect and multienzymatic activities of HfO 2 -based nanocatalysts for biomedical applications, holding the potential to overcome the challenges of radiation damage associated with radiotherapy.}, archive = {J_ADVS}, author = {Linhong Zhong and Xun Guo and Liming Deng and Xiaoting Wang and Hongye He and Nianhong Wu and Rui Tang and Liang Chen and Yu Chen and Pan Li}, doi = {10.1002/advs.202500406}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500406}, shortjournal = {Adv. Sci.}, title = {Dopant-regulated piezocatalysts evoke sonopiezoelectric and enzymatic PANoptosis for synergistic cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Flexible organic field-effect transistor (OFET) based 2T0C DRAM cells with 2-bit operation and extended retention. ADVS, 12(17), 2500300. (www)

  @article{ , abstract = {The emerging demand of data storage in wearable devices, flexible circuits based on organic semiconductor materials are encouraged, while organic field effect transistors face the challenges of low operating voltage and high on/off ratio. In this work, a high-performance flexible organic field effect transistor (OFET) is built with a threshold voltage range of −0.45 to −0.86 V and an on/off ratio between 10 6 and 10 8 . The subthreshold swing of the OFETs is lower than 60 mV dec −1 . Through finite element analysis, the OFET shows excellent mechanical stability owing to the stress relief during the bending process. Furthermore, a flexible 2T0C DRAM cell is demonstrated based on the OFETs. The stable electrical characteristics of the OFETs enable the 2T0C DRAM cell to achieve a retention time exceeding 300 s under both initial and bending conditions. Additionally, 2-bit memory operations are realized by adjusting the voltage of the word bit line ( V WBL ) and the voltage of the word write line ( V WWL ), demonstrating consistent performance in both the initial and after-bending state.}, archive = {J_ADVS}, author = {Xuemeng Hu and Zhenhai Li and Tianyang Feng and Jialin Meng and Qingxuan Li and Hao Zhu and Qingqing Sun and David Wei Zhang and Lin Chen}, doi = {10.1002/advs.202500300}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500300}, shortjournal = {Adv. Sci.}, title = {Flexible organic field-effect transistor (OFET) based 2T0C DRAM cells with 2-bit operation and extended retention}, volume = {12}, year = {2025}, }
• (2025). STING agonists and how to reach their full potential in cancer immunotherapy. ADVS, 12(17), 2500296. (www)

  @article{ , abstract = {As cancer continues to rank among the leading causes of death, the demand for novel treatments has never been higher. Immunotherapy shows promise, yet many solid tumors such as pancreatic cancer or glioblastoma remain resistant. In these, the “cold” tumor microenvironment with low immune cell infiltration and inactive anti-tumoral immune cells leads to increased tumor resistance to these drugs. This resistance has driven the development of several drug candidates, including stimulators of interferon genes (STING) agonists to reprogram the immune system to fight off tumors. Preclinical studies demonstrated that STING agonists can trigger the cancer immunity cycle and increase type I interferon secretion and T cell activation, which subsequently induces tumor regression. Despite promising preclinical data, biological and physical challenges persist in translating the success of STING agonists into clinical trials. Nonetheless, novel combination strategies are emerging, investigating the combination of these agonists with other immunotherapies, presenting encouraging preclinical results. This review will examine these potential combination strategies for STING agonists and assess the benefits and challenges of employing them in cancer immunotherapy.}, archive = {J_ADVS}, author = {Laura Gehrcken and Christophe Deben and Evelien Smits and Jonas R.M. Van Audenaerde}, doi = {10.1002/advs.202500296}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500296}, shortjournal = {Adv. Sci.}, title = {STING agonists and how to reach their full potential in cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Semiconducting open-shell radicals for precise tumor activatable phototheranostics. ADVS, 12(17), 2500293. (www)

  @article{ , abstract = {Semiconducting open-shell radicals (SORs) have promising potential for the development of phototheranostic agents, enabling tumor bioimaging and boosting tumorous reactive oxygen species (ROS). Herein, a new class of semiconducting perylene diimide (PDI), designated as PDI(Br) n with various numbers of bromine (Br) atoms modified on PDI's bay/ortho positions is reported. PDI(Br) n is demonstrated to transform into a radical anion, [PDI(Br) n ] •− , in a reducing solution, with a typical g -value of 2.0022. Specifically, [PDI(Br) 4/6 ] •− is generated in the weakly reductive tumor-mimicking solution and exhibits high stability in air. Quantum chemical kinetic simulation and ultrafast femtosecond transient absorption spectroscopy indicate that [PDI(Br) 6 ] •− has a low π–π stacking energy (0.35 eV), a fast electron transfer rate (192.4 ps) and energy gap of PDI(Br) 6 (Δ E S1, T1 = 1.307 eV, Δ E S1, T2 = 0.324 eV) respectively, which together result in excited-state charge transfer characters. The PDI(Br) 6 nanoparticle radicals, [PDI(Br) 6 ] NPs •− , specifically enable chemodynamic and type-I photodynamic ROS generation in tumors, including superoxide and hydroxyl radicals, which elicit immunogenic cell death effect. Also, [PDI(Br) 6 ] NPs •− facilitate activatable bioimaging-guided therapy due to their photoacoustic signal at 808 nm and NIR-II emission at 1115 nm. The work paves the way for the design of SORs for precise cancer theranostics.}, archive = {J_ADVS}, author = {Jie Zhang and Haifen Luo and Wen Ma and Jingqi Lv and Bo Wang and Fengwei Sun and Weijie Chi and Zhuting Fang and Zhen Yang}, doi = {10.1002/advs.202500293}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500293}, shortjournal = {Adv. Sci.}, title = {Semiconducting open-shell radicals for precise tumor activatable phototheranostics}, volume = {12}, year = {2025}, }
• (2025). Interface effects in metal-2D TMDs systems: Advancing the design and development electrocatalysts. ADVS, 12(17), 2500226. (www)

  @article{ , abstract = {2D transition metal dichalcogenides (2D TMDs) have emerged as promising candidates in electrocatalysis due to their unique band structures and tunable electronic properties. Nevertheless, establishing robust, low-resistance contacts between TMDs layers and conductive supports has remained a challenge. Their atomically thin nature makes these layers prone to structural disruption and undesired chemical interactions, hampering charge transfer and diminishing catalytic efficiency. Recently, the visualization of microscopic interface behaviors and atomic layer interactions between metals and 2D TMDs has led to the introduction of ohmic contact metal-TMDs electrocatalysts to address these challenges. Specifically, synergy at the metal-2D TMDs interface endows the catalyst with new functionalities, including enhanced redox activity and selective reactant immobilization, thus helping address core challenges in energy conversion and storage. This work first examines the fundamental structural traits of 2D TMDs and introduces design principles and strategies for ohmic metal-TMDs composites in electrocatalysis. The discussion covers methods for adjusting work function differences, constructing edge contacts in TMDs, incorporating interface doping/insertion, and engineering orbital hybridization or bonding interfaces. Additionally, this work analyzes the advantages, limitations, and future prospects of each approach, offering valuable insights for the development of efficient metal-semiconductor catalysts, electrodes, and energy conversion and storage devices.}, archive = {J_ADVS}, author = {Hao Hu and Zhongyuan Wang and Meilan Pan and Yumin Chen and Yinxi Han and Jiade Wang}, doi = {10.1002/advs.202500226}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500226}, shortjournal = {Adv. Sci.}, title = {Interface effects in metal-2D TMDs systems: Advancing the design and development electrocatalysts}, volume = {12}, year = {2025}, }
• (2025). Supercritical CO2 activation enables an exceptional methanol synthesis activity over the industrial Cu/ZnO/Al2O3 catalyst. ADVS, 12(17), 2500118. (www)

  @article{ , abstract = {The ternary Cu/ZnO/Al 2 O 3 catalyst is widely used in the industry for renewable methanol synthesis. The tenuous trade-off between the strong metal–support interaction (SMSI)-induced Cu–ZnO x interface and the accessible Cu surface strongly affects the activity of the final catalyst. Successes in the control of oxide migration on adsorbate-induced SMSI catalysts have motivated this to develop a supercritical CO 2 activation strategy to synchronously perfect the Cu 0 –O–Zn δ + interface and Cu 0 –Cu + surface sites through the manipulation of the adsorbate diffusion kinetics, which involves * OC 2 H 5 and “side-on” fixed CO 2 species. This findings illustrate that the adsorbate on ZnO x can facilitate its secondary uniform nucleation and induce a Zn x Al 2 O y spinel phase and that CO 2 adsorption on metallic Cu 0 produces an activated Cu x O amorphous shell. Such a structural evolution unlocks a dual-response pathway in methanol synthesis, thus enabling Cu/ZnO/Al 2 O 3 with a twofold increase in catalytic activity. This atomic-level design of active sites and understanding of supercritical CO 2 -induced structural evolution will guide the future development of high-performance supported metal catalysts.}, archive = {J_ADVS}, author = {Yannan Zhou and Jingyun Jiang and Yushun Wang and Ruijie Liu and Shouren Zhang and Jianfang Wang}, doi = {10.1002/advs.202500118}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500118}, shortjournal = {Adv. Sci.}, title = {Supercritical CO2 activation enables an exceptional methanol synthesis activity over the industrial Cu/ZnO/Al2O3 catalyst}, volume = {12}, year = {2025}, }
• (2025). CO-releasing polyoxometalates nanozyme with gut mucosal immunity and microbiota homeostasis remodeling effects for restoring intestinal barrier integrity. ADVS, 12(17), 2500116. (www)

  @article{ , abstract = {Disruption of the intestinal epithelial barrier, driven by imbalances in gut mucosal immunity and microbial homeostasis, is central to the onset and progression of inflammatory bowel disease (IBD). This study introduces a CO-releasing polyoxometalates (POMs) nanozyme (PMC), synthesized by coordinating pentacarbonyl manganese bromide with molybdenum-based POM nanoclusters. PMC demonstrates targeted accumulation at IBD-affected sites, efficient scavenging of reactive oxygen species (ROS), and responsive CO release, resulting in multiple therapeutic effects. Extensive in vitro and in vivo studies have validated the exceptional capacity of PMC to repair intestinal barrier, attributed to their potent antioxidant and anti-inflammatory properties, thereby achieving significant therapeutic efficacy in ulcerative colitis treatment. 16S rRNA sequencing indicated that PMC efficiently remodeled the gut microbiota composition. Single-cell RNA sequencing indicates a reduction in pro-inflammatory M1 macrophages, alongside suppressed ROS and inflammatory signaling pathways. Concurrently, an increase in reparative M2 macrophages and intestinal stem cells is observed, in addition to significant activation of the VEGF signaling pathway in macrophages and the NOTCH pathway in stem cells, underscoring the potential of PMC to restore immune balance and promote tissue repair. This study positions PMC as a promising, multifunctional therapeutic agent for IBD treatment owing to its robust intestinal barrier-restoring capability.}, archive = {J_ADVS}, author = {Hongyang Lu and Qiang Zhou and Jiayu Li and Shengming Xu and Li Yu and Yinci Zhu and He Zhang and Chengge Shi and Tianci Zuo and Mengzhu Xu and Mingli Su and Yanmei Zhang and Rongdang Hu and Quazi T. H. Shubhra and Hui Deng and Xiaowen Hu and Xiaojun Cai}, doi = {10.1002/advs.202500116}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2500116}, shortjournal = {Adv. Sci.}, title = {CO-releasing polyoxometalates nanozyme with gut mucosal immunity and microbiota homeostasis remodeling effects for restoring intestinal barrier integrity}, volume = {12}, year = {2025}, }
• (2025). Enhancing prime editing efficiency through modulation of methylation on the newly synthesized DNA strand and prolonged expression. ADVS, 12(17), 2417790. (www)

  @article{ , abstract = {Prime editors (PEs) have emerged as transformative tools for precision genome engineering, yet their broader application remains constrained by incomplete understanding of repair mechanisms. In this study, it is found that an increase in the methylation level of the CpG sequence on the newly generated strand can increase PE efficiency and that de novo DNA methyltransferases (DNMT3A/3B) are involved in the PE repair pathway. On the basis of these novel findings, the development of an episomal element-driven PE system (epiPE) achieved through the use of EBNA1/oriP are presented, which increases methylation levels around target sites and prolongs PE expression. A comparative analysis with canonical PE systems, including PE2, lentiPE2, and PE4max, reveals that the epiPE2 system significantly enhances editing efficiency while maintaining minimal insertion and deletion (indels) rates. Specifically, comparing to PE2, the epiPE2 system demonstrated an efficiency enhancement of 2.0 to 38.2-fold. In addition, the epiPE2 system is capable of efficient multiplex precise gene editing at up to 10 genetic loci in human cells. In conclusion, this findings increase the understanding of the PE repair mechanism, and presents the epiPE2 system as an efficient and multiplex-capable prime editing tool with potential applications in both basic research and translational studies.}, archive = {J_ADVS}, author = {Xiaosong Han and Xianghua Xu and Youcai Xiong and Guangxing Zhao and Ruigao He and Yinyu Su and Sheng Li and Changzhi Zhao and Xiaoning Xi and Yunxia Zhao and Xuewen Xu and Shengsong Xie and Heng Wang and Xinyun Li and Shuhong Zhao and Jinxue Ruan}, doi = {10.1002/advs.202417790}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417790}, shortjournal = {Adv. Sci.}, title = {Enhancing prime editing efficiency through modulation of methylation on the newly synthesized DNA strand and prolonged expression}, volume = {12}, year = {2025}, }
• (2025). A real-time cell death self-reporting theranostic agent for dynamic optimization of photodynamic therapy. ADVS, 12(17), 2417678. (www)

  @article{ , abstract = {The therapeutic efficiency of photodynamic therapy (PDT) hinges on the drug-light interval (DLI), yet conventional approaches relying on photosensitizer accumulation often lead to suboptimal irradiation and adverse side effects. Here, a real-time cell death self-reporting photodynamic theranostic nanoagent (CDPN) is presented that dynamically monitors extracellular potassium ion ([K⁺] ex ) fluctuations as direct indicators of tumor cell death. By exploiting [K⁺] ex dyshomeostasis associated with apoptosis and necrosis, CDPN combines a photosensitizer and a potassium-sensitive fluorophore within mesoporous silica nanoparticles, encapsulated by a K⁺-selective membrane for enhanced specificity. In vitro and in vivo studies validate that [K⁺] ex dynamics closely correlate with cell death, enabling precise evaluation of PDT efficacy and data-driven optimization of the DLI. Using a breast cancer model, CDPN-guided adjustments identify optimized DLI conditions, achieving significantly improved therapeutic outcomes. This study introduces a new paradigm for PDT, establishing a real-time, adaptable strategy for guiding treatment parameters and advancing precision oncology.}, archive = {J_ADVS}, author = {Wei Bian and Qiyue Wang and Cui He and Pan Tao and Juanjuan Zheng and Yulu Zhang and Jing Li and Fangyuan Li and Hongyan Jia and Daishun Ling}, doi = {10.1002/advs.202417678}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417678}, shortjournal = {Adv. Sci.}, title = {A real-time cell death self-reporting theranostic agent for dynamic optimization of photodynamic therapy}, volume = {12}, year = {2025}, }
• (2025). Single-crystalline β-Ga2O3 homoepitaxy on a near van der waals surface of (100) substrate. ADVS, 12(17), 2417436. (www)

  @article{ , abstract = {Gallium oxide (Ga₂O₃) is a promising wide-bandgap semiconductor for power devices, offering high breakdown voltage and low on-resistance. Among its polymorphs, β-Ga₂O₃ stands out due to the availability of high-quality, large-area single-crystalline substrates, particularly on the (100) surface, grown via melt-based bulk crystal growth. However, the low surface energy of β-Ga₂O₃ (100), akin to 2D materials, presents challenges in homoepitaxy, including poor nucleation and twin formation, which hinder its practical application. This study demonstrates the successful homoepitaxial growth of single-crystalline β-Ga₂O₃ on (100) substrates using a van der Waals epitaxial approach. By introducing an excess surfactant metal in metal-rich conditions at high temperature, a growth regime approximate thermal equilibrium is achieved, enhancing adatom diffusion and suppressing metastable twin phases. This adjustment enables the formation of well-ordered, single-crystalline nuclei and lateral stitching in a half-layer-by-half-layer growth mode, similar to 2D material growth. The result is twin-free, atomically flat, single-crystal thin films on on-axis β-Ga₂O₃ (100) substrates. These findings significantly improve the crystalline quality of epitaxial β-Ga₂O₃ on (100) substrates, demonstrating their potential for scalable production of high-performance, cost-effective β-Ga₂O₃-based power devices, and advancing their feasibility for industrial applications.}, archive = {J_ADVS}, author = {Tong Jiang and Hao Wang and Huaze Zhu and Junwei Cao and Xiaoqing Huo and Zhiqing Yang and Junshuai Li and Yaqing Ma and Shengnan Zhang and Xiang Xu and Wei Kong}, doi = {10.1002/advs.202417436}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417436}, shortjournal = {Adv. Sci.}, title = {Single-crystalline β-Ga2O3 homoepitaxy on a near van der waals surface of (100) substrate}, volume = {12}, year = {2025}, }
• (2025). A bias-tunable multispectral photodetector based on a GaN/TexSe1-x homo-type heterojunction with a unidirectional barrier. ADVS, 12(17), 2417428. (www)

  @article{ , abstract = {Multispectral detection technology captures characteristic spectral information across various wavebands, exhibiting substantial application potential. However, most currently reported multispectral photodetectors rely on intricate dual- or multi-junction structures, severely limiting material thickness, doping concentration, and band alignment design, thereby impeding widespread adoption. In this study, a bias-tunable multispectral photodetector featuring a straightforward single-junction design is introduced. The device comprises a Te x Se 1- x /GaN homo-type heterojunction with a unidirectional barrier. This structure effectively suppresses the majority-carrier dark current, yielding a low reverse dark current of ≈10 −12 A and a high rectification ratio of up to 10 5 . By adjusting the bias polarity and magnitude, the spectral response range of the device can be broadened from ultraviolet (UV) to short-wave infrared. Notably, the photodetection performance is exceptional: at 0 V bias, the device exhibits a responsivity of 0.25 A W −1 and a specific detectivity of 5.04 × 10 11 cm Hz 1/2 W −1 under 365 nm illumination; at −2 V bias, it achieves a responsivity of 0.58 A W −1 and a specific detectivity of 2.64 × 10 9 cm Hz 1/2 W −1 under 1060 nm illumination. Leveraging the bias-tunable spectral response characteristic of the device, proof-of-concept imaging is successfully demonstrated. This research presents a simplified and economical method for fabricating multispectral photodetectors.}, archive = {J_ADVS}, author = {Weijie Liu and Meng Peng and Maohua Chen and Yongming Zhao and Yiye Yu and Pengcheng Jian and Zunyu Liu and Yuhui Zeng and Yuang Luo and Xiantai Tian and Zhiwei Gao and Jiangnan Dai and Changqing Chen and Feng Wu and Weida Hu}, doi = {10.1002/advs.202417428}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417428}, shortjournal = {Adv. Sci.}, title = {A bias-tunable multispectral photodetector based on a GaN/TexSe1-x homo-type heterojunction with a unidirectional barrier}, volume = {12}, year = {2025}, }
• (2025). Plac1+ tumor cell-treg interplay supports tumorigenesis and progression of head and neck cancer. ADVS, 12(17), 2417312. (www)

  @article{ , abstract = {Cancer/testis antigen (CTA) family is restricted to germline and tumor cells and plays an important role during cancer initiation and progression. Five single-cell and two bulk RNA-seq datasets are integrated to screen genes in the CTAs family, revealing that Placenta specific protein 1 (Plac1) is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. Sp1 Transcription ( SP1) is identified as a specific regulator of Plac1 , which is confirmed by cleavage under targets and tagmentation (CUT&Tag)-seq. With in vitro experiments, in vivo subcutaneous tumor, and a transgenic autochthonous tumor model, it is revealed that Plac1 expression promotes HNSCC progression by inducing epidermal growth factor receptor endocytosis and recycling to increase PI3K/AKT signaling pathway activity. Then, it is revealed that Plac1 + tumor cells recruit CD4 + T cells via CXCL11/CXCR3 and induce Treg differentiation via PVR/TIGIT, which in turn activates the tumorigenic signaling of Plac1 + tumor cells via LTA/LTBR and forms a reciprocal protumor loop. These findings provide insights into molecular features of CTAs in HNSCC and facilitate the development of personalized treatment strategies.}, archive = {J_ADVS}, author = {Xiaoyan Meng and Zhonglong Liu and Lu Zhao and Ran Li and Luoman Gan and Liren Cao and Jingjing Sun and Lingfang Zhang and Yue He}, doi = {10.1002/advs.202417312}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417312}, shortjournal = {Adv. Sci.}, title = {Plac1+ tumor cell-treg interplay supports tumorigenesis and progression of head and neck cancer}, volume = {12}, year = {2025}, }
• (2025). Realizing intrinsically ultralow and glass-like thermal transport via chemical bonding engineering. ADVS, 12(17), 2417292. (www)

  @article{ , abstract = {Crystals exhibiting glass-like and low lattice thermal conductivity ( κ L $\kappa_{\rm L}$ ) are not only scientifically intriguing but also practically valuable in various applications, including thermal barrier coatings, thermoelectric energy conversion, and thermal management. However, such unusual κ L $\kappa _{\rm L}$ are typically observed only in compounds containing heavy elements, with large unit cells, or at high temperatures. In this study, chemical bonding principles are utilized to weaken the Ag–Ag bonds and enhance lattice anharmonicity. The incorporation of a chalcogen anion as a bridge ligand is proposed to facilitate phonon rattling in Ag 6 -octahedron-based compounds. Guided by this design strategy, five Ag 6 octahedron-based compounds, A Ag 3 X 2 ( A = Li, Na, and K; X = S and Se), which are characterized by low average atomic masses and exhibit exceptionally strong four-phonon scattering, are theoretically identified. Consequently, these compounds demonstrate ultralow thermal conductivities (0.3–0.6 W m −1 K −1 ) with minimal temperature dependence (T −0.1 ) across a wide temperature range. Experimental validation confirms that the κ L of NaAg 3 S 2 is 0.45 W m −1 K −1 within the temperature range of 200–550 K. The results clearly demonstrate that weak chemical bonding plays a crucial role in designing compounds with glass-like κ L , highlighting the effectiveness of chemical bonding engineering in achieving desired thermal transport properties.}, archive = {J_ADVS}, author = {Zhonghao Xia and Xingchen Shen and Jun Zhou and Yuling Huang and Yali Yang and Jiangang He and Yi Xia}, doi = {10.1002/advs.202417292}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417292}, shortjournal = {Adv. Sci.}, title = {Realizing intrinsically ultralow and glass-like thermal transport via chemical bonding engineering}, volume = {12}, year = {2025}, }
• (2025). Ultrafast exciton and spin dynamics of monolayer MoSi2N4 studied by non-degenerate pump-probe transient transmission spectroscopy. ADVS, 12(17), 2417209. (www)

  @article{ , abstract = {2D materials have attracted numerous attention for their potential applications in nano-photoelectronic and valleytronic devices. Recently, a new 2D material, MoSi 2 N 4 monolayer, is synthesized and reported, and predicted to have many unique properties. Here, its ultrafast photoelectron and spin dynamics using femtosecond-resolved transient differential transmission and Faraday rotation spectroscopies are investigated. Complex and diverse ultrafast dynamics of excitons are observed with increasing probe wavelength from 510 to 640 nm, including fully positive and negative monotonic decaying dynamics as well as an initial positive (negative) peak followed by slow negative (positive) recovery dynamics, and are explained well based on the band structure of MoSi 2 N 4 monolayer containing a deep defect level locating above the midpoint of direct bandgap at K valley. Spin polarization of A and B excitons is found controlled by the circular helicity of exciting light. The spin relaxation lifetime of B excitons is determined as ≈0.73 ps.}, archive = {J_ADVS}, author = {Huiping Wu and Su Sun and Chuan Xu and Ke Chen and Wencai Ren and Tianshu Lai}, doi = {10.1002/advs.202417209}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417209}, shortjournal = {Adv. Sci.}, title = {Ultrafast exciton and spin dynamics of monolayer MoSi2N4 studied by non-degenerate pump-probe transient transmission spectroscopy}, volume = {12}, year = {2025}, }
• (2025). Improved orthogonality in Naphthalimide/Cyanine dyad boosts superoxide generation: A tumor-targeted type-I photosensitizer for photodynamic therapy of tumor by inducing ferroptosis. ADVS, 12(17), 2417179. (www)

  @article{ , abstract = {It is highly desired to achieve Type-I photosensitizer (PS) to overcome the hypoxic limitation found in most clinically used PSs. Herein, a new heavy-atom-free Type-I PS T-BNCy5 is presented by incorporating a biotin-modified naphthalimide (NI) unit into the meso -position of a N -benzyl-functionalized, strongly photon-capturing pentamethine cyanine (Cy5) dye. Such molecular engineering induces a rigid orthogonal geometry between NI and Cy5 units by introducing an intramolecular sandwich-like π–π stacking assembly, which effectively promotes intersystem crossing (ISC) and greatly extends the triplet-state lifetime (τ = 389 µs), thereby markedly improving the superoxide (O 2 •− )-generating ability. In vitro assays reveal that T-BNCy5 specifically accumulates in mitochondria, where it not only generates O 2 •− under photoirradiation but also induces the burst of the most cytotoxic hydroxy radical (HO • ) by a cascade of biochemical reactions, ultimately triggering cell ferroptosis with the IC 50 value up to ≈0.45 µ m whether under normoxia or hypoxia. In vivo assays manifest that, benefiting from its biotin unit, T-BNCy5 displays a strong tumor-targeting ability, and after a single PDT treatment, it can not only ablate the tumor almost completely but also be cleared from the body through biosafe urinary excretion, indicating its potential for future clinical translation.}, archive = {J_ADVS}, author = {Guangxiao Yao and Junfeng Miao and Yingying Huo and Wei Guo}, doi = {10.1002/advs.202417179}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417179}, shortjournal = {Adv. Sci.}, title = {Improved orthogonality in Naphthalimide/Cyanine dyad boosts superoxide generation: A tumor-targeted type-I photosensitizer for photodynamic therapy of tumor by inducing ferroptosis}, volume = {12}, year = {2025}, }
• (2025). Updated insights into the mechanism of salt-induced aggregation-based single-molecule surface-enhanced raman spectroscopy. ADVS, 12(17), 2417025. (www)

  @article{ , abstract = {Since its discovery in 1997, the single molecule surface-enhanced Raman spectroscopy (SM-SERS) has attracted wide interest owing to its enormous potential in many fields. However, the commercialized applications of SM-SERS are still limited by the lack of a clear understanding of the relevant mechanism in the famous SM-SERS experiments. In this study, a salt-gradient model is proposed to deeply investigate the physical nature and update insights into the morphological, structural, and component evolution processes of Ag NPs from dispersed nanostructures to aggregation states in the salt-induced aggregation SERS strategy. A gradient interface is observed, where an ultrahigh sensitivity approaching a single molecule level, has been achieved in Ag colloidal system. An unusual dissolution of Ag, the release of Ag + ions from Ag NPs, and the final precipitation of AgCl can be evidenced. Thus, except for aggregation effect, the active AgCl packaging shell on the surface of Ag NPs remarkably improves the SERS property. This work not only reveals the physics processes and nature of SM-SERS but also offers a new way to exploit the SM-SERS into practical applications by means of designing different surface states of NPs and various activation compositions to meet diverse molecule systems.}, archive = {J_ADVS}, author = {Lingwei Li and Ruiyuan Zhang and Yu Guo and Jiacheng Ge and Si Lan and Feng Tian and Yi-Tao Long and Hongjun You and Jixiang Fang}, doi = {10.1002/advs.202417025}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2417025}, shortjournal = {Adv. Sci.}, title = {Updated insights into the mechanism of salt-induced aggregation-based single-molecule surface-enhanced raman spectroscopy}, volume = {12}, year = {2025}, }
• (2025). Green electrode processing enabled by fluoro-free multifunctional binders for lithium-ion batteries. ADVS, 12(17), 2416995. (www)

  @article{ , abstract = {The eco-friendly processing of conjugated polymer binder for lithium-ion batteries demands improved polymer solubility by introducing functional moieties, while this strategy will concurrently sacrifice polymer conductivity. Employing the polyfluorene-based binder poly(2,7-9,9 (di(oxy-2,5,8-trioxadecane))fluorene) (PFO), soluble in water-ethanol mixtures, a novel approach is presented to solve this trade-off, which features integration of aqueous solution processing with subsequent controlled thermal-induced cleavage of solubilizing side chains, to produce hierarchically ordered structures (HOS). The thermal processing can enhance the intermolecular π–π stacking of polyfluorene backbone for better electrochemical performance. Notably, HOS-PFO demonstrated a substantial 6–7 orders of magnitude enhancement in electronic conductivity, showcasing its potential as a functional binder for lithium-ion batteries. As an illustration, HOS-PFO protected SiOx anodes, utilizing in situ side chain decomposition of PFO surrounding SiOx particles after aqueous processing are fabricated. HOS-PFO contributed to the stable cycling and high-capacity retention of practical SiOx anodes (3.0 mAh cm −2 ), without the use of any conducting carbon additives or fluorinated electrolyte additives. It is proposed that this technique represents a universal approach for fabricating electrodes with conjugated polymer binders from aqueous solutions without compromising conductivity.}, archive = {J_ADVS}, author = {Xiuyu Jin and Ziting Zhu and Qiusu Miao and Chen Fang and Di Huang and Raynald Giovine and Linfeng Chen and Chaochao Dun and Jeffrey J. Urban and Yanbao Fu and Defu Li and Katie Liu and Yunfei Wang and Tianyu Zhu and Chenhui Zhu and Wei Tong and Gao Liu}, doi = {10.1002/advs.202416995}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416995}, shortjournal = {Adv. Sci.}, title = {Green electrode processing enabled by fluoro-free multifunctional binders for lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Wnt inhibition safeguards porcine embryonic stem cells from the acquisition of extraembryonic endoderm cell fates. ADVS, 12(17), 2416802. (www)

  @article{ , abstract = {Porcine embryonic stem cells (ESCs) are excellent models for exploring embryogenesis, producing genetically enhanced farm animals, and improving breeding. Various chemicals have been applied to generate porcine ESCs from embryos, which differ from mouse and human ESC derivation. Wnt inhibitors XAV939 or IWR1 are required to isolate and maintain porcine ESCs. How Wnt inhibitors specify porcine ESC fate decisions remains poorly understood. Additionally, whether porcine ESCs can be converted to extraembryonic endoderm (XEN) cells without genetic interventions has not been reported. Here, it is reported that Wnt inhibitors (i.e., XAV939 and IWR1) safeguard porcine ESCs from acquiring the XEN lineage. Porcine ESCs rely on Wnt inhibitors to maintain pluripotency. Without them, porcine ESCs exit from pluripotency and convert to XEN cells. An efficient strategy and culture conditions are further developed to directly derive porcine XEN cells from ESCs without gene editing. The resulting XEN cells from ESCs exhibit similar transcriptome and chromatin accessibility features to XEN cells from embryos and contribute to mouse extraembryonic tissues. This study will deepen the understanding of porcine pluripotency, lay the foundation for deriving high-quality porcine ESCs with germline chimerism and transmission, and provide valuable materials to study extraembryonic development and lineage segregation in livestock.}, archive = {J_ADVS}, author = {Hanning Wang and Liang Zhong and Zhuangfei Wang and Jinzhu Xiang and Duanqing Pei}, doi = {10.1002/advs.202416802}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416802}, shortjournal = {Adv. Sci.}, title = {Wnt inhibition safeguards porcine embryonic stem cells from the acquisition of extraembryonic endoderm cell fates}, volume = {12}, year = {2025}, }
• (2025). Highly oriented SiC@SiO2 ceramic fiber aerogels with good anisotropy of the thermal conductivity and high-temperature resistance. ADVS, 12(17), 2416740. (www)

  @article{ , abstract = {Here electrospinning and freeze-drying techniques are combined to fabricate an anisotropic SiC@SiO 2 ceramic fiber aerogels (A-SiC@SiO 2 -FAs). The anisotropic structure of the A-SiC@SiO 2 -FAs features aligned layers stacking layer-by-layer with the same direction and highly oriented 1D fibers inside each layer. The A-SiC@SiO 2 -FAs exhibit anisotropic thermal properties with an extremely low thermal conductivity of 0.018 W m −1 K −1 in the transverse direction (perpendicular to the SiC@SiO 2 nanofibers) and ≈5 times higher thermal conductivity of 0.0914 W m −1 K −1 in the axial direction due to the highly oriented SiC@SiO 2 nanofibers. The anisotropy factor of the A-SiC@SiO 2 -FAs is as high as 5.08, which exceeds most of the currently reported thermal insulation materials with anisotropic structural design, such as anisotropic wood aerogels, biaxially anisotropic PI/BC aerogels and anisotropic MXene foam, etc. The A-SiC@SiO 2 -FAs also have excellent thermal stability, maintaining structural integrity in oxidative environments at temperatures up to 1300 ° C. Moreover, these structurally distinct A-SiC@SiO 2 -FAs result in superior elastic deformation with a radial recoverable strain exceeding 60% and an axial specific modulus of 5.72 kN m kg −1 . These findings emphasize the potential of SiC nanofiber aerogels in extreme thermal environments and provide valuable insights for designing anisotropic insulation materials.}, archive = {J_ADVS}, author = {Zheng Zhang and Cui Liu and Nian Li and Wei Guo and Ying Li and Pengzhan Yang and Shudong Zhang and Zhenyang Wang}, doi = {10.1002/advs.202416740}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416740}, shortjournal = {Adv. Sci.}, title = {Highly oriented SiC@SiO2 ceramic fiber aerogels with good anisotropy of the thermal conductivity and high-temperature resistance}, volume = {12}, year = {2025}, }
• (2025). High-throughput proteoform imaging for revealing spatial-resolved changes in brain tissues associated with alzheimer's disease. ADVS, 12(17), 2416722. (www)

  @article{ , abstract = {Spatially resolved characterization of proteoforms has substantial potential to significantly advance the understanding of physiological and disease mechanisms. However, challenges remain regarding throughput and coverage. A robust method is developed for high-throughput proteoform imaging (HTPi) by combining matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) and region-specific top-down proteomic analysis. MALDI MSI enables the imaging of proteoforms on tissue sections at a rate of 7 h cm −2 (100-µm spatial resolution), and the identification sensitivity of the proteoforms is improved by narrow-bore monolithic columns with low adsorption, yielding 366 annotated proteoform images from the mouse brain. The obtained proteoform images reveals differential expression of individual proteoforms across the brain regions, and distinct spatial distribution patterns of various proteoforms generated from a single gene. Given its ability to visualize proteoform, HTPi is further applied to explore spatial pathological changes associated with Alzheimer's disease (AD) in 5 × FAD mice. 158 annotated proteoform images are obtained in hippocampal regions at 50-µm spatial resolution, illuminating 14 differential proteoforms in the subiculum region and highlighting their significant associations with amyloid-β pathology in AD. The results highlight the power of HTPi in unraveling the intricate molecular landscape of brain tissues and its potential in elucidating disease mechanisms.}, archive = {J_ADVS}, author = {Yue Sun and Dan Liu and Yu Liang and Xue Yang and Xinxin Liu and Baofeng Zhao and Zhen Liang and Yukui Zhang and Lihua Zhang}, doi = {10.1002/advs.202416722}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416722}, shortjournal = {Adv. Sci.}, title = {High-throughput proteoform imaging for revealing spatial-resolved changes in brain tissues associated with alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Wood biomolecules as agricultural adjuvants for effective suppression of droplet rebound from plant foliage. ADVS, 12(17), 2416686. (www)

  @article{ , abstract = {The agrochemical run-off associated with crop control is an unintended consequence of droplet rebound from plant foliage, which negatively affects crop performance and the environment. This is most critical in water-based formulations delivered on plant surfaces that are typically waxy and nonwetting. This study introduces an alternative to synthetic surfactants and high molecular weight polymers that are used as spreading agents for agrochemicals. Specifically, biopolymeric adjuvants (hemicelluloses and oligomeric lignin) extracted from wood by pressurized hot water are shown for their synergistic pinning capacity and surface activity that can effectively suppress droplet rebound from hydrophobic surfaces. Hemicellulose and lignin mixtures, alongside several model compounds, are investigated for understanding the dynamics of droplet impact and its correlation with biomacromolecule formations. The benefit of utilizing lean solutions (0.1 wt.% concentration) is highlighted for reducing droplet rebounding from leaves, outperforming synthetic systems in current use. For instance, a tenfold deposition improvement is demonstrated on citrus leaves, because of a significantly suppressed droplet roll-off. These results establish the excellent prospects of wood extracts to improve crop performance.}, archive = {J_ADVS}, author = {Mamata Bhattarai and Hedar Al-Terke and Kai Liu and Zhangmin Wan and Petri Kilpeläinen and Alistair W. T. King and Alexey Khakalo and Jiayun Xu and Chunlin Xu and Robin H. A. Ras and Bruno D. Mattos and Orlando J. Rojas}, doi = {10.1002/advs.202416686}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416686}, shortjournal = {Adv. Sci.}, title = {Wood biomolecules as agricultural adjuvants for effective suppression of droplet rebound from plant foliage}, volume = {12}, year = {2025}, }
• (2025). Modulating iron crystals with lattice chalcophile-siderophile elements for selective dechlorinations over hydrogen evolution. ADVS, 12(17), 2416663. (www)

  @article{ , abstract = {Selective dechlorination of organic chlorides over hydrogen evolution reaction (HER) remains a challenge because of their coincidence. Nanoscale zerovalent iron (nFe 0 ) draws a promising picture of in situ groundwater dechlorination, but its indiscriminate reactivity limits the application. Here, nFe 0 crystals are designed with electron shuttles and improved hydrophobic nature based on elemental chalcophile-siderophile characteristics, where chalcophile-siderophile S served as a bridge to allow impregnating nFe 0 crystals with weakly siderophile and strongly chalcophile Cu. Even impregnations of lattice chalcophile-siderophile elements into the nFe 0 crystals are evidenced at both intraparticle and individual-particle levels. The modulated Fe microenvironment and physicochemical properties broke the reactivity-selectivity-longevity-stability trade-off. Compared to nFe 0 , superhydrophobic Cu─S─nFe 0 with lattice expansion promoted dechlorination by 20-fold but inhibited HER by 150-fold, utilizing ≈80–100% electrons from the Fe 0 reservoir. This work demonstrates the concept of engineering nFe 0 lattice with tunable structure-property relationships, mimicking reductive dehalogenases by selectively interacting with halocarbon functional groups for efficient dehalogenation and sustainable groundwater remediation.}, archive = {J_ADVS}, author = {Xiaohong Hu and Qianhai Zhou and Du Chen and Zhongyuan Guo and Yiman Gao and Chaohuang Chen and Jie Hou and Vincent Noël and Daohui Lin and Lizhong Zhu and Jiang Xu}, doi = {10.1002/advs.202416663}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416663}, shortjournal = {Adv. Sci.}, title = {Modulating iron crystals with lattice chalcophile-siderophile elements for selective dechlorinations over hydrogen evolution}, volume = {12}, year = {2025}, }
• (2025). Thermal atoms facilitate intensity clipping between vectorial dual-beam generated by a single metasurface chip. ADVS, 12(17), 2416617. (www)

  @article{ , abstract = {Manipulating vector beams is pivotal in fields such as particle manipulation, image processing, and quantum communication. Flexibly adjusting the intensity distribution of these beams is crucial for effectively realizing these applications. This study introduces a vectorial dual-beam system utilizing thermal atoms as the medium for modulating the intensity profile of vector beams. A single metasurface is employed to generate both the control and signal vector beams, each with unique vectorial characteristics. The shaping of the signal beam profile is facilitated by the interaction with thermal atoms, which can be controlled by adjusting the control vector beam. This spatially selective absorption is a result of the thermal atoms' response to the varying polarizations within the vector beams. In this experiment, two distinct metasurface chips are fabricated to generate vector beams with doughnut-shaped and Gaussian-shaped intensity profiles. By adjusting the incident power and polarization state of the control light, the doughnut-shaped signal beams can be converted into a rotational dual-lobed pattern or the dimensions of the Gaussian-distributed signal beams can be modified. This study introduces a novel vector beam shaping technique by integrating metasurfaces with thermal atoms, offering significant promise for future applications requiring miniaturization, dynamic operation, and versatile control capabilities.}, archive = {J_ADVS}, author = {Chen Qing and Jialong Cui and Lishuang Feng and Dengke Zhang}, doi = {10.1002/advs.202416617}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416617}, shortjournal = {Adv. Sci.}, title = {Thermal atoms facilitate intensity clipping between vectorial dual-beam generated by a single metasurface chip}, volume = {12}, year = {2025}, }
• (2025). MTCH2 suppresses thermogenesis by regulating autophagy in adipose tissue. ADVS, 12(17), 2416598. (www)

  @article{ , abstract = {Stimulating adipose tissue thermogenesis has emerged as a promising strategy for combating obesity, with uncoupling protein 1 (UCP1) playing a central role in this process. However, the mechanisms that suppress adipose thermogenesis and energy dissipation in obesity are not fully understood. This study identifies mitochondrial carrier homolog 2 (MTCH2), an obesity susceptibility gene, as a negative regulator of energy homeostasis across flies, rodents, and humans. Notably, adipose-specific MTCH2 depletion in mice protects against high-fat-diet (HFD)-induced obesity and metabolic disorders. Mechanistically, MTCH2 deficiency promotes energy expenditure by stimulating thermogenesis in brown adipose tissue (BAT) and browning of subcutaneous white adipose tissue (scWAT), accompanied by upregulated UCP1 protein expression, enhanced mitochondrial biogenesis, and increased lipolysis in BAT and scWAT. Using integrated RNA sequencing and proteomic analyses, this study demonstrates that MTCH2 is a key suppressor of thermogenesis by negatively regulating autophagy via Bcl-2-dependent mechanism. These findings highlight MTCH2's critical role in energy homeostasis and reveal a previously unrecognized link between MTCH2, thermogenesis, and autophagy in adipose tissue biology, positioning MTCH2 as a promising therapeutic target for obesity and related metabolic disorders. This study provides new opportunities to develop treatments that enhance energy expenditure.}, archive = {J_ADVS}, author = {Xin-Yuan Zhao and Ben-Chi Zhao and Hui-Lin Li and Ying Liu and Bei Wang and An-Qi Li and Tian-Shu Zeng and Hannah Xiaoyan Hui and Jia Sun and Domagoj Cikes and Nele Gheldof and Jorg Hager and Jian-Xun Mi and D. Ross Laybutt and Yin-Yue Deng and Yan-Chuan Shi and G. Gregory Neely and Qiao-Ping Wang}, doi = {10.1002/advs.202416598}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416598}, shortjournal = {Adv. Sci.}, title = {MTCH2 suppresses thermogenesis by regulating autophagy in adipose tissue}, volume = {12}, year = {2025}, }
• (2025). Identification of NIBAN2-regulated RUNX2 alternative splicing presents novel strategies for antagonizing osteoporosis. ADVS, 12(17), 2416536. (www)

  @article{ , abstract = {Osteoporosis is characterized by excessive bone resorption and/or defects in bone formation. Identification of factors promoting osteoblast differentiation may provide potential targets for osteoporosis therapy. Through integral analyses of multiple datasets, NIBAN2 is found to be tightly associated with bone formation and osteoporosis. Indeed, NIBAN2 promotes osteoblast differentiation, and conditional Niban2 knockout in osteoblasts caused bone loss and insufficient mineralization. Mechanistically, NIBAN2 interacts with the HNRNPU-cored spliceosome complex and alters its components to regulate the alternative splicing of RUNX2 , which ultimately cause an increase in functional RUNX2 (nuclear localization sequence complete) but a decrease in dysfunctional RUNX2 (exon 6 exclusive) to reinforce osteoblast differentiation. Most importantly, NIBAN2 expression level negatively correlates with RUNX2 spliced isoforms and bone loss in osteoporosis patients. NIBAN2 overexpression rescues bone loss in ovariectomized mice. Thus, this research identifies NIBAN2-regulated RUNX2 alternative splicing as a potential mechanism of osteoblast differentiation that may present strategies for antagonizing osteoporosis.}, archive = {J_ADVS}, author = {Sheng Zhang and Zhiqiang Yang and Yuanlong Xie and Yufeng Zhang and Zhe Chen and Xuan Lv and Zhouming Deng and Zan Huang and Lin Cai and Renxiong Wei}, doi = {10.1002/advs.202416536}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416536}, shortjournal = {Adv. Sci.}, title = {Identification of NIBAN2-regulated RUNX2 alternative splicing presents novel strategies for antagonizing osteoporosis}, volume = {12}, year = {2025}, }
• (2025). Single test-based diagnosis and subtyping of pulmonary hypertension caused by fibrosing mediastinitis using plasma metabolic analysis. ADVS, 12(17), 2416454. (www)

  @article{ , abstract = {Pulmonary hypertension (PH) often leads to poor survival outcomes and encompasses diverse subtypes with distinct underlying causes. Specifically, PH resulting from fibrosing mediastinitis (FM-PH) presents significant diagnostic challenges due to nonspecific symptoms and overlap of clinical characterization with other PH subtypes, leading to frequent misdiagnosis and delayed treatment. Moreover, the complex diagnostic procedures impose a significant burden on FM-PH patients, many of whom already experience mobility difficulties. This study represents a single test-based diagnosis of FM-PH, using the plasma metabolites obtained through ferric particle-enhanced laser desorption/ionization mass spectrometry analysis. Distinct metabolic alterations in FM-PH are identified compared to healthy controls and other PH subtypes, achieving an area under the curve (AUC) of 0.987 for FM-PH diagnosis and 0.728 for differentiating FM-PH from other subtypes. By addressing existing gaps in diagnostic strategies, this research highlights the potential of metabolic analysis in elucidating the metabolic landscape of PH.}, archive = {J_ADVS}, author = {Yating Zhao and Chunmeng Ding and Hongling Su and Aqian Wang and Aiping Tang and Hongfan Zhao and Ya Ma and Min Zhang and Wanshan Liu and Ruimin Wang and Ziyue Zhang and Shouzhi Yang and Dingyitai Liang and Yida Huang and Kun Qian and Lin Huang and Qihua Fu and Yunshan Cao}, doi = {10.1002/advs.202416454}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416454}, shortjournal = {Adv. Sci.}, title = {Single test-based diagnosis and subtyping of pulmonary hypertension caused by fibrosing mediastinitis using plasma metabolic analysis}, volume = {12}, year = {2025}, }
• (2025). Decoding blastocystis-driven mechanisms in gut microbiota and host metabolism. ADVS, 12(17), 2416325. (www)

  @article{ , abstract = {Blastocystis , a prevalent eukaryotic microorganism in the gut microbiota, has emerged as a potential link between healthy diets and improved cardiometabolic health. Despite its genetic diversity and varied host interactions, Blastocystis is consistently associated with healthier dietary patterns and reduced risk of cardiometabolic diseases. Current evidence suggests that Blastocystis may influence host metabolism by modulating gut microbial composition, short-chain fatty acids (SCFAs) production, and immune cell differentiation. Moreover, its role in tryptophan metabolism provides intriguing insights into its potential impact on host signaling pathways. However, mechanistic evidence connecting Blastocystis to improved metabolic health remains limited. This perspective explores plausible pathways, including SCFAs-mediated signaling, tryptophan metabolism, and immune modulation, through which Blastocystis may exert its effects. A systematic research framework integrating axenic cultivation, in vitro co-culture systems, animal models, and multi-omics approaches is proposed to further elucidate these mechanisms and expand the understanding of Blastocystis in gut health and disease.}, archive = {J_ADVS}, author = {Lei Deng and Kevin SW Tan}, doi = {10.1002/advs.202416325}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416325}, shortjournal = {Adv. Sci.}, title = {Decoding blastocystis-driven mechanisms in gut microbiota and host metabolism}, volume = {12}, year = {2025}, }
• (2025). Gate-tunable dual-mode optoelectronic device for self-powered photodetector and optoelectronic synapse. ADVS, 12(17), 2416259. (www)

  @article{ , abstract = {In the advancing field of optoelectronics, multifunctional devices that integrate both detection and processing capabilities are increasingly desirable. Here, a gate-tunable dual-mode optoelectronic device based on a MoTe 2 /MoS 2 van der Waals heterostructure, designed to operate as both a self-powered photodetector and an optoelectronic synapse, is reported. The device leverages the photovoltaic effect in the MoTe 2 /MoS 2 PN junction for self-powered photodetection and utilizes trapping states at the SiO 2 /MoS 2 interface to emulate synaptic behavior. Gate voltage modulation enables precise control of the device's band structure, facilitating seamless switching between these two operational modes. The photodetector mode demonstrates broadband detection and fast response speed, while the optoelectronic synapse mode exhibits robust long-term memory characteristics, mimicking biological synaptic behavior. This dual functionality opens new possibilities for integrating neuromorphic computing into traditional optoelectronic systems, offering a potential pathway for developing advanced intelligent sensing and computing technologies.}, archive = {J_ADVS}, author = {Yi Ouyang and Chaoyi Zhang and Jun Wang and Zheng Guo and Zegao Wang and Mingdong Dong}, doi = {10.1002/advs.202416259}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416259}, shortjournal = {Adv. Sci.}, title = {Gate-tunable dual-mode optoelectronic device for self-powered photodetector and optoelectronic synapse}, volume = {12}, year = {2025}, }
• (2025). The hypoxia-associated high-risk cell subpopulation distinctly enhances the progression of glioma. ADVS, 12(17), 2416231. (www)

  @article{ , abstract = {Less-aggressive lower-grade gliomas (LGGs) frequently transform into glioblastoma (GBM). Most previous studies of gliomas have not focused on LGG-original high-risk subpopulations, which may be one of the most critical hallmarks of glioma progression. In this study, LGG samples are collected to perform single-cell sequencing (scRNA-seq) and identify a unique cell subpopulation marked by CDC20, KIF20A and PTTG1, correlating with poor survival in multiple cohorts. Importantly, the CDC20 + KIF20A + PTTG1 + cell subpopulation is strongly associated with transforming LGG to GBM according to scRNA-seq and multiplexed immunofluorescence staining assays. In vitro, ex vivo and in vivo investigations further hint that this cell subpopulation is critical to the proliferation and growth of gliomas, and is associated with the hypoxia core activation. Pharmaceutically and therapeutically, the inhibition of this cell subpopulation showed significant anti-tumor effects and effective enhancement of the Temozolomide treatment efficiency. These findings provide insights into the therapeutic strategies of glioma progression, highlighting promising ways to avoid early-stage gliomas developing into advanced gliomas.}, archive = {J_ADVS}, author = {Quan Wan and Xuechao Wu and Jinxu Zhou and Weiqi Wu and Yuanliang Cao and Cuiping Sun and Zheng Li and Zhicheng Gong and Hong Tang and Qilin Li and Junsheng Chu and Qing Wang and Kaisa Cui and Xiaojie Lu}, doi = {10.1002/advs.202416231}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416231}, shortjournal = {Adv. Sci.}, title = {The hypoxia-associated high-risk cell subpopulation distinctly enhances the progression of glioma}, volume = {12}, year = {2025}, }
• (2025). In situ stimuli transfer in multi-environment shape-morphing hydrogels based on the copolymer between spiropyran and acrylic acid. ADVS, 12(17), 2416173. (www)

  @article{ , abstract = {Smart hydrogels are considered as close mimics to the functions of biological entities. However, the stimuli-responsive performance of hydrogels is often limited by the slow diffusion process during water exchange with the surrounding environment. Here, a homogenous hydrogel composed of a water-soluble spiropyran covalently attached to the polyacrylic acid network is reported. This hydrogel demonstrates rapid and reversible shape-morphing behavior in air, underwater, or in oil. The mechanism involves the reversible protonation of spiropyran triggered by light stimuli. The release/capture of protons regulates the local proton concentration near the carboxyl groups in the polyacrylic acid network, distinguishing it from existing stimuli-responsiveness based on bulk water diffusion. The environment-independent shape-morphing performance of the unique in-situ stimuli transfer process, resulting in local water transfer amongst parts of a single piece of hydrogel is attributed. Eventually, light-controlled reversible actuation of the hydrogel is demonstrated, offering exciting possibilities for applications in flexible electronics, and soft actuators/robots.}, archive = {J_ADVS}, author = {Liwei Wu and Yiming Liu and Wenpei Yang and Zejun Liu and Cuiping Liu and Xiaomin Yuan and Lingling Zhang and Jie Ju and Xi Yao}, doi = {10.1002/advs.202416173}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416173}, shortjournal = {Adv. Sci.}, title = {In situ stimuli transfer in multi-environment shape-morphing hydrogels based on the copolymer between spiropyran and acrylic acid}, volume = {12}, year = {2025}, }
• (2025). Interfacial structural transformation for the synthesis of lead-free double perovskite nanocrystals. ADVS, 12(17), 2416046. (www)

  @article{ , abstract = {Lead-free halide double perovskite nanocrystals have emerged as one of the most promising alternatives to lead halide perovskite nanocrystals due to their non-toxicity, high stability, and outstanding optoelectronic properties. However, conventional synthesis methods often result in impurities due to increased constituent elements. In this study, an efficient water-oil biphasic interface-driven approach is introduced for synthesizing lead-free double perovskite nanocrystals, enabling controlled structural transformations from 0D to 2D and 3D structures. Starting from 0D Cs 3 BiBr 6 , a gradual cation exchange is achieved, forming 3D Cs 2 AgBiBr 6 . Real-time monitoring reveals the slow insertion of Ag + ions as the key to the structural transformation. The resulting Cs 2 AgBiBr 6 nanocrystals exhibit exceptional stability, maintaining their integrity for over 120 days under ambient conditions without significant degradation, showing no considerable material decomposition. Additionally, this method allows for the successful synthesis of 2D layered double perovskite Cs 4 ZnBi 2 Br 12 , which has not previously been reported in experimental studies. This biphasic synthesis strategy provides a universal and reliable method for producing high-quality double perovskite nanocrystals while offering valuable insights into their structural dynamics and properties.}, archive = {J_ADVS}, author = {Jun Liu and Anna A Vedernikova and Qi Xue and Huiying Gao and Xiuhui Xie and Jinfeng Xie and Elena V Ushakova and He Huang and Xiaohong Zhang}, doi = {10.1002/advs.202416046}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2416046}, shortjournal = {Adv. Sci.}, title = {Interfacial structural transformation for the synthesis of lead-free double perovskite nanocrystals}, volume = {12}, year = {2025}, }
• (2025). Dynamic ionic environment modulation for precise electrosynthesis of heterostructured bimetallic nanoparticles. ADVS, 12(17), 2415727. (www)

  @article{ , abstract = {Bimetallic heterostructures, including core–shell and Janus configurations, often offer unique electrocatalytic properties compared to monometallic nanoparticles. However, achieving precise control over both elemental composition and spatial arrangement within these structures remains a challenge. Here, an electrosynthesis method is introduced that enables the fabrication of heterostructured bimetallic nanoparticles with precise, independent control of their elemental distribution. By leveraging dual-channel scanning electrochemical cell microscopy (SECCM), the local ionic environment is dynamically modulated in situ, adjusting the deposition bias between channels to achieve selective electrodeposition. This approach allows temporal control over the solution conditions within the SECCM droplet, facilitating the synthesis of multi-layer core–shell nanoparticles with tunable thickness, number, and sequence of layers. This technique is demonstrated with Pt–Cu and Pt–Ni systems, synthesizing arrays of Cu@Pt and Pt@Cu core–shell structures, which are then screened for catalytic activity in hydrogen evolution (HER) and oxygen reduction (ORR) reactions. The high spatial resolution and on-demand control over the composition and structure make this method well-suitable for creating arrays of complex, multi-metallic heterostructures, which is expected to accelerate the discovery of advanced electrocatalytic materials, offering a platform for efficient and scalable electrocatalyst screening.}, archive = {J_ADVS}, author = {Heekwon Lee and Xun Zhan and Jamie H. Warner and Hang Ren}, doi = {10.1002/advs.202415727}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2415727}, shortjournal = {Adv. Sci.}, title = {Dynamic ionic environment modulation for precise electrosynthesis of heterostructured bimetallic nanoparticles}, volume = {12}, year = {2025}, }
• (2025). Polysilazane-coated films achieving record-high moisture barrier performance with sub-10 seconds densification using high-power VUV irradiation. ADVS, 12(17), 2415721. (www)

  @article{ , abstract = {An ultra-high moisture barrier compact SiN X film can be achieved from solution-processed perhydropolysilazane (PHPS) through vacuum ultraviolet (VUV) light exposure. This study investigates the photochemical reactions and photo-densification of PHPS-based barrier films under varying VUV light intensities, focusing on their effects on barrier performance. Photo-dehydrogenation of PHPS, involving N─H and Si─H bond cleavage, is efficient and unaffected by light intensity. However, photo-densification shows a strong dependence on light intensity, particularly above 290 mW cm −2 . Higher intensities enhance Si─N bond cleavage, alter film dynamics, and reduce free volume through bond rearrangement, facilitating rapid network reconstruction essential for ultra-high barrier properties. High-power VUV light at 309 mW cm −2 establishes a new benchmark for ultra-high barrier films via solution processing, achieving a record-low average water vapor transmission rate (WVTR) of 1.6 × 10 −5 g m −2 day −1 . Films are produced in under 10 s per layer, maintaining a barrier property of 3.8 × 10 −5 g m −2 day −1 . The optimal refractive index for the top 30 nm layer is 1.74–1.77, controlling WVTR within 10 −5 g m −2 day −1 , ensuring superior barrier performance for flexible electronic devices, such as perovskite solar cells and organic photovoltaics.}, archive = {J_ADVS}, author = {Luyang Song and He Sun and Yoshiyuki Suzuri}, doi = {10.1002/advs.202415721}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2415721}, shortjournal = {Adv. Sci.}, title = {Polysilazane-coated films achieving record-high moisture barrier performance with sub-10 seconds densification using high-power VUV irradiation}, volume = {12}, year = {2025}, }
• (2025). M6A modified miR-31-5p suppresses m1 macrophage polarization and autoimmune dry eye by targeting P2RX7. ADVS, 12(17), 2415341. (www)

  @article{ , abstract = {The dysregulation of the M1/M2 macrophage balance plays a pivotal role in autoimmune diseases. However, the interplay between microRNAs (miRNAs) and N6-methyladenosine (m6A) modulation in regulating this balance remains poorly understood. Here, a significant reduction in miR-31-5p levels is observed in the lacrimal glands of rabbit autoimmune dacryoadenitis and the peripheral blood mononuclear cells (PBMCs) of Sjögren's syndrome (SS) dry eye patients. Overexpression of miR-31-5p exhibits preventive and therapeutic effects on rabbit autoimmune dacryoadenitis. Further investigation revealed that miR-31-5p overexpression significantly restored the M1/M2 macrophage balance both in vivo and in vitro. Mechanistically, miR-31-5p directly targets the P2x7 receptor (P2RX7), leading to the inactivation of p38 mitogen-activated protein kinases (MAPK) signaling and reduced expression of M1 markers. Furthermore, methylated RNA immunoprecipitation and luciferase reporter assays demonstrated that fat mass and obesity-associated protein (FTO)-mediated m6A demethylation, which sustains pri-miR-31 stability, is responsible for the decreased miR-31-5p levels in autoimmune dry eye. Notably, PBMC samples from SS dry eye patients further support the link between reduced miR-31-5p levels and M1 macrophage activation observed in rabbits. Overall, these data highlight the critical role of the FTO/miR-31-5p/P2RX7/p38 MAPK axis in autoimmune inflammation, suggesting their potential as therapeutic targets for autoimmune dry eye.}, archive = {J_ADVS}, author = {Lu Zhao and Xuejia Li and Min Gao and Lin Liu and Binyun Ma and Xun Liu and Jiachen Zhang and Ruoxuan Liu and Bei Du and Ruihua Wei and Hong Nian}, doi = {10.1002/advs.202415341}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2415341}, shortjournal = {Adv. Sci.}, title = {M6A modified miR-31-5p suppresses m1 macrophage polarization and autoimmune dry eye by targeting P2RX7}, volume = {12}, year = {2025}, }
• (2025). Rapid blood clot removal via remote delamination and magnetization of clot debris. ADVS, 12(17), 2415305. (www)

  @article{ , abstract = {Micro/nano-scale robotic devices are emerging as a cutting-edge approach for precision intravascular therapies, offering the potential for highly targeted drug delivery. While employing micro/nanorobotics for stroke treatment is a promising strategy due to its ability to localize therapy and minimize drug dosage, current methods require prolonged treatment durations, increasing the risk of nerve tissue necrosis from extended hypoxia. Here a programmable colloidal microswarm capable of rapidly detaching blood clots from the vessel wall is developed, enabling swift recanalization without the need for complete clot degradation. More importantly, the detached clot debris, despite their random shapes, functions as magnetic “debris-robots” and can be efficiently propelled through helical swimming within flowing vessels, followed by retrieval using catheter suction. The entire process—including catheter delivery, controlled locomotion, clot detachment, and retrieval—can be completed in approximately half an hour, significantly saving time compared to the critical “Golden 6 hours” window for stroke treatment. This retrieval procedure greatly minimizes nanoparticle exposure in the bloodstream and lowers the risk of secondary clotting in distal vessels, marking a significant advancement in robotic-assisted thrombolysis.}, archive = {J_ADVS}, author = {Qinglong Wang and Ben Wang and Kai Fung Chan and Xin Song and Qianqian Wang and Fengtong Ji and Lin Su and Bonaventure Yiu Ming Ip and Ho Ko and Philip Wai Yan Chiu and Thomas Wai Hong Leung and Li Zhang}, doi = {10.1002/advs.202415305}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2415305}, shortjournal = {Adv. Sci.}, title = {Rapid blood clot removal via remote delamination and magnetization of clot debris}, volume = {12}, year = {2025}, }
• (2025). Advanced solid lubrication with COK-47: Mechanistic insights on the role of water and performance evaluation. ADVS, 12(17), 2415268. (www)

  @article{ , abstract = {Metal–organic framework (MOF) nanoparticles have attracted widespread attention as lubrication additives due to their tunable structures and surface effects. However, their solid lubrication properties have been rarely explored. This work introduces the positive role of moisture in solid lubrication in the case of a newly described Ti-based MOF (COK-47) powder. COK-47 achieves an 8.5-fold friction reduction compared to AISI 304 steel-on-steel sliding under room air. In addition, COK-47 maintains a similarly low coefficient of friction (0.1–0.2) on various counterbodies, including Al 2 O 3 , ZrO 2 , SiC, and Si 3 N 4 . Notably, compared to other widely studied MOFs (ZIF-8, ZIF-67) and 2D materials powder (MXene, TMD, rGO), COK-47 exhibits the lowest friction (≈0.1) under the same experimental settings. Raman spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, energy dispersive X-ray spectroscopy, scanning electron microscope, and transmission electron microscopy indicate that the tribofilm is an amorphous film obtained by hydrolysis of COK-47 in the air with moisture. Density functional theory further confirms that water catalyzes the decomposition of COK-47, a crucial step in forming the tribofilm. This study demonstrates the idea of utilizing MOF and water-assisted lubrication mechanisms. It provides new insights into MOF applications in tribology and highlights interdisciplinary contributions of mechanical engineering and chemistry.}, archive = {J_ADVS}, author = {Hanglin Li and Xudong Sui and Pablo Ayala and Edoardo Marquis and Hannah Rabl and Adrian Ertl and Pierluigi Bilotto and Yazhuo Shang and Jiusheng Li and Lu Xu and Maria Clelia Righi and Dominik Eder and Carsten Gachot}, doi = {10.1002/advs.202415268}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2415268}, shortjournal = {Adv. Sci.}, title = {Advanced solid lubrication with COK-47: Mechanistic insights on the role of water and performance evaluation}, volume = {12}, year = {2025}, }
• (2025). Mitigating doxorubicin-induced cardiotoxicity and enhancing anti-tumor efficacy with a metformin-integrated self-assembled nanomedicine. ADVS, 12(17), 2415227. (www)

  @article{ , abstract = {Doxorubicin (Dox) is a potent chemotherapeutic agent commonly used in cancer treatment. However, cardiotoxicity severely limited its clinical application. To address this challenge, a novel self-assembled nanomedicine platform, PMDDH, is developed for the co-delivery of Dox and metformin, an antidiabetic drug with cardioprotective and anti-tumor properties. PMDDH integrates metformin into a polyethyleneimine-based bioactive excipient (PMet), with Dox intercalated into double-stranded DNA and a hyaluronic acid (HA) coating to enhance tumor targeting. The PMDDH significantly improves the pharmacokinetics and tumor-targeting capabilities of Dox, while metformin enhances the drug's anti-tumor activity by downregulating programmed cell death ligand 1 (PD-L1) and activating the AMP-activated protein kinase (AMPK) signaling pathway. Additionally, the DNA component stimulates the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which synergizes with Dox-induced immunogenic cell death (ICD) to promote a robust anti-tumor immune response. PMDDH markedly reduces Dox-induced cardiotoxicity by preserving mitochondrial function, reducing reactive oxygen species (ROS) production, and inducing protective autophagy in cardiomyocytes. These findings position PMDDH as a promising dual-function nanomedicine that enhances the anti-tumor efficacy of Dox while minimizing its systemic toxicity, offering a safer and more effective alternative for cancer therapy.}, archive = {J_ADVS}, author = {Jiaxin Huang and Jieru Yang and Yuanying Yang and Xiaofeng Lu and Juan Xu and Shan Lu and Hong Pan and Wenhu Zhou and Wenqun Li and Songwen Chen}, doi = {10.1002/advs.202415227}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2415227}, shortjournal = {Adv. Sci.}, title = {Mitigating doxorubicin-induced cardiotoxicity and enhancing anti-tumor efficacy with a metformin-integrated self-assembled nanomedicine}, volume = {12}, year = {2025}, }
• (2025). High-speed 3D printing coupled with machine learning to accelerate alloy development for additive manufacturing. ADVS, 12(17), 2414880. (www)

  @article{ , abstract = {Developing novel alloys for 3D printing of metals is a time- and resource-intensive challenge. High-throughput 3D printing and material characterization protocols are used in this work to rapidly screen a wide range of chemical compositions and processing conditions. In situ, alloying of high-strength steel with pure Al in the targeted range of 0–10 wt.% and flexible adjustment of the volumetric energy input is performed to derive 20 individual alloy combinations. These conditions are characterized using large-area crystallographic analysis combined with chemistry and nanoindentation protocols. The significant influence of Al content and processing conditions on the constitutive material behavior of the metastable base alloy allowed for efficient exploration of the underlying process-structure-properties (PSP) relationships. The extracted PSP relations are discussed based on the dominant physical mechanisms observed in the samples. Furthermore, the microstructure-property relationship based on limited experimental data is supported by an explainable machine-learning approach.}, archive = {J_ADVS}, author = {Avinash Hariharan and Marc Ackermann and Stephan Koss and Ali Khosravani and Johannes Henrich Schleifenbaum and Patrick Köhnen and Surya R. Kalidindi and Christian Haase}, doi = {10.1002/advs.202414880}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414880}, shortjournal = {Adv. Sci.}, title = {High-speed 3D printing coupled with machine learning to accelerate alloy development for additive manufacturing}, volume = {12}, year = {2025}, }
• (2025). Altered neural activity in the mesoaccumbens pathway underlies impaired social reward processing in shank3-deficient rats. ADVS, 12(17), 2414813. (www)

  @article{ , abstract = {Social behaviors are crucial for human connection and belonging, often impacted by conditions like Autism Spectrum Disorder (ASD). The mesoaccumbens pathway (ventral tegmental area (VTA) to the nucleus accumbense (NAc)) plays a pivotal role in social behavior and is implicated in ASD. However, the impact of ASD-related mutations on social reward processing remains insufficiently explored. This study focuses on the Shank3 mutation, associated with a rare genetic condition and linked to ASD, examining its influence on the mesoaccumbens pathway during behavior, using the Shank3 -deficient rat model. Our findings indicate that Shank3 -deficient rats exhibit atypical social interactions, associated with altered neuronal activity of VTA dopaminergic and GABAergic neurons and reduced dopamine release in the NAc. Moreover, they demonstrate that manipulating VTA neuronal activity can normalize this behavior, providing insights into the effects of Shank3 mutations on social reward processing  and identifying a potential neural pathway for intervention.}, archive = {J_ADVS}, author = {Marie Barbier and Keerthi Thirtamara Rajamani and Shai Netser and Shlomo Wagner and Hala Harony-Nicolas}, doi = {10.1002/advs.202414813}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414813}, shortjournal = {Adv. Sci.}, title = {Altered neural activity in the mesoaccumbens pathway underlies impaired social reward processing in shank3-deficient rats}, volume = {12}, year = {2025}, }
• (2025). Mitigating strain localization via stabilized phase boundaries for strengthening multi-principal element alloys. ADVS, 12(17), 2414783. (www)

  @article{ , abstract = {Multi-principal element alloys (MPEA) demonstrate exceptional stability during rapid solidification, making them ideal candidates for additive manufacturing and other high-design-flexibility techniques. Unexpectedly, MPEA failure often mimics that of conventional metals, with strain localization along phase or grain boundaries leading to typical crack initiation. Most strategies aim at reducing strain localization either suppress the formation of high-energy sites or dissipate energy at crack tips to enhance toughness, rarely achieving a synergy of both. Inspired by the microstructure of mouse enamel, nanoscale body-centered cubic (BCC) and face-centered cubic (FCC) phases into MPEAs are introduced, stabilized at phase boundaries to provide ample plastic space for dislocation-mediated deformation. This approach overcomes the local hardening limitations of nanoscale alloys and harmonizes traditional toughening mechanisms—such as crack deflection, blocking, and bridging—to mitigate strain localization. These mechanisms impart the alloy with ultra-high tensile strength (≈1458.1 MPa) and ductility (≈21.2%) without requiring heat treatment. Atomic calculations reveal that partial atomic plane migration drives continuous dislocation transfer across phases. This study uncovers fundamental but latent mechanical mechanisms in MPEAs, advancing understanding of ultra-strong bioinspired alloys.}, archive = {J_ADVS}, author = {Jinliang Du and Shukuan Guo and Hangqi Feng and Weijie Li and Zhixin Huang and Zhongji Sun and Yunli Feng and Pei Wang and Ying Li}, doi = {10.1002/advs.202414783}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414783}, shortjournal = {Adv. Sci.}, title = {Mitigating strain localization via stabilized phase boundaries for strengthening multi-principal element alloys}, volume = {12}, year = {2025}, }
• (2025). MXene-supported single-atom electrocatalysts. ADVS, 12(17), 2414674. (www)

  @article{ , abstract = {MXenes, a novel member of the 2D material family, shows promising potential in stabilizing isolated atoms and maximizing the atom utilization efficiency for catalytic applications. This review focuses on the role of MXenes as support for single-atom catalysts (SACs) for various electrochemical reactions, namely the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), oxygen reduction reaction (ORR), carbon dioxide reduction reaction (CO 2 RR), and nitrogen reduction reaction (NRR). First, state-of-the-art characterization and synthesis methods of MXenes and MXene-supported SACs are discussed, highlighting how the unique structure and tunable functional groups enhance the catalytic performance of pristine MXenes and contribute to stabilizing SAs. Then, recent studies of MXene-supported SACs in different electrocatalytic areas are examined, including experimental and theoretical studies. Finally, this review discusses the challenges and outlook of the utilization of MXene-supported SACs in the field of electrocatalysis.}, archive = {J_ADVS}, author = {Jianan He and Joshua D. Butson and Ruijia Gu and Adrian Chun Minh Loy and Qining Fan and Longbing Qu and Gang Kevin Li and Qinfen Gu}, doi = {10.1002/advs.202414674}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414674}, shortjournal = {Adv. Sci.}, title = {MXene-supported single-atom electrocatalysts}, volume = {12}, year = {2025}, }
• (2025). Autophagy related 5 promotes mitochondrial fission and inflammation via HSP90-HIF-1α-mediated glycolysis in kidney fibrosis. ADVS, 12(17), 2414673. (www)

  @article{ , abstract = {Although significant progress in identifying molecular mediators of fibrosis is made, there is still controversy regarding the role and mechanism of autophagy in kidney fibrosis. Here, this study finds that autophagy related 5 (ATG5) is obviously increased in uric acid (UA), aristolochic acid (AA) and transforming growth factor- β 1 (TGF- β 1)-induced HK-2 cells, as well as in kidneys from patients with chronic kidney disease (CKD) and mice with hyperuricemic nephropathy (HN), aristolochic acid nephropathy (AAN) and unilateral renal ischemia-reperfusion injury (uIRI). Conditional deletion of ATG5 in HN, AAN and uIRI murine models significantly alleviated aberrant glycolysis, attenuated pathological lesions, and improved kidney function. Mechanistically, ATG5 mediates the binding between heat shock protein 90 (HSP90) and hypoxia-inducible factor 1alpha (HIF-1 α ), thereby enhancing the stability of HIF-1 α and further promoting the overactivation of glycolysis. Subsequently, the aberrant glycolysis facilitated the occurrence of mitochondrial fission and inflammatory response, thus leading to kidney fibrosis. Taken together, the study provides solid evidence supporting that persistent activation of ATG5 in kidney tubules promotes kidney fibrosis. The profibrotic function of ATG5 is related to the regulation on HSP90-HIF-1 α -mediated glycolysis, resulting in mitochondrial fission and renal inflammation. Thus, ATG5 may be a novel therapeutic target for kidney fibrosis.}, archive = {J_ADVS}, author = {Yan Hu and Jinqing Li and Hui Chen and Yingfeng Shi and Xiaoyan Ma and Yi Wang and Xialin Li and Qin Zhong and Yishu Wang and Daofang Jiang and Shougang Zhuang and Na Liu}, doi = {10.1002/advs.202414673}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414673}, shortjournal = {Adv. Sci.}, title = {Autophagy related 5 promotes mitochondrial fission and inflammation via HSP90-HIF-1α-mediated glycolysis in kidney fibrosis}, volume = {12}, year = {2025}, }
• (2025). Bio-based thermoplastic room temperature phosphorescent materials with closed-loop recyclability. ADVS, 12(17), 2414439. (www)

  @article{ , abstract = {Producing thermoplastic room temperature phosphorescent (RTP) materials with closed-loop recyclability from natural sources is an attractive approach but hard to achieve. Here, the study develops such RTP materials, Poly(TA)/Cell, by thermally polymerizing thioctic acid in the presence of cellulose. Specifically, polymerized thioctic acid poly(TA) forms strong hydrogen bonding interactions with CNF, promoting formation of molecular clusters between the oxygen-containing units. The as-formed clusters generate humidity- and excitation-sensitive green RTP emission. Red afterglow emission is also obtained by integrating Poly(TA)/Cell together with Rhodamine B (RhB) via an energy transfer process. Attributed to the thermoplastic properties, the as-obtained Poly(TA)/Cell can be thermally molded into flexible shapes with uncompromised RTP performance. Moreover, owing to the alkali-cleavable properties of the disulfide bond in Poly(TA)/Cell, thioctic acid and cellulose can be successfully recycled from Poly(TA)/Cell with a yield of 92.3% and 81.5%, respectively. As a demonstrator for potential utility, Poly(TA)/Cell is used to fabricate materials for information encryption.}, archive = {J_ADVS}, author = {Yuanyuan Qian and Yingxiang Zhai and Meng Li and Yinping Qin and Liang Lv and Tony D. James and Lidong Wang and Zhijun Chen}, doi = {10.1002/advs.202414439}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414439}, shortjournal = {Adv. Sci.}, title = {Bio-based thermoplastic room temperature phosphorescent materials with closed-loop recyclability}, volume = {12}, year = {2025}, }
• (2025). Efficient photothermoelectric conversion of CSS@BP/Bi2Te3 array for innovative aircraft attitude recognition. ADVS, 12(17), 2414438. (www)

  @article{ , abstract = {The realization of fast, simple and efficient flight attitude recognition is crucial for flight safety and control stability, but still faces challenges in new materials and technologies. Herein, a chloroplast-like selenium-doped copper sulfide@black phosphorus (CSS@BP) composite material is prepared by ultrasonic chemical synthesis using BP nanosheets to effectively absorb light energy and disperse CSS layers to promote rapid photothermal conversion, which shows the temperature change more than ≈40 °C and an excellent photothermal conversion efficiency of 68.9% at 405 nm, corresponding to the theoretical calculation results. Moreover, the CSS@BP/Bi 2 Te 3 photothermoelectric conversion array prepared by pulsed laser deposition coated Bi 2 Te 3 thermoelectric layer and laminated porous insulating polyimide film can generate rapid thermal current changes through irradiated/non-irradiated thermal gradients. Hence, a portable attitude recognition box (ARB) is assembled with a based CSS@BP/Bi 2 Te 3 array with a self-balancing laser and a current measurement chip that enables accurate attitude recognition through the bidirectional current generated by changes of irradiated area. Excitably, the ARB demonstrates over 86.47% accuracy without complex algorithms, showing excellent stability and robustness. Thus, this work offers an innovative solution for advancing photothermal materials and low-cost high-precision flight attitude sensing technologies.}, archive = {J_ADVS}, author = {Liangshutong Zhang and Yupu Zhang and Xinyu Li and Donghao Han and Wei Zhai and Jianyuan Wang}, doi = {10.1002/advs.202414438}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414438}, shortjournal = {Adv. Sci.}, title = {Efficient photothermoelectric conversion of CSS@BP/Bi2Te3 array for innovative aircraft attitude recognition}, volume = {12}, year = {2025}, }
• (2025). Ultrasound-assisted h2 transmitter enables hydrogen-gene therapy to prevent Anesthesia/Surgery-induced cognitive impairment. ADVS, 12(17), 2414397. (www)

  @article{ , abstract = {Postoperative cognitive dysfunction (POCD) frequently occurs after surgery, resulting in extended hospitalizations, higher healthcare expenses, and potential long-term cognitive impairment. Despite its significant impact, effective preventive and therapeutic strategies for POCD are still lacking. Neuroinflammation plays a crucial role in the pathogenesis of POCD. To address this, a H 2 emitter is developed that employs hydrogen-gene therapy facilitated by ultrasound, allowing for the repair of the neuroinflammatory microenvironment in a spatiotemporally controllable manner to effectively prevent anesthesia/surgery-induced cognitive impairment. Utilizing focused ultrasound, the blood–brain barrier can be opened in a controlled manner, enabling the efficient delivery of hydrogen emitters (HPPS) carrying siRNA to the site of neuroinflammation. On one hand, the hydrogen emitter effectively generates hydrogen to eliminate excess hydroxyl radicals; on the other hand, it utilizes siRNA to target and reduce tau protein phosphorylation. This targeted hydrogen-gene therapy strategy has been demonstrated in both mouse and rat postoperative models to significantly reduce neuroinflammation and improve postoperative spatial memory as well as object recognition. This study introduces a novel and effective strategy for preventing anesthesia/surgery-induced cognitive impairment and offering new insights for the treatment of other neuroinflammatory diseases.}, archive = {J_ADVS}, author = {Ruonan Zhan and Yan Fang and Chuyun Lou and Nan Chen and Xuan Mo and Bo Jiao and Mengke Liu and Yangxi Zhao and Weichen Xu and Huixiong Xu and Haohao Yin and Yi Zhang}, doi = {10.1002/advs.202414397}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414397}, shortjournal = {Adv. Sci.}, title = {Ultrasound-assisted h2 transmitter enables hydrogen-gene therapy to prevent Anesthesia/Surgery-induced cognitive impairment}, volume = {12}, year = {2025}, }
• (2025). Perfluorinated organosilicons enabling low-loss ferroelectric polymer composites for efficient energy storage and electroluminescence. ADVS, 12(17), 2414380. (www)

  @article{ , abstract = {Ferroelectric polymers for energy storage and conversions suffer from high energy losses. Despite great efforts in polymer composites with organic or inorganic fillers, limited successes are achieved with an often compromised dielectric constant ( K ). Here, a synthesized organic–inorganic hybrid—perfluorinated polyhedral oligomeric silsesquioxane (F-POSS) is presented for creating an ultralow-loss ferroelectric polymer composite. The incorporation of such perfluorinated organosilicons with unique “cage-arm” structure into the polymer not only modulates chain conformations but also inhibits charge transport through its wide bandgap and strong carrier-trapping capabilities. This results in a significant reduction of dielectric/conduction losses and enhanced electric breakdown strength while maintaining a high K , yielding a discharged energy density ( U e ) of 22.3 J cm −3 with a high efficiency ( η ) of 82.3%. The utility of F-POSS is further demonstrated in sandwiched devices (with high- K layers comprising quantum dots) that deliver a high U e of over 32 J cm −3 and a η > 80%, alongside an efficient alternating current–driven electroluminescence (luminance > 670 cd m −2 at 10 MV m −1 ). This work presents a facile strategy for achieving high- K , low-loss ferroelectric polymers, broadening their applications toward advanced energy storage and optoelectronic technologies.}, archive = {J_ADVS}, author = {Li Li and Zhubing Han and Hemant P Yennawar and Yunyun Cheng and Ting Han and Rui Feng and Yang Zhang and Guanghui Zhao and Qing Wang and Lijie Dong}, doi = {10.1002/advs.202414380}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414380}, shortjournal = {Adv. Sci.}, title = {Perfluorinated organosilicons enabling low-loss ferroelectric polymer composites for efficient energy storage and electroluminescence}, volume = {12}, year = {2025}, }
• (2025). Metal-organic framework-based tribovoltaic textile for human body signal monitoring. ADVS, 12(17), 2414086. (www)

  @article{ , abstract = {The pursuit of sustainable and portable direct current (DC) energy suppliers has ignited considerable interest in tribovoltaic nanogenerators (TVNGs), devices that harvest mechanical energy from the surrounding environment. However, the predominant focus in TVNG research has centered on rigid and silicon-based semiconductors that lack flexibility and are thus ill-suited for integration into common fabrics. Herein, a fully-textile TVNG with a simple design is introduced that enables the real-time monitoring of human physiological signals. The utilization of copper-benzenehexathiol (Cu-BHT), a conductive 2D metal-organic framework is proposed as a p-type semiconductor grown on fabric surfaces. The developed tribovoltaic textile (TVT) consists of Cu-BHT-modified cotton and metallic aluminum textile producing pure DC output due to self-rectification. With excellent flexibility and stability, Cu-BHT TVT is seamlessly integrated into textile-based accessories for continuous monitoring of human motion and respiration.}, archive = {J_ADVS}, author = {Yuanlong Li and Yinghong Wu and Alexander V Shokurov and Carlo Menon}, doi = {10.1002/advs.202414086}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414086}, shortjournal = {Adv. Sci.}, title = {Metal-organic framework-based tribovoltaic textile for human body signal monitoring}, volume = {12}, year = {2025}, }
• (2025). Electrosynthesis of atomically precise au nanoclusters. ADVS, 12(17), 2414057. (www)

  @article{ , abstract = {Innovation in synthesis methodologies is crucial for advancing the discovery of new materials. This work reports the electrosynthesis of a [Au 13 (4- t BuPhC≡C) 2 (Dppe) 5 ]Cl 3 nanocluster ( Au 13 NC) protected by alkynyl and phosphine ligands. From simple precursor, HAuCl 4 and ligands, the whole synthesis is driven by a constant potential in single electrolytic cell. X-ray crystallography determines its total structure. Control experiments, cyclic voltammetry, Proton Nuclear Magnetic Resonance ( 1 H NMR), gas chromatography, and other characterizations demonstrate that a critical tetranuclear Au(I) complex defines the electrochemical redox behavior of the reaction solution. The critical role of a base (e.g., triethylamine) is to suppress the hydrogen evolution reaction at the cathode, paving the way for the reduction of Au ions. To resolve the problem of over-reduction and deposition of Au on the cathode, pulsed electrolysis, which is specific to electrosynthesis is employed. It significantly improves the reaction rate and the isolated yield of Au 13 . To extend the application scope, another four NCs protected by different ligands, [Au 13 (4-FPhC≡C) 2 (Dppe) 5 ]Cl 3 , [Au 8 (2-CF 3 PhC≡C) 2 (Dppp) 4 ](PF 6 ) 2 , [Au 11 (Dppp) 5 ]Cl 3 , and [Au 8 (SC 2 H 4 Ph) 2 (Dppp) 4 ]Cl 2 are synthesized electrochemically, demonstrating the versatility of the strategy.}, archive = {J_ADVS}, author = {Jing Dong and Yawei Li and Yu Ding and Hai-Feng Su and Xiaoqin Cui and Yu-Xin Wang and Huan Li}, doi = {10.1002/advs.202414057}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2414057}, shortjournal = {Adv. Sci.}, title = {Electrosynthesis of atomically precise au nanoclusters}, volume = {12}, year = {2025}, }
• (2025). DAPK3 is essential for DBP-induced autophagy of mouse leydig cells. ADVS, 12(17), 2413936. (www)

  @article{ , abstract = {Dibutyl phthalate (DBP) has been widely used in the manufacture of various daily and industrial products. As one of the most important endocrine disruptors, DBP has male reproductive toxicity and can lead to testicular dysfunction. In view of the fact that Leydig cells are important functional and structural units in the testis, their damage will affect testicular function. However, the underlying mechanism of DBP-caused damage to mouse Leydig cells remains elusive. In the study, it is confirmed that DBP can promote the expression of death-associated protein kinase 3 (DAPK3), thereby inducing autophagy of mouse Leydig cells by using in vivo and in vitro experiments. Also, bioinformatics analysis and molecular biology experimental techniques are utilized to further demonstrate that DBP-induced upregulation of DAPK3 results from both the activated transcription by specific protein 2 (Sp2) and the decreased ubiquitination and degradation by parkin RBR E3 ubiquitin-protein ligase (PRKN). Interestingly, melatonin can inhibit both Sp2/DAPK3 and PRKN/DAPK3 signaling pathways by inhibiting oxidative stress, thereby alleviating DBP-induced autophagy of mouse Leydig cells. Overall, the study unravels a novel regulatory mechanism of DBP-induced autophagy of mouse Leydig cells and identifies DAPK3 as a potential therapeutic target for DBP-caused damage to the male reproductive system.}, archive = {J_ADVS}, author = {Si Yang and Ying Yang and Linlin Xu and Chaoju Hao and Jiaxiang Chen}, doi = {10.1002/advs.202413936}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2413936}, shortjournal = {Adv. Sci.}, title = {DAPK3 is essential for DBP-induced autophagy of mouse leydig cells}, volume = {12}, year = {2025}, }
• (2025). Constructing stable bifunctional electrocatalyst of Co─Co2Nb5O14 with reversible interface reconstitution ability for sustainable zn-air batteries. ADVS, 12(17), 2413796. (www)

  @article{ , abstract = {Transition metal and metal oxide heterojunctions have been widely studied as bifunctional oxygen reduction/evolution reaction (ORR/OER) electrocatalysts for Zn-air batteries, but the dynamic changes of transition metal oxides and the interface during catalysis are still unclear. Here, bifunctional electrocatalyst of Co─Co 2 Nb 5 O 14 is reported, containing lattice interlocked Co nanodots and Co 2 Nb 5 O 14 nanorods, which construct a strong metal-support interaction (SMSI) interface. Unlike the recognition that transition metals mainly serve as ORR active sites and metal oxides as OER active sites, it is found that both ORR/OER sites originate from Co 2 Nb 5 O 14 , while Co acts as an electronic regulatory unit. The SMSI interface promotes dynamic electron transfer between Co/Co 2 Nb 5 O 14 , and the reversible active sites of Nb 4+ /Nb 5+ realize bidirectional adsorption/migration of intermediates, thereby achieving dynamic reversible interface reconstitution. The electrocatalyst shows a high ORR half-wave potential of 0.84 V, a low OER overpotential of 296.3 mV, and great cycling stability over 30000 s. The ZAB shows a high capacity of 850.6 mA h·gZn −1 and can stably run 2050 cycles at 10 mA·cm⁻ 2 . Moreover, the constructed solid-state ZAB also shows leading cycling stability in comparison with the previous studies.}, archive = {J_ADVS}, author = {Shuo Chen and Liang Zhang and Zheng Liu and Yuehui Chen and Shouzhu Li and Yuanyuan Zhang and Junyu Chen and Jianhua Yan}, doi = {10.1002/advs.202413796}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2413796}, shortjournal = {Adv. Sci.}, title = {Constructing stable bifunctional electrocatalyst of Co─Co2Nb5O14 with reversible interface reconstitution ability for sustainable zn-air batteries}, volume = {12}, year = {2025}, }
• (2025). Extravasation of borrelia burgdorferi across the Blood–Brain barrier is an extremely rare event. ADVS, 12(17), 2413199. (www)

  @article{ , abstract = {Lyme disease, the most widespread tick-borne disease in North America, is caused by the bacterium Borrelia burgdorferi ( Bb ). Approximately 10–15% of infections result in neuroborreliosis, common symptoms of which include headaches, facial palsy, and long-term cognitive impairment. Previous studies of Bb dissemination focus on assessing Bb transmigration at static time points rather than analyzing the complex dynamic process of extravasation. Furthermore, current in vitro models lack crucial physiological factors such as flow, demonstrating a need for more robust models for studying Bb dissemination to understand its dynamics and mechanisms. Here, a 3D tissue-engineered microvessel model is used and fluorescently-labeled Bb is perfused to model vascular dissemination in non-tissue-specific (iEC) and brain-specific (iBMEC) microvessels while acquiring time-lapse images in real time. In iECs, extravasation involves two steps: adhesion to the endothelium and transmigration into the extracellular matrix, which can be modulated through glycocalyx degradation or inflammation. In contrast, Bb extravasation in iBMECs is an extremely rare event regardless of glycocalyx degradation or inflammation. In addition, circulating Bb do not induce endothelial activation in iECs or iBMECs, but induces barrier dysfunction in iECs. These findings provide a further understanding of Bb vascular dissemination.}, archive = {J_ADVS}, author = {Linus Wang and Zikai Xia and Anjan Singh and Bhavna Murarka and Nicole Baumgarth and John N. Aucott and Peter C. Searson}, doi = {10.1002/advs.202413199}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2413199}, shortjournal = {Adv. Sci.}, title = {Extravasation of borrelia burgdorferi across the Blood–Brain barrier is an extremely rare event}, volume = {12}, year = {2025}, }
• (2025). Three-channel wavefront shaping using non-interleaved spin-multiplexed plasmonic metasurfaces. ADVS, 12(17), 2413138. (www)

  @article{ , abstract = {Metasurfaces have garnered significant attention for their ability to manipulate light waves with multifunctional capabilities. Integrating independent wavefront controls within a single metasurface is essential to meet the growing demand for high-capacity, flat photonic devices. In this work, a versatile non-interleaved plasmonic metasurface platform utilizing quarter-wave plate meta-atoms for independent and simultaneous phase modulation of both co- and cross-polarized circularly polarized waves with subwavelength pixels, achieved by merging resonance and Pancharatnam-Berry phases is presented. We propose and experimentally validate three proof-of-concept designs operating in the near-infrared range: a beam deflector with three distinct reflection angles, a focusing metalens with three focal lengths, and a vortex beam generator with tunable topological charges. This plasmonic metasurface platform paves the way for customizable, multi-channel functionalities, advancing the development of integrated photonic devices with enhanced versatility.}, archive = {J_ADVS}, author = {Xingling Pan and Yadong Deng and Ziru Cai and Zhiming Chen and Yingtao Ding and Ziwei Zheng and Fei Ding}, doi = {10.1002/advs.202413138}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2413138}, shortjournal = {Adv. Sci.}, title = {Three-channel wavefront shaping using non-interleaved spin-multiplexed plasmonic metasurfaces}, volume = {12}, year = {2025}, }
• (2025). Revealing the origin and nature of the buried metal-substrate interface layer in Ta/Sapphire superconducting films. ADVS, 12(17), 2413058. (www)

  @article{ , abstract = {Despite constituting a smaller fraction of the qubit's electromagnetic mode, surfaces and interfaces can exert significant influence as sources of high-loss tangents, which brings forward the need to reveal properties of these extended defects and identify routes to their control. Here, we examine the structure and composition of the metal-substrate interfacial layer that exists in Ta/sapphire-based superconducting films. Synchrotron-based X-ray reflectivity measurements of Ta films, commonly used in these qubits, reveal an unexplored interface layer at the metal-substrate interface. Scanning transmission electron microscopy and core-level electron energy loss spectroscopy identified an intermixing layer (≈0.65 ± 0.05 nm) at the metal-substrate interface containing Al, O, and Ta atoms. Density functional theory modeling reveals that the structure and properties of the Ta/sapphire heterojunctions are determined by the oxygen content on the sapphire surface prior to Ta deposition for two atomic terminations of sapphire. Using a multimodal approach, we gained deeper insights into the interface layer between the metal and substrate, which suggests that the orientation of deposited Ta films depend on the surface termination of sapphire. The observed elemental intermixing at the metal-substrate interface influences the thermodynamic stability and electronic behavior of the film, which may also affect qubit performance.}, archive = {J_ADVS}, author = {Aswin k. Anbalagan and Rebecca Cummings and Chenyu Zhou and Junsik Mun and Vesna Stanic and Jean Jordan-Sweet and Juntao Yao and Kim Kisslinger and Conan Weiland and Dmytro Nykypanchuk and Steven L. Hulbert and Qiang Li and Yimei Zhu and Mingzhao Liu and Peter V. Sushko and Andrew L. Walter and Andi M. Barbour}, doi = {10.1002/advs.202413058}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2413058}, shortjournal = {Adv. Sci.}, title = {Revealing the origin and nature of the buried metal-substrate interface layer in Ta/Sapphire superconducting films}, volume = {12}, year = {2025}, }
• (2025). Cubic phase-inducible zwitterionic phospholipids improve the functional delivery of mRNA. ADVS, 12(17), 2413016. (www)

  @article{ , abstract = {Lipid nanoparticles (LNPs) are clinically advanced delivery systems for RNA. The extensively developed structure of ionizable lipids greatly contributes to the functional delivery of mRNA. However, endosomal escape is one of the severe biological barriers that continue to render this process inefficient (e.g., less than 10%). Although LNPs contain phospholipids, their role is poorly understood, and there have been few attempts to perform the chemical engineering required to improve their functionality. Herein, a cubic phase-inducible fusogenic zwitterionic phospholipid derived from 1,2-dioleoyl-3- sn -glycero-phosphoethanolamine (DOPE), DOPE-Cx is described, that is designed to correct this problem. The orientation of a zwitterionic head group of DOPE is engineered by attaching a series of hydrophobic moieties for zwitterionic intermolecular interaction with the head structure of phosphatidylcholine (PC), and this is followed by a lipid-phase transition into non-lamellar phases to facilitate membrane fusion-mediated endosomal escape. A structure–activity relationship study reveals that DOPE-Cx lipids with small hydrophobic chains induce cubic phases instead of a hexagonal phase when mixed with PC, which enhances the functional delivery of mRNA in the liver as opposed to the action of the typically utilized and naturally occurring phospholipids. Engineered functionalized phospholipids will be of great value for the therapeutic applications of mRNAs.}, archive = {J_ADVS}, author = {Kazuki Iwakawa and Rikako Sato and Mariko Konaka and Yuma Yamada and Hideyoshi Harashima and Yusuke Sato}, doi = {10.1002/advs.202413016}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2413016}, shortjournal = {Adv. Sci.}, title = {Cubic phase-inducible zwitterionic phospholipids improve the functional delivery of mRNA}, volume = {12}, year = {2025}, }
• (2025). Enhancing osteogenesis through bio-inspired recombinant coral protein galaxin by targeting mitochondrial metabolism and ATP production. ADVS, 12(17), 2412867. (www)

  @article{ , abstract = {Bio-inspired coral-derived scaffolds have been adopted for bone regeneration. However, these confront challenges such as the limited osteoinductive properties, environmental concerns, and ambiguous calcification mechanisms in coral proteins. In this study, the role of the recombinant coral protein galaxin in promoting osteogenesis is investigated. The observations reveal that recombinant galaxin regulates the mitochondrial metabolism in mouse pre-osteoblasts by interacting with the β subunit of ATP synthase. This ultimately promotes osteogenesis of pre-osteoblasts. Furthermore, galaxin is integrated with gelatin methacryloyl (GelMA) and assess the osteogenic potential of the resulting galaxin-GelMA composites in mouse mandibular defects. The observations emphasize the distinctive role of galaxin in regulating mitochondrial functionality and osteogenesis. Additionally, these provide prospective insights for further applications of bio-inspired recombinant coral proteins in regenerative medicine.}, archive = {J_ADVS}, author = {Fei Yu and Xing Zhao and Ting Jiang and Ningjuan Ouyang and Peilin Li and Wei Yang and Zhihe Zhao}, doi = {10.1002/advs.202412867}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412867}, shortjournal = {Adv. Sci.}, title = {Enhancing osteogenesis through bio-inspired recombinant coral protein galaxin by targeting mitochondrial metabolism and ATP production}, volume = {12}, year = {2025}, }
• (2025). Advancing allogeneic NK cell immunotherapy through microfluidic gene delivery. ADVS, 12(17), 2412544. (www)

  @article{ , abstract = {Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment, yet challenges such as manufacturing complexity, high costs, and safety concerns have spurred the development of alternatives like CAR-natural killer (NK) cell immunotherapies. CAR-NK cell therapies provide innate cytotoxicity with antigen-independent targeting, reducing safety risks while improving therapeutic efficacy. However, efficient genomic engineering and large-scale production of allogeneic NK cells remain significant obstacles. To address these challenges, a novel microfluidic gene delivery platform is developed, the Y-hydroporator, designed for allogeneic NK cell immunotherapy. This platform features a Y-shaped microchannel where NK cells experience rapid hydrodynamic stretching near the stagnation point, creating transient membrane discontinuities that facilitate the uptake of exogenous cargo. The Y-hydroporator achieves high delivery and transfection efficiency, processing ≈2 × 10 6 cells min −1 while maintaining long-term cell viability (>89%) and functionality. Using this platform, human primary CAR-NK cells and NKG2A-knockout NK cells are successfully generated by delivering anti-CD19 CAR mRNA and CRISPR/Cas9 ribonucleoproteins, respectively. These engineered NK cells demonstrated enhanced cytotoxicity, underscoring the potential of the Y-hydroporator as a transformative tool for advancing allogeneic NK cell-based immunotherapies.}, archive = {J_ADVS}, author = {Hyelee Kim and Mujin Lee and Bohwa Han and Jinho Kim and Duck Cho and Junsang Doh and Aram J. Chung}, doi = {10.1002/advs.202412544}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412544}, shortjournal = {Adv. Sci.}, title = {Advancing allogeneic NK cell immunotherapy through microfluidic gene delivery}, volume = {12}, year = {2025}, }
• (2025). YC-4-3, a novel glycogen synthase kinase 3β inhibitor, alleviates the endoplasmic reticulum stress of macrophages in primary immune thrombocytopenia. ADVS, 12(17), 2412515. (www)

  @article{ , abstract = {Primary immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by decreased platelet count and increased risk of hemorrhage, in which macrophages play an important role in the pathogenesis. This study aims to explore the effects of YC-4-3, the patented chemical synthesis of benzothiazepinone compounds (BTZs), a novel GSK-3β inhibitor (GSK-3βi), on macrophages in ITP. The expressions of GSK-3β in monocytes are tested. The effects of GSK-3βi (YC-4-3) on macrophages of ITP patients are examined and validated in passive and active murine models. Signal pathway enrichment analysis is performed. The interaction proteins of endoplasmic reticulum (ER) stress and GSK-3β are explored. The GSK-3β + cells in monocytes are increased in newly diagnosed ITP patients and decreased in treatment-response patients. YC-4-3 can restrain the proinflammatory differentiation, phagocytosis, and cytokine generation of macrophages and alleviate thrombocytopenia in ITP. YC-4-3 suppresses the PI3K/mTOR/Akt, NFκB/IκBα, and MAPK pathways, as well as the ER stress signal pathway. YC-4-3 directly interacts with the protein chaperone Bip. YC-4-3, a patented GSK-3βi, can modulate the inflammatory status of macrophages and improve the thrombocytopenia in ITP by directly interacting with ER stress response. YC-4-3 may be a novel potential therapeutic agent for ITP.}, archive = {J_ADVS}, author = {Pengcheng Xu and Lili Ji and Yanxia Zhan and Yang Ou and Xia Shao and Xibing Zhuang and Fanli Hua and Feng Li and Hao Chen and Yong Chu and Yunfeng Cheng}, doi = {10.1002/advs.202412515}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412515}, shortjournal = {Adv. Sci.}, title = {YC-4-3, a novel glycogen synthase kinase 3β inhibitor, alleviates the endoplasmic reticulum stress of macrophages in primary immune thrombocytopenia}, volume = {12}, year = {2025}, }
• (2025). The cerebrospinal fluid secretion rate increases in awake and freely moving rats but differs with experimental methodology. ADVS, 12(17), 2412469. (www)

  @article{ , abstract = {Cerebrospinal fluid (CSF) dynamics hold implications for neurological health. Despite its importance, accurate quantification of the CSF secretion rate remains a challenge due to methodological controversies and the influence of anesthesia. A novel technique is established to determine CSF dynamics in awake and freely moving rats, and the CSF secretion is quantified with three different methodologies. The CSF secretion rate is higher in awake rats than in anesthetized rats, the latter demonstrating no requirement for mechanical ventilation for optimal CSF quantification. The CSF secretion rate is ≈10-fold lower with the “direct method” than with the ventriculo-cisternal perfusion assay, although the relative acetazolamide-mediated reduction in CSF secretion is similar across three tested methods. The findings demonstrate the importance of awake models for optimal quantification of the absolute rate of CSF secretion but highlight the versatility of methodologies for the determination of relative changes in CSF secretion associated with inhibitors, age, sex, and various pathologies.}, archive = {J_ADVS}, author = {Trine L. Toft-Bertelsen and Beatriche L. Edelbo and Annette B. Steffensen and Sara D. Lolansen and Jonathan H. Wardman and Dennis B. Jensen and Nanna MacAulay}, doi = {10.1002/advs.202412469}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412469}, shortjournal = {Adv. Sci.}, title = {The cerebrospinal fluid secretion rate increases in awake and freely moving rats but differs with experimental methodology}, volume = {12}, year = {2025}, }
• (2025). Leveraging automated machine learning for environmental data-driven genetic analysis and genomic prediction in maize hybrids. ADVS, 12(17), 2412423. (www)

  @article{ , abstract = {Genotype, environment, and genotype-by-environment (G×E) interactions play a critical role in shaping crop phenotypes. Here, a large-scale, multi-environment hybrid maize dataset is used to construct and validate an automated machine learning framework that integrates environmental and genomic data for improved accuracy and efficiency in genetic analyses and genomic predictions. Dimensionality-reduced environmental parameters (RD_EPs) aligned with developmental stages are applied to establish linear relationships between RD_EPs and traits to assess the influence of environment on phenotype. Genome-wide association study identifies 539 phenotypic plasticity trait-associated markers (PP-TAMs), 223 environmental stability TAMs (Main-TAMs), and 92 G×E-TAMs, revealing distinct genetic bases for PP and G×E interactions. Training genomic prediction models with both TAMs and RD_EPs increase prediction accuracy by 14.02% to 28.42% over that of genome-wide marker approaches. These results demonstrate the potential of utilizing environmental data for improving genetic analysis and genomic selection, offering a scalable approach for developing climate-adaptive maize varieties.}, archive = {J_ADVS}, author = {Kunhui He and Tingxi Yu and Shang Gao and Shoukun Chen and Liang Li and Xuecai Zhang and Changling Huang and Yunbi Xu and Jiankang Wang and Boddupalli M. Prasanna and Sarah Hearne and Xinhai Li and Huihui Li}, doi = {10.1002/advs.202412423}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412423}, shortjournal = {Adv. Sci.}, title = {Leveraging automated machine learning for environmental data-driven genetic analysis and genomic prediction in maize hybrids}, volume = {12}, year = {2025}, }
• (2025). Berberine is a novel mitochondrial calcium uniporter inhibitor that disrupts MCU-EMRE assembly. ADVS, 12(17), 2412311. (www)

  @article{ , abstract = {The mitochondrial calcium uniporter (MCU) complex mediates Ca 2+ entry into mitochondria, which plays a crucial role in regulating cellular energy metabolism and apoptosis. Dysregulation of MCU is implicated in various diseases, such as neurodegenerative disorders, cardiac diseases, and cancer. Despite its importance, developing specific and clinically viable MCU inhibitors is challenging. Here, Berberine, a well-established drug with a documented safety profile, is identified as a potent MCU inhibitor through a virtual screening of an FDA-approved drug library. Berberine localizes within mitochondria and directly binds to the juxtamembrane loop domain of MCU. This binding disrupts the interaction of MCU with its essential regulator, EMRE, thereby inhibiting rapid Ca 2+ entry into the mitochondria. Notably, Berberine pretreatment reduces mitochondrial Ca 2+ overload and mitigates ischemia/reperfusion-induced myocardial injury in mice. These findings establish Berberine as a potent MCU inhibitor, offering a safe therapeutic strategy for diseases associated with dysregulated mitochondrial calcium homeostasis.}, archive = {J_ADVS}, author = {Haixin Zhao and Siqi Chen and Nian Cao and Wenjun Wu and Guangqin Liu and Jun Gao and Jiayi Chen and Ting Li and Dingyi Lu and Lingmin Zeng and Haizhen Zhu and Weina Zhang and Qing Xia and Teng Li and Tao Zhou and Xue-Min Zhang and Ai-Ling Li and Xin Pan}, doi = {10.1002/advs.202412311}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412311}, shortjournal = {Adv. Sci.}, title = {Berberine is a novel mitochondrial calcium uniporter inhibitor that disrupts MCU-EMRE assembly}, volume = {12}, year = {2025}, }
• (2025). Genome-wide association studies reveal the genetic architecture of ionomic variation in grains of tartary buckwheat. ADVS, 12(17), 2412291. (www)

  @article{ , abstract = {Tartary buckwheat ( Fagopyrum tataricum ) is esteemed as a medicinal crop due to its high nutritional and health value. However, the genetic basis for the variations in Tartary buckwheat grain ionome remains inadequately understood. Through genome-wide association studies (GWAS) on grain ionome, 52 genetic loci are identified associated with 10 elements undergoing selection. Molecular experiments have shown that the variation in FtACA13 ’s promoter (an auto-inhibited Ca 2+ -ATPase) is accountable for grain sodium concentration and salt tolerance, which underwent selection during domestication. FtYPQ1 (a vacuolar amino acid transporter) exhibits zinc transport activity, enhancing tolerance to excessive zinc stress and raising zinc accumulation. Additionally, FtNHX2 (a Na + /H + exchanger) positively regulates arsenic content. Further genomic comparative analysis of “20A1” (wild accession) and “Pinku” (cultivated accession) unveiled structural variants in key genes involved in ion uptake and transport that may result in considerable changes in their functions. This research establishes the initial comprehensive grain ionome atlas in Tartary buckwheat, which will significantly aid in genetic improvement for nutrient biofortification.}, archive = {J_ADVS}, author = {Zhirong Wang and Yuqi He and Mengyu Zhao and Xiang-Qian Liu and Hao Lin and Yaliang Shi and Kaixuan Zhang and Guijie Lei and Dili Lai and Tong Liu and Xiaoyang Peng and Jiayue He and Wei Li and Xiangru Wang and Sun-Hee Woo and Muriel Quinet and Alisdair R. Fernie and Xin-Yuan Huang and Meiliang Zhou}, doi = {10.1002/advs.202412291}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412291}, shortjournal = {Adv. Sci.}, title = {Genome-wide association studies reveal the genetic architecture of ionomic variation in grains of tartary buckwheat}, volume = {12}, year = {2025}, }
• (2025). Congruent and oriented crystallization of mixed Sn–Pb perovskite from the nano- to centimeter scale. ADVS, 12(17), 2412101. (www)

  @article{ , abstract = {Metal halide perovskites have garnered widespread attention for research and applications, thanks to their high adaptability in elemental composition and optoelectronic properties. The mixed Sn–Pb perovskite FASn 0.5 Pb 0.5 I 3 (FA + is formamidinium) features a narrow bandgap of 1.25 eV, appropriate for building tandem solar cells, but faces challenges in fabricating uniform, compact films having protected surfaces and scalable dimensions. Herein, a Lewis-base molecule trimethylthiourea (3T) is applied as a ligand to the FASn 0.5 Pb 0.5 I 3 system, and find that it favors binding to Sn 2+ over Pb 2+ . As a result, the tin and lead components crystallize congruently at the unit cell scale. The 3T ligand helps the FASn 0.5 Pb 0.5 I 3 crystal grains develop into regular shapes and micron sizes, so as to fill in the film thickness and closely contact the substrate. Also, slow evaporation of 3T during annealing inhibits surface defects and renders centimeter-wide film smoothness. Solar cells made of such FASn 0.5 Pb 0.5 I 3 films has achieved a power conversion efficiency of 21.5% and a fill factor of 81%. Eliminating methylammonium and a hole transport layer (HTL) from these solar cells substantially boosts their short-term and storage stabilities. These results will contribute to making streamlined, durable, and large-area perovskite tandem solar cells.}, archive = {J_ADVS}, author = {Donghao Miao and Zihao Zhu and Yuchen Ding and Qinyu Ning and Lei Cheng and Zheng Fang and Yi Chen and Guoping Qin and Yuedong Shi and Gang Li and Qixi Mi}, doi = {10.1002/advs.202412101}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412101}, shortjournal = {Adv. Sci.}, title = {Congruent and oriented crystallization of mixed Sn–Pb perovskite from the nano- to centimeter scale}, volume = {12}, year = {2025}, }
• (2025). Large-area conductor-loaded PDMS flexible composites for wireless and chipless electromagnetic multiplexed temperature sensors. ADVS, 12(17), 2412066. (www)

  @article{ , abstract = {Capacitive dielectric temperature sensors based on polydimethylsiloxane (PDMS) loaded with 10 vol% of inexpensive, commercially-available conductive fillers including copper, graphite, and milled carbon fiber (PDMS-CF) powders are reported. The sensors are tested in the range of 20–110 °C and from 0.5 to 200 MHz, with enhanced sensitivity from 20 to 60 °C, and a relative response of 85.5% at 200 MHz for PDMS-CF capacitors. PDMS-CF capacitors are interrogated as a sensing element in wirelessly coupled chipless resonant coils tuned to 6.78 MHz with a response in the resonant frequency ( f r ) of the sensor, demonstrating an average sensitivity of 0.38% °C −1 , a 40x improvement over a pristine PDMS capacitive sensor and outperforms state-of-the-art frequency-domain radio frequency temperature sensors. Exploiting its high sensitivity, the wireless sensing platform is interrogated using a low-cost, portable, and open-source NanoVNA demonstrating a relative response in f r of 48.5%, good agreement with instrumentation-grade vector network analyzers (VNAs) and negligible change in performance at a range of reading distances and humidities. Finally, a wireless tag is demonstrated with rapid, reversible dynamic response to changes in temperature, as well as the in the first scalable, multiplexed array of chipless sensors for spatial temperature detection.}, archive = {J_ADVS}, author = {Benjamin King and Nikolas Bruce and Mahmoud Wagih}, doi = {10.1002/advs.202412066}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2412066}, shortjournal = {Adv. Sci.}, title = {Large-area conductor-loaded PDMS flexible composites for wireless and chipless electromagnetic multiplexed temperature sensors}, volume = {12}, year = {2025}, }
• (2025). P21-activated kinase 2 as a novel target for ventricular tachyarrhythmias associated with cardiac adrenergic stress and hypertrophy. ADVS, 12(17), 2411987. (www)

  @article{ , abstract = {Ventricular arrhythmias associated with cardiac adrenergic stress and hypertrophy pose a significant clinical challenge. We explored ventricular anti-arrhythmic effects of P21-activated kinase 2 (Pak2), comparing in vivo and ex vivo cardiomyocyte-specific Pak2 knockout (Pak2 cko ) or overexpression (Pak2 ctg ) murine models, under conditions of acute adrenergic stress, and hypertrophy following chronic transverse aortic constriction (TAC). Pak2 was downregulated 5 weeks following the latter TAC challenge. Cellular physiological, optical action potential and Ca 2+ transient, measurements, demonstrated increased incidences of triggered ventricular arrhythmias, and prolonged action potential durations (APD) and altered Ca 2+ transients with increases in their beat-to beat variations, in Pak2 cko hearts. Electron microscopic, proteomic, and molecular biological methods revealed a mitochondrial localization of stress-related proteins on proteomic and phosphoproteomic analyses, particularly in TAC stressed Pak2 cko mice. They further yielded accompanying evidence for mitochondrial oxidative stress, increased reactive oxygen species (ROS) biosynthesis, reduced mitochondrial complexes I-V, diminished ATP synthesis and elevated NADPH oxidase 4 (NOX4) levels. Pak2 overexpression and the novel Pak2 activator JB2019A ameliorated these effects, enhanced cardiac function and decreased the frequencies of triggered ventricular arrhythmias. Pak2 activation thus protects against ventricular arrhythmia associated with cardiac stress and hypertrophy, through unique mechanisms offering potential novel therapeutic anti-arrhythmic targets.}, archive = {J_ADVS}, author = {Tao Li and Ting Liu and Yan Wang and Yangpeng Li and Leiying Liu and James Bae and Yu He and Xian Luo and Zhu Liu and Tangting Chen and Xianhong Ou and Dan Zhang and Huan Lan and Juyi Wan and Yan Wei and Fang Zhao and Xin Wang and Christopher L.-H. Huang and Chunxiang Zhang and Ming Lei and Xiaoqiu Tan}, doi = {10.1002/advs.202411987}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2411987}, shortjournal = {Adv. Sci.}, title = {P21-activated kinase 2 as a novel target for ventricular tachyarrhythmias associated with cardiac adrenergic stress and hypertrophy}, volume = {12}, year = {2025}, }
• (2025). Orally administered functional polyphenol-nanozyme-armored probiotics for enhanced amelioration of intestinal inflammation and microbiota dysbiosis. ADVS, 12(17), 2411939. (www)

  @article{ , abstract = {Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme-based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. Despite significant advancements, developing a green and safe coating technology that functionalizes probiotics with nanozymes while preserving the activity of both components remains a challenge. To address this, chitosan-modified epigallocatechin gallate (EGCG-CS, EC)is synthesized, leveraging the intrinsic adhesive and coordination properties of polyphenols to capture gold nanozymes (AuNPs), forming ECA complexes that enhance nanozyme activity. When coated onto Escherichia coli Nissle 1917 (EcN), the resulting ECA@EcN system effectively scavenged reactive oxygen species (ROS), improving probiotic viability and promoting colon accumulation. Mechanistically, ECA protected EcN by suppressing the activation of the Flagellar Assembly and Branched-Chain Amino Acid Synthesis pathways, ultimately alleviating inflammation and modulating intestinal microbial communities to relieve IBD symptoms. Given the biocompatibility of its components and the environmentally friendly assembly approach, this polyphenol-nanozyme-armored probiotic system represents a promising platform for IBD treatment.}, archive = {J_ADVS}, author = {Yong Zhu and Ziqu Fang and Jie Bai and Longhui Wang and Jiaqing Chen and Zehua Zhang and Qiang Wang and Weiwei Sheng and Xueyin Pan and Zhenyuan Gao and Dengqiu Xu and Pengkai Wu and Beicheng Sun}, doi = {10.1002/advs.202411939}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2411939}, shortjournal = {Adv. Sci.}, title = {Orally administered functional polyphenol-nanozyme-armored probiotics for enhanced amelioration of intestinal inflammation and microbiota dysbiosis}, volume = {12}, year = {2025}, }
• (2025). SIRT3-mediated deacetylation of DRP1K711 prevents mitochondrial dysfunction in parkinson's disease. ADVS, 12(17), 2411235. (www)

  @article{ , abstract = {Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD). Aberrant mitochondrial fission induced by dynamin-related protein 1 (DRP1) causes mitochondrial dysfunction in dopaminergic (DA) neurons. However, the mechanism of DRP1 activation and its role in PD progression remain unclear. In this study, Mass spectrometry analysis is performed and identified a significant increased DRP1 acetylation at lysine residue 711 (K711) in the mitochondria under oxidative stress. Enhanced DRP1 K711 acetylation facilitated DRP1 oligomerization, thereby exacerbating mitochondrial fragmentation and compromising the mitochondrial function. DRP1 K711 acetylation also affects mitochondrial DRP1 recruitment and fission independent of canonical S616 phosphorylation. Further analysis reveals the critical role of sirtuin (SIRT)-3 in deacetylating DRP1 K711 , thereby regulating mitochondrial dynamics and function. SIRT3 agonists significantly inhibit DRP1 K711 acetylation, rescue DA neuronal loss, and improve motor function in a PD mouse model. Conversely, selective knockout of SIRT3 in DA neurons exacerbates DRP1 K711 acetylation, leading to increased DA neuronal damage, neuronal death, and worsened motor dysfunction. Notably, this study identifies a novel mechanism involving aberrant SIRT3-mediated DRP1 acetylation at K711 as a key driver of mitochondrial dysfunction and DA neuronal death in PD, revealing a potential target for PD treatment.}, archive = {J_ADVS}, author = {Ye Xi and Kai Tao and Xiaomin Wen and Dayun Feng and Zifan Mai and Hui Ding and Honghui Mao and Mingming Wang and Qian Yang and Jie Xiang and Jie Zhang and Shengxi Wu}, doi = {10.1002/advs.202411235}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2411235}, shortjournal = {Adv. Sci.}, title = {SIRT3-mediated deacetylation of DRP1K711 prevents mitochondrial dysfunction in parkinson's disease}, volume = {12}, year = {2025}, }
• (2025). TRAF3IP3 induces ER stress-mediated apoptosis with protective autophagy to inhibit lung adenocarcinoma proliferation. ADVS, 12(17), 2411020. (www)

  @article{ , abstract = {TNF receptor-associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation. However, the specific effects and molecular mechanisms of TRAF3IP3 on the progression of lung adenocarcinoma (LUAD) remains poorly understood. This study reveals TRAF3IP3 is upregulated in several tumor tissues but exclusively decreased in LUAD and Lung squamous cell carcinoma (LUSC) tissues, consequential in a favorable overall survival (OS) in LUAD rather than LUSC. Herein, it is reported that TRAF3IP3 can suppress cell proliferation and promote the apoptosis rate of LUAD cells by inducing excessive ER stress-related apoptosis. Importantly, TRAF3IP3 triggers ER stress via the PERK/ATF4/CHOP pathway, accompanied by stimulated ER stress-induced cytoprotective autophagy in LUAD cells. Through IP-MS analysis, STRN3 is identified as a direct downstream interactor with TRAF3IP3 and corroborated to regulate ER stress positively. Mechanistically, TRAF3IP3 facilitates the recruitment of STRN3 to the ER lumen through its transmembrane domain and fulfills its functional role in ER stress in an STRN3-dependent manner in LUAD cells. Given its dual role in orchestrating ER stress-associated apoptosis and autophagy in LUAD cell fate determination, the importance of TRAF3IP3 is highlighted as novel therapeutic target for LUAD treatment.}, archive = {J_ADVS}, author = {Guang Zhao and Jun Qi and Fang Li and Haotian Ma and Rui Wang and Xiuyi Yu and Yufei Wang and Sida Qin and Jie Wu and Chen Huang and Hong Ren and Boxiang Zhang}, doi = {10.1002/advs.202411020}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2411020}, shortjournal = {Adv. Sci.}, title = {TRAF3IP3 induces ER stress-mediated apoptosis with protective autophagy to inhibit lung adenocarcinoma proliferation}, volume = {12}, year = {2025}, }
• (2025). NF2 is essential for human endoderm development. ADVS, 12(17), 2410909. (www)

  @article{ , abstract = {Vertebrate embryogenesis requires the precisely timed specification of 3 germ cell layers— ectoderm, mesoderm, and endoderm— which give rise to tissues and organs in the developing organism. The tumor suppressor gene NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor (Nf2) is expressed in all 3 germ layers during mouse development and its homozygous deletion causes embryonic lethality. People with heterozygous NF2 mutations typically develop Schwann cell tumors, especially vestibular schwannoma, but the specific role of NF2 in human embryonic development is unclear. Here, human induced pluripotent stem cells (hiPSCs) are used to demonstrate that NF2 is essential for endoderm specification and formation in humans. Although endoderm differentiation is not impaired in hiPSCs with heterozygous NF2 mutation, NF2 knockout (NF2 −/− ) abolished the capacity to form endoderm in vitro, confirmed by loss of expression of endoderm-related genes and proteins, or teratomas in vivo. This defect is mediated by the nuclear translocation of yes-associated protein 1 (YAP1), a transcription co-activator regulating lineage fate via the Hippo pathway and subsequent YAP1-mediated shutdown of Activin/Nodal signaling. Endoderm formation can be rescued via YAP1 knockdown or forced re-expression of NF2 in NF2 −/− cells. Taken together, the essential role of NF2 during endoderm specification in human embryogenesis as a regulator of YAP1 is reported.}, archive = {J_ADVS}, author = {Minjin Jeong and Dongjun Han and Preetida Bhetariya and D. Bradley Welling and Miodrag Stojkovic and Konstantina M. Stankovic}, doi = {10.1002/advs.202410909}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2410909}, shortjournal = {Adv. Sci.}, title = {NF2 is essential for human endoderm development}, volume = {12}, year = {2025}, }
• (2025). The nuclear receptor NR1B1/RARα arrests the differentiation of anti-tumor effector cytotoxic t cells. ADVS, 12(17), 2410241. (www)

  @article{ , abstract = {NR1B1/RARα expression is dynamically regulated in cytotoxic lymphocytes (CTLs) in tumors, but the importance of its expression in anti-tumor CTLs remains unknown. RARα gene expression is upregulated in CTLs in tumor microenvironments (TME), but its protein expression is downregulated by retinoic acid. The role of RARα expression in regulating anti-tumor effector CTL (Teff) differentiation is reported. Mice that over-express RARα in T cells are defective in early Teff differentiation and fail to populate tumors. In contrast, RARα-deficient CTLs are hyper-active in making tumor-populating Teff cells, suggesting that RARα represses Teff differentiation. Moreover, RARα negatively controls the trafficking receptor switch from the lymphoid to an effector type. Generation of chimeric antigen receptor (CAR) T cells with reduced RARα expression produces highly effective CAR T cells with enhanced anti-tumor cytotoxicity. Mechanistically, upregulated RARα expression decreases the nuclear histone acetylase (HAT) activity, required for TCF1 to BATF transcription factor and trafficking switches during Teff differentiation. Additionally, RARα and BATF closely associate with each other on Teff-associated genes on the chromatin for possible cross-regulation. In sum, T cell-expressed RARα is identified as a novel negative regulator and potential target of intervention in promoting anti-cancer T cell immunity.}, archive = {J_ADVS}, author = {Patrick Niekamp and Ryun Hee Kim and Adithyan Jayaraman and Nils Klement and Raymond Kostlan and Chang H. Kim}, doi = {10.1002/advs.202410241}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2410241}, shortjournal = {Adv. Sci.}, title = {The nuclear receptor NR1B1/RARα arrests the differentiation of anti-tumor effector cytotoxic t cells}, volume = {12}, year = {2025}, }
• (2025). Osteosarcoma cell-derived migrasomes promote macrophage m2 polarization to aggravate osteosarcoma proliferation and metastasis. ADVS, 12(17), 2409870. (www)

  @article{ , abstract = {The local tumor microenvironment (TME) of osteosarcoma (OS) includes several tumor niches that control tumor growth and cell extravasation. Migrasomes are recently discovered extracellular vesicles produced during cell migration. Herein, the results show OS cell production of migrasomes in vivo and in vitro. Osteosarcoma cell-derived migrasomes (OCDMs) aggravate OS proliferation and metastasis, and impeding OCDM formation alleviates the malignant progression of OS. Further studies revealed that migrasome-associated nanoparticles (MANPs) are the functional unit of OCDMs and that OCDMs promote M2 polarization of macrophages in the TME in a MANPs-dependent manner. Moreover, milk fat globule-EGF factor 8 (MFGE8) in OCDMs is identified as a key protein that enhances phagocytosis to promote the M2 polarization of macrophages. Overall, the results reveal that OCDMs enhance the M2 polarization of macrophages in the TME to aggravate OS progression via MFGE8. These findings may guide the development of OCDM-modulating OS therapies.}, archive = {J_ADVS}, author = {Wanshun Liu and Lei Li and Xiaoming Bai and Mengxue Zhang and Wei Lv and Yongbin Ma and Yuzhi Sun and Hongjing Zhang and Qing Jiang and Qingqiang Yao and Zhi-Yuan Zhang}, doi = {10.1002/advs.202409870}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2409870}, shortjournal = {Adv. Sci.}, title = {Osteosarcoma cell-derived migrasomes promote macrophage m2 polarization to aggravate osteosarcoma proliferation and metastasis}, volume = {12}, year = {2025}, }
• (2025). Dynamics of cell fate decisions during chemically induced multi-lineage trans-differentiation at single-cell level. ADVS, 12(17), 2409642. (www)

  @article{ , abstract = {Cell trans-differentiation offers a powerful means to manipulate cell identities. By exposing cells to a combination of small molecules (SMs), cell trans-differentiation can be induced in a simple and cost-effective manner. However, a comprehensive atlas detailing chemical-induced cell trans-differentiation across multiple cell fates has yet to be established. In this study, the underlying mechanisms of trans-differentiation is investigated and constructed an in-depth single-cell atlas of this process. The time-course trajectory is demonstrated for trans-differentiation of mouse embryonic fibroblasts (MEFs) into multiple cell lineages including epithelial, neural, extraembryonic endoderm like (XEN-like) cells, and endothelial cells, when induced by SMs cocktail 6TCF (E616452, tranylcypromine, CHIR99021, and forskolin). These trans-differentiated cells closely resemble various somatic cell types in the fetus. It is found that trans-differentiation is marked by dynamic shifts in entropy and the cell cycle during cell fate transitions. A common intermediate feature is revealed characterized by high ribosomal gene expression. This study combines high-resolution landscape with comparative analyses of trans-differentiation dynamics, providing new insights into the complex mechanisms driving cell fate determination in vitro. Future study shall explore the applicability of the model in human cell trans-differentiation.}, archive = {J_ADVS}, author = {Weigao E and Lijiang Fei and Jingjing Wang and Xinru Wang and Renying Wang and Xueyi Wang and Peijing Zhang and Jianhui Chen and Junqing Wu and Mengmeng Jiang and Daosheng Huang and Danmei Jia and Guoji Guo and Xiaoping Han}, doi = {10.1002/advs.202409642}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2409642}, shortjournal = {Adv. Sci.}, title = {Dynamics of cell fate decisions during chemically induced multi-lineage trans-differentiation at single-cell level}, volume = {12}, year = {2025}, }
• (2025). Advances in nano-immunomodulatory systems for the treatment of acute kidney injury. ADVS, 12(17), 2409190. (www)

  @article{ , abstract = {Acute kidney injury (AKI) occurs when there is an imbalance in the immune microenvironment, leading to ongoing and excessive inflammation. Numerous immunomodulatory therapies have been suggested for the treatment of AKI, the current immunomodulatory treatment delivery systems are suboptimal and lack efficiency. Given the lack of effective treatment, AKI can result in multi-organ dysfunction and even death, imposing a significant healthcare burden on both the family and society. This underscores the necessity for innovative treatment delivery systems, such as nanomaterials, to better control pathological inflammation, and ultimately enhance AKI treatment outcomes. Despite the modification of numerous immunomodulatory nanomaterials to target the AKI immune microenvironment with promising therapeutic results, the literature concerning their intersection is scarce. In this article, the pathophysiological processes of AKI are outlined, focusing on the immune microenvironment, discuss significant advances in the comprehension of AKI recovery, and describe the multifunctionality and suitability of nanomaterial-based immunomodulatory treatments in managing AKI. The main obstacles and potential opportunities in the swiftly advancing research field are also clarified.}, archive = {J_ADVS}, author = {Chenli Zhang and Zeli Xiang and Pengfei Yang and Ling Zhang and Jun Deng and Xiaohui Liao}, doi = {10.1002/advs.202409190}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2409190}, shortjournal = {Adv. Sci.}, title = {Advances in nano-immunomodulatory systems for the treatment of acute kidney injury}, volume = {12}, year = {2025}, }
• (2025). Transcriptomic profiling unveils EDN3+ meningeal fibroblasts as key players in sturge-weber syndrome pathogenesis. ADVS, 12(17), 2408888. (www)

  @article{ , abstract = {Sturge-Weber syndrome (SWS) is characterized by leptomeningeal vascular malformation, resulting in significant risks of life-threatening seizures and strokes. The current absence of specific treatments underscores the need to define the molecular and cellular mechanisms that drive the progression of SWS. Here, the transcriptome of 119 446 cells isolated from both malformed tissues and peri-lesion tissues from the brains of patients with SWS is examined. This comprehensive analysis finds a complex landscape of cell heterogeneity and distinct cell substate associated with the evolution of this disease are revealed. Notably, a unique fibroblast cluster and molecular mechanism are identified that contribute to the development of SWS. These findings not only expand the understanding of SWS but also open up promising avenues for therapeutic interventions.}, archive = {J_ADVS}, author = {Daosheng Ai and Tianyue Ming and Xiaoli Li and Shu Wang and Zhanying Bi and Jinyi Zuo and Zizhang Cheng and Weijin Sun and Mingguo Xie and Fengzhi Li and Xiongfei Wang and Xueling Qi and Guoming Luan and Woo-ping Ge and Yuguang Guan}, doi = {10.1002/advs.202408888}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2408888}, shortjournal = {Adv. Sci.}, title = {Transcriptomic profiling unveils EDN3+ meningeal fibroblasts as key players in sturge-weber syndrome pathogenesis}, volume = {12}, year = {2025}, }
• (2025). Novel solution-processed Fe2O3/WS2 hybrid nanocomposite dynamic memristor for advanced power efficiency in neuromorphic computing. ADVS, 12(17), 2408133. (www)

  @article{ , abstract = {Non-volatile memory (NVM) based neuromorphic computing, which is inspired by the human brain, is a compelling paradigm in regard to building energy-efficient computing hardware that is tailored for artificial intelligence. However, the current state of the art NVMs are facing challenges with low operating voltages, energy efficiencies, and high densities in order to meet the new computing system beyond Moore's law. It is therefore necessary to develop novel hybrid materials with controlled compositional dynamics is crucial for initiating memristor devices capable of low-power operations. This study validates the effectiveness of Ag/Fe 90 W 10 /Pt hybrid nanocomposite memristor devices, demonstrating superior performance including ultra-low voltage operation, high stability, reproducibility, exceptional endurance (10 5 cycles), environmental resilience, and low energy consumption of 0.072 pJ. Moreover, the memristor exhibits the ability to emulate essential biological synaptic mechanisms. The resistive switching phenomenon is primarily attributed to the controlled filament formation along unique heterophase grain boundaries. Furthermore, the hybrid nanocomposite synaptic device achieved an image recognition accuracy of 94.3% in Artificial Neural Network (ANN) simulations by using the Modified National Institute of Standards and Technology (MNIST) dataset. These results imply that the device's performance has promising implications for facilitating efficient neuromorphic architectures in the future.}, archive = {J_ADVS}, author = {Faisal Ghafoor and Honggyun Kim and Bilal Ghafoor and Zaheer Ahmed and Muhammad Farooq Khan and Muhammad Rabeel and Muhammad Faheem Maqsood and Sobia Nasir and Wajid Zulfiqar and Ghulam Dastageer and Myoung-Jae Lee and Deok-kee Kim}, doi = {10.1002/advs.202408133}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2408133}, shortjournal = {Adv. Sci.}, title = {Novel solution-processed Fe2O3/WS2 hybrid nanocomposite dynamic memristor for advanced power efficiency in neuromorphic computing}, volume = {12}, year = {2025}, }
• (2025). AKT1 phosphorylates FDX1 to promote cuproptosis resistance in triple-negative breast cancer. ADVS, 12(17), 2408106. (www)

  @article{ , abstract = {Cuproptosis, a recently defined copper-dependent cell death pathway, remains largely unexplored in tumor therapies, particularly in breast cancer. This study demonstrates that triple-negative breast cancer (TNBC) bears a relatively elevated copper levels and exhibits resistance to cuproptosis. Mechanistically, copper activates the AKT signaling pathway, which inhibits ferredoxin-1 (FDX1), a key regulator of cuproptosis. AKT1-mediated FDX1 phosphorylation not only abrogates FDX1-induced cuproptosis and aerobic respiration but also promotes glycolysis. Consequently, the combination of AKT1 inhibitors and the copper ionophores synergistically alleviate TNBC tumorigenesis both in vitro and in vivo. In summary, the findings reveal a crucial mechanism underlying TNBC resistance to cuproptosis and suggest a potential therapeutic approach for TNBC.}, archive = {J_ADVS}, author = {Zicheng Sun and Huazhen Xu and Guanming Lu and Ciqiu Yang and Xinya Gao and Jing Zhang and Xin Liu and Yongcheng Chen and Kun Wang and Jianping Guo and Jie Li}, doi = {10.1002/advs.202408106}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2408106}, shortjournal = {Adv. Sci.}, title = {AKT1 phosphorylates FDX1 to promote cuproptosis resistance in triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). Chromatin organization governs transcriptional response and plasticity of cancer stem cells. ADVS, 12(17), 2407426. (www)

  @article{ , abstract = {Chromatin organization regulates transcription to influence cellular plasticity and cell fate. We explored whether chromatin nanoscale packing domains are involved in stemness and response to chemotherapy. Using an optical spectroscopic nanosensing technology we show that ovarian cancer-derived cancer stem cells (CSCs) display upregulation of nanoscale chromatin packing domains compared to non-CSCs. Cleavage under targets and tagmentation (CUT&Tag) sequencing with antibodies for repressive H3K27me3 and active H3K4me3 and H3K27ac marks mapped chromatin regions associated with differentially expressed genes. More poised genes marked by both H3K4me3 and H3K27me3 were identified in CSCs vs. non-CSCs, supporting increased transcriptional plasticity of CSCs. Pathways related to Wnt signaling and cytokine-cytokine receptor interaction were repressed in non-CSCs, while retinol metabolism and antioxidant response were activated in CSCs. Comparative transcriptomic analyses showed higher intercellular transcriptional heterogeneity at baseline in CSCs. In response to cisplatin, genes with low baseline expression levels underwent the highest upregulation in CSCs, demonstrating transcriptional plasticity under stress. Epigenome targeting drugs downregulated chromatin packing domains and promoted cellular differentiation. A disruptor of telomeric silencing 1-like (Dot1L) inhibitor blocked transcriptional plasticity, reversing stemness. These findings support that CSCs harbor upregulated chromatin packing domains, contributing to transcriptional and cell plasticity that epigenome modifiers can target.}, archive = {J_ADVS}, author = {Yinu Wang and Jane Frederick and Karla Isabel Medina and Elizabeth Thomas Bartom and Luay Matthew Almassalha and Yaqi Zhang and Greta Wodarcyk and Hao Huang and I Chae Ye and Ruyi Gong and Cody Levi Dunton and Alex Duval and Paola Carrillo Gonzalez and Joshua Pritchard and John Carinato and Iuliia Topchu and Junzui Li and Zhe Ji and Mazhar Adli and Vadim Backman and Daniela Matei}, doi = {10.1002/advs.202407426}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2407426}, shortjournal = {Adv. Sci.}, title = {Chromatin organization governs transcriptional response and plasticity of cancer stem cells}, volume = {12}, year = {2025}, }
• (2025). Interpretable multimodal fusion model for bridged histology and genomics survival prediction in pan-cancer. ADVS, 12(17), 2407060. (www)

  @article{ , abstract = {Understanding the prognosis of cancer patients is crucial for enabling precise diagnosis and treatment by clinical practitioners. Multimodal fusion models based on artificial intelligence (AI) offer a comprehensive depiction of the tumor heterogeneity landscape, facilitating more accurate predictions of cancer patient prognosis. However, in the real-world, the lack of complete multimodal data from patients often hinders the practical clinical utility of such models. To address this limitation, an interpretable bridged multimodal fusion model is developed that combines histopathology, genomics, and transcriptomics. This model assists clinical practitioners in achieving more precise prognosis predictions, particularly when patients lack corresponding molecular features. The predictive capabilities of the model are validated across 12 cancer types, achieving optimal performance in both complete and missing modalities. The work highlights the promise of developing a clinically applicable medical multimodal fusion model. This not only aids in reducing the healthcare burden on cancer patients but also provides improved assistance for clinical practitioners in precise diagnosis and treatment.}, archive = {J_ADVS}, author = {Feng Gao and Junxiang Ding and Baowen Gai and Du Cai and Chuling Hu and Feng-Ao Wang and Ruikun He and Junwei Liu and Yixue Li and Xiao-Jian Wu}, doi = {10.1002/advs.202407060}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2407060}, shortjournal = {Adv. Sci.}, title = {Interpretable multimodal fusion model for bridged histology and genomics survival prediction in pan-cancer}, volume = {12}, year = {2025}, }
• (2025). CCL20/CXCL5 drives crosstalk between anaplastic thyroid cancer stem cells and tumor-associated macrophages to promote tumor progression. ADVS, 12(17), 2405399. (www)

  @article{ , abstract = {The dynamic interplay between tumor-associated macrophages (TAMs) and anaplastic thyroid cancer (ATC) shapes the tumor microenvironment and facilitates ATC progression. However, the mechanisms of communication between TAMs and anaplastic thyroid cancer stem cells (ATCSCs) remain largely unelucidated. Integrative analyses of single-cell RNA sequencing, cytokine/chemokine arrays, proteomics, and mRNA expression datasets are performed to reveal crosstalk between TAMs and ATCSCs and signaling pathways in ATCSCs. Subsequently, in vitro experiments are performed to validate the regulatory effects of key cytokines on ATCSC stemness. Last, xenogeneic orthotopic thyroid ATCSCs transplantation models are utilized to corroborate the regulatory effect of cytokines on stemness. CCL20 derived from THP-1-M2 activates the IRAK-1/NF-κB1/2 signaling pathway in ATCSCs, thereby positively regulating stemness characteristics and upregulating CXCL5 secretion. ATCSCs not only exhibit autocrine CXCL5 participation in the regulation of stemness but also demonstrate paracrine CXCL5 activity to recruit THP-1-Mφ and maintain the M2 phenotype. CCL20 and CXCL5 are involved in the crosstalk between TAMs and ATCSCs. The CCL20/CXCL5 axis plays a crucial role in the interaction between TAMs and ATCSCs, establishing a progressive tumor microenvironment.}, archive = {J_ADVS}, author = {Qi Liu and Yan Wang and Mingyuan Song and Jiapeng Huang and Jinyuan Shi and Wei Sun and Xiaoyu Ji and Yuang Chang and Bing Ma and Ping Zhang and Yuanyuan Yan and Hao Zhang}, doi = {10.1002/advs.202405399}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2405399}, shortjournal = {Adv. Sci.}, title = {CCL20/CXCL5 drives crosstalk between anaplastic thyroid cancer stem cells and tumor-associated macrophages to promote tumor progression}, volume = {12}, year = {2025}, }
• (2025). Metabolic-immune suppression mediated by the SIRT1-CX3CL1 axis induces functional enhancement of regulatory t cells in colorectal carcinoma. ADVS, 12(17), 2404734. (www)

  @article{ , abstract = {Metabolic reprogramming of tumor cells dynamically reshapes the distribution of nutrients and signals in the tumor microenvironment (TME), affecting intercellular interactions and resulting in metabolic immune suppression. Increased glucose uptake and metabolism are characteristic of many tumors. Meanwhile, the progression of colorectal carcinoma (CRC) relies on lipid metabolism. Therefore, investigating the role of glucolipid metabolic reprogramming on tumor immunity contributes to identifying new targets for immune suppression intervention in CRC. Our previous work demonstrated that SIRT1 is the hub gene involved in glucolipid metabolic conversion in CRC. Here, it is found that upregulated SIRT1 in CRC cells increases Treg functionality by promoting the secretion of CX3CL1. The CX3CL1-CX3CR1 signaling activated transcription factors SATB1 and BTG2, promoting the differentiation of TCF7 + Treg cells into functionally enhanced TNFRSF9 + Treg cells. Multiplex immunofluorescence (mIHC) analysis of a CRC tissue microarray confirmed the promoting effect of CX3CL1 on Treg infiltration. Additionally, the therapeutic efficacy of CX3CR1 inhibitor monotherapy and combination therapy is validated with the PD-1 antibody in the humanized subcutaneous CRC mouse model. This study elucidates a potential mechanism that metabolic reprogramming of cancer cells collaborates with subsequent immunosuppression to promote CRC progression.}, archive = {J_ADVS}, author = {Ruiyang Zi and Xiang Zhao and Limei Liu and Yijie Wang and Rui Zhang and Zhiheng Bian and Haoran Jiang and Taorui Liu and Yixin Sun and Han Peng and Xuesong Wang and Fanghao Lu and Chao Zhang and Fan Zhang and Qing Qin and Houjie Liang and Jianjun Li and Zhihao Wei and Yan Dong}, doi = {10.1002/advs.202404734}, journal = {Advanced Science}, month = {5}, number = {17}, pages = {2404734}, shortjournal = {Adv. Sci.}, title = {Metabolic-immune suppression mediated by the SIRT1-CX3CL1 axis induces functional enhancement of regulatory t cells in colorectal carcinoma}, volume = {12}, year = {2025}, }
• (2025). Tumor microenvironment on-A-chip and single-cell analysis reveal synergistic Stromal–Immune crosstalk on breast cancer progression (Adv. sci. 16/2025). ADVS, 12(16), 2570119. (www)

  @article{ , archive = {J_ADVS}, author = {Kalpana Ravi and Yining Zhang and Lydia Sakala and Twinkle Jina Minette Manoharan and Barbara Pockaj and Joshua LaBaer and Jin G. Park and Mehdi Nikkhah}, doi = {10.1002/advs.202570119}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2570119}, shortjournal = {Adv. Sci.}, title = {Tumor microenvironment on-A-chip and single-cell analysis reveal synergistic Stromal–Immune crosstalk on breast cancer progression (Adv. sci. 16/2025)}, volume = {12}, year = {2025}, }
• (2025). Roles of kdm6a and kdm6b in regulation of mammalian neural regeneration (Adv. sci. 16/2025). ADVS, 12(16), 2570118. (www)

  @article{ , archive = {J_ADVS}, author = {Shu-Guang Yang and Chang-Ping Li and Xue-Wei Wang and Tao Huang and Cheng Qian and Qiao Li and Ling-Rui Zhao and Si-Yu Zhou and Chen-Yun Ding and Rui Nie and Saijilafu and Yu-Cai Hong and Chang-Mei Liu and Feng-Quan Zhou}, doi = {10.1002/advs.202570118}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2570118}, shortjournal = {Adv. Sci.}, title = {Roles of kdm6a and kdm6b in regulation of mammalian neural regeneration (Adv. sci. 16/2025)}, volume = {12}, year = {2025}, }
• (2025). Subsurface oxygen vacancy mediated surface reconstruction and depolarization of ferroelectric BaTiO3 (001) surface (Adv. sci. 16/2025). ADVS, 12(16), 2570117. (www)

  @article{ , archive = {J_ADVS}, author = {Jeehun Jeong and Jaejin Hwang and Yaolong Xing and Zhipeng Wang and Jaekwang Lee and Sang Ho Oh}, doi = {10.1002/advs.202570117}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2570117}, shortjournal = {Adv. Sci.}, title = {Subsurface oxygen vacancy mediated surface reconstruction and depolarization of ferroelectric BaTiO3 (001) surface (Adv. sci. 16/2025)}, volume = {12}, year = {2025}, }
• (2025). High-conductivity, self-healing, and adhesive ionic hydrogels for health monitoring and human-machine interactions under extreme cold conditions (Adv. sci. 16/2025). ADVS, 12(16), 2570116. (www)

  @article{ , archive = {J_ADVS}, author = {Fei Han and Shumeng Chen and Fei Wang and Mei Liu and Jiahui Li and Hao Liu and Yanshen Yang and Haoqing Zhang and Dong Liu and Rongyan He and Wentao Cao and Xiaochuan Qin and Feng Xu}, doi = {10.1002/advs.202570116}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2570116}, shortjournal = {Adv. Sci.}, title = {High-conductivity, self-healing, and adhesive ionic hydrogels for health monitoring and human-machine interactions under extreme cold conditions (Adv. sci. 16/2025)}, volume = {12}, year = {2025}, }
• (2025). MaTableGPT: GPT-based table data extractor from materials science literature (Adv. sci. 16/2025). ADVS, 12(16), 2570114. (www)

  @article{ , archive = {J_ADVS}, author = {Gyeong Hoon Yi and Jiwoo Choi and Hyeongyun Song and Olivia Miano and Jaewoong Choi and Kihoon Bang and Byungju Lee and Seok Su Sohn and David Buttler and Anna Hiszpanski and Sang Soo Han and Donghun Kim}, doi = {10.1002/advs.202570114}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2570114}, shortjournal = {Adv. Sci.}, title = {MaTableGPT: GPT-based table data extractor from materials science literature (Adv. sci. 16/2025)}, volume = {12}, year = {2025}, }
• (2025). Programmed fabrication of vesicle-based prototissue fibers with modular functionalities (Adv. sci. 16/2025). ADVS, 12(16), 2570113. (www)

  @article{ , archive = {J_ADVS}, author = {Tomoya Kojima and Kouichi Asakura and Pierangelo Gobbo and Taisuke Banno}, doi = {10.1002/advs.202570113}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2570113}, shortjournal = {Adv. Sci.}, title = {Programmed fabrication of vesicle-based prototissue fibers with modular functionalities (Adv. sci. 16/2025)}, volume = {12}, year = {2025}, }
• (2025). Machine learning-enabled drug-induced toxicity prediction (Adv. sci. 16/2025). ADVS, 12(16), 2570112. (www)

  @article{ , archive = {J_ADVS}, author = {Changsen Bai and Lianlian Wu and Ruijiang Li and Yang Cao and Song He and Xiaochen Bo}, doi = {10.1002/advs.202570112}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2570112}, shortjournal = {Adv. Sci.}, title = {Machine learning-enabled drug-induced toxicity prediction (Adv. sci. 16/2025)}, volume = {12}, year = {2025}, }
• (2025). ROS-responsive microneedle patches enable peri-lacrimal gland therapeutic administration for long-acting therapy of sjögren's syndrome-related dry eye (Adv. sci. 16/2025). ADVS, 12(16), 2570111. (www)

  @article{ , archive = {J_ADVS}, author = {Jingqing Mu and Xiangyu Ding and Yapeng Song and Baoyue Mi and Xiaolong Fang and Baihua Chen and Bin Yao and Xuguang Sun and Xiaoyong Yuan and Shutao Guo and Xia Hua}, doi = {10.1002/advs.202570111}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2570111}, shortjournal = {Adv. Sci.}, title = {ROS-responsive microneedle patches enable peri-lacrimal gland therapeutic administration for long-acting therapy of sjögren's syndrome-related dry eye (Adv. sci. 16/2025)}, volume = {12}, year = {2025}, }
• (2025). Functional divergence of plant-derived thaumatin-like protein genes in two closely related whitefly species. ADVS, 12(16), 2502193. (www)

  @article{ , abstract = {The recent discovery that various insects have acquired functional genes through horizontal gene transfer (HGT) has prompted numerous studies into this puzzling and fascinating phenomenon. So far, horizontally transferred genes are found to be functionally conserved and largely retained their ancestral functions. It evidently has not yet been considered that horizontally transferred genes may evolve and can contribute to divergence between species. Here, it is first showed that the genomes of the two widespread and agriculturally important whiteflies Trialeurodes vaporariorum and Bemisia tabaci both contain a plant-derived thaumatin-like protein ( TLP ) gene, but with highly distinct functions in these closely related pests. In T. vaporariorum , TLP has maintained a function similar to that of the plant donor, acting as an antimicrobial protein to resist fungal infection; but in sharp contrast, in B. tabaci , TLP has evolved into an effector that suppresses plant defense responses. These findings reveal an as-yet undescribed scenario of cross-species functional differentiation of horizontally transferred genes and suggest that the HGT-mediated evolutionary novelty can contribute to ecotypic divergence and even speciation.}, archive = {J_ADVS}, author = {Yuan Hu and Cheng Gong and Zezhong Yang and Haolin Han and Tian Tian and Xin Yang and Wen Xie and Shaoli Wang and Qingjun Wu and Xuguo Zhou and Ted C. J. Turlings and Zhaojiang Guo and Youjun Zhang}, doi = {10.1002/advs.202502193}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2502193}, shortjournal = {Adv. Sci.}, title = {Functional divergence of plant-derived thaumatin-like protein genes in two closely related whitefly species}, volume = {12}, year = {2025}, }
• (2025). Ultra–Efficient and selective gold separation via Second–Sphere coordination of aurous dihalide using a nonporous amorphous superadsorbent. ADVS, 12(16), 2501397. (www)

  @article{ , abstract = {The escalating demand for gold, coupled with dwindling terrestrial reserves, underscores the urgent need for innovative separation strategies, including e–waste recycling and seawater extraction. However, the development of ultra–efficient, highly selective adsorbents capable of recovering trace amounts of gold from complex aquatic matrices remains a formidable challenge. Herein, a covalent organic superphane cage is reported as a nonporous amorphous superadsorbent (NAS) for selective and efficient gold recovery via intermolecular second–sphere coordination of AuBr₂⁻ (or AuCl₂⁻) ions, subsequently converted to metallic gold through disproportionation. NAS demonstrates outstanding performance, including an exceptional gold uptake capacity of 2750 mg g⁻¹, ultrafast adsorption kinetics (40 s), broad pH tolerance (1–11, up to 6 M acids), and remarkable gold uptake even in 36 wt.% HCl solution (821 mg g⁻¹). NAS achieves over 99% selective gold recovery, even amidst excess competing ions, retaining efficacy across 30 regeneration cycles. Its versatile and scalable design enables applications in gold separation from gold-bearing e–waste, catalytic residues, gold ores, and seawater. A large–scale trial recovered 23.8 Karat gold from printed circuit board leachates, positioning NAS as a sustainable and eco–friendly solution for industrial and environmental gold recovery.}, archive = {J_ADVS}, author = {Wei Zhou and Xiao Cai and Yiyao Xu and Min Zhou and Jialian Li and Qiang Liu and Qing He}, doi = {10.1002/advs.202501397}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2501397}, shortjournal = {Adv. Sci.}, title = {Ultra–Efficient and selective gold separation via Second–Sphere coordination of aurous dihalide using a nonporous amorphous superadsorbent}, volume = {12}, year = {2025}, }
• (2025). Bioengineering platelets presenting PD-l1, galectin-9 and BTLA to ameliorate type 1 diabetes. ADVS, 12(16), 2501139. (www)

  @article{ , abstract = {Autoimmune destruction of pancreatic β -cells leads to impaired insulin production and onset of type 1 diabetes (T1D). Hence, immunomodulation of pancreas-infiltrated immune cells especially the β -cells autoreactive-T cells is a promising way to hinder and reverse the progress of T1D. Herein, megakaryocytes are primed with interferon- γ (IFN- γ ) to produce platelets presenting high levels of immunosuppressive checkpoint ligands including programmed death-ligand 1 (PD-L1), Programmed Death-Ligand 2 (PD-L2), the B and T lymphocyte attenuator (BTLA) and Galectin-9 (Gal-9), termed as IFN- γ platelets. The IFN- γ platelets bound and interacted with T cells through immune checkpoint ligands and receptors, which efficaciously induced T cell exhaustion and apoptosis in vitro. Virtually, NOD diabetes mice received IFN- γ platelets treatments prominently preserved β -cell integrity and insulin production, ultimately hindering the progress to hyperglycemia. Intriguingly, both the amount and activity of the pancreas infiltrate-T cells intensively reduced, whereas the magnitude of regulatory T cells (Tregs) remarkably increased, which is attributed to IFN- γ platelets treatments. Moreover, IFN- γ platelets treatment instigated macrophage polarization toward an anti-inflammatory M2 phenotype that may stimulate pancreatic angiogenesis, and promote β -cell proliferation, consequently ameliorating the new-onset T1D.}, archive = {J_ADVS}, author = {Yumeng Ma and Fanqiang Meng and Zhongda Lin and Yanjun Chen and Tianyu Lan and Zhaoxin Yang and Rui Diao and Xiaozhou Zhang and Qi Chen and Chi Zhang and Yishi Tian and Chanjuan Li and Wenli Fang and Xin Liang and Xudong Zhang}, doi = {10.1002/advs.202501139}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2501139}, shortjournal = {Adv. Sci.}, title = {Bioengineering platelets presenting PD-l1, galectin-9 and BTLA to ameliorate type 1 diabetes}, volume = {12}, year = {2025}, }
• (2025). Functional materials targeted regulation of gasdermins: From fundamentals to functionalities and applications. ADVS, 12(16), 2500873. (www)

  @article{ , abstract = {Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti-inflammatory therapy. However, pyroptosis acts as a double-edged sword, making it important to optimize the design strategies of functional materials to appropriately activate pyroptosis for effective disease treatment. This paper summarizes and discusses the structure, pore formation, and molecular mechanisms of “executor” Gasdermins, as well as the events preceding and following these processes. Subsequently, the focus is on reviewing functional materials that directly regulate Gasdermin pore formation to target pyroptosis and those that indirectly regulate the events before and after Gasdermin pore formation to control pyroptosis activity. Finally, the advantages, disadvantages, and future prospects of designing such functional materials are provided, aiming to facilitate the precise design, pharmacological investigation, and clinical translation of pyroptosis-related functional materials.}, archive = {J_ADVS}, author = {Luyao Tian and Shuo Piao and Xia Li and Lanping Guo and Luqi Huang and Wenyuan Gao}, doi = {10.1002/advs.202500873}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2500873}, shortjournal = {Adv. Sci.}, title = {Functional materials targeted regulation of gasdermins: From fundamentals to functionalities and applications}, volume = {12}, year = {2025}, }
• (2025). Agile free-form signal filtering and routing with a chaotic-cavity-backed non-local programmable metasurface. ADVS, 12(16), 2500796. (www)

  @article{ , abstract = {Filter synthesis is an inverse problem that is traditionally approached rationally by engineering the coupling between selected pairs of lumped resonators. The implicit restriction to spatially disjoint resonators strongly limits the design space, making it challenging to build extremely tunable filters. Here, agile free-form signal filtering and routing are demonstrated with an alternative purely-optimization-based approach leveraging a multi-parameter programmable system with many spatially overlapping modes. The approach is largely insensitive to system details other than the programmable system configuration. In the fabricated prototype, all ports and tunable meta-elements are strongly coupled via a quasi-2D chaotic cavity such that the meta-elements’ configuration efficiently controls the transfer function between the ports. The all-metallic device enables low-loss and ultra-wideband (UWB) tunability (7.5–13.5 GHz) and guarantees signal-strength-independent linearity. First, theoretical predictions about reflectionless and transmissionless scattering modes (including transmissionless exceptional points) are experimentally confirmed. Second, these transfer function zeros are imposed at desired frequencies within an UWB range. Third, low-loss reflectionless programmable signal routing is achieved. Fourth, the trade-off between routing fidelity and bandwidth is investigated, achieving 20 dB discrimination over 10 MHz bandwidth. Fifth, UWB-tunable multi-band filtering is demonstrated that rejects (< –24 dB) or passes (≥ –1 dB) signals in specified bands whose centers, widths and number are reprogrammable.}, archive = {J_ADVS}, author = {Fabian T. Faul and Laurent Cronier and Ali Alhulaymi and A. Douglas Stone and Philipp del Hougne}, doi = {10.1002/advs.202500796}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2500796}, shortjournal = {Adv. Sci.}, title = {Agile free-form signal filtering and routing with a chaotic-cavity-backed non-local programmable metasurface}, volume = {12}, year = {2025}, }
• (2025). Engineering extracellular vesicles derived from 3D cultivation of BMSCs enriched with HGF ameliorate sepsis-induced lung epithelial barrier damage. ADVS, 12(16), 2500637. (www)

  @article{ , abstract = {Sepsis is a critical condition with high mortality, often leading to acute lung injury (ALI) due to uncontrolled inflammatory responses and alveolar epithelial damage. Extracellular vesicles (EVs), particularly mesenchymal stem cell-derived EVs, have shown therapeutic potential in sepsis-related organ dysfunction by transferring RNAs and proteins. However, their clinical use is limited by low efficacy and yield. To address this, 3D-cultured MSCs (3D-MSCs) are generated using MicroTissues 3D Petri Dish. These 3D-MSCs demonstrate improved protection and proliferation of MLE-12 cells in vitro. Mechanistic studies are conducted to explore the enhanced protective effects of 3D-MSCs derived EVs (3D-EVs) in a septic-ALI model. Proteomic and molecular analyses of 3D-EVs revealed that they are enriched in hepatocyte growth factor (HGF). HGF helps maintain the barrier function of damaged alveolar epithelium through the PI3K-AKT signaling pathway. Overall, 3D-EVs effectively ameliorate sepsis-induced ALI and enhance prognosis by enriching and delivering HGF, suggesting that their application represents a promising treatment strategy for septic ALI.}, archive = {J_ADVS}, author = {Yong Chen and Feihong Lin and Tong Zhang and Zhuoran Xiao and Yuanli Chen and Dongsheng Hua and Yu Wang and Juan Wei and Tian Jin and Xin Lv}, doi = {10.1002/advs.202500637}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2500637}, shortjournal = {Adv. Sci.}, title = {Engineering extracellular vesicles derived from 3D cultivation of BMSCs enriched with HGF ameliorate sepsis-induced lung epithelial barrier damage}, volume = {12}, year = {2025}, }
• (2025). Excellent dynamic non-wetting performance induced by asymmetric structure at low temperatures: Retraction actuation and nucleation inhibition. ADVS, 12(16), 2500590. (www)

  @article{ , abstract = {Asymmetric structures have exhibited significant advantages in regulating wetting behavior. Nevertheless, the influence of this unique structural feature on anti-icing performance remains to be further explored. In this work, static/dynamic anti-icing performance is investigated on the asymmetric superhydrophobic structures fabricated by micro-milling combined with electrodeposition. Notably, although the reduction of the degree of asymmetry increases the droplet adhesion force by augmenting the solid-liquid interface, asymmetric structures can still enable the droplet to bounce off the surface through the horizontal Laplace force generated by the contact angle difference between the two sides of the droplet. On this basis, a dynamic behavior criterion for the droplet to detach from the surface is established at low temperatures. Molecular dynamics simulation indicates that the asymmetric structure can reduce the icing probability on the precursor film by inhibiting the nucleation and growth process of water molecules, decreasing the liquid-ice interface, and reducing the adhesion under low temperatures. Generally, specific asymmetric structures with nucleation inhibition characteristics can reduce droplet adhesion and increase the driving force during the droplet retraction stage by enhancing the horizontal Laplace force, effectively improving the dynamic non-wetting performance of the surface at even −40 °C.}, archive = {J_ADVS}, author = {Jiawei Jiang and Yizhou Shen and Yangjiangshan Xu and Zhen Wang and Senyun Liu and Yanyan Lin and Jie Tao and Zhong Chen}, doi = {10.1002/advs.202500590}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2500590}, shortjournal = {Adv. Sci.}, title = {Excellent dynamic non-wetting performance induced by asymmetric structure at low temperatures: Retraction actuation and nucleation inhibition}, volume = {12}, year = {2025}, }
• (2025). π–π conjugated bonds Stacking/Scattering for switchable lubrication in supramolecular hydrogel. ADVS, 12(16), 2500447. (www)

  @article{ , abstract = {Existing polymer materials often lack the ability to dynamically adjust lubrication in response to external stimuli. This gap in adaptable lubrication technology limits their application in advanced systems such as intelligent motion devices and soft robotics. To address this challenge, a dual-responsive lubricating hydrogel is introduced designed with a thermal and shear-responsive supramolecular network integrated into a stable polymer framework. The hydrogel exhibits a partial gel-sol transition under thermal or shear stress, mimicking the mucus secretion behavior of hagfish. As a result, the hydrogel′s surface secretes a liquid supramolecular layer that significantly alters its coefficient of friction (COF), achieving up to a 20-fold reduction in friction due to the reversible supramolecular transition. This hydrogel demonstrates significant potential as an intelligent lubrication material capable of dynamically responding to varying stimuli, paving the way for more adaptive and efficient lubrication technologies.}, archive = {J_ADVS}, author = {Shuhang Deng and Shijia He and Guilong Yan and Li Wang and Zhenyu Li and Jingyu Chen and Jingjuan Lai and Dong Li and Dong Xiang and Chunxia Zhao and Hui Li and Xuezhong Zhang and Han Li and Xungai Wang and Yuanpeng Wu}, doi = {10.1002/advs.202500447}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2500447}, shortjournal = {Adv. Sci.}, title = {π–π conjugated bonds Stacking/Scattering for switchable lubrication in supramolecular hydrogel}, volume = {12}, year = {2025}, }
• (2025). NIR-II fluorescent protein created by in situ albumin-tagging for sensitive and specific imaging of blood-brain barrier disruption. ADVS, 12(16), 2500443. (www)

  @article{ , abstract = {Imaging albumin in vivo is a reliable strategy to visualize blood-brain barrier (BBB) disruption by detecting the dye-labeled albumin leaking into brain parenchyma. Although Evans Blue (EB) and indocyanine green (ICG) dyes have been applied to assess BBB impairment, their naked-eye observation or near-infrared-I (NIR-I) imaging window limit the imaging sensitivity and contrast for this promising “albumin-based” strategy. Herein, an albumin-specific tagged near-infrared-II (NIR-II) probe is engineered as a chromophore to construct fluorescent proteins (FPs) in situ for assessing BBB disruption in stroke. The optimized chromophore, C7-1080, can covalently bind to albumin through nucleophilic substitution, forming FPs without adjuvant. Notably, the albumin effectively acts as a brightness enhancer and stability regulator for chromophores through the tight clamping effect. Theoretical simulation, proteomics, and protein mutation techniques are employed to investigate the binding behavior between albumin and chromophore. The in situ NIR-II FPs construction strategy facilitates high-precision dual-channel imaging of BBB disruption and cerebral vessels during ischemic stroke when combined with the IR-808Ac probe. Overall, the in situ albumin-specific tag holds promise for diagnosing and monitoring strokes, presenting a tool for investigating the progression and therapeutic responses of related diseases.}, archive = {J_ADVS}, author = {Jiajun Xu and Yijing Du and Ningning Zhu and Jia Li and Yuewei Zhang and Ding Zhou and Shoujun Zhu}, doi = {10.1002/advs.202500443}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2500443}, shortjournal = {Adv. Sci.}, title = {NIR-II fluorescent protein created by in situ albumin-tagging for sensitive and specific imaging of blood-brain barrier disruption}, volume = {12}, year = {2025}, }
• (2025). Sulfur bridge geometry boosts selective FeIV═O generation for efficient fenton-like reactions. ADVS, 12(16), 2500313. (www)

  @article{ , abstract = {High-valent iron–oxo species (Fe IV ═O) is a fascinating enzymatic agent with excellent anti-interference abilities in various oxidation processes. However, selective and high-yield production of Fe IV ═O remains challenging. Herein, Fe diatomic pairs are rationally fabricated with an assisted S bridge to tune their neighbor distances and increase their loading to 11.8 wt.%. This geometry regulated the d -band center of Fe atoms, favoring their bonding with the terminal and hydroxyl O sites of peroxymonosulfate (PMS) via heterolytic cleavage of O─O, improving the PMS utilization (70%), and selective generation of Fe IV ═O (>90%) at a high yield (63% of PMS) offers competitive performance against state-of-the-art catalysts. These continuous reactions in a fabricated device and technol-economic assessment further verified the catalyst with impressive long-term activity and scale-up potential for sustainable water treatment. Altogether, this heteroatom-bridge strategy of diatomic pairs constitutes a promising platform for selective and efficient synthesis of high-valent metal–oxo species.}, archive = {J_ADVS}, author = {Xunheng Jiang and Zhongyuan Guo and Jiang Xu and Zhiyu Pan and Chen Miao and Yue Chen and Hao Li and Hiroshi Oji and Yitao Cui and Graeme Henkelman and Xinhua Xu and Lizhong Zhu and Daohui Lin}, doi = {10.1002/advs.202500313}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2500313}, shortjournal = {Adv. Sci.}, title = {Sulfur bridge geometry boosts selective FeIV═O generation for efficient fenton-like reactions}, volume = {12}, year = {2025}, }
• (2025). Verifying the unique charge migration pathway in polymeric homojunctions for artificial photosynthesis of hydrogen peroxide. ADVS, 12(16), 2500218. (www)

  @article{ , abstract = {Artificial photosynthesis for producing high-value hydrogen peroxide (H 2 O 2 ) using carbon nitride-based systems holds immense potential. However, understanding the charge transfer dynamics in homojunction photocatalysts remains a significant challenge owing to the limitations of current characterization techniques. Here, a polymeric C 3 N 5 /C 3 N 4 homojunction (CNHJ) is employed as a model system to probe interfacial electron transfer. Bimetallic cocatalysts serve as sensitive probes, enabling in situ tracking of the S-scheme electron transfer between C 3 N 5 and C 3 N 4 via X-ray photoelectron spectroscopy. Leveraging the unique advantages of this S-scheme, the CNHJ demonstrates substantially enhanced performance in the two-electron oxygen reduction reaction, achieving an impressive H 2 O 2 production rate of 8.78 mmol g −1 h −1 under visible light irradiation. Furthermore, the system demonstrates robust performance in continuous-flow setups, under natural sunlight, and in photocatalytic disinfection tests, highlighting its practical potential. This approach offers new insights into dynamic electron transfer mechanisms and paves the way for advancing artificial photosynthesis technologies.}, archive = {J_ADVS}, author = {Qiang Cheng and Jingping Li and Yuxin Huang and Xiufan Liu and Biao Zhou and Qiao Xiong and Kai Wang}, doi = {10.1002/advs.202500218}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2500218}, shortjournal = {Adv. Sci.}, title = {Verifying the unique charge migration pathway in polymeric homojunctions for artificial photosynthesis of hydrogen peroxide}, volume = {12}, year = {2025}, }
• (2025). CaMKK2 regulates macrophage polarization induced by matrix stiffness: Implications for shaping the immune response in stiffened tissues. ADVS, 12(16), 2417778. (www)

  @article{ , abstract = {Macrophages are essential for immune responses and maintaining tissue homeostasis, exhibiting a wide range of phenotypes depending on their microenvironment. The extracellular matrix (ECM) is a vital component that provides structural support and organization to tissues, with matrix stiffness acting as a key regulator of macrophage behavior. Using physiologically relevant 3D stiffening hydrogel models, it is found that increased matrix stiffness alone promoted macrophage polarization toward a pro-regenerative phenotype, mimicking the effect of interleukin-4(IL-4) in softer matrices. Blocking Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) selectively inhibited stiffness-induced macrophage polarization without affecting IL-4-driven pro-regenerative pathways. In functional studies, CaMKK2 deletion prevented M2-like/pro-tumoral polarization caused by matrix stiffening, which in turn hindered tumor growth. In a murine wound healing model, loss of CaMKK2 impaired matrix stiffness-mediated macrophage accumulation, ultimately disrupting vascularization. These findings highlight the critical role of CaMKK2 in the macrophage mechanosensitive fate determination and gene expression program, positioning this kinase as a promising therapeutic target to selectively modulate macrophage responses in pathologically stiff tissues.}, archive = {J_ADVS}, author = {Ya Guan and Min Zhang and Jiyeon Song and Marcos Negrete and Tyler Adcock and Reeva Kandel and Luigi Racioppi and Sharon Gerecht}, doi = {10.1002/advs.202417778}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2417778}, shortjournal = {Adv. Sci.}, title = {CaMKK2 regulates macrophage polarization induced by matrix stiffness: Implications for shaping the immune response in stiffened tissues}, volume = {12}, year = {2025}, }
• (2025). Solvent-free supramolecular polymerization for feather-like nanostructured chiral fluorescent polyurethanes with multimodal chiroptical stimuli responsiveness. ADVS, 12(16), 2417572. (www)

  @article{ , abstract = {Chiral supramolecular polymers with stimuli-responsive circularly polarized luminescence (CPL) are highly desirable for smart flexible optoelectronic devices, but remain rarely reported. Here, a simple solvent-free supramolecular polymerization for preparing chiral polyurethanes is presented by in situ induced self-assembly strategy, using cellulose nanocrystals (CNCs)-based isocyanate prepolymers and macromolecular polyols as precursors, achieving precise control over polymer chain assembly with spot-like arrangement. More importantly, by further incorporating a π-conjugated luminescent dihydroxynaphthalene molecule, CPL-active flexible polyurethane films with feather-like nanostructures are constructed, which promote the ordered arrangement of CNCs-based isocyanate segments due to the increased spatial resistance. The π─H bond network between CNCs and urethane-linked benzene rings drives the self-assembly, enabling higher-level chiral amplification and enhanced fluorescence. Interestingly, the prepared chiral fluorescent polyurethanes display multimodal chiroptical stimuli responsiveness under various stimuli, such as temperature, solvent polarity, pH, and polarized light, due to the sensitivity of the π─H bond network. This work offers new insights into designing solvent-free chiral supramolecular polymers with significant chiroptical potentials.}, archive = {J_ADVS}, author = {Huimin Duan and Shuli Li and Xinlei Wu and Jianping Deng and Jiawei Li and Dongming Qi and Biao Zhao}, doi = {10.1002/advs.202417572}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2417572}, shortjournal = {Adv. Sci.}, title = {Solvent-free supramolecular polymerization for feather-like nanostructured chiral fluorescent polyurethanes with multimodal chiroptical stimuli responsiveness}, volume = {12}, year = {2025}, }
• (2025). Morphology effect of puffball spores on hemostasis: A promising solution for hemostatic challenges. ADVS, 12(16), 2417566. (www)

  @article{ , abstract = {Hemostatic materials play a crucial role in wound healing by promoting blood concentration or releasing procoagulant factors. While hydrophilic hemostatic materials are effective, they may cause excessive blood loss and difficulty removing from the wound. Conversely, hydrophobic hemostatic materials avoid these issues but may hinder blood concentration and the release of procoagulant factors due to their water-repellent nature. This study investigates the hemostatic properties and underlying mechanism of puffball ( Bovistella sp.) spores, a traditional hemostatic material. The unique hollow ball-rod morphology and strong water affinity of puffball spores enable efficient water removal, leading to improved blood clotting without the drawbacks typically associated with hydrophilic hemostatic materials. Further analysis reveals that the nano-protrusions on the spore surface create a textured hydrophobic surface due to the pinning effect, which prevents adhesion to the wound after clotting. Overall, puffball spores exhibit hemostatic efficacy comparable to the commercial agent QuikClot, with enhanced safety and reduced side effects. Their characteristic morphology, physicochemical properties, and chemical compositions offer inspiration for advancing hemostatic materials and addressing current challenges in wound healing. Additionally, this work provides new perspectives for insight into the pharmacological substance basis of traditional medicine, expanding beyond the conventional component-focused mentality to a material-based insight.}, archive = {J_ADVS}, author = {Xuechang Pei and Yue Feng and Yanru Wu and Jie Zhang and Jianlan Li and Shutai Jiang and Huijun Huang and Ping Qin and Guoqing Li and Xinrui Guo and Mingxian Liu and Chuanxi Wang and Hao Gao}, doi = {10.1002/advs.202417566}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2417566}, shortjournal = {Adv. Sci.}, title = {Morphology effect of puffball spores on hemostasis: A promising solution for hemostatic challenges}, volume = {12}, year = {2025}, }
• (2025). Endothelial PD-1 regulates vascular homeostasis and oligodendrogenesis during brain development. ADVS, 12(16), 2417410. (www)

  @article{ , abstract = {Appropriate vascular and neural development is essential for central nervous system (CNS). Although programmed cell death receptor 1 (PD-1) mediates neurogenesis, its role in cerebrovascular development remains poorly understood. Here, a correlation between cerebral vessels and oligodendrocyte precursor cells (OPCs) is revealed during brain development. The ablation of endothelial PD-1 triggers cortical hypervascularization through excessive angiogenic sprouting, concomitantly driving OPC differentiation. These alterations disrupt blood brain barrier (BBB) maturation, induce dysmyelination, and ultimately result in abnormal behavior in mice. Mechanistically, the loss of endothelial PD-1 suppresses the activity of the Wnt/β-catenin signaling pathway, thereby disrupting normal angiogenesis. Concurrently, it activates the MEK1/2-ERK1/2-GLI1 pathway, leading to increased GREMLIN1 (GREM1) expression. Elevated GREM1 secretion inhibits the BMP/SMAD1/5/SMAD4 signaling cascade in OPCs, which inhibits oligodendrogenesis and myelination. These findings indicate the importance of endothelial cell-intrinsic PD-1 in regulating the oligovascular niche, and suggest potential therapeutic implications for neurological disorders associated with disrupted vascular development.}, archive = {J_ADVS}, author = {Tingting He and Mengtian Zhang and Jie Qin and Yanyan Wang and Sihan Li and Chaoyi Du and Jianwei Jiao and Fen Ji}, doi = {10.1002/advs.202417410}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2417410}, shortjournal = {Adv. Sci.}, title = {Endothelial PD-1 regulates vascular homeostasis and oligodendrogenesis during brain development}, volume = {12}, year = {2025}, }
• (2025). Lipid droplets metabolism mediated by ANXA7-PPARγ signaling axis regulates spinal cord injury repair in mice. ADVS, 12(16), 2417326. (www)

  @article{ , abstract = {Spinal cord injury is characterized by high incidence and high disability, and the specific targets and drugs have not yet been explored. Lipid droplet is a type of organelles that regulates lipid metabolism and oxidative stress. And the regulatory mechanisms of lipid droplets on spinal cord injury remain unclear. Herein, it is found that GTPase activation of Annexin A7 (ANXA7) promotes the up-regulation of genes related to lipid droplet formation. ANXA7 can interact with peroxisome proliferator-activated receptor gamma (PPARγ) to enhance the stability of PPARγ, and promote lipid droplet formation and interaction with mitochondria through promoting Perilipin 5 expression. Then, oxidative stress and lipid peroxidation are inhibited due to the promotion of nuclear factor erythroid 2-related factor 2 (NRF2) nuclear translocation and expression of glutathione peroxidase 4 (GPX4). ANXA7 activation promotes lipid droplet formation and mitochondria-lipid droplet interaction by enhancing nuclear translocation of PPARγ, which contributes to inhibiting lipid peroxidation and neuron damage. Furthermore, activation of PPARγ can promote neural function recovery and spinal cord repair in mice. The focus of this study is to investigate the effects of lipid droplets regulated by ANXA7/PPARγ, providing new targets and strategies for spinal cord injury.}, archive = {J_ADVS}, author = {Lu Chen and Haoran Liu and Linlin Jiang and Zihang Wang and Yong Chang and Na Li and Shiqing Feng}, doi = {10.1002/advs.202417326}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2417326}, shortjournal = {Adv. Sci.}, title = {Lipid droplets metabolism mediated by ANXA7-PPARγ signaling axis regulates spinal cord injury repair in mice}, volume = {12}, year = {2025}, }
• (2025). Natural enzyme-loaded polymeric stealth coating-armed engineered probiotics by disrupting tumor lactate homeostasis to synergistic metabolism-immuno-enzyme dynamic therapy. ADVS, 12(16), 2417172. (www)

  @article{ , abstract = {Reducing L-lactate levels in tumors is crucial for alleviating immunosuppression and enhancing treatment efficacy. Recently, bacteria have great potential in improving lactate levels in the tumor microenvironment due to their physiological properties, tumor tropism, and immunogenicity. However, developing bacterial-based lactate regulation platforms is still facing great challenges due to bacterial modification impacts on activity, macrophage phagocytosis, and complex tumor microenvironment. Herein, an engineered Lactobacillus acidophilus (LH@LA) is developed, armed with a polymeric stealth coating that co-loads lactate oxidase (LOx) and horseradish peroxidase (HRP). This coating protects bacteria from macrophage phagocytosis, maintaining their activity for deep tumor drug delivery. And then, LOx and HRP can consume much L-lactate in the tumor site through an enzyme cascade reaction to improve the immunosuppressive environment, while causing oxidative stress and reduced ATP supply, thereby reversing AKT-mTOR metabolic pathway activation to inhibit tumor growth. More interestingly, LA not only acts as a natural enzyme's carrier, but also induces anti-inflammatory M2 macrophages to polarize into pro-inflammatory M1 macrophages by secreting D-lactate, enhancing antitumor immunotherapy. This engineered probiotic design provides a new idea for building a safe and efficient live bacteria delivery platform, providing a reference for developing cancer treatment strategies with clinical translation prospects.}, archive = {J_ADVS}, author = {Liuzhou Mao and Bahriman Xarpidin and Rui Shi and Yuting Lin and Haohua Hu and Caisheng Wu and Zheng Luo and Yun-Long Wu}, doi = {10.1002/advs.202417172}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2417172}, shortjournal = {Adv. Sci.}, title = {Natural enzyme-loaded polymeric stealth coating-armed engineered probiotics by disrupting tumor lactate homeostasis to synergistic metabolism-immuno-enzyme dynamic therapy}, volume = {12}, year = {2025}, }
• (2025). Regulation of PVT-CeA circuit in deoxynivalenol-induced anorexia and aversive-like emotions. ADVS, 12(16), 2417068. (www)

  @article{ , abstract = {Neuronal plasticity in the central amygdala (CeA) is essential for modulating feeding behaviors and emotional responses, potentially influencing reactions to Deoxynivalenol (DON). Acute oral administration of DON elicits a dose-responsive reduction in food intake, accompanied by pronounced alterations in locomotor activity and feeding frequency. This study investigates circuitry adaptations that mediate DON's effects on feeding, by targeting of GABA neurons in the CeA. Following exposure to DON, an increase in connectivity between the paraventricular nucleus of the thalamus (PVT) and CeA GABA neurons is observed, suggesting the involvement of this pathway in DON's adverse effects on feeding and emotional states. Chemogenetic and optogenetic manipulations of CeA GABA neurons resulted in substantial alterations in mice's feeding and overall activity. These findings suggest that CeA GABA neurons are involved in DON-induced anorexia and aversive-like emotional responses. Additionally, the administration of the SCN10A antagonist (A-803467) effectively mitigated DON-induced anorexia and aversive-like emotions, highlighting the pivotal role of the PVT-CeA circuit and CeA GABA neurons in regulating the physiological and emotional impacts of DON. These findings have significant implications for public health and clinical interventions, offering potential therapeutic strategies to mitigate DON's adverse effects on human health.}, archive = {J_ADVS}, author = {Liu-Nan Yang and Mingmeng Tang and Andreas K. Nüssler and Liegang Liu and Wei Yang}, doi = {10.1002/advs.202417068}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2417068}, shortjournal = {Adv. Sci.}, title = {Regulation of PVT-CeA circuit in deoxynivalenol-induced anorexia and aversive-like emotions}, volume = {12}, year = {2025}, }
• (2025). Exciton-photon coupling microcavity as a selective biosensing platform for nonlocal terahertz metamaterials. ADVS, 12(16), 2416951. (www)

  @article{ , abstract = {The strong-coupling microcavity between excitons and photons facilitates efficient modulation and control of light, as well as precise manipulation of photon propagation properties. This phenomenon demonstrates significant potential for diverse applications in quantum information processing, optical sensing, and nonlinear optics. The anapole, as a specific type of captured state, allows for effective control over the electromagnetic field through appropriate distributions of current and charge, generating substantial localized effects within the field. This mechanism provides a novel avenue for investigating the strong-coupling dynamics between photons and excitons in hybrid metamaterial sensing. Here, the rate of energy exchange between the excitons and the optical microcavity of the metamaterial is greater than their individual dissipation rates, resulting in significant Rabi splitting phenomena and pronounced anti-crossing behavior, ultimately forming an “ultrasensitive photoreactive region” suitable for sensing applications. Furthermore, the nonlocal metamaterial, characterized by strong light-matter coupling, can be integrated with functionalized colloidal gold and monoclonal tag antibodies to enable rapid multidimensional detection and identification of total prostate-specific antigen (tPSA) in complex environmental solutions. The proposed strong-coupling resonance microcavity plays a crucial role in the rapid evolution of nonlocal metamaterials, enhancing their applicability in molecular detection and selective recognition of fundamental light-matter interaction phenomena.}, archive = {J_ADVS}, author = {Guifang Wu and Fengping Yan and Lanju Liang and Xuemei Du and Wei Wang and Ting Li and Junping Tian and Xin Yan and Haiyun Yao and Ziqun Wang and Meng Wang}, doi = {10.1002/advs.202416951}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416951}, shortjournal = {Adv. Sci.}, title = {Exciton-photon coupling microcavity as a selective biosensing platform for nonlocal terahertz metamaterials}, volume = {12}, year = {2025}, }
• (2025). Bioinspired mechanisms and actuation of soft robotic crawlers. ADVS, 12(16), 2416764. (www)

  @article{ , abstract = {Inspired by soft-bodied animals, scientists and roboticists have explored and created soft materials and robots in this last decade to mimic the functionality and behavior of soft-crawling animals. Such effort has originated from the unique ability of soft structures to crawl effectively in complex natural environments. As a result, there is growing interest in the design of highly functional soft robotic crawlers through the creation of new flexible functional materials, understanding the underlying science of crawling mechanisms, and employing advanced actuation strategies. This review investigates the current state-of-the-art in this fascinating area to demonstrate the nexus between materials, mechanisms, actuation, and applications. Bioinspired crawling mechanisms of soft crawlers are initially outlined, which include two-anchor peristaltic and serpentine crawling and undulatory motion as analogs to caterpillars, worms, and snakes, respectively. The fabrication and use of new materials in the design of soft crawlers are also discussed, along with the exploitation of actuation mechanisms to achieve specific crawling locomotion. Finally, insights into future research directions are outlined.}, archive = {J_ADVS}, author = {Min Pan and Miaomiao Liu and Jiayi Lei and Yunyi Wang and Changhong Linghu and Chris Bowen and K. Jimmy Hsia}, doi = {10.1002/advs.202416764}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416764}, shortjournal = {Adv. Sci.}, title = {Bioinspired mechanisms and actuation of soft robotic crawlers}, volume = {12}, year = {2025}, }
• (2025). Biological reinforced concrete for cartilage repair with 3D printing. ADVS, 12(16), 2416734. (www)

  @article{ , abstract = {The development of biomimetic cartilage constructs (BCCs) with natural extracellular matrix (ECM) microenvironments and topological cues to accelerate the reconstruction of natural articular cartilage (NAC) after injury is challenging due to its complex structure, low cellular content, and less vascularity. Inspired by concrete rebar structure, a biomimetic cartilage named “biological reinforced concrete” is fabricated, with collagen fiber orientation transitioning from parallel to perpendicular, replicating the ECM microenvironments and complex construct of NAC. 3D-printed ultrafine fiber networks (UFNs) served as a degradable “biorebars”, while a hybrid biohydrogel acted as “biocement”. The stem cells are utilized as “bioactive aggregates”. The biocement is developed by combining and screening various biohydrogels to mimic an ECM microenvironment conducive to the formation of NAC. By adjusting the fiber scale and spacing of the UFNs, the mechanical properties of the biomimetic cartilages are controlled to resemble those of NAC. Additionally, the UFNs guided the directed growth of cells and the orderly secretion of ECM. Subsequently, the developed BCCs are implanted into an osteochondral defect, and after 4 months, they successfully reconstructed the complex structure of cartilage with mechanical properties closely resembling those of NAC. The biological reinforced concrete offers a customizable and universal strategy for tissue regeneration.}, archive = {J_ADVS}, author = {Yuewei Chen and Tao Fu and Zhongfei Zou and Yanming Liu and Jianguo Zhu and Binhong Teng and Ke Yao and Haibin Li and Jiachun Li and Zhijian Xie and Yong He}, doi = {10.1002/advs.202416734}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416734}, shortjournal = {Adv. Sci.}, title = {Biological reinforced concrete for cartilage repair with 3D printing}, volume = {12}, year = {2025}, }
• (2025). Mitigating cellular dysfunction through contaminant reduction in synthetic circRNA for high-efficiency mRNA-based cell reprogramming. ADVS, 12(16), 2416629. (www)

  @article{ , abstract = {Synthetic circular RNA (circRNA) holds great promise for biomedical research and therapeutic applications, but impurities introduced during synthesis trigger innate immune responses and significantly compromise its efficacy. In this study, key immunogenic byproducts, including double-stranded RNA, 5′ triphosphates from uncircularized RNA, and hydrolyzed RNA fragments, are identified as impairing circRNA functionality via RNA-sensing pathways. To address this, a multi-step purification process is developed that combines enzymatic treatments and cellulose-based filtration to effectively remove these contaminants. This approach significantly reduces immune activation and increases manufacturing yields of circRNA by over 10-fold. The purified circRNA demonstrates exceptional performance in induced pluripotent stem cells (iPSCs) reprogramming, achieving over 300% reprogramming efficiency with just three OSKMLN circRNA transfection treatments. Additionally, the purified circRNA achieves high levels and persistent expression of chimeric antigen receptor (CAR) in T cells with high cytotoxicity against tumor cells, making it a promising candidate for mRNA-based CAR-T cell therapy. These findings establish the purification strategy as a scalable and reliable platform for producing therapeutic-grade RNA, with broad applications in mRNA-based cell reprogramming for regenerative medicine and cancer immunotherapy.}, archive = {J_ADVS}, author = {Ziwei Zhang and Weiyu Li and Xiangyu Ren and Dengwang Luo and Xiushuang Yuan and Li Yu and Daming Wang and Yuhong Cao}, doi = {10.1002/advs.202416629}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416629}, shortjournal = {Adv. Sci.}, title = {Mitigating cellular dysfunction through contaminant reduction in synthetic circRNA for high-efficiency mRNA-based cell reprogramming}, volume = {12}, year = {2025}, }
• (2025). Construction of a biomimetic tubular scaffold inspired by sea sponge structure: Sponge-like framework and cell guidance. ADVS, 12(16), 2416627. (www)

  @article{ , abstract = {Engineering hollow fibers with precise surface microstructures is challenging; yet, essential for guiding cells alignment and ensuring proper vascular tissue function. Inspired by Euplectella sponges, a novel strategy to engineer biomimetic hollow fibers with spiral surface microstructures is developed. Using oxidized bacterial cellulose, bacterial cellulose, and polydopamine, a “brick-and-mortar” scaffold is created through precise shear control during microfluidic coaxial spinning. The scaffold mimics natural extracellular matrices, providing mechanical stability and supporting cell growth. In vitro studies show successful co-culture of endothelial cells (ECs) and smooth muscle cells (SMCs), with SMCs aligning along spiral surface microstructures and ECs forming a confluent inner layer. In vivo implantation confirms biocompatibility, biodegradability, and low immunogenicity. This Euplectella -inspired scaffold presents a promising approach for vascular tissue engineering and regenerative medicine.}, archive = {J_ADVS}, author = {Si Meng and Nihuan Wu and Jie Fang and Yidan Yu and Xin Tang and Yihan Wang and Xiaokang Deng and Cheng Qi and Tiantian Kong and Tengda Ding and Zhou Liu}, doi = {10.1002/advs.202416627}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416627}, shortjournal = {Adv. Sci.}, title = {Construction of a biomimetic tubular scaffold inspired by sea sponge structure: Sponge-like framework and cell guidance}, volume = {12}, year = {2025}, }
• (2025). Biomimetic MOF nanocarrier-mediated synergistic delivery of mitochondria and anti-inflammatory miRNA to alleviate acute lung injury. ADVS, 12(16), 2416594. (www)

  @article{ , abstract = {Acute lung injury (ALI) is a clinically critical disease characterized by overwhelming inflammatory response and significant tissue damage with no specific treatment available currently. As a key player in the pathogenesis of ALI, macrophages are aberrantly activated and polarize toward the pro-inflammatory phenotypes, leading to overzealous inflammation and lung injury. Mitochondria is recognized as a crucial signaling hub governing macrophage function and polarization, deregulation of which is causatively related with defective metabolism of macrophages, deregulated inflammation, and hence ALI. Herein, an inflammation-responsive, biomimetic metal-organic framework (MOF) nanoplatform, termed a127/mito@ZIF@Ma is developed, which is sophistically designed for synergistic delivery of macrophage-derived mitochondria and anti-inflammatory miRNA-127 antagonist to resume pulmonary macrophages homeostasis and alleviate lung inflammation and injury. Notably, macrophage membrane encapsulation conferred the biomimetic MOF with enhanced transport efficacy both in vitro and in vivo. Therefore, the administration of the nanoparticles accordingly conferred a profound protection of mice against lung inflammation and injury induced by either bacterial or viral infection with unnoticeable tissue toxicity. The study thus devises a novel MOF-based nanosystem that integrates mitochondria transplantation and miRNA therapeutics, which may open a new avenue for treating ALI and relevant critical diseases.}, archive = {J_ADVS}, author = {Xin Shou and Changjiang Chen and Hangjie Ying and Zhiyun Liu and Lingyao Zeng and Qiujie Li and Lanjie Lei and Bingyong Mao and Wei Zhang and Shumao Cui and Liyun Shi}, doi = {10.1002/advs.202416594}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416594}, shortjournal = {Adv. Sci.}, title = {Biomimetic MOF nanocarrier-mediated synergistic delivery of mitochondria and anti-inflammatory miRNA to alleviate acute lung injury}, volume = {12}, year = {2025}, }
• (2025). Host plasma microenvironment in immunometabolically impaired HIV infection leads to dysregulated monocyte function and synaptic transmission ex vivo. ADVS, 12(16), 2416453. (www)

  @article{ , abstract = {Risk stratification using multi-omics data deepens understanding of immunometabolism in successfully treated people with HIV (PWH) is inadequately explained. A personalized medicine approach integrating blood cell transcriptomics, plasma proteomics, and metabolomics is employed to identify the mechanisms of immunometabolic complications in prolonged treated PWH from the COCOMO cohort. Among the PWHs, 44% of PWH are at risk of experiencing immunometabolic complications identified using the network-based patient stratification method. Utilizing advanced machine learning techniques and a Bayesian classifier, five plasma protein biomarkers; Tubulin Folding Cofactor B (TBCB), Gamma-Glutamylcyclotransferase (GGCT), Taxilin Alpha (TXLNA), Pyridoxal Phosphate Binding Protein (PLPBP) and Large Tumor Suppressor Kinase 1 (LATS1) are identified as highly differentially abundant between healthy control (HC)-like and immunometabolically at-risk PWHs (all FDR<10 −10 ). The personalized metabolic models predict metabolic perturbations, revealing disruptions in central carbon metabolic fluxes and host tryptophan metabolism in at-risk phenotype. Functional assays in primary cells and cortical forebrain organoids (FBOs) further validate this. Metabolic perturbations lead to persistent monocyte activation, thereby impairing their functions ex vivo . Furthermore, the chronic inflammatory plasma microenvironment contributes to synaptic dysregulation in FBOs. The endogenous plasma inflammatory microenvironment is responsible for chronic inflammation in treated immunometabolically complicated at-risk PWH who have a higher risk of cardiovascular and neuropsychiatric disorders.}, archive = {J_ADVS}, author = {Flora Mikaeloff and Marco Gelpi and Alejandra Escós and Tianqi Wang and Soham Gupta and Anna Olofsson and Sara Svensson Akusjärvi and Sabrina Schuster and Prajakta Naval and Vikas Sood and Negin Nikouyan and Andreas D. Knudsen and Beate Vestad and Julie Høgh and Johannes R. Hov and Thomas Benfield and Marius Trøseid and Vinay Pawar and Marijana Rucevic and Rui Benfeitas and Ákos Végvári and Liam O'Mahony and Rajkumar Savai and Niklas K. Björkström and Magda Lourda and João Pedro de Magalhães and Siegfried Weiss and Adil Mardinoglu and Mukesh Kumar Varshney and Annika C. Karlsson and Yasir Ahmed Syed and Susanne D. Nielsen and Ujjwal Neogi}, doi = {10.1002/advs.202416453}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416453}, shortjournal = {Adv. Sci.}, title = {Host plasma microenvironment in immunometabolically impaired HIV infection leads to dysregulated monocyte function and synaptic transmission ex vivo}, volume = {12}, year = {2025}, }
• (2025). Electrically controlled metal-insulator heterogeneous evolution for infrared switch and perfect absorption. ADVS, 12(16), 2416420. (www)

  @article{ , abstract = {Active switching, which enables multifunctionality within a single optical component, is essential for reconfigurable infrared photonic systems such as radiation engineering, sensing, and communication. Metamaterials offer a solution but involve complex design and fabrication. A simpler approach with a planar layered structure becomes promising for offering economical manufacturing, easier integration, and scalability. However, it requires an active medium with giant tunability and effective modulation mechanisms. Here, an electrically controlled reversible infrared switching is demonstrated via a single layer of perovskite nickelate on an opaque substrate. Driven by the evolution of the refractive index during an electrically triggered proton-mediated metal-to-insulator transition, the device transforms from a high reflective ( R ≈0.74) to a low reflective state ( R ≈0.09) at λ = 7–10 µm. A temperature-independent perfect absorption ( A > 0.99 at λ = 11.6–12.1 µm) emerges in the partially hydrogenated state with the mixture of the metal and insulator phases, which results in a modulation of emissivity ≈0.623 at λ = 7–14 µm. The switching behavior is tunable over a wide temperature and wavelength range, offering a versatile path for adaptive infrared applications.}, archive = {J_ADVS}, author = {Xuefeng Cao and Jiahui Sun and Yuan Fang and Xurong Qiao and Shenghao Cai and Yuhao Qiu and Xuegang Chen and Yifei Sun and Jijie Huang and Xiangdong Ding and Jun Sun and Chenghao Wan and Zhen Zhang}, doi = {10.1002/advs.202416420}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416420}, shortjournal = {Adv. Sci.}, title = {Electrically controlled metal-insulator heterogeneous evolution for infrared switch and perfect absorption}, volume = {12}, year = {2025}, }
• (2025). Dynamic pathophysiological insight into the brain by NIR-II imaging. ADVS, 12(16), 2416390. (www)

  @article{ , abstract = {Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing the need for accurate and in vivo diagnostic tools that can afford valuable pathophysiological insight into the functioning of neurovascular unit in space and time. Currently, understanding of collateral perfusion and BBB evolution under both physiological and pathological conditions remains sparse, largely owing to limitations in methods for recording diminutive route of cerebral blood flow. Here, it is reported that highly crystalline semiconducting organic nanoprobes (named 4T-BSA) composed of small-molecule dye and bovine serum albumin showed vast potential for live-brain vascular imaging in the second near-infrared window (NIR-II, 1000–1700 nm). The 4T-BSA nanoprobes had superior imaging penetration depth in intact mouse brain with high signal-to-background ratio (SBR) of 6.0 and down to sub-50-µm spatial resolution of cerebral vasculature in three typical models of neurological pathophysiology. By visualizing the vascular collateral perfusion and albumin leakage, 4T-BSA nanoprobes identified the pathological activities of brain associated with the arterial/venous collateral flow network and BBB disruption. It is anticipated that NIR-II imaging of cerebral collateral circulation and BBB disruption will bring broad opportunities to address major medical challenges across timely, protective, and restorative interventions for neurological diseases.}, archive = {J_ADVS}, author = {Si Chen and Hao Chen and Xinxin Li and Shuqing He and Kangquan Shou and Kun Qian and Zhao Fang and Feng Gu and Baisong Chang and Zhen Cheng}, doi = {10.1002/advs.202416390}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416390}, shortjournal = {Adv. Sci.}, title = {Dynamic pathophysiological insight into the brain by NIR-II imaging}, volume = {12}, year = {2025}, }
• (2025). Construction of large-scale bioengineered hair germs and in vivo transplantation. ADVS, 12(16), 2416361. (www)

  @article{ , abstract = {Hair follicle (HF) regeneration technology holds promise for treating hair loss, but creating a biomimetic structure that mimics the natural follicle microenvironment remains challenging. Here a novel bioengineered hair germ (BHG) is developed using thermodynamically incompatible mucopolysaccharides to enhance HF regeneration efficiency. Mucopolysaccharide-based hydrogels are synthesized by grafting amino and diethylamino groups (dihydroxyphenylalanine-grafted hyaluronic acid (HME) hydrogels) for rapid gelation and strong wetting adhesion. Dual-layered microspheres are fabricated using a co-flow microfluidic system, with HME as the outer shell and gelatin methacrylate (GelMA) as the core, achieving thermodynamic incompatibility. The Wnt3a protein is encapsulated for sustained release. RNA sequencing, reverse transcription quantitative polymerase chain reaction (RT-qPCR), and functional validation are used to study the molecular mechanisms of HF regeneration. Results show that HME hydrogels exhibit excellent adhesion, shear-thinning behavior, and biocompatibility. The microspheres release Wnt3a for up to 9 days, with high-throughput sequencing revealing upregulation of HF regeneration genes like Ctnnb1 and Lef1 , and activation of the Wnt signaling pathway, while hypoxia-related genes such as Hif-1ɑ are downregulated. Pathway enrichment analyses confirm the enrichment of HF regeneration pathways. In conclusion, the HME-based BHG microspheres effectively promote in vivo HF regeneration, offering a promising solution for hair loss treatment and regeneration.}, archive = {J_ADVS}, author = {Yangpeng Chen and Yuhui Hou and Jiejian Chen and Jiaojiao Bai and Lijuan Du and Chen Qiu and Hanzhou Qi and Xuanbei Liu and Junfei Huang}, doi = {10.1002/advs.202416361}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416361}, shortjournal = {Adv. Sci.}, title = {Construction of large-scale bioengineered hair germs and in vivo transplantation}, volume = {12}, year = {2025}, }
• (2025). A dual-response DNA origami platform for imaging and treatment of sepsis-associated acute kidney injury. ADVS, 12(16), 2416330. (www)

  @article{ , abstract = {Current diagnostics for sepsis-associated acute kidney injury (SA-AKI) detect kidney damage only at advanced stages, limiting opportunities for timely intervention. A DNA origami-based nanoplatform is developed for the early diagnosis and treatment of SA-AKI. Modified with a fluorophore (Cy5) and quencher (BHQ3), the DNA origami remains nonfluorescent under normal conditions. During SA-AKI, elevated microRNA-21 triggers a strand displacement reaction that restores the fluorescence signal, enabling real-time detection. Additionally, the photoacoustic changes of BHQ3, driven by different excretion rates of the nanostructure and released DNA strands, enable dual-mode imaging, enhancing diagnostic accuracy. Therapeutically, DNA origami scavenges reactive oxygen species and, when conjugated with the antimicrobial peptide Leucine-Leucine-37 (LL-37), exhibits bactericidal effects. This combination boosts survival rates by 80% in SA-AKI models. This dual-response nanoplatform integrates precise imaging and targeted therapy, offering a powerful strategy for SA-AKI management and advancing applications of DNA origami in precision nanomedicine.}, archive = {J_ADVS}, author = {Yingying Zhao and Yadan Zhao and Yufan Ling and Zhiming Chen and Xiaofeng Wu and Xing Lu and Yao He and Houyu Wang and Fenglin Dong}, doi = {10.1002/advs.202416330}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416330}, shortjournal = {Adv. Sci.}, title = {A dual-response DNA origami platform for imaging and treatment of sepsis-associated acute kidney injury}, volume = {12}, year = {2025}, }
• (2025). Implanted microneedles loaded with sparfloxacin and zinc-manganese sulfide nanoparticles activates immunity for postoperative triple-negative breast cancer to prevent recurrence and metastasis. ADVS, 12(16), 2416270. (www)

  @article{ , abstract = {Recent investigations have underscored the significant role of manganese ions (Mn 2+ ) in immunization, particularly through the activation of the cGAS-STING pathway, which enhances antitumor immune responses. However, the rapid metabolism of free Mn 2+ following administration limits its effectiveness as an immune adjuvant. To address these challenges, microneedles (MNs) of hyaluronic acid containing Sparfloxacin (SP) and zinc-manganese sulfide (ZMS) are prepared for the postoperative in situ treatment of triple-negative breast cancer (TNBC) to prevent cancer recurrence and combat wound infection. ZMS/SP (ZS)-loaded MNs exhibit strong antimicrobial and antibiofilm properties that are crucial for preventing postoperative infections. Moreover, the generation of reactive oxygen species by these MNs disrupts the oxidative balance, effectively activating immunogenic cell death and facilitating the release of cytokines. ZS significantly suppressed tumor growth, reduced lung metastasis, and promoted wound healing. These effects are accompanied by notable increases in immune cell infiltration and activation, which is consistent with the gene sequencing results. Activation of the cGAS-STING pathway further improved antitumor immunity. These findings highlight the potential of ZS MNs as an effective and safe treatment that utilizes the immunostimulatory properties of Mn 2+ to enhance local and systemic immune responses for the prevention of postoperative TNBC metastasis.}, archive = {J_ADVS}, author = {Zhaoyou Chu and Wang Zheng and Wanyue Fu and Jun Liang and Wanni Wang and Lingling Xu and Xiaohua Jiang and Zhengbao Zha and Haisheng Qian}, doi = {10.1002/advs.202416270}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416270}, shortjournal = {Adv. Sci.}, title = {Implanted microneedles loaded with sparfloxacin and zinc-manganese sulfide nanoparticles activates immunity for postoperative triple-negative breast cancer to prevent recurrence and metastasis}, volume = {12}, year = {2025}, }
• (2025). Multi-shank 1024 channels active SiNAPS probe for large multi-regional topographical electrophysiological mapping of neural dynamics. ADVS, 12(16), 2416239. (www)

  @article{ , abstract = {Implantable active dense CMOS neural probes unlock the possibility of spatiotemporally resolving the activity of hundreds of single neurons in multiple brain circuits to investigate brain dynamics. Mapping neural dynamics in brain circuits with anatomical structures spanning several millimeters, however, remains challenging. Here, a CMOS neural probe advancing lateral sampling for mapping intracortical neural dynamics (both LFPs and spikes) in awake, behaving mice from an area >4 mm 2 is demonstrated. By taking advantage of SiNAPS technology modularity, an 8-shank probe with 1024 recording channels arranged in regular arrays of 128 electrodes/shank with an electrode pitch <30 µm is realized. Continuous low-noise recordings (spikes with 6.67 ± 1.02 µV RMS ) from all 1024 electrodes at 20 kHz/channel demonstrate the monitoring at high spatial and temporal resolution of a field of view spanning the 2D lattice of the entire mice hippocampal circuit, together with cortical and thalamic regions. This arrangement allows combining large population unit monitoring across distributed networks with precise intra- and interlaminar/nuclear mapping of the oscillatory dynamics.}, archive = {J_ADVS}, author = {Gian Nicola Angotzi and Mihály Vöröslakos and Nikolas Perentos and Joao Filipe Ribeiro and Matteo Vincenzi and Fabio Boi and Aziliz Lecomte and Gabor Orban and Andreas Genewsky and Gerrit Schwesig and Deren Aykan and György Buzsáki and Anton Sirota and Luca Berdondini}, doi = {10.1002/advs.202416239}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416239}, shortjournal = {Adv. Sci.}, title = {Multi-shank 1024 channels active SiNAPS probe for large multi-regional topographical electrophysiological mapping of neural dynamics}, volume = {12}, year = {2025}, }
• (2025). Simultaneous reversal of t lymphocytes and cancer cells metabolism via a biomimetic heavy-atom-free photosensitizers-based combination therapies to boost cancer photoimmunotherapy. ADVS, 12(16), 2416143. (www)

  @article{ , abstract = {Near-infrared (NIR) activated photosensitizers based on heavy-atom-free have great advantages in photoimmunotherapy, yet the tumor microenvironment often restricts their efficacy. To address this, a NIR-activated heavy-atom-free photosensitizer (named Cy-BF) is developed. Cy-BF is then encapsulated with phospholipids and platelet exosome vesicles to create platelet exosomes vesicles biomimetic and Cy-BF loaded hybrid liposomes (named CHL) Characterized by high phototoxicity, low dark toxicity, and enhanced tumor targeting, CHL demonstrates aggregation-induced broadening of absorption spectra and NIR (760 nm laser) activates photothermal therapy and type I photodynamic therapy. The CHL-mediated phototherapy induces mitochondrial damage and immunogenic cell death in tumor cells, decreases lactate production, and alters the tumor microenvironment by reducing regulatory T cells and increasing CD8 + T cells. To mitigate T cell inhibition by excess lactate, a combination therapy is introduced using lithium carbonate, which repurposes lactate as an energy source for CD8 + T cells, thereby enhancing the effectiveness of CHL-mediated photoimmunotherapy. This combination approach represents a novel strategy for reversing lactate metabolism in both tumor cells and T cells, paving the way for future clinical applications in photoimmunotherapy.}, archive = {J_ADVS}, author = {Yongjian Zhang and Xiaohong Wu and Kaiyuan Wang and Yaohan Tang and Xiuxin Lu and Fusheng Sun and Hua Tang and Xiaoyuan Chen and Shipeng Ning}, doi = {10.1002/advs.202416143}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2416143}, shortjournal = {Adv. Sci.}, title = {Simultaneous reversal of t lymphocytes and cancer cells metabolism via a biomimetic heavy-atom-free photosensitizers-based combination therapies to boost cancer photoimmunotherapy}, volume = {12}, year = {2025}, }
• (2025). Paternal obesity-induced H3K27me3 elevation leads to MANF-mediated transgenerational metabolic dysfunction in female offspring. ADVS, 12(16), 2415956. (www)

  @article{ , abstract = {Paternal lifestyle and environmental exposures can alter epigenetic changes in sperm and play a critical role in the offspring's future health, yet the underlying mechanisms remain elusive. The present study established a model of paternal obesity and found that the increased levels of H3K27me3 in sperm persist into the 8-cell embryo stage, resulting in a transgenerational decrease of Manf , which causes endoplasmic reticulum stress and activates the GRP78-PERK-EIF2α-ATF4-CHOP axis. This consequently leads to impaired glucose metabolism and apoptosis in the liver of female offspring. Based on these findings, the F0 mice are treated with 3-deazaneplanocin A, an EZH2 inhibitor, which successfully prevented metabolic dysfunction in F0 mice of the high-fat diet (HFD) group. Meanwhile, intravenous injection of recombinant human MANF in F1 female offspring can successfully rescue the metabolic dysfunction in the HFD-F1 group. These results demonstrate that paternal obesity triggers transgenerational metabolic dysfunction through sperm H3K27me3-dependent epigenetic regulation. The present study also identifies the H3K27me3-MANF pathway as a potentially preventive and therapeutic strategy for diabetes, although further studies are needed to validate its clinical applicability.}, archive = {J_ADVS}, author = {Yajun Shi and Weisheng Li and Xi Yu and Yan Zhao and Dan Zhu and Yueyang Song and Zejun Zhao and Yannan Gu and Bin Wei and Lingjun Li and Dongyi Yu and Pengjie Zhang and Qinqin Gao and Miao Sun}, doi = {10.1002/advs.202415956}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415956}, shortjournal = {Adv. Sci.}, title = {Paternal obesity-induced H3K27me3 elevation leads to MANF-mediated transgenerational metabolic dysfunction in female offspring}, volume = {12}, year = {2025}, }
• (2025). Heteroatom-synergistic effect on anchoring polysulfides in chalcone-linked nanographene covalent organic frameworks for high-performance Li─S batteries. ADVS, 12(16), 2415897. (www)

  @article{ , abstract = {Lithium-sulfur (Li─S) batteries are an attractive option for future energy storage devices because they offer higher theoretical specific capacity, energy density, and cost-effectiveness than commercial lithium-ion batteries. However, the practical applications of Li─S batteries are significantly limited by the shuttle effect caused by intermediate lithium polysulfides (LiPSs) and slow redox kinetics. In this study, the molecular engineering of chalcone-linked, sp 2 -bonded nanographene-type covalent organic frameworks (COFs) as sulfur hosts is reported to enhance interactions with LiPSs, thereby effectively suppressing the shuttle effect. The developed sulfur-hosting cathode material demonstrated outstanding battery performance, surpassing most reported materials by achieving a specific capacity of 1228 mA h g −1 at 0.5C, with 80% retention after 500 cycles and an average Coulombic Efficiency (C.E.) of 99%. Additionally, the mechanisms of sulfur immobilization, the subsequent conversion into lithium polysulfides (LiPSs), and their binding energies with COFs are investigated using density functional theory (DFT) calculations. These findings offer valuable insights into the structure-property relationships essential for developing more efficient sulfur-hosting cathodes.}, archive = {J_ADVS}, author = {Kayaramkodath Chandran Ranjeesh and Bharathkumar H. Javaregowda and Safa Gaber and Preeti Bhauriyal and Sushil Kumar and Tina Skorjanc and Matjaž Finšgar and Thomas Heine and Kothandam Krishnamoorthy and Dinesh Shetty}, doi = {10.1002/advs.202415897}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415897}, shortjournal = {Adv. Sci.}, title = {Heteroatom-synergistic effect on anchoring polysulfides in chalcone-linked nanographene covalent organic frameworks for high-performance Li─S batteries}, volume = {12}, year = {2025}, }
• (2025). MISP suppresses ferroptosis via MST1/2 kinases to facilitate YAP activation in non-small cell lung cancer. ADVS, 12(16), 2415814. (www)

  @article{ , abstract = {Despite advances in non-small cell lung cancer (NSCLC) therapies, resistance remains a major challenge. Ferroptosis, a form of regulated cell death, plays a key role in cancer progression and treatment response. However, the mechanisms governing ferroptosis in NSCLC are not fully understood. The Hippo pathway, which regulates cell proliferation, has recently been implicated in ferroptosis regulation. In this study, we identify Mitotic Spindle Positioning (MISP) as a critical inhibitor of ferroptosis in NSCLC. MISP is upregulated in NSCLC tissues, and its loss sensitizes cells to ferroptosis, reducing cell proliferation in vitro and in vivo. Mechanistically, MISP binds to the SARAH domain of MST1/2 kinases, inhibiting their homodimerization and autophosphorylation, leading to sustained activation of YAP, a transcriptional coactivator in the Hippo pathway. YAP activation increases SLC7A11 expression, which protects cells from ferroptosis. We also identify a mutant MISP-R390/391A that disrupts MISP-MST1/2 binding, further illustrating the MST1/2-dependent inhibition of Hippo signaling. Notably, MISP is a target of YAP, creating a feedback loop that amplifies YAP signaling. Our findings suggest a novel MISP-YAP axis regulating ferroptosis, positioning MISP as a potential therapeutic target for NSCLC, especially in cases with dysregulated YAP.}, archive = {J_ADVS}, author = {Fuquan Zhang and Bingtao Huang and Yiming Xu and Guohong Cao and Mingjing Shen and Changmin Liu and Judong Luo}, doi = {10.1002/advs.202415814}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415814}, shortjournal = {Adv. Sci.}, title = {MISP suppresses ferroptosis via MST1/2 kinases to facilitate YAP activation in non-small cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). Multimodal nanoplasmonic and fluorescence imaging for simultaneous monitoring of single-cell secretory and intracellular dynamics. ADVS, 12(16), 2415808. (www)

  @article{ , abstract = {Current imaging technologies are limited in their capability to simultaneously capture intracellular and extracellular dynamics in a spatially and temporally resolved manner. This study presents a multimodal imaging system that integrates nanoplasmonic sensing with multichannel fluorescence imaging to concomitantly analyze intracellular and extracellular processes in space and time at the single-cell level. Utilizing a highly sensitive gold nanohole array biosensor, the system provides label-free and real-time monitoring of extracellular secretion, while implementing nanoplasmonic-compatible multichannel fluorescence microscopy enables to visualize the interconnected intracellular activities. Combined with deep-learning-assisted image processing, this integrated approach allows multiparametric and simultaneous study of various cellular constituents in hundreds of individual cells with subcellular spatial and minute-level temporal resolution over extended periods of up to 20 h. The system's utility is demonstrated by characterizing a range of secreted biomolecules and fluorescence toolkits across three distinct applications: visualization of secretory behaviors along with subcellular organelles and metabolic processes, concurrent monitoring of protein expression and secretion, and assessment of cell cycle phases alongside their corresponding secretory profiles. By offering comprehensive insights, the multifunctional approach is expected to enhance holistic readouts of biological systems, facilitating new discoveries in both fundamental and translational sciences.}, archive = {J_ADVS}, author = {Saeid Ansaryan and Yung-Cheng Chiang and Yen-Cheng Liu and Patrick Reichenbach and Melita Irving and Hatice Altug}, doi = {10.1002/advs.202415808}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415808}, shortjournal = {Adv. Sci.}, title = {Multimodal nanoplasmonic and fluorescence imaging for simultaneous monitoring of single-cell secretory and intracellular dynamics}, volume = {12}, year = {2025}, }
• (2025). Nanoscale resist-free patterning of halogenated zeolitic imidazolate frameworks by extreme UV lithography. ADVS, 12(16), 2415804. (www)

  @article{ , abstract = {Advancements in patterning techniques for metal–organic frameworks (MOFs) are crucial for their integration into microelectronics. However, achieving precise nanoscale control of MOF structures remains challenging. In this work, a resist-free method for patterning MOFs is demonstrated using extreme ultraviolet (EUV) lithography with a resolution of 40 nm. The role of halogen atoms in the linker and the effect of humidity are analyzed through in situ and near-ambient pressure synchrotron X-ray photoelectron spectroscopy. In addition to facilitating the integration of MOFs, the results offer valuable insights for developing the highly sought-after positive-tone EUV photoresists.}, archive = {J_ADVS}, author = {Weina Li and Tianlei Ma and Pengyi Tang and Yunhong Luo and Hui Zhang and Jun Zhao and Rob Ameloot and Min Tu}, doi = {10.1002/advs.202415804}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415804}, shortjournal = {Adv. Sci.}, title = {Nanoscale resist-free patterning of halogenated zeolitic imidazolate frameworks by extreme UV lithography}, volume = {12}, year = {2025}, }
• (2025). Reprogramming the tumor immune microenvironment with ICAM-1-targeted Antibody‒Drug conjugates and b7-h3-CD3 bispecific antibodies. ADVS, 12(16), 2415577. (www)

  @article{ , abstract = {Reprogramming the tumor immune microenvironment (TIM) plays an important role in promoting the reversal of immune “cold” tumors into “hot” inflammatory tumors. Improving drug targeting, blocking immune checkpoints, and promoting the activation of immune cells are crucial for reprogramming the TIM. Here, an intercellular adhesion molecule 1-targeted antibody‒drug conjugate in combination with a B7-H3-CD3 bispecific antibody is selected for TIM reprogramming, which improved the efficacy of triple-negative breast cancer immunotherapy. This combination therapy improves drug targeting, blocks immune checkpoint pathways, and activates effector T cells to release cytokines, leading to immunogenic cell death and the release of tumor-associated antigens. This effect promotes the maturation of dendritic cells, infiltration and activation of cytotoxic CD8+ T cells, repolarization of M1-type macrophages, and reduction of M2-type macrophages, immune suppressor Tregs, and MDS cells, thereby reprogramming the TIM. In addition, this innovative strategy promotes the accumulation of immune cells at metastasis sites and significantly impedes the progression of lung metastatic lesions. Overall, this study provides novel insights for reprogramming the TIM using novel immunotherapeutic strategies that leverage the synergistic effects of antibody-drug conjugates and bispecific antibodies.}, archive = {J_ADVS}, author = {Shoubing Zhou and Mengyu Hong and Dan Zhao and Wenyu Li and Xiaolong Yuan and Yinghong Wang and Hualong Li and Yang Yang and Tengchuan Jin and Jing Pan}, doi = {10.1002/advs.202415577}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415577}, shortjournal = {Adv. Sci.}, title = {Reprogramming the tumor immune microenvironment with ICAM-1-targeted Antibody‒Drug conjugates and b7-h3-CD3 bispecific antibodies}, volume = {12}, year = {2025}, }
• (2025). Mannose-glycated metal-phenolic microcapsules orchestrate phenotype switch of macrophages for boosting tumor immunotherapy. ADVS, 12(16), 2415565. (www)

  @article{ , abstract = {Microcapsules are advancing in immunotherapy, with both their core and shell being capable of loading immunoregulatory substances. Notably, microcapsules with intrinsic bioactivities can more directly modulate the immune microenvironment, while current research in this area remains scarce. Herein, immunomodulatory metal-phenolic microcapsules (mMPMs) is developed through the one-step assembly of dopamine-modified hyaluronic acid (HADA) and Fe III onto mannose-glycated bovine serum albumin microbubbles (Man-BSA MBs). Specifically, Man-BSA formed during the early stages of the Maillard reaction is sonicated to produce microbubbles as templates for capsule preparation. Subsequently, HADA is rapidly coated on the templates and coordinates with Fe III to form microcapsules after air escapes from MBs. Mass spectrometry analysis identifies abundant lysine glycation sites on Man-BSA, with the highest glycation site percentage reaching 94.88%. Man-BSA within mMPMs effectively promotes macrophage internalization, induces the accumulation of pro-inflammatory mediators, and thereby results in the M1 polarization of macrophages, as further corroborated by proteomic analysis. Consequently, the compelling anti-tumor effects of mMPMs are demonstrated both in vitro and in vivo. Overall, this work presents an immunomodulatory microcapsule that activates pro-inflammatory phenotype macrophages, which is a promising microcarrier to improve immunotherapeutic effects.}, archive = {J_ADVS}, author = {Xin Tan and Renwang Sheng and Weikun Li and Yinghua Tao and Zonghao Liu and Ning Yang and Syeda Safia Hashmi and Feiling Feng and Fangzhou Liu and Liqin Ge}, doi = {10.1002/advs.202415565}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415565}, shortjournal = {Adv. Sci.}, title = {Mannose-glycated metal-phenolic microcapsules orchestrate phenotype switch of macrophages for boosting tumor immunotherapy}, volume = {12}, year = {2025}, }
• (2025). 2D metalorganic ferromagnets. ADVS, 12(16), 2415266. (www)

  @article{ , abstract = {Low-dimensional materials exhibiting stable magnetic ordering are interesting from a fundamental point of view as well as for future application in information technologies. Metalorganic magnets, created by linking metal atoms with specific organic molecules, allow adjustments to their properties by synthetically modifying the structure of these molecules or the way they connect to the metal atoms. Here, the study details the formation, structure, and magnetic behavior of a single-layer 2D metalorganic coordination network made of Ni atoms and tetracyanoethylene (TCNE) molecules (2D Ni-TCNE). Single-layer crystal domains of this 2D material are achieved by codeposition Ni atoms and TCNE on a Au(111) surface kept in vacuum. Non-contact atomic force microscopy visualizes the structure with atomic resolution. X-ray magnetic circular dichroism establishes the 2D NiTCNE as a ferromagnet, with high magnetic remanence and a coercive field of ≈1 tesla at 3 kelvin. The Curie temperature is between 10 and 20 kelvin. Metalorganic chemistry opens a large variety of routes of synthesis and it is anticipated that this materials research paves the way to new magnetic nanomaterials for spintronic applications.}, archive = {J_ADVS}, author = {Egzona Isufi Neziri and Céline Hensky and Hien Quy Le and Diego Radillo Ochoa and Aleksandra Cebrat and Manfred Parschau and Karl-Heinz Ernst and Christian Wäckerlin}, doi = {10.1002/advs.202415266}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415266}, shortjournal = {Adv. Sci.}, title = {2D metalorganic ferromagnets}, volume = {12}, year = {2025}, }
• (2025). High-speed hyperspectral imaging for near infrared fluorescence and environmental monitoring. ADVS, 12(16), 2415238. (www)

  @article{ , abstract = {Hyperspectral imaging captures both spectral and spatial information from a sample but is intrinsically slow. The near infrared (NIR, > 800 nm) is advantageous for imaging applications because it falls into the tissue transparency window and also contains vibrational overtone and combination modes useful for molecular fingerprinting. Here, fast hyperspectral NIR imaging is demonstrated using a spectral phasor transformation (HyperNIR). A liquid crystal variable retarder (LCVR) is used for tunable, wavelength-dependent sine- and cosine-filtering that transforms optical signals into a 2D spectral (phasor) space. Spectral information is thus obtained with just three images. The LCVR can be adjusted to cover a spectral range from 900 to 1600 nm in windows tunable from 50 to 700 nm, which enables distinguishing NIR fluorophores with emission peaks less than 5 nm apart. Furthermore, label-free hyperspectral NIR reflectance imaging is demonstrated to identify plastic polymers and monitor in vivo plant health. The approach uses the full camera resolution and reaches hyperspectral frame rates of 0.2 s −1 , limited only by the switching rate of the LCVR. HyperNIR facilitates straightforward hyperspectral imaging for applications in biomedicine and environmental monitoring.}, archive = {J_ADVS}, author = {Jan Stegemann and Franziska Gröniger and Krisztian Neutsch and Han Li and Benjamin Scott Flavel and Justus Tom Metternich and Luise Erpenbeck and Poul Bering Petersen and Per Niklas Hedde and Sebastian Kruss}, doi = {10.1002/advs.202415238}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415238}, shortjournal = {Adv. Sci.}, title = {High-speed hyperspectral imaging for near infrared fluorescence and environmental monitoring}, volume = {12}, year = {2025}, }
• (2025). Metabolomic and cellular mechanisms of drug-induced ototoxicity and nephrotoxicity: Therapeutic implications of uric acid modulation. ADVS, 12(16), 2415041. (www)

  @article{ , abstract = {Certain medications, including cisplatin and neomycin, often cause both hearing loss and renal dysfunction. This study aims to uncover the common mechanisms behind drug-induced ototoxicity and nephrotoxicity to aid early diagnosis and treatment. Metabolomic analyses reveal simultaneous disruptions in endogenous metabolic networks in the kidney, inner ear, and serum after administrating cisplatin or neomycin. Notably, a marked elevation in uric acid (UA), a recognized indicator of renal tubular injury, is identified. Supplementing UA and inhibiting its renal excretion worsen hearing loss and hair cell damage. Single-cell nucleus sequencing and immunohistochemistry reveal major changes in xanthine oxidase and ABCG2 , crucial for UA metabolism, primarily in cochlear stria vascularis cells rather than hair cells. Cisplatin triggers a significant release of UA from stria vascularis cells, reaching concentrations sufficient to induce autophagy-dependent ferroptosis in hair cells. In a coculture system, targeted interventions against these two proteins in stria vascularis cells, through either pharmacological inhibition or genetic manipulation, markedly decrease the elevated UA release and the subsequent ferroptosis of hair cells. These findings suggest a metabolic connection between the inner ear and the kidney, highlighting the therapeutic potential of modulating UA to mitigate drug-induced nephrotoxicity and ototoxicity.}, archive = {J_ADVS}, author = {Suhan Guo and Cheng Cheng and Yunhao Wu and Kaidi Shen and Depeng Zhang and Bin Chen and Xinyu Wang and Luping Shen and Qixiang Zhang and Renjie Chai and Guangji Wang and Fang Zhou}, doi = {10.1002/advs.202415041}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415041}, shortjournal = {Adv. Sci.}, title = {Metabolomic and cellular mechanisms of drug-induced ototoxicity and nephrotoxicity: Therapeutic implications of uric acid modulation}, volume = {12}, year = {2025}, }
• (2025). Discovery of a new phase in thin flakes of KV3Sb5 under pressure. ADVS, 12(16), 2415012. (www)

  @article{ , abstract = {Results of magnetotransport measurements are reported on KV 3 Sb 5 thin flakes under pressure. The zero-field electrical resistance reveals an additional anomaly emerging under pressure ( p ), marking a previously unidentified phase boundary T *( p ). Together with the established T CDW ( p ) and T c ( p ), denoting the charge-density-wave transition and a superconducting transition, respectively, the temperature-pressure phase diagram of KV 3 Sb 5 features a rich interplay among multiple phases. The Hall coefficient evolves reasonably smoothly when crossing the T * phase boundary compared with the variation when crossing T CDW , indicating the preservation of the pristine electronic structure. The mobility spectrum analysis provides further insights into distinguishing different phases. Finally, the high-pressure quantum oscillation studies up to 31 T combined with the density functional theory calculations further demonstrate that the new phase does not reconstruct the Fermi surface, confirming that the translational symmetry of the pristine metallic state is preserved.}, archive = {J_ADVS}, author = {Zheyu Wang and Lingfei Wang and King Yau Yip and Ying Kit Tsui and Tsz Fung Poon and Wenyan Wang and Chun Wai Tsang and Shanmin Wang and David Graf and Alexandre Pourret and Gabriel Seyfarth and Georg Knebel and Kwing To Lai and Wing Chi Yu and Wei Zhang and Swee K. Goh}, doi = {10.1002/advs.202415012}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2415012}, shortjournal = {Adv. Sci.}, title = {Discovery of a new phase in thin flakes of KV3Sb5 under pressure}, volume = {12}, year = {2025}, }
• (2025). Wearable standalone sensing systems for smart agriculture. ADVS, 12(16), 2414748. (www)

  @article{ , abstract = {Monitoring crops’ biotic and abiotic responses through sensors is crucial for conserving resources and maintaining crop production. Existing sensors often have technical limitations, measuring only specific parameters with limited reliability and spatial or temporal resolution. Wearable sensing systems are emerging as viable alternatives for plant health monitoring. These systems employ flexible materials attached to the plant body to detect nonchemical (mechanical and optical) and chemical parameters, including transpiration, plant growth, and volatile organic compounds, alongside microclimate factors like surface temperature and humidity. In smart farming, data from real-time monitoring using these sensors, integrated with Internet of Things technologies, can enhance crop production efficiency by supporting growth environment optimization and pest and disease management. This study examines the core components of wearable standalone systems, such as sensors, circuits, and power sources, and reviews their specific sensing targets and operational principles. It further discusses wearable sensors for plant physiology and metabolite monitoring, affordability, and machine learning techniques for analyzing multimodal sensor data. By summarizing these aspects, this study aims to advance the understanding and development of wearable sensing systems for sustainable agriculture.}, archive = {J_ADVS}, author = {Dongpil Kim and Mohammad Zarei and Siyoung Lee and Hansol Lee and Giwon Lee and Seung Goo Lee}, doi = {10.1002/advs.202414748}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2414748}, shortjournal = {Adv. Sci.}, title = {Wearable standalone sensing systems for smart agriculture}, volume = {12}, year = {2025}, }
• (2025). Lactobacillus johnsonii generates cyclo(pro-trp) and promotes intestinal ca2+ absorption to alleviate CKD–SHPT. ADVS, 12(16), 2414678. (www)

  @article{ , abstract = {Patients with chronic kidney disease (CKD) are at a high risk of developing secondary hyperparathyroidism (SHPT), which may cause organ dysfunction and increase patient mortality. The main clinical interventions for CKD–SHPT involve calcium supplements to boost absorption, but ineffective for some patients, and the reasons remain unclear. Here, CKD mice are divided into high and low groups based on intact parathyroid hormone (iPTH) levels. The high group exhibits significant changes in gut microbes, including a decrease in Lactobacillus , an increase in parathyroid hyperplasia, and a decrease in intestinal calcium. Fecal microbiota transplantation and L. johnsonii colonization indicate a link between gut microbes and CKD–SHPT. Clinically, higher L. johnsonii levels are correlated with milder hyperparathyroidism CKD–SHPT. The receiver operating characteristic (ROC) curve for L. johnsonii abundance and surgical risk is 0.81, with the calibration curve confirming predictive accuracy, and decision curve analysis revealing good clinical applicability. In vivo and in vitro experiments show that cyclo(pro-trp) enhance calcium inflow and lower iPTH levels in intestinal epithelial cells via a calcium-sensing receptor and transient receptor potential vanilloid 4 pathways. This study identified the crucial role of L. johnsonii in CKD–SHPT, unveiling a new mechanism for calcium imbalance and offering novel strategies for SHPT treatment and drug development.}, archive = {J_ADVS}, author = {Xiong Zeng and Lihua Sun and Huichao Xie and Shenhai Gong and Caibao Lu and Zhongwei Xu and Haidi Guan and Ben Han and Wei Wang and Zhengmin Zhang and Jieying Zhou and Shuai Wang and Yihui Chen and Weidong Xiao}, doi = {10.1002/advs.202414678}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2414678}, shortjournal = {Adv. Sci.}, title = {Lactobacillus johnsonii generates cyclo(pro-trp) and promotes intestinal ca2+ absorption to alleviate CKD–SHPT}, volume = {12}, year = {2025}, }
• (2025). Dual-gating strategy: Ultrasound activation of TRPV2 channels and borate-glass-induced calcium overload for tumor suppression. ADVS, 12(16), 2414676. (www)

  @article{ , abstract = {Effective and precise treatment of breast cancer, particularly with bone metastasis, remains a significant challenge. Here, a dual-gating strategy combining locally delivered borate glass (BG) and ultrasound (US) is developed for the precise and effective inhibition of breast cancer by targeting transient receptor potential vanilloid 2 (TRPV2). The results demonstrate that after local delivery of BG to the solid tumor, US effectively triggers calcium overload by activating the overexpressed TRPV2 channels, leading to mitochondrial autophagy and apoptosis in breast cancer cells, thereby inhibiting tumor growth with high precision. These effects are validated in subcutaneous, orthotopic, and TRPV2-overexpressing breast cancer mouse models. In the bone metastasis model, BG combined with US treatment simultaneously suppresses tumor growth and promotes bone regeneration. Overall, this dual-gating strategy offers a safe and efficient approach for the precise treatment of cancers with high TRPV2 expression and provides new insights into the design and clinical translation of calcium-overload-based cancer therapies.}, archive = {J_ADVS}, author = {Haihong Zhu and Liping Ouyang and Yangguang Huang and Ji Tan and Chunyu Liu and Qian Wang and Rongkun Huang and Wing Tak Wong and Xuanyong Liu and Haobo Pan and Yun Liao}, doi = {10.1002/advs.202414676}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2414676}, shortjournal = {Adv. Sci.}, title = {Dual-gating strategy: Ultrasound activation of TRPV2 channels and borate-glass-induced calcium overload for tumor suppression}, volume = {12}, year = {2025}, }
• (2025). SENP3 drives abdominal aortic aneurysm development by regulating ferroptosis via de-SUMOylation of CTH. ADVS, 12(16), 2414500. (www)

  @article{ , abstract = {Abdominal aortic aneurysm (AAA) is a high-risk inflammatory disorder. SENP3, a SUMO2/3-specific protease, is closely involved in the development of cancer. In this study, the aim is to explore the role of SENP3 in macrophages in AAA. It is found that the protein expression of SENP3 is significantly upregulated in both human and murine AAA specimens. SENP3 expression is negatively regulated by the E3 ubiquitin ligase STUB1/CHIP. Furthermore, myeloid-specific SENP3 knockout inhibited AAA formation in both AngII- and CaCl 2 -induced mouse models. SENP3 deficiency repressed AAA lesion macrophage infiltration and inflammatory response. Mechanistic studies identified Cystathionine Gamma–Lyase (CTH), a critical enzyme involved in hydrogen sulfide production, as a target protein of SENP3 that mediated the exacerbating effects of SENP3 on ferroptosis and inflammatory programs in macrophages. SUMO-3 modification at Lysine 361 promoted CTH protein stability, whereas de-SUMOylation by SENP3 facilitated its proteasome-dependent degradation. Most importantly, it is found that CTH inhibitor counteracted the protective effect of SENP3 deficiency on AAA. Additionally, supplementation with ATB346, a novel H 2 S-donating naproxen derivative, prevented AAA development in mice. These studies suggest that SENP3-mediated CTH deSUMOylation regulates macrophage ferroptosis and AAA development. The SENP3/CTH axis is therefore an important therapeutic target for aortic aneurysmal diseases.}, archive = {J_ADVS}, author = {Long Chen and Zhaohua Cai and Danrui Xiao and Yiping Shi and Qingqing Xiao and Min Liang and Yangjing Jiang and Yijie Huang and Feng Liang and Guo Zhou and Fei Zhuang and Xia Wang and Huanhuan Huo and Liang Fang and Qin Shao and Ben He}, doi = {10.1002/advs.202414500}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2414500}, shortjournal = {Adv. Sci.}, title = {SENP3 drives abdominal aortic aneurysm development by regulating ferroptosis via de-SUMOylation of CTH}, volume = {12}, year = {2025}, }
• (2025). Accumulation of damaging lipids in the arf1-ablated neurons promotes neurodegeneration through releasing mtDNA and activating inflammatory pathways in microglia. ADVS, 12(16), 2414260. (www)

  @article{ , abstract = {Lipid metabolism disorders in both neurons and glial cells have been found in neurodegenerative (ND) patients and animal models. However, the pathological connection between lipid droplets and NDs remains poorly understood. The recent work has highlighted the utility of a neuron-specific Arf1-knockout mouse model and corresponding cells for elucidating the nexus between lipid metabolism disorders and amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). In this study, it is found that Arf1 deficiency first induced surplus fatty acid synthesis through the AKT-mTORC1-SREBP1-FASN axis, which further triggered endoplasmic reticulum (ER)-mitochondrial stress cascade via calcium flux. The organelle stress cascade further caused mitochondrial DNA (mtDNA) to be released into cytoplasm. Concurrently, the FASN-driven fatty acid synthesis in the Arf1-deficient neurons might also induce accumulation of sphingolipids in lysosomes that caused dysfunction of autophagy and lysosomes, which further promoted lysosomal stress and mitochondria-derived extracellular vesicles (MDEVs) release. The released MDEVs carried mtDNA into microglia to activate the inflammatory pathways and neurodegeneration. The studies on neuronal lipid droplets (LDs) and recent studies of microglial LDs suggest a unified pathological function of LDs in NDs: activating the inflammatory pathways in microglia. This finding potentially provides new therapeutic strategies for NDs.}, archive = {J_ADVS}, author = {Xu Li and Shuhan Jin and Danke Wang and Ying Wu and Xiaoyu Tang and Yufan Liu and Tiange Yao and Shoufa Han and Lin Sun and Yuetong Wang and Steven X. Hou}, doi = {10.1002/advs.202414260}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2414260}, shortjournal = {Adv. Sci.}, title = {Accumulation of damaging lipids in the arf1-ablated neurons promotes neurodegeneration through releasing mtDNA and activating inflammatory pathways in microglia}, volume = {12}, year = {2025}, }
• (2025). A tailored hydrogel with local glycemia management, antioxidant activity, and photothermal antibacterial properties for diabetic wound healing. ADVS, 12(16), 2414161. (www)

  @article{ , abstract = {The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is developed to promote diabetic wound healing. This dressing is constructed by co-loading gold-cerium oxide (AuCeO 2 ) dumbbells and glucose oxidase (GOx) into a reactive oxygen species (ROS)-sensitive hydrogel matrix (ACG gels). In this system, Au-CeO 2 dumbbells effectively eliminate ROS, protecting cells from oxidative stress-induced damage while exhibiting significant near-infrared photothermal antibacterial activity. Additionally, the controlled release of GOx decreases blood glucose levels in the wound microenvironment, alleviating oxidative stress and inhibiting bacterial growth proliferation, thereby expediting the healing process. ACG gels demonstrated excellent wound healing-promoting properties in two in vivo wound models, providing a promising and effective platform for diabetic wound management.}, archive = {J_ADVS}, author = {Bangguo Zhou and Yangying Duan and Wenhao Li and Tao Chen and Jincheng Wang and Manting Cao and Guohao Lin and Ke Yang and Zhangqi Lai and Wencheng Wu}, doi = {10.1002/advs.202414161}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2414161}, shortjournal = {Adv. Sci.}, title = {A tailored hydrogel with local glycemia management, antioxidant activity, and photothermal antibacterial properties for diabetic wound healing}, volume = {12}, year = {2025}, }
• (2025). Tumor-adhesive chitosan-derived multi-immune agonist unleashes strong and durable anti-cancer immunity. ADVS, 12(16), 2414110. (www)

  @article{ , abstract = {The immunomodulation of the tumor microenvironment is critical for effective cancer immunotherapy, particularly for tumors that exhibit limited responses to conventional treatments. However, current immune agonists developed for tumor immunomodulation face several challenges, such as poor intratumoral retention, inadequate biocompatibility, and restricted cellular targets, which ultimately hamper their therapeutic efficacy and clinical application. In this study, a tumor-adhesive chitosan-tethered immune agonist construct (TACTIC) is introduced, which demonstrates good biocompatibility and robust immunostimulatory effects, enhancing the immunogenicity of tumor cells while simultaneously stimulating pro-inflammatory responses in various immune cell populations. Mechanistic investigations reveal that TACTIC targets multiple signaling pathways, conferring it to effectively remodel the irradiated tumor microenvironment, improve tumor control on murine cancer models post-radiotherapy, and elicit systemic immune responses with memory effects. The findings highlight the potential of TACTIC as a powerful macromolecular immune adjuvant, paving the way for its broader application in innovative cancer immunotherapies.}, archive = {J_ADVS}, author = {Huilan He and Liang Liu and Yun Zheng and Jinlong Ji and Li Cao and Chunlian Ye and Yu Sun and Ying Zhang and Zhiyuan Zhong}, doi = {10.1002/advs.202414110}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2414110}, shortjournal = {Adv. Sci.}, title = {Tumor-adhesive chitosan-derived multi-immune agonist unleashes strong and durable anti-cancer immunity}, volume = {12}, year = {2025}, }
• (2025). LIPUS promotes calcium oscillation and enhances calcium dependent autophagy of chondrocytes to alleviate osteoarthritis. ADVS, 12(16), 2413930. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a degenerative disease which places an enormous burden on society, effective treatments are still limited. As a non-invasive and safe physical therapy, low-intensity pulsed ultrasound (LIPUS) can alleviate OA progression, but the underlying mechanism is not fully understood, especially the mechanical transduction between LIPUS and the organism. In this pioneering study, the biomechanical effects of LIPUS on living mice chondrocytes and living body zebrafish are investigate by using fluorescence imaging technology, to dynamically “visualize” its invisible mechanical stimuli in the form of calcium oscillations. It is also confirmed that LIPUS maintains cartilage homeostasis by promoting chondrocyte autophagy in a calcium-dependent manner. In addition, chondrocyte ion channels are screened by scRNA-seq and confirm that the mechanosensitive ion channel transient receptor potential vanilloid 4 (TRPV4) mediated the biological effects of LIPUS on chondrocytes. Finally, it is found that a combination of pharmacologically induced and LIPUS-induced Ca 2+ influx in chondrocytes enhances the cartilage-protective effect of LIPUS, which may provide new insights for optimizing LIPUS in the treatment of OA.}, archive = {J_ADVS}, author = {Mengtong Guan and Xiaoyu Han and Bo Liao and Wang Han and Lin Chen and Bin Zhang and Xiuqin Peng and Yu Tian and Gongyi Xiao and Xinhe Li and Liang Kuang and Ying Zhu and Dingqun Bai}, doi = {10.1002/advs.202413930}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413930}, shortjournal = {Adv. Sci.}, title = {LIPUS promotes calcium oscillation and enhances calcium dependent autophagy of chondrocytes to alleviate osteoarthritis}, volume = {12}, year = {2025}, }
• (2025). A CLDN18.2-targeted nanoplatform manipulates magnetic hyperthermia spatiotemporally for synergistic immunotherapy in gastric cancer. ADVS, 12(16), 2413913. (www)

  @article{ , abstract = {Precision treatment of gastric cancer requires specific biomarkers, and CLDN18.2 emerges as a promising target for patients’ stratification and therapeutic guidance. In 563 cases, 54.4% of patients are identified as CLDN18.2-positive, with CLDN18.2 expression negatively correlated with immune-related factors like PD-L1, indicating a “cold” tumor microenvironment. Here, a novel CLDN18.2 monoclonal antibody 1D5 is created with superior high specificity and affinity, and the antibody-dependent fluorescence-magnetic nanoparticle is developed for specific detection and magnetic hyperthermia (MHT). Under the assistance of sensitive fluorescence and deep-penetrating magnetic particle imaging for tracing and timing the optimal nanoparticle dosage, MHT induces robust immunogenic response via DNA mismatch repair and tumor-associated antigen release. It recruits CD11c + dendritic cells, compensates PD-1 in CD8 + T cells, and enhances CD86 + macrophage polarization. The combination of anti-PD-1 therapy increased TNF-α and IFN-γ secretion and further boosted the cytotoxic efficacy of CD8 + T cells. Excellent therapeutic efficacy is found simultaneously on cell-derived allografts and patient-derived xenografts based on this spatiotemporally manipulated strategy, presenting a therapeutic option for enhancing responsiveness to immunotherapy for CLDN18.2-positive individuals.}, archive = {J_ADVS}, author = {Xueying Wang and Hui Hui and Jing Han and Ting Guo and Yiding Wang and Lin Meng and Cong Chen and Jie He and Xiaoyong Guo and Fuyu Zhong and Hong Du and Jie Tian and Xiaofang Xing and Yang Du and Jiafu Ji}, doi = {10.1002/advs.202413913}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413913}, shortjournal = {Adv. Sci.}, title = {A CLDN18.2-targeted nanoplatform manipulates magnetic hyperthermia spatiotemporally for synergistic immunotherapy in gastric cancer}, volume = {12}, year = {2025}, }
• (2025). Revealing the transcriptional and metabolic characteristics of sebocytes based on the donkey cell transcriptome atlas. ADVS, 12(16), 2413819. (www)

  @article{ , abstract = {Worldwide, donkeys ( Equus asinus ) are valued for their meat and milk, and in China also for the medical value of their skin. Physiological characteristics are key to the donkey's adaptability, including their digestive, respiratory, and reproductive systems, which enable them to survive and work in a variety of environments. However, the understanding of donkey physiological characteristics at the cellular level remains poor. Thus, single-cell transcriptome sequencing is used to construct a detailed transcriptional atlas based on 20 tissues from the Dezhou donkey (in total 84 cell types and 275 050 high quality cells) to perform an in-depth investigation of molecular physiology. Cross-species and cross-tissue comparative analyses reveal SOX10 to be an evolutionally conserved regulon in oligodendrocytes and illuminate the distinctive transcriptional patterns of donkey sebocytes. Moreover, through multispecies skin metabolomics, highly abundant, species-specific metabolites in donkey skin are identified, such as arachidonic acid and gamma-glutamylcysteine, and the pivotal role of sebocytes in donkey skin metabolism is highlighted. In summary, this work offers new insights into the unique metabolic patterns of donkey skin and provides a valuable resource for the conservation of donkey germplasm and the advancement of selective breeding programs.}, archive = {J_ADVS}, author = {Yu Tian and Shuqin Liu and Hongtao Shi and Jianjun Li and Xinglong Wan and Yujiang Sun and Huayun Li and Ning Cao and Zhixi Feng and Teng Zhang and Junjie Wang and Wei Shen}, doi = {10.1002/advs.202413819}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413819}, shortjournal = {Adv. Sci.}, title = {Revealing the transcriptional and metabolic characteristics of sebocytes based on the donkey cell transcriptome atlas}, volume = {12}, year = {2025}, }
• (2025). Self-induced A-B-A structure enables efficient wide-bandgap perovskite solar cells and tandems. ADVS, 12(16), 2413749. (www)

  @article{ , abstract = {Wide-bandgap (WBG) perovskite solar cells (PSCs), due to their tunable bandgap, can be integrated into tandem cell configurations with narrow-bandgap solar cells to overcome the shockley-queisser (SQ) limitation. However, the main obstacles limiting their performance are poor crystallinity and light-induced halide segregation. To achieve high performance in WBG PSCs, this study reports a dual-molecule cooperative strategy involving the introduction of 1-benzyl-3-methylimidazolium bromide (BzMIM Br) as an additive and the introduction of 6-fluoropyrimidine-2,4- diamine (DMFP) as a passivation layer. DMFP self-induced penetration to the bottom of the perovskite, forming an A-B-A structure with BzMIM Br, through utilizing multisite integration with uncoordinated Pb 2+ , constructing internal molecular bridges. Research findings indicate that the A-B-A structure with uniform potential distribution can interact with the perovskite in a step-like manner, suppressing halide segregation, and replenishing the vacancy defects. Results demonstrate power conversion efficiencies (PCEs) of 22.77% and 18.54% for inverted PSCs with effective areas of 0.043 and 1.0 cm 2 , respectively. Unencapsulated devices retain 95% of initial efficiency after 1500 h of continuous illumination under one-sun equivalent conditions in a nitrogen atmosphere. Additionally, the PCE of the prepared semi-transparent WBG devices reached 19.60%, while the PCE of the 4-terminal all-perovskite tandem device reached 26.18%.}, archive = {J_ADVS}, author = {Xixi Yu and Yong Zhu and Kunpeng Li and Xiong Chang and Mengni Zhou and Zhewen Xie and Xing Zhu and Hua Wang and Wenhui Ma and Shaoyuan Li and Tao Zhu}, doi = {10.1002/advs.202413749}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413749}, shortjournal = {Adv. Sci.}, title = {Self-induced A-B-A structure enables efficient wide-bandgap perovskite solar cells and tandems}, volume = {12}, year = {2025}, }
• (2025). Tumor microenvironment on-A-chip and single-cell analysis reveal synergistic Stromal–Immune crosstalk on breast cancer progression. ADVS, 12(16), 2413457. (www)

  @article{ , abstract = {Solid tumors develop within a complex environment called the tumor microenvironment (TME), which is sculpted by the presence of other cells, such as cancer-associated fibroblasts (CAFs) and immune cells like macrophages (Mφs). Despite the presence of immune cells, tumor cells orchestrate a tumor-supportive environment through intricate interaction with the components of the TME. However, the specific mechanism by which this intercellular dialogue is regulated is not fully understood. To that end, the development of an organotypic 3D breast TME-on-a-chip (TMEC) model, integrated with single-cell RNA sequencing analysis, is reported to mechanistically evaluate the progression of triple-negative breast cancer (TNBC) cells in the presence of patient-derived CAFs and Mφs. Extensive functional assays, including invasion and morphometric characterization, reveal the synergistic influence of CAFs and Mφs on tumor cells. Furthermore, gene expression and pathway enrichment analyses identify the involvement of the KYNU gene, suggesting a potential immune evasion mechanism through the kynurenine pathway. Lastly, the pharmacological targeting of the identified pathway is investigated.}, archive = {J_ADVS}, author = {Kalpana Ravi and Yining Zhang and Lydia Sakala and Twinkle Jina Minette Manoharan and Barbara Pockaj and Joshua LaBaer and Jin G. Park and Mehdi Nikkhah}, doi = {10.1002/advs.202413457}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413457}, shortjournal = {Adv. Sci.}, title = {Tumor microenvironment on-A-chip and single-cell analysis reveal synergistic Stromal–Immune crosstalk on breast cancer progression}, volume = {12}, year = {2025}, }
• (2025). Extracellular vesicle-packaged linc-ZNF25-1 from pancreatic cancer cell promotes pancreatic stellate cell uptake of asparagine to advance chemoresistance. ADVS, 12(16), 2413439. (www)

  @article{ , abstract = {Extensive fibrous stroma plays an important role in gemcitabine (GEM) resistance. However, the mechanism by which pancreatic cancer cells interact with pancreatic stellate cells (PSCs) to promote GEM resistance remains unclear. This study investigates the role of metabolic crosstalk between these two cells in inducing GEM resistance. Extracellular vesicles (EVs) of parental and GEM-resistant pancreatic cancer cells are extracted and performed metabolic assays and long noncoding RNA (lncRNA) sequencing. Pancreatic cancer cell-derived EVs promote PSCs activation and extracellular matrix formation, and GEM-resistant pancreatic cancer cells produce more asparagine (Asn), favoring PSCs activation. Mechanistically, pancreatic cancer cell-derived EVs mediate linc-ZNF25-1 to promote Asn uptake via the IGF2BP3/c-Myc/SLC1A5 pathway in PSCs. In addition, mouse models elucidate the oncogenic function of linc-ZNF25-1 and the enhanced therapeutic effect of asparaginase (L-ASNase) in combination with GEM in pancreatic cancer. This study demonstrates that pancreatic cancer cell-derived EVs promote the uptake of Asn released from pancreatic cancer cells through the upregulation of SLC1A5 in PSCs, facilitating PSCs activation and pancreatic cancer resistance to GEM. L-ASNase in combination with GEM is a potential therapeutic strategy for targeting stromal cells to enhance the efficacy of chemotherapeutic agents against pancreatic cancer.}, archive = {J_ADVS}, author = {Miao Yu and Mingxin Su and Zhenfeng Tian and Lele Pan and Zongmeng Li and Enlai Huang and Yinting Chen}, doi = {10.1002/advs.202413439}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413439}, shortjournal = {Adv. Sci.}, title = {Extracellular vesicle-packaged linc-ZNF25-1 from pancreatic cancer cell promotes pancreatic stellate cell uptake of asparagine to advance chemoresistance}, volume = {12}, year = {2025}, }
• (2025). Machine learning-enabled drug-induced toxicity prediction. ADVS, 12(16), 2413405. (www)

  @article{ , abstract = {Unexpected toxicity has become a significant obstacle to drug candidate development, accounting for 30% of drug discovery failures. Traditional toxicity assessment through animal testing is costly and time-consuming. Big data and artificial intelligence (AI), especially machine learning (ML), are robustly contributing to innovation and progress in toxicology research. However, the optimal AI model for different types of toxicity usually varies, making it essential to conduct comparative analyses of AI methods across toxicity domains. The diverse data sources also pose challenges for researchers focusing on specific toxicity studies. In this review, 10 categories of drug-induced toxicity is examined, summarizing the characteristics and applicable ML models, including both predictive and interpretable algorithms, striking a balance between breadth and depth. Key databases and tools used in toxicity prediction are also highlighted, including toxicology, chemical, multi-omics, and benchmark databases, organized by their focus and function to clarify their roles in drug-induced toxicity prediction. Finally, strategies to turn challenges into opportunities are analyzed and discussed. This review may provide researchers with a valuable reference for understanding and utilizing the available resources to bridge prediction and mechanistic insights, and further advance the application of ML in drugs-induced toxicity prediction.}, archive = {J_ADVS}, author = {Changsen Bai and Lianlian Wu and Ruijiang Li and Yang Cao and Song He and Xiaochen Bo}, doi = {10.1002/advs.202413405}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413405}, shortjournal = {Adv. Sci.}, title = {Machine learning-enabled drug-induced toxicity prediction}, volume = {12}, year = {2025}, }
• (2025). Prefrontal FGF1 signaling is required for accumbal deep brain stimulation treatment of addiction. ADVS, 12(16), 2413370. (www)

  @article{ , abstract = {Deep brain stimulation (DBS) has emerged as a prospective treatment for psychiatric disorders; for example, DBS targeting the nucleus accumbens (NAc) abolishes addictive behaviors. However, neither the core pathway nor the cellular mechanisms underlying these therapeutic effects are known. Here, morphine-induced conditioned place preference (CPP) in mice as an addiction model and NAc-DBS combined with adeno-associated virus gene delivery for activity-dependent tagging, transgenic and chemogenetic manipulation of recruited neuronal networks are used. It is reported that a cortical-accumbal pathway and local fibroblast growth factor 1 (FGF1) signaling in the medial prefrontal cortex (mPFC) are critical for NAc-DBS to be effective in altering morphine CPP. It is shown that NAc-DBS retrogradely activates mPFC neurons projecting to the NAc, and chemogenetic activation/inhibition of these DBS-activated neuron ensembles in the mPFC reproduces the NAc-DBS effects on CPP. Sustained therapeutic effects accompany reductions in local FGF1 binding to fibroblast growth factor receptor 1 (FGFR1) in these neurons. Additionally, overexpressing FGF1 in the mPFC-NAc pathway abolishes the therapeutic effects of NAc-DBS. These results demonstrate that the mPFC-NAc pathway forms a top-down motif to regulate the therapeutic effects of subcortical DBS on addiction. These results support the potential for addiction treatments involving FGF1 signaling and highlight the mPFC as a target for noninvasive brain stimulation.}, archive = {J_ADVS}, author = {Wan-Kun Gong and Xue Li and Le Wang and Qian Yang and Alix Tiran-Cappello and Zhichao Liang and James Samsom and Quanying Liu and He Lin and Christelle Baunez and Fang Liu and Ti-Fei Yuan}, doi = {10.1002/advs.202413370}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413370}, shortjournal = {Adv. Sci.}, title = {Prefrontal FGF1 signaling is required for accumbal deep brain stimulation treatment of addiction}, volume = {12}, year = {2025}, }
• (2025). Unwrapping the ciliary coat: High-resolution structure and function of the ciliary glycocalyx. ADVS, 12(16), 2413355. (www)

  @article{ , abstract = {The glycocalyx, a highly heterogeneous glycoprotein layer of cilia regulates adhesion and force transduction and is involved in signaling. The high-resolution molecular architecture of this layer is currently not understood. The structure of the ciliary coat is described in the green alga Chlamydomonas reinhardtii by cryo-electron tomography and proteomic approaches and the high-resolution cryoEM structure of the main component, FMG1B is solved. FMG1B is described as a mucin orthologue which lacks the major O -glycosylation of mammalian mucins but is N -glycosylated. FMG1A, a previously undescribed isoform of FMG1B is expressed in C. reinhardtii . By microflow-based adhesion assays, increased surface adhesion in the glycocalyx deficient double-mutant fmg1b-fmg1a is observed. It is found this mutant is capable of surface-gliding, with neither isoform required for extracellular force transduction by intraflagellar transport. The results find FMG1 to form a protective layer with adhesion-regulative instead of adhesion-conferring properties and an example of an undescribed class of mucins.}, archive = {J_ADVS}, author = {Lara M. Hoepfner and Adrian P. Nievergelt and Fabrizio Matrino and Martin Scholz and Helen E. Foster and Jonathan Rodenfels and Alexander von Appen and Michael Hippler and Gaia Pigino}, doi = {10.1002/advs.202413355}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413355}, shortjournal = {Adv. Sci.}, title = {Unwrapping the ciliary coat: High-resolution structure and function of the ciliary glycocalyx}, volume = {12}, year = {2025}, }
• (2025). Enhanced field-like torque generated from the anisotropic spin-split effect in triple-domain RuO2 for energy-efficient Spin–Orbit torque magnetic random-access memory. ADVS, 12(16), 2413165. (www)

  @article{ , abstract = {Spin-current generation via the anisotropic spin-split effect has been predicted in antiferromagnetic RuO 2 , where the symmetry of RuO 2 plays a critical role in spin–orbit torque (SOT). This phenomenon has garnered attention for its potential to enable energy-efficient spintronic devices, such as SOT magnetic random-access memory. In this study, a high-quality RuO 2 (100) epitaxial film with a well-controlled triple-domain-structure is analyzed, and it is confirmed that out-of-plane spin-current generation is independent of the Néel vector ( ). This independence of the out-of-plane spin current leads to equal SOT values for the two orthogonal currents. The spin-split effect-induced SOT demonstrates a field-like (FL) torque efficiency (−0.066 ± 0.001) that is six times higher than that of the Slonczewski-like torque efficiency (−0.011 ± 0.001). Furthermore, micromagnetic simulations show that this high FL torque reduces the critical switching voltage by a factor of 2.6 in the sub-nanosecond regime in an SOT device. These findings contribute to advancing research and the development of highly energy-efficient antiferromagnetic-based SOT magnetic random-access memory.}, archive = {J_ADVS}, author = {Thi Van Anh Nguyen and Hiroshi Naganuma and Thi Ngoc Huyen Vu and Samik DuttaGupta and Yoshiaki Saito and Duong Vu and Yasushi Endo and Shoji Ikeda and Tetsuo Endoh}, doi = {10.1002/advs.202413165}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413165}, shortjournal = {Adv. Sci.}, title = {Enhanced field-like torque generated from the anisotropic spin-split effect in triple-domain RuO2 for energy-efficient Spin–Orbit torque magnetic random-access memory}, volume = {12}, year = {2025}, }
• (2025). Actionable forecasting as a determinant of biological adaptation. ADVS, 12(16), 2413153. (www)

  @article{ , abstract = {Organisms continuously adapt to changing environments to survive. Here, contrary to the prevailing view that predictive strategies are essential for perfect adaptation, it is shown that biological systems can precisely track their optimal state by adapting to a non-anticipatory actionable target that integrates the current optimum with its rate of change. Predictive mechanisms, such as circadian rhythms, are beneficial for accurately inferring the actionable target when environmental sensing is slow or unreliable. A new mathematical framework is developed, showing that dynamics-informed neural networks embodying these principles can efficiently capture biological adaptation even in noisy environments. These results provide fundamental insights into the interplay between forecasting, control, and inference in biological systems, redefining adaptation strategies and guiding the design of advanced adaptive biomolecular circuits.}, archive = {J_ADVS}, author = {Jose M. G. Vilar and Leonor Saiz}, doi = {10.1002/advs.202413153}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413153}, shortjournal = {Adv. Sci.}, title = {Actionable forecasting as a determinant of biological adaptation}, volume = {12}, year = {2025}, }
• (2025). Mg-doped α-Ga2O3 nanorods for the construction of photoelectrochemical-type self-powered solar blind UV photodetectors and underwater imaging application. ADVS, 12(16), 2413074. (www)

  @article{ , abstract = {Underwater imaging technologies are increasingly crucial for environmental monitoring and resource exploration. However, the development of advanced photodetectors for such applications faces significant challenges, including interference from ambient visible and infrared light, adaptation to underwater environments, and cost-effectiveness. Photoelectrochemical-type solar-blind photodetectors (PEC-SBPDs) based on wide bandgap semiconductors have shown great promise in overcoming these challenges. Here, a novel approach to enhance the performance of α-Ga 2 O 3 -based PEC-SBPDs is presented for underwater imaging through Mg-doping. By employing a low-cost hydrothermal synthesis technique, Mg-doped α-Ga 2 O 3 nanorod arrays are fabricated, which induces the formation of V O -Mg Ga complexes that enhances the interfacial catalytic activity and improves the transport of photogenerated carriers. The optimized PEC-SBPDs exhibits a remarkable 435% increase in photocurrent response compared to undoped α-Ga 2 O 3 , with a peak responsivity of 34.54 mA W −1 . A 5 × 5 PEC-SBPD array based on Mg-doped α-Ga 2 O 3 nanorods is successfully demonstrated for underwater solar-blind imaging, achieving clear and efficient imaging in challenging underwater conditions. This study not only highlights the superior performance of Mg-doped α-Ga 2 O 3 in underwater environments but also opens new avenues for the development of high-performance self-powered photodetectors in imaging, sensing, and other related applications.}, archive = {J_ADVS}, author = {Xin Zhou and Lijuan Ye and Lai Yuan and Dan Zhang and Hong Zhang and Di Pang and Yan Tang and Honglin Li and Wanjun Li and Heping Zeng}, doi = {10.1002/advs.202413074}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413074}, shortjournal = {Adv. Sci.}, title = {Mg-doped α-Ga2O3 nanorods for the construction of photoelectrochemical-type self-powered solar blind UV photodetectors and underwater imaging application}, volume = {12}, year = {2025}, }
• (2025). Genomic insights into post-domestication expansion and selection of body size in ponies. ADVS, 12(16), 2413023. (www)

  @article{ , abstract = {Horse domestication revolutionizes human civilization by transforming transportation, agriculture, and warfare patterns. Despite extensive studies on modern domestic horse origins, the intricate demographic history and genetic signatures underlying pony size remain unexplored. Here, a high-quality genome assembly of the Chinese Debao pony is presented, and 452 qualified individuals from 64 horse breeds worldwide are extensively analyzed. The authors’ results reveal the conservation of ancient components in East Asian horses and close relationships between Asian horses and Western pony lineages. Genetic analyses suggest an Asian paternal origin for European pony breeds. These pony-sized horses share close genetic affinities, potentially attributed to their early expansion and adaptation to local environments. In addition, promising cis -regulatory elements influencing horse withers height by regulating genes such as RFLNA and FOXO1 are identified. Overall, this study provides insightful perspectives on the dispersal history and genetic determinants underlying body size in ponies, offering broader implications for horse population management and improvement.}, archive = {J_ADVS}, author = {Xingzheng Li and Zihao Wang and Min Zhu and Binhu Wang and Shaohua Teng and Jing Yan and Haoyu Wang and Pengxiang Yuan and Shuwei Cao and Xiaolu Qu and Zhen Wang and Kai Zhan and Md. Panir Choudhury and Xintong Yang and Qi Bao and Sang He and Lei Liu and Pengju Zhao and Jicai Jiang and Hai Xiang and Lingzhao Fang and Zhonglin Tang and Yuying Liao and Guoqiang Yi}, doi = {10.1002/advs.202413023}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2413023}, shortjournal = {Adv. Sci.}, title = {Genomic insights into post-domestication expansion and selection of body size in ponies}, volume = {12}, year = {2025}, }
• (2025). Medium spiny neurons mediate timing perception in coordination with prefrontal neurons in primates. ADVS, 12(16), 2412963. (www)

  @article{ , abstract = {Timing perception is a fundamental cognitive function that allows organisms to navigate their environment effectively, encompassing both prospective and retrospective timing. Despite significant advancements in understanding how the brain processes temporal information, the neural mechanisms underlying these two forms of timing remain largely unexplored. In this study, it aims to bridge this knowledge gap by elucidating the functional roles of various neuronal populations in the striatum and prefrontal cortex (PFC) in shaping subjective experiences of time. Utilizing a large-scale electrode array, it recorded responses from over 3000 neurons in the striatum and PFC of macaque monkeys during timing tasks. The analysis classified neurons into distinct groups and revealed that retrospective and prospective timings are governed by separate neural processes. Specifically, this study demonstrates that medium spiny neurons (MSNs) in the striatum play a crucial role in facilitating these timing processes. Through cell-type-specific manipulation, it identified D2-MSNs as the primary contributors to both forms of timing. Additionally, the findings indicate that effective processing of timing requires coordination between the PFC and the striatum. In summary, this study advances the understanding of the neural foundations of timing perception and highlights its behavioral implications.}, archive = {J_ADVS}, author = {Xinhe Liu and Zhiting Zhang and Lu Gan and Panke Yu and Ji Dai}, doi = {10.1002/advs.202412963}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2412963}, shortjournal = {Adv. Sci.}, title = {Medium spiny neurons mediate timing perception in coordination with prefrontal neurons in primates}, volume = {12}, year = {2025}, }
• (2025). Subsurface oxygen vacancy mediated surface reconstruction and depolarization of ferroelectric BaTiO3 (001) surface. ADVS, 12(16), 2412781. (www)

  @article{ , abstract = {The interplay between surface reconstruction and depolarization of ferroelectric oxide surfaces is strongly influenced by oxygen vacancies (V O ). Using in-situ atomic-resolution electron microscopy imaging and spectroscopy techniques, it is directly observed that a clean BaTiO 3 (001) surface stabilizes into (2 × 1) BaO-terminated reconstruction during vacuum annealing. This surface reconstruction is achieved with accommodating BaO deficiency and incorporates TiO x adunits. The cooperative atomic rumpling in both the surface and subsurface layers, arranged in a tail-to-tail configuration, is stabilized by planar accumulation of V O in the subsurface TiO 2 layer. This reduces the net polarization of surface unit cells, contributing to overall depolarization. Under this atomic rumpling, the polarization-down (P↓) state is energetically favored over the polarization-up (P↑) state, as the P↓ state requires less atomic relaxation in the bulk layers to achieve dipole inversion at the subsurface. The energetic preference for V O in the subsurface TiO 2 layer of the P↓ state is confirmed through calculations of V O formation energy and the energy barrier for surface-to-subsurface migration. These findings reveal that the presence of V O in the subsurface layer lifts the degeneracy in the double-well potential between the P↓ and P↑ states in BaTiO 3 (001).}, archive = {J_ADVS}, author = {Jeehun Jeong and Jaejin Hwang and Yaolong Xing and Zhipeng Wang and Jaekwang Lee and Sang Ho Oh}, doi = {10.1002/advs.202412781}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2412781}, shortjournal = {Adv. Sci.}, title = {Subsurface oxygen vacancy mediated surface reconstruction and depolarization of ferroelectric BaTiO3 (001) surface}, volume = {12}, year = {2025}, }
• (2025). High-conductivity, self-healing, and adhesive ionic hydrogels for health monitoring and human-machine interactions under extreme cold conditions. ADVS, 12(16), 2412726. (www)

  @article{ , abstract = {Ionic conductive hydrogels (ICHs) are emerging as key materials for advanced human-machine interactions and health monitoring systems due to their unique combination of flexibility, biocompatibility, and electrical conductivity. However, a major challenge remains in developing ICHs that simultaneously exhibit high ionic conductivity, self-healing, and strong adhesion, particularly under extreme low-temperature conditions. In this study, a novel ICH composed of sulfobetaine methacrylate, methacrylic acid, TEMPO-oxidized cellulose nanofibers, sodium alginate, and lithium chloride is presented. The hydrogel is designed with a hydrogen-bonded and chemically crosslinked network, achieving excellent conductivity (0.49 ± 0.05 S m −1 ), adhesion (36.73 ± 2.28 kPa), and self-healing capacity even at −80 °C. Furthermore, the ICHs maintain functionality for over 45 days, showcasing outstanding anti-freezing properties. This material demonstrates significant potential for non-invasive, continuous health monitoring, adhering conformally to the skin without signal crosstalk, and enabling real-time, high-fidelity signal transmission in human-machine interactions under cryogenic conditions. These ICHs offer transformative potential for the next generation of multimodal sensors, broadening application possibilities in harsh environments, including extreme weather and outer space.}, archive = {J_ADVS}, author = {Fei Han and Shumeng Chen and Fei Wang and Mei Liu and Jiahui Li and Hao Liu and Yanshen Yang and Haoqing Zhang and Dong Liu and Rongyan He and Wentao Cao and Xiaochuan Qin and Feng Xu}, doi = {10.1002/advs.202412726}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2412726}, shortjournal = {Adv. Sci.}, title = {High-conductivity, self-healing, and adhesive ionic hydrogels for health monitoring and human-machine interactions under extreme cold conditions}, volume = {12}, year = {2025}, }
• (2025). Photosensitivity and carrier densities of perovskite solar absorbers. ADVS, 12(16), 2412711. (www)

  @article{ , abstract = {Dark and light current–voltage characteristics of perovskite solar absorbers are analyzed in terms of their carrier densities. The analysis reveals p-type large polarons as a dominant carrier type in the investigated perovskite solar cells. The mechanism causing photosensitivity is attributed to the dissociation (and pairing) of bipolarons to large polarons (and vice versa) that are controlled by the internal potential Γ. As an example, the polaron concept is tested for a formamidinium lead triiodide perovskite solar cell. The individual steps of the data analysis are demonstrated and determine the ionicity factor of this perovskite film, quantify the density of the large polarons, and predict the gain and loss of photo-induced carriers. It is deduced that a reversible light-on/off operation can only occur when the bias voltage never exceeds a critical value of the internal potential. The results gained in this study suggest that the novel analysis can be successively applied on different hybrid perovskite materials, too.}, archive = {J_ADVS}, author = {Małgorzata Kot and Katarzyna Gawlińska-Nęcek and Emilia Pożarowska and Karsten Henkel and Dieter Schmeißer}, doi = {10.1002/advs.202412711}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2412711}, shortjournal = {Adv. Sci.}, title = {Photosensitivity and carrier densities of perovskite solar absorbers}, volume = {12}, year = {2025}, }
• (2025). DPImpute: A genotype imputation framework for ultra-low coverage whole-genome sequencing and its application in genomic selection. ADVS, 12(16), 2412482. (www)

  @article{ , abstract = {Whole-genome sequencing is pivotal for elucidating the complex relationships between genotype and phenotype. However, its widespread application is hindered by the high sequencing depth and large sample sizes required, especially for genomic selection (GS) reliant on precise phenotype prediction from high-density genotype data. To address this, DPImpute (Dual-Phase Impute) is developed, an two-step imputation pipeline enabling accurate whole-genome SNP genotyping under ultra-low coverage whole-genome sequencing (ulcWGS) depths, small testing sample sizes, and limited reference populations. DPImpute achieved 98.06% SNP imputation accuracy with minimal testing samples (≤10), reference samples (≤100), and an ultra-low sequencing depth of 0.3X, surpassing the accuracy of existing imputation methods. Moreover, this high accuracy is maintained across multi-ancestry human populations. Remarkably, DPImpute demonstrated accurate SNP imputation from low-coverage sequencing data from single blood cells and single blastocyst cells, highlighting its potential in embryo GS. To enhance the accessibility of DPImpute, a user-friendly web server ( https://agdb.ecenr.com/DPImpute/home ) is developed and a Docker container for seamless implementation. In summary, DPImpute can significantly expedite breeding programs through precise and cost-effective genotyping and serve as a valuable tool for diverse population genotyping, encompassing both human and animal studies.}, archive = {J_ADVS}, author = {Weigang Zheng and Wenlong Ma and Zhilong Chen and Chao Wang and Tao Sun and Wenjun Dong and Wenjing Zhang and Song Zhang and Zhonglin Tang and Kui Li and Yunxiang Zhao and Yuwen Liu}, doi = {10.1002/advs.202412482}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2412482}, shortjournal = {Adv. Sci.}, title = {DPImpute: A genotype imputation framework for ultra-low coverage whole-genome sequencing and its application in genomic selection}, volume = {12}, year = {2025}, }
• (2025). A knowledge-guided graph learning approach bridging phenotype- and target-based drug discovery. ADVS, 12(16), 2412402. (www)

  @article{ , abstract = {Discovering therapeutic molecules requires the integration of both phenotype-based drug discovery (PDD) and target-based drug discovery (TDD). However, this integration remains challenging due to the inherent heterogeneity, noise, and bias present in biomedical data. In this study, Knowledge-Guided Drug Relational Predictor (KGDRP), a graph representation learning approach is developed that effectively integrates multimodal biomedical data, including network data containing biological system information, gene expression data, and sequence data that incorporates chemical molecular structures, all within a heterogeneous graph (HG) structure. By incorporating biomedical HG (BioHG) into a heterogeneous graph neural network (HGNN)-based architecture, KGDRP exhibits a remarkable 12% improvement compared to previous methods in real-world screening scenarios. Notably, the biology-informed representation, derived from KGDRP, significantly enhance target prioritization by 26% in drug target discovery. Furthermore, zero-shot evaluation on COVID-19 exhibited a notably higher success rate in identifying diverse potential drugs. The utilization of BioHG facilitates a unique KGDRP-based analysis of cell-target-drug interactions, thereby enabling the elucidation of drug mechanisms. Overall, KGDRP provides a robust infrastructure for the seamlessly integration of multimodal data and biomedical networks, effectively accelerating PDD, guiding therapeutic target discovery, and ultimately expediting therapeutic molecule discovery.}, archive = {J_ADVS}, author = {Qing Ye and Yundian Zeng and Linlong Jiang and Yu Kang and Peichen Pan and Jiming Chen and Yafeng Deng and Haitao Zhao and Shibo He and Tingjun Hou and Chang-Yu Hsieh}, doi = {10.1002/advs.202412402}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2412402}, shortjournal = {Adv. Sci.}, title = {A knowledge-guided graph learning approach bridging phenotype- and target-based drug discovery}, volume = {12}, year = {2025}, }
• (2025). Positive feedback regulation between KLF5 and XPO1 promotes cell cycle progression of basal like breast cancer. ADVS, 12(16), 2412096. (www)

  @article{ , abstract = {Basal-like breast cancer (BLBC), overlapping with the subgroup of estrogen receptor (ER), progesterone receptor (PR), and HER2 triple-negative breast cancer, has the worst prognosis and limited therapeutics. The XPO1 gene encodes nuclear export protein 1, a promising anticancer target which mediates nucleus-cytoplasm transport of nuclear export signal containing proteins such as tumor suppressor RB1 and some RNAs. Despite drugs targeting XPO1 are used in clinical, the regulation of XPO1 expression and functional mechanism is poorly understood, especially in BLBC. This study finds that KLF5 is a transcription factor of XPO1 , which increases RB1 nuclear export and cell proliferation in BLBC cells. Furthermore, XPO1 interacts with the RNA-binding protein PTBP1 to export FOXO1 mRNA to cytoplasm and thus activates the FOXO1-KLF5 axis as a feedback. This work demonstrates that XPO1 inhibitor KPT-330 in combination with CDK4/6 inhibitor additively suppressed BLBC tumor growth in vivo. These results reveal a novel positive feedback regulation loop between KLF5 and XPO1 and provide a novel treatment strategy for BLBC.}, archive = {J_ADVS}, author = {Yu Tang and Rui Liu and Jing Zhu and Qian He and Chenglong Pan and Zhongmei Zhou and Jian Sun and Fubing Li and Longlong Zhang and Yujie Shi and Jing Yao and Dewei Jiang and Ceshi Chen}, doi = {10.1002/advs.202412096}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2412096}, shortjournal = {Adv. Sci.}, title = {Positive feedback regulation between KLF5 and XPO1 promotes cell cycle progression of basal like breast cancer}, volume = {12}, year = {2025}, }
• (2025). ScHeteroNet: A heterophily-aware graph neural network for accurate cell type annotation and novel cell detection. ADVS, 12(16), 2412095. (www)

  @article{ , abstract = {Single-cell RNA sequencing (scRNA-seq) has unveiled extensive cellular heterogeneity, yet precise cell type annotation and the identification of novel cell populations remain significant challenges. scHeteroNet, a novel graph neural network framework specifically designed to leverage heterophily in scRNA-seq data, is presented. Unlike traditional methods that assume homophily, scHeteroNet captures complex cell–cell interactions by integrating information from both immediate and extended cellular neighborhoods, resulting in highly accurate cell representations. Additionally, scHeteroNet incorporates an innovative novelty propagation mechanism that robustly detects previously uncharacterized cell types. Comprehensive evaluations across diverse scRNA-seq datasets demonstrate that scHeteroNet consistently outperforms state-of-the-art approaches in both cell type classification and novel cell detection. This heterophily-aware approach enhances the ability to uncover cellular diversity, providing deeper insights into complex biological systems and advancing the field of single-cell analysis.}, archive = {J_ADVS}, author = {Jiacheng Liu and Xingyu Fan and Chunbin Gu and Yaodong Yang and Bian Wu and Guangyong Chen and Chang-Yu Hsieh and Pheng-Ann Heng}, doi = {10.1002/advs.202412095}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2412095}, shortjournal = {Adv. Sci.}, title = {ScHeteroNet: A heterophily-aware graph neural network for accurate cell type annotation and novel cell detection}, volume = {12}, year = {2025}, }
• (2025). NETs-CD44-IL-17A feedback loop drives th17-mediated inflammation in behçet's uveitis. ADVS, 12(16), 2411524. (www)

  @article{ , abstract = {Behçet's uveitis (BU) is a severe ocular manifestation of Behçet's disease, typically accompanied by abnormal neutrophil infiltration and hyperactivation. However, the underlying causes of excessive neutrophil extracellular traps (NETs) production and mechanisms by which NETs contribute to the pathogenesis of BU remain incompletely understood. Neutrophils from BU patients exhibit a higher propensity for NETs release compared to healthy controls. In the experimental autoimmune uveitis (EAU), neutrophils are observed to exert pro-inflammatory effects through NETs. Clearing NETs can inhibit T helper 17 (Th17) cell differentiation and significantly alleviate EAU symptoms. In vivo and in vitro experiments demonstrate neutralizing IL-17A markedly reducing neutrophil infiltration and NETs formation in EAU. Single-cell RNA sequencing confirms that CD44 plays a key role in mediating interactions between NETs and Th17 cells. Antagonizing CD44 inhibits the proportion of Th17 cells and NETs formation. Multiplex immunofluorescence and cell communication analyses further demonstrate interactions and colocalization between NETs and CD44 high CD4 + T cells in EAU. NETs induce Th17 differentiation via upregulating CD44, and in turn, Th17 cells secrete IL-17A to recruit neutrophils and promote NETs formation. Interrupting NETs-CD44-IL-17A feedback loop may be a potential therapeutic target for BU.}, archive = {J_ADVS}, author = {Yi Wu and Kang Ning and Zhaohao Huang and Binyao Chen and Junjie Chen and Yingying Wen and Jian Bu and Han Hong and Qiaorong Chen and Zhuoqi Zhang and Renbing Jia and Wenru Su}, doi = {10.1002/advs.202411524}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2411524}, shortjournal = {Adv. Sci.}, title = {NETs-CD44-IL-17A feedback loop drives th17-mediated inflammation in behçet's uveitis}, volume = {12}, year = {2025}, }
• (2025). TRIM38 suppresses the progression of colorectal cancer via enhancing CCT6A ubiquitination to inhibit the MYC pathway. ADVS, 12(16), 2411285. (www)

  @article{ , abstract = {Emerging evidence reveals the pivotal function of tripartite motif protein (TRIM) in colorectal cancer (CRC). However, the precise function of TRIM38 and its underlying mechanism in CRC remains to be elucidated, especially regarding its putative ubiquitination function. Here, it is identified that TRIM38 is downregulated in CRC tissues by DNA hypermethylation of its promoter. Further analysis demonstrates that decreased TRIM38 is correlated with unfavorable clinical features and poor prognosis. Moreover, TRIM38 functions as a tumor suppressor by inhibiting cell proliferation, metastasis, and AOM/DSS-induced tumorigenesis in CRC cells. Mechanistically, TRIM38 binds to the substrate protein CCT6A, leading to the degradation and K48-linked ubiquitination of CCT6A at the K127/K138 residues. The elevation of CCT6A protein level caused by TRIM38 downregulation diminishes the degradation of c-Myc protein, thereby activating the MYC pathway. The study elucidates a novel mechanism of TRIM38/CCT6A/c-Myc axis regulating CRC, potentially offering a new therapeutic target for its treatment.}, archive = {J_ADVS}, author = {Yue Zhang and Xinyu Tan and Lu Wang and Dongjian Ji and Chuan Zhang and Wen Peng and Renzhong Zhu and Xiaowei Wang and Jiahui Zhou and Yifei Feng and Yueming Sun}, doi = {10.1002/advs.202411285}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2411285}, shortjournal = {Adv. Sci.}, title = {TRIM38 suppresses the progression of colorectal cancer via enhancing CCT6A ubiquitination to inhibit the MYC pathway}, volume = {12}, year = {2025}, }
• (2025). CK2B induces CD8+ T-cell exhaustion through HDAC8-mediated epigenetic reprogramming to limit the efficacy of anti-PD-1 therapy in non-small-cell lung cancer. ADVS, 12(16), 2411053. (www)

  @article{ , abstract = {Anti-PD-1 therapy has left an indelible mark in the field of non-small-cell lung cancer (NSCLC) treatment; however, its efficacy is limited in clinical practice owing to differences in the degree of effector T-cell exhaustion. Casein kinase 2 (CK2) is a protein kinase that plays an important role in T-cell immunity. In this study, it is aimed to explore the potential of targeting CK2 and its regulatory subunit CK2B to prevent or reverse T-cell exhaustion, thereby enhancing the efficacy of anti-PD-1 therapy in NSCLC. In this study, it is found that CK2B expression is closely associated with T-cell exhaustion as well as the efficacy of anti-PD-1 therapy based on scRNA-seq and in vitro and in vivo experiments. Utilization of CK2 inhibitors or knockdown of CK2B expression can upregulate TBX21 expression through HDAC8-mediated epigenetic reprogramming, restoring the effector function of CD8 + T cells and enhancing the efficacy of anti-PD-1 therapy in NSCLC. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8 + T cells, thereby enhancing the efficacy of anti-PD-1 and adoptive cell therapies in NSCLC. Moreover, CK2B expression serves as a novel predictor of immunotherapy efficacy for NSCLC.}, archive = {J_ADVS}, author = {Shaochuan Liu and Shiya Ma and Gen Liu and Lingjie Hou and Yong Guan and Liang Liu and Yuan Meng and Wenwen Yu and Ting Liu and Li Zhou and Zhiyong Yuan and Shuju Pang and Siyuan Zhang and Junyi Li and Xiubao Ren and Qian Sun}, doi = {10.1002/advs.202411053}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2411053}, shortjournal = {Adv. Sci.}, title = {CK2B induces CD8+ T-cell exhaustion through HDAC8-mediated epigenetic reprogramming to limit the efficacy of anti-PD-1 therapy in non-small-cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). RFWD3 reprograms nucleotide metabolism through PHGDH to induce chemoresistance in osteosarcoma. ADVS, 12(16), 2410937. (www)

  @article{ , abstract = {Chemoresistance represents a major challenge for osteosarcoma treatment. Despite the improved knowledge of cancer biology, the core determinants of cisplatin (DDP) resistance in osteosarcoma remain unclear and deserve further exploration. Here, RFWD3 is identified as a key regulator of DDP sensitivity in osteosarcoma using a genome-wide CRISPR screen. It is demonstrated that RFWD3 is overexpressed in post-chemotherapy osteosarcoma tissues compared to pre-chemotherapy tissues. Knocking out RFWD3 increased the sensitivity of osteosarcoma cells to DDP treatment. Mechanistically, RFWD3 bound to and ubiquitinated PHGDH at the Lys137 residue, promoting its degradation and conserving cellular oxidized nicotinamide adenine dinucleotide (NAD + ). The resulting surplus of NAD + enhanced the TCA cycle, leading to increased production of aspartic acid and glutamic acid for de novo nucleotide biosynthesis. In addition, virtual screening techniques are employed to identify Lomitapide as a specific inhibitor of the RFWD3-PHGDH interaction, capable of disrupting the binding between RFWD3 and PHGDH. It is found that Lomitapide exhibits a significant synergistic anti-osteosarcoma effect when combined with DDP. In conclusion, a specific role of RFWD3 in regulating nucleotide metabolism is revealed and comprised of targetable candidates for overcoming chemoresistance in osteosarcoma.}, archive = {J_ADVS}, author = {Wenchao Zhang and Chi Yin and Lin Qi and Zhongyue Liu and Ruiling Xu and Chao Tu and Zhihong Li}, doi = {10.1002/advs.202410937}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2410937}, shortjournal = {Adv. Sci.}, title = {RFWD3 reprograms nucleotide metabolism through PHGDH to induce chemoresistance in osteosarcoma}, volume = {12}, year = {2025}, }
• (2025). UniMap: Type-level integration enhances biological preservation and interpretability in single-cell annotation. ADVS, 12(16), 2410790. (www)

  @article{ , abstract = {Integrating single-cell datasets from multiple studies provides a cost-effective way to build comprehensive cell atlases, granting deeper insights into cellular characteristics across diverse biological systems. However, current data integration methods struggle with interference in partially overlapping datasets and varying annotation granularities. Here, a multiselective adversarial network is introduced for the first time and present UniMap, which functions as a “discerner” to identify and exclude interfering cells from various data sources during dataset integration. Compared to other state-of-the-art methods, UniMap emphasizes type-level integration and proves to be the best model for preserving biological variability, achieving noticeably higher accuracy in single-cell automated annotation under various circumstances. Additionally, it enhances interpretability by revealing shared and domain-specific cell types and providing prediction confidence. The efficacy of UniMap is demonstrated in terms of identifying new cell types, creating high-resolution cell atlases, annotating cells along developmental trajectories, and performing cross-species analysis, underscoring its potential as a robust tool for single-cell research.}, archive = {J_ADVS}, author = {Haitao Hu and Yue Guo and Fujing Ge and Hao Yin and Hao Zhang and Zhesheng Zhou and Fangjie Yan and Qing Ye and Jialu Wu and Ji Cao and Chang-Yu Hsieh and Bo Yang}, doi = {10.1002/advs.202410790}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2410790}, shortjournal = {Adv. Sci.}, title = {UniMap: Type-level integration enhances biological preservation and interpretability in single-cell annotation}, volume = {12}, year = {2025}, }
• (2025). Large-scale plasma proteomics to profile pathways and prognosis of chronic pain. ADVS, 12(16), 2410160. (www)

  @article{ , abstract = {While increasing peripheral mechanisms related to chronic pain, the plasma proteomics profile associated with it and its prognosis remains elusive. This study utilizes 2923 plasma proteins and chronic pain of 51 644 participants from UK Biobank and finds 474 proteins linked to chronic pain in six sites: head, neck or shoulder, back, stomach or abdominal, hip, and knee, with 11 proteins sharing across pain sites. The identified proteins are largely enriched in immune and metabolic pathways and highly expressed in tissues like lungs and small intestines. Phenome-wide analysis highlights the significance of pain-related proteome on diverse facets of human health, and in-depth Mendelian randomization validates 10 proteins (CD302, RARRES2, TNFRSF1B, BTN2A1, TNFRSF9, COL18A1, TNF, CD74, TNFRSF4, and BTN2A1) as markers of chronic pain. Furthermore, protein sets capable of classifying pain patients and healthy participants, particularly performing best in hip pain (area under curve, AUC = 0.725), are identified. Interestingly, the prediction of pain spreading over ten years achieves an AUC of 0.715, with leptin identified as a crucial predictor. This study delineates proteins associated with various pain conditions and identifies proteins capable of classifying pain and predicting pain spreading, offering benefits for both research and clinical practice.}, archive = {J_ADVS}, author = {Ze-Yu Li and Qing Ma and Jie Zhang and Rui-Ying Yin and Jia You and Qi-Zheng Hao and Xin-Rui Wu and Ju-Jiao Kang and Lin-Bo Wang and Yue-Ting Deng and Yu-Zhu Li and Chun Shen and Bang-Sheng Wu and Jian-Feng Feng and Yi-Heng Tu and Xiao Xiao and Jin-Tai Yu and Wei Cheng}, doi = {10.1002/advs.202410160}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2410160}, shortjournal = {Adv. Sci.}, title = {Large-scale plasma proteomics to profile pathways and prognosis of chronic pain}, volume = {12}, year = {2025}, }
• (2025). Pan-variant SARS-CoV-2 vaccines induce protective immunity by targeting conserved epitopes. ADVS, 12(16), 2409919. (www)

  @article{ , abstract = {The development of a globally effective COVID-19 vaccine faces significant challenges, particularly in redirecting the B-cell response from immunodominant yet variable regions of viral proteins toward their conserved domains. To address this, an integrated strategy is implemented that combines classical B-cell epitope prediction with protein-antibody cluster docking and antibody titer analysis from 30 vaccinated and convalescent individuals. This approach yields stable immunodominant and immunoprevalent B-cell epitopes capable of eliciting robust antibody responses in BALB/c mice and effectively neutralizing pseudoviruses expressing the Spike protein of SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, Delta, and Omicron. To achieve a broader T-cell-based immune response, promiscuous T-cell epitopes are identified by integrating classical T-cell epitope predictions, differential scanning fluorimetry, and peptide-MHC structural analysis. Unique peptides with conserved MHC-anchoring residues are identified, enabling binding to a spectrum of MHC-I and MHC-II haplotypes. These peptides elicit strong interferon gamma responses in human peripheral blood mononuclear cells and demonstrate cross-species efficacy by activating both CD4+ and CD8+ T-cells in BALB/c mice. Collectively, these findings highlight the significance of innovative vaccine strategies targeting immunodominant/immunoprevalent B-cell and promiscuous T-cell epitopes to drive broad and robust humoral and cellular immune responses against a wide range of SARS-CoV-2 variants.}, archive = {J_ADVS}, author = {Masaud Shah and Sung Ung Moon and Ji-Yon Shin and Ji-Hye Choi and Doyoon Kim and Hyun Goo Woo}, doi = {10.1002/advs.202409919}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2409919}, shortjournal = {Adv. Sci.}, title = {Pan-variant SARS-CoV-2 vaccines induce protective immunity by targeting conserved epitopes}, volume = {12}, year = {2025}, }
• (2025). ROS-responsive microneedle patches enable peri-lacrimal gland therapeutic administration for long-acting therapy of sjögren's syndrome-related dry eye. ADVS, 12(16), 2409562. (www)

  @article{ , abstract = {Sjögren's syndrome-related dry eye (SSDE) is a severe dry eye subtype characterized by significant immune cell attacks on the lacrimal gland. However, delivering immunosuppressive drugs to the lacrimal glands for SSDE therapy safely and sustainably poses significant challenges in clinical practice. Herein, a ROS-responsive microneedle patch with detachable functionality (CE-MN) is developed to enable straightforward and minimally invasive administration to the lacrimal gland area by penetrating the periocular skin. CE-MN is loaded with immunosuppressive cyclosporin A and anti-inflammatory drug epigallocatechin gallate, the latter also serving as a cross-linker for the microneedle matrix. Poly(N-isopropylacrylamide-co-butylacrylate), a temperature-sensitive polymer is utilized to fabricate separable layers that allow controlled detachment of the base from the needle, reducing patient discomfort. CE-MN is capable of modulating drug release by responding to ROS, facilitating on-demand release, and drug accumulation to the lacrimal gland. Compared to traditional eye drops, the CE-MN patch facilitated long-acting drug delivery to the lacrimal gland for more than 48 h, demonstrating potent anti-inflammatory and immunosuppressive effects in an SSDE mouse model by scavenging ROS and inhibiting the proliferation of Th1, Th17 cells, and macrophages. Overall, this long-acting microneedle patch potentially offers a novel clinical approach for treating SSDE and other ocular chronic diseases.}, archive = {J_ADVS}, author = {Jingqing Mu and Xiangyu Ding and Yapeng Song and Baoyue Mi and Xiaolong Fang and Baihua Chen and Bin Yao and Xuguang Sun and Xiaoyong Yuan and Shutao Guo and Xia Hua}, doi = {10.1002/advs.202409562}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2409562}, shortjournal = {Adv. Sci.}, title = {ROS-responsive microneedle patches enable peri-lacrimal gland therapeutic administration for long-acting therapy of sjögren's syndrome-related dry eye}, volume = {12}, year = {2025}, }
• (2025). Programmed fabrication of vesicle-based prototissue fibers with modular functionalities. ADVS, 12(16), 2409066. (www)

  @article{ , abstract = {Multicellular organisms have hierarchical structures where multiple cells collectively form tissues with complex 3D architectures and exhibit higher-order functions. Inspired by this, to date, multiple protocell models have been assembled to form tissue-like structures termed prototissues. Despite recent advances in this research area, the programmed assembly of protocells into prototissue fibers with emergent functions still represents a significant challenge. The possibility of assembling prototissue fibers will open up a way to a novel type of prototissue subunit capable of hierarchical assembly into unprecedented soft functional materials with tunable architectures, modular and distributed functionalities. Herein, the first method to fabricate freestanding vesicle-based prototissue fibers with controlled lengths and diameters is devised. Importantly, it is also shown that the fibers can be composed of different specialized modules that, for example, can endow the fiber with magnetotaxis capabilities, or that can work synergistically to take an input diffusible chemical signals and transduce it into a readable fluorescent output through a hosted enzyme cascade reaction. Overall, this research addresses an important challenge of prototissue engineering and will find important applications in 3D bio-printing, tissue engineering, and soft robotics as next-generation bioinspired materials.}, archive = {J_ADVS}, author = {Tomoya Kojima and Kouichi Asakura and Pierangelo Gobbo and Taisuke Banno}, doi = {10.1002/advs.202409066}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2409066}, shortjournal = {Adv. Sci.}, title = {Programmed fabrication of vesicle-based prototissue fibers with modular functionalities}, volume = {12}, year = {2025}, }
• (2025). Polyplex nanomicelle-mediated pgc-1α4 mRNA delivery via hydrodynamic limb vein injection enhances damage resistance in duchenne muscular dystrophy mice. ADVS, 12(16), 2409065. (www)

  @article{ , abstract = {Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, leading to the absence of dystrophin and progressive muscle degeneration. Current therapeutic strategies, such as exon-skipping and gene therapy, face limitations including truncated dystrophin production and safety concerns. To address these issues, a novel mRNA-based therapy is explored using polyplex nanomicelles to deliver mRNA encoding peroxisome proliferator-activated receptor gamma coactivator 1 alpha isoform 4 (PGC-1α4) via hydrodynamic limb vein (HLV) administration. Using an in vivo muscle torque measurement technique, it is observed that nanomicelle-delivered Pgc-1α4 mRNA significantly improved muscle damage resistance and mitochondrial activity in mdx mice. Specifically, HLV administration of Pgc-1α4 mRNA in dystrophic muscles significantly relieved the torque reduction and myofiber injury induced by eccentric contraction (ECC), boosted metabolic gene expression, and enhanced muscle oxidative capacity. In comparison, lipid nanoparticles (LNPs), a widely used mRNA delivery system, does not achieve similar protective effects, likely due to their intrinsic immunogenicity. This foundational proof-of-concept study highlights the potential of mRNA-based therapeutics for the treatment of neuromuscular diseases such as DMD and demonstrates the capability of polyplex nanomicelles as a safe and efficient mRNA delivery system for therapeutic applications.}, archive = {J_ADVS}, author = {Xuan Du and Hideyuki Nakanishi and Takashi Yamada and Yooksil Sin and Katsura Minegishi and Norio Motohashi and Yoshitsugu Aoki and Keiji Itaka}, doi = {10.1002/advs.202409065}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2409065}, shortjournal = {Adv. Sci.}, title = {Polyplex nanomicelle-mediated pgc-1α4 mRNA delivery via hydrodynamic limb vein injection enhances damage resistance in duchenne muscular dystrophy mice}, volume = {12}, year = {2025}, }
• (2025). MaTableGPT: GPT-based table data extractor from materials science literature. ADVS, 12(16), 2408221. (www)

  @article{ , abstract = {Efficiently extracting data from tables in the scientific literature is pivotal for building large-scale databases. However, the tables reported in materials science papers exist in highly diverse forms; thus, rule-based extractions are an ineffective approach. To overcome this challenge, the study presents MaTableGPT, which is a GPT-based table data extractor from the materials science literature. MaTableGPT features key strategies of table data representation and table splitting for better GPT comprehension and filtering hallucinated information through follow-up questions. When applied to a vast volume of water splitting catalysis literature, MaTableGPT achieves an extraction accuracy (total F1 score) of up to 96.8%. Through comprehensive evaluations of the GPT usage cost, labeling cost, and extraction accuracy for the learning methods of zero-shot, few-shot, and fine-tuning, the study presents a Pareto-front mapping where the few-shot learning method is found to be the most balanced solution owing to both its high extraction accuracy (total F1 score >95%) and low cost (GPT usage cost of 5.97 US dollars and labeling cost of 10 I/O paired examples). The statistical analyses conducted on the database generated by MaTableGPT revealed valuable insights into the distribution of the overpotential and elemental utilization across the reported catalysts in the water splitting literature.}, archive = {J_ADVS}, author = {Gyeong Hoon Yi and Jiwoo Choi and Hyeongyun Song and Olivia Miano and Jaewoong Choi and Kihoon Bang and Byungju Lee and Seok Su Sohn and David Buttler and Anna Hiszpanski and Sang Soo Han and Donghun Kim}, doi = {10.1002/advs.202408221}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2408221}, shortjournal = {Adv. Sci.}, title = {MaTableGPT: GPT-based table data extractor from materials science literature}, volume = {12}, year = {2025}, }
• (2025). Functional polarization of liver macrophages by glyco gold nanoparticles. ADVS, 12(16), 2407458. (www)

  @article{ , abstract = {Macrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer-promoting activity or trigger anti-inflammatory immunity. Glycans have emerged as key components for immunity as they are involved in many pathophysiological disorders. Previous studies have demonstrated that supraphysiological amounts of mannose (Man) or sialic acid (Sia) can inhibit tumor growth and stimulate differentiation of regulatory T cells. Man is known to affect glucose metabolism in glycolysis by competing for the same intracellular transporters and affecting macrophage polarization, whereas Sia alters macrophage differentiation via signaling through Siglec-1. Herein, this work describes a macrophage targeting platform using gold nanoparticles (GNPs) functionalized with Man and Sia monosaccharides which exhibit high liver tropism. A single dose of glyco-GNPs can convert macrophages to a restorative phenotype in two completely different immune environments. Man promotes tumor-associated macrophages toward an antitumorigenic activity in a MC38 liver colorectal cancer model by secretion of TNF-α, IL -1β, and IL -6 in the tumor microenvironment. However, in a proinflammatory environment, as observed in a mouse model of autoimmune disease, primary biliary cholangitis, Man impairs the production of TNF-α, IL-1β, Arg1, and IL-6 cytokines. The results probe the dual role of Man in macrophage repolarization in response to the immune system. This study is a proof-of-concept that demonstrates that nanomedicine using specific glycans designed to target other immune cells such as myeloid cells, are a promising strategy not only against cancer but also against other pathologies such as autoimmune diseases.}, archive = {J_ADVS}, author = {Jennifer Fernandez Alarcon and Patricia Perez Schmidt and Nicolo Panini and Francesca Caruso and Martina B. Violatto and Naths Grazia Sukubo and Alberto Martinez-Serra and Charlotte Blanche Ekalle-Soppo and Annalisa Morelli and Giulia Yuri Moscatiello and Chiara Grasselli and Alessandro Corbelli and Fabio Fiordaliso and Joe Kelk and Laura Petrosilli and Giuseppe d'Orazio and Ruth Mateu Ferrando and Ariadna Verdaguer Ferrer and Cristina Fornaguera and Luigi Lay and Stefano Fumagalli and Sandro Recchia and Marco P. Monopoli and Laura Polito and Paolo Bigini and Giovanni Sitia}, doi = {10.1002/advs.202407458}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2407458}, shortjournal = {Adv. Sci.}, title = {Functional polarization of liver macrophages by glyco gold nanoparticles}, volume = {12}, year = {2025}, }
• (2025). Structural insights into an antiparallel chair-type G-quadruplex from the intron of NOP56 oncogene. ADVS, 12(16), 2406230. (www)

  @article{ , abstract = {G-quadruplex (G4) structures play important roles in various biological processes, especially the gene regulation. Nucleolar protein 56 (NOP56) is an essential component in ribosome biogenesis while its overexpression associates with various types of cancers, rendering it a significant therapeutic target. Here for the first time, an antiparallel chair-type G4 structure formed by a 21-nt DNA sequence from the intron 1 of NOP56 is reported, and its high-resolution structure is determined using solution nuclear magnetic resonance spectroscopy. The NOP56 -G4 has a special fold containing two G-tetrads and a C·G·C·G tetrad, which is further capped by a C∙C base pair. The G4 ligand pyridostatin (PDS) binds at the terminal G-tetrad through π–π stacking and electrostatic interactions, increasing the melting temperature of NOP56 -G4 by ≈14 °C. This study further shows that PDS can significantly reduce NOP56 mRNA levels in three cancer cell lines. This work provides an unprecedented high-resolution structural basis for a special G4 structure from the intron of NOP56 and suggests a feasibility of targeting intronic G4 for gene regulation, propelling new avenues for G4 structure-based drug design and therapeutic strategy.}, archive = {J_ADVS}, author = {Zhenzhen Yan and Axin He and Liqi Wan and Qian Gao and Yan Jiang and Yang Wang and Ercheng Wang and Changling Li and Yingquan Yang and Yingjie Li and Pei Guo and Da Han}, doi = {10.1002/advs.202406230}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2406230}, shortjournal = {Adv. Sci.}, title = {Structural insights into an antiparallel chair-type G-quadruplex from the intron of NOP56 oncogene}, volume = {12}, year = {2025}, }
• (2025). Sensory encoding alternates with hippocampal ripples across cycles of forebrain spiking cascades. ADVS, 12(16), 2406224. (www)

  @article{ , abstract = {The brain's response to external events depends on its internal arousal states, which are dynamically governed by neuromodulatory systems and have recently been linked to coordinated spike timing cascades in widespread brain networks. At rest, both arousal fluctuations and spiking cascades are evident throughout the forebrain and play out over multisecond time scales. Here, by analyzing large-scale neural recording data collected by the Allen Institute, it is demonstrated that these intrinsic processes persist across the mouse brain even during periods of continuous visual stimulation. In the stationary animal, each quasi-periodic cascade cycle systematically influenced 1) the efficacy of encoding in visually responsive brain areas and 2) the incidence of memory-related hippocampal ripples. During this cycle, the phase of high arousal is marked by high efficiency in visual encoding whereas the phase of low arousal is marked by the occurrence of hippocampal ripples. However, during bouts of active locomotion, this cycle is abolished and brain maintained a state of elevated visual coding efficiency, with ripples being nearly absent. It is hypothesized that the infra-slow cascade dynamics reflect an adaptive cycle of alternating exteroceptive sensory sampling and internal mnemonic function that persistently pervades the forebrain, only stopping during active exploration of the environment.}, archive = {J_ADVS}, author = {Yifan Yang and David A. Leopold and Jeff H. Duyn and Grayson O. Sipe and Xiao Liu}, doi = {10.1002/advs.202406224}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2406224}, shortjournal = {Adv. Sci.}, title = {Sensory encoding alternates with hippocampal ripples across cycles of forebrain spiking cascades}, volume = {12}, year = {2025}, }
• (2025). Transformation of 3D Metal–Organic frameworks into nanosheets with enhanced memristive behavior for electronic data processing. ADVS, 12(16), 2405989. (www)

  @article{ , abstract = {The transition from three-dimensional (3D) to two-dimensional (2D) semiconducting and insulating materials for micro- and opto-electronics is driven by an energy efficiency and device miniaturization. Herein, the simplicity of growth and stacking of 2D metal–organic framework (MOF) with such planar devices opens up new perspectives in controlling their efficiency and operating parameters. Here, the study reports on 3D to 2D MOF’ structural transformation to achieve ultrathin nanosheets with enhanced insulating properties. Based on neutral N-donor ligands, the study designs and solvothermally synthesizes 3D MOFs followed by their thermal and solvent treatment to implement the transformation. A set of single crystal and powder X-ray diffraction, electron microscopy, Raman spectroscopy, numerical modeling, and mechanical exfoliation confirm the nature of the transformation. Compared with initial 3D MOF, its nanosheets demonstrate sufficient changes in electronic properties, expressed as tuning their absorption, photoluminescence, and resistivity. The latter allows to demonstrate the prototype of ultrathin memristive element based on a 4 to 32 nm MOF nanosheet with enhanced functionality (150 to 1400 ON/OFF ratio, retention time exceeding 7300 s, and 100 cycles of switching), thereby, extending the list of scalable and insulating 2D MOFs for micro- and opto-electronics.}, archive = {J_ADVS}, author = {Yuri A. Mezenov and Semyon V. Bachinin and Yuliya A. Kenzhebayeva and Anastasiia S. Efimova and Pavel V. Alekseevskiy and Daria Poloneeva and Anastasia Lubimova and Svyatoslav A. Povarov and Vladimir Shirobokov and Mikhail S. Dunaevskiy and Aleksandra S. Falchevskaya and Andrei S. Potapov and Alexander Novikov and Artem A. Selyutin and Pascal Boulet and Alena N. Kulakova and Valentin A. Milichko}, doi = {10.1002/advs.202405989}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2405989}, shortjournal = {Adv. Sci.}, title = {Transformation of 3D Metal–Organic frameworks into nanosheets with enhanced memristive behavior for electronic data processing}, volume = {12}, year = {2025}, }
• (2025). Interpretable machine-learning and big data mining to predict the CO2 separation in polymer-MOF mixed matrix membranes. ADVS, 12(16), 2405905. (www)

  @article{ , abstract = {Mixed matrix membranes (MMMs) are renowned for their exceptional gas separation capabilities. In this work, high-throughput computing screening and machine learning are employed to evaluate the CO 2 separation performance of 54117 MMMs composed of 9 polymers and 6013 metal–organic frameworks (MOFs). The structure-property relationships of MMMs are analyzed for 4 binary mixtures (CO 2 /X, X = CH 4 , N 2 , H 2 , O 2 ), and the best-performing combinations of MOFs and polymers are found, with which the MMM performance exceeded the Robeson's upper limit. Then, a stacked ensemble regression model with high accuracy (average R 2 = 0.96) is trained, demonstrating excellent extrapolation capability ( R 2 = 0.95) for new MMMs containing 6FDA-DAM. Furthermore, by utilizing Shapley Additive Explanations and data segmentation, it is identified that the pore limit diameter and largest cavity diameter in MOF features and the fractional free volume and density in polymer features are of paramount importance. Two extrapolation methods are compared and found that transfer learning is better for predicting CO 2 separation performance in MMMs and designing new materials with large datasets. Finally, an interactive desktop software is developed to assist researchers in rapidly and accurately calculating the CO 2 separation performance of MMMs. This work presents a novel approach for the rapid evaluation of high-quality MMMs and the efficient calculation of gas permeation rates within membranes.}, archive = {J_ADVS}, author = {Hao Wan and Yue Fang and Min Hu and Shuya Guo and Zhiqiang Sui and Xiaoshan Huang and Zili Liu and Yue Zhao and Hong Liang and Yufang Wu and Hanyu Gao and Zhiwei Qiao}, doi = {10.1002/advs.202405905}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2405905}, shortjournal = {Adv. Sci.}, title = {Interpretable machine-learning and big data mining to predict the CO2 separation in polymer-MOF mixed matrix membranes}, volume = {12}, year = {2025}, }
• (2025). Roles of kdm6a and kdm6b in regulation of mammalian neural regeneration. ADVS, 12(16), 2405537. (www)

  @article{ , abstract = {Epigenetic regulation of neuronal transcriptomic landscape is emerging to be a key coordinator of mammalian neural regeneration. The roles of two histone 3 lysine 27 (H3K27) demethylases, Kdm6a/b, in controlling neuroprotection and axon regeneration are investigated here. Deleting either Kdm6a or Kdm6b leads to enhanced sensory axon regeneration in the peripheral nervous system (PNS), whereas in the central nervous system (CNS), only deleting Kdm6a in retinal ganglion cells (RGCs) significantly enhances optic nerve regeneration. Moreover, both Kdm6a and Kdm6b function to regulate RGC survival but with different mechanisms. Mechanistically, Kdm6a regulates RGC regeneration via distinct pathway from that of Pten, and co-deleting Kdm6a and Pten results in long distance optic nerve regeneration passing the optic chiasm. In addition, RNA-seq profiling reveals that Kdm6a deletion switches the RGC transcriptomics into a developmental-like state and suppresses several known repressors of neural regeneration. Klf4 is identified as a direct downstream target of Kdm6a-H3K27me3 signaling in both sensory neurons and RGCs to regulate axon regeneration. These findings not only reveal different roles of Kdm6a and Kdm6b in regulation of neural regeneration and their underlying mechanisms, but also identify Kdm6a-mediated histone demethylation signaling as a novel epigenetic target for supporting CNS neural regeneration.}, archive = {J_ADVS}, author = {Shu-Guang Yang and Chang-Ping Li and Xue-Wei Wang and Tao Huang and Cheng Qian and Qiao Li and Ling-Rui Zhao and Si-Yu Zhou and Chen-Yun Ding and Rui Nie and Saijilafu and Yu-Cai Hong and Chang-Mei Liu and Feng-Quan Zhou}, doi = {10.1002/advs.202405537}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2405537}, shortjournal = {Adv. Sci.}, title = {Roles of kdm6a and kdm6b in regulation of mammalian neural regeneration}, volume = {12}, year = {2025}, }
• (2025). Blockade of ZMIZ1-GATA4 axis regulation restores youthfulness to aged cartilage. ADVS, 12(16), 2404311. (www)

  @article{ , abstract = {Susceptibility to cartilage degeneration increases in an age-dependent manner and older cartilage exhibits increased catabolic factor expression leading to osteoarthritis (OA). While inhibition of cellular senescence can prevent age-related diseases, the understanding of the regulators governing cartilage senescence and the potential for senolytic intervention remains limited. Here, in vitro and in vivo results are reported, demonstrating for the first time that the transcriptional regulator, ZMIZ1, is upregulated in aged and OA cartilage, and that it acts through GATA4 to accelerate chondrocyte senescence and trigger cartilage deterioration. Furthermore, it is shown that K-7174 interferes with the ZMIZ1-GATA4 interaction and effectively hampers cartilage senescence and OA. It is proposed that inhibition of the ZMIZ1-GATA4 axis could be a valuable strategy for eliminating senescent chondrocytes and impeding OA development and that the relevant inhibitor, K-7174, could potentially be developed as a senolytic drug for managing cartilage senescence and age-related degeneration.}, archive = {J_ADVS}, author = {Jiho Nam and Hyunmin Woo and Jihye Yang and Seok Jung Kim and Kwang Pyo Lee and Ji Hoon Yu and Tae Joo Park and Seong-il Eyun and Siyoung Yang}, doi = {10.1002/advs.202404311}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2404311}, shortjournal = {Adv. Sci.}, title = {Blockade of ZMIZ1-GATA4 axis regulation restores youthfulness to aged cartilage}, volume = {12}, year = {2025}, }
• (2025). 3D printed low-tortuosity and ultra-thick hierarchical porous electrodes for high-performance wearable quasi-solid-state zn-VOH batteries. ADVS, 12(16), 2401660. (www)

  @article{ , abstract = {Rechargeable aqueous Zn-ion batteries have received considerable attention in energy storage systems owing to their merits of high safety, low cost, and excellent rate performance. However, the unsatisfactory areal energy density and poor cycling performance hinder their practical applications. Herein, the V 5 O 12 ·6H 2 O (VOH) nanosheet arrays and Zn nanoflake arrays growing on the 3D-printed reduced graphene oxide/carbon nanotubes (3DP-rGO/CNTs) microlattices employing the electrodeposition technique, and further serve as the cathode and anode for 3D-printed aqueous Zn-VOH battery, respectively. Benefiting from 3D-printed low-tortuosity and ultra-thick hierarchical porous electrodes, the battery-type VOH-based cathode enables fast Zn 2+ reaction kinetics and electrodeposited Zn-based anode delivers highly reversible Zn stripping/plating. The button-type 3D-printed aqueous Zn-VOH battery exhibits excellent energy/power densities (364.5 Wh kg −1 at 700 W kg −1 ) and remarkable cycling performance over 6500 cycles. Impressively, a customizable 3D-printed quasi-solid-state Zn-VOH battery device is fabricated, which presents ultrahigh areal capacity (≈17.06 mAh cm −2 at 0.2 mA cm −2 ), long-term durability (≈85.6% capacity retention after 10 000 cycles), and excellent wearable characters. This work provides a novel strategy to gain high-performance Zn-ion batteries based on 3D-printed electrodes, which may pave a new way for the applications of various high-performance, low-cost, and portable integrated energy storage systems.}, archive = {J_ADVS}, author = {Qingguo Xu and Ningning Chu and Ye Wang and Hui Wang and Tingting Xu and Xueliang Li and Shaozhuan Huang and Xinjian Li and Yongsong Luo and Hui Ying Yang and Dezhi Kong}, doi = {10.1002/advs.202401660}, journal = {Advanced Science}, month = {4}, number = {16}, pages = {2401660}, shortjournal = {Adv. Sci.}, title = {3D printed low-tortuosity and ultra-thick hierarchical porous electrodes for high-performance wearable quasi-solid-state zn-VOH batteries}, volume = {12}, year = {2025}, }
• (2025). LIMA1 O-GlcNAcylation promotes hepatic lipid deposition through inducing β-catenin-regulated FASn expression in metabolic dysfunction-associated steatotic liver disease (Adv. sci. 15/2025). ADVS, 12(15), 2570110. (www)

  @article{ , archive = {J_ADVS}, author = {Fuji Yang and Yifei Chen and Guojun Zheng and Kefeng Gu and Lin Fan and Tingfen Li and Ling Zhu and Yongmin Yan}, doi = {10.1002/advs.202570110}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570110}, shortjournal = {Adv. Sci.}, title = {LIMA1 O-GlcNAcylation promotes hepatic lipid deposition through inducing β-catenin-regulated FASn expression in metabolic dysfunction-associated steatotic liver disease (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). Squamocin suppresses tumor growth through triggering an endoplasmic reticulum stress-associated degradation of EZH2/MYC axis (Adv. sci. 15/2025). ADVS, 12(15), 2570109. (www)

  @article{ , archive = {J_ADVS}, author = {Yin Zhu and Yurui Liu and Xiangtao Wang and Zhifeng Chen and Baojian Chen and Bingxin Hu and Tiane Tang and Haoran Cheng and Xinglong Liu and Yunshan Ning}, doi = {10.1002/advs.202570109}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570109}, shortjournal = {Adv. Sci.}, title = {Squamocin suppresses tumor growth through triggering an endoplasmic reticulum stress-associated degradation of EZH2/MYC axis (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). The placenta regulates intrauterine fetal growth via exosomal PPARγ (Adv. sci. 15/2025). ADVS, 12(15), 2570108. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaofang Luo and Biao Huang and Ping Xu and Hao Wang and Baozhen Zhang and Li Lin and Jiujiang Liao and Mingyu Hu and Xiyao Liu and Jiayu Huang and Yong Fu and Mark D. Kilby and Rodney E. Kellems and Xiujun Fan and Yang Xia and Philip N. Baker and Hongbo Qi and Chao Tong}, doi = {10.1002/advs.202570108}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570108}, shortjournal = {Adv. Sci.}, title = {The placenta regulates intrauterine fetal growth via exosomal PPARγ (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). Curcumin modulates PTPRZ1 activity and RNA m6A modifications in neuroinflammation-associated microglial response (Adv. sci. 15/2025). ADVS, 12(15), 2570107. (www)

  @article{ , archive = {J_ADVS}, author = {Ninan Zhang and Ruifan Lin and Wenya Gao and Honglin Xu and Yuejia Li and Xiahe Huang and Yingchun Wang and Xianghong Jing and Wenxiang Meng and Qi Xie}, doi = {10.1002/advs.202570107}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570107}, shortjournal = {Adv. Sci.}, title = {Curcumin modulates PTPRZ1 activity and RNA m6A modifications in neuroinflammation-associated microglial response (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). Fabrication of graphene polyhedra: Unveiling new structures, forms, and properties (Adv. sci. 15/2025). ADVS, 12(15), 2570106. (www)

  @article{ , archive = {J_ADVS}, author = {Joong Yeon Lim and Seonghwan Kim and Muhammad Toyabur Rahman and Young-Seong Kim}, doi = {10.1002/advs.202570106}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570106}, shortjournal = {Adv. Sci.}, title = {Fabrication of graphene polyhedra: Unveiling new structures, forms, and properties (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). Bimodal in situ analyzer for circular RNA in extracellular vesicles combined with machine learning for accurate gastric cancer detection (Adv. sci. 15/2025). ADVS, 12(15), 2570104. (www)

  @article{ , archive = {J_ADVS}, author = {Yuhang Guo and Shihua Luo and Sinian Liu and Chao Yang and Weifeng Lv and Yuxin Liang and Tingting Ji and Wenbin Li and Chunchen Liu and Xin Li and Lei Zheng and Ye Zhang}, doi = {10.1002/advs.202570104}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570104}, shortjournal = {Adv. Sci.}, title = {Bimodal in situ analyzer for circular RNA in extracellular vesicles combined with machine learning for accurate gastric cancer detection (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). Gaseous synergistic self-assembly and arraying to develop bio-organic photocapacitors for neural photostimulation (Adv. sci. 15/2025). ADVS, 12(15), 2570103. (www)

  @article{ , archive = {J_ADVS}, author = {Xinyuan Fan and Yiming Tang and Jiahao Zhang and Kang Ma and Zhengyu Xu and Yuying Liu and Bin Xue and Yi Cao and Deqing Mei and Wei Wang and Guanghong Wei and Kai Tao}, doi = {10.1002/advs.202570103}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570103}, shortjournal = {Adv. Sci.}, title = {Gaseous synergistic self-assembly and arraying to develop bio-organic photocapacitors for neural photostimulation (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). Self-adaptive quantum kernel principal component analysis for compact readout of chemiresistive sensor arrays (Adv. sci. 15/2025). ADVS, 12(15), 2570102. (www)

  @article{ , archive = {J_ADVS}, author = {Zeheng Wang and Timothy van der Laan and Muhammad Usman}, doi = {10.1002/advs.202570102}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570102}, shortjournal = {Adv. Sci.}, title = {Self-adaptive quantum kernel principal component analysis for compact readout of chemiresistive sensor arrays (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). Oral microalgae-based biosystem to enhance irreversible electroporation immunotherapy in hepatocellular carcinoma (Adv. sci. 15/2025). ADVS, 12(15), 2570101. (www)

  @article{ , archive = {J_ADVS}, author = {Cheng Zeng and Shiyuan Hua and Jiayu Zhou and Tangye Zeng and Jianke Chen and Lijian Su and Angfeng Jiang and Min Zhou and Zhe Tang}, doi = {10.1002/advs.202570101}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2570101}, shortjournal = {Adv. Sci.}, title = {Oral microalgae-based biosystem to enhance irreversible electroporation immunotherapy in hepatocellular carcinoma (Adv. sci. 15/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “Large spin hall efficiency and current-induced magnetization switching in ferromagnetic heusler alloy Co2MnAl-based magnetic trilayers”. ADVS, 12(15), 2504185. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202504185}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2504185}, shortjournal = {Adv. Sci.}, title = {Correction to “Large spin hall efficiency and current-induced magnetization switching in ferromagnetic heusler alloy Co2MnAl-based magnetic trilayers”}, volume = {12}, year = {2025}, }
• (2025). Semi-organic artificial photosynthetic system with engineered phenoxazinone derivatives for photocatalytic hydrogen production with broadened near-infrared light harvesting. ADVS, 12(15), 2501037. (www)

  @article{ , abstract = {Natural photosynthetic systems utilize complex pigment-protein assemblies for light harvesting across a broad spectral range from UV to near-infrared, enabling efficient photogeneration and charge separation. Conventional photocatalysts, however, primarily absorb UV (<380 nm) and visible light (380–780 nm), resulting in suboptimal spectral utilization. This study introduces a semi-organic artificial photosynthetic system that integrates molecularly engineered phenoxazinone derivatives with H-doped rutile TiO 2 (H-TiO 2 ) nanorods. Bis(Triphenylamine)Phenoxazinone (BTP) features a phenoxazinone core with two triphenylamine donor groups, enabling light absorption up to 800 nm. Modifying BTP with an additional malononitrile group (MBTP) extends absorption into the NIR region up to 1200 nm. Optimized semi-organic catalysts with MBTP nanobelts and H-TiO 2 nanorods showed an excellent photocatalytic hydrogen evolution rate of 29.4 mmol g −1 h −1 and 60.4 µmol g −1 h −1 under UV–vis and NIR irradiation, respectively. Femtosecond transient absorption (fs-TA) spectroscopy showed rapid electron injection from the photoexcited phenoxazinone derivatives to the H-TiO 2 conduction band, indicating efficient charge carrier dynamics. Photoelectrochemical measurements confirmed improved charge transport and reduced recombination in the MBTP-based system, attributed to the stronger internal electric field and increased dipole moment from the malononitrile modification. These findings highlight the potential of tailored semi-organic systems for high-efficiency solar-to-hydrogen conversion.}, archive = {J_ADVS}, author = {Xiaowen Ruan and Depeng Meng and Minghua Xu and Guozhen Fang and Chunsheng Ding and Jing Leng and Xuan Wang and Kaikai Ba and Haiyan Zhang and Wei Zhang and Tengfeng Xie and Zhifeng Jiang and Jianan Dai and Xiaoqiang Cui and Sai Kishore Ravi}, doi = {10.1002/advs.202501037}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2501037}, shortjournal = {Adv. Sci.}, title = {Semi-organic artificial photosynthetic system with engineered phenoxazinone derivatives for photocatalytic hydrogen production with broadened near-infrared light harvesting}, volume = {12}, year = {2025}, }
• (2025). Molecular engineering strategies for organic pre-sodiation: Progress and challenges. ADVS, 12(15), 2500906. (www)

  @article{ , abstract = {Pre-sodiation, which is capable of supplying additional active sodium sources to sodium-ion batteries (SIBs), has been widely accepted as one of the most promising approaches to address the issue of active sodium loss during initial charging and subsequent cycling. Organic materials, with their design flexibility and abundant sources, are well-suited for large-scale applications. To achieve effective organic pre-sodiation, precise control over reaction potential is essential. In view of this, molecular engineering strategies are developed to mediate the pre-sodiation potential of organic materials for efficient pre-sodiation. Nevertheless, a comprehensive review of molecular engineering in organic pre-sodiation is still lacking. This timely review aims to present the crucial role of molecular engineering in organic pre-sodiation and provide an up-to-date overview of this field. After the showcasing of fundamental details of molecular engineering in organic pre-sodiation, recent advances in modifying oxidation decomposition/reduction potentials of organic pre-sodiation materials are briefly introduced, with a focus on the structure-activity relationship between functional group modifications and pre-sodiation potential. Future challenges and directions for developing next-generation organic pre-sodiation technologies are also reviewed. The current review provides important insights into molecular engineering in organic pre-sodiation, guiding the development of next-generation technologies of SIBs.}, archive = {J_ADVS}, author = {Zhijian Cai and Huai Chen and Fujun Niu}, doi = {10.1002/advs.202500906}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2500906}, shortjournal = {Adv. Sci.}, title = {Molecular engineering strategies for organic pre-sodiation: Progress and challenges}, volume = {12}, year = {2025}, }
• (2025). A versatile protein scaffold engineered for the hierarchical assembly of robust and highly active enzymes. ADVS, 12(15), 2500405. (www)

  @article{ , abstract = {Scaffold proteins play immense roles in bringing enzymes together to enhance their properties. However, the direct fusion of scaffold with bulky guest enzymes may disrupt the assembly process or diminish catalytic efficiency. Most self-assembling protein scaffolds are engineered to form structures beforehand, and then carry guest proteins via different conjugation strategies in vitro. Here, a robust self-assembling scaffold is presented, engineered from Methanococcus jannaschii using disulfide bonds, which efficiently assembles bulky enzymes into higher-order helices without additional chemistry or bio-conjugation in vitro. When fused directly with monomeric Endo-1,4-beta-xylanase A, the catalytic efficiency of the guest enzyme increased by 2.5 times with enhanced thermostability. Additionally, integrating the scaffold with the multimeric metalloenzyme nitrile hydratase overcame the typical stability-activity trade-off of such industrial enzyme, yielding three-fold higher activity and 28-fold higher thermostability. Structural analyses suggest that the artificially made helical twist structures create new interface interactions and provide a concentration of active sites of guest enzymes. Further fusion of fluorescent protein pairs with the scaffold exhibited a 12-fold higher FRET efficiency, suggesting its potential for dual-enzyme cascade applications. Overall, this study showcases a simple yet powerful protein scaffold that organizes guest enzymes into hierarchical structures with enhanced catalytic performance.}, archive = {J_ADVS}, author = {Yiwei Meng and Lukasz Peplowski and Tong Wu and Heng Gong and Ran Gu and Laichuang Han and Yuanyuan Xia and Zhongmei Liu and Zhemin Zhou and Zhongyi Cheng}, doi = {10.1002/advs.202500405}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2500405}, shortjournal = {Adv. Sci.}, title = {A versatile protein scaffold engineered for the hierarchical assembly of robust and highly active enzymes}, volume = {12}, year = {2025}, }
• (2025). Modifying microenvironment in van der waals gap by Cu/N co-doping strategy for highly efficient nitrite reduction to ammonia. ADVS, 12(15), 2417773. (www)

  @article{ , abstract = {Electroreduction of nitrite to ammonia has significant promise for economical NH 3 electrosynthesis and wastewater treatment. Herein, sulfur vacancies rich Cu─N co-doped SnS 2 nanosheet is designed as a highly active and durable NO 2 RR catalyst. Benefiting from the Cu─N co-doped strategy, Cu/N-SnS 2-x achieves the highest NH 3 yield rate of 18.15mg h −1 mg cat −1 at −0.935 V (vs RHE) and excellent Faradaic Efficiency of 95.73% at −0.835 V (vs RHE). In situ FT-IR and in situ XPS proves that Cu/N-SnS 2-x has a greater capacity for atomic hydrogen generation, which facilitates the conversion of nitrite to ammonia and maintains excellent structural stability during the NO 2 RR process. Theoretical calculations reveal that the introduced sulfur vacancies effectively expose the metal atoms inside SnS 2 and make them adsorb nitrite efficiently, which effectively accelerates the transformation of nitrite to ammonia. Besides, the introduced Cu and N can form a new electronic structure, which induces Cu in an electron-deficient state promotes the adsorption of reaction intermediates on Cu, and reduces the reaction energy barrier for nitrite reduction on the Cu/N-SnS 2-x surface. The current exploration presents fresh prospects for the rational development of an effective electrocatalyst for synthesizing ammonia from nitrite.}, archive = {J_ADVS}, author = {Heen Li and Yuanzhe Wang and Kuo Wei and Maoyue He and Mengmeng Yan and Fei Peng and Faming Gao}, doi = {10.1002/advs.202417773}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2417773}, shortjournal = {Adv. Sci.}, title = {Modifying microenvironment in van der waals gap by Cu/N co-doping strategy for highly efficient nitrite reduction to ammonia}, volume = {12}, year = {2025}, }
• (2025). Enhanced photoredox activity in nitrogen-doped carbon nitride for heterogeneous nitrogen and oxygen radical reactions. ADVS, 12(15), 2417752. (www)

  @article{ , abstract = {A nitrogen-doped carbon nitride (NCN) has been synthesized and utilized for the sustainable generation of reactive nitrogen and oxygen radicals under mild photocatalytic conditions. This material exhibits a significant improvement in the separation and transfer of photoexcited charge carriers, which facilitates the direct activation of N─H and O─H bonds to achieve a variety of radical carboamination, oxyamination and deoxygenation reactions. The NCN catalyst has further demonstrated its robust photoredox activity through several successful applications, including the aerobic oxidation of boronic acids and the controllable oxidation of alcohols to aldehydes and carboxylic acids. Moreover, the NCN catalyst maintains its reactivity and efficiency even after multiple cycles of use, showcasing its durability and potential for practical applications in sustainable chemistry.}, archive = {J_ADVS}, author = {Lan Qin and Huan Liu and Yi Wei and Lian-Qing Chen and Xiao-Qiang Hu}, doi = {10.1002/advs.202417752}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2417752}, shortjournal = {Adv. Sci.}, title = {Enhanced photoredox activity in nitrogen-doped carbon nitride for heterogeneous nitrogen and oxygen radical reactions}, volume = {12}, year = {2025}, }
• (2025). Mechanochemical-triggered confined coordination of iron-biomass composites for efficient Cr(VI) reduction under circumneutral pH via accelerated electron extraction. ADVS, 12(15), 2417368. (www)

  @article{ , abstract = {Green and eco-friendly iron-based materials for efficient Cr(VI) removal have attracted considerable interest, but challenges related to narrow working pH ranges and iron utilization efficiency still remain. Herein, inspired by the hot-spot effect-triggered confined coordination strategy, a biomass-confined iron-based reductant (CMC-GTB/Fe bm ) is designed for Cr(VI) reduction and detoxification. Electron enrichment and confinement on biomass carriers are achieved through electron transfer mediated by coordination interactions between anchored iron species and biomass. Thus, the CMC-GTB/Fe bm achieved 99% Cr(VI) reduction at circumneutral pH (5–9), with a maximum removal capacity of 180 mg g −1 . Under iron dosing close to the stoichiometric ratio (Fe/Cr = 3/1), the Cr(VI) removal kinetics and efficiency of CMC-GTB/Fe bm are 53.2–870.5 and 5.5–48.8 times higher than those of micro- or nano-zero-valent iron (ZVI), respectively. Mechanistic analyses revealed that confined electron transfer is facilitated by coordination interactions between biomass and anchored iron species, which enhanced Cr(VI) reduction. Moreover, biomass-tethered reduced Cr(III) is stabilized by electrostatic adsorption and biomass-Cr(III) coordination, which ultimately detoxifies the phytotoxicity of Cr(VI). The conversion of this strategy to kilogram-scale production and the simulated Cr(VI) removal in real water matrices are confirmed. This study provides a basis for the controlled design and industrial application of environmentally friendly iron-based reductants.}, archive = {J_ADVS}, author = {Yue Wang and Hongyu Li and Hao Liu and Chengsi Hou and Zhengwei Zhou and Shuai Peng and Zuofeng Chen and Zhendong Lei and Deli Wu}, doi = {10.1002/advs.202417368}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2417368}, shortjournal = {Adv. Sci.}, title = {Mechanochemical-triggered confined coordination of iron-biomass composites for efficient Cr(VI) reduction under circumneutral pH via accelerated electron extraction}, volume = {12}, year = {2025}, }
• (2025). “Antenna effect”-enhanced AuNPs@rGO photothermal coating promotes 3D printing of osteogenic active scaffolds to repair bone defects after malignant tumor surgery. ADVS, 12(15), 2417346. (www)

  @article{ , abstract = {Malignant bone tumor defects are difficult to treat because of the simultaneous need for tumor treatment and bone-repair promotion. This study presents a bioactive composite scaffold (T-rGO@Au) for personalized bone defect repair and bone tumor treatment. The T-rGO@Au scaffold has a porous structure, and its mechanical properties are close to those of human cancellous bone. The T-rGO@Au scaffold can induce upregulation of osteopontin (OPN), RUNX-2, and osteocalcin (OCN) gene expression. In vivo experiments showed that the bone volume/total volume (BV/TV) ratio with the T-rGO@Au scaffold was the highest. The new bone was tightly integrated with the implant, demonstrating effective osseointegration. The T-rGO@Au scaffold locally generated high temperatures and reactive oxygen species under near-infrared excitation, and AuNPs enhanced the photothermal performance of rGO through the “antenna effect.” Furthermore, in vitro experiments showed that the tumor cell nuclei were destroyed, late-stage apoptotic cells increased, and cell morphology was severely damaged. Additionally, RNA-seq revealed that tumor cell destruction was mediated through signaling pathways, such as the MAPK pathway. In vivo antitumor experiments also demonstrated that the T-rGO@Au scaffold significantly inhibited the growth of tumor cells within 2 weeks. Thus, the T-rGO@Au scaffold provides a new treatment strategy for the development of implantable scaffolds for bone tumor defects.}, archive = {J_ADVS}, author = {Xinyu Xu and Hao Wang and Xiaohan Mei and Dapeng Zeng and Zehao Yu and Shibo Liu and Ruiyan Li and Yanguo Qin}, doi = {10.1002/advs.202417346}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2417346}, shortjournal = {Adv. Sci.}, title = {“Antenna effect”-enhanced AuNPs@rGO photothermal coating promotes 3D printing of osteogenic active scaffolds to repair bone defects after malignant tumor surgery}, volume = {12}, year = {2025}, }
• (2025). Tailoring the structural evolution of multi-electron redox conversions via strong Selenium–Carbon interaction for robust aqueous copper-ion batteries. ADVS, 12(15), 2417084. (www)

  @article{ , abstract = {Aqueous metal-selenium batteries based on chalcogenide cathodes, despite their multi-electron conversion-type redox reactions and rapid kinetics, suffer from short lifespans and unclear capacity degradation mechanisms. The interfacial interactions between doped carbon and chalcogenides correlate closely with the electrochemical structural evolution. Hence, flower-like Cu 2−x Se wrapped with ultrathin N-doped carbon layer (Cu 2−x Se@N-C) is synthesized via a simple γ radiation-pyrolysis route for the first time. The Cu 2−x Se@N-C cathode displays a high-rate performance and long-term stability, with a respective capacity of 310.6 mAh g −1 at 20 A g −1 and a capacity retention rate of 92.9% after 30 000 cycles over 2000 h at 5 A g −1 . Ex situ X-ray diffraction and X-ray photoelectron spectroscopy confirm the reversible Cu storage mechanism of the Cu 2−x Se@N-C cathode and the issues of volume expansion and oxidative dissolution related to the capacity degradation of the Cu 2−x Se cathode. Furthermore, X-ray absorption analysis and theoretical calculations reveal the presence of Se─C interactions between the ultrathin N-doped carbon and Cu 2−x Se. As a result, the physical and chemical dual-protection of N-doped carbon via Se-C not only effectively stabilizes the structural evolution of Cu 2−x Se but also endows it with faster electrode reaction kinetics.}, archive = {J_ADVS}, author = {Fan Jiang and Haoyu Peng and Yiqian Wu and Yichen Li and Zeyu Zhang and Yue Wang and Jiuqiang Li and Jing Peng and Maolin Zhai}, doi = {10.1002/advs.202417084}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2417084}, shortjournal = {Adv. Sci.}, title = {Tailoring the structural evolution of multi-electron redox conversions via strong Selenium–Carbon interaction for robust aqueous copper-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Design of aromatic interaction networks in a protein cage modulated by fluorescent ligand binding. ADVS, 12(15), 2417030. (www)

  @article{ , abstract = {Dynamic behavior of proteins, such as orientation changes of aromatic residues, plays an important role in controlling biomolecular functions. Protein design that can precisely control such dynamic behavior at the atomic level is a challenging issue. The study reports the development of a system capable of orientational changes of aromatic side chains upon ligand binding. Aromatic pockets are constructed on the inner surfaces of protein cages to bind polycyclic aromatic fluorescent molecules to the targeted position by π–π stacking interactions. X-ray crystal structural analysis indicated the cooperative orientation changes of the aromatic clusters around the pocket triggered by the ligand binding. A comparison of various ligands shows that the movement of aromatic clusters can be controlled depending on the ligand structures. Fluorescence quantum yield and fluorescence lifetime are enhanced due to isolation of the fluorescent molecules in an aromatic pocket. These findings provide an understanding of the unique molecular behavior and fluorescence properties of ligands due to the assembly of aromatic residues and a guideline for developing dynamically controlled supramolecular biomaterials.}, archive = {J_ADVS}, author = {Yuki Hishikawa and Taiga Suzuki and Basudev Maity and Hiroki Noya and Michito Yoshizawa and Asuka Asanuma and Yuri Katagiri and Satoshi Abe and Satoru Nagatoishi and Kouhei Tsumoto and Takafumi Ueno}, doi = {10.1002/advs.202417030}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2417030}, shortjournal = {Adv. Sci.}, title = {Design of aromatic interaction networks in a protein cage modulated by fluorescent ligand binding}, volume = {12}, year = {2025}, }
• (2025). Achieving high-performance organic long persistent luminescence materials via manipulation of radical cation stability. ADVS, 12(15), 2416853. (www)

  @article{ , abstract = {Organic long persistent luminescence (OLPL) materials, with their hour-long afterglow, hold great promise across numerous applications, yet their performance lags behind that of inorganic counterparts. A deeper understanding of the underlying photophysical mechanisms, particularly the effective control of radical intermediates, is essential for developing high-performance OLPL materials; while systematic studies on the intrinsic stability of radical intermediates and their impact on OLPL performance remain scarce. Here biphenyl groups is introduced into a luminophore-matrix-donor three-component OLPL system. By varying substituents at the ortho-position of the biphenyl groups, the stability of radical cations is systematically modulated, and their influence on OLPL properties is investigated. Combined experimental results and theoretical calculations reveal that increased flexibility of the biphenyl bond and adjustable conformations lead to higher stability of radical cations, thereby significantly enhancing OLPL performance. Based on this understanding, a luminophore with two biphenyl groups is designed to successfully achieve remarkable afterglow brightness close to inorganic Sr 2 Al 14 O 25 /Eu 2+ , Dy 3+ materials. Furthermore, these OLPL materials exhibit time-encoded afterglow properties and promising applications in advanced anti-counterfeiting, as well as background-independent bioimaging functions. This work not only provides a novel strategy for constructing high-performance OLPL materials but also lays a foundation for their widespread application in various fields.}, archive = {J_ADVS}, author = {Hongxin Gao and Guangming Wang and Tengyue Wang and Zi Ye and Qianqian Yan and Qianhui Chong and Chin-Yiu Chan and Biaobing Wang and Kaka Zhang}, doi = {10.1002/advs.202416853}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416853}, shortjournal = {Adv. Sci.}, title = {Achieving high-performance organic long persistent luminescence materials via manipulation of radical cation stability}, volume = {12}, year = {2025}, }
• (2025). Effect of crystal symmetry of lead halide perovskites on the optical orientation of excitons. ADVS, 12(15), 2416782. (www)

  @article{ , abstract = {The great variety of lead halide perovskite semiconductors represents an outstanding platform for studying crystal symmetry effects on the spin-dependent properties. Access to them is granted through the optical orientation of exciton and carrier spins by circularly polarized photons. Here, the exciton spin polarization is investigated at 1.6 K cryogenic temperature in four lead halide perovskite crystals with different symmetries: (almost) cubic in FA 0.9 Cs 0.1 PbI 2.8 Br 0.2 and FAPbBr 3 , and orthorhombic in MAPbI 3 and CsPbBr 3 . Giant optical orientation of 85% is found for the excitons in FA 0.9 Cs 0.1 PbI 2.8 Br 0.2 , MAPbI 3 , and CsPbBr 3 , while it amounts to 20% in FAPbBr 3 . For all studied crystals, the optical orientation is robust to detuning of the laser photon energy from the exciton resonance, remaining constant for high energy detunings up to 0.3 eV, above which it continuously decreases to zero for detunings exceeding 1 eV. No acceleration of the spin relaxation for excitons with large kinetic energy is found in the cubic and orthorhombic crystals. This evidences the absence of the Dyakonov-Perel spin relaxation mechanism, which is based on the Rashba-Dresselhaus splitting of spin states at finite k -vectors. This indicates that the spatial inversion symmetry is maintained in perovskite crystals, independent of the cubic or orthorhombic phase.}, archive = {J_ADVS}, author = {Nataliia E. Kopteva and Dmitri R. Yakovlev and Eyüp Yalcin and Ina V. Kalitukha and Ilya A. Akimov and Mikhail O. Nestoklon and Bekir Turedi and Oleh Hordiichuk and Dmitry N. Dirin and Maksym V. Kovalenko and Manfred Bayer}, doi = {10.1002/advs.202416782}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416782}, shortjournal = {Adv. Sci.}, title = {Effect of crystal symmetry of lead halide perovskites on the optical orientation of excitons}, volume = {12}, year = {2025}, }
• (2025). Assembly and functionality of 2D protein arrays. ADVS, 12(15), 2416485. (www)

  @article{ , abstract = {Among the unique classes of 2D nanomaterials, 2D protein arrays garner increasing attention due to their remarkable structural stability, exceptional physiochemical properties, and tunable electronic and mechanical attributes. The interest in mimicking and surpassing the precise architecture and advanced functionality of natural protein systems drives the field of 2D protein assembly toward the development of sophisticated functional materials. Recent advancements deepen the understanding of the fundamental principles governing 2D protein self-assembly, accelerating the creation of novel functional biomaterials. These developments encompass biological, chemical, and templated strategies, facilitating the self-organization of proteins into highly ordered and intricate 2D patterns. Consequently, these 2D protein arrays create new opportunities for integrating diverse components, from small molecules to nanoparticles, thereby enhancing the performance and versatility of materials in various applications. This review comprehensively assesses the current state of 2D protein nanotechnology, highlighting the latest methodologies for directing protein assembly into precise 2D architectures. The transformative potential of 2D protein assemblies in designing next-generation biomaterials, particularly in areas such as biomedicine, catalysis, photosystems, and membrane filtration is also emphasized.}, archive = {J_ADVS}, author = {Mingming Du and Fanmeng Zeng and YueFei Wang and Ying Li and Guangcun Chen and Jiang Jiang and Qiangbin Wang}, doi = {10.1002/advs.202416485}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416485}, shortjournal = {Adv. Sci.}, title = {Assembly and functionality of 2D protein arrays}, volume = {12}, year = {2025}, }
• (2025). Ultrabroadband directional tunable thermal emission control based on vanadium dioxide photonic structures. ADVS, 12(15), 2416437. (www)

  @article{ , abstract = {The manipulation of thermal radiation amplitude or direction over a broadband spectrum is a fundamental capability, demonstrating significant potential in thermal management and infrared information encryption. However, existing approaches cannot control both aspects simultaneously. In this study, an ultrabroadband directional tunable thermal emitter (UDTTE) utilizing the metal-insulator transition properties of vanadium dioxide photonic structure and the Brewster effect is proposed. Before the phase transition, the UDTTE exhibits an average emissivity as low as 0.07 across the 3–20 µm band and the entire range of angles. After the phase transition, the UDTTE maintains a low emissivity of 0.33 for incident angles below 73° but displays a high emissivity of 0.78 in the 73°–83° range. This designed experiments in information encryption demonstrate that the UDTTE can synergistically utilize temperature, viewing angle, and polarization to achieve multi-level encryption of IR information. This strategy further enhances the capability to manipulate thermal radiation and holds promise for advancing technologies in information security, IR camouflage, and thermal management.}, archive = {J_ADVS}, author = {Qixiang Chen and Chengcong Li and Xuemei Huang and Yuehui Lu and Hua Xu and Yang An and Longnan Li and Wei Li and Xiaobo Yin and Xun Cao and Dongliang Zhao}, doi = {10.1002/advs.202416437}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416437}, shortjournal = {Adv. Sci.}, title = {Ultrabroadband directional tunable thermal emission control based on vanadium dioxide photonic structures}, volume = {12}, year = {2025}, }
• (2025). The transcription factor WFZP interacts with the chromatin remodeler TaSYD to regulate root architecture and nitrogen uptake efficiency in wheat. ADVS, 12(15), 2416433. (www)

  @article{ , abstract = {The root architecture is crucial for the robust growth and nutrient absorption in cereals. However, it is urgent to identify the factors that simultaneously optimize root architecture and nutrient utilization in wheat. In this study, a beneficial role of the class II AP2/ERF transcription factor WHEAT FRIZZY PANICLE (WFZP) on lateral root number (LRN), root length (RL), and nitrogen utilization is revealed. In addition, interactors of WFZP including TaSYD are identified, as a subunit of the chromatin remodeling complex. The Tasyd mutants show a significant reduction in LRN, RL, and nitrogen uptake efficiency, resembling the phenotype of wfzp mutants. Furthermore, it is revealed that the WFZP-TaSYD module promotes the expression of root development and nitrate uptake-related genes by modulating chromatin accessibility and histone modifications. Finally, an elite allele ( WFZP-A-I ) associated with improved LRN and thousand-grain weight (TGW) is identified. Hence, these findings not only unveil the mechanisms underlying the coordination of root development and nitrogen uptake efficiency, but also provide valuable targets for breeding high-yield crops.}, archive = {J_ADVS}, author = {Dejie Du and Zhaoju Li and Zihao Jiang and Jun Yuan and Xiangyu Zhang and Huanhuan Zhao and Lulu Tian and Yunjie Liu and Renhan Li and Fei He and Xiongtao Li and Wensheng Ke and Lingling Chai and Jie Liu and Mingming Xin and Yingyin Yao and Qixin Sun and Jiewen Xing and Zhongfu Ni}, doi = {10.1002/advs.202416433}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416433}, shortjournal = {Adv. Sci.}, title = {The transcription factor WFZP interacts with the chromatin remodeler TaSYD to regulate root architecture and nitrogen uptake efficiency in wheat}, volume = {12}, year = {2025}, }
• (2025). High strength, strain, and resilience of gold nanoparticle reinforced eutectogels for multifunctional sensors. ADVS, 12(15), 2416318. (www)

  @article{ , abstract = {Eutectogels with inherent ionic conductivity, mechanical flexibility, environment resistance, and cost-effectiveness have garnered considerable attention for the development of wearable devices. However, existing eutectogels rarely achieve a balance between strength, strain, and resilience, which are critical indicators of reliability in flexible electronics. Herein, poly(sodium styrenesulfonate) (PSS)-modified gold nanoparticles (AuNPs) in eutectic solvents are synthesized, and PSS-AuNP reinforced polyacrylic acid/polyvinylpyrrolidone (SAu-PAA/PVP) eutectogel is successfully prepared. Through the coordination between AuNPs and the PAA/PVP polymer chains, the SAu-PAA/PVP eutectogel exhibits significantly enhanced tensile strain (946%), mechanical strength (3.50 MPa), and resilience (85.3%). The high-performance eutectogel was demonstrated as a flexible sensor sensitive to strain and temperature, and the AuNPs provided near-infrared sensing capabilities. Furthermore, SAu-PAA/PVP eutectogel inherits the benefits of ES, including anti-drying and anti-freezing properties (−77 °C). Moreover, the eutectogel is microstructured using a simple molding method, and the resulting hierarchical pyramid microstructured eutectogel functions as ionic dielectric layer in a pressure sensor. This sensor exhibits high sensitivity (37.11 kPa −1 ), low detection limit (1 Pa), a fast response rate (36/54 ms), and excellent reproducibility over 5000 cycles, making them reliable and durable for detecting small vibrations, with potential applications in precision machinery, aerospace, and buildings.}, archive = {J_ADVS}, author = {Yingxiang Huang and Yanzhao Yang and Cong Peng and Yu Li and Wei Feng}, doi = {10.1002/advs.202416318}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416318}, shortjournal = {Adv. Sci.}, title = {High strength, strain, and resilience of gold nanoparticle reinforced eutectogels for multifunctional sensors}, volume = {12}, year = {2025}, }
• (2025). Biomimetic nanoplatform for targeted rheumatoid arthritis therapy: Modulating macrophage niches through self-sustaining positive feedback-driven drug release mechanisms. ADVS, 12(15), 2416265. (www)

  @article{ , abstract = {The core strategies in treating rheumatoid arthritis (RA) now focus on ameliorating the inflammatory microenvironment and reversing macrophage phenotypes within the joint cavity. This study introduces a co-delivery system of integrating nanoenzymes and gene therapeutics sequentially modified with guanidinium-based polymers and macrophage membranes to achieve synergistic therapeutic effects. This co-delivery system is named MACP siTNF-α nanoparticles (NPs). MACP siTNF-α nanoparticles are designed for targeted delivery to the inflamed joint site, where they are preferentially internalized by M1-type macrophages and efficiently evade lysosomal degradation. Subsequently, the co-delivery system operates efficiently via a self-sustaining positive feedback drug release mechanism. The biomimetic nanoplatform reduces reactive oxygen species (ROS) levels and prevents glutathione (GSH) depletion. GSH degrades the polymers to release small interfering RNA (siRNA) and expose the Prussian blue (PB) nanoenzymes, which effectively scavenge ROS and restore GSH levels. This feedback loop significantly enhances the gene silencing capability and ROS scavenging efficiency of the co-delivery system. In summary, MACP siTNF-α NPs can reverse macrophage ecological niche in inflammatory soils through the dual mechanism of efficiently inhibiting the expression of tumor necrosis factor-alpha (TNF-α) the upstream pathway of the inflammatory response, and eliminating ROS, thus realizing efficient treatment of RA.}, archive = {J_ADVS}, author = {Huichao Xie and Xiaoyu Huang and Bao Li and Yongfeng Chen and Haoran Niu and Tong Yu and Shimei Yang and Shuxin Gao and Yutong Zeng and Tianzhi Yang and Yan Kang and Keda Zhang and Pingtian Ding}, doi = {10.1002/advs.202416265}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416265}, shortjournal = {Adv. Sci.}, title = {Biomimetic nanoplatform for targeted rheumatoid arthritis therapy: Modulating macrophage niches through self-sustaining positive feedback-driven drug release mechanisms}, volume = {12}, year = {2025}, }
• (2025). Non-membrane active peptide resensitizes MRSA to β-lactam antibiotics and inhibits s. aureus virulence. ADVS, 12(15), 2416260. (www)

  @article{ , abstract = {Methicillin-resistant Staphylococcus aureus (MRSA) is a serious global health threat due to its high morbidity and mortality rates, creating a dire need for novel therapeutic strategies. Antimicrobial peptides (AMPs), with broad-spectrum activity and low propensity for resistance development, show promise as effective antibiotic adjuvants to reverse multidrug-resistance in bacteria. Herein, it is uncovered that a potent and non-toxic AMP termed GN1 substantially resensitizes MRSA to multiple β -lactam antibiotics at low concentrations. Mechanistic studies indicate that GN1 functions by suppressing both the production and enzymatic activity of MRSA-associated resistance determinants, including penicillin-binding protein 2a (PBP2a) and β -lactamase. Additionally, GN1 exhibits a robust anti-virulence profile by inhibiting MRSA biofilm formation and staphyloxanthin production. Furthermore, GN1 induces bacterial metabolic perturbation, resulting in glutamate accumulation and oxidative damage. Importantly, the combination of GN1 with β -lactam antibiotics effectively mitigates MRSA-induced infections in the animal infection models. Collectively, these findings suggest that GN1 represents a potent β -lactam adjuvant and anti-virulence agent, offering a safe and versatile solution to combat MRSA infections.}, archive = {J_ADVS}, author = {Jingru Shi and Chen Chen and Pan Kong and Feiyu Yu and Qingyan Lv and Zhiqiang Wang and Yuan Liu}, doi = {10.1002/advs.202416260}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416260}, shortjournal = {Adv. Sci.}, title = {Non-membrane active peptide resensitizes MRSA to β-lactam antibiotics and inhibits s. aureus virulence}, volume = {12}, year = {2025}, }
• (2025). Disruption of the eEF1A1/ARID3A/PKC-δ complex by neferine inhibits macrophage glycolytic reprogramming in atherosclerosis. ADVS, 12(15), 2416158. (www)

  @article{ , abstract = {Glycolytic reprogramming of macrophages is a decisive factor in atherosclerosis (AS) plaque formation. Eukaryotic elongation factor 1A1 (eEF1A1) plays an important role in protein synthesis, ubiquitination degradation, and nuclear translocation. However, the potential function of eEF1A1 in AS has not yet been fully understood. Here, the natural small molecule neferine (Nef), which targets eEF1A1 to suppress macrophage glycolytic reprogramming is discovered. In this work, chemical genetics and non-modified target confirmation assays are used to confirm that eEF1A1 is a direct target of Nef. Mechanically, Nef disrupted the formation of the eEF1A1/ARID3A/PKC-δ complex, inhibits phosphorylation of ARID3A at Thr491, and consequently prevents its nuclear translocation. Meanwhile, it is verified that ARID3A is a transcriptional regulator of enolase 2 (ENO2), an important enzyme in the glycolytic process. Nef suppresses ENO2 transcription activation by affecting ARID3A binding to the promoter region of ENO2, which results in macrophage glycolytic reprogramming inhibition and transformation of macrophages from M1 to M2. Collectively, these findings provide an attractive future direction for AS therapy by inhibiting ARID3A/ENO2-mediated macrophage glycolytic reprogramming by targeting eEF1A1.}, archive = {J_ADVS}, author = {Baoping Xie and Li-Wen Tian and Chenxu Liu and Jiahua Li and Xiaoyu Tian and Rong Zhang and Fan Zhang and Zhongqiu Liu and Yuanyuan Cheng}, doi = {10.1002/advs.202416158}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2416158}, shortjournal = {Adv. Sci.}, title = {Disruption of the eEF1A1/ARID3A/PKC-δ complex by neferine inhibits macrophage glycolytic reprogramming in atherosclerosis}, volume = {12}, year = {2025}, }
• (2025). LIMA1 O-GlcNAcylation promotes hepatic lipid deposition through inducing β-catenin-regulated FASn expression in metabolic dysfunction-associated steatotic liver disease. ADVS, 12(15), 2415941. (www)

  @article{ , abstract = {Hepatic lipid deposition is a key factor in progressing metabolic dysfunction-associated steatotic liver disease (MASLD). This study investigates the impact of the LIM domain and actin-binding protein 1 (LIMA1) on hepatic steatotic in MASLD and explore the underlying mechanisms. Increased levels of LIMA1 is observed in both serum and serum sEV of metabolic dysfunction-associated steatohepatitis (MASH) patients compared to healthy controls, with AUROC values of 0.76 and 0.86, respectively. Furthermore, increased LIMA1 O-GlcNAcylation is observed in mouse models of MASLD, and steatotic hepatocytes. Mechanistic studies revealed that steatosis upregulated Host cell factor 1 (HCF1) and O-GlcNAc transferase (OGT) expression, leading to catalyzed O-GlcNAcylation at the T662 site of LIMA1 and subsequent inhibition of its ubiquitin-dependent degradation. O-GlcNAcylation of LIMA1 enhances hepatocyte lipid deposition by activating β-catenin/FASn-associated signaling. Additionally, compared with their AAV8-TBG-LIMA1-WT counterparts, AAV8-TBG-LIMA1 ΔT662 injection exhibited decreases in systemic insulin resistance, steatosis severity, inflammation and fibrosis in HFD-fed and CDAHFD-fed LIMA1 HKO (hepatocyte-specific knockout) mice. Moreover, LTH-sEV-mediated delivery of LIMA1 promoted MASLD progression by promoting hepatic stellate cell (HSC) activation. The findings suggest that serum sEV LIMA1 may be a potential noninvasive biomarker and therapeutic target for individuals with MASH.}, archive = {J_ADVS}, author = {Fuji Yang and Yifei Chen and Guojun Zheng and Kefeng Gu and Lin Fan and Tingfen Li and Ling Zhu and Yongmin Yan}, doi = {10.1002/advs.202415941}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2415941}, shortjournal = {Adv. Sci.}, title = {LIMA1 O-GlcNAcylation promotes hepatic lipid deposition through inducing β-catenin-regulated FASn expression in metabolic dysfunction-associated steatotic liver disease}, volume = {12}, year = {2025}, }
• (2025). Interface-confined catalytic synthesis of anisotropic covalent organic framework nanofilm for ultrafast molecular sieving. ADVS, 12(15), 2415520. (www)

  @article{ , abstract = {Covalent organic frameworks (COFs) have emerged as prominent membrane materials for efficiently fractionating organic molecules and ions due to their unique pore structure. However, the fabrication of free-standing COF nanofilms with high crystallinity remains an arduous undertaking, and feasible methods that can enable precise control over the film microstructure are barely reported. This work conceives an exquisite interface-confined catalytic strategy to prepare Tp-BD(OH) 2 COF nanofilm with an anisotropic structure analogously to conventional polymeric membranes. Experimental data and molecular simulations reveal that the hydroxyl groups on the framework substantially capture and anchor the acid catalyst through hydrogen bonding interactions at the incipient stage of interfacial polycondensation, instigating confined catalysis and self-termination reaction at the interface. The distinctive asymmetric structure endows the Tp-BD(OH) 2 COF nanofilm with a record-breaking pure water permeance of 525.3 L m −2 h −1 bar −1 and unprecedented dye/salt selectivity of 648.6, surpassing other reported COF films and state-of-the-art nanofiltration membranes, as well as enduring structural durability and chemical stability. The implemented interface-confined catalysis strategy opens up a new avenue for regulating the COF nanofilm microstructure and holds broad prospects for the rational design of high-performance membranes for sustainable water purification and treatment.}, archive = {J_ADVS}, author = {Jiahao Tang and Yu Liao and Zhenxiang Pan and Songjun Fang and Mingxiu Tang and Lu Shao and Gang Han}, doi = {10.1002/advs.202415520}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2415520}, shortjournal = {Adv. Sci.}, title = {Interface-confined catalytic synthesis of anisotropic covalent organic framework nanofilm for ultrafast molecular sieving}, volume = {12}, year = {2025}, }
• (2025). Impact of the sulfurized polyacrylonitrile cathode microstructure on the electrochemical performance of Lithium–Sulfur batteries. ADVS, 12(15), 2415436. (www)

  @article{ , abstract = {The growing demand for advanced energy storage systems requires the development of next-generation battery technologies with superior energy density and cycle stability, with lithium–sulfur (Li–S) batteries representing a promising solution. Sulfur-containing polyacrylonitrile cathodes (SPAN) for Li–S batteries are a significant advancement for this next-generation battery chemistry, addressing the major issue of limited cycle life encountered in conventional carbon/sulfur composite cathodes. In the presented study, the influence of available ionic and electronic conduction pathways within the cathode on the electrochemical performance of SPAN-based Li–S batteries is studied in details. To this end, a series of SPAN cathodes with different microstructures is prepared by adapting the compression degree of calendering. Mechanical and morphological characterizations confirm a pronounced springback effect due to a characteristic elastic deformation behavior of SPAN. Electrochemical impedance spectroscopy (EIS) shows increased cathode impedance values with multiple overlapping processes in the high- to mid-frequency region in highly compressed SPAN cathodes. Moreover, while the (first) discharge capacity is unaffected, the subsequent charge capacity decreases substantially for highly compressed cathodes. The electrochemical experiments and electrochemical continuum simulations confirm that this phenomenon is mainly due to the disturbance of the electronic percolation pathways caused by the springback behavior during calendering.}, archive = {J_ADVS}, author = {Robin Moschner and Martina Gerle and Timo Danner and Esther Kezia Simanjuntak and Peter Michalowski and Arnulf Latz and Maryam Nojabaee and Arno Kwade and K. A. Friedrich}, doi = {10.1002/advs.202415436}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2415436}, shortjournal = {Adv. Sci.}, title = {Impact of the sulfurized polyacrylonitrile cathode microstructure on the electrochemical performance of Lithium–Sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). Identification of three distinct subgroups in antiphospholipid syndrome: Implication for sex differences and prognostic outcomes from a multicenter study. ADVS, 12(15), 2415291. (www)

  @article{ , abstract = {Antiphospholipid syndrome (APS) is a heterogeneous autoimmune disease with persistent antiphospholipid antibodies. This study aimed to identify unrecognized APS subgroups from multicenter cohorts ( n = 760, training: n = 415; validation: n = 345). Patients are stratified through unsupervised K-means clustering analysis. Prognostic outcomes are evaluated using Kaplan-Meier survival analyses. Proteomic analysis is conducted on primary APS patients ( n = 36) and healthy controls ( n = 12). Key molecule insulin-like growth factor 1 is validated using ELISA. Three clusters are identified. Cluster 1 ( n = 320, 42.1%) is completely consisted of females (100%), with predominant occurrence of pregnancy morbidity (88.8%) but low incidences of thrombocytopenia (18.4%) and thrombosis (15.0%), and a favorable prognosis. Cluster 2 ( n = 309, 40.7%) is predominantly female (99.4%) and characterized by high thrombosis (85.8%) and thrombocytopenia (46.6%), low pregnancy morbidity (13.6%), and poor prognosis. Cluster 3 ( n = 131, 17.2%) is predominantly male (99.2%), exhibiting highest thrombosis (96.2%) and moderate thrombocytopenia (32.8%), with worst prognosis. Immunological and proteomic analyses clearly differentiated three clusters. This study reveals a distinct difference between obstetric and thrombotic APS, and a sex-based distinction within thrombotic APS. Three APS subgroups display unique clinical and molecular characteristics, and marked difference in prognostic outcomes.}, archive = {J_ADVS}, author = {Chen Chen and Ao Zhang and Jianhui Cheng and Zhongqiang Yao and Juan Meng and Yilu Qin and Qingyi Lu and Yufei Li and Xiangjun Liu and Tianhao Li and Chao Hou and Yundi Tang and Hongjiang Liu and Ning Xu and Sai Dong and Xinxin Li and Fangmin Xu and Jianping Guo and Chun Li}, doi = {10.1002/advs.202415291}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2415291}, shortjournal = {Adv. Sci.}, title = {Identification of three distinct subgroups in antiphospholipid syndrome: Implication for sex differences and prognostic outcomes from a multicenter study}, volume = {12}, year = {2025}, }
• (2025). Development of self-aligned top-gate transistor arrays on wafer-scale two-dimensional semiconductor. ADVS, 12(15), 2415250. (www)

  @article{ , abstract = {Two-dimensional semiconductor materials (2DSM) effectively mitigate the short-channel effect due to their atomic thickness, offering significant advantages over traditional silicon-based materials, particularly in short channel length. In manufacturing 2DSM top-gate field-effect transistors (TG-FETs), simultaneous miniaturization of the gate and channel can only be achieved through a self-alignment process, enabling high-density integration of short-channel FETs. However, current self-aligned FETs based on 2DSM face challenges in attaining wafer-scale integration due to manufacturing process limitations. This work has successfully developed high-performance and wafer-scale TG-FET arrays using a self-aligned method that integrates the processes of dry etching, wet selective etching, and post-device optimization. The miniaturization is demonstrated by fabricating TG-FETs with a channel length of 200 nm, achieving an impressive on-state current density of 465.5 µA µm −1 and a high on-off current ratio of 10 8 . Furthermore, we constructed the inverters and logic modules based on self-aligned FETs, showcasing the process's compatibility for future integration.}, archive = {J_ADVS}, author = {Yuxuan Zhu and Jinshu Zhang and Hui Xie and Yin Xia and Xiangqi Dong and Saifei Gou and Zhejia Zhang and Xinliu He and Haojie Chen and Mingrui Ao and Qicheng Sun and Yan Hu and Yuchen Tian and Jieya Shang and Yufei Song and Jiahao Wang and Sen Wang and Xiaofei Yue and Chunxiao Cong and Lihui Zhou and Sheng Dai and Zihan Xu and Jing Wan and Haibing Qiu and Yin Wang and Xiaojun Tan and Wenzhong Bao}, doi = {10.1002/advs.202415250}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2415250}, shortjournal = {Adv. Sci.}, title = {Development of self-aligned top-gate transistor arrays on wafer-scale two-dimensional semiconductor}, volume = {12}, year = {2025}, }
• (2025). Tunable hierarchically porous gadolinium-based metal-organic frameworks for bacteria-targeting magnetic resonance imaging and in situ anti-bacterial therapy. ADVS, 12(15), 2415209. (www)

  @article{ , abstract = {Currently, there are no non-invasive tools to accurately diagnose deep surgical site bacterial infections before they cause significant anatomical damage in the clinic. An urgent need exists for bacteria-targeting bifunctional probes for the detection of deep bacterial infections and precise in situ treatment. Herein, the bacteria-targeting 1-borono-3,5-benzenedicarboxylic acid (BBDC) ligand and paramagnetic Gd 3 + into one single metal-organic frameworks (MOFs) are integrated, synergistically realizing bacteria-specific magnetic resonance imaging (MRI) diagnosis and MRI-guided antibacterial treatment. Molecular simulations and nitrogen adsorption-desorption experiments demonstrate that a hierarchical porous structure can be constructed by tuning the Gd 3 + /BBDC ratio, which endows the Gd-BBDC1.25 MOFs with an impressive longitudinal proton relaxivity of 15.81 mM −1 s −1 . In particular, the bacteria-targeting boronic acid group in BBDC remained intact during the MOF synthesis, ensuring that Gd-BBDC1.25 MOFs have a unique combination of high sensitivity and specificity for bacteria. Through an in situ reduction reaction, silver nanoparticles （Ag NPs）-modified Gd-BBDC1.25 MOFs to form Ag@Gd-BBDC1.25, an interfacial Schottky heterojunction nanozyme, which enhances their peroxidase (POD)-catalyze activity. Furthermore, it is demonstrated that the bacteria-targeting Ag@Gd-BBDC1.25 bifunctional probe can image as few as 10 5 colony-forming units (cfu) in vivo and effectively eradicate the bacteria in situ.}, archive = {J_ADVS}, author = {Youyi Yu and Tianming Cui and Chang Liu and Weitao Yang and Bingbo Zhang}, doi = {10.1002/advs.202415209}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2415209}, shortjournal = {Adv. Sci.}, title = {Tunable hierarchically porous gadolinium-based metal-organic frameworks for bacteria-targeting magnetic resonance imaging and in situ anti-bacterial therapy}, volume = {12}, year = {2025}, }
• (2025). A methionine allocation nanoregulator for the suppression of cancer stem cells and support to the immune cells by epigenetic regulation. ADVS, 12(15), 2415207. (www)

  @article{ , abstract = {Epigenetic dysregulation is prevalent in human cancers, affecting gene expression and metabolic patterns to meet the demands of malignant evolution and abnormal epigenetic processes, and resulting in a protumor immune microenvironment. Tumors require a steady supply of methionine for maintaining epigenetic flexibility, which is the only exogenous precursor of methyl donor S-adenosylmethionine for methylation, crucial for their resistance to therapies and survival in a nutrient-deficient microenvironment. Thus, tumor cells upregulate the Lat4 transporter to compete and deprive methionine in the microenvironment, sustaining their malignant phenotypes and also impairing immune cell functions. Addressing this methionine addiction is the key to overcoming drug resistance and improving immune response. Despite the challenge of lacking specific Lat4 inhibitors, an oxaliplatin prodrug crosslinked fluorinated polycation/anti-Lat4 small interfering RNA complex nanoregulator (AS-F-NP) has been designed and developed here. This nanoregulator restricted the greedy methionine uptake of tumor cells by knocking down Lat4, which in turn inhibited the malignant evolution of the tumor while restoring the viability and function of tumor-infiltrating immune cells.}, archive = {J_ADVS}, author = {Boyu Su and Qinjun Chen and Xuwen Li and Mingzhu Fang and Yu Wang and Haolin Song and Haoyu You and Zheng Zhou and Yuxing Wu and Zhenhao Zhao and Yun Chen and Hongrui Fan and Chufeng Li and Chen Jiang and Tao Sun}, doi = {10.1002/advs.202415207}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2415207}, shortjournal = {Adv. Sci.}, title = {A methionine allocation nanoregulator for the suppression of cancer stem cells and support to the immune cells by epigenetic regulation}, volume = {12}, year = {2025}, }
• (2025). Broadband acoustic purcell effect from collective bound states in the continuum. ADVS, 12(15), 2414627. (www)

  @article{ , abstract = {The Purcell effect significantly improves the performance of various emission devices but is typically constrained by a narrow operational bandwidth due to inherent resonant mechanisms. This study achieves broadband acoustic Purcell effect, substantially boosting sound emission by exploring collective quasibound states in the continuum (QBICs). A six-cavity coupled system supporting five QBICs is introduced, wherein all of the QBICs interact strongly with an acoustic source. This system takes advantage of the high quality factors and the strong mode responses of the collective QBICs, leading to a substantial enhancement of the local density of states. Consequently, a considerable increase in sound emission is realized across the frequency range of 625–900 Hz. These findings provide insights into the physical mechanisms driving the broadband Purcell effect in resonant systems and open up promising avenues for the development of advanced acoustic emission devices.}, archive = {J_ADVS}, author = {Sibo Huang and Shuhuan Xie and Tuo Liu and Tong Hao and Din Ping Tsai and Yong Li and Jie Zhu}, doi = {10.1002/advs.202414627}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2414627}, shortjournal = {Adv. Sci.}, title = {Broadband acoustic purcell effect from collective bound states in the continuum}, volume = {12}, year = {2025}, }
• (2025). Dimethyl sulfoxide and sodium chloride modulate the crystal structure in PMIA to enhance dyeing performance: Molecular dynamics simulation and experimental investigations. ADVS, 12(15), 2414544. (www)

  @article{ , abstract = {The widespread use of meta-aramid (PMIA) is limited by its poor dyeing performance, and researchers often struggle to qualitatively and quantitatively assess its microscopic structural regulation when attempting to improve dyeing performance. Herein, DMSO/NaCl is chosen to synergistically modulate the structure of PMIA to improve its dyeing properties in combination with experiments and simulations. Initially, characterization and color testing reveal that the DMSO/NaCl combination induces structural changes in the amorphous regions of the PMIA fiber, improving the dispersion of the dye solution. Notably, PMIA exhibited a significant improvement in dyeing performance, with the K/S value increasing from 2.6 to 16.0 and dye uptake rising from 20.4% to 73.2%, while maintaining excellent colorfastness and mechanical integrity. Molecular dynamics simulations further confirm that DMSO/NaCl disrupts the hydrogen bonding network in the amorphous regions of PMIA, enhancing the mobility of molecular chains and increasing the free volume, thus providing additional adsorption and binding sites for the dye molecules. These findings highlight the potential of combining experimental and computational approaches to optimize the structural regulation and dyeing performance of PMIA fibers.}, archive = {J_ADVS}, author = {Yan Zhuo and Kuang Wang and Minghui Chen and Zhengke Fan and Zhuangzhuang Sun and Jianli Liu and Yizheng Fu and Aixue Dong and Bo Zhu}, doi = {10.1002/advs.202414544}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2414544}, shortjournal = {Adv. Sci.}, title = {Dimethyl sulfoxide and sodium chloride modulate the crystal structure in PMIA to enhance dyeing performance: Molecular dynamics simulation and experimental investigations}, volume = {12}, year = {2025}, }
• (2025). Control of rhizobia endosymbiosis by coupling ER expansion with enhanced UPR. ADVS, 12(15), 2414519. (www)

  @article{ , abstract = {Legumes establish symbiosis with rhizobia by forming a symbiotic interface that enables cross-kingdom exchanges of signaling molecules and nutrients. However, how host organelles interact with symbiosomes at the symbiotic interface remains elusive during rhizobia endosymbiosis. Here, symbiotic cells are reconstructed using 3D scanning electron microscopy (SEM) and uncover that the host endoplasmic reticulum (ER) undergoes dynamic expansion to gradually enwrap symbiosomes, facilitating their compartmentalization and endosymbiosis. Consistently, altering ER lamellar expansion by overexpressing MtRTNLBs , the reticulons responsible for ER tubulation, impairs rhizobia accommodation and symbiosome development. Intriguingly, unfolded protein response (UPR)-marker genes, bZIP60 and IRE1A/B , show continuously activated expression during nodule development, and the two UPR-deficient mutants, ire1b , and bzip60 , exhibit compromised ER biogenesis and defective symbiosome development. Collectively, the findings underpin ER expansion and UPR activation as two key events in rhizobia accommodation and reveal an intrinsic coupling of ER morphology with proper UPR during root nodule symbiosis.}, archive = {J_ADVS}, author = {Jing Ren and Qi Wang and Xiaxia Zhang and Yongheng Cao and JingXia Wu and Juan Tian and Yanjun Yu and Qingqiu Gong and Zhaosheng Kong}, doi = {10.1002/advs.202414519}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2414519}, shortjournal = {Adv. Sci.}, title = {Control of rhizobia endosymbiosis by coupling ER expansion with enhanced UPR}, volume = {12}, year = {2025}, }
• (2025). PTAA-based perovskite photovoltaics catching up: Ionic liquid engineering-assisted crystallization through sequential deposition. ADVS, 12(15), 2414515. (www)

  @article{ , abstract = {PTAA as a widely studied polymeric hole transporting material, has garnered significant attention due to its outstanding thermal and chemical stability. However, the performance of PTAA-based p-i-n devices is shown to lag behind counterpart utilizing oxides or SAMs. In this study, the ionic liquid, 1-ethyl-3-methylimidazolium formate (EMIMCOOH), is innovatively introduced into the lead iodide (PbI 2 ) precursor solution, resulting in a more pronounced mesoporous PbI 2 film with expended pore-size and denser pores. This enhancement is attributed to the coordination bond between the ─C═O group in EMIMCOOH and Pb 2+ . This intensified mesoporous morphology not only facilities the reaction between PbI 2 and the organic layer, but also promotes the PbI 2 conversion into perovskite material. Importantly, the incorporation of EMIMCOOH slows down the perovskite conversion process, increasing perovskite domain size and suppressed Pb 0 trap density, resulting in a uniform perovskite layer with enhanced charge transport properties, as evidenced by the conducting atomic force microscope (c-AFM) results. As a result, the incorporation of EMIMCOOH yields a power conversion efficiency (PCE) of 24.10% and a high fill factor exceeding 85%. Notably, the PCE of the EMIMCOOH-modified device can still maintain 86% of the initial value after 1500 h at 25 °C in an N 2 atmosphere.}, archive = {J_ADVS}, author = {Yongjun Li and Fei Wang and Qiannan Li and Baolei Tang and Yonggui Sun and Taomiao Wang and Xiao Liang and Jing Ma and Xianfang Zhou and Fan Zhang and Xing'ao Li and Yao Tong and Ruiyuan Hu and Mingjian Yuan and Tom Wu and Annie Ng and Hanlin Hu}, doi = {10.1002/advs.202414515}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2414515}, shortjournal = {Adv. Sci.}, title = {PTAA-based perovskite photovoltaics catching up: Ionic liquid engineering-assisted crystallization through sequential deposition}, volume = {12}, year = {2025}, }
• (2025). Anti-motion artifacts iontronic sensor for long-term accurate fingertip pulse monitoring. ADVS, 12(15), 2414425. (www)

  @article{ , abstract = {Flexible pressure sensors have gained attention for their comfort, portability, and potential in long-term pulse monitoring and early cardiovascular disease diagnosis. However, stretching stress during daily activities affects sensor accuracy, causing motion artifacts (MAs) that hinder precise pulse signal detection. To address this challenge, the anti-motion artifact iontronic pressure sensor (S-smooth sensor), featuring a soft-hard stretchable interface with energy dissipation properties is developed. By regulating the local modulus of the encapsulation layer, this structure dissipates stretching stress, achieving an MAs suppression rate of up to 90%, significantly improving pulse signal accuracy and reliability. Additionally, the sensor incorporates a dielectric layer and double electrode layer (EDL) sensing interface, with a low-friction design that ensures high sensitivity (92.76 kPa−¹) and stability, maintaining performance over millions of cycles. The sensor accurately captures heart rate (HR) and pulse peak time differences (Δt) under various finger-bending conditions. When integrated into a portable wireless pulse monitoring system, it shows a heart rate loss rate of only 2.9% during intense physical activity. This approach avoids complex chemical processes and material restrictions, offering a novel solution for motion artifact suppression in sensors, with significant potential for real-time health monitoring and assisted diagnosis.}, archive = {J_ADVS}, author = {Jia You and Mingyang Lu and Lamu Dazhen and Mengjie Gao and Ruiyan Zhang and Wendong Li and Fan Lei and Wei Ren and Guangxian Li and Junlong Yang}, doi = {10.1002/advs.202414425}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2414425}, shortjournal = {Adv. Sci.}, title = {Anti-motion artifacts iontronic sensor for long-term accurate fingertip pulse monitoring}, volume = {12}, year = {2025}, }
• (2025). Fabrication of graphene polyhedra: Unveiling new structures, forms, and properties. ADVS, 12(15), 2414108. (www)

  @article{ , abstract = {A hybrid nanoporous carbon alloy material is synthesized using a core–shell structure based on metal–organic frameworks, revealing a novel graphene polyhedral form. The presence of carbon and metal as doped cobalt carbides based on morphed graphene within the graphene polyhedra is confirmed through a combination of X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscopy, and Raman spectroscopy analyses. These novel graphene polyhedra exhibit magnetoelectric coupling properties at room temperature. The magnetic state control is verified using a magnetic probe; the changes in the magnetic state increased with a higher applied bias, and the poling direction of the magnetic phase is reversed based on the scanning direction of the probe. This discovery holds promise for future applications in ultrafast devices and carbon-based spintronics research.}, archive = {J_ADVS}, author = {Joong Yeon Lim and Seonghwan Kim and Muhammad Toyabur Rahman and Young-Seong Kim}, doi = {10.1002/advs.202414108}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2414108}, shortjournal = {Adv. Sci.}, title = {Fabrication of graphene polyhedra: Unveiling new structures, forms, and properties}, volume = {12}, year = {2025}, }
• (2025). Electrical control of magnetic order transition in 2D antiferromagnetic semiconductor FePS3. ADVS, 12(15), 2413892. (www)

  @article{ , abstract = {Manipulating the magnetic order transition of 2D magnetic materials is an important way for the application of spintronic devices, and carrier concentration modulation is a commonly used effective regulation method. Here the magnetic ground state of FePS 3 is tuned from antiferromagnetic (AFM) to ferrimagnetic (FIM) and back to AFM by electron doping, which is achieved via the intercalation of various organic cations. The doped FePS 3 with FIM order exhibits a Curie temperature T c of ≈110 K, a strong out-of-plane magnetic anisotropy, and particularly an unusual hysteresis loop, where with increasing temperature, the area of magnetic hysteresis loop increases below 50 K, then decreases above 50 K and eventually disappears. Theoretical calculations indicate that at a doping concentration of 0.3–0.9 electrons per cell, spin splitting of energy bands occurs, leading to the FIM order; whereas at a doping concentration of ≥ 1.0 electrons per cell, the AFM order recovers. Such AFM-FIM-AFM transition is ascribed to the competition between the Stoner exchange-dominated FM order and super-exchange-dominated AFM order. These results demonstrate an effective approach to engineering magnetism in 2D magnetic materials by purely electrical means for future device applications.}, archive = {J_ADVS}, author = {Mengjuan Mi and Qing Zhang and Shilei Wang and Xiandong Zhang and Han Xiao and Lixuan Yu and Houning Song and Chao Ma and Shuang Dai and Bingbing lyu and Jiyu Fan and Bing Shen and Fangsen Li and Yanxue Chen and Min Liu and Shanpeng Wang and Xiaohui Liu and Yilin Wang}, doi = {10.1002/advs.202413892}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413892}, shortjournal = {Adv. Sci.}, title = {Electrical control of magnetic order transition in 2D antiferromagnetic semiconductor FePS3}, volume = {12}, year = {2025}, }
• (2025). Hybrid EMT phenotype and cell membrane tension promote colorectal cancer resistance to ferroptosis. ADVS, 12(15), 2413882. (www)

  @article{ , abstract = {Intratumoral heterogeneity, including epithelial–mesenchymal transition (EMT), is one major cause of therapeutic resistance. The induction of ferroptosis, an iron-dependent death, has the potential in overcoming this resistance to traditional treatment modalities. However, the roles of distinct EMT phenotypes in ferroptosis remain an enigma. This study reports that 3D soft fibrin microenvironment confers colorectal cancer (CRC) cells hybrid EMT phenotype and high level of resistance to ferroptosis. The activation of histone acetylation and WNT/β-catenin signaling drives this EMT phenotypic transition, which promotes the defense of 3D CRCs against ferroptosis via glutathione peroxidases/ferritin signaling axis. Unexpectedly, E-cadherin knockout in 3D but not 2D CRCs mediates an integrin β 3 marked-late hybrid EMT state and further enhances the resistance to ferroptosis via integrin-mediated tension and mitochondrial reprogramming. The inhibition of integrin α v β 3 -mediated tension and WNT/β-catenin-mediated hybrid EMT sensitizes 3D CRCs with and without E-cadherin deficiency to ferroptosis in vivo, respectively. Further, the EMT phenotype of patient-derived tumoroids is associated with CRC therapeutic resistance. In summary, this study uncovers previously unappreciated roles of hybrid EMT and cell membrane tension in ferroptosis, which not only predict the treatment efficacy but also potentiate the development of new ferroptosis-based targeted therapeutic strategies.}, archive = {J_ADVS}, author = {Xiaowei Wei and Yutong Ge and Yaolin Zheng and Sunyan Zhao and Yuhan Zhou and Yuhan Chang and Nuofan Wang and Xiumei Wang and Juan Zhang and Xuanchang Zhang and Liqiao Hu and Youhua Tan and Qiong Jia}, doi = {10.1002/advs.202413882}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413882}, shortjournal = {Adv. Sci.}, title = {Hybrid EMT phenotype and cell membrane tension promote colorectal cancer resistance to ferroptosis}, volume = {12}, year = {2025}, }
• (2025). Psychedelic drugs in mental disorders: Current clinical scope and deep learning-based advanced perspectives. ADVS, 12(15), 2413786. (www)

  @article{ , abstract = {Mental disorders are a representative type of brain disorder, including anxiety, major depressive depression (MDD), and autism spectrum disorder (ASD), that are caused by multiple etiologies, including genetic heterogeneity, epigenetic dysregulation, and aberrant morphological and biochemical conditions. Psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have been renewed as fascinating treatment options and have gradually demonstrated potential therapeutic effects in mental disorders. However, the multifaceted conditions of psychiatric disorders resulting from individuality, complex genetic interplay, and intricate neural circuits impact the systemic pharmacology of psychedelics, which disturbs the integration of mechanisms that may result in dissimilar medicinal efficiency. The precise prescription of psychedelic drugs remains unclear, and advanced approaches are needed to optimize drug development. Here, recent studies demonstrating the diverse pharmacological effects of psychedelics in mental disorders are reviewed, and emerging perspectives on structural function, the microbiota-gut-brain axis, and the transcriptome are discussed. Moreover, the applicability of deep learning is highlighted for the development of drugs on the basis of big data. These approaches may provide insight into pharmacological mechanisms and interindividual factors to enhance drug discovery and development for advanced precision medicine.}, archive = {J_ADVS}, author = {Sung-Hyun Kim and Sumin Yang and Jeehye Jung and Jeonghyeon Choi and Mingon Kang and Jae-Yeol Joo}, doi = {10.1002/advs.202413786}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413786}, shortjournal = {Adv. Sci.}, title = {Psychedelic drugs in mental disorders: Current clinical scope and deep learning-based advanced perspectives}, volume = {12}, year = {2025}, }
• (2025). Using large language model to optimize protein purification: Insights from protein structure literature associated with protein data bank. ADVS, 12(15), 2413689. (www)

  @article{ , abstract = {Obtaining pure and homogeneous protein samples is vital for protein biology studies, yet optimizing protein expression and purification methods can be time-consuming because of variations in factors like expression conditions, buffer components, and fusion tags. With over 81 000 Protein Data Bank (PDB)-associated articles as of October 2024, manual extraction of relevant methods is impractical. To streamline this process, an automated tool is developed by incorporating a large language model (LLM) to extract and classify key data from these articles. The information extraction accuracy is enhanced by a 2-step-LLM and a 3-step-prompt. The key findings include: 1) Tris buffer is used in 49.2% of cases, followed by 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) and phosphate buffers. 2) Polyhistidine tags dominate at 82.5%, followed by glutathione S-transferase (GST) and maltose-binding protein (MBP) tags. 3) E. coli expression is done at 16–20 °C, with induction period favoring 12–16 h (69.0%) over 3–6 h (14.3%). The statistical analyses highlight the correlation between protein properties and purification strategies. This tool is validated through two case studies: method bias for membrane protein purification, and crosslinker/detergent preferences for Cryo-Electron Microscopy sample preparation. These findings provide a valuable resource for designing protein expression and purification experiments.}, archive = {J_ADVS}, author = {Zhuojian Chen and J. Sivaraman}, doi = {10.1002/advs.202413689}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413689}, shortjournal = {Adv. Sci.}, title = {Using large language model to optimize protein purification: Insights from protein structure literature associated with protein data bank}, volume = {12}, year = {2025}, }
• (2025). 4D biofabrication of magnetically augmented callus assembloid implants enables rapid endochondral ossification via activation of mechanosensitive pathways. ADVS, 12(15), 2413680. (www)

  @article{ , abstract = {The use of magnetic-driven strategies for non-contact manipulation of engineered living modules opens up new possibilities for tissue engineering. The integration of magnetic nanoparticles (MNPs) with cartilaginous microtissues enables model-driven 4D bottom-up biofabrication of remotely actuated assembloids, providing unique properties to mechanoresponsive tissues, particularly skeletal constructs. However, for clinical use, the long-term effects of magnetic stimulation on phenotype and in vivo functionality need further exploration. Magnetic-driven biofabrication includes both rapid processes, such as guided microtissue assembly, and slower biological processes, like extracellular matrix secretion. This work explores the interplay between magnetic fields and MNP-loaded cartilaginous microtissues through mathematical modeling and experimental approaches, investigating long-term stimulation effects on ECM maturation and chondrogenic hypertrophy. Transcriptomic analysis reveal that magnetic stimulation activated mechanosensitive pathways and catabolic processes, driving accelerated cartilage-to-bone transitions via endochondral ossification, outcomes not observed in non-stimulated controls. This study paves the way for pre-programmed, remotely actuated skeletal assembloids with superior bone-forming capacity for regenerating challenging bone fractures.}, archive = {J_ADVS}, author = {Konstantinos Ioannidis and Andreas Dimopoulos and Isaak Decoene and Maya Guilliams and Hanna Svitina and Liudmyla Storozhuk and Rodrigo de Oliveira-Silva and Sergey Basov and Nguyen Thi Kim Thanh and Stefanos Mourdikoudis and Margriet J. Van Bael and Bart Smeets and Dimitrios Sakellariou and Ioannis Papantoniou}, doi = {10.1002/advs.202413680}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413680}, shortjournal = {Adv. Sci.}, title = {4D biofabrication of magnetically augmented callus assembloid implants enables rapid endochondral ossification via activation of mechanosensitive pathways}, volume = {12}, year = {2025}, }
• (2025). How do glycine-induced bent structures influence hierarchical nanostructuring and suprastructural handedness in short peptide assembly?. ADVS, 12(15), 2413602. (www)

  @article{ , abstract = {Despite the multiple roles of flexible and achiral Gly in regulating protein architectures and functions, its high flexibility is seldom exploited as a structural modulator in the design of self-assembling peptides. By using minimalistic peptide sequences, the effects of Gly insertions are investigated on the molecular conformation and the supramolecular morphology, focusing on Gly-induced bent structures and their impact on self-assembled nanostructures and handedness. Different backbone bending degrees are generated by varying Gly position, which in turn resulted in distinct hydrogen bonding modes and residue shifting upon dimerization, eventually leading to β -sheets and nanofibrils with opposite handedness. The bent structures are revealed to be primarily caused by van der Waals interactions between either the side chains themselves or the side chain and the local backbone around the inserted Gly, in sharp contrast to canonical β -turns stabilized by intrastrand hydrogen bonding. Hence, changing the side chain orientations of adjacent residues by chiral substitution can destabilize the bent structures, leading to wide ribbons with suprastructural chiral racemization. This study not only helps understand the versatile roles of Gly in protein architectures but also serves as a paradigm for tuning peptide supramolecular nanostructures and handedness via Gly insertion.}, archive = {J_ADVS}, author = {Xinfeng Ju and Kai Qi and Yan Wang and Limin Zhang and Yingyu Wang and Muhan Wang and Jiqian Wang and Jun Zhang and Jian R. Lu and Hai Xu and Yurong Zhao}, doi = {10.1002/advs.202413602}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413602}, shortjournal = {Adv. Sci.}, title = {How do glycine-induced bent structures influence hierarchical nanostructuring and suprastructural handedness in short peptide assembly?}, volume = {12}, year = {2025}, }
• (2025). (Apo)Lipoprotein profiling with multi-omics analysis identified medium-HDL-targeting PSRC1 with therapeutic potential for coronary artery disease. ADVS, 12(15), 2413491. (www)

  @article{ , abstract = {Identification of (apo)lipoprotein subclasses causally underpinning atherosclerosis may lead to identification of novel drug targets for treatment of atherosclerotic cardiovascular disease (ASCVD). In this study, observational and genetic associations between (apo)lipoprotein profile and carotid intima-media thickness-assessed atherosclerosis, and risks of coronary artery disease (CAD) and ischemic stroke (IS) are assessed, using data from the UK Biobank study, with further exploration of potential drug target for these two ASCVD subtypes through multi-omics analysis integrating genetic, transcriptomic, and proteomic data. Cholesteryl ester content in medium high-density lipoprotein causally protective of atherosclerosis is identified, plus a target gene, PSRC1 , with therapeutic potential for CAD, but not IS, supported by consistent evidence from multi-omics layers of data, which also reveals that such therapeutic potential may be through downregulation of circulating proteins including TRP1 , GRNs , and Pla2g12b , and upregulation of Neo1 . The results provide strong evidence as well as mechanistic clues of PSRC1 ’s therapeutic potential for CAD.}, archive = {J_ADVS}, author = {Yingmei Li and Sihan Wang and Ling Liu and Hao Cai and Yacan Huang and Mingjing Gao and Xiaogang Zhang and Qingqing Wu and Gaokun Qiu}, doi = {10.1002/advs.202413491}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413491}, shortjournal = {Adv. Sci.}, title = {(Apo)Lipoprotein profiling with multi-omics analysis identified medium-HDL-targeting PSRC1 with therapeutic potential for coronary artery disease}, volume = {12}, year = {2025}, }
• (2025). Improving CO oxidation catalysis over high entropy spinels by increasing disorder. ADVS, 12(15), 2413424. (www)

  @article{ , abstract = {Enhancing the activity and stability of earth-abundant, heterogeneous catalysts remains a key challenge, requiring new materials design strategies to replace platinum-group metals. Herein, it is demonstrated that increasing the configurational disorder of spinel metal oxides (M 3 O 4 , where M is a combination of Cr, Mn, Fe, Co, Ni, Cu, and Zn) leads to significant improvements in carbon monoxide (CO) oxidation performance. A substantial 63% decrease in the T 10 value (temperature to reach 10% CO oxidation) is observed by systematically increasing the number of first-row transition metals within the spinel oxide. Long-term stability studies reveal that the most disordered 7-metal spinel oxide exhibited superior resistance to catalyst deactivation compared to the 4-metal variant, showing a decrease in activity of only 4.7% versus 12.2% during 14 h of operation. A solventless thermolysis approach is developed to synthesize a series of medium entropy spinel oxide (MESO) and high entropy spinel oxides (HESOs) from discrete, air-stable molecular precursors. Comprehensive crystal structure determination, elemental distribution analysis, and surface characterization are conducted, establishing a clear structure-function relationship between elemental composition, configurational disorder, and catalytic performance. This work highlights how configurational disorder can serve as an effective design principle for developing both active and stable catalysts.}, archive = {J_ADVS}, author = {Joshua D. Swindell and Gareth R.M. Tainton and Sarayute Chansai and Kerry Hazeldine and Mark A. Buckingham and Alex S. Walton and Christopher Hardacre and Sarah J. Haigh and David J. Lewis}, doi = {10.1002/advs.202413424}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413424}, shortjournal = {Adv. Sci.}, title = {Improving CO oxidation catalysis over high entropy spinels by increasing disorder}, volume = {12}, year = {2025}, }
• (2025). The type III secretion system (T3SS) of escherichia coli promotes atherosclerosis in type 2 diabetes mellitus. ADVS, 12(15), 2413296. (www)

  @article{ , abstract = {Large-scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, a higher abundance of the type III secretion system (T3SS) virulence factors of Enterobacteriaceae / Escherichia - Shigella in patients with T2DM-related-ASCVD, which correlates with their atherosclerotic stenosis is reported. Overexpression of T3SS via Citrobacter rodentium (CR) infection in Apoe-/- T2DM mice exacerbated atherosclerotic lesion formation and increased gut permeability. Non-targeted metabolomic and proteomic analysis of mouse serum showed that T3SS caused abnormal glycerophospholipid metabolism in mice. Proteomics, RNA sequencing, and functional analyses showed that T3SS induced ferroptosis in intestinal epithelial cells, partly due to increased expression of ferritin heavy chains (FTH1). This findings first demonstrated that T3SS increases ferroptosis in intestinal epithelial cells, via disrupting the intestinal barrier and upregulation of phosphatidylcholine, thereby exacerbating T2DM-related ASCVD.}, archive = {J_ADVS}, author = {Yao-Yuan Zhang and Song-Tao Chen and Gang Chen and Le Zhou and Guo-Liang Zhou and Xin-Yuan Yu and Long Yuan and Wei-Qian Deng and Zhen-Bo Wang and Jing Li and Yi-Fu Tu and Da-Wei Zhang and Yuan li and Abdul Sammad and Xiao Zhu and Kai Yin}, doi = {10.1002/advs.202413296}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413296}, shortjournal = {Adv. Sci.}, title = {The type III secretion system (T3SS) of escherichia coli promotes atherosclerosis in type 2 diabetes mellitus}, volume = {12}, year = {2025}, }
• (2025). Multiscale dissection of spatial heterogeneity by integrating multi-slice spatial and single-cell transcriptomics. ADVS, 12(15), 2413124. (www)

  @article{ , abstract = {The spatial structure of cells is highly organized at multiscale levels from global spatial domains to local cell type heterogeneity. Existing methods for analyzing spatially resolved transcriptomics (SRT) are separately designed for either domain alignment across multiple slices or deconvoluting cell type compositions within a single slice. To this end, a novel deep learning method, SMILE, is proposed which combines graph contrastive autoencoder and multilayer perceptron with local constraints to learn multiscale and informative spot representations. By comparing SMILE with the state-of-the-art methods on simulation and real datasets, the superior performance of SMILE is demonstrated on spatial alignment, domain identification, and cell type deconvolution. The results show SMILE's capability not only in simultaneously dissecting spatial variations at different scales but also in unraveling altered cellular microenvironments in diseased conditions. Moreover, SMILE can utilize prior domain annotation information of one slice to further enhance the performance.}, archive = {J_ADVS}, author = {Yuqi Chen and Caiwei Zhen and Yuanyuan Mo and Juan Liu and Lihua Zhang}, doi = {10.1002/advs.202413124}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413124}, shortjournal = {Adv. Sci.}, title = {Multiscale dissection of spatial heterogeneity by integrating multi-slice spatial and single-cell transcriptomics}, volume = {12}, year = {2025}, }
• (2025). Squamocin suppresses tumor growth through triggering an endoplasmic reticulum stress-associated degradation of EZH2/MYC axis. ADVS, 12(15), 2413120. (www)

  @article{ , abstract = {Despite substantial advances in the antitumor effects of annonaceous acetogenins (ACGs), the absence of a defined biological action mechanism remains a major barrier to their clinical application. Here, it is found that squamocin effectively depletes both EZH2 and MYC in multiple cancer cell lines, including head and neck squamous cell carcinoma, and gastric and colorectal cancer, demonstrating potent efficacy in suppressing these in vivo tumor models. Through the combination of surface plasmon resonance (SPR), differential scanning fluorimetry (DSF), and cellular thermal shift assay (CETSA), heat shock protein 90α (HSP90α) is identified as the direct binding target of squamocin. Mechanistically, squamocin disrupts mitochondrial respiratory Complex I function, reduces ATP production, and impairs HSP90α function, provoking endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). These intrinsic events within tumor cells enhance ER stress-associated ubiquitylation and degradation by triggering ubiquitin via the E1 activase UBA6, facilitating ubiquitin transferring to E2 conjugate UBE2Z and increasing the activities of E3 ligase FBXW7 to degrade both EZH2 and MYC. The findings elucidate the role of squamocin in the degradation of oncoproteins EZH2 and MYC by triggering an ER stress-associated UBA6-UBE2Z-FBXW7 ubiquitin cascade, providing insights that may accelerate therapeutic development targeting tumors driven by the EZH2/MYC axis.}, archive = {J_ADVS}, author = {Yin Zhu and Yurui Liu and Xiangtao Wang and Zhifeng Chen and Baojian Chen and Bingxin Hu and Tiane Tang and Haoran Cheng and Xinglong Liu and Yunshan Ning}, doi = {10.1002/advs.202413120}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413120}, shortjournal = {Adv. Sci.}, title = {Squamocin suppresses tumor growth through triggering an endoplasmic reticulum stress-associated degradation of EZH2/MYC axis}, volume = {12}, year = {2025}, }
• (2025). 1000 fold ultra-photosensitized fluorescent protein mimics toward photocatalytic proximity labeling and proteomic profiling functions. ADVS, 12(15), 2413063. (www)

  @article{ , abstract = {Photosensitizing fluorescent proteins (FP) (e.g. KillerRed) have been shown not capable of photo-catalytic protein proximity labeling for downstream proteomic profiling applications. To acquire such a function, FP chromophores are engineered in a 12 × 12 combinatorial matrix of synthetic analoges, achieving up to 1000 fold enhancement of reactive oxygen species (ROS) production compared to the natural FPs. FP chromophores are shown with larger dipole moments exhibit higher ROS yield toward protein labeling. By conjugating the ultra-photosensitized FP chromophore to HaloTag (namely upsFP tag), its photo-catalytic protein proximity labeling function is demonstrated using nucleophilic amino substrates. Through photochemical characterizations, theoretical calculation, and tandem mass spectrometry, a radical-mediated labeling mechanism is revealed with expanded reactivity toward diverse protein residues via a type I photosensitization pathway. Finally, a proteomic profiling application is showcased using the upsFP tag to resolve the dynamic interactome variations upon TAR DNA-binding protein 43 (TDP43) phase separation and suborganellar translocation. Together, this work demonstrates three orders of magnitude ultra-photosensitization of fluorescent protein chromophore enables photocatalytic protein proximity labeling and profiling functions that are impractical for natural fluorescent proteins.}, archive = {J_ADVS}, author = {Rui Sun and Yanan Huang and Huan Feng and Nan Zhao and Wang Wan and Di Shen and Bowen Zhong and Yukui Zhang and Xin Zhang and Qun Zhao and Lihua Zhang and Yu Liu}, doi = {10.1002/advs.202413063}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2413063}, shortjournal = {Adv. Sci.}, title = {1000 fold ultra-photosensitized fluorescent protein mimics toward photocatalytic proximity labeling and proteomic profiling functions}, volume = {12}, year = {2025}, }
• (2025). Applying ultrasound to mechanically and noninvasively sensitize prostate tumors to TRAIL-mediated apoptosis. ADVS, 12(15), 2412995. (www)

  @article{ , abstract = {Non-surgical and safe prostate cancer (PCa) therapies are in demand. Soluble tumor necrosis factor (TNF-α) related apoptosis inducing ligand (TRAIL), a cancer-specific drug, shows preclinical efficacy but has a short circulation half-life. This research has shown that physiological fluid shear stress activates mechanosensitive ion channels (MSCs), such as Piezo1, enhancing TRAIL-mediated apoptosis in cancer cells. Herein, noninvasive, focal ultrasound (FUS) is implemented to augment the pro-apoptotic effects of TRAIL. Using thermally safe FUS parameters, it is observed that TRAIL sensitivity increases with higher FUS pressure in PCa cells, mediated by Piezo1. This is confirmed by examining the effects of calcium chelation, MSC inhibitors, and PIEZO knockdown. In vivo, a multi-dose study with 10 min FUS exposure shows that 0 and 4-h intervals between TRAIL and FUS significantly reduce tumor burden, with an increase in apoptosis evident by enhanced cleaved-caspase 3 expression. This mechanotherapy offers a clinically translatable approach by utilizing widely available FUS technology, applicable to treat additional cancer types.}, archive = {J_ADVS}, author = {Abigail R. Fabiano and Malachy W. Newman and Jenna A. Dombroski and Schyler J. Rowland and Samantha V. Knoblauch and Jiro Kusunose and Katherine N. Gibson-Corley and Benjamin G. Kaufman and Liqin Ren and Charles F. Caskey and Michael R. King}, doi = {10.1002/advs.202412995}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412995}, shortjournal = {Adv. Sci.}, title = {Applying ultrasound to mechanically and noninvasively sensitize prostate tumors to TRAIL-mediated apoptosis}, volume = {12}, year = {2025}, }
• (2025). Targeting histone deacetylase 11 with a highly selective inhibitor for the treatment of MASLD. ADVS, 12(15), 2412903. (www)

  @article{ , abstract = {Metabolic dysfunction-associated steatotic liver disease (MASLD) represents the most prevalent chronic liver disorder globally. Due to its intricate pathogenesis and the current lack of efficacious pharmacological interventions, there is a pressing need to discover novel therapeutic targets and agents for MASLD treatment. Herein, it is found that histone deacetylase 11 (HDAC11), a subtype of HDAC family, is markedly overexpressed in both in vitro and in vivo models of MASLD. Furthermore, the knockdown of HDAC11 is observed to mitigate lipid accumulation in hepatic cells. A highly selective HDAC11 inhibitor, B6 , which exhibits favorable pharmacokinetic property and liver distribution, is further designed and synthesized. Integrating RNA-seq data with in vivo and in vitro experiments, B6 is found to inhibit de novo lipogenesis (DNL) and promote fatty acid oxidation, thus mitigating hepatic lipid accumulation and pathological symptoms in MASLD mice. Further omics analysis and experiments reveal that B6 enhances the phosphorylation of AMPKα1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver. In summary, this study identifies HDAC11 as a potential therapeutic target in MASLD and reports the discovery of a highly selective HDAC11 inhibitor with favorable drug-like properties for the treatment of MASLD.}, archive = {J_ADVS}, author = {Feng Zhang and Kairui Yue and Simin Sun and Shengyuan Lu and Geng Jia and Yang Zha and Shuang Zhang and C. James Chou and Chenzhong Liao and Xiaoyang Li and Yajun Duan}, doi = {10.1002/advs.202412903}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412903}, shortjournal = {Adv. Sci.}, title = {Targeting histone deacetylase 11 with a highly selective inhibitor for the treatment of MASLD}, volume = {12}, year = {2025}, }
• (2025). CpG-based nanovaccines enhance ovarian cancer immune response by gbp2-mediated remodeling of tumor-associated macrophages. ADVS, 12(15), 2412881. (www)

  @article{ , abstract = {CpG oligodeoxynucleotides (CpG), as an immunoadjuvant, can facilitate the transformation of tumor-associated macrophages (TAMs)into tumoricidal M1 macrophages. However, the accumulation of free CpG in tumor tissues remains a substantial challenge. To address this, a nanovaccine (PLGA-CpG@ID8-M) is engineered by encapsulating CpG within PLGA using ID8 ovarian cancer cell membranes (ID8-M). This nanovaccine demonstrates remarkable efficacy in reprogramming TAMs in ovarian cancer and significantly extends survival in ID8-bearing mice. Notably, these findings indicate that the nanovaccine can also mitigate chemotherapy-induced immunosuppression by increasing the proportion of M1-like TAMs and reducing the expression of CD47 on tumor cells, thereby achieving a synergistic effect in tumor immunotherapy. Mechanistically, through transcriptome sequencing (RNA-seq), single-cell RNA sequencing (scRNA-seq), and mass spectrometry-based proteomics, it is elucidated that the nanovaccine enhances the expression of Gbp2 and promotes the recruitment of Pin1, which activates the NFκB signaling pathway, leading to the M1 polarization of TAMs. Furthermore, macrophages with elevated Gbp2 expression significantly inhibit tumor growth in both ID8 ovarian cancer and 4T1 breast cancer models. Conversely, targeting Gbp2 diminishes the antitumor efficacy of the nanovaccine in vivo. This study offers an innovative approach to immunotherapy and elucidates a novel mechanism (Gbp2-Pin1-NFκB pathway) for remodeling TAMs.}, archive = {J_ADVS}, author = {Jiaqiang Xiong and Juyuan Huang and Hanxiao Xu and Qiuji Wu and Jiahui Zhao and Yurou Chen and Guanlan Fan and Haotong Guan and Rourou Xiao and Zhaojin He and Siqi Wu and Wenliang Ouyang and Shixuan Wang and Lu Zhang and Peng Xia and Wei Zhang and Meng Wu}, doi = {10.1002/advs.202412881}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412881}, shortjournal = {Adv. Sci.}, title = {CpG-based nanovaccines enhance ovarian cancer immune response by gbp2-mediated remodeling of tumor-associated macrophages}, volume = {12}, year = {2025}, }
• (2025). Targeting USP1 potentiates radiation-induced type i IFN-dependent antitumor immunity by enhancing oligo-ubiquitinated SAR1A-mediated STING trafficking and activation. ADVS, 12(15), 2412687. (www)

  @article{ , abstract = {The magnitude of Type I interferon (IFN) mediated innate immune response within the tumor microenvironment (TME) critically influences the effectiveness of radiotherapy. Unfortunately, due to a myriad of resistance mechanisms, the double-stranded DNA (dsDNA) signals produced by tumor cells postradiotherapy often induce a diminished response from immune cells. Through chemical screening targeting deubiquitinating enzymes, we identified USP1 (Ubiquitin Specific Peptidase 1) inhibitor as an enhancer of post-radiotherapy dsDNA responses. Mechanistically, within the context of immune-stimulatory cells in TME, USP1 serves as a suppressor in the stress-mediated stages of the cGAS (Cyclic GMP-AMP synthase) -STING (Stimulator of interferon genes protein) signaling pathway, specifically affecting the trafficking of STING from endoplasmic reticulum to Golgi apparatus. It is elucidated that SAR1A (Secretion associated Ras related GTPase 1A) requires K27-linked oligo-ubiquitination to assemble the STING-COP-II (Coat protein II) transport complex for STING trafficking. USP1 counteracts this activation by removing SAR1A ubiquitination, thereby blocking STING trafficking and activation. Consequently, pharmacological USP1 inhibition using ML323 sustains SAR1A ubiquitination and COP-II complex formation, significantly enhancing STING trafficking and subsequent Type I IFN production. This intervention substantially amplifies radiotherapy-induced immune activation in the TME, providing a strategic approach to overcome therapeutic resistance and synergize radiotherapy with immunotherapies.}, archive = {J_ADVS}, author = {Weilin Zhou and Yuxuan Zhao and Wenjing Qin and Weijian Wu and Chenyang Liao and Yiqiu Zhang and Xingli Yang and Xue Chen and Youqiao Wang and Yushan Kang and Jiaxin Wu and Jiaojiao Zhao and Junmin Quan and Xuecen Wang and Xianzhang Bu and Xin Yue}, doi = {10.1002/advs.202412687}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412687}, shortjournal = {Adv. Sci.}, title = {Targeting USP1 potentiates radiation-induced type i IFN-dependent antitumor immunity by enhancing oligo-ubiquitinated SAR1A-mediated STING trafficking and activation}, volume = {12}, year = {2025}, }
• (2025). Lactylation-driven HECTD2 limits the response of hepatocellular carcinoma to lenvatinib. ADVS, 12(15), 2412559. (www)

  @article{ , abstract = {Drug resistance remains a major hurdle for the therapeutic efficacy of lenvatinib in hepatocellular carcinoma (HCC). However, the underlying mechanisms remain largely undetermined. Unbiased proteomic screening is performed to identify the potential regulators of lenvatinib resistance in HCC. Patient-derived organoids, patient-derived xenograft mouse models, and DEN/CCl 4 induced HCC models are constructed to evaluate the effects of HECTD2 both in vitro and in vivo. HECTD2 is found to be highly expressed in lenvatinib-resistant HCC cell lines, patient tissues, and patient-derived organoids and xenografts. In vitro and in vivo experiments demonstrated that overexpression of HECTD2 limits the response of HCC to lenvatinib treatment. Mechanistically, HECTD2 functions as an E3 ubiquitin ligase of KEAP1, which contributes to the degradation of KEAP1 protein. Subsequently, the KEAP1/NRF2 signaling pathway initiates the antioxidative response of HCC cells. Lactylation of histone 3 on lysine residue 18 facilitates the transcription of HECTD2. Notably, a PLGA-PEG nanoparticle-based drug delivery system is synthesized, effectively targeting HECTD2 in vivo. The NPs achieved tumor-targeting, controlled-release, and biocompatibility, making them a promising therapeutic strategy for mitigating lenvatinib resistance. This study identifies HECTD2 as a nanotherapeutic target for overcoming lenvatinib resistance, providing a theoretical basis and translational application for HCC treatment.}, archive = {J_ADVS}, author = {Runyu Dong and Yao Fei and Yiren He and Peng Gao and Bo Zhang and Menglin Zhu and Zhixiong Wang and Longfei Wu and Shuai Wu and Xiaoming Wang and Juan Cai and Zhiqiang Chen and Xueliang Zuo}, doi = {10.1002/advs.202412559}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412559}, shortjournal = {Adv. Sci.}, title = {Lactylation-driven HECTD2 limits the response of hepatocellular carcinoma to lenvatinib}, volume = {12}, year = {2025}, }
• (2025). Immunostimulatory hydrogel with synergistic blockage of glutamine metabolism and chemodynamic therapy for postoperative management of glioblastoma. ADVS, 12(15), 2412507. (www)

  @article{ , abstract = {Glioblastoma multiforme (GBM) is one of the most lethal malignant brain tumors in the central nervous system. Patients face many challenges after surgery, including tumor recurrence, intracranial pressure increase due to cavitation, and limitations associated with immediate postoperative oral chemotherapy. Here an injected peptide gel with in situ immunostimulatory functions is developed to coordinate the regulation of glutamine metabolism and chemodynamic therapy for overcoming these postoperative obstacles. The methodology entails crafting injectable gel scaffolds with short peptide molecules, incorporating the glutaminase inhibitor CB-839 and copper peptide self-assembled particles (Cu-His NPs) renowned for their chemodynamic therapy (CDT) efficacy. By fine-tuning glutamic acid production via metabolic pathways, this system not only heightens the therapeutic prowess of copper peptide particles in CDT but also escalates intracellular oxidative stress. This dual mechanism culminates in augmented immunogenic cell death within glioblastoma multiforme cells and improves a conducive immune microenvironment. Based on the concept of metabolic reprogramming, this treatment strategy has great potential to significantly reduce GBM tumor recurrence and prolong median survival in murine models.}, archive = {J_ADVS}, author = {Yiran Guo and Tianhe Jiang and Sen Liang and Anhe Wang and Jieling Li and Yi Jia and Qi Li and Jian Yin and Shuo Bai and Junbai Li}, doi = {10.1002/advs.202412507}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412507}, shortjournal = {Adv. Sci.}, title = {Immunostimulatory hydrogel with synergistic blockage of glutamine metabolism and chemodynamic therapy for postoperative management of glioblastoma}, volume = {12}, year = {2025}, }
• (2025). Regulation of liquid self-transport through architectural-thermal coupling: Transitioning from free surfaces to open channels. ADVS, 12(15), 2412483. (www)

  @article{ , abstract = {In this work, the regulation of liquid self-transport is achieved through architectural and thermal coupling, transitioning from free surfaces to open channels. Hierarchical structures inspired by the skin of a Texas horned lizard are designed, with the primary structure of wedged grooves and the secondary structure of capillary crura. This design enables advantages including long-distance self-transport, liquid storage and active reflux management on free surfaces, directional transportation, synthesis and detection of reagents in confined spaces, as well as controllable motion and enhanced heat dissipation in open channels. The regulation capacity can be precisely controlled by adjusting the secondary capillary crura and external thermal gradients. The regulation mechanism is further elucidated through microscopic flow observation and a deduced theoretical model. The proposed structures are expected to introduce a new concept for designing lubrication systems, microfluidic chips, methods for chemical synthesis, and heat transfer in the future.}, archive = {J_ADVS}, author = {Qingwen Dai and Chengxuan Du and Wei Huang and Xiaolei Wang}, doi = {10.1002/advs.202412483}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412483}, shortjournal = {Adv. Sci.}, title = {Regulation of liquid self-transport through architectural-thermal coupling: Transitioning from free surfaces to open channels}, volume = {12}, year = {2025}, }
• (2025). Siloxane decorated water-obstructing guest for efficient air-processed OSCs. ADVS, 12(15), 2412190. (www)

  @article{ , abstract = {The future applications of organic solar cells (OSCs) necessitate a thorough consideration of their ambient stability and processability, particularly for large area air-processed engineering, but water-induced degradation of active layer critically restricts its development. To surmount this hurdle, a water-obstructing guest (WOG) strategy is proposed to attenuate the interaction of the active layer with water molecules, reduce defects in blend films, and enhance the devices stability under high relative humidity (RH) conditions by introducing a siloxane-containing polymer D18-SiO. In addition to suppressing trap density, the WOG with hydrophobic and low surface free energy characteristics, forms a capping layer that blocks moisture penetration while preserving ideal nano-micromorphology with high crystallinity and tight packing properties. Power conversion efficiencies (PCE) of >19% is reported for spin coating OSCs fabricated across an RH range of 20 to 90%, and PCE of >17% blade coating OSCs at 90% RH. The D18-SiO, serves as a protective barrier to enhance the device stability, and the corresponding unencapsulated OSCs retained 80.7% of its initial performance in air (≈ 40% RH) after 600-h maximum power point tracking under continuous light illumination, showcasing great potential in designing WOG strategy for large-scale production of air-processed OSCs.}, archive = {J_ADVS}, author = {Yurong He and Wentao Miao and Tianyu Hu and Junchi Su and Aziz Saparbaev and Ming Wan and Jingnan Wu and Yuda Li and Huimin Xiang and Ergang Wang and Xunchang Wang and Renqiang Yang}, doi = {10.1002/advs.202412190}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412190}, shortjournal = {Adv. Sci.}, title = {Siloxane decorated water-obstructing guest for efficient air-processed OSCs}, volume = {12}, year = {2025}, }
• (2025). Stochastic photoresponse-driven perovskite TRNGs for secure encryption systems. ADVS, 12(15), 2412139. (www)

  @article{ , abstract = {True random numbers are essential for ensuring information security and supporting simulations across various industries. With the exponential growth of data driven by advancements in artificial intelligence, robust encryption for communications has become increasingly important. While software-based deterministic random number algorithms are cost-effective and easy to use, they are vulnerable to attacks by powerful supercomputers, highlighting the need for more secure alternatives. As portable electronic devices and information-gathering sensors proliferate, portable true random number generators (TRNGs) are critical for maintaining security. In this work, hybrid material-based photodetectors composed of anionic polymers and perovskites that maximize stochastic photogeneration for TRNG applications are presented. By integrating perovskite photodetectors with simple electronic circuits, compact, low-power TRNG devices have been developed that are versatile and resilient to environmental factors. These devices generate 10 000 bits s −1 without resets or delays, achieving significant miniaturization. The generated 10 Mbit random number is validated through US National Institute of Standards and Technology (NIST) testing. Using a 480 000-bit random sequence, perfect image encryption, ensuring protection against hacking are demonstrated. Additionally, the perovskite TRNG can operate under external light even when embedded in pork skin, realizing its potential as an implantable device for personal security and authentication.}, archive = {J_ADVS}, author = {Dante Ahn and Minz Lee and Woochul Kim and Yeon Kyung Lee and Jun Young Lee and Gun Young Jung and Hangyeol Choi and Yohan Yoon and Hyun Seok Song and Heon Lee and Minah Seo and Jungwook Min and Yusin Pak}, doi = {10.1002/advs.202412139}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412139}, shortjournal = {Adv. Sci.}, title = {Stochastic photoresponse-driven perovskite TRNGs for secure encryption systems}, volume = {12}, year = {2025}, }
• (2025). NAD+ metabolism reprogramming drives SIRT1-dependent deacetylation inducing PD-l1 nuclear localization in cervical cancer. ADVS, 12(15), 2412109. (www)

  @article{ , abstract = {Cervical cancer (CC) is a major health threat to women, with immunotherapies targeting the programmed death receptor 1/programmed death ligand 1(PD-1/PD-L1) axis showing promise but encountering resistance in a significant patient population. This resistance has driven a critical quest to uncover the underlying mechanisms. This study uncovers a novel metabolic axis involving the nicotinamide adenine dinucleotide (NAD + ) salvage pathway enzyme nicotinamide phosphoribosyltransferase (NAMPT) and the deacetylase Sirtuin 1 (SIRT1), which regulates PD-L1 expression and nuclear localization in CC. This axis may be a key factor contributing to the resistance observed in immunotherapy. This study reveals that PD-L1 overexpression in cancers is regulated by both transcriptional and post-transcriptional processes. Acetyl-proteomic analysis pinpoints SIRT1 as a central regulator in the deacetylation of histone H3 at lysines 27, which may influence PD-L1 subcellular distribution. This finding reveals the epigenetic control of immune checkpoint proteins by metabolic pathways, offering a new perspective on the regulation of PD-L1. The identification of the NAMPT/SIRT1 metabolic axis as a critical factor suggests that targeting this axis may enhance therapeutic responses.}, archive = {J_ADVS}, author = {Xinyi Lu and Pingping Jin and Qianyun Tang and Min Zhou and Hanjie Xu and Chen Su and Lei Wang and Feng Xu and Min Zhao and Yongxiang Yin and Jinqiu Zhang and Zhen Jia and Xinrui Peng and Jie Zhou and Lu Wang and Yan Chen and Min Wang and Min Yang and Daozhen Chen and Yu Chen}, doi = {10.1002/advs.202412109}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2412109}, shortjournal = {Adv. Sci.}, title = {NAD+ metabolism reprogramming drives SIRT1-dependent deacetylation inducing PD-l1 nuclear localization in cervical cancer}, volume = {12}, year = {2025}, }
• (2025). Optimization strategies and efficiency prediction for silicon solar cells with hybrid route of PERC and SHJ passivation contact. ADVS, 12(15), 2411965. (www)

  @article{ , abstract = {PERC solar cell technology, which emerged in the 1980s, has garnered a substantial portion of the PV market over the past decade. However, the main factors limiting their further efficiency advancements and wider commercialization lie in metal contact recombination and the passivation properties of the functional layers. Despite heterojunction cells demonstrating remarkable efficiency, challenges persist in terms of cost reduction and stability enhancement. This study introduces a novel hybrid solar cell architecture that integrates a diffusion-free front surface field with a high-quality heterojunction passivation contact. Through rigorous simulation analysis, it is revealed that the hybrid design surpasses conventional PERC in several key aspects: diminished front-surface recombination losses, enhanced rear-contact characteristics, and reduced grid shading. By strategically optimizing the front passivation and adopting single-side wet etching techniques, a PCE of 24.17% and V OC of 716 mV is successfully achieved on a full-size commercial czochralski silicon wafer (274.15 cm 2 ). Additionally, both experimental EQE tests and simulations delve into the composition of J SC gain during the optimization process. This comprehensive investigation not only offers an in-depth assessment of hybrid solar cell performance, but also outlines promising avenues for future optimization aimed at pushing theoretical efficiency limits further and enhancing suitability for large-scale production.}, archive = {J_ADVS}, author = {Zixiao Zhou and Qian Kang and Zhaoqing Sun and Yongcai He and Jingjie Li and Lu Wu and Chang Sun and Chaowei Xue and Minghao Qu and Xiaoqing Chen and Zilong Zheng and Bo Wang and Hui Yan and Xixiang Xu and Yongzhe Zhang}, doi = {10.1002/advs.202411965}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2411965}, shortjournal = {Adv. Sci.}, title = {Optimization strategies and efficiency prediction for silicon solar cells with hybrid route of PERC and SHJ passivation contact}, volume = {12}, year = {2025}, }
• (2025). N4-acetylcytidine-mediated CD2BP2-DT drives YBX1 phase separation to stabilize CDK1 and promote breast cancer progression. ADVS, 12(15), 2411834. (www)

  @article{ , abstract = {Long noncoding RNAs (lncRNAs) play critical roles in the initiation and progression of breast cancer. However, the specific mechanisms and biological functions of lncRNAs in breast cancer remain incompletely understood. Bioinformatics analysis identifies a novel lncRNA, CD2BP2-DT, that is overexpressed in breast cancer and correlates with adverse clinicopathological features and poor overall survival. Both in vivo and in vitro experiments demonstrate that CD2BP2-DT promotes proliferation of breast cancer cells. Mechanistically, NAT10 mediates the N4-acetylcytidine (ac4C) modification of CD2BP2-DT, enhancing its RNA stability and expression. More importantly, CD2BP2-DT enhances the stability of CDK1 mRNA by mediating YBX1 phase separation, thereby promoting the proliferation of breast cancer cells. In conclusion, the lncRNA CD2BP2-DT is identified as a crucial driver of breast cancer cell proliferation through the YBX1/CDK1 axis, highlighting its potential as a promising biomarker and therapeutic target for breast cancer.}, archive = {J_ADVS}, author = {Hongyu Wang and Bozhi Zhao and Jiayu Zhang and Qunyu Hu and Linlin Zhou and Yinghui Zhang and Yixin Cai and Yuansong Qu and Tao Jiang and Dongwei Zhang}, doi = {10.1002/advs.202411834}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2411834}, shortjournal = {Adv. Sci.}, title = {N4-acetylcytidine-mediated CD2BP2-DT drives YBX1 phase separation to stabilize CDK1 and promote breast cancer progression}, volume = {12}, year = {2025}, }
• (2025). Targeting the adenosine-mediated metabolic immune checkpoint with engineered probiotic for enhanced chemo-immunotherapy. ADVS, 12(15), 2411813. (www)

  @article{ , abstract = {Immunotherapy has revolutionized cancer treatment by leveraging the patient's immune system, yet its efficacy is often hampered by the immunosuppressive tumor microenvironment (TME). Adenosine, a key player in this milieu, suppresses immune cell activity via cAMP signaling. Here, an innovative strategy to remodel the TME using a genetically engineered strain of Escherichia coli Nissle 1917 that expresses adenosine deaminase on its surface under hypoxic conditions is presented. This engineered probiotic targets tumors, converts immunosuppressive adenosine to inosine, and enhances anti-tumor immune responses. In vivo, the engineered probiotic significantly improved immune cell infiltration and demonstrated synergistic effects with low-dose doxorubicin in both subcutaneous and orthotopic mouse colorectal cancer model. Furthermore, the engineered probiotic modulated the TME, promoting a shift from M2-like to M1-like macrophages and increasing effector T cell populations. These findings highlight the potential of using engineered probiotics for metabolic modulation of the TME, offering a novel approach for enhancing cancer immunotherapy.}, archive = {J_ADVS}, author = {Jinhui Wang and Jing Wang and Zhijie Yu and Hongyu Wen and Chensi Zhao and Jiayong Zhong and Chuanle Xiao and Yingqiu Li and Jianqiao Xu and Jinquan Wang and Zong-Wan Mao and Wei Xia}, doi = {10.1002/advs.202411813}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2411813}, shortjournal = {Adv. Sci.}, title = {Targeting the adenosine-mediated metabolic immune checkpoint with engineered probiotic for enhanced chemo-immunotherapy}, volume = {12}, year = {2025}, }
• (2025). NIR-II emissive persistent neutral π-radical with rapid doublet internal conversion for efficient cancer photothermal theranostics. ADVS, 12(15), 2411733. (www)

  @article{ , abstract = {Organic radicals are considered prospective materials for near-infrared (NIR) photothermal applications, however, sustainability remains the major obstacle of recently reported ionic radical photothermal agents. This work achieved robust sustainability on a series of neutral π-radicals through rational design donor (D)–acceptor (A). With efficient doublet internal conversion, 10H-spiro(acridine-9,9′-fluorene) (SFA)-BTM presented strong NIR absorption extended to 1000 nm and efficient non-radiative relaxation. SFA-BTM nanoparticles (NPs) realized comparable NIR-I photothermal conversion efficiency (PCE) and photoacoustic sensitivity. Also, the π-radical NPs displayed NIR-II emission and achieved high-resolution whole-body angiography for the first time by the NIR-II bioimaging. Ultimately, the photothermal capabilities are confirmed in an orthotopic bone tumor model by effective ablation of cancer cells in vitro and inhibition of the deterioration of tumor in vivo. This research offers a new horizon in the conception and development of sustainable organic radicals for effective NIR-II imaging and theranostics applications.}, archive = {J_ADVS}, author = {Qi Zhao and Chunxiao Wu and Yijian Gao and Jing Long and Wei Zhang and Yanan Chen and Yuliang Yang and Yu Luo and Yuxiao Lai and Houyu Zhang and Xiankai Chen and Feng Li and Shengliang Li}, doi = {10.1002/advs.202411733}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2411733}, shortjournal = {Adv. Sci.}, title = {NIR-II emissive persistent neutral π-radical with rapid doublet internal conversion for efficient cancer photothermal theranostics}, volume = {12}, year = {2025}, }
• (2025). Synthetic lethality of SHP2 and XIAP suppresses proliferation and metastasis in KRAS-mutant nonsmall cell lung cancer. ADVS, 12(15), 2411642. (www)

  @article{ , abstract = {Kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutations are associated with poor prognosis and poor response to standard therapeutic regimens in patients with nonsmall cell lung cancer (NSCLC). Identification of novel synthetic lethal partners in oncogenic KRAS is an alternative therapeutic strategy for KRAS -mutant malignancies. After high-throughput screening against a preclinical/clinical compound library, embelin, a known X-linked inhibitor of apoptosis protein (XIAP) inhibitor, specifically inhibits the catalytic activity and phosphorylation of Src homology domain 2 containing tyrosine phosphatase 2 (SHP2) in KRAS -mutant NSCLC cells. Pharmacological inhibition and genetic knockdown of XIAP and SHP2 induce synthetic lethality in KRAS -mutated NSCLC cells and xenograft animal models. Mechanistically, dual inhibition of XIAP and SHP2 by embelin lessens the proliferation and metastasis, activates senescence and endogenous apoptosis, inhibits cancer-related RAS/mitogen-activated protein kinase (MAPK), phosphoinositide-3-kinase (PI3K)/AKT, Janus kinase/signal transducers and activators of transcription (JAK/STAT), wingless-related integration site (Wnt), and nuclear factor kappa B (NF-κB) signaling pathways, and overcomes compensatory feedback in the MAPK signals through the modulation of mitogen-inducible gene-6 (MIG-6) and SPROUTY2 (SPRY2). Collectively, SHP2 and XIAP are potential synthetic lethal partners, and embelin warrants further development as a novel therapeutic option for alleviating KRAS -mutant NSCLC by cotargeting SHP2 and XIAP.}, archive = {J_ADVS}, author = {Nai-jie Fu and Yu-wen Sheng and Zhe Fan and Zhao Wu and Ling-yu Li and Rui-ying Xi and Xiao-ke Shi and Guo-lin Zhang and Fei Wang}, doi = {10.1002/advs.202411642}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2411642}, shortjournal = {Adv. Sci.}, title = {Synthetic lethality of SHP2 and XIAP suppresses proliferation and metastasis in KRAS-mutant nonsmall cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). Self-adaptive quantum kernel principal component analysis for compact readout of chemiresistive sensor arrays. ADVS, 12(15), 2411573. (www)

  @article{ , abstract = {The rapid growth of Internet of Things (IoT) devices necessitates efficient data compression techniques to manage the vast amounts of data they generate. Chemiresistive sensor arrays (CSAs), a simple yet essential component in IoT systems, produce large datasets due to their simultaneous multi-sensor operations. Classical principal component analysis (cPCA), a widely used solution for dimensionality reduction, often struggles to preserve critical information in complex datasets. In this study, the self-adaptive quantum kernel (SAQK) PCA is introduced as a complementary approach to enhance information retention. The results show that SAQK PCA outperforms cPCA in various back end machine-learning tasks, particularly in low-dimensional scenarios where quantum bit resources are constrained. Although the overall improvement is modest in some cases, SAQK PCA proves especially effective in preserving group structures within low-dimensional data. These findings underscore the potential of noisy intermediate-scale quantum (NISQ) computers to transform data processing in real-world IoT applications by improving the efficiency and reliability of CSA data compression and readout, despite current qubit limitations.}, archive = {J_ADVS}, author = {Zeheng Wang and Timothy van der Laan and Muhammad Usman}, doi = {10.1002/advs.202411573}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2411573}, shortjournal = {Adv. Sci.}, title = {Self-adaptive quantum kernel principal component analysis for compact readout of chemiresistive sensor arrays}, volume = {12}, year = {2025}, }
• (2025). Pepticombisomes: Biomimetic vesicles crafted from recombinant supercharged polypeptides with uniformly distributed side-chains. ADVS, 12(15), 2411497. (www)

  @article{ , abstract = {Cell membranes play a key role in bottom-up synthetic biology, as they enable interaction control, transport, and other essential functions. These ultra-thin, flexible, yet stable structures form through the self-assembly of lipids and proteins. While liposomes are common mimics, their synthetic membranes often fail to replicate natural properties due to poor structural control. To address this, pepticombs are introduced, a new family of supramolecular building blocks. They are synthesized by regularly appending anionic surfactants with lipid-long alkyl tails to cationic amino acid residues of recombinant elastin-like supercharged unfolded polypeptides (SUPs). Using microscopy techniques and molecular dynamics simulations, the formation of giant unilamellar vesicles, termed pepticombisomes, is demonstrated and their membrane properties are characterized. The molecular topology of pepticombs allows for precise mimicry of membrane thickness and flexibility, beyond classic polymersomes. Unlike the previously introduced ionically-linked comb polymers, all pepticombs exhibit a uniform degree of polymerization, composition, sequence, and spontaneous curvature. This uniformity ensures consistent hydrophobic tail distribution, facilitating intermolecular hydrogen bonding within the backbone. This generates elastic heterogeneities and the concomitant formation of non-icosahedral faceted vesicles, as previously predicted. Additionally, pepticombisomes can incorporate functional lipids, enhancing design flexibility.}, archive = {J_ADVS}, author = {Dominik Söder and Melina Schadt and Vladislav S. Petrovskii and Tamás Haraszti and Khosrow Rahimi and Igor I. Potemkin and Nina Yu. Kostina and Cesar Rodriguez-Emmenegger and Andreas Herrmann}, doi = {10.1002/advs.202411497}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2411497}, shortjournal = {Adv. Sci.}, title = {Pepticombisomes: Biomimetic vesicles crafted from recombinant supercharged polypeptides with uniformly distributed side-chains}, volume = {12}, year = {2025}, }
• (2025). Multimodal artificial intelligence-based virtual biopsy for diagnosing abdominal lavage cytology-positive gastric cancer. ADVS, 12(15), 2411490. (www)

  @article{ , abstract = {Gastric cancer with peritoneal dissemination remains a significant clinical challenge due to its poor prognosis and difficulty in early detection. This study introduces a multimodal artificial intelligence-based risk stratification assessment (RSA) model, integrating radiomic and clinical data to predict peritoneal lavage cytology-positive (GC-CY1) in gastric cancer patients. The RSA model is trained and validated across retrospective, external, and prospective cohorts. In the training cohort, the RSA model achieved an area under the curve (AUC) of 0.866, outperforming traditional clinical and radiomic feature models. External validation cohorts confirmed its robustness, with AUC values of 0.883 and 0.823 for predicting peritoneal metastasis and recurrence, respectively. In a prospective validation involving 152 patients, the model maintained superior predictive performance (AUC = 0.835). The RSA model also demonstrated significant clinical benefits by effectively identifying high-risk patients likely to benefit from specific treatments, such as paclitaxel-based conversion therapy. These findings suggest that the RSA model offers a reliable, non-invasive diagnostic tool for gastric cancer, capable of improving early detection and treatment outcomes. Further prospective studies are warranted to explore its full clinical potential.}, archive = {J_ADVS}, author = {Ping'an Ding and Jiaxuan Yang and Honghai Guo and Jiaxiang Wu and Haotian Wu and Tongkun Li and Renjun Gu and Lilong Zhang and Jinchen He and Peigang Yang and Yuan Tian and Ning Meng and Xiaolong Li and Zhenjiang Guo and Lingjiao Meng and Qun Zhao}, doi = {10.1002/advs.202411490}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2411490}, shortjournal = {Adv. Sci.}, title = {Multimodal artificial intelligence-based virtual biopsy for diagnosing abdominal lavage cytology-positive gastric cancer}, volume = {12}, year = {2025}, }
• (2025). A novel gene synthesis platform for designing functional protein polymers. ADVS, 12(15), 2410903. (www)

  @article{ , abstract = {Recombinant protein polymers with repeat sequences of specific amino acids can be regarded as sustainable functional materials that can be designed using genetic engineering. However, synthesizing genes encoding these proteins is significantly time-consuming and labor-intensive owing to the difficulty of using common gene synthesis tools, such as restriction enzymes and PCR primers. To overcome these obstacles, a novel method is proposed herein: seamless cloning of rolling-circle amplicons (SCRCA). This method involves one-pot preparation of repetitive-sequence genes with overlapping ends for cloning, facilitating the easy construction of the desired recombinants. SCRCA is used to synthesize 10 genes encoding hydrophilic resilin-like and hydrophobic elastin-like repeat units that induce liquid-liquid phase separation. SCRCA shows higher transformation efficiency and better workability than conventional methods, and the time and budget required for SCRCA are comparable to those required for non-repetitive-sequence gene synthesis. Additionally, SCRCA facilitates the construction of a repeat unit library at a low cost. The library shows considerably higher diversity than that of the current state-of-the-art method. By combining this library construction with the directed evolution concept, an elastin-like protein polymer with the desired functions can be rapidly developed. SCRCA can greatly accelerate research on protein polymers.}, archive = {J_ADVS}, author = {Toshimasa Homma and Rie Yamamoto and Lily Zuin Ping Ang and Alaa Fehaid and Mitsuhiro Ebara}, doi = {10.1002/advs.202410903}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2410903}, shortjournal = {Adv. Sci.}, title = {A novel gene synthesis platform for designing functional protein polymers}, volume = {12}, year = {2025}, }
• (2025). Modular calcium-responsive and CD9-targeted phospholipase system enhancing endosomal escape for DNA delivery. ADVS, 12(15), 2410815. (www)

  @article{ , abstract = {Gene delivery systems must overcome multiple barriers, with endosomal escape representing a prominent obstacle. We have previously shown that a bacterial phospholipase C (PLC) enabled endosomal escape of a non-viral protein-based DNA delivery system termed TFAMoplex. Building upon this, this work introduces a calcium-responsive system designed to enhance endosomal escape through non-covalent capturing of PLC to the TFAMoplex followed by its release within endosomes and nanobody-mediated targeting to the endosomal membrane. This approach leads to improved TFAMoplexes enabling transfection of HeLa cells in full serum with a half maximal effective concentration (EC 50 ) of less than 200 ng DNA per mL serum, using only 5 nM PLC. Particularly, the modular capture, release and targeting system could potentially be adapted to other delivery agents previously constrained by poor endosomal escape. These findings present a promising strategy to achieve efficient endosomal escape, offering prospects for improved delivery of macromolecules, in particular nucleic acids.}, archive = {J_ADVS}, author = {Alexander Klipp and Christina Greitens and David Scherer and Alexander Elsener and Jean-Christophe Leroux and Michael Burger}, doi = {10.1002/advs.202410815}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2410815}, shortjournal = {Adv. Sci.}, title = {Modular calcium-responsive and CD9-targeted phospholipase system enhancing endosomal escape for DNA delivery}, volume = {12}, year = {2025}, }
• (2025). X-linked gene dosage and SOX2 act as key roadblocks for human germ cell specification in klinefelter syndrome. ADVS, 12(15), 2410533. (www)

  @article{ , abstract = {Klinefelter syndrome (KS), characterized by the presence of at least one extra X-chromosome, is a common cause of male infertility. However, the mechanism underlying the failure of germline specification is not well studied. Intriguingly, the differentiation efficiency of female human pluripotent stem cells (hPSCs) is often lower than that of male. This study investigates how X-linked gene dosage affects human primordial germ cell-like cells (hPGCLCs) specification in both healthy and diseased conditions. This work reveals that X-linked genes play a multifaceted role against the fate competency to hPGCLCs, with escape genes IGSF1 and CHRDL1 inhibiting the TGF-beta/Activin A and BMP pathways, respectively. Notably, this work identifies a previously unrecognized role of SOX2, upregulated by the escape gene USP9X, elucidating a species-specific function in the mammalian germline. The USP9X-SOX2 regulatory axis profoundly influenced cellular metabolism, mitochondrial morphology, and progenitor competence in hPGCLCs specification. Furthermore, the inability to downregulate SOX2 and upregulate SOX17 in response to BMP signaling impedes downstream gene activation due to motif binding competition. These findings shed novel insights into the human germline specification by elucidating the divergent roles of SOX2 versus SOX17 in mammals, influenced by X-linked gene dosage effects. These results offer potential applications for improving the induction efficiency of hPGCLCs, facilitating disease mechanistic studies.}, archive = {J_ADVS}, author = {Wenteng He and Qing Luo and Jian Zhao and Mengting Wang and Allan Zhao and Luohua Feng and Ahmed Reda and Eva Lindgren and Jan-Bernd Stukenborg and Jiayu Chen and Qiaolin Deng}, doi = {10.1002/advs.202410533}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2410533}, shortjournal = {Adv. Sci.}, title = {X-linked gene dosage and SOX2 act as key roadblocks for human germ cell specification in klinefelter syndrome}, volume = {12}, year = {2025}, }
• (2025). Gaseous synergistic self-assembly and arraying to develop bio-organic photocapacitors for neural photostimulation. ADVS, 12(15), 2410471. (www)

  @article{ , abstract = {Bioinspired supramolecular architectonics is attracting increasing interest due to their flexible organization and multifunctionality. However, state-of-the-art bioinspired architectonics generally take place in solvent-based circumstance, thus leading to achieving precise control over the self-assembly remains challenging. Moreover, the intrinsic difficulty of ordering the bio-organic self-assemblies into stable large-scale arrays in the liquid environment for engineering devices severely restricts their extensive applications. Herein, a gaseous organization strategy is proposed with the physical vapor deposition (PVD) technology, allowing the bio-organic monomers not only self-assemble into architectures well-established from the solvent-based approaches but morphologies distinct from those delivered from the liquid cases. Specifically, 9-fluorenylmethyloxycarbonyl-phenylalanine-phenylalanine (Fmoc-FF) self-assembles into spheres with tailored dimensions in the gaseous environment rather than conventional nanofibers, due to the distinct organization mechanisms. Arraying of the spherical architectures can integrate their behaviors, thus endorsing the bio-organic film the ability of programmable optoelectronic properties, which can be employed to design P-N heterojunction-based bio-photocapacitors for non-invasive and nongenetic neurostimulations. The findings demonstrate that the gaseous strategy may offer an alternative approach to achieve unprecedented bio-organic superstructures, and allow ordering into large-scale arrays for behavior integration, potentially paving the avenue of developing supramolecular devices and promoting the practical applications of bio-organic architectonics.}, archive = {J_ADVS}, author = {Xinyuan Fan and Yiming Tang and Jiahao Zhang and Kang Ma and Zhengyu Xu and Yuying Liu and Bin Xue and Yi Cao and Deqing Mei and Wei Wang and Guanghong Wei and Kai Tao}, doi = {10.1002/advs.202410471}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2410471}, shortjournal = {Adv. Sci.}, title = {Gaseous synergistic self-assembly and arraying to develop bio-organic photocapacitors for neural photostimulation}, volume = {12}, year = {2025}, }
• (2025). An anti-CD147 Antibody−Drug conjugate mehozumab-DM1 is efficacious against hepatocellular carcinoma in cynomolgus monkey. ADVS, 12(15), 2410438. (www)

  @article{ , abstract = {Effective treatment strategies are urgently needed for hepatocellular carcinoma (HCC) patients due to frequent therapeutic resistance and recurrence. Antibody-drug conjugate (ADC) is a specific antibody-drug conjugated with small molecular compounds, which has potent killing activity against cancer cells. However, few ADC candidates for HCC are undergoing clinical evaluation. CD147 is a tumor-associated antigen that is highly expressed on the surface of tumor cells. Here CD147 is found significantly upregulated in tumor tissues of HCC. Mehozumab-DM1, a humanized anti-CD147 monoclonal antibody conjugated with Mertansine (DM1) is developed. Mehozumab-DM1 is effectively internalized by cancer cells and demonstrated potent antitumor efficacy in HCC cells. In vivo evaluation of Mehozumab-DM1 is conducted in a CRISPR-mediated PTEN and TP53 mutation cynomolgus monkey liver cancer model, which is poorly responsive to sorafenib treatment. Mehozumab-DM1 demonstrated potent tumor inhibitory efficacy at doses of 0.2 and 1.0 mg kg −1 treatment groups in cynomolgus monkey. No treatment-related adverse reactions or body weight loss are observed. Interestingly, Mehozumab-DM1 treatment induced RIPK-dependent tumor cell necroptosis through inhibiting IκB kinase/NF-κB pathway. In conclusion, Mehozumab-DM1 potently inhibits hepatoma through effective internalization to release payload and inducing cell necroptosis to enhance the bystander effect, which is a promising treatment for refractory HCC.}, archive = {J_ADVS}, author = {Wan Huang and Liping Zhong and Ying Shi and Qingzhi Ma and Xiangmin Yang and Hongmei Zhang and Jing Zhang and Ling Wang and Kun Wang and Jingzhuo Li and Jie Zou and Xu Yang and Liu Yang and Qingmei Zeng and Lin Jing and Zhi-Nan Chen and Yongxiang Zhao}, doi = {10.1002/advs.202410438}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2410438}, shortjournal = {Adv. Sci.}, title = {An anti-CD147 Antibody−Drug conjugate mehozumab-DM1 is efficacious against hepatocellular carcinoma in cynomolgus monkey}, volume = {12}, year = {2025}, }
• (2025). Self-powered frequency-selective acoustic sensor based on bound states in the continuum. ADVS, 12(15), 2410379. (www)

  @article{ , abstract = {Sound is a clean, renewable, and abundant energy source present ubiquitously in nature. However, it is often underutilized due to its low energy density in most environments. This study introduces a two-state system that supports a Friedrich–Wintgen bound state in the continuum (BIC), achieving an unprecedented enhancement in sound energy density—up to 1849 times the incident sound intensity. By integrating this BIC-supporting system with energy conversion mechanisms, such as piezoelectric films, high-performance acoustic energy harvesting and sensing is realized. As a proof-of-concept, a self-powered acoustic sensor system is developed. This sensor leverages the high-quality-factor nature of a BIC, providing exceptional passive frequency selectivity and the ability to activate a light-emitting diode (LED) at the target frequency of 501 Hz with an offset of only 4 Hz. This work represents a groundbreaking advancement in sound-energy enhancement, paving the way for BIC-induced acoustic harvesters and sensors, with promising applications in wireless sensor networks and the Internet of Things.}, archive = {J_ADVS}, author = {Chao Song and Sibo Huang and Hongyu Ma and Shuhuan Xie and Din Ping Tsai and Jie Zhu and Yong Li}, doi = {10.1002/advs.202410379}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2410379}, shortjournal = {Adv. Sci.}, title = {Self-powered frequency-selective acoustic sensor based on bound states in the continuum}, volume = {12}, year = {2025}, }
• (2025). NAT10 promotes gastric cancer liver metastasis by modulation of m2 macrophage polarization and metastatic tumor cell hepatic adhesion. ADVS, 12(15), 2410263. (www)

  @article{ , abstract = {The relationship between patterns of RNA modifications and gastric cancer (GC) liver metastasis (GCLM) remains unclear. Here, by single-cell sequencing, clinical sample analysis, and mouse model studies, an abnormal increase in the expression of the RNA acetyltransferase N-acetyltransferase 10 (NAT10) in liver metastatic GC cells is identified. NAT10-mediated N4-acetylcytidine modification of CXCL2 and KLF5 mRNA increases their stability. Then, secreted CXCL2 is found to promote the infiltration and polarization of M2-like macrophages to produce oncostatin M, which transcriptionally activates NAT10 expression via STAT3 signaling. In addition, organoid models confirm that NAT10 promotes the adhesion of GC cells to hepatocytes. Mechanistically, KLF5 transcriptionally activates ITGαV, facilitating GC cell attachment to hepatocytes. Intriguingly, high expression of NAT10/KLF5 axis is associated with poor prognosis of GC patients and targeting this axis significantly reduces GCLM in preclinical murine models. Collectively, these findings suggest the clinical significance of NAT10 in developing targeted therapies for GC patients with liver metastasis.}, archive = {J_ADVS}, author = {Chen Chen and Zhangding Wang and Qingfeng Lin and Mengmeng Li and Lei Xu and Yao Fu and Xiaoya Zhao and Zhuang Ma and Jiawen Xu and Shimeng Zhou and Mingyue Zhang and Yun Qian and Linsen Bao and Bo Wang and Meng Wang and Qingqing Ding and Qiang Wang and Shouyu Wang}, doi = {10.1002/advs.202410263}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2410263}, shortjournal = {Adv. Sci.}, title = {NAT10 promotes gastric cancer liver metastasis by modulation of m2 macrophage polarization and metastatic tumor cell hepatic adhesion}, volume = {12}, year = {2025}, }
• (2025). 3-D sustained-release culture carrier alleviates rat intervertebral disc degeneration by targeting STING in transplanted skeletal stem cells. ADVS, 12(15), 2410151. (www)

  @article{ , abstract = {The hypoxic and high-pressure microenvironment of the intervertebral discs poses a major challenge to the survival and therapeutic efficiency of exogenous stem cells. Therefore, improving the utilization efficiency and therapeutic effect of exogenous stem cells to delay intervertebral disc degeneration (IVDD) is of great importance. Here, hypoxic induction studies are conducted in vivo and in vitro using rat costal cartilage-derived skeletal stem cells (SSCs) and find that hypoxia activates the cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway and increased reactive oxygen species (ROS) accumulation, triggering ferroptosis in SSCs through hypoxia-inducible factor-1 alpha-dependent mitophagy. Progressive hypoxia preconditioning reduce STING expression and ROS accumulation, inducing SSCs differentiation into nucleus pulposus-like cells via the Wnt signaling pathway. Considering this, a 3-D sustained-release culture carrier is generated by mixing SSCs with methacrylated hyaluronic acid and polydopamine nanoparticles coated with the STING inhibitor C-176 and evaluated its inhibitory effect on IVDD. This carrier is demonstrated to inhibit the cGAS/STING pathway and prevent ROS accumulation by continuously releasing C-176-coated polydopamine nanoparticles, thereby reducing ferroptosis, promoting differentiation, and ultimately attenuating IVDD, suggesting its potential as a novel treatment strategy.}, archive = {J_ADVS}, author = {Liwen Luo and Shiyu Zhang and Junfeng Gong and Ji Zhang and Peng Xie and Jun Yin and MengJie Zhang and Cong Zhang and Hong Chen and Yao Liu and Bing Ni and Changqing Li and Zhiqiang Tian}, doi = {10.1002/advs.202410151}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2410151}, shortjournal = {Adv. Sci.}, title = {3-D sustained-release culture carrier alleviates rat intervertebral disc degeneration by targeting STING in transplanted skeletal stem cells}, volume = {12}, year = {2025}, }
• (2025). Colloidal perovskite nanocrystals for blue-light-emitting diodes and displays. ADVS, 12(15), 2409736. (www)

  @article{ , abstract = {The evolution of display technology toward ultrahigh resolution, high color purity, and cost-effectiveness has generated interest in metal halide perovskites, particularly colloidal perovskite nanocrystals (PeNCs). PeNCs exhibit narrow emission spectra, high photoluminescence quantum yields, and wide color gamuts, rendering them promising candidates for next-generation displays. Despite significant advancements in perovskite light-emitting diode (PeLED) technology, challenges remain regarding the efficiencies of PeNC-based blue LEDs. Addressing these challenges, including both inherent and external instabilities of PeNCs and operational instabilities of the devices, is important as they collectively impede the broader acceptance and utilization of PeNCs. Herein, a comprehensive overview of the syntheses of dimension- and composition-controlled blue colloidal PeNCs and critical factors influencing the performances of colloidal PeNC-based blue LEDs is provided. Moreover, the advancements of colloidal PeNC-based blue LEDs and challenges associated with the application of these LEDs are explored, and the potentials of these LEDs for application in next-generation displays are emphasized. This review highlights the path forward for the future development of PeNC-based blue LEDs.}, archive = {J_ADVS}, author = {Md Aftabuzzaman and Yongju Hong and Sangyeon Jeong and Ratiani Levan and Seung Jin Lee and Dong Hoon Choi and Kwangyeol Lee}, doi = {10.1002/advs.202409736}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2409736}, shortjournal = {Adv. Sci.}, title = {Colloidal perovskite nanocrystals for blue-light-emitting diodes and displays}, volume = {12}, year = {2025}, }
• (2025). Oral microalgae-based biosystem to enhance irreversible electroporation immunotherapy in hepatocellular carcinoma. ADVS, 12(15), 2409381. (www)

  @article{ , abstract = {Irreversible electroporation (IRE) is a novel local tumor ablation technique that can potentially stimulate immune responses. However, IRE alone cannot effectively activate the immune system or prevent distant metastases. Therefore, this study utilized the biocompatibility of Chlorella vulgaris ( C. vulgaris ) and polydopamine (PDA) adhesive properties to encapsulate a PD-1 inhibitor (PI). The PDA coating protects the drug from degradation by stomach acid and enhances its intestinal absorption. This carrier demonstrates excellent in vivo drug release control and biodistribution, significantly increasing the oral bioavailability of PI. Combining IRE with this natural carrier significantly improves the therapeutic efficacy, which increases the local drug concentration and activates the immune system. This system demonstrates significantly improved therapeutic efficacy against local tumors compared with PI or IRE alone and significantly reduces PI-associated side effects. A convenient oral delivery system is developed using this readily available natural micro-carrier that not only improves the therapeutic effect of IRE but also mitigates its adverse effects, indicating significant potential for clinical applications. This discovery offers a new strategy for hepatocellular carcinoma treatment with the potential to improve patient outcomes.}, archive = {J_ADVS}, author = {Cheng Zeng and Shiyuan Hua and Jiayu Zhou and Tangye Zeng and Jianke Chen and Lijian Su and Angfeng Jiang and Min Zhou and Zhe Tang}, doi = {10.1002/advs.202409381}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2409381}, shortjournal = {Adv. Sci.}, title = {Oral microalgae-based biosystem to enhance irreversible electroporation immunotherapy in hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Bimodal in situ analyzer for circular RNA in extracellular vesicles combined with machine learning for accurate gastric cancer detection. ADVS, 12(15), 2409202. (www)

  @article{ , abstract = {Circular RNAs in extracellular vesicles (EV-circRNAs) are gaining recognition as potential biomarkers for the diagnosis of gastric cancer (GC). Most current research is focused on identifying new biomarkers and their functional significance in disease regulation. However, the practical application of EV-circRNAs in the early diagnosis of GC is yet to be thoroughly explored due to the low accuracy of EV-circRNAs analysis. In this study, a hybridization chain reaction system based on rectangular DNA framework guidance and constructing a bimodal EV-circRNA in situ analyzer (BEISA) is developed. The analyzer can provide dual signal outputs in the fluorescence and electrochemical modes, enabling a self-correcting detection mechanism that significantly improves the accuracy of the assay. It has a broad detection range and an extremely low limit of detection. In a clinical cohort study, the BEISA used four circRNAs as biomarkers, combining them with machine learning for multiparametric analysis, which effectively differentiated between healthy donors and patients with early-stage GC. It is believed that the BEISA, in conjunction with machine learning technology, provides an efficient, sensitive, and reliable tool for EV-circRNA analysis, aiding in the early diagnosis of GC.}, archive = {J_ADVS}, author = {Yuhang Guo and Shihua Luo and Sinian Liu and Chao Yang and Weifeng Lv and Yuxin Liang and Tingting Ji and Wenbin Li and Chunchen Liu and Xin Li and Lei Zheng and Ye Zhang}, doi = {10.1002/advs.202409202}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2409202}, shortjournal = {Adv. Sci.}, title = {Bimodal in situ analyzer for circular RNA in extracellular vesicles combined with machine learning for accurate gastric cancer detection}, volume = {12}, year = {2025}, }
• (2025). Geniposidic acid targeting FXR “S332 and h447” mediated conformational change to upregulate CYPs and miR-19a-3p to ameliorate drug-induced liver injury. ADVS, 12(15), 2409107. (www)

  @article{ , abstract = {Drug-induced liver injury (DILI), caused by chemical drugs and traditional Chinese medicine, often leads to severe outcomes like liver failure due to a lack of early detection markers. Farnesoid X receptor (FXR), a key regulator of bile acid (BA) and cholesterol metabolism, is a potential therapeutic target. This study investigates the pathogenesis, markers, and treatment strategies for DILI, focusing on the hepatoprotective effects of geniposidic acid (GPA) from Gardenia jasminoides J. Ellis . Using cellular and animal models of acute and chronic DILI induced by acetaminophen and triptolide, we explored GPA's mechanisms in BA and cholesterol metabolism. Lipidomic and BA analyses revealed that GPA alleviates DILI by enhancing bile acid synthesis and transport via FXR activation. Experiments using AAV-shFXR, Fxr − / − mice and molecular assays demonstrated that GPA targets Ser332 and His447 on FXR ligand-binding domain, promoting FXR nuclear translocation and initiating cytochrome P450 proteins (CYPs) transcriptional activation for BA metabolism. Additionally, miRNA sequencing and RNA-pulldown assays showed that GPA-activated FXR upregulates miR-19a-3p, binding to LXR 3'UTR to inhibit cholesterol production. These findings reveal the GPA-FXR “structure-target” relationship, highlighting a dual mechanism in which GPA promotes CYPs-mediated bile acid metabolism and miR-19a-3p-mediated cholesterol synthesis inhibition, providing a basis for FXR-targeted DILI therapies.}, archive = {J_ADVS}, author = {Minqi Fan and Yuanhang Xu and Bingxin Wu and Jiachan Long and Caihong Liu and Zuhui Liang and Rong Zhang and Zhongqiu Liu and Caiyan Wang}, doi = {10.1002/advs.202409107}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2409107}, shortjournal = {Adv. Sci.}, title = {Geniposidic acid targeting FXR “S332 and h447” mediated conformational change to upregulate CYPs and miR-19a-3p to ameliorate drug-induced liver injury}, volume = {12}, year = {2025}, }
• (2025). Nanoodor particles deliver drugs to central nervous system via olfactory pathway. ADVS, 12(15), 2408908. (www)

  @article{ , abstract = {Central nervous system (CNS) disorders confront significant challenges in drug delivery due to the blood–brain barrier (BBB). Inspired by the rapid and precise binding of odor molecules to olfactory receptors (ORs), this research uses thiolated HPMA to construct odor nanoparticles (nanoodors) capable of delivering drugs to the CNS via the olfacto–cerebral pathway to overcome the delivery obstruction. The nanoodor core is used to encapsulate agomelatine (AGO), a CNS-targeting antidepressant, and the encapsulation efficiency exceeded 80%. A series of thiol-presenting nanoscale structures with different surface densities of thiol groups are constructed, and the effectiveness positively correlated with the density of thiol groups on their surface. Notably, the nanoodors enable precise brain-targeted delivery, outperforming commercially available oral formulations in terms of drug accumulation in the brain and antidepressant effects. The study of the nanoodor transport and action mechanisms revealed that after binding to ORs, the nanoodors are rapidly delivered to the brain via the olfactory pathway. Nanoodors, the first design to deliver CNS drugs via the olfactory pathway by mimicking natural smells for the treatment of CNS disorders, are expected to achieve clinical transformation, benefiting human health.}, archive = {J_ADVS}, author = {Wei Zhang and Xingwang Ji and Qianyanqiu Zhao and Jinyao Qi and Wen Guo and Gaoshuo Zhang and Yujing Guan and Shenglong Li and Yuling Mao}, doi = {10.1002/advs.202408908}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2408908}, shortjournal = {Adv. Sci.}, title = {Nanoodor particles deliver drugs to central nervous system via olfactory pathway}, volume = {12}, year = {2025}, }
• (2025). Fc proteoforms of ACPA IgG discriminate autoimmune responses in plasma and synovial fluid of rheumatoid arthritis patients and associate with disease activity. ADVS, 12(15), 2408769. (www)

  @article{ , abstract = {Autoantibodies and their post-translational modifications (PTMs) are insightful markers of autoimmune diseases providing diagnostic and prognostic clues, thereby informing clinical decisions. However, current autoantibody analyses focus mostly on IgG1 glycosylation representing only a subpopulation of the actual IgG proteome. Here, by taking rheumatoid arthritis (RA) as prototypic autoimmune disease, we sought to circumvent these shortcomings and illuminate the importance of (auto)antibody proteoforms employing a novel comprehensive mass spectrometry (MS)-based analytical workflow. Profiling of anti-citrullinated protein antibodies (ACPA) IgG and total IgG in paired samples of plasma and synovial fluid revealed a clear distinction of autoantibodies from total IgG and between biofluids. This discrimination relied on comprehensive subclass-specific PTM profiles including previously neglected features such as IgG3 C H 3 domain glycosylation, allotype ratios, and non-glycosylated IgG. Intriguingly, specific proteoforms were found to correlate with markers of inflammation and disease accentuating the need of such approaches in clinical investigations and calling for further mechanistic studies to comprehend the role of autoantibody proteoforms in defining autoimmune responses.}, archive = {J_ADVS}, author = {Constantin Blöchl and Eva Maria Stork and Hans Ulrich Scherer and Rene E. M. Toes and Manfred Wuhrer and Elena Domínguez-Vega}, doi = {10.1002/advs.202408769}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2408769}, shortjournal = {Adv. Sci.}, title = {Fc proteoforms of ACPA IgG discriminate autoimmune responses in plasma and synovial fluid of rheumatoid arthritis patients and associate with disease activity}, volume = {12}, year = {2025}, }
• (2025). Chchd10: A novel metabolic sensor modulating adipose tissue homeostasis. ADVS, 12(15), 2408763. (www)

  @article{ , abstract = {Dysregulation of adipose tissue (AT) homeostasis in obesity contributes to metabolic stress and disorders. Here, we identified that Coiled-coil-helix-coiled-coil-helix domain containing 10 (Chchd10) is a novel regulator of AT remodeling upon excess energy intake. Chchd10 is significantly reduced in the white adipose tissue (WAT) of mice in response to high-fat diet (HFD) feeding. AT-Chchd10 deficiency accelerates adipogenesis predominantly in subcutaneous AT of mice to store excess energy in response to short-term HFD feeding while upregulates glutathione S-transferase A4 (GSTA4) to facilitate 4-HNE clearance mainly in visceral AT to prevent protein carbonylation-induced cell dysfunction after long-term HFD feeding. Hence, Chchd10 deficiency attenuates diet-induced obesity and related metabolic disorders in mice. Mechanistically, Chchd10 deficiency enhances adipogenesis and GSTA4 expression by activating TDP43/Raptor/p62/Keap1/NRF2 axis. Notably, the beneficial effect of Chchd10 deficiency is eliminated in hypertrophic adipocytes, where p62 is strikingly reduced. Collectively, Chchd10 is a metabolic sensor maintaining AT homeostasis, and the loss of p62 in adipose tissue under obese conditions impairs Chchd10-mediated AT remodeling.}, archive = {J_ADVS}, author = {Xiaoping Wu and Zixuan Zhang and Jingjing Li and Jiuyu Zong and Lufengzi Yuan and Lingling Shu and Lai Yee Cheong and Xiaowen Huang and Mengxue Jiang and Zhihui Ping and Aimin Xu and Ruby L.C. Hoo}, doi = {10.1002/advs.202408763}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2408763}, shortjournal = {Adv. Sci.}, title = {Chchd10: A novel metabolic sensor modulating adipose tissue homeostasis}, volume = {12}, year = {2025}, }
• (2025). Enhancing nonenzymatic glucose detection through cobalt-substituted hafnia. ADVS, 12(15), 2408687. (www)

  @article{ , abstract = {Engineered defect chemistry in ultrathin (≈5 nm) hafnia through substitutional cobalt (HCO) is investigated for selective glucose sensing. Thin films of HCO, grown using chemical solution deposition (CSD)—traditionally used to grow thick films—on silicon, show significant glucose sensing activity and undergo monoclinic to orthorhombic phase transformation. The presence of multivalent cobalt in hafnia, with oxygen vacancies in proximity, selectively oxidizes glucose with minimal interference from ascorbic acid, dopamine, and uric acid. Theoretical investigations reveal that these oxygen vacancies create a shallow donor level that significantly enhances electrocatalytic activity by promoting charge transfer to the conduction band. This results in considerable selectivity, repeatability, and reproducibility in sensing characteristics. These findings highlight the technological importance of using CSD for thin films, paving the way for ultrathin CSD-processed HCOs as potential candidates for selective glucose sensing applications.}, archive = {J_ADVS}, author = {Jeonghyeon Oh and Avis Sin Hui Wee and Eun-Byeol Park and Jaejin Hwang and Seon Je Kim and Hu Young Jeong and Myat Thet Khine and Pavan Pujar and Jaekwang Lee and Young-Min Kim and Sunkook Kim}, doi = {10.1002/advs.202408687}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2408687}, shortjournal = {Adv. Sci.}, title = {Enhancing nonenzymatic glucose detection through cobalt-substituted hafnia}, volume = {12}, year = {2025}, }
• (2025). Mucous permeable nanoparticle for inducing cuproptosis-like death in broad-spectrum bacteria for nebulized treatment of acute pneumonia. ADVS, 12(15), 2408580. (www)

  @article{ , abstract = {The emergence of antibiotic-resistant bacteria has exacerbated the challenge of treating infectious diseases. Quorum sensing (QS), a bacterial communication system regulating virulence and biofilm formation, presents a target for novel therapies. Cuproptosis death is a innovation mode of death, however, this effect may be partially inhibited by glutathione (GSH). Buthionine sulfoximine (BSO) is responsible for GSH biosynthesis and has been identified as a potential promoter of cuproptosis death. Here, Cu 2 O-BSO NPs with lung adhesion and mucus penetration ability are synthesized by incorporating BSO onto Cu 2 O, and modifying it with DOPA and PEG. Cu 2 O-BSO NPs demonstrated a broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, making it a viable treatment option for MRSA-induced acute pneumonia. Specifically, Cu 2 O-BSO NPs can synergistically enhance bacterial cuproptosis-like death, hinder the QS system, eradicate biofilms, reduce the virulence of strains, stimulate the chemotaxis and phagocytosis of macrophages, and ultimately improve in mice with severe pneumonia. This research demonstrated the potential of Cu 2 O-BSO NPs for a wide-ranging antibacterial alternative, providing promise for addressing microbial resistance and combatting biofilm formation. Additionally, it established a target and theoretical foundation for the clinical treatment of numerous challenging cases of acute drug-resistant bacteria.}, archive = {J_ADVS}, author = {Huiqun Hu and Shiyuan Hua and Feng Lu and Wenting Zhang and Zengwen Zhang and Jiarong Cui and Xiaoyue Lei and Jingyan Xia and Feng Xu and Min Zhou}, doi = {10.1002/advs.202408580}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2408580}, shortjournal = {Adv. Sci.}, title = {Mucous permeable nanoparticle for inducing cuproptosis-like death in broad-spectrum bacteria for nebulized treatment of acute pneumonia}, volume = {12}, year = {2025}, }
• (2025). Acoustic rayleigh wave turbulence in soft viscoelastic matter. ADVS, 12(15), 2407528. (www)

  @article{ , abstract = {Evidence of discrete acoustic Rayleigh wave turbulence (DARWT) is reported on the free surface of complex viscoelastic materials under monochromatic excitation. These surface elastic non-linear Rayleigh waves exhibit dispersionless dynamics governed by bulk shear rigidity at coexistence with dispersive capillary waves supported by surface tension. Using Laser Doppler Vibrometry (LDV), the discrete Kolmogorov–Zakharov (KZ) spectrum is measured, characterized by a power-law envelope in an inertial cascade of discrete harmonics. When shear rigidity dominates, KZ-spectrum characterized by an ω −5/2 acoustic fingerprint is observed as a conservative solid-like scaling, theoretically predicted from the exact three-wave dispersionless resonance. Conversely, when surface tension dominates over bulk stresses, dispersive CW behavior under the usual ω −17/6 liquid-like scaling is recovered. These findings support a unique theoretical framework for understanding conservative DARWT and advance the field of surface wave turbulence in viscoelastic media with markedly non-Newtonian rheology. Acoustic Rayleigh wave turbulence represents a conservative mechanism for dispersionless energy transport through weakly nonlinear wave interactions across scales, with relevance to various physics fields, from soft matter and biological systems up to geophysical flows.}, archive = {J_ADVS}, author = {Mikheil Kharbedia and Horacio López-Menéndez and Basilio Javier García and Manuel G. Velarde and Francisco Monroy}, doi = {10.1002/advs.202407528}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2407528}, shortjournal = {Adv. Sci.}, title = {Acoustic rayleigh wave turbulence in soft viscoelastic matter}, volume = {12}, year = {2025}, }
• (2025). GABP promotes mesangial cell proliferation and renal fibrosis through GLI1 in diabetic nephropathy. ADVS, 12(15), 2407462. (www)

  @article{ , abstract = {Abnormal proliferation of mesangial cells is a hallmark of diabetic nephropathy (DN). However, the cellular signaling mechanisms that regulate this proliferation remain poorly understood. In this study, it is demonstrated that GA-binding protein (GABP), a member of the ETS family of transcription factors composed of GABPα and GABPβ, plays a significant role in the development of renal fibrosis by modulating mesangial cell proliferation. Notably, the deficiency of GABP in mesangial cells inhibits hyperglycemia-induced proliferation and mitigates renal fibrosis in a murine model of type 2 diabetes mellitus (T2DM). RNA sequencing analysis identifies GLI Family Zinc Finger 1 (GLI1) as the principal downstream effector of GABP in diabetic mice, serving as a crucial regulator of the G1/S transition within the cell cycle. Subsequent investigations have demonstrated that GABP interacts with the GLI1 promoter, facilitating mesangial cell proliferation via GLI1-dependent pathways. This is evidenced by the fact that GLI1 knockdown abrogates the proliferation of mesangial cells with GABP overexpression. Consequently, GABP emerges as a pivotal regulator of renal fibrosis and represents a promising therapeutic target for the treatment of diabetic nephropathy.}, archive = {J_ADVS}, author = {Lei Du and Sijie Liu and Yinfei Lu and Dongxue Ren and Xiujuan Yu and Yue Hu and Tingting Yang and Qun Yang and Jingxian Ming and Jiawei Zhang and Xiaoxing Yin and Qian Lu}, doi = {10.1002/advs.202407462}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2407462}, shortjournal = {Adv. Sci.}, title = {GABP promotes mesangial cell proliferation and renal fibrosis through GLI1 in diabetic nephropathy}, volume = {12}, year = {2025}, }
• (2025). T-cell-dependent bispecific IgGs protect aged mice from lethal SARS-CoV-2 infection. ADVS, 12(15), 2406980. (www)

  @article{ , abstract = {T-cell ageing may be a key factor in the disproportionate severity of coronavirus disease 2019 (COVID-19) in older populations. For hospitalized COVID-19 patients, treatment involving the use of monoclonal antibodies with the ability to neutralize SARS-CoV-2 usually involves the administration of high doses but has not been very effective at preventing complications or fatality, highlighting the need for additional research into anti-SARS-CoV-2 therapies, particularly for older populations. In this study, it is discovered that older persons with a severe SARS-CoV-2 infection has weaker T-cell responses. Therefore the development and characterization of spike-targeting T-cell-dependent bispecific (TDB) full-length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID-19 is described. Using S-targeting TDBs, polyclonal T cells are guided to target and destroy S-expressing cells, preventing the cell-to-cell transmission of SARS-CoV-2 and thereby eliminating the need for SARS-CoV-2-specific immunity. Using animal models of COVID-19, it is shown that the selective activation of T cells improves the efficiency of treatment in preinfected mice by attenuating disease-induced weight loss and death. The significance of T-cell-based immunity during infection is highlighted by the findings. These results have implications for better clinical effectiveness of therapies for COVID-19 and the development of T-cell-dependent medicines for the elderly population.}, archive = {J_ADVS}, author = {Wenyan Fu and Wei Zhang and Zhongshuai You and Guangyao Li and Chuqi Wang and Changhai Lei and Jian Zhao and Jin Hou and Shi Hu}, doi = {10.1002/advs.202406980}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2406980}, shortjournal = {Adv. Sci.}, title = {T-cell-dependent bispecific IgGs protect aged mice from lethal SARS-CoV-2 infection}, volume = {12}, year = {2025}, }
• (2025). UFMylation of NLRP3 prevents its autophagic degradation and facilitates inflammasome activation. ADVS, 12(15), 2406786. (www)

  @article{ , abstract = {NLRP3 (NOD, LRR and pyrin domain-containing protein 3) inflammasome is important for host defense against infections and maintaining homeostasis. Aberrant activation of NLRP3 inflammasome is closely related to various inflammatory diseases. Post-translational modifications are critical for NLRP3 inflammasome regulation. However, the mechanism of NLRP3 inflammasome activation remains incompletely understood. Here, it is demonstrated that the Ufm1 E3 ligase Ufl1 mediated UFMylation is essential for NLRP3 inflammasome activation. Mechanistically, Ufl1 binds and UFMylates NLRP3 in the priming stage of NLRP3 activation, thereby sustaining the stability of NLRP3 by preventing NLRP3 K63-linked ubiquitination and the subsequent autophagic degradation. It is further demonstrated that myeloid cell-specific Ufl1 or Ufm1 deficiency in mice significantly alleviated inflammatory responses and tissue damage following lipopolysaccharide (LPS)-induced endotoxemia and alum-induced peritonitis. Thus, the findings offer new insights into potential therapeutic targets for NLRP3 inflammasome-related diseases by targeting the UFMylation system.}, archive = {J_ADVS}, author = {Jiongjie Jing and Fan Yang and Ke Wang and Mintian Cui and Ni Kong and Shixi Wang and Xiaoyue Qiao and Fanyu Kong and Dongyang Zhao and Jinlu Ji and Lunxian Tang and Jiaxin Gao and Yu-Sheng Cong and Deqiang Ding and Kun Chen}, doi = {10.1002/advs.202406786}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2406786}, shortjournal = {Adv. Sci.}, title = {UFMylation of NLRP3 prevents its autophagic degradation and facilitates inflammasome activation}, volume = {12}, year = {2025}, }
• (2025). Machine learning techniques for simulating human psychophysical testing of low-resolution phosphene face images in artificial vision. ADVS, 12(15), 2405789. (www)

  @article{ , abstract = {To evaluate the quality of artificial visual percepts generated by emerging methodologies, researchers often rely on labor-intensive and tedious human psychophysical experiments. These experiments necessitate repeated iterations upon any major/minor modifications in the hardware/software configurations. Here, the capacity of standard machine learning (ML) models is investigated to accurately replicate quaternary match-to-sample tasks using low-resolution facial images represented by arrays of phosphenes as input stimuli. Initially, the performance of the ML models trained to approximate innate human facial recognition abilities across a dataset comprising 3600 phosphene images of human faces is analyzed. Subsequently, due to the time constraints and the potential for subject fatigue, the psychophysical test is limited to presenting only 720 low-resolution phosphene images to 36 human subjects. Notably, the superior model adeptly mirrors the behavioral trend of human subjects, offering precise predictions for 8 out of 9 phosphene quality levels on the overlapping test queries. Subsequently, human recognition performances for untested phosphene images are predicted, streamlining the process and minimizing the need for additional psychophysical tests. The findings underscore the transformative potential of ML in reshaping the research paradigm of visual prosthetics, facilitating the expedited advancement of prostheses.}, archive = {J_ADVS}, author = {Na Min An and Hyeonhee Roh and Sein Kim and Jae Hun Kim and Maesoon Im}, doi = {10.1002/advs.202405789}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2405789}, shortjournal = {Adv. Sci.}, title = {Machine learning techniques for simulating human psychophysical testing of low-resolution phosphene face images in artificial vision}, volume = {12}, year = {2025}, }
• (2025). The antiviral efficacy and safety of azvudine in hospitalized SARS-CoV-2 infected patients with liver diseases based on a multicenter, retrospective cohort study. ADVS, 12(15), 2405679. (www)

  @article{ , abstract = {Despite azvudine being prioritized for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, its effectiveness and safety remain inadequately substantiated in hospitalized SARS-CoV-2 infected patients with liver diseases. A retrospective nine-center cohort study along with an independent validation cohort is conducted to examine the efficacy of azvudine (Clinical Trial Registration Number: NCT06349655). The primary outcome is all-cause mortality and the secondary outcome is composite disease progression. Efficacy is assessed via Kaplan–Meier analysis and Cox regression, with subgroup and sensitivity analyses for further validation. Among 32 864 hospitalized SARS-CoV-2 infected patients, 1022 eligible azvudine recipients, and 1022 controls are included through propensity score match. Kaplan–Meier analysis reveals that azvudine treatment is associated with a lower risk of all-cause mortality and composite disease progression (both p <0.0001). Cox regression analysis suggests azvudine recipients could have a 39% lower risk of all-cause mortality than controls (95% confidence interval [CI]: 0.468–0.795, p <0.001), but with no notable significance in composite disease progression (hazard ratio: 0.85, 95% CI: 0.686-1.061, p = 0.154). Subgroup analysis suggests that azvudine has a greater benefit for both all-cause mortality and composite disease progression in patients with kidney diseases or without autoimmune diseases. Three sensitivity analyses and validation cohorts confirm the robustness of the findings. Safety analysis observes few adverse events in azvudine recipients. Within 15 days after azvudine administration, no significant difference in liver function indexes and kidney function indexes is observed between the two groups except for a few time points. These findings demonstrate that azvudine shows potential clinical efficacy in improving all-cause mortality in hospitalized SARS-CoV-2 infected patients with liver diseases, with acceptable adverse effects.}, archive = {J_ADVS}, author = {Junyi Sun and Mengzhao Yang and Guanyue Su and Ling Wang and Xiaobo Hu and Yongjian Zhou and Guangying Cui and Guowu Qian and Yiqiang Yuan and Xinjun Hu and Silin Li and Hong Luo and Shixi Zhang and Guangming Li and Donghua Zhang and Guotao Li and Ming Cheng and Zujiang Yu and Zhigang Ren}, doi = {10.1002/advs.202405679}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2405679}, shortjournal = {Adv. Sci.}, title = {The antiviral efficacy and safety of azvudine in hospitalized SARS-CoV-2 infected patients with liver diseases based on a multicenter, retrospective cohort study}, volume = {12}, year = {2025}, }
• (2025). 3D-AJP: Fabrication of advanced microarchitected multimaterial ceramic structures via binder-free and auxiliary-free aerosol jet 3D nanoprinting. ADVS, 12(15), 2405334. (www)

  @article{ , abstract = {Manufacturing of ceramics is challenging due to their low toughness and high hardness. Additive Manufacturing (AM) has been explored to create complex ceramic structures, but current techniques face a tradeoff between precisely controlled feature sizes and high shrinkage at the microscales. Here, we introduce 3D-AJP, a novel freeform ceramic fabrication method that enables highly complex microscale 3D ceramic architectures—such as micropillars, spirals, and lattices—with minimal shrinkage and no auxiliary support. Using a near-binder-free nanoparticle ink in an Aerosol Jet (AJ) 3D printer, our approach precisely controls feature sizes down to 20 µm with aspect ratios up to 30:1. The resulting structures exhibit exceptionally low linear shrinkage of 2-6% upon sintering, spanning five orders of magnitude in length scale. Bi-material 3D architectures (zinc oxide/zirconia, zinc oxide/titania, titania/zirconia) and hybrid ceramics further demonstrate the technique’s versatility. We showcase two key applications. First, 3D ceramic photocatalysts improve water purification performance, achieving a 400% increase in photocatalytic efficiency compared to bulk ceramics. Second, we develop a highly sensitive Her2 biomarker sensor for breast cancer detection, achieving a 22-second response time and a record-low detection limit of 0.0193 f m . Our technique will lead to high-performance sensing, filtration, microelectronics packaging, catalysis, and tissue regeneration technologies.}, archive = {J_ADVS}, author = {Chunshan Hu and Sanjida Jahan and Bin Yuan and Rahul Panat}, doi = {10.1002/advs.202405334}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2405334}, shortjournal = {Adv. Sci.}, title = {3D-AJP: Fabrication of advanced microarchitected multimaterial ceramic structures via binder-free and auxiliary-free aerosol jet 3D nanoprinting}, volume = {12}, year = {2025}, }
• (2025). Curcumin modulates PTPRZ1 activity and RNA m6A modifications in neuroinflammation-associated microglial response. ADVS, 12(15), 2405263. (www)

  @article{ , abstract = {Neuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti-inflammatory and antioxidant properties, can mitigate microglial hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's modulation of RNA post-transcriptional N (6)-methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1-type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A-reader YTH domain-containing family protein 2 (YTHDF2). This modulation affects the expression of critical genes, resulting in reduced inflammatory responses. These findings highlight the importance of post-transcriptional modifications of RNA in the neuroprotective and anti-inflammatory effects of curcumin, offering new insights for the treatment of related diseases.}, archive = {J_ADVS}, author = {Ninan Zhang and Ruifan Lin and Wenya Gao and Honglin Xu and Yuejia Li and Xiahe Huang and Yingchun Wang and Xianghong Jing and Wenxiang Meng and Qi Xie}, doi = {10.1002/advs.202405263}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2405263}, shortjournal = {Adv. Sci.}, title = {Curcumin modulates PTPRZ1 activity and RNA m6A modifications in neuroinflammation-associated microglial response}, volume = {12}, year = {2025}, }
• (2025). The placenta regulates intrauterine fetal growth via exosomal PPARγ. ADVS, 12(15), 2404983. (www)

  @article{ , abstract = {Abnormal adipogenesis is a major contributor to fetal growth restriction (FGR) and its associated complications. However, the underlying etiology remains unclear. Here, it is reported that the placentas of women with pregnancies complicated with FGR exhibit peroxisome proliferator-activated receptor γ (PPARγ) inactivation. In mice, trophoblast-specific ablation of murine PPARγ reproduces the phenotype of human fetuses with FGR and defective adipogenesis. Coculture of trophoblasts with preadipocytes significantly improves preadipocyte commitment and differentiation and increases the transcription of a series of adipogenic genes via intercellular transfer of exosomal PPARγ proteins. Moreover, nanoparticle-mediated placenta-specific delivery of rosiglitazone (RGZ) significantly rescues adipogenesis defects in an FGR-induced mouse model. In summary, the placenta is a major reservoir of PPARγ. An insufficient supply of placental PPARγ to fetal preadipocytes via exosomes during late gestation is a major mechanism underlying FGR. Preclinically, placenta-targeted RGZ administration can be a promising interventional therapy for FGR and/or defective intrauterine fat development.}, archive = {J_ADVS}, author = {Xiaofang Luo and Biao Huang and Ping Xu and Hao Wang and Baozhen Zhang and Li Lin and Jiujiang Liao and Mingyu Hu and Xiyao Liu and Jiayu Huang and Yong Fu and Mark D. Kilby and Rodney E. Kellems and Xiujun Fan and Yang Xia and Philip N. Baker and Hongbo Qi and Chao Tong}, doi = {10.1002/advs.202404983}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2404983}, shortjournal = {Adv. Sci.}, title = {The placenta regulates intrauterine fetal growth via exosomal PPARγ}, volume = {12}, year = {2025}, }
• (2025). A silk fibroin nanoparticle hydrogel loaded with NK1R antagonist has synergistic anti-inflammatory and reparative effects on dry eye disease. ADVS, 12(15), 2404835. (www)

  @article{ , abstract = {Dry eye disease (DED) is a multifactorial illness affecting tears and the ocular surface. The neurokinin 1 receptor (NK1R) is a target for controlling T helper 17 (Th17) and regulatory T cell (Treg) imbalances. This work creates a silk fibroin (SF) nanoparticle hydrogel that targets NK1R with CP-99,994 (CP). Combining CP and SF to generate stable nanoparticles while integrating a flexible hydrogel material results in a sustained-release ophthalmic drop formulation (SF@CP@Gel), which provides a long-lasting ocular formulation with anti-inflammatory and reparative properties. SF@CP@Gel could maintain a stable CP concentration for 25 h with detectable biological activity. The cell counting kit-8 and 2,7-DHL-DA results reveal that SF@CP@Gel has no cytotoxic effect on human corneal epithelial cells (HCECs) and decreases the reactive oxygen species level in oxidatively damaged HCECs. Cell scratch assays demonstrate that SF@CP@Gel can greatly increase HCEC migration and proliferation within 24 h. Furthermore, in vivo therapy with topical SF@CP@Gel twice daily markedly reduce clinical symptoms by reducing the amount of pathogenic Th17 cells while efficiently restoring Treg activity. In summary, this work reveals that SF@CP@Gel might attenuate DED by inhibiting NK1R-mediated SP signaling and thereby modulating the Th17/Treg ratio, a potential anti-inflammatory and repair treatment method for DED.}, archive = {J_ADVS}, author = {Bo Gong and Yi Liu and Huan Li and Xueming Ju and Dongfeng Li and Yuhao Zou and Xiaoxin Guo and Kai Dong and Jialing Xiao and Weijia Wu and Renjie Chai and Ruifan Zhang and Man Yu}, doi = {10.1002/advs.202404835}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2404835}, shortjournal = {Adv. Sci.}, title = {A silk fibroin nanoparticle hydrogel loaded with NK1R antagonist has synergistic anti-inflammatory and reparative effects on dry eye disease}, volume = {12}, year = {2025}, }
• (2025). A conformationally driven mechanism in n-type doping of naphthalene diimide-bithiophene copolymer by 1H-benzimidazoles. ADVS, 12(15), 2402482. (www)

  @article{ , abstract = {N-doped polymer semiconductors are of great interest in the field of organic thermoelectrics, as high-conductive materials are still highly desired. In this framework, this paper aims to clarify whether the n-doping of naphthalene diimide-bithiophene copolymer, P(NDI2OD-T2), by 1H-benzimidazoles is a thermally activated process. The study interestingly demonstrates that a relevant change in conductivity, with an increase of more than three orders of magnitude with respect to pristine P(NDI2OD-T2), occurs before the annealing process takes place, thus revealing that benzimidazole-derived dopants are already active at room temperature. Moreover, despite the annealing time and temperature affecting the electrical conductivity of the system, their contribution is less relevant, with the increase of electrical conductivity limited to up to three times. The results from the electrical characterization of the samples are supported by infrared spectroscopy investigation and X-ray analysis, revealing the marker bands of polaron and a manifest structural change between the undoped and the just-doped P(NDI2OD-T2) films, accompanied by only minor modifications during the annealing process. Finally, based on the results of density functional theory simulations, the conformational modifications of the 1H-benzimidazole dopant molecules, induced by the interaction with the P(NDI2OD-T2), are proposed as a possible mechanism explaining the effective doping at room temperature.}, archive = {J_ADVS}, author = {Simone Cimò and Ilaria Denti and Lorenzo Rossi and Marco Cassinelli and Martina Rossi and Rossella Castagna and Garrett LeCroy and Alberto Salleo and Mario Caironi and Antonino Famulari and Chiara Castiglioni and Chiara Bertarelli}, doi = {10.1002/advs.202402482}, journal = {Advanced Science}, month = {4}, number = {15}, pages = {2402482}, shortjournal = {Adv. Sci.}, title = {A conformationally driven mechanism in n-type doping of naphthalene diimide-bithiophene copolymer by 1H-benzimidazoles}, volume = {12}, year = {2025}, }
• (2025). Therapeutic black phosphorus nanosheets elicit neutrophil response for enhanced tumor suppression (Adv. sci. 14/2025). ADVS, 12(14), 2570100. (www)

  @article{ , archive = {J_ADVS}, author = {Jing Wang and Weiqiang Yu and Hui Shen and Yanxiang Sang and Hongjie Zhang and Benyan Zheng and Xue Peng and Yuan Hu and Xiaopeng Ma and Zhenye Yang and Fazhi Yu}, doi = {10.1002/advs.202570100}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2570100}, shortjournal = {Adv. Sci.}, title = {Therapeutic black phosphorus nanosheets elicit neutrophil response for enhanced tumor suppression (Adv. sci. 14/2025)}, volume = {12}, year = {2025}, }
• (2025). Rational design of natural xanthones against gram-negative bacteria (Adv. sci. 14/2025). ADVS, 12(14), 2570099. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaojia Liu and Meirong Song and Ying Liu and Shuyu Yang and Shang Chen and Jijun Kang and Jianzhong Shen and Kui Zhu}, doi = {10.1002/advs.202570099}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2570099}, shortjournal = {Adv. Sci.}, title = {Rational design of natural xanthones against gram-negative bacteria (Adv. sci. 14/2025)}, volume = {12}, year = {2025}, }
• (2025). Disturbing Cholesterol/Sphingolipid metabolism by squalene epoxidase arises crizotinib hepatotoxicity (Adv. sci. 14/2025). ADVS, 12(14), 2570098. (www)

  @article{ , archive = {J_ADVS}, author = {Hao Yan and Xiangliang Huang and Yourong Zhou and Yuan Mu and Shaoyin Zhang and Yashi Cao and Wentong Wu and Zhifei Xu and Xueqin Chen and Xiaochen Zhang and Xiaohong Wang and Xiaochun Yang and Bo Yang and Qiaojun He and Peihua Luo}, doi = {10.1002/advs.202570098}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2570098}, shortjournal = {Adv. Sci.}, title = {Disturbing Cholesterol/Sphingolipid metabolism by squalene epoxidase arises crizotinib hepatotoxicity (Adv. sci. 14/2025)}, volume = {12}, year = {2025}, }
• (2025). Nuclear to cytoplasmic transport is a druggable dependency in HDAC7-driven small cell lung cancer (Adv. sci. 14/2025). ADVS, 12(14), 2570096. (www)

  @article{ , archive = {J_ADVS}, author = {Tingting Qin and Jingya Wang and Jian Wang and Qingwu Du and Liuchun Wang and Hailin Liu and Wenting Liu and Xueyang Li and Yantao Jiang and Qi Xu and Junjie Yu and Huiyan Liu and Ting Wang and Mengjie Li and Dingzhi Huang}, doi = {10.1002/advs.202570096}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2570096}, shortjournal = {Adv. Sci.}, title = {Nuclear to cytoplasmic transport is a druggable dependency in HDAC7-driven small cell lung cancer (Adv. sci. 14/2025)}, volume = {12}, year = {2025}, }
• (2025). Electrically-shielded coil-enabled battery-free wireless sensing for underwater environmental monitoring (Adv. sci. 14/2025). ADVS, 12(14), 2570095. (www)

  @article{ , archive = {J_ADVS}, author = {Ke Wu and Xia Zhu and Stephan W. Anderson and Xin Zhang}, doi = {10.1002/advs.202570095}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2570095}, shortjournal = {Adv. Sci.}, title = {Electrically-shielded coil-enabled battery-free wireless sensing for underwater environmental monitoring (Adv. sci. 14/2025)}, volume = {12}, year = {2025}, }
• (2025). Improved efficacy of triple-negative breast cancer immunotherapy via hydrogel-based co-delivery of CAR-T cells and mitophagy agonist (Adv. sci. 14/2025). ADVS, 12(14), 2570094. (www)

  @article{ , archive = {J_ADVS}, author = {Guodong Li and Ruoxin Du and Donghui Wang and Xiangmei Zhang and Lizhuo Wang and Shuangpeng Pu and Xiaoju Li and Shuning Wang and Juliang Zhang and Beichen Liu and Yuan Gao and Huadong Zhao}, doi = {10.1002/advs.202570094}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2570094}, shortjournal = {Adv. Sci.}, title = {Improved efficacy of triple-negative breast cancer immunotherapy via hydrogel-based co-delivery of CAR-T cells and mitophagy agonist (Adv. sci. 14/2025)}, volume = {12}, year = {2025}, }
• (2025). Pericytes promote more vascularization than stromal cells via an interleukin-6-dependent mechanism in microfluidic chips (Adv. sci. 14/2025). ADVS, 12(14), 2570093. (www)

  @article{ , archive = {J_ADVS}, author = {Julian Gonzalez-Rubio and Hannah Kubiza and Yong Xu and Hiltrud Koenigs-Werner and Mona Sophie Schmitz and Michaela Schedel and Christian Apel and Stefan Jockenhoevel and Christian G. Cornelissen and Anja Lena Thiebes}, doi = {10.1002/advs.202570093}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2570093}, shortjournal = {Adv. Sci.}, title = {Pericytes promote more vascularization than stromal cells via an interleukin-6-dependent mechanism in microfluidic chips (Adv. sci. 14/2025)}, volume = {12}, year = {2025}, }
• (2025). Mitoxantrone-encapsulated ZIF-8 enhances chemo-immunotherapy via amplified immunogenic cell death. ADVS, 12(14), 2501542. (www)

  @article{ , abstract = {Chemo-immunotherapy, combining systemic chemotherapeutic drugs and immune checkpoint blockers, is a promising paradigm in cancer treatment. However, challenges such as limited induction of immune responses and systemic immune toxicity have hindered its clinical applications. Here, a zeolite imidazolate framework-8 (ZIF-8) that encapsulates mitoxantrone (MIT), an immune cell death (ICD)-inducing chemotherapeutic agent (MIT@ZIF-8), is synthesized using a one-pot aqueous-phase process. ZIF-8 serves as a dual-functional nanomaterial for chemo-immunotherapy: a carrier to enhance tumor uptake of MIT for improved chemotherapy efficacy, and a pyroptosis inducer to amplify MIT-induced ICD for augmented anti-tumor immune responses. As a result, in vivo administration of MIT@ZIF-8 markedly inhibits tumor growth in both immunologically “hot” colon cancer and immunologically “cold” prostate cancer. Moreover, MIT@ZIF-8 treatment increases the abundance of cytotoxic CD8 + T cells and reduces the amount of immunosuppressive regulatory T cells in tumors, thereby enhancing anti-tumor immunity and sensitizing prostate cancer to anti-CTLA-4 immunotherapy. In summary, MIT@ZIF-8 offers a highly translational approach for chemo-immunotherapy.}, archive = {J_ADVS}, author = {Junhong Li and Wenxing Lv and Ziwei Han and Yike Li and Jinqi Deng and Yanjuan Huang and Shuo Wan and Jiashu Sun and Bo Dai}, doi = {10.1002/advs.202501542}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2501542}, shortjournal = {Adv. Sci.}, title = {Mitoxantrone-encapsulated ZIF-8 enhances chemo-immunotherapy via amplified immunogenic cell death}, volume = {12}, year = {2025}, }
• (2025). Engineered nanocatalyst-enabled cheolesterol depletion for enhanced tumor piezocatalytic therapy. ADVS, 12(14), 2500967. (www)

  @article{ , abstract = {The inadequate generation of reactive oxygen species (ROS) and metastasis of malignant tumors are critical factors that limit the efficacy of conventional sonodynamic therapy in cancer treatment. Herein, an engineered piezocatalyst: cholesterol oxidase (CHO)-loaded Pt-ZnO nanoparticles (Pt-ZnO/CHO) that can explosively generate large amounts of ROS and block the metastasis of tumor, is developed for improving piezocatalytic tumor therapy. In this process, Pt-ZnO can substantially generate ROS via initiating ultrasound (US)-triggered piezocatalytic reactions. In situ-grown Pt nanoparticles not only optimize piezocatalytic activities but also facilitate oxygen (O 2 ) production, thereby synergistically boosting ROS generation. Moreover, O 2 produced by Pt-ZnO can accelerate the depletion of excess cholesterol in tumor cells under CHO catalysis to disrupt the integrity of lipid rafts and inhibit the formation of lamellipodia, significantly suppressing the proliferation and metastasis of tumor cells. This strategy by promoting ROS generation and blocking the metastatic pathway of cancer cells offers a new idea for enhanced efficacy-oriented cancer therapeutic strategies.}, archive = {J_ADVS}, author = {Mengdan Li and Yajun Zhou and Xiaoyang Chen and Weiwei Chen and Yifei Yang and Cheng Qian and Lei Yang and Yaohan Zhang and Zheng Zhang and Wencheng Wu and Yifei Yin}, doi = {10.1002/advs.202500967}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2500967}, shortjournal = {Adv. Sci.}, title = {Engineered nanocatalyst-enabled cheolesterol depletion for enhanced tumor piezocatalytic therapy}, volume = {12}, year = {2025}, }
• (2025). Restoring tumor cell immunogenicity through ion-assisted p53 mRNA domestication for enhanced in situ cancer vaccination effect. ADVS, 12(14), 2500825. (www)

  @article{ , abstract = {The efficacy of in situ cancer vaccines (ISCVs) is hindered by the poor immunogenicity of tumor cells. Here, PRIZE, a P53-repair nanosystem based on a virus-mimicking nanostructure to deliver p53 mRNA and Zn (II) into tumor cells, domesticating tumor cells by restoring intracellular P53 levels to bolster their immunogenicity, is designed. PRIZE ensures precise delivery to tumor sites, stabilizes p53 mRNA with its biomineralized structure, and extends the half-life of P53. This research highlights that PRIZE can efficiently repair P53 abnormalities in 4T1 (P53-deficient) and MC38 (P53-mutant) cells, subsequently upregulating the expression of major histocompatibility complex (MHC) class I molecules and the surface co-stimulatory molecule CD80 on tumor cells, enhancing antigen presentation and transforming tumor cells into in situ antigen reservoirs. The co-delivered photothermal agent (ICG) can trigger immunogenic cell death under laser irradiation, effectively releasing tumor-associated antigens, and inducing the formation of ISCVs. Importantly, in P53 abnormal tumor mouse models, the induced ISCVs initiate the cancer immune cycle (CIC), demonstrating outstanding tumoricidal immunity and effectively thwarting tumor metastasis and postoperative recurrence, which provides valuable insights for advancing personalized cancer immunotherapy.}, archive = {J_ADVS}, author = {Yan Liang and Jingge Zhang and Jinjin Wang and Yuhe Yang and Xinyu Tan and Shuguang Li and Zhenzhen Guo and Zhenzhong Zhang and Junjie Liu and Jinjin Shi and Kaixiang Zhang}, doi = {10.1002/advs.202500825}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2500825}, shortjournal = {Adv. Sci.}, title = {Restoring tumor cell immunogenicity through ion-assisted p53 mRNA domestication for enhanced in situ cancer vaccination effect}, volume = {12}, year = {2025}, }
• (2025). High output voltage aqueous supercapacitors by water deactivated electrolyte over wide temperature range. ADVS, 12(14), 2500385. (www)

  @article{ , abstract = {Confined by factors such as low operating voltage, poor temperature resistance, and instability at high voltage, the energy density of conventional symmetric aqueous supercapacitors is undesirable over a wide temperature range. It is still challenging to develop aqueous flexible supercapacitors (AFSCs) that can provide stable and high voltage output (>2.0 V) at extreme ambient temperatures. Here, a strategy for constructing AFSC with ultrahigh output voltages over a wide temperature range is proposed through the development of organohydrogel electrolytes (OHEs) with excellent water deactivation, which achieve a notable output voltage of 3.0 V, and unprecedented energy densities of 23.16 µWh cm −2 at −40 °C (beyond 25 °C), surpassing the performance of all previously reported symmetric supercapacitors with aqueous electrolytes. Theoretical calculations and experimental analyses show that OHEs can deactivate water to increase the output voltage limit of AFSCs by enhancing intermolecular interactions and regulating inter Helmholtz plane. Meanwhile, it also shows excellent flexibility and cycling stability (80.5% after 20 000 cycles at 25 °C and 97.0% after 50 000 cycles at −40 °C). More importantly, OHEs enable AFSCs switchable output voltages (from 2.5 to 3.0 V), making it possible to operate supercapacitors with high energy density and stability at low temperatures.}, archive = {J_ADVS}, author = {Hongji Wang and Wenpeng Liu and Jin Huang and Tianliang Xiao and Wenwei Lei and Faming Gao and Mingjie Liu}, doi = {10.1002/advs.202500385}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2500385}, shortjournal = {Adv. Sci.}, title = {High output voltage aqueous supercapacitors by water deactivated electrolyte over wide temperature range}, volume = {12}, year = {2025}, }
• (2025). The crosstalk with CXCL10-rich tumor-associated mast cells fuels pancreatic cancer progression and immune escape. ADVS, 12(14), 2417724. (www)

  @article{ , abstract = {Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, necessitating approaches to improve prognosis. As the mediator of allergic process, mast cells have been found in various cancers and are associated with survival. However, the biological behaviors of tumor-associated mast cells (TAMCs) remain unclear. Herein, an excessive infiltration of TAMCs in PDAC is demonstrated, which apparently associated with poor survival in PDAC patients. PDAC cells are found to recruit CXCR2 + MCs into TME, and then inhibited MCs ferroptosis, and maintained their proliferation. Concomitantly, the tumor-derived exosome miR-188-5p activated the PTEN/AKT/GSK3β signaling, further stabilized transcriptional factor ERG by inhibiting its ubiquitin degradation, and finally enhanced the transcription of cxcl10 within TAMCs. In reverse, TAMCs-derived CXCL10 reversely promoted tumor epithelial-mesenchymal transition and induced immunosuppressive tumor microenvironment by recruiting CXCR3 + Tregs. Sodium cromoglycate (SCG) is a membrane stabilizer for MCs and confirmed as an effective and widely used agent to block TAMCs-derived CXCL10 and further sensitize the therapeutic efficacy of anti-PD-1 antibody plus gemcitabine for PDAC. These findings illuminate a critical and innovative crosstalk between TAMCs and PDAC cells that promote PDAC progression, and SCG sensitizes PDAC to the current immuno-chemotherapy, which reveals its potential to be a valuable adjuvant for PDAC patients.}, archive = {J_ADVS}, author = {Hanlin Yin and Qiangda Chen and Shanshan Gao and Sami Shoucair and Yuqi Xie and Joseph R. Habib and Taochen He and Wei Gan and Juan Wang and Lei Zhang and Huaxiang Xu and Chenye Shi and Junyi He and Wenquan Wang and Yun Jin and Michael G Goggins and Liang Liu and Wenhui Lou and Wenchuan Wu and Jun Yu and Ning Pu}, doi = {10.1002/advs.202417724}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2417724}, shortjournal = {Adv. Sci.}, title = {The crosstalk with CXCL10-rich tumor-associated mast cells fuels pancreatic cancer progression and immune escape}, volume = {12}, year = {2025}, }
• (2025). Carnosic acid directly targets STING C-terminal tail to improve STING-mediated inflammatory diseases. ADVS, 12(14), 2417686. (www)

  @article{ , abstract = {cGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes) signaling plays a vital role in innate immunity, while its deregulation may lead to a wide variety of autoinflammatory and autoimmune diseases. It is essential to identify specifically effective lead compounds to inhibit the signaling. Herein, it is shown that carnosic acid (CA), an active ingredient of medicinal plant Rosmarinus officinalis L ., specifically suppressed cGAS-STING pathway activation and the subsequent inflammatory responses. Mechanistically, CA directly bound to STING C-terminal tail (CTT), impeded the recruitment of TANK-binding kinase 1 (TBK1) onto STING signalosome, thereby blocking the phosphorylation of STING and interferon regulatory factor 3 (IRF3) nuclear translocation. Importantly, CA dramatically attenuated STING-mediated inflammatory responses in vivo. Consistently, CA has a salient ameliorative effect on autoinflammatory disease model mediated by Trex1 deficiency, via inhibition of the cGAS-STING signaling. Notably, the study further indicates that phenolic hydroxyl groups are essential for CA-mediated STING inhibitory activity. Collectively, the results thus identify STING as one of the crucial targets of CA for mediating CA's anti-inflammatory activity, and further reveal that STING CTT may be a novel promising target for drug development.}, archive = {J_ADVS}, author = {Wenqing Mu and Guang Xu and Ling Li and Jincai Wen and Ye Xiu and Jia Zhao and Tingting Liu and Ziying Wei and Wei Luo and Huijie Yang and Zhixin Wu and Xiaoyan Zhan and Xiaohe Xiao and Zhaofang Bai}, doi = {10.1002/advs.202417686}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2417686}, shortjournal = {Adv. Sci.}, title = {Carnosic acid directly targets STING C-terminal tail to improve STING-mediated inflammatory diseases}, volume = {12}, year = {2025}, }
• (2025). GPR37 activation alleviates bone cancer pain via the inhibition of osteoclastogenesis and neuronal hyperexcitability. ADVS, 12(14), 2417367. (www)

  @article{ , abstract = {Osteolytic bone cancer pain is a primary concern for cancer patients with bone metastasis, and current therapies offer inadequate pain relief. The present study demonstrates that activation of the G protein-coupled receptor 37 (GPR37) by neuroprotectin D1 (NPD1) or artesunate (ARU) alleviates both acute and persistent pain in multiple mouse models of bone cancer. GPR37 agonists also protect against cancer-induced bone destruction. Mechanistically, NPD1 or ARU binding to GPR37 in macrophages promotes the release of IL-10, which further inhibits cancer-induced osteoclastogenesis. Moreover, direct activation of GPR37 in dorsal root ganglion (DRG) neurons and the spinal dorsal horn reduces action potential firing and the frequency of spontaneous excitatory postsynaptic currents (sEPSCs), thereby suppressing cancer-induced neuronal hyperexcitability. Importantly, the analgesic and protective effects of NPD1 and ARU are abolished in Gpr37 −/− mice, and β-arrestin 2 is identified as a key mediator in IL-10 release and neuronal inhibition. In patients with bone metastases, plasma levels of endogenous NPD1 are negatively correlated with both pain intensity and the bone resorption marker CTX-I. Collectively, these findings highlight GPR37 activation as a potential therapeutic strategy for alleviating bone cancer pain through direct and synergistic inhibition of osteoclastogenesis and neuronal hyperexcitability.}, archive = {J_ADVS}, author = {Kaiyuan Wang and Yongfang Zhang and Ruichen Shu and Limei Yuan and Huifang Tu and Shengran Wang and Bo Ni and Yi-Fan Zhang and Changyu Jiang and Yuhui Luo and Yiqing Yin}, doi = {10.1002/advs.202417367}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2417367}, shortjournal = {Adv. Sci.}, title = {GPR37 activation alleviates bone cancer pain via the inhibition of osteoclastogenesis and neuronal hyperexcitability}, volume = {12}, year = {2025}, }
• (2025). Generation of site-specifically labeled affinity reagents via use of a self-labeling single domain antibody. ADVS, 12(14), 2417160. (www)

  @article{ , abstract = {Several chemical and enzymatic methods have been used to link antibodies to moieties that facilitate visualization of cognate targets. Emerging evidence suggests that the extent of labeling, dictated by the type of chemistry used, has a substantial impact on performance, especially in the context of antibodies used for the visualization of tumors in vivo. These effects are particularly pronounced in studies using small antibody fragments, such as single-domain antibodies, or nanobodies. Here, we leverage a new variety of conjugation chemistry, based on a nanobody that forms a crosslink with a specialized high-affinity epitope analogue, to label target-specific nanobody constructs with functionalities of choice, including fluorophores, chelators, and click chemistry handles. Using heterodimeric nanobody conjugates, comprised of an antigen recognition module and a self-labeling module, enables us to attach the desired functional group at a location distal to the site of antigen recognition. Constructs generated using this approach bound to antigens expressed on xenograft murine models of liver cancer and allowed for non-invasive diagnostic imaging. The modularity of our approach using a self-labeling nanobody offers a novel method for site-specific functionalization of biomolecules and can be extended to other applications for which covalent labeling is required.}, archive = {J_ADVS}, author = {Stanley Fayn and Swarnali Roy and Chino C. Cabalteja and Woonghee Lee and Hima Makala and Kwamena Baidoo and Divya Nambiar and Julia Sheehan-Klenk and Joon-Yong Chung and Jesse Buffington and Mitchell Ho and Freddy E. Escorcia and Ross W. Cheloha}, doi = {10.1002/advs.202417160}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2417160}, shortjournal = {Adv. Sci.}, title = {Generation of site-specifically labeled affinity reagents via use of a self-labeling single domain antibody}, volume = {12}, year = {2025}, }
• (2025). Ionic liquid-based electrolyte with multiple hydrogen bonding network enabling high-voltage stable proton batteries across wide temperature range. ADVS, 12(14), 2416931. (www)

  @article{ , abstract = {Proton batteries are strong contender for next-generation energy storage due to their high safety and rapid response. However, the narrow electrochemical window of acidic aqueous electrolytes limits their energy density and stability. Here, an ionic liquid (IL)-based electrolyte (EMImOTf-H 3 PO 4 ) containing H 3 PO 4 in polar IL solvent 1-ethyl-3-methylimidazolium trifluoromethanesulfonate (EMImOTf) is developed for stable high-voltage energy storage. H 3 PO 4 serving as a proton source interacts with both EMIm + and OTf − , forming an intricate hydrogen bonding network that effectively prevents electrolyte decomposition at high voltage. The half-cell in EMImOTf-H 3 PO 4 electrolyte and pre-protonated vanadium hexacyanoferrate (H-VHCF) cathode demonstrates a 126% improvement in Coulombic efficiency over aqueous electrolytes at a current density of 1 A g −1 . The fabricated PTCDA/MXene//EMImOTf-H 3 PO 4 //H-VHCF full battery achieves an operating voltage of 2 V at room temperature, surpassing currently reported values for proton batteries. After 30 000 cycles at 5 A g −1 , the battery retains 86.1% of its initial capacity. It delivers an energy density of 87.5 Wh kg −1 and a power density of 30.6 kW kg −1 at room temperature, and can maintain stable operation across a temperature range of 110 °C (−60 ∼ 50 °C). These findings present new possibilities for proton batteries in all-weather grid-scale energy storage applications.}, archive = {J_ADVS}, author = {Xiaoyu Dong and Zhiwei Li and Hai Xu and Zhiyuan Wu and Fanhao Meng and Shuzhi Liu and Hui Dou and Xiaogang Zhang}, doi = {10.1002/advs.202416931}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2416931}, shortjournal = {Adv. Sci.}, title = {Ionic liquid-based electrolyte with multiple hydrogen bonding network enabling high-voltage stable proton batteries across wide temperature range}, volume = {12}, year = {2025}, }
• (2025). Designing ultra-narrow-band red phosphor via oxygen vacancy engineering for transparent display application. ADVS, 12(14), 2416761. (www)

  @article{ , abstract = {Narrow-band red phosphors have been crucial in enabling energy-efficient and wide color gamut display technologies. Developing novel red phosphors with narrower FWHM and suitable positions is still an urgent demand. Herein, a nanorod-shaped Nb 2 O 5 :Pr 3+ phosphor, featuring a single ultra-narrow-band red emission at 612 nm with FWHM of only 19 nm, is reported. The single narrow-band is associated with oxygen vacancies, which can influence the electron–hole recombination energy. Besides, the intensity of PL spectra presents anti-thermal properties and achieves an unexpected 12.5-fold enhancement from 80 to 280 K. Detailed structural analyses, optical measurements, and DFT calculation are used to investigate abnormal photophysical processes. It canbe found that V O1 has the lowest E form of 0.70 eV and the electron localization area around the Pr atom enlarges and presents the biggest distortion as V O1 appears. The energy transfer from oxygen vacancies to the luminescent center accounts for the large enhancement. At last, the fabricated transparent display screen presents a transparency of 50% and high color purity (98%), and the LED device shows a large color gamut. These findings advance the understanding of the relationship between luminescent properties and oxygen vacancies, inspiring more design of narrow-band red phoshors for display applications.}, archive = {J_ADVS}, author = {Wei Wang and Yi Wei and Hang Yang and Jinxuan Sun and Fuyan Su and Hanrui Liao and Hua Zou and Mingrui Li and Guogang Li}, doi = {10.1002/advs.202416761}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2416761}, shortjournal = {Adv. Sci.}, title = {Designing ultra-narrow-band red phosphor via oxygen vacancy engineering for transparent display application}, volume = {12}, year = {2025}, }
• (2025). Single-molecule insight into α-synuclein fibril structure and mechanics modulated by chemical compounds. ADVS, 12(14), 2416721. (www)

  @article{ , abstract = {α-Syn fibrils, a key pathological hallmark of Parkinson's disease, is closely associated with disease initiation and progression. Several small molecules are found to bind or dissolve α-syn fibrils, offering potential therapeutic applications. Here, an innovative optical tweezers-based, fluorescence-combined approach is developed to probe the mechanical characteristics of α-syn fibrils at the single-molecule level. When subjected to axial stretching, local deformation within α-syn fibrils appeared at forces above 50 pN. These structural alternations occurred stepwise and are irreversible, suggesting unfolding of individual α-syn molecules or subdomains. Additionally, α-syn fibrils exhibits high heterogeneity in lateral disruption, with rupture force ranging from 50 to 500 pN. The impact of different compounds on the structure and mechanical features of α-syn fibrils is further examined. Notably, epigallocatechin gallate (EGCG) generally attenuates the rupture force of fibrils by wedging into the N-terminal polar groove and induces fibril dissociation. Conversely, copper chlorophyllin A (CCA) attaches to four different sites wrapping around the fibril core, reinforcing the stability of the fibril against rupture forces. The work offers an effective method for characterizing single-fibril properties and bridges compound-induced structural alternations with mechanical response. These insights are valuable for understanding amyloid fibril mechanics and their regulation by small molecules.}, archive = {J_ADVS}, author = {Xiang Li and Lulu Bi and Shenqing Zhang and Qianhui Xu and Wencheng Xia and Youqi Tao and Shaojuan Wu and Yanan Li and Weidong Le and Wenyan Kang and Dan Li and Bo Sun and Cong Liu}, doi = {10.1002/advs.202416721}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2416721}, shortjournal = {Adv. Sci.}, title = {Single-molecule insight into α-synuclein fibril structure and mechanics modulated by chemical compounds}, volume = {12}, year = {2025}, }
• (2025). Lung-specific mRNA delivery by ionizable lipids with defined structure-function relationship and unique protein corona feature. ADVS, 12(14), 2416525. (www)

  @article{ , abstract = {Targeted delivery of mRNA with lipid nanoparticles (LNPs) holds great potential for treating pulmonary diseases. However, the lack of rational design principles for efficient lung-homing lipids hinders the prevalence of mRNA therapeutics in this organ. Herein, the combinatorial screening with structure-function analysis is applied to rationalize the design strategy for nonpermanently charged lung-targeted ionizable lipids. It is discovered that lipids carrying N-methyl and secondary amine groups in the heads, and three tails originated from epoxyalkanes, exhibiting superior pulmonary selectivity and efficiency. Representative ionizable lipids with systematically variation in chemical structures are selected to study the well-known but still puzzling “protein corona” adsorbed on the surface of LNPs. In addition to the commonly used corona-biomarker vitronectin, other arginine-glycine-aspartic acid (RGD)-rich proteins usually involved in collagen-containing extracellular matrix, such as fibrinogen and fibronectin have also been identified to have a strong correlation with lung tropism. This work provides insight into the rational design of lung-targeting ionizable lipids and reveals a previously unreported potential function of RGD-rich proteins in the protein corona of lung-homing LNPs.}, archive = {J_ADVS}, author = {Xiaoyan He and Runyuan Wang and Yan Cao and Yan Ding and Yan Chang and Haoru Dong and Rong Xie and Guisheng Zhong and Huiying Yang and Jianfeng Li}, doi = {10.1002/advs.202416525}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2416525}, shortjournal = {Adv. Sci.}, title = {Lung-specific mRNA delivery by ionizable lipids with defined structure-function relationship and unique protein corona feature}, volume = {12}, year = {2025}, }
• (2025). Advanced microarrays as heterogeneous force-remodeling coordinator to orchestrate nuclear configuration and force-sensing mechanotransduction in stem cells. ADVS, 12(14), 2416482. (www)

  @article{ , abstract = {Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin-related force remodeling and play an important role in nuclear configuration and force-sensing mechanotransduction of stem cells. However, further exploration of the interaction between actinin complex and myosin, kinetics, and molecular mechanism of cytoskeleton structures to nucleate within the engineered stem cells is vague. An extensive comprehension of cell morphogenesis, force remodeling, and nuclear force-sensing mechanotransduction is essential to reveal the basic physical principles of cytoskeleton polymerization and force-related signaling delivery. Advanced microarrays are designed to determine heterogeneous cell morphology and cell adhesion behaviors in stem cells. The heterogeneity from the engineered microarrays is transferred into nuclei to regulate nuclear configuration and force-sensing mechanotransduction by the evaluation of Lamins, YAP, and BrdU expression. Tuning the activation of adhesion proteins and cytoskeleton nucleators to adjust heterogeneous cell mechanics may be the underlying mechanism to change nuclear force-sensing configuration in response to its physiological mechanotransduction in microarrayed stem cells.}, archive = {J_ADVS}, author = {Nana Wang and Yan Hou and Lili Lin and Shihui Xu and Kyubae Lee and Yingjun Yang and Yazhou Chen and Yachun Li and Xiuhui Wang and Yongtao Wang and Tao Chen}, doi = {10.1002/advs.202416482}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2416482}, shortjournal = {Adv. Sci.}, title = {Advanced microarrays as heterogeneous force-remodeling coordinator to orchestrate nuclear configuration and force-sensing mechanotransduction in stem cells}, volume = {12}, year = {2025}, }
• (2025). ACAT1-mediated ME2 acetylation drives chemoresistance in ovarian cancer by linking glutaminolysis to lactate production. ADVS, 12(14), 2416467. (www)

  @article{ , abstract = {Lactate derived from aerobic glycolysis is crucial for DNA damage repair and chemoresistance. Nevertheless, it is frequently noted that cancer cells depend on glutaminolysis to replenish essential metabolites. Whether and how glutaminolysis might enhance lactate production and facilitate DNA repair in cancer cells remains unknown. Here, it is shown that malate enzyme 2 (ME2), which metabolizes glutamine-derived malate to pyruvate, contributes to lactate production and chemotherapy resistance in ovarian cancer. Mechanistically, chemotherapy reduces the expression of glucose transporters and impairs glucose uptake in cancer cells. The resultant decrease in intracellular glucose levels triggers the acetylation of ME2 at lysine 156 by ACAT1, which in turn potentiates ME2 enzyme activity and facilitates lactate production from glutamine. ME2-derived lactate contributes to the development of acquired chemoresistance in cancer cells subjected to prolonged chemotherapy, primarily by facilitating the lactylation of proteins involved in homologous recombination repair. Targeting ACAT1 to inhibit ME2 acetylation effectively reduced chemoresistance in both in vitro and in vivo models. These findings underscore the significance of acetylated ME2-mediated lactate production from glutamine in chemoresistance, particularly under conditions of reduced intracellular glucose within cancer cell, thereby complementing the Warburg effect and offering new perspectives on the metabolic links to chemotherapy resistance.}, archive = {J_ADVS}, author = {Cuimiao Zheng and Hao Tan and Gang Niu and Xi Huang and Jingyi Lu and Siqi Chen and Haoyuan Li and Jiayu Zhu and Zhou Zhou and Manman Xu and Chaoyun Pan and Junxiu Liu and Jie Li}, doi = {10.1002/advs.202416467}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2416467}, shortjournal = {Adv. Sci.}, title = {ACAT1-mediated ME2 acetylation drives chemoresistance in ovarian cancer by linking glutaminolysis to lactate production}, volume = {12}, year = {2025}, }
• (2025). Cu-co dual sites tandem synergistic effect boosting neutral low concentration nitrate electroreduction to ammonia. ADVS, 12(14), 2416386. (www)

  @article{ , abstract = {Electrochemical nitrate reduction reaction (NO 3 − RR) has emerged as an alternative strategy for wastewater treatment and ammonia production in neutral low-concentration nitrate. However, the electrocatalyst faces the challenge of limited NO 3 − distribution and deficient active hydrogen (H ads ) on the catalyst surface resulting from the low concentration of NO 3 − and the difficulty of water splitting under neutral conditions. Here, a Cu-Co dual sites tandem synergistic catalysis mechanism has been proposed by doping Cu into CoP to facilitate the adsorption and conversion of NO 3 − on Cu and to accelerate the water splitting on CoP leading to the significantly high NO 3 − RR performance. The designed Cu-CoP catalyst exhibits an ammonia yield of 7.65 mg h −1 cm −2 and a Faraday efficiency of 85.1% at −1.0 V under neutral low-concentration nitrate (10 m M ), which is the highest ammonia yield in the reported data. In situ characterization and theoretical calculations confirm the tandem synergistic effect, in which the Cu site favors the adsorption and activation of NO 3 − to form NO 2 − , and concurrently modulates the electronic structure of the Co site with optimized H ads adsorption resulting in the significantly enhanced NO 3 − RR at neutral low concentration nitrate.}, archive = {J_ADVS}, author = {Wenhao Yang and Ziwei Chang and Xu Yu and Ping Wu and Ruxiang Shen and Lianzhou Wang and Xiangzhi Cui and Jianlin Shi}, doi = {10.1002/advs.202416386}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2416386}, shortjournal = {Adv. Sci.}, title = {Cu-co dual sites tandem synergistic effect boosting neutral low concentration nitrate electroreduction to ammonia}, volume = {12}, year = {2025}, }
• (2025). In situ growth of robust 2D ZIF-67 MOF in block copolymer membranes for ultrafast molecular degradation. ADVS, 12(14), 2416169. (www)

  @article{ , abstract = {Membrane-based advanced oxidation processes (AOPs) rely heavily on the configuration of membrane structures and catalysts. However, designing state-of-the-art membrane structures integrated with tailored catalysts for efficient AOPs remains a significant challenge. In this study, for the first time, hybrid membranes are constructed by the in situ growth of 2D ZIF-67 onto the nanopore walls of 3D block copolymer (BCP) membranes. These membranes feature highly tunable pore structures, leading to exceptional catalytic performance that surpasses previously reported membranes. The remarkable catalytic efficiency stems from the predominant role of the non-radical species, 1 O 2 , in catalytic degradation, combined with the integration of the high-surface-area 2D ZIF-67 and the tortuous pore structures of the BCP membranes. The resulting catalytic membranes demonstrate robust performance, achieving stable permeance of over 1800 L (m 2 ·bar·h) −1 while completely degrading dyes during long-term filtration. Notably, the degradation efficiency is maintained at 90% even when the permeance is adjusted to 3070 L (m 2 ·bar·h) −1 . Additionally, the membranes exhibit excellent resistance to both alkali and acidic environments and are unaffected by various background anions or the types of degraded molecules. This work presents a novel approach to designing advanced catalytic membranes for high-efficiency, space-confined AOPs.}, archive = {J_ADVS}, author = {Jingjing Xu and Jianyong Yu and Leiming Guo and Faxue Li and Nikos Hadjichristidis}, doi = {10.1002/advs.202416169}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2416169}, shortjournal = {Adv. Sci.}, title = {In situ growth of robust 2D ZIF-67 MOF in block copolymer membranes for ultrafast molecular degradation}, volume = {12}, year = {2025}, }
• (2025). Functional complete revascularization as determined by an optimized scoring system after revascularization: A post hoc analysis from multi-center PANDA III trial. ADVS, 12(14), 2415961. (www)

  @article{ , abstract = {Functional complete revascularization (CR) after percutaneous coronary intervention (PCI) as determined by classic residual functional SYNTAX score (c-rFSS) has been associated with improved prognosis. In this study, the c-rFSS algorithm is optimized for a novel modified rFSS (m-rFSS) and prognostic implications of this novel scoring is determined. The m-rFSS algorithm is updated for 2 clinical scenarios, i.e., 1) lesions with suboptimal functional results, and 2) angiographic diameter stenosis <50% but functionally significant stenoses, which are not scored by c-rFSS. The major outcome is a 2-year major adverse cardiac event (MACE). A total of 1,555 patients analyzable for both c-rFSS and m-rFSS are included. After calculating m-rFSS, 12.0% (187/1,555) of patients with c-rFSS-based functional CR (c-rFSS = 0) are reclassified as having m-rFSS-based incomplete revascularization (IR, m-rFSS>0); thus, 377 (21.7%) patients have c-rFSS-based functional IR whereas 524 (33.7%) has m-rFSS-based IR. Patients with m-rFSS-based functional IR (m-rFSS>0) show a significantly higher risk for major MACE outcome (20.8% vs 5.9%; adjusted hazard ratio 3.32, 95% confidence interval: 2.34–4.71) than patients with functional CR (m-rFSS = 0). The m-rFSS is more predictive of 2-year MACE than c-rFSS (difference in C-index 0.07, p < 0.001). In this study, we optimized the classic scoring algorithm to develop a novel scoring system (m-rFSS), and revascularization completeness determined by m-rFSS is markedly associated with a 2-year prognosis.}, archive = {J_ADVS}, author = {Rui Zhang and Shaoyu Wu and Qianqian Liu and Changdong Guan and Hao-Yu Wang and Sheng Yuan and Lihua Xie and Yunfei Huang and Zheng Qiao and Weida Liu and Rui Fu and Lei Feng and Chenggang Zhu and Lei Song and Dong Yin and Kefei Dou}, doi = {10.1002/advs.202415961}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415961}, shortjournal = {Adv. Sci.}, title = {Functional complete revascularization as determined by an optimized scoring system after revascularization: A post hoc analysis from multi-center PANDA III trial}, volume = {12}, year = {2025}, }
• (2025). Engineering multi-site platinum ensembles synergistically boosts catalysis. ADVS, 12(14), 2415937. (www)

  @article{ , abstract = {Engineering stable and efficient noble metal ensembles with multi-type active sites while understanding the role of each site at the atomic level remains a significant challenge in heterogeneous catalysis. Herein, a sub-nanometric Pt ensemble catalyst with a diverse array of active sites is constructed via a dual-confinement strategy, which exhibits superior activity and durability with minimal Pt loading (0.13 wt.%). Simultaneously, the roles of different Pt sites at the atomic scale are determined through in situ characterization methods and density functional theory (DFT) calculations. Specifically, Pt top sites predominantly serve as pivotal centers for O═O bond activation, whereas Pt−O−Si interfacial sites primarily govern the activation of H─OH and C─H bonds. The reactive oxygen species (O 2 − , O 2 2− , and −OH) generated from O 2 and H 2 O activation synergistically enhance formaldehyde (HCHO) oxidation and shorten the reaction pathway. This study sheds light on a better understanding and rational design of catalyst active sites via precise synthesis of multi-site ensembles or discerning the distinct contributions of various catalytic sites.}, archive = {J_ADVS}, author = {Tao Dong and Fei Xiao and Xuanning Wu and Tao Ban and Jian Ji and Biyuan Liu and Jiarui Zhang and Jiuxing Jiang and Dieqing Zhang and Weixing Yang and Gaoyuan Liu and Xin Yang and Haibao Huang}, doi = {10.1002/advs.202415937}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415937}, shortjournal = {Adv. Sci.}, title = {Engineering multi-site platinum ensembles synergistically boosts catalysis}, volume = {12}, year = {2025}, }
• (2025). Unlocking the promise of antitumor hyperthermia-immunotherapy with spiky surface topology. ADVS, 12(14), 2415868. (www)

  @article{ , abstract = {Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor in adults with high mortality rate. Recently, immunotherapy has shown great success in other tumors, however, its therapeutic effect in UM is unsatisfactory, possibly due to the insufficient immune cell infiltration and low immunogenicity of UM. Thus, an efficient therapeutic strategy to reverse the immunosuppressive tumor microenvironment is required. Herein, a PD-L1 modified hierarchical structure consisting of a magnetic Fe 3 O 4 core and spiky silica shell (MNP@Spiky/PD-L1) is developed to reverse the immunosuppressive tumor microenvironment and trigger powerful antitumor immune responses. The MNP@Spiky can induce enhanced immunogenic cell death as well as physical activation of innate immunity. First, tumor cells are disrupted directly by magnetic hyperthermia effect and released tumor-associated antigens to initiate anti-tumor immune responses. Meanwhile, the spiky surface of MNP@Spiky augmented tumor antigen uptake as well as maturation of dendritic cells through inflammasome activation. By further associating with PD-L1-targeting antibody, MNP@Spiky/PD-L1 reversed the immunosuppressive tumor microenvironment and triggered powerful antitumor immune responses. Overall, this synergistic therapeutic strategy effectively reprogramed tumor microenvironment and achieved tumor eradication, which sheds light on clinical UM immunotherapy.}, archive = {J_ADVS}, author = {Muyue Yang and Yan Yu and Tongxin Ge and Qiuyi Zhu and Ai Zhuang and Wenxing Wang and Xianqun Fan}, doi = {10.1002/advs.202415868}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415868}, shortjournal = {Adv. Sci.}, title = {Unlocking the promise of antitumor hyperthermia-immunotherapy with spiky surface topology}, volume = {12}, year = {2025}, }
• (2025). Mechanical compatibility in stitch configuration and sensor adhesion for high-fidelity pulse wave monitoring. ADVS, 12(14), 2415608. (www)

  @article{ , abstract = {Wearable electronics can achieve high-fidelity monitoring of pulse waveforms on the body surface enabling early diagnosis of cardiovascular diseases (CVDs). Textile-based wearable devices offer advantages in terms of high permeability and comfort. However, knitted strain sensors struggle to capture small-range deformation signals due to stress dissipation during friction and slip of yarns within the textiles. They are optimized for mechanical adaptability and adhesive capability. In this work, the stitch configurations of knitted structure are adjusted to optimize the energy dissipation ratio during deformation and waveform fitting performance. These electric-mechanical results enabled the selection of the most suitable knitted structure for the clinical diagnosis. On the other hand, the sensor's adhesion is optimized with respect to electrical-force-strain coupling and energy transfer efficiency at the interface between skin and sensor. The balance between the storage modulus and loss modulus are adjusted via the crosslinking degree of the polyacrylamide (PAAm) hydrogel network. As a result, the optimized knitted sensor enables stable collection of pulse waveforms from the radial and dorsalis pedis arteries. In human patient evaluations, the knitting-based strain sensor can distinguish patients with different potential CVD risks through extracted characteristic indicators.}, archive = {J_ADVS}, author = {Zhongda Chen and Jun Song and Yu Lu and Jing Zhu and Hongxu Zhu and Wenxian Du and Benhui Hu}, doi = {10.1002/advs.202415608}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415608}, shortjournal = {Adv. Sci.}, title = {Mechanical compatibility in stitch configuration and sensor adhesion for high-fidelity pulse wave monitoring}, volume = {12}, year = {2025}, }
• (2025). Cobalt single-atom intercalation in molybdenum disulfide enhances piezocatalytic and enzyodynamic activities for advanced cancer therapeutics. ADVS, 12(14), 2415485. (www)

  @article{ , abstract = {Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, piezocatalytic therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron-hole recombination, inefficient energy harvesting, and the complexities of the tumor microenvironment. In this study, sulfur vacancy-engineered cobalt (Co) single-atom doped molybdenum disulfide (SA-Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced piezoelectric effects. Specifically, the introduction of Co single atom not only induces lattice distortion and out-of-plane polarization but also leads to the formation of numerous sulfur vacancies. These changes collectively narrow the intrinsic bandgap of the material, facilitating effective separation and migration of charge carriers, and enabling efficient production of reactive oxygen species under ultrasound stimulation. Additionally, the SA-Co@MoS 2 nanoflowers demonstrate improved enzymatic activity and exhibit glutathione depletion capabilities attributed to the mixed valence states of Co, intensifying oxidative stress in tumor cells, and leading to cell cycle arrest and apoptosis, while the inactivation of glutathione peroxidase 4 induces ferroptosis. Both in vitro and in vivo results indicate that SA-Co@MoS 2 nanoflowers can significantly eliminate tumor cells. This study offers valuable insights into the exploration of single-atom doping-enhanced piezoelectric sonosensitizers for cancer treatment, potentially paving the way for advancements in the field of piezocatalytic synergistic enzyodynamic therapy.}, archive = {J_ADVS}, author = {Haomiao Bai and Sujun Ding and Yanfei Dai and Jiefu Liu and Huangjing Chen and Wei Feng and Dehong Yu and Yu Chen and Xuejun Ni}, doi = {10.1002/advs.202415485}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415485}, shortjournal = {Adv. Sci.}, title = {Cobalt single-atom intercalation in molybdenum disulfide enhances piezocatalytic and enzyodynamic activities for advanced cancer therapeutics}, volume = {12}, year = {2025}, }
• (2025). 4D assembly of time-dependent lanthanide supramolecular multicolor phosphorescence for encryption and visual sensing. ADVS, 12(14), 2415418. (www)

  @article{ , abstract = {Supramolecular dynamic room temperature phosphorescence (RTP) is the focus of current research because of its wide application in biological imaging and information anti-counterfeiting. Herein, a time-dependent supramolecular lanthanide phosphorescent 4D assembly material with multicolor luminescence including white, which is composed of 4-(4-bromophenyl)-pyridine salt derivative (G), inorganic clay (LP)/Eu complex and pyridine dicarboxylic acid (DPA) is reported. Compared with the self-assembled nanoparticle G, the lamellar assembly G/LP showed the double emission of fluorescence at 380 nm and phosphorescence at 516 nm over time. Within 60 min, the phosphorescence lifetime and the quantum yield increases from none to 7.4 ms and 27.53% respectively, achieving the time-dependent phosphorescence emission, due to the limitation of progressive stacking of LP electrostatically driven “domino effect.” Furthermore, the 4D assembly of DPA and G/LP/Eu leads to a time-resolved multicolor emission from colorless to purple to white, which is successfully applied to information multi-level logic anti-counterfeiting and efficiently antibiotic selective sensor.}, archive = {J_ADVS}, author = {Yun-Ga Wu and Wei-Lei Zhou and Yugui Qiu and Siwei Wang and Jinglin Liu and Yong Chen and Xiufang Xu and Yu Liu}, doi = {10.1002/advs.202415418}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415418}, shortjournal = {Adv. Sci.}, title = {4D assembly of time-dependent lanthanide supramolecular multicolor phosphorescence for encryption and visual sensing}, volume = {12}, year = {2025}, }
• (2025). Hybrid outer membrane vesicles with genetically engineering for treatment of implant-associated infections and relapse prevention through host immunomodulation. ADVS, 12(14), 2415379. (www)

  @article{ , abstract = {Implant-associated infections (IAIs) are refractory to elimination, and the local immunosuppressive microenvironment (IME) exacerbates therapeutic difficulties, ultimately causing persistence and relapse. Therefore, exploring immunostrengthening treatments holds great promise for reversing IME and thoroughly eradicating chronic or repetitive infections. Bacterial outer membrane vesicles (OMVs) have emerged as potential immunostimulatory candidates; however, they lack active targeting capabilities and cause non-specific inflammatory side effects. In this study, bone marrow-derived mesenchymal stem cells (BMSCs) are genetically engineered to overexpress CXCR4 and isolated cell membranes (mBMSC CXCR4 ) for hybridization with OMVs derived from Escherichia coli ( E. coli ) to produce nanovesicles (mBMSC CXCR4 @OMV). The resulting mBMSC CXCR4 @OMV nanovesicles demonstrate excellent bone marrow targeting capability and are effectively taken up by bone marrow-derived macrophages, triggering the efficient transition to pro-inflammatory M1 status through TLR/NF-κB pathway. This alteration promotes innate bactericidal capacity and antigen presentation. Subsequent activation of T and B cells and inhibition of myeloid-derived suppressor cells (MDSCs) facilitated in vivo adaptive immunity in mouse models. Additionally, mBMSC CXCR4 @OMV boosted memory B cell and bacteria-specific antibody responses. Together, these data highlight the potential of mBMSC CXCR4 @OMV to eradicate complicated IAIs and provide whole-stage protection against postsurgical relapse, thus marking a significant immunotherapeutic advancement in the post-antibiotic era.}, archive = {J_ADVS}, author = {Zhichao Wang and Mingfei Li and Wenshuai Li and Liuliang He and Long Wang and Kehan Cai and Xiao Zhao and Yazhou Chen and Daifeng Li}, doi = {10.1002/advs.202415379}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415379}, shortjournal = {Adv. Sci.}, title = {Hybrid outer membrane vesicles with genetically engineering for treatment of implant-associated infections and relapse prevention through host immunomodulation}, volume = {12}, year = {2025}, }
• (2025). Chiral switch of gadopiclenol: New standards in MRI probes. ADVS, 12(14), 2415321. (www)

  @article{ , abstract = {Magnetic Resonance Imaging (MRI) plays a vital role in the accurate diagnosis of numerous human diseases and disorders, with Gd(III)-based contrast agents (GBCAs) being used in ≈30%–40% of procedures, resulting in ≈30 million doses administered annually worldwide. The careful design of a rigid macrocyclic chelator featuring a highly hydrophilic periphery leads to the development of gadopiclenol, the first bis-hydrated Gd(III)-based MRI contrast agent, recently approved for clinical use by both the FDA and EMA. The stereochemistry of the coordinating arms is found to play a crucial role in the remarkable thermodynamic stability and inertness of the Gd(III)-complex with the RRR/SSS -stereoisomer of this heptadentate chelating agent, ensuring its safety in vivo. The exceptional stability of the most effective gadopiclenol enantiomeric pair ( RRR/SSS ), coupled with a relaxivity 2 to 3 times higher than that of currently used GBCAs, has enabled the use of reduced doses while ensuring non-inferior image contrast.}, archive = {J_ADVS}, author = {Roberta Napolitano and Nicol Guidolin and Mariangela Boccalon and Alberto Fringuello Mingo and Sonia Colombo Serra and Federica Buonsanti and Roberta Fretta and Nicola Demitri and Attila Bényei and Mauro Botta and Giovanni Battista Giovenzana and Fabio Tedoldi and Zsolt Baranyai}, doi = {10.1002/advs.202415321}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415321}, shortjournal = {Adv. Sci.}, title = {Chiral switch of gadopiclenol: New standards in MRI probes}, volume = {12}, year = {2025}, }
• (2025). Behavioral abnormalities, cognitive impairments, synaptic deficits, and gene replacement therapy in a CRISPR engineered rat model of 5p15.2 deletion associated with cri du chat syndrome. ADVS, 12(14), 2415224. (www)

  @article{ , abstract = {The Cri du Chat Syndrome (CdCS), a devastating genetic disorder caused by a deletion on chromosome 5p, faces challenges in finding effective treatments and accurate animal models. Using CRISPR-Cas9, a novel CdCS rat model with a 2q22 deletion is developed, mirroring a common genetic alteration in CdCS patients. This model exhibits pronounced deficits in social behavior, cognition, and anxiety, accompanied by neuronal abnormalities and immune dysregulation in key brain regions such as the hippocampus and medial prefrontal cortex (mPFC). The immunostaining and RNA-seq analyses provide new insights into CdCS pathogenesis, revealing inflammatory and immune processes. Importantly, it is demonstrated that early gene replacement therapy with AAV- Ctnnd2 alleviates cognitive impairments in CdCS rats, highlighting the potential for early intervention. However, the effectiveness of this therapy is confined to the early developmental stages and does not fully restore all CdCS symptoms. The findings deepen the understanding of CdCS pathogenesis and suggest promising therapeutic directions.}, archive = {J_ADVS}, author = {Jingjing Shen and Yan Wang and Yang Liu and Junying Lan and Shuang Long and Yingbo Li and Di Chen and Peng Yu and Jing Zhao and Yongjun Wang and Shali Wang and Feng Yang}, doi = {10.1002/advs.202415224}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415224}, shortjournal = {Adv. Sci.}, title = {Behavioral abnormalities, cognitive impairments, synaptic deficits, and gene replacement therapy in a CRISPR engineered rat model of 5p15.2 deletion associated with cri du chat syndrome}, volume = {12}, year = {2025}, }
• (2025). Amidoxime-functionalized sp2-carbon-conjugated covalent organic frameworks for overall photocatalytic hydrogen peroxide production. ADVS, 12(14), 2415194. (www)

  @article{ , abstract = {Cyano-functionalized sp 2 -carbon-conjugated covalent organic frameworks (CN-COFs) have been considered as promising candidates for artificial photosynthesis of hydrogen peroxide (H 2 O 2 ). Nevertheless, the performance of CN-COFs is inherently limited by constrained oxygen capture capacity, insufficient charge separation, and rapid carrier recombination. Herein, the study rationally reports a strategy for integrating amidoxime groups (AO) into a COF through one-step cyano hydrolysis process to increase photocatalytic H 2 O 2 production. Combined simulations and characterizations reveal that introducing AO groups enhances hydrophilicity, stabilizes adsorbed Oxygen (O 2 ) via hydrogen bonding, accelerates the charge separation and transfer, as well as lowers the energy barrier for oxygen reduction reaction pathway, thus achieving an unmatched H 2 O 2 production rate of 6024 µmol h −1 g −1 . Importantly, the solar-to-chemical conversion (SCC) efficiency of PTTN-AO reaches 0.61%, significantly surpassing that of natural plants (≈0.1%) and most COF-based photocatalysts. The current findings are encouraging for the molecular design of polymers for green and efficient H 2 O 2 production.}, archive = {J_ADVS}, author = {Zhiwu Yu and Fengtao Yu and Mei Xu and Shufan Feng and Jianding Qiu and Jianli Hua}, doi = {10.1002/advs.202415194}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415194}, shortjournal = {Adv. Sci.}, title = {Amidoxime-functionalized sp2-carbon-conjugated covalent organic frameworks for overall photocatalytic hydrogen peroxide production}, volume = {12}, year = {2025}, }
• (2025). Confinement-enhanced multi-wavelength photon upconversion based on Triplet–Triplet annihilation in nanostructured glassy polymers. ADVS, 12(14), 2415160. (www)

  @article{ , abstract = {Sensitized triplet–triplet annihilation photon upconversion (sTTA-UC) allows blue-shifting non-coherent low-intensity light and is potentially useful in solar-powered devices, bioimaging, 3D printing, and other applications. For technologically viable solar energy harvesting systems, solid materials that capture a large fraction of the solar spectrum and efficiently upconvert the absorbed energy must be developed. Here, it is shown that broadband-to-blue UC is possible in air-tolerant, easy-to-access, nanostructured polymers comprising a rigid hydrophilic matrix and liquid nanodroplets with dimensions on the order of tens of nanometers. The droplets contain 9,10-bis[(triisopropylsilyl)ethynyl] anthracene (TIPS-Ac) as emitter/annihilator and palladium(II) octaethyl porphyrin (PdOEP) and palladium(II) meso-tetraphenyl tetrabenzoporphine (PdTPBP) as sensitizers. The confinement of the three dyes in the liquid domains renders the various bimolecular energy transfer processes that are pivotal for the TIPS-Ac's triplet sensitization highly efficient, and the simultaneous use of multiple light harvesters with triplet energy levels resonant with the emitter/annihilator increases the absorption bandwidth to ca. 150 nm. The UC process at low power densities is most efficient when both sensitizers are simultaneously excited, thanks to their confinement in the nanodroplets, which leads to an increase in the triplet density, and therefore TTA rate and yield, optimizing the use of the harvested energy.}, archive = {J_ADVS}, author = {Xueqian Hu and Luca Pollice and Alessandra Ronchi and Marco Roccanova and Michele Mauri and Davide Lardani and Dimitri Vanhecke and Angelo Monguzzi and Christoph Weder}, doi = {10.1002/advs.202415160}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415160}, shortjournal = {Adv. Sci.}, title = {Confinement-enhanced multi-wavelength photon upconversion based on Triplet–Triplet annihilation in nanostructured glassy polymers}, volume = {12}, year = {2025}, }
• (2025). Pioneering insights into the reaction kinetics of metastable intermolecular composites based on metal fluorides: Virtually non-existent condensed phase combustion products and ultra-efficient reactivity. ADVS, 12(14), 2415073. (www)

  @article{ , abstract = {As a typical representative of Metastable intermolecular composites (MICs), the energy release of nano-thermites relying on aluminum-oxygen reaction is limited by the formation of high boiling point condensed phase products. Low pressure output performance constitutes another pivotal factor influencing their efficacy. In this work, metal fluorides BiF 3 at different scales were incorporated into nano-thermites as oxidants, thereby facilitating the tunability of the released energy. The boiling points of all resultant reaction products fall below the combustion temperature, theoretically abolishing the agglomeration of condensed-phase products, thus preventing the entrapment of active metals. Additionally, it facilitates the smooth conduction of heat flux, thereby averting losses in biphasic flow dynamics. The n-Al/n-BiF 3 system exhibits a significant amplification in reactive kinetic properties in stark contrast to the n-Al/n-Bi 2 O 3 system. The reduction in ignition threshold is ascribed to a novel reaction kinetics mechanism within the n-Al/BiF 3 system. The highly electronegative fluorine within BiF 3 corrodes the Al 2 O 3 shell, inducing a “pre-ignition” reaction. The application of Density Functional Theory (DFT) evaluations has further corroborated the n-Al/n-BiF 3 system's preeminence in electron transfer capacity between the oxidizing agent and fuel, thereby furnishing an molecular-electronic basis for its potent reactive kinetic properties.}, archive = {J_ADVS}, author = {Xuwen Liu and Jingwei Li and Shenghua Feng and Yongsheng Jia and Maocong Hu and Yingkang Yao and Jinshan Sun and Quanmin Xie and Hongqian Sang}, doi = {10.1002/advs.202415073}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2415073}, shortjournal = {Adv. Sci.}, title = {Pioneering insights into the reaction kinetics of metastable intermolecular composites based on metal fluorides: Virtually non-existent condensed phase combustion products and ultra-efficient reactivity}, volume = {12}, year = {2025}, }
• (2025). Hydrogen-associated filling-controlled mottronics within thermodynamically metastable vanadium dioxide. ADVS, 12(14), 2414991. (www)

  @article{ , abstract = {The discovery of hydrogen-associated topotactic phase modulations in correlated oxide system has emerged as a promising paradigm to explore exotic electronic states and physical functionality. Here hydrogen-induced Mott phase transitions are demonstrated for metastable VO 2 (B) toward new electron-itinerant hydrogenated phases via introducing non-equilibrium condition, delicately delivering a rich spectrum of hydrogen-associated electronic states. Of particular interest, the highly robust but reversible hydrogenated phase achievable in metastable VO 2 (B) significantly benefits protonic device applications, which is in contrast with well-known VO 2 (M1), where the metallic hydrogenated phase readily turns into insulating state with extensive hydrogen doping. Establishing correlated VO 2 at metastable status fundamentally surpasses the thermodynamic restrictions to expand the adjustability in their electronic structure, giving rise to new electronic states and a superior resistive switching of 10 2 –10 5 to the counterparts in widely-reported VO 2 (M1). Utilizing the theoretical calculations and synchrotron radiation analysis, the hydrogen-associated phase modulation in metastable VO 2 (B) is dominantly driven by band-filling-controlled orbital reconfiguration, while the concurrent structural evolution unveils a strong ion-electron-lattice coupling. The present work provides fundamentally new tuning knob for adjusting the energy landscape of electron-correlated system, advancing the rational design of unachievable electronic states in hydrogen-related equilibrium phase diagram.}, archive = {J_ADVS}, author = {Xuanchi Zhou and Yongjie Jiao and Wentian Lu and Jinjian Guo and Xiaohui Yao and Jiahui Ji and Guowei Zhou and Huihui Ji and Zhe Yuan and Xiaohong Xu}, doi = {10.1002/advs.202414991}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414991}, shortjournal = {Adv. Sci.}, title = {Hydrogen-associated filling-controlled mottronics within thermodynamically metastable vanadium dioxide}, volume = {12}, year = {2025}, }
• (2025). Excited-state structural dynamics of the cubane-type metal cluster [Cu4I4(py)4] explored by time-resolved X-ray liquidography. ADVS, 12(14), 2414970. (www)

  @article{ , abstract = {Cubane-type metal clusters respond uniquely to stimuli like light and electric potential, resulting in behaviors such as crystal-to-crystal phase transitions. While structural adaptability is known to be linked to these responses, direct experimental evidence for the associated structural changes has been missing. This study addresses this gap by examining the structural dynamics of the copper(I) iodide cubane (Cu 4 I 4 (py) 4 , py = pyridine) upon photoexcitation using time-resolved X-ray liquidography. The results reveal: 1) 100 picoseconds (ps) after excitation, two distinct excited states—the cluster-centered triplet ( 3 CC) state and the (metal+halide)-to-ligand charge transfer triplet ( 3 (M/X)LCT) state—are present; 2) the 3 (M/X)LCT state decays with an apparent time constant of 1.21 ns, primarily transitioning to the 3 CC state, with a small fraction undergoing decay to the ground state (GS); and 3) the 3 CC state eventually returns to the GS. The molecular structures, provided for these states serve as benchmarks for theoretical studies. Importantly, the 3 CC structure exhibits significant distortion in the Cu 4 I 4 core and reduced symmetry, findings that are unanticipated by previous models. This comprehensive investigation deepens the understanding of the structural transformations occurring upon photoexcitation, with a potential impact on future applications of these compounds as versatile components in photosensitive metal–organic frameworks.}, archive = {J_ADVS}, author = {Doyeong Kim and Hosung Ki and Donghwan Im and Yunbeom Lee and Seonggon Lee and Jun Heo and Seunghwan Eom and Eun Hyuk Choi and Doo-Sik Ahn and Hyotcherl Ihee}, doi = {10.1002/advs.202414970}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414970}, shortjournal = {Adv. Sci.}, title = {Excited-state structural dynamics of the cubane-type metal cluster [Cu4I4(py)4] explored by time-resolved X-ray liquidography}, volume = {12}, year = {2025}, }
• (2025). Novel cerium-based p-dopants with low parasitic absorption for improved organic devices. ADVS, 12(14), 2414959. (www)

  @article{ , abstract = {High electrical conductivity and improved charge carrier injection enabled by molecular doping are pivotal for high-performance, energy-efficient, and stable organic optoelectronic devices. Molecular doping is a key element in device design and manufacturing of active-matrix organic light-emitting diode displays, a multi-billion dollar market. However, it is an inherent feature of state-of-the-art small molecule dopants and their charge-transfer complexes to strongly absorb in the visible and near-infrared spectral range. This parasitic effect results in absorption losses, reducing the performance in light-harvesting and light-emitting applications. Here, a novel class of vacuum-processable cerium-based p-dopants with excellent processing properties and competitive doping strength even in organic hole transport layers with low-lying valence levels is presented. A substantial reduction in parasitic absorption for layers doped by the new dopants in the visible and near-infrared range is found. The reduced polaron absorption of the dopant anions is in excellent agreement with theoretical simulations. By incorporating these dopants into near-infrared narrowband organic photodetectors, the specific detectivity can be increased by one order of magnitude compared to devices with the established dopant 1,3,4,5,7,8-hexafluorotetracyanonaphthoquinodimethane (F 6 -TCNNQ). The decreased parasitic absorption yields optical-microcavity-enhanced photodetectors with significantly reduced full-width at half maximum, paving the way toward more efficient and wavelength-selective infrared detectors.}, archive = {J_ADVS}, author = {Stephanie A. Buchholtz and L. Conrad Winkler and Maximilian F. X. Dorfner and Fred Kretschmer and Anncharlott Kusber and Léonard Y. M. Eymann and Theresa Schmidt and Hans Kleemann and Johannes Benduhn and Frank Ortmann and Karl Leo}, doi = {10.1002/advs.202414959}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414959}, shortjournal = {Adv. Sci.}, title = {Novel cerium-based p-dopants with low parasitic absorption for improved organic devices}, volume = {12}, year = {2025}, }
• (2025). Disturbing Cholesterol/Sphingolipid metabolism by squalene epoxidase arises crizotinib hepatotoxicity. ADVS, 12(14), 2414923. (www)

  @article{ , abstract = {Metabolic disorders have been identified as one of the causes of drug-induced liver injury; however, the direct regulatory mechanism regarding this disorder has not yet been clarified. In this study, a single regulatory mechanism of small molecule kinase inhibitors, with crizotinib as the representative drug is elucidated. First, it is discovered that crizotinib induced aberrant lipid metabolism and apoptosis in the liver. A mechanistic study revealed that crizotinib treatment promoted the accumulation of squalene epoxidase (SQLE) by inhibiting autophagosome-lysosome fusion which blocked the autophagic degradation of SQLE. A maladaptive increase in SQLE led to disturbances in cholesterol and sphingolipid metabolism via an enzymatic activity-dependent manner. Abnormal cholesterol results in both steatosis and inflammatory infiltration, and disturbances in sphingolipid metabolism promote cell apoptosis by inducing lysosomal membrane permeabilization. The restoration of the level or activity of SQLE ameliorated steatosis and hepatocyte injury. The autophagy activator known as metformin or the SQLE enzymatic inhibitor known as terbinafine has potential clinical use for alleviating crizotinib hepatotoxicity.}, archive = {J_ADVS}, author = {Hao Yan and Xiangliang Huang and Yourong Zhou and Yuan Mu and Shaoyin Zhang and Yashi Cao and Wentong Wu and Zhifei Xu and Xueqin Chen and Xiaochen Zhang and Xiaohong Wang and Xiaochun Yang and Bo Yang and Qiaojun He and Peihua Luo}, doi = {10.1002/advs.202414923}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414923}, shortjournal = {Adv. Sci.}, title = {Disturbing Cholesterol/Sphingolipid metabolism by squalene epoxidase arises crizotinib hepatotoxicity}, volume = {12}, year = {2025}, }
• (2025). Therapeutic black phosphorus nanosheets elicit neutrophil response for enhanced tumor suppression. ADVS, 12(14), 2414779. (www)

  @article{ , abstract = {Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions in cancer treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol-functionalized BP (BP-PEG) nanosheets in breast cancer models. Using immunocompetent mouse models-including 4T1 orthotopic BALB/c mice and MMTV-PyMT transgenic mice, it is found that BP-PEG significantly inhibits tumor growth and metastasis without directly inducing cytotoxicity in tumor cells. Mass cytometry analysis reveals that BP-PEG reshapes the tumor immune microenvironment by recruiting neutrophils. Neutrophil depletion experiments further demonstrate that the antitumor effects of BP-PEG are dependent on neutrophils. Moreover, bulk and single-cell RNA sequencing indicate that BP-PEG is mainly taken up by macrophages, leading to the release of inflammatory factors such as IL1A and CXCL2, which enhance neutrophil recruitment and activation, thereby amplifying the antitumor immune response. Finally, co-culture assays confirm that BP-PEG indeed enhances the antitumor activity of neutrophils and natural killer (NK) cells. These findings position BP-PEG as an immunomodulatory agent capable of reprogramming the tumor microenvironment to promote innate immunity against breast cancer. By stimulating neutrophil-mediated antitumor activity, BP-PEG offers a unique therapeutic approach that can potentially enhance the efficacy of existing cancer immunotherapies.}, archive = {J_ADVS}, author = {Jing Wang and Weiqiang Yu and Hui Shen and Yanxiang Sang and Hongjie Zhang and Benyan Zheng and Xue Peng and Yuan Hu and Xiaopeng Ma and Zhenye Yang and Fazhi Yu}, doi = {10.1002/advs.202414779}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414779}, shortjournal = {Adv. Sci.}, title = {Therapeutic black phosphorus nanosheets elicit neutrophil response for enhanced tumor suppression}, volume = {12}, year = {2025}, }
• (2025). Fam172a mediates the stimulation of hypothalamic oxytocin neurons to suppress obesity-induced anxiety. ADVS, 12(14), 2414723. (www)

  @article{ , abstract = {Anxiety disorder is the most common mental disorder worldwide. Although human studies have demonstrated a positive association between obesity and anxiety disorder, the exact mechanism linking these conditions is unclear. Interestingly, oxytocin (Oxt) neurons, predominantly expressed in the hypothalamic paraventricular nucleus (PVN), play a crucial role in both obesity and anxiety. In this study, obesity can induce anxiety-like behavior in mice, which can be ameliorated by the activation of PVN Oxt neurons. Conversely, inhibiting PVN Oxt neurons accelerate the progression of anxiety. Moreover, the family with sequence similarity 172, member A (Fam172a), an anxiety susceptibility gene, is highly expressed in the hypothalamic PVN Oxt neuron but reduce in the PVN Oxt neuron of mice in the high-fat diet and acute restraint stress conditions. Significantly, overexpression of Fam172a in PVN Oxt neurons improve obesity-anxiety-like behavior in mice. In contrast, disruption of Fam172a in PVN Oxt neurons exacerbate obesity-anxiety-like behavior. Furthermore, this study demonstrates that Fam172a is involved in mRNA degradation in Oxt neurons by regulating the intranuclear transport of Argonaute 2, thereby influencing Oxt secretion and ultimately impacting obesity-anxiety-like behavior. These findings suggest that Fam172a serves as a key target of PVN Oxt neurons in the regulation of obesity-induced anxiety.}, archive = {J_ADVS}, author = {Baocheng Wan and Lina Zhang and Xinyu Wang and Rong Zhang and Lianxi Li and Yi Zhang and Zhuo Chen and Cheng Hu}, doi = {10.1002/advs.202414723}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414723}, shortjournal = {Adv. Sci.}, title = {Fam172a mediates the stimulation of hypothalamic oxytocin neurons to suppress obesity-induced anxiety}, volume = {12}, year = {2025}, }
• (2025). Rapid and differential diagnosis of sepsis stages using an advanced 3D plasmonic bimetallic alloy nanoarchitecture-based SERS biosensor combined with machine learning for multiple analyte identification. ADVS, 12(14), 2414688. (www)

  @article{ , abstract = {Rapid and accurate differential diagnosis of infections, sepsis, and septic shock is essential for preventing unnecessary antibiotic overuse and improving the chance of patient survival. To address this, a 3D gold nanogranule decorated gold-silver alloy nanopillar (AuNG@Au-AgNP) based surface-enhanced Raman scattering (SERS) biosensor is developed, capable of quantitatively profiling immune-related soluble proteins (interleukin three receptor, alpha chain: CD123, programmed cell death ligand 1: PD-L1, human leukocyte antigen–DR isotype: HLA-DR, and chitotriosidase: ChiT) in serum samples. The 3D bimetallic nanoarchitecture, fabricated using anodized aluminum oxide (AAO), features a uniform structure with densely packed nanogaps on the heads of Au-Ag alloy nanopillars, enabling fast, simple, and replicable production. The proposed biosensor achieves accurate results even with low detection limits (4–6 fM) and high signal consistency (relative standard deviation (RSD) = 1.79%) within a one-step multi-analytes identification chip with a directly loadable chamber. To enhance the diagnostic performance, a support vector machine (SVM) based machine learning algorithm is utilized, achieving 95.0% accuracy and 95.8% precision in classifying healthy controls, infections with and without sepsis, and septic shock. This advanced 3D plasmonic bimetallic alloy nanoarchitecture-based SERS biosensor demonstrates clinical usefulness for sepsis diagnosis and severity assessment, providing timely and personalized treatment.}, archive = {J_ADVS}, author = {Woo Hyun Kim and Sungwoo Lee and Myeong Jin Jeon and Kwon Jun Lee and Jong-Hak Park and Dae Won Park and Sungho Park and Sang Jun Sim}, doi = {10.1002/advs.202414688}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414688}, shortjournal = {Adv. Sci.}, title = {Rapid and differential diagnosis of sepsis stages using an advanced 3D plasmonic bimetallic alloy nanoarchitecture-based SERS biosensor combined with machine learning for multiple analyte identification}, volume = {12}, year = {2025}, }
• (2025). Electrically-shielded coil-enabled battery-free wireless sensing for underwater environmental monitoring. ADVS, 12(14), 2414299. (www)

  @article{ , abstract = {Battery-free wireless sensing in extreme environments, such as conductive solutions, is crucial for long-term, maintenance-free monitoring, eliminating the limitations of battery power and enhancing durability in hard-to-reach areas. However, in such environments, the efficiency of wireless power transfer via radio frequecny (RF) energy harvesting is heavily compromised by signal attenuation and environmental interference, which degrade antenna quality factors and detune resonance frequencies. These limitations create substantial challenges in wirelessly powering miniaturized sensor nodes for underwater environmental monitoring. To overcome these challenges, electrically-shielded coils with coaxially aligned dual-layer conductors are introduced that confine the electric field within the coil's inner capacitance. This configuration mitigates electric field interaction with the surrounding medium, making the coils ideal for use as near-field antennas in aquatic applications. Leveraging these electrically-shielded coils, a metamaterial-enhanced reader antenna was developed and a 3-axis sensor antenna for an near-field communication (NFC)-based system. The system demonstrated improved spectral stability, preserving resonance frequency and maintaining a high-quality factor. This advancement enabled the creation of a battery-free wireless sensing platform for real-time environmental monitoring in underwater environments, even in highly conductive saltwater with salinity levels of up to 3.5%.}, archive = {J_ADVS}, author = {Ke Wu and Xia Zhu and Stephan W. Anderson and Xin Zhang}, doi = {10.1002/advs.202414299}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414299}, shortjournal = {Adv. Sci.}, title = {Electrically-shielded coil-enabled battery-free wireless sensing for underwater environmental monitoring}, volume = {12}, year = {2025}, }
• (2025). Human pituitary organoids: Transcriptional landscape deciphered by scRNA-seq and stereo-seq, with insights into SOX3's role in pituitary development. ADVS, 12(14), 2414230. (www)

  @article{ , abstract = {The 3D human pituitary organoid represents a promising laboratory model for investigating human pituitary diseases. Nonetheless, this technology is still in its nascent stage, with uncertainties regarding the cellular composition, intercellular interactions, and spatial distribution of the human pituitary organoids. To address these gaps, the culture conditions are systematically adjusted and the efficiency of induced pluripotent stem cells’ (iPSCs’) differentiation into pituitary organoids is successfully improved, achieving results comparable to or exceeding those of previous studies. Additionally, single-cell RNA-sequencing (scRNA-seq) and stereomics sequencing (Stereo-seq) are performed on the pituitary organoids for the first time, and unveil the diverse cell clusters, intricate intercellular interactions, and spatial information within the organoids. Furthermore, the SOX3 gene interference impedes the iPSCs’ differentiation into pituitary organoids, thereby highlighting the potential of pituitary organoids as an ideal experimental model. Altogether, the research provides an optimized protocol for the human pituitary organoid culture and a valuable transcriptomic dataset for future explorations, laying the foundation for subsequent research in the field of pituitary organoids or pituitary diseases.}, archive = {J_ADVS}, author = {Shengjie Wang and Deyue Jiang and Yan Xiao and Qiaozhen Qin and Heyang Zhang and Lingtong Ye and Jide Jin and Xiaoxia Jiang and Qinghua Guo}, doi = {10.1002/advs.202414230}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414230}, shortjournal = {Adv. Sci.}, title = {Human pituitary organoids: Transcriptional landscape deciphered by scRNA-seq and stereo-seq, with insights into SOX3's role in pituitary development}, volume = {12}, year = {2025}, }
• (2025). Transformable tumor microenvironment-responsive oxygen vacancy-rich MnO2@Hydroxyapatite nanospheres for highly efficient cancer sonodynamic immunotherapy. ADVS, 12(14), 2414162. (www)

  @article{ , abstract = {Despite the promise of sonodynamic therapy (SDT)-mediated immunotherapy, the anticancer efficacy of current sonosensitizers is greatly limited by the immunosuppressive tumor microenvironment (TME) and their inability to selectively respond to it. Herein, oxygen vacancy-rich MnO 2 @hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) core–shell nanospheres (denoted as O v -MO@CPO) as an advanced TME-responsive sonosensitizer for sonodynamic immunotherapy is demonstrated. The O v -MO@CPO maintains its structural integrity under neutral conditions but dissolves the pH-sensitive hydroxyapatite shell under acidic TME to release active oxygen vacancy-rich MnO 2 core, which reinvigorates H 2 O 2 consumption and hypoxia alleviation due to its catalase-like activity. Furthermore, the introduced oxygen vacancies optimize the electronic structure of O v -MO@CPO, with active electronic states near the Fermi level and higher d-band center. It results in accelerated electron-hole pair separation and lower catalytic energy barriers to boost ultrasound (US)-initiated ROS production. These multimodal synergistic effects effectively reverse the immunosuppressive tumor microenvironment, inhibiting tumor growth and metastasis in 4T1 tumor-bearing mice. No evident toxic effects are observed in normal mouse tissues. Additionally, when combined with an immune checkpoint inhibitor, O v -MO@CPO-mediated SDT further improves the effectiveness of immunotherapy. This work affords a new avenue for developing TME-dependent sonosensitizers for SDT-mediated immunotherapy.}, archive = {J_ADVS}, author = {Minxing Li and Qiyu Liu and Songzuo Xie and Desheng Weng and Jinjun He and Xinyi Yang and Yuanyuan Liu and Jinqi You and Jinghao Liao and Peng Wang and Xihong Lu and Jingjing Zhao}, doi = {10.1002/advs.202414162}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2414162}, shortjournal = {Adv. Sci.}, title = {Transformable tumor microenvironment-responsive oxygen vacancy-rich MnO2@Hydroxyapatite nanospheres for highly efficient cancer sonodynamic immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Linking metastatic behavior and metabolic heterogeneity of circulating tumor cells at single-cell level using an integrative microfluidic system. ADVS, 12(14), 2413978. (www)

  @article{ , abstract = {Circulating tumor cells (CTCs) are pivotal biomarkers in tumor metastasis, however, the underlying molecular mechanism of CTCs behavioral heterogeneity during metastasis remains unexplored. Here, an integrative workflow is developed to link behavior characteristics to metabolic profiling within individual CTCs, which simulates the metastatic process on a microfluidic system and combined with single-cell mass spectrometry (MS) detection. Spheroid-derived HCT116 cells are tracked and extracted via a temporary vascular system, revealing various arrest patterns under biomimetic vascular shear flow. Downstream MS analysis characterizes 17 cellular metabolites and associates metabolic profiles with de-adhesion behaviors of the same CTCs, identifying a potential high-metastatic subpopulation with enhanced arrest ability and evaluating critical metabolites involved in metastasis pathways. Additionally, the metastasis-inhibiting effect of anti-tumor drug 5-fluorouracil by reducing high-metastatic cells in spheroids is elucidated. This approach offers a valuable opportunity to dissect the interplay of the metastatic behavior and metabolic profiles of CTCs and foster insights into the molecular mechanisms underlying behavioral phenotypes in the tumor metastasis process.}, archive = {J_ADVS}, author = {Ying Hou and Jiaxu Lin and Hongren Yao and Zengnan Wu and Yongning Lin and Jin-Ming Lin}, doi = {10.1002/advs.202413978}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413978}, shortjournal = {Adv. Sci.}, title = {Linking metastatic behavior and metabolic heterogeneity of circulating tumor cells at single-cell level using an integrative microfluidic system}, volume = {12}, year = {2025}, }
• (2025). Leveraging tumor microenvironment to boost synergistic photodynamic therapy, ferroptosis anti-tumor efficiency based on a functional Iridium(III) complex. ADVS, 12(14), 2413879. (www)

  @article{ , abstract = {The tumor microenvironment (TME) severely limits the efficacy of clinical applications of photodynamic therapy (PDT). The development of a functional agent allowing full use of the TME to boost synergistic PDT and ferroptosis anti-tumor efficiency is an appealing yet significantly challenging task. Herein, to overcome the adverse influence on PDT of hypoxia and high level of glutathione (GSH) in the TME, an imine bond is introduced into an Ir(III)-ferrocene complex to construct a small molecule drug, named Ir-Fc, for tumors’ imaging and therapy. The cleavage of the imine bond in the lysosome effectively disrupts the photoinduced electron transfer (PET) process, realizing the decomposition of Ir-Fc into Fc-CHO and Ir-NH 2 . Fc-CHO produces •OH by Fenton reactions under dark conditions and induces ferroptosis in tumor cells, and Ir-NH 2 shows prominent performance for type-I and type-II reactive oxygen species (ROS) production. Meanwhile, the ferroptosis pathway simultaneously consumes large amounts of GSH and produces O 2 for effectively relieving hypoxia. These distinctive outputs make Ir-Fc an exceptional molecule for effective tumor synergistic therapy. This study thus brings a new and revolutionary PDT protocol for practical cancer treatment.}, archive = {J_ADVS}, author = {Yu Pei and Yinzhen Pan and Zhijun Zhang and Jun Zhu and Yan Sun and Qian Zhang and Dongxia Zhu and Guangzhe Li and Martin R. Bryce and Dong Wang and Ben Zhong Tang}, doi = {10.1002/advs.202413879}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413879}, shortjournal = {Adv. Sci.}, title = {Leveraging tumor microenvironment to boost synergistic photodynamic therapy, ferroptosis anti-tumor efficiency based on a functional Iridium(III) complex}, volume = {12}, year = {2025}, }
• (2025). Integrating competitive li+ coordination with immobilized anions in composite solid electrolyte for high-performance li metal batteries. ADVS, 12(14), 2413875. (www)

  @article{ , abstract = {Poly(vinylidene fluoride) (PVDF)-based polymer electrolytes have attracted widespread attention due to their unique Li + transport mechanism. However, their low ionic conductivity and porous structure, as well as residual solvent limit their application at high current densities. Here, a composite solid electrolyte (CSE) is developed by integrating poly(vinylidene-co-trifluoroethylene) [P(VDF-TrFE)] in its all-trans conformation with aminofunctionalized metal–organic framework (ZIF-90-NH 2 ). In such a CSE, all F atoms located on one side of the polymer chain, providing fast Li + transport channels. Concurrently, the functionalized ZIF-90-NH 2 can effectively anchor the residual N, N-dimethylformamide (DMF) in CSEs while weakening Li + -DMF solvent coordination, inducing the rearrangement of Li + solvation structure and inhibiting the decomposition of DMF at the interface. Synergistically, ZIF-90-NH 2 can immobilize anions in Li salts, promoting their dissociation. Based on integrating competitive Li + coordination with immobilized anions, the obtained CSEs exhibit a high Li + transference number (0.77). The full cells with LiFePO 4 cathode can run stably over 400 cycles at 5 C, while the Li || LiNi 0.7 Co 0.1 Mn 0.2 O 2 full cells deliver a high capacity retention (>85%) after 200 cycles at a charge cutoff voltage of 4.5 V. This work opens up a new path for building CSEs with high interfacial stability and fast Li + transport.}, archive = {J_ADVS}, author = {Ziyang Liang and Chang Liu and Xiang Bai and Jiahui Zhang and Xinyue Chang and Bo Zhang and Mengxue Xia and Huayun Du and Hao Huang and Bing Wu and Chengkai Yang and Shi Wang and Wen Liu and Qian Wang}, doi = {10.1002/advs.202413875}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413875}, shortjournal = {Adv. Sci.}, title = {Integrating competitive li+ coordination with immobilized anions in composite solid electrolyte for high-performance li metal batteries}, volume = {12}, year = {2025}, }
• (2025). Chalcogenide metasurfaces enabling ultra-wideband detectors from visible to mid-infrared. ADVS, 12(14), 2413858. (www)

  @article{ , abstract = {Thermoelectric materials can be designed to support optical resonances across multiple spectral ranges to enable ultra-wideband photodetection. For instance, antimony telluride (Sb 2 Te 3 ) chalcogenide exhibits interband plasmonic resonances in the visible range and Mie resonances in the mid-infrared (mid-IR) range, while simultaneously possessing large thermoelectric Seebeck coefficients of 178 µV K −1 . However, chalcogenide metasurfaces for achieving miniaturized and wavelength-sensitive ultra-wideband detectors have not been explored so far, especially with a single material platform. In this paper, Sb 2 Te 3 metasurface devices are designed and fabricated to achieve ≈97% resonant absorption for enabling photodetectors operating across an ultra-wideband spectrum, from visible to mid-IR. Furthermore, relying on linear polarization-sensitive Sb 2 Te 3 metasurface, the thermoelectric photodetectors with linear polarization-selectivity are demonstrated. This work provides a potential platform toward the portable ultrawide band spectrometers without requiring cryogenic cooling, for environmental sensing applications.}, archive = {J_ADVS}, author = {Shutao Zhang and Shu An and Mingjin Dai and Qing Yang Steve Wu and Nur Qalishah Adanan and Jun Zhang and Yan Liu and Henry Yit Loong Lee and Nancy Lai Mun Wong and Ady Suwardi and Jun Ding and Robert Edward Simpson and Qi Jie Wang and Joel K. W. Yang and Zhaogang Dong}, doi = {10.1002/advs.202413858}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413858}, shortjournal = {Adv. Sci.}, title = {Chalcogenide metasurfaces enabling ultra-wideband detectors from visible to mid-infrared}, volume = {12}, year = {2025}, }
• (2025). Ultrafast all-optical switching and active sub-cycle waveform control via time-variant photodoping of terahertz metasurfaces. ADVS, 12(14), 2413719. (www)

  @article{ , abstract = {The development of high-speed and high-performance optical switches has been a long-standing issue in the field of photonics. This paper introduces a pioneering time-resolved spectroscopy-based approach for realizing photon-induced ultrafast terahertz (THz) modulation within an electrical split-ring resonator (SRR) via photoexcitation, rather than relaxation dynamics, in a silicon-based indirect-bandgap material. Two competitive effects (shorting of LC circuit and metallization of substrate) occur during photon-induced THz modulation. The tradeoff between these two effects enables high-speed optical switching via different time scales of the photoexcitation processes—THz-optical cooperative effect and phonon-assisted electron transition. THz-optical cooperative photoexcitation, causing a shorting effect within the LC circuit, has been observed in the SRR gap, whose size typically exceeds that facilitating impact ionization (IMI). Notably, a remarkably short THz switching time of 1.3 ps has been achieved via only photoexcitation and with a high-performance transmission intensity modulation depth of over 500%. In addition, active temporal waveform control down to a sub-cycle pulse has been successfully demonstrated. The proposed approach suggests a new route for constructing high-speed and efficient THz dynamic photonic devices with potential applications in temporal waveform control.}, archive = {J_ADVS}, author = {Jeongmin Jang and Junsuk Rho and Hee Jun Shin}, doi = {10.1002/advs.202413719}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413719}, shortjournal = {Adv. Sci.}, title = {Ultrafast all-optical switching and active sub-cycle waveform control via time-variant photodoping of terahertz metasurfaces}, volume = {12}, year = {2025}, }
• (2025). Reprogramming lung redox homeostasis by NIR driven ultra-small pd loaded covalent organic framework inhibits NF-κB pathway for acute lung injury immunotherapy. ADVS, 12(14), 2413697. (www)

  @article{ , abstract = {Acute lung injury (ALI) refers to damage to lung related cells, typically caused by an uncontrollable inflammatory response, and over-generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming lung redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, the simple synthesis of ultra-small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities and broad spectrum ROS scavenging, thereby promoting tissue repair for ALI immunotherapy. Mechanistically, through the therapeutic strategy of TP@Pd+NIR, the damaged cells and tissues are ameliorated by decreasing intracellular ROS levels (total ROS, ·OH and ·O 2 − ), downregulating inflammatory cytokines levels (IL-6, TNF-α and IL-1β), upregulating antioxidant factor level (SOD2), inducing macrophage M2 directional polarization (downregulation of iNOS and CD86, and upregulation of IL-10 and CD206), activating immunoregulation (CD4 + /CD8 + ratio increase), promoting tissue repair factor levels (upregulation of HSP70 and CD31), and suppressing the NF-κB signaling pathway (downregulation of phosphorylated p65 and IκBα). Furthermore, following intravenous (IV) injection in rats, TP@Pd accumulated in lung tissue for 6 h, indicating the promising therapeutic efficacy via this administration route. Notably, the TP@Pd+NIR strategy demonstrated the excellent synergistic effects in alleviating lung inflammation storms, reducing diffuse alveolar damage, and accelerating lung tissue repair. Summarily, this work has designed a novel TP@Pd+NIR strategy for the synergistic enhancement of ALI amelioration, which may serve as a promising therapeutic approach for other ROS related diseases.}, archive = {J_ADVS}, author = {Doudou Lei and Lin Liao and Tao Qin and Xiaoxuan Guan and Kunpeng Duan and Zhiwei Gao and Weiqian Jin and Mingjing Yin and Ke Zhang and Yan Liu and Yin Chen and Huyang Gao and Jiaxiao Li and Feifei Huang and Wenjing Liu and Chengde Xia and Bailei Wang and Hualin Huang and Shengqiu Lv and Qiang Zhi and Jiahao Huang and Ming Gao and Junyu Lu}, doi = {10.1002/advs.202413697}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413697}, shortjournal = {Adv. Sci.}, title = {Reprogramming lung redox homeostasis by NIR driven ultra-small pd loaded covalent organic framework inhibits NF-κB pathway for acute lung injury immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Biomimetic pyramid structure film for enhancing building radiative cooling. ADVS, 12(14), 2413559. (www)

  @article{ , abstract = {Radiative cooling has emerged as a promising technique for reducing energy consumption in building thermal management due to its passive cooling property and no external energy requirement. Despite significant advances, scalable production of artificial photonic radiators with periodic structures, environmental stability, high radiative cooling performance, and economic applicability is still challenging in most state-of-the-art radiative coolers. Rational structure and materials design are essential to promote daytime sunlight reflectance while maintaining a high emissivity within the atmospheric window (8–13 µm). In this work, inspired from the unique hair structure of heat-resistant organisms, a biomimetic micro-pyramid shaped structure model is analyzed. By mimicking the intricate design with a silicon template, a radiative cooling film containing specialized micro-pyramid structure is fabricated by integrating high dielectric constant materials with polymers and receiving PVDF coating. The resulting film boasts a solar reflectance of 97.3% and an exceeding 98% infrared light emission within the atmospheric window. In addition, silicon rubber endows this membrane with strong tensile and rebound properties while surficial hydrophobicity protects the membrane from dust infestation. Considering the manufacturing simplicity and cost-effectiveness, this method shows great potential for mass production, shedding light on building thermal management.}, archive = {J_ADVS}, author = {Qian-Hao Pan and Mei-Hua Wang and Zong-Ying Huang and Xiao-Jing Qiu and Yu-Tao Wang and Fu-Xing Zhao and Meng-Han Zhu and Xin Guo and Chen Chen and Si-Chao Zhang and Jin-Long Wang and Zhen He and Shu-Hong Yu}, doi = {10.1002/advs.202413559}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413559}, shortjournal = {Adv. Sci.}, title = {Biomimetic pyramid structure film for enhancing building radiative cooling}, volume = {12}, year = {2025}, }
• (2025). LINC01235 promotes clonal evolution through DNA replication licensing-induced chromosomal instability in breast cancer. ADVS, 12(14), 2413527. (www)

  @article{ , abstract = {Despite the development of HER2-targeting drugs such as trastuzumab and T-DXd, treatment resistance is a substantial challenge, often leading to relapse and distant metastasis. Tumor heterogeneity in HER2-positive breast cancer drives the evolution of resistant clones following therapeutic stress. However, the targetable drivers of anti-HER2 treatment resistance are not thoroughly identified. This study aims to use neoadjuvant-targeted therapy cohorts and a patient-derived organoid in vitro treatment model to uncover the potential targetable drivers of anti-HER2 treatment resistance. it is found that LINC01235 significantly enhances DNA replication licensing and chromosomal instability, fostering clonal expansion and evolution, and ultimately increasing resistance to therapeutic interventions. LINC01235 regulates global H3K27ac, H3K9ac, and H3K36me3 modifications, promotes H2A.Z expression in regulatory regions, and increases the accessibility of DNA licensing factors to their promoter regions. XRCC5 is identified as a key component for maintaining genomic stability, crucial for LINC01235's role in replication licensing. Furthermore, therapeutic strategies targeting LINC01235, including the use of antisense oligonucleotides or ATR inhibitors, which showed promise in overcoming treatment resistance are explored. These findings underscore the pivotal role of LINC01235 in driving resistance mechanisms and highlight novel avenues for targeted therapies to improve the outcomes of patients with HER2-positive breast cancer.}, archive = {J_ADVS}, author = {Qi Zhang and Xuliren Wang and Zhibo Shao and Yi Zhang and Liyi Zhang and Ming Chen and Xujie Zhou and Han Zhu and Yue Zhou and Xinya Lu and Pei Li and Weiru Chi and Lun Li and Zhi-Ming Shao and Shenglin Huang and Jingyan Xue and Yayun Chi and Jiong Wu and Bingqiu Xiu}, doi = {10.1002/advs.202413527}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413527}, shortjournal = {Adv. Sci.}, title = {LINC01235 promotes clonal evolution through DNA replication licensing-induced chromosomal instability in breast cancer}, volume = {12}, year = {2025}, }
• (2025). Nuclear to cytoplasmic transport is a druggable dependency in HDAC7-driven small cell lung cancer. ADVS, 12(14), 2413445. (www)

  @article{ , abstract = {Immunotherapy has gained approval for use in small cell lung cancer (SCLC), yet only a subset of patients (10–20%) experience meaningful benefits, underscoring the urgent need for more effective therapeutic approaches. This work discovers a distinct HDAC7-high SCLC phenotype characterized by enhanced proliferative potential, which recurs across various subtypes and serves as a predictor of poorer survival outcomes. By analyzing public datasets, this work finds a strong correlation between c-Myc and HDAC7. RNA sequencing and cellular experiments show that XPO1 is a key regulator in the HDAC7/c-Myc axis. HDAC7 promotes β-catenin deacetylation, phosphorylation modulation, nuclear translocation, and formation of the β-catenin/TCF/LEF1 complex, which binds to c-Myc and XPO1 promoters. Activation of the HDAC7/β-catenin pathway upregulates c-Myc and XPO1 expression, while c-Myc also boosts XPO1 expression. Given the difficulty in targeting c-Myc directly, this work tests selinexor and vorinostat in SCLC xenograft models, with selinexor showing superior results. High HDAC7 expression is linked to increased SCLC proliferation, poorer prognosis, and enhanced sensitivity to selinexor in SCLC cell lines and organoid models. Collectively, this work uncovers a novel HDAC7/c-Myc/XPO1 signaling axis that promotes SCLC progression, suggesting that HDAC7 may warrant further investigation as a potential biomarker for assessing selinexor sensitivity in SCLC patients.}, archive = {J_ADVS}, author = {Tingting Qin and Jingya Wang and Jian Wang and Qingwu Du and Liuchun Wang and Hailin Liu and Wenting Liu and Xueyang Li and Yantao Jiang and Qi Xu and Junjie Yu and Huiyan Liu and Ting Wang and Mengjie Li and Dingzhi Huang}, doi = {10.1002/advs.202413445}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413445}, shortjournal = {Adv. Sci.}, title = {Nuclear to cytoplasmic transport is a druggable dependency in HDAC7-driven small cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). Force-triggered non-volatile multilevel mechano-optical memory system for logic computation and image recognition. ADVS, 12(14), 2413409. (www)

  @article{ , abstract = {In the big data era, sensing multi-modal information in memory is highly demanded for the sake of artificial intelligence applications to overcome the limitations of the von Neumann architecture. Different from traditional sensing methodologies, mechanoluminescence (ML) materials, which emit light in response to mechanical force without any external power supply, present intriguing prospects for technological developments. However, most of the ML materials only demonstrate instantaneous luminescence, severely hampering the exploitation of ML in sophisticated applications where non-volatile control is indispensable. Herein, a non-volatile, multilevel mechano-optical memory system is proposed, based on a crafted combination of a self-recoverable ML material, ZnS:Cu, and a photostimulated luminescence (PSL) phosphor Ca 0.25 Sr 0.75 S:Eu (CaSrS:Eu). By integrating ML with PSL effect, a robust six-level non-volatile memory is achieved, in which the multilevel memory states allow for computational capability without electrical interference. Specifically, the reliable multilevel and non-volatile response enables Boolean logic operations. Furthermore, neuromorphic visual pattern pre-processing is implemented, resulting in a substantial increase in recognition accuracy from 20% to 80%. These findings endow force-responsive phosphors with memory capability, fully leveraging the capabilities of ML and offering a new strategy for developing mechano-optical hardware and concepts for future intelligent applications.}, archive = {J_ADVS}, author = {Jiaxing Guo and Feng Guo and Hang Yang and Tianhong Zhou and Xiaona Du and Rui Gao and Haisheng Chen and Minghao Hu and Weiwei Liu and Yang Zhang and Dong Tu and Jianhua Hao}, doi = {10.1002/advs.202413409}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413409}, shortjournal = {Adv. Sci.}, title = {Force-triggered non-volatile multilevel mechano-optical memory system for logic computation and image recognition}, volume = {12}, year = {2025}, }
• (2025). A Hf(IV)-coordinated NIR-II fluorescence “Turn-on” nanoprobe for precise imaging-guided surgery in breast cancer. ADVS, 12(14), 2413385. (www)

  @article{ , abstract = {Breast-conserving surgery (BCS) has become the standard care for early-stage breast cancer. The accurate assessment of tumor margins is urgently required for BCS because positive resection margins often lead to local recurrence. To address this clinical dilemma, a Hf(IV)-coordinated NIR-II fluorescence “turn-on” nanoprobe based on the clinically approved NIR-II fluorescent dye indocyanine green (ICG) for intraoperative tumor visualization is developed. Notably, the fluorescence of ICG can be efficiently quenched by Hf(IV) and subsequently recovered in vivo, showing a remarkable fluorescence “quenching-recovery-amplification” capacity. This nanoprobe can effectively accumulate in tumor sites, accurately identifying submillimeter-sized primary and residual tumors with high sensitivity. In addition, subcutaneous, muscle-infiltrating, and orthotopic breast cancer models are built to repeatedly prove that this ultrasensitive nanoprobe is feasible for precise imaging-guided surgery in breast cancer. Overall, this study constructs an activatable fluorescent nanoprobe for real-time intraoperative tumor margin visualization, holding promise for complete surgical resection and reduction of local recurrence.}, archive = {J_ADVS}, author = {Yueyang He and Jinyan Lin and Jingwen Bai and Xiao Shen and Kangliang Lou and Yuanyuan Zhu and Zishan Qiao and Weiling Chen and Yang Li and Xiaolong Liu and Guojun Zhang}, doi = {10.1002/advs.202413385}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413385}, shortjournal = {Adv. Sci.}, title = {A Hf(IV)-coordinated NIR-II fluorescence “Turn-on” nanoprobe for precise imaging-guided surgery in breast cancer}, volume = {12}, year = {2025}, }
• (2025). Adrenal high-expressional CYP27A1 mediates bile acid increase and functional impairment in adult male offspring by prenatal dexamethasone exposure. ADVS, 12(14), 2413299. (www)

  @article{ , abstract = {Prenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects. This study found that PDE increased histone 3 lysine 27 acetylation (H3K27ac) levels in the promoter region of cholesterol 27 hydroxylase (CYP27A1) and its expression, as well as total bile acids (TBA) concentrations and enhanced endoplasmic reticulum stress (ERS) and inhibit steroid synthesis in adult male offspring rat adrenal glands. However, it is reversed in females. Tracing back to the prenatal stage and in combination with cellular experiments, it is further revealed that dexamethasone can regulate glucocorticoid receptor (GR)/SET binding protein 1 (SETBP1)/CYP27A1 signal pathway, consequently cause intracellular increase of bile acids. Finally, administration of nilvadipine (CYP27A1 inhibitor) to male offspring for 4 weeks after birth resulted in the reversal of PDE-induced adrenal morphological and functional damage. In conclusion, PDE induces fetal adrenal corticosteroid dysfunction in adult male offspring by upregulating CYP27A1 promoter region H3K27ac levels and expression in the adrenal gland through the GR/SETBP1 signaling pathway. This effect persists beyond birth, leading to bile acids local increase and subsequent enhancement of ERS, ultimately inducing cellular dysfunction in adult adrenal glands.}, archive = {J_ADVS}, author = {Jiangang Cao and Wen Hu and Yawen Chen and Aihemaitijiang Ailikaiti and Ziyi Zhang and Lingbo Rong and Hong Yu and Hui Wang}, doi = {10.1002/advs.202413299}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413299}, shortjournal = {Adv. Sci.}, title = {Adrenal high-expressional CYP27A1 mediates bile acid increase and functional impairment in adult male offspring by prenatal dexamethasone exposure}, volume = {12}, year = {2025}, }
• (2025). HDAC2-mediated METTL3 delactylation promotes DNA damage repair and chemotherapy resistance in triple-negative breast cancer. ADVS, 12(14), 2413121. (www)

  @article{ , abstract = {The current treatment of triple-negative breast cancer (TNBC) is still primarily based on platinum-based chemotherapy. However, TNBC cells frequently develop resistance to platinum and experience relapse after drug withdrawal. It is crucial to specifically target and eliminate cisplatin-tolerant cells after platinum administration. Here, it is reported that upregulated N 6 -methyladenosine (m 6 A) modification drives the development of resistance in TNBC cells during cisplatin treatment. Mechanistically, histone deacetylase 2 (HDAC2) mediates delactylation of methyltransferase-like 3 (METTL3), facilitating METTL3 interaction with Wilms’-tumor-1-associated protein and subsequently increasing m 6 A of transcript-associated DNA damage repair. This ultimately promotes cell survival under cisplatin. Furthermore, pharmacological inhibition of HDAC2 using Tucidinostat can enhance the sensitivity of TNBC cells to cisplatin therapy. This study not only elucidates the biological function of lactylated METTL3 in tumor cells but also highlights its negative regulatory effect on cisplatin resistance. Additionally, it underscores the nonclassical functional mechanism of Tucidinostat as a HDAC inhibitor for improving the efficacy of cisplatin against TNBC.}, archive = {J_ADVS}, author = {Xiaoniu He and Yuanpei Li and Jian Li and Yu Li and Sijie Chen and Xia Yan and Zhangrong Xie and Jiangfeng Du and Guoan Chen and Jianbo Song and Qi Mei}, doi = {10.1002/advs.202413121}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2413121}, shortjournal = {Adv. Sci.}, title = {HDAC2-mediated METTL3 delactylation promotes DNA damage repair and chemotherapy resistance in triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). Identification of a novel substrate for eEF2K and the AURKA-SOX8 as the related pathway in TNBC. ADVS, 12(14), 2412985. (www)

  @article{ , abstract = {Eukaryotic elongation factor 2 kinase (eEF2K) has been considered as a putative target for cancer therapy; however, the underlying mechanisms of eEF2K in triple-negative breast cancer (TNBC) progression remain to be fully elucidated. In this study, it is shown that eEF2K is highly expressed in TNBC and is associated with poor prognosis. In vitro, in vivo, and patient-derived organoid experiments demonstrate that knockdown of eEF2K significantly impedes progression of TNBC. Proteomic analysis and confirmation experiments reveal that eEF2K positively regulates the mRNA and protein expressions of sex-determining region Y-box 8 (SOX8). Mechanistically, eEF2K binds to and phosphorylates aurora kinase A (AURKA) at S391, a newly identified phosphorylation site critical for maintaining AURKA protein stability and kinase activity. Moreover, the compound C1, a molecular glue to degrade eEF2K, is optimized by designing and synthesizing its derivatives using reasonable structure-based optimization approach. The new compound C4 shows  better ability to degrade eEF2K and stronger anti-cancer activity than C1. These findings not only uncover the pivotal role of the eEF2K/AURKA/SOX8 axis in TNBC progression, but also provide a promising lead compound for developing novel drug for treatment of TNBC.}, archive = {J_ADVS}, author = {Xiaoya Wan and Rong Gong and Xiaobao Zhao and Yizhi Li and Tianjiao Shan and Changxin Zhong and Rongfeng Zhu and Zonglin Chen and Shilong Jiang and Linhao He and Shijun Cao and Sheng Tian and Jinming Yang and Na Ye and Wenjun Yi and Yan Cheng}, doi = {10.1002/advs.202412985}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412985}, shortjournal = {Adv. Sci.}, title = {Identification of a novel substrate for eEF2K and the AURKA-SOX8 as the related pathway in TNBC}, volume = {12}, year = {2025}, }
• (2025). Deciphering the oncogenic landscape of hepatocytes through integrated single-nucleus and bulk RNA-seq of hepatocellular carcinoma. ADVS, 12(14), 2412944. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality, while the hepatocyte mechanisms driving oncogenesis remains poorly understood. In this study, single-nucleus RNA sequencing of samples from 22 HCC patients revealed 10 distinct hepatocyte subtypes, including beneficial Hep0, predominantly malignant Hep2, and immunosuppressive Hep9. These subtypes were strongly associated with patient prognosis, confirmed in TCGA-LIHC and Fudan HCC cohorts through hepatocyte composition deconvolution. A quantile-based scoring method is developed to integrate data from 29 public HCC datasets, creating a Quantile Distribution Model (QDM) with excellent diagnostic accuracy (Area Under the Curve, AUC = 0.968-0.982). QDM was employed to screen potential biomarkers, revealing that PDE7B functions as a key gene whose suppression promotes HCC progression. Guided by the genes specific to Hep0/2/9 subtypes, HCC is categorized into metabolic, inflammatory, and matrix classes, which are distinguishable in gene mutation frequencies, survival times, enriched pathways, and immune infiltration. Meanwhile, the sensitive drugs of the three HCC classes are identified, namely ouabain, teniposide, and TG-101348. This study presents the largest single-cell hepatocyte dataset to date, offering transformative insights into hepatocarcinogenesis and a comprehensive framework for advancing HCC diagnostics, prognostics, and personalized treatment strategies.}, archive = {J_ADVS}, author = {Huanhou Su and Xuewen Zhou and Guanchuan Lin and Chaochao Luo and Wei Meng and Cui Lv and Yuting Chen and Zebin Wen and Xu Li and Yongzhang Wu and Changtai Xiao and Jian Yang and Jiameng Lu and Xingguang Luo and Yan Chen and Paul KH Tam and Chuanjiang Li and Haitao Sun and Xinghua Pan}, doi = {10.1002/advs.202412944}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412944}, shortjournal = {Adv. Sci.}, title = {Deciphering the oncogenic landscape of hepatocytes through integrated single-nucleus and bulk RNA-seq of hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Photoacoustic imaging in inflammatory orthopedic diseases: Progress toward precise diagnostics and predictive regulation. ADVS, 12(14), 2412745. (www)

  @article{ , abstract = {With the intensification of aging issues, inflammatory orthopedic diseases almost occur in the majority of elderly people, which is becoming increasingly severe. Photoacoustic imaging (PAI) is a non-invasive visualization technique for a clear diagnosis of the inflammation areas through detecting acoustic signals generated by the laser irradiation. The combination of “light input” and “acoustic output” provides unprecedented scalability as well as high penetration depth and resolution. This new imaging technology can also present more anatomical information and feedback status of inflammatory activity for the orthopedic diseases. Especially in inflammation imaging, this technology can effectively supplement current clinical imaging methods in diagnosis, staging, and monitoring of pathophysiological processes. With the rapid development of these new technologies, the goals of precise diagnosis, predictive regulation, and ultimately personalized treatment strategies are becoming increasingly realistic. Herein, this article introduces various orthopedic inflammations and related imaging technology applications. It covers the types of PA nanoprobes and their research progress in orthopedic inflammation, as well as the potential applications of PAI in various aspects. The review also discusses the recent researches and emerging translational applications of PAI in orthopedic inflammation, as well as the prospects and future development challenges of clinical transformation.}, archive = {J_ADVS}, author = {Mengyi Huang and Haoyu Yu and Rongyao Gao and Yuxin Liu and Xuhui Zhou and Limin Fu and Jing Zhou and Luoyuan Li}, doi = {10.1002/advs.202412745}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412745}, shortjournal = {Adv. Sci.}, title = {Photoacoustic imaging in inflammatory orthopedic diseases: Progress toward precise diagnostics and predictive regulation}, volume = {12}, year = {2025}, }
• (2025). High throughput screening of CMAS corrosion-resistant RETaO4 based on lamination method. ADVS, 12(14), 2412717. (www)

  @article{ , abstract = {Rare earth tantalates (RETaO 4 ), known for their exceptional thermomechanical properties, are promising candidates for next-generation thermal barrier coatings (TBCs). However, the role of rare earth (RE) species in the CMAS (calcium-magnesium-aluminosilicate) corrosion behavior and mechanisms of RETaO 4 remains unclear, hindering their design and application as TBCs. This study employs a high-throughput approach to systematically investigate the CMAS corrosion mechanisms of RETaO 4 (RE = Nd, Sm, Eu, Gd, Dy, Ho, Y, and Er) at 1300 °C. Precise analysis of the microstructure and composition reveal that the primary corrosion products are (Ca 2-x RE x )(Ta 2-y-z Mg y Al z )O 7 solid solutions, along with minor amounts of Ca 2 RE 8 (SiO 4 ) 6 O 2 apatite. These corrosion products are observed both in the recession layer and at grain boundaries. The CMAS infiltration depth of RETaO 4 increases with the RE ionic radius. First-principles calculations indicate that the formation enthalpy of corrosion products becomes more exothermic as the RE ionic radius increases, promoting the formation of corrosion products. Additionally, the wetting behavior of liquid CMAS on RETaO 4 at high temperatures supports that RETaO 4 with smaller RE ionic radius present better corrosion resistance. These findings provide insights into the influence of RE species on the CMAS corrosion behavior of RETaO 4 , offering guidelines for the rapid screening of CMAS-resistant TBC materials.}, archive = {J_ADVS}, author = {Zhilin Tian and Zhilin Chen and Shuping Wen and Wenxia Zhao and Liya Zheng and Bin Li}, doi = {10.1002/advs.202412717}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412717}, shortjournal = {Adv. Sci.}, title = {High throughput screening of CMAS corrosion-resistant RETaO4 based on lamination method}, volume = {12}, year = {2025}, }
• (2025). Interface-enhanced and self-guided growth of 2D interlayer heterostructure wafers with vertically aligned van der waals layers. ADVS, 12(14), 2412690. (www)

  @article{ , abstract = {2D heterostructures have garnered significant interest in the scientific community owing to their exceptional carrier transport properties and tunable band alignment. The fabrication of these heterostructures on a wafer scale is crucial for advancing industrial applications but remains particularly challenging for metals with low sulfidation activity, such as Hf. Herein, the one-pot method is developed for fabricating wafer-scale HfSe 2 /WSe 2 interlayer heterostructures with vertically aligned van der Waals layers via interface-enhanced selenization and self-guided growth. By depositing a W layer (high sulfidation activity) over a Hf layer, followed by a one-pot selenization process, the chemical combination between Hf and Se atoms is enhanced through interfacial Se diffusion and confined lattice reaction. Moreover, the WSe 2 layers grow perpendicular to the substrate and further guide the crystallization of the bottom HfSe 2 layers. The resulting heterostructures, characterized by covalent bonds, demonstrate significant charge transfer, enhanced piezoelectricity, notable rectification effects, and Si-compatible transistor integration. This interface-enhanced selenization and self-guided growth pathway may provide valuable insights into the fabrication of covalently connected interlayer heterostructures involving metals with low sulfidation activity, as well as the development of high-density integrated circuits.}, archive = {J_ADVS}, author = {Yi Hu and Xingli Wang and Xingguo Wang and Yue Gong and Zikun Tang and Guangchao Zhao and Weng Hou Yip and Jingyi Liu and Seoung Bum Lim and Mohamed Boutchich and Philippe Coquet and Shu Ping Lau and Beng Kang Tay}, doi = {10.1002/advs.202412690}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412690}, shortjournal = {Adv. Sci.}, title = {Interface-enhanced and self-guided growth of 2D interlayer heterostructure wafers with vertically aligned van der waals layers}, volume = {12}, year = {2025}, }
• (2025). Integrative multi-omics approaches reveal selectivity profiles and molecular mechanisms of FIIN-2, a covalent FGFR inhibitor. ADVS, 12(14), 2412578. (www)

  @article{ , abstract = {Fibroblast growth factor receptor (FGFR) inhibitors are emerged as an important class of targeted therapies in oncology, targeting key pathways associated with tumor growth, angiogenesis, and resistance to conventional treatments. FIIN-2, the first irreversible covalent pan-FGFR inhibitor, has shown promise in overcoming resistance due to gatekeeper mutations; however, its selectivity and molecular mechanisms in tumors remain poorly understood. In this study, an FIIN-2 chemical probe is designed and synthesized to identify both established and novel targets in hepatocellular carcinoma (HCC) via chemoproteomic profiling. An integrative multi-omics approach, including chemoproteomic, phosphoproteomic, transcriptomic, and proteomic analyses, is utilized to elucidate the full spectrum of target proteins, signaling pathways, and downstream effectors regulated by FIIN-2 in HCC. Notably, adenosine monophosphate-activated protein kinase α1 (AMPKα1) is identified as a novel target of FIIN-2, with Cys185 identified as its covalent binding site. These findings reveal that FIIN-2 can induce autophagy by directly binding to and activating AMPKα1, influencing its anti-tumor activity in HCC cells. Overall, this study greatly advances the understanding of FIIN-2′s on- and off-target effects, offering a comprehensive view of its molecular mechanisms in cancer cells. The integrative multi-omics approach provides a valuable framework for the development and optimization of covalent kinase inhibitors.}, archive = {J_ADVS}, author = {Ying Fu and Dandan Zhu and Xiaojuan Chen and Lingzhi Qu and Ming Guo and Shuhong Zhang and Guangyu Xu and Zhuchu Chen and Maoyu Li and Yongheng Chen}, doi = {10.1002/advs.202412578}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412578}, shortjournal = {Adv. Sci.}, title = {Integrative multi-omics approaches reveal selectivity profiles and molecular mechanisms of FIIN-2, a covalent FGFR inhibitor}, volume = {12}, year = {2025}, }
• (2025). Parkinson's disease modeling using directly converted 3D induced dopaminergic neuron organoids and assembloids. ADVS, 12(14), 2412548. (www)

  @article{ , abstract = {Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons and the accumulation of α-synuclein aggregates, yet current models inadequately mimic the complex human brain environment. Recent advances in brain organoid models offer a more physiologically relevant platform for studying PD, however, iPSC-derived brain organoids require long maturation times and may not accurately represent the aged brain's epigenetics and cellular contexts, limiting their applicability for modeling late-onset diseases like PD. In this study, a novel approach for generating 3D-induced dopaminergic (iDA) neuron organoids directly from human fibroblasts is presented. It is confirmed that these 3D iDA organoids more closely resemble the aged human brain and accurately replicate PD pathologies. Furthermore, this model is extended by incorporating astrocytes to create 3D iDA neuron-astrocyte assembloids, recognizing the critical role of glial cells in neurodegenerative processes. It is identified that PD assembloids incorporating control astrocytes with A53T mutant iDAs demonstrated the neuroprotective effects of healthy astrocytes. In contrast, A53T mutant astrocytes progressively contributed to neuronal degeneration and synucleinopathy in 3D-iDA assembloids. These findings suggest that directly converted 3D-iDA organoids and assembloids provide a robust and physiologically relevant model for studying PD pathogenesis and evaluating therapeutic interventions.}, archive = {J_ADVS}, author = {Hongwon Kim and Soi Kang and Byounggook Cho and Saemin An and Yunkyung Kim and Jongpil Kim}, doi = {10.1002/advs.202412548}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412548}, shortjournal = {Adv. Sci.}, title = {Parkinson's disease modeling using directly converted 3D induced dopaminergic neuron organoids and assembloids}, volume = {12}, year = {2025}, }
• (2025). Ge2Sb2Se4Te-based optical switch with ultra-high contrast ratio by multilayer Fabry–Perot cavity. ADVS, 12(14), 2412499. (www)

  @article{ , abstract = {Optical switches always desire a high contrast ratio in optical logic circuits and optical communication devices. Although phase change materials are widely applied to design optical switches for their rapid phase change, the high contrast ratio is still hardly achieved for the intrinsic loss of traditional PCMs. Here, the study demonstrates an optical switch with an ultra-high contrast ratio by introducing the Ge 2 Sb 2 Se 4 Te (GSST) into a multilayer film structure treated as a Fabry–Perot (FP) cavity. The reflectance of the multilayer system can be actively tuned by the phase change of GSST for the FP resonance to achieve an optical switch response. By designing the thicknesses of each layer in the multilayer film, the operating wavelength and the contrast ratio of the switch can be precisely controlled, and an ultra-high contrast ratio of 2410/735 (simulation/experiment) for the optical switch is constructed in the near-infrared band. The development of the GSST-based optical switch paves a new way to realize a high optical contrast ratio and offers a new strategy for high-performance optical devices.}, archive = {J_ADVS}, author = {Zhiyang Tang and Chensheng Li and Ruhao Pan and Bo Wang and Yunan Liu and Qianyu Wang and Junhao Tan and Yuan Xiang and Haifang Yang and Junjie Li}, doi = {10.1002/advs.202412499}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412499}, shortjournal = {Adv. Sci.}, title = {Ge2Sb2Se4Te-based optical switch with ultra-high contrast ratio by multilayer Fabry–Perot cavity}, volume = {12}, year = {2025}, }
• (2025). In vivo nanodiamond quantum sensing of free radicals in caenorhabditis elegans models. ADVS, 12(14), 2412300. (www)

  @article{ , abstract = {Free radicals are believed to play a secondary role in the cell death cascade associated with various diseases. In Huntington's disease (HD), the aggregation of polyglutamine (PolyQ) not only contributes to the disease but also elevates free radical levels. However, measuring free radicals is difficult due to their short lifespan and limited diffusion range. Here, a quantum sensing technique (T1 relaxometry) is used that involves fluorescent nanodiamonds (FND). Nitrogen vacancy (NV) centers within these nanodiamonds change their optical properties in response to magnetic noise, which allows detecting the unpaired electron from free radicals. This method is used to monitor the production of free radicals inside Caenorhabditis elegans models of Huntington's disease in vivo and in real-time. To investigate if radical generation occurs near polyglutamine expansions, a strain expressing Q40 yellow fluorescent protein (Q40::YFP, polyglutamine expansion overexpressed in the muscle) is used. By applying T1 relaxometry on FNDs in the body wall muscle, it is found that the production of free radicals significantly increase when PolyQ is expressed there (compared to the FNDs in intestine). The technique demonstrates the submicrometer localization of free radical information in living animals and direct measurement of their level, which may reveal the relation between oxidative stress and Huntington's disease.}, archive = {J_ADVS}, author = {Siyu Fan and Yue Zhang and Anna P. Ainslie and Renée Seinstra and Tao Zhang and Ellen Nollen and Romana Schirhagl}, doi = {10.1002/advs.202412300}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412300}, shortjournal = {Adv. Sci.}, title = {In vivo nanodiamond quantum sensing of free radicals in caenorhabditis elegans models}, volume = {12}, year = {2025}, }
• (2025). Quasi-continuous efficient regulation of single-molecule electronic distribution. ADVS, 12(14), 2412260. (www)

  @article{ , abstract = {The electronic distribution characteristics of molecules significantly influence the charge transport properties and the device performance of molecular electronic devices. These characteristics are closely related to subtle molecular structures, forming a formidable challenge for effective control. Here, a flexible crown ether moiety is integrated into the single-molecule junction, where its spatial structure can be regulated by an external electric field, enabling efficient tuning of the electronic characteristics. It is found that the transformation barriers between different structures and the conductance of single-molecule junctions can be adjusted by the external electric field. Both theoretical and experimental results consistently demonstrate that the interaction between the external electric field and the intrinsic molecular dipole can alter the molecular energy and stabilize a series of metastable molecular configurations, allowing for the quasi-continuous manipulation of the electronic characteristics. This study unveils efficient control of the single-molecule electronic characteristics by external electric fields, advancing a deeper understanding of molecular electronics and supramolecular chemistry.}, archive = {J_ADVS}, author = {Zhizhou Li and Weilin Hu and Shuyao Zhou and Changqing Xu and Mingyao Li and Jinying Wang and Suhang He and Liang Zhang and Chuancheng Jia and Xuefeng Guo}, doi = {10.1002/advs.202412260}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412260}, shortjournal = {Adv. Sci.}, title = {Quasi-continuous efficient regulation of single-molecule electronic distribution}, volume = {12}, year = {2025}, }
• (2025). Cell sizes matter for industrial bioproduction, a case of polyhydroxybutyrate. ADVS, 12(14), 2412256. (www)

  @article{ , abstract = {Most bacterial cells are 1–2 microns in size, limiting intracellular products like polyhydroxyalkanoates (PHA) accumulation. Cell size is regulated by key genes such as mreB and minCD , which encode cellular skeleton protein and control cell fission ring location, respectively. Their expression changes significantly affect microbial growth. This study successfully redesigns the ClpXP protein degradation system by deleting the sspB gene and using mutated SsrA tags with different degradation rates to control MreB degradation. Dynamic degradation of MreB allows non-model bacterium Halomonas bluephagenesis to grow normally and increase cell size simultaneously. Combined with overexpression of minCD , H. bluephagenesis with progressive MreB degradation increases the cell size further, albeit with a reduced growth rate. H. bluephagenesis CYL0307, with the PHB granule-associated protein PhaP1 deleted and phaAB Re overexpressed in the MreB-degraded strain, increases cell volume more than nine times compared to the original strain. CYL0307 produces 149 g L −1 cell dry weight containing 82% PHB after 44 h in a 5000 L bioreactor, with cells containing single large PHB granules, simplifying recovery and purification. These results provide a post-translational gene regulation method in H. bluephagenesis and a strategy for enhancing PHB production via morphological engineering.}, archive = {J_ADVS}, author = {Yi-Ling Chen and Xu Liu and Li-Zhan Zhang and Ji-Shuai Yang and Wei-Ke Guo and Shuang Zheng and Jia-Le Wang and Fu-Qing Wu and Xu Yan and Qiong Wu and Guo-Qiang Chen}, doi = {10.1002/advs.202412256}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412256}, shortjournal = {Adv. Sci.}, title = {Cell sizes matter for industrial bioproduction, a case of polyhydroxybutyrate}, volume = {12}, year = {2025}, }
• (2025). Laser-induced graphene from commercial inks and dyes. ADVS, 12(14), 2412167. (www)

  @article{ , abstract = {Laser-induced graphene (LIG) has been so far obtained from polymer precursors and proposed for numerous applications, including various types of sensors and energy storage solutions. This study examines a radically different class of new precursors for LIG, distinct from polymers: inks and dyes. The identification of specific organic dyes present in commercial markers demonstrates that the aromatic structure, in conjunction with high thermal stability (residual weight > 20% at 800°C), are key factors for laser-induced pyrolysis. Eosin Y is identified as an excellent LIG precursor, comparable with well-known polyimide. The unique properties of dyes allow for dispersion in various media, such as acrylic binder. A dye concentration of 0.75 mol L −1 in acrylic binder results in a conductivity of 34 ± 20 S cm −1 for LIG. The composition and microstructure of LIG from dyes are thoroughly characterized, revealing peculiar features. A versatile “Paint & Scribe” methodology is introduced, enabling to integrate LIG tracks onto any wettable surface, and in particular onto printed and flexible electronics. A process for obtaining freestanding and transferrable LIG is demonstrated by dissolving acrylic paint in acetone and floating LIG in water. This advancement offers novel avenues for diverse applications that necessitate a transfer process of LIG.}, archive = {J_ADVS}, author = {Alexander Dallinger and Rachel Camerini and Paola Parlanti and Mauro Gemmi and Sreenadh Thaikkattu Sankaran and Marina Galliani and Birgit Kunert and Rodorico Giorgi and Francesco Greco}, doi = {10.1002/advs.202412167}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412167}, shortjournal = {Adv. Sci.}, title = {Laser-induced graphene from commercial inks and dyes}, volume = {12}, year = {2025}, }
• (2025). Perillaldehyde improves parkinson-like deficits by targeting G3BP mediated stress granule assembly in preclinical models. ADVS, 12(14), 2412152. (www)

  @article{ , abstract = {Stress granules (SGs) fulfill a pivotal role in host defense mechanisms, by sequestering both mRNA and protein via the process of liquid–liquid phase separation (LLPS). In this study, we showed that perillaldehyde (PAE), a natural occurring compound, bound directly to the core protein of SGs, Ras GTPase-activating protein-binding protein 1/2 (G3BP1/2), thereby inducing the assembly of SGs through the LLPS of G3BP/RNA complexes in vitro. Moreover, in Parkinson's disease (PD) models using Caenorhabditis elegans ( C. elegans ) and mice, PAE administration prompted SG formation, enhanced eIF2α phosphorylation, shielded dopaminergic neurons from toxic insults, mitigated α-synuclein (α-syn) aggregation, and improved PD-like motor disorders. In addition, these findings revealed that the interaction between G3BP1 and histone deacetylase 6 (HDAC6) inhibited the functions of cytoplasmic HDAC6 and reduced α-syn aggregation in cells and worms. Notably, the inhibition of SG assembly via gtbp-1 and tiar-1 RNAi effectively counteracted the beneficial effects of PAE in C. elegans . Collectively, these results imply that PAE may exert neuroprotective effects by targeting G3BP-mediated SG formation, thereby safeguarding dopaminergic neurons from toxic damage.}, archive = {J_ADVS}, author = {Minglv Fang and Lingling Luo and Youjia Chen and Ying Liu and Yingxuan Yan and Fei Wang and Yan Zou and Huanhu Zhu and Xiaojun Wu and Zhigang Jin and Cheng Huang and Yu Zhang and Shengjie Fan}, doi = {10.1002/advs.202412152}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412152}, shortjournal = {Adv. Sci.}, title = {Perillaldehyde improves parkinson-like deficits by targeting G3BP mediated stress granule assembly in preclinical models}, volume = {12}, year = {2025}, }
• (2025). Selenium electrophilic center responsive to biological electron donors for efficient chemotherapy. ADVS, 12(14), 2412062. (www)

  @article{ , abstract = {Designing drugs to intelligently respond to different ratio of biological electron donors/receptors in cancer cells and normal cells is a promising strategy to achieve highly effective and less toxic chemotherapy. Herein by employing metal center to active the selenium-containing electrophilic center drug Ru(phtpy-NO 2 )(phenSe)Cl ( RuSe ) with strongly polarization characteristics are synthesized which can efficiently shuttle electrons from biological electron donors to convert to oxidative stress. The rate of electron transfer at the selenium electrophilic center is 1.81 times higher in cancer cell environments compared to normal cell environments. This results in the selenium electrophilic center being 14.98 times more lethal to cancer cells than to normal cells. Experimental results demonstrate that the transport of electrons process is carried out via selenium radicals intermediate and the rate of electron transport is positively correlated with the polarization properties of the electrophilic center atoms. The selenium electrophilic center transports bioactive electrons to generate a large number of superoxide anions leading to DNA damage and a decrease in mitochondrial membrane potential which further activates the p53 signaling pathway and amplifies the cancer cell-killing effect after transporting bioactive electrons. This work provides a new avenue for the design of efficient and less toxic chemotherapeutic agents.}, archive = {J_ADVS}, author = {Xiaoyu Qin and Junxian Guo and Hui Li and Hanlong He and Fei Cai and Xinyan Chen and Mingkai Chen and Tianfeng Chen and Li Ma}, doi = {10.1002/advs.202412062}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412062}, shortjournal = {Adv. Sci.}, title = {Selenium electrophilic center responsive to biological electron donors for efficient chemotherapy}, volume = {12}, year = {2025}, }
• (2025). Using spinodal decomposition to investigate diffusion enhancement and vacancy population. ADVS, 12(14), 2412060. (www)

  @article{ , abstract = {Material sustainability requires energy-efficient and rapid strengthening processes. In alloys, strengthening through diffusion-driven precipitation is limited by the low vacancy concentration, with fewer than one vacancy per 100 billion lattice sites at room temperature in metals such as aluminum and iron under thermodynamic equilibrium. Artificially increasing vacancy concentrations by 1 to 7 orders of magnitude above equilibrium levels through quenching, irradiation, or deformation can significantly accelerate material strengthening. However, measuring vacancy concentrations below 10 −7 in alloys and achieving spatial mapping remain challenging. Here, a vacancy-mediated gradient microstructure near grain boundaries is reported and analyzed to investigate diffusion enhancement and the local vacancy population in an Al-Zn system. This method uses cryogenic processes to preserve excess vacancies and halt microstructure evolution, enabling intermittent measurement of compositional fluctuations during ultrafast spinodal decomposition. It allows for the assessment of diffusion enhancement and determination of vacancy supersaturation in sub-micrometer regions. Liquid nitrogen–quenched Al–12.5 at.% Zn alloy shows a vacancy concentration of ≈10 −7 at room temperature, dropping to 10 −9 after 3 h, with significant spatial variation near grain boundaries. This work addresses gaps in understanding the evolution and distribution of vacancies across various measurement scales, advancing the control of vacancies to enhance the strengthening of engineering alloys.}, archive = {J_ADVS}, author = {Xinren Chen and Frédéric De Geuser and Alisson Kwiatkowski da Silva and Chuanlai Liu and Eric Woods and Dirk Ponge and Baptiste Gault and Dierk Raabe}, doi = {10.1002/advs.202412060}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2412060}, shortjournal = {Adv. Sci.}, title = {Using spinodal decomposition to investigate diffusion enhancement and vacancy population}, volume = {12}, year = {2025}, }
• (2025). Multidimensional engineering of escherichia coli for efficient adipic acid synthesis from cyclohexane. ADVS, 12(14), 2411938. (www)

  @article{ , abstract = {Adipic acid (AA), a key aliphatic dicarboxylic acid, is conventionally manufactured through energy-intensive, multi-step chemical processes with significant environmental impacts. In contrast, biological production methods offer more sustainable alternatives but are often limited by low productivity. To overcome these challenges, this study reports the engineering of a single Escherichia coli for efficient biosynthesis of AA starting from cyclohexanol (CHOL), KA oil (mixture of CHOL and cyclohexanone (CHONE)), or cyclohexane (CH). To start with, a comprehensive screening of rate-limiting enzymes is conducted, particularly focusing on cytochrome P450 monooxygenase, followed by the optimization of protein expression using strategies such as protein fusion, promoter replacement, and genome editing. Consequently, an engineered E. coli capable of efficiently converting either KA oil or CH into AA is obtained, achieving remarkable product titers of 110 and 22.6 g L −1 , respectively. This represents the highest productivity record for the biological production of AA to date. Finally, this developed biocatalytic system is successfully employed to convert different cycloalkanes and cycloalkanols with varied carbon chain lengths into their corresponding dicarboxylic acids, highlighting its great potential as well as broad applicability for industrial applications.}, archive = {J_ADVS}, author = {Fei Wang and Huiqi Sun and Di Deng and Yuanqing Wu and Jing Zhao and Qian Li and Aitao Li}, doi = {10.1002/advs.202411938}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2411938}, shortjournal = {Adv. Sci.}, title = {Multidimensional engineering of escherichia coli for efficient adipic acid synthesis from cyclohexane}, volume = {12}, year = {2025}, }
• (2025). Rational design of natural xanthones against gram-negative bacteria. ADVS, 12(14), 2411923. (www)

  @article{ , abstract = {Most antibiotics are ineffective against Gram-negative bacteria owing to the existence of the outer membrane (OM) barrier. The rational design of compounds to expand their antibacterial spectra of antibiotics solely targeting Gram-positive pathogens remains challenging. Here, the design of skeletons from natural products to penetrate the OM are deciphered. Structure-activity relationship analysis shows the optimization of the model of natural xanthones α-mangostin endows the broad-spectrum antibacterial activity. Mechanistic studies demonstrate the lead compound A20 penetrates the OM in a self-promoted pathway through electronic and hydrophobic interactions with lipopolysaccharides and phospholipids in OM. A20 displays rapid bactericidal activity by targeting the cofactor heme in the respiratory complex. The therapeutic efficacy of A20 is demonstrated in two animal models infected with multidrug-resistant Gram-negative bacterial pathogens. The findings elucidate the structural property and self-promoted transportation of a class of antibacterial compounds, to facilitate the design and discovery of antibacterial agents against increasingly prevalent Gram-negative pathogens associated with infections.}, archive = {J_ADVS}, author = {Xiaojia Liu and Meirong Song and Ying Liu and Shuyu Yang and Shang Chen and Jijun Kang and Jianzhong Shen and Kui Zhu}, doi = {10.1002/advs.202411923}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2411923}, shortjournal = {Adv. Sci.}, title = {Rational design of natural xanthones against gram-negative bacteria}, volume = {12}, year = {2025}, }
• (2025). EIF4A3-mediated biogenesis of CircFADS1 promotes the progression of hepatocellular carcinoma via wnt/β-catenin pathway. ADVS, 12(14), 2411869. (www)

  @article{ , abstract = {Mounting research indicates that circRNAs are pivotal elements in tumorigenesis and progression. Understanding the mechanisms by which circRNAs function in tumors is crucial for identifying undiscovered diagnostic and treatment targets. This research centers on unraveling the mechanisms by which the novel circRNA, circFADS1, influences hepatocellular carcinoma (HCC) progression. CircFADS1 shows elevated expression in HCC and is linked to unfavorable prognosis. Functionally, circFADS1 overexpression accelerates HCC progression through inducing HCC proliferation and inhibited apoptosis. Mechanistically, RNA-seq analysis demonstrates its connection to the Wnt/β-catenin pathway. Moreover, circFADS1 interacts with GSK3β and promotes its ubiquitination and degradation by recruiting the ubiquitin ligase RNF114 while EIF4A3 facilitates the biogenesis of circFADS1. Additionally, circFADS1 is closely linked to lenvatinib resistance. Overall, this study reveals that circFADS1 regulates GSK3β function, influencing the progression of hepatocellular carcinoma. The EIF4A3/circFADS1/GSK3β/β-catenin axis is discovered to hold promise as a novel therapeutic target for hepatocellular carcinoma, while circFADS1 is also a significant factor in lenvatinib resistance.}, archive = {J_ADVS}, author = {Lei Tang and Yang Ji and Chuangye Ni and Zhenggang Xu and Yanjun Shen and Hao Lu and Chuanyong Zhang and Shikun Yang}, doi = {10.1002/advs.202411869}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2411869}, shortjournal = {Adv. Sci.}, title = {EIF4A3-mediated biogenesis of CircFADS1 promotes the progression of hepatocellular carcinoma via wnt/β-catenin pathway}, volume = {12}, year = {2025}, }
• (2025). Dipeptidic phosphonates: Potent inhibitors of pseudomonas aeruginosa elastase b showing efficacy in a murine keratitis model. ADVS, 12(14), 2411807. (www)

  @article{ , abstract = {The ubiquitous opportunistic pathogen Pseudomonas aeruginosa is responsible for severe infections and notoriously known for acquiring antimicrobial resistance. Inhibiting the bacterium's extracellular elastase, LasB – a zinc-dependent protease – presents a promising strategy to mitigate its virulence. Within this medicinal chemistry–driven hit-to-lead optimization campaign, a new series of highly potent dipeptidic phosphonates is designed and synthesized following a structure–based drug-discovery approach. In vitro and in vivo evaluation reveal beneficial pharmacokinetic profiles, excellent selectivity over human off-targets and good tolerability in murine toxicity studies. Ultimately, the scaffold presented herein demonstrates promising in vivo efficacy in a murine Pseudomonas aeruginosa keratitis model in combination with the antibiotic meropenem.}, archive = {J_ADVS}, author = {Alexander F. Kiefer and Christian Schütz and Colya N. Englisch and Dominik Kolling and Samira Speicher and Andreas M. Kany and Roya Shafiei and Noran A. Wadood and Ahmad Aljohmani and Niklas Wirschem and Ravindra P. Jumde and Andreas Klein and Asfandyar Sikandar and Yu-Mi Park and Gabriela Krasteva-Christ and Daniela Yildiz and Ahmed S. Abdelsamie and Katharina Rox and Jesko Köhnke and Rolf Müller and Markus Bischoff and Jörg Haupenthal and Anna K. H. Hirsch}, doi = {10.1002/advs.202411807}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2411807}, shortjournal = {Adv. Sci.}, title = {Dipeptidic phosphonates: Potent inhibitors of pseudomonas aeruginosa elastase b showing efficacy in a murine keratitis model}, volume = {12}, year = {2025}, }
• (2025). Multiomics and systematic analyses reveal the roles of hemoglobin and the HIF-1 pathway in polycystic ovary syndrome. ADVS, 12(14), 2411679. (www)

  @article{ , abstract = {Polycystic ovary syndrome (PCOS) affects reproductive and cardiometabolic health, yet its pathogenesis remains unclear. Emerging evidence links hemoglobin levels to metabolic disorders, suggesting a potential role in PCOS development. Here, we integrated a large-scale cohort study, Mendelian randomization (A genetic tool to infer causal relationships), bioinformatics analyses, and in vitro experiments to investigate the relationship between hemoglobin levels and PCOS. In a cohort of 20 602 women, each 10 g L −1 elevation in hemoglobin levels is associated with 22% higher odds of PCOS (adjusted odds ratio: 1.22, 95% confidence interval: 1.15–1.29, P < 0.001) and PCOS manifestations, particularly hyperandrogenism. Mendelian randomization analysis confirms that higher hemoglobin levels are associated with increased PCOS risk and elevated testosterone levels. The hypoxia-inducible factor 1 (HIF-1) pathway is enriched, identifying three testosterone-associated genes (nuclear factor kappa B (NFKB1) , insulin receptor (INSR) , protein kinase C alpha. Colocalization and druggability analysis supports shared genetic regions and confirmed these genes as druggable targets. Upregulation of NFKB1 and INSR are confirmed in both blood and ovarian granulosa cells of PCOS patients. The findings demonstrate that higher-end normal hemoglobin levels are associated with increased PCOS risk, potentially through a mechanism of elevating testosterone levels involving the HIF-1 pathway.}, archive = {J_ADVS}, author = {Guiquan Wang and Weian Mao and Yurong Zhang and Haiyan Yang and Ming Zhu and Yan Li and Wei Chen and Yi Chen and Chen Lou and Ping Li and Hsun-Ming Chang and Shuai Yuan and Yue Zhao and Liangshan Mu}, doi = {10.1002/advs.202411679}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2411679}, shortjournal = {Adv. Sci.}, title = {Multiomics and systematic analyses reveal the roles of hemoglobin and the HIF-1 pathway in polycystic ovary syndrome}, volume = {12}, year = {2025}, }
• (2025). Sequence context-agnostic TadA-derived cytosine base editors for genome-wide editing in zebrafish. ADVS, 12(14), 2411478. (www)

  @article{ , abstract = {Single-nucleotide variants (SNVs) represent a significant form of genetic variation linked to various diseases. CRISPR-mediated base editing has emerged as a powerful method for modeling diseases caused by SNVs, particularly in zebrafish, which serve as an excellent platform for investigating disease mechanisms and conducting drug screenings. However, existing cytosine base editors (CBEs) for zebrafish often have broad editing windows and strong sequence preferences, limiting their effectiveness. In this study, zebrafish (z) TadA-derived cytosine base editors, termed zTadA-CBEs, are developed by introducing key mutations into the TadA8e enzyme. These novel editors demonstrate improved efficiency and precision in cytosine base editing. Specifically, zTadA-BE4max and zTadA-BEmv offer complementary editing windows, while zTadA-SpRY-BE4max allows for PAM-flexible editing. Using zTadA-CBEs, a precise disease model for Axenfeld-Rieger syndrome is established, and created two new models for Hermansky-Pudlak syndrome. Additionally, a novel albinism model carrying two pathogenic SNVs in the F0 generation is developed. By employing specifically designed sgRNA, the fms ts± missense mutation is corrected back to the wild-type nucleotide (C > T), successfully restoring macrophage levels to normal. These findings underscore the potential of zTadA-CBEs to enhance genome editing techniques and their applications in developing therapies for SNV-related disorders.}, archive = {J_ADVS}, author = {Shaohui Zheng and Yang Liu and Xinxin Xia and Jiawang Xiao and Hui Ma and Xuanyao Yuan and Yan Zhang and Zixi Chen and Guangcong Peng and Wenyuan Li and Ji-Feng Fei and Yanmei Liu}, doi = {10.1002/advs.202411478}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2411478}, shortjournal = {Adv. Sci.}, title = {Sequence context-agnostic TadA-derived cytosine base editors for genome-wide editing in zebrafish}, volume = {12}, year = {2025}, }
• (2025). Applications of artificial intelligence in drug repurposing. ADVS, 12(14), 2411325. (www)

  @article{ , abstract = {Drug repurposing identifies new therapeutic uses for the existing drugs originally developed for different indications, aiming at capitalizing on the established safety and efficacy profiles of known drugs. Thus, it is beneficial to bypass of early stages of drug development, and to reduction of the time and cost associated with bringing new therapies to market. Traditional experimental methods are often time-consuming and expensive, making artificial intelligence (AI) a promising alternative due to its lower cost, computational advantages, and ability to uncover hidden patterns. This review focuses on the availability of AI algorithms in drug development, and their positive and specific roles in revealing repurposing of the existing drugs, especially being integrated with virtual screening. It is shown that the existing AI algorithms excel at analyzing large-scale datasets, identifying the complicated patterns of drug responses from these datasets, and making predictions for potential drug repurposing. Building on these insights, challenges remain in developing efficient AI algorithms and future research, including integrating drug-related data across databases for better repurposing, enhancing AI computational efficiency, and advancing personalized medicine.}, archive = {J_ADVS}, author = {Zhaoman Wan and Xinran Sun and Yi Li and Tianyao Chu and Xueyu Hao and Yang Cao and Peng Zhang}, doi = {10.1002/advs.202411325}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2411325}, shortjournal = {Adv. Sci.}, title = {Applications of artificial intelligence in drug repurposing}, volume = {12}, year = {2025}, }
• (2025). Fibroblast activation protein acts as a biomarker for monitoring ECM remodeling during aortic aneurysm via 68Ga-FAPI-04 PET imaging. ADVS, 12(14), 2411152. (www)

  @article{ , abstract = {Traditional imaging modalities used to monitor the diameter of aortic aneurysms (AAs) often fail to follow pathological progression. Fibroblast activation protein (FAP), a key regulator of extracellular matrix (ECM) remodeling, plays a pivotal role in aortic disease. However, its expression in the aortic wall during aneurysm progression and its potential correlation with disease severity remains unexplored. Here, utilizing histology the levels of FAP are higher in the aortic wall of patients with AA compared to healthy controls. In three distinct animal models of AA, a progressive increase in FAP expression, coincides with the advancement of ECM remodeling. Notably, the levels of 68 Ga-FAPI-04 uptake in a rabbit model of abdominal AA (AAA) is positively correlated with aortic dilation ( r = 0.84, p < 0.01), and the histological examination further confirmed that regions of high 68 Ga-FAPI-04 uptake exhibited both increased FAP expression and more severe pathological changes. The 68 Ga-FAPI-04 imaging in AA patients showed that the radiotracer specifically accumulated in the aortic walls of persistently dilated AA. These findings suggest that 68 Ga-FAPI-04 positron emission tomographic (PET) imaging, by visualizing FAP localization, allows for a non-invasive approach to potentially monitor ECM remodeling during the AA progression.}, archive = {J_ADVS}, author = {Chengkai Hu and Hui Tan and Yuchong Zhang and Genmao Cao and Chenye Wu and Peng Lin and Shouji Qiu and Fandi Mo and Enci Wang and Shiyi Li and Tong Yuan and Zheyun Li and Weiguo Fu and Dengfeng Cheng and Hao Lai and Xiaoyuan Chen and Lixin Wang}, doi = {10.1002/advs.202411152}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2411152}, shortjournal = {Adv. Sci.}, title = {Fibroblast activation protein acts as a biomarker for monitoring ECM remodeling during aortic aneurysm via 68Ga-FAPI-04 PET imaging}, volume = {12}, year = {2025}, }
• (2025). Molybdate-modified NiOOH for efficient methanol-assisted seawater electrolysis. ADVS, 12(14), 2410911. (www)

  @article{ , abstract = {Seawater electrolysis holds great promise for sustainable, green hydrogen production but faces challenges of high overpotentials and competing chlorine evolution reaction (CER). Replacing the oxygen evolution reaction with the methanol oxidation reaction (MOR) presents a compelling alternative due to its lower anodic potential which mitigates the risk of CER. While NiOOH is known for its MOR activity, its performance is limited by sluggish non-electrochemical kinetics and Cl-induced degradation. Herein, a MoO 4 2− -modified NiOOH electrocatalyst is reported that significantly enhances MOR-assisted seawater splitting efficiency. In situ leached MoO 4 2− from the heterojunction optimizes methanol adsorption and facilitates proton migration, thereby accelerating the non-electrochemical steps in MOR. Additionally, the adsorbed MoO 4 2− effectively repels Cl − , protecting the electrodes from Cl − -induced corrosion. The MOR-assisted electrolyzer using NiMo||Ni(OH) 2 /NiMoO₄ requires only 1.312 V to achieve 10 mA cm −2 , substantially lower than conventional alkaline seawater electrolysis (1.576 V). Furthermore, it demonstrates remarkable stability, sustaining high current densities (up to 1.0 A cm −2 ) for over 130 h. This work presents a promising strategy for designing high-performance electrocatalysts for efficient and sustainable green hydrogen production from seawater.}, archive = {J_ADVS}, author = {Zhen Li and Youbin Zheng and Wenhan Zu and Liang Dong and Lawrence Yoon Suk Lee}, doi = {10.1002/advs.202410911}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2410911}, shortjournal = {Adv. Sci.}, title = {Molybdate-modified NiOOH for efficient methanol-assisted seawater electrolysis}, volume = {12}, year = {2025}, }
• (2025). Condensate halos in condensation frosting. ADVS, 12(14), 2410657. (www)

  @article{ , abstract = {The freezing of water drops on cold solid surfaces is ubiquitous in nature, and generally causes serious technological, engineering, and economic issues in industrial applications. Despite longstanding research efforts, existing knowledge on dropwise freezing is still limited, as this phase-change phenomenon is always accompanied by complex heat and mass transfer processes. Herein, drop-freezing phenomena in condensation frosting are investigated under standard laboratory conditions of humidity and pressure, highlighting their distinctions from those under some limiting conditions. Condensate halos consisting of massive tiny droplets are observed to form, grow, and eventually fade in a well-defined region around freezing supercooled drops on sufficiently hydrophobic surfaces with low thermal conductivities. The detailed halo evolution is very different from that reported previously in ultradry and low ambient pressure environments, and it shows no identifiable effect on the long-term frost propagation. By combining optical and thermal imaging techniques, this study scrutinizes the halo pattern evolution involving multiphase transitions on timescales from milliseconds to seconds, assesses the halo characteristics at each stage, and elucidates the underlying mechanisms. The work expands the fundamental understanding of complex dropwise freezing dynamics, and relevant findings can provide important guidance for developing anti-icing/frosting strategies.}, archive = {J_ADVS}, author = {Songyuan Zhen and Haoyan Feng and Shiji Lin and Yakang Jin and Zhigang Li and Xu Deng and Elmar Bonaccurso and Longquan Chen}, doi = {10.1002/advs.202410657}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2410657}, shortjournal = {Adv. Sci.}, title = {Condensate halos in condensation frosting}, volume = {12}, year = {2025}, }
• (2025). CircDNA2-educated YTHDF2 phase separation promotes PM2.5-induced malignant transformation through the blunting of GADD45A expression. ADVS, 12(14), 2410532. (www)

  @article{ , abstract = {Substantial epidemiological evidence suggests a significant correlation between particulate matter 2.5 (PM 2.5 ) and lung cancer. However, the mechanism underlying this association needs to be further elucidated. Circular RNAs (circRNAs) have emerged as an important topic in the field of epigenetics and are involved in various cancers. This study aimed to explore the molecular basis of PM 2.5 -induced lung cancer from an epigenetic perspective and identify potential biomarkers. Initially, the construction of a chronic PM 2.5 exposure model confirmed that PM 2.5 exposure promoted the malignant transformation of human bronchial epithelial (HBE) cells. Mechanistically, abnormally upregulated circDNA2 inhibited the tumor suppressor gene growth arrest and DNA damage 45 alpha (GADD45A) mRNA in an N6-methyladenosine (m 6 A)-dependent manner, mediated by YTH N6-Methyladenosine RNA Binding Protein F2 (YTHDF2) after PM 2.5 exposure. Further analyses revealed that circDNA2 can specifically bind to the YTHDF2 LC domain to promote YTHDF2 protein liquid–liquid phase separation (LLPS), providing sufficient evidence linking LLPS and particulate pollutant-induced tumorigenesis. In conclusion, this study provides new insights into the role of circDNA2 in PM 2.5 -induced lung cancer and confirms its clinical value as a potential prognostic biomarker for lung cancer.}, archive = {J_ADVS}, author = {Jie Xu and Zhi Ling and Lijia Yin and Duo Xu and Shenshen Wu and Rui Chen}, doi = {10.1002/advs.202410532}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2410532}, shortjournal = {Adv. Sci.}, title = {CircDNA2-educated YTHDF2 phase separation promotes PM2.5-induced malignant transformation through the blunting of GADD45A expression}, volume = {12}, year = {2025}, }
• (2025). Advancing precision medicine: Recent innovations in gene editing technologies. ADVS, 12(14), 2410237. (www)

  @article{ , abstract = {The advent of gene editing has significantly advanced the field of medicine, opening new frontiers in the treatment of genetic disorders, cancer, and infectious diseases. Gene editing technology remains a dynamic and promising area of research and development. Recent advancements in protein and RNA engineering within this field have addressed critical issues such as imprecise edits, poor editing efficiency, and off-target effects. Advancements in delivery methods have allowed the achievement of therapeutic or even selection-free gene editing efficiency with reduced toxicity in primary cells, thereby enhancing the safety and efficacy of gene manipulation. This progress paves the way for transformative changes in molecular biology, medicine, and other fields. This review provides a comprehensive overview of the advancements in gene editing techniques, focusing on prime editor proteins and their engineered variants. It also explores alternative systems that expand the toolkit for precise genomic modifications and highlights the potential of these innovations in treating hematological disorders, while also discussing the limitations and challenges that remain.}, archive = {J_ADVS}, author = {Abhijith Koodamvetty and Saravanabhavan Thangavel}, doi = {10.1002/advs.202410237}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2410237}, shortjournal = {Adv. Sci.}, title = {Advancing precision medicine: Recent innovations in gene editing technologies}, volume = {12}, year = {2025}, }
• (2025). Brain-wide neuroregenerative gene therapy improves cognition in a mouse model of alzheimer's disease. ADVS, 12(14), 2410080. (www)

  @article{ , abstract = {Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the neocortex and hippocampus. Current therapeutic interventions focus on the early stage of AD but lack effective treatment for the late stage of AD, largely due to the inability to replenish the lost neurons and repair the broken neural circuits. In this study, by using engineered adeno-associated virus vectors that efficiently cross the blood–brain-barrier in the mouse brain, a brain-wide neuroregenerative gene therapy is developed to directly convert endogenous astrocytes into functional neurons in a mouse model of AD. It is found that ≈500 000 new neurons are regenerated and widely distributed in the cerebral cortex and hippocampus. Importantly, it is demonstrated that the converted neurons can integrate into pre-existing neural networks and improve various cognitive performances in AD mice. Chemogenetic inhibition of the converted neurons abolishes memory enhancement in AD mice, suggesting a pivotal role for the newly converted neurons in cognitive restoration. Together, brain-wide neuroregenerative gene therapy may provide a viable strategy for the treatment of AD and other brain disorders associated with massive neuronal loss.}, archive = {J_ADVS}, author = {Zheng Wu and Liang Xu and Yu Xie and Abhijeet Sambangi and Shreya Swaminathan and Zifei Pei and Wenyu Ji and Zeru Li and Yaowei Guo and Zhifei Li and Gong Chen}, doi = {10.1002/advs.202410080}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2410080}, shortjournal = {Adv. Sci.}, title = {Brain-wide neuroregenerative gene therapy improves cognition in a mouse model of alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Improved efficacy of triple-negative breast cancer immunotherapy via hydrogel-based co-delivery of CAR-T cells and mitophagy agonist. ADVS, 12(14), 2409835. (www)

  @article{ , abstract = {Leaky and structurally abnormal blood vessels and increased pressure in the tumor interstitium reduce the infiltration of CAR-T cells in solid tumors, including triple-negative breast cancer (TNBC). Furthermore, high burden of tumor cells may cause reduction of infiltrating CAR-T cells and their functional exhaustion. In this study, various effector-to-target (E:T) ratio experiments are established to model the treatment using CAR-T cells in leukemia (high E:T ratio) and solid tumor (low E:T ratio). It is found that the antitumor immune response is decreased in solid tumors with low E:T ratio. Furthermore, single cell sequencing is performed to investigate the functional exhaustion at a low ratio. It is revealed that the inhibition of mitophagy-mediated mitochondrial dysfunction diminished the antitumor efficacy of CAR-T-cell therapy. The mitophagy agonist BC1618 is screened via AI-deep learning and cytokine detection, in vivo and in vitro studies revealed that BC1618 significantly strengthened the antitumor response of CAR-T cells via improving mitophagy. Here, injection hydrogels are engineered for the controlled co-delivery of CAR-T cells and BC1618 that improves the treatment of TNBC. Local delivery of hydrogels creates an inflammatory and mitophagy-enhanced microenvironment at the tumor site, which stimulates the CAR-T cells proliferation, provides antitumor ability persistently, and improves the effect of treatment.}, archive = {J_ADVS}, author = {Guodong Li and Ruoxin Du and Donghui Wang and Xiangmei Zhang and Lizhuo Wang and Shuangpeng Pu and Xiaoju Li and Shuning Wang and Juliang Zhang and Beichen Liu and Yuan Gao and Huadong Zhao}, doi = {10.1002/advs.202409835}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2409835}, shortjournal = {Adv. Sci.}, title = {Improved efficacy of triple-negative breast cancer immunotherapy via hydrogel-based co-delivery of CAR-T cells and mitophagy agonist}, volume = {12}, year = {2025}, }
• (2025). Peptide multifunctionalization via modular construction of trans-AB2C porphyrin on resin. ADVS, 12(14), 2409771. (www)

  @article{ , abstract = {Peptide multifunctionalization is a crucial technique to develop peptide-based agents for various purposes. Porphyrin-peptide conjugates are a class of popular multifunctional peptides renowned for their multifunctional and multimodal properties. However, the tedious synthetic works for porphyrin building blocks are involved in most previous studies. In this work, a modular solid-phase synthetic approach is reported to construct trans -AB 2 C porphyrin on peptide chains without presynthesized porphyrin building blocks. The products from this approach, which inherit both functionalities from the porphyrins and the modules employed for constructing porphyrins, show potential in biomedical and biomaterial applications. Furthermore, by extending this synthetic approach, the first example of “resin-to-resin” reaction is reported to link two peptides together along the construction of porphyrin motifs to give porphyrin-peptide conjugates with two different peptide chains.}, archive = {J_ADVS}, author = {Yue Wu and Yuen-Ting Wong and Yik-Hoi Yeung and Pak-Lun Lam and Ho-Fai Chau and Wing-Sze Tam and Qian Zhang and William C. S. Tai and Ka-Leung Wong}, doi = {10.1002/advs.202409771}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2409771}, shortjournal = {Adv. Sci.}, title = {Peptide multifunctionalization via modular construction of trans-AB2C porphyrin on resin}, volume = {12}, year = {2025}, }
• (2025). Burn-induced gut microbiota dysbiosis aggravates skeletal muscle atrophy by tryptophan-kynurenine mediated AHR pathway activation. ADVS, 12(14), 2409296. (www)

  @article{ , abstract = {The hypermetabolic response associated with burns is characterized by skeletal muscle atrophy and an increased incidence of disability and death. Significant remodeling of the gut microbiota occurs after severe burn trauma. However, the specific mechanisms by which gut microbiota contribute to burn-induced muscle atrophy remain unexplored. The results showed that the disruption of the gut microbiota exacerbated skeletal muscle atrophy. Fecal metabolite analysis revealed perturbations, primarily within the tryptophan (Trp) metabolic pathway. Animal models further demonstrated that gut microbiota disorder enhanced the expression of indoleamine 2,3-dioxygenase 1 (IDO-1) in the colon, ultimately resulting in Trp depletion and increased kynurenine (Kyn) levels in the serum and skeletal muscle. Excessive colonic Kyn is released into circulation, transported into skeletal muscle cells, and binds to the aryl hydrocarbon receptor (AHR), consequently triggering AHR nuclear translocation and initiating the transcription of skeletal muscle atrophy-related genes. Notably, serum samples from patients with burns exhibited Trp depletion, and Trp supplementation alleviated skeletal muscle atrophy in rats with burns. This study, for the first time, demonstrates that gut microbiota dysbiosis upregulates colonic IDO-1, promotes Trp-Kyn metabolism, and exacerbates burn-induced skeletal muscle atrophy, suggesting that Trp supplementation may be a potential therapeutic strategy.}, archive = {J_ADVS}, author = {Shan Gao and Yan Leng and Zhen Qiu and Kai Li and Jun Li and Jian Peng and Weiguo Xie and Shaoqing Lei and Zhongyuan Xia}, doi = {10.1002/advs.202409296}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2409296}, shortjournal = {Adv. Sci.}, title = {Burn-induced gut microbiota dysbiosis aggravates skeletal muscle atrophy by tryptophan-kynurenine mediated AHR pathway activation}, volume = {12}, year = {2025}, }
• (2025). Staphylococcus aureus tames nociceptive neurons to suppress synovial macrophage responses for sustained infection in septic arthritis. ADVS, 12(14), 2409251. (www)

  @article{ , abstract = {The interaction between the nervous system and immune system during chronic bacterial infection remains unclear. Here, it is reported that Staphylococcus aureus ( S. aureus ) infection induces calcitonin gene-related peptide (CGRP) secretion from intra-articular transient receptor potential cation channel subfamily V member 1 positive (TRPV1 + ) nociceptive nerves through its pore-forming toxin (PFT) α-hemolysin. The released CGRP then inhibits the production of chemotactic cytokines by CX3CR1 + tissue-resident synovial lining macrophages via receptor activity modifying protein 1 (RAMP1) receptors at the onset of septic arthritis. During the subsequent chronic course of infection, the continuous release of CGRP triggered by pain has a lasting effect on the antimicrobial capabilities of macrophages, thereby promoting bacterial survival and joint damage. This evidence suggests a critical role for neuroimmune regulation in S. aureus- induced chronic septic arthritis. CGRP receptor antagonism may reduce joint destruction, thus providing a new option for treating bone and joint infections.}, archive = {J_ADVS}, author = {Xinyu Fang and Yang Chen and Haiqi Ding and Changyu Huang and Hongxin Hu and Chaofan Zhang and Yunzhi Lin and Qijin Wang and Xueni Hu and Yiming Lin and Yongfa Chen and Nanxin Zhang and Xuhui Yuan and Ying Huang and Wenbo Li and Susheng Niu and Jianhua Lin and Bin Yang and Tifei Yuan and Wenming Zhang}, doi = {10.1002/advs.202409251}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2409251}, shortjournal = {Adv. Sci.}, title = {Staphylococcus aureus tames nociceptive neurons to suppress synovial macrophage responses for sustained infection in septic arthritis}, volume = {12}, year = {2025}, }
• (2025). TIA1-mediated stress granules promote the neuroinflammation and demyelination in experimental autoimmune encephalomyelitis through upregulating IL-31RA signaling. ADVS, 12(14), 2409086. (www)

  @article{ , abstract = {The dysfunction of stress granules (SGs) plays a crucial role in the pathogenesis of various neurological disorders, with T cell intracellular antigen 1 (TIA1) being a key component of SGs. However, the role and mechanism of TIA1-mediated SGs in experimental autoimmune encephalomyelitis (EAE) remain unclear. In this study, upregulation of TIA1, its translocation from the nucleus to the cytoplasm, and co-localization with G3BP1 (a marker of SGs) are observed in the spinal cord neurons of EAE mice. Deletion of TIA1 in the CNS alleviates neuroinflammation, suppresses demyelination and axonal damage, and reduces neuronal loss in EAE mice. Furthermore, alleviation of autophagy dysfunction and reduction of chronic persistent SGs are observed in Tia1 Nestin -CKO EAE mice. Mechanistically, IL-31RA levels are decreased in Tia1 Nestin -CKO EAE mice, which inhibit the downstream PI3K/AKT signaling pathway associated with IL-31RA, thereby enhancing autophagy and suppressing the NF-κB signaling pathway, further alleviating EAE symptoms. Knockdown of TIA1 in primary neurons and N2a cells treated with sodium arsenite also reduces the formation of SGs. These findings reveal an unrecognized role of TIA1-mediated SGs in promoting neuroinflammation and demyelination, offering novel therapeutic targets for MS.}, archive = {J_ADVS}, author = {Xin Hua and Lingting Jin and Zheyu Fang and Yiyun Weng and Yuan Zhang and Jingjing Zhang and Dewei Xie and Yang Tang and Siyu Guo and Yingying Huang and Yilin Dai and Jia Li and Zhihui Huang and Xu Zhang}, doi = {10.1002/advs.202409086}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2409086}, shortjournal = {Adv. Sci.}, title = {TIA1-mediated stress granules promote the neuroinflammation and demyelination in experimental autoimmune encephalomyelitis through upregulating IL-31RA signaling}, volume = {12}, year = {2025}, }
• (2025). Super-resolution imaging of nanoscale inhomogeneities in hBN-covered and encapsulated few-layer graphene. ADVS, 12(14), 2409039. (www)

  @article{ , abstract = {Encapsulating few-layer graphene (FLG) in hexagonal boron nitride (hBN) can cause nanoscale inhomogeneities in the FLG, including changes in stacking domains and topographic defects. Due to the diffraction limit, characterizing these inhomogeneities is challenging. Recently, the visualization of stacking domains in encapsulated four-layer graphene (4LG) has been demonstrated with phonon polariton (PhP)-assisted near-field imaging. However, the underlying coupling mechanism and ability to image subdiffractional-sized inhomogeneities remain unknown. Here, direct replicas and magnified images of subdiffractional-sized inhomogeneities in hBN-covered trilayer graphene (TLG) and encapsulated 4LG, enabled by the hyperlensing effect, are retrieved. This hyperlensing effect is mediated by hBN's hyperbolic PhP that couple to the FLG's plasmon polaritons. Using near-field microscopy, the coupling is identified by determining the polariton dispersion in hBN-covered TLG to be stacking-dependent. This work demonstrates super-resolution and magnified imaging of inhomogeneities, paving the way for the realization of homogeneous encapsulated FLG transport samples to study correlated physics.}, archive = {J_ADVS}, author = {Lina Jäckering and Konstantin G. Wirth and Lukas Conrads and Jonas B. Profe and Alexander Rothstein and Hristiyana Kyoseva and Kenji Watanabe and Takashi Taniguchi and Dante M. Kennes and Christoph Stampfer and Lutz Waldecker and Thomas Taubner}, doi = {10.1002/advs.202409039}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2409039}, shortjournal = {Adv. Sci.}, title = {Super-resolution imaging of nanoscale inhomogeneities in hBN-covered and encapsulated few-layer graphene}, volume = {12}, year = {2025}, }
• (2025). Adaptive deployable structure enabled by actively controlled tensegrity for space debris removal. ADVS, 12(14), 2408617. (www)

  @article{ , abstract = {The Earth's orbital environment is increasingly congested with space debris, posing a substantial risk to space operations and safety. Current mitigation strategies are primarily tailored to either small debris, through protective devices, or large debris, via spacecraft deorbiting methods, leaving medium-sized debris (0.4–10 cm) as a significant unaddressed threat. This study introduces an innovative adaptive deployable structure, utilizing actively controlled tensegrity, designed specifically for the removal of medium debris. The basic configuration and deployment process of the structure is detailed, followed by an analysis of key structural parameters affecting its folding and deployment performance. Additionally, the load-bearing capacity and impact resistance of the structure when integrated with a mesh fabric are evaluated. The optimal parameters and morphology for effective debris removal are identified, culminating in the construction of a 1:20 scale prototype for experimental validation. This structure not only adapts its configuration based on operational needs but also withstands impacts from space debris, thereby playing a crucial role in enhancing orbital safety.}, archive = {J_ADVS}, author = {Endong Shang and Ao Li and Md Shariful Islam and Li-Yuan Zhang and Changyong (Chase) Cao}, doi = {10.1002/advs.202408617}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2408617}, shortjournal = {Adv. Sci.}, title = {Adaptive deployable structure enabled by actively controlled tensegrity for space debris removal}, volume = {12}, year = {2025}, }
• (2025). Ultra-tough Copper–Copper bonding by nano-oxide-dispersed copper nanomembranes. ADVS, 12(14), 2408302. (www)

  @article{ , abstract = {Metal–metal bonding has played a pivotal role in advancing human technologies across various industrial sectors. As devices continue to miniaturize, there is an increasing need for efficient bonding techniques capable of achieving metal–metal bonds at smaller length scales. In this study, a facile but effective bonding technique is developed that enables the bonding of randomly oriented copper with copper nanomembranes under low temperatures and pressures. The fabricated copper nanomembranes, with a thickness of ≈50 nm and a width of 1 cm or above, exhibit a unique heterogeneous nanostructure, comprising copper nanocrystals along with nano-copper-oxide dispersions. Consequently, these copper nanomembranes display exceptional mechanical properties, including an ultra-low elastic modulus of ≈35 GPa, a remarkable yield strength of ≈1 GPa, and excellent ductility of ≈40%, overcoming the conventional strength-ductility trade-off observed in various copper alloys. Most importantly, these ultra-soft copper nanomembranes serve as metallic “glues”, promoting grain growth across the bonding interface between randomly oriented copper surfaces. This process leads to an average interfacial shear strength of up to 73 MPa at room temperature, representing an approximate 35 times increase in bonding strength compared to direct copper–copper bonding achieved under identical temperature and pressure conditions.}, archive = {J_ADVS}, author = {Yun Teng and Wenqing Zhu and Qing Wang and Zhibo Zhang and Hang Wang and Baisong Guo and Ziyin Yang and Hao Gong and Chuan He and Boxi Qu and Shien-Ping Feng and Yong Yang}, doi = {10.1002/advs.202408302}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2408302}, shortjournal = {Adv. Sci.}, title = {Ultra-tough Copper–Copper bonding by nano-oxide-dispersed copper nanomembranes}, volume = {12}, year = {2025}, }
• (2025). Pericytes promote more vascularization than stromal cells via an interleukin-6-dependent mechanism in microfluidic chips. ADVS, 12(14), 2408131. (www)

  @article{ , abstract = {Pericytes are a key player in vascularization, protecting endothelial cells from external harm and promoting the formation of new vessels when necessary. However, pericytic identity and its relationship with other cell types, such as mesenchymal stromal/stem cells, is highly debated. This study compares the role of pericytes and unselected stromal cells in vascularization using multichannel microfluidic chips. In both angiogenesis and vasculogenesis, pericytes promote more vessel formation than stromal cells. Pericytes can wrap around endothelial vessels acting as mural cells, while stromal cells remain separated. Whole-transcriptome sequencing confirms an upregulation of pro-vascularization genes in endothelial cell-pericyte co-cultures, while metabolism increases and inflammation decreases in stromal cell co-cultures. Treatment of stromal-endothelial cell co-cultures with either conditioned media or isolated extracellular vesicles from pericytes replicates the increase in vasculogenesis of the direct co-cultures. Cytokine quantification reveals that interleukin 6 (IL-6) is significantly increased in pericyte conditions. Blocking it with siltuximab results in a reduction of pericyte vasculogenic potential comparable to stromal cell levels, revealing that pericyte pro-vascularization is mediated by IL-6. This study provides new insights into the relationship between pericytes and endothelial cells and the elusive identity of mesenchymal stromal cells. These findings are relevant for both vascular biology and tissue engineering.}, archive = {J_ADVS}, author = {Julian Gonzalez-Rubio and Hannah Kubiza and Yong Xu and Hiltrud Koenigs-Werner and Mona Sophie Schmitz and Michaela Schedel and Christian Apel and Stefan Jockenhoevel and Christian G. Cornelissen and Anja Lena Thiebes}, doi = {10.1002/advs.202408131}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2408131}, shortjournal = {Adv. Sci.}, title = {Pericytes promote more vascularization than stromal cells via an interleukin-6-dependent mechanism in microfluidic chips}, volume = {12}, year = {2025}, }
• (2025). Tailoring crystal growth regulation and dual passivation for air-processed efficient perovskite solar cells. ADVS, 12(14), 2407401. (www)

  @article{ , abstract = {Hybrid metal halide perovskite solar cells (PSCs) are emerging as highly competitive next-generation photovoltaics due to their excellent performance and low production cost. However, the construction of high-efficiency PSCs typically requires an inert nitrogen environment within a glove box, inadvertently increasing manufacturing costs and hindering the transition from lab-scale to industrial-scale production. In this work, an air ambient fabrication of pure α-phase FAPbI 3 PSCs with high-efficiency and stability, utilizing a dual-functional engineering strategy assisted by 3-Guanidinopropionicacid (3-GuA) is reported. 3-GuA assists in managing excess PbI 2 and promotes the formation of high-quality FAPbI 3 films via intermolecular exchange. Simultaneously, the existence of 3-GuA minimizes the defects and stabilizes the resulting perovskite films. As a result, the ambient-air fabricated PSCs achieve a power conversion efficiency (PCE) of 24.2% with negligible hysteresis and excellent stability. Additionally, these devices demonstrate superior reproducibility, offering valuable guidance for future advancements in this technology.}, archive = {J_ADVS}, author = {Qianyi Li and Dongyang Li and Zhiqi Li and Qiong Liang and Patrick W. K. Fong and Yu Han and Kuan Liu and Jiangsheng Yu and Peng Bai and Tao Zhu and Yang Bai and Guang Yang and Zhiwei Ren and Gang Li}, doi = {10.1002/advs.202407401}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2407401}, shortjournal = {Adv. Sci.}, title = {Tailoring crystal growth regulation and dual passivation for air-processed efficient perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Adenosine monophosphate improves lipolysis in obese mice by reducing DNA methylation via ADORA2A activation by ecto-5′-nucleotidase (CD73). ADVS, 12(14), 2405079. (www)

  @article{ , abstract = {The previous work discovers the potential of adenosine monophosphate (AMP) to alleviate obesity-related metabolic diseases, but the underlying molecular mechanisms remain incompletely understood. Here, AMP is confirmed to enhance white fat decomposition and improve abnormal glucose and lipid metabolism in mice fed with a high-fat (HF) diet. Mechanically, AMP is converted to adenosine (ADO) through ecto-5′-nucleotidase (CD73), and adenosine A2A receptor (ADORA2A) signaling activation is involved in the down-regulation of methylation in white adipose tissue, thereby reducing the hormone-sensitive lipase (HSL) methylation level and promoting HSL transcription and white fat decomposition. Moreover, the metabolic benefits of AMP are found to be partially eliminated in ADORA2A knockout mice, but re-expression of ADORA2A can reproduce the AMP-induced metabolic regulation in white fat. These findings reveal the mechanism that AMP, as the upstream of ADO, stimulates ADORA2A signaling and white fat DNA methylation to participate in the anti-obesity effect.}, archive = {J_ADVS}, author = {Zhijuan Cui and Li Feng and Sujuan Rao and Zihao Huang and Shuangbo Huang and Liudan Liu and Yuan Liao and Zheng Lan and Qiling Chen and Jinping Deng and Leli Wang and Yulong Yin and Chengquan Tan}, doi = {10.1002/advs.202405079}, journal = {Advanced Science}, month = {4}, number = {14}, pages = {2405079}, shortjournal = {Adv. Sci.}, title = {Adenosine monophosphate improves lipolysis in obese mice by reducing DNA methylation via ADORA2A activation by ecto-5′-nucleotidase (CD73)}, volume = {12}, year = {2025}, }
• (2025). High-efficiency, long-lifetime and color-tunable hybrid WOLEDs using a platinum complex with voltage-dependent monomer and aggregate emission (Adv. sci. 13/2025). ADVS, 12(13), 2570092. (www)

  @article{ , archive = {J_ADVS}, author = {Yangyang Xin and Mao Mao and Shuo Xu and Kaixin Tan and Gang Cheng and Hai Zhang and Hengyi Dai and Tianyu Huang and Dongdong Zhang and Lian Duan and Chi-Ming Che}, doi = {10.1002/advs.202570092}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2570092}, shortjournal = {Adv. Sci.}, title = {High-efficiency, long-lifetime and color-tunable hybrid WOLEDs using a platinum complex with voltage-dependent monomer and aggregate emission (Adv. sci. 13/2025)}, volume = {12}, year = {2025}, }
• (2025). Structural basis and mechanism of a unique haemophore in the haem-iron acquisition by riemerella anatipestifer (Adv. sci. 13/2025). ADVS, 12(13), 2570091. (www)

  @article{ , archive = {J_ADVS}, author = {Mengying Wang and Dandan Zhang and Xiu Tian and Jiangyang Tong and Yizhou Yao and Mingshu Wang and Dekang Zhu and Renyong Jia and Shun Chen and Xinxin Zhao and Shaqiu Zhang and Juan Huang and Xumin Ou and Bin Tian and Di Sun and Yu He and Zhen Wu and Songying Ouyang and Mafeng Liu and Anchun Cheng}, doi = {10.1002/advs.202570091}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2570091}, shortjournal = {Adv. Sci.}, title = {Structural basis and mechanism of a unique haemophore in the haem-iron acquisition by riemerella anatipestifer (Adv. sci. 13/2025)}, volume = {12}, year = {2025}, }
• (2025). Metabolic engineering of corynebacterium glutamicum for high-level production of 1,5-pentanediol, a c5 diol platform chemical (Adv. sci. 13/2025). ADVS, 12(13), 2570090. (www)

  @article{ , archive = {J_ADVS}, author = {Yu Jung Sohn and Se-Yeun Hwang and Haeyoung Lee and Subeen Jeon and Ji Young Park and Jaehyung Kim and Donghyuk Kim and Ki Jun Jeong and Sang Yup Lee and Jeong Chan Joo and Jin-Byung Park and Si Jae Park}, doi = {10.1002/advs.202570090}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2570090}, shortjournal = {Adv. Sci.}, title = {Metabolic engineering of corynebacterium glutamicum for high-level production of 1,5-pentanediol, a c5 diol platform chemical (Adv. sci. 13/2025)}, volume = {12}, year = {2025}, }
• (2025). Deletion of pyruvate carboxylase in tubular epithelial cell promotes renal fibrosis by regulating SQOR/cGAS/STING-mediated glycolysis (Adv. sci. 13/2025). ADVS, 12(13), 2570088. (www)

  @article{ , archive = {J_ADVS}, author = {Hao Huang and Yuanyuan Han and Yan Zhang and Jianhua Zeng and Xin He and Jiawei Cheng and Songkai Wang and Yiwei Xiong and Hongling Yin and Qiongjing Yuan and Ling Huang and Yanyun Xie and Jie Meng and Lijian Tao and Zhangzhe Peng}, doi = {10.1002/advs.202570088}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2570088}, shortjournal = {Adv. Sci.}, title = {Deletion of pyruvate carboxylase in tubular epithelial cell promotes renal fibrosis by regulating SQOR/cGAS/STING-mediated glycolysis (Adv. sci. 13/2025)}, volume = {12}, year = {2025}, }
• (2025). D2HGDH deficiency regulates seizures through GSH/Prdx6/ROS-mediated excitatory synaptic activity (Adv. sci. 13/2025). ADVS, 12(13), 2570087. (www)

  @article{ , archive = {J_ADVS}, author = {Zhijuan Zhang and Hui Zhang and Peng Zhang and Rong Li and Jinyu Zhou and Jiyuan Li and Danmei Hu and Rui Huang and Fenglin Tang and Jie Liu and Demei Xu and Chenlu Zhang and Xin Tian and Yuanlin Ma and Patrick Kwan}, doi = {10.1002/advs.202570087}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2570087}, shortjournal = {Adv. Sci.}, title = {D2HGDH deficiency regulates seizures through GSH/Prdx6/ROS-mediated excitatory synaptic activity (Adv. sci. 13/2025)}, volume = {12}, year = {2025}, }
• (2025). IRAP drives ribosomal degradation to refuel energy for platelet activation during septic thrombosis (Adv. sci. 13/2025). ADVS, 12(13), 2570086. (www)

  @article{ , archive = {J_ADVS}, author = {Baichuan Xu and Xianpeng Ye and Kangfu Sun and Liang Chen and Zhaoyang Wen and Qigang Lan and Jun Chen and Mo Chen and Mingqiang Shen and Song Wang and Yang Xu and Xi Zhang and Jinghong Zhao and Junping Wang and Shilei Chen}, doi = {10.1002/advs.202570086}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2570086}, shortjournal = {Adv. Sci.}, title = {IRAP drives ribosomal degradation to refuel energy for platelet activation during septic thrombosis (Adv. sci. 13/2025)}, volume = {12}, year = {2025}, }
• (2025). ODSEI chip: An open 3D microfluidic platform for studying tumor spheroid-endothelial interactions (Adv. sci. 13/2025). ADVS, 12(13), 2570085. (www)

  @article{ , archive = {J_ADVS}, author = {Jooyoung Ro and Junyoung Kim and Juhee Park and Yongjun Choi and Yoon-Kyoung Cho}, doi = {10.1002/advs.202570085}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2570085}, shortjournal = {Adv. Sci.}, title = {ODSEI chip: An open 3D microfluidic platform for studying tumor spheroid-endothelial interactions (Adv. sci. 13/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “Computed tomography imaging guided microenvironment-responsive Ir@WO3-x dual-catalytic nanoreactor for selective radiosensitization”. ADVS, 12(13), 2502913. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202502913}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2502913}, shortjournal = {Adv. Sci.}, title = {Correction to “Computed tomography imaging guided microenvironment-responsive Ir@WO3-x dual-catalytic nanoreactor for selective radiosensitization”}, volume = {12}, year = {2025}, }
• (2025). Correction to “[E2F2 reprograms macrophage function by modulating material and energy metabolism in the progression of metabolic dysfunction-associated steatohepatitis]”. ADVS, 12(13), 2502901. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202502901}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2502901}, shortjournal = {Adv. Sci.}, title = {Correction to “[E2F2 reprograms macrophage function by modulating material and energy metabolism in the progression of metabolic dysfunction-associated steatohepatitis]”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Extracellular vesicles from compression-loaded cementoblasts promote the tissue repair function of macrophages”. ADVS, 12(13), 2501438. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202501438}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2501438}, shortjournal = {Adv. Sci.}, title = {Correction to “Extracellular vesicles from compression-loaded cementoblasts promote the tissue repair function of macrophages”}, volume = {12}, year = {2025}, }
• (2025). A synthetic facultative CAM-like shuttle in c3 rice plants. ADVS, 12(13), 2500418. (www)

  @article{ , abstract = {Crassulacean acid metabolism (CAM) is one of the three major forms of photosynthesis, known for its efficient carbon sequestration mechanism. CAM plants store malate at night, which undergoes decarboxylation and promotes Rubisco carboxylation during the day. Despite its potential benefits, CAM engineering is not applied to C 3 crops. This paper introduces a designed facultative CAM bypass (CBP) in rice by incorporating codon-optimized nocturnal carboxylation and decarboxylation modules, a malate transporter module, and a stomatal regulation module using the transgene stacking system. The CBP plants are correctly assembled by detection at the gene level, transcription level, protein level, and enzyme activity. Malate, CAM metabolism product, accumulated significantly at night in CBP plants. Metabolic analysis revealed that the malate is directed to the citric acid cycle and impacted carbon sequestration. The CBP plants showed a significant increase of ≈21% and ≈27% in photosynthetic rate and carboxylation efficiency, respectively. Additionally, CBP plants exhibited ≈20% increase in grain yield and biomass over the 2-year field trials. Unexpectedly, the water use efficiency and drought resistance do not improve in CBP plants. This study is the first to attempt CAM engineering in C 3 and demonstrates the potential of facultative CAM carbon sequestration in rice.}, archive = {J_ADVS}, author = {Suting Wu and Kaining Jin and Haoshu Li and Guoxin Chen and Liying Zhang and Jinwen Yang and Shanshan Zhai and Yanni Li and Xuehui Sun and Xuean Cui and Jing Sun and Tiegang Lu and Zhiguo Zhang}, doi = {10.1002/advs.202500418}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2500418}, shortjournal = {Adv. Sci.}, title = {A synthetic facultative CAM-like shuttle in c3 rice plants}, volume = {12}, year = {2025}, }
• (2025). Hybrid electro-optical stimulation improves ischemic brain damage by augmenting the glymphatic system. ADVS, 12(13), 2417449. (www)

  @article{ , abstract = {Ischemic brain injury not only results in significant neurological, motor, and cognitive impairment but also contributes to the accumulation of toxic solutes and proinflammatory cytokines in the infarction region, exacerbating ischemic brain damage. The glymphatic system, which is crucial for brain waste clearance and homeostasis, is impaired by ischemic injury, highlighting the importance of developing therapeutic strategies for poststroke complications. Herein, a novel hybrid electro-optical stimulation device is proposed that integrates near-infrared micro-light-emitting diode with transparent microneedles, enabling efficient noninvasive stimulation of the cortical area for ischemic stroke treatment. This study investigates whether this hybrid electro-optical stimulation enhances the glymphatic system function and ameliorates ischemic brain injury in the middle cerebral artery occlusion and reperfusion (MCAO/R) mice model. The results demonstrate that hybrid stimulation improves the neurological, motor, and cognitive functions and reduces brain atrophy following MCAO/R. Moreover, hybrid stimulation restores impaired glymphatic system function by modulation of aquaporin-4 (AQP4) polarization and alleviates the accumulation of proinflammatory cytokines such as IL-1β. Notably, AQP4 inhibition partly reverses the improved functional outcomes of hybrid stimulation. The findings suggest that targeting glymphatic drainage using hybrid electro-optical stimulation is a promising therapeutic approach for treating ischemic brain injury.}, archive = {J_ADVS}, author = {Min Jae Kim and Jiman Youn and Hong Ju Lee and Seo-Yeon Lee and Tae-Gyu Kim and Young-Jin Jung and Yong-Il Shin and Byung Tae Choi and Joonsoo Jeong and Hwa Kyoung Shin}, doi = {10.1002/advs.202417449}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2417449}, shortjournal = {Adv. Sci.}, title = {Hybrid electro-optical stimulation improves ischemic brain damage by augmenting the glymphatic system}, volume = {12}, year = {2025}, }
• (2025). Response to the comment on “Atom-modified gDNA enhances cleavage activity of TtAgo enabling ultra-sensitive nucleic acid testing”. ADVS, 12(13), 2417344. (www)

  @article{ , archive = {J_ADVS}, author = {Miaomiao Chen and Xinxin Li and Wenwen Wu and Siyue Lu and Zixiang Liu and Xiaolan Guo and Guangcheng Luo}, doi = {10.1002/advs.202417344}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2417344}, shortjournal = {Adv. Sci.}, title = {Response to the comment on “Atom-modified gDNA enhances cleavage activity of TtAgo enabling ultra-sensitive nucleic acid testing”}, volume = {12}, year = {2025}, }
• (2025). Electronic modulation and built-in electric field strategies in heterostructures together induce 1T-rich MoS2 conversion for advanced sodium storage. ADVS, 12(13), 2417288. (www)

  @article{ , abstract = {1T-MoS 2 is considered an attractive energy storage material due to its large layer spacing and excellent electrical conductivity. Unfortunately, 1T-MoS 2 is difficult to synthesize directly due to the substability, which limits its development and application. Electron-filling engineering of Mo 4d orbitals is the core idea to induce an efficient conversion of 2H to 1T phase. Based on this theory, a homogeneous CuS@MoS 2 heterogeneous nanosheet is successfully constructed based on electron-rich CuS as an electron donor. Both density functional theory (DFT) and X-ray absorption fine structure analysis (XAFS) illustrate that part of the electrons from Cu at the heterogeneous interface are transferred to Mo, which triggers the reorganization of Mo 4d orbitals and the formation of a strong built-in electric field at the interface, and induces an irreversible phase transition from 2H to 1T in MoS 2 . Based on its structural features, CuS@MoS 2 heterogeneous nanosheets have a high first discharge capacity of 725 mAh g −1 at 0.1 A g −1 , excellent rate performance (466.73 mAh g −1 at 10 A g −1 ), and long cycle stability (506.03 mAh g −1 after 3200 cycles at 5 A g −1 ). This work provides new perspectives for the development of high-performance sodium storage anode materials based on 1T-rich MoS 2 .}, archive = {J_ADVS}, author = {Hui Peng and Wenxing Miao and Jingtian Zeng and Zihao Wang and Chenhui Yan and Guofu Ma and Ziqiang Lei}, doi = {10.1002/advs.202417288}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2417288}, shortjournal = {Adv. Sci.}, title = {Electronic modulation and built-in electric field strategies in heterostructures together induce 1T-rich MoS2 conversion for advanced sodium storage}, volume = {12}, year = {2025}, }
• (2025). High-efficiency water collection of superhydrophobic condensation absorber. ADVS, 12(13), 2417024. (www)

  @article{ , abstract = {The atmosphere contains ≈1.3 billion tons vapor that can be condensed to obtain water, which has the promise of alleviating the water crisis. However, condensed droplets are difficult to shed from the condensation surface that means a low surface refreshing frequency, showing the low water collection rate and efficiency. Here, this limitation is successfully overcome by proposing a novel superhydrophobic condensation absorber (SCA). All surfaces of the SCA are superhydrophobic but covered with a series of superhydrophilic through pores and superhydrophilic points which enabled the SCA with a rapid droplet nucleation capability. The whole condensation processes exhibit that the SCA has  the extremely small droplet shedding volume and the highly frequent surface refreshing, which are 0.00003 and 1.1× 10 6 times that of the existing water collection method, respectively. The water collection rate of SCA is superior than that of the existing water collection methods, reaching to 80 mg cm −2 h −1 at the subcooling temperature of only 10 °C. In addition, the collected water by this SCA is clean without any contaminant. This high-efficiency and eco-friendly water collection method will maximize the acquisition of clean water from atmosphere, which has a strong implication for the people suffering from the freshwater crisis.}, archive = {J_ADVS}, author = {Defeng Yan and Junyi Lin and Yang Chen and Xiaolong Yang and Yao Lu and Jinlong Song}, doi = {10.1002/advs.202417024}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2417024}, shortjournal = {Adv. Sci.}, title = {High-efficiency water collection of superhydrophobic condensation absorber}, volume = {12}, year = {2025}, }
• (2025). Honokiol-magnolol-baicalin possesses synergistic anticancer potential and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancer by triggering GSDME-dependent pyroptosis. ADVS, 12(13), 2417022. (www)

  @article{ , abstract = {Significant progress is made in the treatment of metastatic colorectal cancer (mCRC) patients, however, therapeutic options remain limited for patients with mCRC. In recent years, traditional Chinese medicine (TCM) has gained significant attention. Among these, Huangqin Houpo decoction has demonstrated efficacy in mCRC treatment. Despite its promise, the active ingredients and mechanisms underlying its anticancer effects remain unclear. Using integrative pharmacological approaches, six compounds are identified as the primary active ingredients in Huangqin Houpo decoction. Among them, honokiol (H), magnolol (M), and baicalin (B) are found to exhibit a synergistic anticancer effect on CRC. The HMB combination significantly outperforms mono- or bi-agent treatments in reducing tumor growth. Furthermore, the anticancer efficacy of the HMB combination surpasses that of medium- and high-dose Huangqin Houpo decoction and the FOLFOX regimen. Notably, HMB is comparable in efficacy to the FOLFIRI regimen. Most importantly, HMB is shown to enhance the sensitivity of CRC cells to anti-PD-1 immunotherapy in vivo. Mechanistic studies reveal that the HMB combination exerts its synergistic anticancer effects and enhances anti-PD-1 immunotherapy by inducing GSDME-dependent pyroptosis. Our study will hopefully provide a potential therapeutic strategy for mCRC patients in the future. [Correction added on 25 February 2025, after first online publication: FOLFOIRI is changed to FOLFIRI.]}, archive = {J_ADVS}, author = {Quan Gao and Qinsong Sheng and Zijing Yang and ZhiYu Zhu and Lin Li and Lihui Xu and Jing Xia and Yunhao Qiao and Jie Gu and Xiaolong Zhu and Tian Xie and Xinbing Sui}, doi = {10.1002/advs.202417022}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2417022}, shortjournal = {Adv. Sci.}, title = {Honokiol-magnolol-baicalin possesses synergistic anticancer potential and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancer by triggering GSDME-dependent pyroptosis}, volume = {12}, year = {2025}, }
• (2025). Electrostatic co-assembly of cyanine pair for augmented photoacoustic imaging and photothermal therapy. ADVS, 12(13), 2416905. (www)

  @article{ , abstract = {Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging-guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high-contrast photoacoustic imaging and efficient therapeutic capabilities. In this work, a supramolecular strategy is employed to construct a molecular pair phototheranostic agent via the direct self-assembly of two cyanines, C5TNa (anionic) and Cy-Et (cationic). The Coulombic interactions between C5TNa and Cy-Et facilitate the formation of a complementary cyanine pair (C5T-ET) and the creation of supramolecular CT-J-type aggregates in water. This complementary cyanine pair (C5T-ET) results in completely quenched fluorescence and significantly enhances nonradiative deactivation (≈22 ps), leading to a 3.3-fold increase in photothermal conversion efficiency and a 7.1-fold enhancement in photoacoustic response compared to indocyanine green (ICG). As a result, the J-type aggregate cyanine pair (C5T-ET) demonstrates high photoacoustic imaging capability and remarkable antitumor phototheranostic efficacy in vivo, highlighting its potential for clinical applications. This work provides strong experimental evidence for the superior performance of the complementary cyanine pair (C5T-ET) in enhancing photosensitization and photoacoustic response. It is believed that this strategy will propel the advancement of controllable dye J-aggregates and contribute to the practical implementation of photoacoustic imaging and phototherapy in vivo.}, archive = {J_ADVS}, author = {Haiqiao Huang and Yingnan Wu and Xin He and Yahang Liu and Jing-Hui Zhu and Mingrui Gu and Danhong Zhou and Saran Long and Yahui Chen and Lei Wang and Mingle Li and Xiaoqiang Chen and Xiaojun Peng}, doi = {10.1002/advs.202416905}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2416905}, shortjournal = {Adv. Sci.}, title = {Electrostatic co-assembly of cyanine pair for augmented photoacoustic imaging and photothermal therapy}, volume = {12}, year = {2025}, }
• (2025). A spatially distributed microneedle system for bioorthogonal t cell-guided cancer therapy. ADVS, 12(13), 2416841. (www)

  @article{ , abstract = {Chimeric antigen receptor (CAR)-T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and the poor infiltration of CAR-T cells significantly hinder the efficacy of CAR-T therapies against tumors. Here, a spatially distributed microneedle system (SDMNS) is developed that leverages bioorthogonal reactions to activate and guide endogenous T cells to tumors for effective destruction. The SDMNS consists of two dissolving microneedles, each loaded with complementary bioorthogonal groups and applied separately to lymph nodes and tumor sites. One microneedle loaded with two dibenzocyclooctyne (DBCO)-modified antibodies activates T cells and labels them with bioorthogonal groups in lymph nodes. The other microneedle, containing N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) for glycometabolic labeling of tumor cells, and the T cell chemotactic factor IP10, is applied directly to the tumor site. The in vivo studies demonstrate that SDMNS effectively directs the migration and infiltration of endogenous activated T cells into the tumors. Through a bioorthogonal click reaction, DBCO-modified T cells conjugate with azide (N 3 )-modified tumor cells, eliciting robust antitumor immune responses and durable immune memory. The SDMNS offers a novel strategy to overcomes tumor heterogeneity by facilitating the directed migration of endogenous T cells.}, archive = {J_ADVS}, author = {Lanya Li and Fei Wang and Shushan Mo and Junyao Deng and Xueyi Wang and Jiacong Ai and Yingxian Xiao and Yan Zeng and Qishan Li and Yixin Zhang and Limin Cai and Zhenhua Li}, doi = {10.1002/advs.202416841}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2416841}, shortjournal = {Adv. Sci.}, title = {A spatially distributed microneedle system for bioorthogonal t cell-guided cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Fundamentals and applications of dual-frequency magnetic particle spectroscopy: Review for biomedicine and materials characterization. ADVS, 12(13), 2416838. (www)

  @article{ , abstract = {Superparamagnetic nanoparticles (MNP) offer exciting applications for engineering and biomedicine in imaging, diagnostics, and therapy upon magnetic excitation. Specifically, if excited at two distinct frequencies f 1 and f 2 , MNP responds with magnetic intermodulation frequencies m · f 1 ± n · f 2 caused by their nonlinear magnetization. These mixing frequencies are highly specific for MNP properties, uniquely characterizing their presence. In this review, the fundamentals of frequency mixing magnetic detection (FMMD) as a special case of magnetic particle spectroscopy (MPS) are reviewed, elaborating its functional principle that enables a large dynamic range of detection of MNP. Mathematical descriptions derived from Langevin modeling and micromagnetic Monte-Carlo simulations show matching predictions. The latest applications of FMMD in nanomaterials characterization as well as diagnostic and therapeutic biomedicine are highlighted: analysis of the phase of the FMMD signal characterizes the magnetic relaxation of MNP, allowing to determine hydrodynamic size and binding state. Variation of excitation amplitudes or magnetic offset fields enables determining the size distribution of the particles’ magnetic cores. This permits multiplex detection of polydisperse MNP in magnetic immunoassays, realized successfully for various biomolecular targets such as viruses, bacteria, proteins, and toxins. A portable magnetic reader enables portable immunodetection at point-of-care. Future applications toward theranostics are summarized and elaborated.}, archive = {J_ADVS}, author = {Hans-Joachim Krause and Ulrich M. Engelmann}, doi = {10.1002/advs.202416838}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2416838}, shortjournal = {Adv. Sci.}, title = {Fundamentals and applications of dual-frequency magnetic particle spectroscopy: Review for biomedicine and materials characterization}, volume = {12}, year = {2025}, }
• (2025). Progress in cu-based catalyst design for sustained electrocatalytic CO2 to c2+ conversion. ADVS, 12(13), 2416597. (www)

  @article{ , abstract = {The electrocatalytic conversion of CO 2 into valuable multi-carbon (C 2+ ) products using Cu-based catalysts has attracted significant attention. This review provides a comprehensive overview of recent advances in Cu-based catalyst design to improve C 2+ selectivity and operational stability. It begins with an analysis of the fundamental reaction pathways for C 2+ formation, encompassing both established and emerging mechanisms, which offer critical insights for catalyst design. In situ techniques, essential for validating these pathways by real-time observation of intermediates and material evolution, are also introduced. A key focus of this review is placed on how to enhance C 2+ selectivity through intermediates manipulation, particularly emphasizing catalytic site construction to promote C─C coupling via increasing * CO coverage and optimizing protonation. Additionally, the challenge of maintaining catalytic activity under reaction conditions is discussed, highlighting the reduction of active charged Cu species and materials reconstruction as major obstacles. To address these, the review describes recent strategies to preserve active sites and control materials evolution, including novel catalyst design and the utilization and mitigation of reconstruction. By presenting these developments and the challenges ahead, this review aims to guide future materials design for CO 2 conversion.}, archive = {J_ADVS}, author = {Dan Li and Jinyuan Liu and Bin Wang and Chao Huang and Paul K. Chu}, doi = {10.1002/advs.202416597}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2416597}, shortjournal = {Adv. Sci.}, title = {Progress in cu-based catalyst design for sustained electrocatalytic CO2 to c2+ conversion}, volume = {12}, year = {2025}, }
• (2025). Wearable self-powered pressure sensors based on alk-Ti3C2Tx regulating contact barrier difference for noncontact motion object recognition. ADVS, 12(13), 2416504. (www)

  @article{ , abstract = {Wearable self-powered pressure sensors present tremendous potential for object recognition. However, the fluctuated approach speed and distance may compromise the device output, thus affecting the recognition accuracy. Herein, a wearable self-powered pressure sensor with high sensitivity (1.48 V kPa −1 ), high output (130.5V), and high permeability (259.98 mm s −1 ) are developed where the contact barrier difference and triboelectric charge density of the triboelectric layer surface are dynamically regulated by modulating the surface groups resulting in a lower dielectric loss and higher output. The sensor leverages the polarity difference between the target object and the sensitive material to generate electrical signals at different speeds and distances through an electrostatic induction mechanism. With the assistance of the Transformer model with a self-attention mechanism, an average recognition accuracy of 94.3% is achieved by acquiring sensing signals at different speeds and distances. Simulating the ability of human vision, enables visually impaired people to acclimate to their surroundings more easily and independently and provides a critical advancement in the assistance of the blind with daily life.}, archive = {J_ADVS}, author = {Yanan Xiao and Qi Pu and Chenxing Wang and Xiaoteng Jia and Shixiang Sun and Quan Jin and Xiaolong Wang and Bin Wang and Peng Sun and Fangmeng Liu and Geyu Lu}, doi = {10.1002/advs.202416504}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2416504}, shortjournal = {Adv. Sci.}, title = {Wearable self-powered pressure sensors based on alk-Ti3C2Tx regulating contact barrier difference for noncontact motion object recognition}, volume = {12}, year = {2025}, }
• (2025). Simultaneous achievement of enhanced nonlinear optical absorption and nonlinear refraction in highly crystalline 2D covalent organic frameworks ultrathin films. ADVS, 12(13), 2416170. (www)

  @article{ , abstract = {Large enhancement of nonlinear absorption and nonlinear refraction are achieved simultaneously in highly ordered two dimensional (2D) covalent organic framework (COF) films prepared by solidliquid interface one-step method to overcome the weakness of COF powders in solubility. In the intrinsic nonlinear optical response obtained at 532 nm with 5 ns pulse, the nonlinear absorption coefficients (β) of two COF films are −4.87 × 10 −5 and −1.29 × 10 −5 m W −1 , respectively. Simultaneously, the fitted closed-aperture curves also show large nonlinear refractive indexes ( n 2 ), −5.62 × 10 −12 m 2 W −1 and −0.76 × 10 −12 m 2 W −1 . The 4f coherent imaging performed at the same condition with a single-shot pulse further verifies the outstanding nonlinear optical response without any damage probably experienced in the Z-scan technique. Moreover, the differences in framework electronic structure and photoexcited states between two COF films are compared to explain the difference in nonlinear optical response. All the results indicate that two COF crystalline films with intrinsic giant nonlinear optical response can be capable of modulating both amplitude and phase of light, providing huge potential in all-optical manipulating and switching at the nanoscale as outstanding nonlinear optical materials.}, archive = {J_ADVS}, author = {Tianyang Dong and Xingyuan Wen and Junyi Li and Xingzhi Wu and Chong Wang and Wenfa Zhou and Lingmin Yu and Yinglin Song and Chunru Wang and Li Jiang and Chunli Bai}, doi = {10.1002/advs.202416170}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2416170}, shortjournal = {Adv. Sci.}, title = {Simultaneous achievement of enhanced nonlinear optical absorption and nonlinear refraction in highly crystalline 2D covalent organic frameworks ultrathin films}, volume = {12}, year = {2025}, }
• (2025). Structure-guided engineering of a versatile urethanase improves its polyurethane depolymerization activity. ADVS, 12(13), 2416019. (www)

  @article{ , abstract = {Polyurethane (PUR), the fifth most prevalent synthetic polymer, substantially contributes to the global plastic waste problem. Biotechnology-based recycling methods have recently emerged as innovative solutions to plastic waste disposal and sparked interest among scientific communities and industrial stakeholders in discovering and designing highly active plastic-degrading enzymes. Here, the ligand-free crystal structure of UMG-SP2, a metagenome-derived urethanase with depolymerization activities, at 2.59 Å resolution, as well as its (co-)structures bound to a suicide hydrolase inhibitor and a short-chain carbamate substrate at 2.16 and 2.40 Å resolutions, respectively, is reported. Structural analysis and molecular dynamics simulations reveal that the flexible loop L3 consisting of residues 219–226 is crucial for regulating the hydrolytic activity of UMG-SP2. The semi-rational redesign of UMG-SP2 reveals superior variants, A141G and Q399A, exhibiting over 30.7- and 7.4-fold increased activities on polyester-PUR and a methylene diamine derivative of PUR, respectively, compared to the wild-type enzyme. These findings advance the understanding of the structure–function relationship of PUR-hydrolyzing enzymes, which hold great promise for developing effective industrial PUR recycling processes and mitigating the environmental footprint of plastic waste.}, archive = {J_ADVS}, author = {Zhishuai Li and Xu Han and Lin Cong and Parinita Singh and Pedro Paiva and Yannick Branson and Wenshuo Li and Yangyang Chen and Da'san M. M. Jaradat and Frank Lennartz and Thomas Bayer and Louis Schmidt and Ulrike Garscha and Song You and Pedro Alexandrino Fernandes and Maria João Ramos and Uwe T. Bornscheuer and Gert Weber and Ren Wei and Weidong Liu}, doi = {10.1002/advs.202416019}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2416019}, shortjournal = {Adv. Sci.}, title = {Structure-guided engineering of a versatile urethanase improves its polyurethane depolymerization activity}, volume = {12}, year = {2025}, }
• (2025). Copper-catalyzed carbonylative cyclization of CO2: A promising approach for synthesis of flavone. ADVS, 12(13), 2415795. (www)

  @article{ , abstract = {Flavones are an important class of building blocks for numerous biologically active molecules, pharmaceuticals, and natural products. Reductive carbonylation of CO 2 is a powerful method to provide high-value heterocycles quickly. However, examples of transition metal-catalyzed carbonylation to produce flavones using CO 2 are quite scarce, and the related copper-catalyzed carbonylative cyclization of CO 2 is not reported. Here, a general procedure is developed for the copper-catalyzed carbonylative C(sp 3 )-H bond synthesis of flavone using CO 2 as the C1 source. Additionally, 13 C-labeled flavones are successfully synthesized using [ 13 C]-CO 2 , demonstrating significant inhibitor activity against MCF-7 cells in antitumor assays. Mechanistic investigations suggest that the phenolic group accelerates CO 2 mass transfer by promoting nucleophilic addition to DBU-CO 2 complexes, followed by selective intramolecular carbonylative cyclization.}, archive = {J_ADVS}, author = {Zijun Huang and Junyong Dong and Pengtao Liu and Yadi Yin and Bing Yi and Zhengjun Fang and Xiaolin Jiang and Yuehui Li}, doi = {10.1002/advs.202415795}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415795}, shortjournal = {Adv. Sci.}, title = {Copper-catalyzed carbonylative cyclization of CO2: A promising approach for synthesis of flavone}, volume = {12}, year = {2025}, }
• (2025). Dynamic assembly of microgels and polymers at non-aqueous Liquid/Liquid interfaces. ADVS, 12(13), 2415642. (www)

  @article{ , abstract = {Particle assembly at liquid–liquid interfaces presents a promising bottom-up strategy for creating supramolecular materials with advanced functionalities. However, the significantly lower interfacial tension observed in immiscible organic phases compared to traditional oil–water systems has hindered the effective adsorption and assembly of particles at oil–oil interfaces. In this work, a versatile and effective strategy is presented that utilizes the assembly and jamming of microgels and polymer ligands at non-aqueous liquid–liquid interfaces to create non-aqueous Pickering emulsions and reconfigurable droplet networks. The resulting microgel-polymer complexes form an asymmetric interfacial bilayer with high surface coverage, which effectively minimizes interfacial energy and improves interfacial elasticity. Through a combination of systematic interfacial measurements and molecular dynamics simulations, the underlying mechanisms governing interfacial self-assembly are elucidated. Notably, the stimuli-responsive nature of the microgel-polymer complexes allows for precise control over the interfacial assembly and disassembly by introducing competitive molecules. Furthermore, it is demonstrated that these non-aqueous Pickering emulsions serve as excellent templates for the fabrication of heterogeneous organogels and microgel-based colloidosomes through both covalent and non-covalent crosslinking strategies. This work underscores the potential of non-aqueous interfaces in advancing materials science and opens new avenues for developing multifunctional materials.}, archive = {J_ADVS}, author = {Xin Guan and Yang Liu and Lianwei Li and Man-Hin Kwok and Mingming Ding and Hang Jiang and To Ngai}, doi = {10.1002/advs.202415642}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415642}, shortjournal = {Adv. Sci.}, title = {Dynamic assembly of microgels and polymers at non-aqueous Liquid/Liquid interfaces}, volume = {12}, year = {2025}, }
• (2025). The toxicity of lead and lead-free perovskite precursors and nanocrystals to human cells and aquatic organisms. ADVS, 12(13), 2415574. (www)

  @article{ , abstract = {Halide perovskites have emerged at the forefront of semiconductor materials for photovoltaic and light-emitting devices. However, long-term stability and toxicity are the major barriers to their commercialization. In particular, the toxicity of lead (Pb) and its environmental impact have prompted the exploration of lead-free alternatives like tin (Sn) and bismuth (Bi). Herein, a cytotoxicity study of Pb-based perovskite (CsPbBr 3 and CsPbI 3 ) and a lead-free Cs 2 AgBiBr 6 nanocrystals in lung and liver cell lines and in blood cells are reported, revealing that both Pb and Bi exhibit mitogenic effects and oxidative stress in liver cells, cytotoxicity in pulmonary cells and a dose-dependent hemolytic effect, raising concerns about their potential pulmonary-hepato-hemotoxicity. The zebrafish embryo tests reveal SnBr 2 displays a notably safer environmental impact profile at elevated concentrations, while Pb and Bi exhibit dose-dependent toxicity. This study provides compelling evidence that Sn compounds demonstrate a safer toxicity profile in both human cells and aquatic organisms under the studied conditions, supporting their potential as a more environmentally friendly alternative. In contrast, Bi compounds exhibit a toxicity profile similar to Pb perovskites, warranting caution in its use as a substitute. These findings guide future research and regulatory efforts in the safety and sustainability of perovskite nanocrystals.}, archive = {J_ADVS}, author = {Immacolata Maietta and Clara Otero-Martínez and Sabela Fernández and Laura Sánchez and África González-Fernández and Lakshminarayana Polavarapu and Rosana Simón-Vázquez}, doi = {10.1002/advs.202415574}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415574}, shortjournal = {Adv. Sci.}, title = {The toxicity of lead and lead-free perovskite precursors and nanocrystals to human cells and aquatic organisms}, volume = {12}, year = {2025}, }
• (2025). Bioactive inorganic materials for innervated multi-tissue regeneration. ADVS, 12(13), 2415344. (www)

  @article{ , abstract = {Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated tissues still poses significant challenges due to the lack of concerns of tissue innervation. Design rationale of multifunctional biomaterials with both tissue-induction and neural induction activities shows great potential for functional tissue regeneration. Recently, the research and application of inorganic biomaterials attracts increasing attention in innervated multi-tissue regeneration, such as central nerves, bone, and skin, because of its superior tunable chemical composition, topographical structures, and physiochemical properties. More importantly, inorganic biomaterials are easily combined with other organic materials, biological factors, and external stimuli to enhance their therapeutic effects. This review presents a comprehensive overview of recent advancements of inorganic biomaterials for innervated multi-tissue regeneration. It begins with introducing classification and properties of typical inorganic biomaterials and design rationale of inorganic-based material composites. Then, recent progresses of inorganic biomaterials in regenerating various nerves and nerve-innervated tissues with functional recovery are systematically reviewed. Finally, the existing challenges and future perspectives are proposed. This review may pave the way for the direction of inorganic biomaterials and offers a new strategy for tissue regeneration in combination of innervation.}, archive = {J_ADVS}, author = {Hongjian Zhang and Ziyi Zhao and Chengtie Wu}, doi = {10.1002/advs.202415344}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415344}, shortjournal = {Adv. Sci.}, title = {Bioactive inorganic materials for innervated multi-tissue regeneration}, volume = {12}, year = {2025}, }
• (2025). Anti-inflammatory macrophage-derived exosomes modified with self-antigen peptides for treatment of experimental autoimmune encephalomyelitis. ADVS, 12(13), 2415265. (www)

  @article{ , abstract = {Current treatments for autoimmune diseases often involve broad-acting immunosuppressants, which carry risks such as infections and malignancies. This study investigates whether exosomes derived from anti-inflammatory macrophages (AE) and decorated with myelin oligodendrocyte glycoprotein (MOG) peptide (AE/M) can induce immune tolerance in autoimmune diseases. Experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis, serves as the autoimmune disease model. Exosomes derived from myoblasts or fibroblasts are also modified with MOG peptides for comparison. Unlike their myoblast or fibroblast counterparts, exosomes from anti-inflammatory macrophages demonstrate a targeted capacity toward antigen-presenting cells. Moreover, AE/M uniquely promotes the differentiation of dendritic cells (DC) into a tolerogenic phenotype. When splenocytes are treated with AE/M, an increased population of tolerogenic DC (tolDC) is observed, even under proinflammatory stimuli. Subcutaneous administration of AE/M in the EAE mouse model results in MOG peptide-specific immune tolerance and preserves motor coordination. In contrast to treatments with fibroblast- or myoblast-derived exosomes modified with MOG peptides, AE/M treatment provides complete protection from EAE in mice. These findings highlight the potential of self-antigen modified AE as a versatile and adaptable nanoplatform for the treatment of various autoimmune diseases.}, archive = {J_ADVS}, author = {Qiaoyun Li and Jinwon Park and Jung Suk Kim and Quoc-Viet Le and Jaiwoo Lee and Yu-Kyoung Oh}, doi = {10.1002/advs.202415265}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415265}, shortjournal = {Adv. Sci.}, title = {Anti-inflammatory macrophage-derived exosomes modified with self-antigen peptides for treatment of experimental autoimmune encephalomyelitis}, volume = {12}, year = {2025}, }
• (2025). Cortical morphometric similarity remodeling in traumatic brain injury links cognitive impairments with transcriptional changes and type-specific cells. ADVS, 12(13), 2415262. (www)

  @article{ , abstract = {The heterogeneous injuries and resulting cognitive deficits pose significant challenges in the clinical management of mild traumatic brain injury (mTBI). However, the pathophysiological mechanisms related to heterogeneities of mTBI are still unclear. This study aims to explore the mechanisms underlying brain remodeling by examining the morphometric similarity (MS) alterations and corresponding transcriptomic signatures across adult and pediatric mTBI (adult mTBI: 112 acute patients, 47 follow-up chronic patients, 66 healthy controls [HCs]; pediatric mTBI: 30 acute patients, 31 HCs). A healthy adult cohort (N = 840) is included to derive the modularized brain MS networks representing interregional cortical connectivity. Subsequently, cortical MS remodeling patterns are identified involving mostly MS increases in the frontal modules with typical high MS and decreases in the occipital module with typical low MS, with more pronounced changes observed in the developing brain with mTBI. The abnormal MS changes are correlated with variable cognitive impairments. Moreover, cortical MS remodeling is also associated with the genes enriched in CA1 pyramidal cells and neuron-specific biological processes. The transcription-related cortical remodeling in mTBI might reveal the disruption of brain cellular architecture. Therapeutic modalities to intervene in specific cortex and tackle CA1 over-activation might better encircle the neurobiology of TBI.}, archive = {J_ADVS}, author = {Yizhen Pan and Zhuonan Wang and Xiang Zhang and Wenpu Zhao and Haonan Zhang and Xuan Li and Xiaoyan Jia and Qiuyu Ji and Bo Yin and Guanghui Bai and Tingting Wu and Zhiqi Lee and Jierui Ding and Lei Shi and Jie Zhang and David H. Salat and Lijun Bai}, doi = {10.1002/advs.202415262}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415262}, shortjournal = {Adv. Sci.}, title = {Cortical morphometric similarity remodeling in traumatic brain injury links cognitive impairments with transcriptional changes and type-specific cells}, volume = {12}, year = {2025}, }
• (2025). A novel tRF, HCETSR, derived from tRNA-Glu/TTC, inhibits HCC malignancy by regulating the SPBTN1-catenin complex axis. ADVS, 12(13), 2415229. (www)

  @article{ , abstract = {tRNA-derived fragments (tRFs), a novel class of small non-coding RNAs cleaved from transfer RNAs, have been implicated in tumor regulation. In this study, the role of a specific tRF, HCETSR is investigated, which is significantly downregulated in hepatocellular carcinoma (HCC) and correlates with advanced tumor burden and higher HCC mortality. Functional analyses revealed that HCETSR inhibits HCC malignancy and serves as an independent predictor of poor prognosis. Mechanistically, a novel SPTBN1/catenin complex axis regulated by HCETSR is identified. HCETSR binds to a critical domain of SPTBN1, disrupting its interaction with the catenin complex (comprising β-catenin, α-catenin, and P120-catenin), and facilitates the transfer of the catenin complex from the cell membrane to the nucleus. Specifically, HCETSR decreases the proteasomal degradation of β-catenin and inhibits the synthesis of nascent β-catenin. Furthermore, HCETSR suppresses the transcriptional activity of LEF1 through P120-catenin rather than α-catenin, thereby reducing β-catenin's influence on LEF1 activity. It is demonstrated that HCETSR is spliced from tRNA-Glu/TTC. The biogenesis of HCETSR and tRNA-Glu/TTC is regulated by the spliceosome and Dicer1. In conclusion, These findings suggest that HCETSR, derived from tRNA-Glu/TTC, inhibits HCC malignancy via modulation of the SPTBN1/catenin axis and may represent a promising prognostic marker and therapeutic strategy for HCC.}, archive = {J_ADVS}, author = {Tao Rui and Kangbei Zhu and Zonglei Mao and Jiaping Wu and Yi Pan and Qianwei Ye and Cong Chen and Aizhai Xiang and Jufeng Guo and Ning Tang and Jing Zhang and Shusen Zheng and Jian Liu and Xiao Xu}, doi = {10.1002/advs.202415229}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415229}, shortjournal = {Adv. Sci.}, title = {A novel tRF, HCETSR, derived from tRNA-Glu/TTC, inhibits HCC malignancy by regulating the SPBTN1-catenin complex axis}, volume = {12}, year = {2025}, }
• (2025). Nanodot-inspired precise bacterial gene suppression in a smart hydrogel bandage for underwater wound healing. ADVS, 12(13), 2415169. (www)

  @article{ , abstract = {The complex and dynamic nature of aquatic ecosystems, particularly in marine environments, makes managing wound infections a significant challenge for individuals engaged in underwater activities and for aquatic organisms. Although antibiotics have played a critical role in safeguarding humans and aquatic health, their risk of drug resistance and environmental impact present substantial obstacles to long-term sustainability. Using fin rot disease in turbot ( Scophthalmus maximus ) caused by infection of Vibrio anguillarum ( V. anguillarum ) as a model, a new strategy is presented that employs a carbon dot (CD)-based antisense oligonucleotide (ASO) delivery system, combined with an adhesive hydrogel, to achieve targeted gene silencing of V. anguillarum for underwater healing. The CDs that cause enhanced cytoplasmic membrane permeability, efficiently deliver ASOs into V. anguillarum without requiring additional equipment or chemical facilitators. The specific design of the ASO sequence enables targeted silencing of empA , achieving efficiency as high as 71.2%. An adhesive hydrogel is applied to boost the local concentration of ASO/CDs at wound sites in seawater, effectively sealing the infected area and preventing fin rot disease in turbot. This study pioneer targeted bacterial gene regulation using CD-based delivery integrated with a hydrogel bandage, offering practical solutions for managing underwater bacterial diseases.}, archive = {J_ADVS}, author = {Qingsong Zhang and Menghan Lu and Richang Ou and Hong Lin and Guanhua Xuan and Xiudan Wang and Xiaofeng Xu and Weiwei Zhang and Guoqing Wang}, doi = {10.1002/advs.202415169}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415169}, shortjournal = {Adv. Sci.}, title = {Nanodot-inspired precise bacterial gene suppression in a smart hydrogel bandage for underwater wound healing}, volume = {12}, year = {2025}, }
• (2025). Controlled self-assembly and photo-thermal activation of viologen-based 2D semiconductors for dual-function energy management in all-weather applications. ADVS, 12(13), 2415101. (www)

  @article{ , abstract = {Solar thermal technology offers a promising solution to water scarcity; however, the continuous operation of solar evaporators remains challenging due to sunlight's intermittent availability. Herein, an alternative strategy is proposed to achieve dual-functional energy management of photo-thermoactivated viologen T semiconductors for enhanced solar water evaporation, water-enabled electricity generation, and electrothermal evaporation. A sequential cyanide-bridged layer-directed intercalation approach is developed, where infinitely π-stacked, redox-active N-methyl bipyridinium cations with near-planar structures are sandwiched between cyanide-bridged Mn II –Fe III . The extended absorption range of 95% is achieved through radical–π interactions that occur within the continuously π-stacked N-methyl bipyridinium units upon thermal activation. The photo-thermoactivated Mn II –Fe III compounds anchored charcoal mask (Mn II –Fe III @CM) with a sided evaporation structure and controllable water transfer, offering a high evaporation rate of 2.39 kg m −2 h −1 under one sun (1 kW m −2 ) illumination. As an energy nanogenerator, the output voltage and current of Mn II –Fe III @CM can reach up to ≈480 mV and ≈60 µA cm −2 under ambient conditions. Furthermore, storage of electrical energy from Mn II –Fe III @CM using energy storage devices is expected to enable all-weather evaporation by electric heating due to unsustainable sunlight, providing a unique technology for seawater desalination and offshore work platform energy access.}, archive = {J_ADVS}, author = {Muhammad Sultan Irshad and Iftikhar Ahmed and Naila Arshad and Muneerah Alomar and Yue Shu and Guo Zhenzhen and Shafiq Ahmad and Ioannis Zuburtikudis and Shi Ruiqing and Tao Mei and Fan Xiaochao and Nang Xuan Ho and Thuy-Duong Pham and Van-Duong Dao and Rong Li and Xianbao Wang}, doi = {10.1002/advs.202415101}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2415101}, shortjournal = {Adv. Sci.}, title = {Controlled self-assembly and photo-thermal activation of viologen-based 2D semiconductors for dual-function energy management in all-weather applications}, volume = {12}, year = {2025}, }
• (2025). Patient-derived bladder cancer organoids as a valuable tool for understanding tumor biology and developing personalized treatment. ADVS, 12(13), 2414558. (www)

  @article{ , abstract = {Bladder cancer (BC) is a heterogeneous disease with high recurrence rates and variable treatment responses. To address these clinical challenges, the world's first bladder cancer patient-derived organoids (PDOs) biobank is established based on an Asian population. Thirty-six BC-PDOs are generated from 56 patients and demonstrated that the BC-PDOs can replicate the histological and genomic features of parental tumors. Drug screening tests are conducted with a broad spectrum of conventional chemotherapeutic and targeted therapy drugs and identified differential drug sensitivities among the BC-PDOs. These in vitro results are consistently supported by the PDO xenograft animal studies and patients’ clinical treatment outcomes, thereby verifying the predictive power of PDOs for drug responses in BC patients. By analyzing the genetic profiles of the PDOs, specific driver genes that correlate with drug sensitivity to two stand-of-care chemotherapeutics, cisplatin, and gemcitabine, are identified. Additionally, the practicality of PDOs in investigating the tumor microenvironment has been demonstrated. This study underscores the utility of PDOs in advancing the understanding of bladder cancer and the development of personalized therapeutic strategies. The BC-PDOs biobank provides an ideal preclinical platform for supporting the development of personalized treatment strategies for BC patients. This study also provides insights into the potential mechanisms of drug resistance, paves the way for subsequent region-specific research, and demonstrates the possibility of using PDO-related models to direct future research in developing drugs targeting tumor microenvironments.}, archive = {J_ADVS}, author = {Hongda Zhao and Na Lin and Vincy Wing Sze Ho and Kang Liu and Xuan Chen and Hongwei Wu and Peter Ka-Fung Chiu and Linda Huang and Zahra Dantes and Ka-Leung Wong and Ho-Fai Chau and Ivan Ching-Ho Ko and Chris Ho-Ming Wong and David Ka-Wai Leung and Steffi Kar-Kei Yuen and Dinglan Wu and Xiaofan Ding and Chi Fai Ng and Jeremy Yuen-Chun Teoh}, doi = {10.1002/advs.202414558}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2414558}, shortjournal = {Adv. Sci.}, title = {Patient-derived bladder cancer organoids as a valuable tool for understanding tumor biology and developing personalized treatment}, volume = {12}, year = {2025}, }
• (2025). Maladaptive peripheral ketogenesis in schwann cells mediated by CB1R contributes to diabetic neuropathy. ADVS, 12(13), 2414547. (www)

  @article{ , abstract = {Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. Although studies have previously investigated metabolic disruptions in the peripheral nervous system (PNS), the exact metabolic mechanisms underlying DPN remain largely unknown. Herein, a specific form of metabolic remodeling involving aberrant ketogenesis within Schwann cells (SCs) in streptozotocin (STZ)-induced type I diabetes mellitus is identified. The PNS adapts poorly to such aberrant ketogenesis, resulting in disrupted energy metabolism, mitochondrial damage, and homeostatic decompensation, ultimately contributing to DPN. Additionally, the maladaptive peripheral ketogenesis is highly dependent on the cannabinoid type-1 receptor (CB 1 R)-Hmgcs2 axis. Silencing CB 1 R reprogrammed the metabolism of SCs by blocking maladaptive ketogenesis, resulting in rebalanced energy metabolism, reduced histopathological changes, and improved neuropathic symptoms. Moreover, this metabolic reprogramming can be induced pharmacologically using JD5037, a peripheral CB 1 R blocker. These findings revealed a new metabolic mechanism underlying DPN, and promoted CB 1 R as a promising therapeutic target for DPN.}, archive = {J_ADVS}, author = {Weizhen Li and Tuo Yang and Ningning Wang and Baolong Li and Chuikai Meng and Kaiming Yu and Xiongyao Zhou and Rangjuan Cao and Shusen Cui}, doi = {10.1002/advs.202414547}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2414547}, shortjournal = {Adv. Sci.}, title = {Maladaptive peripheral ketogenesis in schwann cells mediated by CB1R contributes to diabetic neuropathy}, volume = {12}, year = {2025}, }
• (2025). Rejuvenating hyaline cartilage with senescence-targeting si-ADAM19 delivery for osteoarthritis therapy. ADVS, 12(13), 2414419. (www)

  @article{ , abstract = {Osteoarthritis (OA) is one of the most common joint degenerative diseases without effective treatment, whose pathology is related to the local accumulation of senescent cells (SnCs). However, existing SnCs-scavenging drugs “senolytics” may lead to the exhaustion of stem and progenitor cells, impairing chondrocyte proliferation and cartilage regeneration. Here, ADAM19, a kind of endopeptidases from the ADAM (a disintegrin and metalloproteinase) family, is identified as a novel target for senescent chondrocyte rejuvenation. ADAM19 is elevated in senescent chondrocytes in both mice and human osteoarthritic joints, as well as in cellular senescence model in vitro. ADAM19 knockdown not only significantly attenuated senescent phenotype of chondrocytes, but also promoted cell proliferation and extracellular matrix synthesis. RNA sequencing revealed ADAM19 may regulate chondrocyte senescence mainly through the PI3K/AKT signal axis. In addition, a senescence-targeting small interfering RNA (siRNA) delivery system is developed for in vivo delivery of therapeutic siRNA. The complex selectively released ADAM19 siRNA in SnCs and performed high silencing effect on target gene. Furthermore, intra-articular (IA) injection of the complex once every two weeks in OA mice effectively reduced SnCs accumulation and promoted hyaline cartilage regeneration. This study provides a promising strategy for the development of regenerative RNA interference therapy.}, archive = {J_ADVS}, author = {Jiasheng Wang and Peng Guo and Dongmei Wu and Junzhi Yi and Qi Jiang and Jiajie Hu and Hongwei Ouyang}, doi = {10.1002/advs.202414419}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2414419}, shortjournal = {Adv. Sci.}, title = {Rejuvenating hyaline cartilage with senescence-targeting si-ADAM19 delivery for osteoarthritis therapy}, volume = {12}, year = {2025}, }
• (2025). Full recovery of polyimide wastes into high-value products through break and reconstruction of imide ring. ADVS, 12(13), 2414416. (www)

  @article{ , abstract = {Polyimide (PI) is a promising engineering plastic but difficult to recycle due to its aromatic heterocyclic structures, especially for thermosetting PI. Herein, an ingenious cascade pathway for high-value and full recovery of thermosetting PI under mild conditions is presented. Specifically, the imide ring is first broken through aminolysis to degrade PI and is reconstructed under following hydrolysis to achieve excellent thermal stability in subsequent products. When recycling thermoplastic PI, the yield of 91% and 82% appears in diamines and polyhydroxylated compounds, respectively. As focusing on the recovery of thermosetting PI, aside from the efficient recovery of diamines, the crosslinked component is converted into hyperbranched flame retardant carbonizers for preparing copolyester, and it correspondingly achieves good flame retardant effect with an addition of merely 4 wt.%. The success of this work capitalizes on the unique structure and properties of the raw material, stimulating innovative pathways in the field of thermoset waste recovery and new material design.}, archive = {J_ADVS}, author = {Haodi Chen and Xuehui Liu and Shouqin Zhang and Shimei Xu and Teng Fu and Yu-Zhong Wang}, doi = {10.1002/advs.202414416}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2414416}, shortjournal = {Adv. Sci.}, title = {Full recovery of polyimide wastes into high-value products through break and reconstruction of imide ring}, volume = {12}, year = {2025}, }
• (2025). HBimmCue: A versatile fluorescent probe for multi-scale imaging of lipid polarity and membrane order in inner mitochondrial membrane. ADVS, 12(13), 2414343. (www)

  @article{ , abstract = {Mitochondrial membrane environmental dynamics are crucial for understanding function, yet high-resolution observation remains challenging. Here, HBimmCue is introduced as a fluorescent probe localized to inner mitochondrial membrane (IMM) that reports lipid polarity and membrane order changes, which correlate with cellular respiration levels. Using HBimmCue and fluorescence lifetime imaging microscopy (FLIM), IMM lipid heterogeneity is uncovered across scales, from nanoscale structures within individual mitochondria to mouse pre-implantation embryos. At the sub-organelle level, stimulated emission depletion (STED)-FLIM imaging highlights nanoscale polarity variations within the IMM. At the sub-cellular and cellular level, reduced IMM lipid polarity is observed in damaged mitochondria marked for lysosomal degradation and distinct IMM lipid distributions are identified in neurons and disease models. Additionally, metabolic dysfunction associated with oocytes aging and metabolic reprogramming from zygote to blastocyst is detected. Together, the work demonstrates the broad applicability of HBimmCue, offering a new paradigm for investigating lipid polarity and respiration level at multiple scales.}, archive = {J_ADVS}, author = {Shu Gao and Jing Sun and Yiwei Hou and Xichuan Ge and Ming Shi and Hongxi Zheng and Yan Zhang and Meiqi Li and Baoxiang Gao and Peng Xi}, doi = {10.1002/advs.202414343}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2414343}, shortjournal = {Adv. Sci.}, title = {HBimmCue: A versatile fluorescent probe for multi-scale imaging of lipid polarity and membrane order in inner mitochondrial membrane}, volume = {12}, year = {2025}, }
• (2025). GhLPF1 associated network is involved with cotton lint percentage regulation revealed by the integrative analysis of spatial transcriptome. ADVS, 12(13), 2414175. (www)

  @article{ , abstract = {Cotton fibers, derived from the epidermis of the ovule, provide a sustainable natural fiber source for the textile industry. Traits related to fiber yield are predominantly determined by molecular regulations in the epidermis of the outer integument (OI) region of the cotton ovule. Here, we identify an R2R3 MYB transcription factor coding gene GhLPF1 within the QTL-LP-ChrA06 locus for lint percentage (LP, percentage of lint to seed cotton) through constructing the 1-Day Post Anthesis Cotton Ovule Spatial Transcriptome Atlas. GhLPF1 is subjected as a downstream target of miR828 during fiber development. The direct downstream genes (DDGs) of GhLPF1 are biased to increased expression in GhLPF1-CR , and are preferentially expressed in OI, so that GhLPF1 is primarily a transcriptional repressor to its DDGs. Population-wide transcriptome analysis confirms that expression variation of GhLPF1-DDGs is significantly biased to negative correlation with LP, among which a type I homeobox protein-coding gene GhHB6 is further validated to be the directly downstream gene of GhLPF1. Given these data, it is demonstrated that GhLPF1 mediates a regulation network in LP as a transcriptional repressor, which makes it a valuable functional marker for fiber-trait improvement application from QTL-LP-ChrA06.}, archive = {J_ADVS}, author = {Hongyu Wu and Luyao Wang and Shengjun Zhao and Mengtao Gao and Junfeng Cao and Yupeng Hao and Li Yu and Ting Zhao and Siyuan Wang and Jin Han and Yumeng Zhu and Yongyan Zhao and Jie Li and Ke Nie and Kening Lu and Linyun Ding and Zhiyuan Zhang and Tianzhen Zhang and Xueying Guan}, doi = {10.1002/advs.202414175}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2414175}, shortjournal = {Adv. Sci.}, title = {GhLPF1 associated network is involved with cotton lint percentage regulation revealed by the integrative analysis of spatial transcriptome}, volume = {12}, year = {2025}, }
• (2025). TRIM56 promotes white adipose tissue browning to attenuate obesity by degrading TLE3. ADVS, 12(13), 2414073. (www)

  @article{ , abstract = {In mammals, the activation of thermogenic adipocytes, such as beige and brown adipocytes, can significantly increase overall energy expenditure, offering a promising strategy to combat metabolic diseases. Despite its considerable potential, the regulatory mechanisms governing this activation remain largely elusive. This study bridges this gap by elucidating that tripartite motif 56 (TRIM56), an E3 ubiquitin ligase, is upregulated in response to cold stimuli, thereby promoting the recruitment of beige adipocytes. Notably, the overexpression of TRIM56 in adipocytes is shown to help mice maintain a core temperature under cold conditions, as well as confer protection against diet-induced obesity. Mechanistically, TRIM56 facilitates the degradation of the transducin-like enhancer protein 3 (TLE3) protein by promoting its K48-linked ubiquitination, which subsequently triggers the activation of thermogenic genes in subcutaneousl white adipose tissue and improved the metabolic profiles. These findings unveil a novel function for TRIM56 in adipocyte browning, suggesting its potential as a therapeutic target for the treatment of metabolic disorders.}, archive = {J_ADVS}, author = {Haojie Qin and Yi Zhong and Jinhui Huang and Yanli Miao and Meng Du and Kai Huang}, doi = {10.1002/advs.202414073}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2414073}, shortjournal = {Adv. Sci.}, title = {TRIM56 promotes white adipose tissue browning to attenuate obesity by degrading TLE3}, volume = {12}, year = {2025}, }
• (2025). N6-methyladenosine-modified circSMAD4 prevents lumbar instability induced cartilage endplate ossification. ADVS, 12(13), 2413970. (www)

  @article{ , abstract = {Lumbar instability causes cartilage endplate ossification and intervertebral disc degeneration. In this study, it is determined that circSMAD4, a Yap1-related circRNA, is stably downregulated under abnormal stress. In vitro, circSMAD4 knockdown resulted in Yap1 mRNA degradation, whereas circSMAD4 overexpression increased Yap1 mRNA expression and nuclear translocation. Hence, the stabilization of circSMAD4 is essential for maintaining the homeostasis of endplate cartilage under abnormal stress. Furthermore, transcriptome sequencing and mass spectrometry analysis revealed that METTL14-mediated N 6 -methyladenosine (m 6 A) modification can stabilize circSMAD4 expression. Moreover, circSMAD4 is shown to regulate Yap1 mRNA through the m6A reader IGF2BP1. The IGF2BP1 functions to translocate Yap1 mRNA into the nucleus, which protects endplate chondrocytes from degeneration. Finally, local injection of an AAV5-containing circSMAD4 overexpression plasmid successfully rescued LSI-induced cartilage endplate degeneration, which wasn't observed in Yap1 knockout mice. These findings suggest that m6A-modified circSMAD4 can stabilize Yap1 mRNA expression and translocation, thus preventing degeneration of the cartilage endplate under abnormal stress. Hence, circSMAD4 may become a potential therapeutic tool for managing instability-induced intervertebral disc degeneration.}, archive = {J_ADVS}, author = {Hanwen Li and Yingchuang Tang and Sihan Hu and Xingbang Ruan and Junxin Zhang and Yihan Shi and Liang Qiu and Huilin Yang and Kai Zhang and Hao Chen and Kangwu Chen}, doi = {10.1002/advs.202413970}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413970}, shortjournal = {Adv. Sci.}, title = {N6-methyladenosine-modified circSMAD4 prevents lumbar instability induced cartilage endplate ossification}, volume = {12}, year = {2025}, }
• (2025). Nanomedicine penetrating blood-pancreas barrier for effective treatment of acute pancreatitis. ADVS, 12(13), 2413925. (www)

  @article{ , abstract = {Acute pancreatitis (AP) is a primary contributor to hospitalization and in-hospital mortality worldwide. Targeted elimination of mitochondrial reactive oxygen species (mtROS) within pancreatic acinar cells (PACs) represents an ideal strategy for treating AP. However, existing drugs fail to overcome the physiological barriers of the pancreas to effectively reach PACs mitochondria due to the trade-off between conventional positively charged mitochondrial-targeting groups and their inability to penetrate the blood-pancreas barrier (BPB). Here, a tungsten-based heteropolyacid nano-antioxidant (mTWNDs) is introduced, co-modified with tannic acid (TA) and melanin, enabling site-specific clearance of mtROS in PACs, offering a highly effective treatment for AP. TA exhibits a strong affinity for proline-rich type III collagen and the mitochondrial outer membrane protein TOM20. This unique property allows mTWNDs to traverse the damaged BPB-exposing type III collagen to reach PACs and subsequently penetrate mitochondria for targeted mtROS elimination. In cerulein-induced AP mice, mTWNDs reversed AP at 1/50th the dose of N-acetylcysteine, suppressing PACs apoptosis and inflammation by blocking the stimulator of the interferon genes pathway activation in macrophage. This study establishes a mitochondrial-targeting antioxidant nanomedicine strategy for AP treatment.}, archive = {J_ADVS}, author = {Dan Wang and Shuya Wang and Jinjin Liu and Xiaojing Shi and Tingli Xiong and Ruishi Li and Wei Wei and Liandong Ji and Qiong Huang and Xuejun Gong and Kelong Ai}, doi = {10.1002/advs.202413925}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413925}, shortjournal = {Adv. Sci.}, title = {Nanomedicine penetrating blood-pancreas barrier for effective treatment of acute pancreatitis}, volume = {12}, year = {2025}, }
• (2025). Tracking active site formation during oxidative activation of copper-exchanged zeolites for methane-to-methanol conversion. ADVS, 12(13), 2413870. (www)

  @article{ , abstract = {The evolution of active sites in Cu-zeolites for the CH 4 -to-CH 3 OH conversion has been investigated during oxidative treatment in O 2 . Three samples with different frameworks but comparable Cu loadings and Si/Al ratios have been prepared to assess the influence of topology on material oxidizability and the nature of the generated Cu(II) species. Complementary spectroscopic studies highlight that isomeric Cu(II) centers hosted within different topologies are characterized by distinct formation rates. In turn, the framework-specific kinetics of Cu(II) site generation regulate the overall oxidation potential of the individual zeolites. Apart from the topology, the formation rate of different Cu(II) species is governed by their specific structure, with dimeric Cu(II) centers ([Cu 2 (µ-O)] 2+ ) being generated faster than monomeric ([CuOH] + , Cu 2+ ) ones. Elevated temperatures accelerate the evolution of Cu(II) monomers but cause [Cu 2 (µ-O)] 2+ to undergo autoreduction. The reversibility of this process is framework-dependent. Consequently, even though two types of [Cu 2 (µ-O)] 2+ form at low temperatures in each material, only specific ones remain after high-temperature treatment. The autoreduction of [Cu 2 (µ-O)] 2+ is accompanied by its transient reduction by hydrocarbon residues, originating from the preceding treatment in CH 4 . The oxidative decomposition of these impurities yields H 2 O, which adsorbs on [Cu 2 (µ-O)] 2+ masks their spectroscopic fingerprints, and renders them inactive.}, archive = {J_ADVS}, author = {Andreas Brenig and Jörg W. A. Fischer and Daniel Klose and Gunnar Jeschke and Jeroen A. van Bokhoven and Vitaly L. Sushkevich}, doi = {10.1002/advs.202413870}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413870}, shortjournal = {Adv. Sci.}, title = {Tracking active site formation during oxidative activation of copper-exchanged zeolites for methane-to-methanol conversion}, volume = {12}, year = {2025}, }
• (2025). N-heterocyclic carbene organocatalysis enabled modular synthesis of fluorinated isoflavonoids to suppress proliferation and migration in breast cancer cells. ADVS, 12(13), 2413851. (www)

  @article{ , abstract = {Isoflavonoids represent a privileged scaffold among various bioactive natural products, rendering their structural diversification through green synthesis and subsequent biological evaluations a compelling research area. In this study, an NHC organocatalytic radical acylalkylation of 1,3-enynes using salicylaldehydes is presented, followed by a cascade intramolecular annulation, yielding a series of fluorinated isoflavone derivatives with substantial yields under environmental-friendly conditions. This approach, distinguished by its excellent modularity and high functional group tolerance, represents an unprecedented organocatalytic 1,3,4-trifunctionalization of 1,3-enynes designed for the green synthesis of bioactive isoflavones in a single step. Furthermore, it is demonstrated that these synthesized fluorinated isoflavonoids effectively suppress proliferation in breast cancer cells, with the most potent compound 8 also inhibiting migration in MDA-MB-231 cells.}, archive = {J_ADVS}, author = {Yan-Qing Liu and Lei-Lei Fu and Long-Hai Hong and Xin-Xin Kou and Xiang Zhang and Rong Zeng and Yong-Qi Zhen and Bo Han and Jun-Long Li}, doi = {10.1002/advs.202413851}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413851}, shortjournal = {Adv. Sci.}, title = {N-heterocyclic carbene organocatalysis enabled modular synthesis of fluorinated isoflavonoids to suppress proliferation and migration in breast cancer cells}, volume = {12}, year = {2025}, }
• (2025). One-pot construction of NHS-activated magnetic particles for chemoselective capture of carboxyl metabolites. ADVS, 12(13), 2413830. (www)

  @article{ , abstract = {Chemoselective probes immobilize on magnetic materials show great promise in simplifying sample handling and enhancing detection sensitivity. However, their complicated preparation and associated expense limit broader application. In this study, novel magnetic particles with abundant N-hydroxysuccinimide (NHS) esters on the surface are conveniently synthesized using a one-pot method without carbodiimide activation carboxylate molecules. Subsequently, multifunctional probes are synthesized by immobilizing high-density chemical probes on the surface of the magnetic materials through a postsynthetic modification strategy. This versatile probe facilitates the rapid capture of carboxylated compounds from complex matrices, with the labeled metabolites release from the magnetic materials subsequently analyzed using ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS). The advantages of this innovative chemical biological tool include the simplicity and low cost of the synthesis, as well as the capability to analyze polar and volatile carboxylated metabolites via LC-MS. This new strategy is successfully applied to analyze short-chain fatty acids (SCFAs) in rat cecal contents, demonstrating the reliability of the analytical method. This study presents a cost-effective and easy-to-implement approach for preparing NHS-activated magnetic particles and offers a versatile probe with chemoselective extraction and labeling capabilities, providing a practical tool for analyzing SCFAs in the gut.}, archive = {J_ADVS}, author = {Shuai Liu and Meng Yu and Xin-Yao Luo and Jie Liu and Zhong-Mei Zou}, doi = {10.1002/advs.202413830}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413830}, shortjournal = {Adv. Sci.}, title = {One-pot construction of NHS-activated magnetic particles for chemoselective capture of carboxyl metabolites}, volume = {12}, year = {2025}, }
• (2025). High-impulse, modular, 3D-printed CubeSat electrospray thrusters throttleable via pressure and voltage control. ADVS, 12(13), 2413706. (www)

  @article{ , abstract = {This study reports the proof-of-concept demonstration of novel, additively manufactured, droplet-emitting electrospray emitter arrays for CubeSat thruster applications. The modular thruster design incorporates multiscale features by employing two different vat photopolymerization technologies, i.e., digital light processing for defining mesoscale features, and two-photon polymerization for creating microscale features. The thruster design includes optimized, 50 µm-diameter microfluidic channels to attain uniform emitter array operation. Devices with up to 8 modules of 4 emitters were tested in a vacuum to assess their performance. Stable and uniform electrospray emission was achieved across all emitters, with a near 100% transmission across the extractor. Both pressure (flow rate) and voltage modulation are investigated as methods for controlling the emitted current and, by extension, the thrust generated by the devices. The per-emitter current followed a well-known square root relationship with flow rate; in addition, a linear relationship between per-emitter current and extractor voltage is observed. Compared to pressure control, modulating thrust via voltage control simplifies system design, eliminating the need for complex valves and enabling a wider throttle range. Estimated thrust and specific impulse are comparable to, or better than reported droplet-emitting electrospray thrusters. These findings demonstrate the potential of additive manufacturing to implement electrospray propulsion hardware.}, archive = {J_ADVS}, author = {Hyeonseok Kim and Luis Fernando Velásquez-García}, doi = {10.1002/advs.202413706}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413706}, shortjournal = {Adv. Sci.}, title = {High-impulse, modular, 3D-printed CubeSat electrospray thrusters throttleable via pressure and voltage control}, volume = {12}, year = {2025}, }
• (2025). Tribbles pseudokinase 3 converts sorafenib therapy to neutrophil-mediated lung metastasis in hepatocellular carcinoma. ADVS, 12(13), 2413682. (www)

  @article{ , abstract = {Rapid development of resistance to sorafenib and subsequent hyperprogression in patients with advanced hepatocellular carcinoma (HCC) pose significant challenges, with the underlying mechanisms still largely unknown. Herein, sorafenib-induced TRIB3 is identified as a liver-specific determinant driving secondary resistance to sorafenib by facilitating the accumulation of protumorigenic neutrophils within tumors. Mechanistically, TRIB3, triggered by the sorafenib-elicited ROS-ER stress axis, operates in an NF-κB-dependent manner to upregulate CXCR1/2 ligands, subsequently promoting neutrophil recruitment into tumors. These enriched neutrophils enhance epithelial-mesenchymal transition processes in malignant cells through the oncostatin M-STAT3 pathway, thereby repurposing the therapeutic efficacy of sorafenib away from anti-angiogenesis and toward lung metastasis. Clinically, elevated TRIB3 expression indicates inferior survival and unfavorable clinical efficacy of sorafenib in HCC patients. Correspondingly, strategies that either inhibiting TRIB3 upregulation or blocking its downstream signaling successfully augment the therapeutic efficacy of sorafenib and prevent sorafenib-induced hyperprogression in vivo. The study thus identifies a pivotal mechanism of sorafenib resistance in HCC, centered on the TRIB3-mediated recruitment of protumorigenic neutrophils and subsequent disease hyperprogression.}, archive = {J_ADVS}, author = {Xu-Yan Wang and Yuan Liao and Rui-Qi Wang and Yi-Tong Lu and Ying-Zhe Wang and Yu-Qi Xin and Dong-Ming Kuang and Xiang-Ming Lao and Junying Xu and Zhi-Ling Zhou and Kunhua Hu}, doi = {10.1002/advs.202413682}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413682}, shortjournal = {Adv. Sci.}, title = {Tribbles pseudokinase 3 converts sorafenib therapy to neutrophil-mediated lung metastasis in hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Elevated GFI1 in alveolar macrophages suppresses ACOD1 expression and exacerbates lipopolysaccharide-induced lung injury in obesity. ADVS, 12(13), 2413546. (www)

  @article{ , abstract = {To investigate the mechanisms behind the worsening of acute lung injury (ALI) in obesity, transcriptomic sequencing is performed, and significantly reduced mRNA levels of Aconitate Decarboxylase 1 (ACOD1) in the lung tissue of high-fat diet (HFD) mice are found. Clinical samples are collected, an ALI model is established in HFD mice, and both human and mouse samples are analyzed, revealing a significant decrease in ACOD1 expression in lung tissue and alveolar macrophages in obesity. Further in vivo and in vitro experiments show that ACOD1 knockdown worsens lung injury, inflammation, and oxidative stress, while ACOD1 overexpression alleviates these effects. Moreover, nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition diminishes the protective effects of ACOD1 overexpression in ALI exacerbated by obesity. Additionally, in the context of obesity, growth factor independent 1 (GFI1) protein levels are elevated in alveolar macrophages, and its knockdown leads to upregulated ACOD1 expression. Therefore, this study suggests that ACOD1 downregulation in alveolar macrophages is a key factor in worsening ALI in obesity, likely driven by GFI1 upregulation.}, archive = {J_ADVS}, author = {Jingyue Ma and Yichan Ao and Zhen Yue and Zhiqiao Wang and Xiangyu Hou and Hongbin Li and Hanbing Wang and Siqing Luo and Jianyu He and Zikun Duan and Ling Liu and Ke Wei}, doi = {10.1002/advs.202413546}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413546}, shortjournal = {Adv. Sci.}, title = {Elevated GFI1 in alveolar macrophages suppresses ACOD1 expression and exacerbates lipopolysaccharide-induced lung injury in obesity}, volume = {12}, year = {2025}, }
• (2025). Ternary schottky junction for sonocatalytic water splitting in gas-immunotherapy-mediated cancer treatment. ADVS, 12(13), 2413519. (www)

  @article{ , abstract = {Hydrogen therapy has shown new potential in cancer treatment, particularly in high-pressure and hypoxic areas, where it demonstrates the ability to alter the tumor microenvironment and regulate tumor metabolism. Hydrogen disrupts the mitochondrial function of cancer cells, interferes with their energy metabolism, and ultimately leads to energy depletion and apoptosis. In this study, a sonocatalyst (BPM), is designed to generate hydrogen and oxygen in situ within tumors, further enhancing the therapeutic efficacy. The mesocrystalline structure of BPM, composed of bismuth fluoride, polyoxometalates, and molybdenum carbide, significantly improves charge separation and electron transfer efficiency under ultrasound irradiation, resulting in an efficient water-splitting reaction. By simultaneously generating hydrogen and oxygen within the tumor microenvironment and depleting glutathione, BPM effectively triggers oxidative stress and alleviates hypoxia, thereby disrupting mitochondrial function and inhibiting energy metabolism in cancer cells. Additionally, BPM enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, and polarizing macrophages toward the M1 phenotype, reversing the immunosuppressive state of the tumor microenvironment. The results indicate that BPM holds potential for gas-immunotherapy combination treatments, offering a multifunctional strategy to improve cancer therapy outcomes.}, archive = {J_ADVS}, author = {Rui Zhang and Qian Wang and Junjie Pan and Jun Du and Han Yang and Bingfeng Wang and Yuhao Li and Yuqing Miao and Xumin Hou and Jingxiang Wu and Qing Miao}, doi = {10.1002/advs.202413519}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413519}, shortjournal = {Adv. Sci.}, title = {Ternary schottky junction for sonocatalytic water splitting in gas-immunotherapy-mediated cancer treatment}, volume = {12}, year = {2025}, }
• (2025). Customization of ethylene glycol (EG)-induced BmoR-based biosensor for the directed evolution of PET degrading enzymes. ADVS, 12(13), 2413205. (www)

  @article{ , abstract = {The immense volume of plastic waste poses continuous threats to the ecosystem and human health. Despite substantial efforts to enhance the catalytic activity, robustness, expression, and tolerance of plastic-degrading enzymes, the lack of high-throughput screening (HTS) tools hinders efficient enzyme engineering for industrial applications. Herein, we develop a novel fluorescence-based HTS tool for evolving polyethylene terephthalate (PET) degrading enzymes by constructing an engineered BmoR-based biosensor targeting the PET breakdown product, ethylene glycol (EG). The EG-responsive biosensors, with notably enhanced dynamic range and operation range, are customized by fluorescence-activated cell sorting (FACS)-assisted transcription factor engineering. The ingeniously designed SUMO-MHETase-FastPETase (SMF) chimera successfully addresses the functional soluble expression of MHETase in Escherichia coli and mitigates the inhibitory effect of mono-(2-hydroxyethyl) terephthalic acid (MHET) intermediate commonly observed with PETase alone. The obtained SM M3 F mutant demonstrates 1.59-fold higher terephthalic acid (TPA) production, with a 1.18-fold decrease in K m , a 1.29-fold increase in V max , and a 1.52-fold increase in k cat / K m , indicating stronger affinity and catalytic activity toward MHET. Furthermore, the SM M3 F crude extract depolymerizes 5 g L −1 bis-(2-hydroxyethyl) terephthalic acid (BHET) into TPA completely at 37 °C within 10 h, which is then directedly converted into value-added protocatechuic acid (PCA) (997.16 mg L −1 ) and gallic acid (GA) (411.69 mg L −1 ) at 30 °C, establishing an eco-friendly ‘PET-BHET-MHET-TPA-PCA-GA’ upcycling route. This study provides a valuable HTS tool for screening large-scale PET and MHET hydrolases candidates or metagenomic libraries, and propels the complete biodegradation and upcycling of PET waste.}, archive = {J_ADVS}, author = {Min Li and Zhenya Chen and Wuyuan Zhang and Tong Wu and Qingsheng Qi and Yi-Xin Huo}, doi = {10.1002/advs.202413205}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413205}, shortjournal = {Adv. Sci.}, title = {Customization of ethylene glycol (EG)-induced BmoR-based biosensor for the directed evolution of PET degrading enzymes}, volume = {12}, year = {2025}, }
• (2025). Advances in fecal microbiota transplantation for gut dysbiosis-related diseases. ADVS, 12(13), 2413197. (www)

  @article{ , abstract = {This article provides an overview of the advancements in the application of fecal microbiota transplantation (FMT) in treating diseases related to intestinal dysbiosis. FMT involves the transfer of healthy donor fecal microbiota into the patient's body, aiming to restore the balance of intestinal microbiota and thereby treat a variety of intestinal diseases such as recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), constipation, short bowel syndrome (SBS), and irritable bowel syndrome (IBS). While FMT has shown high efficacy in the treatment of rCDI, further research is needed for its application in other chronic conditions. This article elaborates on the application of FMT in intestinal diseases and the mechanisms of intestinal dysbiosis, as well as discusses key factors influencing the effectiveness of FMT, including donor selection, recipient characteristics, treatment protocols, and methods for assessing microbiota. Additionally, it emphasizes the key to successful FMT. Future research should focus on optimizing the FMT process to ensure long-term safety and explore the potential application of FMT in a broader range of medical conditions.}, archive = {J_ADVS}, author = {Shuna Hou and Jiachen Yu and Yongshuang Li and Duoyi Zhao and Zhiyu Zhang}, doi = {10.1002/advs.202413197}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413197}, shortjournal = {Adv. Sci.}, title = {Advances in fecal microbiota transplantation for gut dysbiosis-related diseases}, volume = {12}, year = {2025}, }
• (2025). Integration of circulating tumor DNA and metabolic parameters on 18F-fludeoxyglucose positron emission tomography for outcome prediction in unresectable locally advanced non-small cell lung cancer. ADVS, 12(13), 2413125. (www)

  @article{ , abstract = {This prospective study explores the prognostic value of circulating tumor DNA (ctDNA) and positron emission tomography/computed tomograpy (PET/CT) in unresectable locally advanced non-small cell lung cancer (LA-NSCLC) treated with definitive chemoradiotherapy (CRT). The discovery set includes 62 patients, with 62 baseline and 53 post-CRT plasma samples. PET/CT is performed at baseline, and 33 patients undergo mid-treatment scans after 40 Gy. Baseline ctDNA is detected in 71.0% of patients. Pre-treatment ctDNA concentration correlates with total metabolic tumor volume (TMTV) ( p < 0.001) and total lesion glycolysis (TLG) ( p = 0.001) but not treatment response or survival. However, patients with undetectable ctDNA and low TMTV show significantly longer progression-free survival (PFS) (34.2 vs 10.1 months, p = 0.027). Post-CRT, ctDNA is detected in 47.2% of patients, while ctDNA concentration ( p = 0.005) and variant allele frequency (VAF) ( p = 0.005) significantly decline. Undetectable post-CRT ctDNA associates with longer PFS ( p < 0.001) and overall survival (OS) ( p = 0.001). Higher ∆TMTV correlates with improved PFS and OS. Similar findings were obtained in a test of 19 patients. These results highlight post-CRT ctDNA and ∆TMTV as robust prognostic markers, potentially identifying patients who may forgo ICI consolidation.}, archive = {J_ADVS}, author = {Leilei Wu and Zhenshan Zhang and Chenxue Jiang and Li Li and Xiaojiang Sun and Menglin Bai and Ming Liu and Kangli Xiong and Jinbiao Shang and Jinming Yu and Shuanghu Yuan and Yang Yang and Yaping Xu}, doi = {10.1002/advs.202413125}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413125}, shortjournal = {Adv. Sci.}, title = {Integration of circulating tumor DNA and metabolic parameters on 18F-fludeoxyglucose positron emission tomography for outcome prediction in unresectable locally advanced non-small cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). A serum resistant polymer with exceptional endosomal escape and mRNA delivery efficacy for CRISPR gene therapy. ADVS, 12(13), 2413006. (www)

  @article{ , abstract = {Nanoparticle-based mRNA delivery offers a versatile platform for innovative therapies. However, most of the current delivery systems are limited by poor serum tolerance, suboptimal endosomal escape and mRNA delivery efficacy. Herein, a highly efficient mRNA-delivering material is identified from a library of fluoropolymers. The lead material FD17 shows exceptional serum stability and endosomal escape, enabling efficient mRNA delivery into various cell types, surpassing commercial mRNA delivery reagents such as Lipofectamine 3000. The formed mRNA nanoparticles adsorb abundant serum albumin on the surface, which facilitates cellular uptake via scavenger receptor-mediated endocytosis. FD17 enables the delivery of mRNAs encoding CRE, Cas9, and base editor hyCBE for efficient genome editing. The material mediates CRISPR/Cas9 gene therapy via intraocular injection effectively down-regulates vascular endothelial growth factor A in retinal pigment epithelial cells of mice, yielding promising therapeutic responses against laser-induced choroidal neovascularization. The discovered material in this study shows great promise for the development of mRNA therapeutics to combat a wide range of diseases.}, archive = {J_ADVS}, author = {Jia Lv and Qianqian Fan and Yirou Zhang and Xujiao Zhou and Panting Yu and Xin Yu and Changchang Xin and Jiaxu Hong and Yiyun Cheng}, doi = {10.1002/advs.202413006}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2413006}, shortjournal = {Adv. Sci.}, title = {A serum resistant polymer with exceptional endosomal escape and mRNA delivery efficacy for CRISPR gene therapy}, volume = {12}, year = {2025}, }
• (2025). A multi-task self-supervised strategy for predicting molecular properties and FGFR1 inhibitors. ADVS, 12(13), 2412987. (www)

  @article{ , abstract = {Studying the molecular properties of drugs and their interactions with human targets aids in better understanding the clinical performance of drugs and guides drug development. In computer-aided drug discovery, it is crucial to utilize effective molecular feature representations for predicting molecular properties and designing ligands with high binding affinity to targets. However, designing an effective multi-task and self-supervised strategy remains a significant challenge for the pretraining framework. In this study, a multi-task self-supervised deep learning framework is proposed, MTSSMol, which utilizes ≈10 million unlabeled drug-like molecules for pretraining to identify potential inhibitors of fibroblast growth factor receptor 1 (FGFR1). During the pretraining of MTSSMol, molecular representations are learned through a graph neural networks (GNNs) encoder. A multi-task self-supervised pretraining strategy is proposed to fully capture the structural and chemical knowledge of molecules. Extensive computational tests on 27 datasets demonstrate that MTSSMol exhibits exceptional performance in predicting molecular properties across different domains. Moreover, MTSSMol's capability is validated to identify potential inhibitors of FGFR1 through molecular docking using RoseTTAFold All-Atom (RFAA) and molecular dynamics simulations. Overall, MTSSMol provides an effective algorithmic framework for enhancing molecular representation learning and identifying potential drug candidates, offering a valuable tool to accelerate drug discovery processes. All of the codes are freely available online at https:// github.com/zhaoqi106/MTSSMol.}, archive = {J_ADVS}, author = {Xin Yang and Yang Wang and Ye Lin and Mingxuan Zhang and Ou Liu and Jianwei Shuai and Qi Zhao}, doi = {10.1002/advs.202412987}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412987}, shortjournal = {Adv. Sci.}, title = {A multi-task self-supervised strategy for predicting molecular properties and FGFR1 inhibitors}, volume = {12}, year = {2025}, }
• (2025). Lone pair and unique N-bridging of novel titanium nitridophosphate. ADVS, 12(13), 2412830. (www)

  @article{ , abstract = {In exploring advanced materials for solar power, the novel titanium nitridophosphate (TiP 4 N 8 ) stands out due to its unique linear nitrogen bridging. To investigate the elemental interactions responsible for the photovoltaic performance under visible light, the titanium L 2, 3 -edges and nitrogen K-edge are specifically explored using X-ray absorption spectroscopy (XAS), X-ray emission spectroscopy (XES), and resonant inelastic X-ray scattering (RIXS) techniques to map the unoccupied and occupied electronic states. It is shown that the indirect interaction between the linear nitrogen bearing the lone pair and titanium is responsible for the bandgap of 1.55 ± 0.30 eV and 1.77 ± 0.30 eV in the β- and α-TiP 4 N 8 phases as well as the stability of the α-phase. The formal oxidation state of the Ti ion in the β- and α-phases are also validated to be trivalent (Ti +3 ) and both trivalent (Ti +3 ) and tetravalent (Ti +4 ), respectively.}, archive = {J_ADVS}, author = {Peter Ufondu and Sakshi and Teak D. Boyko and Monika M. Pointner and Wolfgang Schnick and Alexander Moewes}, doi = {10.1002/advs.202412830}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412830}, shortjournal = {Adv. Sci.}, title = {Lone pair and unique N-bridging of novel titanium nitridophosphate}, volume = {12}, year = {2025}, }
• (2025). Metabolic engineering of corynebacterium glutamicum for high-level production of 1,5-pentanediol, a c5 diol platform chemical. ADVS, 12(13), 2412670. (www)

  @article{ , abstract = {The biobased production of chemicals is essential for advancing a sustainable chemical industry. 1,5-Pentanediol (1,5-PDO), a five-carbon diol with considerable industrial relevance, has shown limited microbial production efficiency until now. This study presents the development and optimization of a microbial system to produce 1,5-PDO from glucose in Corynebacterium glutamicum via the l -lysine-derived pathway. Engineering began with creating a strain capable of producing 5-hydroxyvaleric acid (5-HV), a key precursor to 1,5-PDO, by incorporating enzymes from Pseudomonas putida (DavB, DavA, and DavT) and Escherichia coli ( YahK). Two conversion pathways for further converting 5-HV to 1,5-PDO are evaluated, with the CoA-independent pathway—utilizing Mycobacterium marinum carboxylic acid reductase (CAR) and E. coli YqhD—proving greater efficiency. Further optimization continues with chromosomal integration of the 5-HV module, increasing 1,5-PDO production to 5.48 g L −1 . An additional screening of 13 CARs identifies Mycobacterium avium K-10 (MAP1040) as the most effective, and its engineered M296E mutant further increases production to 23.5 g L −1 . A deep-learning analysis reveals that Gluconobacter oxydans GOX1801 resolves the limitations of NADPH, allowing the final strain to produce 43.4 g L −1 1,5-PDO without 5-HV accumulation in fed-batch fermentation. This study demonstrates systematic approaches to optimizing microbial biosynthesis, positioning C. glutamicum as a promising platform for sustainable 1,5-PDO production.}, archive = {J_ADVS}, author = {Yu Jung Sohn and Se-Yeun Hwang and Haeyoung Lee and Subeen Jeon and Ji Young Park and Jaehyung Kim and Donghyuk Kim and Ki Jun Jeong and Sang Yup Lee and Jeong Chan Joo and Jin-Byung Park and Si Jae Park}, doi = {10.1002/advs.202412670}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412670}, shortjournal = {Adv. Sci.}, title = {Metabolic engineering of corynebacterium glutamicum for high-level production of 1,5-pentanediol, a c5 diol platform chemical}, volume = {12}, year = {2025}, }
• (2025). Multifunctional boron-based 2D nanoplatforms ameliorate severe respiratory inflammation by targeting multiple inflammatory mediators. ADVS, 12(13), 2412626. (www)

  @article{ , abstract = {Effective management of serious respiratory diseases, such as asthma and recalcitrant rhinitis, remains a global challenge. Here, it is shown that induced sputum supernatants (ISS) from patients with asthma contain higher levels of cell-free DNA (cfDNA) compared to that of healthy volunteers. Although cfDNA scavenging strategies have been developed for inflammation modulation in previous studies, this fall short in clinical settings due to the excessive neutrophil extracellular trap (NET) formation, reactive oxygen and nitrogen species (RONS) and bacterial infections in injured airway tissues. Based on this, a multifunctional boron-based 2D nanoplatform B-P M is designed by coating boron nanosheets (B-NS) with polyamidoamine generation 1 (PG1) dendrimer, which can simultaneously target cfDNA, NETs, RONS, and bacteria. The effects of B-P M in promoting mucosal repair, reducing airway inflammation, and mucus production have been demonstrated in model mice, and the therapeutic effect is superior to dexamethasone. Furthermore, flow cytometry with clustering analysis and transcriptome analysis with RNA-sequencing are adopted to comprehensively evaluate the in vivo anti-inflammation therapeutic effects. These findings emphasize the significance of a multi-targeting strategy to modulate dysregulated inflammation and highlight multifunctional boron-based 2D nanoplatforms for the amelioration of respiratory inflammatory diseases.}, archive = {J_ADVS}, author = {Changyi Xu and Ming Liu and Xinran Xie and Zhixin Li and Yuefei Zhu and Yang Ye and Mengya Du and Suhua Hu and Tianrun Liu and Yubiao Guo and Weiping Wen and Huanliang Liu and Zhaoxu Tu}, doi = {10.1002/advs.202412626}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412626}, shortjournal = {Adv. Sci.}, title = {Multifunctional boron-based 2D nanoplatforms ameliorate severe respiratory inflammation by targeting multiple inflammatory mediators}, volume = {12}, year = {2025}, }
• (2025). A spleen-targeted tolerogenic mRNA-LNPs vaccine for the treatment of experimental asthma. ADVS, 12(13), 2412543. (www)

  @article{ , abstract = {Lipid nanoparticles (LNPs)-based mRNA vaccines have witnessed their great advantages in the fight against infectious diseases. However, the pro-inflammatory properties of mRNA-LNPs vaccines may hinder the induction of antigen-specific tolerogenic immune responses. Here, it is demonstrated that stearic acid-doped LNPs co-loaded with nucleoside-modified mRNA and celastrol selectively target spleen, convert their adjuvanticity and promote a tolerogenic rather than immunogenic DCs phenotype. Furthermore, the tolerogenic mRNA vaccine also invokes the generation of antigen-specific regulatory T cells (Tregs) in the spleen and migration of the induced Tregs to the lung. In a mouse model of allergic asthma, immunization with the tolerogenic mRNA vaccine significantly alleviated symptom induction, reducing eosinophilic granulocyte accumulation and mucus secretion. In conclusion, this spleen-targeted mRNA-LNPs vaccine platform induces tolerogenic immune responses, offering promise for the development of therapeutics against allergic asthma and other conditions requiring immune tolerance modulation.}, archive = {J_ADVS}, author = {Fazhan Wang and Jia Lou and Xiaohan Lou and Fang Wu and Xiaoke Gao and Xiaohan Yao and Jiajia Wan and Xixi Duan and Wenjing Deng and Lixia Ma and Lijing Zhang and Guangjie He and Ming Wang and Chen Ni and Ningjing Lei and Zhihai Qin}, doi = {10.1002/advs.202412543}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412543}, shortjournal = {Adv. Sci.}, title = {A spleen-targeted tolerogenic mRNA-LNPs vaccine for the treatment of experimental asthma}, volume = {12}, year = {2025}, }
• (2025). DeepInterAware: Deep interaction interface-aware network for improving antigen-antibody interaction prediction from sequence data. ADVS, 12(13), 2412533. (www)

  @article{ , abstract = {Identifying interactions between candidate antibodies and target antigens is a key step in developing effective human therapeutics. The antigen–antibody interaction (AAI) occurs at the structural level, but the limited structure data poses a significant challenge. However, recent studies revealed that structural information can be learned from the vast amount of sequence data, indicating that the interaction prediction can benefit from the abundance of antigen and antibody sequences. In this study, DeepInterAware (deep interaction interface-aware network) is proposed, a framework dynamically incorporating interaction interface information directly learned from sequence data, along with the inherent specificity information of the sequences. Experimental results in interaction prediction demonstrate that DeepInterAware outperforms existing methods and exhibits promising inductive capabilities for predicting interactions involving unseen antigens or antibodies, and transfer capabilities for similar tasks. More notably, DeepInterAware has unique advantages that existing methods lack. First, DeepInterAware can dive into the underlying mechanisms of AAIs, offering the ability to identify potential binding sites. Second, it is proficient in detecting mutations within antigens or antibodies, and can be extended for precise predictions of the binding free energy changes upon mutations. The HER2-targeting antibody screening experiment further underscores DeepInterAware's exceptional capability in identifying binding antibodies for target antigens, establishing it as an important tool for antibody screening.}, archive = {J_ADVS}, author = {Yuhang Xia and Zhiwei Wang and Feng Huang and Zhankun Xiong and Yongkang Wang and Minyao Qiu and Wen Zhang}, doi = {10.1002/advs.202412533}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412533}, shortjournal = {Adv. Sci.}, title = {DeepInterAware: Deep interaction interface-aware network for improving antigen-antibody interaction prediction from sequence data}, volume = {12}, year = {2025}, }
• (2025). Deep learning combined with quantitative Structure‒Activity relationship accelerates de novo design of antifungal peptides. ADVS, 12(13), 2412488. (www)

  @article{ , abstract = {Novel antifungal drugs that evade resistance are urgently needed for Candida infections. Antifungal peptides (AFPs) are potential candidates due to their specific mechanism of action, which makes them less prone to developing drug resistance. An AFP de novo design method, Deep Learning-Quantitative Structure‒Activity Relationship Empirical Screening (DL-QSARES), is developed by integrating deep learning and quantitative structure‒activity relationship  empirical screening. After generating candidate AFPs (c_AFPs) through the recombination of dominant amino acids and dipeptide compositions, natural language processing models are utilized and quantitative structure‒activity relationship (QSAR) approaches based on physicochemical properties to screen for promising c_AFPs. Forty-nine promising c_AFPs are screened, and their minimum inhibitory concentrations (MICs) against C. albicans are determined to be 3.9–125 µg mL −1 , of which four leading c_AFPs (AFP-8, −10, −11, and −13) has MICs of <10 µg mL −1 against the four tested pathogenic fungi, and AFP-13 has excellent therapeutic efficacy in the animal model.}, archive = {J_ADVS}, author = {Kedong Yin and Ruifang Li and Shaojie Zhang and Yiqing Sun and Liang Huang and Mengwan Jiang and Degang Xu and Wen Xu}, doi = {10.1002/advs.202412488}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412488}, shortjournal = {Adv. Sci.}, title = {Deep learning combined with quantitative Structure‒Activity relationship accelerates de novo design of antifungal peptides}, volume = {12}, year = {2025}, }
• (2025). Optogenetically activatable MLKL as a standalone functional module for necroptosis and therapeutic applications in antitumoral immunity. ADVS, 12(13), 2412393. (www)

  @article{ , abstract = {Necroptosis plays a crucial role in the progression of various diseases and has gained substantial attention for its potential to activate antitumor immunity. However, the complex signaling networks that regulate necroptosis have made it challenging to fully understand its mechanisms and translate this knowledge into therapeutic applications. To address these challenges, an optogenetically activatable necroptosis system is developed that allows for precise spatiotemporal control of key necroptosis regulators, bypassing complex upstream signaling processes. The system, specifically featuring optoMLKL, demonstrates that it can rapidly assemble into functional higher-order “hotspots” within cellular membrane compartments, independent of RIPK3-mediated phosphorylation. Moreover, the functional module of optoMLKL significantly enhances innate immune responses by promoting the release of iDAMPs and cDAMPs, which are critical for initiating antitumor immunity. Furthermore, optoMLKL exhibits antitumor effects when activated in patient-derived pancreatic cancer organoids, highlighting its potential for clinical application. These findings will pave the way for innovative cancer therapies by leveraging optogenetic approaches to precisely control and enhance necroptosis.}, archive = {J_ADVS}, author = {Da-Hye Jeong and Seokhwi Kim and Han-Hee Park and Kyoung-Jin Woo and Jae-Il Choi and Minji Choi and Jisoo Shin and So Hyun Park and Myung-Wook Seon and Dakeun Lee and Jong-Ho Cha and You-Sun Kim}, doi = {10.1002/advs.202412393}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412393}, shortjournal = {Adv. Sci.}, title = {Optogenetically activatable MLKL as a standalone functional module for necroptosis and therapeutic applications in antitumoral immunity}, volume = {12}, year = {2025}, }
• (2025). HUWE1-mediated degradation of MUTYH facilitates DNA damage and mitochondrial dysfunction to promote acute kidney injury. ADVS, 12(13), 2412250. (www)

  @article{ , abstract = {The role of MUTYH, a DNA repair glycosylase in the pathogenesis of acute kidney injury (AKI) is unclear. In this study, it is found that MUTYH protein levels are significantly decreased in the kidneys of cisplatin- or folic acid (FA)-induced mouse AKI models and patients with AKI. MUTYH deficiency aggravates renal dysfunction and tubular injury following cisplatin and FA treatment, along with the accumulation of 7, 8-dihydro-8-oxoguanine (8-oxoG) and impairs mitochondrial function. Importantly, the overexpression of type 2 MUTYH (nuclear) significantly ameliorates cisplatin-induced apoptosis, oxidative stress, mitochondrial dysfunction, and DNA damage in vivo and in vitro. In contrast, overexpression of type 1 MUTYH (mitochondrial) shows a marginal effect against cisplatin-induced injury, indicating the chief role of type 2 MUTYH in antagonizing AKI. Interestingly, the results also indicate that the upregulation of the E3 ligase HUWE1 causes the ubiquitination and degradation of MUTYH in tubular epithelial cells. HUWE1 knockout or treatment with the HUWE1 inhibitor BI8622 significantly protect against cisplatin-induced AKI. Taken together, these results suggest that the ubiquitin E3 ligase HUWE1-mediates ubiquitination and degradation of MUTYH can aggravate DNA damage in the nucleus and mitochondria and promote AKI. Targeting the HUWE1/MUTYH pathway may be a potential strategy for AKI treatment.}, archive = {J_ADVS}, author = {Yunwen Yang and Peipei Wang and Kaiqian Zhou and Wen Zhang and Suwen Liu and Jing Ouyang and Mi Bai and Guixia Ding and Songming Huang and Zhanjun Jia and Aihua Zhang}, doi = {10.1002/advs.202412250}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412250}, shortjournal = {Adv. Sci.}, title = {HUWE1-mediated degradation of MUTYH facilitates DNA damage and mitochondrial dysfunction to promote acute kidney injury}, volume = {12}, year = {2025}, }
• (2025). Structural basis and mechanism of a unique haemophore in the haem-iron acquisition by riemerella anatipestifer. ADVS, 12(13), 2412202. (www)

  @article{ , abstract = {Several bacterial pathogens employ haemophores to scavenge haem from host haemoprotein to obtain an iron source. However, no homologues of well-characterized haemophores are found in Riemerella anatipestifer , a bacterium belonging to the order Flavobacteriales that encodes haem uptake systems. Herein, a unique haemophore RhuH is characterized in this bacterium. R. anatipestifer used RhuH to grow when duck hemoglobin serves as the sole iron resource. RhuH is secreted as a component of outer membrane vesicles. Recombinant RhuH exhibited a high binding affinity for haem ( K d of 3.44 × 10 −11 m ) and can extract haem from duck hemoglobin. X-ray crystallography elucidated the 3D structure of RhuH at 2.85 Å resolution, showing a dimeric conformation with each monomer exhibiting a unique structure. Structure modeling of RhuH-haem, coupled with mutagenesis, haemin utilization, and binding affinity assays, show that haem is captured in the β-barrel–like region, displaying the classic iron coordination. The RhuH homologues are predominantly distributed in Weeksellaceae and Flavobacteriaceae . Finally, the homologues of RhuH in Riemerella columbina , Flavobacterium columnare , and Flavobacterium soli are used as a proof of concept, demonstrating that these homologues exhibit conserved structures and functions.}, archive = {J_ADVS}, author = {Mengying Wang and Dandan Zhang and Xiu Tian and Jiangyang Tong and Yizhou Yao and Mingshu Wang and Dekang Zhu and Renyong Jia and Shun Chen and Xinxin Zhao and Shaqiu Zhang and Juan Huang and Xumin Ou and Bin Tian and Di Sun and Yu He and Zhen Wu and Songying Ouyang and Mafeng Liu and Anchun Cheng}, doi = {10.1002/advs.202412202}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412202}, shortjournal = {Adv. Sci.}, title = {Structural basis and mechanism of a unique haemophore in the haem-iron acquisition by riemerella anatipestifer}, volume = {12}, year = {2025}, }
• (2025). HnRNPC functions with HuR to regulate alternative splicing in an m6A-dependent manner and is essential for meiosis. ADVS, 12(13), 2412196. (www)

  @article{ , abstract = {N6-methyladenosine (m6A) and its reader proteins are involved in pre-mRNA processing and play a variety of roles in numerous biological processes. However, much remains to be understood about the regulation of m6A and the function of its specific readers during meiotic processes. Here, this study shows that the potential m6A reader protein hnRNPC is essential for both male and female meiosis in mice. Germ cell-specific knockout of Hnrnpc causes meiotic arrest at pachynema in male mice. Specifically, hnRNPC-deficient males show abnormal meiosis initiation and defective meiotic progression, ultimately leading to meiotic arrest at the pachytene stage. Interestingly, hnRNPC-null females show similar meiotic defects to males. Mechanistically, this study discovers that in male germ cells, hnRNPC works with HuR to directly bind and modulate alternative splicing of meiotic-related genes (e.g., Sycp1 , Brca1 , and Smc5 ) in an m6A-dependent manner during spermatogenesis. Collectively, these findings reveal hnRNPC as a critical factor for meiosis and contribute to a mechanistic understanding of the hnRNPC-HuR interaction in alternative splicing of mRNAs during germ cell development.}, archive = {J_ADVS}, author = {Xinxin Xiong and Shenglei Feng and Xixiang Ma and Kuan Liu and Yiqian Gui and Bei Chen and Xu Fan and Fengli Wang and Xiaoli Wang and Shuiqiao Yuan}, doi = {10.1002/advs.202412196}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412196}, shortjournal = {Adv. Sci.}, title = {HnRNPC functions with HuR to regulate alternative splicing in an m6A-dependent manner and is essential for meiosis}, volume = {12}, year = {2025}, }
• (2025). Nanoenhanced-cuproptosis results from the synergy of calcium overload and GSH depletion with the increasing of intracellular Ca/Mn/Cu ions. ADVS, 12(13), 2412067. (www)

  @article{ , abstract = {Cuproptosis is a newly discovered copper-dependent form of cell death. Intracellular glutathione (GSH) acts as a copper chelator to inhibit cuproptosis, so the reduction of GSH concentration is conducive to enhancing the cuproptosis of cells. In order to reduce GSH content and interfere with mitochondrial metabolism, a strategy based on calcium overload and GSH depletion to enhance cuproptosis is proposed in this study. Containing manganese (Mn) and copper (Cu) elements, CaCO 3 nanoparticles (NPs) are modified with MCF-7 cell aptamer (CaCO 3 /Mn/Cu@lip-Apt). When entering the cell, CaCO 3 /Mn/Cu@lip-Apt decomposed and released Mn* (Mn 2+ /Mn 3+ /Mn 4+ ), Cu 2+ and Ca 2+ . The high valence Mn ion in Mn* can effectively consume GSH to produce Mn 2+ which catalyzed H 2 O 2 to produce reactive oxygen species (ROS), while reducing the GSH concentration. The production of ROS promoted the influx of exogenous Ca 2+ . The large accumulation of Ca 2+ led to intracellular calcium overload, resulting in mitochondrial dysfunction and metabolism disorders. The depletion of GSH promoted the accumulation of Cu 2+ , which in turn triggered cuproptosis. This strategy showed excellent antitumor effects and provided a new way to study disease treatment.}, archive = {J_ADVS}, author = {Shiwei Liu and Wennan Yan and Wenyue Zhang and Ji Zhang and Ziyi Li and Yingshu Guo and Hong-Yuan Chen and Jing-Juan Xu}, doi = {10.1002/advs.202412067}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2412067}, shortjournal = {Adv. Sci.}, title = {Nanoenhanced-cuproptosis results from the synergy of calcium overload and GSH depletion with the increasing of intracellular Ca/Mn/Cu ions}, volume = {12}, year = {2025}, }
• (2025). Enhancer RNA transcriptome-wide association study reveals a distinctive class of pan-cancer susceptibility eRNAs. ADVS, 12(13), 2411974. (www)

  @article{ , abstract = {Many cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)-mediated genetic effects from 28 033 RNA sequencing samples across 11 606 individuals, identifying 21 073 eRNA quantitative trait loci (eRNA-QTLs) significantly associated with eRNA expression. Mechanistically, eRNA-QTLs frequently altered binding motifs of transcription factors. In addition, 28.48% of cancer risk variants are strongly colocalized with eRNA-QTLs. A pan-cancer eRNA-based transcriptome-wide association study is conducted across 23 major cancer types, identifying 626 significant cancer susceptibility eRNAs predicted to modulate cancer risk via eRNA, from which 54.90% of the eRNA target genes are overlooked by traditional gene expression studies, and most are essential for cancer cell proliferation. As proof of principle validation, the enhancer functionality of two newly identified susceptibility eRNAs, CCND1e and SNAPC1e , is confirmed through CRISPR inhibition and shRNA-mediated knockdown, resulting in a marked decrease in the expression of their respective target genes, consequently suppressing the proliferation of prostate cancer cells. The study underscores the essential role of eRNA in unveiling new cancer susceptibility genes and establishes a strong framework for enhancing our understanding of human cancer etiology.}, archive = {J_ADVS}, author = {Wenyan Chen and Zeyang Wang and Yinuo Wang and Jianxiang Lin and Shuxin Chen and Hui Chen and Xuelian Ma and Xudong Zou and Xing Li and Yangmei Qin and Kewei Xiong and Xixian Ma and Qi Liao and Yunbo Qiao and Lei Li}, doi = {10.1002/advs.202411974}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2411974}, shortjournal = {Adv. Sci.}, title = {Enhancer RNA transcriptome-wide association study reveals a distinctive class of pan-cancer susceptibility eRNAs}, volume = {12}, year = {2025}, }
• (2025). IRAP drives ribosomal degradation to refuel energy for platelet activation during septic thrombosis. ADVS, 12(13), 2411914. (www)

  @article{ , abstract = {Platelets play crucial roles in multiple pathophysiological processes after energy-dependent activation. It is puzzling how such a small cellular debris has abundant energy supply. In this study, it is shown that insulin-regulated aminopeptidase (IRAP), a type II transmembrane protein, is a key regulator for platelet activation by promoting energy regeneration during septic thrombosis. Through interaction with certain endosome membrane proteins, IRAP can not only promote granule release, but also facilitate lysosomal degradation of theoretically discarded ribosomes in an mTORC1- and S-acylation-dependent manner in activated platelets. Plentiful amino acids obtained from IRAP-mediated ribophagy are recruited to aerobic glycolysis and then promote energy metabolism reprogramming, thereby producing abundant energy for platelet life extension and prolonged activation. Consequently, targeted blocking IRAP can dramatically alleviate platelet hyperactivation and septic thrombosis.}, archive = {J_ADVS}, author = {Baichuan Xu and Xianpeng Ye and Kangfu Sun and Liang Chen and Zhaoyang Wen and Qigang Lan and Jun Chen and Mo Chen and Mingqiang Shen and Song Wang and Yang Xu and Xi Zhang and Jinghong Zhao and Junping Wang and Shilei Chen}, doi = {10.1002/advs.202411914}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2411914}, shortjournal = {Adv. Sci.}, title = {IRAP drives ribosomal degradation to refuel energy for platelet activation during septic thrombosis}, volume = {12}, year = {2025}, }
• (2025). Electret-inspired charge-injected hydrogel for scar-free healing of bacterially infected burns through bioelectrical stimulation and immune modulation. ADVS, 12(13), 2411889. (www)

  @article{ , abstract = {In this study, an electret-inspired, charge-injected hydrogel called QOSP hydrogel (QCS/OD/SDI/PANI/PS/Plasma) that promotes scar-free healing of bacteria-infected burns through bioelectrical stimulation and immune modulation, is presented. The hydrogel, composed of quaternized chitosan (QCS), oxidized dextran (OD), sulfadiazine (SDI), polystyrene (PS), and polyaniline nanowires (PANI), forms a conductive network capable of storing and releasing electric charges, emulating an electret-like mechanism. This structure delivers bioelectrical signals continuously, enhancing wound healing by regulating immune responses and minimizing fibrosis. In a mouse model of second-degree burns infected with Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the hydrogel accelerates wound healing by 32% and reduces bacterial load by 60%, significantly inhibited scar formation by 40% compared to controls. QOSP hydrogel modulates the Th1/Th2 immune balance toward a Th1-dominant antifibrotic state through quaternized chitosan, thereby reducing collagen deposition by 35%. Electro-dielectric characterization reveals a dielectric constant of 6.2, a 34% improvement in conductivity (3.33 × 10 −5 S/m) and a 30 °C increase in thermal stability. Proteomic analysis highlights a 50% down-regulation of pro-inflammatory and pro-fibrotic pathways, suggesting a controlled immune response conducive to scar-free healing. This study underscores the potential of bioelectrically active hydrogels as a novel approach for treating infected wounds prone to scarring.}, archive = {J_ADVS}, author = {Mujie Liu and Yuheng Wang and Haodong Wang and Lihong Qi and Yuxuan Shang and Jiajie Song and Xiulong Feng and Yiwei Chen and Waqar Ali Memon and Yuping Shen and Xiaodong Wu and Jiangbei Cao and Yifan Zhao and Zhuangde Jiang and Dingxin Liu and Shareen Shafique and Shengtao Li and Guanghao Lu and Zhixiang Wei and Zhijie Liu and Kun Zhou and Yuping Quan and Xiaoyu Zhang and Xin Zou and Xuefeng Wang and Na Liu and Yaqing Zhang and Yiwei Hu and Chao Han and Wen Wang}, doi = {10.1002/advs.202411889}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2411889}, shortjournal = {Adv. Sci.}, title = {Electret-inspired charge-injected hydrogel for scar-free healing of bacterially infected burns through bioelectrical stimulation and immune modulation}, volume = {12}, year = {2025}, }
• (2025). Phosphorylation of POU3F3 mediated nuclear translocation promotes proliferation in non-small cell lung cancer through accelerating ATP5PF transcription and ATP production. ADVS, 12(13), 2411503. (www)

  @article{ , abstract = {Targeting oxidative phosphorylation (OXPHOS) through inhibiting the electron transport chain (ETC) has shown promising pre-clinical efficacy in cancer therapy. Although aerobic glycolysis is a hallmark of cancer, emerging evidence suggest OXPHOS is frequently enhanced, providing metabolic advantages for cell proliferation, metastasis, and drug resistance in a variety of aggressive cancer types including non-small cell lung cancer (NSCLC), yet the underlying molecular mechanisms remain elusive. Here it is reported that POU-domain containing family protein POU3F3 is translocated into the nuclei of NSCLC cell lines harboring mutant RAS, where it activates transcription of ATP5PF, an essential component of mitochondrial ATP synthase and consequent ATP production, leading to enhanced NSCLC proliferation and migration. Moreover, it is further found out that ERK1 phosphorylates POU3F3 at the S393 site in the cytoplasm and promotes the nuclear translocation of POU3F3 via receptor importin β1 in RAS mutant NSCLC cells. Mechanistically, RNA sequencing analysis combined with chromatin immunoprecipitation (ChIP) assay revealed that POU3F3 binds to the promoter of ATP5PF, leading to enhanced ATP5PF transcription and ATP production. Together, this study uncovers a novel RAS-POU3F3-ATP5PF axis in facilitating NSCLC progression, providing a new perspective on the understanding of molecular mechanisms for NSCLC progression.}, archive = {J_ADVS}, author = {Qi-Gang Zeng and Le Li and Tao Chang and Yong Sun and Bin Zheng and Ling-Na Xue and Chao-Ling Liu and Xia-Qing Li and Ruo-Tong Huang and Jia-Xin Gu and Zhao-Rong An and Hao-Tao Yao and Dan-Yang Zhou and Jun Fan and Yong Dai}, doi = {10.1002/advs.202411503}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2411503}, shortjournal = {Adv. Sci.}, title = {Phosphorylation of POU3F3 mediated nuclear translocation promotes proliferation in non-small cell lung cancer through accelerating ATP5PF transcription and ATP production}, volume = {12}, year = {2025}, }
• (2025). Data-driven theoretical modeling of centrifugal step emulsification and its application in comprehensive multiscale analysis. ADVS, 12(13), 2411459. (www)

  @article{ , abstract = {Tailored droplet generation is crucial for droplet microfluidics that involve samples of varying sizes. However, the absence of precise predictive models forces droplet platforms to rely on empiricism derived from extensive experiments, underscoring the need for comprehensive modeling analysis. To address this, a novel customized assembled centrifugal step emulsifier (CASE) is presented by incorporating a “jigsaw puzzles” design to efficiently acquire large-scale experimental data. Numerical simulations are utilized to analyze fluid configurations during step emulsification, identifying a key connection tube that determines droplet size. By training and verifying with the experimental and simulation datasets, a comprehensive theoretical model is established that allows for the preliminary design of the droplet size and generation frequency with an average error rate of 4.8%, successfully filling a critical gap in existing field. This predictive model empowers the CASE to achieve all-in-one functionality, including droplet pre-design, generation, manipulation, and on-site detection. As a proof of concept, multiscale sample analysis ranging from nanoscale nucleic acids to microscale bacteria and 3D cell spheroids is realized in the CASE. In summary, this platform offers valuable guidance for customized droplet generation by centrifugal step emulsifiers and promotes the adoption of droplet microfluidics in biochemical assays.}, archive = {J_ADVS}, author = {Xin Wang and Xiaolu Cai and Chao Wan and Huijuan Yuan and Shunji Li and Yiwei Zhang and Ran Zhao and Yuxi Qin and Yiwei Li and Bi-Feng Liu and Peng Chen}, doi = {10.1002/advs.202411459}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2411459}, shortjournal = {Adv. Sci.}, title = {Data-driven theoretical modeling of centrifugal step emulsification and its application in comprehensive multiscale analysis}, volume = {12}, year = {2025}, }
• (2025). A feedback loop driven by H4K12 lactylation and HDAC3 in macrophages regulates lactate-induced collagen synthesis in fibroblasts via the TGF-β signaling. ADVS, 12(13), 2411408. (www)

  @article{ , abstract = {The decrease in fibroblast collagen is a primary contributor to skin aging. Lactate can participate in collagen synthesis through lysine lactylation by regulating gene transcription. However, the precise mechanism by which lactate influences collagen synthesis requires further investigation. This study demonstrates that the depletion of macrophages mitigates the stimulating effect of lactate on collagen synthesis in fibroblasts. Through joint CUT&Tag and RNA-sequencing analyses, a feedback loop between H4K12 lactylation (H4K12la) and histone deacetylase 3 (HDAC3) in macrophages that drives lactate-induced collagen synthesis are identified. Macrophages can uptake extracellular lactate via monocarboxylate transporter-1 (MCT1), leading to an up-regulation of H4K12la levels through a KAT5-KAT8-dependent mechanism in response to Poly-L-Lactic Acid (PLLA) stimulation, a source of low concentration and persistent lactate, thereby promoting collagen synthesis in fibroblasts. Furthermore, H4K12la is enriched at the promoters of TGF-β1 and TGF-β3, enhancing their transcription. Hyperlactylation of H4K12la inhibits the expression of the eraser HDAC3, while the activation of HDAC3 reduces H4K12la in macrophages and suppresses collagen synthesis in fibroblasts. In conclusion, this study illustrates that macrophages play a critical role in lactate-induced collagen synthesis in the skin, and targeting the lactate-H4K12la-HDAC3-TGF-β axis may represent a novel approach for enhancing collagen production to combat skin aging.}, archive = {J_ADVS}, author = {Ying Zou and Mibu Cao and Meiling Tai and Haoxian Zhou and Li Tao and Shu Wu and Kaiye Yang and Youliang Zhang and Yuanlong Ge and Hao Wang and Shengkang Luo and Zhenyu Ju}, doi = {10.1002/advs.202411408}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2411408}, shortjournal = {Adv. Sci.}, title = {A feedback loop driven by H4K12 lactylation and HDAC3 in macrophages regulates lactate-induced collagen synthesis in fibroblasts via the TGF-β signaling}, volume = {12}, year = {2025}, }
• (2025). One-step formed janus hydrogel with time-space regulating properties for suture-free and high-quality tendon healing. ADVS, 12(13), 2411400. (www)

  @article{ , abstract = {Janus hydrogels have promising applications in tendon healing and anti-peritendinous adhesions. However, their complicated preparation methods, weak mechanical properties, and unstable adhesion interfaces have severely limited their application in suture-free and high-quality tendon healing. In this work, by controlling the interfacial distribution of free -COOH groups and cationic-π structures on both sides of the hydrogels, a series of PZBA-EGCG-ALC Janus hydrogels with varying degrees of asymmetric properties are successfully prepared using a simple and efficient one-step synthesis method. The tensile strength and elongation at the break of the Janus hydrogel are as high as 0.51 ± 0.04 MPa and 922.89 ± 28.59%. In addition, the Janus hydrogel can achieve a high difference in adhesion strength (nearly 20-fold) while maintaining a strong adhesion strength on their bottom sides (up to 524.8 ± 33.1 J m −2 ). In the spatial dimension, its excellent mechanical compliance and one-sided adhesion behavior can provide effective mechanical support and physical barriers for the injured Achilles tendons. More importantly, the Janus hydrogel can also minimize early inflammation generation in the time dimension via its ROS-responsive PZBA-EGCG prodrug macromolecules. This study provided a more effective and convenient suture-free strategy for constructing Janus hydrogels to promote high-quality tendon healing.}, archive = {J_ADVS}, author = {Chenguang Ouyang and Tian Tu and Haojie Yu and Li Wang and Zhipeng Ni and Jian Yang and Yanzhao Dong and Xiaodi Zou and Weijie Zhou and Jinyi Liu and Dingning Chen and Yu Wang and Xudong Wu and Hong Yi and Xunchun Yuan and Zhenfeng Liu and Hui Lu}, doi = {10.1002/advs.202411400}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2411400}, shortjournal = {Adv. Sci.}, title = {One-step formed janus hydrogel with time-space regulating properties for suture-free and high-quality tendon healing}, volume = {12}, year = {2025}, }
• (2025). High-efficiency, long-lifetime and color-tunable hybrid WOLEDs using a platinum complex with voltage-dependent monomer and aggregate emission. ADVS, 12(13), 2411364. (www)

  @article{ , abstract = {Color-tunable white organic light-emitting diodes (CT-WOLEDs) have attracted widespread attention given their large color variation to meet the different daily scenarios from the perspective of circadian rhythm. However, most reported CT-WOLEDs, especially the tri-color devices, exhibit poor performances and sophisticated structures. Here, a simple structure tri-color CT-WOLED is demonstrated that simultaneously exhibits high efficiency, ultralong operation lifetime, and wide color-tunable range for dynamic sunlight emulation. The design is based on a newly developed platinum complex that can emit light efficiently in both monomer and aggregation states, providing voltage-dependent green-to-red phosphorescence emission, not only ensuring tunable colors in WOLEDs but also simplifying the device structure. Combining with a blue delayed fluorescence material, this hybrid device exhibits a wide range of tunable colors with Commission Internationale de l’Eclairage 1931 (CIE) coordinates and correlated color emperature (CCT)  shifts from (0.502, 0.474) and 2628 K at 2.6 V to (0.211, 0.334) and 14860 K at 8 V, achieving good visual alignment with sunlight color throughout the day. This same device also shows high external quantum efficiencies from 28.8% at maximum to 26.2% at 5000 cd m −2 . Furthermore, an impressively long time of 21,144 h is achieved to decay to 90% of the initial luminance at 100 cd m −2 , being the longest among recorded CT-WOLEDs.}, archive = {J_ADVS}, author = {Yangyang Xin and Mao Mao and Shuo Xu and Kaixin Tan and Gang Cheng and Hai Zhang and Hengyi Dai and Tianyu Huang and Dongdong Zhang and Lian Duan and Chi-Ming Che}, doi = {10.1002/advs.202411364}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2411364}, shortjournal = {Adv. Sci.}, title = {High-efficiency, long-lifetime and color-tunable hybrid WOLEDs using a platinum complex with voltage-dependent monomer and aggregate emission}, volume = {12}, year = {2025}, }
• (2025). ODSEI chip: An open 3D microfluidic platform for studying tumor spheroid-endothelial interactions. ADVS, 12(13), 2410659. (www)

  @article{ , abstract = {Current in vitro models of 3D tumor spheroids within the microenvironment have emerged as promising tools for understanding tumor progression and potential drug responses. However, creating spheroids with functional vasculature remains challenging in a controlled and high-throughput manner. Herein, a novel open 3D-microarray platform is presented for a spheroid-endothelium interaction (ODSEI) chip, capable of arraying more than 1000 spheroids on top of the vasculature, compartmentalized for single spheroid-level analysis of drug resistance, and allows for the extraction of specific spheroids for further analysis. As proof of concept, the crosstalk between breast cancer spheroids and vasculature is monitored, validating the roles of endothelial cells in acquired tamoxifen resistance. Cancer spheroids exhibited reduced sensitivity to tamoxifen in the presence of vasculature. Further analysis through single-cell RNA sequencing of extracted spheroids and protein arrays elucidated gene expression profiles and cytokines associated with acquired tamoxifen resistance, particularly involving the TNF-α pathway via NF-κB and mTOR signaling. By targeting the highly expressed cytokines (IL-8, TIMP1) identified, tamoxifen resistance in cancer spheroid can be effectively reversed. In summary, the ODSEI chip allows to study spheroid and endothelial interaction in various contexts, leading to improved insights into tumor biology and therapeutic strategies.}, archive = {J_ADVS}, author = {Jooyoung Ro and Junyoung Kim and Juhee Park and Yongjun Choi and Yoon-Kyoung Cho}, doi = {10.1002/advs.202410659}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2410659}, shortjournal = {Adv. Sci.}, title = {ODSEI chip: An open 3D microfluidic platform for studying tumor spheroid-endothelial interactions}, volume = {12}, year = {2025}, }
• (2025). A mitochondria-targeted biomimetic nanomedicine capable of reversing drug resistance in colorectal cancer through mitochondrial dysfunction. ADVS, 12(13), 2410630. (www)

  @article{ , abstract = {Chemoresistance and metastasis are the main obstacles to the clinical success of anticancer treatment and are responsible for most cancer deaths. Developing effective approaches to reverse chemoresistance and inhibit metastasis is essential for efficient chemotherapy. Mitochondria are important sources of cellular energy and are involved in mediating chemoresistance and driving tumor metastasis. Due to the relatively weak DNA repair capacity of mitochondria, targeting mitochondria may reverse chemoresistance and provide a paradigm for metastatic cancer treatment. Herein, exosomes (Exos) modified with integrin ligands and mitochondriotropic molecules are synthesized for encapsulating oxaliplatin (OXA) to construct a sequentially targeted and mitochondrion-dysfunctional nanodrug (OXA@Exo-RD). Subsequent investigations confirm that OXA@Exo-RD targeted cancer cells and mitochondria in sequence, and OXA delivered to mitochondria lacking DNA repair mechanisms reduce the likelihood of deactivation. Furthermore, the OXA@Exo-RD promotes the overproduction of ROS, inhibited ATP generation, and induces mitochondria-mediated apoptosis and mitochondrial dysregulation. Finally, OXA@Exo-RD shows the potential to inhibit the growth and metastasis of HCT116/OXA cells in vitro, which is further validated in subcutaneous and orthotopic CRC models, as well as in CRC metastasis models. Taken together, this dual-targeting nanomedicine induces apoptosis via mitochondrial signaling pathways, providing an attractive strategy for the treatment of drug-resistant CRC.}, archive = {J_ADVS}, author = {Xiaohui Wang and Zhiyuan Xu and Jian Wang and Chunrong Wu and Lin Zhang and Chengyuan Qian and Yang Luo and Yanjuan Gu and Wing-Tak Wong and Debing Xiang}, doi = {10.1002/advs.202410630}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2410630}, shortjournal = {Adv. Sci.}, title = {A mitochondria-targeted biomimetic nanomedicine capable of reversing drug resistance in colorectal cancer through mitochondrial dysfunction}, volume = {12}, year = {2025}, }
• (2025). Synthesizing liquid fuels over carbon-based catalysts via CO2 conversion. ADVS, 12(13), 2410280. (www)

  @article{ , abstract = {The unique characteristics of carbon materials make them flexible for applications in heterogeneous catalysis. Their interest is expanding in the conscious efforts being made toward sustainable fuel production. A notable application is the heterogenous conversion of CO 2 to liquid fuels, which exploits the characteristics of carbon materials, taking advantage of their electronic configurations, high surface area, pore properties, and synergistic role in catalysis. In this review, a critical overview of this rapidly developing field is presented. Various carbon allotropes and derivatives, as well as some strategies for fabricating carbon-based catalysts are keenly highlighted within thermal-, electro-, and photocatalytic CO 2 conversion to liquid fuels. Distinct emphasis is placed on the role of different carbon materials by investigating the unique synergy attained at catalyst interfaces, the physicochemical properties attained, and their influence in enhancing the specific liquid fuels synthesis. Finally, the work is concluded, followed by an outlook detailing key challenges that need addressing.}, archive = {J_ADVS}, author = {Cederick Cyril Amoo and Qingjie Ge and Vitaly Ordomsky and Jian Sun}, doi = {10.1002/advs.202410280}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2410280}, shortjournal = {Adv. Sci.}, title = {Synthesizing liquid fuels over carbon-based catalysts via CO2 conversion}, volume = {12}, year = {2025}, }
• (2025). Nudix hydrolase 13 impairs the initiation of colorectal cancer by inhibiting PKM1 ADP-ribosylation. ADVS, 12(13), 2410058. (www)

  @article{ , abstract = {Metabolic dysregulation has been implicated as a key factor in colorectal cancer (CRC) initiation, however, the underlying driving forces and mechanisms remain poorly understood. Herein, transcriptome profiling of paired early-stage CRCs and adenomas identifies Nudix hydrolase 13 (NUDT13) as a critical suppressor. Elevated NUDT13 expression impedes the proliferation of CRC cells under hypoxic conditions and markedly inhibits CRC initiation by upregulating PKM1. Mechanistically, NUDT13 directly binds and stabilizes PKM1 protein by reducing its poly ADP-ribosylation (PARylation), which is catalyzed by PARP1 at E275/D281/E282/E285/D296, thereby inducing an oxidative phosphorylation (OXPHOS) phenotype in CRC cells. Moreover, spatiotemporal knockout of Nudt13 enhances intestinal tumorigenesis in mice, which can be significantly suppressed by PARP1 inhibitor Olaparib. Notably, residues E245/E248/E249 within the Nudix box motif of NUDT13 are essential for PKM1 PARylation, and a mimic peptide derived from this motif is sufficient to stabilize PKM1 protein and robustly inhibit CRC tumorigenesis. Collectively, this study reveals a previously unknown PARylation-dependent mechanism that regulates PKM1 protein stability and switches the metabolic pathway of CRC cells, providing a promising target for CRC treatment.}, archive = {J_ADVS}, author = {Jinlong Lin and Yixin Yin and Jinghua Cao and Bingxu Zou and Kai Han and Yufan Chen and Siyu Li and Cijun Huang and Jiewei Chen and Yongrui Lv and Shuidan Xu and Dan Xie and Fengwei Wang}, doi = {10.1002/advs.202410058}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2410058}, shortjournal = {Adv. Sci.}, title = {Nudix hydrolase 13 impairs the initiation of colorectal cancer by inhibiting PKM1 ADP-ribosylation}, volume = {12}, year = {2025}, }
• (2025). Intestinal Gastrin/CCKBR axis protects against type 2 diabetes by reducing intestinal glucose absorption through the PI3K/Akt/eIF4B signaling pathway. ADVS, 12(13), 2410032. (www)

  @article{ , abstract = {The Gastrin/CCKBR axis is essential for inhibiting intestinal sodium absorption, but its effects on intestinal glucose metabolism remain elusive. This study aims to determine the role of intestinal Gastrin/CCKBR on glucose absorption in the development of type 2 diabetes (T2D). Intestinal epithelial cell-specific Cckbr knockout mice and control wild-type mice are fed normal diet (ND, 10% fat) or high fat diet (HFD, 60% fat) to study the effect of intestinal Gastrin/CCKBR on blood glucose levels. Gastrin-SiO 2 microspheres (20 mg kg −1 d −1 ) are designed so that gastrin specifically stimulates intestinal CCKBR, without its absorption into the circulation. Mice with silenced intestinal Cckbr has pre-diabetes mellitus (Pre-DM) that rapidly progressed into T2D when fed HFD. Moreover, Gastrin-SiO 2 microspheres markedly reduce glucose absorption in duodenum obtained from patients with T2D. In mice with HFD-induced T2D, Gastrin-SiO 2 microspheres reduce intestinal glucose absorption by down-regulating intestinal SGLT1 and GLUT2 expressions and stimulating incretin secretion. This study shows the important role of intestinal Gastrin/CCKBR in intestinal glucose absorption. Gastrin-SiO 2 microspheres may be a promising strategy for the treatment of patients with T2D.}, archive = {J_ADVS}, author = {Xue Liu and Xing Liu and Yunpeng Liu and Anxiong Long and Wei Liu and Shiyun Sun and Shuaibing Lu and Xianxian Wu and Xiaodi Jia and Pedro A Jose and Qiang Wei and Xiaoliang Jiang and Haizeng Zhang and Zhiwei Yang}, doi = {10.1002/advs.202410032}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2410032}, shortjournal = {Adv. Sci.}, title = {Intestinal Gastrin/CCKBR axis protects against type 2 diabetes by reducing intestinal glucose absorption through the PI3K/Akt/eIF4B signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Excellent thermoelectric performance realized in copper sulfide magnetic nanocomposites via modified solid states reaction. ADVS, 12(13), 2409494. (www)

  @article{ , abstract = {Solid-state reactions, which are the basic reactions involved in the preparation, processing, and application of materials, are ubiquitous in material science and chemistry research. In the fields of metallurgy and geology, a significant number of complex chemical reactions occur during the smelting of ores. Inspired by the smelting of copper concentrate, this work applies modified metallurgical chemical reactions to the field of (thermoeletric) TE materials. By controlling the reaction temperature and composition, porous copper sulfide magnetic nanocomposites can be formed. Regulating the composition generates numerous precipitates and Cu-rich phases, and controlling the microstructure facilitates the formation of porous structures. The second phase and porous structure effectively decreased thermal conductivity. Furthermore, the introduction of ferromagnetic Fe 3 O 4 particles plays a role in reducing carrier concentration and forming potential barrier scattering low energy carriers, which improves the Seebeck coefficient of the samples. Ultimately, the optimum figure of merit (ZT) of ≈1.3 at 773 K for the Cu 1.8 S + 2 wt.% Fe 3 O 4 bulk sample and an average ZT of 0.57 over the entire operating temperature range. The modified solid states reaction between oxides and sulfides could be employed to optimize electrical and thermal transport properties for sulfide TE material, as well as sulfide batteries, sulfide photoelectric materials, and sulfide catalytic materials.}, archive = {J_ADVS}, author = {Tian-Yu Yang and Zi-Yuan Wang and Xi Yan and Chong-Yu Wang and Yi-Xin Zhang and Zhen-Hua Ge and Jing Feng}, doi = {10.1002/advs.202409494}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2409494}, shortjournal = {Adv. Sci.}, title = {Excellent thermoelectric performance realized in copper sulfide magnetic nanocomposites via modified solid states reaction}, volume = {12}, year = {2025}, }
• (2025). Cell-type specific circuits in the mammillary body for place and object recognition memory. ADVS, 12(13), 2409397. (www)

  @article{ , abstract = {Mammillary body (MB) is traditionally viewed as a structural node of an anatomic circuit for emotion and memory. However, little is known about its molecular and cellular organizations. Here, a discovery that MB contains four subtypes of neurons that occupy different spatial subregions is reported. Of these, two subtypes of neurons are tagged by parvalbumin (PV) and dopamine receptor-D2 (Drd2) markers. PV neurons are spontaneously active, whereas Drd2 neurons are inactive at rest and generate rebound bursts. These two distinct electrophysiological properties are encoded by Kcnn4 and Cacna1h . PV and Drd2 neurons generate two distinct cell-type specific circuits by receiving inputs from two discrete subiculum neuronal classes. Gain- and loss-of-function studies on these cortical-subcortical circuits demonstrate their differential roles for place and object recognition memory. This finding provides a comprehensive molecular and structural atlas of MB neurons at single-cell resolution and reveals that MB contains molecularly, structurally, and functionally dissociable streams within its serial architecture.}, archive = {J_ADVS}, author = {Lanfang Li and Yiqing Guo and Wei Jing and Xiaomei Tang and Jinyu Zeng and Zhenye Hou and Yige Song and Aodi He and Hao Li and Ling-Qiang Zhu and Youming Lu and Xinyan Li}, doi = {10.1002/advs.202409397}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2409397}, shortjournal = {Adv. Sci.}, title = {Cell-type specific circuits in the mammillary body for place and object recognition memory}, volume = {12}, year = {2025}, }
• (2025). Vitamin C-dependent intergenerational inheritance of enhanced endurance performance following maternal exercise. ADVS, 12(13), 2408912. (www)

  @article{ , abstract = {Declining levels of physical activity and fitness in children and youth are linked to negative health outcomes. This study investigates whether maternal exercise can enhance offspring's physical fitness. Our results demonstrate that maternal exercise improves offspring's endurance by changing muscle fiber composition and promoting mitochondrial biogenesis, with benefits lasting across generations. This improvement is associated with changes in DNA methylation, specifically the demethylation of the Slc23a2 gene, which codes for SVCT2, crucial for vitamin C (VC) transport, in F1 and F2 generations. Importantly, VC administration during pregnancy mimics the transgenerational benefits of exercise on offspring fitness, but these benefits are absent in genetic VC deficiency mice. VC supplementation increases TET2 expression in murine and human myogenic cells, regulating DNA methylation, promoting the development of oxidative fibers, and enhancing mitochondrial biogenesis. This study highlights the VC-TET2-SVCT2 pathway as a key mechanism for the transgenerational endurance benefits of maternal exercise, suggesting potential strategies to enhance maternal and child health.}, archive = {J_ADVS}, author = {Haiwang Shi and Jie Li and Fan Li and Haoyang Yu and Fulong Zhang and Tao Wu and Luodan Yang and Yuecheng Li and Rui Hu and Mengjie Chen and Nina SG and Xuhong Zhuang and Shu Feng and Ling Zhu and Rui Duan}, doi = {10.1002/advs.202408912}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2408912}, shortjournal = {Adv. Sci.}, title = {Vitamin C-dependent intergenerational inheritance of enhanced endurance performance following maternal exercise}, volume = {12}, year = {2025}, }
• (2025). Deletion of pyruvate carboxylase in tubular epithelial cell promotes renal fibrosis by regulating SQOR/cGAS/STING-mediated glycolysis. ADVS, 12(13), 2408753. (www)

  @article{ , abstract = {Renal fibrosis is a common pathway involved in the progression of various chronic kidney diseases to end-stage renal disease. Recent studies show that mitochondrial injury of renal tubular epithelial cells (RTECs) is a crucial pathological foundation for renal fibrosis. However, the underlying regulatory mechanisms remain unclear. Pyruvate carboxylase (PC) is a catalytic enzyme located within the mitochondria that is intricately linked with mitochondrial damage and metabolism. In the present study, the downregulation of PC in various fibrotic animal and human kidney samples is demonstrated. Renal proximal tubule–specific Pcx gene knockout mice ( Pcx cKO ) has significant interstitial fibrosis compared to control mice, with heightened expression of extracellular matrix molecules. This is further demonstrated in a stable PC knock-out RTEC line. Mechanistically, PC deficiency reduces its interaction with sulfide:quinone oxidoreductase (SQOR), increasing the ubiquitination and degradation of SQOR. This leads to mitochondrial morphological and functional disruption, increased mtDNA release, activation of the cGAS-STING pathway, and elevated glycolysis levels, and ultimately, promotes renal fibrosis. This study investigates the molecular mechanisms through which PC deficiency induces mitochondrial injury and metabolic reprogramming in RTECs. This study provides a novel theoretical foundation and potential therapeutic targets for the pathogenesis and treatment of renal fibrosis.}, archive = {J_ADVS}, author = {Hao Huang and Yuanyuan Han and Yan Zhang and Jianhua Zeng and Xin He and Jiawei Cheng and Songkai Wang and Yiwei Xiong and Hongling Yin and Qiongjing Yuan and Ling Huang and Yanyun Xie and Jie Meng and Lijian Tao and Zhangzhe Peng}, doi = {10.1002/advs.202408753}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2408753}, shortjournal = {Adv. Sci.}, title = {Deletion of pyruvate carboxylase in tubular epithelial cell promotes renal fibrosis by regulating SQOR/cGAS/STING-mediated glycolysis}, volume = {12}, year = {2025}, }
• (2025). Single-cell transcriptomes of immune cells from multiple compartments redefine the ontology of myeloid subtypes post-stroke. ADVS, 12(13), 2408722. (www)

  @article{ , abstract = {The activation and infiltration of immune cells are hallmarks of ischemic stroke. However, the precise origins and the molecular alterations of these infiltrating cells post-stroke remain poorly characterized. Here, a murine model of stroke (permanent middle cerebral artery occlusion [p-MCAO]) is utilized to profile single-cell transcriptomes of immune cells in the brain and their potential origins, including the calvarial bone marrow (CBM), femur bone marrow (FBM), and peripheral blood mononuclear cells (PBMCs). This analysis reveals transcriptomically distinct populations of cerebral myeloid cells and brain-resident immune cells after stroke. These include a novel CD14 + neutrophil subpopulation that transcriptomically resembles CBM neutrophils. Moreover, the sequential activation of transcription factor regulatory networks in neutrophils during stroke progression is delineated, many of which are unique to the CD14 + population and underlie their acquisition of chemotaxis and granule release capacities. Two distinct origins of post-stroke disease-related immune cell subtypes are also identified: disease inflammatory macrophages, likely deriving from circulating monocytes in the skull, and transcriptionally immature disease-associated microglia, possibly arising from pre-existing homeostatic microglia. Together, a comprehensive molecular survey of post-stroke immune responses is performed, encompassing both local and distant bone marrow sites and peripheral blood.}, archive = {J_ADVS}, author = {Mo Yang and Yixiang Li and Kaibin Shi and Xuezhu Wang and Xiangrong Liu and Xiang Huang and Fu-Dong Shi and Shaojie Ma and Mingfeng Li and Yilong Wang}, doi = {10.1002/advs.202408722}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2408722}, shortjournal = {Adv. Sci.}, title = {Single-cell transcriptomes of immune cells from multiple compartments redefine the ontology of myeloid subtypes post-stroke}, volume = {12}, year = {2025}, }
• (2025). Brightened optical transition hinting to strong spin-lattice coupling in a layered antiferromagnet. ADVS, 12(13), 2408343. (www)

  @article{ , abstract = {Two-dimensional (2D) van der Waals magnets show strong interconnection between their electrical, magnetic, and structural properties. Here, the emergence of a luminescent transition is revealed upon crossing the Néel transition temperature of CrPS 4 , a layered antiferromagnetic semiconductor. This luminescent transition occurs above the lowest absorption level. The optical transitions are attributed to excited states of the t 2g orbitals of the Cr 3+ ions, which are influenced by the distortion of the octahedral crystal field. Specifically, the vicinity of the Néel temperature, the distortion switches from an anti-polar to a polar arrangement, thereby not only promoting an additional luminescent pathway but also significantly strengthening the static dipole moment detected by a marked enhancement in the intensity of the second harmonic generation. These results strongly encourage further investigation into the multiferroic properties and potential coupling mechanisms in CrPS 4 .}, archive = {J_ADVS}, author = {Volodymyr Multian and Fan Wu and Dirk van der Marel and Nicolas Ubrig and Jérémie Teyssier}, doi = {10.1002/advs.202408343}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2408343}, shortjournal = {Adv. Sci.}, title = {Brightened optical transition hinting to strong spin-lattice coupling in a layered antiferromagnet}, volume = {12}, year = {2025}, }
• (2025). Tracing the evolution of sex hormones and receptor-mediated immune microenvironmental differences in prostate and bladder cancers: From embryonic development to disease. ADVS, 12(13), 2407715. (www)

  @article{ , abstract = {The bladder and prostate originate from the urogenital sinus. However, bladder cancer (BC) is usually classified as an immune “hot” tumor, whereas prostate cancer (PCa) is deemed as an immune “cold” tumor according to the tumor microenvironment (TME) and clinical outcomes. To investigate the immune differences between BC and PCa, studies are compared focusing on immune regulation mediated by sex hormones and receptors to identify key genes and pathways responsible for the immune differences. From a developmental perspective, it is shown that PCa and BC activate genes and pathways similar to those in the developmental stage. During prostate development, the differential expression and function of the androgen receptor (AR) across cell types may contribute to its dual role in promoting and inhibiting immunity in different cells. Androgen deprivation therapy affects AR function in different cells within the TME, influencing immune cell infiltration and antitumor function. Additionally, estrogenα and estrogenβ exert contrasting effects in PCa and BC, which may hold the potential for modifying the “cold” and “hot” tumor phenotypes. Future research should target key genes and pathways involved in bladder development to clarify the immune regulatory similarities and differences between BC and PCa.}, archive = {J_ADVS}, author = {Dengxiong Li and Zhipeng Wang and Qingxin Yu and Jie Wang and Ruicheng Wu and Zhouting Tuo and Koo Han Yoo and Dilinaer Wusiman and Luxia Ye and Yiqing Guo and Yubo Yang and Fanglin Shao and Ziyu Shu and Uzoamaka Okoli and William C. Cho and Wuran Wei and Dechao Feng}, doi = {10.1002/advs.202407715}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2407715}, shortjournal = {Adv. Sci.}, title = {Tracing the evolution of sex hormones and receptor-mediated immune microenvironmental differences in prostate and bladder cancers: From embryonic development to disease}, volume = {12}, year = {2025}, }
• (2025). CircSATB1 promotes colorectal cancer liver metastasis through facilitating FKBP8 degradation via RNF25-mediated ubiquitination. ADVS, 12(13), 2406962. (www)

  @article{ , abstract = {Colorectal cancer (CRC) is one of the most common cancers worldwide and liver metastasis is the leading reason for its mortality. Circular RNAs (circRNAs) are conclusively associated with the progression of various cancers, rendering the exploration of its specific mechanisms in colorectal cancer liver metastasis(CRLM) highly valuable. Combined with GEO (Gene Expression Omnibus) databases and clinical data in our center, we found that high expression of circSATB1 is closely related to the progression of CRLM. Functionally, circSATB1 could significantly promote the metastatic ability of CRC cells in vitro and in vivo. Mechanistically, circSATB1 facilitated the RNF25-mediated ubiquitylation and degradation of FKBP8, releasing its inhibitory effects on mTOR signaling. In this process, circSATB1 acted as a scaffold for RNF25-FKBP8 complexes. Additionally, circSATB1 could be packaged in exosomes and secreted from the CRC primary tumors into plasma. In conclusion, this study uncovered a new circSATB1 that acts as a potent promoter of CRLM and offers novel insights into the precision therapeutic strategies for CRLM.}, archive = {J_ADVS}, author = {Chuan Zhang and Chuanxin Tian and Renzhong Zhu and Chen Chen and Chi Jin and Xiaowei Wang and Lejia Sun and Wen Peng and Dongjian Ji and Yue Zhang and Yueming Sun}, doi = {10.1002/advs.202406962}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2406962}, shortjournal = {Adv. Sci.}, title = {CircSATB1 promotes colorectal cancer liver metastasis through facilitating FKBP8 degradation via RNF25-mediated ubiquitination}, volume = {12}, year = {2025}, }
• (2025). Multi-omics analysis reveals impacts of LincRNA deletion on yeast protein synthesis. ADVS, 12(13), 2406873. (www)

  @article{ , abstract = {Non-coding RNAs (ncRNAs) are widespread across various genomic regions and play a crucial role in modulating gene expression and cellular functions, thereby increasing biological complexity. However, the relationship between ncRNAs and the production of heterologous recombinant proteins (HRPs) remains elusive. Here, a yeast library is constructed by deleting long intergenic ncRNAs (lincRNAs), and 21 lincRNAs that affect α-amylase secretion are identified. Targeted deletions of SUT067, SUT433, and CUT782 are found to be particularly effective. Transcriptomic and metabolomic analyses of the top three strains indicate improvements in energy metabolism and cytoplasmic translation, which enhances ATP supply and protein synthesis. Moreover, a yeast strain, derived from the SUT433 deletion, that can secrete ≈4.1 g L⁻ 1 of α-amylase in fed-batch cultivation through the modification of multiple targets, is engineered. This study highlights the significant potential of lincRNAs in modulating cellular metabolism, providing deep insights and strategies for the development of more efficient protein-producing cell factories.}, archive = {J_ADVS}, author = {Ling Qin and Yuyang Pan and Songlyu Xue and Zhibo Yan and Chufan Xiao and Xiufang Liu and Dan Yuan and Jin Hou and Mingtao Huang}, doi = {10.1002/advs.202406873}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2406873}, shortjournal = {Adv. Sci.}, title = {Multi-omics analysis reveals impacts of LincRNA deletion on yeast protein synthesis}, volume = {12}, year = {2025}, }
• (2025). Comment on: “Atom-modified gDNA enhances cleavage activity of TtAgo enabling ultrasensitive nucleic acid testing”. ADVS, 12(13), 2406872. (www)

  @article{ , abstract = {The recent article by Zhang et al. piqued the interest. An atom-modification-based strategy is reported to enhance the cleavage activity of TtAgo, improving its practicability in TtAgo-based nucleic acid testing. Specifically, the 2′-fluorine (2′F)-modified guide DNA (2′F-gDNA) shows significant enhancement in the cleavage activity of TtAgo on double-stranded (dsDNA) by increasing the melting temperature (Tm) and strengthening the binding affinity between 2′F-gDNA and the targeted dsDNA. These findings are considered important for both molecular diagnostics and gene editing. A careful review of the article, however, raises questions that merit further discussion. After comprehensively reviewing the cleavage mechanism and structure of TtAgo-gDNA-target ternary complexes, and thoroughly analyzing our results, it is believed that the increased Tm and binding affinity of 2′F-gDNA are not the primary factors that enhance cleavage activity, it is speculated that the 2′F modification at gDNA 3′-end likely influences the propagation step. The data suggest that several details need to be addressed to improve the robustness of 2′F-gDNA/TtAgo cleavage.}, archive = {J_ADVS}, author = {Yue Tang and Xiao-han Wang and Xu Xu and Lu-sheng Xin and Xiu-dan Wang and Xin-min Li}, doi = {10.1002/advs.202406872}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2406872}, shortjournal = {Adv. Sci.}, title = {Comment on: “Atom-modified gDNA enhances cleavage activity of TtAgo enabling ultrasensitive nucleic acid testing”}, volume = {12}, year = {2025}, }
• (2025). Essential role of the anterior piriform cortex in mediating social novelty output via a Top–Down circuit. ADVS, 12(13), 2406192. (www)

  @article{ , abstract = {Social novelty is indispensable for a wide range of social behaviors. The medial prefrontal cortex (mPFC), along with other social information hubs, composes the foundational circuitry of social novelty. However, the precise circuit mechanisms that govern social novelty processing remain elusive. The piriform cortex, as the largest olfactory cortex, receives extensive innervation from top-down centers that dictate social behavior. Here, it is shown that the anterior piriform cortex (APC) exhibited an increase in gamma event incidence during social engagement in male mice. In vivo electrophysiology and fiber photometry reveal that APC pyramidal neurons respond more intensely to novel mice than familiar ones. Intriguingly, silencing APC neurons selectively impairs social novelty processing, yet leaves the basic olfactory discrimination capabilities intact. Moreover, the APC inherits social cues from the mPFC and sends feedback projections to the olfactory bulb (OB) to modulate social novelty. These findings unveil the APC's role as extending well beyond olfaction, encompassing a specialized function in social novelty recognition in male mice.}, archive = {J_ADVS}, author = {Jingwei Zhou and Zhaoyang Yin and Zhiyun Chen and Hanyu Fu and Qun Li and Shan Li and Ying Zhang and Xianzhi Zhang and Dewei Tang and Anan Li and Dejuan Wang}, doi = {10.1002/advs.202406192}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2406192}, shortjournal = {Adv. Sci.}, title = {Essential role of the anterior piriform cortex in mediating social novelty output via a Top–Down circuit}, volume = {12}, year = {2025}, }
• (2025). High-speed embedded ink writing of anatomic-size organ constructs. ADVS, 12(13), 2405980. (www)

  @article{ , abstract = {Embedded ink writing (EIW) is an emerging 3D printing technique that fabricates complex 3D structures from various biomaterial inks but is limited to a printing speed of ∼10 mm s −1 due to suboptimal rheological properties of particulate-dominated yield-stress fluids when used as liquid baths. In this work, a particle-hydrogel interactive system to design advanced baths with enhanced yield stress and extended thixotropic response time for realizing high-speed EIW is developed. In this system, the interactions between particle additive and three representative polymeric hydrogels enable the resulting nanocomposites to demonstrate different rheological behaviors. Accordingly, the interaction models for the nanocomposites are established, which are subsequently validated by macroscale rheological measurements and advanced microstructure characterization techniques. Filament formation mechanisms in the particle-hydrogel interactive baths are comprehensively investigated at high printing speeds. To demonstrate the effectiveness of the proposed high-speed EIW method, an anatomic-size human kidney construct is successfully printed at 110 mm s −1 , which only takes ∼4 h. This work breaks the printing speed barrier in current EIW and propels the maximum printing speed by at least 10 times, providing an efficient and promising solution for organ reconstruction in the future.}, archive = {J_ADVS}, author = {Weijian Hua and Cheng Zhang and Haoran Cui and Kellen Mitchell and Dale K. Hensley and Jihua Chen and Changwoo Do and Lily Raymond and Ryan Coulter and Erick Bandala and Fazlay Rubbi and Guangrui Chai and Zhengyi Zhang and Yiliang Liao and Danyang Zhao and Yan Wang and Akhilesh K. Gaharwar and Yifei Jin}, doi = {10.1002/advs.202405980}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2405980}, shortjournal = {Adv. Sci.}, title = {High-speed embedded ink writing of anatomic-size organ constructs}, volume = {12}, year = {2025}, }
• (2025). Ribonuclease 1 induces T-cell dysfunction and impairs CD8+ T-cell cytotoxicity to benefit tumor growth through hijacking STAT1. ADVS, 12(13), 2404961. (www)

  @article{ , abstract = {T-cell-based immunotherapy holds promise for eliminating cancer through T-cell activation. However, prolonged interaction between T cells and tumors and the presence of immunosuppressive factors can diminish T-cell cytotoxicity, leading to treatment failure. Here, ribonuclease 1 (RNase1), which degrades RNA, reduced the expression of effector cytokines and increases immune checkpoint protein levels, inducing T-cell dysfunction. RNase1 expression is positively associated with exhausted T-cell gene signatures and immune checkpoint proteins across several cancer types. Cancer cells expressing RNase1 are resistant to CD8 + T-cell-mediated killing. RNase1 promotes tumor growth in immunocompetent, but not in immunodeficient, mouse models and inhibits CD8 + T-cell activity in vivo. Mechanistically, RNase1 enters T cells and deactivates signal transducer and activator of transcription 1 (STAT1), causing T-cell dysfunction. Loss of RNase1-STAT1 interaction restores CD8 + T-cell cytotoxicity. Notably, a study has found RNase1 might activate CD4 + T cells to inhibit breast cancer growth, while another has indicated it causes immunosuppression in liver cancer. The current research shows that RNase1 does not impact CD4 + T cells in vivo. Overall, the study supports the immunosuppressive role of RNase1 in cancer of negatively regulating STAT1 to impair CD8 + T-cell cytotoxicity. Targeting the RNase1-STAT1 interaction could prevent CD8 + T-cell dysfunction in RNase1-highly expressing cancer patients.}, archive = {J_ADVS}, author = {Wen-Hao Yang and Bao-Yue Huang and Hsing-Yu Rao and Peng Ye and Bi Chen and Hao-Ching Wang and Chih-Hung Chung and Heng-Hsiung Wu and Hung-Rong Yen and Shao-Chun Wang and Jong-Ho Cha and Xiuwen Yan and Muh-Hwa Yang and Mien-Chie Hung}, doi = {10.1002/advs.202404961}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2404961}, shortjournal = {Adv. Sci.}, title = {Ribonuclease 1 induces T-cell dysfunction and impairs CD8+ T-cell cytotoxicity to benefit tumor growth through hijacking STAT1}, volume = {12}, year = {2025}, }
• (2025). Unraveling the mechanisms of lithium-alloy plating in Ag–C anode: In situ SEM study. ADVS, 12(13), 2404840. (www)

  @article{ , abstract = {The Ag–C composite anodes facilitate stable Li x Ag deposition in solid-state batteries. However, the role of carbon and the kinetics of lithium migration and deposition in the composite structure remain unclear. Few studies have focused on this critical research area owing to a shortage of effective, non-destructive characterization methods that can directly observe the Li alloy deposition process in solid-state batteries in real time. In this study, Li alloy formation on the Ag–C anode is investigated through operando X-ray diffraction (XRD) analysis and scanning electron microscopy combined with in situ probing. This enables the observation of the composition and morphology of the Li x Ag alloy as it evolves within the Ag–C composite anode during discharge. Further insights from scanning transmission electron microscopy–electron energy loss spectroscopy and first-principles simulations on lithiophilicity and the energy barrier for lithium migration reveal a complex lithium migration and deposition mechanism within the Ag–C anode.}, archive = {J_ADVS}, author = {Y. Kamikawa}, doi = {10.1002/advs.202404840}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2404840}, shortjournal = {Adv. Sci.}, title = {Unraveling the mechanisms of lithium-alloy plating in Ag–C anode: In situ SEM study}, volume = {12}, year = {2025}, }
• (2025). The FBXW7-RPAP2 axis controls the growth of hepatocellular carcinoma cells and determines the fate of liver cell differentiation. ADVS, 12(13), 2404718. (www)

  @article{ , abstract = {RNA polymerase II-associated protein 2 (RPAP2) plays a critical role in transcriptional regulation. However, little is known about whether and how RPAP2 regulates hepatocellular carcinoma (HCC) cell growth, and how the RPAP2 stability is precisely maintained. Here it is reported that high RPAP2 levels in HCC tissues correlate with poor patient survival. RPAP2 depletion suppresses the growth and survival of HCC cells. F-box and WD repeat domain-containing 7 (FBXW7) targets RPAP2 for polyubiquitylation and degradation after RPAP2 being pre-phosphorylated at Ser562 and Thr565 by p38 and GSK3, respectively. HSP90 inhibition significantly promotes RPAP2 degradation by CRL5 FBXW7 ligase, whereas USP7 deubiquitylates and stabilizes RPAP2. FBXW7 knockdown promotes HCC cell growth via RPAP2 accumulation in vitro and in vivo. In mice, the hepatic-specific deletion of Fbxw7 leads to hepatic cystogenesis with consequential accumulation of RPAP2. Simultaneous deletion of Rpap2 completely reverses the hepatic cystogenesis, indicating a causal role of RPAP2. Taken together, this study demonstrates that the RPAP2 stability is negatively regulated by FBXW7, but positively regulated by HSP90 and USP7. The FBXW7-RPAP2 axis regulates HCC cell growth and modulates the fate of liver cell differentiation. These findings provide proof-of-concept evidence that oncogenic RPAP2 could be a promising therapeutic target for HCC.}, archive = {J_ADVS}, author = {Danrui Cui and Shengpeng Shao and Ruirui Qu and Xiaoyu Chen and Shanghong Jiang and Linchen Wang and Longyuan Gong and Tianqi Li and Danyi Zhai and Wenfeng Song and Penghong Song and Yi Sun and Tingbo Liang and Xiufang Xiong and Yongchao Zhao}, doi = {10.1002/advs.202404718}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2404718}, shortjournal = {Adv. Sci.}, title = {The FBXW7-RPAP2 axis controls the growth of hepatocellular carcinoma cells and determines the fate of liver cell differentiation}, volume = {12}, year = {2025}, }
• (2025). D2HGDH deficiency regulates seizures through GSH/Prdx6/ROS-mediated excitatory synaptic activity. ADVS, 12(13), 2404488. (www)

  @article{ , abstract = {Current antiepileptic drugs are ineffective in one-third of patients with epilepsy; however, identification of genes involved in epilepsy can enable a precision medicine approach. Here, it is demonstrated that downregulating D-2-hydroxyglutarate dehydrogenase ( D2HGDH ) enhances susceptibility to epilepsy. Furthermore, its potential involvement in the seizure network through synaptic function modulation is investigated. D2HGDH knockdown reduces the glutathione reduced (GSH)/glutathione oxidized (GSSG) ratio and elevates reactive oxygen species (ROS) levels within neurons. Oxidative stress may play a crucial role in the pathogenesis of epilepsy. The specific contribution of each pathway varies among patients, highlighting the complexity of this disease. In this study, downregulation of D2HGDH affects modulation of ROS levels, synaptic transmission, and seizure susceptibility. Furthermore, the acid calcium-independent phospholipase A2 (aiPLA2) inhibitor, MJ33, restores the GSH/GSSG balance and reverses the increase in ROS levels caused by D2HGDH knockdown, resulting in remission of epilepsy-related behaviors. The results demonstrate that downregulation of D2HGDH affects synaptic function by regulating ROS production. These findings support the use of targeted gene therapy as a potential alternative to antioxidant-based treatments for refractory epilepsy.}, archive = {J_ADVS}, author = {Zhijuan Zhang and Hui Zhang and Peng Zhang and Rong Li and Jinyu Zhou and Jiyuan Li and Danmei Hu and Rui Huang and Fenglin Tang and Jie Liu and Demei Xu and Chenlu Zhang and Xin Tian and Yuanlin Ma and Patrick Kwan}, doi = {10.1002/advs.202404488}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2404488}, shortjournal = {Adv. Sci.}, title = {D2HGDH deficiency regulates seizures through GSH/Prdx6/ROS-mediated excitatory synaptic activity}, volume = {12}, year = {2025}, }
• (2025). Effectiveness and safety of oral azvudine for elderly hospitalized patients with COVID-19: A multicenter, retrospective, real-world study. ADVS, 12(13), 2404450. (www)

  @article{ , abstract = {Azvudine is recommended as a priority treatment for patients with Coronavirus Disease 2019 (COVID-19) during Omicron wave in China, but its efficacy and safety in elderly patients is unknown. In this multicenter, retrospective study, we identified 19763 elderly patients (aged over 60 years) with COVID-19 from nine hospitals in Henan Province, China. The primary outcome is all-cause death and the secondary outcome is composite disease progression. After propensity score matching, 4109 Azvudine recipients and 4109 matched controls is included, with average age of 75.15 years. Kaplan–Meier analysis reveales a notably survival and progression-free benefit in Azvudine treatment. The Cox analysis shows that compared with controls, Azvudine recipients have a 33% lower risk of all-cause death (95% confidence Interval (CI): 0.580–0.772, p < 0.001), but have no significant difference in composite disease progression (hazard ratio: 0.93, 95% CI: 0.833-1.046, p = 0.234). Subgroup analysis suggested Azvudine have a stronger protective effect in patients concomitant with antibiotics. Three sensitive analyses confirm the robustness of the findings. The safety of Azvudine in elderly patients is acceptable. These findings indicate that Azvudine therapy can reduce the rate of all-cause death in hospitalized elderly patients with COVID-19, and without obvious adverse events.}, archive = {J_ADVS}, author = {Ranran Sun and Haiyu Wang and Junyi Sun and Mengzhao Yang and Shixi Zhang and Xinjun Hu and Bo Yu and Zhan Song and Na Han and Hong Luo and Ming Cheng and Guangming Li and Guotao Li and Yiqiang Yuan and Lili Liang and Yanyang Zhang and Donghua Zhang and Silin Li and Quancheng Kan and Hongxia Liang and Zhigang Ren}, doi = {10.1002/advs.202404450}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2404450}, shortjournal = {Adv. Sci.}, title = {Effectiveness and safety of oral azvudine for elderly hospitalized patients with COVID-19: A multicenter, retrospective, real-world study}, volume = {12}, year = {2025}, }
• (2025). PJA2 suppresses colorectal cancer progression by controlling HDAC2 degradation and stability. ADVS, 12(13), 2401964. (www)

  @article{ , abstract = {PJA2 is documented to degrade various substrates. Nevertheless, the role of PJA2 as an E3 ubiquitin-protein ligase in colorectal cancer (CRC) progression remains unexplored. The correlation between PJA2 mRNA levels and clinical characteristics is investigated using data from The Cancer Genome Atlas (TCGA) database. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) are utilized to evaluate PJA2 expression levels in CRC tissues. The biological functions of PJA2 are confirmed through colony formation assays and azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model of CRC, among other experimental approaches. The underlying molecular mechanisms of PJA2 action are elucidated using RNA sequencing (RNA-seq), co-immunoprecipitation (co-IP), proximity ligation assay (PLA), and chromatin immunoprecipitation (ChIP). Our research discovered that PJA2 is downregulated in CRC tissues and decreased PJA2 expression correlates with poor prognosis. Functionally, in vivo and in vitro experiments uncovered that PJA2 inhibits tumor cell proliferation and promotes apoptosis. Mechanistically, PJA2 recognized histone deacetylase 2 (HDAC2) via its RING-B-box domain (RBD) and bind to the N-terminal of HDAC2, facilitating ubiquitination at the lysine 90 (K90) residue. PJA2-mediated degradation of HDAC2 counteracts the transcriptional repression of the interferon-induced protein with the tetratricopeptide repeats (IFIT) family, thereby suppressing CRC progression. The data demonstrates that PJA2 suppresses CRC progression through the PJA2/HDAC2/IFIT axis, and its expression is regulated by HDAC2, thus constituting a positive feedback loop. Consequently, PJA2 may serve as a potential therapeutic target for CRC, and interrupting this feedback loop can represent a viable treatment strategy to restrain CRC progression.}, archive = {J_ADVS}, author = {Zhihao Chen and Chaofan Peng and Chi Jin and Ye Wang and Tuo Wang and Peng Yang and Wen Peng and Qingyang Sun and Hengjie Xu and Hongxu Nie and Xiaowei Wang and Junwei Tang and Yueming Sun and Yifei Feng}, doi = {10.1002/advs.202401964}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2401964}, shortjournal = {Adv. Sci.}, title = {PJA2 suppresses colorectal cancer progression by controlling HDAC2 degradation and stability}, volume = {12}, year = {2025}, }
• (2025). A gallbladder-specific hydrophobic bile acid-FXR-MUC1 signaling axis mediates cholesterol gallstone formation. ADVS, 12(13), 2401956. (www)

  @article{ , abstract = {Differences in the distribution of hydrophilic and hydrophobic bile acids (BA) are observed in mouse models of non-alcoholic fatty liver disease (NAFLD) induced by a high-fat-cholesterol “Western-style” diet (WD), and cholesterol gallstone disease (CGD) induced by a lithogenic diet. Despite sharing common pathological processes, these models exhibit distinct characteristics in their BA pools. The study investigates the impact of hydrophobic BA ( Hpho BA) and hydrophilic BA ( Hphil BA) on CGD development using cytochrome-P450-2c70 knockout (C70-KO) mice (mice C70-KO ), genetically modified to resemble humans with a hydrophobic BA pool. All mice C70-KO fed the WD develop CGD, resembling human cholelithiasis patients, while WD-fed wild-type (WT) mice (mice WT ) show cholesterol-saturated bile but rarely form gallstones. Compared to mice WT , WD-fed mice C70-KO display caveolae microdomain redistribution in the gallbladder mediated by the Hpho BA, FXR, and miR30c/e axis, which enhances the Sp1 transcriptional activity of mucin-1 ( MUC1 ) genes through nuclear translocation of protein kinase Cζ (PKCζ). These changes contribute to increased production of pronucleating agents (MUC1 and MUC5ac) and accelerate crystallization of gallbladder cholesterol. The data also suggest that WD-fed mice C70-KO appropriately model human CGD since lithogenic diet-fed mice WT have a larger BA pool that masks the negative effects of gallbladder FXR on CGD development.}, archive = {J_ADVS}, author = {Hongtan Chen and Xin Jiang and Yiqiao Li and Honggang Guo and Jianguo Wu and Sha Li and Fengling Hu and Guoqiang Xu}, doi = {10.1002/advs.202401956}, journal = {Advanced Science}, month = {4}, number = {13}, pages = {2401956}, shortjournal = {Adv. Sci.}, title = {A gallbladder-specific hydrophobic bile acid-FXR-MUC1 signaling axis mediates cholesterol gallstone formation}, volume = {12}, year = {2025}, }
• (2025). Aging-induced alternation in the gut microbiota impairs host antibacterial defense (Adv. sci. 12/2025). ADVS, 12(12), 2570084. (www)

  @article{ , archive = {J_ADVS}, author = {Peng Gu and Rongjuan Wei and Ruofan Liu and Qin Yang and Yuxuan He and Jianbin Guan and Wenhao He and Jiaxin Li and Yunfei Zhao and Li Xie and Jie He and Qingling Guo and Jiajia Hu and Jingna Bao and Wandang Wang and Jiayin Guo and Zhenhua Zeng and Zhongqing Chen and Yong Jiang and Zhanguo Liu and Peng Chen}, doi = {10.1002/advs.202570084}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2570084}, shortjournal = {Adv. Sci.}, title = {Aging-induced alternation in the gut microbiota impairs host antibacterial defense (Adv. sci. 12/2025)}, volume = {12}, year = {2025}, }
• (2025). Thermally triggered double emulsion-integrated hydrogel microparticles for multiplexed molecular diagnostics (Adv. sci. 12/2025). ADVS, 12(12), 2570083. (www)

  @article{ , archive = {J_ADVS}, author = {Eui Ju Jeon and Seungwon Jung and Yoon-ha Jang and Seoyoung Lee and Song-Ee Choi and So Young Jeon and Lankyeong Yoon and Bong Kyun Kim and Tae Jong Kim and Kuenyoul Park and Seok Chung and Yong Shin and Sung-Han Kim and Heungsup Sung and Sang Kyung Kim}, doi = {10.1002/advs.202570083}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2570083}, shortjournal = {Adv. Sci.}, title = {Thermally triggered double emulsion-integrated hydrogel microparticles for multiplexed molecular diagnostics (Adv. sci. 12/2025)}, volume = {12}, year = {2025}, }
• (2025). Design principles from natural olfaction for electronic noses (Adv. sci. 12/2025). ADVS, 12(12), 2570082. (www)

  @article{ , archive = {J_ADVS}, author = {Haritosh Patel and Vicente Garrido Portilla and Anna V. Shneidman and Jacopo Movilli and Jack Alvarenga and Christophe Dupré and Michael Aizenberg and Venkatesh N. Murthy and Alexander Tropsha and Joanna Aizenberg}, doi = {10.1002/advs.202570082}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2570082}, shortjournal = {Adv. Sci.}, title = {Design principles from natural olfaction for electronic noses (Adv. sci. 12/2025)}, volume = {12}, year = {2025}, }
• (2025). Deep learning-based ion channel kinetics analysis for automated patch clamp recording (Adv. sci. 12/2025). ADVS, 12(12), 2570080. (www)

  @article{ , archive = {J_ADVS}, author = {Shengjie Yang and Jiaqi Xue and Ziqi Li and Shiqing Zhang and Zhang Zhang and Zhifeng Huang and Ken Kin Lam Yung and King Wai Chiu Lai}, doi = {10.1002/advs.202570080}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2570080}, shortjournal = {Adv. Sci.}, title = {Deep learning-based ion channel kinetics analysis for automated patch clamp recording (Adv. sci. 12/2025)}, volume = {12}, year = {2025}, }
• (2025). Targeted delivery of c(RGDfk)-modified liposomes to bone marrow through in vivo hitchhiking neutrophils for multiple myeloma therapy (Adv. sci. 12/2025). ADVS, 12(12), 2570079. (www)

  @article{ , archive = {J_ADVS}, author = {Huiwen Liu and Bo Zhang and Hongrui Chen and Honglan Wang and Xifeng Qin and Chunyan Sun and Zhiqing Pang and Yu Hu}, doi = {10.1002/advs.202570079}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2570079}, shortjournal = {Adv. Sci.}, title = {Targeted delivery of c(RGDfk)-modified liposomes to bone marrow through in vivo hitchhiking neutrophils for multiple myeloma therapy (Adv. sci. 12/2025)}, volume = {12}, year = {2025}, }
• (2025). Electropositive magnetic fluorescent nanoprobe-mediated immunochromatographic assay for the ultrasensitive and simultaneous detection of bacteria (Adv. sci. 12/2025). ADVS, 12(12), 2570078. (www)

  @article{ , archive = {J_ADVS}, author = {Jiaxuan Li and Zhengkang Li and Bingjie Wang and Qing Yu and Ting Wu and Chongwen Wang and Bing Gu}, doi = {10.1002/advs.202570078}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2570078}, shortjournal = {Adv. Sci.}, title = {Electropositive magnetic fluorescent nanoprobe-mediated immunochromatographic assay for the ultrasensitive and simultaneous detection of bacteria (Adv. sci. 12/2025)}, volume = {12}, year = {2025}, }
• (2025). A novel protein NLRP12-119aa that prevents rhabdovirus replication by disrupting the RNP complex formation (Adv. sci. 12/2025). ADVS, 12(12), 2570077. (www)

  @article{ , archive = {J_ADVS}, author = {Weiwei Zheng and Xiangxiang Zhu and Tongtong Zhu and Qiang Luo and Yan Zhao and Tianjun Xu}, doi = {10.1002/advs.202570077}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2570077}, shortjournal = {Adv. Sci.}, title = {A novel protein NLRP12-119aa that prevents rhabdovirus replication by disrupting the RNP complex formation (Adv. sci. 12/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “A multifunctional cobalt-containing implant for treating biofilm infections and promoting osteointegration in infected bone defects through macrophage-mediated immunomodulation”. ADVS, 12(12), 2502472. (www)

  @article{ , archive = {J_ADVS}, author = {Nongyang Yan and Hao Zhou and Jinpeng He and Tengfei Li and Qi Liu and Hao Ning and Zhixin Ma and Linfei Feng and Tao Jin and Youwen Deng and Zhengwei Wu and Shauna Celeste Kennard}, doi = {10.1002/advs.202502472}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2502472}, shortjournal = {Adv. Sci.}, title = {Correction to “A multifunctional cobalt-containing implant for treating biofilm infections and promoting osteointegration in infected bone defects through macrophage-mediated immunomodulation”}, volume = {12}, year = {2025}, }
• (2025). Correction to “[Aloe emodin alleviates radiation-induced heart disease via blocking P4HB lactylation and mitigating kynurenine metabolic disruption]”. ADVS, 12(12), 2501837. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202501837}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2501837}, shortjournal = {Adv. Sci.}, title = {Correction to “[Aloe emodin alleviates radiation-induced heart disease via blocking P4HB lactylation and mitigating kynurenine metabolic disruption]”}, volume = {12}, year = {2025}, }
• (2025). Corrigendum to “Nanomodified switch induced precise and moderate activation of CAR-T cells for solid tumors”. ADVS, 12(12), 2501355. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202501355}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2501355}, shortjournal = {Adv. Sci.}, title = {Corrigendum to “Nanomodified switch induced precise and moderate activation of CAR-T cells for solid tumors”}, volume = {12}, year = {2025}, }
• (2025). Highly efficient and durable ammonia electrolysis cell using zirfon separator. ADVS, 12(12), 2500579. (www)

  @article{ , abstract = {Most studies on ammonia electrolysis have focused on anion exchange membranes (AEMs), which face limitations in operating conditions, such as pH and ammonia concentration. This study introduces a novel concept of an ammonia electrolysis cell (AEC) utilizing a Zirfon separator capable of operating under high pH and ammonia concentrations. The Zirfon-based AECs achieve a peak current density of 915 mA cm −2 , representing the highest reported value in AEC literature. Additionally, the Zirfon separator exhibits less conductivity degradation than AEMs during cycling tests (Zirfon 14.1%, AEMs 30.2%), demonstrating superior durability of the Zirfon-based AEC.}, archive = {J_ADVS}, author = {Haeyong Shin and Sang-Mun Jung and Young Jin Lim and O-Jung Yim and Byung-Jo Lee and Kyu-Su Kim and In-Ho Baek and Jinwoo Baek and Jinhyeon Lee and Yong-Tae Kim}, doi = {10.1002/advs.202500579}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2500579}, shortjournal = {Adv. Sci.}, title = {Highly efficient and durable ammonia electrolysis cell using zirfon separator}, volume = {12}, year = {2025}, }
• (2025). Layered anion-mixed oxycompounds: Synthesis, properties, and applications. ADVS, 12(12), 2500477. (www)

  @article{ , abstract = {Layered anion-mixed oxycompounds have emerged as pivotal materials across diverse technological domains encompassing electronics, optics, sensing, catalysis, and energy applications. Capitalizing on the unique properties imparted by the additional anion, these compounds exhibit exceptional characteristics including ultra-large charge carrier mobility, giant second-harmonic generation, visible-light-driven photocatalysis, and outstanding thermoelectricity. This article aims to provide a comprehensive summary of layered anion-mixed oxychalcogenides, oxyhalides, oxynitrides, and oxypnictides. Organized by chemical composition and crystal structures, the classification of these oxycompounds precedes an in-depth exploration of various synthesis methodologies. Subsequently, their properties are elucidated in electronics, optics, magnetics, and ferroelectrics, contextualizing their utility in electronic, optical, and catalytic applications. The review culminates in a critical assessment of extant challenges and opportunities within this realm. Furthermore, insights are proffered into the future trajectory of research, underpinning the significance of advancing novel 2D multi-anion oxygenated compounds and their attendant applications.}, archive = {J_ADVS}, author = {Yange Luan and Yumin Li and Zhong Li and Bao Yue Zhang and Jian Zhen Ou}, doi = {10.1002/advs.202500477}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2500477}, shortjournal = {Adv. Sci.}, title = {Layered anion-mixed oxycompounds: Synthesis, properties, and applications}, volume = {12}, year = {2025}, }
• (2025). Spider silk-inspired conductive hydrogels for enhanced toughness and environmental resilience via dense hierarchical structuring. ADVS, 12(12), 2500397. (www)

  @article{ , abstract = {Conductive hydrogels, known for their biocompatibility and responsiveness to external stimuli, hold promise for biomedical applications like wearable sensors, soft robotics, and implantable electronics. However, their broader use is often constrained by limited toughness and environmental resilience, particularly under mechanical stress or extreme conditions. Inspired by the hierarchical structures of natural materials like spider silk, a strategy is developed to enhance both toughness and environmental tolerance in conductive hydrogels. By leveraging multiscale dynamics including pores, crystallization, and intermolecular interactions, a dense hierarchical structure is created that significantly improves toughness, reaching ≈90 MJ m⁻ 3 . This hydrogel withstands temperatures from −150 to 70 °C, pressure of 12 psi, and one-month storage under ambient conditions, while maintaining a lightweight profile of 0.25 g cm⁻ 3 . Additionally, its tunable rheological properties allow for high-resolution printing of desired shapes down to 220 µm, capable of supporting loads exceeding 164 kg m⁻ 2 . This study offers a versatile framework for designing durable materials for various applications.}, archive = {J_ADVS}, author = {Seokkyoon Hong and Jiwon Lee and Taewoong Park and Jinheon Jeong and Junsang Lee and Hyeonseo Joo and Juan C. Mesa and Claudia Benito Alston and Yuhyun Ji and Sergio Ruiz Vega and Cristian Barinaga and Jonghun Yi and Youngjun Lee and Jun Kim and Kate J. Won and Luis Solorio and Young L. Kim and Hyowon Lee and Dong Rip Kim and Chi Hwan Lee}, doi = {10.1002/advs.202500397}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2500397}, shortjournal = {Adv. Sci.}, title = {Spider silk-inspired conductive hydrogels for enhanced toughness and environmental resilience via dense hierarchical structuring}, volume = {12}, year = {2025}, }
• (2025). Daytime radiative cooling sheet functionalized by Al2O3-assisted organic composite. ADVS, 12(12), 2417584. (www)

  @article{ , abstract = {Daytime radiative cooling presents a compelling technology, noted for its efficiency and environmental friendliness. Recent studies have focused on not only the cooling capacity but also the applicability and versatility of this technology. This study introduces a daytime radiative cooler as a sheet with exceptional cooling performance. Its matrix is composed of polymethylmethacrylate (PMMA) and thermoplastic polyurethane (TPU), which are emerging organic materials suitable for radiative cooling. Furthermore, aluminum oxide (Al 2 O 3 ) is employed as a supporting dielectric particle to enhance cooling performance. An Al 2 O 3 -assisted organic composite (AOC) is created through electrospinning and hot-pressing, resulting in a bendable sheet form. The AOC sheet demonstrates a light reflectance of 97.9% across the solar spectral region (0.3–2.5 µm) and an emissivity of 95.2% within the atmospheric transparency window (ATW) of 8–13 µm. The cooling power, derived from optical properties, is calculated to be 120.1 Wm −2 . Experimental findings confirm the AOC sheet's capability to achieve 4.9 °C below ambient temperature and, when applied to a car model, to reduce the interior temperature by 12.7 °C.}, archive = {J_ADVS}, author = {Jaein Park and Dongwoo Chae and Hangyu Lim and Jisung Ha and Seongwoo Park and Hansang Sung and Chanwoong Park and Heon Lee}, doi = {10.1002/advs.202417584}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2417584}, shortjournal = {Adv. Sci.}, title = {Daytime radiative cooling sheet functionalized by Al2O3-assisted organic composite}, volume = {12}, year = {2025}, }
• (2025). Sono-piezo dynamic therapy: Utilizing piezoelectric materials as sonosensitizer for sonodynamic therapy. ADVS, 12(12), 2417439. (www)

  @article{ , abstract = {Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of SDT is constrained by the low water solubility, poor tumor specificity, and metabolic susceptibility of most sonosensitizers. Recent research has explored the use of piezoelectric materials as sonosensitizers in cancer treatment and inhibition of bacterial growth. Upon ultrasound excitation, the separation of electron–hole (e − –h + ) pairs occurs within the piezoelectric material. By improving the crystal structure of the material or incorporating other nanoparticles to prevent rapid recombination of e − –h + pairs, the piezoelectric material accumulates charges in the conduction band and valence band, achieving the redox potential of O 2 /·O 2 − . This enables the piezoelectric material to serve as a sonosensitizer, leading to the concept termed Sono-Piezo Dynamic Therapy (SPDT). This review aims to define the concept of SPDT, provide a systematic overview of the historical development of piezoelectric materials in the application of SDT, and elucidate the potential mechanisms by which piezoelectric materials act as sonosensitizers. Importantly, various piezoelectric materials will be discussed in terms of their feasibility, advantages, and disadvantages as sonosensitizers, offering new perspectives for identifying potential sonosensitizers.}, archive = {J_ADVS}, author = {Zhiguang Chen and Liang Sang and Yanjun Liu and ZhiQun Bai}, doi = {10.1002/advs.202417439}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2417439}, shortjournal = {Adv. Sci.}, title = {Sono-piezo dynamic therapy: Utilizing piezoelectric materials as sonosensitizer for sonodynamic therapy}, volume = {12}, year = {2025}, }
• (2025). Effect of extracellular vesicles derived from tumor cells on immune evasion. ADVS, 12(12), 2417357. (www)

  @article{ , abstract = {The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark of cancer. Antitumor immunity refers to the innate and adaptive immune responses that regulate cancer development and proliferation. Tumor immune evasion represents a major hindrance to effective anticancer treatment. Extracellular vesicles (EVs) are nano-sized and lipid-bilayer-enclosed particles that are secreted to the extracellular space by all cell types. They are critically involved in numerous biological functions including intercellular communication. Tumor-derived extracellular vesicles (TEVs) can transport a variety of cargo to modulate immune cells in the tumor microenvironment (TME). This review provides the latest update about how tumor cells evade immune surveillance by exploiting TEVs. First, the biogenesis of EVs and the cargo-sorting machinery are discussed. Second, how tumor cells modulate immune cell differentiation, activation, and function via TEVs to evade immune surveillance is illustrated. Last but not least, the novel antitumor strategies that can reverse immune escape are summarized.}, archive = {J_ADVS}, author = {Xuanfan Liu and Kenneth K.W. To and Qinsong Zeng and Liwu Fu}, doi = {10.1002/advs.202417357}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2417357}, shortjournal = {Adv. Sci.}, title = {Effect of extracellular vesicles derived from tumor cells on immune evasion}, volume = {12}, year = {2025}, }
• (2025). Activation of nuclear receptor CAR: A pathway to delay aging through enhanced capacity for xenobiotic resistance. ADVS, 12(12), 2416823. (www)

  @article{ , abstract = {Environmental factors are linked to aging and age-related diseases. Emerging evidence suggests that enhancing body's resistance to xenobiotics might be an anti-aging strategy. The constitutive androstane receptor (CAR) regulates drug-metabolizing enzymes and transporters, coordinating metabolism and immune responses to adapt to stress triggered by exogenous exposure. However, the impact of activating CAR on aging remains unknown. In this study, Caenorhabditis elegans ( C. elegans ), drug-induced premature aging mice, and senescence accelerated P8 (SAMP8) mice are used as models to explore the effects of CAR activation on lifespan and healthspan, along with the underlying mechanisms. The results showed that hCAR agonist CITCO and mCAR agonist TCPOBOP prolonged the lifespan and healthspan in model organism. The longevity effects of CITCO and TCPOBOP were attenuated in CAR homozygous nhr-8/daf-12 mutant C. elegans as well as CAR −/− mice. In C. elegans , CITCO activated both anti-stress and detoxification genes, and increased the resistance to environmental adversities. Additionally, the lifespan-extending and xenobiotic resistant effects of CITCO might be related to the regulation of age-related pathways. Furthermore, CITCO improved age-related neurodegeneration in C. elegans models. Taken together, the results suggest that the longevity effects of CAR agonists may be related to the enhancement of xenobiotic resistance of animals.}, archive = {J_ADVS}, author = {Jing Yu and Xiaoyan Gao and Hang Shi and Lijun Zhang and Wenlong Nie and Ruochen Zhang and Minglv Fang and Ying Liu and Yingxuan Yan and Bingbing Fan and Chengyuan Wu and Cheng Huang and Shengjie Fan}, doi = {10.1002/advs.202416823}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2416823}, shortjournal = {Adv. Sci.}, title = {Activation of nuclear receptor CAR: A pathway to delay aging through enhanced capacity for xenobiotic resistance}, volume = {12}, year = {2025}, }
• (2025). FRET-based sensor zebrafish reveal muscle cells do not undergo apoptosis in starvation or natural aging-induced muscle atrophy. ADVS, 12(12), 2416811. (www)

  @article{ , abstract = {Muscle atrophy occurs during natural aging and under disease conditions. Muscle cell apoptosis is considered one of the main causes of muscle atrophy, while several recent studies argued that muscle cells do not die during muscle atrophy. Here, sensor zebrafish are generated to visualize muscle cell apoptosis and the engulfment of dead muscle cells by macrophages. Using these sensor zebrafish, starvation, and natural aging-induced muscle atrophy models are established. The data showed that the diameters of muscle cells decreased in both models; however, muscle cell apoptosis is not found in the process of muscle atrophy. In starvation-induced muscle atrophy, it also showed that the number of nuclei in muscle cells remained constant, and there is no increase in the number of macrophages in muscle tissues, both of which further confirmed that muscle cells do not die. In both models, transcriptional analysis showed that the apoptosis pathway is down-regulated, and autophagy and protein degradation pathways are up-regulated. All these data indicated that although there is a great reduction of muscle mass during starvation or aging-induced muscle atrophy, muscle cells do not die by apoptosis. These findings provide new insights into muscle atrophy and can benefit the treatments for muscle atrophy-related diseases.}, archive = {J_ADVS}, author = {Hao Jia and Renfei Wu and Hongmei Yang and Kathy Qian Luo}, doi = {10.1002/advs.202416811}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2416811}, shortjournal = {Adv. Sci.}, title = {FRET-based sensor zebrafish reveal muscle cells do not undergo apoptosis in starvation or natural aging-induced muscle atrophy}, volume = {12}, year = {2025}, }
• (2025). Structure and wiring optimized TT/MT double-helical fiber sensors: Fabrication and applications in human motion monitoring and gesture recognition. ADVS, 12(12), 2416564. (www)

  @article{ , abstract = {A fibrous flexible sensor, with its small size, minimally burdens the human body, ranking among the most user-friendly flexible sensors. However, its application is often limited by damage caused by electrode movement, as flexible sensors are typically attached to joints, which can be greatly alleviated by placing the two electrodes on the same side. Inspired by the hydrogen bonds in the double-helical structure of DNA, the double-helical electrode design is commonly found and applied in fiber-based batteries and supercapacitors into fibrous flexible sensors through coaxial wet-spinning and further treatment. The double helical sensor exhibits high strength and maintains stable operation and is prepared under over 300% strain with gauge factors (GF) of 0.9, 39.5, and 349, respectively, in its working ranges. This unique single-sided electrode structure also enabled applications such as water flow sensing. The sensor into a smart glove capable of real-time is further integrated, five-channel finger motion detection, and used a convolutional neural network (CNN)-based machine learning algorithm to achieve 98.8% accuracy in recognizing six common gestures. This study provides a novel approach to optimize the electrode distribution in fiber-based flexible sensors through an internally encapsulated double-helical structure, making a significant contribution to the field of flexible sensing.}, archive = {J_ADVS}, author = {Ziwei Chen and Daoxiong Qian and Dandan Xie and Chunxia Gao and Jian Shi and Hideaki Morikawa and Chunhong Zhu}, doi = {10.1002/advs.202416564}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2416564}, shortjournal = {Adv. Sci.}, title = {Structure and wiring optimized TT/MT double-helical fiber sensors: Fabrication and applications in human motion monitoring and gesture recognition}, volume = {12}, year = {2025}, }
• (2025). PRDX6 prevents NNMT ubiquitination and degradation as a nonenzymatic mechanism to promote ovarian cancer progression. ADVS, 12(12), 2416484. (www)

  @article{ , abstract = {Cancer cells cope with oxidative stress for their proliferation and metastasis by equipping antioxidant systems, among which the antioxidant enzymes peroxiredoxins (PRDXs) play crucial roles. However, whether PRDXs exhibit nonenzymatic functions remains unclear. Here, it is shown that the 1-cysteine PRDX (PRDX6) upregulates nicotinamide N -methyltransferase (NNMT) to promote the growth and metastasis of ovarian cancer cells, independently of PRDX6's enzymatic activities. Mechanistically, PRDX6 interacts with NNMT to prevent its binding to the E3 ubiquitin ligase tripartite-motif protein 56 (TRIM56), leading to the inhibition of NNMT ubiquitination at lysine 23 and 210 and suppression of subsequent proteasomal degradation. In addition, PRDX6-mediated NNMT upregulation activates mitogen-activated protein kinase (MAPK) signaling, thereby promoting the growth and metastasis of ovarian cancer cells. Notably, PRDX6 overexpression is associated with higher NNMT protein levels in human ovarian cancer tissues and is predictive of poor prognosis of ovarian cancer patients. Overall, the findings illustrate a critical oncogenic mechanism of the antioxidant enzyme PRDX6 in promoting ovarian cancer progression beyond its enzymatic mechanisms.}, archive = {J_ADVS}, author = {Xingyun Wu and Li Luo and Mao Wang and Lixia Dong and Jiawu Fan and Yan Zeng and Sijia Li and Kui Wang}, doi = {10.1002/advs.202416484}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2416484}, shortjournal = {Adv. Sci.}, title = {PRDX6 prevents NNMT ubiquitination and degradation as a nonenzymatic mechanism to promote ovarian cancer progression}, volume = {12}, year = {2025}, }
• (2025). Designing Crystalline/Amorphous NVNPF/NCK cathode toward high-performance fully-printed flexible aqueous rechargeable sodium-ion batteries (ARSIBs). ADVS, 12(12), 2416120. (www)

  @article{ , abstract = {The flexible ARSIBs have great potential in portable and wearable electronics due to their high cost-effectiveness, safety, and amazing flexibility. Nevertheless, achieving both outstanding flexibility and high energy density remains a challenge. Herein, a battery-supercapacitor composite material Na 3 V 1.95 Ni 0.05 (PO 4 ) 2 F 3 /10%NC-KOH (NVNPF/NCK) with coexistence of crystalline and amorphous phases is fabricated by loading nitrogenous carbon (NC) onto Na 3 V 1.95 Ni 0.05 (PO 4 ) 2 F 3 (NVNPF) and etching with KOH. It demonstrates high specific capacity (187.26 mAh g −1 ), ultrahigh energy density (262.16 Wh kg −1 ), and excellent cycle performance (the capacity retention is 81% at 1 C after 500 cycles). The high performance is achieved by doping Ni 2 ⁺ loading NC and etching with KOH, which generates vacancy defects, enhances structural stability, and accelerates ion-diffusion kinetics. Furthermore, the fully-printed ARSIBs (F-NTP//NVNPF/NCK) with high specific capacity (60.37 mAh g −1 ), amazing energy density (72.44 Wh kg −1 ), and excellent cycle performance, are fabricated using screen-printing technique based on the NVNPF/NCK cathode and NaTi 1.7 Fe 0.3 (PO 4 ) 3 (F-NTP) anode. To the best of the authors' knowledge, F-NTP//NVNPF/NCK is the highest-performing fully-printed flexible ARSIB to date. In particular, these batteries can achieve tunability in shape and size, integration, and high-throughput manufacturing. Thus, this work can offer greater possibilities for the development of high-performance flexible ARSIBs.}, archive = {J_ADVS}, author = {Hehe Ren and Jing Liang and Qun Liu and Yuanjie Wei and Wei Wu}, doi = {10.1002/advs.202416120}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2416120}, shortjournal = {Adv. Sci.}, title = {Designing Crystalline/Amorphous NVNPF/NCK cathode toward high-performance fully-printed flexible aqueous rechargeable sodium-ion batteries (ARSIBs)}, volume = {12}, year = {2025}, }
• (2025). Evolutionary pro-to-thr mutation in the intrinsically disordered domain of ANP32 family members modulates their target binding modes. ADVS, 12(12), 2415566. (www)

  @article{ , abstract = {Gene duplication has allowed protein evolution toward novel functions and mechanisms. The differences between paralogous genes frequently rely on the sequence of disordered regions. For instance, in mammals, the chaperones ANP32A and ANP32B share a common evolutionary line and have some exchangeable functions based on their similar N-terminal domains. Nevertheless, their C-terminal low-complexity-acidic-regions (LCARs) display substantial sequence differences, unveiling some degree of variability between them, in agreement with their different tissue-specific expression patterns. These structural and computational results indicate that a substitution in the vicinity of the nuclear localization signal (NLS), of Pro in ANP32A for Thr in ANP32B, determines the overall compactness of the C-terminal LCAR. The different structural properties of the disordered region affect the binding mode of ANP32 members to their targets. This type of divergent binding mode is exemplified with the extra-mitochondrial cytochrome c (C c ), a well-known ANP32B partner and which now determine also binds to ANP32A; and with the RNA binding protein HuR, whose export to the cytoplasm is mediated by ANP32 proteins under stress. Therefore, differential expression patterns of ANP32A or ANP32B may affect the regulation of C c and HuR and can help to explain the distinct roles of these proteins in diseases.}, archive = {J_ADVS}, author = {Blanca Baños-Jaime and Ana B. Uceda-Mayo and Francisco Rivero-Rodríguez and Miguel Á. Casado-Combreras and Alejandro Velázquez-Cruz and Adrián Velázquez-Campoy and Laura Corrales-Guerrero and Miguel A. De la Rosa and Irene Díaz-Moreno}, doi = {10.1002/advs.202415566}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2415566}, shortjournal = {Adv. Sci.}, title = {Evolutionary pro-to-thr mutation in the intrinsically disordered domain of ANP32 family members modulates their target binding modes}, volume = {12}, year = {2025}, }
• (2025). PRMT5 maintains homeostasis of the intestinal epithelium by modulating cell proliferation and survival. ADVS, 12(12), 2415559. (www)

  @article{ , abstract = {Intestinal homeostasis is sustained by self-renewal of intestinal stem cells, which continuously divide and produce proliferative transit-amplifying (TA) and progenitor cells. Protein arginine methyltransferases 5 (PRMT5) plays a crucial role in regulating homeostasis of various mammalian tissues. However, its function in intestinal homeostasis remains elusive. In this study, conditional knockout of Prmt5 in the mouse intestinal epithelium leads to a reduction in stem cell population, suppression of cell proliferation, and increased cell apoptosis within the intestinal crypts, accompanied with shortened gut length, decreased mouse body weight, and eventual animal mortality. Additionally, Prmt5 deletion or its enzymatic inhibition in intestinal organoids in vitro also shows resembling cellular phenotypes. Methylome profiling identifies 90 potential Prmt5 substrates, which are involved in RNA-related biological processes and cell division. Consistently, Prmt5 depletion in intestinal organoids leads to aberrant alternative splicing in a subset of genes related to the mitotic cell cycle. Furthermore, Prmt5 loss triggers p53-mediated apoptosis in the intestinal epithelium. Collectively, the findings uncover an indispensable role of PRMT5 in promoting cell proliferation and survival, as well as maintaining stem cells in the gut epithelium.}, archive = {J_ADVS}, author = {Leilei Li and Zhe Zhang and Xu Wang and Haiyong Zhao and Liansheng Liu and Yanhui Xiao and Shan Hua and Ye-Guang Chen}, doi = {10.1002/advs.202415559}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2415559}, shortjournal = {Adv. Sci.}, title = {PRMT5 maintains homeostasis of the intestinal epithelium by modulating cell proliferation and survival}, volume = {12}, year = {2025}, }
• (2025). On-demand sintering of gold nanoparticles via controlled removal of o-nitrobenzyl thiol ligands under record-low power for conductive patterns. ADVS, 12(12), 2415496. (www)

  @article{ , abstract = {Metal nanoparticles-based nanoinks have shown potential for fabricating metallic components essential to the realization of innovative 3D-printed electronic devices. However, fabricating metallic patterns on flexible, heat-sensitive substrates remains challenging due to high temperature and high energy sources, such as intense pulsed light (IPL), involved in the sintering process. Here an efficient sintering method is presented using ultralow power UV by leveraging the photocleavable ligand, o -nitrobenzyl thiol (NT), – functionalized gold nanoparticles (AuNPs). The controlled removal of NT ligands upon UV irradiation enhances light absorption by reducing the filling factor of voids in the printed layer, increasing the layer temperature, and facilitating further ligand desorption. This positive feedback mechanism accelerates nanoparticle sintering at several orders of magnitude lower energy than IPL, achieving an electrical conductivity of 7.0 × 10 6 S m −1 . This nanoink promises the parallel printing of multimaterial components through ultralow power photonic sintering for fabricating multifunctional 3D-printed electronic devices.}, archive = {J_ADVS}, author = {Jisun Im and Charles Heaton and Nur R. E. Putri and Changxu Liu and Junichi Usuba and Kevin Butler and Michael Fay and Grace G. D. Han and Helia Hooshmand and Adam Thompson and Ricky Wildman and Richard Hague and Lyudmila Turyanska and Christopher Tuck}, doi = {10.1002/advs.202415496}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2415496}, shortjournal = {Adv. Sci.}, title = {On-demand sintering of gold nanoparticles via controlled removal of o-nitrobenzyl thiol ligands under record-low power for conductive patterns}, volume = {12}, year = {2025}, }
• (2025). Near infrared-mediated intracellular NADH delivery strengthens mitochondrial function and stability in muscle dysfunction model. ADVS, 12(12), 2415303. (www)

  @article{ , abstract = {Mitochondrial transfer emerges as a promising therapy for the restoration of mitochondrial function in damaged cells, mainly due to its limited immunogenicity. However, isolated mitochondria rapidly lose function because they produce little energy outside cells. Therefore, this study investigates whether near infrared (NIR)-mediated nicotinamide adenine dinucleotide (NADH) pre-treatment enhances mitochondrial function and stability in mitochondria-donor cells prior to transplantation. Clinical applications of NADH, an essential electron donor in the oxidative phosphorylation process, are restricted due to the limited cellular uptake of NADH. To address this, a photo-mediated method optimizes direct NADH delivery into cells and increases NADH absorption. L6 cells treated with NADH and irradiated with NIR enhanced NADH uptake, significantly improving mitochondrial energy production and function. Importantly, the improved functional characteristics of the mitochondria are maintained even after isolation from cells. Primed mitochondria, i.e., those enhanced by NIR-mediated NADH uptake (P-MT), are encapsulated in fusogenic liposomes and delivered into muscle cells with mitochondrial dysfunction. Compared to conventional mitochondria, P-MT mitochondria promote greater mitochondrial recovery and muscle regeneration. These findings suggest that NIR-mediated NADH delivery is an effective strategy for improving mitochondrial function, and has the potential to lead to novel treatments for mitochondrial disorders and muscle degeneration.}, archive = {J_ADVS}, author = {Hui Bang Cho and Hye-Ryoung Kim and Sujeong Lee and Chae Won Cho and Ji-In Park and Seulki Youn and Gyuwon So and Sumin Kang and Hye Jin Kim and Keun-Hong Park}, doi = {10.1002/advs.202415303}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2415303}, shortjournal = {Adv. Sci.}, title = {Near infrared-mediated intracellular NADH delivery strengthens mitochondrial function and stability in muscle dysfunction model}, volume = {12}, year = {2025}, }
• (2025). Inversion of circularly polarized luminescence in the left-handed chitosan-templated co-assemblies. ADVS, 12(12), 2415260. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL) materials are attractive due to their unique applications in fields such as 3D displays, information encryption, and chiroptical switches. Natural biomolecules-based CPL materials are gaining plenty of attention due to their chiral diversity and sustainability. However, it is still challenging to construct CPL materials with opposite CPL signs from a single natural biomolecule due to its inherent chirality. Here, chiral assemblies with opposite CPL signs using chitosan oligosaccharide (COS) and achiral luminescent dyes are successfully prepared. It is found that COS can serve as a chiral template to induce the ordered assembly of the dyes along the polymer chain through electrostatic attraction interaction. It is demonstrated experimentally that the structural planarity of the dye molecules is crucial for the formation of chiral co-assemblies. Interestingly, the left-handed COS-templated co-assemblies can emit CPL with opposite handedness, which is controlled by the helicity degree of the co-assemblies. This study not only deepens the understanding of the complex assembly of natural biomacromolecules but also provides new insights into the design and construction of CPL materials.}, archive = {J_ADVS}, author = {Yu An and Zhaocun Shen and Fang Zhang and Qiuya Yang and Zihan Han and Mingjie Wang and Hongze Ma and Linjie Yu and Wei Yuan and Kunyan Sui}, doi = {10.1002/advs.202415260}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2415260}, shortjournal = {Adv. Sci.}, title = {Inversion of circularly polarized luminescence in the left-handed chitosan-templated co-assemblies}, volume = {12}, year = {2025}, }
• (2025). Ultrasound super-resolution imaging of neonatal cerebral vascular reorganization. ADVS, 12(12), 2415235. (www)

  @article{ , abstract = {During the first days of neonatal growth, the central nervous system (CNS) develops self-regulatory mechanisms to ensure constant cerebral perfusion. However, this vascular neogenesis takes place at a microscopic scale that cannot be observed with current clinical imaging techniques. Ultrasound localization microscopy (ULM) allows us to observe micro-vessels of the order of a few microns at depths of several centimeters. This can be done using conventional clinical ultrasound scanners and contrast sequences (CEUS). In this study, ULM is used to observe the human microvasculature in neonatal patients undergoing treatment for life-threatening malformations forming direct connections between the cerebral arterial and venous systems. It is observed that neuroendovascular treatment of neonatal arteriovenous malformations causes remodeling and reorganization of the cerebral vasculature by also activating corticomedullary vascular connections. ULM enables us to follow microvascular changes in human neonates with high spatio-temporal resolution. ULM may provide a novel clinical translatable tool, particularly including cerebral imaging in very young patients.}, archive = {J_ADVS}, author = {Simone Schwarz and Louise Denis and Emmanuel Nedoschill and Adrian Buehler and Vera Danko and Alina C. Hilger and Francisco Brevis Nuñez and Nikola R. Dürr and Martin Schlunz-Hendann and Friedhelm Brassel and Ursula Felderhoff-Müser and Heiko Reutter and Joachim Woelfle and Jörg Jüngert and Christian Dohna-Schwake and Nora Bruns and Adrian P. Regensburger and Olivier Couture and Henriette Mandelbaum and Ferdinand Knieling}, doi = {10.1002/advs.202415235}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2415235}, shortjournal = {Adv. Sci.}, title = {Ultrasound super-resolution imaging of neonatal cerebral vascular reorganization}, volume = {12}, year = {2025}, }
• (2025). Tailoring tumor cell golgi apparatus-targeting self-assembled peptide for effective immunotherapy via reshaping MIF-mediated immunosuppressive network. ADVS, 12(12), 2415133. (www)

  @article{ , abstract = {The immunosuppressive network formed by the enhanced crosstalk between tumor cells and various types of immune cells may ultimately lead to the formation of tumor immunosuppressive microenvironment (TIME). The Golgi apparatus (GA) of tumor cells is a key organelle in the formation of a tumor immunosuppressive network. However, there are no studies to show whether interfering with the GA of tumor cells can reshape the immunosuppressive network to enhance the effectiveness of immunotherapy. Therefore, the tumor cell GA-targeting self-assembled peptide (NF-1) is tailored, and confirmed that NF-1 treatment can achieve an effective immunotherapy and found that tumor cell-derived GA-dependent migration inhibitory factor (MIF) mediates the formation of immunosuppressive network in breast cancer (BRCA) through multi-omics analysis, in vivo, and in vitro experiments. NF-1 treatment-induced MIF reduction can reshape the immunosuppressive network and convert a “cold” tumor into a “hot” tumor, thus enabling immunotherapy in BRCA and enhancing the ICB efficacy in colon adenocarcinoma (COAD). This study presents a general strategy for interfering with tumor GA for effective immunotherapy in BRCA, COAD, and other cancers characterized by a “cold” immune microenvironment.}, archive = {J_ADVS}, author = {Xiang Li and Chengxinqiao Wang and Junhan Liu and Guifang Deng and Yongqiang Deng and Fang Hu and Yupeng Wang and Dongfang Zhou}, doi = {10.1002/advs.202415133}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2415133}, shortjournal = {Adv. Sci.}, title = {Tailoring tumor cell golgi apparatus-targeting self-assembled peptide for effective immunotherapy via reshaping MIF-mediated immunosuppressive network}, volume = {12}, year = {2025}, }
• (2025). One-step centimeter-scale growth of sub-100-nm perovskite single-crystal arrays in ambient air for color painting. ADVS, 12(12), 2415105. (www)

  @article{ , abstract = {Halide perovskite single crystals have demonstrated enormous potential for next-generation integrated optoelectronic devices. However, there is a lack of a facile method to realize the controllable growth of large-scale, high-quality, and high-resolution perovskite single crystal arrays on diverse types of substrates, which hinders their application in practical scenarios. Here, a one-step wettability-guided blade coating approach is reported for the rapid in situ crystallization of large-scale, multicolor, and sub-100 nm perovskite single-crystal arrays in the ambient environment. By this strategy, the physical dimensions of perovskite single crystals can be precisely regulated from 90 to 260 nm, with a size variation coefficient < 10% and an area of over 900 mm 2 . All three typicalhalogen perovskites for multi-color luminescence, CsPbX 3 (X = Cl, Br, I) and their mixtures (Cl/Br or Br/I systems), are appliable to this fabrication process through the demonstration of complex RGB patterns with remarkable photoluminescence properties. Moreover, various rigid substrates such as silicon oxide (SiO 2 ), silicon (Si), and glass can also be used to construct the wettability-constrast templates where perovskite crystal nucleate and grow. After that, the perovskite single-crystal arrays or complex patterns can be transferred onto flexible substrates, for instance, COC. This method combines convenient solution processing with conventional photolithography to prepare the high-resolution, large-area, and superior-quality perovskite single crystal arrays in a high-throughput manner, showing great potential in the integration of perovskite nano-optoelectronic devices and chips.}, archive = {J_ADVS}, author = {Guannan Zhang and Zhao Sun and Zhuofei Gan and Chuwei Liang and Liyang Chen and Hongbo Mo and Yuanzhi Jiang and Mingjian Yuan and Aleksandra B. Djurišić and Ji Tae Kim and Wen-Di Li}, doi = {10.1002/advs.202415105}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2415105}, shortjournal = {Adv. Sci.}, title = {One-step centimeter-scale growth of sub-100-nm perovskite single-crystal arrays in ambient air for color painting}, volume = {12}, year = {2025}, }
• (2025). The negative role of proton insertion on the lifetime of vanadium-based aqueous zinc batteries. ADVS, 12(12), 2414762. (www)

  @article{ , abstract = {Vanadium oxides are attracted cathodes for aqueous zinc batteries owing to their high capacity. However, the limited cyclability of vanadium-based oxide cathodes, especially at low current densities, impedes their practical application. Here, it is revealed that proton insertion is responsible for the limited lifetime of vanadium oxides. Proton insertion promotes the dissolution of vanadium oxides, deteriorating electrochemical performance. Propylene carbonate (PC) is introduced into Zn(CF 3 SO 3 ) 2 electrolyte to regulate the coordination environment of water, forming PC-coordinated Zn 2+ solvation structure and [H 2 O-CF 3 SO 3 − -PC] complex. The optimized coordination environment of water weakens the adsorption energy between water molecules and vanadium oxides, inhibiting proton insertion. As a result, vanadium-based oxides cathode without proton insertion can maintain the stability of crystal structure and avoid the dissolution of V. Taking CaV 8 O 20 ·nH 2 O as cathode, Zn||CaV 8 O 20 ·nH 2 O battery without proton insertion performs enhanced cycling performance. This work not only reveals the negative effect of proton insertion on the lifetime of vanadium-based oxides cathode but also provides an effective strategy to modulate proton insertion.}, archive = {J_ADVS}, author = {Chaoqiong Zhu and Limin Zheng and Hao Ruan and Meng Xiao and Meng Ye and Ting Chen and Fang Wan and Xiaodong Guo}, doi = {10.1002/advs.202414762}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414762}, shortjournal = {Adv. Sci.}, title = {The negative role of proton insertion on the lifetime of vanadium-based aqueous zinc batteries}, volume = {12}, year = {2025}, }
• (2025). Toward a new understanding of graphene oxide photolysis: The role of photoreduction in degradation pathway. ADVS, 12(12), 2414716. (www)

  @article{ , abstract = {Graphene oxide (GO) is developed in various applications owing to its fascinating physicochemical properties. However, the weak photostability always leads to inevitable photolysis of GO during the use, storage, and application. Indirect photolysis has a significant impact on the structure of GO via causing fragmentation and degradation, while the pathway can be divided into two stages. In the early stage, photoreduction is the dominant reaction to generate porous reduction GO (PrGO). Then H 2 O 2 breaks PrGO into fragments, and eventually, the fragmented GO is converted into CO 2 by OH radicals. The generation of porous structures in early photoreduction is a crucial premise for the subsequent photodegradation, while GO flakes without porous structure cannot be broken by H 2 O 2 and OH. In this work, a deep insight into the indirect photolysis pathway and the committed step is provided, which may bring some advanced ideas for enhancing GO stability in practical application.}, archive = {J_ADVS}, author = {Yuchen Yang and Nanzhi Zheng and Chen Ma and Silong Chen and Wenhua Chen and Guohua Chen}, doi = {10.1002/advs.202414716}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414716}, shortjournal = {Adv. Sci.}, title = {Toward a new understanding of graphene oxide photolysis: The role of photoreduction in degradation pathway}, volume = {12}, year = {2025}, }
• (2025). Unveiling the Li/Electrolyte interface behavior for dendrite-free all-solid-state lithium metal batteries by operando nano-focus WAXS. ADVS, 12(12), 2414714. (www)

  @article{ , abstract = {Poly(ethylene oxide) (PEO)-based solid composite electrolytes suffer from poor conductivity and lithium dendrite growth, especially toward the metallic lithium metal anode. In this study, succinonitrile (SN) is incorporated into a PEO composite electrolyte to fabricate an electrode-compatible electrolyte with good electrochemical performance. The SN-doped electrolyte successfully inhibits the lithium dendrite growth and facilitates the SEI layer formation, as determined by the operando nanofocus wide-angle X-ray scattering (nWAXS), meanwhile, stably cycled over 500 h in Li/SN-PEO/Li cell. Apart from the observation of lithium dendrite, the robust SEI layer formation mechanism in the first cycle is investigated in the SN-enhanced composite electrolyte by nWAXS. The inorganic electrochemical reaction products, LiF and Li 3 N, are found to initially deposit on the electrolyte side, progressively extending toward the lithium metal anode. This growth process effectively protected the metallic lithium, inhibited electron transfer, and facilitated Li⁺ transport. The study not only demonstrates a high-performance interfacial-stable lithium metal battery with composite electrolyte but also introduces a novel strategy for real-time visualizing dendrite formation and SEI growth directing at the interface area of electrolyte and metallic lithium.}, archive = {J_ADVS}, author = {Yuxin Liang and Fabian A.C. Apfelbeck and Kun Sun and Yingying Yan and Lyuyang Cheng and Guangjiu Pan and Tianle Zheng and Yajun Cheng and Anton Davydok and Christina Krywka and Peter Müller-Buschbaum}, doi = {10.1002/advs.202414714}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414714}, shortjournal = {Adv. Sci.}, title = {Unveiling the Li/Electrolyte interface behavior for dendrite-free all-solid-state lithium metal batteries by operando nano-focus WAXS}, volume = {12}, year = {2025}, }
• (2025). A transformative wearable corneal microneedle patch for efficient therapy of ocular injury and infection. ADVS, 12(12), 2414548. (www)

  @article{ , abstract = {Ocular injury and infection are significant causes of vision impairment and blindness globally. Effective treatment is, however, challenging due to the physical barrier of the cornea, which restricts drug penetration in the eye, as well as the presence of eye injury that necessitates continuous delivery of growth factors on the ocular surface for cornea healing. Here, we introduce a transformative wearable corneal microneedle (MN) patch designed for efficient therapy of ocular injury and infection. The MN patch comprises water-soluble tips that encapsulate antibacterial nanoparticles (NPs), along with a transformative backing layer that contains epidermal growth factor (EGF). Upon insertion into the eye, the MN tips dissolve swiftly within the cornea stroma, resulting in the release of the antimicrobial NPs to efficiently eradicate bacteria. Meanwhile, the residual backing layer undergoes rapid in situ transformation upon contact with mildly acidic fluid from infected corneal edema, converting into a contact lens that conforms to the eye's surface, which facilitates sustained release of EGF on the ocular surface over 8 h to promote corneal healing. Benefiting from these features, the designed transformative corneal MN patch demonstrates superior efficacy in treating ocular injuries and infections in vivo, offering a promising therapeutic strategy to manage eye diseases.}, archive = {J_ADVS}, author = {Xue Jiang and Shuhua Liu and Jiayi Chen and Jiapeng Lei and Wenjing Meng and Xueyang Wang and Zhigang Chu and Wei Li}, doi = {10.1002/advs.202414548}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414548}, shortjournal = {Adv. Sci.}, title = {A transformative wearable corneal microneedle patch for efficient therapy of ocular injury and infection}, volume = {12}, year = {2025}, }
• (2025). Biomineralized nanocomposite-integrated microneedle patch for combined brachytherapy and photothermal therapy in postoperative melanoma recurrence and infectious wound healing. ADVS, 12(12), 2414468. (www)

  @article{ , abstract = {In the surgical management of malignant melanoma, incomplete tumor resection and large-area cutaneous defects are major contributors to high locoregional recurrence and uncontrolled wound infections, resulting in poor prognosis and prolonged recovery times for patients. Herein, a versatile nanocomposite microneedle patch (referred to as GM-Ag 2 S/Ca 32 P) is designed to simultaneously eliminate residual tumor post-surgery and promote the healing of infectious wounds. This microneedle patch effectively penetrates subcutaneous tissues, delivering therapeutic payloads to infiltrating tumor cells and bacteria. The Ag 2 S/Ca 32 P nanocomposites encapsulated within the microneedle patch decompose in the acidic microenvironment of tumors and bacterial biofilms, releasing radioactive 32 P and Ag 2 S nanodots, which enhance tumor eradication and bacteria killing through synergistic brachytherapy and photothermal therapy (PTT). Moreover, the nanocomposite microneedle patch promotes scar-free wound healing by reducing inflammation, and promoting granulation tissue formation, collagen deposition, and angiogenesis, thanks to localized hyperthermia, radiation, and the swelling and biodegradation of the microneedle matrices. This microneedle patch-based postoperative adjuvant therapy offers a comprehensive strategy for addressing melanoma recurrence and infectious wound healing, with promising potential for clinical application in postsurgical management.}, archive = {J_ADVS}, author = {Peng Liu and Lu Hao and Jessica C. Hsu and Ming Zhou and Zhisheng Luo and Ying Peng and Weibo Cai and Shuo Hu}, doi = {10.1002/advs.202414468}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414468}, shortjournal = {Adv. Sci.}, title = {Biomineralized nanocomposite-integrated microneedle patch for combined brachytherapy and photothermal therapy in postoperative melanoma recurrence and infectious wound healing}, volume = {12}, year = {2025}, }
• (2025). Thermoplastic elastomer-reinforced hydrogels with excellent mechanical properties, swelling resistance, and biocompatibility. ADVS, 12(12), 2414339. (www)

  @article{ , abstract = {Strong and tough hydrogels are promising candidates for artificial soft tissues, yet significant challenges remain in developing biocompatible, anti-swelling hydrogels that simultaneously exhibit high strength, fracture strain, toughness, and fatigue resistance. Herein, thermoplastic elastomer-reinforced polyvinyl alcohol (PVA) hydrogels are prepared through a synergistic combination of phase separation, wet-annealing, and quenching. This approach markedly enhances the crystallinity of the hydrogels and the interfacial interaction between PVA and thermoplastic polyurethane (TPU). This strategy results in the simultaneous improvement of the mechanical properties of the hydrogels, achieving a tensile strength of 11.19 ± 0.80 MPa, toughness of 62.67 ± 10.66 MJ m −3 , fracture strain of 1030 ± 106%, and fatigue threshold of 1377.83 ± 62.78 J m −2 . Furthermore, the composite hydrogels demonstrate excellent swelling resistance, biocompatibility, and cytocompatibility. This study presents a novel approach for fabricating strong, tough, stretchable, biocompatible, and fatigue- and swelling-resistant hydrogels with promising applications in soft tissues, flexible electronics, and load-bearing biomaterials.}, archive = {J_ADVS}, author = {Zhanqi Liu and Hechuan Zhang and Ruigang Zhou and Haiyang Gao and Yongchuan Wu and Yuqing Wang and Haidi Wu and Cheng Guan and Ling Wang and Longcheng Tang and Pingan Song and Huaiguo Xue and Jiefeng Gao}, doi = {10.1002/advs.202414339}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414339}, shortjournal = {Adv. Sci.}, title = {Thermoplastic elastomer-reinforced hydrogels with excellent mechanical properties, swelling resistance, and biocompatibility}, volume = {12}, year = {2025}, }
• (2025). Multi-step assembly of an RNA-liposome nanoparticle formulation revealed by real-time, single-particle quantitative imaging. ADVS, 12(12), 2414305. (www)

  @article{ , abstract = {Self-assembly plays a critical role in nanoparticle-based applications. However, it remains challenging to monitor the self-assembly of multi-component nanomaterials at a single-particle level, in real-time, with high throughput, and in a model-independent manner. Here, multi-color fluorescence microscopy is applied to track the assembly of both liposomes and mRNA simultaneously in clinical mRNA-based cancer immunotherapy. Imaging reveals that the assembly occurs in discrete steps: initially, RNA adsorbs onto the liposomes; then, the RNA-coated liposomes cluster into heterogeneous structures ranging from sub-micrometer to tens of micrometers. The clustering process is consistent with a Smoluchowski model with a Brownian diffusion kernel. The transition between the two steps of assembly is determined by the orientation of RNA-mediated interactions. Given the facile application of this approach and the ubiquity of the components studied, the imaging and analysis in this work are readily applied to monitor multi-component assembly of diverse nanomaterials.}, archive = {J_ADVS}, author = {Michael C. Chung and Hector R. Mendez-Gomez and Dhruvkumar Soni and Reagan McGinley and Alen Zacharia and Jewel Ashbrook and Brian Stover and Adam J. Grippin and Elias J. Sayour and Juan Guan}, doi = {10.1002/advs.202414305}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414305}, shortjournal = {Adv. Sci.}, title = {Multi-step assembly of an RNA-liposome nanoparticle formulation revealed by real-time, single-particle quantitative imaging}, volume = {12}, year = {2025}, }
• (2025). Temporal association cortex gates sound-evoked arousal from NREM sleep. ADVS, 12(12), 2414271. (www)

  @article{ , abstract = {Sound-evoked wakefulness from sleep is crucial in daily life, yet its neural mechanisms remain poorly understood. It is found that CaMKIIα+ neurons in the temporal association cortex (TeA) of mice are not essential for natural awakening from sleep. However, optogenetic activation of these neurons reliably induces wakefulness from non-rapid eye movement (NREM) sleep but not from rapid eye movement (REM) sleep. In vivo electrophysiological and calcium recordings further demonstrated that TeA neurons are monotonically tuned to sound intensity but not frequency. More importantly, it is found that the activity of CaMKIIα+ neurons in TeA can gate sound-evoked arousal from NREM sleep, which is further confirmed by optogenetic manipulations. Further investigation reveals that the baseline excitability of TeA CaMKIIα+ neurons and the delta oscillations in the electroencephalogram are particularly important in regulating the evoked activity of TeA neurons. Anatomical and functional screening of downstream targets of TeA reveals that excitatory projections from TeA glutamatergic neurons to glutamatergic neurons in the basolateral/lateral amygdala are critical for modulating sound-evoked arousal from NREM sleep. These findings uncover a top-down regulatory circuit that selectively governs sound-evoked arousal from NREM sleep, with the TeA functioning as a key connecting cortex to subcortical regions.}, archive = {J_ADVS}, author = {Haipeng Yu and Jincheng Wang and Ruiqi Pang and Penghui Chen and Tiantian Luo and Xuan Zhang and Yatao Liao and Chao Hu and Miaoqing Gu and Bingmin Luo and Zhiyue Shi and Mengyao Li and Yueting Zhang and Qiaoqian Wei and Wei Yuan and Hui Xie and Zhiyi Chen and Hongbang Liu and Shuancheng Ren and Xiaowei Chen and Yi Zhou}, doi = {10.1002/advs.202414271}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414271}, shortjournal = {Adv. Sci.}, title = {Temporal association cortex gates sound-evoked arousal from NREM sleep}, volume = {12}, year = {2025}, }
• (2025). A neural device inspired by neuronal oscillatory activity with intrinsic perception and decision-making. ADVS, 12(12), 2414173. (www)

  @article{ , abstract = {Bionic neural devices often feature complex structures with multiple interfaces, requiring extensive post-processing. In this paper, a neural device with intrinsic perception and decision-making (NDIPD), inspired by neuronal oscillatory activity is introduced. The device utilizes alternating signals generated by coupling the human body with the power-frequency electromagnetic field as both a signal source and energy source, mimicking neuronal oscillatory activity. The peaks and valleys of the alternating signal are differentially modulated to replicate the baseline shift process in neuronal oscillatory activity. By comparing the amplitude of the peaks and valleys in the NDIPD's electrical output signal, the device achieves intrinsic perception and decision-making regarding the location of mechanical stimulation. This is accomplished using a single interface, which reduces data transmission, simplifies functionality, and eliminates the need for an external power supply. The NDIPD demonstrates a low-pressure detection limit (<0.02 N), fast response time (<20 ms), and exceptional stability (>200 000 cycles). It shows great potential for applications such as game control, UAV navigation, and virtual vehicle driving. The innovative energy supply method and sensing mechanism are expected to open new avenues in the development of bionic neural devices.}, archive = {J_ADVS}, author = {Congtian Gu and Guoliang Ma and Mengze Zhang and Hu Shen and Liaoyuan Pu and Yanhe Song and Shilong Yan and Dakai Wang and Kaixian Ba and Bin Yu and Zhiwu Han and Luquan Ren}, doi = {10.1002/advs.202414173}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414173}, shortjournal = {Adv. Sci.}, title = {A neural device inspired by neuronal oscillatory activity with intrinsic perception and decision-making}, volume = {12}, year = {2025}, }
• (2025). Dominant role of coexisting ruthenium nanoclusters over single atoms to enhance alkaline hydrogen evolution reaction. ADVS, 12(12), 2414012. (www)

  @article{ , abstract = {Developing efficient and cost-effective electrocatalysts to replace expensive carbon-supported platinum nanoparticles for the alkaline hydrogen evolution reaction remains an important challenge. Recently, an innovative catalyst, composed of ruthenium single atoms (Ru 1 ) integrated with small Ru nanoclusters (Ru NC ), has attracted considerable attention from the scientific community. However, because of its complexity, this catalyst remains a topic of some debate. Here, a method is reported of precisely controlling the ratios of Ru 1 to Ru NC on a nitrogenated carbon (NC)-based porous organic framework to produce Ru/NC catalysts, by using different amounts (0, 5, 10 wt.%) of reducing agent. The Ru/NC–10 catalyst, formed with 10 wt.% reducing agent, delivered the best performance under alkaline conditions, indicating that Ru NC played a significant role in actual alkaline hydrogen evolution reaction (HER). An anion exchange membrane water electrolyzer (AEMWE) system using the Ru/NC–10 catalyst required a significantly lower operating voltage (1.72 V) than the commercial Pt/C catalyst (1.95 V) to achieve 500 mA cm −2 . Moreover, the system can be operated at 100 mA cm −2 without notable performance decay for over 180 h. Theoretical calculations supported these experimental findings that Ru 1 contributed to the water dissociation process, while Ru NC is more actively associated with the hydrogen recombination process.}, archive = {J_ADVS}, author = {Jae-Hoon Baek and Seong Hyeon Kweon and Hyuk-Jun Noh and Do Hyung Kweon and Jeong-Min Seo and Se Jung Lee and Sang Kyu Kwak and Jong-Beom Baek}, doi = {10.1002/advs.202414012}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2414012}, shortjournal = {Adv. Sci.}, title = {Dominant role of coexisting ruthenium nanoclusters over single atoms to enhance alkaline hydrogen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). Lgals3 promotes calcium oxalate crystal formation and kidney injury through histone lactylation-mediated FGFR4 activation. ADVS, 12(12), 2413937. (www)

  @article{ , abstract = {The incidence of kidney stones is increasing worldwide. However, the underlying mechanism of the process of kidney stone formation and the kidney damage caused are not well understood. Here, it is observed that Lgals3, a β-galactoside-binding protein, is significantly increased in tissues with calcium oxalate (CaOx) stones, and in both in vivo and in vitro models. Lgals3 expression is positively correlated with the deposition of CaOx crystals. Knockout of Lgals3 markedly reduces the deposition of CaOx crystal and renal fibrosis in vivo. Furthermore, Lgals3 deficiency decrease the glycolytic rate and lactate production during the process of CaOx deposition and inhibited histone lactylation of H3K18la. Mechanistic studies shows that Lgals3 directly interacted with the key glycolysis protein pyruvate kinase M2 (PKM2) and promoted its expression by modulating E3 ligase Trim21, preventing the ubiquitination of PKM2. Furthermore, H3K18 lactylation promoted CaOx crystal deposition and kidney injury in vivo and in vitro. Lgals3 deficiency inhibites the transcription, activation, and expression of FGFR4 through inhibition of H3K18la. These findings suggest that Lgals3 may play a key role in CaOx stone formation and kidney injury by interacting with PKM2 and promoting both H3K18la-mediated gene transcription and activation.}, archive = {J_ADVS}, author = {Zehua Ye and Yushi Sun and Songyuan Yang and Lei Li and Bojun Li and Yuqi Xia and Tianhui Yuan and Weimin Yu and Lijia Chen and Xiangjun Zhou and Fan Cheng}, doi = {10.1002/advs.202413937}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413937}, shortjournal = {Adv. Sci.}, title = {Lgals3 promotes calcium oxalate crystal formation and kidney injury through histone lactylation-mediated FGFR4 activation}, volume = {12}, year = {2025}, }
• (2025). Highly stable electronics based on β-Ga2O3 for advanced memory applications. ADVS, 12(12), 2413846. (www)

  @article{ , abstract = {Wide-bandgap (WBG) semiconductors are at the forefront of driving innovations in electronic technology, perpetuating Moore's Law and opening up new avenues for electronic devices. Although β -Ga 2 O 3 has attracted extensive research interest in advanced electronics, its high-temperature and high-speed volatile memory applications in harsh environment has been largely overlooked. Herein, a high-performance hexagonal boron nitride (h-BN)/ β -Ga 2 O 3 heterostructure junction field-effect transistor (HJFET) is fabricated, exhibiting an off-state current as low as ≈10 fA, a high on/off current ratio of ≈10 8 , a low contact resistance of 5.6 Ω·mm, and an impressive field-effect electron mobility of 156 cm 2 （Vs） −1 . Notably, the current h-BN/ β -Ga 2 O 3 HJFET exhibits outstanding thermal reliability in the ultra-wide temperature range from 223 to 573 K, as well as long-term environmental stability in air, which confirms its inherent capability of operation in harsh environments. Moreover, the h-BN/ β -Ga 2 O 3 HJFET demonstrates successful applications for accelerator-in-memory computing fields, including dynamic random-access memory structure and neural network computations. These superior characteristics position β -Ga₂O₃-based electronics as highly promising for applications in extreme environments, with particular relevance to the automotive, aerospace, and sensor sectors.}, archive = {J_ADVS}, author = {Xiaoxi Li and Yu-Chun Li and Yingguo Yang and Bitao Dong and Yuhang Liu and Lina Li and Linfeng Pan and Gengsheng Chen and Yue Hao and Genquan Han}, doi = {10.1002/advs.202413846}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413846}, shortjournal = {Adv. Sci.}, title = {Highly stable electronics based on β-Ga2O3 for advanced memory applications}, volume = {12}, year = {2025}, }
• (2025). Accurately models the relationship between physical response and structure using Kolmogorov–Arnold network. ADVS, 12(12), 2413805. (www)

  @article{ , abstract = {Artificial intelligence (AI) in science is a key area of modern research. However, many current machine learning methods lack interpretability, making it difficult to grasp the physical mechanisms behind various phenomena, which hampers progress in related fields. This study focuses on the Poisson's ratio of a hexagonal lattice elastic network as it varies with structural deformation. By employing the Kolmogorov–Arnold Network (KAN), the transition of the network's Poisson's ratio from positive to negative as the hexagonal structural element shifts from a convex polygon to a concave polygon was accurately predicted. The KAN provides a clear mathematical framework that describes this transition, revealing the connection between the Poisson's ratio and the geometric properties of the hexagonal element, and accurately identifying the geometric parameters at which the Poisson's ratio equals zero. This work demonstrates the significant potential of the KAN network to clarify the mathematical relationships that underpin physical responses and structural behaviors.}, archive = {J_ADVS}, author = {Yang Wang and Changliang Zhu and Shuzhe Zhang and Changsheng Xiang and Zhibin Gao and Guimei Zhu and Jun Sun and Xiangdong Ding and Baowen Li and Xiangying Shen}, doi = {10.1002/advs.202413805}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413805}, shortjournal = {Adv. Sci.}, title = {Accurately models the relationship between physical response and structure using Kolmogorov–Arnold network}, volume = {12}, year = {2025}, }
• (2025). Longitudinal MRI-driven multi-modality approach for predicting pathological complete response and b cell infiltration in breast cancer. ADVS, 12(12), 2413702. (www)

  @article{ , abstract = {Accurately predicting pathological complete response (pCR) to neoadjuvant treatment (NAT) in breast cancer remains challenging due to tumor heterogeneity. This study enrolled 2279 patients across 12 centers and develops a novel multi-modality model integrating longitudinal magnetic resonance imaging (MRI) spatial habitat radiomics, transcriptomics, and single-cell RNA sequencing for predicting pCR. By analyzing tumor subregions on multi-timepoint MRI, the model captures dynamic intra-tumoral heterogeneity during NAT. It shows superior performance over traditional radiomics, with areas under the curve of 0.863, 0.813, and 0.888 in the external validation, immunotherapy, and multi-omics cohorts, respectively. Subgroup analysis shows its robustness across varying molecular subtypes and clinical stages. Transcriptomic and single-cell RNA sequencing analysis reveals that high model scores correlate with increased immune activity, notably elevated B cell infiltration, indicating the biological basis of the imaging model. The integration of imaging and molecular data demonstrates promise in spatial habitat radiomics to monitor dynamic changes in tumor heterogeneity during NAT. In clinical practice, this study provides a noninvasive tool to accurately predict pCR, with the potential to guide treatment planning and improve breast-conserving surgery rates. Despite promising results, the model requires prospective validation to confirm its utility across diverse patient populations and clinical settings.}, archive = {J_ADVS}, author = {Yu-Hong Huang and Zhen-Yi Shi and Teng Zhu and Tian-Han Zhou and Yi Li and Wei Li and Han Qiu and Si-Qi Wang and Li-Fang He and Zhi-Yong Wu and Ying Lin and Qian Wang and Wen-Chao Gu and Chang-Cong Gu and Xin-Yang Song and Yang Zhou and Dao-Gang Guan and Kun Wang}, doi = {10.1002/advs.202413702}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413702}, shortjournal = {Adv. Sci.}, title = {Longitudinal MRI-driven multi-modality approach for predicting pathological complete response and b cell infiltration in breast cancer}, volume = {12}, year = {2025}, }
• (2025). Boosted CO2 photoreduction performance by CdSe nanoplatelets via se vacancy engineering. ADVS, 12(12), 2413684. (www)

  @article{ , abstract = {2D metal-chalcogenide nanoplatelets (NPLs) exhibit promising photocatalysis properties due to their ultrathin morphology, high surface-to-volume ratio, and enhanced in-plane electron transport mobility. However, NPLs, especially cadmium chalcogenides, encounter challenges in CO 2 photoreduction due to insufficient solar energy utilization and fast recombination of photogenerated charge carriers. Defect engineering offers a potential solution but often encounters difficulties maintaining structural integrity, mechanical stability, and electrical conductivity. Herein, by taking two monolayers (2ML) CdSe NPLs as a model system, selenium (Se) vacancies confined in atomic layers can enhance charge separation and conductivity. A straightforward approach to create Se vacancies in various monolayers CdSe NPLs (2, 4, and 5ML) has been developed, enabling efficient CO 2 photoreduction with a 4-fold increase in CO generation compared to their defect-free counterparts. Significantly, accounting for higher charge density and efficient carrier transport due to Se vacancies, defective 2ML CdSe NPLs (V Se -2ML CdSe) exhibit CO evolution performance up to 2557.5 µmol g − ¹ h − ¹ with no significant decay over 5 h, which is an order of magnitude higher than that of common semiconductor catalysts. This study establishes a practical way to design advanced 2D semiconductor photocatalysts to achieve efficient CO 2 photoreduction via defect engineering.}, archive = {J_ADVS}, author = {Huanhuan Luo and Xuanzhao Lu and Yue Cao and Zhaoyuan Lyu and Shichao Ding and Yuehe Lin and Yang Zhou and Wenlei Zhu and Yuanyuan Wang}, doi = {10.1002/advs.202413684}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413684}, shortjournal = {Adv. Sci.}, title = {Boosted CO2 photoreduction performance by CdSe nanoplatelets via se vacancy engineering}, volume = {12}, year = {2025}, }
• (2025). Superior high-rate ni-rich lithium batteries based on fast ion-desolvation and stable solid-electrolyte interphase. ADVS, 12(12), 2413419. (www)

  @article{ , abstract = {The fast charging-discharging performance of power batteries has very practical significance. In terms of electrochemistry, this requires fast and stable kinetics for electrochemical reaction processes. Despite the great complexity of kinetics, it is clear that lithium-ion desolvation and a subsequent step of crossing through cathode-electrolyte interphase (CEI) are crucial to high-rate performance, in which the two key steps depend heavily on the working electrolyte formula. In this work, a customized electrolyte is developed to coordinate ion desolvation and interphase formation by introducing vinylene carbonate (VC), triphenylboroxin (TPBX), and fluoroethylene carbonate (FEC) but excluding ethylene carbonate (EC). Serving Ni-rich cathodes, the customized electrolyte generates a double-layered CEI, LiF-dominated inorganics inner layer, and ROCOOLi-dominated organics outer layer, which is not only stable and very efficient for lithium ion transport. Meanwhile, a -dominated solvation structure is induced and effectively decreases the desolvation energy to 29.72 kJ mol −1 , supporting fast lithium ion transport in the cathode interfacial processes. Consequently, the Ni-rich lithium-ion battery achieves a stable long cycle at a superior high rate of 10 C.}, archive = {J_ADVS}, author = {Zhenxue Xiao and Siyuan Wu and Xiaozhe Ren and Minfei Fei and Shuai Hao and Xueping Gao and Guoran Li}, doi = {10.1002/advs.202413419}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413419}, shortjournal = {Adv. Sci.}, title = {Superior high-rate ni-rich lithium batteries based on fast ion-desolvation and stable solid-electrolyte interphase}, volume = {12}, year = {2025}, }
• (2025). LncRNA TUG1 repressed angiogenesis by promoting the ubiquitination of HuR and inhibiting its nuclear translocation in cerebral ischemic reperfusion injury. ADVS, 12(12), 2413333. (www)

  @article{ , abstract = {Although both Taurine Upregulated Gene 1(TUG1) and Human Antigen R (HuR) play significant regulatory roles in Cerebral Ischemic Reperfusion Injury (CIRI), their potential pro-angiogenesis mechanisms in CIRI remain unclear. Methods: Herein, the biological roles of TUG1 and HuR in angiogenesis are first confirmed. Following that, HuR-binding VEGFA mRNAs are identified via the Fluorescence In Situ Hybridization (FISH), RNA Immunoprecipitation (RIP), and Cross-Linking Immunoprecipitation (CLIP) assays. Actinomycin D and polysomal assays are also employed to confirm VEGFA mRNA stability. The co-localization of TUG1 with HuR is confirmed using FISH, while the RIP and RNA pull-down assays are employed to elucidate their interplay. The direct binding between TUG1 and HuR is confirmed through the CLIP assay. Co-Immunoprecipitation (Co-IP) and rescue experiments are performed to further elucidate TUG1-HuR interactions. Results: While TUG1 repressed angiogenesis and aggravated CIRI, HuR exerted contrary effects. Specifically, HuR bound directly to VEGFA mRNA, a phenomenon that enhanced VEGFA mRNA stability. Conversely, TUG1 binds to HuR directly, inhibiting its nuclear translocation and promoting its ubiquitination, ultimately reducing VEGFA mRNA stability. Conclusions: It is found that TUG1 can inhibit angiogenesis in CIRI through the HuR/VEGFA mRNA axis.}, archive = {J_ADVS}, author = {Hongxiang Jiang and Qiang Cai and Peidong He and Fei Li and Qianxue Chen}, doi = {10.1002/advs.202413333}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413333}, shortjournal = {Adv. Sci.}, title = {LncRNA TUG1 repressed angiogenesis by promoting the ubiquitination of HuR and inhibiting its nuclear translocation in cerebral ischemic reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Targeting the e prostanoid receptor EP4 mitigates cardiac fibrosis induced by β-adrenergic activation. ADVS, 12(12), 2413324. (www)

  @article{ , abstract = {Sustained β-adrenergic activation induces cardiac fibrosis characterized by excessive deposition of extracellular matrix (ECM). Prostaglandin E 2 (PGE 2 ) receptor EP4 is essential for cardiovascular homeostasis. This study aims to investigate the roles of cardiomyocyte (CM) and cardiac fibroblast (CF) EP4 in isoproterenol (ISO)-induced cardiac fibrosis. By crossing the EP4 f/f mice with α-MyHC-Cre or S100A4-Cre mice, this work obtains the CM-EP4 knockout (EP4 f/f -α-MyHC Cre+ ) or CF-EP4 knockout (EP4 f/f -S100A4 Cre+ ) mice. The mice of both genders are subcutaneously injected with ISO (5 mg kg −1 day −1 ) for 7 days. Compared to the control mice, both EP4 f/f -α-MyHC Cre+ and EP4 f/f -S100A4 Cre+ mice show a significant improvement in cardiac diastolic function and fibrosis as assessed by echocardiography and histological staining, respectively. In the CMs, inhibition of EP4 suppresses ISO-induced TGF-β1 expression via blocking the cAMP/PKA pathway. In the CFs, inhibition of EP4 reversed TGF-β1-triggers production of ECM via preventing the formation of the TGF-β1/TGF-β receptor complex and blocks CF proliferation via suppressing the ERK1/2 pathway. Furthermore, double knockout of the CM- and CF-EP4 or administration of EP4 antagonist, grapiprant, markedly improves ISO-induced cardiac diastolic dysfunction and fibrosis. Collectively, this study demonstrates that both CM-EP4 and CF-EP4 contribute to β-adrenergic activation-induced cardiac fibrosis. Targeting EP4 may offer a novel therapeutic approach for cardiac fibrosis.}, archive = {J_ADVS}, author = {Hu Xu and Xiuhui Mao and Yali Wang and Chunhua Zhu and Bo Liang and Yihang Zhao and Mengfei Zhou and Lan Ye and Mengting Hong and Huishu Shao and Yashuo Wang and Haonan Li and Yinghui Qi and Yongliang Yang and Lihong Chen and Youfei Guan and Xiaoyan Zhang}, doi = {10.1002/advs.202413324}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413324}, shortjournal = {Adv. Sci.}, title = {Targeting the e prostanoid receptor EP4 mitigates cardiac fibrosis induced by β-adrenergic activation}, volume = {12}, year = {2025}, }
• (2025). Interactions between bacterivorous nematodes and bacteria reduce N2O emissions. ADVS, 12(12), 2413227. (www)

  @article{ , abstract = {Trophic interactions in micro-food webs, such as those between nematodes and their bacterial prey, affect nitrogen cycling in soils, potentially changing nitrous oxide (N 2 O) production and consumption. However, how nematode-mediated changes in soil bacterial community composition affect soil N 2 O emissions is largely unknown. Here, microcosm experiments are performed with the bacterial feeding nematode Protorhabditis to explore the potential of nematodes in regulating microbial communities and thereby soil N 2 O emissions. Removal of nematodes by defaunation resulted in increased N 2 O emissions, with the removal of Protorhabditis contributing most to this increase. Further, inoculation with Protorhabditis altered bacterial community composition and increased the relative abundance of Bacillus , and the abundance of the nosZ gene in soil. In vitro experiments indicated that Protorhabditis reinforce the reduction in N 2 O emissions by Bacillus due to suppressing competitors and producing bacteria growth stimulating substances such as betaine. The results indicate that interactions between nematodes and bacteria modify N 2 O emissions providing the perspective for the mitigation of greenhouse gas emissions via manipulating trophic interactions in soil.}, archive = {J_ADVS}, author = {Xu Xu and Xinling Wang and Ting Sun and Shanshan Liu and Menghui Dong and Yang Yue and Yi Min and Alexandre Jousset and Xian Xiao and Shuwei Liu and Stefan Geisen and Valentyna Krashevska and Qirong Shen and Stefan Scheu and Rong Li}, doi = {10.1002/advs.202413227}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413227}, shortjournal = {Adv. Sci.}, title = {Interactions between bacterivorous nematodes and bacteria reduce N2O emissions}, volume = {12}, year = {2025}, }
• (2025). Through-thickness electric field establishes complex molecular architectures for localized liquid secretion. ADVS, 12(12), 2413212. (www)

  @article{ , abstract = {Localized liquid secretion, being an important process in nature such as the secretion of tears or mucus, has been an attractive point in developing biomimetic materials. However, precise localization remains challenging due to the cohesive and mobile nature of liquids. In this paper, light-induced localized liquid secretion is demonstrated on the scale of tens of micrometers by a liquid crystal polymer coating with an alternating homeotropic-planar alignment. The light responsiveness is achieved by the incorporation of azobenzene derivative. The localization is achieved by applying regional through-thickness electric fields to the monomeric liquid crystals before polymerization. The polymerized coating preserves both homeotropic and planar alignment. Upon actuation, the liquid can be locally secreted from the homeotropic region while suppressed in the planar area. This method allows precise control over various secretion patterns based on different pre-designed electrodes, which paves the way for the development of responsive devices in a multitude of fields, such as targeted drug delivery, tissue engineering, and microfluidic devices.}, archive = {J_ADVS}, author = {Dongyu Zhang and Julia Nuijten and Jacques Peixoto and Danqing Liu}, doi = {10.1002/advs.202413212}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413212}, shortjournal = {Adv. Sci.}, title = {Through-thickness electric field establishes complex molecular architectures for localized liquid secretion}, volume = {12}, year = {2025}, }
• (2025). Alkali induction strategy for artificial photosynthesis of hydrogen by TiO2 heterophase homojunctions. ADVS, 12(12), 2413069. (www)

  @article{ , abstract = {The robust separation and utilization of photogenerated electrons-holes (e − -h + ) are key in accelerating redox reactions. Unlike traditional heterojunction photocatalysts, homojunction features different energy bandgaps with interchangeable compositions that can significantly trigger charge carrier dynamics, but their precise construction remains an ongoing challenge owing to quick lattice-level modulations. Herein, TiO 2 -based homojunction (HT M-OH ) holding dissimilar yet discernible crystalline phases (anatase and rutile) are rationally constructed by a straightforward alkali-induced strategy which enables controllable lattice-transition/orientation. The resulting HT M-OH exhibits speedy separation and well-guided flow of e − -h + over redox sites with extended carrier lifetime, leading to high-rate hydrogen generation (HER, 34.35 mmol g −1 h −1 ) under simulated sunlight. Moreover, a self-made thin film of HT M-OH indicates a notable scale-up potential under real-time sunlight. This work furnishes a new non-complex homojunction strategy for speeding charge carrier kinetics, credibly extendable to a diverse range of catalysts and applications.}, archive = {J_ADVS}, author = {Minghua Xu and Xiaowen Ruan and Malik Zeeshan Shahid and Depeng Meng and Guozhen Fang and Chunsheng Ding and Wei Zhang and Jing Leng and Songcan Wang and Sai Kishore Ravi and Xiaoqiang Cui}, doi = {10.1002/advs.202413069}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413069}, shortjournal = {Adv. Sci.}, title = {Alkali induction strategy for artificial photosynthesis of hydrogen by TiO2 heterophase homojunctions}, volume = {12}, year = {2025}, }
• (2025). Structural colors go active. ADVS, 12(12), 2413027. (www)

  @article{ , abstract = {Structural colors find wide applications for color printing, intelligent display, filtering imaging, etc., owing to their benefits, including high resolution, stable properties, and dynamic tunability. This review first illustrates the mechanisms of structural color generation, such as surface plasmon resonances, localized surface plasmon resonances, Fabry-Perot resonances, Mie resonances, etc. It then proposes the recent technological strategies employed to realize dynamic structural colors. The integration of structural colors with functional materials like phase-change, along with the development of color dynamic control mechanisms such as microfluidic chips, micro-electro-mechanical system drivers, and microheaters, represents key approaches for spectrum regulation. Furthermore, the review assesses the performance, advantages, and limitations of various technologies for dynamic structural colors. Finally, this review concluded with a section on the future challenges and prospects in large-area fabrication, practical applications, and performance improvement. It explains the current typical applications, including smart windows, adaptive camouflage, sensors, etc., and explores the processing methods that can achieve large-area, high-fidelity preparation of structural colors, such as nanoimprint, deep ultraviolet lithography, immersion lithography, laser printing, etc. This field promises advancements in high-density data storage, information encryption, and broader market applications.}, archive = {J_ADVS}, author = {Xinting Li and Jiancun Zhao and Junyi Yang and Yihui Huo and Yiting Yu}, doi = {10.1002/advs.202413027}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2413027}, shortjournal = {Adv. Sci.}, title = {Structural colors go active}, volume = {12}, year = {2025}, }
• (2025). Unrevealing the interaction between electrode degradation and bubble behaviors in an anion exchange membrane water electrolyzer. ADVS, 12(12), 2412962. (www)

  @article{ , abstract = {Stainless steel felt has been employed in AEMWE as a combination of oxygen evolution reaction (OER) electrocatalysts and porous transport layers, which are not only easy to prepare but also have excellent OER activity under alkaline conditions. However, by realizing detailed electrochemical analysis and multi-scale visualization of the bubble behaviors, it is found that the combined effect of chemical and electrochemical corrosion led to the constant accumulation of metal oxides on the stainless steel fiber surface post-durability compared to the slow-growing hydroxides after initial activation. Moreover, the rougher fiber surface morphology and weaken hydrophilicity cause the adjacent bubbles are slower to detach from the electrode and are more likely to fusion. The measured diameter of bubbles leaving the electrode almost doubles, while the total number of bubbles decreases by about two-thirds, causing the increase of plug flow in the flow field and deteriorating the performance and long-term stability of AEMWE.}, archive = {J_ADVS}, author = {Lizhen Wu and Qing Wang and Shu Yuan and Xiaohan Mei and Qian Wang and Xiaohong Zou and Kouer Zhang and Xiaoyu Huo and Xingyi Shi and Zhefei Pan and Xiaohui Yan and Liang An}, doi = {10.1002/advs.202412962}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412962}, shortjournal = {Adv. Sci.}, title = {Unrevealing the interaction between electrode degradation and bubble behaviors in an anion exchange membrane water electrolyzer}, volume = {12}, year = {2025}, }
• (2025). Quercetin-driven akkermansia muciniphila alleviates obesity by modulating bile acid metabolism via an ILA/m6A/CYP8B1 signaling. ADVS, 12(12), 2412865. (www)

  @article{ , abstract = {Global health is increasingly challenged by the growing prevalence of obesity and its associated complications. Quercetin, one of the most important dietary flavonoids, is being explored as an effective therapy for obesity with its mechanism remains understudied. Here in this study, it is demonstrated that quercetin intervention significantly reverses obesity-related phenotypes through reshaping the overall structure of microbiota, especially boosting colonization of the beneficial gut commensal Akkermansia muciniphila ( A. muciniphila ). Enrichment of A. muciniphila leads to generate more indole-3-lactic acid (ILA) to upregulate the expression of 12α-hydroxylase (CYP8B1) via fat mass and obesity-associated protein (FTO)/ N 6 -methyladenosine (m 6 A)/YTHDF2 manner, thereby facilitating cholesterol converts to cholic acid (CA). CA in turn drastically suppresses lipid accumulation via activating the farnesoid X receptor (FXR) in adipose tissue. This work introduces a novel therapeutic target for addressing obesity and expands upon the current limited understanding of the mediator function of m 6 A modifications in microorganism-influenced bile acid (BA) metabolism.}, archive = {J_ADVS}, author = {Jiaqi Liu and Youhua Liu and Chaoqun Huang and Chuan He and Tongyudan Yang and Ruiti Ren and Zimeng Xin and Xinxia Wang}, doi = {10.1002/advs.202412865}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412865}, shortjournal = {Adv. Sci.}, title = {Quercetin-driven akkermansia muciniphila alleviates obesity by modulating bile acid metabolism via an ILA/m6A/CYP8B1 signaling}, volume = {12}, year = {2025}, }
• (2025). Evolutionary-distinct viral proteins subvert rice broad-spectrum antiviral immunity mediated by the RAV15-MYC2 module. ADVS, 12(12), 2412835. (www)

  @article{ , abstract = {A variety of plant viruses employ different virulence strategies to achieve successful infection, resulting in abnormal plant development. However, the common pathogenicity of distinct viruses has rarely been studied. Here, it is shown that a plant-specific RAV-type transcription factor, OsRAV15, is specifically targeted by several distinct viral proteins for facilitating viral infection. OsRAV15 is found to activate jasmonic acid (JA)-mediated broad-spectrum antiviral immunity by physically associating with JA signaling essential components OsMYC2-OsJAZ complex. To facilitate viral infection, evolutionarily distinct viral proteins encoded by diverse rice viruses generally disrupt the OsRAV15-OsMYC2 complex to attenuate activation of JA signaling. Together, the results reveal a common counter-defense strategy used by different viruses to suppress the OsRAV15-OsMYC2 module that plays a vital role in fine-tuning JA-mediated antiviral defense.}, archive = {J_ADVS}, author = {Hehong Zhang and Chaorui Huang and Chenfei Gao and Wenkai Yan and Weiqi Song and Xiaodi Hu and Lulu Li and Zhongyan Wei and Yanjun Li and Jianping Chen and Zongtao Sun}, doi = {10.1002/advs.202412835}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412835}, shortjournal = {Adv. Sci.}, title = {Evolutionary-distinct viral proteins subvert rice broad-spectrum antiviral immunity mediated by the RAV15-MYC2 module}, volume = {12}, year = {2025}, }
• (2025). Dislocation-driven formation of oriented macroperiodic metastructures of curved single crystal lattices in glass. ADVS, 12(12), 2412833. (www)

  @article{ , abstract = {Single crystals fabricated in glass by localized heating can develop uniquely deformed lattices stabilized by the surrounding amorphous medium. The development of lattice curvature appears to be intrinsic to the crystal growth process in some systems, while the result of the locally changing crystallography in others. In this work, a model laser-fabricated rotating lattice Sb 2 S 3 crystal grown in stoichiometric glass is used to demonstrate fabrication of novel macroperiodic metastructures that utilize intrinsic lattice curvature superimposed with subtle crystallographic influences. The limited availability of slip systems drives the lattice curvature magnitude to vary with crystal growth direction, maximizing for lattices aligned with the predominant Burgers vector along with corresponding increases in dislocation density. Misaligned lattice orientations form smaller secondary lattice curvatures arising from misaligned Burgers vectors with further elastic contributions. Over extended crystal growth, these secondary components align the lattice to rotate about either the <001> or <010> crystal axes forming repeating metastructures of lattice orientation with periodicity 20–160 microns in length. The mechanistic approach used in this work may be expanded to other systems with known slip systems to better understand and design macroperiodic metastructures.}, archive = {J_ADVS}, author = {Evan J. Musterman and Volkmar Dierolf and Himanshu Jain}, doi = {10.1002/advs.202412833}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412833}, shortjournal = {Adv. Sci.}, title = {Dislocation-driven formation of oriented macroperiodic metastructures of curved single crystal lattices in glass}, volume = {12}, year = {2025}, }
• (2025). Facet-dependent cold welding of au nanorods revealed by liquid cell transmission electron microscopy. ADVS, 12(12), 2412779. (www)

  @article{ , abstract = {Cold welding of metals at the nanoscale has been demonstrated to play a significant role in bottom-up manufacturing and self-healing processes of nanostructures and nanodevices. However, the welding mechanism at the nanoscale is not well understood. In this study, a comprehensive demonstration of the cold welding process of gold nanorods with different modes is presented through in situ liquid cell transmission electron microscopy. The experimental results and molecular dynamics simulations reveal that the nanorods are welded through the facet-dependent atomic surface diffusion and rearrangement along {100} facets. The density functional theory calculations indicate that the preferred coalescence of two {100} surfaces is thermodynamically favorable. Unlike the prevalent “oriented attachment” in the nanoparticle coalescence, the misalignment of nanorod orientations and local stresses can induce grain boundaries and stacking faults in the welded interface.}, archive = {J_ADVS}, author = {Wen Wang and Dongxing Song and Fangjie Meng and Sufeng Fan and Ran Cai and Shaobo Cheng and Chongxin Shan and Tao Xu and Haimei Zheng and Litao Sun}, doi = {10.1002/advs.202412779}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412779}, shortjournal = {Adv. Sci.}, title = {Facet-dependent cold welding of au nanorods revealed by liquid cell transmission electron microscopy}, volume = {12}, year = {2025}, }
• (2025). Reaction pathway differentiation enabled fingerprinting signal for single nucleotide variant detection. ADVS, 12(12), 2412680. (www)

  @article{ , abstract = {Accurate identification of single-nucleotide variants (SNVs) is paramount for disease diagnosis. Despite the facile design of DNA hybridization probes, their limited specificity poses challenges in clinical applications. Here, a differential reaction pathway probe (DRPP) based on a dynamic DNA reaction network is presented. DRPP leverages differences in reaction intermediate concentrations between SNV and WT groups, directing them into distinct reaction pathways. This generates a strong pulse-like signal for SNV and a weak unidirectional increase signal for wild-type (WT). Through the application of machine learning to fluorescence kinetic data analysis, the classification of SNV and WT signals is automated with an accuracy of 99.6%, significantly exceeding the 80.7% accuracy of conventional methods. Additionally, sensitivity for variant allele frequency (VAF) is enhanced down to 0.1%, representing a ten-fold improvement over conventional approaches. DRPP accurately identified D614G and N501Y SNVs in the S gene of SARS-CoV-2 variants in patient swab samples with accuracy over 99% (n = 82). It determined the VAF of ovarian cancer-related mutations KRAS-G12R , NRAS-G12C , and BRAF-V600E in both tissue and blood samples (n = 77), discriminating cancer patients and healthy individuals with significant difference ( p < 0.001). The potential integration of DRPP into clinical diagnostics, along with rapid amplification techniques, holds promise for early disease diagnostics and personalized diagnostics.}, archive = {J_ADVS}, author = {Huixiao Yang and Linghao Zhang and Xinmiao Kang and Yunpei Si and Ping Song and Xin Su}, doi = {10.1002/advs.202412680}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412680}, shortjournal = {Adv. Sci.}, title = {Reaction pathway differentiation enabled fingerprinting signal for single nucleotide variant detection}, volume = {12}, year = {2025}, }
• (2025). Design principles from natural olfaction for electronic noses. ADVS, 12(12), 2412669. (www)

  @article{ , abstract = {Natural olfactory systems possess remarkable sensitivity and precision beyond what is currently achievable by engineered gas sensors. Unlike their artificial counterparts, noses are capable of distinguishing scents associated with mixtures of volatile molecules in complex, typically fluctuating environments and can adapt to changes. This perspective examines the multifaceted biological principles that provide olfactory systems their discriminatory prowess, and how these ideas can be ported to the design of electronic noses for substantial improvements in performance across metrics such as sensitivity and ability to speciate chemical mixtures. The topics examined herein include the fluid dynamics of odorants in natural channels; specificity and kinetics of odorant interactions with olfactory receptors and mucus linings; complex signal processing that spatiotemporally encodes physicochemical properties of odorants; active sampling techniques, like biological sniffing and nose repositioning; biological priming; and molecular chaperoning. Each of these components of natural olfactory systems are systmatically investigated, as to how they have been or can be applied to electronic noses. While not all artificial sensors can employ these strategies simultaneously, integrating a subset of bioinspired principles can address issues like sensitivity, drift, and poor selectivity, offering advancements in many sectors such as environmental monitoring, industrial safety, and disease diagnostics.}, archive = {J_ADVS}, author = {Haritosh Patel and Vicente Garrido Portilla and Anna V. Shneidman and Jacopo Movilli and Jack Alvarenga and Christophe Dupré and Michael Aizenberg and Venkatesh N. Murthy and Alexander Tropsha and Joanna Aizenberg}, doi = {10.1002/advs.202412669}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412669}, shortjournal = {Adv. Sci.}, title = {Design principles from natural olfaction for electronic noses}, volume = {12}, year = {2025}, }
• (2025). Osteoblast-derived mitochondria formulated with cationic liposome guide mesenchymal stem cells into osteogenic differentiation. ADVS, 12(12), 2412621. (www)

  @article{ , abstract = {While mitochondria are known to be essential for intracellular energy production and overall function, emerging evidence highlights their role in influencing cell behavior through mitochondrial transfer. This phenomenon provides a potential basis for the development of treatment strategies for tissue damage and degeneration. This study aims to evaluate whether mitochondria isolated from osteoblasts can promote osteogenic differentiation in mesenchymal stem cells (MSCs). Mitochondria from MSCs, which primarily utilize glycolysis, are compared with those from MG63 cells, which depend on oxidative phosphorylation. Mitochondria from both cell types are then encapsulated in cationic liposomes and transferred to MSCs, and their impact on differentiation is assessed. Mitochondria delivery from MG63 cells to MSCs grown in both two- and three-dimensional cultures results in increased expression of osteogenic markers, including Runt-related transcription factor 2, Osterix, and Osteopontin, and upregulation of genes involved in Bone morphogenetic protein 2 signaling and calcium import. This is accompanied by increased calcium influx and regulated by the Wnt/β-catenin signaling pathway. Transplantation of spheroids containing MSCs with MG63-derived mitochondria in bone defect animal models improves bone regeneration. The results suggest that delivery of MG63-derived mitochondria effectively guides MSCs toward osteogenesis, paving the way for the development of mitochondria-transplantation therapies.}, archive = {J_ADVS}, author = {Hye-Ryoung Kim and Seonjeong Woo and Hui Bang Cho and Sujeong Lee and Chae Won Cho and Ji-In Park and Seulki Youn and Gyuwon So and Sumin Kang and Sohyun Hwang and Hye Jin Kim and Keun-Hong Park}, doi = {10.1002/advs.202412621}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412621}, shortjournal = {Adv. Sci.}, title = {Osteoblast-derived mitochondria formulated with cationic liposome guide mesenchymal stem cells into osteogenic differentiation}, volume = {12}, year = {2025}, }
• (2025). Radiotherapy-associated cellular senescence and EMT alterations contribute to distinct disease relapse patterns in locally advanced cervical cancer. ADVS, 12(12), 2412574. (www)

  @article{ , abstract = {A notable number of locally advanced cervical carcinoma (LACC) patients experience local or distant disease relapse following radiotherapy. The contribution of tumor microenvironment (TME) to tumor recurrence at different sites remains unclear. Here, single-nucleus RNA sequencing data from 28 pre- and on-treatment LACC samples from patients with different disease relapse patterns is analyzed. The findings revealed opposing alterations in the expression levels of the cellular senescence pathway after radiotherapy in patients with local and distant relapses. In contrast, an increase in the expression of the epithelial-mesenchymal transition module after radiotherapy in both relapse groups is observed. Cell–cell interactions, drug-target expression analyses in malignant cells after radiation, and multiplex immunofluorescence of tumor tissue identified interleukin-1 receptor type I (IL1R1) as a potential therapeutic target. It is demonstrated that combining the IL1R1 inhibitor anakinra with radiation can mitigate the effects of radiation on tumor cells. This study highlights the distinct roles of cellular senescence and EMT in tumor recurrence.}, archive = {J_ADVS}, author = {Lei Zhang and Jun Ma and Jun Zhang and Minjie Hu and Jinlin Cheng and Bin Hu and Junjun Zhou and Di Zhou and Yongrui Bai and Xiumei Ma and Jianming Tang and Haiyan Chen and Ying Jing}, doi = {10.1002/advs.202412574}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412574}, shortjournal = {Adv. Sci.}, title = {Radiotherapy-associated cellular senescence and EMT alterations contribute to distinct disease relapse patterns in locally advanced cervical cancer}, volume = {12}, year = {2025}, }
• (2025). GNE-317 reverses MSN-mediated proneural-to-mesenchymal transition and suppresses chemoradiotherapy resistance in glioblastoma via PI3K/mTOR. ADVS, 12(12), 2412517. (www)

  @article{ , abstract = {Glioblastoma (GBM) resistance to chemoradiotherapy is a major factor contributing to poor treatment outcomes. This resistance markedly affects the effectiveness of surgery combined with chemoradiotherapy and leads to post-surgical tumor recurrence. Therefore, exploring the mechanisms underlying chemoradiotherapy resistance in GBM is crucial for understanding its progression and improving therapeutic options. This study found that moesin (MSN) acts as a key promotor of chemoradiotherapy resistance in glioma stem cells (GSCs), enhancing their proliferation and stemness maintenance. Mechanistically, MSN activates the downstream PI3K/mTOR signaling pathway, driving the proneural-to-mesenchymal transition (PMT) in GSCs. This process enhances the repair of DNA damage caused by radiotherapy (RT) and temozolomide (TMZ), thereby increasing the resistance of GSCs to chemoradiotherapy. Additionally, GNE-317, a small molecule drug capable of crossing the blood-brain barrier, specifically inhibits MSN and suppresses the activation of downstream PI3K/mTOR signaling. Importantly, the combination of GNE-317 with RT and TMZ exhibits a strong synergistic effect both in vivo and in vitro, achieving better efficacy compared to the traditional combination of RT and TMZ. This study not only advances understanding of the mechanisms underlying chemoradiotherapy resistance in GBM but also provides a promising new approach for enhancing treatment outcomes.}, archive = {J_ADVS}, author = {Yong-Chang Yang and Xing-Yu Jin and Ling-Ling Yang and Xing Xu and Yang Xie and Yi-Ding Ai and Xin-Chao Li and Ye-Cheng Ma and Cheng-Long Xu and Qi Li and Xiang-Lian Ge and Tai-Long Yi and Tao Jiang and Xiao-Guang Wang and Ying-Zhe Piao and Xun Jin}, doi = {10.1002/advs.202412517}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412517}, shortjournal = {Adv. Sci.}, title = {GNE-317 reverses MSN-mediated proneural-to-mesenchymal transition and suppresses chemoradiotherapy resistance in glioblastoma via PI3K/mTOR}, volume = {12}, year = {2025}, }
• (2025). Electropositive magnetic fluorescent nanoprobe-mediated immunochromatographic assay for the ultrasensitive and simultaneous detection of bacteria. ADVS, 12(12), 2412421. (www)

  @article{ , abstract = {Immunochromatographic assays (ICAs) provide simple and rapid strategies for bacterial diagnosis but still suffer from the problems of low sensitivity and high dependency on paired antibodies. Herein, the broad-spectrum capture and detection capability of the antibody-free electropositive nanoprobe are clarified for bacteria for the first time and an ultrasensitive fluorescent ICA platform is constructed for the simultaneous diagnosis of multiple pathogens. A magnetic multilayer quantum dot nanocomposite with an amino-embedded SiO 2 shell (MagMQD@Si + ) is designed to enrich bacteria from solutions effectively, offer high luminescence, and reduce background signals on test strips, thus greatly improving the sensitivity and stability of ICA technique for pathogen. The superior performance of the MagMQD@Si + -based ICA through the multiplex detection of three common pathogens is demonstrated, namely, Pseudomonas aeruginosa , Streptococcus pneumoniae , and Salmonella typhimurium , showing that this ICA possesses high sensitivity (8–40 cells mL −1 ), good reproducibility (relative standard deviation < 5.4%), and high specificity for the three target bacteria. The clinical utility of the proposed method is verified through the detection of 30 real sputum samples from patients with bacterial respiratory infections, revealing that the MagMQD@Si + -based ICA has massive potential as a powerful inspection tool for the rapid, sensitive, and ultrasensitive diagnosis of bacterial infections. [Correction added on 29 January 2025, after first online publication: Streptococcus typhi was corrected to Salmonella typhimurium .]}, archive = {J_ADVS}, author = {Jiaxuan Li and Zhengkang Li and Bingjie Wang and Qing Yu and Ting Wu and Chongwen Wang and Bing Gu}, doi = {10.1002/advs.202412421}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412421}, shortjournal = {Adv. Sci.}, title = {Electropositive magnetic fluorescent nanoprobe-mediated immunochromatographic assay for the ultrasensitive and simultaneous detection of bacteria}, volume = {12}, year = {2025}, }
• (2025). Unraveling the microenvironment and the pathogenic axis of HIF-1α–Visfatin–Fibrosis in autoimmune pancreatitis using a single-cell atlas. ADVS, 12(12), 2412282. (www)

  @article{ , abstract = {Autoimmune pancreatitis (AIP) is identified as a severe chronic immune-related disorder in pancreas, including two subtypes. In this study, pancreatic lesions in patients diagnosed as either type 1 AIP or type 2 AIP are examined, and these patients’ peripheral blood at single-cell level. Furthermore, flow cytometry, immunofluorescence, and functional assays are performed to verify the identified cell subtypes. In type 1 AIP, there is a notable increase in the amount of B cells and plasma cells, and IgG4+ plasma cells are key pathogenic cells of AIP. The differentiation path of naïve-stage B cells into IgG4+ produced plasma cells is observed, and an increased amount of T helper cells and T follicular helper (Tfh) cells. This study also reveals that HIF-1α, an activated transcriptional factor, can directly bind to promoter site of NAMPT, promoting higher levels of visfatin production in HIF1A+ classical monocytes. Pancreatic stellate cells can be activated by extracellular visfatin and promote the development of fibrotic response in pancreatic lesions across both AIP subtypes. The current findings shed light on the exploration of dynamic alterations in peripheral blood cells and cell subgroups in pancreatic lesions of AIP, while elucidating a pathogenic cell subset and potential fibrosis mechanism of AIP.}, archive = {J_ADVS}, author = {Deyu Zhang and Congjia Ma and Zhen Wang and Yanfang Liu and Zaoqu Liu and Wanshun Li and Yue Liu and Chang Wu and Liqi Sun and Fei Jiang and Hui Jiang and Xiaoju Su and Lisi Peng and Jiayu Li and Xinyue Wang and Hua Yin and Dongling Wan and Yuyan Zhou and Xiaorong Tian and Shiyu Li and Zhendong Jin and Baoan Ji and Zhaoshen Li and Haojie Huang}, doi = {10.1002/advs.202412282}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412282}, shortjournal = {Adv. Sci.}, title = {Unraveling the microenvironment and the pathogenic axis of HIF-1α–Visfatin–Fibrosis in autoimmune pancreatitis using a single-cell atlas}, volume = {12}, year = {2025}, }
• (2025). Quorum sensing coordinates carbon and nitrogen metabolism to optimize public goods production in pseudomonas fluorescens 2P24. ADVS, 12(12), 2412224. (www)

  @article{ , abstract = {The coordination of public and private goods production is essential for bacterial adaptation to environmental changes. Quorum sensing (QS) regulates this balance by mediating the trade-off between the communal benefits of “public goods,” such as siderophores and antibiotics, and the individual metabolic needs fulfilled by “private goods,” such as intracellular metabolites utilized for growth and survival. Pseudomonas fluorescens 2P24 harbors a LasI/LasR-type QS system, MupI/MupR, which regulates mupirocin production through signaling molecules. This study explores how QS coordinates carbon and nitrogen metabolism to optimize the production of key secondary metabolites, including 2,4-diacetylphloroglucinol (2,4-DAPG), mupirocin, and siderophores, which serve as public goods. Loss of QS disrupts this balance by enhancing the Krebs cycle, denitrification, pyruvate anaplerosis, and ammonium assimilation, lead to halted 2,4-DAPG and mupirocin synthesis and increased siderophore production. In the absence of QS, elevated siderophore production compensates for iron acquisition, ensuring rapid cellular growth. Under nutrient-limited or high cell density conditions, MupR regulates carbon and nitrogen fluxes to sustain public goods production. These findings highlight QS as a key environmental sensor that fine-tunes resource allocation, bacterial fitness, and adaptation to ecological and nutritional conditions, suggesting the potential for QS-targeted approaches to enhance antibiotic production and agricultural sustainability.}, archive = {J_ADVS}, author = {Jie Li and Mengxue Nie and Hongguang Ma and Xuanying Tao and Yanxia Sun and Xinyue Tu and Pingping Zhang and Li-Qun Zhang and Rong Jia and Yong-Xing He and Nannan Zhang and Honghua Ge}, doi = {10.1002/advs.202412224}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412224}, shortjournal = {Adv. Sci.}, title = {Quorum sensing coordinates carbon and nitrogen metabolism to optimize public goods production in pseudomonas fluorescens 2P24}, volume = {12}, year = {2025}, }
• (2025). Cardiomyocyte foxp1-specific deletion promotes post-injury heart regeneration via targeting usp20-HIF1ɑ-hand1 signaling pathway. ADVS, 12(12), 2412124. (www)

  @article{ , abstract = {The adult mammalian heart has limited regenerative capacity to replace lost tissue after a major injury. Forkhead box P1 (Foxp1) regulates embryonic cardiomyocyte proliferation and heart development. However, whether Foxp1 participates in postnatal-injury cardiomyocyte proliferation and heart regeneration remains unclear. This study demonstrates that Foxp1 is downregulated at border zone cardiomyocytes of both neonatal apical resection and adult myocardial infarction. Analysis of the Single-cell transcriptome database reveals reduced Foxp1 expression in the cardiomyocyte population with high regenerative capacity. Cardiomyocyte-Foxp1 loss-of-function significantly promotes, whereas cardiomyocytes-Foxp1 gain-of-function suppresses cardiomyocyte proliferation. Mechanistically, Foxp1 directly regulates ubiquitin specific peptidase 20 (USP20), a de-ubiquitinase that prevents hypoxia inducible factor 1ɑ (HIF1α) degradation. Thus, Foxp1 regulates HIF1α and downstream heart and neural crest derivatives expressed 1 (Hand1) to control the cardiomyocyte proliferation via metabolic transition from fatty acid oxidation to glycolysis. Finally, cardiac type troponin T2 (cTnT)-promoter-driven adeno-associated virus 9 (AAV9) for Hand1 induction in cardiomyocytes significantly promoted cardiac regeneration and functional recovery. These findings may provide novel molecular strategies to promote heart regeneration and therapeutic interventions for heart failure.}, archive = {J_ADVS}, author = {Yanfang Wang and Xiaoyu Wang and Ji Fang and Xiaoli Chen and Teng Xu and Tao Zhuang and Sheng Peng and Wenzhen Bao and Wenrun Wu and Yushi Lu and Haikun Wang and Brian Tomlinson and Paul Chan and Shougang Zhuang and Qi Zhang and Lin Zhang and Zhongmin Liu and Jingjiang Pi and Yuzhen Zhang and Jie Liu}, doi = {10.1002/advs.202412124}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412124}, shortjournal = {Adv. Sci.}, title = {Cardiomyocyte foxp1-specific deletion promotes post-injury heart regeneration via targeting usp20-HIF1ɑ-hand1 signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Mitochondrial amount determines doxorubicin-induced cardiotoxicity in cardiomyocytes. ADVS, 12(12), 2412017. (www)

  @article{ , abstract = {Doxorubicin, an anthracycline commonly used for treating cancer patients, is known for its cardiotoxic side-effects. Although dose-dependent, but susceptibility remains variable among patients, and childhood-exposure-adult-onset remains challenging. Besides topoisomerase toxicity, Doxorubicin is also toxic to the mitochondria yet the underlying late onset mechanism remains elusive. Here, it is observed that the mitochondrial copy number in PBMCs of patients treated with anthracycline chemotherapy is negatively correlated with the change in plasma BNP levels after treatment. Isogenic hiPSC-CMs are generated with high, norm, and low mitochondrial copy numbers using mitochondrial transplantation and the YFP-Parkin system. Remarkably, lower mitochondria copy number translates to lower IC 50 , suggesting increased susceptibility. Mitochondria supplementation by intramyocardial injection prevents doxorubicin induced heart failure. Mechanistically, doxorubicin treatment leads to mPTP opening and mitochondrial DNA (mtDNA) leakage. This mtDNA leakage event activates the cGAS-STING pathway and drives inflammation and myocardial senescence. Cardiomyocyte-specific knockout of Sting (Myh6-Cre/Sting flox/flox ; Sting CKO ) and over expression of mitochondrial tagged DNase1 in mice partially rescue doxorubicin-induced cardiac dysfunction. In conclusion, the work establishes a negative correlation between cardiomyocyte mitochondrial copy number and doxorubicin toxicity. Molecularly, it is demonstrated that mtDNA leakage activates cGAS-STING pathway and accelerates myocardial dysfunction. These insights offer new co-administration strategies for cancer patients.}, archive = {J_ADVS}, author = {Weiyao Xiong and Bin Li and Jianan Pan and Dongjiu Li and Haihua Yuan and Xin Wan and Yanjie Zhang and Lijun Fu and Junfeng Zhang and Ming Lei and Alex Chia Yu Chang}, doi = {10.1002/advs.202412017}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2412017}, shortjournal = {Adv. Sci.}, title = {Mitochondrial amount determines doxorubicin-induced cardiotoxicity in cardiomyocytes}, volume = {12}, year = {2025}, }
• (2025). DNA polymerase IV dinB favors the adaptive fitness of mcr-carrying bacteria through a negative feedback regulatory mechanism. ADVS, 12(12), 2411994. (www)

  @article{ , abstract = {The plasmid-borne resistance gene mcr drastically undermines the effectiveness of colistin, posing a substantial threat to public health. Although several key plasmid elements that balance mcr-1 persistence and bacterial growth are identified, the regulatory interactions between mcr-1 and host bacteria remain poorly understood. Using a genome-wide CRISPRi crRNA library, it is identified that DNA polymerase IV, dinB , is essential for controlling the fitness cost associated with mcr-1 in Escherichia coli . The absence of dinB operon enhances mcr-1 -mediated colistin resistance but simultaneously compromises bacterial growth and competitiveness. Meanwhile, dinB deficiency mitigates inflammatory response in RAW267.4 cells and enhances bacterial colonization in murine tissues. Further investigation reveals that mcr-1 actively upregulates dinB expression, with the increased reactive oxygen species induced by mcr-1 being crucial for this activation.   These findings suggest that dinB modulates mcr expression and bacterial fitness via a negative feedback regulatory mechanism. Leveraging this regulatory relationship, a Toxin-Intein is engineered under the control of dinB promoter to selectively target and kill mcr -positive E. coli both in vitro and in vivo. Overall, the work uncovers a novel adaptive mechanism underlying mcr persistence and provides a precise antimicrobial strategy to combat antibiotic-resistant pathogens.}, archive = {J_ADVS}, author = {Haijie Zhang and Xia Xiao and Chenlong Wang and Yurong Zhao and Bo Chen and Xinyuan Ji and Lina Gu and Jie Wang and Zhiqiang Wang and Yuan Liu}, doi = {10.1002/advs.202411994}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411994}, shortjournal = {Adv. Sci.}, title = {DNA polymerase IV dinB favors the adaptive fitness of mcr-carrying bacteria through a negative feedback regulatory mechanism}, volume = {12}, year = {2025}, }
• (2025). RNASET2 deficiency induces hepatocellular carcinoma metastasis through cholesterol-triggered MET activation. ADVS, 12(12), 2411888. (www)

  @article{ , abstract = {Metastasis remains a significant challenge in the treatment of hepatocellular carcinoma (HCC). The role of ribonuclease T2 (RNASET2) in HCC is still uncertain, although it has been reported to have contradictory effects on some cancers. Here, it is demonstrated that RNASET2 knockout leads to significant accumulation of cholesterol, which in turn promotes MET-mediated HCC metastasis. Mechanistically, the absence of RNASET2 hinders the degradation of RNA into uridine, thereby reducing the conversion to UTP. This reduction restrains glucuronate metabolism and the expression of the related enzyme UDP-glucuronosyltransferase (UGT)1A1, ultimately resulting in the accumulation of cholesterol due to decreased formation of glucuronidated-bile acids. The administration of cholesterol induces the migration and invasion of HCC cells through MET (mesenchymal-epithelial transition factor) activation. However, the deficiency of RNASET2-induced HCC metastasis can be reversed by blocking MET with shRNA or savolitinib. The study identifies RNASET2 as a key regulator that coordinates RNA, glucuronate, and cholesterol metabolism. Its deficiency drives HCC metastasis through cholesterol-triggered MET activation. These findings highlight the potential of targeting RNASET2 and MET in improving the prognosis of HCC.}, archive = {J_ADVS}, author = {Yanquan Xu and Yu Chen and Jiangang Zhang and Jingchun Wang and Shuai Yang and Huakan Zhao and Lei Wu and Juan Lei and Yu Zhou and Jin Peng and Lu Jiang and Qian Chen and Rong Xin and Jianyun Zhou and Yongsheng Li}, doi = {10.1002/advs.202411888}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411888}, shortjournal = {Adv. Sci.}, title = {RNASET2 deficiency induces hepatocellular carcinoma metastasis through cholesterol-triggered MET activation}, volume = {12}, year = {2025}, }
• (2025). Experimental realization of on-chip surface acoustic wave metasurfaces at sub-GHz. ADVS, 12(12), 2411825. (www)

  @article{ , abstract = {Metasurfaces, consisting of subwavelength-thickness units with different wave responses, provide an innovative possible method to manipulate elastic and acoustic waves efficiently. The application of metasurfaces to manipulate on-chip surface acoustic wave (SAW) at sub-GHz frequencies requires further exploration since their wave functions are highly demanded in nanoelectromechanical systems (NEMS), sensing, communications, microfluid control and quantum processing. Here, the experimental realization of on-chip SAW metasurfaces is reported, consisting of gradient submicron niobium (Nb) rectangular pillars positioned on a 128°Y-cut lithium niobate (LiNbO 3 ) substrate that operate at hundreds of megahertz. The proposed SAW metasurfaces are able to manipulate transmitted SAW wavefront functions by designing on-demand pillar's profile distributions. Broadband subwavelength focusing effects as the typical functions of SAW metasurfaces are experimentally demonstrated. This study opens a door for realizing on-chip SAW metasurfaces for diverse potential applications at micro- and nanoscale.}, archive = {J_ADVS}, author = {Wan Wang and Maciej Baranski and Yabin Jin and Roland Salut and Djaffar Belharet and Jean-Michel Friedt and Yongdong Pan and Yanxun Xiang and Fu-zhen Xuan and Abdelkrim Khelif and Sarah Benchabane}, doi = {10.1002/advs.202411825}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411825}, shortjournal = {Adv. Sci.}, title = {Experimental realization of on-chip surface acoustic wave metasurfaces at sub-GHz}, volume = {12}, year = {2025}, }
• (2025). Targeting FDFT1 reduces cholesterol and bile acid production and delays hepatocellular carcinoma progression through the HNF4A/ALDOB/AKT1 axis. ADVS, 12(12), 2411719. (www)

  @article{ , abstract = {Targeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial. Herein, farnesyl-diphosphate farnesyltransferase 1 (FDFT1) is identified as a novel target for treating HCC and a potential alternative to statins. Twenty-three key genes in cholesterol biosynthesis are screened, and FDFT1 is identified via public databases (The Cancer Genome Atlas, International Cancer Genome Consortium and Gene Expression Omnibus). Clinical samples reveal that FDFT1 is highly expressed in HCC tissues, and this phenotype is strongly associated with a poor prognosis. Functionally, FDFT1 knockdown inhibits the proliferation and metastasis of HCC cells and suppresses hepatocarcinogenesis in vitro and in vivo, whereas FDFT1 overexpression promotes HCC cell proliferation and metastasis. Mechanistically, FDFT1 downregulation decreases cholesterol and bile acid levels and then increases hepatocyte nuclear factor 4 alpha (HNF4A) transcriptional activity. Experiments indicate that HNF4A combines with the promoter of aldolase B ( ALDOB) and promotes the ALDOB transcription and that ALDOB combines with AKT serine/threonine kinase 1 (AKT1) and inhibits AKT1 phosphorylation. Moreover, FDFT1 knockdown combined with AKT inhibitor (AZD5363) treatment shows remarkable therapeutic potential. FDFT1 inhibition reduces cholesterol and bile acid levels to delay HCC progression through the HNF4A/ALDOB/AKT1 axis. Thus, targeting FDFT1 may be a novel potential strategy for treating HCC.}, archive = {J_ADVS}, author = {Dong Cai and Guo-Chao Zhong and Xin Dai and Zhibo Zhao and Menglin Chen and Jiejun Hu and Zhenru Wu and Lve Cheng and Shengwei Li and Jianping Gong}, doi = {10.1002/advs.202411719}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411719}, shortjournal = {Adv. Sci.}, title = {Targeting FDFT1 reduces cholesterol and bile acid production and delays hepatocellular carcinoma progression through the HNF4A/ALDOB/AKT1 axis}, volume = {12}, year = {2025}, }
• (2025). CircMETTL6 suppresses ovarian cancer cell growth and metastasis through inhibition of GDF15 transcription by disrupting the NONO-POLR2A complex. ADVS, 12(12), 2411717. (www)

  @article{ , abstract = {Circular RNAs (circRNAs) are a distinctive class of non-coding RNAs with covalent closed-loop structure, lacking 5′ caps and 3′ poly(A) tails. These molecules are prevalent in eukaryotes and play key roles in cancer. Here, the function of a new circRNA, circMETTL6, in ovarian cancer is identified and investigated. The prognostic significance of circMETTL6 is assessed using RNA in situ hybridization. Functional studies involving circMETTL6 overexpression are performed both in vitro and in vivo. Mechanistic investigations are performed using RNA-seq, RNA pull-down, RNA immunoprecipitation, co-immunoprecipitation, chromatin immunoprecipitation, protein degradation assay and dual-luciferase reporter assays. circMETTL6 is significantly downregulated in ovarian cancer, and its lower expression correlates with worse prognosis. Overexpression of circMETTL6 significantly inhibited proliferation, migration, and invasion of ovarian cancer cell in vitro, as well as tumor growth and metastasis in vivo. Mechanistically, circMETTL6 recruited the non-POU domain containing octamer binding protein (NONO) by binding to its Coiled-coil domain and disrupted its binding with RNA polymerase II subunit A (POLR2A), and consequently inhibiting growth differentiation factor 15 (GDF15) transcription, thereby suppressing ovarian cancer progression. These findings establish circMETTL6 as a novel tumor suppressor in ovarian cancer. Targeting the circMETTL6/NONO/GDF15 axis presents a potential therapeutic avenue for ovarian cancer treatment.}, archive = {J_ADVS}, author = {Mengqian Yu and Mengting Wu and Tao Shen and Qiongzi Qiu and Aoran Luo and Jia Li and Xufan Li and Xiaodong Cheng and Bingjian Lu and Weiguo Lu and Pengyuan Liu and Yan Lu}, doi = {10.1002/advs.202411717}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411717}, shortjournal = {Adv. Sci.}, title = {CircMETTL6 suppresses ovarian cancer cell growth and metastasis through inhibition of GDF15 transcription by disrupting the NONO-POLR2A complex}, volume = {12}, year = {2025}, }
• (2025). Engineering yarrowia lipolytica to enhance the production of malonic acid via malonyl-CoA pathway at high titer. ADVS, 12(12), 2411665. (www)

  @article{ , abstract = {Malonic acid (MA) is a high-value-added chemical with significant applications in the polymers, pharmaceutical, and food industries. Microbial production of MA presents enzyme inefficiencies, competitive metabolic pathways, and dispersive carbon flux, which collectively limit its biosynthesis. Here, the non-conventional oleaginous yeast Yarrowia lipolytica is genetically engineered to enhance MA production. Initially, the malonyl-CoA pathway, comprising a malonyl-CoA hydrolase from Saccharomyces cerevisiae , is confirmed as the most efficient for MA production in Y. lipolytica . To further enhance MA production, two novel malonyl-CoA hydrolases exhibiting higher activity than the hydrolase from S. cerevisiae , are identified from Y. lipolytica and Fusarium oxysporum , respectively. The introduction of the malonyl-CoA hydrolase from F. oxysporum increases the MA titer to 6.3 g L −1 . Subsequently, advanced metabolic engineering strategies are performed to ensure a sufficient flux of the precursors acetyl-CoA and malonyl-CoA for MA production, resulting in a production of 13.8 g L −1 MA in shaking-flasks. Finally, by employing the fermentation conditions and feeding strategies, a maximum concentration of 63.6 g L −1 of MA is achieved at 156 h with a productivity of 0.41 g L −1 h −1 in fed-batch fermentation. This study provides a new way for engineering Y. lipolytica to enhance MA production at high titer.}, archive = {J_ADVS}, author = {Qun Yang and Mengzhen Tian and Ping Dong and Yunying Zhao and Yu Deng}, doi = {10.1002/advs.202411665}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411665}, shortjournal = {Adv. Sci.}, title = {Engineering yarrowia lipolytica to enhance the production of malonic acid via malonyl-CoA pathway at high titer}, volume = {12}, year = {2025}, }
• (2025). Integrating humidity-resistant and colorimetric COF-on-MOF sensors with artificial intelligence assisted data analysis for visualization of volatile organic compounds sensing. ADVS, 12(12), 2411621. (www)

  @article{ , abstract = {Direct visualization and monitoring of volatile organic compounds (VOCs) sensing processes via portable colorimetric sensors are highly desired but challenging targets. The key challenge resides in the development of efficient sensing systems with high sensitivity, selectivity, humidity resistance, and profuse color change. Herein, a strategy is reported for the direct visualization of VOCs sensing by mimicking human olfactory function and integrating colorimetric COF-on-MOF sensors with artificial intelligence (AI)-assisted data analysis techniques. The Dye@Zeolitic Imidazolate Framework@Covalent Organic Framework (Dye@ZIF-8@COF) sensor takes advantage of the highly porous structure of MOF core and hydrophobic nature of the COF shell, enabling highly sensitive colorimetric sensing of trace number of VOCs. The Dye@ZIF-8@COF sensor exhibits exceptional sensitivity to VOCs at sub-parts per million levels and demonstrates excellent humidity resistance (under 20–90% relative humidity), showing great promise for practical applications. Importantly, AI-assisted information fusion and perceptual analysis greatly promote the accuracy of the VOCs sensing processes, enabling direct visualization and classification of seven stages of matcha drying processes with a superior accuracy of 95.74%. This work paves the way for the direct visualization of sensing processes of VOCs via the integration of advanced humidity-resistant sensing materials and AI-assisted data analyzing techniques.}, archive = {J_ADVS}, author = {Qin Ouyang and Yanna Rong and Gaofan Xia and Quansheng Chen and Yujie Ma and Zhonghua Liu}, doi = {10.1002/advs.202411621}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411621}, shortjournal = {Adv. Sci.}, title = {Integrating humidity-resistant and colorimetric COF-on-MOF sensors with artificial intelligence assisted data analysis for visualization of volatile organic compounds sensing}, volume = {12}, year = {2025}, }
• (2025). Legged robot with tensegrity feature bionic knee joint. ADVS, 12(12), 2411351. (www)

  @article{ , abstract = {Legged robots, designed to emulate human functions, have greatly influenced numerous sectors. However, the focus on continuously improving the joint motors and control systems of existing legged robots not only increases costs and complicates maintenance but also results in failure to accurately mimic the functionality of the human skeletal‒muscular system. This study introduces a bionic legged robot structure that leverages the tensegrity principle, drawing inspiration from the human leg's structural morphology and kinematic mechanisms. By designing a system that distinguishes between rolling and sliding movements, the human knee's variable instantaneous center of rotation (ICR), is successfully replicated showcasing its capabilities in achieving gait resemblance and vibration absorption. The tensegrity unit's features, including remarkable deformability, self-recovery, and the four-bar mechanism's singular position characteristic, alongside a rope unlocking mechanism reminiscent of human muscles, facilitate in situ compliance–rigid–compliance transitions of the knee joint without the need for knee joint motors, relying solely on ground contact through the foot. This innovation overcomes the conventional dependency of legged robots on joint motors, as the system requires only a single DC motor positioned at the hip joint and a straightforward control program to seamlessly execute a complete cycle of a single leg's movement.}, archive = {J_ADVS}, author = {Qi Wen and Meiling Zhang and Jianwei Sun and Weijia Li and Jinkui Chu and Zhenyu Wang and Songyu Zhang and Luquan Ren}, doi = {10.1002/advs.202411351}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411351}, shortjournal = {Adv. Sci.}, title = {Legged robot with tensegrity feature bionic knee joint}, volume = {12}, year = {2025}, }
• (2025). Redox-induced stabilization of AMBRA1 by USP7 promotes intestinal oxidative stress and colitis through antagonizing DUB3-mediated NRF2 deubiquitination. ADVS, 12(12), 2411320. (www)

  @article{ , abstract = {Inflammatory bowel disease (IBD) is associated with oxidative stress and redox signaling disruption. It is recently reported that proautophagic autophagy/beclin-1 regulator 1 (AMBRA1) is a positive modulator of the NF-κB pathway that promotes intestinal inflammation. However, its effect on intestinal redox state and whether AMBRA1 is regulated by oxidative stress remain unknown. In this study, it is found that AMBRA1 functions as a pro-oxidative factor that increases oxidative stress in intestinal epithelial cells (IECs) in vitro and in vivo. Mechanistically, the N-terminal F1 domain is required for AMBRA1 to competitively interact with the N-terminal domain of NRF2, thereby antagonizing the interaction between deubiquitinating protein 3 (DUB3) and NRF2, suppressing DUB3-mediated NRF2 deubiquitination, and leading to NRF2 degradation. In response to H 2 O 2 stimulation, the interaction between AMBRA1 and ubiquitin-specific protease 7 (USP7) is enhanced, facilitating USP7 to deubiquitinate AMBRA1 at K83 and K86 and stabilize AMBRA1. Notably, the USP7 inhibitor, P5091, inhibits oxidative stress and colitis in vivo. Elevated AMBRA1 expression in inflamed colon tissues from ulcerative colitis patients is negatively correlated with decreased NRF2 protein levels. Overall, this study identifies AMBRA1 as a pro-oxidative factor in IECs and provides a redox-modulating therapeutic strategy for targeting USP7/AMBRA1 in IBD.}, archive = {J_ADVS}, author = {Weimin Xu and Zhebin Hua and Yaosheng Wang and Wenbo Tang and Wensong Ge and YingWei Chen and Zhongchuan Wang and Yubei Gu and Chen-Ying Liu and Peng Du}, doi = {10.1002/advs.202411320}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411320}, shortjournal = {Adv. Sci.}, title = {Redox-induced stabilization of AMBRA1 by USP7 promotes intestinal oxidative stress and colitis through antagonizing DUB3-mediated NRF2 deubiquitination}, volume = {12}, year = {2025}, }
• (2025). PLIN2 promotes lipid accumulation in ascites-associated macrophages and ovarian cancer progression by HIF1α/SPP1 signaling. ADVS, 12(12), 2411314. (www)

  @article{ , abstract = {A major characteristic of ovarian cancer (OC) is its unique route of metastasis via ascites. The immune microenvironment in ascites remains understudied, leaving the mechanism of ascites-mediated abdominal metastasis obscure. Here, a single-cell transcriptomic landscape of CD45 + immune cells across multiple anatomical sites is depicted, including primary tumors, metastatic lesions, and ascites, from patients diagnosed with high-grade serous ovarian carcinoma (HGSOC). A novel subset of perilipin 2 high (PLIN2 hi ) macrophages are identified that are enriched in ascites and positively correlated with OC progression, hence being designated as “ascites-associated macrophages (AAMs)”. AAMs are lipid-loaded with overexpression of the lipid droplet protein PLIN2. Overexpression or suppression of PLIN2 can enhance or inhibit tumor cell migration, invasion, and vascular permeability in vitro, which is also confirmed in vivo. Mechanistically, it is demonstrated that PLIN2 boosts HIF1α/SPP1 signaling in macrophages, thereby exerting pro-tumor functions. Finally, a PLIN2-targeting liposome is designed to efficiently suppress ascites production and tumor metastasis. Taken together, this work provides a comprehensive characterization of the cancer-promoting function and lipid-rich property of ascites-enriched PLIN2 hi macrophages, establishes a link between lipid metabolism and hypoxia within the context of the ascites microenvironment, and elucidates the pivotal role of ascites in trans-coelomic metastasis of OC.}, archive = {J_ADVS}, author = {Hui Luo and Xiaolu She and Yubo Zhang and Bingfan Xie and Shibo Zhang and Qianqian Li and Yangyang Zhou and Shuang Guo and Shushan Zhang and Yanhui Jiang and Yingying Dong and Jianzhong He and Lijie Wang and Qianqian Zhang and Yuan Zhuang and Panxia Deng and Feng Wang and Jihong Liu and Xin Chen and Huilong Nie and Huanhuan He}, doi = {10.1002/advs.202411314}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411314}, shortjournal = {Adv. Sci.}, title = {PLIN2 promotes lipid accumulation in ascites-associated macrophages and ovarian cancer progression by HIF1α/SPP1 signaling}, volume = {12}, year = {2025}, }
• (2025). Tailoring the anisotropic oxygen transport properties in bulk ceramic membranes based on a Ruddlesden–Popper oxide by applying magnetic fields. ADVS, 12(12), 2411251. (www)

  @article{ , abstract = {Textured Nd 2 NiO 4+ δ bulk ceramic membranes are fabricated via slip casting in a 0.9 T magnetic field generated by neodymium magnets. This process aligns the oxide grains with their easy-magnetization c -axis parallel to the applied magnetic field. Depending on the magnetic field's direction relative to the slip casting, grains orient either with their a , b -plane or c -axis parallel to the normal direction of the disk-shaped ceramic, thus aligning with the oxygen permeation direction. Without the magnetic field, a non-textured bulk membrane is formed. The microstructure and texture of the ceramic membranes are meticulously analyzed using advanced techniques, including X-ray diffraction, scanning and transmission electron microscopy, as well as related methods. Evaluation of the texturing effect on the oxygen permeation performance shows that the a , b -plane textured Nd 2 NiO 4+ δ bulk membrane achieves the highest oxygen permeation fluxes between 1023–1223 K. Additionally, it demonstrates impressive CO₂ stability, maintaining effective performance for at least 140 h due to preferential oxygen transport along the a , b -plane. These characteristics make Nd 2 NiO 4+ δ an auspicious material for industrial applications as an oxygen transport membrane, outperforming more susceptible perovskite-based materials. Magnetic alignment thus proves to be an effective method for achieving membrane texturing, enabling precise regulation of oxygen transport properties.}, archive = {J_ADVS}, author = {Giamper Escobar Cano and Motohide Matsuda and Zhijun Zhao and Frank Steinbach and Bernd Breidenstein and Hilke Petersen and Andreas Graff and Marc Widenmeyer and Anke Weidenkaff and Armin Feldhoff}, doi = {10.1002/advs.202411251}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411251}, shortjournal = {Adv. Sci.}, title = {Tailoring the anisotropic oxygen transport properties in bulk ceramic membranes based on a Ruddlesden–Popper oxide by applying magnetic fields}, volume = {12}, year = {2025}, }
• (2025). Tunable picoliter-scale dropicle formation using amphiphilic microparticles with patterned hydrophilic patches. ADVS, 12(12), 2411014. (www)

  @article{ , abstract = {Microparticle-templated droplets or dropicles have recently gained interest in the fields of diagnostic immunoassays, single-cell analysis, and digital molecular biology. Amphiphilic particles have been shown to spontaneously capture aqueous droplets within their cavities upon mixing with an immiscible oil phase, where each particle templates a single droplet. Here, an amphiphilic microparticle with four discrete hydrophilic patches embedded at the inner corners of a square-shaped hydrophobic outer ring of the particle (4C particle) is fabricated. Three dimensional computational fluid dynamics simulations predict droplet formation dynamics and differing equilibrium conditions depending on the patterning configuration. Experiments recapitulate equilibrium conditions, enabling tunable dropicle configurations with reproducible volumes down to ≈200 pL templated by the amphiphilic particles. The dropicle configurations depend predominantly on the size of the hydrophilic patches of the 4C particles. This validates that the modeling approach can inform the design of dropicles with varying volumes and numbers per particle, which can be harnessed in new amplified bioassays for greater sensitivity, dynamic range, and statistical confidence.}, archive = {J_ADVS}, author = {Xinpei Song and Shreya Udani and Mengxing Ouyang and Mehmet Akif Sahin and Dino Di Carlo and Ghulam Destgeer}, doi = {10.1002/advs.202411014}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411014}, shortjournal = {Adv. Sci.}, title = {Tunable picoliter-scale dropicle formation using amphiphilic microparticles with patterned hydrophilic patches}, volume = {12}, year = {2025}, }
• (2025). Aging-induced alternation in the gut microbiota impairs host antibacterial defense. ADVS, 12(12), 2411008. (www)

  @article{ , abstract = {Older individuals experience increased susceptibility and mortality to bacterial infections, but the underlying etiology remains unclear. Herein, it is shown that aging-associated reduction of commensal Parabacteroides goldsteinii ( P. goldsteinii ) in both aged mice and humans critically contributes to worse outcomes of bacterial infection. The colonization of live P. goldsteinii conferred protection against aging-associated bacterial infections. Metabolomic profiling reveals a protective compound, apigenin, generated by P. goldsteinii , antagonizes bacterial clearance defects in aged mice. AMP-binding protein ( ampB ) is identified as a key gene involved in apigenin synthesis in P. goldsteinii using homologous recombination in bacteria. Mechanistically, apigenin binds directly to the potential sites on Fgr (M341 and D404), preventing its inhibitory role on Vav1 phosphorylation, and therefore promoting the activation of Cdc42/Rac1, Arp2/3 expression and subsequent actin reorganization, which contributes to the enhanced phagocytosis of macrophages to bacteria. Collectively, the findings suggest that dysbiosis of the gut microbiota may impair host defense mechanisms and increase susceptibility to bacterial infections in older adults and highlight the microbiota-apigenin-Fgr axis as a possible route to ameliorate aging-associated antibacterial defects.}, archive = {J_ADVS}, author = {Peng Gu and Rongjuan Wei and Ruofan Liu and Qin Yang and Yuxuan He and Jianbin Guan and Wenhao He and Jiaxin Li and Yunfei Zhao and Li Xie and Jie He and Qingling Guo and Jiajia Hu and Jingna Bao and Wandang Wang and Jiayin Guo and Zhenhua Zeng and Zhongqing Chen and Yong Jiang and Zhanguo Liu and Peng Chen}, doi = {10.1002/advs.202411008}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2411008}, shortjournal = {Adv. Sci.}, title = {Aging-induced alternation in the gut microbiota impairs host antibacterial defense}, volume = {12}, year = {2025}, }
• (2025). NGR-modified CAF-derived exos targeting tumor vasculature to induce ferroptosis and overcome chemoresistance in osteosarcoma. ADVS, 12(12), 2410918. (www)

  @article{ , abstract = {Osteosarcoma (OS) chemoresistance presents a significant clinical challenge. This study aims to investigate the potential of using tumor vascular-targeting peptide NGR-modified cancer-associated fibroblasts (CAFs)-derived exosomes (exos) to deliver circ_0004872-encoded small peptides promoting autophagy-dependent ferroptosis to reverse chemoresistance in OS. Through combined single-cell transcriptome analysis and high-throughput sequencing, it identified circ_0004872 associated with chemoresistance. Subsequent experiments demonstrated that the small peptide encoded by this Circular RNA (circRNA) can effectively reverse chemoresistance by enhancing OS cell sensitivity to chemotherapy via the mechanism of promoting autophagy-dependent ferroptosis. Moreover, in vitro and in vivo results confirmed the efficient delivery of NGR-modified CAFs-derived exo-packaged circ_0004872-109aa to tumor cells, thereby improving targeted therapy efficacy. This study not only offers a novel strategy to overcome chemoresistance in OS but also highlights the potential application value of utilizing exos for drug delivery.}, archive = {J_ADVS}, author = {Jianxin Du and Xiangwei Meng and Minghao Yang and Guancheng Chen and Jigang Li and Zengjun Zhu and Xuanxuan Wu and Wei Hu and Maojin Tian and Tao Li and Shuai Ren and Peiqing Zhao}, doi = {10.1002/advs.202410918}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2410918}, shortjournal = {Adv. Sci.}, title = {NGR-modified CAF-derived exos targeting tumor vasculature to induce ferroptosis and overcome chemoresistance in osteosarcoma}, volume = {12}, year = {2025}, }
• (2025). Microglial cGAS deletion preserves intercellular communication and alleviates amyloid-β-induced pathogenesis of alzheimer's disease. ADVS, 12(12), 2410910. (www)

  @article{ , abstract = {Innate immune activation plays a crucial role in the pathogenesis of Alzheimer's disease (AD) and related dementias (ADRD). The cytosolic DNA sensing pathway, involving cGAMP synthase (cGAS) and Stimulator of Interferon Genes (STING), has emerged as a key mediator of neurodegenerative diseases. However, the precise mechanisms through which cGAS activation influences AD progression remain poorly understood. In this study, we observed significant up-regulation of cGAS-STING signaling pathway in AD. Notably, this increase is primarily attributed to microglia, rather than non-microglial cell types. Using an inducible, microglia-specific cGAS knockout mouse model in the 5xFAD background, we demonstrated that deleting microglial cGAS at the onset of amyloid-β (Aβ) pathology profoundly restricts plaque accumulation and protects mice from Aβ-induced cognitive impairment. Mechanistically, our study revealed cGAS promotes plaque-associated microglia accumulation and is essential for inflammasome activation. Moreover, we showed that restricting cGAS-mediated innate immunity is crucial for preserving inter-cellular communication in the brain and induces pleiotrophin, a neuroprotective factor. These findings offer novel insights into the specific roles of the innate immune system in AD employing a cell-type-specific approach. The conclusions provide a foundation for targeted interventions to modulate the microglial cGAS-STING signaling pathway, offering promising therapeutic strategy for AD treatment.}, archive = {J_ADVS}, author = {Sijia He and Xin Li and Namrata Mittra and Anindita Bhattacharjee and Hu Wang and Shujie Song and Shangang Zhao and Feng Liu and Xianlin Han}, doi = {10.1002/advs.202410910}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2410910}, shortjournal = {Adv. Sci.}, title = {Microglial cGAS deletion preserves intercellular communication and alleviates amyloid-β-induced pathogenesis of alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Small Singlet–Triplet gap terpolymer donor with a simple pt complex enables organic solar cells with low energy loss and over 19.2% efficiency. ADVS, 12(12), 2410154. (www)

  @article{ , abstract = {Suppressing the non-radiative loss in the organic solar cells (OSCs) through molecular design remains a significant challenge. Typically, triplet state of organic semiconductors is lower than the charge transfer (CT) state, contributing to substantial non-radiative loss via the triplet state. Herein, a set of terpolymers is prepared by introducing a simple Pt complex block into the PM6 polymer backbone. These metalated terpolymers exhibit high triplet energy ( E T1 ) and small singlet–triplet energy gap (∆ E ST ), facilitating fast intersystem crossing (ISC) process to generate triplet excitons. Consequently, the metalated terpolymers show enhanced exciton lifetime and diffusion length, and most importantly, effectively suppress the non-radiative recombination via terminal triplet loss channels. Moreover, the Pt complex modifies the molecular aggregation of the polymer, hence optimizing the morphology of the active blends. The PM6-Pt1:L8-BO devices achieve a champion power conversion efficiency (PCE) of 18.54% (certified as 18.32%), the highest reported for metalated terpolymers to date. The PCE is further increased to a record high 19.24% in the PM6-Pt1:PM6:L8-BO (0.8:0.2:1.2, wt/wt/wt) ternary devices. Overall, this work provides a feasible approach to designing terpolymers with high E T1 , thereby reducing non-radiative loss in the OSCs.}, archive = {J_ADVS}, author = {Dou Luo and Lifu Zhang and Lanqing Li and Tingting Dai and Erjun Zhou and Mao Quan and Hongyang Zhang and Aung Ko Ko Kyaw and Wai-Yeung Wong}, doi = {10.1002/advs.202410154}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2410154}, shortjournal = {Adv. Sci.}, title = {Small Singlet–Triplet gap terpolymer donor with a simple pt complex enables organic solar cells with low energy loss and over 19.2% efficiency}, volume = {12}, year = {2025}, }
• (2025). A novel protein NLRP12-119aa that prevents rhabdovirus replication by disrupting the RNP complex formation. ADVS, 12(12), 2409953. (www)

  @article{ , abstract = {The accurate assembly of the ribonucleoprotein (RNP) complex is fundamental for the replication and transcription of rhabdoviruses, which are known for their broad pathogenic impact. A novel 119-amino-acid protein, NLRP12-119aa is identified, encoded by the circular RNA circNLRP12, that effectively disrupts the formation of rhabdovirus RNP complexes through two distinct mechanisms and significantly reduces their replication. NLRP12-119aa exhibits a strong affinity for the conserved 18-nucleotide sequence at the start of the leader RNA of rhabdoviruses VSV, SCRV, and RABV, outcompeting their native N protein interactions, thereby disrupting the assembly of RNP complexes and inhibiting viral replication. NLRP12-119aa exerts anti-rhabdoviral effects by directly binding to the viral N protein, leading to its destabilization and accelerated degradation, and consequently hindering the formation of the viral RNP complex. To assess the therapeutic potential of circNLRP12 against rhabdovirus infections, a zebrafish model of VSV infection is established and noted a substantial reduction in viral load after-treatment with circNLRP12, as well as the recovery of spleen's to a normalized state from its previously enlarged and hemorrhagic state. Collectively, these findings elucidate a novel dual anti-RNP assembly strategy mediated by NLRP12-119aa, offering valuable insights for further exploration and clinical management of rhabdoviral infections.}, archive = {J_ADVS}, author = {Weiwei Zheng and Xiangxiang Zhu and Tongtong Zhu and Qiang Luo and Yan Zhao and Tianjun Xu}, doi = {10.1002/advs.202409953}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2409953}, shortjournal = {Adv. Sci.}, title = {A novel protein NLRP12-119aa that prevents rhabdovirus replication by disrupting the RNP complex formation}, volume = {12}, year = {2025}, }
• (2025). Understanding the stability of poorly covered pickering emulsions using on-chip microfluidics. ADVS, 12(12), 2409903. (www)

  @article{ , abstract = {Particle-stabilized emulsions, also known as Pickering emulsions, have shown promise in areas that require long-term stability with minimum use of surfactants. While most work has focused on densely covered Pickering emulsions, such emulsions are known to retain stability even when the interfaces are sparsely covered with particles. Here, the formation, dynamics, and stability of poorly covered model Pickering emulsions are studied in a controlled manner by utilizing a microfluidic platform. The formed Pickering emulsions remain highly stable, over at least 12 h, even with a surface area coverage below 3%. By directly visualizing the droplet interface at various stages, the exceptional stability is attributed to the highly spatially heterogeneous distribution of adsorbed particles which exclusively form particle bridges at the contact point between the droplets. Remarkably, these bridges are assembled in the form of crowns between the droplet interfaces, as visualized by confocal microscopy. The assembly behavior of the adsorbed particles in response to hydrodynamic forces and the formation of non-uniform particle distribution are discussed by analyzing the different forces present during emulsification, corroborated by numerical simulations. In conclusion, using a lab-on-a-chip approach, this work provides further understanding toward the fabrication of Pickering emulsions via preferential interfacial localization of particles.}, archive = {J_ADVS}, author = {Xuefeng Shen and Chang Chen and Berend van der Meer and Thomas E. Kodger and Uddalok Sen and Siddharth Deshpande and Jasper van der Gucht}, doi = {10.1002/advs.202409903}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2409903}, shortjournal = {Adv. Sci.}, title = {Understanding the stability of poorly covered pickering emulsions using on-chip microfluidics}, volume = {12}, year = {2025}, }
• (2025). Targeted delivery of c(RGDfk)-modified liposomes to bone marrow through in vivo hitchhiking neutrophils for multiple myeloma therapy. ADVS, 12(12), 2409895. (www)

  @article{ , abstract = {Multiple myeloma (MM) is a prevalent bone marrow disorder. The challenges in managing MM include selecting chemotherapy regimens that effectively modulate the myeloma microenvironment and delivering them to the bone marrow with high efficacy and minimal toxicity. Herein, a novel bone marrow targeting strategy using c(RGDfk) peptide-modified liposomes loaded with chemotherapeutics is developed, which can specifically recognize and hitchhike neutrophils following systemic administration, capitalizing on their natural aging process to facilitate precise drug delivery to the bone marrow, thus minimizing off-target effects. On the one hand, c(RGDfk)-functionalized liposomes containing carfilzomib (CRLPs) successfully transformed macrophages from M2 phenotype to M1 phenotype, enhancing immunotherapeutic responses. On the other hand, c(RGDfk)-functionalized liposomes encapsulating BMS-202 (BRLPs), a small molecule checkpoint inhibitor, interrupted the PD-1/PD-L1 axis and promoted the infiltration of cytotoxic T cells. The co-administration of CRLPs and BRLPs successfully delivered drugs to bone marrow, leading to significant modulation of the myeloma microenvironment, reduced tumor growth, and improved survival time of MM-bearing mouse models. These findings introduced an alternative approach to modulating the myeloma microenvironment and underscored the efficacy of hitchhiking neutrophils for bone marrow drug delivery. This strategy show advantages over traditional drug delivery methods in terms of improved efficacy and lowered toxicity.}, archive = {J_ADVS}, author = {Huiwen Liu and Bo Zhang and Hongrui Chen and Honglan Wang and Xifeng Qin and Chunyan Sun and Zhiqing Pang and Yu Hu}, doi = {10.1002/advs.202409895}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2409895}, shortjournal = {Adv. Sci.}, title = {Targeted delivery of c(RGDfk)-modified liposomes to bone marrow through in vivo hitchhiking neutrophils for multiple myeloma therapy}, volume = {12}, year = {2025}, }
• (2025). Chromosome missegregation triggers tumor cell pyroptosis and enhances anti-tumor immunotherapy in colorectal cancer. ADVS, 12(12), 2409769. (www)

  @article{ , abstract = {Immune checkpoint inhibitor (ICI) therapy is a promising anti-tumor therapeutic strategy; however, its efficacy in solid tumors is limited. Chromosome missegregation is common in various solid tumors; however, its role in tumor progression remains poorly understood, and its correlation with ICI is yet to be explored. Here, it is found that increased chromosome missegregation promotes tumor immune microenvironment, and eventually immunotherapeutic efficacy, by triggering pyroptosis. yin yang 2 (YY2) is identified as a mitotic checkpoint regulator, which promotes chromosome missegregation by upregulating BUB1B transcription. Increased chromosome missegregation promoted the formation of micronuclei and release of double-stranded DNA (dsDNA) into the cytosol, triggering an AIM2-mediated cytosolic dsDNA response. The subsequent pyroptosis strengthened the tumor immune microenvironment, thereby enhancing immunoinfiltration and cytotoxicity of CD8 + T cells, while preventing their exhaustion. Finally, through in vitro and in vivo experiments, it is demonstrated that combining YY2 overexpression-induced chromosome missegregation/cytosolic dsDNA response and PD-1 inhibitor significantly enhanced the efficacy of ICI immunotherapy in microsatellite instable and microsatellite stable colorectal cancer cells. Together, these findings provide new insights on the role of chromosome missegregation in triggering cytosolic dsDNA response-mediated pyroptosis and modulating the tumor immune microenvironment, suggesting a novel strategy for improving ICI therapeutic efficacy in colorectal cancer.}, archive = {J_ADVS}, author = {Wei Duan and Rendy Hosea and Lingxian Wang and Cao Ruan and Fuqiang Zhao and Jingyi Liu and Hezhao Zhao and Makoto Miyagishi and Shourong Wu and Vivi Kasim}, doi = {10.1002/advs.202409769}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2409769}, shortjournal = {Adv. Sci.}, title = {Chromosome missegregation triggers tumor cell pyroptosis and enhances anti-tumor immunotherapy in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). MSCs suppress macrophage necroptosis and foster liver regeneration by modulating SP1/SK1 axis in treating acute severe autoimmune hepatitis. ADVS, 12(12), 2408974. (www)

  @article{ , abstract = {Acute severe autoimmune hepatitis (AS-AIH) is characterized by rapid progression and poor prognosis, with a current lack of effective targeted treatments. Stem cell therapy has demonstrated significant therapeutic promise across various autoimmune diseases. However, the intricate pathogenesis of AS-AIH has hindered the widespread utilization of mesenchymal stem cells (MSCs) in this domain. Herein, it is demonstrated that necroptosis, as the primary mode of cell death in AIH, is crucial in causing AS-AIH. Inflammatory macrophages are the primary cell population involved in necroptosis. Inhibition of the specificity protein 1/sphingosine kinase 1/sphingosine-1-phosphate (SP1/SK1/S1P) axis is responsible for this phenomenon, leading to excessive activation of the intrahepatic immune system and aggravating liver damage. Furthermore, the S1P/S1PR2/YAP axis is the key pathway in initiating liver regeneration during AS-AIH. S1P synthesized by hepatocytes is the primary source, and this process is also regulated by the SP1/SK1 axis. MSCs promote S1P synthesis by macrophages through the delivery of SP1, which inhibits necroptosis and synergistically enhances liver regeneration. In addition, MSCs also promote S1P synthesis in hepatocytes through the same mechanism, further aiding liver regeneration. These findings unveil the core pathogenesis of AS-AIH and provide a theoretical foundation for using MSCs as a potential targeted therapeutic modality.}, archive = {J_ADVS}, author = {Ran An and Zhengyi Zhu and Yuyan Chen and Wenxian Guan and Jinglin Wang and Haozhen Ren}, doi = {10.1002/advs.202408974}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2408974}, shortjournal = {Adv. Sci.}, title = {MSCs suppress macrophage necroptosis and foster liver regeneration by modulating SP1/SK1 axis in treating acute severe autoimmune hepatitis}, volume = {12}, year = {2025}, }
• (2025). Lactylation of HDAC1 confers resistance to ferroptosis in colorectal cancer. ADVS, 12(12), 2408845. (www)

  @article{ , abstract = {Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti-ferroptosis therapy. Through drug screening, it is found that histone deacetylase inhibitor (HDACi) significantly sensitized CRC to ferroptosis. The combination of HDACi and ferroptosis inducers synergically suppresses CRC growth both in vivo and in vitro. Mechanically, HDACi reduces ferroptosis suppressor protein (FSP1) by promoting its mRNA degradation. Specifically, it is confirmed that HDACi specifically targets HDAC1 and promotes the H3K27ac modification of fat mass- and obesity-associated gene (FTO) and AlkB Homolog 5, RNA Demethylase (ALKBH5), which results in significant activation of FTO and ALKBH5. The activation of FTO and ALKBH5 reduces N6-methyladenosine (m 6 A) modification on FSP1 mRNA, leading to its degradation. Crucially, lactylation of HDAC1 K412 is essential for ferroptosis regulation. Both Vorinostat (SAHA) and Trichostatin A (TSA) notably diminish HDAC1 K412 lactylation in comparison to other HDAC1 inhibitors, exhibiting a consistent trend of increasing susceptibility to ferroptosis. In conclusion, the research reveals that HDACi decreases HDAC1 K412 lactylation to sensitize CRC to ferroptosis and that the combination of HDACi and ferroptosis inducers can be a promising therapeutic strategy for CRC.}, archive = {J_ADVS}, author = {Zhou Yang and Wei Su and Qinglin Zhang and Lili Niu and Baijie Feng and Yu Zhang and Feng Huang and Jiaxin He and Qinyao Zhou and Xin Zhou and Longjun Ma and Jingwan Zhou and Yuanrong Wang and Wenjing Xiong and Jun Xiang and Zhilin Hu and Qiang Zhan and Bing Yao}, doi = {10.1002/advs.202408845}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2408845}, shortjournal = {Adv. Sci.}, title = {Lactylation of HDAC1 confers resistance to ferroptosis in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Thermally triggered double emulsion-integrated hydrogel microparticles for multiplexed molecular diagnostics. ADVS, 12(12), 2408158. (www)

  @article{ , abstract = {During the COVID-19 pandemic, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) has been recognized as the most reliable diagnostic tool. However, there is a need to develop multiplexed assays capable of analyzing multiple genes simultaneously to expand its application. To address this, a multiplexed RT-qPCR using a double emulsion (DE)-based carrier and a polymer microparticle reactor, termed primer-incorporated network tailored with Taqman probe (TaqPIN) is developed. The DE securely stores nucleic acid reagents like primers and probes within the polymer network until heating releases them for the reaction. The TaqPIN RT-qPCR demonstrates an amplification efficiency of 93.8% and can detect as few as 20 copies/µL. By loading the multiple microparticles into a single reaction, a multiplexed assay with only one optical channel is enabled. In practice, a nine-plex assay is designed to distinguish between variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even subtle variations of a single nucleotide can be simultaneously detected. Testing on 75 nasopharyngeal swab samples yields 100% sensitivity and specificity for SARS-CoV-2 detection and 94% accuracy in variant discrimination.}, archive = {J_ADVS}, author = {Eui Ju Jeon and Seungwon Jung and Yoon-ha Jang and Seoyoung Lee and Song-Ee Choi and So Young Jeon and Lankyeong Yoon and Bong Kyun Kim and Tae Jong Kim and Kuenyoul Park and Seok Chung and Yong Shin and Sung-Han Kim and Heungsup Sung and Sang Kyung Kim}, doi = {10.1002/advs.202408158}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2408158}, shortjournal = {Adv. Sci.}, title = {Thermally triggered double emulsion-integrated hydrogel microparticles for multiplexed molecular diagnostics}, volume = {12}, year = {2025}, }
• (2025). Targeting mesothelin enhances personalized neoantigen vaccine induced antitumor immune response in orthotopic pancreatic cancer mouse models. ADVS, 12(12), 2407976. (www)

  @article{ , abstract = {The immunosuppressive microenvironment in pancreatic cancer, characterized by low tumor-specific T cells and excessive fibrosis, limits the effectiveness of immunotherapy. Here, three datasets and multi-immunofluorescence staining of tissue microarrays in pancreatic cancer indicate that mesothelin (MSLN) expression negatively correlates with cytotoxic T cells in tumor. Anti-MSLN antibody ( α MSLN) treatment of pancreatic cancer in vivo can significantly increase T cell infiltration. Meanwhile, the combination of α MSLN and neoantigen peptide vaccine identified from pancreatic cancer cell lines is demonstrated to be more effective in inducing neoantigen-specific T cell generation and infiltration at subcutaneous and orthotopic pancreatic cancer models for enhancing antitumor efficacy. Single-cell transcriptome analysis shows that the combined treatment significantly reduces the proportion of fibroblasts, improves the infiltration of IFN- γ + CD4 + and GZMK + CD8 + T cells, as well as reduces the interaction of antigen presentation-associated ligands and receptors between antigen-presenting Cancer-Associated Fibroblasts (apCAFs) and naive CD4 + T cells. The negative correlations between apCAFs and CD8 + T cells/IFN- γ + CD4 + T cells are further confirmed in human pancreatic cancer tissues. Overall, this study demonstrates that targeting MSLN can improve neoantigen vaccine induced immune efficacy by reducing apCAFs to interrupt the conversion of naive CD4 + T cells to Tregs, and therefore increase the infiltration of tumor-specific T cells.}, archive = {J_ADVS}, author = {Zhixiong Cai and Zhenli Li and Wenting Zhong and Fangzhou Lin and Xiuqing Dong and Honghao Ye and Yutong Guo and Geng Chen and Xiaoling Yu and Haijun Yu and Ruijing Tang and Xiaolong Liu}, doi = {10.1002/advs.202407976}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2407976}, shortjournal = {Adv. Sci.}, title = {Targeting mesothelin enhances personalized neoantigen vaccine induced antitumor immune response in orthotopic pancreatic cancer mouse models}, volume = {12}, year = {2025}, }
• (2025). Fast reverse design of 4D-printed voxelized composite structures using deep learning and evolutionary algorithm. ADVS, 12(12), 2407825. (www)

  @article{ , abstract = {Designing voxelized composite structures via 4D printing involves creating voxel units with distinct material properties that transform in response to stimuli; however, optimally distributing these properties to achieve specific target shapes remains a significant challenge. This study introduces an optimization method combining deep learning (DL) and an evolutionary algorithm, focusing on a solvent-responsive hydrogel as the target material. A sequence-enhanced parallel convolutional neural network is developed and generated a dataset through finite element simulations. This DL model enables high-precision prediction of hydrogel deformation. Furthermore, a progressive evolutionary algorithm (PEA) is proposed by integrating the DL model to construct a DL-PEA framework. This framework supports rapid reverse engineering of the desired shape, and the average design time for specified target shapes is reduced to ≈3.04 s. The present findings illustrate how 4D printing of optimized hydrogel designs can effectively transform in response to environmental stimuli. This work provides a new perspective on the application of hydrogels in 4D printing and presents an efficient tool for optimizing 4D-printed voxelized composite structures.}, archive = {J_ADVS}, author = {Mengtao Wang and Zaiyang Liu and Hidemitsu Furukawa and Zhuo Li and Yifei Ge and Yifan Xu and Zhe Qiu and Yang Tian and Zhongkui Wang and Ren Xu and Lin Meng}, doi = {10.1002/advs.202407825}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2407825}, shortjournal = {Adv. Sci.}, title = {Fast reverse design of 4D-printed voxelized composite structures using deep learning and evolutionary algorithm}, volume = {12}, year = {2025}, }
• (2025). CD47 knock-out using CRISPR-cas9 RNA lipid nanocarriers results in reduced mesenchymal glioblastoma growth in vivo. ADVS, 12(12), 2407262. (www)

  @article{ , abstract = {Immune checkpoint (ICP) blockade has shown limited effectiveness in glioblastoma (GBM), particularly in the mesenchymal subtype, where interactions between immune cells and glioblastoma cancer stem cells (GSCs) drive immunosuppression and therapy resistance. Tailoring ICPs specific to GSCs can enhance the antitumor immune response. This study proposes the use of lipid nanoparticles (LNPs) encapsulating CRISPR RNAs as an in vivo screening tool for ICPs in a syngeneic model of mesenchymal GSCs. Using PD-L1 and CD47 to validate the proof of concept, intratumoral administration of LNPs in orthotopic tumors achieved efficient editing of ICPs, leading to enhanced immune cell infiltration within the tumor microenvironment. Targeting CD47 reduced tumor growth, suggesting improved cancer cell sensitization to the immune system post-ICP editing. The study positions LNPs as a robust tool for in vivo validation of ICPs as therapeutic targets in clinically relevant GBM models. LNPs could serve as a screening tool in patient-derived xenografts to identify and optimize ICP combinations, potentially expediting ICP translation and enhancing personalized GBM immunotherapies.}, archive = {J_ADVS}, author = {Nadia Rouatbi and Adam A. Walters and Alaa Zam and Yau Mun Lim and Alessia Marrocu and Revadee Liam-Or and Joanne E. Anstee and James N. Arnold and Julie Tzu-Wen Wang and Steven M. Pollard and Khuloud T. Al-Jamal}, doi = {10.1002/advs.202407262}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2407262}, shortjournal = {Adv. Sci.}, title = {CD47 knock-out using CRISPR-cas9 RNA lipid nanocarriers results in reduced mesenchymal glioblastoma growth in vivo}, volume = {12}, year = {2025}, }
• (2025). The diminution of R-loops generated by LncRNA DSP-AS1 inhibits DSP gene transcription to impede the re-epithelialization during diabetic wound healing. ADVS, 12(12), 2406021. (www)

  @article{ , abstract = {Re-epithelialization constitutes a critical stage in the intricate process of wound healing, yet its mechanisms in the context of diabetic wounds remain elusive. In this study, the role of the mesenchymal-epithelial transition (MET) vis-à-vis the epithelial-mesenchymal transition (EMT) of keratinocytes in diabetic wound re-epithelialization is investigated. The findings reveal an impediment in the MET process, rather than EMT, which significantly compromised re-epithelialization in diabetic wounds. Furthermore, Desmoplakin ( DSP ) gene expression, encoding a key desmosome protein, is down-regulated in diabetic rats. This down-regulation coincided with aberrant hypo-demethylation of the DSP promoter. The inhibition of DSP expression is linked to reduced occupancy of Ten-eleven translocation 3 (TET3) at the DSP promoter, consequently suppressing TET3-dependent DNA demethylation. Additionally, a novel lncRNA termed DSP-AS1is identified, which is antisense to DSP . Notably, DSP-AS1 expression is down-regulated in diabetic skin wounds, and it interacted with TET3, a DNA demethylase. Notably, DSP-AS1 is found to form R-loops, triple-stranded DNA:RNA hybrids, at the DSP promoter, facilitating TET3 localization to the DSP promoter. Collectively, the findings suggest that reduced R-loop formation by DSP-AS1 impairs DSP gene transcription by repressing TET3-mediated DNA demethylation. This disruption of the orchestrated re-epithelialization process contributes to refractory diabetic wound healing.}, archive = {J_ADVS}, author = {Chen Yang and Hong Lian and Hengli Luo and Chenlin Song and Jianghong Lin and Zhuoxian Liang and Yulin Yang and Xiaosi Hong and Shaohua Li and Yanbo Chen and Liangyan Wu and Li Yan and Sifan Chen and Meng Ren}, doi = {10.1002/advs.202406021}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2406021}, shortjournal = {Adv. Sci.}, title = {The diminution of R-loops generated by LncRNA DSP-AS1 inhibits DSP gene transcription to impede the re-epithelialization during diabetic wound healing}, volume = {12}, year = {2025}, }
• (2025). Enabling targeted drug delivery for treatment of ulcerative colitis with mucosal-adhesive photoreactive hydrogel. ADVS, 12(12), 2404836. (www)

  @article{ , abstract = {Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non-specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompatible gelation that can efficiently cover irregular tissue surfaces provides an effective approach for targeted drug delivery at the gastrointestinal (GI) tract. An ideal integration of synthetic material with intestinal epithelium entails an integrated and preferable chemically bonded interface between the hydrogel and mucosal surface. In this study, a photo-triggered coupling reaction is leveraged as the crosslinking platform to develop a mucosal-adhesive hydrogel, which is compatible with endoscope-directed drug delivery for UC treatment. The results demonstrated superior spatiotemporal specificity and drug pharmacokinetics with this delivery system in vivo. Delivery of different drugs with the hydrogel leads to greatly enhanced therapeutic efficacy and significantly reduced systemic drug exposure with rat colitis models. The study presents a strategy for targeted and persistent drug delivery for UC treatment.}, archive = {J_ADVS}, author = {Wen Wu and Jian Zhang and Xiao Qu and Ting Chen and Jinming Li and Yongzhi Yang and Lifeng Chen and Alex Hoover and Fanying Guo and Cheng Kong and Bingkun Bao and Qiuning Lin and Mengxin Zhou and Linyong Zhu and Xiaoyang Wu and Yanlei Ma}, doi = {10.1002/advs.202404836}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2404836}, shortjournal = {Adv. Sci.}, title = {Enabling targeted drug delivery for treatment of ulcerative colitis with mucosal-adhesive photoreactive hydrogel}, volume = {12}, year = {2025}, }
• (2025). Deep learning-based ion channel kinetics analysis for automated patch clamp recording. ADVS, 12(12), 2404166. (www)

  @article{ , abstract = {The patch clamp technique is a fundamental tool for investigating ion channel dynamics and electrophysiological properties. This study proposes the first artificial intelligence framework for characterizing multiple ion channel kinetics of whole-cell recordings. The framework integrates machine learning for anomaly detection and deep learning for multi-class classification. The anomaly detection excludes recordings that are incompatible with ion channel behavior. The multi-class classification combined a 1D convolutional neural network, bidirectional long short-term memory, and an attention mechanism to capture the spatiotemporal patterns of the recordings. The framework achieves an accuracy of 97.58% in classifying 124 test datasets into six categories based on ion channel kinetics. The utility of the novel framework is demonstrated in two applications: Alzheimer's disease drug screening and nanomatrix-induced neuronal differentiation. In drug screening, the framework illustrates the inhibitory effects of memantine on endogenous channels, and antagonistic interactions among potassium, magnesium, and calcium ion channels. For nanomatrix-induced differentiation, the classifier indicates the effects of differentiation conditions on sodium and potassium channels associated with action potentials, validating the functional properties of differentiated neurons for Parkinson's disease treatment. The proposed framework is promising for enhancing the efficiency and accuracy of ion channel kinetics analysis in electrophysiological research.}, archive = {J_ADVS}, author = {Shengjie Yang and Jiaqi Xue and Ziqi Li and Shiqing Zhang and Zhang Zhang and Zhifeng Huang and Ken Kin Lam Yung and King Wai Chiu Lai}, doi = {10.1002/advs.202404166}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2404166}, shortjournal = {Adv. Sci.}, title = {Deep learning-based ion channel kinetics analysis for automated patch clamp recording}, volume = {12}, year = {2025}, }
• (2025). Excessive MYC orchestrates macrophages induced chromatin remodeling to sustain micropapillary-patterned malignancy in lung adenocarcinoma. ADVS, 12(12), 2403851. (www)

  @article{ , abstract = {Current understanding of micropapillary (MP)-subtype lung adenocarcinoma (LUAD) remains confined to biological activities and genomic landscapes. Unraveling the major regulatory programs underlying MP patterned malignancy offers opportunities to identify more feasible therapeutic targets for patients with MP LUAD. This study shows that patients with MP subtype LUAD have aberrant activation of the MYC pathway compared to patients with other subtypes. In vitro and xenograft mouse model studies reveal that MP pattern in malignancy cannot be solely due to aberrant MYC expression but requires the involvement of M2-like macrophages. Excessively expressed MYC leads to the accumulation of M2-like macrophages from the bone marrow, which secretes TGFβ, to induce the expression of FOSL2 in tumor cells, thereby remodeling chromatin accessibility at promoter regions of MP-pattern genes to promote the MYC-mediated de novo transcriptional regulation of these genes. Additionally, the MP-pattern in malignancy can be effectively alleviated by disrupting the TGFβ-FOSL2 axis. These findings reveal new functions for the M2-like macrophage-TGFβ-FOSL2 axis in MYC-overexpressing MP-subtype LUAD, identifying targetable vulnerabilities in this pathway.}, archive = {J_ADVS}, author = {Xuming Song and Zehao Pan and Yi Zhang and Wenmin Yang and Te Zhang and Hui Wang and Yuzhong Chen and Xinnian Yu and Hanlin Ding and Rutao Li and Pengfei Ge and Lin Xu and Gaochao Dong and Feng Jiang}, doi = {10.1002/advs.202403851}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2403851}, shortjournal = {Adv. Sci.}, title = {Excessive MYC orchestrates macrophages induced chromatin remodeling to sustain micropapillary-patterned malignancy in lung adenocarcinoma}, volume = {12}, year = {2025}, }
• (2025). Loss of MNX1 sensitizes tumors to cytotoxic t cells by degradation of PD-l1 mRNA. ADVS, 12(12), 2403077. (www)

  @article{ , abstract = {Immune checkpoint blockade (ICB) therapy, targeting programmed cell death ligand-1 (PD-L1)/programmed cell death protein 1 (PD-1) axis and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), has exhibited amazing clinical outcomes in various types of cancers. However, only a small portion of patients benefit from ICB therapy, indicating that the mechanism underlying immune checkpoint is still unclear. Here, it is reported that motor neuron and pancreas homeobox 1 (MNX1), a homeobox domain-containing transcription factor, contributes to the tumor immune escape. MNX1 increases PD-L1 expression in cancer cells by stabilizing PD-L1 mRNA rather than activating transcription. Mechanistically, MNX1 exists in the cytoplasm of cancer cells and interacts with Y-box binding protein 1 (YBX1), a multifunctional DNA/RNA-binding protein, to enhance the binding of YBX1 to PD-L1 mRNA. MNX1 ablation activates cytotoxic T cell-mediated anti-tumor immunity and sensitizes CTLA-4 blockade therapy. Moreover, MNX1 also facilitates tumor progression in an immune-independent manner in cancer cells. In addition, MNX1 is upregulated by its adjacent long non-coding RNA MNX1-AS1 via HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2). Together, these results reveal MNX1 as a novel immune checkpoint regulator with promising therapeutic potential.}, archive = {J_ADVS}, author = {Zhengzheng Li and Lei Chen and Ge Zhang and Shuang Wang and Enhang Xu and Jinglei Teng and Jiancheng Xu and Fang Peng and Qingjie Min and Zhuoya Wang and Shujuan Shao and Lianmei Zhao and Baoen Shan and Yang Wang and Qimin Zhan and Xuefeng Liu}, doi = {10.1002/advs.202403077}, journal = {Advanced Science}, month = {3}, number = {12}, pages = {2403077}, shortjournal = {Adv. Sci.}, title = {Loss of MNX1 sensitizes tumors to cytotoxic t cells by degradation of PD-l1 mRNA}, volume = {12}, year = {2025}, }
• (2025). Ammonia synthesis over an iron catalyst with an inverse structure (Adv. sci. 11/2025). ADVS, 12(11), 2570076. (www)

  @article{ , archive = {J_ADVS}, author = {Masashi Hattori and Kento Miyashita and Yuki Nagasawa and Ryo Suzuki and Michikazu Hara}, doi = {10.1002/advs.202570076}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2570076}, shortjournal = {Adv. Sci.}, title = {Ammonia synthesis over an iron catalyst with an inverse structure (Adv. sci. 11/2025)}, volume = {12}, year = {2025}, }
• (2025). 3D printed mesh geometry modulates immune response and interface biology in mouse and sheep model: Implications for pelvic floor surgery (Adv. sci. 11/2025). ADVS, 12(11), 2570075. (www)

  @article{ , archive = {J_ADVS}, author = {Kallyanashis Paul and Saeedeh Darzi and Cathal D. O'Connell and David M. Z. B. Hennes and Anna Rosamilia and Caroline E. Gargett and Jerome A Werkmeister and Shayanti Mukherjee}, doi = {10.1002/advs.202570075}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2570075}, shortjournal = {Adv. Sci.}, title = {3D printed mesh geometry modulates immune response and interface biology in mouse and sheep model: Implications for pelvic floor surgery (Adv. sci. 11/2025)}, volume = {12}, year = {2025}, }
• (2025). Transfusion-related acute lung injury: From mechanistic insights to therapeutic strategies (Adv. sci. 11/2025). ADVS, 12(11), 2570074. (www)

  @article{ , archive = {J_ADVS}, author = {Xiaobin Fang and Chunheng Mo and Ling Zheng and Fei Gao and Fu-Shan Xue and Xiaochun Zheng}, doi = {10.1002/advs.202570074}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2570074}, shortjournal = {Adv. Sci.}, title = {Transfusion-related acute lung injury: From mechanistic insights to therapeutic strategies (Adv. sci. 11/2025)}, volume = {12}, year = {2025}, }
• (2025). Gaudichaudione h enhances the sensitivity of hepatocellular carcinoma cells to disulfidptosis via regulating NRF2-SLC7A11 signaling pathway (Adv. sci. 11/2025). ADVS, 12(11), 2570072. (www)

  @article{ , archive = {J_ADVS}, author = {Mengjiao Shi and Xinyan Li and Ying Guo and Yinggang Zhang and Jiayi Xu and Liangwen Yan and Rongrong Liu and Hong Wang and Shenkang Tang and Yaping Zhao and Zongfang Li and Yetong Feng and Dongmei Ren and Pengfei Liu}, doi = {10.1002/advs.202570072}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2570072}, shortjournal = {Adv. Sci.}, title = {Gaudichaudione h enhances the sensitivity of hepatocellular carcinoma cells to disulfidptosis via regulating NRF2-SLC7A11 signaling pathway (Adv. sci. 11/2025)}, volume = {12}, year = {2025}, }
• (2025). Scale-up of human amniotic epithelial cells through regulation of epithelial-mesenchymal plasticity under defined conditions (Adv. sci. 11/2025). ADVS, 12(11), 2570071. (www)

  @article{ , archive = {J_ADVS}, author = {Wangping Hao and Yi Luo and Jia Tian and Yuefeng Lu and Yangyang Cui and Ying Zhang and Xiao Jin and Hongjuan Ye and Mengqi Lu and Jinjia Song and Weiqing Zhou and Wencheng Zhang and Zhiying He}, doi = {10.1002/advs.202570071}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2570071}, shortjournal = {Adv. Sci.}, title = {Scale-up of human amniotic epithelial cells through regulation of epithelial-mesenchymal plasticity under defined conditions (Adv. sci. 11/2025)}, volume = {12}, year = {2025}, }
• (2025). A fuel cell power supply system equipped with artificial gill membranes for underwater applications (Adv. sci. 11/2025). ADVS, 12(11), 2570070. (www)

  @article{ , archive = {J_ADVS}, author = {Lucas Merckelbach and Prokopios Georgopanos}, doi = {10.1002/advs.202570070}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2570070}, shortjournal = {Adv. Sci.}, title = {A fuel cell power supply system equipped with artificial gill membranes for underwater applications (Adv. sci. 11/2025)}, volume = {12}, year = {2025}, }
• (2025). Development of a self-deploying extra-aortic compression device for medium-term hemodynamic stabilization: A feasibility study (Adv. sci. 11/2025). ADVS, 12(11), 2570069. (www)

  @article{ , archive = {J_ADVS}, author = {Adrienne Ji and James Davies and Phuoc Thien Phan and Chi Cong Nguyen and Bibhu Sharma and Kefan Zhu and Emanuele Nicotra and Jingjing Wan and Hoang-Phuong Phan and Christopher Hayward and Nigel H. Lovell and Thanh Nho Do}, doi = {10.1002/advs.202570069}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2570069}, shortjournal = {Adv. Sci.}, title = {Development of a self-deploying extra-aortic compression device for medium-term hemodynamic stabilization: A feasibility study (Adv. sci. 11/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “A flexible hybrid generator for efficient dual energy conversion from raindrops to electricity”. ADVS, 12(11), 2502344. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202502344}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2502344}, shortjournal = {Adv. Sci.}, title = {Correction to “A flexible hybrid generator for efficient dual energy conversion from raindrops to electricity”}, volume = {12}, year = {2025}, }
• (2025). Hinged carboxylate in the artificial distal pocket of an iron porphyrin enhances CO2 electroreduction at low overpotential. ADVS, 12(11), 2500482. (www)

  @article{ , abstract = {To efficiently capture, activate, and transform small molecules, metalloenzymes have evolved to integrate a well-organized pocket around the active metal center. Within this cavity, second coordination sphere functionalities are precisely positioned to optimize the rate, selectivity, and energy cost of catalytic reactions. Inspired by this strategy, an artificial distal pocket defined by a preorganized 3D strap is introduced on an iron-porphyrin catalyst ( sc-Fe ) for the CO 2 -to-CO electrocatalytic reduction. Combined electrochemical, kinetic, and computational studies demonstrate that the adequate positioning of a carboxylate/carboxylic group acting in synergy with a trapped water molecule within this distal pocket remarkably enhances the reaction turnover frequency (TOF) by four orders of magnitude compared to the perfluorinated iron-tetraphenylporphyrin catalyst ( F 20 Fe ) operating at a similar low overpotential. A proton-coupled electron transfer (PCET) is found to be the key process responsible for the unexpected protonation of the coordinating carboxylate, which, upon CO 2 insertion, shifts from the first to the second coordination sphere to play a possible secondary role as a proton relay.}, archive = {J_ADVS}, author = {Adrien Smith and Philipp Gotico and Régis Guillot and Stéphane Le Gac and Winfried Leibl and Ally Aukauloo and Bernard Boitrel and Marie Sircoglou and Zakaria Halime}, doi = {10.1002/advs.202500482}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2500482}, shortjournal = {Adv. Sci.}, title = {Hinged carboxylate in the artificial distal pocket of an iron porphyrin enhances CO2 electroreduction at low overpotential}, volume = {12}, year = {2025}, }
• (2025). Biomolecular microneedle initiates Fe3O4/MXene heterojunction-mediated nanozyme-like reactions and bacterial ferroptosis to repair diabetic wounds. ADVS, 12(11), 2417314. (www)

  @article{ , abstract = {Reactive oxygen species (ROS) play a dual role in wound healing. They act as crucial signaling molecules and antimicrobial agents when present at moderate levels. However, excessive levels of ROS can hinder the healing process for individuals with diabetes. As a result, targeting ROS levels to maintain redox balance has become a promising strategy for improving wound recovery. Currently, no biomaterials have been reported to simultaneously up-regulate and down-regulate ROS to achieve broad-spectrum antibacterial and antioxidant properties. Inspired by the site-dependent effect of nanomaterials, a micron-sized ferroferric oxide (Fe 3 O 4 )/MXene (FM) heterojunction is synthesized using a hydrothermal method. The FM heterojunction could scavenge extracellular ROS by activating catalase (CAT)-like and superoxide dismutase (SOD)-like nanozyme activities. Meanwhile, FM heterojunction could release ferric ions and ferrous ions by defect engineering to induce bacterial ferroptosis, up-regulating intercellular ROS, and lipid peroxidation. For applications in vivo, FM heterojunction is incorporated into the tips of gelatin methacryloyl (GelMA)-based microneedle (termed as GFM microneedle) using a two-step casting technique. The results showed that GFM microneedle combined with photothermal therapy could improve S. aureus -infected skin regeneration in diabetic rats. The effectiveness and safety of GFM microneedle are not less favorable than that of a commercial wound dressing. This study provides a proof-of-concept for heterojunction-mediated regenerative medicine via a site-dependent ROS-targeting strategy.}, archive = {J_ADVS}, author = {Wenjie You and Zichao Cai and Feng Xiao and Jiaxin Zhao and Guanyi Wang and Wang Wang and Zesheng Chen and Weikang Hu and Yun Chen and Zijian Wang}, doi = {10.1002/advs.202417314}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2417314}, shortjournal = {Adv. Sci.}, title = {Biomolecular microneedle initiates Fe3O4/MXene heterojunction-mediated nanozyme-like reactions and bacterial ferroptosis to repair diabetic wounds}, volume = {12}, year = {2025}, }
• (2025). Unraveling redox mediator-assisted chemical relithiation mechanism for direct recycling of spent ni-rich layered cathode materials. ADVS, 12(11), 2417094. (www)

  @article{ , abstract = {The increasing demand for Li-ion batteries across various energy storage applications underscores the urgent need for environmentally friendly and efficient direct recycling strategies to address the issue of substantial cathode waste. Diverse reducing agents for Li supplements, such as quinone molecules, have been considered to homogenize the Li distribution in the cathode materials obtained after cycling; however, the detailed reaction mechanism is still unknown. Herein, the ideal electrochemical potential factor and reaction mechanism of the redox mediator 3,5-di-tert-butyl-o-benzoquinone (DTBQ) for the chemical relithiation of high-Ni-layered cathodes are elucidated. Here, 100% efficiency of DTBQ-assisted chemical relithiation is achieved by adjusting the direct immersion time of Li-deficient cathode electrodes. The reversible reaction features of the physical and chemical structures of both the regenerated cathodes and the DTBQ molecules are investigated using advanced characterization and density functional theory calculations. These findings emphasize the potential of redox-mediator-assisted chemical relithiation for realizing direct recycling processes and offer a facile and sustainable solution for battery recycling.}, archive = {J_ADVS}, author = {Suji Kim and Ukseon Shin and Hyun Ju Yoon and Soo-Ah Yoon and Jinju Song and Jiyoung Ma and Jung-Je Woo and Kyung-Wan Nam and Dong-Hwa Seo and Won-Hee Ryu}, doi = {10.1002/advs.202417094}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2417094}, shortjournal = {Adv. Sci.}, title = {Unraveling redox mediator-assisted chemical relithiation mechanism for direct recycling of spent ni-rich layered cathode materials}, volume = {12}, year = {2025}, }
• (2025). High-coordination and nb-bridging of bimetallic amorphous p6-nb-W-p5 clusters in carbon nanospheres for high-performance sodium-ion hybrid capacitors. ADVS, 12(11), 2416942. (www)

  @article{ , abstract = {Amorphous clusters are gaining prominence as prospective hosts for sodium-ion hybrid capacitors (SIHCs), but their efficacy is still affected by atomic coordination. Optimization of ion storage and charge transport can be achieved through high coordination and bimetallic configurations. Herein, high-coordination amorphous P 6 -Nb-W-P 5 (Nb/W-P) clusters are skillfully tailored by bridging Nb into the second shell of W in the W-P 5 configuration, nested in situ in conductive and stable N, P co-doped carbon nanospheres (Nb/W-P@NPC). Such clusters with high atom utilization can offer profuse Na + storage sites due to their high coordination. As an electron donor, Nb-bridging can subtly modify the electronic structure of clusters, and broaden the hybridization of d-p orbitals, thus improving charge transfer efficiency and fostering diversified active sites. Compared with the low-coordinated W-P L @NPC and the high-coordinated W-P@NPC, the reversible capacity of Nb/W-P@NPC upgrades to 556.3 mAh g −1 at 0.1 A g −1 , alongside exceptional cycling stability at high rates. When integrated into SIHCs, the high energy density and high-power output (223.6 and 9800 W kg −1 ) are achieved. By systematically exploring the effect of high coordination and bimetallic design on the storage efficacies of amorphous clusters, this study has greatly advanced the development of SIHC technologies.}, archive = {J_ADVS}, author = {Shuxiao Hu and Baoquan Liu and Fanyan Zeng and Yang Pan and Dui Ma and Meilan Xie and Shenglian Luo}, doi = {10.1002/advs.202416942}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2416942}, shortjournal = {Adv. Sci.}, title = {High-coordination and nb-bridging of bimetallic amorphous p6-nb-W-p5 clusters in carbon nanospheres for high-performance sodium-ion hybrid capacitors}, volume = {12}, year = {2025}, }
• (2025). Characterization of the micro-morphology and compositional distribution of chang'e-5 lunar soil mineral surfaces using TOF-SIMS. ADVS, 12(11), 2416639. (www)

  @article{ , abstract = {The lunar soil samples returned by China's Chang'e-5 (CE-5) contain valuable information on geological evolutions on the Moon. Herein, by employing high-resolution time-of-flight secondary ion mass spectrometry (TOF-SIMS), five rock chip samples from the CE-5 lunar soil are characterized in-depth, which reveal micro-morphological and compositional features. From the elemental/molecular ion distribution images, minerals such as pyroxene, ilmenite, feldspar, K-rich glass, silica, and silicate minerals are identified, along with their occurrence states and distribution results. More importantly, uncommon vesicle-like patterns are probed via TOF-SIMS, which may not be captured by conventional electron microscopy. The possible origins of vesicles are also proposed. Hopefully, these discoveries will provide essential guidance for future investigations on the Moon and accelerate the application of TOF-SIMS in space exploration.}, archive = {J_ADVS}, author = {Tinglu Song and Jie Liu and Chunlin Zhang and Xinyu Yang and Taiyang Chen and Shunzi Jiang and Fan Xu and Ning Li and Menghua Zhu and Shaolin Li and Meishuai Zou}, doi = {10.1002/advs.202416639}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2416639}, shortjournal = {Adv. Sci.}, title = {Characterization of the micro-morphology and compositional distribution of chang'e-5 lunar soil mineral surfaces using TOF-SIMS}, volume = {12}, year = {2025}, }
• (2025). Global protein interactome mapping in rice using barcode-indexed PCR coupled with HiFi long-read sequencing. ADVS, 12(11), 2416243. (www)

  @article{ , abstract = {Establishing the protein–protein interaction network sheds light on functional genomics studies by providing insights from known counterparts. However, the rice interactome has barely been studied due to the lack of massive, reliable, and cost-effective methodologies. Here, the development of a barcode-indexed PCR coupled with HiFi long-read sequencing pipeline (BIP-seq) is reported for high throughput Protein Protein Interaction (PPI)identification. BIP-seq is essentially built on the integration of library versus library Y2H mating strategy to facilitate the efficient acquisition of random PPI colonies, semi-mechanized dual barcode-indexed yeast colony PCR for the large-scale indexed amplification of bait and prey cDNAs, and massive pac-bio sequencing of PCR amplicon pools. It is demonstrated that BIP-seq could map over 15 000 high-confidence (≈62.5% could be verified by Bimolecular fluorescence Complementation (BiFC)) rice PPIs within 2 months, outperforming the other reported methods. In addition, the obtained 23 032 rice PPIs, including 22,665 newly identified PPIs, greatly expanded the current rice PPI dataset, provided a comprehensive overview of the rice PPIs networks, and could be a valuable asset in facilitating functional genomics research in rice.}, archive = {J_ADVS}, author = {Xixi Liu and Dandan Xia and Jinjin Luo and Mengyuan Li and Lijuan Chen and Yiting Chen and Jie Huang and Yanan Li and Huayu Xu and Yang Yuan and Yu Cheng and Zhiyong Li and Guanghao Li and Shiyi Wang and Xinyong Liu and Wanning Liu and Fengyong Zhang and Zhichao Liu and Xiaohong Tong and Yuxuan Hou and Yifeng Wang and Jiezheng Ying and Abdullaev Mirtemir Baxodir ugli and Mukhammadjon Arabboevich Ergashev and Sanqiang Zhang and Wenya Yuan and Dawei Xue and Jianwei Zhang and Jian Zhang}, doi = {10.1002/advs.202416243}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2416243}, shortjournal = {Adv. Sci.}, title = {Global protein interactome mapping in rice using barcode-indexed PCR coupled with HiFi long-read sequencing}, volume = {12}, year = {2025}, }
• (2025). Melamine-copolymerization strategy engineered fluorinated polyimides for membrane-based sour natural gas separation. ADVS, 12(11), 2416109. (www)

  @article{ , abstract = {Membrane-based gas separation provides an energy-efficient approach for the simultaneous CO 2 and H 2 S removal from sour natural gas. The fluorinated polyimide (PI) membranes exhibited a promising balance between permeability and permselectivity for sour natural gas separation. To further improve the separation efficiency of fluorinated PI membranes, a melamine-copolymerization synthetic approach is devised that aims to incorporate melamine motifs with high sour gas affinity into the structure of the PI membranes. The fluorinated copolyimide membranes that are structurally engineered exhibited excellent solution-processability and enhanced sweet-mixed gas selectivity compared to their original PI membranes. Additionally, under a five-component sour mixed-gas feed, these melamine-copolymerized fluorinated PI membranes provided superior combined H 2 S and CO 2 removal efficiency in comparison to conventional glassy polymer membranes. The melamine-copolymerization strategy provides an easily operable and generally effective approach to developing performance-enhancing PI membranes for sour natural gas separation.}, archive = {J_ADVS}, author = {Yi Ren and Patrick T. Wright and Zhongyun Liu and Shijie Yang and Lu Lu and John Yang and Xuezhen Wang and Sheng Guo}, doi = {10.1002/advs.202416109}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2416109}, shortjournal = {Adv. Sci.}, title = {Melamine-copolymerization strategy engineered fluorinated polyimides for membrane-based sour natural gas separation}, volume = {12}, year = {2025}, }
• (2025). Exploration of multidimensional structural optimization and regulation mechanisms: Catalysts and reaction environments in electrochemical ammonia synthesis. ADVS, 12(11), 2416053. (www)

  @article{ , abstract = {Ammonia (NH 3 ) is esteemed for its attributes as a carbon-neutral fuel and hydrogen storage material, due to its high energy density, abundant hydrogen content, and notably higher liquefaction temperature in comparison to hydrogen gas. The primary method for the synthetic generation of NH 3 is the Haber–Bosch process, involving rigorous conditions and resulting in significant global energy consumption and carbon dioxide emissions. To tackle energy and environmental challenges, the exploration of innovative green and sustainable technologies for NH 3 synthesis is imperative. Rapid advances in electrochemical technology have created fresh prospects for researchers in the realm of environmentally friendly NH 3 synthesis. Nevertheless, the intricate intermediate products and sluggish kinetics in the reactions impede the progress of green electrochemical NH 3 synthesis (EAS) technologies. To improve the activity and selectivity of the EAS, which encompasses the electrocatalytic reduction of nitrogen gas, nitrate, and nitric oxide, numerous electrocatalysts and design strategies have been meticulously investigated. Here, this review primarily delves into recent progress and obstacles in EAS pathways, examining methods to boost the yield rate and current efficiency of NH 3 synthesis via multidimensional structural optimization, while also exploring the challenges and outlook for EAS.}, archive = {J_ADVS}, author = {Kaibin Chu and Bo Weng and Zhaorui Lu and Yang Ding and Wei Zhang and Rui Tan and Yu-Ming Zheng and Ning Han}, doi = {10.1002/advs.202416053}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2416053}, shortjournal = {Adv. Sci.}, title = {Exploration of multidimensional structural optimization and regulation mechanisms: Catalysts and reaction environments in electrochemical ammonia synthesis}, volume = {12}, year = {2025}, }
• (2025). Multifunctional fluorescent probe for simultaneous detection of ATP, cys, hcy, and GSH: Advancing insights into epilepsy and liver injury. ADVS, 12(11), 2415882. (www)

  @article{ , abstract = {Adenosine triphosphate (ATP) is a critical intracellular energy currency that plays a key role in various cellular processes and is closely associated with numerous diseases. Similarly, biothiols such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy) are integral to many physiological and pathological processes due to their strong redox properties. Simultaneous discrimination and detection of ATP and biothiols offer valuable insights into the pathogenesis of conditions such as epilepsy and liver injury. This study introduces the first fluorescent probe, BCR , designed for multifunctional detection of ATP, GSH, Hcy, and Cys. With outstanding optical properties, excellent biocompatibility, high selectivity, and superior sensitivity, probe BCR enables effective imaging of ATP and biothiol dynamics in vivo. Moreover, probe BCR successfully visualizes changes in ATP, GSH, Hcy, and Cys levels in a PTZ-induced epileptic zebrafish model and an APAP-induced mouse liver injury tissue section model. These findings underscore the significant potential of probe BCR for early disease diagnosis and therapeutic applications.}, archive = {J_ADVS}, author = {Ting Yu and Yang Li and Jing Li and Yabing Gan and Zhengze Long and Yun Deng and Youyu Zhang and Haitao Li and Peng Yin and Shouzhuo Yao}, doi = {10.1002/advs.202415882}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2415882}, shortjournal = {Adv. Sci.}, title = {Multifunctional fluorescent probe for simultaneous detection of ATP, cys, hcy, and GSH: Advancing insights into epilepsy and liver injury}, volume = {12}, year = {2025}, }
• (2025). Endothelial cpt1a inhibits neonatal hyperoxia-induced pulmonary vascular remodeling by repressing endothelial-mesenchymal transition. ADVS, 12(11), 2415824. (www)

  @article{ , abstract = {Pulmonary hypertension (PH) increases the mortality of preterm infants with bronchopulmonary dysplasia (BPD). There are no curative therapies for this disease. Lung endothelial carnitine palmitoyltransferase 1a (Cpt1a), the rate-limiting enzyme of the carnitine shuttle system, is reduced in a rodent model of BPD. It is unknown whether endothelial Cpt1a reduction causes pulmonary vascular (PV) remodeling. The latter can be the result of endothelial-mesenchymal transition (EndoMT). Here, endothelial cell (EC)-specific Cpt1a KO and WT mice (<12 h old) are exposed to hyperoxia (70% O 2 ) for 14 days and allow them to recover in normoxia until postnatal day 28. Hyperoxia causes PH, which is aggravated in EC-specific Cpt1a KO mice. Upregulating endothelial Cpt1a expression inhibits hyperoxia-induced PV remodeling. Hyperoxia causes lung EndoMT, detected by immunofluorescence, scRNA-sequencing, and EC lineage tracing, which is further increased in EC-specific Cpt1a KO mice. Blocking EndoMT inhibits hyperoxia-induced PV remodeling. Male mice under the same high oxygen conditions develop a higher degree of PH than females, which is associated with reduced endothelial Cpt1a expression. Conclusively, neonatal hyperoxia causes PH by decreasing endothelial Cpt1a expression and upregulating EndoMT. This provides a valuable strategy for developing targeted therapies by upregulating endothelial Cpt1a levels or inhibiting EndoMT to treat BPD-associated PH.}, archive = {J_ADVS}, author = {Xiaoyun Li and Katy Hegarty and Fanjie Lin and Jason L. Chang and Amro Abdalla and Karthik Dhanabalan and Sergey O. Solomevich and Wenliang Song and Karim Roder and Chenrui Yao and Wenju Lu and Peter Carmeliet and Gaurav Choudhary and Phyllis A. Dennery and Hongwei Yao}, doi = {10.1002/advs.202415824}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2415824}, shortjournal = {Adv. Sci.}, title = {Endothelial cpt1a inhibits neonatal hyperoxia-induced pulmonary vascular remodeling by repressing endothelial-mesenchymal transition}, volume = {12}, year = {2025}, }
• (2025). Acid-triggered dual-functional hydrogel platform for enhanced bone regeneration. ADVS, 12(11), 2415772. (www)

  @article{ , abstract = {Stem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant cell transformation should not be ignored. Compared to stem cell implantation, recruitment of endogenous stem cells to injured sites is more critical for in situ bone regeneration. In this study, based on the acidic microenvironment of bone injury, an HG-AA 1:1 -SDF-1α composite hydrogel with a dual-control intelligent switch function is developed by incorporating stromal cell-derived factor (SDF-1α), arginine carbon dots (Arg-CDs), and calcium ions (Ca 2+ ) into the oxidized hyaluronic acid/gelatin methacryloyl (HG) hydrogel. The acidic microenvironment triggers the first switch (Schiff base bond is broken between HG-AA 1:1 and SDF-1α) of HG-AA 1:1 -SDF-1α composite hydrogel to continuously release SDF-1α. Compared to the neutral (pH 7.4) media, the cumulative release of SDF-1α in acidic (pH 5.5) media is ≈2.5 times higher, which enhances the migration and recruitment of endogenous mesenchymal stem cells (MSCs). The recruited MSCs immediately initiate the second switch and metabolize Arg-CDs into the bioactive nitric oxide (NO) in the presence of Ca 2+ , activating NO/cyclic guanosine monophosphate (cGMP) signaling pathway to promote angiogenesis. Therefore, the engineered HG-AA 1:1 -SDF-1α composite hydrogel shows promising potential to achieve “coupling osteogenesis and angiogenesis” for bone regeneration.}, archive = {J_ADVS}, author = {Yao Xiao and Jinjin Ma and Xiaonan Yuan and Huan Wang and Fengyu Ma and Jun Wu and Qianglong Chen and Jie Hu and Lijie Wang and Zhendong Zhang and Chao Wang and Jiaying Li and Weishan Wang and Bin Li}, doi = {10.1002/advs.202415772}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2415772}, shortjournal = {Adv. Sci.}, title = {Acid-triggered dual-functional hydrogel platform for enhanced bone regeneration}, volume = {12}, year = {2025}, }
• (2025). Overcoming energy storage-loss trade-offs in polymer dielectrics through the synergistic tuning of electronic effects in π-conjugated polystyrenes. ADVS, 12(11), 2415738. (www)

  @article{ , abstract = {Achieving high-performance dielectric materials remains a significant challenge due to the inherent trade-offs between high energy storage density and low energy loss. A central difficulty lies in identifying a suitable dipolar unit that can enhance the polarity and dielectric constant of the material while effectively suppressing the high energy losses associated with polarization relaxation, charge injection, and conduction. To address this, a novel strategy is proposed that introduces electron-donating and electron-withdrawing substituents on the benzene ring of polystyrene-based polymers, creating bulky dipole groups that are resistant to reorientation under an electric field. This approach mitigates relaxation losses associated with dipole reorientation and manipulates the band structure via substituent modification to suppress conduction losses. Additionally, the deformation of the π -electron cloud under an electric field enhances the dielectric constant and energy storage density. Ultimately, the optimized chlorostyrene-methyl methacrylate (MMA) copolymer exhibits an 85% discharge efficiency and an energy storage density of 18.3 J cm − 3 , nearly three times that of styrene-based copolymers under the same conditions. This study introduces a new approach for designing high-energy density, low-loss polymer dielectric materials by precisely controlling electron-donating and electron-withdrawing effects to modulate the distribution of π -conjugated electron clouds.}, archive = {J_ADVS}, author = {Yipin Cheng and Honghong Gong and Meirong Zhang and Qinglong Ji and Guanxiang Zhang and Xiao Zhang and Zhicheng Zhang}, doi = {10.1002/advs.202415738}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2415738}, shortjournal = {Adv. Sci.}, title = {Overcoming energy storage-loss trade-offs in polymer dielectrics through the synergistic tuning of electronic effects in π-conjugated polystyrenes}, volume = {12}, year = {2025}, }
• (2025). Prediction of cyclic o6 molecules stabilized by helium under pressure. ADVS, 12(11), 2415517. (www)

  @article{ , abstract = {Oxygen usually exists in the form of diatomic molecules at ambient conditions. At high pressure, it undergoes a series of phase transitions from diatomic O 2 to O 8 cluster and ultimately dissociates into a polymeric O 4 spiral chain structure. Intriguingly, the commonly found cyclic hexameric molecules in other group VIA elements (e.g., S 6 and Se 6 ) are never reported in the bulk oxygen. Through extensive computational crystal structure search, herein it is reported that such hexameric O 6 molecules can exist in a stable compound HeO 3 above 1.9 TPa. The first-principles calculations reveal that, during the reaction by mixing oxygen with helium, the insertion of helium does not only expand the lattice volume, but also relieves the electron lone pair repulsion among diatomic O 2 , and thus significantly promoting the formation of cyclic O 6 molecules. Furthermore, the transition pathway calculations demonstrate that molecular O 2 is dissociated first, and then six oxygen atoms form a polymeric digital 2-shaped intermediate O 6 . Subsequently, each unstable intermediate O 6 decomposes into two intermedia O 3 trimers. Finally, O 3 trimers transform into cyclic O 6 molecules at high pressure. This study expands the known molecular forms of oxygen and suggests a route to the synthesis of intriguing cyclic O 6 molecules.}, archive = {J_ADVS}, author = {Jingyu Hou and Qiang Zhu and Xiao-Ji Weng and Xi Shao and Xiao Dong and Hui-Tian Wang and Xiang-Feng Zhou and Yongjun Tian}, doi = {10.1002/advs.202415517}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2415517}, shortjournal = {Adv. Sci.}, title = {Prediction of cyclic o6 molecules stabilized by helium under pressure}, volume = {12}, year = {2025}, }
• (2025). Wetting and spreading behaviors of impacting metal droplet regulated by 2D ultrasonic field. ADVS, 12(11), 2415138. (www)

  @article{ , abstract = {The wetting and spreading behaviors of metal droplets on solid substrates are critical aspects of additive manufacturing. However, the inherent characteristics of metal droplets, including high surface tension, elevated viscosity, and extreme temperatures, pose significant challenges for wetting and spreading on nonwetting substrates. Herein, this work proposes a strategy that employs a two-dimensional (2D) orthogonal ultrasonic field to construct a vibration deposition substrate with radial vibration amplitude gradient, thereby enhancing the wettability and adhesive strength of impacting metal droplets ejected by a piezoelectric micro-jet device. First, a 2D ultrasonic vibration device is designed based on the combination of longitudinal vibration modes. Additionally, oblique and circular vibration trajectories are synthesized. The vibration amplitude distributions and trajectories of the deposition substrate are verified utilizing the finite element method. Subsequently, the experimental results demonstrate that the contact angle is decreased by 24.7%, the spreading diameter is increased by 10.3%, and the adhesive strength is enhanced by 5.4 times compared to deposition on a static substrate. The 2D ultrasonic field facilitates the transition of metal droplets from a non-wetting state to a wetting state on the nonwetting substrate, which highlights the versatility and adaptability of ultrasonic strategy for expanding the applications of metal droplets.}, archive = {J_ADVS}, author = {Yuzhu Zhao and Shijing Zhang and Jing Li and Jie Deng and Yingxiang Liu}, doi = {10.1002/advs.202415138}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2415138}, shortjournal = {Adv. Sci.}, title = {Wetting and spreading behaviors of impacting metal droplet regulated by 2D ultrasonic field}, volume = {12}, year = {2025}, }
• (2025). Single cell-pair proteomics for decoding immune-cancer cell interactions. ADVS, 12(11), 2414769. (www)

  @article{ , abstract = {The efficacy of cancer immunotherapy is significantly influenced by the heterogeneity of individual tumors and immune responses. To investigate this phenomenon, a microfluidic platform is constructed for profiling immune-cancer cell interactions at the single-cell proteomics level for the first time. Based on the platform, a comprehensive workflow is proposed for achieving accurate single-cell pairing of an immune cell and a cancer cell with low cell damage and high success rate up to 95%, cell pair co-culture, and real-time microscopic monitoring of the cell-pair interactions, cell pair retrieval, mass spectrometry-based proteomic analysis of singe cell pairs, and decoupling of the proteomic information for each cell within the cell pair with the stable-isotope labeling method. With the workflow, the interactions of single natural killer (NK) cells and single K562 tumor cells are investigated based on real-time images and single cell-pair proteomics. Notably, an identification depth of over 1000 protein groups in a single cell-pair is achieved, leading to the discovery of sub-clusters of NK cells with different functions and the identification of important biomarkers for cancer treatments. This demonstrates the unique capability of the present platform in providing substantial and comprehensive datasets for profiling immune-cancer cell interactions, discovering heterogeneous immune responses, and predicting biomarkers in the study of cancer immunotherapy.}, archive = {J_ADVS}, author = {Qin-Qin Xu and Yi-Rong Jiang and Jian-Bo Chen and Jie Wu and Yi-Xue Chen and Qian-Xi Fan and Hui-Feng Wang and Yi Yang and Jian-Zhang Pan and Qun Fang}, doi = {10.1002/advs.202414769}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414769}, shortjournal = {Adv. Sci.}, title = {Single cell-pair proteomics for decoding immune-cancer cell interactions}, volume = {12}, year = {2025}, }
• (2025). Thyroid-targeted nano-bombs empower HIFU for graves' disease. ADVS, 12(11), 2414597. (www)

  @article{ , abstract = {Graves' disease (GD) is an autoimmune disorder with a high incidence rate, particularly affecting women of reproductive age. Current treatment modalities for GD carry significant disadvantages, especially for pregnant or nursing women. As a novel extracorporeal therapeutic technique, high-intensity focused ultrasound (HIFU) shows great promise for treating GD; however, its low treatment efficacy impedes clinical application. In this study, a thyroid-targeted nano-bomb system (PD-PLGA@Si-Ab/PDA-I, PSAPI) is developed to enhance HIFU efficacy and improve therapeutic outcomes for GD. The core structure of PSAPI encapsulates a phase-transition material, perfluorohexane, and the anti-inflammatory drug diclofenac within a poly(lactide-co-glycolide) (PLGA) and silica shell. A polydopamine coating enhances biocompatibility, while iodine loading and thyroid-stimulating hormone receptor (TSHR) antibodies grafting ensure targeted delivery to the thyroid. Robust in vitro and in vivo results demonstrated that PSAPI is highly biocompatible, accumulates in the thyroid within 24 h after administration, and significantly potentiates the therapeutic efficacy of HIFU, resulting in markedly reduced inflammatory responses. Transcriptomic analysis revealed a cellular defense mechanism activated in PSAPI-treated cells following HIFU irradiation, highlighting potential molecular targets for the future development of HIFU-sensitizing agents. The biocompatible PSAPI nano-bomb developed in this study holds great transformative potential, addressing critical gaps in current therapeutic practices for GD.}, archive = {J_ADVS}, author = {Binhao Wang and Zhuobing Yin and Xiangyue You and Hanwei Peng and Ying Jiang}, doi = {10.1002/advs.202414597}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414597}, shortjournal = {Adv. Sci.}, title = {Thyroid-targeted nano-bombs empower HIFU for graves' disease}, volume = {12}, year = {2025}, }
• (2025). Ischemic area-targeting and self-monitoring nanoprobes ameliorate myocardial Ischemia/Reperfusion injury by scavenging ROS and counteracting cardiac inflammation. ADVS, 12(11), 2414518. (www)

  @article{ , abstract = {Precise and effective management of myocardial ischemia/reperfusion injury (MIRI) is still a formidable challenge in clinical practice. Additionally, real-time monitoring of drug aggregation in the MIRI region remains an open question. Herein, a drug delivery system, hesperadin and ICG assembled in PLGA-Se-Se-PEG-IMTP (HI@PSeP-IMTP), is designed to deliver hesperadin and ICG to the MIRI region for in vivo optical imaging tracking and to ameliorate MIRI. The peak aggregation of nanoprobes in the MIRI region is monitored by near-infrared fluorescence and photoacoustic imaging. The maximal fluorescence and photoacoustic signals of the HI@PSeP-IMTP group in the MIRI region rise ≈32% and 40% respectively compared with that of HI@PSeP group. Moreover, HI@PSeP-IMTP effectively mitigates MIRI due to a synergistic integration of diselenide bonds and hesperadin, which can eliminate ROS and suppress cardiac inflammation. Specifically, the expression levels of p-CaMKII, p-IκBα, and p65 in the MIRI region in the HI@PSeP-IMTP group demonstrate a reduction of 30%, 46%, and 42% respectively compared to that of the PBS group. Collectively, HI@PSeP-IMTP provides new insights into the development of drugs integrating diagnosis and treatment for MIRI.}, archive = {J_ADVS}, author = {Xiaobin Ma and Zhijin Fan and Jingyan Peng and Liming Nie}, doi = {10.1002/advs.202414518}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414518}, shortjournal = {Adv. Sci.}, title = {Ischemic area-targeting and self-monitoring nanoprobes ameliorate myocardial Ischemia/Reperfusion injury by scavenging ROS and counteracting cardiac inflammation}, volume = {12}, year = {2025}, }
• (2025). (NH4)2Cd2Cl3F3 and (NH4)2Cd2Br3F3: The first fluoride-containing d10 metal mixed halides exhibiting superior ultraviolet nonlinear optical properties. ADVS, 12(11), 2414503. (www)

  @article{ , abstract = {In the search for new ultraviolet (UV) nonlinear optical (NLO) materials, two novel cadmium mixed halide compounds, (NH 4 ) 2 Cd 2 Cl 3 F 3 and (NH 4 ) 2 Cd 2 Br 3 F 3 , are successfully synthesized via hydrothermal methods. These compounds crystallize in the noncentrosymmetric (NCS) space group, R 32, and are composed of distorted octahedral [CdX 3 F 3 ] (X═Cl or Br) units, which extend into a 3D framework. Remarkably, both compounds demonstrate strong second-harmonic generation (SHG) efficiencies—3.0 and 8.0 times that of KH 2 PO 4 for the Cl- and Br-containing analogs, respectively—with phase-matching behavior observed. The SHG efficiency is attributed to the highly distorted coordination environment of the polarizable d 10 Cd 2+ ions, with (NH 4 ) 2 Cd 2 Br 3 F 3 benefiting further from Br's greater polarizability. Furthermore, these compounds exhibit wide bandgaps exceeding 4.2 eV, making them the first d 10 metal mixed halide systems incorporating fluoride that are suitable for UV NLO applications. With UV absorption cut-off edges as short as 203 nm for (NH 4 ) 2 Cd 2 Cl 3 F 3 and 243 nm for (NH 4 ) 2 Cd 2 Br 3 F 3 , these materials represent a significant advancement in the development of UV-transparent NLO materials. This study introduces a novel synthetic strategy for the design of d 10 mixed halide systems with enhanced optical properties, offering promising candidates for future UV NLO technologies.}, archive = {J_ADVS}, author = {Seunghun Choi and Yang Li and Yunseung Kuk and Kang Min Ok}, doi = {10.1002/advs.202414503}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414503}, shortjournal = {Adv. Sci.}, title = {(NH4)2Cd2Cl3F3 and (NH4)2Cd2Br3F3: The first fluoride-containing d10 metal mixed halides exhibiting superior ultraviolet nonlinear optical properties}, volume = {12}, year = {2025}, }
• (2025). 2D perovskite heterojunction-based self-powered polarized photodetectors with controllable polarization ratio enabled by ferro-pyro-phototronic effect. ADVS, 12(11), 2414422. (www)

  @article{ , abstract = {Metal halide perovskites (MHPs) are commonly used in polarization-sensitive photodetectors (PDs) for applications such as polarization imaging, remote sensing, and optical communication. Although various methods exist to adjust the polarization-sensitive photocurrent, a universal and effective approach for continuous control of MHPs’ optoelectronic and polarized properties is lacking. A universal strategy to electrically modulate the polarization ratio (PR) of self-powered polarized PDs using the ferro-pyro-phototronic effect (FPPE) in 2D perovskites is presented. By varying the amplitude and direction of ferroelectric polarization voltage, the built-in electric field in the heterojunction can be modulated, allowing for controllable PR regulation and adjustable polarization characteristics. Moreover, the polarized pyroelectric photoresponses are realized, significantly enhancing the responsivity, response speed of the polarized PDs. Both the pyroelectric currents and photocurrents exhibit obvious polarization characteristics. This method's versatility is demonstrated by creating three additional quasi-2D MHP ferroelectric-based polarized-sensitive PDs. A proof-of-concept for encrypted optical communication is achieved using the UV-sensitive PDs as light-sensing units. These findings highlight FPPE's potential to enhance ferroelectric device polarization control, enabling high-performance and self-powered polarization photodetection.}, archive = {J_ADVS}, author = {Xiaoran Yang and Binyi Zhou and Meitong Guo and Yao Liu and Ridong Cong and Leipeng Li and Wenqiang Wu and Shufang Wang and Linjuan Guo and Caofeng Pan and Zheng Yang}, doi = {10.1002/advs.202414422}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414422}, shortjournal = {Adv. Sci.}, title = {2D perovskite heterojunction-based self-powered polarized photodetectors with controllable polarization ratio enabled by ferro-pyro-phototronic effect}, volume = {12}, year = {2025}, }
• (2025). In situ analysis of li plating and stripping behaviors under dynamic current conditions for realistic application scenarios. ADVS, 12(11), 2414396. (www)

  @article{ , abstract = {Lithium metal batteries are considered the holy grail for next-generation high-energy systems. However, lithium anode faces poor reversibility, unsatisfying cyclability and rate capability due to its uncontrollable plating/stripping behavior. While galvanostatic conditions are extensively studied, the behavior under more realistic application scenarios with variable inputs are less explored. Here, an in situ imaging platform using in-plane microdevice configurations is developed to effectively investigate Li plating/stripping behavior under dynamic conditions. This platform offers high detectivity for analyzing the nuclei size, density, distribution, and growth location, rate, and mode. It is for the first time revealed that nuclei density and growth locations remain constant and are solely determined by the initial nucleation overpotentials during dynamic plating. A transition in growth modes from uniform granular growth to tip-induced dendrite growth, and finally to directional growth among the dendrites is also observed. Guided by these findings, a dynamic plating protocol is proposed, which can greatly improve the Li reversibility and cycling stability. This work not only provides a novel approach to visualize the evolution of key nucleation and growth parameters, especially under variable inputs, but also offers valuable guidance for the future industrialization of metal batteries and the rational design of charging facilities.}, archive = {J_ADVS}, author = {Yanpeng Guo and Xinqi Wei and Cheng Zeng and Xinyu Ji and Yao Liu and Shuhao Wang and Xizheng Liu and Tianyou Zhai and Huiqiao Li}, doi = {10.1002/advs.202414396}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414396}, shortjournal = {Adv. Sci.}, title = {In situ analysis of li plating and stripping behaviors under dynamic current conditions for realistic application scenarios}, volume = {12}, year = {2025}, }
• (2025). Efficient carbon-based optoelectronic synapses for dynamic visual recognition. ADVS, 12(11), 2414319. (www)

  @article{ , abstract = {The human visual nervous system excels at recognizing and processing external stimuli, essential for various physiological functions. Biomimetic visual systems leverage biological synapse properties to improve memory encoding and perception. Optoelectronic devices mimicking these synapses can enhance wearable electronics, with layered heterojunction materials being ideal materials for optoelectronic synapses due to their tunable properties and biocompatibility. However, conventional synthesis methods are complex and environmentally harmful, leading to issues such as poor stability and low charge transfer efficiency. Therefore, it is imperative to develop a more efficient, convenient, and eco-friendly method for preparing layered heterojunction materials. Here, a one-step ultrasonic method is employed to mix fullerene (C60) with graphene oxide (GO), yielding a homogeneous layered heterojunction composite film via self-assembly. The biomimetic optoelectronic synapse based on this film achieves 97.3% accuracy in dynamic visual recognition tasks and exhibits capabilities such as synaptic plasticity. Experiments utilizing X-ray photoelectron spectroscopy (XPS), X-ray diffraction spectroscopy (XRD), Fourier–transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-vis), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirms stable π-π interactions between GO and C60, facilitating electron transfer and prolonging carrier recombination times. The novel approach leveraging high-density π electron materials advances artificial intelligence and neuromorphic systems.}, archive = {J_ADVS}, author = {Wenhao Liu and Jihong Wang and Jiahao Guo and Lin Wang and Zhen Gu and Huifeng Wang and Haiping Fang}, doi = {10.1002/advs.202414319}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414319}, shortjournal = {Adv. Sci.}, title = {Efficient carbon-based optoelectronic synapses for dynamic visual recognition}, volume = {12}, year = {2025}, }
• (2025). The lactate-primed KAT8‒PCK2 axis exacerbates hepatic ferroptosis during Ischemia/Reperfusion injury by reprogramming OXSM-dependent mitochondrial fatty acid synthesis. ADVS, 12(11), 2414141. (www)

  @article{ , abstract = {Recipients often suffer from hyperlactatemia during liver transplantation (LT), but whether hyperlactatemia exacerbates hepatic ischemia-reperfusion injury (IRI) after donor liver implantation remains unclear. Here, the role of hyperlactatemia in hepatic IRI is explored. In this work, hyperlactatemia is found to exacerbate ferroptosis during hepatic IRI. Lactate-primed lysine acetyltransferase 8 (KAT8) is determined to directly lactylate mitochondrial phosphoenolpyruvate carboxykinase 2 (PCK2) at Lys100 and augments PCK2 kinase activity. By using gene-edited mice, evidence indicating that PCK2 exacerbates hepatic ferroptosis during IRI is generated. Mechanistically, PCK2 lactylate at Lys100 acts as a critical inducer of ferroptosis during IRI by competitively inhibiting the Parkin-mediated polyubiquitination of 3-oxoacyl-ACP synthase (OXSM), thereby leading to metabolic remodeling of mitochondrial fatty acid synthesis (mtFAS) and the potentiation of oxidative phosphorylation and the tricarboxylic acid cycle. More importantly, targeting PCK2 is demonstrated to markedly ameliorate hyperlactatemia-mediated ferroptosis during hepatic IRI. Collectively, the findings support the use of therapeutics targeting PCK2 to suppress hepatic ferroptosis and IRI in patients with hyperlactatemia during LT.}, archive = {J_ADVS}, author = {Jingsheng Yuan and Mingyang Yang and Zhenru Wu and Jun Wu and Kejie Zheng and JiaGuo Wang and Qiwen Zeng and Menglin Chen and Tao Lv and Yujun Shi and Jiayin Yang and Jian Yang}, doi = {10.1002/advs.202414141}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414141}, shortjournal = {Adv. Sci.}, title = {The lactate-primed KAT8‒PCK2 axis exacerbates hepatic ferroptosis during Ischemia/Reperfusion injury by reprogramming OXSM-dependent mitochondrial fatty acid synthesis}, volume = {12}, year = {2025}, }
• (2025). Significant efficiency enhancements in non-Y series acceptors by the addition of outer side chains. ADVS, 12(11), 2414042. (www)

  @article{ , abstract = {Most current highly efficient organic solar cells utilize small molecules like Y6 and its derivatives as electron acceptors in the photoactive layer. In this work, a small molecule acceptor, SC8-IT4F, is developed through outer side chain engineering on the terminal thiophene of a conjugated 6,12-dihydro-dithienoindeno[2,3-d:2′,3′-d′]-s-indaceno[1,2-b:5,6-b′]dithiophene (IDTT) central core. Compared to the reference molecule C8-IT4F, which lacks outer side chains, SC8-IT4F displays notable differences in molecule geometry (as shown by simulations), thermal behavior, single-crystal packing, and film morphology. Blend films of SC8-IT4F and the polymer donor PM6 exhibit larger carrier mobilities, longer carrier lifetimes, and reduced recombination compared to C8-IT4F, resulting in improved device performance. Binary photovoltaic devices based on the PM6:SC8-IT4F films reveal an optimal efficiency over 15%, which is one of the best values for non-Y type small molecule acceptors (SMAs). The resultant devices also show better thermal and operational stability than the control PM6:L8-BO devices. SC8-IT4F and its blend exhibit a higher relative degree of crystallinity and π coherence length, compared to C8-IT4F samples, beneficial for charge transport and device performance. The results indicate that outer side chain engineering on existing small electron acceptors can be a promising molecular design strategy for further pursuing high-performance organic solar cells.}, archive = {J_ADVS}, author = {Qiao He and Wisnu Tantyo Hadmojo and Xiantao Hu and Subhrangsu Mukherjee and Maryam Alqurashi and Wejdan Althobaiti and Catherine S. P. De Castro and Byongkyu Lee and Bowen Ding and Joel Luke and Panagiota Kafourou and Zhuping Fei and Andrew J. P. White and Julien Gorenflot and Florian Glöcklhofer and Frédéric Laquai and Harald Ade and Thomas D. Anthopoulos and Martin Heeney}, doi = {10.1002/advs.202414042}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2414042}, shortjournal = {Adv. Sci.}, title = {Significant efficiency enhancements in non-Y series acceptors by the addition of outer side chains}, volume = {12}, year = {2025}, }
• (2025). Photothermal-responsive soluble microneedle patches for meibomian gland dysfunction therapy. ADVS, 12(11), 2413962. (www)

  @article{ , abstract = {Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease, presenting a challenge for targeted treatment. Traditional topical ocular drug delivery methods often fail to effectively reach the meibomian glands (MGs). To address this, the study has developed a soluble microneedles (MN) patch comprising poly(vinyl alcohol), cyclodextrin modified polyacrylic acid, and new indocyanine green. This innovative MN patch facilitates the transdermal release of peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists, such as rosiglitazone in response to near-infrared ray induced temperature changes. By safely optimizing temperature, the patch effectively liquefied meibum lips, thereby alleviating duct obstruction while releasing the drug. MN patches exhibit sufficient mechanical strength for effective skin penetration, and its biosafety for eyelid application has been rigorously assessed in vitro and in vivo. The therapeutic efficiency of rosiglitazone loaded MN (ROSI-MN) treatment for MGD is evaluated in high-fat mice. After three months of treatments, ROSI-MN administration significantly alleviated MGD clinical manifestations, including ocular surface damage, lipid deposits, glandular hypertrophy, and inflammatory infiltration, ultimately improving the microstructure and biofunction of MGs. In conclusion, the soluble MN patches hold promise as an effective drug delivery strategy for treating ocular surface diseases beyond MGD.}, archive = {J_ADVS}, author = {Fei Yu and Xuan Zhao and Qian Wang and Yifei Niu and Peng Xiao and Jinze Zhang and Keyi Fei and Yuancong Huang and Liu Liu and Po-Han Fang and Xinyue Du and Weihua Li and Dalian He and Tingting Zhang and Saiqun Li and Jin Yuan}, doi = {10.1002/advs.202413962}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413962}, shortjournal = {Adv. Sci.}, title = {Photothermal-responsive soluble microneedle patches for meibomian gland dysfunction therapy}, volume = {12}, year = {2025}, }
• (2025). Fabrication of multifunctional three-component supramolecular nano-biscuits via two macrocycles-involved self-assembly for rice, citrus and kiwifruit protections. ADVS, 12(11), 2413826. (www)

  @article{ , abstract = {Bacterial plant diseases, worsened by biofilm-mediated resistance, are increasingly threatening global food security. Numerous attempts have been made to develop agrochemicals that inhibit biofilms, however, their ineffective foliar deposition and difficulty in removing mature biofilms remain major challenges. Herein, multifunctional three-component supramolecular nano-biscuits (NI6R@CB[7]@ β -CD) are successfully engineered via ordered self-assembly between two macrocycles [cucurbit[7]uril (CB[7]), β -cyclodextrin ( β -CD)] and ( R )-2-naphthol-based bis-imidazolium bromide salt (NI6R). This macrocycles-involved bactericidal material combines many advantages. 1) Alleviate the off-target movement of droplets on hydrophobic blade surfaces. 2) Enhance the biofilm-disrupting ability. At a low-dose of 4.44 µg mL −1 , the inhibition rate of biofilm formation reached 78.3%. At 35.5 µg mL −1 , the potency to remove mature biofilms reached 77.6%. 3) Efficiently hinder bacterial reproduction, swimming, extracellular polysaccharide production, extracellular enzyme secretion, and virulence to plants. These superior characteristics are undoubtedly transmitted to the in vivo control effect. At 200 µg mL −1 , this smart material exhibits superior control efficiencies of 49.6%/65.0%/85.4% against three kinds of bacterial diseases (rice leaf blight, citrus canker, and kiwifruit canker), respectively, surpassing the commercial bactericide—thiodiazole-copper-20%SC (33.6%/41.5%/43.2%) and NI6R (40.3%/51.2%/71.2%). Furthermore, NI6R@CB[7]@ β -CD is biosafe to non-target organisms. This study is instructive for constructing multifunctional agrochemicals in sustainable crop protection.}, archive = {J_ADVS}, author = {Xinyu He and Jinghan Yang and Xue Chen and Jiajia Chen and Haicong Zhao and Juan Liu and Fengpei Du and Peiyi Wang}, doi = {10.1002/advs.202413826}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413826}, shortjournal = {Adv. Sci.}, title = {Fabrication of multifunctional three-component supramolecular nano-biscuits via two macrocycles-involved self-assembly for rice, citrus and kiwifruit protections}, volume = {12}, year = {2025}, }
• (2025). Ferroelectric and optoelectronic coupling effects in layered ferroelectric semiconductor-based FETs for visual simulation. ADVS, 12(11), 2413808. (www)

  @article{ , abstract = {Controlling polarization states of ferroelectrics can enrich optoelectronic properties and functions, offering a new avenue for designing advanced electronic and optoelectronic devices. Here, ferroelectric semiconductor-based field-effect transistors (FeSFETs) are fabricated, where the channel is a ferroelectric semiconductor (e.g., α-In 2 Se 3 ). Multiple conductance states are achieved in α-In 2 Se 3 -based FeSFETs by controlling the ferroelectric polarization. The on/off current ratio (I on /I off ) is ≈10 5 with a dark current of ≈10 −11 A by applying a single positive gate voltage pulse. Moreover, the device shows excellent endurance and retention performance. In a further step, the carrier transports and corresponding physics mechanism in various polarization states are studied by using Kelvin probe force microscopy (KPFM) and optoelectronic measurements. Finally, the α-In 2 Se 3 -based FETs can be trained. It can recognize handwritten digit images from MNIST dataset with a successful recognition accuracy of ≈95.5%. This work provides a new design idea and theoretical support for advanced optoelectronic devices in the field of in-memory sensing and computing.}, archive = {J_ADVS}, author = {Can Zhao and Zhaotan Gao and Zian Hong and Hongzhi Guo and Zhili Cheng and Yawei Li and Liyan Shang and Liangqing Zhu and Jinzhong Zhang and Zhigao Hu}, doi = {10.1002/advs.202413808}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413808}, shortjournal = {Adv. Sci.}, title = {Ferroelectric and optoelectronic coupling effects in layered ferroelectric semiconductor-based FETs for visual simulation}, volume = {12}, year = {2025}, }
• (2025). Extreme tolerance of nanoparticle-protein corona to ultra-high abundance proteins enhances the depth of serum proteomics. ADVS, 12(11), 2413713. (www)

  @article{ , abstract = {The serum nanoparticle-protein corona (NPC) provides specific disease information, thus opening a new avenue for high-throughput in-depth proteomics to facilitate biomarker discovery. Yet, little is known about the interactions between NPs and proteins, and its role in enhanced depth of serum proteomics. Herein, a series of protein spike-in experiments are conducted to systematically investigate protein depletion and enrichment during NPC formation. Proteomic depth is serum concentration-dependent, and NPC exhibits powerful tolerance to ultra-high abundant proteins. In addition, protein-protein interactions (PPI), especially those involving albumin, play a pivotal role in promoting proteomic depth. Furthermore, a triple-protein assay is established to interrogate the relationship between protein binding affinity and concentration. NPC formation is a product of balancing binding affinity, concentration, and PPI. Overall, this study elucidates how NPs achieve protein depletion and enrichment for enhanced serum proteomic depth to gain a better understanding of NPC as an essential tool of proteome profiling.}, archive = {J_ADVS}, author = {Qiqi Liu and Mengjie Wang and Xin Dai and Shuangqin Li and Haoxiang Guo and Haozhe Huang and Yueli Xie and Chenlu Xu and Yuan Liu and Weihong Tan}, doi = {10.1002/advs.202413713}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413713}, shortjournal = {Adv. Sci.}, title = {Extreme tolerance of nanoparticle-protein corona to ultra-high abundance proteins enhances the depth of serum proteomics}, volume = {12}, year = {2025}, }
• (2025). The innate immune sensor zbp1 mediates central nervous system inflammation induced by angiostrongylus cantonensis by promoting macrophage inflammatory phenotypes. ADVS, 12(11), 2413675. (www)

  @article{ , abstract = {Angiostrongylus cantonensis (AC) is the leading cause of eosinophilic meningoencephalitis worldwide. The neuroimmune interactions between peripheral and central immune systems in angiostrongyliasis remain unclear. In this study, significant infiltration of eosinophils, myeloid cells, macrophages, neutrophils, and Ly6C monocytes is observed in the brains of AC-infected mice, with macrophages being the most abundant. RNA-seq and SMART-seq analysis of pattern recognition receptor (PRR) and DNA sensor gene sets revealed a marked increase in Z-DNA binding protein 1 (Zbp1) expression in infected mice. Confocal microscopy, RT-qPCR, western blotting, and immunohistochemistry further confirmed that Zbp1 is specifically upregulated in macrophages and microglia. Using Zbp1-knockout mice and flow cytometry, it is found that knockout of Zbp1 enhanced lymphocyte infiltration and natural killer cell cytotoxicity, modulating the immune microenvironment in the central nervous system (CNS) during AC infection. Mechanistically, it is revealed that in macrophage Zbp1 directly binds to receptor-interacting protein 3 (RIP3) to promote its phosphorylation, subsequently facilitating the phosphorylation of mixed lineage kinase domain-like protein (Mlkl). The activated Zbp1-pRIP3-pMlkl axis leads to necroptosis and upregulates pro-inflammatory cytokines including TNF-α, IL-1α, CXCL9, CXCL10 in macrophages, which recruits and activates immune cells. These findings offer new insights into the pathogenic mechanisms of angiostrongyliasis and suggest potential therapeutic strategies.}, archive = {J_ADVS}, author = {Hongli Zhou and Minyu Zhou and XiPing Liao and Liangyu Zhang and Hang Wei and Yuting Lu and Yiqing Zhang and Hui Huang and Yue Hu and Tao Chen and Zhiyue Lv}, doi = {10.1002/advs.202413675}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413675}, shortjournal = {Adv. Sci.}, title = {The innate immune sensor zbp1 mediates central nervous system inflammation induced by angiostrongylus cantonensis by promoting macrophage inflammatory phenotypes}, volume = {12}, year = {2025}, }
• (2025). All-optical modulation photodetectors based on the CdS/Graphene/Ge sandwich structures for integrated sensing-computing. ADVS, 12(11), 2413662. (www)

  @article{ , abstract = {In this manuscript, an all-optical modulation photodetector based on a CdS/graphene/Ge sandwich structure is designed. In the presence of the modulation (near-infrared) light, the Fermi level of the graphene channel shifts, allowing for the tuning of the visible light response speed as well as achieving a broad responsivity range from negative (-3376 A/W) to positive (3584 A/W) response. Based on this, logical operations are performed by adjusting the power of the modulation light superimposed with the signal light. This facilitates more covert, all-optical, high-speed encrypted communication. The ultrahigh tunability and nearly symmetric positive and negative photoconductivity of all-optical modulation photodetectors significantly enhance the computational capacity of neuromorphic hardware. The proposed device exhibits substantial advantages in applications requiring high fault tolerance for integrated sensing-computing （ISC） and high-resolution motion object recognition, providing insights for the development of next-generation high-bandwidth, low-power-consumption ISC devices.}, archive = {J_ADVS}, author = {Qi Yang and Jie Hu and Haozhou Li and Qing Du and Shuanglong Feng and Dong Yang and Yupeng Zhang and Jun Shen}, doi = {10.1002/advs.202413662}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413662}, shortjournal = {Adv. Sci.}, title = {All-optical modulation photodetectors based on the CdS/Graphene/Ge sandwich structures for integrated sensing-computing}, volume = {12}, year = {2025}, }
• (2025). Epigenetic impacts of non-coding mutations deciphered through pre-trained DNA language model at single-cell resolution. ADVS, 12(11), 2413571. (www)

  @article{ , abstract = {DNA methylation plays a critical role in gene regulation, affecting cellular differentiation and disease progression, particularly in non-coding regions. However, predicting the epigenetic consequences of non-coding mutations at single-cell resolution remains a challenge. Existing tools have limited prediction capacity and struggle to capture dynamic, cell-type-specific regulatory changes that are crucial for understanding disease mechanisms. Here, Methven, a deep learning framework designed is presented to predict the effects of non-coding mutations on DNA methylation at single-cell resolution. Methven integrates DNA sequence with single-cell ATAC-seq data and models SNP-CpG interactions over 100 kbp genomic distances. By using a divide-and-conquer approach, Methven accurately predicts both short- and long-range regulatory interactions and leverages the pre-trained DNA language model for enhanced precision in classification and regression tasks. Methven outperforms existing methods and demonstrates robust generalizability to monocyte datasets. Importantly, it identifies CpG sites associated with rheumatoid arthritis, revealing key pathways involved in immune regulation and disease progression. Methven's ability to detect progressive epigenetic changes provides crucial insights into gene regulation in complex diseases. These findings demonstrate Methven's potential as a powerful tool for basic research and clinical applications, advancing this understanding of non-coding mutations and their role in disease, while offering new opportunities for personalized medicine.}, archive = {J_ADVS}, author = {Zhe Liu and An Gu and Yihang Bao and Guan Ning Lin}, doi = {10.1002/advs.202413571}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413571}, shortjournal = {Adv. Sci.}, title = {Epigenetic impacts of non-coding mutations deciphered through pre-trained DNA language model at single-cell resolution}, volume = {12}, year = {2025}, }
• (2025). Integration of phytomelatonin signaling with jasmonic acid in wound-induced adventitious root regeneration. ADVS, 12(11), 2413485. (www)

  @article{ , abstract = {Plants exhibit remarkable regenerative abilities under stress conditions like injury, herbivory, and damage from harsh weather, particularly through adventitious root formation. They have sophisticated molecular mechanisms to recognize and respond to wounding. Jasmonic acid (JA), a wound hormone, triggers auxin synthesis to stimulate root regeneration. Melatonin (MT), structurally similar to auxin, also significantly influences root induction, but its specific mechanism is unclear. Phytomelatonin's signal transduction is discovered in wound-induced root formation, identifying SlPMTR1/2 as phytomelatonin receptors, transmitting signals to SHOOT BORNE ROOTLESS 1 (SlSBRL1), a key regulator of wound-induced root regeneration, via the G protein α subunit 1 (SlGPA1). Additionally, SlPMTR1/2 is activated by JA, and targeted by SlMYC2. Overall, the specific mechanisms of phytomelatonin on wound-induced root regeneration is uncovered and revealed a crosstalk between phytomelatonin and JA, offering new insights into plant repair mechanisms.}, archive = {J_ADVS}, author = {Ying Liu and Xiaoyun Wang and Shirui Jing and Congyang Jia and Hongxin Li and Chonghua Li and Qiuyu He and Na Zhang and Yang-Dong Guo}, doi = {10.1002/advs.202413485}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413485}, shortjournal = {Adv. Sci.}, title = {Integration of phytomelatonin signaling with jasmonic acid in wound-induced adventitious root regeneration}, volume = {12}, year = {2025}, }
• (2025). Beam scanning with ultra-low sidelobes and in-band ultra-low scattering characteristics empowered by single space-time-coding radiation-scattering metasurface. ADVS, 12(11), 2413429. (www)

  @article{ , abstract = {The integrated modulation of radiation and scattering provides an unprecedented opportunity to reduce the number of electromagnetic (EM) apertures in the platform while simultaneously enhancing communication and stealth performance. Nevertheless, achieving full-polarization, arbitrary amplitude, and phase modulation of radiation scattering remains a challenge. In this paper, a strategy that realizes space-time coding of radiation scattering within the same frequency band, which enables the simultaneous and independent modulation of amplitude and phase, is proposed. To address the limitations of the high sideband levels (SBLs) of conventional space-time-coding metasurfaces, a strategy comprising nonuniform modulation periods and stochastic coding is proposed. Consequently, beam scanning with ultra-low sidelobe levels (SLLs) and suppressed SBLs is achieved in the radiation mode (RM). In scattering mode (SM), in-band low scattering characteristics are achieved within the same operating frequency band as RM. A prototype of a space-time-coding radiation-scattering metasurface (STCRSM) is fabricated and the aforementioned functionalities are validated by measurements. Furthermore, the proposed strategy does not necessitate the utilization of optimization algorithms and exhibits low SLLs and low SBLs, which will make it flourish in RF stealth applications, such as covert communication systems.}, archive = {J_ADVS}, author = {Lixin Jiang and Yongfeng Li and Hao Yang and Mingbao Yan and Jinming Jiang and Yunwei Zhang and Zhe Qin and Wanwan Yang and Hongya Chen and Yongqiang Pang and Zhihao Guo and Lin Zheng and Jiafu Wang and Shaobo Qu}, doi = {10.1002/advs.202413429}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413429}, shortjournal = {Adv. Sci.}, title = {Beam scanning with ultra-low sidelobes and in-band ultra-low scattering characteristics empowered by single space-time-coding radiation-scattering metasurface}, volume = {12}, year = {2025}, }
• (2025). Phonon involved photoluminescence of mn2+ ions doped CsPbCl3 micro-size perovskite assembled crystals. ADVS, 12(11), 2413402. (www)

  @article{ , abstract = {Mn 2+ ions doped CsPbCl 3 perovskite nanocrystals (NCs) exhibit superiority of spin-associated optical and electrical properties. However, precisely controlling the doping concentration, doping location, and the mono-distribution of Mn 2+ ions in the large-micro-size CsPbCl 3 perovskite host is a formidable challenge. Here, the micro size CsPbCl 3 perovskite crystals (MCs) are reported with uniform Mn 2+ ions doping by self-assembly of Mn 2+ ions doped CsPbCl 3 perovskite NCs. The electron–phonon coupling strength is enhanced in the perovskite self-assembled CsPbCl 3 MCs, which remarkably accelerates the PL decay of Mn 2+ ions in room temperature. Furthermore, the phonon-involved PL emission splits to two peaks at low temperature of 80 K, due to the phonon emission and absorption-induced energy exchange for exciton recombination in Mn 2+ ions. These findings not only demonstrate a novel material system but also introduce a new theoretical framework for phonon-modulated PL manipulation in Mn 2+ -doped perovskite materials.}, archive = {J_ADVS}, author = {Jialiang Gao and Yangyang Guo and Xiuhai Zhang and Lu Liu and Huixin Li and Zeyi Cheng and Peng Liu and Fan Dong and Jiandong Wu and Taihong Liu and Huaming Sun and Miao Zhang and Hervé Aubin and Hongyue Wang and Hongqiang Wang}, doi = {10.1002/advs.202413402}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413402}, shortjournal = {Adv. Sci.}, title = {Phonon involved photoluminescence of mn2+ ions doped CsPbCl3 micro-size perovskite assembled crystals}, volume = {12}, year = {2025}, }
• (2025). Transfusion-related acute lung injury: From mechanistic insights to therapeutic strategies. ADVS, 12(11), 2413364. (www)

  @article{ , abstract = {Transfusion-related acute lung injury (TRALI) is a potentially lethal complication of blood transfusions, characterized by the rapid onset of pulmonary edema and hypoxemia within six hours post-transfusion. As one of the primary causes of transfusion-related mortality, TRALI carries a significant mortality rate of 6–12%. However, effective treatment strategies for TRALI are currently lacking, underscoring the urgent need for a comprehensive and in-depth understanding of its pathogenesis. This comprehensive review provides an updated and detailed analysis of the current landscape of TRALI, including its clinical presentation, pathogenetic hypotheses, animal models, cellular mechanisms, signaling pathways, and potential therapeutic targets. By highlighting the critical roles of these pathways and therapies, this review offers valuable insights to inform the development of preventative and therapeutic strategies and to guide future research efforts aimed at addressing this life-threatening condition.}, archive = {J_ADVS}, author = {Xiaobin Fang and Chunheng Mo and Ling Zheng and Fei Gao and Fu-Shan Xue and Xiaochun Zheng}, doi = {10.1002/advs.202413364}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413364}, shortjournal = {Adv. Sci.}, title = {Transfusion-related acute lung injury: From mechanistic insights to therapeutic strategies}, volume = {12}, year = {2025}, }
• (2025). Optimizing biomimetic 3D disordered fibrous network structures for lightweight, high-strength materials via deep reinforcement learning. ADVS, 12(11), 2413293. (www)

  @article{ , abstract = {3D disordered fibrous network structures (3D-DFNS), such as cytoskeletons, collagen matrices, and spider webs, exhibit remarkable material efficiency, lightweight properties, and mechanical adaptability. Despite their widespread in nature, the integration into engineered materials is limited by the lack of study on their complex architectures. This study addresses the challenge by investigating the structure-property relationships and stability of biomimetic 3D-DFNS using large datasets generated through procedural modeling, coarse-grained molecular dynamics simulations, and machine learning. Based on these datasets, a network deep reinforcement learning (N-DRL) framework is developed to optimize its stability, effectively balancing weight reduction with the maintenance of structural integrity. The results reveal a pronounced correlation between the total fiber length in 3D-DFNS and its mechanical properties, where longer fibers enhance stress distribution and stability. Additionally, fiber orientation is also considered as a potential factor influencing stress growth values. Furthermore, the N-DRL model demonstrates superior performance compared to traditional approaches in optimizing network stability while minimizing mass and computational cost. Structural integrity is significantly improved through the addition of triple junctions and the reduction of higher-order nodes. In summary, this study leverages machine learning to optimize biomimetic 3D-DFNS, providing novel insights into the design of lightweight, high-strength materials.}, archive = {J_ADVS}, author = {Yunhao Yang and Runnan Bai and Wenli Gao and Leitao Cao and Jing Ren and Zhengzhong Shao and Shengjie Ling}, doi = {10.1002/advs.202413293}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413293}, shortjournal = {Adv. Sci.}, title = {Optimizing biomimetic 3D disordered fibrous network structures for lightweight, high-strength materials via deep reinforcement learning}, volume = {12}, year = {2025}, }
• (2025). α-lipoic acid ameliorates arsenic-induced lipid disorders by promoting peroxisomal β-oxidation and reducing lipophagy in chicken hepatocyte. ADVS, 12(11), 2413255. (www)

  @article{ , abstract = {Liver disease poses a significant threat to global public health, with arsenic (As) recognized as a major environmental toxin contributing to liver injury. However, the specific mechanisms and the protective effects of α-lipoic acid (LA) remain unclear. Therefore, this study employs network toxicology and network pharmacology to comprehensively analyze the hepatotoxic mechanism of As and the hepatoprotective mechanism of LA, and further verifies the mechanisms of peroxisomal β-oxidation and lipophagy in the process. The network analysis results show that As induces liver damage mainly through autophagy, apoptosis, lipid metabolism, and oxidative stress, whereas LA exerts its hepatoprotective properties mainly by regulating lipid metabolism. Further verifications find that As inhibits SIRT1 expression, activates the P53 and Notch pathways, damages mitochondria, inhibits peroxisomal β-oxidation, increases lipid accumulation, and enhances lipophagy in the liver, while LA intervention alleviates As-induced lipid accumulation and enhances lipophagy by targeting SIRT1, ameliorating mitochondrial damage, enhancing peroxisomal β-oxidation, thereby alleviating As-induced liver damage. This study further clarifies the mechanism of As hepatotoxicity and provides a theoretical basis for LA as a potential hepatoprotective agent.}, archive = {J_ADVS}, author = {Yangfei Zhao and Mingyue Guo and Ting Pei and Chenqi Shang and Yirong Chen and Liying Zhao and Yiguang Lu and Chen Liang and Jundong Wang and Jianhai Zhang}, doi = {10.1002/advs.202413255}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413255}, shortjournal = {Adv. Sci.}, title = {α-lipoic acid ameliorates arsenic-induced lipid disorders by promoting peroxisomal β-oxidation and reducing lipophagy in chicken hepatocyte}, volume = {12}, year = {2025}, }
• (2025). Functional characterization of an aldol condensation synthase PheG for the formation of hispidin from phellinus igniarius. ADVS, 12(11), 2413192. (www)

  @article{ , abstract = {Hispidin ( 1 ) is a polyphenolic compound with a wide range of pharmacological activities that is distributed in both plants and fungi. In addition to natural extraction, hispidin can be obtained by chemical or enzymatic synthesis. In this study, the identification and characterization of an undescribed enzyme, PheG, from Phellinus igniarius ( P. igniarius ), which catalyzes the construction of a key C─C bond in the enzymatic synthesis of hispidin are reported. It is demonstrated in vitro that PheG generates hispidin by catalyzing C─C bond formation in the aldol condensation reaction. Based on these results, a plausible pathway for hispidin biosynthesis is proposed by utilizing the primary triacetic acid lactone (TAL, 2 ) and 3,4-dihydroxybenzaldehyde ( 3 ). The mechanisms for the aldol condensation reaction of PheG are investigated using molecular dynamics (MD) simulations, molecular mechanics/generalized Born surface area (MM/GBSA) binding free energy calculations, density functional theory, and site-specific mutations. The locations of the key amino acid residues that catalyze the conversion of substrates 2 and 3 to hispidin at the active site of PheG-1 are identified. This study provides a new method for preparing hispidin with high efficiency and low cost.}, archive = {J_ADVS}, author = {Wanting Zhang and Ruliang Zheng and Weiling Geng and Xinyuan Wu and Xiaojuan Gao and Li Zhou and Zhenyu An and Cheng Liu and Zhijun Song and Hongyan Ji and Hao Yang and Xiuli Wu}, doi = {10.1002/advs.202413192}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413192}, shortjournal = {Adv. Sci.}, title = {Functional characterization of an aldol condensation synthase PheG for the formation of hispidin from phellinus igniarius}, volume = {12}, year = {2025}, }
• (2025). Structural insights into the substrate recognition of ginsenoside glycosyltransferase pq3-O-UGT2. ADVS, 12(11), 2413185. (www)

  @article{ , abstract = {Ginsenosides are a group of tetracyclic triterpenoids with promising health benefits, consisting of ginseng aglycone attached to various glycans. Pq3-O-UGT2, an important UDP-dependent glycosyltransferase (UGT), catalyzes the production of Ginsenoside Rg3 and Rd by extending the glycan chain of Ginsenoside Rh2 and F2, respectively, with higher selectivity for F2. However, the mechanism underlying its substrate recognition remains unclear. In this study, the crystal structures of Pq3-O-UGT2 in complex with its acceptor substrates are solved. The structures revealed a Nα5-oriented acceptor binding pocket in Pq3-O-UGT2, shaped by the unique conformation of the Nα5-Nα6 linker. Hydrophobic interactions play a pivotal role in the recognition of both Rh2 and F2, while hydrogen bonds specifically aid in F2 recognition due to its additional glucose moiety. The hydrophobic nature of the acceptor binding pocket also enables Pq3-O-UGT2 to recognize flavonoids. Overall, this study provides novel insights into the substrate recognition mechanisms of ginsenoside UGTs, advancing the understanding of their function and specificity.}, archive = {J_ADVS}, author = {Qiushuang Ji and Yirong Liu and Huanyu Zhang and Yan Gao and Yixin Ding and Yuanyuan Ding and Jing Xie and Jianyu Zhang and Xinghua Jin and Bin Lai and Cheng Chen and Juan Wang and Wenyuan Gao and Kunrong Mei}, doi = {10.1002/advs.202413185}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413185}, shortjournal = {Adv. Sci.}, title = {Structural insights into the substrate recognition of ginsenoside glycosyltransferase pq3-O-UGT2}, volume = {12}, year = {2025}, }
• (2025). The metabolite indole-3-acetic acid of bacteroides ovatus improves atherosclerosis by restoring the polarisation balance of M1/M2 macrophages and inhibiting inflammation. ADVS, 12(11), 2413010. (www)

  @article{ , abstract = {Emerging research has highlighted the significant role of the gut microbiota in atherosclerosis (AS), with microbiota-targeted interventions offering promising therapeutic potential. A central component of this process is gut-derived metabolites, which play a crucial role in mediating the distal functioning of the microbiota. In this study, a comprehensive microbiome-metabolite analysis using fecal and serum samples from patients with atherosclerotic cardiovascular disease and volunteers with risk factors for coronary heart disease and culture histology is performed, and identified the core strain Bacteroides ovatus ( B. ovatus ). Fecal microbiota transplantation experiments further demonstrated that the gut microbiota significantly influences AS progression, with B. ovatus alone exerting effects comparable to volunteer feces from volunteers. Notably, B. ovatus alleviated AS primarily by restoring the intestinal barrier and enhancing bile acid metabolism, particularly through the production of indole-3-acetic acid (IAA), a tryptophan-derived metabolite. IAA inhibited the TLR4/MyD88/NF-κB pathway in M1 macrophages, promoted M2 macrophage polarisation, and restored the M1/M2 polarisation balance, ultimately reducing aortic inflammation. These findings clarify the mechanistic interplay between the gut microbiota and AS, providing the first evidence that B. ovatus , a second-generation probiotic, can improve bile acid metabolism and reduce inflammation, offering a theoretical foundation for future AS therapeutic applications involving this strain.}, archive = {J_ADVS}, author = {Wu Liu and Jingyu Wang and Heng Yang and Congcong Li and Wanqi Lan and Tingtao Chen and Yanhua Tang}, doi = {10.1002/advs.202413010}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2413010}, shortjournal = {Adv. Sci.}, title = {The metabolite indole-3-acetic acid of bacteroides ovatus improves atherosclerosis by restoring the polarisation balance of M1/M2 macrophages and inhibiting inflammation}, volume = {12}, year = {2025}, }
• (2025). Mitochondrial protein MjEF-tu is secreted into host plants by nematodes eliciting immune signaling and resistance. ADVS, 12(11), 2412968. (www)

  @article{ , abstract = {Little is known about plant-parasitic animal-derived pathogen-associated molecular pattern (PAMP)/ pattern-recognition receptor (PRR) pairs. Additionally, mitochondrial proteins have not previously been reported to be secreted into hosts by pathogens. Here, it is found that the Meloidogyne javanica elongation factor thermo unstable (EF-Tu) (MjEF-Tu) located in the nematode mitochondria is up-regulated and secreted into the host plant during nematode parasitism. MjEF-Tu interacts with the PRR Arabidopsis thaliana EF-Tu receptor (AtEFR), triggering the plant hallmark defence responses mediated by AtEFR. An 18-aa sequence (Nelf18) in the N terminus of the nematode EF-Tu contributes to the immunogenic activity. M. javanica water extract and mitochondrial extract also induce plant immunity sensed by AtEFR, owing to the presence of MjEF-Tu. In addition, Nelf18 enhances plant resistance to nematode, virus, and bacterial infections depending on AtEFR. These findings first demonstrate that mitochondrial proteins from pathogens can be secreted into hosts and function as a cross-kingdom signal and identified the first plant-parasitic animal-derived proteinaceous PAMP/PRR pair, providing novel insights into host-pathogen interactions.}, archive = {J_ADVS}, author = {Borong Lin and Shaozhen Huang and Zhiwen Li and Qiuling Huang and Handa Song and Tianyi Fang and Jinling Liao and Godelieve Gheysen and Kan Zhuo}, doi = {10.1002/advs.202412968}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412968}, shortjournal = {Adv. Sci.}, title = {Mitochondrial protein MjEF-tu is secreted into host plants by nematodes eliciting immune signaling and resistance}, volume = {12}, year = {2025}, }
• (2025). Nanodrugs targeting key factors of ferroptosis regulation for enhanced treatment of osteoarthritis. ADVS, 12(11), 2412817. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a globally prevalent degenerative joint disease. Recent studies highlight the role of ferroptosis in OA progression. Targeting ferroptosis regulation presents a promising therapeutic strategy for OA; however, current research primarily focuses on single targets associated with ferroptosis. In this study, a reactive oxygen species (ROS)-responsive nanoparticle is developed by linking deferasirox (DEF) and pterostilbene (PTE) with thioketal and incorporating cerium ions (Ce), creating Ce@D&P nanoparticles (NPs), which offer multitarget regulation of ferroptosis. The characteristics of Ce@D&P NPs are evaluated and their therapeutic effects on IL-1β-stimulated chondrocytes are verified. Results show that Ce@D&P NPs reduce ROS levels, mitigate inflammation, chelate iron to inhibit ferroptosis, and balance extracellular matrix (ECM) metabolism in chondrocytes. Mechanistically, transcriptomics and metabolomics analyses suggest that Ce@D&P NPs exerted their effects by regulating oxidative stress and lipid metabolism in chondrocytes. To better treat destabilization of the medial meniscus (DMM)-induced OA in mice, Ce@D&P NPs via intra-articular injection are delivered. The results show that Ce@D&P NPs alleviate cartilage matrix damage and slow OA progression. Overall, the findings indicate that Ce@D&P NPs represent a promising multitarget drug delivery system, and Ce@D&P NPs may be an effective strategy for OA treatment.}, archive = {J_ADVS}, author = {Dong Wang and Yanli Pan and Wenzhe Chen and Du He and Weihui Qi and Jiali Chen and Wenhua Yuan and Yimin Yang and Di Chen and Pinger Wang and Hongting Jin}, doi = {10.1002/advs.202412817}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412817}, shortjournal = {Adv. Sci.}, title = {Nanodrugs targeting key factors of ferroptosis regulation for enhanced treatment of osteoarthritis}, volume = {12}, year = {2025}, }
• (2025). Active nematics reinforce the ratchet flow in dense environments without jamming. ADVS, 12(11), 2412750. (www)

  @article{ , abstract = {The past decade witnessed a surge in discoveries where biological systems, such as bacteria or living cells, inherently portray active polar or nematic behavior: they prefer to align with each other and form local order during migration. Although the underlying mechanisms remain unclear, utilizing their physical properties to achieve controllable cell-layer transport will be of fundamental importance. In this study, the ratchet effect is harnessed to control the collective motion of neural progenitor cells (NPCs) in vitro. NPCs travel back-and-forth and do not specify head or tail, and therefore regarded as nematics alike liquid crystals. Ratchet and splay-shaped confinements are crafted to modulate collective cell dynamics in dense environments, while jamming is not explicitly spotted. The adaptation of an agent-based simulation further revealed how the ratchet's asymmetry and active forces from nematic order synergistically reinforce the directional cell flow. These findings provide insights into topotaxis in cell populations when restricted to crowded 2D ratchets and the mechanisms that regulate collective behavior of the cells.}, archive = {J_ADVS}, author = {Yisong Yao and Zihui Zhao and He Li and Yongfeng Zhao and H. P. Zhang and Masaki Sano}, doi = {10.1002/advs.202412750}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412750}, shortjournal = {Adv. Sci.}, title = {Active nematics reinforce the ratchet flow in dense environments without jamming}, volume = {12}, year = {2025}, }
• (2025). 3-HKA promotes vascular remodeling after stroke by modulating the activation of A1/A2 reactive astrocytes. ADVS, 12(11), 2412667. (www)

  @article{ , abstract = {Ischemic stroke is the most common cerebrovascular disease and the leading cause of permanent disability worldwide. Recent studies have shown that stroke development and prognosis are closely related to abnormal tryptophan metabolism. Here, significant downregulation of 3-hydroxy-kynurenamine (3-HKA) in stroke patients and animal models is identified. Supplementation with 3-HKA improved long-term neurological recovery, reduced infarct volume, and increased ipsilateral cerebral blood flow after distal middle cerebral artery occlusion (MCAO). 3-HKA promoted angiogenesis, functional blood vessel formation, and blood-brain barrier (BBB) repair. Moreover, 3-HKA inhibited A1-like (neurotoxic) astrocyte activation but promoted A2-like (neuroprotective) astrocyte polarization. Proteomic analysis revealed that 3-HKA inhibited AIM2 inflammasome activation after stroke, and co-labeling studies indicated that AIM2 expression typically increased in astrocytes at 7 and 14 days after stroke. Consistently, in co-cultures of primary mouse brain microvascular endothelial cells and astrocytes, 3-HKA promoted angiogenesis after oxygen-glucose deprivation (OGD). AIM2 overexpression in astrocytes abrogated 3-HKA-driven vascular remodeling in vitro and in vivo, suggesting that 3-HKA may regulate astrocyte-mediated vascular remodeling by impeding AIM2 inflammasome activation. In conclusion, 3-HKA may promote post-stroke vascular remodeling by regulating A1/A2 astrocyte activation, thereby improving long-term neurological recovery, suggesting that supplementation with 3-HKA may be an efficient therapy for stroke.}, archive = {J_ADVS}, author = {Jun-Min Chen and Guang Shi and Lu-Lu Yu and Wei Shan and Jing-Yu Sun and An-Chen Guo and Jian-Ping Wu and Tie-Shan Tang and Xiang-Jian Zhang and Qun Wang}, doi = {10.1002/advs.202412667}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412667}, shortjournal = {Adv. Sci.}, title = {3-HKA promotes vascular remodeling after stroke by modulating the activation of A1/A2 reactive astrocytes}, volume = {12}, year = {2025}, }
• (2025). Powering the future: Opportunities and obstacles in lead-halide inorganic perovskite solar cells. ADVS, 12(11), 2412666. (www)

  @article{ , abstract = {Efficiency, stability, and cost are crucial considerations in the development of photovoltaic technology for commercialization. Perovskite solar cells (PSCs) are a promising third-generation photovoltaic technology due to their high efficiency and low-cost potential. However, the stability of organohalide perovskites remains a significant challenge. Inorganic perovskites, based on CsPbX ₃ (X = Br − /I − ), have garnered attention for their excellent thermal stability and optoelectronic properties comparable to those of organohalide perovskites. Nevertheless, the development of inorganic perovskites faces several hurdles, including the need for high-temperature annealing to achieve the photoactive α-phase and their susceptibility to transitioning into the nonphotoactive δ-phase under environmental stressors, particularly moisture. These challenges impede the creation of high-efficiency, high-stability devices using low-cost, scalable manufacturing processes. This review provides a comprehensive background on the fundamental structural, physical, and optoelectronic properties of inorganic lead-halide perovskites. It discusses the latest advancements in fabricating inorganic PSCs at lower temperatures and under ambient conditions. Furthermore, it highlights the progress in state-of-the-art inorganic devices, particularly those manufactured in ambient environments and at reduced temperatures, alongside simultaneous advancements in the upscaling and stability of inorganic PSCs.}, archive = {J_ADVS}, author = {Narendra Pai and Dechan Angmo}, doi = {10.1002/advs.202412666}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412666}, shortjournal = {Adv. Sci.}, title = {Powering the future: Opportunities and obstacles in lead-halide inorganic perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). “Popping the ion-basket”: Enhancing thermoelectric performance of conjugated polymers by blending with latently dissociable perovskite quantum dots. ADVS, 12(11), 2412663. (www)

  @article{ , abstract = {A novel additive method to boost the Seebeck coefficient of doped conjugated polymers without a significant loss in electrical conductivity is demonstrated. Perovskite (CsPbBr 3 ) quantum dots (QDs) passivated by ligands with long alkyl chains are mixed with a conjugated polymer in a solution phase to form polymer-QD blend films. Solution sequential doping of the blend film with AuCl 3 solution not only doped the conjugated polymer but also decomposed the QDs, resulting in a doped conjugated polymer film embedded with separated ions dissociated from the QDs. For the doped polymer-molten QD blend films with the optimal QD content, it is found that a greatly enhanced Seebeck coefficient is achieved compared to that of the doped polymer film without QDs, while the doping level and electrical conductivity are not significantly reduced by the QD incorporation. Consequently, the power factor is enhanced, reaching a remarkably high value of up to 401.9 µW m −1 K −2 (≈155% increase with the QDs). The applicability of this method to a variety of conjugated polymers is also demonstrated. The enhancement in the Seebeck coefficient is attributed to ion-induced local variations in the polymer work function, which generates an internal energy barrier for charge transport and causes an energy filtering effect.}, archive = {J_ADVS}, author = {Hansol Lee and Hoimin Kim and Haedam Jin and Seungju Kang and Tae Woong Yoon and Dongki Lee and Guobing Zhang and Min Kim and Boseok Kang}, doi = {10.1002/advs.202412663}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412663}, shortjournal = {Adv. Sci.}, title = {“Popping the ion-basket”: Enhancing thermoelectric performance of conjugated polymers by blending with latently dissociable perovskite quantum dots}, volume = {12}, year = {2025}, }
• (2025). Observations of cherenkov-like radial wake in water waves. ADVS, 12(11), 2412638. (www)

  @article{ , abstract = {Cherenkov radiation (CR) is a fascinating phenomenon that occurs not only in electromagnetic (EM) waves but also in water waves. The V-shaped wake formed by a moving object on the water surface results from the constructive interference of water waves of different wavelengths, similar to CR. We designed and fabricated a one-dimensional (1D) water wave crystal to analogize the behavior of moving particles in water waves. This crystal exhibits a band structure with both positive (positive group velocity) and negative slopes (negative group velocity), exciting and directing the water waves to produce forward and backward radiating wakes through a mechanism similar to CR. Notably, the radiation angle is easily adjustable. This method of regulating water wave wakes holds potential applications in scattering cancellation-based wake stealth, navigation technology, and fluid dynamics for future offshore vessels.}, archive = {J_ADVS}, author = {Zijian Qin and Lian Shen and Yihao Yang and Hongsheng Chen and Huaping Wang}, doi = {10.1002/advs.202412638}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412638}, shortjournal = {Adv. Sci.}, title = {Observations of cherenkov-like radial wake in water waves}, volume = {12}, year = {2025}, }
• (2025). Unveiling a tunable moiré bandgap in bilayer Graphene/hBN device by angle-resolved photoemission spectroscopy. ADVS, 12(11), 2412609. (www)

  @article{ , abstract = {Over the years, great efforts have been devoted in introducing a sizable and tunable band gap in graphene for its potential application in next-generation electronic devices. The primary challenge in modulating this gap has been the absence of a direct method for observing changes of the band gap in momentum space. In this study, advanced spatial- and angle-resolved photoemission spectroscopy technique is employed to directly visualize the gap formation in bilayer graphene, modulated by both displacement fields and moiré potentials. The application of displacement field via in situ electrostatic gating introduces a sizable and tunable electronic bandgap, proportional to the field strength up to 100 meV. Meanwhile, the moiré potential, induced by aligning the underlying hexagonal boron nitride substrate, extends the bandgap by ≈20 meV. Theoretical calculations effectively capture the experimental observations. This investigation provides a quantitative understanding of how these two mechanisms collaboratively modulate the band gap in bilayer graphene, offering valuable guidance for the design of graphene-based electronic devices.}, archive = {J_ADVS}, author = {Hanbo Xiao and Han Gao and Min Li and Fanqiang Chen and Qiao Li and Yiwei Li and Can Li and Meixiao Wang and Fangyuan Zhu and Lexian Yang and Shiyong Wang and Feng Miao and Yulin Chen and Cheng Chen and Bin Cheng and Jianpeng Liu and Zhongkai Liu}, doi = {10.1002/advs.202412609}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412609}, shortjournal = {Adv. Sci.}, title = {Unveiling a tunable moiré bandgap in bilayer Graphene/hBN device by angle-resolved photoemission spectroscopy}, volume = {12}, year = {2025}, }
• (2025). Integrative transcriptome-wide association study with expression quantitative trait loci colocalization identifies a causal VAMP8 variant for nasopharyngeal carcinoma susceptibility. ADVS, 12(11), 2412580. (www)

  @article{ , abstract = {Nasopharyngeal carcinoma (NPC) is an Asia-prevalent malignancy, yet its genetic underpinnings remain incompletely understood. Here, a transcriptome-wide association study (TWAS) is conducted on NPC, leveraging gene expression prediction models based on epithelial tissues and genome-wide association study (GWAS) summary statistics from 1577 NPC cases and 6359 controls of southern Chinese descent. The TWAS identifies VAMP8 on chromosome 2p11.2 as a novel susceptibility gene for NPC. Further fine-mapping analyses pinpoint rs1058588, located within VAMP8 , as a causal variant through eQTL colocalization, and GWAS analyses across multiple cohorts, achieving GWAS significance (OR = 1.18, P = 3.09 × 10 −10 ). Functional assays demonstrate that VAMP8 exerts a tumorigenic role in NPC, enhancing cell proliferation, migration, and tumor growth. Mechanically, it is uncovered that rs1058588 modulates VAMP8 expression by altering its binding affinity to miR-185 . Furthermore, the results show that VAMP8 interacts with DHX9 to facilitate the nuclear recruitment of p65, activating the NF-κB pathway. Collectively, the findings shed light on the genetic predisposition to NPC and underscore the critical role of the functional axis involving miR-185, VAMP8, DHX9, and the NF-κB pathway in NPC pathogenesis.}, archive = {J_ADVS}, author = {Yan Liang and Xiang-Yu Xiong and Guo-Wang Lin and Xiaomeng Bai and Fugui Li and Josephine Mun-Yee Ko and Yun-He Zhou and An-Yi Xu and Shu-Qiang Liu and Shuai He and Pan-Pan Wei and Qiu-Yan Chen and Lin-Quan Tang and Vivien Ya-Fan Wang and Hai-Qiang Mai and Chun-Ling Luo and Yanni Zeng and Maria Li Lung and Mingfang Ji and Jin-Xin Bei}, doi = {10.1002/advs.202412580}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412580}, shortjournal = {Adv. Sci.}, title = {Integrative transcriptome-wide association study with expression quantitative trait loci colocalization identifies a causal VAMP8 variant for nasopharyngeal carcinoma susceptibility}, volume = {12}, year = {2025}, }
• (2025). Microglia-derived interleukin-6 triggers astrocyte apoptosis in the hippocampus and mediates depression-like behavior. ADVS, 12(11), 2412556. (www)

  @article{ , abstract = {In patients with major depressive disorder (MDD) and animal models of depression, key pathological hallmarks include activation of microglia as well as atrophy and loss of astrocytes. Under certain pathological conditions, microglia can inflict damage to neurons and astrocytes. However, the precise mechanisms underlying how activated microglia induced astrocyte atrophy and loss remain enigmatic. In this study, a depression model induced by chronic social defeat stress (CSDS) is utilized. The results show that CSDS induces significant anxiety- and depression-like behaviors, along with notable astrocyte atrophy and apoptosis, microglial activation, and elevated levels of microglial interleukin-6 (IL-6). Subsequent studies demonstrate that IL-6 released from activated microglia promotes astrocyte apoptosis. Furthermore, the knockdown of the P2X7 receptor (P2X7R) in microglia, which is implicated in the stress response, reduces stress-induced microglial activation, IL-6 release, and astrocyte apoptosis. Direct inhibition of microglia by minocycline corroborates these effects. The selective knockdown of IL-6 in microglia and IL-6 receptors in astrocytes effectively mitigates depression-like behaviors and reduces astrocyte atrophy. This study identifies microglial IL-6 as a key factor that contributes to astrocyte apoptosis and depressive symptoms. Consequently, the IL-6/IL-6R pathway has emerged as a promising target for the treatment of depression.}, archive = {J_ADVS}, author = {Shi-Yu Shen and Ling-Feng Liang and Tian-Le Shi and Zu-Qi Shen and Shu-Yuan Yin and Jia-Rui Zhang and Wei Li and Wen-Li Mi and Yan-Qing Wang and Yu-Qiu Zhang and Jin Yu}, doi = {10.1002/advs.202412556}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412556}, shortjournal = {Adv. Sci.}, title = {Microglia-derived interleukin-6 triggers astrocyte apoptosis in the hippocampus and mediates depression-like behavior}, volume = {12}, year = {2025}, }
• (2025). Temporal and spatial metabolic shifts revealing the transition from ulcerative colitis to colitis-associated colorectal cancer. ADVS, 12(11), 2412551. (www)

  @article{ , abstract = {Patients with ulcerative colitis (UC) have a higher risk of developing colorectal cancer (CRC), however, the metabolic shifts during the UC-to-CRC transition remain elusive. In this study, an AOM-DSS-induced three-stage colitis-associated colorectal cancer (CAC) model is constructed and targeted metabolomics analysis and pathway enrichment are performed, uncovering the metabolic changes in this transition. Spatial metabolic trajectories in the “normal-to-normal adjacent tissue (NAT)-to-tumor” transition, and temporal metabolic trajectories in the “colitis-to-dysplasia-to-carcinoma” transition are identified through K-means clustering of 74 spatially and 77 temporally differential metabolites, respectively. The findings reveal two distinct metabolic profile categories during the inflammation-to-cancer progression: those with consistent changes, either increasing (e.g., kynurenic acid, xanthurenic acid) or decreasing (e.g., long-chain fatty acids, LCFAs), and those enriched at specific disease stages (e.g., serotonin). Further analysis of metabolites with consistent temporal trends identifies eicosapentaenoic acid (EPA) as a key metabolite, potentially exerting anti-inflammatory and anti-cancer effects by inhibiting insulin-like growth factor binding protein 5 (IGFBP5). This study reveals novel metabolic mechanisms underlying the transition from UC to CAC and suggests potential targets to delay the progression.}, archive = {J_ADVS}, author = {Ruiqi Sun and Yuanyuan Zhang and Xian Zhao and Tian Tang and Yuepeng Cao and Liu Yang and Yuan Tian and Zunjian Zhang and Pei Zhang and Fengguo Xu}, doi = {10.1002/advs.202412551}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412551}, shortjournal = {Adv. Sci.}, title = {Temporal and spatial metabolic shifts revealing the transition from ulcerative colitis to colitis-associated colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Omnidirectional 3D printing of PEDOT: PSS aerogels with tunable electromechanical performance: A playground for unconventional stretchable interconnects and thermoelectrics. ADVS, 12(11), 2412491. (www)

  @article{ , archive = {J_ADVS}, author = {Hasan Emre Baysal and Tzu-Yi Yu and Viktor Naenen and Stijn De Smedt and Defne Hiz and Bokai Zhang and Heyi Xia and Isidro Florenciano and Martin Rosenthal and Ruth Cardinaels and Francisco Molina-Lopez}, doi = {10.1002/advs.202412491}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412491}, shortjournal = {Adv. Sci.}, title = {Omnidirectional 3D printing of PEDOT: PSS aerogels with tunable electromechanical performance: A playground for unconventional stretchable interconnects and thermoelectrics}, volume = {12}, year = {2025}, }
• (2025). Flexible synaptic memristors with controlled rigidity in zirconium-oxo clusters for high-precision neuromorphic computing. ADVS, 12(11), 2412289. (www)

  @article{ , abstract = {Flexible memristors are promising candidates for multifunctional neuromorphic computing applications, overcoming the limitations of conventional computing devices. However, unpredictable switching behavior and poor mechanical stability in conventional memristors present significant challenges to achieving device reliability. Here, a reliable and flexible memristor using zirconium-oxo cluster (Zr 6 O 4 OH 4 (OMc) 12 ) as the resistive switching layer is demonstrated. The optimization of the structural rigidity of the hybrid oxo-cluster network by thermal polymerization allows the precise formation of dispersed conductive cluster networks, enhancing the repeatability of the resistive switching with mechanical flexibility. The optimized memristor exhibits endurance of ∼10 4 cycles and stable memory retention performance up to 10 4 s, maintaining a high I ON / I OFF ratio of 10 4 under a bending radius of 2.5 mm. Moreover, the device achieves a pattern recognition accuracy of 97.44%, enabled by highly symmetric analog switching with multilevel conductance states. These results highlight that hybrid metal-oxo clusters can provide novel material design principles for flexible and reliable neuromorphic applications, contributing to the development of artificial neural networks.}, archive = {J_ADVS}, author = {Jae-Hyeok Cho and Suk Yeop Chun and Ga Hye Kim and Panithan Sriboriboon and Sanghee Han and Seung Beom Shin and Jeehoon Kim and San Nam and Yunseok Kim and Yong-Hoon Kim and Jung Ho Yoon and Myung-Gil Kim}, doi = {10.1002/advs.202412289}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412289}, shortjournal = {Adv. Sci.}, title = {Flexible synaptic memristors with controlled rigidity in zirconium-oxo clusters for high-precision neuromorphic computing}, volume = {12}, year = {2025}, }
• (2025). METTL3 potentiates m2 macrophage-driven MMT to aggravate renal allograft fibrosis via the TGF-β1/Smad3 pathway. ADVS, 12(11), 2412123. (www)

  @article{ , abstract = {METTL3, a key enzyme in N6-methyladenosine (m6A) modification, plays a crucial role in the progression of renal fibrosis, particularly in chronic active renal allograft rejection (CAR). This study explored the mechanisms by which METTL3 promotes renal allograft fibrosis, focusing on its role in the macrophage-to-myofibroblast transition (MMT). Using a comprehensive experimental approach, including TGF-β1-induced MMT cell models, METTL3 conditional knockout (METTL3 KO) mice, and renal biopsy samples from patients with CAR, the study investigates the involvement of METTL3/Smad3 axis in driving MMT and renal fibrosis during the episodes of CAR. We found that elevated m6A modification and METTL3 levels strongly correlated with enhanced MMT and increased fibrotic severity. METTL3 knockout (METTL3 KO) significantly increased the m6A modification of Smad3, decreased Smad3 expression, and inhibited M2-driven MMT. Smad3 knockdown with siRNA (siSmad3) further inhibited M2-driven MMT, while Smad3 overexpression rescued the inhibitory effects of METTL3 silencing, restoring M2-driven MMT and fibrotic tissue damage. Additionally, the METTL3 inhibitor STM2457 effectively reversed M2-driven MMT and alleviated fibrotic tissue damage in CAR. These findings highlight that METTL3 enhances M2-driven MMT in renal fibrosis during CAR by promoting the TGF-β1/Smad3 axis, suggesting that METTL3 is a promising therapeutic target for mitigating renal fibrosis in CAR.}, archive = {J_ADVS}, author = {Qinfan Yao and Xiaoxiao Zheng and Xinyi Zhang and Yucheng Wang and Qin Zhou and Junhao Lv and Li Zheng and Jiahua Lan and Wei Chen and Jianghua Chen and Dajin Chen}, doi = {10.1002/advs.202412123}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412123}, shortjournal = {Adv. Sci.}, title = {METTL3 potentiates m2 macrophage-driven MMT to aggravate renal allograft fibrosis via the TGF-β1/Smad3 pathway}, volume = {12}, year = {2025}, }
• (2025). Development of a self-deploying extra-aortic compression device for medium-term hemodynamic stabilization: A feasibility study. ADVS, 12(11), 2412120. (www)

  @article{ , abstract = {Hemodynamic stabilization is crucial in managing acute cardiac events, where compromised blood flow can lead to severe complications and increased mortality. Conditions like decompensated heart failure (HF) and cardiogenic shock require rapid and effective hemodynamic support. Current mechanical assistive devices, such as intra-aortic balloon pumps (IABP) and extracorporeal membrane oxygenation (ECMO), offer temporary stabilization but are limited to short-term use due to risks associated with prolonged blood contact. This research presents a novel proof-of-concept soft robotic device designed with the aim of achieving low-risk, medium-term counterpulsation therapy. The device employs a nature-inspired growing mechanism for potentially minimally invasive deployment around the ascending aorta, coupled with hydraulic artificial muscles for aortic compression. It demonstrated a maximum stroke volume of 16.48 ± 0.21 mL (SD, n = 5), outperforming all other non-pneumatic extra-aortic devices. In addition, in vitro tests with a mock circulation loop (MCL) show a drop in aortic end-diastolic pressure by 6.32 mmHg and enhance coronary flow under mild aortic stenosis, which attenuate the device's assistive effect. These findings highlight the device's strong potential for optimization as a promising solution to improve outcomes for hemodynamically unstable HF patients.}, archive = {J_ADVS}, author = {Adrienne Ji and James Davies and Phuoc Thien Phan and Chi Cong Nguyen and Bibhu Sharma and Kefan Zhu and Emanuele Nicotra and Jingjing Wan and Hoang-Phuong Phan and Christopher Hayward and Nigel H. Lovell and Thanh Nho Do}, doi = {10.1002/advs.202412120}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2412120}, shortjournal = {Adv. Sci.}, title = {Development of a self-deploying extra-aortic compression device for medium-term hemodynamic stabilization: A feasibility study}, volume = {12}, year = {2025}, }
• (2025). Pressure-induced emission enhancement of multi-resonance o-carborane derivatives via Exciton‒Vibration coupling suppression. ADVS, 12(11), 2411765. (www)

  @article{ , abstract = {Polycyclic multiple resonance (MR) molecules reveal narrowband emission, making them very promising emitters for high color purity display. Nevertheless, they still have challenges such as aggregation-induced emission quenching and spectral broadening. Overcoming these obstacles requires an in-depth understanding of the correlations among the alterations in their geometries, packing structures, and molecular vibrations and their corresponding changes in their photoluminescence (PL) properties. Herein, it is demonstrated that high-pressure infrared, UV−visible absorption, and fluorescence spectroscopies can be combined with computational results to elucidate the influence of the subtle structural variations on the exciton‒vibration couplings and their PL properties. An ortho-carborane-decorated MR emitter (BNC) is a piezochromic molecule and exhibits emission enhancement under high pressure. A thorough analysis of the in situ experimental measurements and calculated results reveals that the pressure-induced changes in the exciton binding energy and exciton‒vibration couplings are responsible for the unusual piezochromism. This research provides insights into the structure‒fluorescence relationship and potential for high-pressure techniques to optimize MR materials for advanced organic light-emitting diodes (OLEDs) applications.}, archive = {J_ADVS}, author = {Zening Li and Qing Zhang and Fangxiang Sun and Chunyan Lv and Xinmiao Meng and Yu Hu and Dongqian Xu and Chengjian Li and Lei Li and Kai Wang and Yujian Zhang}, doi = {10.1002/advs.202411765}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2411765}, shortjournal = {Adv. Sci.}, title = {Pressure-induced emission enhancement of multi-resonance o-carborane derivatives via Exciton‒Vibration coupling suppression}, volume = {12}, year = {2025}, }
• (2025). Nonlinear harmonics: A gateway to enhanced image contrast and material discrimination. ADVS, 12(11), 2411556. (www)

  @article{ , abstract = {Recent advancements in atomic force microscopy (AFM) have enabled detailed exploration of materials at the molecular and atomic levels. These developments, however, pose a challenge: the data generated by microscopic and spectroscopic experiments are increasing rapidly in both size and complexity. Extracting meaningful physical insights from these datasets is challenging, particularly for multilayer heterogeneous nanoscale structures. In this paper, an unsupervised approach is presented to enhance AFM image contrast by analyzing the nonlinear response of a cantilever interacting with a material's surface using a wavelet-based AFM. This method simultaneously measures different frequencies and harmonics in a single scan, without the need for additional hardware and exciting multiple cantilevers' eigenmodes. This developed AFM image contrast enhancement (AFM-ICE) approach employs unsupervised learning, image processing, and image fusion techniques. The method is applied to interpret complex multilayer structures consist of defects, deposited nanoparticles and heterogeneities. Its substantial capability is demonstrated to improve image contrast and differentiate between various components. This methodology can pave the way for rapid and precise determination of material properties with enhanced resolution.}, archive = {J_ADVS}, author = {Pardis Biglarbeigi and Gourav Bhattacharya and Dewar Finlay and Amir Farokh Payam}, doi = {10.1002/advs.202411556}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2411556}, shortjournal = {Adv. Sci.}, title = {Nonlinear harmonics: A gateway to enhanced image contrast and material discrimination}, volume = {12}, year = {2025}, }
• (2025). Controlled inflammation drives neutrophil-mediated precision drug delivery in heterogeneous tumors. ADVS, 12(11), 2411307. (www)

  @article{ , abstract = {Tumor heterogeneity remains a formidable obstacle in targeted cancer therapy, often leading to suboptimal treatment outcomes. This study presents an innovative approach that harnesses controlled inflammation to guide neutrophil-mediated drug delivery, effectively overcoming the limitations imposed by tumor heterogeneity. By inducing localized inflammation within tumors using lipopolysaccharide, it significantly amplify the recruitment of drug-laden neutrophils to tumor sites, irrespective of specific tumor markers. This strategy not only enhances targeted drug delivery but also triggers the release of neutrophil extracellular traps, further potentiating the anti-tumor effect. Crucially, this study demonstrates that potential systemic inflammatory responses can be effectively mitigated through neutrophil transfusion, ensuring the safety and clinical viability of this approach. In a murine breast cancer model, the method significantly impedes tumor growth compared to conventional treatments. This work offers a versatile strategy for precise drug delivery across diverse tumor types. The findings pave the way for more effective and broadly applicable cancer treatments, potentially addressing the long-standing challenge of tumor heterogeneity.}, archive = {J_ADVS}, author = {Yunfei Guo and Yiming Li and Jianmin Li and Haoran Cai and Kangkang Liu and Dengyi Duan and Wenyi Zhang and Gang Han and Yang Zhao}, doi = {10.1002/advs.202411307}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2411307}, shortjournal = {Adv. Sci.}, title = {Controlled inflammation drives neutrophil-mediated precision drug delivery in heterogeneous tumors}, volume = {12}, year = {2025}, }
• (2025). Gaudichaudione h enhances the sensitivity of hepatocellular carcinoma cells to disulfidptosis via regulating NRF2-SLC7A11 signaling pathway. ADVS, 12(11), 2411131. (www)

  @article{ , abstract = {Gaudichaudione H (GH) is a naturally occurring small molecular compound derived from Garcinia oligantha Merr . (Clusiaceae), but the full pharmacological functions remain unclear. Herein, the potential of GH in disulfidptosis regulation, a novel form of programmed cell death induced by disulfide stress is explored. The omics results indicated that NRF2 signaling could be significantly activated by GH. The potential targets are associated with hepatocarcinogenesis and cell death. Moreover, both glutathione (GSH) metabolism and NADP + -NADPH metabolism are affected by GH, indicating the potential in disulfidptosis regulation. It is also observed that GH enhanced the sensitivity of hepatocellular carcinoma (HCC) cells to disulfidptosis, which is dependent on the activation of NRF2-SLC7A11 pathway. GH significantly increased the levels of NRF2 and promoted the transcription of NRF2 target gene, SLC7A11, through autophagy-mediated non-canonical mechanism. Under the condition of glucose starvation, GH-induced upregulation of SLC7A11 aggravated uptake of cysteine, disturbance of GSH synthesis, depletion of NADPH, and accumulation of disulfide molecules, ultimately leading to the formation of disulfide bonds between different cytoskeleton proteins and disulfidptosis eventually. Collectively, the findings underscore the potential role of GH in promoting cancer cell disulfidptosis, thereby offering a promising avenue for the treatment of drug-resistant HCC in clinical settings.}, archive = {J_ADVS}, author = {Mengjiao Shi and Xinyan Li and Ying Guo and Yinggang Zhang and Jiayi Xu and Liangwen Yan and Rongrong Liu and Hong Wang and Shenkang Tang and Yaping Zhao and Zongfang Li and Yetong Feng and Dongmei Ren and Pengfei Liu}, doi = {10.1002/advs.202411131}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2411131}, shortjournal = {Adv. Sci.}, title = {Gaudichaudione h enhances the sensitivity of hepatocellular carcinoma cells to disulfidptosis via regulating NRF2-SLC7A11 signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Turning waste into treasure: Functionalized biomass-derived carbon dots for superselective visualization and eradication of gram-positive bacteria. ADVS, 12(11), 2411084. (www)

  @article{ , abstract = {Gram-positive bacteria pose significant threats to human health, necessitating the development of targeted bacterial detection and eradication strategies. Nevertheless, current approaches often suffer from poor targeting specificity. Herein, the study utilizes purple rice lixivium to synthesize biomass carbon dots (termed BCDs) with wheat germ agglutinin-like residues for precisely targeting Gram-positive bacteria. Subsequently, fluorescein isothiocyanate (FITC) molecules are grafted onto BCDs to yield FITC-labeled BCDs (termed CDFs), which can selectively and rapidly (≤5 min) stain bacterial cell wall and particularly target the peptidoglycan component. Strikingly, CDFs achieve superselective visualization of Gram-positive bacteria even in the presence of mammalian cells and Gram-negative bacteria. Furthermore, protoporphyrin (PpIX) molecules are conjugated onto BCDs to yield PpIX-modified BCDs (termed CDPs), which can induce bacterial aggregation and in situ generate singlet oxygen for realizing enhanced antibacterial photodynamic therapy (PDT). At the minimum bactericidal concentration of CDPs (PpIX: 5 µg mL −1 ), CDP-mediated PDT disrupts bacterial structure and metabolism pathways, thereby affecting bacterial interactions to eradicate biofilms. Importantly, CDP-mediated PDT efficiently modulates antiinflammatory responses to promote wound healing in the bacteria-infected mice. This study underscores the significance of harnessing renewable and cost-effective biomass resources for preparing Gram-positive bacteria-targeting theranostic agents, which may find potential clinical applications in the future.}, archive = {J_ADVS}, author = {Ke-Fei Xu and Zihao Wang and Macheng Cui and Yuhan Jiang and Chengcheng Li and Zi-Xi Wang and Ling-Yi Li and Chenyang Jia and Lijie Zhang and Fu-Gen Wu}, doi = {10.1002/advs.202411084}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2411084}, shortjournal = {Adv. Sci.}, title = {Turning waste into treasure: Functionalized biomass-derived carbon dots for superselective visualization and eradication of gram-positive bacteria}, volume = {12}, year = {2025}, }
• (2025). Organizational principles of the primate cerebral cortex at the single-cell level. ADVS, 12(11), 2411041. (www)

  @article{ , abstract = {The primate cerebral cortex, the major organ for cognition, consists of an immense number of neurons. However, the organizational principles governing these neurons remain unclear. By accessing the single-cell spatial transcriptome of over 25 million neuron cells across the entire macaque cortex, it is discovered that the distribution of neurons within cortical layers is highly non-random. Strikingly, over three-quarters of these neurons are located in distinct neuronal clusters. Within these clusters, different cell types tend to collaborate rather than function independently. Typically, excitatory neuron clusters mainly consist of excitatory-excitatory combinations, while inhibitory clusters primarily contain excitatory-inhibitory combinations. Both cluster types have roughly equal numbers of neurons in each layer. Importantly, most excitatory and inhibitory neuron clusters form spatial partnerships, indicating a balanced local neuronal network and correlating with specific functional regions. These organizational principles are conserved across mouse cortical regions. These findings suggest that different brain regions of the cortex may exhibit similar mechanisms at the neuronal population level.}, archive = {J_ADVS}, author = {Renrui Chen and Pengxing Nie and Liangxiao Ma and Guang-Zhong Wang}, doi = {10.1002/advs.202411041}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2411041}, shortjournal = {Adv. Sci.}, title = {Organizational principles of the primate cerebral cortex at the single-cell level}, volume = {12}, year = {2025}, }
• (2025). Direct observation of substantial phonon nonequilibrium near nanoscale hotspots in gallium nitride. ADVS, 12(11), 2411040. (www)

  @article{ , abstract = {Phonon modal nonequilibrium is believed to widely exist around nanoscale hotspots, which can significantly affect the performance of nano-electronic and optoelectronic devices. However, such a phenomenon has not been explicitly observed in 3D device semiconductors at the nanoscale. Here, by employing a tip-enhanced Raman thermal measurement approach, substantial phonon nonequilibrium in gallium nitride near sub-10 nm laser-excited hotspots is directly revealed for the first time. As further evidence, quantitative agreements between measurements and accurate first-principles-based phonon Boltzmann transport equation calculations are obtained. The large nonequilibrium is attributed to the strong Fröhlich coupling of electrons with longitudinal optical phonons and the large acoustic-optical phonon frequency gap in gallium nitride, which is further demonstrated in other common III-V semiconductors. This work establishes a viable approach for understanding nanoscale nonequilibrium phonon transport and can potentially benefit the future modulation of hot carrier dynamics.}, archive = {J_ADVS}, author = {Jiaxuan Xu and Xiaona Huang and Yufei Sheng and Qiangsheng Sun and Hongkai Zhang and Hua Bao and Yanan Yue}, doi = {10.1002/advs.202411040}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2411040}, shortjournal = {Adv. Sci.}, title = {Direct observation of substantial phonon nonequilibrium near nanoscale hotspots in gallium nitride}, volume = {12}, year = {2025}, }
• (2025). Optimal neutron spectrum database for in-reactor 238Pu production. ADVS, 12(11), 2410995. (www)

  @article{ , abstract = {Plutonium-238 ( 238 Pu) is a scarce heat-source radioisotope used in nuclear batteries, which is produced by in-reactor irradiation of Americium-241 ( 241 Am) or Neptunium-237 ( 237 Np). Optimizing the neutron spectrum can improve the production efficiency of 238 Pu, but currently, it is still a lack of knowledge about the optimal neutron spectrum for 238 Pu production. Genetic algorithms and burnup algorithms are combined to identify optimal neutron spectra for 238 Pu production under various irradiation times and flux levels, and build an optimal neutron spectrum database, which answers the questions “What is the optimal neutron spectrum for 238 Pu production?” and “What is the maximum efficiency for 238 Pu production” once and for all. This database can be referred to for determining the optimal neutron spectrum, guiding the neutron spectrum regulation process to improve the yield of 238 Pu. Moreover, these results find that the production method of in-reactor irradiation 237 Np not only has a higher yield but also achieves a higher purity of 238 Pu than that of in-reactor irradiation 241 Am, which conflicts with the traditional experiences, providing with previously unknown insights and helping break through the efficiency limit of traditional methods, maximizing 238 Pu production.}, archive = {J_ADVS}, author = {Qingquan Pan and Xiaojing Liu and Yun Cai}, doi = {10.1002/advs.202410995}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410995}, shortjournal = {Adv. Sci.}, title = {Optimal neutron spectrum database for in-reactor 238Pu production}, volume = {12}, year = {2025}, }
• (2025). Plant diversity reduces the risk of antibiotic resistance genes in agroecosystems. ADVS, 12(11), 2410990. (www)

  @article{ , abstract = {Despite advances in dispersal mechanisms and risk assessment of antibiotic resistance genes (ARGs), how plants influence ARG contamination in agricultural soils remains underexplored. Here, the impacts of plant species and diversity on ARGs and mobile genetic elements (MGEs) in three agricultural soils are comprehensively investigated in a pot experiment. The results indicate that increased plant diversity reduces ARGs and MGEs abundance by 19.2%–51.2%, whereas plant species exhibit inconsistent and soil-dependent effects. Potential bacterial hosts harboring abundant ARGs have greater relative abundance than nonhosts, and both their richness and cumulative relative abundance are reduced by plant diversity. Notably, hosts inhibited by plant diversity present a greater relative abundance than the other hosts. The enriched compounds in root exudates due to plant diversity play a more important role in the metabolic network and contribute to rebalancing of the abundance of potential hosts and nonhosts. An independent test using pure organics reveals that higher resource diversity, resulting from increased plant diversity, reduces the relative abundance and mobility of abundant and high-risk ARGs. This study highlights the resource-mediated mitigation of the risks posed by ARG contamination and indicates that ensuring plant and resource diversity is a promising strategy for controlling ARGs in agroecosystems.}, archive = {J_ADVS}, author = {Shu Li and Xing Zhou and Liangliang Liu and Zhe Su and Jun Zhao and Jinbo Zhang and Zucong Cai and Josep Peñuelas and Xinqi Huang}, doi = {10.1002/advs.202410990}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410990}, shortjournal = {Adv. Sci.}, title = {Plant diversity reduces the risk of antibiotic resistance genes in agroecosystems}, volume = {12}, year = {2025}, }
• (2025). Tau pathology drives disease-associated astrocyte reactivity in salt-induced neurodegeneration. ADVS, 12(11), 2410799. (www)

  @article{ , abstract = {Dietary high salt intake is increasingly recognized as a risk factor for cognitive decline and dementia, including Alzheimer’s disease (AD). Recent studies have identified a population of disease-associated astrocytes (DAA)-like astrocytes closely linked to amyloid deposition and tau pathology in an AD mouse model. However, the presence and role of these astrocytes in high-salt diet (HSD) models remain unexplored. In this study, it is demonstrated that HSD significantly induces enhanced reactivity of DAA-like astrocytes in the hippocampal CA3 region of mice, with this reactivity being critically dependent on neuronal tau pathology. Neuronal tau pathology activates adenosine A1R signaling, exacerbating tau pathology by inhibiting the Cers1 pathway, which sustains astrocyte reactivity. Additionally, neurons burdened with tau pathology promote astrocyte reactivity via releasing Proteins Associated with Promoting DAA-like Astrocyte Reactivity (PAPD), with Lcn2 playing a pivotal role. Knockout of Lcn2 or its receptor 24p3R significantly mitigates HSD-induced DAA reactivity and neuroinflammation. These findings suggest a vicious cycle between tau pathology and A1R signaling, driving DAA-like astrocyte reactivity. Targeting the Tau-A1R axis may provide a novel therapeutic strategy for reducing HSD-induced neuroinflammation and cognitive deficits.}, archive = {J_ADVS}, author = {Tong-Yu Rui and He-Zhou Huang and Kai Zheng and Hong-Wei Fan and Juan Zhang and Zi-Yuan Guo and Heng-Ye Man and Nadezhda Brazhe and Alexey Semyanov and You-Ming Lu and Dan Liu and Ling-Qiang Zhu}, doi = {10.1002/advs.202410799}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410799}, shortjournal = {Adv. Sci.}, title = {Tau pathology drives disease-associated astrocyte reactivity in salt-induced neurodegeneration}, volume = {12}, year = {2025}, }
• (2025). Targeting p21-positive senescent chondrocytes via IL-6R/JAK2 inhibition to alleviate osteoarthritis. ADVS, 12(11), 2410795. (www)

  @article{ , abstract = {Osteoarthritis (OA) is an age-related degenerative joint disease, prominently influenced by the pro-inflammatory cytokine interleukin-6 (IL-6). Although elevated IL-6 levels in joint fluid are well-documented, the uneven cartilage degeneration observed in knee OA patients suggests additional underlying mechanisms. This study investigates the role of interleukin-6 receptor (IL-6R) in mediating IL-6 signaling and its contribution to OA progression. Here, significantly elevated IL-6R expression is identified in degenerated cartilage of OA patients. Further, in vivo experiments reveal that intra-articular injection of recombinant IL-6R protein or activation of gp130 (Y757F mutation) accelerates OA progression. Conversely, knockout of IL-6R or JAK2, as well as treatment with a JAK inhibitor, alleviates OA symptoms. Mechanistically, chondrocytes derived from degenerative cartilage exhibit impaired nuclear localization of SOX9, a key regulator of cartilage homeostasis. JAK inhibition stabilizes SIRT1, reduces SOX9 acetylation, and thereby facilitates SOX9 nuclear localization, promoting cartilage repair. Additionally, the JAK inhibitor-induced apoptosis in p21-positive senescent cells, and their targeted clearance successfully alleviates OA in p21-3MR mice. In conclusion, these findings reveal a novel mechanism by which inhibiting the IL-6R/JAK2 pathway can alleviate OA. Furthermore, this study proposes targeting p21-positive senescent cells as a new therapeutic strategy for OA.}, archive = {J_ADVS}, author = {Xiang Zhao and Jieming Lin and Feng Liu and Yu Zhang and Bo Shi and Chunhui Ma and Ziqi Wang and Song Xue and Qingrong Xu and Hongda Shao and Jingxing Yang and Yanzheng Gao}, doi = {10.1002/advs.202410795}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410795}, shortjournal = {Adv. Sci.}, title = {Targeting p21-positive senescent chondrocytes via IL-6R/JAK2 inhibition to alleviate osteoarthritis}, volume = {12}, year = {2025}, }
• (2025). Subcellular cavitation bubbles induce cellular mechanolysis and collective wound healing in ultrasound-inflicted cell ablation. ADVS, 12(11), 2410760. (www)

  @article{ , abstract = {Focused ultrasound (FUS) has been widely adopted in medical and life science researches. Although various physical and biological effects of FUS have been well-documented, there is still a lack of understanding and direct evidence on the biological mechanism of therapeutic cell ablation caused by high-intensity ultrasound (HIFU) and the subsequent wound healing responses. This study develops an enclosed cell culture device that synergistically combines non-invasive FUS stimulation and real-time, on-the-fly live-cell imaging, providing an in vitro platform to explore short and long-term biological effects of ultrasound. The process, mechanism, and wound healing response of cell ablation induced by HIFU are elucidated, revealing a unique mechanism, termed ultrasound-inflicted cellular mechanolysis, that is mediated by growing subcellular cavitation air bubbles under confined contact with cells. This provides a previously unappreciated mechanism for understanding the biomechanical principles of ultrasound-based ablative therapy. A post-ablation phantom layer is also revealed that serves as a guiding cue for collective cell migration during wound healing, thereby providing a biomimetic model for studying wound healing after HIFU-inflicted damage. Together, this study provides theoretical and technological basis for advancing the understanding of the biological effects of ultrasound-based ablative therapy and inspiring clinically relevant applications in the future.}, archive = {J_ADVS}, author = {Ziyue Bai and Zaimeng Li and Yue Shao}, doi = {10.1002/advs.202410760}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410760}, shortjournal = {Adv. Sci.}, title = {Subcellular cavitation bubbles induce cellular mechanolysis and collective wound healing in ultrasound-inflicted cell ablation}, volume = {12}, year = {2025}, }
• (2025). Peptide-bound aflibercept eye drops for treatment of neovascular age-related macular degeneration in nonhuman primates. ADVS, 12(11), 2410744. (www)

  @article{ , abstract = {The advent of biomacromolecules antagonizing vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular age-related macular degeneration (nAMD). However, frequent intravitreal injections of these biomacromolecules impose an enormous burden on patients and create a massive workload for healthcare providers. This causes patients to abandon therapy, ultimately leading to progressive and irreversible vision loss. In order to address this unmet clinical need, a noninvasive treatment for nAMD is developed. An optimized cell-penetrating peptide derivative, bxy Penetratin (bxyWP), is used to non-covalently complex with the anti-VEGF protein aflibercept (AFL) via reversible hydrophobic interaction. The interaction is crucial for AFL delivery, neither impairing the affinity of AFL to pathological VEGF, nor being interfered by endogenous proteins in tear fluids. AFL/bxyWP eye drops exhibit prolonged retention on the eye and excellent absorption into the posterior ocular segment following topical administration, with significant drug distribution to the retina and choroid. In a laser-induced choroidal neovascularization model on cynomolgus monkeys, AFL/bxyWP eye drops efficiently reduce lesion size and leakage comparable to conventional intravitreal injection of AFL. These results suggest that AFL/bxyWP eye drops are feasible self-administered treatment for neovascular retinal diseases and potentially become a substitute for intravitreal injections.}, archive = {J_ADVS}, author = {Xingyan Fan and Kuan Jiang and Yongqian Zhao and Benjamin TK Lee and Feiyang Geng and Marten E Brelen and Weiyue Lu and Gang Wei}, doi = {10.1002/advs.202410744}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410744}, shortjournal = {Adv. Sci.}, title = {Peptide-bound aflibercept eye drops for treatment of neovascular age-related macular degeneration in nonhuman primates}, volume = {12}, year = {2025}, }
• (2025). Large electromechanical response and field-induced shape memory effect in ferroelectric ceramics. ADVS, 12(11), 2410580. (www)

  @article{ , abstract = {Electric-field-induced shape memory effect has potential applications in electromechanical actuator. Here, this study proposes the a phase structure design routine in (1- x )(75Na 0.5 Bi 0.5 TiO 3 -25SrTiO 3 )- x PbTiO 3 ceramics to obtain large electromechanical response and shape memory effect. It is found that the shape memory effect is closely related to the bending deformation induced by asymmetric polarization between positive and negative electrodes, which is resulted from the reductions of Bi 3+ and Pb 2+ because of electron injection from negative electrode. In addition, the content of ferroelectric phase with P4 mm structure and c/a ratio increase with PbTiO 3 content increasing, and the coercive field of the ceramics is also enhanced by the PbTiO 3 addition, Combing the crystal structure and chemical composition, the field-induced deformation achieves 2.77% and shape memory effect is 1.75% at 80kV cm −1 and 0.1 Hz in the ceramic with the content of PbTiO 3 is 40%.}, archive = {J_ADVS}, author = {Menglu Li and Weili Li and Wenping Cao and Nuo Xu and Wenqi Li and Weidong Fei}, doi = {10.1002/advs.202410580}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410580}, shortjournal = {Adv. Sci.}, title = {Large electromechanical response and field-induced shape memory effect in ferroelectric ceramics}, volume = {12}, year = {2025}, }
• (2025). Billion-scale expansion of functional hiPSC-derived cardiomyocytes in bioreactors through oxygen control and continuous wnt activation. ADVS, 12(11), 2410510. (www)

  @article{ , abstract = {Generation of upscaled quantities of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM), for therapeutic or testing applications, is both expensive and time-consuming. Herein, a scalable bioprocess for hiPSC-CM expansion in stirred-tank bioreactors (STB) is developed. By combining the continuous activation of the Wnt pathway, through perfusion of CHIR99021, within a mild hypoxia environment, the expansion of hiPSC-CM as aggregates is maximized, reaching 4 billion of pure hiPSC-CM in 2L STB. In particular, the importance of i) controlling the dissolved oxygen at 10% O 2 to reduce reactive oxygen species production and upregulate genes involved in cell proliferation, resulting in higher expansion rates (tenfold) compared to normoxic conditions, and ii) maintaining constant power input per volume as a scale-up criteria is demonstrated. After expansion, hiPSC-CM further mature in culture, revealing more mature transcriptional signatures, higher sarcomere alignment and improved calcium handling. This new bioprocess opens the door to time- and cost-effective generation of hiPSC-CM.}, archive = {J_ADVS}, author = {Pedro Vicente and Lara R. Inocêncio and Asier Ullate-Agote and Ana F. Louro and João Jacinto and Beatriz Gamelas and Olalla Iglesias-García and Patxi San Martin-Uriz and Paula Aguirre-Ruiz and Gonzalo R. Ríos-Muñoz and María Eugenia Fernández-Santos and Alain van Mil and Joost P. G. Sluijter and Felipe Prósper and Manuel M Mazo Vega and Paula M. Alves and Margarida Serra}, doi = {10.1002/advs.202410510}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410510}, shortjournal = {Adv. Sci.}, title = {Billion-scale expansion of functional hiPSC-derived cardiomyocytes in bioreactors through oxygen control and continuous wnt activation}, volume = {12}, year = {2025}, }
• (2025). Top–Down strategy enabling elastic wood nanocarbon sponges with wrinkled multilayer structure and high compressive strength for high-performance compressible supercapacitors. ADVS, 12(11), 2410397. (www)

  @article{ , abstract = {3D porous carbon electrodes have attracted significant attention for advancing compressible supercapacitors (SCs) in flexible electronics. The micro- and nanoscale architecture critically influences the mechanical and electrochemical performance of these electrodes. However, achieving a balance between high compressive strength, electrochemical stability, and cost-effective sustainable production remains challenging. Here, a superelastic wood nanocarbon sponge (WNCS) with a wrinkled multilayer structure is developed via a facile “top–down” design on natural wood. These unique wrinkled nanolayers effectively alleviate stress concentration through elastic deformation, resulting in a high compressive strength of 580.6 kPa at 70% reversible strain. The significantly increased specific surface area, coupled with abundant micro-mesopores and highly graphitized nanocarbon, promotes rapid ion/electron transport, enabling the WNCS to achieve an ultrahigh capacitance of 4.21 F cm −2 at 1 mA cm −2 , along with excellent cyclic stability and rate capability. Furthermore, an asymmetric supercapacitor (ASC) using a WNCS anode and a NiCo-layered double hydroxide cathode retains 71.8% of its initial capacitance after 1000 compression cycles and withstands stress up to 1.03 MPa without capacitance degradation. This sustainable, cost-effective WNCS shows great promise for flexible, compressible, and wearable electrochemical energy systems.}, archive = {J_ADVS}, author = {Song Wei and Caichao Wan and Xingong Li and Shanshan Jia and Ruwei Chen and Guanjie He and Yiqiang Wu}, doi = {10.1002/advs.202410397}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410397}, shortjournal = {Adv. Sci.}, title = {Top–Down strategy enabling elastic wood nanocarbon sponges with wrinkled multilayer structure and high compressive strength for high-performance compressible supercapacitors}, volume = {12}, year = {2025}, }
• (2025). A fuel cell power supply system equipped with artificial gill membranes for underwater applications. ADVS, 12(11), 2410358. (www)

  @article{ , abstract = {This work proposes a fuel cell power supply system for underwater applications (e.g., autonomous underwater vehicles), where artificial gills, based on a polymer membrane, harvest the required oxygen from the ambient water. In this system, a circulating air-flow continuously supplies a proton exchange membrane fuel cell with oxygen, which is replenished using a polymer membrane. The membrane serves as the interface between the circulating air-flow and the ambient water, preventing water flux while allowing an oxygen flux across the membrane, driven by a partial oxygen pressure gradient. To demonstrate the feasibility of this concept, a prototype system was built based on guidelines derived from a mathematical model that was developed to describe the oxygen transfer process. A computational fluid dynamics model is developed and validated against the measurements from the prototype, resulting in a digital twin. The analysis indicates that the proposed power supply system has the potential to be superior to any battery-based solution currently available.}, archive = {J_ADVS}, author = {Lucas Merckelbach and Prokopios Georgopanos}, doi = {10.1002/advs.202410358}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410358}, shortjournal = {Adv. Sci.}, title = {A fuel cell power supply system equipped with artificial gill membranes for underwater applications}, volume = {12}, year = {2025}, }
• (2025). Ammonia synthesis over an iron catalyst with an inverse structure. ADVS, 12(11), 2410313. (www)

  @article{ , abstract = {Achieving a substantial increase in the ammonia productivity of the Haber-Bosch (HB) process at low temperatures has been a significant challenge for over 100 years. However, the iron catalyst designed over 100 years ago remains at the forefront of this process because it is difficult to exceed the industrial iron catalyst in terms of the ammonia synthesis rate/catalyst volume that determines ammonia productivity in a reactor. Here, a new catalyst with an inverse structure of a supported metal catalyst that consists of metallic iron particles loaded with an aluminum hydride species is reported. The iron catalyst is readily prepared from an α-Fe 2 O 3 precursor and ammonia could be synthesized at more than twice the ammonia synthesis rate/catalyst volume of the conventional industrial iron catalyst, even though the specific surface area of the former is only half that of the latter. In addition, ammonia synthesis over the catalyst is observed with a small apparent activation energy at 50 °C. Mechanistic studies suggested that an increase in the active sites with strong electron-donating capability on the iron catalyst significantly increased the ammonia synthesis rate/catalyst surface area, which resulted in high catalytic activity/catalyst volume.}, archive = {J_ADVS}, author = {Masashi Hattori and Kento Miyashita and Yuki Nagasawa and Ryo Suzuki and Michikazu Hara}, doi = {10.1002/advs.202410313}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410313}, shortjournal = {Adv. Sci.}, title = {Ammonia synthesis over an iron catalyst with an inverse structure}, volume = {12}, year = {2025}, }
• (2025). Micro-scale topography triggers dynamic 3D nuclear deformations. ADVS, 12(11), 2410052. (www)

  @article{ , abstract = {Navigating complex extracellular environments requires extensive deformation of cells and their nuclei. Most in vitro systems used to study nuclear deformations impose whole-cell confinement that mimics the physical crowding experienced by cells during 3D migration through tissues. Such systems, however, do not reproduce the types of nuclear deformations expected to occur in cells that line tissues such as endothelial or epithelial cells whose physical confinement stems principally from the topography of their underlying basement membrane. Here, it is shown that endothelial cells and myoblasts cultured on microgroove substrates that mimic the anisotropic topography of the basement membrane exhibit large-scale 3D nuclear deformations, with partial to complete nuclear penetration into the microgrooves. These deformations do not lead to significant DNA damage and are dynamic with nuclei cyclically entering and exiting the microgrooves. Atomic force microscopy measurements show that these deformation cycles are accompanied by transient changes in perinuclear stiffness. Interestingly, nuclear penetration into the grooves is driven principally by cell-substrate adhesion stresses, with a limited need for cytoskeleton-associated forces. Finally, it is demonstrated that myoblasts from laminopathy patients exhibit abnormal nuclear deformations on microgrooves, raising the possibility of using microgroove substrates as a novel functional diagnostic platform for pathologies that involve abnormal nuclear mechanics.}, archive = {J_ADVS}, author = {Claire Leclech and Giulia Cardillo and Bettina Roellinger and Xingjian Zhang and Joni Frederick and Kamel Mamchaoui and Catherine Coirault and Abdul I. Barakat}, doi = {10.1002/advs.202410052}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2410052}, shortjournal = {Adv. Sci.}, title = {Micro-scale topography triggers dynamic 3D nuclear deformations}, volume = {12}, year = {2025}, }
• (2025). Endothelial TRIM35-regulated MMP10 release exacerbates calcification of vascular grafts. ADVS, 12(11), 2409641. (www)

  @article{ , abstract = {Vascular calcification is a highly regulated process in cardiovascular disease (CVD) and is strongly correlated with morbidity and mortality, especially in the adverse stage of vascular remodeling after coronary artery bypass graft surgery (CABG). However, the pathogenesis of vascular graft calcification, particularly the role of endothelial-smooth muscle cell interaction, is still unclear. To test how ECs interact with SMCs in artery grafts, single-cell analysis of wild-type mice is first performed using an arterial isograft mouse model and found robust cytokine-mediated signaling pathway activation and SMC proliferation, together with upregulated endothelial tripartite motif 35 (TRIM35) expression. Unexpectedly, severe SMC calcification in artery grafts is found in TRIM35 conditional endothelial knockout (cKO) mice. Calcified medium (comprising calcium chloride and beta-glycerophosphate)-induced calcium deposition in vitro is also found in SMCs cocultured with TRIM35 knockout endothelium. This extraordinary phenomenon is further confirmed to be induced by increased MMP10 secretion. Mechanistically, endothelial TRIM35 inhibits MMP10 expression and secretion by promoting K63-linked ubiquitination of RelB and maintaining its nuclear localization, consequently inhibiting nuclear transcription of MMP10 through the noncanonical NF-κB signaling pathway. Targeting MMP10 in situ in arterial isografts can effectively alleviate vascular calcification caused by conditional endothelial TRIM35 knockout. These findings demonstrated that TRIM35 inhibited vascular calcification during arterial isograft remodeling, a process that is driven by the aberrant secretion of endothelial MMP10. Targeting MMP10 pathway may be a potential therapeutic strategy for vascular calcification in vessel grafts.}, archive = {J_ADVS}, author = {Yiming Leng and Wei Wang and Jun Lu and Jingyuan Chen and Xuliang Chen and Yalan Li and Jie Wang and Yuanyuan Liu and Qian Tan and Wenjing Yang and Youxiang Jiang and Peiyuan Huang and Jingjing Cai and Hong Yuan and Liang Weng and Qingbo Xu and Yao Lu}, doi = {10.1002/advs.202409641}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2409641}, shortjournal = {Adv. Sci.}, title = {Endothelial TRIM35-regulated MMP10 release exacerbates calcification of vascular grafts}, volume = {12}, year = {2025}, }
• (2025). Programmable stapling peptide based on sulfonium as universal vaccine adjuvants for multiple types of vaccines. ADVS, 12(11), 2409567. (www)

  @article{ , abstract = {Adjuvants are non-specific immune enhancers commonly used to improve the responsiveness and persistence of the immune system toward antigens. However, due to the undefined chemical structure, toxicity, non-biodegradability, and lack of design technology in many existing adjuvants, it remains difficult to achieve substantive breakthroughs in the adjuvant research field. Here, a novel adjuvant development strategy based on stapling peptides is reported to overcome this challenge. The nano-vaccine incorporating peptide adjuvant and recombinant HBsAg protein not only induced strong antibody titers that are equivalent to aluminum adjuvanted vaccines but also simultaneously activated T-cell immune response. Similar results are also observed in herpes zoster vaccine and more complex influenza vaccine. The mechanism analysis demonstrates that antigen is efficiently carried into antigen-presenting cells (APCs) by peptide, further promoting the secretion of cytokines and activation of APCs. In addition, by redesigning the adjuvant, it is found that the sulfonium centers, rather than the sequence of peptide played an important role in immune activation. This discovery may provide a new paradigm for the rational design of peptide-based adjuvants. In brief, this study demonstrates that stapling peptides with sulfonium centers can provide a well-defined, programmable, biocompatible, and effective adjuvant for multiple types of vaccines.}, archive = {J_ADVS}, author = {Yaping Zhang and Chenshan Lian and Wenlong Lai and Leying Jiang and Yun Xing and Huiting Liang and Jin Li and Xinming Zhang and Jianhui Gan and Zigang Li and Feng Yin}, doi = {10.1002/advs.202409567}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2409567}, shortjournal = {Adv. Sci.}, title = {Programmable stapling peptide based on sulfonium as universal vaccine adjuvants for multiple types of vaccines}, volume = {12}, year = {2025}, }
• (2025). Elevated SPARC disrupts the intestinal barrier integrity in crohn's disease by interacting with OTUD4 and activating the MYD88/NF-κB pathway. ADVS, 12(11), 2409419. (www)

  @article{ , abstract = {Disruption of the intestinal epithelial barrier results in increased permeability and is a key factor in the onset and progression of Crohn's disease (CD). The protein SPARC is primarily involved in cell interaction and migration, but its specific role in the intestinal epithelial barrier remains unclear. This study demonstrates that SPARC is significantly overexpressed in both CD patients and murine models of colitis. Furthermore, mice deficient in SPARC exhibits resistance to chemically induced colitis, a phenomenon associated with the modulation of barrier-associated proteins. Mechanistically, it is elucidated that SPARC competitively binds to OTUD4 in conjunction with MYD88, facilitating the translocation of p65 from the cytoplasm to the nucleus and subsequent activation of the p65-MLCK/MLC2 pathway, thereby compromising barrier integrity. Additionally, it is identified that the elevated expression of SPARC in CD is regulated via the METTL3-YTHDF1 axis. These findings indicate that SPARC levels are elevated in patients with CD and in colitis-induced mice, leading to intestinal barrier damage through direct interaction with OTUD4 and subsequent activation of the MYD88/p65/MLCK/MLC2 signaling pathway. Consequently, targeting SPARC or the OTUD4/MYD88/p65/MLCK/MLC2 axis may offer novel insights into the molecular mechanisms underlying CD and represent a potential therapeutic strategy.}, archive = {J_ADVS}, author = {Jiayu Wang and Yuxin He and Xingchao Zhu and Jinghan Zhu and Zilin Deng and Huan Zhang and Yanjun Chen and Guangbo Zhang and Tongguo Shi and Weichang Chen}, doi = {10.1002/advs.202409419}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2409419}, shortjournal = {Adv. Sci.}, title = {Elevated SPARC disrupts the intestinal barrier integrity in crohn's disease by interacting with OTUD4 and activating the MYD88/NF-κB pathway}, volume = {12}, year = {2025}, }
• (2025). An insect effector mimics its host immune regulator to undermine plant immunity. ADVS, 12(11), 2409186. (www)

  @article{ , abstract = {Plants activate defense machinery when infested by herbivorous insects but avoid such costs in the absence of herbivory. However, the key signaling pathway regulators underlying such flexibility and the mechanisms that insects exploit these components to disarm plant defense systems remain elusive. Here, it is reported that immune repressor 14-3-3e in rice Oryza sativa (OsGF14e) regulates immune homeostasis. Infestation with brown planthopper (BPH) Nilaparvata lugens decreased OsGF14e expression; however, the level of downregulation is limited both by the short duration and the specific feeding location. OsGF14e interacts with Enhanced Disease Resistance 1-like (OsEDR1l), a Raf-like MAP kinase kinase kinase (MAPKKK), and repressed jasmonic acid, jasmonic acid-isoleucine, and H 2 O 2 accumulation by enhancing OsEDR1l abundance and signaling ability. OsGF14e and OsEDR1l overexpression renders rice susceptible to BPH, whereas their knockout increases plant resistance but compromises rice growth and grain yield. Intriguingly, BPH 14-3-3e protein (Nl14) that shares high sequence homology and structural similarity with OsGF14e is identified from BPH saliva and egg-associated secretions. Mediated through BPH feeding and oviposition, Nl14, similar to OsGF14e, interacts with OsEDR1l and triggers the OsEDR1l signaling, thereby suppressing plant defenses and facilitating BPH infestation. Apparently, structural and functional mimicry makes it possible for this newly discovered BPH effector to exploit rice OsGF14e-EDR1l immune suppression module. The results reveal a novel mechanism deployed by herbivorous insects, in a manner similar to certain pathogen effectors, to evade host plant defenses by mimicking host immune regulators.}, archive = {J_ADVS}, author = {Jianmei Fu and Shuai Li and jing Li and Zhichang Zhao and Jing Li and Xinyang Tan and Shan Yu and Maofeng Jing and Keyan Zhu-Salzman and Jichao Fang and Rui Ji}, doi = {10.1002/advs.202409186}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2409186}, shortjournal = {Adv. Sci.}, title = {An insect effector mimics its host immune regulator to undermine plant immunity}, volume = {12}, year = {2025}, }
• (2025). Leveraging network target theory for efficient prediction of drug-disease interactions: A transfer learning approach. ADVS, 12(11), 2409130. (www)

  @article{ , abstract = {Efficient virtual screening methods can expedite drug discovery and facilitate the development of innovative therapeutics. This study presents a novel transfer learning model based on network target theory, integrating deep learning techniques with diverse biological molecular networks to predict drug-disease interactions. By incorporating network techniques that leverage vast existing knowledge, the approach enables the extraction of more precise and informative drug features, resulting in the identification of 88,161 drug-disease interactions involving 7,940 drugs and 2,986 diseases. Furthermore, this model effectively addresses the challenge of balancing large-scale positive and negative samples, leading to improved performance across various evaluation metrics such as an Area under curve (AUC) of 0.9298 and an F1 score of 0.6316. Moreover, the algorithm accurately predicts drug combinations and achieves an F1 score of 0.7746 after fine-tuning. Additionally, it identifies two previously unexplored synergistic drug combinations for distinct cancer types in disease-specific biological network environments. These findings are further validated through in vitro cytotoxicity assays, demonstrating the potential of the model to enhance drug development and identify effective treatment regimens for specific diseases.}, archive = {J_ADVS}, author = {Qingyuan Liu and Zizhen Chen and Boyang Wang and Boyu Pan and Zhuoyu Zhang and Miaomiao Shen and Weibo Zhao and Tingyu Zhang and Shao Li and Liren Liu}, doi = {10.1002/advs.202409130}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2409130}, shortjournal = {Adv. Sci.}, title = {Leveraging network target theory for efficient prediction of drug-disease interactions: A transfer learning approach}, volume = {12}, year = {2025}, }
• (2025). Tumor microenvironment-driven structural transformation of vanadium-based MXenzymes to amplify oxidative stress for multimodal tumor therapy. ADVS, 12(11), 2408998. (www)

  @article{ , abstract = {MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal catalytic efficiency and kinetics in the tumor microenvironment (TME). Herein, this study draws inspiration from the electronic structure of transition metal vanadium, proposing the leverage of TME specific-features to induce structural transformations in sheet-like vanadium carbide MXenzymes (TVMz). These transformations trigger cascading catalytic reactions that amplify oxidative stress, thereby significantly enhancing multimodal tumor therapy. Specifically, the engineered HTVMz, coated with hyaluronic acid, exhibits good stability and generates a thermal effect under NIR-II laser irradiation. The thermal effect, combined with TME characteristics, facilities a structural transformation into ultra-small vanadium oxide nanozymes (VO x ). The enlarged surface area of VO x substantially enhances ROS regeneration and amplifies oxidative stress, which promotes lysosomal permeability and induces endoplasmic reticulum stress. The high-valent vanadium in VO x interacts with intracellular glutathione, disrupting redox homeostasis and intensifying oxidative stress further. These amplifications accelerate tumor apoptosis, induce ferroptosis, and suppress HSP90 expression. Consequently, the heightened thermal sensitivity of HTVMz synergistically promotes tumor cell death via multimodal therapeutic pathways. This study presents an innovative strategy for tumor catalytic therapy by manipulating MXenzymes structures, advancing the field of catalytic therapy.}, archive = {J_ADVS}, author = {Hai Zhu and Tinghua Li and Xinhao Peng and Xiaoxian Zhang and Xuequan Zhang and Qiusheng Wang and Lei Lei and Jun Zhang and Bin He and Jun Cao}, doi = {10.1002/advs.202408998}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2408998}, shortjournal = {Adv. Sci.}, title = {Tumor microenvironment-driven structural transformation of vanadium-based MXenzymes to amplify oxidative stress for multimodal tumor therapy}, volume = {12}, year = {2025}, }
• (2025). Galectin-1-induced tumor associated macrophages repress antitumor immunity in hepatocellular carcinoma through recruitment of tregs. ADVS, 12(11), 2408788. (www)

  @article{ , abstract = {Tumor-associated macrophages (TAMs) are commonly considered accomplices in tumorigenesis and tumor development. However, the precise mechanism by which tumor cells prompt TAMs to aid in evading immune surveillance remains to be further investigated. Here, it is elucidated that tumor-secreted galectin-1 (Gal1) conferred immunosuppressive properties to TAMs. Specifically, patient specimens and a public database is first used to analyze the clinical relevance of Gal1 in hepatocellular carcinoma (HCC). Then, it is demonstrated that TAMs functioned as a critical mediator in the Gal1-induced progression of HCC and the establishment of an immunosuppressive tumor microenvironment. Furthermore, RNA-sequencing determined that Gal1 promoted the upregulation of chemokine (C-C motif) ligand 20 (CCL20) in TAMs via activating the PI3K/AKT/NF-κB pathway. Employing an anti-CCL20 neutralizing antibody and Foxp3DTR mice, it is demonstrated that CCR6 + Foxp3 + regulatory T cells (Tregs) recruited by Gal1-induced TAMs contributed to reduced infiltration and dysfunctional state of CD8 + T cells, subsequently facilitating tumor progression. Targeting Gal1 dampened the secretion of CCL20 and inhibits the recruitment of Tregs, thereby activating anti-tumor immunity and ameliorating anti-PD-1 resistance. Together, this findings revealed that Gal1-induced TAMs recruited Tregs through the CCL20-CCR6 axis. Inhibition of Gal1 improves the effectiveness of anti-PD1 therapy, shedding important new light on the combination immunotherapy of HCC.}, archive = {J_ADVS}, author = {Xizhi Yu and Junjie Qian and Limin Ding and Caixu Pan and Xi Liu and Qinchuan Wu and Shuai Wang and Jianpeng Liu and Mingge Shang and Rong Su and Danjing Guo and Haiyang Xie and Shengyong Yin and Lin Zhou and Shusen Zheng}, doi = {10.1002/advs.202408788}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2408788}, shortjournal = {Adv. Sci.}, title = {Galectin-1-induced tumor associated macrophages repress antitumor immunity in hepatocellular carcinoma through recruitment of tregs}, volume = {12}, year = {2025}, }
• (2025). Scale-up of human amniotic epithelial cells through regulation of epithelial-mesenchymal plasticity under defined conditions. ADVS, 12(11), 2408581. (www)

  @article{ , abstract = {Human amniotic epithelial cells (hAECs) have shown excellent efficacy in clinical research and have prospective applications in the treatment of many diseases. However, the properties of the hAECs and their proliferative mechanisms remain unclear. Here, single-cell RNA sequencing (scRNA-seq) is performed on hAECs obtained from amniotic tissues at different gestational ages and passages during in vitro culture. The results showed that the proliferation of hAECs is associated with epithelial-mesenchymal plasticity (EMP) during amniogenesis. Freshly isolated, full-term hAECs are identified as mature epithelial cells. Once cultured in vitro, they are observed to rapidly undergo epithelial-mesenchymal transition (EMT) and enter a partial epithelial-mesenchymal transition (pEMT) state to regain their EMP properties and proliferation capacities. With the continuous development of EMT, hAECs eventually enter a senescent state. The addition of SB431542 and microcarrier screening enabled the effective 3D expansion of hAECs by 50 fold while maintaining the EMP status in hAECs for further proliferation. This study not only elucidated the central proliferation mechanism of hAECs during development and expansion but also optimized the in vitro culture system so that it is sufficient to generate hAECs for 50 patients from a single donor amniotic membrane.}, archive = {J_ADVS}, author = {Wangping Hao and Yi Luo and Jia Tian and Yuefeng Lu and Yangyang Cui and Ying Zhang and Xiao Jin and Hongjuan Ye and Mengqi Lu and Jinjia Song and Weiqing Zhou and Wencheng Zhang and Zhiying He}, doi = {10.1002/advs.202408581}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2408581}, shortjournal = {Adv. Sci.}, title = {Scale-up of human amniotic epithelial cells through regulation of epithelial-mesenchymal plasticity under defined conditions}, volume = {12}, year = {2025}, }
• (2025). Supramolecular modulation of tumor microenvironment through Host−Guest recognition and metal coordination to potentiate cancer chemoimmunotherapy. ADVS, 12(11), 2408518. (www)

  @article{ , abstract = {The massive amount of indoleamine 2,3-dioxygenase 1 (IDO-1) in tumor cells and tumor-associated immune cells forms a feedback loop that maintains immunosuppressive tumor microenvironment (ITM) and causes immune escape, resulting in the poor prognosis of platinum chemotherapeutics. However, the effective systemic administration of platinum drugs and IDO-1 inhibitors is strictly limited by their distinct chemical construction, different pharmacokinetic profiles, and heterogeneous distributions. Herein, a novel supramolecular method with the capability to modulate tumor microenvironment is proposed aiming at potentiating the antitumor efficacy of chemoimmunotherapy. Profiting from the dynamic and reversible merits of noncovalent interactions, IDO-1 inhibitor (IDOi) and 1,2-diaminocyclohexane-platinum(II) (DACHPt) are tailor-encapsulated into supramolecular nanoparticles (SNPs) with the aid of host−guest recognition and metal coordination, respectively, effectively increasing the drug loading and improving their pharmacokinetics. In addition to the authorized chemotherapeutical effect, DACHPt performs a systemic antitumor immune response, which is further magnified by the IDOi-reversed ITM to encourage T lymphocyte infiltration, guaranteeing long-term antitumor immune responses to improve cancer prognosis.}, archive = {J_ADVS}, author = {Dan Wu and Jie Zhou and Zhankui Zhang and Yibin Cao and Kunmin Ping and Shaolong Qi and Jianshi Du and Guocan Yu}, doi = {10.1002/advs.202408518}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2408518}, shortjournal = {Adv. Sci.}, title = {Supramolecular modulation of tumor microenvironment through Host−Guest recognition and metal coordination to potentiate cancer chemoimmunotherapy}, volume = {12}, year = {2025}, }
• (2025). Pharmacological dissection identifies retatrutide overcomes the therapeutic barrier of obese TNBC treatments through suppressing the interplay between glycosylation and ubiquitylation of YAP. ADVS, 12(11), 2407494. (www)

  @article{ , abstract = {Triple-negative breast cancer (TNBC) in obese patients remains challenging. Recent studies have linked obesity to an increased risk of TNBC and malignancies. Through multiomic analysis and experimental validation, a dysfunctional Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H)/Yes-associated protein (YAP) proteolytic axis is identified as a pivotal junction mediating the interplay between cancer-associated adipocytes and the response to anti-cancer drugs in TNBC. Mechanistically, cancer-associated adipocytes drive metabolic reprogramming resulting in an upregulated hexosamine biosynthetic pathway (HBP). This aberrant upregulation of HBP promotes YAP O-GlcNAcylation and the subsequent recruitment of EIF3H deubiquitinase, which stabilizes YAP, thus promoting tumor growth and chemotherapy resistance. It is found that Retatrutide, an anti-obesity agent, inhibits HBP and YAP O-GlcNAcylation leading to increased YAP degradation through the deprivation of EIF3H-mediated deubiquitylation of YAP. In preclinical models of obese TNBC, Retatrutide downregulates HBP, decreases YAP protein levels, and consequently decreases tumor size and enhances chemotherapy efficacy. This effect is particularly pronounced in obese mice bearing TNBC tumors. Overall, these findings reveal a critical interplay between adipocyte-mediated metabolic reprogramming and EIF3H-mediated YAP proteolytic control, offering promising therapeutic strategies to mitigate the adverse effects of obesity on TNBC progression.}, archive = {J_ADVS}, author = {Xin Cui and Yueming Zhu and Lidan Zeng and Mengyuan Zhang and Amad Uddin and Theresa W. Gillespie and Lauren E. McCullough and Shaying Zhao and Mylin A. Torres and Yong Wan}, doi = {10.1002/advs.202407494}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2407494}, shortjournal = {Adv. Sci.}, title = {Pharmacological dissection identifies retatrutide overcomes the therapeutic barrier of obese TNBC treatments through suppressing the interplay between glycosylation and ubiquitylation of YAP}, volume = {12}, year = {2025}, }
• (2025). Muco-penetrating lipid nanoparticles having a liquid core for enhanced intranasal mRNA delivery. ADVS, 12(11), 2407383. (www)

  @article{ , abstract = {Intranasal delivery of mRNA vaccines offers promising opportunities to combat airborne viruses like SARS-CoV-2 by provoking mucosal immunity, which not only defends against respiratory infection but also prevents contagious transmission. However, the development of nasal mRNA vaccines has been hampered by the lack of effective means to overcome the mucus barrier. Herein, ionizable lipid-incorporated liquid lipid nanoparticles (iLLNs) capable of delivering mRNA cargo across airway mucosa are designed. Adjusting the ratios of ionizable and cationic lipids allows fine-tuning of the p K a of iLLNs to the range of nasal mucosal pH (5.5–6.5), thus facilitating mucus penetration via the formation of near-neutral, PEGylated muco-inert surfaces. When nasally administered to mice, the top candidate iLLN-2/mRNA complexes enable about 60-fold greater reporter gene expression in the nasal cavity, compared to the benchmark mRNA-lipid nanoparticles (ALC-LNP) having the same lipid composition as that of BNT162b2 vaccine. Moreover, a prime-boost intranasal immunization of iLLN-2/mRNA complexes elicits a greater magnitude of SARS-CoV-2 spike-specific mucosal IgA and IgG response than ALC-LNP, without triggering any noticeable inflammatory reactions. Taken together, these results provide useful insights for the design of nasally deliverable mRNA formulations for prophylactic applications.}, archive = {J_ADVS}, author = {Nipuni Maniyamgama and Ki Hyun Bae and Zi Wei Chang and Jialing Lee and Melgious J. Y. Ang and Yong Jie Tan and Lisa F. P. Ng and Laurent Renia and Kevin P. White and Yi Yan Yang}, doi = {10.1002/advs.202407383}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2407383}, shortjournal = {Adv. Sci.}, title = {Muco-penetrating lipid nanoparticles having a liquid core for enhanced intranasal mRNA delivery}, volume = {12}, year = {2025}, }
• (2025). ACSL1 aggravates thromboinflammation by LPC/LPA metabolic axis in hyperlipidemia associated myocardial ischemia-reperfusion injury. ADVS, 12(11), 2406359. (www)

  @article{ , abstract = {Acute myocardial infarction (AMI) is associated with well-established metabolic risk factors, especially hyperlipidemia and obesity. Myocardial ischemia-reperfusion injury (mIRI) significantly offsets the therapeutic efficacy of revascularization. Previous studies indicated that disrupted lipid homeostasis can lead to lipid peroxidation damage and inflammation, yet the underlying mechanisms remain unclear. Here, the study demonstrates that hyperlipidemia is a key driver of mIRI. Long-chain fatty acyl-CoA synthetase 1 (ACSL1) is upregulated in both hyperlipidemia and AMI patients. ACSL1 expression is induced by a high-fat microenvironment (oxLDL and palmitic acid) in a concentration-dependent manner. Interestingly, the protein level is positively correlated with total cholesterol level and thromboinflammatory biomarkers. Furthermore, ACSL1 reprogrammed lipid metabolism in monocytes, leading to the accumulation of lysophosphatidylcholine (LPC)/lysophosphatidic acid (LPA). The monocytic LPC/LPA axis accelerated lipid peroxidation and neutrophil extracellular traps (NETs)-induced thromboinflammation via the paracrine effect. The main LPA producer Autotaxinis is also induced under high-fat conditions and then exerts thromboinflammation response through converted LPC to LPA. Finally, ACSL1 knockdown or NETs release inhibitor (DNase I or GSK484) significantly alleviated mIRI in mice. These findings highlight ACSL1 and NETosis as potential key targets for preventing mIRI and underscore the lipid peroxidation in the mechanisms of ACSL1-mediated thromboinflammation.}, archive = {J_ADVS}, author = {Shuai Jiang and Xueguang Lin and Bo Chen and Gang Chen and Kristine J.S. Kwan and Jing Liu and Qi Sun and Jie Wang and Yijie Lu and Jindong Tong and Ying Deng and Bo Yu and Jingdong Tang}, doi = {10.1002/advs.202406359}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2406359}, shortjournal = {Adv. Sci.}, title = {ACSL1 aggravates thromboinflammation by LPC/LPA metabolic axis in hyperlipidemia associated myocardial ischemia-reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Single-cell landscape of bronchoalveolar lavage fluid identifies specific neutrophils during septic immunosuppression. ADVS, 12(11), 2406218. (www)

  @article{ , abstract = {Sepsis-induced immunosuppression is related to increased susceptibility to secondary infections and death. Lung is the most vulnerable target organ in sepsis, but the understanding of the pulmonary immunosuppression state is still limited. Here, single-cell RNA sequencing of bronchoalveolar lavage fluid (BALF) is performed to map the landscape of immune cells, revealing a neutrophil-driven immunosuppressive program in the lungs of patients with immunosuppressive sepsis. Although immunosuppressive genes are upregulated in different immune cells, only neutrophils dramatically increase in the BALF of patients in immunosuppressive phase of sepsis. Five neutrophil subpopulations in BALF are identified, among which CXCR2 + and CD274 ( PD-L1 coding gene) + IL1RN + neutrophil subpopulations increased significantly during septic immunosuppression. Interestingly, a developmental trajectory from CXCR2 + to CD274 + IL1RN + neutrophil subpopulation is disclosed. Moreover, the therapeutic effect of CXCR2 blockade is observed on the survival of septic mice, along with a decreased number of PD-L1 + neutrophils. Taken together, the CXCR2 + neutrophil subpopulation is discovered as a contributor to immunosuppression in sepsis and identified it as a potential therapeutic target in sepsis treatment.}, archive = {J_ADVS}, author = {Rong Shen and Yi Jiang and Guanglong Liu and Shenjia Gao and Hao Sun and Xinyi Wu and Jiahui Gu and Han Wu and Ke Mo and Xing Niu and Ronen Ben-Ami and Wanjing Shang and Jie Zhang and Jun Wang and Changhong Miao and Zhizhang Wang and Wankun Chen}, doi = {10.1002/advs.202406218}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2406218}, shortjournal = {Adv. Sci.}, title = {Single-cell landscape of bronchoalveolar lavage fluid identifies specific neutrophils during septic immunosuppression}, volume = {12}, year = {2025}, }
• (2025). Evenly distributed microporous structure and e7 peptide functionalization synergistically accelerate osteogenesis and angiogenesis in engineered periosteum. ADVS, 12(11), 2406084. (www)

  @article{ , abstract = {Repairing large bone defects remains a significant clinical challenge. Stem cell is of great importance in bone regeneration, and periosteum is rich in periosteal stem cell, which has a great influence on repairing bone defects. Bioengineered periosteum with excellent biocompatibility and stem cell homing capabilities to promote bone regeneration is of great clinical significance. The E7 peptide (EPLQLKM), which exhibits a specific affinity for mesenchymal stem cells (MSCs), is beneficial for modulating cellular functions. In this study, a unique microporous structured carboxymethyl chitosan/sodium alginate membrane with a proper mass ratio is developed by the addition of Poloxam 407 （P407）, which is then functionalized with the E7 affinitive peptide. This membrane, characterized by its microporous structure and E7 peptide functionalization (CSSA/P/E), not only demonstrated favorable mechanical properties, enhanced hydrophilicity, satisfactory biodegradation profile, and excellent biocompatibility, but also synergistically enhanced MSCs recruitment. It is found to promote the proliferation, spreading, and osteogenic differentiation of MSCs in vitro and to accelerate early periosteal regeneration, bone matrix deposition, and vascularization in vivo, leading to effective regeneration of critical-sized bone defects. Overall, this study presents a robust, cell and growth factor-free strategy for bioengineering periosteum, offering a potential solution for the challenging large size bone defects.}, archive = {J_ADVS}, author = {Qihong Li and Chen Li and Jun Yan and Chunli Zhang and Yu Jiang and Xiantong Hu and Liwei Han and Li Li and Peng Wang and Lingzhou Zhao and Yantao Zhao}, doi = {10.1002/advs.202406084}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2406084}, shortjournal = {Adv. Sci.}, title = {Evenly distributed microporous structure and e7 peptide functionalization synergistically accelerate osteogenesis and angiogenesis in engineered periosteum}, volume = {12}, year = {2025}, }
• (2025). 3D printed mesh geometry modulates immune response and interface biology in mouse and sheep model: Implications for pelvic floor surgery. ADVS, 12(11), 2405004. (www)

  @article{ , abstract = {Pelvic organ prolapse (POP) is a highly prevalent yet neglected health burden for women. Strengthening the pelvic floor with bioactive tissue-engineered meshes is an emerging concept. This study investigates tissue regenerative design parameters, including degradability, porosity, and angulation, to develop alternative degradable melt electrowritten (MEW) constructs for surgical applications of POP. MEW constructs were fabricated in hierarchical geometries by two-way stacking of the fibers with three different inter layer angles of 90°, 45°, or 22.5°. Implants printed at 22.5° have higher tensile strength under dry conditions and show better vaginal fibroblast (VF) attachment in vitro. In vivo assessment using preclinical mouse and ovine models demonstrates more effective degradation and improved tissue integration in 22.5° angular meshes compared to 90° and 45° meshes, with evidence of neo-collagen deposition within implants at 6 weeks. The pattern and geometry of the layered MEW implants also influence the foreign body response, wherein the anti-inflammatory phenotype shows a greater ratio of anti-inflammatory CD206+ M2 macrophages/pro-inflammatory CCR7+ M1 macrophages. This presents an attractive strategy for improving the design and fabrication of next-generation vaginal implants for pelvic reconstructive surgery.}, archive = {J_ADVS}, author = {Kallyanashis Paul and Saeedeh Darzi and Cathal D. O'Connell and David M. Z. B. Hennes and Anna Rosamilia and Caroline E. Gargett and Jerome A Werkmeister and Shayanti Mukherjee}, doi = {10.1002/advs.202405004}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2405004}, shortjournal = {Adv. Sci.}, title = {3D printed mesh geometry modulates immune response and interface biology in mouse and sheep model: Implications for pelvic floor surgery}, volume = {12}, year = {2025}, }
• (2025). Aspartate metabolism-driven gut microbiota dynamics and RIP-dependent mitochondrial function counteract oxidative stress. ADVS, 12(11), 2404697. (www)

  @article{ , abstract = {Aspartate (Asp) metabolism-mediated antioxidant functions have important implications for neonatal growth and intestinal health; however, the antioxidant mechanisms through which Asp regulates the gut microbiota and influences RIP activation remain elusive. This study reports that chronic oxidative stress disrupts gut microbiota and metabolite balance and that such imbalance is intricately tied to the perturbation of Asp metabolism. Under normal conditions, in vivo and in vitro studies reveal that exogenous Asp improves intestinal health by regulating epithelial cell proliferation, nutrient uptake, and apoptosis. During oxidative stress, Asp reduces Megasphaera abundance while increasing Ruminococcaceae . This reversal effect depends on the enhanced production of the antioxidant eicosapentaenoic acid mediated through Asp metabolism and microbiota. Mechanistically, the application of exogenous Asp orchestrates the antioxidant responses in enterocytes via the modulation of the RIP3-MLKL and RIP1-Nrf2-NF-κB pathways to eliminate excessive reactive oxygen species and maintain mitochondrial functionality and cellular survival. These results demonstrate that Asp signaling alleviates oxidative stress by dynamically modulating the gut microbiota and RIP-dependent mitochondrial function, providing a potential therapeutic strategy for oxidative stress disease treatment.}, archive = {J_ADVS}, author = {Shunshun Jin and Jian Wu and Chenyu Wang and Yiwen He and Yulong Tang and Le Huang and Hui Zhou and Di Liu and Ziping Wu and Yanzhong Feng and Heshu Chen and Xinmiao He and Guan Yang and Can Peng and Jiazhang Qiu and Tiejun Li and Yulong Yin and Liuqin He}, doi = {10.1002/advs.202404697}, journal = {Advanced Science}, month = {3}, number = {11}, pages = {2404697}, shortjournal = {Adv. Sci.}, title = {Aspartate metabolism-driven gut microbiota dynamics and RIP-dependent mitochondrial function counteract oxidative stress}, volume = {12}, year = {2025}, }
• (2025). Novel leech antimicrobial peptides, hirunipins: Real-time 3D monitoring of antimicrobial and antibiofilm mechanisms using optical diffraction tomography (Adv. sci. 10/2025). ADVS, 12(10), 2570068. (www)

  @article{ , archive = {J_ADVS}, author = {S. Dinesh Kumar and Jeongwon Park and Naveen Kumar Radhakrishnan and Yam Prasad Aryal and Geon-Hwi Jeong and In-Hyeok Pyo and Byambasuren Ganbaatar and Chul Won Lee and Sungtae Yang and Younhee Shin and Sathiyamoorthy Subramaniyam and Yu-jin Lim and Sung-Hak Kim and Seongsoo Lee and Song Yub Shin and Sung-Jin Cho}, doi = {10.1002/advs.202570068}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2570068}, shortjournal = {Adv. Sci.}, title = {Novel leech antimicrobial peptides, hirunipins: Real-time 3D monitoring of antimicrobial and antibiofilm mechanisms using optical diffraction tomography (Adv. sci. 10/2025)}, volume = {12}, year = {2025}, }
• (2025). Artificial intelligence for predicting HER2 status of gastric cancer based on whole-slide histopathology images: A retrospective multicenter study (Adv. sci. 10/2025). ADVS, 12(10), 2570067. (www)

  @article{ , archive = {J_ADVS}, author = {Yuhan Liao and Xinhua Chen and Shupeng Hu and Bing Chen and Xinghua Zhuo and Hao Xu and Xiaojin Wu and Xiaofeng Zeng and Huimin Zeng and Donghui Zhang and Yunfei Zhi and Liang Zhao}, doi = {10.1002/advs.202570067}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2570067}, shortjournal = {Adv. Sci.}, title = {Artificial intelligence for predicting HER2 status of gastric cancer based on whole-slide histopathology images: A retrospective multicenter study (Adv. sci. 10/2025)}, volume = {12}, year = {2025}, }
• (2025). Exosome-mediated lectin pathway and resistin-MIF-AA metabolism axis drive immune dysfunction in immune thrombocytopenia (Adv. sci. 10/2025). ADVS, 12(10), 2570066. (www)

  @article{ , archive = {J_ADVS}, author = {Jin Li and Xiaoqian Wang and Yaoyao Chen and Xianlei Sun and Liyan Fu and Qingxuan Xin and Huilin Zhang and Bo Qin and Nannan Sun and Yingmei Li and Yan Xu and Hui Yang and Dawei Huo and Yong Dong and Shuya Wang and Mengyun Zhao and Quande Lin and Fang Wang and Baohong Yue and Yanxia Gao and Yong Jiang and Rongqun Guo}, doi = {10.1002/advs.202570066}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2570066}, shortjournal = {Adv. Sci.}, title = {Exosome-mediated lectin pathway and resistin-MIF-AA metabolism axis drive immune dysfunction in immune thrombocytopenia (Adv. sci. 10/2025)}, volume = {12}, year = {2025}, }
• (2025). Effects of graphene quantum dots on renal fibrosis through alleviating oxidative stress and restoring mitochondrial membrane potential (Adv. sci. 10/2025). ADVS, 12(10), 2570065. (www)

  @article{ , archive = {J_ADVS}, author = {Kyu Hong Kim and Jong Bo Park and Jung Nam An and Gaeun Bae and Kyu Hyeon Kim and Seong Joon Park and Youngjin Jung and Yong Chul Kim and Jung Pyo Lee and Jae Wook Lee and Dong Ki Kim and Yon Su Kim and Byung Hee Hong and Seung Hee Yang}, doi = {10.1002/advs.202570065}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2570065}, shortjournal = {Adv. Sci.}, title = {Effects of graphene quantum dots on renal fibrosis through alleviating oxidative stress and restoring mitochondrial membrane potential (Adv. sci. 10/2025)}, volume = {12}, year = {2025}, }
• (2025). Enzyme-responsive nanoparachute for targeted miRNA delivery: A protective strategy against acute liver and kidney injury (Adv. sci. 10/2025). ADVS, 12(10), 2570063. (www)

  @article{ , archive = {J_ADVS}, author = {Songhang Li and Yuxuan Zhao and Xiaoying Lyu and Ye Chen and Tao Zhang and Shiyu Lin and Zhiqiang Liu and Xiaoxiao Cai and Taoran Tian and Yunfeng Lin}, doi = {10.1002/advs.202570063}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2570063}, shortjournal = {Adv. Sci.}, title = {Enzyme-responsive nanoparachute for targeted miRNA delivery: A protective strategy against acute liver and kidney injury (Adv. sci. 10/2025)}, volume = {12}, year = {2025}, }
• (2025). MLLT3 regulates melanoma stemness and progression by inhibiting HMGB1 nuclear entry and MAGEA1 M5C modification (Adv. sci. 10/2025). ADVS, 12(10), 2570062. (www)

  @article{ , archive = {J_ADVS}, author = {Yaling Li and Hong Liu and Jingyi Li and Chang Fu and Bin Jiang and Bancheng Chen and Yanfen Zou and Bo Yu and Bing Song}, doi = {10.1002/advs.202570062}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2570062}, shortjournal = {Adv. Sci.}, title = {MLLT3 regulates melanoma stemness and progression by inhibiting HMGB1 nuclear entry and MAGEA1 M5C modification (Adv. sci. 10/2025)}, volume = {12}, year = {2025}, }
• (2025). Tape-assisted residual layer-free one-step nanoimprinting of high-index hybrid polymer for optical loss-suppressed metasurfaces (Adv. sci. 10/2025). ADVS, 12(10), 2570061. (www)

  @article{ , archive = {J_ADVS}, author = {Yujin Park and Joohoon Kim and Younghwan Yang and Dong Kyo Oh and Hyunjung Kang and Hongyoon Kim and Junsuk Rho}, doi = {10.1002/advs.202570061}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2570061}, shortjournal = {Adv. Sci.}, title = {Tape-assisted residual layer-free one-step nanoimprinting of high-index hybrid polymer for optical loss-suppressed metasurfaces (Adv. sci. 10/2025)}, volume = {12}, year = {2025}, }
• (2025). Prediction of patient drug response via 3D bioprinted gastric cancer model utilized patient-derived tissue laden tissue-specific bioink (Adv. sci. 10/2025). ADVS, 12(10), 2570060. (www)

  @article{ , archive = {J_ADVS}, author = {Yoo-mi Choi and Deukchae Na and Goeun Yoon and Jisoo Kim and Seoyeon Min and Hee-Gyeong Yi and Soo-Jeong Cho and Jae Hee Cho and Charles Lee and Jinah Jang}, doi = {10.1002/advs.202570060}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2570060}, shortjournal = {Adv. Sci.}, title = {Prediction of patient drug response via 3D bioprinted gastric cancer model utilized patient-derived tissue laden tissue-specific bioink (Adv. sci. 10/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “Versatile design of NO-generating proteolipid nanovesicles for alleviating vascular injury”. ADVS, 12(10), 2501885. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202501885}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2501885}, shortjournal = {Adv. Sci.}, title = {Correction to “Versatile design of NO-generating proteolipid nanovesicles for alleviating vascular injury”}, volume = {12}, year = {2025}, }
• (2025). Correction to “LncRNA LIMp27 regulates the DNA damage response through p27 in p53-defective cancer cells”. ADVS, 12(10), 2500857. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202500857}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2500857}, shortjournal = {Adv. Sci.}, title = {Correction to “LncRNA LIMp27 regulates the DNA damage response through p27 in p53-defective cancer cells”}, volume = {12}, year = {2025}, }
• (2025). Nano-zinc sulfide modified 3D reconstructed zinc anode with induced deposition effect assists long-cycle stable aqueous zinc ion battery. ADVS, 12(10), 2417323. (www)

  @article{ , abstract = {Aqueous zinc ion batteries are often adversely affected by the poor stability of zinc metal anodes. Persistent water-induced side reactions and uncontrolled dendrite growth have seriously damaged the long-term service life of aqueous zinc ion batteries. In this paper, it is reported that a zinc sulfide with optimized electron arrangement on the surface of zinc anode is used to modify the zinc anode to achieve long-term cycle stability of zinc anode. The effective active sites of the zinc metal anode surface are first significantly improved by a simple ultrasound-assisted etching strategy, and then the in situ zinc sulfide interface phase further guides the zinc ion deposition behavior on the surface of the zinc metal anode. The zinc sulfide protective layer well regulates the interfacial electric field and the migration of Zn 2+ , thereby significantly promoting the homogenization of zinc ion flux to achieve dendrite-free deposition. In addition, the aqueous zinc ion full cell assembled based on ZnS@3D-Zn anode achieves better output performance in long-term cycles. In summary, this work sheds light on the importance of reasonable interfacial modification for the development of dendrite-free and stable zinc anode chemistry, which opens up a new path for promoting the development of zinc-based batteries.}, archive = {J_ADVS}, author = {Dongfang Guo and Fengyu Li and Bin Zhang}, doi = {10.1002/advs.202417323}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2417323}, shortjournal = {Adv. Sci.}, title = {Nano-zinc sulfide modified 3D reconstructed zinc anode with induced deposition effect assists long-cycle stable aqueous zinc ion battery}, volume = {12}, year = {2025}, }
• (2025). Proton exchange membrane with dual-active-center surpasses the conventional temperature limitations of fuel cells. ADVS, 12(10), 2417259. (www)

  @article{ , abstract = {High temperature-proton exchange membrane fuel cells (HT-PEMFC) call for ionomers with low humidity dependence and elevated-temperature resistance. Traditional perfluorosulfonic acid (PFSA) ionomers encounter challenges in meeting these stringent requirements. Herein, this study reports a perfluoroimide multi-acid (PFMA) ionomer with dual active centers achieved through the incorporation of sulfonimide and phosphonic acid groups into the side chain. The fluorocarbon skeleton and multi-acid side chain structure facilitate the segregation of hydrophilic and hydrophobic microphases, augmenting the short-range ordering of hydrophilic nanodomains. Furthermore, the introduction of a rigid segment-benzene ring is employed to decrease side chain flexibility and raise the glass transition temperature. Notably, the prepared membrane exhibits a conductivity of 41 mS cm −1 at 40% relative humidity, showcasing a 1.8 times improvement over that of PFSA. Additionally, the power output of the H 2 -air fuel cell based on this membrane reaches 1.5 W cm −2 at 105 °C, marking a substantial 2.3 times enhancement compared to the PFSA. This work demonstrates the unique advantages of perfluorinated ionomers with multiple protogenic groups in the development of high-performance high-temperature electrolyte materials.}, archive = {J_ADVS}, author = {Yucong Liao and Shengqiu Zhao and Rui wang and Junjie Zhang and Hao Li and Bingxuan Liu and Yao Li and Aojie Zhang and Tian Tian and Haolin Tang}, doi = {10.1002/advs.202417259}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2417259}, shortjournal = {Adv. Sci.}, title = {Proton exchange membrane with dual-active-center surpasses the conventional temperature limitations of fuel cells}, volume = {12}, year = {2025}, }
• (2025). Human-centric, three dimensional micro light-emitting diodes for cosmetic and medical phototherapy. ADVS, 12(10), 2416716. (www)

  @article{ , abstract = {Phototherapy based on micro light-emitting diodes (µLEDs) has gained enormous attention in the medical field as a patient-friendly therapeutic method due to its advantages of minimal invasiveness, fewer side effects, and versatile device form factors with high stability in biological environment. Effective cosmetic and medical phototherapy depends on deep light penetration, precise irradiation, and simultaneous multi-site stimulation, facilitated by three-dimensional (3D) optoelectronics specifically designed for complex human matters, defined here as 3D µLEDs. This perspective article aims to present the functionalities and strategies of 3D µLEDs for human-centric phototherapy. This study investigates the effectiveness of phototherapy enabled by three key functionalities such as shape morphing, self-adaptation, and multilayered spatiotemporal mapping of 3D µLEDs. Finally, this article provides future insights of 3D µLEDs for human-centric phototherapy applications.}, archive = {J_ADVS}, author = {Ki Yun Nam and Min Seo Kim and Jaehun An and Seongwook Min and Jae Hee Lee and Jae Sung Park and Chang-Hun Huh and Seok Hyun Yun and Keon Jae Lee}, doi = {10.1002/advs.202416716}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2416716}, shortjournal = {Adv. Sci.}, title = {Human-centric, three dimensional micro light-emitting diodes for cosmetic and medical phototherapy}, volume = {12}, year = {2025}, }
• (2025). Replicating dynamic immune responses at single-cell resolution within a microfluidic human skin equivalent. ADVS, 12(10), 2415717. (www)

  @article{ , abstract = {To enable in vitro investigation of human skin immunology, this study develops a microfluidic human skin equivalent (HSE) that supports the delivery of circulating immune cells via a vascular microchannel embedded within the dermis of a full-thickness construct. Within this platform, activation of keratinocyte inflammation promotes monocyte migration out of the vascular channel and into the dermal and epidermal compartments. Single-cell transcriptomic analysis reveals dynamic and cell-specific patterns of gene expression that are characteristic of acute activation and resolution of an inflammatory immune response, and the gene signatures of the monocyte-derived cells closely matches the differentiation trajectory of the monocytes into mature dermal macrophages. The microfluidic HSE is also applied to modeling age-associated immune dysfunction and accurately replicates elevated monocyte recruitment in aged skin. Thus, the microfluidic HSE presented here replicates key aspects of dynamic inflammatory immune responses and represents a tractable experimental tool for interrogating mechanisms of human skin immunology.}, archive = {J_ADVS}, author = {Sarah A. Hindle and Holly Bachas Brook and Alexandra Chrysanthou and Emma S. Chambers and Matthew P. Caley and John T. Connelly}, doi = {10.1002/advs.202415717}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2415717}, shortjournal = {Adv. Sci.}, title = {Replicating dynamic immune responses at single-cell resolution within a microfluidic human skin equivalent}, volume = {12}, year = {2025}, }
• (2025). High-performance bi-based catalysts for CO₂ reduction: In situ formation of Bi/Bi₂O₂CO₃ and enhanced formate production. ADVS, 12(10), 2415616. (www)

  @article{ , abstract = {The unavoidable self-reduction of Bismuth (Bi)-based catalysts to zero-valence Bi often results in detrimental adsorption of OCHO * , leading to unsatisfactory selectivity of HCOOH in the electroreduction of carbon dioxide (CO 2 ). A novel Bi-tannin (Bi-TA) complex is developed, which undergoes in situ reconstruction into a Bi/Bi₂O₂CO₃ phase during CO 2 reduction. This reconstructed catalyst exhibits high activity and selectivity, achieving a Faradaic Efficiency (FE) for formate production exceeding 90%, peaking at 96%. Operando spectroscopic and theoretical analyses reveal that the Bi δ+ active site in Bi/Bi₂O₂CO₃ significantly enhances the formation of the OCHO * intermediate, crucial for formate production. The study offers a promising approach to overcoming the limitations of Bi-based catalysts in CO 2 reduction to formate.}, archive = {J_ADVS}, author = {Ben Li and Jiadong Chen and Lihua Wang and De Xia and Shanjun Mao and Lingling Xi and Huajie Liu and Sibin Ying and Yong Wang}, doi = {10.1002/advs.202415616}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2415616}, shortjournal = {Adv. Sci.}, title = {High-performance bi-based catalysts for CO₂ reduction: In situ formation of Bi/Bi₂O₂CO₃ and enhanced formate production}, volume = {12}, year = {2025}, }
• (2025). Overcoming challenges in plant biomechanics: Methodological innovations and technological integration. ADVS, 12(10), 2415606. (www)

  @article{ , abstract = {Plant biomechanics, an emerging interdisciplinary field, plays an irreplaceable role in revealing the structure-function relationships in plant life processes. This field integrates classical mechanical theories with modern biological methods, providing novel perspectives for plant phenotype research and offering significant theoretical guidance for crop breeding, cultivation management, and ecological protection. This review comprehensively examines existing research from three dimensions: research perspectives, methodologies, and content. Using maize lodging as a case study, key scientific questions, research methods, and modeling strategies are analyzed across scales from molecular to population levels. Furthermore, this paper identifies the main challenges in plant biomechanics research, particularly in methodology development, theoretical framework refinement, model simulation, and 3D modeling. Finally, innovative directions and application prospects are explored for integrating plant biomechanics with artificial intelligence technology, multi-scale modeling, genetic improvement, and biomimetics. These research advances will pave new paths for theoretical innovation and practical applications in plant biomechanics.}, archive = {J_ADVS}, author = {Guanmin Huang and Yuankun Li and Ying Zhang and Weiliang Wen and Chunjiang Zhao and Xinyu Guo}, doi = {10.1002/advs.202415606}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2415606}, shortjournal = {Adv. Sci.}, title = {Overcoming challenges in plant biomechanics: Methodological innovations and technological integration}, volume = {12}, year = {2025}, }
• (2025). Spin magnetic effect activate dual site intramolecular O─O bridging for nickel-iron hydroxide enhanced oxygen evolution catalysis. ADVS, 12(10), 2415525. (www)

  @article{ , abstract = {The oxygen evolution reaction (OER) involves the recombination of diamagnetic hydroxyl (OH) or water (H 2 O) into the paramagnetic triplet state of oxygen (O 2 ). The spin conservation of oxygen intermediates plays a crucial role in OER, however, research on spin dynamics during the catalytic process remains in its early stages. Herein, β -Ni(OH) 2 and Fe-doped β -Ni(OH) 2 (Ni 5 Fe 1 (OH) 2 ) are utilized as model catalysts to understand the mechanism of spin magnetic effects at iron (III) sites during OER. Combined with magnetic characterization, it is founded that the introduction of Fe transforms the antiferromagnetic Ni(OH) 2 into a ferromagnetic material. Testing the magnetic response of the catalyst under an external magnetic field, the OER activity of Ni 5 Fe 1 (OH) 2 is significantly enhanced in comparison to Ni(OH) 2 . This improvement is likely due to the introduction of iron sites, which promote spin magnetic effects and enhance reaction kinetics, thereby increasing catalytic efficiency. Combining experimental and theoretical characterization, it is discovered that the iron sites accelerate the formation of heterogeneous dual-site O─O bridging, represented as ─Ni─O─O─Fe─, thereby effectively enhancing the kinetics of the OER reaction. This study provides a magnetic perspective on the structure-function relationship of magnetic iron-based catalysts and has significant implications for the design of new catalysts.}, archive = {J_ADVS}, author = {Haohai Dong and Lanke Luo and Sitong Zhou and Lin Chen and Xinyu Wu and Yitao Yang and Zhensheng Liao and Liao Fu and Ming Chen and Yuxin Zhu and Peiyuan Su and Haomin Jiang and Zemin Sun and Liu Lin and Qingsong Hua}, doi = {10.1002/advs.202415525}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2415525}, shortjournal = {Adv. Sci.}, title = {Spin magnetic effect activate dual site intramolecular O─O bridging for nickel-iron hydroxide enhanced oxygen evolution catalysis}, volume = {12}, year = {2025}, }
• (2025). Reversible ferroelectric polarization modulation of chiral molecular ferroelectrics by circularly polarized light. ADVS, 12(10), 2414977. (www)

  @article{ , abstract = {The optical modulation of ferroelectric polarization constitutes a transformative, non-contact strategy for the precise manipulation of ferroelectric properties, heralding advancements in optically stimulated ferroelectric devices. Despite its potential, progress in this domain is constrained by material limitations and the intricate nature of the underlying mechanisms. Recent studies have achieved efficient regulation of ferroelectric polarization and thermal conductivity in chiral ferroelectric thin films through the application of left- and right-handed circularly polarized light (LCP and RCP). Differential absorption of circularly polarized light (CPL) induces nonequilibrium carrier dynamics, generating distinctive interfacial electrostatic fields that enable precise control of ultrathin ferroelectric films. For (R)-BINOL−DIPASi and (S)-BINOL−DIPASi (C 26 H 26 O 2 Si), polarization changes surpass 23%, exhibiting opposite response under LCP and RCP excitation. In R chiral films, remnant polarization decreases from 1.05 µC cm − 2 under LCP to 0.85 µC cm − 2 under RCP, whereas in S chiral films, polarization increases from 0.85 µC cm − 2 under LCP to 0.98 µC cm − 2 under RCP. This reversible modulation facilitates reliable switching between ON and OFF states, presenting the potential of chiral ferroelectric materials for flexible, high-speed integrated photonic sensor technologies.}, archive = {J_ADVS}, author = {Zhongxuan Wang and Qian Wang and Lina Quan and Shenqiang Ren}, doi = {10.1002/advs.202414977}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414977}, shortjournal = {Adv. Sci.}, title = {Reversible ferroelectric polarization modulation of chiral molecular ferroelectrics by circularly polarized light}, volume = {12}, year = {2025}, }
• (2025). Morphological evolution of sn-metal-based anodes for lithium-ion batteries using operando X-ray imaging. ADVS, 12(10), 2414892. (www)

  @article{ , abstract = {Sn-based electrodes are promising candidates for next-generation lithium-ion batteries. However, it suffers from deleterious micro-structural deformation as it undergoes drastic volume changes upon lithium insertion and extraction. Progress in designing these materials is limited to complex structures. There is a significant need to develop an alloy-based anode that can be industrially manufactured and offers high reversible capacity. This necessitates a profound understanding of the interplay between structural changes and electrochemical performance. Here, operando X-ray imaging is used to correlate the morphological evolution to electrochemical performance in foil and foam systems. The 3D Sn-foam-like structure electrode is fabricated in-house as a practical approach to accommodate the volume expansion and alleviate the mechanical stress experienced upon alloying/dealloying. Results show that generating pores in Sn electrodes can help manage the volume expansion and mitigate the severe mechanical stress in thick electrodes during alloying/dealloying processes. The foam electrode demonstrates superior electrochemical performance compared to non-porous Sn foil with an equivalent absolute capacity. This work advances the understanding of the real-time morphological evolution of Sn bulky electrodes.}, archive = {J_ADVS}, author = {Bouchra Bouabadi and André Hilger and Paul H. Kamm and Tillmann R. Neu and Nikolay Kardjilov and Michael Sintschuk and Henning Markötter and Thomas Schedel-Niedrig and Daniel Abou-Ras and Francisco García-Moreno and Sebastian Risse}, doi = {10.1002/advs.202414892}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414892}, shortjournal = {Adv. Sci.}, title = {Morphological evolution of sn-metal-based anodes for lithium-ion batteries using operando X-ray imaging}, volume = {12}, year = {2025}, }
• (2025). Environmentally friendly and simple recycling of titanium alloy scrap via deoxygenation with hybrid hydrogen plasma arc. ADVS, 12(10), 2414747. (www)

  @article{ , abstract = {The potential of hydrogen plasma arc technology for the efficient deoxygenation and recycling of titanium alloy scrap is explored. The results of thermodynamic analysis reveal that hydrogen plasma is suitable for oxygen removal. The intermediate stages of the deoxygenation process are sequentially analyzed, showing that the hydrogen plasma arc primarily facilitated the reduction and dissolution of oxides as well as eliminated interstitial oxygen. The experimental results demonstrate that the deoxygenation dynamics are governed by the interaction between the hydrogen partial pressure and the surface area of the hydrogen plasma arc irradiation range. Furthermore, the results of the detailed characterization of the recycled titanium alloys indicate that hydrogen plasma arc technology not only reduces the oxygen content to levels compliant with industrial standards for Ti-6Al-4 V but also substantially enhances the tensile strength and ductility of Ti-6Al-4 V compared with those of conventional cast titanium alloys. The results of microstructural analysis show that hydrogen tends to concentrate in the β phase, whereas oxygen is predominantly found in the α phase. These findings highlight the effectiveness of hydrogen plasma arc technology, which offers environmental benefits and improves the performance of the resulting material, indicating its promise as a solution for titanium recycling.}, archive = {J_ADVS}, author = {Botao Jiang and Liang Wang and Guotao Zhou and Xu Liu and Hongyu Lu and Guoqiang Zhu and Jiaxin Du and Chunzhi Zhao and Baoxian Su and Binbin Wang and Ruirun Chen and Yanqing Su}, doi = {10.1002/advs.202414747}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414747}, shortjournal = {Adv. Sci.}, title = {Environmentally friendly and simple recycling of titanium alloy scrap via deoxygenation with hybrid hydrogen plasma arc}, volume = {12}, year = {2025}, }
• (2025). Injured myocardium-targeted theranostic nanoplatform for multi-dimensional immune-inflammation regulation in acute myocardial infarction. ADVS, 12(10), 2414740. (www)

  @article{ , abstract = {Pyroptosis is a key mode of programmed cell death during the early stages following acute myocardial infarction (AMI), driving immune-inflammatory responses. Cardiac resident macrophages (CRMs) are the primary mediators of cardiac immunity, and they serve a dual role through their shaping of both myocardial injury and post-AMI myocardial repair. To appropriately regulate AMI-associated inflammation, HM4oRL is herein designed, an innovative bifunctional therapeutic nanoplatform capable of inhibiting cardiomyocyte pyroptosis while reprogramming inflammatory signaling. This HM4oRL platform is composed of a core of 4-Octyl itaconate (4-OI)-loaded liposomes, a middle layer consisting of a metal-polyphenol network (MPN) film, and an optimized outer hybrid immune-cell membrane layer. The unique properties of this hybrid membrane layer facilitated HM4oRL targeting to the injured myocardium during early-stage AMI in mice, whereupon the release of 4-Ol and modified MPN synergistically inhibited cardiomyocyte pyroptosis while suppressing inflammatory monocytes/macrophage responses at the infarcted site. Mechanistically, HM4oRL preserved cardiac metabolic homeostasis through AMPK signaling activation, establishing favorable microenvironmental conditions for the reprogramming of CRM-mediated inflammation. Ultimately, HM4oRL treatment is able to resolve inflammation, enhance neovascularization, and suppress myocardial fibrosis, reducing the infarct size and enhancing post-AMI cardiac repair such that it is an innovative approach to the targeted treatment of AMI.}, archive = {J_ADVS}, author = {Tao Zheng and Jie Sheng and Zhiyue Wang and Haoguang Wu and Linlin Zhang and Sheng Wang and Jianhua Li and Yunming Zhang and Guangming Lu and Longjiang Zhang}, doi = {10.1002/advs.202414740}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414740}, shortjournal = {Adv. Sci.}, title = {Injured myocardium-targeted theranostic nanoplatform for multi-dimensional immune-inflammation regulation in acute myocardial infarction}, volume = {12}, year = {2025}, }
• (2025). Tuning hydrogen binding on ru sites by ni alloying on MoO2 enables efficient alkaline hydrogen evolution for anion exchange membrane water electrolysis. ADVS, 12(10), 2414622. (www)

  @article{ , abstract = {Ruthenium (Ru)-based electrocatalysts have shown promise for anion exchange membrane water electrolysis (AEMWE) due to their ability to facilitate water dissociation in the hydrogen evolution reaction (HER). However, their performance is limited by strong hydrogen binding, which hinders hydrogen desorption and water re-adsorption. This study reports the development of RuNi nanoalloys supported on MoO 2 , which optimize the hydrogen binding strength at Ru sites through modulation by adjacent Ni atoms. Theoretical simulations reveal that substituting Ni atoms for adjacent Ru atoms reduces the high hydrogen adsorption Gibbs free energy on Ru while maintaining a low energy barrier for water dissociation. As a result, the RuNi/MoO₂ catalyst shows excellent HER performance with a low overpotential of 51 mV at a current density of 100 mA cm⁻ 2 , outperforming commercial Pt/C. Furthermore, RuNi/MoO₂ demonstrates high turnover frequency (7.06 s −1 ), mass activity (13.4 A mg −1 ), and price activity (1030.77 A dollar −1 ). In an AEMWE cell, RuNi/MoO₂ as the cathode catalyst achieves a current density of 1 A cm −2 at 60 °C with just 1.7 V using 1 m KOH. This work highlights the potential of RuNi/MoO₂ for ultra-high mass activity in efficient AEMWE applications.}, archive = {J_ADVS}, author = {Goeun Lee and Sang Eon Jun and Jiheon Lim and Jaehyun Kim and Hyeryeon Lee and Woo Seok Cheon and Geun Woong Ryoo and Byeong-Gwan Cho and Sooheyong Lee and Min Sang Kwon and In-Hyeok Park and Ho Won Jang and Sun Hwa Park and Ki Chang Kwon}, doi = {10.1002/advs.202414622}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414622}, shortjournal = {Adv. Sci.}, title = {Tuning hydrogen binding on ru sites by ni alloying on MoO2 enables efficient alkaline hydrogen evolution for anion exchange membrane water electrolysis}, volume = {12}, year = {2025}, }
• (2025). Rapid synthesis of carbon-supported ru-RuO₂ heterostructures for efficient electrochemical water splitting. ADVS, 12(10), 2414534. (www)

  @article{ , abstract = {Development of high-performance electrocatalysts for water splitting is crucial for a sustainable hydrogen economy. In this study, rapid heating of ruthenium(III) acetylacetonate by magnetic induction heating (MIH) leads to the one-step production of Ru-RuO₂/C nanocomposites composed of closely integrated Ru and RuO₂ nanoparticles. The formation of Mott-Schottky heterojunctions significantly enhances charge transfer across the Ru-RuO 2 interface leading to remarkable electrocatalytic activities toward both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in 1 m KOH. Among the series, the sample prepares at 300 A for 10 s exhibits the best performance, with an overpotential of only −31 mV for HER and +240 mV for OER to reach the current density of 10 mA cm⁻ 2 . Additionally, the catalyst demonstrates excellent durability, with minimal impacts of electrolyte salinity. With the sample as the bifunctional catalysts for overall water splitting, an ultralow cell voltage of 1.43 V is needed to reach 10 mA cm⁻ 2 , 160 mV lower than that with a commercial 20% Pt/C and RuO₂/C mixture. These results highlight the significant potential of MIH in the ultrafast synthesis of high-performance catalysts for electrochemical water splitting and sustainable hydrogen production from seawater.}, archive = {J_ADVS}, author = {Dingjie Pan and Bingzhe Yu and John Tressel and Sarah Yu and Pranav Saravanan and Naya Sangoram and Andrea Ornelas-Perez and Frank Bridges and Shaowei Chen}, doi = {10.1002/advs.202414534}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414534}, shortjournal = {Adv. Sci.}, title = {Rapid synthesis of carbon-supported ru-RuO₂ heterostructures for efficient electrochemical water splitting}, volume = {12}, year = {2025}, }
• (2025). Nanosize non-viral gene therapy reverses senescence reprograming driven by PBRM1 deficiency to suppress iCCA progression. ADVS, 12(10), 2414525. (www)

  @article{ , abstract = {Polybromo-1 (PBRM1) serves as a crucial regulator of gene transcription in various tumors, including intrahepatic cholangiocarcinoma (iCCA). However, the exact role of PBRM1 in iCCA and the mechanism by which it regulates downstream target genes remain unclear. This research has revealed that PBRM1 is significantly downregulated in iCCA tissues, and this reduced expression is linked to aggressive clinicopathological features and a poor prognosis. Furthermore, it is demonstrated that PBRM1 can impede iCCA progression, and a gene therapy nanomedicine is developed to treat iCCA in vivo by modulating PBRM1 expression. The heightened expression of PBRM1 induces by the nanomedicine substantially inhibited tumor growth in iCCA. Conversely, the decrease in PBRM1 results in the abnormal activation of the ERK1/2 signaling pathway, a reduction in p16, p53/p21, and cellular senescence, thereby promoting iCCA advancement. Treatment with U0126, an ERK1/2 inhibitor, effectively halted iCCA progression by regulating the PBRM1-ERK1/2-cellular senescence pathway. These findings underscore the significant role of PBRM1 in controlling iCCA progression and predicting prognosis. Targeting the PBRM1-ERK1/2-cellular senescence pathway with U0126 shows promise for clinical applications in treating iCCA.}, archive = {J_ADVS}, author = {Xiwen Wu and Yi Zhang and Yuan Ding and Jiali Yang and Zimin Song and Shuirong Lin and Ruhe Zhang and Jun Wu and Shunli Shen}, doi = {10.1002/advs.202414525}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414525}, shortjournal = {Adv. Sci.}, title = {Nanosize non-viral gene therapy reverses senescence reprograming driven by PBRM1 deficiency to suppress iCCA progression}, volume = {12}, year = {2025}, }
• (2025). Operando synchrotron X-ray absorption spectroscopy: A key tool for cathode material studies in next-generation batteries. ADVS, 12(10), 2414480. (www)

  @article{ , abstract = {Rechargeable batteries are central to modern energy storage systems, from portable electronics to electric vehicles. The cathode material, a critical component, largely dictates a battery's energy density, capacity, and overall performance. This review focuses on the application of operando X-ray absorption spectroscopy (XAS) to study cathode materials in Li-ion, Na-ion, Li–S, and Na–S batteries. Operando XAS provides real-time insights into the local electronic structure, oxidation states, and coordination environments, which are crucial for understanding complex electrochemical processes, such as redox reactions, phase transitions, and structural degradation. The review highlights the strengths of hard and soft XAS techniques in probing transition metal (TM) and anionic redox processes, particularly in layered oxide cathodes, where reversible oxygen redox and TM behavior are pivotal. The role of operando XAS is also explored in analyzing conversion-type S-based cathodes, where it helps unravel the intricate reaction mechanisms. Furthermore, the review addresses the challenges of in situ cell design for operando XAS, especially under ultrahigh vacuum conditions for soft XAS. By discussing recent advancements and future directions, this review underscores the critical role of operando XAS in driving innovation and improving the design and performance of next-generation battery technologies.}, archive = {J_ADVS}, author = {Yameng Fan and Xin Wang and Guyue Bo and Xun Xu and Khay Wai See and Bernt Johannessen and Wei Kong Pang}, doi = {10.1002/advs.202414480}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414480}, shortjournal = {Adv. Sci.}, title = {Operando synchrotron X-ray absorption spectroscopy: A key tool for cathode material studies in next-generation batteries}, volume = {12}, year = {2025}, }
• (2025). HPV E6/E7-induced acetylation of a peptide encoded by a long non-coding RNA inhibits ferroptosis to promote the malignancy of cervical cancer. ADVS, 12(10), 2414018. (www)

  @article{ , abstract = {Although a fraction of functional peptides concealed within long non-coding RNAs (lncRNAs) is identified, it remains unclear whether lncRNA-encoded peptides are involved in the malignancy of cervical cancer (CC). Here, a 92-amino acid peptide is discovered, which is named TUBORF, encoded by lncRNA TUBA3FP and highly expressed in CC tissues. TUBORF inhibits ferroptosis to promote the malignant proliferation of CC cells. Mechanistically, human papillomavirus (HPV) oncogenes E6 and E7 upregulate TUBORF through CREB-binding protein (CBP)/E1A-binding protein p300 (p300)-mediated histone H3 lysine 27 acetylation (H3K27ac) of lncTUBA3FP enhancer. Furthermore, E6 and E7 elevate and recruit acetyltransferase establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) to bind to and acetylate TUBORF, which facilitates the degradation of immunity-related GTPase Q (IRGQ) via a ubiquitin-proteasome pathway, resulting in the inhibition of ferroptosis and promotion of the malignant proliferation of CC cells. Importantly, silencing ESCO1 or TURORF amplifies anticancer effects by paclitaxel both in CC cells and in vivo. These novel findings reveal oncopeptide TUBORF and its acetyltransferase ESCO1 as important regulators of ferroptosis and tumorigenesis during cervical cancer pathogenesis and establish the scientific basis for targeting these molecules for treating CC.}, archive = {J_ADVS}, author = {Xiaoyu Qi and Jing Zhou and Xinyue Wang and Yan Shen and Yuxun Cao and Liangzi Jiang and Miaomiao Shen and Haoran Zhang and Tianjiao Wang and Pengjun Wei and Ruoqi Xu and Yue Yang and Xiangya Ding and Cong Wang and Xuemei Jia and Qin Yan and Wan Li and Chun Lu}, doi = {10.1002/advs.202414018}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2414018}, shortjournal = {Adv. Sci.}, title = {HPV E6/E7-induced acetylation of a peptide encoded by a long non-coding RNA inhibits ferroptosis to promote the malignancy of cervical cancer}, volume = {12}, year = {2025}, }
• (2025). Targeting TTK inhibits tumorigenesis of T-cell lymphoma through dephosphorylating p38α and activating AMPK/mTOR pathway. ADVS, 12(10), 2413990. (www)

  @article{ , abstract = {T-cell lymphoma (TCL) is a group of non-Hodgkin's lymphoma with high heterogeneity and unfavorable prognosis. Current standard treatments have demonstrated limited efficacy in improving the outcomes for TCL patients. Therefore, identification of novel drug targets is urgently needed to improve the prognosis of TCL patients. Through multi-omics analysis, aberrant expression of threonine tyrosine kinase (TTK) in TCL is identified. High expression of TTK is closely associated with poor prognosis in TCL patients. Targeting TTK through gene knockdown exerts anti-tumor effects in vitro and in vivo, including inhibiting the cell proliferation, inducing G2/M phase arrest, enhancing DNA damage and cell apoptosis. Mechanically, p38α is identified as the potential phosphorylation substrate of TTK through phosphoproteomic quantification and motif prediction. Furthermore, inhibition of TTK suppresses activation of p38α through dephosphorylating it at Thr180/Tyr182, thereby promoting the activation of AMPK/mTOR pathway. In addition, targeting TTK enhances the autophagy in TCL cells through dephosphorylating p38α. CFI-402257, a specific inhibitor of TTK, is found to exhibit anti-tumor effects and exerted synergistic efficacy with PI3K inhibitor, Duvelisib, in TCL. The study shows that TTK contributes to the development of TCL by regulating p38α-mediated AMPK/mTOR pathway. CFI-402257 is expected to be a promising strategy for TCL treatment.}, archive = {J_ADVS}, author = {Bingyu Liu and Tiange Lu and Mengfei Ding and Xiaoli Zhou and Yujie Jiang and Juanjuan Shang and Wenyue Sun and Shunfeng Hu and Xin Wang and Xiangxiang Zhou}, doi = {10.1002/advs.202413990}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2413990}, shortjournal = {Adv. Sci.}, title = {Targeting TTK inhibits tumorigenesis of T-cell lymphoma through dephosphorylating p38α and activating AMPK/mTOR pathway}, volume = {12}, year = {2025}, }
• (2025). Guided multispectral optoacoustic tomography for 3D imaging of the murine colon. ADVS, 12(10), 2413434. (www)

  @article{ , abstract = {Multispectral optoacoustic tomography is a promising medical imaging modality that combines light and sound to provide molecular imaging information at depths of several centimeters, based on the optical absorption of endogenous chromophores, such as hemoglobin. Assessment of inflammatory bowel disease has emerged as a promising clinical application of optoacoustic tomography. In this context, preclinical studies in animal models are essential to identify novel disease-specific imaging biomarkers and understand findings from emerging clinical pilot studies, however to-date, these studies have been limited by the precise identification of the bowel wall. Herein, a transrectal-absorber guide is applied, serving as a high-contrast landmark for 3D optoacoustic tomography of the colon. This study shows that guided multispectral optoacoustic tomography is able to measure changes in blood oxygenation status over the course of acute, chemically-induced colitis in mice and correlates with standard disease activity scores. This novel approach depicts intestinal hemoglobin composition non-invasively during murine inflammation. These results underscore the potential for optoacoustic imaging in translational inflammatory bowel disease research.}, archive = {J_ADVS}, author = {Adrian Buehler and Emma L. Brown and Markus Eckstein and Oana-Maria Thoma and Felix Wachter and Henriette Mandelbaum and Petra Ludwig and Merle Claßen and Mariam-Eleni Oraiopoulou and Ulrich Rother and Markus F. Neurath and Joachim Woelfle and Maximilian J. Waldner and Oliver Friedrich and Ferdinand Knieling and Sarah E. Bohndiek and Adrian P. Regensburger}, doi = {10.1002/advs.202413434}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2413434}, shortjournal = {Adv. Sci.}, title = {Guided multispectral optoacoustic tomography for 3D imaging of the murine colon}, volume = {12}, year = {2025}, }
• (2025). Recent advances in nanoenzymes based therapies for glioblastoma: Overcoming barriers and enhancing targeted treatment. ADVS, 12(10), 2413367. (www)

  @article{ , abstract = {Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor originating from glial cells, characterized by high recurrence rates and poor patient prognosis. The heterogeneity and complex biology of GBM, coupled with the protective nature of the blood–brain barrier (BBB), significantly limit the efficacy of traditional therapies. The rapid development of nanoenzyme technology presents a promising therapeutic paradigm for the rational and targeted treatment of GBM. In this review, the underlying mechanisms of GBM pathogenesis are comprehensively discussed, emphasizing the impact of the BBB on treatment strategies. Recent advances in nanoenzyme-based approaches for GBM therapy are explored, highlighting how these nanoenzymes enhance various treatment modalities through their multifunctional capabilities and potential for precise drug delivery. Finally, the challenges and therapeutic prospects of translating nanoenzymes from laboratory research to clinical application, including issues of stability, targeting efficiency, safety, and regulatory hurdles are critically analyzed. By providing a thorough understanding of both the opportunities and obstacles associated with nanoenzyme-based therapies, future research directions are aimed to be informed and contribute to the development of more effective treatments for GBM.}, archive = {J_ADVS}, author = {Liyin Wang and Min Gu and Xiaoli Zhang and Tingting Kong and Jun Liao and Dan Zhang and Jingwu Li}, doi = {10.1002/advs.202413367}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2413367}, shortjournal = {Adv. Sci.}, title = {Recent advances in nanoenzymes based therapies for glioblastoma: Overcoming barriers and enhancing targeted treatment}, volume = {12}, year = {2025}, }
• (2025). Periodic light modulations for low-cost wide-field imaging of luminescence kinetics under ambient light. ADVS, 12(10), 2413291. (www)

  @article{ , abstract = {Imaging luminescence kinetics is invaluable in many fields, including biology and chemistry. However, the luminescence lifetime of most photo-activated states is in the low ns-µs range and its measurement requires adding costly image intensifiers to cameras to access the fast phenomena present. Here, the Rectified Imaging under Optical Modulation (RIOM) and Heterodyne Imaging under Optical Modulation (HIOM) protocols make this possible with standard low-cost cameras only, even under ambient light. RIOM and HIOM originate from a thorough theoretical analysis, which showed that modulated illumination of any reversibly photoactivable luminophore probed at high frequency generates components of the luminescence response that are detectable at low frequency: RIOM harnesses the mean luminescence response to modulated light at a single frequency, whereas HIOM exploits the luminescence response to modulated light at two close frequencies. When the luminophore behavior obeys a two-state model, the frequency dependence of the RIOM and HIOM observables can be used to extract a photoactivation time. In this work, their ability to retrieve maps of the luminescence lifetime of a reversibly photoswitchable protein, and phosphorescent microsensors are demonstrated. Where the luminophore does not obey a two-state model, RIOM and HIOM can still retrieve rich information, as here exemplified by the recovery of kinetic fingerprints of the physiological state of a plant.}, archive = {J_ADVS}, author = {Hélène Merceron and Ian Coghill and Aliénor Lahlou and Marie-Aude Plamont and Ludovic Jullien and Thomas Le Saux}, doi = {10.1002/advs.202413291}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2413291}, shortjournal = {Adv. Sci.}, title = {Periodic light modulations for low-cost wide-field imaging of luminescence kinetics under ambient light}, volume = {12}, year = {2025}, }
• (2025). Secernin-2 stabilizes histone methyltransferase KMT2C to suppress progression and confer therapeutic sensitivity to PARP inhibition in triple-negative breast cancer. ADVS, 12(10), 2413280. (www)

  @article{ , abstract = {Triple-negative breast cancer (TNBC) is a difficulty and bottleneck in the clinical treatment of breast cancer due to a lack of effective therapeutic targets. Herein, we first report that secernin 2 (SCRN2), an uncharacterized gene in human cancer, acts as a novel tumor suppressor in TNBC to inhibit cancer progression and enhance therapeutic sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition both in vitro and in vivo. SCRN2 is downregulated in TNBC through chaperone-mediated autophagic degradation, and its downregulation is associated with poor patient prognosis. Moreover, SCRN2 impedes the proteasomal degradation of histone-lysine N-methyltransferase 2C (KMT2C) by recruiting Bcl2-associated athanogene 2 to block the interaction of KMT2C with E3 ubiquitin-protein ligase CHIP. Consistently, SCRN2 transcriptionally activates Bcl2-modifying factor by amplifying histone H3 monomethylation at lysine 4 at its enhancer, thereby inducing intrinsic apoptosis. Notably, KMT2C knockdown restores the impaired TNBC progression caused by SCRN2 overexpression both in vitro and in vivo. Furthermore, SCRN2 decreases the expression of key DNA repair-related genes and induces endogenous DNA damage, thus conferring therapeutic sensitivity of TNBC cells to PARP inhibition.   Collectively, these findings identify SCRN2 as a novel suppressor of TNBC, reveal its mechanism of action, and highlight its potential role in TNBC therapy.}, archive = {J_ADVS}, author = {Min-Ying Huang and Jia-Yang Cai and Shao-Ying Yang and Qian Zhao and Zhi-Min Shao and Fang-Lin Zhang and Yin-Ling Zhang and A-Yong Cao and Da-Qiang Li}, doi = {10.1002/advs.202413280}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2413280}, shortjournal = {Adv. Sci.}, title = {Secernin-2 stabilizes histone methyltransferase KMT2C to suppress progression and confer therapeutic sensitivity to PARP inhibition in triple-negative breast cancer}, volume = {12}, year = {2025}, }
• (2025). Pristimerin promotes ubiquitination of HSPA8 and activates the VAV1/ERK pathway to suppress TNBC proliferation. ADVS, 12(10), 2413174. (www)

  @article{ , abstract = {Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis. The natural compound pristimerin has shown promising anti-tumor effect. Here, it is found that pristimerin significantly triggered the activation of autophagy initiation and induced apoptosis in TNBC. Mechanistically, RNA sequencing revealed that pristimerin activated mitogen-activated protein kinase/extracelluar regulated protein kinases (MAPK/ERK) pathway. Drug affinity responsive target stability and mass spectrometry techniques are employed to confirm the direct binding target of pristimerin. Heat shock protein family A member 8 (HSPA8) is identified and verified by cellular thermal shift assays and surface plasmon resonance assays. The further results suggested that pristimerin promoted the ubiquitination and degradation of HSPA8, leading to a decrease in the degradation of Vac Guanine Nucleotide Exchange Factor 1 (VAV1), a downstream client protein of HSPA8 which plays a crucial role in activating the ERK pathway. Importantly, knockdown of HSPA8 or VAV1 significantly impaired the anticancer activity of pristimerin on TNBC cells. Additionally, pristimerin significantly inhibited the migration and invasion of TNBC cells and enhanced the sensitivity of TNBC cells to doxorubicin. Collectively, this study provides the initial evidence that pristimerin directly targets HSPA8 to activate the VAV1/ERK pathway, thereby promoting cell autophagy and apoptosis.}, archive = {J_ADVS}, author = {Qin-Wen Liu and Qi-Ling Fan and Jia-Ying Chen and Jing-Xin Liu and Yi Li and Qian Luo and Yu-Peng Chen and Hang-Tian Wu and An-Qi Xu and Sheng Wang and Ai-Ping Lu and Dao-Gang Guan}, doi = {10.1002/advs.202413174}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2413174}, shortjournal = {Adv. Sci.}, title = {Pristimerin promotes ubiquitination of HSPA8 and activates the VAV1/ERK pathway to suppress TNBC proliferation}, volume = {12}, year = {2025}, }
• (2025). Piezoelectric biomaterial with advanced design for tissue infection repair. ADVS, 12(10), 2413105. (www)

  @article{ , abstract = {Bacterial infection has become the most dangerous factor in tissue repair, which strongly affects the tissue regeneration efficiency and wellness of patients. Piezoelectric materials exhibit the outstanding advantage of producing electrons without external power supply. The ability of electron enrichment and reactive oxygen species generation through noninvasive stimulations enables piezoelectric materials the potential applications of antibacterial. Many studies have proved the feasibility of piezoelectric materials as a functional addition in antibacterial biomaterial. In fact, numerous piezoelectric materials with ingenious designs are reported to be effective in antibacterial processes. This review summarizes the antibacterial mechanisms of piezoelectric, illuminating their potential in combating bacteria. Recent advancement in the design and construction of piezoelectric biomaterial including defect engineering, heterojunction, synergy with metal and the composite scaffold configuration are thoroughly reviewed. Moreover, the applications and therapeutic effects of piezoelectric materials in common tissues with antibacterial requirements are introduced, such as orthopedics, dental, and wound healing. Finally, the development prospects and points deserving further exploration are listed. This review is expected to provide valuable insight into the relationship between antibacterial processes and piezoelectric materials, further inspiring constructive development in this emerging scientific discipline.}, archive = {J_ADVS}, author = {Siyuan Shang and Fuyuan Zheng and Wen Tan and Zhengyi Xing and Siyu Chen and Fuli Peng and Xiang Lv and Duan Wang and Xiangdong Zhu and Jiagang Wu and Zongke Zhou and Xingdong Zhang and Xiao Yang}, doi = {10.1002/advs.202413105}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2413105}, shortjournal = {Adv. Sci.}, title = {Piezoelectric biomaterial with advanced design for tissue infection repair}, volume = {12}, year = {2025}, }
• (2025). The multifaceted roles of BACH1 in disease: Implications for biological functions and therapeutic applications. ADVS, 12(10), 2412850. (www)

  @article{ , abstract = {BTB domain and CNC homolog 1 (BACH1) belongs to the family of basic leucine zipper proteins and is expressed in most mammalian tissues. It can regulate its own expression and play a role in transcriptionally activating or inhibiting downstream target genes. It has a crucial role in various biological processes, such as oxidative stress, cell cycle, heme homeostasis, and immune regulation. Recent research highlights BACH1's significant regulatory roles in a series of conditions, including stem cell pluripotency maintenance and differentiation, growth, senescence, and apoptosis. BACH1 is closely associated with cardiovascular diseases and contributes to angiogenesis, atherosclerosis, restenosis, pathological cardiac hypertrophy, myocardial infarction, and ischemia/reperfusion (I/R) injury. BACH1 promotes tumor cell proliferation and metastasis by altering tumor metabolism and the epithelial-mesenchymal transition phenotype. Moreover, BACH1 appears to show an adverse role in diseases such as neurodegenerative diseases, gastrointestinal disorders, leukemia, pulmonary fibrosis, and skin diseases. Inhibiting BACH1 may be beneficial for treating these diseases. This review summarizes the role of BACH1 and its regulatory mechanism in different cell types and diseases, proposing that precise targeted intervention of BACH1 may provide new strategies for human disease prevention and treatment.}, archive = {J_ADVS}, author = {Xiangxiang Wei and Yunquan He and Yueyang Yu and Sichong Tang and Ruiwen Liu and Jieyu Guo and Qingjun Jiang and Xiuling Zhi and Xinhong Wang and Dan Meng}, doi = {10.1002/advs.202412850}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412850}, shortjournal = {Adv. Sci.}, title = {The multifaceted roles of BACH1 in disease: Implications for biological functions and therapeutic applications}, volume = {12}, year = {2025}, }
• (2025). Intestine-decipher engineered capsules protect against sepsis-induced intestinal injury via broad-spectrum anti-inflammation and parthanatos inhibition. ADVS, 12(10), 2412799. (www)

  @article{ , abstract = {Sepsis is a severe systemic inflammatory syndrome characterized by a dysregulated immune response to infection, often leading to high mortality rates. The intestine, owing to its distinct structure and physiological environment, plays a pivotal role in the pathophysiology of sepsis. It functions as the “central organ” or “engine” in the progression of sepsis, with intestinal injury exacerbating the condition. Despite the availability of current therapies that offer partial symptom relief, they fall short of adequately protecting the intestinal barrier. In this study, an advanced nanodrug formulation (OLA@MΦ NPs) is developed by coating macrophage membranes onto polymeric organic nanoparticles encapsulating olaparib. When loaded into pH-responsive capsules, an intestine-decipher engineered capsule (cp-OLA@MΦ NPs) is successfully formulated. Upon oral administration in septic mice, these capsules withstand gastric acid and release their contents in the intestine, specifically targeting injured tissues. The released OLA@MΦ NPs effectively neutralize pro-inflammatory cytokines via macrophage membrane receptors, while olaparib inhibits intestinal epithelial parthanatos (a form of programmed cell death) by suppressing poly(ADP-ribose) polymerase 1 (PARP1) activation. This strategy significantly reduces bacterial translocation, slows the progression of sepsis, and enhances survival in septic mice, thus presenting a promising therapeutic approach for sepsis in clinical applications.}, archive = {J_ADVS}, author = {Yan Yan and Bin Li and Qiuxia Gao and Miao Wu and Hua Ma and Jiawei Bai and Chengtai Ma and Xinyu Xie and Yuan Gong and Lingqi Xu and Xiaoxue Li and Wei Wang and Yanqiu Wu and Jiamei Wang and Huanhuan Wang and Yi Feng and Yunlong Zhang and Peiran Li and Huimin Shi and Fei Ma and Yue Jia and Han Duan and Xinting Fu and Wenying Wang and Liying Zhan and Xianjin Du and Huiting Zhou and Yuhui Liao}, doi = {10.1002/advs.202412799}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412799}, shortjournal = {Adv. Sci.}, title = {Intestine-decipher engineered capsules protect against sepsis-induced intestinal injury via broad-spectrum anti-inflammation and parthanatos inhibition}, volume = {12}, year = {2025}, }
• (2025). Predicting survival rates in brain metastases patients from non-small cell lung cancer using radiomic signatures associated with tumor immune heterogeneity. ADVS, 12(10), 2412590. (www)

  @article{ , abstract = {Non-small cell lung cancer (NSCLC) frequently metastasizes to the brain, significantly worsened prognoses. This study aimed to develop an interpretable model for predicting survival in NSCLC patients with brain metastases (BM) integrating radiomic features and RNA sequencing data. 292 samples are collected and analyzed utilizing T1/T2 MRIs. Bidirectional stepwise logistic regression is employed to identify significant variables, facilitating the construction of a prognostic model, which is benchmarked against four machine learning algorithms. BM tissue samples are processed for RNA extraction and sequencing. The optimal model achieved an AUC of 0.96 and a C-index of 0.89 in the train set and an AUC of 0.84 with a C-index of 0.78 in the test set, indicating strong predictive performance and generalizability. Patients from Xiangya Hospital are stratified into high-risk (n = 11) and low-risk (n = 30) groups. RNA sequencing revealed an enrichment of immune-related pathways, particularly the interferon (IFN) pathway in the low-risk group. Immune cell infiltration analysis identified a significant presence of CD8 + -T cells, IFNγ-6/-18 in the low-risk group, suggesting an immunologically favorable tumor microenvironment. These findings highlight the potential of combining radiomic and RNA sequencing data for improved survival predictions and personalized treatment strategies in BM patients from NSCLC.}, archive = {J_ADVS}, author = {Fuxing Deng and Gang Xiao and Guilong Tanzhu and Xianjing Chu and Jiaoyang Ning and Ruoyu Lu and Liu Chen and Zijian Zhang and Rongrong Zhou}, doi = {10.1002/advs.202412590}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412590}, shortjournal = {Adv. Sci.}, title = {Predicting survival rates in brain metastases patients from non-small cell lung cancer using radiomic signatures associated with tumor immune heterogeneity}, volume = {12}, year = {2025}, }
• (2025). Collagen nanofiber-lignin composite sponges with adjustable hierarchical pore structure for efficient low-frequency sound absorption. ADVS, 12(10), 2412583. (www)

  @article{ , abstract = {Current sound-absorbing materials, reliant on nonrenewable resources, pose sustainability and disposal challenges. This study introduces a novel collagen-lignin sponge (CLS), a renewable biomass-based material that combines collagen's acoustic properties with lignin's structural benefits. CLSs demonstrate high porosity (>0.97), lightweight (10 mg cm − 3 ), and exceptional broadband noise absorption performance (sound absorption coefficient exceeding 0.9 across 2000–6300 Hz). Due to their unique hierarchical and aligned pore structure, CLSs display superior low-frequency sound-absorbing capabilities and a high noise-reduction coefficient of 0.64 (for a 30-mm-thick sample). A geometric model is also developed to evaluate and predict the sound absorption performance with high consistency to the experimental results. Additionally, the inclusion of lignin as a green crosslinker has significantly improved the thermal stability and compressive strength by ≈600% compared to collagen sponges alone. The innovative integration of collagen and lignin in this study not only leverages the benefits of renewable resources but also presents a cost-effective and straightforward preparation process, positioning CLS as a promising alternative for the construction of sound-absorbing materials seeking sustainable solutions.}, archive = {J_ADVS}, author = {Yan Ma and Mu He and Jiaxuan Wang and Fuying Ma and Hongbo Yu and Yaxian Zhou and Shangxian Xie}, doi = {10.1002/advs.202412583}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412583}, shortjournal = {Adv. Sci.}, title = {Collagen nanofiber-lignin composite sponges with adjustable hierarchical pore structure for efficient low-frequency sound absorption}, volume = {12}, year = {2025}, }
• (2025). Unprecedented ultraviolet circularly polarized light-dependent anomalous photovoltaics in chiral hybrid perovskites. ADVS, 12(10), 2412506. (www)

  @article{ , abstract = {Circularly Polarized Light (CPL)-dependent anomalous photovoltaic effect (APVE), characterized by light helicity-manipulated steady photocurrent and above-bandgap photovoltage, has demonstrated significant potential in the fields of photoelectronic and photovoltaics. However, exploiting CPL-dependent APVE in chiral hybrid perovskites, a promising family with intrinsic chiroptical activity and non-centrosymmetric structure, remains challenging. Here, leveraging the flexible structural design of chiral alternating cations intercalation-type perovskites, CPL-dependent APV, for the first time, is achieved in chiral perovskites. Specifically, by introducing lone pair electrons into the organic layers to greatly amplify the polarization, [(R)-PPA](MOPA)PbBr 4 ( 2-R ) (PPA = 1-phenylpropylammonium, MOPA = 3-methoxypropylammonium) exhibit intrinsic APVE with an above-bandgap photovoltage of 6.50 V ( E g = 3.01 eV) under ultraviolet (UV) light illumination. Strikingly, profiting from the natural chiral optical activity of chiral perovskites, unprecedented UV CPL-dependent APV is realized in 2-R , driving the high distinguishability between right-hand and left-hand CPLs with a large anisotropy factor ( g Iph ) of 0.33. This study pioneers the realization of CPL-dependent APV within chiral perovskite, promising significant advancements in optoelectronic device technologies.}, archive = {J_ADVS}, author = {Qianwen Guan and Peng Xu and Bohui Xu and Huang Ye and Zeng-Kui Zhu and Shiyu Wang and Chengshu Zhang and Hang Li and Chengmin Ji and Zheshuai Lin and Junhua Luo}, doi = {10.1002/advs.202412506}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412506}, shortjournal = {Adv. Sci.}, title = {Unprecedented ultraviolet circularly polarized light-dependent anomalous photovoltaics in chiral hybrid perovskites}, volume = {12}, year = {2025}, }
• (2025). Manipulating fano coupling in an opto-thermoelectric field. ADVS, 12(10), 2412454. (www)

  @article{ , abstract = {Fano resonances in photonics arise from the coupling and interference between two resonant modes in structures with broken symmetry. They feature an uneven and narrow and tunable lineshape and are ideally suited for optical spectroscopy. Many Fano resonance structures have been suggested in nanophotonics over the last ten years, but reconfigurability and tailored design remain challenging. Herein, an all-optical “pick-and-place” approach aimed at assembling Fano metamolecules of various geometries and compositions in a reconfigurable manner is proposed. Their coupling behavior by in situ dark-field scattering spectroscopy is studied. Driven by a light-directed opto-thermoelectric field, silicon nanoparticles with high-quality-factor Mie resonances (discrete states) and low-loss BaTiO 3 nanoparticles (continuum states) are assembled into all-dielectric heterodimers, where distinct Fano resonances are observed. The Fano parameter can be adjusted by changing the resonant frequency of the discrete states or the light polarization. Tunable coupling strength and multiple Fano resonances by altering the number of continuum states and discrete states in dielectric heterooligomers are also shown. This work offers a general design rule for Fano resonance and an all-optical platform for controlling Fano coupling on demand.}, archive = {J_ADVS}, author = {Linhan Lin and Sergey Lepeshov and Alex Krasnok and Yu Huang and Taizhi Jiang and Xiaolei Peng and Brian A. Korgel and Andrea Alù and Yuebing Zheng}, doi = {10.1002/advs.202412454}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412454}, shortjournal = {Adv. Sci.}, title = {Manipulating fano coupling in an opto-thermoelectric field}, volume = {12}, year = {2025}, }
• (2025). Exosome-mediated lectin pathway and resistin-MIF-AA metabolism axis drive immune dysfunction in immune thrombocytopenia. ADVS, 12(10), 2412378. (www)

  @article{ , abstract = {Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. Although antibody-mediated autoimmune reactions are widely recognized as primary factors, the precise etiological agents that trigger ITP remain unidentified. The pathogenesis of ITP remains unclear owing to the absence of comprehensive high-throughput data, except for the belated emergence of autoreactive antibodies. In this study, using flow cytometry (FCM), proteomics, and single-cell RNA sequencing of samples from patients with ITP, it is shown that exosome-mediated lectin complement pathway is involved in the pathogenesis of ITP, which triggers and enlarges the complement activation cascade without effective regulation because of downregulated CD55. The activated complement system enhances the immune response and resistin and further Macrophage Migration Inhibitory Factor (MIF) triggers several proinflammatory signaling pathways, which contribute to the survival of hyperactivated immune cells and dysfunctional arachidonic acid (AA) metabolism. The resistin and MIF are also identified as potential contributors to resistance to glucocorticoid therapy. Taken together, the findings indicate that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ITP treatment, offering novel perspectives on potential therapeutic interventions.}, archive = {J_ADVS}, author = {Jin Li and Xiaoqian Wang and Yaoyao Chen and Xianlei Sun and Liyan Fu and Qingxuan Xin and Huilin Zhang and Bo Qin and Nannan Sun and Yingmei Li and Yan Xu and Hui Yang and Dawei Huo and Yong Dong and Shuya Wang and Mengyun Zhao and Quande Lin and Fang Wang and Baohong Yue and Yanxia Gao and Yong Jiang and Rongqun Guo}, doi = {10.1002/advs.202412378}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412378}, shortjournal = {Adv. Sci.}, title = {Exosome-mediated lectin pathway and resistin-MIF-AA metabolism axis drive immune dysfunction in immune thrombocytopenia}, volume = {12}, year = {2025}, }
• (2025). Covalent affibody-molecular glue drug conjugate nanoagent for proximity-enabled reactive therapeutics. ADVS, 12(10), 2412273. (www)

  @article{ , abstract = {Sulfur-fluoride exchange (SuFEx) reaction is an emerging class of click chemistry reaction. Owing to its efficient reactivity under physiological conditions, SuFEx reaction is used to construct covalent protein drugs. Herein, a covalent affibody-molecular glue drug conjugate nanoagent is reported, which can irreversibly bind with its target protein through proximity-enabled SuFEx reaction. As a proof of concept, a latent bioreactive unnatural amino acid fluorosulfate-L-tyrosine (FSY) is first introduced at site 36 of the affibody with cysteine mutation (Z HER2:342 -Cys) to produce Z HER2:342 -36 FSY -Cys. Subsequently, Z HER2:342 -36 FSY -Cys is coupled with a molecular glue drug (CR8) to yield an amphiphilic conjugate of Z HER2:342 -36 FSY -CR8, which can self-assemble into affibody–drug conjugate nanoagent (Z HER2:342 -36 FSY -CR8 ADCN) in PBS. When Z HER2:342 -36 FSY -CR8 ADCN specific binds to human epidermal growth factor receptor 2 (HER2) on cancer cells, the FSY36 of Z HER2:342 approaches to the His490 of HER2 and ultimately reacts with each other to form a covalent bond via SuFEx reaction. Such a covalent binding mode endows Z HER2:342 -36 FSY -CR8 ADCN with permanent binding ability to effectively increase the concentration of drugs in tumor. Eventually, the covalent Z HER2:342 -36 FSY -CR8 ADCN exhibits an outstanding tumor inhibition ratio of 90.03 ± 4.29% in HER2-positive ovary tumor models, strikingly higher than that of the noncovalent one (64.25 ± 7.71%).}, archive = {J_ADVS}, author = {Wenhui Gao and Xiaoyuan Yang and Qingrong Li and Yingchun Liu and Wei Huang and Xuelin Xia and Deyue Yan}, doi = {10.1002/advs.202412273}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412273}, shortjournal = {Adv. Sci.}, title = {Covalent affibody-molecular glue drug conjugate nanoagent for proximity-enabled reactive therapeutics}, volume = {12}, year = {2025}, }
• (2025). Treatment of denervated muscle atrophy by injectable dual-responsive hydrogels loaded with extracellular vesicles. ADVS, 12(10), 2412248. (www)

  @article{ , abstract = {Denervated muscle atrophy, a common outcome of nerve injury, often results in irreversible fibrosis due to the limited effectiveness of current therapeutic interventions. While extracellular vesicles (EVs) offer promise for treating muscle atrophy, their therapeutic potential is hindered by challenges in delivery and bioactivity within the complex microenvironment of the injury site. To address this issue, an injectable hydrogel is developed that is responsive to both ultrasound and pH, with inherent anti-inflammatory and antioxidant properties, designed to improve the targeted delivery of stem cell-derived EVs. This hydrogel system allows for controlled release of EVs from human umbilical cord mesenchymal stem cells (HUC-MSCs), adapting to the specific conditions of the injury environment. In vivo studies using a rat model of nerve injury demonstrated that the EV-loaded hydrogel (EVs@UR-gel) significantly preserved muscle function. Six weeks post-nerve reconstruction, treated rats exhibited muscle strength, circumference, and wet weight reaching 89.53 ± 0.96%, 76.02 ± 7.49%, and 88.0 ± 2.65% of healthy controls, respectively, alongside an improvement in the sciatic nerve index (−0.11 ± 0.09). This platform presents a novel therapeutic approach by maintaining EV bioactivity, enabling tunable release based on the disease state, and facilitating the restoration of muscle structure and function.}, archive = {J_ADVS}, author = {Ziheng Bu and Jianxing Jing and Wei Liu and Zhen Fan and Junchao Huang and Zheng Zhou and Jianhai Hu and Jinxi An and Jiachang Hong and Jianing Yu and Daolin Tang and Min Sun and Jianzhong Du and Peng Wu}, doi = {10.1002/advs.202412248}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412248}, shortjournal = {Adv. Sci.}, title = {Treatment of denervated muscle atrophy by injectable dual-responsive hydrogels loaded with extracellular vesicles}, volume = {12}, year = {2025}, }
• (2025). Methane bubbled through seawater can be converted to methanol with high efficiency. ADVS, 12(10), 2412246. (www)

  @article{ , abstract = {Partial oxidation of methane (POM) is achieved by forming air-methane microbubbles in saltwater to which an alternating electric field is applied using a copper oxide foam electrode. The solubility of methane is increased by putting it in contact with water containing dissolved KCl or NaCl (3%). Being fully dispersed as microbubbles (20–40 µm in diameter), methane reacts more fully with hydroxyl radicals (OH·) at the gas-water interface. The alternating voltage (100 mV) generates two synergistic POM processes dominated by Cl − → Cl· + e − and O 2 + e − → O 2 −• under positive and negative potentials, respectively. By tuning the frequency and amplitude, the extent and path of the POM process can be precisely controlled so that more than 90% methanol is selectively formed compared to the two byproducts, dichloromethane, and acetic acid. The methane to methanol conversion yield is estimated to be 57% at a rate of approximately 887 µM h −1 . This method appears to have potential for removing methane from air using seawater or for converting higher-concentration methane sources into value-added methanol.}, archive = {J_ADVS}, author = {Xiaowei Song and Chanbasha Basheer and Jinheng Xu and Muhammad Mustapha Adam and Richard N. Zare}, doi = {10.1002/advs.202412246}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412246}, shortjournal = {Adv. Sci.}, title = {Methane bubbled through seawater can be converted to methanol with high efficiency}, volume = {12}, year = {2025}, }
• (2025). The gut microbiota-xanthurenic acid-aromatic hydrocarbon receptor axis mediates the anticolitic effects of trilobatin. ADVS, 12(10), 2412234. (www)

  @article{ , abstract = {Current treatments for ulcerative colitis (UC) remain limited, highlighting the need for novel therapeutic strategies. Trilobatin (TLB), a naturally derived food additive, exhibits potential anti-inflammatory properties. In this study, a dextran sulfate sodium (DSS)-induced animal model is used to investigate the effects of TLB on UC. It is found TLB significantly alleviates DSS-induced UC in mice, as evidenced by a reduction in the disease activity index, an increase in colon length, improvement in histopathological lesions. Furthermore, TLB treatment results in a decrease in proinflammatory cytokines and an increase in anti-inflammatory cytokines. TLB mitigates UC by modulating the intestinal microbiota, particularly Akkermansia , which enhances tryptophan metabolism and upregulates the production of xanthurenic acid (XANA). To confirm the role of TLB-induced microbiota changes, experiments are performed with pseudogerm-free mice and fecal transplantation. It is also identified XANA as a key metabolite that mediates TLB's protective effects. Both TLB and XANA markedly activate the aromatic hydrocarbon receptor (AhR). Administration of an AhR antagonist abrogates their protective effects, thereby confirming the involvement of AhR in the underlying mechanism. In conclusion, the study reveals a novel mechanism through which TLB alleviates UC by correcting microbiota imbalances, regulating tryptophan metabolism, enhancing XANA production, and activating AhR.}, archive = {J_ADVS}, author = {Xiaoyu Wu and Jiajia Wei and Wang Ran and Dongjing Liu and Yang Yi and Miaoxian Gong and Xin Liu and Qihai Gong and Haibo Li and Jianmei Gao}, doi = {10.1002/advs.202412234}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412234}, shortjournal = {Adv. Sci.}, title = {The gut microbiota-xanthurenic acid-aromatic hydrocarbon receptor axis mediates the anticolitic effects of trilobatin}, volume = {12}, year = {2025}, }
• (2025). Gut microbiota-derived hyocholic acid enhances type 3 immunity and protects against salmonella enterica serovar typhimurium in neonatal rats. ADVS, 12(10), 2412071. (www)

  @article{ , abstract = {This study investigates how microbiome colonization influences the development of intestinal type 3 immunity in neonates. The results showed that reduced oxygen levels in the small intestine of neonatal rats induced by Saccharomyces boulardii accelerated microbiome colonization and type 3 immunity development, which protected against Salmonella enterica serovar Typhimurium infection. Microbiome maturation increased the abundance of microbiome-encoded bile salt hydrolase ( BSH ) genes and hyocholic acid (HCA) levels. Furthermore, reducing oxygen levels in the intestine increased the abundance of Limosilactobacillus reuteri , a bacterium encoding BSH , and promoted intestinal type 3 immunity. However, inhibition of BSH blocked the L. reuteri- induced development of intestinal type 3 immunity. Mechanistically, HCA promoted the development of gamma-delta T cells and type 3 innate lymphoid cells by stabilizing the mRNA expression of RAR-related orphan receptor C via the farnesoid X receptor–WT1-associated protein-N6-methyl-adenosine axis. These results reveal that gut microbiota-derived HCA plays a crucial role in promoting the development of intestinal type 3 immunity in neonates. This discovery introduces potential therapeutic avenues for strengthening intestinal immunity in early life or treating bacterial infections by targeting microbial metabolites.}, archive = {J_ADVS}, author = {Zhipeng Yang and Zhiyuan Lin and Yaojie You and Mei Zhang and Ning Gao and Xinru Wang and Jian Peng and Hongkui Wei}, doi = {10.1002/advs.202412071}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2412071}, shortjournal = {Adv. Sci.}, title = {Gut microbiota-derived hyocholic acid enhances type 3 immunity and protects against salmonella enterica serovar typhimurium in neonatal rats}, volume = {12}, year = {2025}, }
• (2025). ZnFe layered double hydroxide nanosheets loaded with cu single-atom nanozymes with multi-enzyme-like catalytic activities as an effective treatment for bacterial keratitis. ADVS, 12(10), 2411999. (www)

  @article{ , abstract = {Bacterial keratitis (BK) is a type of corneal inflammation resulting from bacterial infection in the eye. Although nanozymes have been explored as promising materials in corneal wound healing, currently available nanozymes lack sufficient catalytic activity and the ability to penetrate bacterial biofilms, limiting their efficacy against the treatment of BK. To remedy this, ZnFe layered double hydroxide (ZnFe-LDH) nanosheets are loaded with Cu single-atom nanozymes (Cu-SAzymes) and aminated dextran (Dex-NH 2 ), resulting in the formation of the nanozyme DT-ZnFe-LDH@Cu, which possesses peroxidase (POD)-, oxidase (OXD)-, and catalase (CAT)-like catalytic activities. This enables the nanozyme to generate reactive oxygen species (ROS), such as hydroxyl radicals ( • OH), superoxide anion radical (O 2 •− ), and singlet oxygen ( 1 O 2 ) from hydrogen peroxide (H 2 O 2 ), thereby killing the bacteria causing the infections. The surface Dex-NH 2 enabled the DT-ZnFe-LDH@Cu to penetrate the biofilm and adsorb onto extracellular polymeric substances (EPS) produced by bacteria in the biofilm. Additionally, the DT-ZnFe-LDH@Cu successfully repaired P. aeruginosa -infected corneal injury in a BK rabbit model more effectively than commercially available tobramycin eye drops. This was enabled, in part, by the ability of DT-ZnFe-LDH@Cu to reduce inflammation by promoting the polarization of pro-inflammatory macrophages (M1) to anti-inflammatory macrophages (M2) and decrease the expression of α-smooth muscle actin (α-SMA) to promote wound healing without scar formation. This study provides an innovative concept for the treatment of BK and holds great scientific value and clinical application potential.}, archive = {J_ADVS}, author = {Keke Wang and Mao-sen Yuan and Pengxiu Dai and Jing Li and Anju Tao and Xinke Zhang and Jinyi Wang and Qin Tu}, doi = {10.1002/advs.202411999}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411999}, shortjournal = {Adv. Sci.}, title = {ZnFe layered double hydroxide nanosheets loaded with cu single-atom nanozymes with multi-enzyme-like catalytic activities as an effective treatment for bacterial keratitis}, volume = {12}, year = {2025}, }
• (2025). GABAergic progenitor cell graft rescues cognitive deficits in fragile x syndrome mice. ADVS, 12(10), 2411972. (www)

  @article{ , abstract = {Fragile X syndrome (FXS) is an inherited neurodevelopmental disorder characterized by a range of clinical manifestations with no effective treatment strategy to date. Here, transplantation of GABAergic precursor cells from the medial ganglionic eminence (MGE) is demonstrated to significantly improve cognitive performance in Fmr1 knockout (KO) mice. Within the hippocampus of Fmr1-KO mice, MGE-derived cells from wild-type donor mice survive, migrate, differentiate into functionally mature interneurons, and form inhibitory synaptic connections with host pyramidal neurons. MGE cell transplantation restores Ras-PKB signaling in pyramidal neurons, enhances AMPA receptor trafficking, rescues synaptic plasticity, and corrects abnormal hippocampal neural oscillations. These findings highlight the potential of GABAergic precursor cell transplantation as a promising therapeutic strategy for FXS.}, archive = {J_ADVS}, author = {Chen Wang and Jia-Yu Liu and Li-Da Su and Xin-Tai Wang and Yu-Peng Bian and Zhao-Xiang Wang and Lu-Yu Ye and Xin-Jiang Lu and Lin Zhou and Wei Chen and Wei Yang and Jun Liu and Luxi Wang and Ying Shen}, doi = {10.1002/advs.202411972}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411972}, shortjournal = {Adv. Sci.}, title = {GABAergic progenitor cell graft rescues cognitive deficits in fragile x syndrome mice}, volume = {12}, year = {2025}, }
• (2025). Lightweight MXene composite films with hollow egg-box structures: Enhanced electromagnetic shielding performance beyond pure MXene. ADVS, 12(10), 2411932. (www)

  @article{ , abstract = {MXene is widely used in the electromagnetic interference (EMI) shielding field. However, the high electromagnetic reflectivity of pure MXene causes potential secondary EMI pollution. This study presents a hollow egg-box structure used in MXene composite film, by which the reflectivity (R) could decrease from 0.98 to 0.54 and absorbance (A) increased from 0.02 to 0.45, effectively decreasing the high electromagnetic reflectivity of pure MXene. Additionally, compared to pure MXene films, the MXene composite films exhibit improved electromagnetic interference shielding effectiveness (EMI SE) and SSE/t. The prepared films achieve a peak EMI SE of 69.19 dB at 12.4 GHz, which is 1.3 times higher than pure MXene, and a peak SSE/t of 27 888 dB cm 2 g⁻¹ at 12.4 GHz, 1.4 times that of pure MXene. The hollow egg-box structure not only enhances the electromagnetic shielding performance beyond pure MXene but also demonstrates outstanding performance compared to most reported MXene films, balancing lightweight material properties with effective shielding. Furthermore, the prepared MXene composite films with the hollow egg-box structure show improved water resistance. Therefore, MXene composite films with hollow egg-box structures are promising candidates for advanced EMI devices in future lightweight materials.}, archive = {J_ADVS}, author = {Yijie Wang and Chenxiang Zhao and Yunze Tian and Yue Sun and Mengfei Zhang and Kangjing Wang and Bihua Xia and Yang Wang and Ting Li and Xuhui Zhang and Jing Huang and Shibo Wang and Weifu Dong and Jinliang Qiao}, doi = {10.1002/advs.202411932}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411932}, shortjournal = {Adv. Sci.}, title = {Lightweight MXene composite films with hollow egg-box structures: Enhanced electromagnetic shielding performance beyond pure MXene}, volume = {12}, year = {2025}, }
• (2025). Dopamine drives feedforward inhibition to orexin feeding system, mediating weight loss induced by morphine addiction. ADVS, 12(10), 2411858. (www)

  @article{ , abstract = {Feeding behavior changes induced by opioid addiction significantly contribute to the worsening opioid crisis. Activation of the reward system has shown to provoke binge eating disorder in individuals with opioid use disorder, whereas prolonged opioid exposure leads to weight loss. Understanding the mechanisms underlying these phenomena is essential for addressing this pressing societal issue. This study demonstrates that weight loss resulting from feeding behavior changes during morphine addiction requires the activation of the ventral tegmental area dopamine (DA) system, which suppresses the orexin feeding center. Specifically, DA exerts an inhibitory effect on orexin neurons in the lateral hypothalamus area (LHA) through a feedforward inhibition mediated by GABA neurons in the LHA, involving D1 receptors (D1R) and T-type Ca 2+ channels. Moreover, the morphine addiction-induced reduction in body weight and food intake can be reversed by the D1R antagonist SCH23390 and chemogenetic silencing of GABA neurons in the LHA. These findings delineate a neuromodulatory mechanism underlying morphine addiction-associated feeding behavior changes and weight loss.}, archive = {J_ADVS}, author = {Huiming Li and Sa Wang and Dan Wang and Jiannan Li and Ge Song and Yongxin Guo and Lu Yin and Tingting Tong and Haopeng Zhang and Hailong Dong}, doi = {10.1002/advs.202411858}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411858}, shortjournal = {Adv. Sci.}, title = {Dopamine drives feedforward inhibition to orexin feeding system, mediating weight loss induced by morphine addiction}, volume = {12}, year = {2025}, }
• (2025). Left insula and right middle temporal gyrus dominate cortical network discriminating arousal-dependent emotions. ADVS, 12(10), 2411790. (www)

  @article{ , abstract = {Emotion processing is an integral part of everyone's life. The basic neural circuits involved in emotion perception are becoming clear, though the emotion's cognitive processing remains under investigation. Utilizing the stereo-electroencephalograph with high temporal-spatial resolution, this study aims to decipher the neural pathway responsible for discriminating low-arousal and high-arousal emotions. This study involves 19 patients with pharmacologically resistant epilepsy who participate in a delayed match/mismatch sample task designed to separately assess their ability to discriminate between low-arousal and high-arousal emotions. Three groups of 11 brain subregions, with dominant lateralization, compose a network, which is identified as responsible for discriminating arousal-dependent emotions. The connection of these subregions, leading by the left insula and right middle temporal gyrus, defines the pathways for discriminating emotions with different arousals. Further, the separated network patterns related to emotional discrimination are face-independent. Overall, the left insula and the right middle temporal gyrus emerge as core components in the network, which plays key roles in the dynamic course for discriminating low- and high-arousal emotions in the human brain.}, archive = {J_ADVS}, author = {Na Clara Pan and Runshi Gao and Kai Ma and Liang Qiao and Duanyu Ni and Tao Yu and Yuping Wang}, doi = {10.1002/advs.202411790}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411790}, shortjournal = {Adv. Sci.}, title = {Left insula and right middle temporal gyrus dominate cortical network discriminating arousal-dependent emotions}, volume = {12}, year = {2025}, }
• (2025). Multiple enzymes expressed by the gut microbiota can transform typhaneoside and are associated with improving hyperlipidemia. ADVS, 12(10), 2411770. (www)

  @article{ , abstract = {The mechanism of multiple enzymes mediated drug metabolism in gut microbiota is still unclear. This study explores multiple enzyme interaction process of typhactyloside (TYP) with gut microbiota and its lipid-lowering pharmacological activity. TYP, with bioavailability of only 2.78%, is an active component of Typha angustifolia L . and Pushen capsules which is clinically treated for hyperlipidemia. The metabolic process of TYP is identified, and key enzymes involved in TYP metabolism are validated through gene knockout and overexpression techniques. Through overexpressing α-rhamnosidase (Rha) in Escherichia coli , TYP is verified to metabolize into isorhamnetin-3- O -neohesperidin (M1) and isorhamnetin-3- O -glucoside (M2) after removing rhamnose through Rha. Besides, knockout of β-glucosidase (Glu) confirms that TYP generates M3 through Glu after removing glucose. Combined with molecular docking, M3 is transformed to generate 3,4-dihydroxyphenylacetic acid (M4), protocatechuic acid (M5), and 3-hydroxyphenylacetic acid (M6) through flavonoid reductase (Flr) and chalcone isomerase (Chi). In conclusion, multiple enzymes involved in TYP metabolism (Rha/Glu→Flr→Chi) are identified. Through in vivo experiments, combined use of M3 and M5 also shows excellent anti-hyperlipidemia efficacy. This is the first study on complex metabolism mechanism and pharmacological activity of natural flavonoids mediated by multiple enzymes, which provide insight to investigate analogous natural products.}, archive = {J_ADVS}, author = {Hui Xu and Ru Feng and Meng-Liang Ye and Jia-Chun Hu and Jin-Yue Lu and Jing-Yue Wang and Heng-Tong Zuo and Yi Zhao and Jian-Ye Song and Jian-Dong Jiang and Yun-Zhi Zhou and Yan Wang}, doi = {10.1002/advs.202411770}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411770}, shortjournal = {Adv. Sci.}, title = {Multiple enzymes expressed by the gut microbiota can transform typhaneoside and are associated with improving hyperlipidemia}, volume = {12}, year = {2025}, }
• (2025). Prediction of patient drug response via 3D bioprinted gastric cancer model utilized patient-derived tissue laden tissue-specific bioink. ADVS, 12(10), 2411769. (www)

  @article{ , abstract = {Despite significant research progress, tumor heterogeneity remains elusive, and its complexity poses a barrier to anticancer drug discovery and cancer treatment. Response to the same drug varies across patients, and the timing of treatment is an important factor in determining prognosis. Therefore, development of patient-specific preclinical models that can predict a patient's drug response within a short period is imperative. In this study, a printed gastric cancer (pGC) model is developed for preclinical chemotherapy using extrusion-based 3D bioprinting technology and tissue-specific bioinks containing patient-derived tumor chunks. The pGC model retained the original tumor characteristics and enabled rapid drug evaluation within 2 weeks of its isolation from the patient. In fact, it is confirmed that the drug response-related gene profile of pGC tissues co-cultured with human gastric fibroblasts (hGaFibro) is similar to that of patient tissues. This suggested that the application of the pGC model can potentially overcome the challenges associated with accurate drug evaluation in preclinical models (e.g., patient-derived xenografts) owing to the deficiency of stromal cells derived from the patient. Consequently, the pGC model manifested a remarkable similarity with patients in terms of response to chemotherapy and prognostic predictability. Hence, it is considered a promising preclinical tool for personalized and precise treatments.}, archive = {J_ADVS}, author = {Yoo-mi Choi and Deukchae Na and Goeun Yoon and Jisoo Kim and Seoyeon Min and Hee-Gyeong Yi and Soo-Jeong Cho and Jae Hee Cho and Charles Lee and Jinah Jang}, doi = {10.1002/advs.202411769}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411769}, shortjournal = {Adv. Sci.}, title = {Prediction of patient drug response via 3D bioprinted gastric cancer model utilized patient-derived tissue laden tissue-specific bioink}, volume = {12}, year = {2025}, }
• (2025). 4-octyl itaconate alleviates myocardial ischemia-reperfusion injury through promoting angiogenesis via ERK signaling activation. ADVS, 12(10), 2411554. (www)

  @article{ , abstract = {Myocardial ischemia-reperfusion (IR) injury is a critical complication following revascularization therapy for ischemic heart disease. Itaconate, a macrophage-derived metabolite, has been implicated in inflammation and metabolic regulation. This study investigates the protective role of itaconate derivatives against IR injury. Using a mice model of IR injury, the impact of 7-day 4-Octyl itaconate (4-OI) administration on cardiac function is assessed. Exogenous administration of 4-OI significantly reduces myocardial damage, enhances angiogenesis, and alleviates myocardial hypoxia injury during reperfusion. RNA sequencing and molecular docking techniques are used to find the target of itaconate, and changes in cardiac function are observed in Immune-Responsive Gene1 (IRG1) global knockout mice. In cell culture studies, 4-OI promotes endothelial cell proliferation and migration, mediated by Mitogen-Activated Protein Kinases (MAPK) signaling pathway activation, particularly through Extracellular Signal-Regulated Kinase (ERK) signaling. Inhibition of ERK blocks these beneficial effects on endothelial cells. Furthermore, itaconate synthesis inhibition worsens myocardial damage, which is mitigated by 4-OI supplementation. The results indicate that 4-OI promotes angiogenesis by activating MAPK signaling via FMS-like tyrosine kinase 1 (Flt1), highlighting its potential as a therapeutic strategy for myocardial IR injury.}, archive = {J_ADVS}, author = {Jiqin Yang and Chenqi Duan and Peng Wang and Sijia Zhang and Yuanqing Gao and Shan Lu and Yong Ji}, doi = {10.1002/advs.202411554}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411554}, shortjournal = {Adv. Sci.}, title = {4-octyl itaconate alleviates myocardial ischemia-reperfusion injury through promoting angiogenesis via ERK signaling activation}, volume = {12}, year = {2025}, }
• (2025). Phase transition process of graphite to diamond induced by monodispersed tantalum atoms at ordinary pressure. ADVS, 12(10), 2411504. (www)

  @article{ , abstract = {The transformation of graphite into diamond (2–10 nm) at ordinary pressure by monodispersed Ta atoms was recently reported, while the effects of Ta concentration on the transition process remain obscure. Here, by regulating the Ta wire treatment time, as well as the annealing time and temperature, larger diamond grians (5–20 nm) are successfully synthesized, and the transition process of graphite to diamond is revealed to vary with Ta concentration. Specifically, short Ta wire treatments (5–10 min) induce graphite to form a “circle” structure and transforms into diamond directly after annealing. Long Ta wire treatments (15–25 min) produce larger and more “circle” structures, containing an increased number of graphite layers. After annealing at 1100 °C for 30–120 min, graphite first transforms into amorphous carbon, then to i-Carbon and n-Diamond, and finally to diamond. Notably, a large amount of n-Diamond and diamond are formed after 120 min annealing. By modulating the annealing temperature from 500 to 1200 °C for 30 min, diamond is already obtained at 500 °C, and hexagonal diamond up to 20 nm in size at 1200 °C. This provides a fresh insight into the graphite/diamond transition process and an approach for diamond synthesis.}, archive = {J_ADVS}, author = {Zhiguang Zhu and Chengke Chen and Shaohua Lu and Xiao Li and Xiaojun Hu}, doi = {10.1002/advs.202411504}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411504}, shortjournal = {Adv. Sci.}, title = {Phase transition process of graphite to diamond induced by monodispersed tantalum atoms at ordinary pressure}, volume = {12}, year = {2025}, }
• (2025). CTB6 confers cold tolerance at the booting stage by maintaining tapetum development in rice. ADVS, 12(10), 2411357. (www)

  @article{ , abstract = {Rice is highly sensitive to cold stress, particularly at the booting stage, which significantly threatens rice production. In this study, we cloned a gene, CTB6 , encoding a lipid transfer protein involved in cold tolerance at the booting stage in rice, based on our previous fine-mapped quantitative trait locus (QTL) qCTB10-2 . CTB6 is mainly expressed in the tapetum and young microspores of the anther. CTB6 interacts with catalases (CATs) to maintain their stability, thereby scavenging reactive oxygen species (ROS) accumulation in anthers and facilitating tapetum development under cold stress conditions. Additionally, CTB6 has lipid-binding ability and affects the lipid content in anthers to regulate cold tolerance at the booting stage. Haplotype analysis and promoter activity assay revealed a specific single nucleotide polymorphism (SNP)-489 variation in the promoter of CTB6 , which enhances its expression and results in improved cold tolerance in Hap1-K varieties. The CTB6 near-isogenic line (NIL) exhibited enhanced cold tolerance at the booting stage, with no significant effects on other agronomic traits. Our findings uncover a natural variation of CTB6 for cold tolerance at the booting stage and provide new genetic resources for cold tolerance breeding in rice.}, archive = {J_ADVS}, author = {Shilei Gao and Jin Li and Yawen Zeng and Huahui Li and Zhenhua Guo and Haifeng Guo and Meng Zhang and Yunsong Gu and Runbin Su and Wei Ye and Andong Zou and Xingming Sun and Zhanying Zhang and Hongliang Zhang and Yongmei Guo and Wendong Ma and Pingrong Yuan and Zichao Li and Jinjie Li}, doi = {10.1002/advs.202411357}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411357}, shortjournal = {Adv. Sci.}, title = {CTB6 confers cold tolerance at the booting stage by maintaining tapetum development in rice}, volume = {12}, year = {2025}, }
• (2025). Functionally graded oxide scale on (Hf,Zr,Ti)B2 coating with exceptional ablation resistance induced by unique ti dissolving. ADVS, 12(10), 2411292. (www)

  @article{ , abstract = {Multicomponent Ti-containing ultra-high temperature ceramics (UHTCs) have emerged as more promising ablation-resistant materials than typical UHTCs for applications above 2000 °C. However, the underlying mechanism of Ti improving the ablation performance is still obscure. Here, (Hf,Zr,Ti)B 2 coatings are fabricated by supersonic atmospheric plasma spraying, and the effects of Ti content on the ablation performance under an oxyacetylene flame are investigated. The (Hf 0.45 Zr 0.45 Ti 0.10 )B 2 coating shows superior ablation resistance and cycling reliability at ≈2200°C. A functionally graded oxide scale comprising an outer dense layer and an underlying fine granular layer formed. The former is a better oxygen barrier owing to fewer cracks and the latter has high strain tolerance due to finer grain size. The uniform dissolving of ≈4 mol% Ti in the inner layer results in grain refinement via sluggish diffusion and thus stress release. For the outer layer, Ti segregation at the nanoscale leads to a metastable cubic (Hf,Zr,Ti)O 2 and local severe lattice distortion, inhibiting the propagation of cracks. Ti ions’ unique dissolving in the oxide scale enables a strong oxygen diffusion barrier with high strain tolerance, which is responsible for superior performance. This study provides new insights into the ablation behavior of Ti-containing multicomponent UHTCs.}, archive = {J_ADVS}, author = {Junshuai Lv and Wei Li and Yanqin Fu and Menglin Zhang and Lingxiang Guo and Fanyu Lu and Jiachen Li and Tao Li and Yulei Zhang and Hejun Li}, doi = {10.1002/advs.202411292}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411292}, shortjournal = {Adv. Sci.}, title = {Functionally graded oxide scale on (Hf,Zr,Ti)B2 coating with exceptional ablation resistance induced by unique ti dissolving}, volume = {12}, year = {2025}, }
• (2025). Nanocapsuled neutrophil extracellular trap scavenger combating chronic infectious bone destruction diseases. ADVS, 12(10), 2411274. (www)

  @article{ , abstract = {Chronic infectious bone destruction diseases, such as periodontitis, pose a significant global health challenge. Repairing the bone loss caused by these chronic infections remains challenging. In addition to pathogen removal, regulating host immunity is imperative. The retention of neutrophil extracellular traps (NETs) in chronic infectious niches is found to be a barrier to inflammation resolution. However, whether ruining the existing NETs within the local infectious bone lesions can contribute to inflammation resolve and bone repair remains understudied. Herein, a nanocapsuled delivery system that scavenges NETs dual-responsively to near-infrared light as a switch and to NETs themselves as a microenvironment sensor is designed. Besides, the photothermal and photodynamic effects endow the nanocapsules with antibacterial properties. Together with the ability to clear NETs, these features facilitate the restoration of the normal host response. The immunocorrective properties and inherent pro-osteogenic effects finally promote local bone repair. Together, the NET scavenging nanocapsules address the challenge of impaired bone repair in chronic infections due to biased host response caused by excessive NETs. This study provides new concepts and strategies for repairing bone destruction attributable to chronic infections via correcting biased host responses in chronic infectious diseases.}, archive = {J_ADVS}, author = {Siying Tao and Yingming Yang and Chenzhou Wu and Jiaojiao Yang and Ziyou Wang and Fangjie Zhou and Kunneng Liang and Yi Deng and Jianshu Li and Jiyao Li}, doi = {10.1002/advs.202411274}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411274}, shortjournal = {Adv. Sci.}, title = {Nanocapsuled neutrophil extracellular trap scavenger combating chronic infectious bone destruction diseases}, volume = {12}, year = {2025}, }
• (2025). Enzyme-responsive nanoparachute for targeted miRNA delivery: A protective strategy against acute liver and kidney injury. ADVS, 12(10), 2411210. (www)

  @article{ , abstract = {MicroRNA (miRNA)-based therapy holds significant potential; however, its structural limitations pose a challenge to the full exploitation of its biomedical functionality. Framework nucleic acids are promising owing to their transportability, biocompatibility, and functional editability. MiRNA-125 is embedded into a nucleic acid framework to create an enzyme-responsive nanoparachute (NP), enhancing the miRNA loading capacity while preserving the attributes of small-scale framework nucleic acids and circumventing the uncertainty related to RNA exposure in conventional loading methods. An enzyme-sensitive sequence is designed in NP as a bioswitchable apparatus for cargo miRNAs release. NP is compared with conventional delivery modes and delivery vehicles, confirming its excellent transportability and sustained release properties. Moreover, NP confers good enzyme and serum resistance to the cargo miRNAs. Simultaneously, it can easily deliver miRNA-125 to liver and kidney lesions owing to its passive targeting properties. This allows for Keap1/Nrf2 pathway regulation and p53 protein targeting in the affected tissues. Additionally, NP negatively regulates the expression of Bax and Caspase-3. These combined actions help to inhibit oxidation, prevent cell cycle arrest, and reduce the apoptosis of liver and kidney cells. Consequently, this strategy offers a potential treatment for acute liver and kidney injury.}, archive = {J_ADVS}, author = {Songhang Li and Yuxuan Zhao and Xiaoying Lyu and Ye Chen and Tao Zhang and Shiyu Lin and Zhiqiang Liu and Xiaoxiao Cai and Taoran Tian and Yunfeng Lin}, doi = {10.1002/advs.202411210}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411210}, shortjournal = {Adv. Sci.}, title = {Enzyme-responsive nanoparachute for targeted miRNA delivery: A protective strategy against acute liver and kidney injury}, volume = {12}, year = {2025}, }
• (2025). Combining hard shell with soft core to enhance enzyme activity and resist external disturbances. ADVS, 12(10), 2411196. (www)

  @article{ , abstract = {Immobilizing enzymes onto solid supports having enhanced catalytic activity and resistance to harsh external conditions is considered as a promising and critical method of broadening enzymatic applications in biosensing, biocatalysis, and biomedical devices; however, it is considerably hampered by limited strategies. Here, a core–shell strategy involving a soft-core hexahistidine metal assembly (HmA) is innovatively developed and characterized with encapsulated enzymes (catalase (CAT), horseradish peroxidase, glucose oxidase (GOx), and cascade enzymes (CAT+GOx)) and hard porous shells (zeolitic imidazolate framework (ZIF), ZIF-8, ZIF-67, ZIF-90, calcium carbonate, and hydroxyapatite). The enzyme-friendly environment provided by the embedded HmA proves beneficial for enhanced catalytic activity, which is particularly effective in preserving fragile enzymes that will have been deactivated without the HmA core during the mineralization of porous shells. The enzyme encapsulated within a core–shell particle exhibits noteworthy resilience against harsh external conditions, including heat, organic solvents, and proteinase K. Additionally, no significant alteration in the catalytic behavior of the enzyme is observed after multiple cycles of usage. This study offers a novel approach for immobilizing enzymes and rendering them resistant to harsh external conditions, with potential applications in diverse fields, including biocatalysis, bioremediation, and biomedical engineering.}, archive = {J_ADVS}, author = {Yiwen Wang and Hongfei Tong and Shulan Ni and Kaiyuan Huo and Wenjie Liu and Xingjie Zan and Xiaodie Yuan and Shuangshuang Wang}, doi = {10.1002/advs.202411196}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411196}, shortjournal = {Adv. Sci.}, title = {Combining hard shell with soft core to enhance enzyme activity and resist external disturbances}, volume = {12}, year = {2025}, }
• (2025). Inflammation targeting-triggered healing hydrogel for in situ reconstruction of colonic mucosa. ADVS, 12(10), 2411010. (www)

  @article{ , abstract = {Inflammatory bowel disease (IBD) is characterized by intestinal mucosal damage that exacerbates inflammation and promotes disease recurrence. Although hydrogel-based therapies have shown potential for mucosal repair, challenges remain due to inadequate targeting and low hydrogel density, leading to ongoing infiltration of harmful substances and delayed mucosal healing. In this study, an inflammation-targeting-triggered healing hydrogel (ITTH hydrogel) is developed, composed of polyvinyl alcohol-alginate microgels (PALMs) and a cyclodextrin polymer crosslinker (CPC). This hydrogel specifically targets inflamed colonic sites and crosslinks in situ to form a dense network. The results demonstrate that the ITTH hydrogel adheres effectively to inflamed colonic tissue in both IBD mouse models and human samples. The dense crosslinked network acts like the mucosal barrier, preventing the penetration of detrimental substances such as bacteria and small molecules, thereby protecting the underlying mucosal tissue. Furthermore, the ITTH hydrogel significantly improved therapeutic outcomes in mice with dextran sulfate sodium (DSS)-induced colitis. These findings suggest that the ITTH hydrogel is a promising candidate for in situ reconstruction of colonic mucosa and the treatment of IBD.}, archive = {J_ADVS}, author = {Gaoxian Chen and Xinyi Li and Wei Xu and Haoze Wang and Yichao Jiang and Ruofan Shi and Chengying Zhu and Zeyu Xiao}, doi = {10.1002/advs.202411010}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2411010}, shortjournal = {Adv. Sci.}, title = {Inflammation targeting-triggered healing hydrogel for in situ reconstruction of colonic mucosa}, volume = {12}, year = {2025}, }
• (2025). A baicalin-based functional polymer in dynamic reversible networks alleviates osteoarthritis by cellular interactions. ADVS, 12(10), 2410951. (www)

  @article{ , abstract = {Osteoarthritis (OA) is increasingly recognized as a whole-organ disease predominantly affecting the elderly, characterized by typical alterations in subchondral bone and cartilage, along with recurrent synovial inflammation. Despite the availability of various therapeutics and medications, a complete resolution of OA remains elusive. In this study, novel functional hydrogels are developed by integrating natural bioactive molecules for OA treatment. Specifically, baicalin (Bai) is combined with 2-hydroxyethyl acrylate (HEA) to form a polymerizable monomer (HEA-Bai) through esterification, which is subjected to reversible addition-fragmentation chain transfer (RAFT) polymerization to produce Bai-based polymer (P m ). These macromolecules are incorporated into Schiff-base hydrogels, which demonstrate excellent mechanical properties and self-healing performance. Notably, the Bai-based formulations are taken up by fibroblast-like synoviocytes (FLSs), where they regulate glycolysis. Mechanistically, inhibition of yes-associated protein 1 (YAP1) by the formulations suppressed the FLSs glycolysis and reduced the secretion of inflammatory factors, including interleukin 1β (IL-1β), IL-6, and IL-8. Furthermore, the functional hydrogel (AG-P m )-OC, severing as a lubricant and nutrient, prolonged joint retention of Bai, thereby reducing cartilage degradation and synovial inflammation. Meanwhile, (AG-P m )-OC alleviated joint pain by targeting the YAP1 signaling and inhibiting macrophage recruitment and polarization. Taken together, this flavonoid-based injectable hydrogel exhibits enhanced biocompatibility and efficacy against OA.}, archive = {J_ADVS}, author = {Yili Yang and Qinxiao Hu and Qingfeng Shao and Yachen Peng and Bo Yu and Fangji Luo and Jiajing Chen and Chenhao Xu and Zhenyan Li and Manseng Tam and Zhenyu Ju and Ronghua Zhang and Feiyue Xing and Zhengang Zha and Huan-Tian Zhang}, doi = {10.1002/advs.202410951}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410951}, shortjournal = {Adv. Sci.}, title = {A baicalin-based functional polymer in dynamic reversible networks alleviates osteoarthritis by cellular interactions}, volume = {12}, year = {2025}, }
• (2025). α-ZnO manipulated growth of ag gird on AgNWs enables high conductive flexible electrode for large-area monolithic organic photovoltaics. ADVS, 12(10), 2410931. (www)

  @article{ , abstract = {The conductivity of AgNWs electrodes can be enhanced by incorporating Ag grids, thereby facilitating the development of large-area flexible organic solar cells (FOSCs). Ag grids from vacuum evaporation offer the advantages of simple film formation, adjustable thickness, and unique structure. However, the complex 3D multi-component structure of AgNWs electrodes will exacerbate the aggregation of large Ag particles, causing the device short circuits. To address this issue, the relationship between the surface energy of modification layers and the morphology and conductivity of ultrathin Ag on AgNWs is studied. The amorphous ZnO (α-ZnO) layer promotes Ag growth from Volmer–Weber (VW) to Frank–Van der Merwe (FM), reducing particle aggregation. The 1 µm thick PET/AgNWs/Ag grid electrode with α-ZnO exhibited low contact resistance and high conductivity. As a result, 1 cm 2 FOSCs with Ag grids achieve a power conversion efficiency (PCE) of 16.01%. As the area increased to 4 and 9 cm 2 , the performance of the monolithic FOSCs is 14.70% and 12.69%, showing less efficiency loss during upscaling. The 8 and 16 cm 2 modules constructed by series and parallel connection of the monolithic devices yield PCEs of 14.47% and 12.92%, respectively. This study offers valuable insights into constructing Ag grids on AgNWs electrodes for highly efficient large-area FOSCs.}, archive = {J_ADVS}, author = {Zhuo Chen and Tianyu Liu and Irfan Ismail and Fan Qian and Lianping Zhang and Shutao Yang and Xiaoke Zhang and Lingpeng Yan and Yunfei Han and Qun Luo and Yongzhen Yang and Chang-Qi Ma}, doi = {10.1002/advs.202410931}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410931}, shortjournal = {Adv. Sci.}, title = {α-ZnO manipulated growth of ag gird on AgNWs enables high conductive flexible electrode for large-area monolithic organic photovoltaics}, volume = {12}, year = {2025}, }
• (2025). Coplanar dimeric acceptors with bathochromic absorption and torsion-free backbones through precise fluorination enabling efficient organic photovoltaics with 18.63% efficiency. ADVS, 12(10), 2410826. (www)

  @article{ , abstract = {Giant dimeric acceptors (GDAs), a sub-type of acceptor materials for organic solar cells (OSCs), have garnered much attention due to the synergistic advantages of their monomeric and polymeric acceptors, forming a well-defined molecular structure with a giant molecular weight for high efficiency and stability. In this study, for the first time, two new GDAs, DYF-V and DY2F-V are designed and synthesized for OSC operation, by connecting one vinylene linker with the mono-/di-fluorinated end group on two Y-series monomers, respectively. After fluorination, both DYF-V and DY2F-V exhibit bathochromic absorption and denser packing modes due to the stronger intramolecular charge transfer effect and torsion-free backbones. Through precise fluorination, the DYF-V-based devices exhibit the highest performance of 18.63% among the GDA-based OSCs, outperforming its non-fluorinated counterpart, DY-V-based ones (16.53%). Theoretical and morphological results demonstrate that proper fluorination in DYF-V-based devices strengthens intra/intermolecular interactions for enhanced crystallinity, superior phase segregation, and less energy disorder, which is beneficial for fast exciton dissociation, rapid carrier transport, and suppressed charge recombination. The work demonstrates that proper fluorination on GDAs with rigid coplanar backbones is effective for broader photon harvesting, stronger packing, and robust stability in GDA-based OSCs.}, archive = {J_ADVS}, author = {Wei Liu and Weiwei Wu and Aleksandr A. Sergeev and Jia Yao and Yuang Fu and Chung Hang Kwok and Ho Ming Ng and Chunliang Li and Xiaojun Li and Sai Ho Pun and Huawei Hu and Xinhui Lu and Kam Sing Wong and Yongfang Li and He Yan and Han Yu}, doi = {10.1002/advs.202410826}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410826}, shortjournal = {Adv. Sci.}, title = {Coplanar dimeric acceptors with bathochromic absorption and torsion-free backbones through precise fluorination enabling efficient organic photovoltaics with 18.63% efficiency}, volume = {12}, year = {2025}, }
• (2025). Effects of graphene quantum dots on renal fibrosis through alleviating oxidative stress and restoring mitochondrial membrane potential. ADVS, 12(10), 2410747. (www)

  @article{ , abstract = {Podocyte injury and proteinuria in glomerular disease are critical indicators of acute kidney injury progression to chronic kidney disease. Renal mitochondrial dysfunction, mediated by intracellular calcium levels and oxidative stress, is a major contributor to podocyte complications. Despite various strategies targeting mitochondria to improve kidney function, effective treatments remain lacking. This study investigates the potential of graphene quantum dots (GQDs) in mitigating renal fibrosis and elucidates their underlying mechanisms. In animal models of Adriamycin-induced nephropathy and 5/6 subtotal nephrectomy, GQDs treatment exhibits anti-inflammatory, anti-fibrotic, and anti-apoptotic effects by restoring podocyte actin structure. These therapeutic benefits are associated with the downregulation of transient receptor potential channel 5 (TRPC5) activity, which is related to kidney fibrosis and mitochondrial dysfunction. In vitro, GQDs suppress TRPC5, enhancing anti-fibrotic and anti-apoptotic effects by lowering calcium levels under oxidative stress and mechanical pressure. Anti-oxidative and anti-senescent effects are also confirmed. Most significantly, transcriptomics and electron microscopy analyses reveal that GQD treatment enhances mitochondrial respiration-related gene profiles and improves mitochondrial cristae morphology. These findings suggest that GQDs are a promising therapeutic nanomaterial for renal cell damage, capable of modulating calcium-dependent apoptosis associated with mitochondrial injury, potentially slowing fibrosis progression.}, archive = {J_ADVS}, author = {Kyu Hong Kim and Jong Bo Park and Jung Nam An and Gaeun Bae and Kyu Hyeon Kim and Seong Joon Park and Youngjin Jung and Yong Chul Kim and Jung Pyo Lee and Jae Wook Lee and Dong Ki Kim and Yon Su Kim and Byung Hee Hong and Seung Hee Yang}, doi = {10.1002/advs.202410747}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410747}, shortjournal = {Adv. Sci.}, title = {Effects of graphene quantum dots on renal fibrosis through alleviating oxidative stress and restoring mitochondrial membrane potential}, volume = {12}, year = {2025}, }
• (2025). Carbon flow in acidic CO2 electroreduction. ADVS, 12(10), 2410679. (www)

  @article{ , abstract = {Electrochemical CO 2 reduction in acidic media attracts extensive research attention due to its potential in increasing carbon efficiency. In most reports, alkali cations are introduced to suppress hydrogen evolution and to promote CO 2 reduction. However, the mass transport of alkali cations through cation exchange membrane induces the change of electrolyte compositions. Herein, the variation of electrolyte compositions and the flow of carbon during CO 2 reduction are analyzed quantitatively by simulation and experiments. If the initial amount of alkali cations in the anolyte is higher than the initial amount of H + in the catholyte, the pH of the catholyte increases remarkably in long-term CO 2 reduction electrolysis, resulting in the decrease of carbon efficiency. Bicarbonate salt precipitation on the cathode with alkali cation-containing catholyte is another origin of the decrease of CO 2 reduction Faradaic efficiency and carbon efficiency. To maintain high carbon efficiency, the electrolyte should contain low concentration of alkali cations or even be free of alkali cations. Decorating the catalyst of cathode with ionomer with high density of cation sites enables CO 2 reduction in pure acid solution, achieving 30-h stable carbon efficiency.}, archive = {J_ADVS}, author = {Xiao-Shuang Zhou and Yi-Yang Bai and Bo Cao and Lin-Feng Yang and Fu-Zhi Li and Hai-Gang Qin and Li-Na Chen and Long Chen and Jun Gu}, doi = {10.1002/advs.202410679}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410679}, shortjournal = {Adv. Sci.}, title = {Carbon flow in acidic CO2 electroreduction}, volume = {12}, year = {2025}, }
• (2025). ABCA6 regulates chondrogenesis and inhibits joint degeneration via orchestrated cholesterol efflux and cellular senescence. ADVS, 12(10), 2410414. (www)

  @article{ , abstract = {Patellar dysplasia (PD) can cause patellar dislocation and subsequent osteoarthritis (OA) development. Herein, a novel ABCA6 mutation contributing to a four-generation family with familiar patellar dysplasia (FPD) is identified. In this study, whole exome sequencing (WES) and genetic linkage analysis across a four-generation lineage presenting with six cases of FPD are conducted. A disease-causing mutation in ABCA6 is identified for FPD. Further analyses reveal a consistent correlation between ABCA6 expression downregulation and PD occurrence, chondrocyte degeneration, and OA onset. Moreover, ABCA6-KO mice demonstrate severe knee joint degeneration and accelerated OA progression. Besides, synovial mesenchymal stem cells (SMSCs) are extracted from WT, ABCA6 −/+ , and ABCA6 −/− mice to create chondrogenic organoids in vitro, confirming ABCA6 deficiency can lead to chondrocyte degeneration via modulating cell cycle and activating cellular senescence. Moreover, transcriptome and metabolomic sequencing analysis on ABCA6-KO chondrocytes unveils that the ABCA6 deficiency inhibits cholesterol efflux, leading to intracellular cholesterol accumulation and subsequent cellular senescence and impaired chondrogenesis.A disease-causing mutation of ABCA6 is identified for FPD. ABCA6 is correlated with PD occurrence and subsequent OA progression. ABCA6 can serve as a potential target in chondrogenesis and OA treatment by orchestrated intracellular cholesterol efflux and delayed cellular senescence.}, archive = {J_ADVS}, author = {Yi Wang and Qiang Wu and Yongqing You and Wenbo Jiang and Peiliang Fu and Kerong Dai and Ye Sun}, doi = {10.1002/advs.202410414}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410414}, shortjournal = {Adv. Sci.}, title = {ABCA6 regulates chondrogenesis and inhibits joint degeneration via orchestrated cholesterol efflux and cellular senescence}, volume = {12}, year = {2025}, }
• (2025). Peptide-drug conjugate for therapeutic reprogramming of tumor-associated macrophages in breast cancer. ADVS, 12(10), 2410288. (www)

  @article{ , abstract = {In triple-negative breast cancer (TNBC), pro-tumoral macrophages promote metastasis and suppress the immune response. To target these cells, a previously identified CD206 (mannose receptor)-binding peptide, mUNO was engineered to enhance its affinity and proteolytic stability. The new rationally designed peptide, MACTIDE, includes a trypsin inhibitor loop, from the Sunflower Trypsin Inhibitor-I. Binding studies to recombinant CD206 revealed a 15-fold lower K D for MACTIDE compared to parental mUNO. Mass spectrometry further demonstrated a 5-fold increase in MACTIDE's half-life in tumor lysates compared to mUNO. Homing studies in TNBC-bearing mice shows that fluorescein (FAM)-MACTIDE precisely targeted CD206 + tumor-associated macrophages (TAM) upon intravenous, intraperitoneal, and even oral administration, with minimal liver accumulation. MACTIDE was conjugated to Verteporfin, an FDA-approved photosensitizer and YAP/TAZ pathway inhibitor to create the conjugate MACTIDE-V. In the orthotopic 4T1 TNBC mouse model, non-irradiated MACTIDE-V-treated mice exhibited anti-tumoral effects comparable to those treated with irradiated MACTIDE-V, with fewer signs of toxicity, prompting further investigation into the laser-independent activity of the conjugate. In vitro studies using bone marrow-derived mouse macrophages showed that MACTIDE-V excluded YAP from the nucleus, increased phagocytic activity, and upregulated several genes associated with cytotoxic anti-tumoral macrophages. In mouse models of TNBC, MACTIDE-V slowed primary tumor growth, suppressed lung metastases, and increased markers of phagocytosis and antigen presentation in TAM and monocytes, increasing the tumor infiltration of several lymphocyte subsets. MACTIDE-V is proposed as a promising peptide-drug conjugate for modulating macrophage function in breast cancer immunotherapy.}, archive = {J_ADVS}, author = {Anni Lepland and Elisa Peranzoni and Uku Haljasorg and Eliana K. Asciutto and Maria Crespí-Amer and Lorenzo Modesti and Kalle Kilk and Manuel Lombardia and Gerardo Acosta and Miriam Royo and Pärt Peterson and Ilaria Marigo and Tambet Teesalu and Pablo Scodeller}, doi = {10.1002/advs.202410288}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410288}, shortjournal = {Adv. Sci.}, title = {Peptide-drug conjugate for therapeutic reprogramming of tumor-associated macrophages in breast cancer}, volume = {12}, year = {2025}, }
• (2025). Genetically engineered brain organoids recapitulate spatial and developmental states of glioblastoma progression. ADVS, 12(10), 2410110. (www)

  @article{ , abstract = {Glioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy due to significant intra-tumoral heterogeneity. The lack of robust in vitro models to study early tumor progression has hindered the development of effective therapies. Here, this study develops engineered GBM organoids (eGBOs) harboring GBM subtype-specific oncogenic mutations to investigate the underlying transcriptional regulation of tumor progression. Single-cell and spatial transcriptomic analyses revealed that these mutations disrupt normal neurodevelopment gene regulatory networks resulting in changes in cellular composition and spatial organization. Upon xenotransplantation into immunodeficient mice, eGBOs form tumors that recapitulate the transcriptional and spatial landscape of human GBM samples. Integrative single-cell trajectory analysis of both eGBO-derived tumor cells and patient GBM samples reveal the dynamic gene expression changes in developmental cell states underlying tumor progression. This analysis of eGBOs provides an important validation of engineered cancer organoid models and demonstrates their utility as a model of GBM tumorigenesis for future preclinical development of therapeutics.}, archive = {J_ADVS}, author = {Matthew Ishahak and Rowland H. Han and Devi Annamalai and Timothy Woodiwiss and Colin McCornack and Ryan T. Cleary and Patrick A. DeSouza and Xuan Qu and Sonika Dahiya and Albert H. Kim and Jeffrey R. Millman}, doi = {10.1002/advs.202410110}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410110}, shortjournal = {Adv. Sci.}, title = {Genetically engineered brain organoids recapitulate spatial and developmental states of glioblastoma progression}, volume = {12}, year = {2025}, }
• (2025). Ferrites with a minimized secondary electron yield. ADVS, 12(10), 2410083. (www)

  @article{ , abstract = {Ferrites are an essential material in modern industry due to their exceptional magnetic properties and high resistivity. Many applications of ferrites necessitate exposure to high energy electrons, particularly space science and particle accelerators, where charging, multipacting, and electron clouds (ECs) are major issues. ECs are of particular concern around the Ni/Zn soft ferrite kicker magnets as the large hadron collider (LHC) undergoes its high luminosity upgrade. Here, laser engineered surface structures (LESS) are used to reduce the secondary electron yield (SEY) of Ni/Zn ferrites from 2.1 to its experimentally determined minimum of 0.81, eliminating the ferrites ability to contribute to the formation of ECs. This demonstrates the applicability of LESS outside of metals and its broader applicability to reducing the SEY of technical materials.}, archive = {J_ADVS}, author = {Robin Uren and Manuel Hoffman and Amin Din and Stefan Wackerow and Holger Neupert and Stephan Pfeiffer and Alice Moros and Michael Barnes and Giorgia Favia and Marcel Himmerlich and Amin Abdolvand}, doi = {10.1002/advs.202410083}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2410083}, shortjournal = {Adv. Sci.}, title = {Ferrites with a minimized secondary electron yield}, volume = {12}, year = {2025}, }
• (2025). MiR-32533 reduces cognitive impairment and amyloid-β overload by targeting CREB5-mediated signaling pathways in alzheimer's disease. ADVS, 12(10), 2409986. (www)

  @article{ , abstract = {MicroRNAs (miRNAs) are associated with amyloid-β (Aβ) dysmetabolism, a pivotal factor in the pathogenesis of Alzheimer's disease (AD). This study unveiled a novel miRNA, microRNA-32533 (miR-32533), featuring a distinctive base sequence identified through RNA sequencing of the APPswe/PSEN1dE9 (APP/PS1) mouse brain. Its role and underlying mechanisms were subsequently explored. Bioinformatics and confirmatory experiments revealed that miR-32533 had a novel 23-base sequence with minimal coding potential, functioning within the Drosha ribonuclease III (Drosha)/Dicer 1, ribonuclease III (Dicer)-dependent canonical pathway and identifiable via northern blot. miR-32533 was abundantly brain-distributed and downregulated in diverse AD-related models, including APP/PS1 and five familial AD (5×FAD) mouse brains and AD patient plasma. Overexpression or inhibition of miR-32533 led to improvements or exacerbations in cognitive dysfunction, respectively, by modulating Aβ production, apoptosis, oxidation, and neuroinflammation through targeting cAMP-responsive element binding protein 5 (CREB5), which interacted with α disintegrin and metalloproteinase 10 (ADAM10), beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), and presenilin 1 (PS1) promoters, thereby enhancing Aβ production through BACE1 and PS1 upregulation while suppressing non-amyloidogenic amyloid precursor protein (APP) processing via ADAM10 downregulation. Furthermore, modulation of the miR-32533/CREB5 axis ameliorated or worsened cognitive impairment by inhibiting or amplifying Aβ overproduction through the BACE1-involved amyloidogenic and ADAM10-involved non-amyloidogenic pathways. Overall, the findings suggest miR-32533 as a regulator of Aβ metabolism, oxidative stress, and neuroinflammation, establishing the miR-32533/CREB5 signaling pathways as potential therapeutic targets for combating Aβ accumulation and cognitive deficits in AD.}, archive = {J_ADVS}, author = {Li Zeng and Zhongdi Cai and Jianghong Liu and Kaiyue Zhao and Furu Liang and Ting Sun and Zhuorong Li and Rui Liu}, doi = {10.1002/advs.202409986}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409986}, shortjournal = {Adv. Sci.}, title = {MiR-32533 reduces cognitive impairment and amyloid-β overload by targeting CREB5-mediated signaling pathways in alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). 3D-printed myocardium-specific structure enhances maturation and therapeutic efficacy of engineered heart tissue in myocardial infarction. ADVS, 12(10), 2409871. (www)

  @article{ , abstract = {Despite advancements in engineered heart tissue (EHT), challenges persist in achieving accurate dimensional accuracy of scaffolds and maturing human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), a primary source of functional cardiac cells. Drawing inspiration from cardiac muscle fiber arrangement, a three-dimensional (3D)-printed multi-layered microporous polycaprolactone (PCL) scaffold is created with interlayer angles set at 45° to replicate the precise structure of native cardiac tissue. Compared with the control group and 90° PCL scaffolds, the 45° PCL scaffolds exhibited superior biocompatibility for cell culture and improved hiPSC-CM maturation in calcium handling. RNA sequencing demonstrated that the 45° PCL scaffold promotes the mature phenotype in hiPSC-CMs by upregulating ion channel genes. Using the 45° PCL scaffold, a multi-cellular EHT is successfully constructed, incorporating human cardiomyocytes, endothelial cells, and mesenchymal stem cells. These complex EHTs significantly enhanced hiPSC-CM engraftment in vivo, attenuated ventricular remodeling, and improved cardiac function in mouse myocardial infarction. In summary, the myocardium-specific structured EHT developed in this study represents a promising advancement in cardiovascular regenerative medicine.}, archive = {J_ADVS}, author = {Yong Wu and Yaning Wang and Miao Xiao and Guangming Zhang and Feixiang Zhang and Mingliang Tang and Wei Lei and Ziyun Jiang and Xiaoyun Li and Huiqi Zhang and Xiaoyi Ren and Yue Xu and Xiaotong Zhao and Chenxu Guo and Hongbo Lan and Zhenya Shen and Jianyi Zhang and Shijun Hu}, doi = {10.1002/advs.202409871}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409871}, shortjournal = {Adv. Sci.}, title = {3D-printed myocardium-specific structure enhances maturation and therapeutic efficacy of engineered heart tissue in myocardial infarction}, volume = {12}, year = {2025}, }
• (2025). Biomaterial surface-mediated macrophages exert immunomodulatory roles by exosomal CCL2-induced membrane integrin β1 trafficking in recipient cells. ADVS, 12(10), 2409809. (www)

  @article{ , abstract = {The interaction between biomaterials and immune system is a critical area of research, especially in tissue engineering and regenerative medicine. A fascinating and less explored aspect involves the immunomodulatory behaviors of macrophage (MΦ)-derived exosomes induced by biomaterial surfaces. Herein, untreated surface, nanostructured surface, and type I collagen (Col-I)-decorated nanostructured surface of titanium implants are chosen to culture MΦs, followed by extraction of MΦ-derived exosomes and investigation of their immunomodulatory functions and mechanisms. The results show that the exosomes in the untreated group carried plenty of inflammatory cytokines, predominantly C ─ C motif chemokine ligand 2 (CCL2). After targeting recipient cells, the CCL2 on the exosomes can specifically bind to its receptor C ─ C motif chemokine receptor 2, triggering downstream signaling pathways to induce internalization of membrane integrin β1 and targeted lysosomal degradation, consequently suppressing the functions of recipient cells. In contrast, the exosomes in the nanostructured group, especially Col-I-decorated nanostructured group carried few CCL2, moderating their inhibition on the functions of recipient cells. These findings not only clearly show that CCL2 is a key constituent of exosomes involved in the interaction between biomaterials and host immune system, but also potentially a key target for designing advanced biomaterials to promote tissue repair and regeneration.}, archive = {J_ADVS}, author = {Yuyu Zhao and Ruiyue Hang and Huifei Li and Yonghua Sun and Runhua Yao and Xiaobo Huang and Xiangyu Zhang and Xiaohong Yao and Huaiyu Wang and Yin Xiao and Di Huang and Yong Han and Xing Wang and Ruiqiang Hang}, doi = {10.1002/advs.202409809}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409809}, shortjournal = {Adv. Sci.}, title = {Biomaterial surface-mediated macrophages exert immunomodulatory roles by exosomal CCL2-induced membrane integrin β1 trafficking in recipient cells}, volume = {12}, year = {2025}, }
• (2025). Novel leech antimicrobial peptides, hirunipins: Real-time 3D monitoring of antimicrobial and antibiofilm mechanisms using optical diffraction tomography. ADVS, 12(10), 2409803. (www)

  @article{ , abstract = {Antimicrobial peptides (AMPs) are promising agents for treating antibiotic-resistant bacterial infections. Although discovering novel AMPs is crucial for combating multidrug-resistant bacteria and biofilm-related infections, their clinical potential relies on precise, real-time evaluation of efficacy, toxicity, and mechanisms. Optical diffraction tomography (ODT), a label-free imaging technology, enables real-time visualization of bacterial morphological changes, membrane damage, and biofilm formation over time. Here, a computational analysis of the leech transcriptome using an advanced AI-based peptide screening strategy with ODT to identify potential AMPs is employed. Among the 19 potential AMPs identified, hirunipin 2 demonstrates potent antibacterial activity, low mammalian cytotoxicity, and minimal hemolytic effects. It demonstrates efficacy comparable to melittin, resistance to physiological salts and human serum, and a low likelihood of inducing bacterial resistance. Microscopy and 3D-ODT confirm its disruption of bacterial membranes and intracellular aggregation, leading to cell death. Notably, hirunipin 2 effectively inhibits biofilm formation, eradicates preformed biofilms, and synergizes with antibiotics against multidrug-resistant Acinetobacter baumannii (MDRAB) by enhancing membrane permeability. Additionally, hirunipin 2 significantly suppresses pro-inflammatory cytokine expression in LPS-stimulated macrophages, highlighting its anti-inflammatory properties. These findings highlight hirunipin 2 as a strong candidate for developing novel antibacterial, anti-inflammatory, and antibiofilm therapies, particularly against multidrug-resistant bacterial infections.}, archive = {J_ADVS}, author = {S. Dinesh Kumar and Jeongwon Park and Naveen Kumar Radhakrishnan and Yam Prasad Aryal and Geon-Hwi Jeong and In-Hyeok Pyo and Byambasuren Ganbaatar and Chul Won Lee and Sungtae Yang and Younhee Shin and Sathiyamoorthy Subramaniyam and Yu-jin Lim and Sung-Hak Kim and Seongsoo Lee and Song Yub Shin and Sung-Jin Cho}, doi = {10.1002/advs.202409803}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409803}, shortjournal = {Adv. Sci.}, title = {Novel leech antimicrobial peptides, hirunipins: Real-time 3D monitoring of antimicrobial and antibiofilm mechanisms using optical diffraction tomography}, volume = {12}, year = {2025}, }
• (2025). Programmed transformation of osteogenesis microenvironment by a multifunctional hydrogel to enhance repair of infectious bone defects. ADVS, 12(10), 2409683. (www)

  @article{ , abstract = {Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk of infection and excessive reactive oxygen species (ROS) during the early stage, and the residual bacteria and delayed Osseo integrated interface in the later stage, which jointly creates a complex and dynamic microenvironment and leads to bone non-union. The melatonin carbon dots (MCDs) possess antibacterial and osteogenesis abilities, greatly simplifying the composition of a multifunctional material. Therefore, a multifunctional hydrogel containing MCDs (GH-MCD) is developed to meet the multi-stage and complex repair needs of infectious bone injury in this study. The GH-MCD can intelligently release MCDs responding to the acidic microenvironment to scavenge intracellular ROS and exhibit good antibacterial activity by inducing the production of ROS in bacteria and inhibiting the expression of secA2 . Moreover, it has high osteogenesis and long-lasting antimicrobial activity during bone repair. RNA-seq results reveal that the hydrogels promote the repair of infected bone healing by enhancing cellular resistance to bacteria, balancing osteogenesis and osteoclastogenesis, and regulating the immune microenvironment. In conclusion, the GH-MCD can promote the repair of infectious bone defects through the programmed transformation of the microenvironment, providing a novel strategy for infectious bone defects.}, archive = {J_ADVS}, author = {En Xie and Zhangqin Yuan and Qianglong Chen and Jie Hu and Jiaying Li and Kexin Li and Huan Wang and Jinjin Ma and Bin Meng and Ruoxi Zhang and Haijiao Mao and Ting Liang and Lijie Wang and Chaoyong Liu and Bin Li and Fengxuan Han}, doi = {10.1002/advs.202409683}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409683}, shortjournal = {Adv. Sci.}, title = {Programmed transformation of osteogenesis microenvironment by a multifunctional hydrogel to enhance repair of infectious bone defects}, volume = {12}, year = {2025}, }
• (2025). Youthful stem cell microenvironments: Rejuvenating aged bone repair through mitochondrial homeostasis remodeling. ADVS, 12(10), 2409644. (www)

  @article{ , abstract = {Extracellular matrix (ECM) derived from mesenchymal stem cells regulates antioxidant properties and bone metabolism by providing a favorable extracellular microenvironment. However, its functional role and molecular mechanism in mitochondrial function regulation and aged bone regeneration remain insufficiently elucidated. This proteomic analysis has revealed a greater abundance of proteins supporting mitochondrial function in the young ECM (Y-ECM) secreted by young bone marrow-derived mesenchymal stem cells (BMMSCs) compared to the aged ECM (A-ECM). Further studies demonstrate that Y-ECM significantly rejuvenates mitochondrial energy metabolism in adult BMMSCs (A-BMMSCs) through the promotion of mitochondrial respiratory functions and amelioration of oxidative stress. A-BMMSCs cultured on Y-ECM exhibited enhanced multi-lineage differentiation potentials in vitro and ectopic bone formation in vivo. Mechanistically, silencing of silent information regulator type 3 (SIRT3) gene abolished the protective impact of Y-ECM on A-BMMSCs. Notably, a novel composite biomaterial combining hyaluronic acid methacrylate hydrogel microspheres with Y-ECM is developed, which yielded substantial improvements in the healing of bone defects in an aged rat model. Collectively, these findings underscore the pivotal role of Y-ECM in maintaining mitochondrial redox homeostasis and present a promising therapeutic strategy for the repair of aged bone defects.}, archive = {J_ADVS}, author = {Xinfeng Zhou and Xin Tian and Jianan Chen and Yantong Li and Nanning Lv and Hao Liu and Tao Liu and Huilin Yang and Xi Chen and Yong Xu and Fan He}, doi = {10.1002/advs.202409644}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409644}, shortjournal = {Adv. Sci.}, title = {Youthful stem cell microenvironments: Rejuvenating aged bone repair through mitochondrial homeostasis remodeling}, volume = {12}, year = {2025}, }
• (2025). ℤ-classified topological phases and bound states in the continuum induced by multiple orbitals. ADVS, 12(10), 2409574. (www)

  @article{ , abstract = {ℤ- classified higher-order topological insulators (HOTIs) with chiral-symmetric higher-order topological phases protected by multipole chiral numbers (MCNs) have attracted extensive interest recently. However, how to design artificial ℤ-classified HOTIs with multiple topological phases remains an unresolved issue. Here, multiorbital degrees of freedom are introduced to acoustic crystals and the various methods of topological phase transitions are achieved for the orbital ℤ-classified HOTIs. Experimental results demonstrate the realization the coexistence of corner modes with distinct mechanisms within one single model. This provides a pathway for finding ℤ-classified with large MCNs independent of long-range coupling. Additionally, a universal approach is introduced here to fabricate topological bound states in the continuum derived from the discrepant onsite energy of degenerate p -orbitals. These findings provide new insights into the study of topological wave physics using orbital degrees of freedom and may pave the way for designing innovative orbital topological devices for sensing and computing.}, archive = {J_ADVS}, author = {Shi-Feng Li and Wen-Jie Yang and Cui-Yu-Yang Zhou and Yi-Fan Zhu and Xin-Ye Zou and Jian-Chun Cheng and Badreddine Assouar}, doi = {10.1002/advs.202409574}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409574}, shortjournal = {Adv. Sci.}, title = {ℤ-classified topological phases and bound states in the continuum induced by multiple orbitals}, volume = {12}, year = {2025}, }
• (2025). CAMKIIδ reinforces lipid metabolism and promotes the development of b cell lymphoma. ADVS, 12(10), 2409513. (www)

  @article{ , abstract = {The most prevalent types of lymphomas are B cell lymphomas (BCL). Newer therapies for BCL have improved the prognosis for many patients. However, approximately 30% with aggressive BCL either remain refractory or ultimately relapse. These patients urgently need other options. This study shows how calcium/calmodulin-dependent protein kinase II delta (CAMKIIδ) is pivotal for BCL development. In BCL cells, ablation of CAMKIIδ inhibits both lipolysis from lipid droplets and oxidative phosphorylation (OXPHOS). With lipolysis blocked, BCL progression is markedly suppressed in two distinct BCL mouse models: MYC-driven EµMyc mice and Myc/Bcl2 double-expressed mice. When CAMKIIδ is present, it destabilizes transcription factor Forkhead Box O3A (FOXO3A) by phosphorylating it at Ser7 and Ser12. This then permits transcription of downstream gene IRF4 – a master transcription factor of lipid metabolism. The CAMKIIδ/FOXO3A axis bolsters lipid metabolism, mitochondrial respiration, and tumor fitness in BCL under metabolic stress. This study also evaluates Tetrandrine (TET), a small molecule compound, as a potent CAMKIIδ inhibitor. TET attenuates metabolic fitness and elicits therapeutic responses both in vitro and in vivo. Collectively, this study highlights how CAMKIIδ is critical in BCL progression. The results also pave the way for innovative therapeutic strategies for treating aggressive BCL.}, archive = {J_ADVS}, author = {Jiawei Zhang and Senlin Xu and Hui Fang and Dehao Wu and Ching Ouyang and Yunfei Shi and Zhenkang Hu and Mingfeng Zhang and Yaoyao Zhong and Junwei Zhao and Yichao Gan and Shize Zhang and Xiaoqian Liu and Jie Yin and Yuan Li and Mengyue Tang and Yingda Wang and Ling Li and Wing C Chan and David Horne and Mingye Feng and Wendong Huang and Ying Gu}, doi = {10.1002/advs.202409513}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409513}, shortjournal = {Adv. Sci.}, title = {CAMKIIδ reinforces lipid metabolism and promotes the development of b cell lymphoma}, volume = {12}, year = {2025}, }
• (2025). Perfluorohexane sulfonic acid disrupts the immune microenvironment for spermatogenesis by damaging the structure of the blood-testis barrier in mice. ADVS, 12(10), 2409383. (www)

  @article{ , abstract = {Perfluorohexane sulfonic acid (PFHxS) is extensively used in waterproof coatings and fire-fighting foams, and several studies have found it to be a potential health hazard, but there is still unknown about its effects on spermatogenesis. Our results showed that PFHxS-treated mice have significant reproductive toxicity, including a decrease in sperm count and motility, and the levels of sex hormones ( P < 0.05). Concurrently, structural abnormalities are observed in sperm, affecting ≈60–75% of those in the PFHxS-treated group. Additionally, it is found that the structure of the blood-testis barrier (BTB) is damaged after PFHxS treatment, leading to higher expression levels of inflammatory cytokines in the microenvironment for spermatogenesis. Moreover, the expression of proteins associated with mitochondrial biogenesis, including PTEN-induced kinase 1 (PINK1) and NADPH oxidase 4 (NOX4), is dysregulated in the testes after PFHxS treatment. Based on metabolome data, the differential metabolite 3-hydroxybutanoic acid is identified in the PFHxS-treated group, which can regulate the histone Kac levels, especially H3K4ac and H3K9ac. In summary, the results of this study suggest that in the testes of PFHxS-treated mice, inflammatory factors disrupt the mitochondrial function and metabolic profiles and hinder the progress of gene transcription through histone Kac, ultimately causing sperm dysfunction.}, archive = {J_ADVS}, author = {Yan Zhang and Mingxue Shu and Shilin Shan and Huiying Liu and Yucheng Zhang and Chenyang Song and Qiaoqiao Xu and Yun Fan and Chuncheng Lu}, doi = {10.1002/advs.202409383}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409383}, shortjournal = {Adv. Sci.}, title = {Perfluorohexane sulfonic acid disrupts the immune microenvironment for spermatogenesis by damaging the structure of the blood-testis barrier in mice}, volume = {12}, year = {2025}, }
• (2025). Tape-assisted residual layer-free one-step nanoimprinting of high-index hybrid polymer for optical loss-suppressed metasurfaces. ADVS, 12(10), 2409371. (www)

  @article{ , abstract = {The commercialization of metasurfaces is crucial for real-world applications such as wearable sensors, pigment-free color pixels, and augmented and virtual reality devices. Nanoparticle-embedded resin-based nanoimprint lithography (PER-NIL) has shown itself to be a low-cost, high-throughput manufacturing method enabling the replication of high-index nanostructures. It has been extensively integrated into the fabrication of hologram metasurfaces, metalenses, and sensors due to its procedural simplicity. Most research on PER-NIL has been limited to exploring appropriate materials to enhance the efficiency of imprinted metasurfaces, but the intrinsic issue of PER-NIL lies in the high-index residual layer remaining on the substrate. This high-index residual layer generates undesired noise, limiting the efficiency and functionality of imprinted metasurfaces. Despite the need for the removal of the residual layer, it has never been experimentally achieved owing to the different etching rates between the nanoparticles and resin. Here, a new methodology named tape-assisted PER-NIL is proposed, achieving one-step removal of the residual layer using a tape. This novel method enables the replication of residual layer-free, high-index metasurfaces. As a result, imprinted residual layer-free metasurfaces prove their potential in high-purity dielectric structural colorations by achieving a sharp reflectance peak unattainable with conventional NIL, and in vivid hologram metasurfaces by covering a full 2π phase without unwanted scattering.}, archive = {J_ADVS}, author = {Yujin Park and Joohoon Kim and Younghwan Yang and Dong Kyo Oh and Hyunjung Kang and Hongyoon Kim and Junsuk Rho}, doi = {10.1002/advs.202409371}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409371}, shortjournal = {Adv. Sci.}, title = {Tape-assisted residual layer-free one-step nanoimprinting of high-index hybrid polymer for optical loss-suppressed metasurfaces}, volume = {12}, year = {2025}, }
• (2025). A novel 167-amino acid protein encoded by CircPCSK6 inhibits intrahepatic cholangiocarcinoma progression via IKBα ubiquitination. ADVS, 12(10), 2409173. (www)

  @article{ , abstract = {Intrahepatic cholangiocarcinoma (ICC), a formidable challenge in oncology, demands innovative biomarkers and therapeutic targets. This research highlights the importance of the circular RNA (circRNA) circPCSK6 and its peptide derivative circPCSK6-167aa in ICC. CircPCSK6 is significantly downregulated in both ICC patients and mouse primary ICC models, and its lower expression is linked to adverse prognosis, highlighting its pivotal role in ICC pathogenesis. Functionally, this study elucidates the regulatory effect of circPCSK6-167aa on IκBα ubiquitination within the NF-κB pathway, which is mediated by its competitive binding to the E3 ligase RBBP6. This complex interaction leads to reduced activation of the NF-κB pathway, thereby curbing tumor cell proliferation, migration, invasion, stemness, and hepatic-lung metastasis in vivo. This groundbreaking discovery expands the understanding of circRNA-driven tumorigenesis through atypical signaling pathways. Additionally, this investigation identified EIF4A3 as a detrimental regulator of circPCSK6, exacerbating ICC malignancy. Importantly, by leveraging patient-derived xenograft (PDX), organoids, and organoid-derived PDX models, higher levels of circPCSK6-167aa enhance sensitivity to gemcitabine, indicating its potential to improve the effectiveness of chemotherapy. These insights emphasize the therapeutic promise of targeting circPCSK6-167aa, offering vital biological insights and clinical directions for developing cutting-edge therapeutic approaches, thus revealing innovative strategies and targets for future treatments.}, archive = {J_ADVS}, author = {Canghai Guan and Jianjun Gao and Xinlei Zou and Wujiang Shi and Yunhe Hao and Yifei Ge and Zhaoqiang Xu and Chengru Yang and Shaowu Bi and Xingming Jiang and Pengcheng Kang and Xiaoxue Xu and Xiangyu Zhong}, doi = {10.1002/advs.202409173}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409173}, shortjournal = {Adv. Sci.}, title = {A novel 167-amino acid protein encoded by CircPCSK6 inhibits intrahepatic cholangiocarcinoma progression via IKBα ubiquitination}, volume = {12}, year = {2025}, }
• (2025). Intratumoral collagen deposition supports angiogenesis suggesting anti-angiogenic therapy in armored and cold tumors. ADVS, 12(10), 2409147. (www)

  @article{ , abstract = {A previous study classifies solid tumors based on collagen deposition and immune infiltration abundance, identifying a refractory subtype termed armored & cold tumors, characterized by elevated collagen deposition and diminished immune infiltration. Beyond its impact on immune infiltration, collagen deposition also influences tumor angiogenesis. This study systematically analyzes the association between immuno-collagenic subtypes and angiogenesis across diverse cancer types. As a result, armored & cold tumors exhibit the highest angiogenic activity in lung adenocarcinoma (LUAD). Single-cell and spatial transcriptomics reveal close interactions and spatial co-localization of fibroblasts and endothelial cells. In vitro experiments demonstrate that collagen stimulates tumor cells to express vascular endothelial growth factor A (VEGFA) and directly enhances vessel formation and endothelial cell proliferation through sex determining region Y box 18 (SOX18) upregulation. Collagen inhibition via multiple approaches effectively suppresses tumor angiogenesis in vivo. In addition, armored & cold tumors display superior responsiveness to anti-angiogenic therapy in advanced LUAD cohorts. Post-immunotherapy resistance, the transformation into armored & cold tumors emerges as a potential biomarker for selecting anti-angiogenic therapy. In summary, collagen deposition is shown to drive angiogenesis across various cancers, providing a novel and actionable framework to refine therapeutic strategies combining chemotherapy with anti-angiogenic treatments.}, archive = {J_ADVS}, author = {Jie Mei and Kai Yang and Xinkang Zhang and Zhiwen Luo and Min Tian and Hanfang Fan and Jiahui Chu and Yan Zhang and Junli Ding and Junying Xu and Yun Cai and Yongmei Yin}, doi = {10.1002/advs.202409147}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2409147}, shortjournal = {Adv. Sci.}, title = {Intratumoral collagen deposition supports angiogenesis suggesting anti-angiogenic therapy in armored and cold tumors}, volume = {12}, year = {2025}, }
• (2025). Enhancing RT-PCR throughput and sensitivity through large-scale sample pooling using a nano-hybrid membrane. ADVS, 12(10), 2408771. (www)

  @article{ , abstract = {During the pandemic surge, including SARS-CoV-2 and influenza, pooling samples emerged as an efficient strategy to identify infected individuals in large groups. While pooling enhances RT-PCR throughput, reducing costs and resources, it dilutes positive samples with negative ones, lowering sensitivity and increasing false negatives. This study proposes a new method to address the trade-off between pool sizes and RT-PCR accuracy. This method integrates large-scale pooling with sample enrichment using a nano-hybrid membrane, preventing the pooling-induced decrease in viral concentration and maintaining cycle threshold (Ct) values close to individual positive samples. The nano-hybrid membrane, named SIMPLE (streamlined, simple, and inexpensive method for preconcentration, lysis, and nucleic acid extraction), comprises layered red blood cell membranes, polyethersulfone, and silica membranes. Using SIMPLE, a Ct value reduction to ≈2.6 is demonstrated in pooled COVID-19 samples with a pool size of 6 and found Ct values from larger pool sizes (8, 16, 32, 64, and 128) comparable to individual positive samples.}, archive = {J_ADVS}, author = {Na Eun Lee and Kang Hyeon Kim and Ji Hye Hong and Seungmin Lee and Jeong Soo Park and Dohwan Lee and Dae Sung Yoon and Jeong Hoon Lee}, doi = {10.1002/advs.202408771}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2408771}, shortjournal = {Adv. Sci.}, title = {Enhancing RT-PCR throughput and sensitivity through large-scale sample pooling using a nano-hybrid membrane}, volume = {12}, year = {2025}, }
• (2025). MLLT3 regulates melanoma stemness and progression by inhibiting HMGB1 nuclear entry and MAGEA1 M5C modification. ADVS, 12(10), 2408529. (www)

  @article{ , abstract = {Melanoma stem cells are a kind of cells with self-renewal and multi-directional differentiation potential. They are one of the key factors in the occurrence, development and metastasis of melanoma. This study demonstrates that MLLT3 is a transcription factor that regulates the stemness and progression of melanoma. MLLT3 interacted with HMGB1 to inhibit its entry into the nucleus, MLLT3 interacted with YBX1 to inhibit its reading of m 5 C of MAGEA1 , thereby inhibiting the mRNA stability of MAGEA1 , and directly transcribed P53 to inhibit the stemness, proliferation and metastasis of melanoma cells. This study further explored the potential mechanism of the interaction between miR-542-3p/miR-3922-3p and MLLT3 . Furthermore, the scRNA-seq of melanoma cells with MLLT3 knock-out resulted in important changes in cell subsets, activating the TP53 and MAPK pathways and transforming into stem cells. The results indicate that the transcription factor MLLT3 is a suppressor gene that regulates the stemness and progression of melanoma, and is expected to become a target for melanoma therapy.}, archive = {J_ADVS}, author = {Yaling Li and Hong Liu and Jingyi Li and Chang Fu and Bin Jiang and Bancheng Chen and Yanfen Zou and Bo Yu and Bing Song}, doi = {10.1002/advs.202408529}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2408529}, shortjournal = {Adv. Sci.}, title = {MLLT3 regulates melanoma stemness and progression by inhibiting HMGB1 nuclear entry and MAGEA1 M5C modification}, volume = {12}, year = {2025}, }
• (2025). Artificial intelligence for predicting HER2 status of gastric cancer based on whole-slide histopathology images: A retrospective multicenter study. ADVS, 12(10), 2408451. (www)

  @article{ , abstract = {Human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC) shows a robust response to the combined therapy based HER2-targeted therapy. The application of these therapies is highly dependent on the evaluation of tumor HER2 status. However, there are many risks and challenges in HER2 assessment in GC. Therefore, an economically viable and readily available instrument is requisite for distinguishing HER2 status among patients diagnosed with GC. The study has innovatively developed a deep learning model, HER2Net, which can predict the HER2 status by quantitatively calculating the proportion of HER2 high-expression regions. The HER2Net is trained on an internal training set derived from 531 hematoxylin & eosin (H&E) whole slide images (WSI) of 520 patients. Subsequently, the performance of HER2Net is validated on an internal test set from 115 H&E WSI of 111 patients and an external multi-center test set from 102 H&E WSI of 101 patients. The HER2Net achieves an accuracy of 0.9043 on the internal test set, and an accuracy of 0.8922 on an external test set from multiple institutes. This discovery indicates that the HER2Net can potentially offer a novel methodology for the identification of HER2-positive GC.}, archive = {J_ADVS}, author = {Yuhan Liao and Xinhua Chen and Shupeng Hu and Bing Chen and Xinghua Zhuo and Hao Xu and Xiaojin Wu and Xiaofeng Zeng and Huimin Zeng and Donghui Zhang and Yunfei Zhi and Liang Zhao}, doi = {10.1002/advs.202408451}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2408451}, shortjournal = {Adv. Sci.}, title = {Artificial intelligence for predicting HER2 status of gastric cancer based on whole-slide histopathology images: A retrospective multicenter study}, volume = {12}, year = {2025}, }
• (2025). Observation of extraordinary vibration scatterings induced by strong anharmonicity in lead-free halide double perovskites. ADVS, 12(10), 2408149. (www)

  @article{ , abstract = {Lead-free halide double perovskites provide a promising solution for the long-standing issues of lead-containing halide perovskites, i.e., the toxicity of Pb and the low stability under ambient conditions and high-intensity illumination. Their light-to-electricity or thermal-to-electricity conversion is strongly determined by the dynamics of the corresponding lattice vibrations. Here, the measurement of lattice dynamics is presented in a prototypical lead-free halide double perovskite(Cs 2 NaInCl 6 ). The quantitative measurements and first-principles calculations show that the scatterings among lattice vibrations at room temperature are at the timescale of ≈1 ps, which stems from the extraordinarily strong anharmonicity in Cs 2 NaInCl 6 . Further the degree of anharmonicity of each type of atom is quantitatively characterized in the Cs 2 NaInCl 6 single crystal, which stems from the interatomic forces, and demonstrate that this strong anharmonicity is synergistically contributed by the bond hierarchy, the tilting of the NaCl 6 and InCl 6 octahedral units, and the rattling of Cs + ions. Consequently, the crystalline Cs 2 NaInCl 6 possesses an ultralow thermal conductivity of ≈0.43 W mK −1 at room temperature, and a weak temperature dependence of T −0.41 . These findings uncovered the underlying mechanisms behind the dynamics of lattice vibrations in double perovskites, which can largely benefit the design of optoelectronics and thermoelectrics based on halide double perovskites.}, archive = {J_ADVS}, author = {Guang Wang and Jiongzhi Zheng and Jie Xue and Yixin Xu and Qiye Zheng and Geoffroy Hautier and Haipeng Lu and Yanguang Zhou}, doi = {10.1002/advs.202408149}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2408149}, shortjournal = {Adv. Sci.}, title = {Observation of extraordinary vibration scatterings induced by strong anharmonicity in lead-free halide double perovskites}, volume = {12}, year = {2025}, }
• (2025). L-aspartic acid with dual functions: An eco-friendly and affordable choice to accelerate high salinity brine utilization. ADVS, 12(10), 2408081. (www)

  @article{ , abstract = {L-Aspartic acid (L-Asp) poses a dual function, which can affect the evaporation and crystallization process of the high-salinity brine by altering the physical or chemical properties of the salts. MSWI (municipal solid waste incineration) fly ash washing leachate, as a typical high-salinity brine, is utilized here to validate this hypothesis under the simulation guidance. Since L-Asp has stronger adsorption energy on the (110) crystal face of CaCO 3 , L-Asp can facilitate the preferential growth of more valuable vaterite during the softening process (pretreatment before crystallization). Subsequently, the resulting solution undergoes a stable interfacial solar-driven crystallization process under the L-Asp, with a high salt recovery ratio of 0.14 kg m −2 h −1 within 40 h under 1 sun. Finally, to harness the “cradle to grave” full life cycle utilization of washing leachate, the extracted mixed salts are utilized for moisture-enabled electricity generation. L-Asp can significantly enhance this process by reducing the critical relative humidity of mixed salts, thereby exhibiting a stable open circuit potential and short-cut current of ≈ 0.51 V and 10.6 µA within continuous 800 min. In conclusion, this work not only provides innovative approaches for upcycling high-salinity wastewater but also explores novel applications for L-Asp.}, archive = {J_ADVS}, author = {Suning Mao and Zhen Yu and Jie Chen and Yizhe Shen and Minjie Li and Chen Sun and Xiaoqing Lin and Bin Yang and Tong Chen and Qunxing Huang and Xiaodong Li and Jianhua Yan}, doi = {10.1002/advs.202408081}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2408081}, shortjournal = {Adv. Sci.}, title = {L-aspartic acid with dual functions: An eco-friendly and affordable choice to accelerate high salinity brine utilization}, volume = {12}, year = {2025}, }
• (2025). HACD2 promotes pancreatic cancer progression by enhancing PKM2 dissociation from PRKN in a dehydratase-independent manner. ADVS, 12(10), 2407942. (www)

  @article{ , abstract = {3-Hydroxyacyl-CoA dehydratase 2 (HACD2), an obesity-related gene involved in the elongation of long-chain fatty acids, is highly expressed in pancreatic cancer (PC) and is associated with patient prognosis. Interestingly, the study reveals that HACD2 mediated the proliferation of PC cells in a dehydratase-independent manner, affecting the downstream glycolytic pathway. Mechanistically, HACD2 promotes PC cells proliferation by binding to E3 ubiquitin-protein ligase parkin (PRKN) and enhancing pyruvate kinase PKM (PKM2) dissociation from PRKN, resulting in reduced ubiquitination of PKM2 and increased dimerization of PKM2, which subsequently promote c-Myc expression and tumor growth. Moreover, HACD2 overexpression-induced PC growth is mitigated by knockdown of PKM2 or overexpression of PRKN. Furthermore, the weight loss drug orlistat, which potentially binds to HACD2, disrupted the interaction between HACD2 and PRKN and further increased the ubiquitination of PKM2. Therefore, this study elucidates the mechanism by which the obesity-related gene HACD2 regulates PC cells proliferation through a noncanonical signaling pathway, which may provide a potential new target and strategy for the individualized clinical treatment of PC.}, archive = {J_ADVS}, author = {Xuanning Chu and Jinyu Zhao and Yuting Shen and Qi Feng and Changlin Zhou and Lingman Ma and Yiran Zhou}, doi = {10.1002/advs.202407942}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2407942}, shortjournal = {Adv. Sci.}, title = {HACD2 promotes pancreatic cancer progression by enhancing PKM2 dissociation from PRKN in a dehydratase-independent manner}, volume = {12}, year = {2025}, }
• (2025). Targeting MAPK14 by lobeline upregulates slurp1-mediated inhibition of alternative activation of TAM and retards colorectal cancer growth. ADVS, 12(10), 2407900. (www)

  @article{ , abstract = {Colorectal cancer (CRC) usually creates an immunosuppressive microenvironment, thereby hindering immunotherapy response. Effective treatment options remain elusive. Using scRNA-seq analysis in a tumor-bearing murine model, it is found that lobeline, an alkaloid from the herbal medicine lobelia, promotes polarization of tumor-associated macrophages (TAMs) toward M1-like TAMs while inhibiting their polarization toward M2-like TAMs. Additionally, lobeline upregulates mRNA expression of secreted Ly-6/UPAR-related protein 1 ( Slurp1 ) in cancer cells. The inhibitory effects of lobeline on tumor load and TAM polarization are almost completely eliminated when Slurp1-deficient MC38 cells are subcutaneously injected into mice, suggesting that lobeline exerts an antitumor effect in a Slurp1-dependent manner. Furthermore, using target-responsive accessibility profiling, MAPK14 is identified as the direct target protein of lobeline. Mechanistically, upon binding to MAPK14 in colon cancer cells, lobeline prevents nuclear translocation of MAPK14, resulting in decreased levels of phosphorylated p53. Consequently, negative transcriptional regulation of SLURP1 by p53 is suppressed, leading to enhanced transcription and secretion of SLURP1. Finally, combination therapy using lobeline and anti-PD1 exhibits stronger antitumor effects. Taken together, these findings suggest that remodeling the immunosuppressive microenvironment using small-molecule lobeline may represent a promising therapeutic strategy for CRC.}, archive = {J_ADVS}, author = {Mingxia Zhao and Lisha Zhou and Qinchang Zhang and Meijing Wang and Yue Dong and Yue Wang and Ruixue Pei and Enguang He and Yanyan Liang and Yujun Shen and Guoliang Deng and Hongqi Chen and Dongdong Sun and Yuxian Shen and Yang Sun and Haibo Cheng}, doi = {10.1002/advs.202407900}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2407900}, shortjournal = {Adv. Sci.}, title = {Targeting MAPK14 by lobeline upregulates slurp1-mediated inhibition of alternative activation of TAM and retards colorectal cancer growth}, volume = {12}, year = {2025}, }
• (2025). Barcoded hybrids of extracellular vesicles and lipid nanoparticles for multiplexed analysis of tissue distribution. ADVS, 12(10), 2407850. (www)

  @article{ , abstract = {Targeted delivery of therapeutic agents is a persistent challenge in modern medicine. Recent efforts in this area have highlighted the utility of extracellular vesicles (EVs) as drug carriers, given that they naturally occur in bloodstream and tissues, and can be loaded with a wide range of therapeutic molecules. However, biodistribution and tissue tropism of EVs remain difficult to study systematically. Here, a multiplexed approach is developed for simultaneous tracking of EVs from various cell lines within a single in vivo experiment. EVs are used from 16 different cell lines, and through controlled fusion with lipid nanoparticles (LNPs) carrying single-stranded DNA barcodes, uniquely barcoded hybrid EV particle (hEV) library is generated. These hEVs are combined for a multiplexed in vivo biodistribution profiling in mice, and discovered that HAP1-derived hEVs demonstrated lung tropism, suggesting that these hEVs may be used for targeted drug delivery into lung tissue. To examine this possibility further, it is shown that HAP1 hEV loaded with Cre mRNA displayed functional delivery to the lungs. Overall, the barcoded hEV technology enables rapid profiling of biodistribution across EV cell sources, which is poised to improve throughput and extent of EV studies, while reducing the number of animals required for research.}, archive = {J_ADVS}, author = {Alena Ivanova and Renata Chalupska and Ana Filipa Louro and Mike Firth and Hernán González-King Garibotti and Leif Hultin and Franziska Kohl and Elisa Lázaro-Ibáñez and Julia Lindgren and Gentian Musa and Erik Oude Blenke and Andreia M. Silva and Louis Szeponik and Agnes Taylor and Ida Viken and Xiaoqin Wang and Karin Jennbacken and John Wiseman and Niek Dekker}, doi = {10.1002/advs.202407850}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2407850}, shortjournal = {Adv. Sci.}, title = {Barcoded hybrids of extracellular vesicles and lipid nanoparticles for multiplexed analysis of tissue distribution}, volume = {12}, year = {2025}, }
• (2025). Extracellular mitochondrial-derived vesicles affect the progression of diabetic foot ulcer by regulating oxidative stress and mitochondrial dysfunction. ADVS, 12(10), 2407574. (www)

  @article{ , abstract = {Diabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus, the etiology of which remains insufficiently understood, particularly regarding the involvement of extracellular vesicles (EVs). In this study, nanoflow cytometry to detect EVs in DFU skin tissues is used and found a significant increase in the Translocase of Outer Mitochondrial Membrane 20 (TOM20) + mitochondrial-derived vesicles (MDVs). The role of MDVs in DFU is yet to be reported. Using single-cell datasets, it is discovered that the increase in MDVs may be regulated by Sorting Nexin 9 (SNX9). In vitro experiments revealed that MDVs secreted by fibroblasts cultured in high glucose medium exhibited similar composition and protein enrichment results to those in DFU tissues, suggesting their potential as an ideal in vitro surrogate. These MDVs promoted apoptosis and intracellular oxidative stress, disrupted mitochondrial structure, and reduced aerobic metabolism in target cells. In vivo experiments also showed that MDV drops hindered wound healing in diabetic mice; however, this effect is rescued by SNX9 inhibitors, restoring mitochondrial dynamics and balance. Under high glucose conditions, MDVs significantly upregulated oxidative stress levels and induced mitochondrial dysfunction. This study proposes targeting MDVs as a potential therapeutic strategy for DFU.}, archive = {J_ADVS}, author = {Huihui Zhang and Zi Yan and Junyou Zhu and Ziyue Li and Lianglong Chen and Weihan Zheng and Zhenning Dai and Jiaxin Yang and Xinyi Yun and Yilin Wang and Hai Zhou and Ziwei Jiang and Qiuyi Yu and Shiyu Li and Wenhua Huang and Lei Yang}, doi = {10.1002/advs.202407574}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2407574}, shortjournal = {Adv. Sci.}, title = {Extracellular mitochondrial-derived vesicles affect the progression of diabetic foot ulcer by regulating oxidative stress and mitochondrial dysfunction}, volume = {12}, year = {2025}, }
• (2025). Dual targeting biomimetic carrier-free nanosystems for photo-chemotherapy of rheumatoid arthritis via macrophage apoptosis and re-polarization. ADVS, 12(10), 2406877. (www)

  @article{ , abstract = {Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease that often results in irreversible joint erosion and disability. Methotrexate (MTX) is the first-line drug against RA, but the significant side effects of long-term administration limit its use. Therefore, new therapeutic strategies are needed for treating RA. Here, dual-targeting biomimetic carrier-free nanomaterials (BSA-MTX-CyI nanosystem, BMC) is developed for synergistic photo-chemotherapy of RA. Bovine serum albumin (BSA), which has high affinity with SPARC (secreted protein acidic and rich in cysteine) in the RA joint microenvironment, is selected as the hydrophilic end and coupled with MTX and the phototherapeutic agent CyI to self-assemble into BMC. In vitro and in vivo experiments revealed that BMC accumulated significantly at the joint site in collagen antibody-induced arthritis mice and could be specifically recognized and taken up by folate receptors in proinflammatory M1 macrophages. Upon near-infrared laser irradiation, CyI exerted photodynamic and photothermal effects, whereas MTX not only inhibited cell proliferation but also increased cell sensitivity to reactive oxygen species, enhancing the apoptotic effect induced by CyI and achieving synergistic photo-chemotherapy. Moreover, BMC could induce macrophages to reprogram into anti-inflammatory M2 macrophages. This study provides innovative approaches for RA treatment via macrophage apoptosis and re-polarization.}, archive = {J_ADVS}, author = {Guanghe Xue and Huimei Jiang and Zhenhua Song and Yifan Zhao and Wen Gao and Bai Lv and Jie Cao}, doi = {10.1002/advs.202406877}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2406877}, shortjournal = {Adv. Sci.}, title = {Dual targeting biomimetic carrier-free nanosystems for photo-chemotherapy of rheumatoid arthritis via macrophage apoptosis and re-polarization}, volume = {12}, year = {2025}, }
• (2025). Nuclear condensates of WW domain-containing adaptor with coiled-coil regulate mitophagy via alternative splicing. ADVS, 12(10), 2406759. (www)

  @article{ , abstract = {Biomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled-coil (WAC) is localized to nuclear speckles via its WW domain and plays a pivotal role in regulating alternative splicing through the formation of biomolecular condensates via its C-terminal coiled-coil (CC) domain. WAC acts as a scaffold protein and facilitates the integration of RNA-binding motif 12 (RBM12) into nuclear speckles, where RBM12 potentially interacts with the spliceosomal U5 small nuclear ribonucleoprotein (snRNP). Importantly, knockdown of RBM12, or deletion of the WAC CC domain led to altered splicing outcomes, resulting in an elevated level of BECN1-S, the short splice variant of BECN1 that is shown to upregulate mitophagy. Thus, the findings reveal a previously unrecognized mechanism for the nuclear regulation of mitochondrial function through liquid–liquid phase separation (LLPS) and provide insights into the pathogenesis of WAC-related disorders.}, archive = {J_ADVS}, author = {Jiahe Wang and Yi Fan and Guowen Luo and Liang Xiong and Lijie Wang and Zhuoxuan Wu and Jiayi Wang and Zhengying Peng and Clifford J Rosen and Kefeng Lu and Junjun Jing and Quan Yuan and Zhenwei Zhang and Chenchen Zhou}, doi = {10.1002/advs.202406759}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2406759}, shortjournal = {Adv. Sci.}, title = {Nuclear condensates of WW domain-containing adaptor with coiled-coil regulate mitophagy via alternative splicing}, volume = {12}, year = {2025}, }
• (2025). The histone lysine demethylase KDM7A contributes to reward memory via fscn1-induced synaptic plasticity in the medial prefrontal cortex. ADVS, 12(10), 2405352. (www)

  @article{ , abstract = {Lysine demethylase 7A (KDM7A) catalyzes the removal of dimethylation from histone H3 lysine 9 and lysine 27, both of which are associated with transcription repression. Previous study indicates that Kdm7a mRNA in the medial prefrontal cortex (mPFC) increases after drug exposure, yet its role in drug-related behaviors is largely unknown. In a morphine-conditioned place preference (CPP) paradigm, these findings reveal a specific increase of Kdm7a expression in the mPFC 7 days after drug withdrawal. Subsequently, these results demonstrate that knockdown of Kdm7a in the mPFC do not affect the acquisition of morphine-induced CPP, but it attenuate memory consolidation. To further explore Kdm7a-mediated transcriptomic changes, this work employs Nanopore direct RNA sequencing. Transcriptome profiling unveils several gene expression alterations impacted by KDM7A, which are enriched in relevant neural function categories. Notably, this work identifies and validates fascin actin-bundling protein 1 (Fscn1) as a downstream molecular target. Knockdown of Fscn1 has a similar impact on CPP to Kdm7a, along with corresponding decrease of dendritic spine density and neuronal activity in the mPFC. Additionally, silencing Kdm7a decreases enrichment of H3K9me2 and H3K27me2 at the Fscn1 promoter region, suggesting that KDM7A may act as a crucial regulator of transcriptional responses to morphine-related reward memory via Fscn1.}, archive = {J_ADVS}, author = {Zhuo-jin Yang and Dong-yu Yu and Fei-fei Gao and Dan-ya Zhou and Ya-nan Wu and Xi-xi Yang and Jie Chen and Jing-si Yang and Meng-qing Shen and Yu-xiang Zhang and Lai Wei and Chun-xia Yan}, doi = {10.1002/advs.202405352}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2405352}, shortjournal = {Adv. Sci.}, title = {The histone lysine demethylase KDM7A contributes to reward memory via fscn1-induced synaptic plasticity in the medial prefrontal cortex}, volume = {12}, year = {2025}, }
• (2025). Genetically programmed single-component protein hydrogel for spinal cord injury repair. ADVS, 12(10), 2405054. (www)

  @article{ , abstract = {Protein self-assembly allows for the formation of diverse supramolecular materials from relatively simple building blocks. In this study, a single-component self-assembling hydrogel is developed using the recombinant protein CsgA, and its successful application for spinal cord injury repair is demonstrated. Gelation is achieved by the physical entanglement of CsgA nanofibrils, resulting in a self-supporting hydrogel at low concentrations (≥5 mg mL −1 ). By leveraging the programmability of the CsgA gene sequence, the bioactive hydrogel is enhanced by fusing functional peptide GHK. GHK is recognized for its anti-inflammatory, antioxidant, and neurotrophic factor-stimulating properties, making it a valuable addition to the hydrogel for spinal cord injury repair applications. In vitro experiments demonstrate that the CsgA-GHK hydrogel can modulate microglial M2 polarization, promote neuronal differentiation of neural stem cells, and inhibit astrocyte differentiation. Additionally, the hydrogel shows efficacy in alleviating inflammation and promotes neuronal regeneration at the injury site, leading to significant functional recovery in a rat model with compression injury spinal cord cavity. These findings lay the groundwork for developing a modular design platform for recombinant CsgA protein hydrogels in tissue repair applications.}, archive = {J_ADVS}, author = {Yi Wei and Xiaolin Zhou and Zhenhua Li and Qing Liu and Han Ding and Yunlong Zhou and Ruo-feng Yin and Lifei Zheng}, doi = {10.1002/advs.202405054}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2405054}, shortjournal = {Adv. Sci.}, title = {Genetically programmed single-component protein hydrogel for spinal cord injury repair}, volume = {12}, year = {2025}, }
• (2025). Humanized candida and NanoBiT assays expedite discovery of bdf1 bromodomain inhibitors with antifungal potential. ADVS, 12(10), 2404260. (www)

  @article{ , abstract = {The fungal Bromodomain and Extra-Terminal (BET) protein Bdf1 is a potential antifungal target against invasive fungal infections. However, the need to selectively inhibit both Bdf1 bromodomains (BDs) over human orthologs and the lack of molecular tools to assess on-target antifungal efficacy hamper efforts to develop Bdf1 BD inhibitors as antifungal therapeutics. This study reports a phenyltriazine compound that inhibits both Bdf1 BDs from the human fungal pathogen Candida glabrata with selectivity over the orthologous BDs from the human BET protein Brd4. On-target antifungal activity is established by devising two yeast-based inhibition assays: a growth assay using humanized Candida strains in which the Bdf1 BDs are replaced by their Brd4 counterparts, and a NanoBiT assay that evaluates the BD-mediated association of Bdf1 with chromatin. These assays additionally enable the discovery that BET inhibitor I-BET726 targets both Bdf1 BDs, inhibits the growth of a broad spectrum of Candida species, including antifungal-resistant clinical isolates, and displays efficacy in an invertebrate animal model of infection. These collective findings highlight the promising potential of Bdf1 BD inhibitors as an innovative class of antifungal therapeutics and the pivotal role of yeast-based assay development toward achieving this end.}, archive = {J_ADVS}, author = {Kaiyao Wei and Marie Arlotto and Justin M. Overhulse and Tuan-Anh Dinh and Yingsheng Zhou and Nathan J. Dupper and Jiayi Yang and Boris A. Kashemirov and Hasan Dawi and Cécile Garnaud and Gaëlle Bourgine and Flore Mietton and Morgane Champleboux and Amédé Larabi and Yordan Hayat and Rose-Laure Indorato and Marjolaine Noirclerc-Savoye and Dimitrios Skoufias and Muriel Cornet and Gwenaël Rabut and Charles E. McKenna and Carlo Petosa and Jérôme Govin}, doi = {10.1002/advs.202404260}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2404260}, shortjournal = {Adv. Sci.}, title = {Humanized candida and NanoBiT assays expedite discovery of bdf1 bromodomain inhibitors with antifungal potential}, volume = {12}, year = {2025}, }
• (2025). CHAC1 mediates endoplasmic reticulum stress-dependent ferroptosis in calcium oxalate kidney stone formation. ADVS, 12(10), 2403992. (www)

  @article{ , abstract = {The initiation of calcium oxalate (CaOx) kidney stone formation is highly likely to stem from injury to the renal tubular epithelial cells (RTECs) induced by stimulation from an aberrant urinary environment. CHAC1 plays a critical role in stress response mechanisms by regulating glutathione metabolism. Endoplasmic reticulum (ER) stress and ferroptosis are demonstrated to be involved in stone formation. This study attempted to elucidate the mechanism of ER stress-dependent ferroptosis and the role of CHAC1 in CaOx kidney stones. Here, regulating ER stress and CHAC1 expression are performed in in vivo and in vitro stone models. These findings indicated that 4-Phenylbutyric acid (4-PBA)treatment and CHAC1 deficiency alleviated the ferroptotic status, including restoring GSH content, suppressing Fe 2+ and lipid peroxidation accumulation, as well as regulating ferroptosis-related proteins. Notably, 4-PBA treatment and CHAC1 deficiency both attenuated oxidative damage, improved renal function, importantly, decreased crystal deposition. Additionally, ChIP-seq and ChIP-qPCR analyses demonstrated that CHAC1 is the vital downstream target gene of ATF4. The results indicated that ATF4 depletion inhibited the upregulation of CHAC1 and pro-ferroptotic response induced by Ox stimulation. Overall, ATF4/CHAC1 axis mediating ER stress-dependent ferroptosis may be a promising research direction for identifying potential strategy to prevent and treat CaOx kidney stones.}, archive = {J_ADVS}, author = {Caitao Dong and Ziqi He and Wenbiao Liao and Qinhong Jiang and Chao Song and Qianlin Song and Xiaozhe Su and Yunhe Xiong and Yunhan Wang and Lingchao Meng and Sixing Yang}, doi = {10.1002/advs.202403992}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2403992}, shortjournal = {Adv. Sci.}, title = {CHAC1 mediates endoplasmic reticulum stress-dependent ferroptosis in calcium oxalate kidney stone formation}, volume = {12}, year = {2025}, }
• (2025). MicroRNA-204-5p deficiency within the vmPFC region contributes to neuroinflammation and behavioral disorders via the JAK2/STAT3 signaling pathway in rats. ADVS, 12(10), 2403080. (www)

  @article{ , abstract = {Major depressive disorder (MDD) is usually considered associate with immune inflammation and synaptic injury within specific brain regions. However, the molecular mechanisms underlying the neural deterioration resulting in depression remain unclear. Here, it is found that miR-204-5p is markedly downregulated in the ventromedial prefrontal cortex (vmPFC) in a chronic unpredictable mild stress (CUMS) induce rat model of depression. Knockdown of miR-204-5p in the vmPFC of normal rats results in depression and anxiety-like behaviors accompanied with the activation of microglia, elevated levels of pro-inflammatory cytokines, and increased numbers of neural apoptotic cells, effects which appear to be mediated by activation of the JAK2/STAT3 signaling pathway. Electrophysiological recordings further demonstrate that knockdown of miR-204-5p induces abnormal excitability of pyramidal neurons. In contrast, upregulation of miR-204-5p in the vmPFC of CUMS rats significantly causes inhibition of JAK2/STAT3 signaling pathway, improvements in neuronal impairments, and an abolition of the depression and anxiety-like behaviors. Moreover, pharmacological blocking of the JAK2/STAT3 signaling pathway significantly ameliorates abnormal behaviors resulting from miR-204-5p deficiency within the vmPFC. Collectively, these results provide robust evidence that the miR-204-5p/JAK2/STAT3 pathway may critically involve in the pathogenesis of depression, which may serve as potentially critical therapeutic target in the treatment of MDD.}, archive = {J_ADVS}, author = {Xiao Chen and Yeting Gan and Kaiqi Zhang and Yuhan Wu and Ye Li and Tian Lan and Xianghua Zhuang and Shihong Chen and Shuyan Yu}, doi = {10.1002/advs.202403080}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2403080}, shortjournal = {Adv. Sci.}, title = {MicroRNA-204-5p deficiency within the vmPFC region contributes to neuroinflammation and behavioral disorders via the JAK2/STAT3 signaling pathway in rats}, volume = {12}, year = {2025}, }
• (2025). Circadian rhythm disruption exacerbates autoimmune uveitis: The essential role of PER1 in treg cell metabolic support for stability and function. ADVS, 12(10), 2400004. (www)

  @article{ , abstract = {Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained unclear. Using a light-induced circadian rhythm disruption model, we showed that disrupted circadian rhythms exacerbate autoimmune uveitis by impairing the stability and function of Treg cells. Mechanistically, we identified the core clock gene Per1 , which is significantly reduced under circadian disruption, is essential for Treg cell metabolism and immunoregulatory function. This study underscores the pivotal role of circadian rhythm-related Treg cells in autoimmune disease progression.}, archive = {J_ADVS}, author = {Wenjie Zhu and Guanyu Chen and Zhiqiang Xiao and Minzhen Wang and Zhuang Li and Yuxun Shi and Xiaohui Luo and Zuoyi Li and Haixiang Huang and Xiaoqing Chen and Lingyi Liang and Dan Liang}, doi = {10.1002/advs.202400004}, journal = {Advanced Science}, month = {3}, number = {10}, pages = {2400004}, shortjournal = {Adv. Sci.}, title = {Circadian rhythm disruption exacerbates autoimmune uveitis: The essential role of PER1 in treg cell metabolic support for stability and function}, volume = {12}, year = {2025}, }
• (2025). Photothermal coating on zinc alloy for controlled biodegradation and improved osseointegration (Adv. sci. 9/2025). ADVS, 12(9), 2570059. (www)

  @article{ , archive = {J_ADVS}, author = {Yuchien Hsu and Yunjiao He and Xiao Zhao and Feilong Wang and Fan Yang and Yufeng Zheng and Yongsheng Zhou and Dandan Xia and Yunsong Liu}, doi = {10.1002/advs.202570059}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2570059}, shortjournal = {Adv. Sci.}, title = {Photothermal coating on zinc alloy for controlled biodegradation and improved osseointegration (Adv. sci. 9/2025)}, volume = {12}, year = {2025}, }
• (2025). 3D femtosecond laser beam deflection for high-precision fabrication and modulation of individual voxelated PCM meta-atoms (Adv. sci. 9/2025). ADVS, 12(9), 2570058. (www)

  @article{ , archive = {J_ADVS}, author = {Weina Han and Donghui Wei and Biye Peng and Jianhui Jiang and Jintao Tong and Zhehao Xu and Xueyan Zou and Jie Hu and Qian Cheng and Lan Jiang}, doi = {10.1002/advs.202570058}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2570058}, shortjournal = {Adv. Sci.}, title = {3D femtosecond laser beam deflection for high-precision fabrication and modulation of individual voxelated PCM meta-atoms (Adv. sci. 9/2025)}, volume = {12}, year = {2025}, }
• (2025). Photothermal effect and biomineralization of black phosphorus nanosheet-composited hydrogel boosts synergistic treatment of dentin hypersensitivity (Adv. sci. 9/2025). ADVS, 12(9), 2570057. (www)

  @article{ , archive = {J_ADVS}, author = {Qihui Wang and Guoliang Wang and Xinru Li and Di Li and Congxiao Zhang and Jianxun Ding}, doi = {10.1002/advs.202570057}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2570057}, shortjournal = {Adv. Sci.}, title = {Photothermal effect and biomineralization of black phosphorus nanosheet-composited hydrogel boosts synergistic treatment of dentin hypersensitivity (Adv. sci. 9/2025)}, volume = {12}, year = {2025}, }
• (2025). Redox-active Co(II) and Zn(II) pincer complexes as high-capacity anode materials for lithium-ion batteries (Adv. sci. 9/2025). ADVS, 12(9), 2570055. (www)

  @article{ , archive = {J_ADVS}, author = {Honggyu Seong and Joon Ha Moon and Youngho Jin and Geongil Kim and Taejung Jung and Hyerin Yoo and Woonghee Lee and Kyounghoon Lee and Se Youn Cho and Jaewon Choi}, doi = {10.1002/advs.202570055}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2570055}, shortjournal = {Adv. Sci.}, title = {Redox-active Co(II) and Zn(II) pincer complexes as high-capacity anode materials for lithium-ion batteries (Adv. sci. 9/2025)}, volume = {12}, year = {2025}, }
• (2025). ShK-modified UCMSCs inhibit m1-like macrophage polarization and alleviate osteoarthritis progression via PI3K/Akt axis (Adv. sci. 9/2025). ADVS, 12(9), 2570054. (www)

  @article{ , archive = {J_ADVS}, author = {Wenshu Wu and Xueying An and Wang Gong and Lin Yang and Na Liu and Bin Liu and Baosheng Guo and Qing Jiang and Lan Li}, doi = {10.1002/advs.202570054}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2570054}, shortjournal = {Adv. Sci.}, title = {ShK-modified UCMSCs inhibit m1-like macrophage polarization and alleviate osteoarthritis progression via PI3K/Akt axis (Adv. sci. 9/2025)}, volume = {12}, year = {2025}, }
• (2025). Haplotype-resolved genotyping and association analysis of 1,020 β-thalassemia patients by targeted long-read sequencing (Adv. sci. 9/2025). ADVS, 12(9), 2570053. (www)

  @article{ , archive = {J_ADVS}, author = {Yuhua Ye and Chao Niu and Aiping Mao and Lang Qin and Jiahan Zhan and Weijie Chen and Zhentian Liu and Tiantian Xie and Qianqian Zhang and Jiaqi Li and Li Huang and Wanli Meng and Yumeng Liu and Liuhua Liao and Junqin Cai and Riyang Liu and Xinhua Zhang and Lihong Zeng and Yaoyun Li and Bin Lin and Kui Li and Xiaoyun Hua and Binbin Huang and Honggui Qin and Yueyan Huang and Zhijing Huang and Jinquan Lao and Xiang Qu and Juanjuan Chen and Xiaoqin Feng and Qiujun Liu and Wanying Lin and Xiaoman Zhou and Yidan Liang and Xingjiang Long and Jiaofeng Qin and Lixiang Yan and Weijian Zhu and Lian Yu and Chengwu Fan and Deguo Tang and Tianyu Zhong and Jufang Tan and Zhilin Ren and Xiangmin Xu}, doi = {10.1002/advs.202570053}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2570053}, shortjournal = {Adv. Sci.}, title = {Haplotype-resolved genotyping and association analysis of 1,020 β-thalassemia patients by targeted long-read sequencing (Adv. sci. 9/2025)}, volume = {12}, year = {2025}, }
• (2025). Cost-effective DNA storage system with DNA movable type (Adv. sci. 9/2025). ADVS, 12(9), 2570052. (www)

  @article{ , archive = {J_ADVS}, author = {Chenyang Wang and Di Wei and Zheng Wei and Dongxin Yang and Jing Xing and Yunze Wang and Xiaotong Wang and Pei Wang and Guannan Ma and Xinru Zhang and Haolan Li and Chuan Tang and Pengfei Hou and Jie Wang and Renjun Gao and Guiqiu Xie and Cuidan Li and Yingjiao Ju and Peihan Wang and Liya Yue and Yongliang Zhao and Yongjie Sheng and Jingfa Xiao and Haitao Niu and Sihong Xu and Huaiyi Yang and Di Liu and Bo Duan and Dongbo Bu and Guangming Tan and Fei Chen}, doi = {10.1002/advs.202570052}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2570052}, shortjournal = {Adv. Sci.}, title = {Cost-effective DNA storage system with DNA movable type (Adv. sci. 9/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “Hierarchically assembled nanofiber scaffolds with dual growth factor gradients promote skin wound healing through rapid cell recruitment”. ADVS, 12(9), 2501010. (www)

  @article{ , archive = {J_ADVS}, author = {Ruyi Fan and Chuwei Zhang and Fei Li and Bo Li and Alec McCarthy and Yi Zhang and Shixuan Chen and Lin Zhang}, doi = {10.1002/advs.202501010}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2501010}, shortjournal = {Adv. Sci.}, title = {Correction to “Hierarchically assembled nanofiber scaffolds with dual growth factor gradients promote skin wound healing through rapid cell recruitment”}, volume = {12}, year = {2025}, }
• (2025). Correction to “RNF126-mediated MRE11 ubiquitination activates the DNA damage response and confers resistance of triple-negative breast cancer to radiotherapy”. ADVS, 12(9), 2417701. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202417701}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2417701}, shortjournal = {Adv. Sci.}, title = {Correction to “RNF126-mediated MRE11 ubiquitination activates the DNA damage response and confers resistance of triple-negative breast cancer to radiotherapy”}, volume = {12}, year = {2025}, }
• (2025). Breaking the trade-off between electrical conductivity and mechanical strength in bulk graphite using Metal–Organic framework-derived precursors. ADVS, 12(9), 2416210. (www)

  @article{ , abstract = {High-performance bulk graphite (HPBG) that simultaneously integrates superior electrical conductivity and excellent strength is in high demand, yet it remains critical and challenging. Herein a novel approach is introduced utilizing MOF-derived nanoporous metal/carbon composites as precursors to circumvent this traditional trade-off. The resulting bulk graphite, composed of densely packed multilayered graphene sheets functionalized with diverse cobalt forms (nanoparticles, single atoms, and clusters), exhibits unprecedented electrical conductivity in all directions (in-plane: 7311 S cm⁻¹, out-of-plane: 5541 S cm⁻¹) and excellent mechanical strength (flexural: 101.17±5.73 MPa, compressive: 151.56±2.53 MPa). Co nanoparticles act as autocatalysts and binders, promoting strong interlayer adhesion among highly graphitized graphene layers via spark plasma sintering. The strong nano-interfaces between graphite and Co-create critical bridges between graphene nanosheets, facilitating highly efficient electron migration and enhanced strength and stiffness of the assembled bulk nanocomposites. Leveraging these exceptional properties, practical demonstrations highlight the immense potential of the robust material for applications demanding superior electromagnetic interference shielding and efficient heating. An innovative approach, which effectively decouples electrical conductivity from mechanical properties, paves the way for the creation of HPBGs tailored for diverse application sectors.}, archive = {J_ADVS}, author = {Yuqing Zhang and Junzhuo Wang and Yinghan Zhang and Qi Zheng and Lianjun Wang and Wan Jiang}, doi = {10.1002/advs.202416210}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2416210}, shortjournal = {Adv. Sci.}, title = {Breaking the trade-off between electrical conductivity and mechanical strength in bulk graphite using Metal–Organic framework-derived precursors}, volume = {12}, year = {2025}, }
• (2025). Synergetic contributions of high quenching concentration and tuned square antiprism geometry boosting far-red emission of eu3+ with near-unit efficiency. ADVS, 12(9), 2415989. (www)

  @article{ , abstract = {Far-red phosphors have emerged as a desirable research hotspot owing to their critical role in promoting plant growth. Especially, Eu 3+ ions typically present the 5 D 0 → 7 F J (J = 0, 1, 2, 3, 4) transitions, which overlap with the far-red light required for plant photosynthesis. However, achieving high-efficiency far-red emission of Eu 3+ remains challenging due to weak 5 D 0 → 7 F 4 transition and concentration quenching. The study constructs two anomalously efficient far-red garnet phosphors A 3 Sc 2 C 3 O 12 (A = Y 3+ , Gd 3+ . C = Al 3+ , Ga 3+ ):Eu 3+ . A high-resolution STEM measurement equipped with an aberration corrector provides the direct proofs for both the [EuO 8 ] configuration-dependent strong 5 D 0 → 7 F 4 and the origin of high quenching concentration. Excitedly, a two-component substitution (replacing Y 3+ -Al 3+ with Gd 3+ -Ga 3+ ) triggers a near-unity internal quantum efficiency (IQE = 99.01%) and high external quantum efficiency (EQE = 38.73%) in Gd 3 Sc 2 Ga 3 O 12 :60%Eu 3+ , resulting from the effective modulation of 5 D 0 → 7 F 4 / 7 F 2 transitions. A far-red LEDs device based on Gd 3 Sc 2 Ga 3 O 12 :60%Eu 3+ exhibits an output power of 113 mW at 300 mA. Subsequently, practical applications for promoting plant growth underscore the significance of these findings. This work opens a new path for the development of highly efficient far-red phosphors via the synergistic effect of Eu 3+ square antiprism configuration and high quenching concentration.}, archive = {J_ADVS}, author = {Hong Li and Asif Ali Haider and Zhi Xie and Conglin Liu and Hongzhi Zhang and Hongming Jiang and Junpeng Li and Jing Zhu}, doi = {10.1002/advs.202415989}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415989}, shortjournal = {Adv. Sci.}, title = {Synergetic contributions of high quenching concentration and tuned square antiprism geometry boosting far-red emission of eu3+ with near-unit efficiency}, volume = {12}, year = {2025}, }
• (2025). Machine learning-driven prediction, preparation, and evaluation of functional nanomedicines via Drug–Drug self-assembly. ADVS, 12(9), 2415902. (www)

  @article{ , abstract = {Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-assembling nanomedicines, employing physiochemical parameters to predict formation via machine learning. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are identified as effective carriers for antineoplastic drugs, with high drug loading. Nanomedicines, PEG-coated indomethacin/paclitaxel nanomedicine (PiPTX), and laminarin-modified indomethacin/paclitaxel nanomedicine (LiDOX), are developed with extended circulation and active targeting functions. Indomethacin/paclitaxel nanomedicine iDOX exhibits pH-responsive drug release in the tumor microenvironment. These nanomedicines enhance anti-tumor effects and reduce side effects, offering a rapid approach to clinical nanomedicine development.}, archive = {J_ADVS}, author = {Chengyuan Zhang and Yuchuan Yuan and Qiong Xia and Junjie Wang and Kangkang Xu and Zhiwei Gong and Jie Lou and Gen Li and Lu Wang and Li Zhou and Zhirui Liu and Kui Luo and Xing Zhou}, doi = {10.1002/advs.202415902}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415902}, shortjournal = {Adv. Sci.}, title = {Machine learning-driven prediction, preparation, and evaluation of functional nanomedicines via Drug–Drug self-assembly}, volume = {12}, year = {2025}, }
• (2025). Boosting the hydrogen evolution activity of a low-coordinated Co─N─C catalyst via vacancy defect-mediated alteration of the intermediate adsorption configuration. ADVS, 12(9), 2415665. (www)

  @article{ , abstract = {The cobalt-nitrogen-carbon (Co─N─C) single-atom catalysts (SACs) are promising alternatives to precious metals for catalyzing the hydrogen evolution reaction (HER) and their activity is highly dependent on the coordination environments of the metal centers. Herein, a NaHCO 3 etching strategy is developed to introduce abundant in-plane pores within the carbon substrates that further enable the construction of low-coordinated and asymmetric Co─N 3 sites with nearby vacancy defects in a Co─N─C catalyst. This catalyst exhibits a high HER activity with an overpotential ( η ) of merely 78 mV to deliver a current density of 10 mA cm −2 , a Tafel slope of 45.2 mV dec −1 , and a turnover frequency of 1.67 s −1 (at η = 100 mV). Experimental investigations and theoretical calculations demonstrate that the vacancy defects neighboring the Co─N 3 sites can modulate the electronic structure of the catalyst and alter the adsorption configuration of the H intermediate from the typical atop mode to the side mode, resulting in weakened H adsorption strength and thus improved HER activity. This work provides an efficient strategy to regulate the coordination environment of SACs for improved catalytic performance and sheds light on the atomic-level understanding of the structure-activity relationships.}, archive = {J_ADVS}, author = {Qianwei Song and Zhichao Gong and Jianbin Liu and Kang Huang and Gonglan Ye and Shuwen Niu and Huilong Fei}, doi = {10.1002/advs.202415665}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415665}, shortjournal = {Adv. Sci.}, title = {Boosting the hydrogen evolution activity of a low-coordinated Co─N─C catalyst via vacancy defect-mediated alteration of the intermediate adsorption configuration}, volume = {12}, year = {2025}, }
• (2025). Quantifying magnetic anisotropy of series of five-coordinate CoII ions: Experimental and theoretical insights. ADVS, 12(9), 2415624. (www)

  @article{ , abstract = {Stabilizing large easy-axis type magnetic anisotropy in molecular complexes is a challenging task, yet it is crucial for the development of information storage devices and applications in molecular spintronics. Achieving this requires a deep understanding of electronic structure and the relationships between structure and properties to develop magneto-structural correlations that are currently unexplored in the literature. Herein, a series of five-coordinate distorted square pyramidal Co II complexes [Co(L)(X 2 )].CHCl 3 (where X = Cl ( 1 ), Br ( 2 ), or I ( 3 )) is reported, all exhibiting easy-axis magnetic anicotropy. The size of the zero field splitting axial parameter ( D ) is quantitatively determined ( 1 = −72; 2 = −67 and 3 = −25 cm −1 ) using a cantilever torque magnetometry which is further firmly supported by magnetic susceptibility, and EPR measurements. The study of the magnetization relaxation dynamics reveals field-induced slow relaxation of magnetization due to the predominant Raman relaxation process. Theoretical calculations on 1 – 3 and optimized model complexes of 1 reveal insights into the electronic structure and highlight the impact of steric and electronic effects on modulating the D values. Overall, the studies reported pave the way for designing a new generation of Co II complexes with enhanced  axiality and a lower rhombicity.}, archive = {J_ADVS}, author = {Vijaya Thangaraj and Daniele Sartini and Dipanti Borah and Deepanshu Chauhan and Vasudha Sharma and Lorenzo Sorace and Gopalan Rajaraman and Mauro Perfetti and Maheswaran Shanmugam}, doi = {10.1002/advs.202415624}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415624}, shortjournal = {Adv. Sci.}, title = {Quantifying magnetic anisotropy of series of five-coordinate CoII ions: Experimental and theoretical insights}, volume = {12}, year = {2025}, }
• (2025). On-chip metamaterial-enhanced mid-infrared photodetectors with built-in encryption features. ADVS, 12(9), 2415518. (www)

  @article{ , abstract = {The integration of mid-infrared (MIR) photodetectors with built-in encryption capabilities holds immense promise for advancing secure communications in decentralized networks and compact sensing systems. However, achieving high sensitivity, self-powered operation, and reliable performance at room temperature within a miniaturized form factor remains a formidable challenge, largely due to constraints in MIR light absorption and the intricacies of embedding encryption at the device level. Here, a novel on-chip metamaterial-enhanced, 2D tantalum nickel selenide (Ta₂NiSe₅)-based photodetector, meticulously designed with a custom-engineered plasmonic resonance microstructure to achieve self-powered photodetection in the nanoampere range is unveiled. Gold cross-shaped resonators are demonstrated that generate plasmon-induced ultrahot electrons, significantly enhancing the absorption of MIR photons with energies far below the bandgap and boosting electron thermalization in Ta₂NiSe₅, yielding a 0.1 V bias responsivity of 47 mA/W—an order of magnitude higher than previously reported values. Furthermore, the implementation of six reconfigurable optoelectronic logic computing (“AND”, “OR”, “NAND”, “NOR”, “XOR”, and “XNOR”) are illustrated via tailored optical and electrical input-output configurations, thereby establishing a platform for real-time infrared-encrypted communication. This work pioneers a new direction in secure MIR communications, advancing the development of high-performance, encryption-capable photonic systems.}, archive = {J_ADVS}, author = {Shicong Hou and Li Han and Shi Zhang and Libo Zhang and Kaixuan Zhang and Kening Xiao and Yao Yang and Yunduo Zhang and Yuanfeng Wen and Wenqi Mo and Yiran Tan and Yifan Yao and Jiale He and Weiwei Tang and Xuguang Guo and Yiming Zhu and Xiaoshuang Chen}, doi = {10.1002/advs.202415518}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415518}, shortjournal = {Adv. Sci.}, title = {On-chip metamaterial-enhanced mid-infrared photodetectors with built-in encryption features}, volume = {12}, year = {2025}, }
• (2025). Superior multimodal luminescence in a stable single-host nanomaterial with large-scale synthesis for high-level anti-counterfeiting and encryption. ADVS, 12(9), 2415473. (www)

  @article{ , abstract = {Multimode luminescent materials exhibit tunable photon emissions under different excitation or stimuli channels, endowing them high encoding capacity and confidentiality for anti-counterfeiting and encryption. Achieving multimode luminescence into a stable single material presents a promising but remains a challenge. Here, the downshifting/upconversion emissions, color-tuning persistent luminescence (PersL), temperature-dependent multi-color emissions, and hydrochromism are integrated into Er 3+ ions doped Cs 2 NaYbCl 6 nanocrystals (NCs) by leveraging shallow defect levels and directed energy migration. The resulting NCs display strong static and dynamic colorful luminescence in response to ultraviolet, 980-nm laser, and X-ray. Additionally, the NCs exhibit distinct luminescent colors as the temperature increases from 330 to 430 K. Surprisingly, it also demonstrates the ability of the reversible emission modal and color in response to water. Theoretical calculations and experimental characterizations reveal that self-trapped exciton state (STEs), chlorine vacancy defects, and ladderlike 4f energy levels of Er 3+ ions contribute to multimodal luminescence. More importantly, it has extremely remarkable environmental stability, which can be stored in the air for more than 18 months, showing promising commercial prospects. This work not only gives new insights into lanthanide-based metal halide NCs but also provides a new route for developing multimodal luminescent nanomaterials for anti-counterfeiting and encryption.}, archive = {J_ADVS}, author = {Bingyin Kong and Gencai Pan and Mengke Wang and Hongye Tang and Zhipeng Lv and Shiyu Sun and Yuxin Luo and Wenwu You and Wen Xu and Yanli Mao}, doi = {10.1002/advs.202415473}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415473}, shortjournal = {Adv. Sci.}, title = {Superior multimodal luminescence in a stable single-host nanomaterial with large-scale synthesis for high-level anti-counterfeiting and encryption}, volume = {12}, year = {2025}, }
• (2025). Stability of proton superoxide and its superionic transition under high pressure. ADVS, 12(9), 2415387. (www)

  @article{ , abstract = {Under extreme conditions, condensed matters are subject to undergo a phase transition and there have been many attempts to find another form of hydroxide stabilized over H 2 O. Here, using Density Functional Theory (DFT)-based crystal structure prediction including zero-point energy, it is that proton superoxide (HO 2 ), the lightest superoxide, can be stabilized energetically at high pressure and temperature conditions. HO 2 is metallic at high pressure, which originates from the 𝜋 * orbitals overlap between adjacent superoxide anions (O 2 − ). By lowering pressure, it undergoes a metal-to-insulator transition similar to LiO 2 . Ab initio molecular dynamics (AIMD) calculations reveal that HO 2 becomes superionic with high electrical conductivity. The possibility of creating hydrogen-mixed superoxide at lower pressure using a (Li x ,H 1-x )O 2 hypothetical structure is also proposed. This discovery bridges gaps in superoxide and superionicity, guiding the design of various H-O compounds under high pressure.}, archive = {J_ADVS}, author = {Zifan Wang and Wenge Yang and Duck Young Kim}, doi = {10.1002/advs.202415387}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415387}, shortjournal = {Adv. Sci.}, title = {Stability of proton superoxide and its superionic transition under high pressure}, volume = {12}, year = {2025}, }
• (2025). From monocyclization to pentacyclization: A versatile plant cyclase produces diverse sesterterpenes with anti-liver fibrosis potential. ADVS, 12(9), 2415370. (www)

  @article{ , abstract = {A prolific multi-product sesterterpene synthase CbTPS1 is characterized from the medicinal Brassicaceae plant Capsella bursa-pastoris . Twenty different sesterterpenes including 16 undescribed compounds, possessing 10 different mono-/di-/tri-/tetra-/penta-carbocyclic skeletons, including the unique 15-membered macrocyclic and 24(15→14)- abeo -capbuane scaffolds, are isolated and structurally elucidated from engineered Escherichia coli strains expressing CbTPS1. Site-directed mutagenesis assisted by molecular dynamics simulations resulted in the variant L354 M with up to 13.2-fold increased sesterterpene production. These structurally diverse products suggest a comprehensive cyclization mechanism for plant sesterterpenes and provide compelling evidence for the initial cyclization of geranylfarnesyl diphosphate via a crucial 15-membered monocyclic carbocation. The activities of these sesterterpenes against liver fibrosis is inferred from the inhibition of the transforming growth factor-β/Smad signaling pathway and collagen synthesis. These findings greatly expand the chemical space and biological functions of sesterterpenes and provide new insights into the catalytic mechanism of terpene synthases.}, archive = {J_ADVS}, author = {Kai Guo and Xue Tang and Yan-Chun Liu and Hui-Zhen Cheng and Huan Liu and Yu-Zhou Fan and Xiao-Yu Qi and Rui Xu and Juan-Juan Kang and De-Sen Li and Guo-Dong Wang and Jonathan Gershenzon and Yan Liu and Sheng-Hong Li}, doi = {10.1002/advs.202415370}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415370}, shortjournal = {Adv. Sci.}, title = {From monocyclization to pentacyclization: A versatile plant cyclase produces diverse sesterterpenes with anti-liver fibrosis potential}, volume = {12}, year = {2025}, }
• (2025). Cell-type specific miRNA regulatory network responses to ABA stress revealed by time series transcriptional atlases in arabidopsis. ADVS, 12(9), 2415083. (www)

  @article{ , abstract = {In plants, microRNAs (miRNAs) participate in complex gene regulatory networks together with the transcription factors (TFs) in response to biotic and abiotic stresses. To date, analyses of miRNAs-induced transcriptome remodeling are at the whole plant or tissue levels. Here, Arabidopsis ’s ABA-induced single-cell RNA-seq (scRNA-seq) is performed at different stages of time points–early, middle, and late. Single-cell level primary miRNAs (pri-miRNAs) atlas supported the rapid, dynamic, and cell-type specific miRNA responses under ABA treatment. MiRNAs respond rapidly and prior to target gene expression dynamics, and these rapid response miRNAs are highly cell-type specific, especially in mesophyll and vascular cells. MiRNA-TF-mRNA regulation modules are identified by identifying miRNA-contained feed-forward loops (M-FFLs) in the regulatory network, and regulatory networks with M-FFLs have higher co-expression and clustering coefficient (CC) values than those without M-FFLs, suggesting the hub role of miRNAs in regulatory networks. The cell-type-specific M-FFLs are regulated by these hub miRNAs rather than TFs through sc-RNA-seq network analysis. MiR858a-FBH3-MYB module inhibited the expression of MYB63 and MYB20, which related to the formation of plant secondary wall and the production of lignin, through M-FFL specifically in vascular. These results can provide prominent insights into miRNAs' dynamic and cell-type-specific roles in plant development and stress responses.}, archive = {J_ADVS}, author = {Zhaoxu Gao and Yanning Su and Guanzhong Jiao and Zhiying Lou and Le Chang and Renbo Yu and Chao Xu and Xue Han and Zejia Wang and Jian Li and Xing Wang Deng and Hang He}, doi = {10.1002/advs.202415083}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2415083}, shortjournal = {Adv. Sci.}, title = {Cell-type specific miRNA regulatory network responses to ABA stress revealed by time series transcriptional atlases in arabidopsis}, volume = {12}, year = {2025}, }
• (2025). Visible-light-driven fluorescence turn-on photoswitches with near quantitative photocyclization yield. ADVS, 12(9), 2414881. (www)

  @article{ , abstract = {Photoswitchable fluorescent materials have gained significant attention for their potential in advanced information encryption and anti-counterfeiting applications. However, the common use of UV light to trigger the isomerization processes leads to photobleaching and poor fatigue resistance. Visible-light-driven fluorescent photoswitches are highly desirable, but achieving high cyclization yield remains challenging. Herein, it is reported that all visible-light-driven turn-on fluorescence in dimethoxyphenyl functionalized diarylethene isomers. The open-ring form of o - DMPB and p - DMPB exhibits near quantitative conversion yields (up to 94%) under 405 nm visible light, attributed to the strong electron-donating character. In contrast, the meta isomer m - DMPB shows limited response to visible light, with a ring-closing yield of 22%. Furthermore, all photoswitches display good thermal stability, photostability, and fatigue resistance. Notably, o - DMPB demonstrates promising applications in anti-counterfeiting, information encryption, and photorewritable patterns. This work provides a valuable strategy for the development of high-performance fluorescent photoswitches.}, archive = {J_ADVS}, author = {Jiawei Zhai and Qi Ai and Huaqing Li and Zugang Liu and Xiaoguang Hu}, doi = {10.1002/advs.202414881}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414881}, shortjournal = {Adv. Sci.}, title = {Visible-light-driven fluorescence turn-on photoswitches with near quantitative photocyclization yield}, volume = {12}, year = {2025}, }
• (2025). Deciphering the energy transfer mechanism across metal halide perovskite-phthalocyanine interfaces. ADVS, 12(9), 2414831. (www)

  @article{ , abstract = {Energy transfer processes in nanohybrids are at the focal point of conceptualizing, designing, and realizing novel energy-harvesting systems featuring nanocrystals that absorb photons and transfer their energy unidirectionally to surface-immobilized functional dyes. Importantly, the functionality of these dyes defines the ultimate application. Herein, CsPbBr 3 perovskite nanocrystals (NCs) are interfaced with zinc phthalocyanine (ZnPc) dyes featuring carboxylic acid. The functionality is the photosensitization of singlet oxygen. The CsPbBr 3 @ZnPc nanohybrid is to the best of our knowledge the first example, in which an unusual Dexter-type singlet energy transfer between metal halide perovskite nanocrystals and phthalocyanine dyes enables singlet oxygen generation as a proof-of-concept application. A detailed temporal picture of the singlet energy transfer mechanism is made possible by combining key time-resolved spectroscopic techniques, that are, femtosecond, nanosecond, and microsecond transient absorption spectroscopy as well as time-correlated single photon counting, and target analyses. In fact, three excitonic components in the NCs govern a concerted Dexter-type energy transfer. The work illustrates the potential of CsPbBr 3 @ZnPc as a singlet photosensitizer of ZnPc to produce singlet oxygen ( 1 O 2 ) almost quantitatively while photoexciting CsPbBr 3 .}, archive = {J_ADVS}, author = {Alejandro Cortés-Villena and Alejandro Cadranel and Kobra Azizi and Tomás Torres and Dirk M. Guldi and Julia Pérez-Prieto and Raquel E. Galian}, doi = {10.1002/advs.202414831}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414831}, shortjournal = {Adv. Sci.}, title = {Deciphering the energy transfer mechanism across metal halide perovskite-phthalocyanine interfaces}, volume = {12}, year = {2025}, }
• (2025). Antiferroelectric order in nematic liquids: Flexoelectricity versus electrostatics. ADVS, 12(9), 2414818. (www)

  @article{ , abstract = {The recent discovery of ferroelectric nematic liquid crystalline phases marks a major breakthrough in soft matter research. An intermediate phase, often observed between the nonpolar and the ferroelectric nematic phase, shows a distinct antiferroelectric response to electric fields. However, its structure and formation mechanisms remain debated, with flexoelectric and electrostatics effects proposed as competing mechanisms. By controlling the magnitude of electrostatic forces through ion addition in two representative ferroelectric nematic materials, it is shown that the primary mechanism for the emergence of antiferroelectric order is the flexoelectric coupling between electric polarization and splay deformation of the nematic director. The addition of ions significantly expands the temperature range over which the antiferroelectric phase is observed, with this range increasing with increasing ion concentration. Polarizing optical microscopy studies and second harmonic generation (SHG) microscopy reveal the splayed structure modulated in 2D, while SHG interferometry confirms its antiferroelectric character. The model previously used to describe pretransitional behavior is extended by incorporating the electrostatic contribution of ions. The model shows qualitative agreement with the experiments, accurately reproducing the phase diagram and temperature-dependent evolution of the modulation period of the observed structure.}, archive = {J_ADVS}, author = {Peter Medle Rupnik and Ema Hanžel and Matija Lovšin and Natan Osterman and Calum Jordan Gibb and Richard J. Mandle and Nerea Sebastián and Alenka Mertelj}, doi = {10.1002/advs.202414818}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414818}, shortjournal = {Adv. Sci.}, title = {Antiferroelectric order in nematic liquids: Flexoelectricity versus electrostatics}, volume = {12}, year = {2025}, }
• (2025). A susceptible cell-selective delivery (SCSD) of mRNA-encoded cas13d against influenza infection. ADVS, 12(9), 2414651. (www)

  @article{ , abstract = {To bolster the capacity for managing potential infectious diseases in the future, it is critical to develop specific antiviral drugs that can be rapidly designed and delivered precisely. Herein, a CRISPR/Cas13d system for broad-spectrum targeting of influenza A virus (IAV) from human, avian, and swine sources is designed, incorporating Cas13d mRNA and a tandem CRISPR RNA (crRNA) specific for the highly conserved regions of viral polymerase acidic (PA), nucleoprotein (NP), and matrix (M) gene segments, respectively. Given that the virus targets cells with specific receptors but is not limited to a single organ, a Susceptible Cell Selective Delivery (SCSD) system is developed by modifying a lipid nanoparticle with a peptide mimicking the function of the hemagglutinin of influenza virus to target sialic acid receptors. The SCSD system can precisely deliver an all-RNA-based CRISPR/Cas13d system into potentially infected cells. This drug is shown to reduce the viral load in the lungs by 2.37 log 10 TCID 50 mL −1 and protect 100% of mice from lethal influenza infection. The SCSD-based CRISPR/Cas13d system shows promise for the flexible and efficient therapy of infections caused by rapidly evolving and novel viruses.}, archive = {J_ADVS}, author = {Zhuanli Wu and Chengcheng Zhao and Hui Ai and Zhen Wang and Mingyue Chen and Yanli Lyu and Qi Tong and Litao Liu and Honglei Sun and Juan Pu and Ran Zhang and Xiaoxiang Hu and Jinhua Liu and Xiaowei Ma and Yipeng Sun}, doi = {10.1002/advs.202414651}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414651}, shortjournal = {Adv. Sci.}, title = {A susceptible cell-selective delivery (SCSD) of mRNA-encoded cas13d against influenza infection}, volume = {12}, year = {2025}, }
• (2025). From radioactive effluent to drinking water: Efficient removal of trace 99TcO4−/ReO4− by cationic porous aromatic framework. ADVS, 12(9), 2414604. (www)

  @article{ , abstract = {Efficient removal of 99 TcO 4 − from radioactive effluents while recovering drinking water remains a challenge. Herein, an excellent ReO 4 − (a nonradioactive surrogate of 99 TcO 4 − ) scavenger is presented through covalently bonding imidazolium poly(ionic liquids) polymers with an ionic porous aromatic framework (iPAF), namely iPAF-P67, following an adsorption-site density-addition strategy. It shows rapid sorption kinetics, high uptake capacity, and exceptional selectivity toward ReO 4 − . Notably, the residual concentration of TcO 4 − /ReO 4 − in the radioactive wastewater after iPAF-P67 treatment is as low as 0.046 ppb, fully meeting the drinking water standards of World Health Organization (WHO, 0.159 ppb) and United States Environmental Protection Agency (U.S. EPA, 0.053 ppb). Density functional theory (DFT) calculations show that the imidazolium groups in iPAF-P67 provide stronger electrostatic interactions and higher binding energies between iPAF-P67 and TcO 4 − anions, leading to its superior adsorption performance. Furthermore, the scale-up synthesized iPAF-P67 materials are shaped with polyethersulfone (PES) to fabricate PAF-P67/PES beads and nanofibers via phase inversion method and electrospinning technique, respectively. Both composites demonstrate outstanding ultra-purification abilities toward ReO 4 − to meet the WHO criteria even after multiple dynamic adsorption/desorption cycles. This work develops a design strategy for adsorbents applicable in the sequestration of low-concentration radioactive pollutants.}, archive = {J_ADVS}, author = {Long-Sheng Pang and Xiangjun Liao and Chao-Yue Zhao and Cheng-Peng Li and Zhong Liu and Shengqian Ma}, doi = {10.1002/advs.202414604}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414604}, shortjournal = {Adv. Sci.}, title = {From radioactive effluent to drinking water: Efficient removal of trace 99TcO4−/ReO4− by cationic porous aromatic framework}, volume = {12}, year = {2025}, }
• (2025). Mechanoluminescence from Organic–Inorganic metal halide perovskite derivative. ADVS, 12(9), 2414588. (www)

  @article{ , abstract = {Metal halide perovskites and their derivatives are gaining significant attention as photoluminescent materials due to their exceptional light-emitting properties. However, most research has concentrated on electroluminescence and photoluminescence, there remains a substantial gap in the exploration of mechanoluminescence (ML) properties in perovskites, making this field largely uncharted. ML is an ancient and intriguing luminescent phenomenon that occurs when a material is subjected to mechanical forces. Here, the discovery of the first organic–inorganic hybrid terbium (Tb 3+ )-based metal halide, a type of perovskite derivative, which exhibits notable ML properties is reported. Through material orthogonal design, the critical roles played by molecular geometry and metal-site ions in achieving remarkable ML in organic–inorganic hybrid metal halides are identified.}, archive = {J_ADVS}, author = {Hongyuan Zhao and Xinyu Yang and Yunfei Bai and Qichao Meng and Ziying Wen and Haibo Sun and Qilin Wei and Dan Huang and William W. Yu and Feng Liu}, doi = {10.1002/advs.202414588}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414588}, shortjournal = {Adv. Sci.}, title = {Mechanoluminescence from Organic–Inorganic metal halide perovskite derivative}, volume = {12}, year = {2025}, }
• (2025). Ferroelectric nematic liquid crystals showing high birefringence. ADVS, 12(9), 2414317. (www)

  @article{ , abstract = {High birefringence nematic liquid crystals are particularly demanded for adaptive optics applications in the infrared spectrum because it enable a thinner cell gap for achieving fast response time and improved diffraction efficiency. The emerging ferroelectric nematic liquid crystals have attracted widespread interest in soft matter due to their unique combination of ferroelectricity and fluidity. However, the birefringence, which is one of the most important optical parameters in electro-optic devices, is not large enough (<0.25) in most ferroelectric nematic materials. Here, a polar liquid crystal molecule library containing more than 60 molecules with a highly rigid and fluorinated nature is developed. The introduction of triple bonds constructs a long π-electron conjugated mesogen skeleton, significantly improving the birefringence of polar liquid crystal phases. The birefringence and dispersion properties are systematically studied, demonstrating a strong dependence on chemical structures and the type of polar phases. Furthermore, through multi-component mixing, polar liquid crystal mixtures with ultra-wide temperature range and excellent stability at or near room temperature are obtained. They possess much higher birefringence than the existing ferroelectric liquid crystal materials. The unique combination of high birefringence and fluidic ferroelectricity is expected to promote the application of polar liquid crystals in electro-optic technologies.}, archive = {J_ADVS}, author = {Yaohao Song and Xiang Huang and Xinxin Zhang and Minghui Deng and Satoshi Aya and Mingjun Huang}, doi = {10.1002/advs.202414317}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414317}, shortjournal = {Adv. Sci.}, title = {Ferroelectric nematic liquid crystals showing high birefringence}, volume = {12}, year = {2025}, }
• (2025). Cryoshocked adipocytes mediated dual-modal strategy combining photodynamic therapy and triptolide palmitate for pulmonary metastatic melanoma treatment. ADVS, 12(9), 2414307. (www)

  @article{ , abstract = {Pulmonary metastasis represents one of the most prevalent forms of metastasis in advanced melanoma, with mortality rates reaching 70%. Current treatments including chemotherapy, targeted therapy, and immunotherapy frequently exhibit limited efficacy or present high costs. To address these clinical needs, this study presents a biomimetic drug delivery system (Ce6-pTP-CsA) utilizing cryoshocked adipocytes (CsA) encapsulating the prodrug triptolide palmitate (pTP) and the photosensitizer Ce6, exploiting the characteristic of tumor cells to recruit and lipolyze adipocytes for energy. CsA substantially enhances the drug-loading capacity of adipocytes, with its particle size characteristics enabling targeted delivery of pTP to the lungs. The combination of photodynamic therapy (PDT) and pTP activates the caspase cascade, promoting apoptosis in tumor cells. Notably, the cleavage of disulfide bonds in pTP depletes glutathione (GSH), reducing its scavenging effect on reactive oxygen species (ROS) and enhancing the efficacy of PDT. Results demonstrate that Ce6-pTP-CsA effectively inhibits the proliferation and invasion of pulmonary metastatic melanoma cells in vitro and induces apoptosis, while significantly suppressing lung metastasis of SCID mice models in vivo. In conclusion, this novel biomimetic drug delivery system based on adipocytes provides a promising strategy for targeted therapy in pulmonary metastatic melanoma.}, archive = {J_ADVS}, author = {Aixue Li and Fu Qi and Yuanye Zeng and Rongmei Liu and Huanhuan Cai and Mengyuan He and Dan Li and Yongwei Gu and Jiyong Liu}, doi = {10.1002/advs.202414307}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414307}, shortjournal = {Adv. Sci.}, title = {Cryoshocked adipocytes mediated dual-modal strategy combining photodynamic therapy and triptolide palmitate for pulmonary metastatic melanoma treatment}, volume = {12}, year = {2025}, }
• (2025). Ultramicroporous tröger's base framework membranes with ionized sub-nanochannels for efficient Acid/Alkali recovery. ADVS, 12(9), 2414280. (www)

  @article{ , abstract = {Membrane technology holds significant potential for the recovery of acids and alkalis from industrial wastewater systems, with ion exchange membranes (IEMs) playing a crucial role in these applications. However, conventional IEMs are limited to separating only monovalent cations or anions, presenting a significant challenge in achieving concomitant H⁺/OH⁻ permselectivity for simultaneous acid and alkali recovery. To address this issue, the charged microporous polymer framework membranes are developed, featuring rigid Tröger's Base network chains constructed through a facile sol-gel process. The intrinsic ultramicropore confinement and quaternary ammonium-charged functional groups provide ultrahigh size-sieving capability and enhanced Donnan exclusion for H⁺/OH⁻ selectivity; meanwhile, the internal protoplasmic channels of the polymer frameworks serve as highways for rapid ion transfer. The resulting membrane achieves high H⁺/Fe 2 ⁺ and OH⁻/WO₄ 2 ⁻ selectivities of 694.4 and 181.0, respectively, for concurrent acid and alkali separation in diffusion dialysis and electrodialysis processes over extended operational periods (exceeding 1600 and 600 h, respectively), while maintaining remarkable transport rates. These results outperform most literature-reported and nearly all commercially available membranes. This study validates the novel applicability of polymer framework materials with ionized angstrom-scale channels and versatile functionalities in high-performance IEMs for acid/alkali resource recovery.}, archive = {J_ADVS}, author = {Haopan Sun and Ning Gan and Yuqing Lin and Baolong Wu and Yulong Qiu and Jingwen Su and Ziding Zhou and Fengyin Zou and Jianguo Yu and Hideto Matsuyama}, doi = {10.1002/advs.202414280}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414280}, shortjournal = {Adv. Sci.}, title = {Ultramicroporous tröger's base framework membranes with ionized sub-nanochannels for efficient Acid/Alkali recovery}, volume = {12}, year = {2025}, }
• (2025). Band tailoring enabled perovskite devices for X-ray to near-infrared photodetection. ADVS, 12(9), 2414259. (www)

  @article{ , abstract = {Perovskite semiconductors have shown significant promise for photodetection due to their low effective carrier masses and long carrier lifetimes. However, achieving balanced detection across a broad spectrum—from X-rays to infrared—within a single perovskite photodetector presents challenges. These challenges stem from conflicting requirements for different wavelength ranges, such as the narrow bandgap needed for infrared detection and the low dark current necessary for X-ray sensitivity. To address this, this study have designed a type-II FAPbI 3 perovskite-based heterojunction featuring a large energy band offset utilizing narrow bandgap tellurium (Te) semiconductor. This innovative design broadens the detection range into the infrared while simultaneously reducing dark current noise. As-designed device allows for the detection of near infrared band, achieving a detectivity of 6.8 × 10 9 Jones at 1550 nm. The low dark current enables X-ray sensitivity of up to 1885.1 µC Gy⁻¹ cm⁻ 2 . First-principles calculations confirm the type-II band structure alignment of the heterojunction, and a self-driven response behavior is realized. Moreover, this study have developed a scalable 40 × 1 sensor array, demonstrating the potential for wide-spectrum imaging applications. This work is expected to advance the application of perovskite-based wide-spectrum devices.}, archive = {J_ADVS}, author = {Yi-Chu He and Guan-Hua Dun and Jun Deng and Jia-Li Peng and Ken Qin and Jia-He Zhang and Xiang-Shun Geng and Min-Shu Zhang and Ze-Shu Wang and Yan Xie and Zhao-Qiang Bai and Dan Xie and He Tian and Yi Yang and Tian-Ling Ren}, doi = {10.1002/advs.202414259}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414259}, shortjournal = {Adv. Sci.}, title = {Band tailoring enabled perovskite devices for X-ray to near-infrared photodetection}, volume = {12}, year = {2025}, }
• (2025). On-demand controlled release multi-drugs delivery system for spatiotemporally synergizing antitumor immunotherapy. ADVS, 12(9), 2414233. (www)

  @article{ , abstract = {Although cytotoxic T lymphocytes (CTLs) activation combined with programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) axis blockade have emerged as an effective strategy to improve immunotherapeutic potency, it remains challenging to realize the spatiotemporal synergy of these two components. Herein, the study reports an engineered bacterial-based delivery system that can simultaneously promote CTLs infiltration and control PD-L1 binding protein (PD-L1 trap) release on demand at tumor site. The drug release button of this tumor targeting system is the specific temperature, which is accomplished by dual-modified melanin nanoparticles with photothermal conversion capacity on the engineered bacterial. These dual-modified nanoparticles can form in situ reservoir of heat supplier and antitumor immunity activator once arriving at tumor microenvironment (TME). Importantly, the study establishes the personalized administration regimen according to TME changes, and perform local laser irradiation to trigger PD-L1 trap production only in TME when infiltrated CTLs reach the highest level. This work provides a flexible platform for optimizing cancer immunotherapy.}, archive = {J_ADVS}, author = {Chenglin Liang and Hanxiao Yang and Tongtong Li and Xiaojuan Jiang and Xinni Li and Chen Gao and Lin Hou}, doi = {10.1002/advs.202414233}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414233}, shortjournal = {Adv. Sci.}, title = {On-demand controlled release multi-drugs delivery system for spatiotemporally synergizing antitumor immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Radiative warming glass for high-latitude cold regions. ADVS, 12(9), 2414192. (www)

  @article{ , abstract = {Traditional window glazing, with inherently adverse energy-efficient optical properties, leads to colossal energy losses. Energy-saving glass requires a customized optical design for different climate zones. Compared with the widely researched radiative cooling technology which is preferable to be used in low-altitude hot regions; conversely in high-latitude cold regions, high solar transmittance ( T sol ) and low mid-infrared thermal emissivity ( ε MIR ) are the key characteristics of high-performance radiative warming window glass, while the current low-emissivity (low-e) glass is far from ideal. To address this issue, Drude's theory is used to numerically design a near-ideal film with specified electron density ( n e ) and electron mobility ( µ e ). The fabricated hydrogen-doped indium oxide (IHO) could achieve high T sol (0.836) and low ε MIR (0.117). Energy-saving simulations further reveal a substantial decrease in annual heating energy consumption up to 6.6% across high-latitude regions (climate zones 6 to 8), translating to a corresponding reduction in CO 2 emissions (20.0 kg m −2 ), outperforming 1165 high performance commercial low-e glass. This radiative warming glass holds the promise of making a significant contribution to sustainable building energy savings specifically for high-latitude cold regions, advancing the goal of carbon neutrality.}, archive = {J_ADVS}, author = {Zhengui Zhou and Rong Liu and Zhen Huang and Bin Hu and Yi Long}, doi = {10.1002/advs.202414192}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414192}, shortjournal = {Adv. Sci.}, title = {Radiative warming glass for high-latitude cold regions}, volume = {12}, year = {2025}, }
• (2025). N-oxide-functionalized bipyridines as strong electron-deficient units to construct high-performance n-type conjugated polymers. ADVS, 12(9), 2414059. (www)

  @article{ , abstract = {Developing low-cost unipolar n-type organic thin-film transistors (OTFTs) is necessary for logic circuits. To achieve this objective, the usage of new electron-deficient building blocks with simple structure and easy synthetic route is desirable. Among all electron-deficient building units, N -oxide-functionalized bipyridines can be prepared through a simple oxidized transformation of bipyridines. However, employing N -oxide-functionalized bipyridines as the building unit to construct efficient N-type polymers has been overlooked. This gap strongly encourages us to design and synthesize two new N -oxide building blocks, 5,5'-dibromo-[2,2'-bipyridine] 1-oxide (BPyO) and 5,5'-dibromo-[2,2'-bipyridine] 1,1'-dioxide (BPyDO), through the oxidation of sp 2 - N in 2,2ʹ-bipyridine. The single-crystal X-ray diffraction shows that BPyO and BPyDO possess planar structure with strong π-stacking, which is beneficial for charge transport. Incorporation of these building blocks into acceptor–acceptor backbones leads to two new polymers, namely P(DPP-BPyO) and P(DPP-BPyDO). Both P(DPP-BPyO) and P(DPP-BPyDO) possess lower frontier molecular orbital energy levels than the non-oxide polymer P(DPP-BPy). Consequently, the transition from P(DPP-BPy) (without oxide group) to P(DPP-BPyO) (mono-oxide group) and then to P(DPP-BPyDO) (dioxide group) can decrease hole-transport performance and gradually switch the transport nature from p-type to n-type via ambipolar. These results prove that the introduction of sp 2 - N oxide groups in building units would be a promising strategy to approach high-performance n-type polymers.}, archive = {J_ADVS}, author = {Mingwei Li and Wenhao Li and Junkang Zhou and Xiaowen Tian and Hongxiang Li and Zhen Jiang and Di Liu and Yunqi Liu and Yang Wang and Yongqiang Shi}, doi = {10.1002/advs.202414059}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2414059}, shortjournal = {Adv. Sci.}, title = {N-oxide-functionalized bipyridines as strong electron-deficient units to construct high-performance n-type conjugated polymers}, volume = {12}, year = {2025}, }
• (2025). Facile ester-based phase change materials synthesis for enhanced energy storage toward battery thermal management. ADVS, 12(9), 2413703. (www)

  @article{ , abstract = {With the increasing demand for thermal management, phase change materials (PCMs) have garnered widespread attention due to their unique advantages in energy storage and temperature regulation. However, traditional PCMs present challenges in modification, with commonly used physical methods facing stability and compatibility issues. This study introduces a simple and effective chemical method by synthesizing seven ester-based PCMs through chemical reactions involving lauric acid (LA) and seven different alcohols. These materials notably broaden the phase change temperature range, exhibiting melting temperature from −8.99 to 46.60 °C, expanding by 203.18% compared to raw alcohol materials. In addition, these samples exhibit excellent thermal stability and high latent heat, with a maximum latent heat value of 182.98 J g −1 . In subsequent application studies, this material demonstrates outstanding energy storage characteristics and proposed an innovative thermal management method for batteries based on the PCM immersion technique, allowing the battery to maintain a temperature below 60 °C for 20.5 h, while the blank group rapidly reached 60 °C within 0.82 h and increased to 75 °C within 2.35 h. This approach greatly improves temperature regulation, enhances battery safety, and boosts operational efficiency, highlighting the immense potential of the material in advanced energy storage applications.}, archive = {J_ADVS}, author = {Long Geng and Kaifeng Luo and Yixuan Lin and Guo Li and Yitong Cao and Jiateng Zhao and Changhui Liu}, doi = {10.1002/advs.202413703}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2413703}, shortjournal = {Adv. Sci.}, title = {Facile ester-based phase change materials synthesis for enhanced energy storage toward battery thermal management}, volume = {12}, year = {2025}, }
• (2025). Bottom–Up metasurfaces for biotechnological applications. ADVS, 12(9), 2413679. (www)

  @article{ , abstract = {Metasurfaces are the 2D counterparts of metamaterials, and their development is accelerating rapidly in the past years. This progress enables the creation of devices capable of uniquely manipulating light, with applications ranging from optical communications to remote biosensing. Metasurfaces are engineered by rational assembly of subwavelength elements, defined as meta-atoms, giving rise to unique physical properties arising from the collective behavior of meta-atoms. These meta-atoms are typically organized using effective, reproducible, and precise nanofabrication methods that require a lot of effort to achieve scalable and cost-effective metasurfaces. In contrast, bottom–up methods based on colloidal nanoparticles (NPs) have developed in the last decade as a fascinating alternative for accelerating the technological spread of metasurfaces. The present review takes stock of recent advances in the fabrication and applications of hybrid metasurfaces prepared by bottom-up methods, resulting in disordered metasurfaces. In particular, metasurfaces prepared with plasmonic NPs are emphasized for their multifold applications, which are discussed from a biotechnology perspective. However, some examples of organized metasurfaces prepared by merging bottom–up and top–down approaches are also described. Finally, leveraging the historical disordered metasurface evolution, the review draws new perspectives for random metasurface design and applications.}, archive = {J_ADVS}, author = {Francesca Petronella and Federica Zaccagnini and Maria Laura Sforza and Vincenzo De Mei and Luciano De Sio}, doi = {10.1002/advs.202413679}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2413679}, shortjournal = {Adv. Sci.}, title = {Bottom–Up metasurfaces for biotechnological applications}, volume = {12}, year = {2025}, }
• (2025). Redox-active Co(II) and Zn(II) pincer complexes as high-capacity anode materials for lithium-ion batteries. ADVS, 12(9), 2413656. (www)

  @article{ , abstract = {To address the ongoing demand for high-performance energy storage devices, it is crucial to identify new electrode materials. Lithium-ion batteries (LIBs) store energy via the electrochemical redox process, so their electrode materials should have reversible redox properties for rechargeability. On that note, redox-active metal complexes are explored as innovative electrode materials for LIBs. Redox-active metal(II) chloride complexes (MCC) demonstrate promising potential as anode materials, exhibiting high capacity and excellent rate capability. In particular, zinc(II) chloride complexes, referred to as ZCC, achieve a capacity of 1720 mAh g −1 at 2.0 A g −1 over 200 cycles. Additionally, the lithium-ion storage mechanism of MCC is elucidated using ex situ analyses of MCC anode's surface in its fully discharged state. The high capacity of the MCC anode is attributed to conversion reaction with Li + ions forming LiCl and electrodeposition of metallic lithium from the over-lithiated Li + ions. These findings support the potential use of redox-active metal complexes as novel anode materials for LIBs.}, archive = {J_ADVS}, author = {Honggyu Seong and Joon Ha Moon and Youngho Jin and Geongil Kim and Taejung Jung and Hyerin Yoo and Woonghee Lee and Kyounghoon Lee and Se Youn Cho and Jaewon Choi}, doi = {10.1002/advs.202413656}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2413656}, shortjournal = {Adv. Sci.}, title = {Redox-active Co(II) and Zn(II) pincer complexes as high-capacity anode materials for lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). 3D femtosecond laser beam deflection for high-precision fabrication and modulation of individual voxelated PCM meta-atoms. ADVS, 12(9), 2413316. (www)

  @article{ , abstract = {Optical metasurfaces have found widespread applications in the field of optoelectronic devices. However, achieving dynamic and flexible control over metasurface functionalities, while also developing simplified fabrication methods for metasurfaces, continues to pose a significant challenge. Here, the study introduces a PCM-only metasurface that exclusively consists of voxel units crafted from different phases of phase-change materials. Micro-nano regions, with varying phase states, are directly utilized as resonant elements and embedded in the material, forming the metasurface voxel meta-atoms. By manipulating the morphology, size, and arrangement of these meta-atoms, the study achieves both the fabrication and modulation of the PCM-only metasurface. Additionally, a 3D high-precision voxelated beam deflection method based on femtosecond laser phase modulation is introduced to streamline the fabrication and modulation of PCM-only metasurface. By using a spatial light modulator to load the blazed grating phase manipulation beam for precise deflection, high-precision deflection processing of individual meta-atom on metasurfaces can be achieved, with a deflection accuracy of up to 200nm. By loading Fresnel phase manipulation beams to move along the z-axis, perfect modulation of PCM sub-meta-atoms can be achieved. The 3D femtosecond laser beam deflection technology will bring many potential application opportunities in the fields of optoelectronic device fabrication and functional control.}, archive = {J_ADVS}, author = {Weina Han and Donghui Wei and Biye Peng and Jianhui Jiang and Jintao Tong and Zhehao Xu and Xueyan Zou and Jie Hu and Qian Cheng and Lan Jiang}, doi = {10.1002/advs.202413316}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2413316}, shortjournal = {Adv. Sci.}, title = {3D femtosecond laser beam deflection for high-precision fabrication and modulation of individual voxelated PCM meta-atoms}, volume = {12}, year = {2025}, }
• (2025). Catalytic hydrolysis of perfluorinated compounds in a Yolk–Shell micro-reactor. ADVS, 12(9), 2413203. (www)

  @article{ , abstract = {Perfluorinated compounds (PFCs) are emerging environmental pollutants characterized by their extreme stability and resistance to degradation. Among them, tetrafluoromethane (CF 4 ) is the simplest and most abundant PFC in the atmosphere. However, the highest C─F bond energy and its highly symmetrical structure make it particularly challenging to decompose. In this work, a yolk–shell Al 2 O 3 micro-reactor is developed to enhance the catalytic hydrolysis performance of CF 4 by creating a local autothermic environment. Finite element simulations predict that the yolk–shell Al 2 O 3 micro-reactor captures the heat released during the catalytic hydrolysis of CF 4 , resulting in a local autothermic environment within the yolk–shell structure that is 50 °C higher than the set temperature. The effectiveness of this local autothermic environment is experimentally confirmed by in situ Raman spectroscopy. As a result, the obtained yolk–shell Al 2 O 3 micro-reactor achieves 100% CF 4 conversion at a considerably low temperature of 580 °C for over 150 h, while hollow and solid Al 2 O 3 structures required higher temperatures of 610 and 630 °C, respectively, to achieve the same conversion rate, demonstrating the potential of yolk–shell Al 2 O 3 micro-reactor to significantly reduce the energy requirements for PFCs degradation and contribute to more sustainable and effective environmental remediation strategies.}, archive = {J_ADVS}, author = {Jialin Zheng and Xiaojian Wang and Xin Zi and Hang Zhang and Heping Chen and Evangelina Pensa and Kang Liu and Junwei Fu and Zhang Lin and Liyuan Chai and Emiliano Cortés and Min Liu}, doi = {10.1002/advs.202413203}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2413203}, shortjournal = {Adv. Sci.}, title = {Catalytic hydrolysis of perfluorinated compounds in a Yolk–Shell micro-reactor}, volume = {12}, year = {2025}, }
• (2025). Operando X-ray tomoscopy of laser beam welding. ADVS, 12(9), 2413108. (www)

  @article{ , abstract = {The phenomena occurring in a weld seam during advancement of a laser beam over a metallic component are still under dispute. The occurrence and evolution of porosity and the occasional blowout of melt need to be understood. Here, a recently developed X-ray tomoscopy setup is applied, providing one hundred 3D images per second to capture the temporal evolution of the melt pool in an AlSi9Cu3(Fe) die-casting while a laser beam advances. The number of pores, their size, shape and distribution are quantified with 10 ms time resolution and reflect a complex dynamic pattern. Apart from conventional welding, a variant involving a dynamic beam modulation superimposed onto the linear motion is studied. Reductions of porosity and surface roughness are observed and explained by increased pore mobility and stepwise degassing as the beam repeatedly cuts through pores. The keyhole formed in the melt pool integrated over 10 ms is represented in 3D.}, archive = {J_ADVS}, author = {Paul Hans Kamm and Stephan Börner and Tillmann Robert Neu and Christian Matthias Schlepütz and Dirk Dittrich and John Banhart and Francisco García-Moreno}, doi = {10.1002/advs.202413108}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2413108}, shortjournal = {Adv. Sci.}, title = {Operando X-ray tomoscopy of laser beam welding}, volume = {12}, year = {2025}, }
• (2025). Electron-rich heptacyclic S,N heteroacene enabling C-shaped A-D-A-type electron acceptors with photoelectric response beyond 1000 nm for highly sensitive near-infrared photodetectors. ADVS, 12(9), 2413045. (www)

  @article{ , abstract = {A highly electron-rich S,N heteroacene building block is developed and condensed with FIC and Cl-IC acceptors to furnish CT-F and CT-Cl, which exhibit near-infrared (NIR) absorption beyond 1000 nm. The C-shaped CT-F and CT-Cl self-assemble into a highly ordered 3D intermolecular packing network via multiple π−π interactions in the single crystal structures. The CT-F-based organic photovoltaic (OPV) achieved an impressive efficiency of 14.30% with a broad external quantum efficiency response extending from the UV-vis to the NIR (300–1050 nm) regions, outperforming most binary OPVs employing NIR A-D-A-type acceptors. CT-Cl possesses a higher surface energy than CT-F, promoting vertical phase segregation and resulting in its preferential accumulation near the bottom interface of the blend. This arrangement, combined with the lower HOMO energy level of CT-Cl, effectively reduces undesired hole and electron injection under reverse voltage. The PM6:CT-Cl-based organic photodetectors (OPDs) devices achieved an ultra-high shot-noise-limited specific detectivity ( D sh *) values exceeding 10 14 Jones in the NIR region from 620 to 1000 nm, reaching an unprecedentedly high value of 1.3 × 10 14 Jones at 950 nm. When utilizing a 780 nm light source, the PM6:CT-Cl-based OPDs show record-high rise/fall times of 0.33/0.11 µs and an exceptional cut-off frequency ( f -3dB ) of 590 kHz at −1 V.}, archive = {J_ADVS}, author = {Kuo-Hsiu Huang and Bing-Huang Jiang and Han-Cheng Lu and Yung-Jing Xue and Chia-Fang Lu and Yung-Yung Chang and Ching-Li Huang and Su-Ying Chien and Chih-Ping Chen and Yen-Ju Cheng}, doi = {10.1002/advs.202413045}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2413045}, shortjournal = {Adv. Sci.}, title = {Electron-rich heptacyclic S,N heteroacene enabling C-shaped A-D-A-type electron acceptors with photoelectric response beyond 1000 nm for highly sensitive near-infrared photodetectors}, volume = {12}, year = {2025}, }
• (2025). Scale-free spatio-temporal correlations in conformational fluctuations of intrinsically disordered proteins. ADVS, 12(9), 2412989. (www)

  @article{ , abstract = {The self-assembly of intrinsically disordered proteins (IDPs) into condensed phases and the formation of membrane-less organelles (MLOs) can be considered as the phenomenon of collective behavior. The conformational dynamics of IDPs are essential for their interactions and the formation of a condensed phase. From a physical perspective, collective behavior and the emergence of phase are associated with long-range correlations. Here the conformational dynamics of IDPs and the correlations therein are analyzed, using µs-scale atomistic molecular dynamics (MD) simulations and single-molecule Förster resonance energy transfer (smFRET) experiments. The existence of typical scale-free spatio-temporal correlations in IDP conformational fluctuations is demonstrated. Their conformational evolutions exhibit “1/ f noise” power spectra and are accompanied by the appearance of residue domains following a power-law size distribution. Additionally, the motions of residues present scale-free behavioral correlation. These scale-free correlations resemble those in physical systems near critical points, suggesting that IDPs are poised at a critical state. Therefore, IDPs can effectively respond to finite differences in sequence compositions and engender considerable structural heterogeneity which is beneficial for IDP interactions and phase formation.}, archive = {J_ADVS}, author = {Haoyu Song and Jian Cui and Guorong Hu and Long Xiong and Yanee Wutthinitikornkit and Hai Lei and Jingyuan Li}, doi = {10.1002/advs.202412989}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412989}, shortjournal = {Adv. Sci.}, title = {Scale-free spatio-temporal correlations in conformational fluctuations of intrinsically disordered proteins}, volume = {12}, year = {2025}, }
• (2025). Rescuing ACE2-deficiency-mediated nucleus pulposus senescence and intervertebral disc degeneration by a nanotopology-enhanced RNAi system. ADVS, 12(9), 2412908. (www)

  @article{ , abstract = {Nucleus pulposus cell (NPC) senescence contributes to intervertebral disc degeneration (IVDD). However, the underlying molecular mechanisms are not fully understood. In this study, it is demonstrated that angiotensin-converting enzyme 2 (ACE2) counteracted the aging of NPCs and IVDD at the cellular and physiological levels. The expression of ACE2 correlates negatively with the degree of NPC senescence and IVDD. Using both loss- and gain-of-function mouse models, it is revealed that ACE2 deficiency increased the senescence of NPCs and exacerbated injury- or instability-induced IVDD, whereas ACE2 overexpression counteracted these detrimental effects. Mechanistically, integrated analysis of single-cell and bulk transcriptomics shows that ACE2 deficiency results in the activation of TGFβ2/Smads signaling pathway and the transcription of Serpine1, ultimately triggering NPC senescence and IVDD. A nanomedical delivery system (virus-like nanovectors, VNs) composed of nanovectors with a virus-like surface topology and small interfering RNA targeting Serpine1 (VN-siSer) is developed. With nanotopology-enhanced transfection efficiency, RNA-interfering treatment by VN-siSer effectively alleviated NPC senescence and IVDD at both the cellular and animal levels. Overall, the data reveal the underlying mechanisms of ACE2 in NPC senescence and IVDD pathogenesis and propose a distinct paradigm of precise nanomedical senescence-blockade RNAi for IVDD treatment.}, archive = {J_ADVS}, author = {Kaiqiang Sun and Zijian Kang and Chen Yan and Yan Yu and Linhui Han and Yangyang Shi and Liang Chen and Jiangang Shi and Yu Chen and Jingchuan Sun}, doi = {10.1002/advs.202412908}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412908}, shortjournal = {Adv. Sci.}, title = {Rescuing ACE2-deficiency-mediated nucleus pulposus senescence and intervertebral disc degeneration by a nanotopology-enhanced RNAi system}, volume = {12}, year = {2025}, }
• (2025). Meta-device for field-of-view tunability via adaptive optical spatial differentiation. ADVS, 12(9), 2412794. (www)

  @article{ , abstract = {Optical edge detection is a crucial optical analog computing method in fundamental artificial intelligence, machine vision, and image recognition, owing to its advantages of parallel processing, high computing speed, and low energy consumption. Field-of-view-tunable edge detection is particularly significant for detecting a broader range of objects, enhancing both practicality and flexibility. In this work, a novel approach—adaptive optical spatial differentiation is proposed for field-of-view-tunable edge detection. This method improves the ability to acquire spatial information and facilitates edge detection over a wider angular range. The adaptive optical spatial differentiation meta-device relies on two core components: the spatial differentiation dielectric metasurface and the adaptive liquid prism. The meta-device is shown to function as a highly efficient (≈85%) isotropic spatial differentiator, operating across the entire visible spectrum (400 to 700 nm) within a wide-angle object space, expanding up to 4.5 times the original field of view. The proposed scheme presents new opportunities for efficient, flexible, high-capacity integrated data processing and imaging devices. And simultaneously provides a novel optical analog computing architecture for the next generation of wide field-of-view phase contrast microscopy.}, archive = {J_ADVS}, author = {Yin Zhou and Lin Li and Junhao Zhang and Jialuo Cheng and Xiaoyuan Liu and Yunhui Gao and Zihan Geng and Lei Li and Junxiao Zhou and Mu Ku Chen}, doi = {10.1002/advs.202412794}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412794}, shortjournal = {Adv. Sci.}, title = {Meta-device for field-of-view tunability via adaptive optical spatial differentiation}, volume = {12}, year = {2025}, }
• (2025). Aspergillus mycotoxins: The major food contaminants. ADVS, 12(9), 2412757. (www)

  @article{ , abstract = {Mycotoxins, a category of fungal secondary metabolites, frequently contaminate food products and pose a severe threat to human health. Aspergillus , a genus of fungi, is capable of producing mycotoxins, with aflatoxins (AFs) and ochratoxins being its principal types. Aspergillus mycotoxins can contaminate a wide range of crops and their derivatives, such as maize, wheat, rice, minor cereals, and peanuts, thereby threatening food and feed safety. In the paper, the related biosynthesis genes and multifaceted biosynthesis pathways of these mycotoxins are first discussed in detail, and elucidated several global regulators, including growth conditions, oxidative stress, and cell signal. Furthermore, how global shifts in temperature and water availability, driven by climate change (including rising temperatures, increased heavy rainfall frequency, prolonged droughts, and elevated carbon dioxide levels), are key determinants of Aspergillus proliferation and mycotoxin production are explored. Finally, to safeguard animal and human health from the detrimental impacts of Aspergillus mycotoxins, the effective and convenient analytical techniques and management strategies for the detection and prevention of contamination are analyzed. Overall, this review provides effective detection techniques and promising solutions to the global contamination of food with Aspergillus mycotoxins, which is of great significance to ensuring food security and protecting people's lives and health.}, archive = {J_ADVS}, author = {Mengyao Xue and Zheng Qu and Antonio Moretti and Antonio F. Logrieco and Haiyan Chu and Qi Zhang and Changpo Sun and Xianfeng Ren and Li Cui and Qinglin Chen and Yi An and Chengjun Li and Huan Zhong and Zhiyan Cao and Feng Wang and Yuebing Sun and Lili Wang and Jie Hou and Chenchen Zhang and Mengmeng Yang and Yiming Ding and Yanpo Yao and Peiwu Li and Yong-Guan Zhu}, doi = {10.1002/advs.202412757}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412757}, shortjournal = {Adv. Sci.}, title = {Aspergillus mycotoxins: The major food contaminants}, volume = {12}, year = {2025}, }
• (2025). Photothermal effect and biomineralization of black phosphorus nanosheet-composited hydrogel boosts synergistic treatment of dentin hypersensitivity. ADVS, 12(9), 2412561. (www)

  @article{ , abstract = {Dentin hypersensitivity (DH), marked by exposed dentinal tubules, presents as a sharp toothache triggered by stimuli and subsides when the stimuli are removed. To address the limitations of current commercial desensitizers in terms of acid resistance, friction resistance, and stability, a black phosphorus nanosheet-composited methacrylate gelatin hydrogel (GelMA/BP) is developed for DH treatment, leveraging the synergistic effects of photothermal therapy and biomineralization. Incorporating the BP nanosheet provided GelMA/BP with a stable photothermal response and the continuous release of phosphate anions, which blocked dentinal tubules by converting light energy into heat and initiating biomineralization. In vitro desensitizing therapy showed that the dentinal tubule diameter in the GelMA/BP50 group (0−1.13 µm) is significantly reduced compared to that in the DH-model group (0−3.14 µm). The GelMA/BP50 group achieved an 86% tubule occlusion rate, with acid resistance of 80%, friction resistance of 76%, and long-term stability of 74%. In vivo studies further validated the efficacy of GelMA/BP50, showing a reduction in tubule diameter (0−0.37 µm) and an occlusion rate of 79%, which alleviated toothache and increased intake and weight. These results demonstrate that this desensitizing hydrogel acts as an effective dentinal tubule sealant, offering promising clinical benefits for the topical treatment of DH.}, archive = {J_ADVS}, author = {Qihui Wang and Guoliang Wang and Xinru Li and Di Li and Congxiao Zhang and Jianxun Ding}, doi = {10.1002/advs.202412561}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412561}, shortjournal = {Adv. Sci.}, title = {Photothermal effect and biomineralization of black phosphorus nanosheet-composited hydrogel boosts synergistic treatment of dentin hypersensitivity}, volume = {12}, year = {2025}, }
• (2025). M6A demethyltransferase FTO attenuates meniscus degeneration and osteoarthritis via orchestrating autophagy and energetic metabolism. ADVS, 12(9), 2412379. (www)

  @article{ , abstract = {Impaired autophagy is reported to promote osteoarthritis (OA). However, the mechanism by which autophagy in regulating meniscus degeneration and OA remains unclear. Here, unconvered aberrant energetic metabolism pattern in meniscus cells with OA is uncovered first, which results in lower adenosine triphosphate (ATP) production. And these phenomena are induced by impaired autophagy in meniscus cells with OA. It is further revealed that the suppression of m 6 A demethylase fat mass and obesity-associated protein (FTO) inhibits autophagy and causing lower ATP production by reducing oxidative phosphorylation. Specific deletion of FTO in meniscus cells by generating FTO flox/flox ; COL1A1-Cre ERT2 (FTO cko ) mice impair autophagy and promote meniscus degeneration and OA, while intra-articular injection of adeno-associated virus of FTO (AAV-FTO) restores autophagy and alleviates meniscus degeneration and OA. Mechanistically, FTO regulates the mRNA stability of ATG16L1 by targeting the m 6 A methylation sites on ATG16L1 in a YTHDF2-dependent manner, thereby inhibiting the formation of autophagosomes and causing an imbalance in energetic metabolism. Intra-articular injection of AAV-FTO reverses the catabolic phenotype of meniscus degeneration and OA in FTO cko mice. In summary, these findings reveal FTO orchestrates autophagy and energetic metabolism by regulating ATG16L1 in a m 6 A-dependent manner. Therefore, targeting FTO might be a potential therapeutic strategy for meniscus degeneration and early-stage OA.}, archive = {J_ADVS}, author = {Zongrui Jiang and Chengyun Zhang and Ruonan Liu and Zijing Zhu and Dianbo Long and Xingzhao Wen and Zhijian Yang and Dong Jiang and Guping Mao and Weiming Liao and Zhiqi Zhang}, doi = {10.1002/advs.202412379}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412379}, shortjournal = {Adv. Sci.}, title = {M6A demethyltransferase FTO attenuates meniscus degeneration and osteoarthritis via orchestrating autophagy and energetic metabolism}, volume = {12}, year = {2025}, }
• (2025). Reversing cochlear nucleus maladaptive plasticity via customized extracochlear stimulation: A new approach for tinnitus treatment. ADVS, 12(9), 2412349. (www)

  @article{ , abstract = {Tinnitus, a widespread condition affecting numerous individuals worldwide, remains a significant challenge due to limited effective therapeutic interventions. Intriguingly, patients using cochlear implants (CIs) have reported significant relief from tinnitus symptoms, although the underlying mechanisms remain unclear and intracochlear implantation risks cochlear damage and hearing loss. This study demonstrates that targeted intracochlear electrical stimulation (ES) in guinea pigs with noise-induced hearing loss reversed tinnitus-related maladaptive plasticity in the cochlear nucleus (CN), characterized by reduced auditory innervation, increased somatosensory innervation, and diminished inhibitory neural networks. Additionally, a customized extracochlear ES delivered by a newly designed extracochlear electrode array to guinea pigs with salicylate-induced tinnitus also reversed the aforementioned maladaptive plasticity and alleviated tinnitus without causing additional cochlear damage or hearing loss. These findings suggest that CI-delivered ES may alleviate tinnitus by reversing maladaptive CN plasticity. Additionally, the extracochlear ES strategy offers a promising tinnitus treatment with minimal risk to hearing.}, archive = {J_ADVS}, author = {Min Chen and Shuwen Fan and Jiabao Mao and Linhan Huang and Nafisa Tursun and Chen Zhang and Wen Li and Shufeng Li}, doi = {10.1002/advs.202412349}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412349}, shortjournal = {Adv. Sci.}, title = {Reversing cochlear nucleus maladaptive plasticity via customized extracochlear stimulation: A new approach for tinnitus treatment}, volume = {12}, year = {2025}, }
• (2025). Skin-integrated electrogenetic regulation of vasculature for accelerated wound healing. ADVS, 12(9), 2412257. (www)

  @article{ , abstract = {Neo-vascularization plays a key role in achieving long-term viability of engineered cells contained in medical implants used in precision medicine. Moreover, strategies to promote neo-vascularization around medical implants may also be useful to promote the healing of deep wounds. In this context, a biocompatible, electroconducti v e b o rophene–poly(ε-capro l ac t one) (PCL) 3D platform is developed, which is called VOLT, to support designer cells engineered with a direct-current (DC) voltage-controlled gene circuit that drives secretion of vascular endothelial growth factor A (VEGFA). The VOLT platform consists of a 3D-printed borophene-PCL honeycomb-shaped matrix decorated with borophene-PCL nanofibers by electrospinning. The honeycomb structure provides mechanical stability, while the nanofibers facilitate the adhesion, migration, and proliferation of the engineered cells. The cells incorporate a DC-powered reactive oxygen species (ROS)-sensing gene circuit wired to an engineered synthetic promoter that triggers secretion of VEGFA to promote vascularization in the adjacent extracellular matrix. Cells engineered with this gene circuit and enclosed in the VOLT matrix, termed the VOLT VEGFA system, can be simply triggered using off-the-shelf AA batteries, utilizing the established ability of a brief DC bias to generate non-cytotoxic levels of ROS. For proof-of-concept, a subcutaneous wound-healing model in rats is chosen. Electrostimulation of a VOLT VEGFA implant (5 V, 20 s per day) induced secretion of VEGFA, and significantly accelerated neovascularization and granulation tissue formation, resulting in faster wound closure compared with non-stimulated controls. Complete re-epithelialization and dermal regeneration are observed within 15 days of application.}, archive = {J_ADVS}, author = {Preetam Guha Ray and Ragavi Rajasekaran and Bitan Pratihar and Sirshendu De and Santanu Dhara and Martin Fussenegger}, doi = {10.1002/advs.202412257}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412257}, shortjournal = {Adv. Sci.}, title = {Skin-integrated electrogenetic regulation of vasculature for accelerated wound healing}, volume = {12}, year = {2025}, }
• (2025). Single-cell hi-C technologies and computational data analysis. ADVS, 12(9), 2412232. (www)

  @article{ , abstract = {Single-cell chromatin conformation capture (scHi-C) techniques have evolved to provide significant insights into the structural organization and regulatory mechanisms in individual cells. Although many scHi-C protocols have been developed, they often involve intricate procedures and the resulting data are sparse, leading to computational challenges for systematic data analysis and limited applicability. This review provides a comprehensive overview, quantitative evaluation of thirteen protocols and practical guidance on computational topics. It is first assessed the efficiency of these protocols based on the total number of contacts recovered per cell and the cis/trans ratio. It is then provided systematic considerations for scHi-C quality control and data imputation. Additionally, the capabilities and implementations of various analysis methods, covering cell clustering, A/B compartment calling, topologically associating domain (TAD) calling, loop calling, 3D reconstruction, scHi-C data simulation and differential interaction analysis is summarized. It is further highlighted key computational challenges associated with the specific complexities of scHi-C data and propose potential solutions.}, archive = {J_ADVS}, author = {Madison A Dautle and Yong Chen}, doi = {10.1002/advs.202412232}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412232}, shortjournal = {Adv. Sci.}, title = {Single-cell hi-C technologies and computational data analysis}, volume = {12}, year = {2025}, }
• (2025). Engineered microneedle system enables the smart regulation of nanodynamic sterilization and tissue regeneration for wound management. ADVS, 12(9), 2412226. (www)

  @article{ , abstract = {The healing of bacterial biofilm-infected wounds is a complex process, and the construction of emerging therapeutic modalities that regulate the microenvironment to magnify therapeutic effects and reduce biotoxicity is still highly challenging. Herein, an engineered microneedle (MN) patch is reported to mediate the efficient delivery of black phosphorus nanosheets (BP NSs) and copper peroxide nanodots (CP NDs) for dual nanodynamic sterilization and methicillin-resistant staphylococcus aureus (MRSA)-infected wound healing. Results demonstrate that the system can eliminate biofilm, reduce cytotoxicity, promote angiogenesis and tissue regeneration by the multiple advantages of chemodynamic therapy (CDT), enhanced photodynamic therapy (PDT), and improved degradation process from BP NSs to phosphate for promoting cell proliferation. Notably, the balance between excellent photodynamic stability and rapid degradability of BP NSs is maintained, and the improved degradation mechanism of BP NSs is vividly elucidated by density functional theory (DFT)-based molecular dynamics (MD) calculations. Furthermore, the transcriptional changes of treated MRSA-infected skin are studied using RNA-seq technology to reveal the potential therapeutic mechanism. As envisaged, the proposed MN patch provides a safe, easy, also highly effective approach to achieve the temporal regulation of sterilization and tissue regeneration for bacterial biofilm-infected wounds.}, archive = {J_ADVS}, author = {Shiyang Lin and Zhongqi Cui and Qingqiong Luo and Chen Li and Yue Zhang and Fengjiao Yang and Yichuan Chen and Chuansheng Xu and Yan Gao and Shasha Zhao and Fenyong Sun and Dandan Shen and Qi Wu and Shuo Shi}, doi = {10.1002/advs.202412226}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412226}, shortjournal = {Adv. Sci.}, title = {Engineered microneedle system enables the smart regulation of nanodynamic sterilization and tissue regeneration for wound management}, volume = {12}, year = {2025}, }
• (2025). Decoding the implications of zinc in the development and therapy of leukemia. ADVS, 12(9), 2412225. (www)

  @article{ , abstract = {Zinc plays a central role in the hematological development. Therapeutic interventions with zinc are shown to improve the health status of patients with malignancies by stimulating the immune system and reducing side effects. Despite the abnormal zinc homeostasis in leukemia, the role and mechanisms of zinc signaling in leukemia development remain poorly understood. Recently, some important breakthroughs are made in laboratory and clinical studies of zinc in leukemia, such as the role of zinc in regulating ferroptosis and the effects of zinc in immunotherapy. Zinc-based strategies are urgently needed to refine the current zinc intervention regimen for side-effect free therapy in chemotherapy-intolerant patients. This review provides a comprehensive overview of the role of zinc homeostasis in leukemia patients and focuses on the therapeutic potential of zinc signaling modulation in leukemia.}, archive = {J_ADVS}, author = {Bo Zhu and Chunhao Yang and Siqi Hua and Kaiqiang Li and Pengyou Shang and Zhonghua Li and Wei Qian and Shunkang Xue and Qi Zhi and Zichun Hua}, doi = {10.1002/advs.202412225}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412225}, shortjournal = {Adv. Sci.}, title = {Decoding the implications of zinc in the development and therapy of leukemia}, volume = {12}, year = {2025}, }
• (2025). Spatiotemporal dynamic immunomodulation by infection-mimicking gels enhances broad and durable protective immunity against heterologous viruses. ADVS, 12(9), 2412116. (www)

  @article{ , abstract = {Despite their safety and widespread use, conventional protein antigen-based subunit vaccines face significant challenges such as low immunogenicity, insufficient long-term immunity, poor CD8 + T-cell activation, and poor adaptation to viral variants. To address these issues, an infection-mimicking gel (IM-Gel) is developed that is designed to emulate the spatiotemporal dynamics of immune stimulation in acute viral infections through in situ supramolecular self-assembly of nanoparticulate-TLR7/8a (NP-TLR7/8a) and an antigen with tannic acid (TA). Through collagen-binding properties of TA, the IM-Gel enables sustained delivery and enhanced retention of NP-TLR7/8a and protein antigen in the lymph node subcapsular sinus of mice for over 7 days, prolonging the exposure of vaccine components in both B cell and T cell zones, leading to robust humoral and cellular responses. The IM-Gel system with the influenza A antigen confers cross-protection against multiple influenza subtypes (H1N1, H5N2, H3N2, H7N3, and H9N2) with long-term immune responses. Combination of the IM-Gel with the SARS-CoV-2 spike protein also elicits strong cross-reactive antibody responses against multiple SARS-CoV-2 variants (Alpha, Beta, NY510+D614G, Gamma, Kappa, and Delta). The IM-Gel, as a programmable immunomodulatory material, provides a vaccine design principle for the development of next-generation universal vaccines that can elicit broad and durable protective immunity against emerging viruses.}, archive = {J_ADVS}, author = {Seung Mo Jin and Ju Hee Cho and Yebin Seong and Wijesinghe Arachchilage Gayan Chathuranga and Yejin Gwak and Young-Woock Noh and Min-Ho Lee and Sang-Seok Oh and Jin-Ho Choi and Jong-Soo Lee and Yong Taik Lim}, doi = {10.1002/advs.202412116}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2412116}, shortjournal = {Adv. Sci.}, title = {Spatiotemporal dynamic immunomodulation by infection-mimicking gels enhances broad and durable protective immunity against heterologous viruses}, volume = {12}, year = {2025}, }
• (2025). Maternal gut inflammation aggravates acute liver failure through facilitating ferroptosis via altering gut microbial metabolism in offspring. ADVS, 12(9), 2411985. (www)

  @article{ , abstract = {Microbial transmission from mother to infant is important for offspring microbiome formation and health. However, it is unclear whether maternal gut inflammation (MGI) during lactation influences mother-to-infant microbial transmission and offspring microbiota and disease susceptibility. In this study, it is found that MGI during lactation altered the gut microbiota of suckling pups by shaping the maternal microbiota in the gut and mammary glands. MGI-induced changes in the gut microbiota of suckling pups lasted into adulthood, resulting in the exacerbation of acute liver failure (ALF) caused by acetaminophen (APAP) in offspring. Specifically, MGI reduced the abundance of Lactobacillus reuteri ( L. reuteri ) and its metabolite indole-3-acetic acid (IAA) level in adult offspring. L. reuteri and IAA alleviated ALF in mice by promoting intestinal IL-22 production. Mechanistically, IL-22 limits APAP-induced excessive oxidative stress and ferroptosis by activating STAT3. The intestinal abundances of L. reuteri and IAA are inversely associated with the progression of patients with ALF. Overall, the study reveals the role of MGI in mother-to-infant microbial transmission and disease development in offspring, highlighting potential strategies for intervention in ALF based on the IAA-IL-22-STAT3 axis.}, archive = {J_ADVS}, author = {Caijun Zhao and Lijuan Bao and Ruping Shan and Yihong Zhao and Keyi Wu and Shan Shang and Haiqi Li and Yi Liu and Ke Chen and Naisheng Zhang and Cong Ye and Xiaoyu Hu and Yunhe Fu}, doi = {10.1002/advs.202411985}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411985}, shortjournal = {Adv. Sci.}, title = {Maternal gut inflammation aggravates acute liver failure through facilitating ferroptosis via altering gut microbial metabolism in offspring}, volume = {12}, year = {2025}, }
• (2025). Recent advances in 3D printed electrodes – Bridging the nano to mesoscale. ADVS, 12(9), 2411951. (www)

  @article{ , abstract = {3D architected electrodes offer inherent physicochemical advantages for energy storage, conversion, and sensing. 3D printing methods such as stereolithography and two photon polymerization are uniquely capable of fabricating these architected electrodes with a high degree of geometric complexity impossible to achieve with other methods at the mesoscale (10 µm–1 mm). The material set for 3D printing traditionally is focused on structural materials rather than functional materials suitable for electronic and electrochemical applications. In this review the fundamental challenges are considered for transforming 3D printed materials into conductive, multifunctional electrodes suitable for electrical and electrochemical devices by printing nanocomposites, infusing molecular precursors and post-processing these structures via carbonization. To understand the design of 3D electrodes toward their use in both sensors and electrochemical devices such as catalysts, this review summarizes recent advances in hierarchical design of porous metastructures, the engineering of mass transport and electronic transport in 3D structures, and the application of high-throughput materials design by machine learning and artificial intelligence. These emerging approaches to 3D electrode design and architecture promise to expand the capabilities of additive manufacturing beyond structural materials and bring its advantages to bear on modern devices such as sensors, batteries, supercapacitors, and electrocatalysts.}, archive = {J_ADVS}, author = {William J. Scheideler and Jisun Im}, doi = {10.1002/advs.202411951}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411951}, shortjournal = {Adv. Sci.}, title = {Recent advances in 3D printed electrodes – Bridging the nano to mesoscale}, volume = {12}, year = {2025}, }
• (2025). HCAR2 modulates the crosstalk between mammary epithelial cells and macrophages to mitigate staphylococcus aureus infection in the mouse mammary gland. ADVS, 12(9), 2411947. (www)

  @article{ , abstract = {Staphylococcus aureus ( S. aureus ) is a major zoonotic pathogen, with mammary gland infections contributing to mastitis, a condition that poses significant health risks to lactating women and adversely affects the dairy industry. Therefore, understanding the immune mechanisms underlying mammary infections caused by S. aureus is essential for developing targeted therapeutic strategies against mastitis. This study identified hydroxycarboxylic acid receptor 2 (HCAR2) as a potential regulator of S. aureus infection in mammary glands. It is demonstrated that HCAR2 deficiency exacerbates the inflammatory response and disrupts the blood-milk barrier in the mammary gland during S. aureus infection, with NLRP3 inflammasome-mediated pyroptosis playing a central role. Activation of HCAR2, on the other hand, suppressed CMPK2 expression, thereby mitigating mitochondrial damage and pyroptosis in mouse mammary epithelial cells (mMECs) induced by S. aureus . Additionally, mitochondrial DNA (mtDNA) released from S. aureus -infected mMECs activates the cGAS/STING signaling pathway in macrophages, impairing their bactericidal activity. In conclusion, this study highlights the critical role of HCAR2 in S. aureus infection of the mammary gland and provides a theoretical basis for identifying potential therapeutic targets for such infections.}, archive = {J_ADVS}, author = {Xin Ran and Kefei Li and Yutao Li and Weiwei Guo and Xiaoxuan Wang and Wenjin Guo and Bao Yuan and Juxiong Liu and Shoupeng Fu}, doi = {10.1002/advs.202411947}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411947}, shortjournal = {Adv. Sci.}, title = {HCAR2 modulates the crosstalk between mammary epithelial cells and macrophages to mitigate staphylococcus aureus infection in the mouse mammary gland}, volume = {12}, year = {2025}, }
• (2025). Sequential targeting chondroitin sulfate-bilirubin nanomedicine attenuates osteoarthritis via reprogramming lipid metabolism in m1 macrophages. ADVS, 12(9), 2411911. (www)

  @article{ , abstract = {The infiltration and excessive polarization of M1 macrophages contribute to the induction and persistence of low-grade inflammation in joint-related degenerative diseases such as osteoarthritis (OA). The lipid metabolism dysregulation promotes M1 macrophage polarization by coordinating the compensatory pathways of the inflammatory and oxidative stress responses. Here, a self-assembling, licofelone-loaded nanoparticle (termed LCF-CSBN), comprising chondroitin sulfate and bilirubin joined by an ethylenediamine linker, is developed to selectively reprogram lipid metabolism in macrophage activation. LCF-CSBN is internalized by M1 macrophages via CD44-mediated endocytosis and targets the Golgi apparatus accompanied with the reactive oxygen species-responsive release of licofelone (LCF, dual inhibitor of arachidonic acid metabolism). LCF-CSBN effectively promotes M1 to M2 macrophage transition by reprogramming the Golgi apparatus-related sphingolipid metabolism and arachidonic acid metabolism. Intra-articularly injected LCF-CSBN retains in the joint for up to 28 days and accumulates into M1 macrophages. Moreover, LCF-CSBN can effectively attenuate joint inflammation, oxidative stress, and cartilage degeneration in OA model rats. These findings indicate the promising potential of lipid-metabolism-reprogramming LCF-CSBN in the targeted therapy of OA.}, archive = {J_ADVS}, author = {Caifeng Deng and Yongbing Xiao and Xuan Zhao and Hui Li and Yuxiao Chen and Kelong Ai and Ting Jiang and Jie Wei and Xiaoyuan Chen and Guanghua Lei and Chao Zeng}, doi = {10.1002/advs.202411911}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411911}, shortjournal = {Adv. Sci.}, title = {Sequential targeting chondroitin sulfate-bilirubin nanomedicine attenuates osteoarthritis via reprogramming lipid metabolism in m1 macrophages}, volume = {12}, year = {2025}, }
• (2025). Plasmon-driven gold nanopillar multiarrayed gene amplification methodology for the high-throughput discrimination of pathogens. ADVS, 12(9), 2411849. (www)

  @article{ , abstract = {Molecular diagnosis limitations, including complex treatment processes, low cost-effectiveness, and operator-dependent low reproducibility, interrupt the timely prevention of disease spread and the development of medical devices for home and outdoor uses. A newly fabricated gold nanopillar array-based film is presented for superior photothermal energy conversion. Magnifying the metal film surface-to-volume ratio increases the photothermal energy conversion efficiency, resulting in a swift reduction in the gene amplification reaction time. Plasmonic energy-based ultrafast gene amplification and facile confirmation methodology offer a rapid disease discrimination platform for high-throughput multiplexed diagnosis. The superior performance of the gold nanopillar arrayed film is demonstrated by measuring the amount of pathogen ( Vibrio cholerae ) with a sensitivity of 10 1 cfu mL −1 in 5.5 min. The newly engineered gold nanopillar arrayed film can be utilized to diagnose universal pathogens to achieve an increasingly successful complete cure.}, archive = {J_ADVS}, author = {Sung Eun Seo and Kyung Ho Kim and Seo Jin Kim and Kyong-Cheol Ko and Woo-Keun Kim and Kyoung G. Lee and Oh Seok Kwon}, doi = {10.1002/advs.202411849}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411849}, shortjournal = {Adv. Sci.}, title = {Plasmon-driven gold nanopillar multiarrayed gene amplification methodology for the high-throughput discrimination of pathogens}, volume = {12}, year = {2025}, }
• (2025). Cost-effective DNA storage system with DNA movable type. ADVS, 12(9), 2411354. (www)

  @article{ , abstract = {In the face of exponential data growth, DNA-based storage offers a promising solution for preserving big data. However, most existing DNA storage methods, akin to traditional block printing, require costly chemical synthesis for each individual data file, adopting a sequential, one-time-use synthesis approach. To overcome these limitations, a novel, cost-effective “DNA-movable-type storage” system, inspired by movable type printing, is introduced. This system utilizes prefabricated DNA movable types-short, double-stranded DNA oligonucleotides encoding specific payload, address, and checksum data. These DNA-MTs are enzymatically ligated/assembled into cohesive sequences, termed “DNA movable type blocks,” streamlining the assembly process with the automated BISHENG-1 DNA-MT inkjet printer. Using BISHENG-1, 43.7 KB of data files are successfully printed, assembled, stored, and accurately retrieved in diverse formats (text, image, audio, and video) in vitro and in vivo, using only 350 DNA-MTs. Notably, each DNA-MT, synthesized once (2 OD ), can be used up to 10000 times, reducing costs to $122/MB—outperforming existing DNA storage methods. This innovation circumvents the need to synthesize entire DNA sequences encoding files from scratch, offering significant cost and efficiency advantages. Furthermore, it has considerable untapped potential to advance a robust DNA storage system, better meeting the extensive data storage demands of the big-data era.}, archive = {J_ADVS}, author = {Chenyang Wang and Di Wei and Zheng Wei and Dongxin Yang and Jing Xing and Yunze Wang and Xiaotong Wang and Pei Wang and Guannan Ma and Xinru Zhang and Haolan Li and Chuan Tang and Pengfei Hou and Jie Wang and Renjun Gao and Guiqiu Xie and Cuidan Li and Yingjiao Ju and Peihan Wang and Liya Yue and Yongliang Zhao and Yongjie Sheng and Jingfa Xiao and Haitao Niu and Sihong Xu and Huaiyi Yang and Di Liu and Bo Duan and Dongbo Bu and Guangming Tan and Fei Chen}, doi = {10.1002/advs.202411354}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411354}, shortjournal = {Adv. Sci.}, title = {Cost-effective DNA storage system with DNA movable type}, volume = {12}, year = {2025}, }
• (2025). A fully printable strain sensor enabling highly-sensitive wireless near-field interrogation. ADVS, 12(9), 2411346. (www)

  @article{ , abstract = {Wireless, passive, and flexible strain sensors can transform structural health monitoring across various applications by eliminating the need for wired connections and active power sources. Such sensors offer the dual benefits of operational simplicity and high-function adaptability. Herein, a novel wireless sensor is fabricated using radio frequency (RF) technology for passive, wireless measurement of mechanical strains. Previously introduced concept of coupling piezoresistive electrodes is utilized with capacitive sensors to ensure high-sensitivity capacitive sensing. For the first time, it is implemented and demonstrated here as a fully printable, inexpensive, and ready-to-use device utilizing the recent advances in piezoresistive inks and screen-printing technologies. The near-field communication (NFC) tag features an inductor - capacitor (LC) resonant circuit with a distinct resonant frequency. The sensor exhibits high sensitivity and detects substantial variations in capacitance, with a gauge factor (GF) of ≈16 at 20 MHz for strain levels below 5%. Within the wireless framework, the sensor achieves a significant shift in resonance frequency (GF of ≈2.2). It also exhibited excellent performance in wirelessly monitoring the strain in a glass fiber-reinforced polymer (GFRP) specimen during the bending test. The results confirm the potential applicability of the sensor as an embedded sensor for monitoring various types of composite structures. This confirms the potential of the sensor for use in composite structures as an embedded sensor.}, archive = {J_ADVS}, author = {Hassan A. Mahmoud and Hussein Nesser and Tarek M. Mostafa and Shehab Ahmed and G. Lubineau}, doi = {10.1002/advs.202411346}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411346}, shortjournal = {Adv. Sci.}, title = {A fully printable strain sensor enabling highly-sensitive wireless near-field interrogation}, volume = {12}, year = {2025}, }
• (2025). A multicellular in vitro model of the human intestine with immunocompetent features highlights host-pathogen interactions during early salmonella typhimurium infection. ADVS, 12(9), 2411233. (www)

  @article{ , abstract = {Studying the molecular basis of intestinal infections caused by enteric pathogens at the tissue level is challenging, because most human intestinal infection models have limitations, and results obtained from animals may not reflect the human situation. Infections with Salmonella enterica serovar Typhimurium (STm) have different outcomes between organisms. 3D tissue modeling of primary human material provides alternatives to animal experimentation, but epithelial co-culture with immune cells remains difficult. Macrophages, for instance, contribute to the immunocompetence of native tissue, yet their incorporation into human epithelial tissue models is challenging. A 3D immunocompetent tissue model of the human small intestine based on decellularized submucosa enriched with monocyte-derived macrophages (MDM) is established. The multicellular model recapitulated in vivo-like cellular diversity, especially the induction of GP2 positive microfold (M) cells. Infection studies with STm reveal that the pathogen physically interacts with these M-like cells. MDMs show trans-epithelial migration and phagocytosed STm within the model and the levels of inflammatory cytokines are induced upon STm infection. Infected epithelial cells are shed into the supernatant, potentially reflecting an intracellular reservoir of invasion-primed STm. Together, the 3D model of the human intestinal epithelium bears potential as an alternative to animals to identify human-specific processes underlying enteric bacterial infections.}, archive = {J_ADVS}, author = {Spyridon Damigos and Aylin Caliskan and Gisela Wajant and Sara Giddins and Adriana Moldovan and Sabine Kuhn and Evelyn Putz and Thomas Dandekar and Thomas Rudel and Alexander J. Westermann and Daniela Zdzieblo}, doi = {10.1002/advs.202411233}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411233}, shortjournal = {Adv. Sci.}, title = {A multicellular in vitro model of the human intestine with immunocompetent features highlights host-pathogen interactions during early salmonella typhimurium infection}, volume = {12}, year = {2025}, }
• (2025). Substantial heritability underlies fairness norm adaptation capability and its neural basis. ADVS, 12(9), 2411070. (www)

  @article{ , abstract = {The present research uncovers the shared genetic underpinnings of fairness norm adaptation capability, its neural correlates, and long-term mental health outcomes. One hundred and eighty-six twins are recruited and played as responders in the Ultimatum Game (UG) while undergoing fMRI scanning in their early adulthood (Study-1) and are measured on depressive symptoms eight years later (Study-2). With computational modeling, the process of norm adaptation is differentiated from that of fairness valuation in UG. The two processes both have moderate levels of heritability. The anterior insula has a significant phenotypic correlation, whereas the Supplementary Motor Area/Medial Frontal Gyrus (SMA/mSFG) shows both a significant phenotypic correlation and a shared genetic influence with the learning rate, an index for norm adaptation. The dopaminergic DRD2 polymorphisms correlate with both the learning rate and the SMA/mSFG encoding of prediction error, constituting of their common genetic basis. Regional gene expression analysis reveals the high expression of dopamine-related genes in the SMA/mSFG. Moreover, the learning rate can predict depressive symptom severity eight years later, with the DRD2 polymorphisms constituting their shared genetic basis. This suggests that heritability is a non-negligible driving force behind norm adaptation, which facilitates the learning of social norms in changing environments and preserves long-term mental health.}, archive = {J_ADVS}, author = {Yuening Jin and Dang Zheng and Ruolei Gu and Qingchen Fan and Martin Dietz and Changshuo Wang and Xinying Li and Jie Chen and Yuanyuan Hu and Yuan Zhou}, doi = {10.1002/advs.202411070}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411070}, shortjournal = {Adv. Sci.}, title = {Substantial heritability underlies fairness norm adaptation capability and its neural basis}, volume = {12}, year = {2025}, }
• (2025). Artificial intelligence-based approaches for AAV vector engineering. ADVS, 12(9), 2411062. (www)

  @article{ , abstract = {Adeno-associated virus (AAV) has emerged as a leading vector for gene therapy due to its broad host range, low pathogenicity, and ability to facilitate long-term gene expression. However, AAV vectors face limitations, including immunogenicity and insufficient targeting specificity. To enhance the efficacy of gene therapy, researchers have been modifying the AAV vector using various methods. Traditional experimental approaches for optimizing AAV vector are often time-consuming, resource-intensive, and difficult to replicate. The advancement of artificial intelligence (AI), particularly machine learning, offers significant potential to accelerate capsid optimization while reducing development time and manufacturing costs. This review compares traditional and AI-based methods of AAV vector engineering and highlights recent research in AAV engineering using AI algorithms.}, archive = {J_ADVS}, author = {Fangzhi Tan and Yue Dong and Jieyu Qi and Wenwu Yu and Renjie Chai}, doi = {10.1002/advs.202411062}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2411062}, shortjournal = {Adv. Sci.}, title = {Artificial intelligence-based approaches for AAV vector engineering}, volume = {12}, year = {2025}, }
• (2025). Haplotype-resolved genotyping and association analysis of 1,020 β-thalassemia patients by targeted long-read sequencing. ADVS, 12(9), 2410992. (www)

  @article{ , abstract = {Despite the well-documented mutation spectra of β-thalassemia, the genetic variants and haplotypes of globin gene clusters modulating its clinical heterogeneity remain incompletely illustrated. Here, a targeted long-read sequencing (T-LRS) is demonstrated to capture 20 genes/loci in 1,020 β-thalassemia patients. This panel permits not only identification of thalassemia mutations at 100% of sensitivity and specificity, but also detection of rare structural variants (SVs) and single nucleotide variants (SNVs) in modifier genes/loci. The highly homologous regions of α-/β-globin gene clusters are then phased and 3 novel haplotypes in HBG1/HBG2 region are reported in this population of β-thalassemia patients. Furthermore, one of the haplotypes is associated with ameliorated symptoms of β-thalassemia. Similarly, 5 major haplotypes are identified in HBA1/HBA2 homologous region while one of them is found highly linked with deletional α-thalassemia mutations. Finally, rare mutations in erythroid transcription factors in DNMT1 and KLF1 associated with increased expression of fetal hemoglobin and reduced transfusion dependencies are identified. This study presents the largest T-LRS study for β-thalassemia patients to date, facilitating precise clinical diagnosis and haplotype phasing of globin gene clusters.}, archive = {J_ADVS}, author = {Yuhua Ye and Chao Niu and Aiping Mao and Lang Qin and Jiahan Zhan and Weijie Chen and Zhentian Liu and Tiantian Xie and Qianqian Zhang and Jiaqi Li and Li Huang and Wanli Meng and Yumeng Liu and Liuhua Liao and Junqin Cai and Riyang Liu and Xinhua Zhang and Lihong Zeng and Yaoyun Li and Bin Lin and Kui Li and Xiaoyun Hua and Binbin Huang and Honggui Qin and Yueyan Huang and Zhijing Huang and Jinquan Lao and Xiang Qu and Juanjuan Chen and Xiaoqin Feng and Qiujun Liu and Wanying Lin and Xiaoman Zhou and Yidan Liang and Xingjiang Long and Jiaofeng Qin and Lixiang Yan and Weijian Zhu and Lian Yu and Chengwu Fan and Deguo Tang and Tianyu Zhong and Jufang Tan and Zhilin Ren and Xiangmin Xu}, doi = {10.1002/advs.202410992}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410992}, shortjournal = {Adv. Sci.}, title = {Haplotype-resolved genotyping and association analysis of 1,020 β-thalassemia patients by targeted long-read sequencing}, volume = {12}, year = {2025}, }
• (2025). MMFuncPhos: A multi-modal learning framework for identifying functional phosphorylation sites and their regulatory types. ADVS, 12(9), 2410981. (www)

  @article{ , abstract = {Protein phosphorylation plays a crucial role in regulating a wide range of biological processes, and its dysregulation is strongly linked to various diseases. While many phosphorylation sites have been identified so far, their functionality and regulatory effects are largely unknown. Here, a deep learning model MMFuncPhos, based on a multi-modal deep learning framework, is developed to predict functional phosphorylation sites. MMFuncPhos outperforms existing functional phosphorylation site prediction approaches. EFuncType is further developed based on transfer learning to predict whether phosphorylation of a residue upregulates or downregulates enzyme activity for the first time. The functional phosphorylation sites predicted by MMFuncPhos and the regulatory types predicted by EFuncType align with experimental findings from several newly reported protein phosphorylation studies. The study contributes to the understanding of the functional regulatory mechanism of phosphorylation and provides valuable tools for precision medicine, enzyme engineering, and drug discovery. For user convenience, these two prediction models are integrated into a web server which can be accessed at http://pkumdl.cn:8000/mmfuncphos .}, archive = {J_ADVS}, author = {Juan Xie and Ruihan Dong and Jintao Zhu and Haoyu Lin and Shiwei Wang and Luhua Lai}, doi = {10.1002/advs.202410981}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410981}, shortjournal = {Adv. Sci.}, title = {MMFuncPhos: A multi-modal learning framework for identifying functional phosphorylation sites and their regulatory types}, volume = {12}, year = {2025}, }
• (2025). Traditional chinese medicine borneol-based polymeric micelles intracerebral drug delivery system for precisely pathogenesis-adaptive treatment of ischemic stroke. ADVS, 12(9), 2410889. (www)

  @article{ , abstract = {The scarcity of effective neuroprotective agents and the presence of blood-brain barrier (BBB)-mediated extremely inefficient intracerebral drug delivery are predominant obstacles to the treatment of cerebral ischemic stroke (CIS). Herein, ROS-responsive borneol-based amphiphilic polymeric NPs are constructed by using traditional Chinese medicine borneol as functional blocks that served as surface brain-targeting ligand, inner hydrophobic core for efficient drug loading of membrane-permeable calcium chelator BAPTA-AM, and neuroprotective structural component. In MCAO mice, the nanoformulation (polymer: 3.2 mg·kg −1 , BAPTA-AM: 400 µg·kg −1 ) reversibly opened the BBB and achieved high brain biodistribution up to 12.7%ID/g of the total administered dose after 3 h post single injection, effectively restoring intracellular Ca 2+ and redox homeostasis, improving cerebral histopathology, and inhibiting mitochondrial PI3K/Akt/Bcl-2/Bax/Cyto-C/Caspase-3,9 apoptosis pathway for rescuing dying neurons (reduced apoptosis cell from 59.5% to 7.9%). It also remodeled the inflammatory microenvironment in cerebral ischemic penumbra by inhibiting astrocyte over-activation, reprogramming microglia polarization toward an anti-inflammatory phenotype, and blocking NF-κB/TNF- α /IL-6 signaling pathways. These interventions eventually reduced the cerebral infarction area by 96.3%, significantly improved neurological function, and restored blood flow reperfusion from 66.2% to ≈100%, all while facilitating BBB repair and avoiding brain edema. This provides a potentially effective multiple-stage sequential treatment strategy for clinical CIS.}, archive = {J_ADVS}, author = {Yanan Wang and Xutao Ma and Xinyuan Wang and Liru Liu and Xue Zhang and Qiuyue Wang and Yingfei Zhu and Huanhua Xu and Liangmin Yu and Zhiyu He}, doi = {10.1002/advs.202410889}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410889}, shortjournal = {Adv. Sci.}, title = {Traditional chinese medicine borneol-based polymeric micelles intracerebral drug delivery system for precisely pathogenesis-adaptive treatment of ischemic stroke}, volume = {12}, year = {2025}, }
• (2025). Multi-miRNAs-mediated hepatic lepr axis suppression: A Pparg–Dicer1 pathway-driven mechanism in spermatogenesis for the intergenerational transmission of paternal metabolic syndrome. ADVS, 12(9), 2410831. (www)

  @article{ , abstract = {Bisphenol A (BPA) is an “environmental obesogen” and this study aims to investigate the intergenerational impacts of BPA-induced metabolic syndrome (MetS), specifically focusing on unraveling mechanisms. Exposure to BPA induces metabolic disorders in the paternal mice, which are then transmitted to offspring, leading to late-onset MetS. Mechanistically, BPA upregulates Srebf1, which in turn promotes the Pparg-dependent transcription of Dicer1 in spermatocytes, increasing the levels of multiple sperm microRNAs (miRNAs). Several of these miRNAs are highly expressed in a synchronized manner in liver of the offspring. miR149-5p, miR150-5p, and miR700-5p target a specific region in the Lepr 3′UTR, termed “SMITE” (“ S everal Mi RNAs T argeting E lements”), to negatively regulate Lepr. These i nherited a nti- L epr miRNAs, also referred to i nherited a nti- L epr miRNAs (IAL-miRs), modulate hepatic steatosis, and insulin signaling through the Lepr regulatory Igfbp2, Egfr, and Ampk. Furthermore, IAL-miRs inhibit Ccnd1 not only via binding to “SMITE” but also via Lepr–Igfbp2 axis, which contribute to hepatocyte senescence. These pathological processes interact in a self-reinforcing cycle, worsening MetS in the paternal BPA-exposed offspring. The findings reveal mechanism wherein lipid metabolism reprogramming in spermatocytes-induced perturbations of sperm miRNAs, triggered by BPA, leads to intergenerational inheritance of paternal MetS through suppression of the hepatic Lepr axis in the offspring.}, archive = {J_ADVS}, author = {Yi Lin and Xiuye Ni and Lin Zhu and Yilong Lin and Cai Peng and Zhao Lei and Yihui Wang and Huan Wang and Xiang You and Juan Li and Heqing Shen and Jie Wei}, doi = {10.1002/advs.202410831}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410831}, shortjournal = {Adv. Sci.}, title = {Multi-miRNAs-mediated hepatic lepr axis suppression: A Pparg–Dicer1 pathway-driven mechanism in spermatogenesis for the intergenerational transmission of paternal metabolic syndrome}, volume = {12}, year = {2025}, }
• (2025). “Three-in-one” analysis of proteinuria for disease diagnosis through multifunctional nanoparticles and machine learning. ADVS, 12(9), 2410751. (www)

  @article{ , abstract = {Urinalysis is one of the predominant tools for clinical testing owing to the abundant composition, sufficient volume, and non-invasive acquisition of urine. As a critical component of routine urinalysis, urine protein testing measures the levels and types of proteins, enabling the early diagnosis of diseases. Traditional methods require three separate steps including strip testing, protein/creatinine ratio measurement, and electrophoresis respectively to achieve qualitative, quantitative, and classification analyses of proteins in urine with long time and cumbersome operations. Herein, this work demonstrates a “three-in-one” protocol to analyze the urine composition by combining multifunctional nanoparticles with machine learning. This work constructs a sensor array to analyze proteinuria by employing nanoparticles with unique optical properties, outstanding catalytic activity, diverse composition, and tunable structure as probes. Different proteins interacted with nanoprobes differently and are classified by this sensor array based on their physicochemical heterogeneities. With the aid of machine learning, the urine composition is precisely detected for the diagnosis of bladder cancer. This protocol enables quantification and classification of 5 proteinuria in 10 min without any tedious pretreatment, showing proimise for the comprehensive analysis of body fluid for early disease diagnosis.}, archive = {J_ADVS}, author = {Yidan Wang and Jiazhu Sun and Jiuhong Yi and Ruijie Fu and Ben Liu and Yunlei Xianyu}, doi = {10.1002/advs.202410751}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410751}, shortjournal = {Adv. Sci.}, title = {“Three-in-one” analysis of proteinuria for disease diagnosis through multifunctional nanoparticles and machine learning}, volume = {12}, year = {2025}, }
• (2025). Pheno-morphological screening and acoustic sorting of 3D multicellular aggregates using drop millifluidics. ADVS, 12(9), 2410677. (www)

  @article{ , abstract = {Three-dimensional multicellular aggregates (MCAs) like organoids and spheroids have become essential tools to study the biological mechanisms involved in the progression of diseases. In cancer research, they are now widely used as in vitro models for drug testing. However, their analysis still relies on tedious manual procedures, which hinders their routine use in large-scale biological assays. Here, a novel drop millifluidic approach is introduced to screen and sort large populations containing over one thousand MCAs: ImOCAS (Image-based Organoid Cytometry and Acoustic Sorting). This system utilizes real-time image processing to detect pheno-morphological traits in MCAs. They are then encapsulated in millimetric drops, actuated on-demand using the acoustic radiation force. The performance of ImOCAS is demonstrated by sorting spheroids with uniform sizes from a heterogeneous population, and by isolating organoids from spheroids with different phenotypes. This approach lays the groundwork for high-throughput screening and high-content analysis of MCAs with controlled morphological and phenotypical properties, which promises accelerated progress in biomedical research.}, archive = {J_ADVS}, author = {Leon Rembotte and Thomas Beneyton and Lionel Buisson and Amaury Badon and Adeline Boyreau and Camille Douillet and Loic Hermant and Anirban Jana and Pierre Nassoy and Jean-Christophe Baret}, doi = {10.1002/advs.202410677}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410677}, shortjournal = {Adv. Sci.}, title = {Pheno-morphological screening and acoustic sorting of 3D multicellular aggregates using drop millifluidics}, volume = {12}, year = {2025}, }
• (2025). Enhancing the implant osteointegration via supramolecular co-assembly coating with early immunomodulation and cell colonization. ADVS, 12(9), 2410595. (www)

  @article{ , abstract = {Osteointegration, the effective coupling between an implant and bone tissue, is a highly intricate biological process. The initial stages of bone-related immunomodulation and cellular colonization play crucial roles, but have received limited attention. Herein, a novel supramolecular co-assembled coating of strontium (Sr)-doped metal polyphenol networks (MPN) modified with c(RGDfc) is developed and well-characterized, for eliciting an early immunomodulation and cellular colonization. The results showed that the (Sr-MPN)@RGD coating significantly regulated the polarization of macrophages to the M2 phenotype by controllable release of Sr, and promote the initial adhesion of bone marrow mesenchymal stem cells (BMSCs) by RGD presented on MPN. Notably, the (Sr-MPN)@RGD attenuated osteoclast differentiation and oxidative stress as well as enhanced osteoblast differentiation and angiogenesis due to macrophage polarization toward M2 phenotype, which in turn has a profound effect on neighboring cells through paracrine signaling. In vivo results showed that the (Sr-MPN)@RGD coating manifested superior osseointegration and bone maturation to the bare Ti-rod or Ti-rod coated with MPN and Sr-MPN. This work contributed to the design of multifunctional implant coatings that address the complex biological process of osteointegration from the perspective of orchestrating stem cell recruitment with immunomodulatory strategies.}, archive = {J_ADVS}, author = {Chenglong Wang and Zeyu Shou and Chengwei Xu and Kaiyuan Huo and Wenjie Liu and Hao Liu and Xingjie Zan and Qing Wang and Lianxin Li}, doi = {10.1002/advs.202410595}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410595}, shortjournal = {Adv. Sci.}, title = {Enhancing the implant osteointegration via supramolecular co-assembly coating with early immunomodulation and cell colonization}, volume = {12}, year = {2025}, }
• (2025). Mitochondrial electron flow dynamics imaging for assessing mitochondrial quality and drug screening. ADVS, 12(9), 2410561. (www)

  @article{ , abstract = {Mitochondrial quality control is paramount for cellular development, with mitochondrial electron flow (Mito-EF) playing a central role in maintaining mitochondrial homeostasis. However, unlike visible protein entities, which can be monitored through chemical biotechnology, regulating mitochondrial quality control by invisible entities such as Mito-EF has remained elusive. Here, a Mito-EF tracker (Mito-EFT) with a four-pronged probe design is presented to elucidate the dynamic mechanisms of Mito-EF's involvement in mitochondrial quality control. Heightened aggregation of Mito-EF in fiber-like healthy mitochondria compared to round-like damaged mitochondria is demonstrated, revealed Mito-EF aggregation correlated with mitochondrial morphological remodeling, particularly in regions undergoing mitochondrial fission and fusion, and show the Mito-EF signal associated with mitochondrial cristae maintained by Dynamin-Related Protein 1 (DRP1). This underscores the importance of considering Mito-EF in assessing mitochondrial quality control parameters. A novel drug screening evaluation parameter, Mito-EF is also introduced to screen and discover mitochondrial-targeted therapeutic modulators. This tracker provides new avenues for investigating the role of Mito-EF in maintaining mitochondrial homeostasis and quality control, offering a potent tool for assessing mitochondrial quality and drug screening.}, archive = {J_ADVS}, author = {Youxiao Ren and Ling-Ling Wu and Wenjing Song and Yanan Gao and Litao Shao and Zhiyuan Lu and Songsong Wang and Xintian Shao and Zhenjie Yu and Mengrui Zhang and Jing Wu and Liwen Han and Kewu Zeng and Qixin Chen}, doi = {10.1002/advs.202410561}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410561}, shortjournal = {Adv. Sci.}, title = {Mitochondrial electron flow dynamics imaging for assessing mitochondrial quality and drug screening}, volume = {12}, year = {2025}, }
• (2025). In-plane anisotropy in van der waals NiTeSe ternary alloy. ADVS, 12(9), 2410549. (www)

  @article{ , abstract = {The anisotropic properties of materials profoundly influence their electronic, magnetic, optical, and mechanical behaviors and are critical for a wide range of applications. In this study, the anisotropic characteristics of Ni-based van der Waals materials, specifically NiTe 2 and its alloy NiTeSe, utilizing a combination of comprehensive scanning tunneling microscopy (STM), angle-resolved photoemission spectroscopy (ARPES), and density functional theory (DFT) calculations, are explored. Unlike 1T-NiTe 2 , which exhibits trigonal in-plane symmetry, the substitution of Te with Se in NiTe 2 (resulting in the NiTeSe alloy) induces a pronounced in-plane anisotropy. This anisotropy is clear in the STM topographs, which reveal a distinct linear order of charge distribution. Corroborating these observations, ARPES measurements and DFT calculations reveal an anisotropic Fermi surface centered at the point, which is notably elongated along the k y direction, leading to directional variations in in-plane carrier velocities. Consequently, the Fermi velocity is highest along the k x direction where the linear charge distribution aligns in real space and is lowest along the k y direction. These findings offer valuable insights into the tunability of anisotropic properties in ternary transition metal dichalcogenide systems, highlighting their potential applications in the development of anisotropic electronic and optoelectronic devices.}, archive = {J_ADVS}, author = {Nguyen Huu Lam and Tae Gyu Rhee and Seongmun Kim and Byoung Ki Choi and Dang Nguyen Hoang and Ganbat Duvjir and Younghun Hwang and Jaekwang Lee and Young Jun Chang and Jungdae Kim}, doi = {10.1002/advs.202410549}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410549}, shortjournal = {Adv. Sci.}, title = {In-plane anisotropy in van der waals NiTeSe ternary alloy}, volume = {12}, year = {2025}, }
• (2025). Achieving narrowband and stable pure blue organic light-emitting diodes by employing molecular vibration limited strategies in the extended π-conjugated indolocarbazole skeleton. ADVS, 12(9), 2410479. (www)

  @article{ , abstract = {B- and N-heterocyclic fluorophores have reveal promising efficiency in blue organic light-emitting diodes (OLEDs) with small full-width-at-half-maximum (FWHM). However, their structural determinants for spectral broadening and operating stability are still needed to be investigated in further. Herein, a novel multi-N-heterocycles Diindolo[3,2,1jk:3′,2′,1′jk]dicarbazole[1,2-b:4,5-b] (DIDCz) is proposed to manipulate the emission color toward pure blue region by extending π-conjugation of the N-π-N bridge. By utilizing computed spectral technique, interrelationships between indolocarbazole (ICz)-cyclization sites and spectral broadening are defined. Molecular backbone modifications involving optimized 2,3,6,7-ICz cyclization and steric hindrance substituents are conducive to restricting swing of peripheral bonds and stretching resonances of the polycyclic aromatic hydrocarbon (PAH) frameworks, thereby contributing to the reduction of shoulder emission peaks. Consequently, the DIDCz-based chromophore exhibited narrowband blue emission with a FWHM of only 15 nm, achieving highly efficient (external quantum efficiencies of 8.87% in triplet–triplet fusion fluorescence and 22.3% in sensitized fluorescence) and long-term (95% of the initial luminance of 1000 cd m −2 , T95 = 1545 h) electroluminescence performances, showing one of the most narrowband and stable blue OLEDs among the reported PAH chromophores. The current achievements offer a new perspective to manage spectral broadening precisely based on the molecular vibration limiting technique.}, archive = {J_ADVS}, author = {Zhiheng Wang and Xuming Hu and Zhiping Yan and Jie Liang and Xiaoxian Song and Qishen Chen and Hai Bi and Yue Wang}, doi = {10.1002/advs.202410479}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410479}, shortjournal = {Adv. Sci.}, title = {Achieving narrowband and stable pure blue organic light-emitting diodes by employing molecular vibration limited strategies in the extended π-conjugated indolocarbazole skeleton}, volume = {12}, year = {2025}, }
• (2025). Liver-secreted extracellular vesicles promote cirrhosis-associated skeletal muscle injury through mtDNA-cGAS/STING axis. ADVS, 12(9), 2410439. (www)

  @article{ , abstract = {Skeletal muscle atrophy (sarcopenia) is a serious complication of liver cirrhosis, and chronic muscle inflammation plays a pivotal role in its pathologenesis. However, the detailed mechanism through which injured liver tissues mediate skeletal muscle inflammatory injury remains elusive. Here, it is reported that injured hepatocytes might secrete mtDNA-enriched extracellular vesicles (EVs) to trigger skeletal muscle inflammation by activating the cGAS-STING pathway. Briefly, injured liver secreted increased amounts of EVs into circulation, which are then engulfed primarily by macrophages in skeletal muscle and subsequently induce cGAS-STING signaling and its-mediated inflammatory response in muscles. In contrast, suppression of hepatic EV secretion or STING signaling significantly alleviated cirrhosis-induced skeletal muscle inflammation and muscle atrophy in vivo. Circulating EVs from cirrhotic patients showed higher levels of mtDNA, and the levels of EV-mtDNA positively correlated with the severity of liver injury. In injured hepatocytes, mitochondrial damage promoted the release of cytosolic mtDNA and the subsequent secretion of mtDNA-enriched EVs. This study reveals that injured hepatocyte-derived EVs induce skeletal muscle inflammation via the mtDNA‒STING axis, while targeted blockade of liver EV secretion or STING signaling represents a potential therapeutic approach for preventing cirrhosis-associated skeletal muscle atrophy.}, archive = {J_ADVS}, author = {Xiaoli Fan and Yunke Peng and Bo Li and Xiaoze Wang and Yifeng Liu and Yi Shen and Guofeng Liu and Yanyi Zheng and Qiaoyu Deng and Jingping Liu and Li Yang}, doi = {10.1002/advs.202410439}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410439}, shortjournal = {Adv. Sci.}, title = {Liver-secreted extracellular vesicles promote cirrhosis-associated skeletal muscle injury through mtDNA-cGAS/STING axis}, volume = {12}, year = {2025}, }
• (2025). Co-atomic interface minimizing charge transfer barrier in polytypic perovskites for CO2 photoreduction. ADVS, 12(9), 2410437. (www)

  @article{ , abstract = {Heterojunctions, known for their decent separation of photo-generated electrons and holes, are promising for photocatalytic CO 2 reduction. However, a significant obstacle in traditional post-assembled heterojunctions is the high interfacial barrier for charge transfer caused by atomic lattice mismatch at multiphase interfaces. Here, as research prototypes, the study creates a lattice-matched co-atomic interface within CsPbBr 3 -CsPb 2 Br 5 polytypic nanocrystals (113-125 PNs) through the proposed in situ hybrid strategy to elucidate the underlying charge transfer mechanism within this unique interface. Compared to CsPbBr 3 nanocrystals, the 113–125 PNs exhibit a remarkable 3.6-fold increase in photocatalytic CO 2 reduction activity (173.3 µmol −1 g −1 within 5 h). Furthermore, Kelvin probe force microscopy results reveal an increase in the built-in electric field within this lattice-matched co-atomic interface from 43.5 to 68.7 mV, providing a stronger driving force for charge separation and directional migration. Additionally, ultrafast transient absorption spectroscopy uncovers the additional charge carrier transfer pathways across this lattice-matched co-atomic interface. Thus, this unique co-atomic interface significantly promotes the interfacial electronic coupling and mitigates the charge transfer barrier, thus facilitating efficient charge separation and transfer. These insights underscore the importance of interfacial structure in heterojunction design and comprehending the intricate interplay between interface and carrier dynamics.}, archive = {J_ADVS}, author = {Fengyi Zhong and Jianping Sheng and Chenyu Du and Ye He and Fengying Zhang and Yanjuan Sun and Ying Zhou and Fan Dong}, doi = {10.1002/advs.202410437}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410437}, shortjournal = {Adv. Sci.}, title = {Co-atomic interface minimizing charge transfer barrier in polytypic perovskites for CO2 photoreduction}, volume = {12}, year = {2025}, }
• (2025). An albumin-photosensitizer supramolecular assembly with type i ROS-induced multifaceted tumor cell deaths for photodynamic immunotherapy. ADVS, 12(9), 2410405. (www)

  @article{ , abstract = {Photodynamic therapy holds great potentials in cancer treatment, yet its effectiveness in hypoxic solid tumor is limited by the oxygen-dependence and insufficient oxidative potential of conventional type II reactive oxygen species (ROS). Herein, the study reports a supramolecular photosensitizer, BSA@TPE-BT-SCT NPs, through encapsulating aggregation-enhanced emission photosensitizer by bovine serum albumin (BSA) to significantly enhance ROS, particularly less oxygen-dependent type I ROS for photodynamic immunotherapy. The abundant type I ROS generated by BSA@TPE-BT-SCT NPs induce multiple forms of programmed cell death, including apoptosis, pyroptosis, and ferroptosis. These multifaceted cell deaths synergistically facilitate the release of damage-associated molecular patterns and antitumor cytokines, thereby provoking robust antitumor immunity. Both in vitro and in vivo experiments confirmed that BSA@TPE-BT-SCT NPs elicited the immunogenic cell death, enhance dendritic cell maturation, activate T cell, and reduce myeloid-derived suppressor cells, leading to the inhibition of both primary and distant tumors. Additionally, BSA@TPE-BT-SCP NPs also exhibited excellent antitumor performance in a humanized mice model, evidenced by a reduction in senescent T cells among these activated T cells. The findings advance the development of robust type I photosensitizers and unveil the important role of type I ROS in enhancing multifaceted tumor cell deaths and antitumor immunogenicity.}, archive = {J_ADVS}, author = {Jingtian Zhang and Di Jiao and Xinwen Qi and Yufan Zhang and Xiaoang Liu and Tengwu Pan and Heqi Gao and Zhaoyun Liu and Dan Ding and Guangxue Feng}, doi = {10.1002/advs.202410405}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410405}, shortjournal = {Adv. Sci.}, title = {An albumin-photosensitizer supramolecular assembly with type i ROS-induced multifaceted tumor cell deaths for photodynamic immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Toward large-scale photonic chips using low-anisotropy thin-film lithium-tantalate. ADVS, 12(9), 2410345. (www)

  @article{ , abstract = {Photonic manipulation of large-capacity data with the advantages of high speed and low power consumption is a promising solution for explosive growth demands in the era of post-Moore. A well-developed lithium-niobate-on-insulator (LNOI) platform has been widely explored for high-performance electro-optic (EO) modulators to bridge electrical and optical signals. However, the photonic waveguides on the x-cut LNOI platform suffer serious polarization-mode conversion/coupling issues because of strong birefringence, making it hard to realize large-scale integration. Here, low-birefringence photonic integrated circuits (PICs) based on lithium-tantalate-on-insulator (LTOI) are proposed and demonstrated, which enables high-performance passive photonic devices as well as EO modulators, showing great potential for large-scale photonic chips. Analysis of mode conversion and evolution behaviors with both low- and high-birefringence shows undesired mode hybridizations can be effectively suppressed. A simple and universal fabrication process is developed and various representative passive photonic devices are demonstrated with impressive performances. Finally, a wavelength-division-multiplexed optical transmitter is developed with a data rate of 1.6 Tbps by monolithically integrating 8 EO modulators and an 8-channel arrayed waveguide grating. Therefore, the demonstrated low-birefringence LTOI platform shows strong ability in both passively and actively controlling photon behaviors on a chip, indicating great potential for ultrafast processing and communicating large-capacity data.}, archive = {J_ADVS}, author = {Fei Huang and Xiaowan Shen and Siyuan Wang and Haochen Xu and Hongxuan Liu and Zexu Wang and He Gao and Xinmin Yao and Hengzhen Cao and Bin Chen and Xijie Wang and Jizhi Zhang and Zhile Wu and Mingyu Zhu and Hongzhi Xiong and Weike Zhao and Huan Li and Zejie Yu and Liu Liu and Yaocheng Shi and Daoxin Dai}, doi = {10.1002/advs.202410345}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410345}, shortjournal = {Adv. Sci.}, title = {Toward large-scale photonic chips using low-anisotropy thin-film lithium-tantalate}, volume = {12}, year = {2025}, }
• (2025). Molecular determinants of protein pathogenicity at the single-aggregate level. ADVS, 12(9), 2410229. (www)

  @article{ , abstract = {Determining the structure-function relationships of protein aggregates is a fundamental challenge in biology. These aggregates, whether formed in vitro, within cells, or in living organisms, present significant heterogeneity in their molecular features such as size, structure, and composition, making it difficult to determine how their structure influences their functions. Interpreting how these molecular features translate into functional roles is crucial for understanding cellular homeostasis and the pathogenesis of various debilitating diseases like Alzheimer's and Parkinson's. In this study, a bottom-up approach is introduced to explore how variations in protein aggregates’ size, composition, post-translational modifications and point mutations profoundly influence their biological functions. Applying this method to Alzheimer's and Parkinson's associated proteins, novel disease-relevant pathways are uncovered, demonstrating how subtle alterations in composition and morphology can shift the balance between healthy and pathological states. This findings provide deeper insights into the molecular basis of protein's functions at the single-aggregate level, enhancing the knowledge of their roles in health and disease.}, archive = {J_ADVS}, author = {Agnieszka Urbanek and Emma F. Garland and Emily E. Prescott and Marianne C. King and Anna Olerinyova and Hollie E. Wareing and Nia Georgieva and Ellie L. Bradshaw and Svetomir B. Tzokov and Alexander Knight and Alexander I. Tartakovskii and Tarja Malm and J Robin Highley and Suman De}, doi = {10.1002/advs.202410229}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2410229}, shortjournal = {Adv. Sci.}, title = {Molecular determinants of protein pathogenicity at the single-aggregate level}, volume = {12}, year = {2025}, }
• (2025). Bacteroides fragilis transplantation reverses reproductive senescence by transporting extracellular vesicles through the gut-ovary axis. ADVS, 12(9), 2409740. (www)

  @article{ , abstract = {The diverse and dynamic population of microorganisms present in the gut microbiota may affect host health. There are evidences to support the role of gut microbiota as a key player in reproductive development. Unfortunately, the relationship between reproductive disorders caused by aging and gut microbiota remains largely unknown. Here, it is shown for the first time that gut microorganism Bacteroides fragilis (BF) transplantation ameliorates ovarian aging by transporting extracellular vesicles (EVs) through the gut-ovary axis. Mechanistically, miR-1246 is enriched in EVs derived from BF-treated intestinal cells, and these miR-1246-enriched EVs are transferred to ovaries, thereby effectively improving reproductive senescence by reducing oxidative stress in the ovaries. Specifically, miR-1246 reduces the ubiquitination of p62 and stabilizes the protein level of p62 by targeting E3 ligase SKP2. Then Keap1-Nrf2 complex is dissociated and Keap1 is recruited to form the p62-Keap1 complex. With the dissociation of Keap1-Nrf2 complex, Nrf2 is released and activated, thus promoting the transcription of antioxidant enzymes and relieving reproductive senescence. Collectively, the data indicates that intestinal cell-derived EVs serve as natural information carriers in the crosstalk between the gut and the ovary, and intestinal microorganism transplantation is a promising approach for the treatment of ovarian dysfunction diseases.}, archive = {J_ADVS}, author = {Yan Xiong and Xiaoxue Lu and Bohao Li and Shiyao Xu and Beibei Fu and Zhou Sha and Rong Tian and Rui Yao and Qian Li and Jingmin Yan and Dong Guo and Zixuan Cong and Yongliang Du and Xiaoyuan Lin and Haibo Wu}, doi = {10.1002/advs.202409740}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2409740}, shortjournal = {Adv. Sci.}, title = {Bacteroides fragilis transplantation reverses reproductive senescence by transporting extracellular vesicles through the gut-ovary axis}, volume = {12}, year = {2025}, }
• (2025). Exceptional uptake, limited protein expression: Liver macrophages lost in translation of synthetic mRNA. ADVS, 12(9), 2409729. (www)

  @article{ , abstract = {Most gene therapies exert their actions via manipulation of hepatocytes (parenchymal cells) and the reasons behind the suboptimal performance of synthetic mRNA in non-parenchymal cells (NPC) such as Kupffer cells (KC), and liver macrophages, remain unclear. Here, the spatio-temporal distribution of mRNA encoding enhanced green fluorescent protein ( Egfp ), siRNA, or both co-encapsulated into lipid nanoparticles (LNP) in the liver in vivo using real-time intravital imaging is investigated. Although both KC and hepatocytes demonstrate comparable high and rapid uptake of mRNA-LNP and siRNA-LNP in vivo, the translation of Egfp mRNA occurs exclusively in hepatocytes during intravital imaging. Despite attempts such as inhibiting intracellular ribonuclease, substituting uridine bases in mRNA with pseudouridine, and using a different ionizable lipid in the LNP mixture, no substantial increase in Egfp translation by NPC is possible. The investigation reveals that hepatocytes, which are distinct from other liver cells due to their polyploidy, exhibit significantly elevated levels of total RNA and protein, along with a higher proportion of ribosomal protein per individual cell. Consequently, fundamental cellular differences account for the low mRNA translation observed in NPC. The findings therefore suggest that cellular biology imposes a natural limitation on synthetic mRNA translation that is strongly influenced by cellular ploidy.}, archive = {J_ADVS}, author = {Cheng Lin and Adrian Kuzmanović and Nan Wang and Liangliang Liao and Sabrina Ernst and Christian Penners and Alexander Jans and Thomas Hammoor and Petra Bumnuri Stach and Mona Peltzer and Ines Volkert and Elisabeth Zechendorf and Reham Hassan and Maiju Myllys and Christian Liedtke and Andreas Herrmann and Gurudas Chakraborty and Christian Trautwein and Jan Hengstler and Gerhard Müller-Newen and Junqing Wang and Ahmed Ghallab and Matthias Bartneck}, doi = {10.1002/advs.202409729}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2409729}, shortjournal = {Adv. Sci.}, title = {Exceptional uptake, limited protein expression: Liver macrophages lost in translation of synthetic mRNA}, volume = {12}, year = {2025}, }
• (2025). Modulation of RuO2 nanocrystals with facile annealing method for enhancing the electrocatalytic activity on overall water splitting in acid solution. ADVS, 12(9), 2409249. (www)

  @article{ , abstract = {RuO 2 -based materials are considered an important kind of electrocatalysts on oxygen evolution reaction and water electrolysis, but the reported discrepancies of activities exist among RuO 2 electrocatalysts prepared via different processes. Herein, a highly efficient RuO 2 catalysts via a facile hydrolysis-annealing approach is reported for water electrolysis. The RuO 2 catalyst dealt with at 200 °C (RuO 2 -200) performs the highest activities on both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in acid with overpotentials of 200 mV for OER and 66 mV for HER to reach a current density of 100 mA cm −2 as well as stable operation for100 h. The high-resolution transmission electron microscopy (HRTEM) and X-ray photoelectron spectroscopy (XPS) characterizations show that the activities of as-prepared RuO 2 rely on the hydroxide group/lattice oxygen (OH − /O 2− ) ratio, size, and crystalline of RuO 2 . The density functional theory (DFT) calculation also reveal that the OH − would enhance the activities of RuO 2 for HER and OER via modifying the electronic structure to facilitate intermediate adsorption, thereby reducing the energy barrier of the rate-determining step. The water electrolysis by using RuO 2 -200 as the catalyst on both anode and cathode demonstrates a stable generation of hydrogen and oxygen with high Faradic efficiency at a current density of ≈30 mA cm −2 and a potential of below 1.47 V.}, archive = {J_ADVS}, author = {Kangjin Song and Feng Bao and Zheling Wang and Shengding Chang and Na Yao and Haiqing Ma and Yadong Li and Caizhen Zhu and Hong Xia and Fushen Lu and Yibing Song and Jin Wang and Muwei Ji}, doi = {10.1002/advs.202409249}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2409249}, shortjournal = {Adv. Sci.}, title = {Modulation of RuO2 nanocrystals with facile annealing method for enhancing the electrocatalytic activity on overall water splitting in acid solution}, volume = {12}, year = {2025}, }
• (2025). Mannose promotes β-amyloid pathology by regulating BACE1 glycosylation in alzheimer's disease. ADVS, 12(9), 2409105. (www)

  @article{ , abstract = {Hyperglycemia accelerates Alzheimer's disease (AD) progression, yet the role of monosaccharides remains unclear. Here, it is demonstrated that mannose, a hexose, closely correlates with the pathological characteristics of AD, as confirmed by measuring mannose levels in the brains and serum of AD mice, as well as in the serum of AD patients. AD mice are given mannose by intra-cerebroventricular injection (ICV) or in drinking water to investigate the effects of mannose on cognition and AD pathological progression. Chronic mannose overload increases β-amyloid (Aβ) burdens and exacerbates cognitive impairments, which are reversed by a mannose-free diet or mannose transporter antagonists. Mechanistically, single-cell RNA sequencing and metabolomics suggested that mannose-mediated N-glycosylation of BACE1 and Nicastrin enhances their protein stability, promoting Aβ production. Additionally, reduced mannose intake decreased BACE1 and Nicastrin stability, ultimately lowering Aβ production and mitigating AD pathology. this results highlight that high-dose mannose consumption may exacerbate AD pathogenesis. Restricting dietary mannose may have therapeutic benefits.}, archive = {J_ADVS}, author = {Chensi Liang and Ziqi Yuan and Shangchen Yang and Yufei Zhu and Zhenlei Chen and Dan Can and Aiyu Lei and Huifang Li and Lige Leng and Jie Zhang}, doi = {10.1002/advs.202409105}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2409105}, shortjournal = {Adv. Sci.}, title = {Mannose promotes β-amyloid pathology by regulating BACE1 glycosylation in alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Nanotherapies based on ROS regulation in oral diseases. ADVS, 12(9), 2409087. (www)

  @article{ , abstract = {Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. Due to their enzyme-like catalytic properties, unique composition, and intelligent design, ROS-based nanomaterials have garnered considerable attention in oral nanomedicine. Such nanomaterials have the capacity to influence the spatiotemporal dynamics of ROS within biological systems, guiding the evolution of intra-ROS to facilitate therapeutic interventions. This paper reviews the latest advancements in the design, functional customization, and oral medical applications of ROS-based nanomaterials. Through the analysis of the components and designs of various novel nanozymes and ROS-based nanoplatforms responsive to different stimuli dimensions, it elaborates on their impacts on the dynamic behavior of intra-ROS and their potential regulatory mechanisms within the body. Furthermore, it discusses the prospects and strategies of nanotherapies based on ROS scavenging and generation in oral diseases, offering alternative insights for the design and development of nanomaterials for treating ROS-related conditions.}, archive = {J_ADVS}, author = {Xin Luo and Yanli Zhang and Yuting Zeng and Dehong Yang and Zhiyan Zhou and Ziting Zheng and Ping Xiao and Xian Ding and Qianlin Li and Jiaping Chen and Qianwen Deng and Xincen Zhong and Sijie Qiu and Wenjuan Yan}, doi = {10.1002/advs.202409087}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2409087}, shortjournal = {Adv. Sci.}, title = {Nanotherapies based on ROS regulation in oral diseases}, volume = {12}, year = {2025}, }
• (2025). Photothermal coating on zinc alloy for controlled biodegradation and improved osseointegration. ADVS, 12(9), 2409051. (www)

  @article{ , abstract = {Zinc (Zn) and its alloys are promising biomaterials for orthopedic applications due to their degradability and mechanical properties. Zn 2+ plays a crucial role in bone formation, but excessive early release may cause cytotoxicity and inhibit osseointegration. To solve this, we developed a near-infrared (NIR) light-controlled polycaprolactone/copper-sulfur (PCL/CuS) coating that slows degradation and enhances osseointegration of Zn alloys. The zinc–lithium (Zn–Li) substrate is encapsulated with PCL, reducing Zn 2+ release and maintaing biocompatibility. Controlled Zn 2+ release and mild photothermal therapy via CuS nanoparticles promoted osteogenesis. In vitro studies demonstrated enhanced cell proliferation and osteogenic differentiation. In vivo Micro-Computed Tomography (Micro-CT), Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS), and immunohistochemical analyses confirmed improved osseointegration. Mechanistic studies using RNA sequencing and Western blotting revealed that the coating promotes osteogenesis by activating the Wnt/β-catenin and inhibiting NF-κB pathways. This NIR light-controlled PCL/CuS coating successfully regulates Zn alloy degradation, enhances osseointegration via controlled Zn 2+ release and mild photothermal therapy effct, presenting a promising avenue for orthopedic biomaterials.}, archive = {J_ADVS}, author = {Yuchien Hsu and Yunjiao He and Xiao Zhao and Feilong Wang and Fan Yang and Yufeng Zheng and Yongsheng Zhou and Dandan Xia and Yunsong Liu}, doi = {10.1002/advs.202409051}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2409051}, shortjournal = {Adv. Sci.}, title = {Photothermal coating on zinc alloy for controlled biodegradation and improved osseointegration}, volume = {12}, year = {2025}, }
• (2025). Automated and efficient sampling of chemical reaction space. ADVS, 12(9), 2409009. (www)

  @article{ , abstract = {Machine learning interatomic potentials (MLIPs) promise quantum-level accuracy at classical force field speeds, but their performance hinges on the quality and diversity of training data. An efficient and fully automated approach to sample chemical reaction space without relying on human intuition, addressing a critical gap in MLIP development is presented. The method combines the speed of tight-binding calculations with selective high-level refinement, generating diverse datasets that capture both equilibrium and reactive regions of potential energy surfaces. By employing single-ended growing string and nudged elastic band methods, reaction pathways previously underrepresented in MLIP training sets, particularly near transition states are systematically explored. This approach yields datasets with rich structural and chemical diversity, essential for robust MLIP development. Open-source code is provided for the entire workflow, facilitating the integration of the approach into existing MLIP development pipelines.}, archive = {J_ADVS}, author = {Minhyeok Lee and Umit V. Ucak and Jinyoung Jeong and Islambek Ashyrmamatov and Juyong Lee and Eunji Sim}, doi = {10.1002/advs.202409009}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2409009}, shortjournal = {Adv. Sci.}, title = {Automated and efficient sampling of chemical reaction space}, volume = {12}, year = {2025}, }
• (2025). A one stone three birds paradigm of photon-driven pyroptosis dye for amplifying tumor immunotherapy. ADVS, 12(9), 2409007. (www)

  @article{ , abstract = {Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER-centric imaging and therapeutics. Herein, using the targeted group-assisted strategy (TAGS), an intriguing cyclooxygenase-2-targeted photodynamic conjugate, Indo-Cy , strategically created, which exploits the enzyme's overabundance in the tumoral ER, especially under proinflammatory hypoxic conditions. This conjugate, with its highly precise ER imaging, embodies a trifunctional strategy: i) innovating an electron transfer mechanism, converting the hemicyanine moiety into an oxygen-independent type I photosensitizer, thereby navigating around the hypoxia constraints of traditional PDT; ii) executing precise ER-targeted PDT, amplifying caspase-1/GSDMD-mediated pyroptosis for ICD; 3) attenuating immunosuppressive pathways by inhibiting cyclooxygenase-2 downstream factors, including HIF-1α, PGE2, and VEGF. Indo-Cy 's multimodal approach potently induces in vivo tumor pyroptosis and bolsters antitumor immunity, underscoring cyclooxygenase-2-targeted dyes' potential as a versatile oncotherapeutics.}, archive = {J_ADVS}, author = {Shuang Zeng and Chen Chen and Dan Yu and Maojun Jiang and Xin Li and Xiaosheng Liu and Zhihan Guo and Yifu Hao and Danhong Zhou and Heejeong Kim and Heemin Kang and Jingyun Wang and Qixian Chen and Haidong Li and Xiaojun Peng and Juyoung Yoon}, doi = {10.1002/advs.202409007}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2409007}, shortjournal = {Adv. Sci.}, title = {A one stone three birds paradigm of photon-driven pyroptosis dye for amplifying tumor immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Peptide-perovskite based bio-inspired materials for optoelectronics applications. ADVS, 12(9), 2408919. (www)

  @article{ , abstract = {The growing demand for environmentally friendly semiconductors that can be tailored and developed easily is compelling researchers and technologists to design inherently bio-compatible, self-assembling nanostructures with tunable semiconducting characteristics. Peptide-based bioinspired materials exhibit a variety of supramolecular morphologies and have the potential to function as organic semiconductors. Such biologically or naturally derived peptides with intrinsic semiconducting characteristics create new opportunities for sustainable biomolecule-based optoelectronics devices. Affably, halide perovskite nanocrystals are emerging as potentially attractive nano-electronic analogs, in this vein creating synergies and probing peptide-perovskite-based bio-electronics are of paramount interest. The physical properties and inherent aromatic short-peptide assemblies that can stabilize, and passivate the defects at surfaces assist in improving the charge transport in halide perovskite devices. This review sheds light on how these peptide-perovskite nano-assemblies can be developed for optical sensing, optoelectronics, and imaging for biomedical and healthcare applications. The charge transfer mechanism in peptides along with as an outlook the electron transfer mechanism between perovskite and short peptide chains, which is paramount to facilitate their entry into molecular electronics is discussed. Future aspects, prevailing challenges, and research directions in the field of perovskite-peptides are also presented}, archive = {J_ADVS}, author = {Samrana Kazim and M. P. U. Haris and Shahzada Ahmad}, doi = {10.1002/advs.202408919}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2408919}, shortjournal = {Adv. Sci.}, title = {Peptide-perovskite based bio-inspired materials for optoelectronics applications}, volume = {12}, year = {2025}, }
• (2025). StretchView – A multi-axial cell-stretching device for long-term automated videomicroscopy of living cells. ADVS, 12(9), 2408853. (www)

  @article{ , abstract = {Incorporating mechanical stretching of cells in tissue culture is crucial for mimicking (patho)-physiological conditions and understanding the mechanobiological responses of cells, which can have significant implications in areas like tissue engineering and regenerative medicine. Despite the growing interest, most available cell-stretching devices are not compatible with automated live-cell imaging, indispensable for characterizing alterations in the dynamics of various important cellular processes. In this work, StretchView is presented, a multi-axial cell-stretching platform compatible with automated, time-resolved live-cell imaging. Using StretchView, long-term image acquisition of cells in the relaxed and stretched states is shown for the first time (experimental time of 12 h) without the need for human intervention. Homogeneous and stable strain fields are demonstrated for 18 h of cyclic stretching, highlighting the platform's versatility and robustness. As proof-of-principle, the effect of stretching on cell kinematics and spatiotemporal localization of the cell-cell adhesion protein E-cadherin is examined for MDCK cells in monolayer. First evidence of a monotonic increase in junctional E-cadherin localization upon exposure to stretch is presented using live-cell imaging data acquired during cyclic stretching, suggestive of an increase in barrier integrity of the monolayer. These findings highlight the potential of StretchView in providing insights into cell mechanobiology and beyond.}, archive = {J_ADVS}, author = {David Jaworski and Lara Hundsdorfer and Effie Bastounis and Iordania Constantinou}, doi = {10.1002/advs.202408853}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2408853}, shortjournal = {Adv. Sci.}, title = {StretchView – A multi-axial cell-stretching device for long-term automated videomicroscopy of living cells}, volume = {12}, year = {2025}, }
• (2025). Supramolecular engineering of nanoceria for management and amelioration of age-related macular degeneration via the two-level blocking of oxidative stress and inflammation. ADVS, 12(9), 2408436. (www)

  @article{ , abstract = {Age-related macular degeneration (AMD), characterized by choroidal neovascularization (CNV), is the global leading cause of irreversible blindness. Current first-line therapeutics, vascular endothelial growth factor (VEGF) antagonists, often yield incomplete and suboptimal vision improvement, necessitating the exploration of novel and efficacious therapeutic approaches. Herein, a supramolecular engineering strategy to construct moringin (MOR) loaded α-cyclodextrin (α-CD) coated nanoceria (M@CCNP) is constructed, where the hydroxy and newly formed carbonyl groups of α-CD interact with the nanoceria surface via O─Ce conjunction and the isothiocyanate group of MOR inserts deeply into the α-CD cavity via host–guest interaction. By exploiting the recycling reactive oxygen species (ROS) scavenging capability of nanoceria and the anti-inflammation properties of MOR, the two-level strike during AMD pathogenesis can be precisely blocked by M@CCNP. Remarkably, excellent therapeutic efficacy to CNV is observed in vivo, achieving over 80% reduction in neovascularization and over 60% reduction in leakage area. In summary, the supramolecular engineered nanoceria provides an efficient approach for amelioration of AMD by blocking the two-level strike, and presents significant potential as an exceptional drug delivery platform, particularly for ROS-related diseases.}, archive = {J_ADVS}, author = {Mingyu Xu and Yifan Zhou and Yufeng Xu and An Shao and Haijie Han and Juan Ye}, doi = {10.1002/advs.202408436}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2408436}, shortjournal = {Adv. Sci.}, title = {Supramolecular engineering of nanoceria for management and amelioration of age-related macular degeneration via the two-level blocking of oxidative stress and inflammation}, volume = {12}, year = {2025}, }
• (2025). Multi-material electrohydrodynamic printing of bioelectronics with sub-microscale 3D gold pillars for in vitro extra- and intra-cellular electrophysiological recordings. ADVS, 12(9), 2407969. (www)

  @article{ , abstract = {Micro/nanoscale 3D bioelectrodes gain increasing interest for electrophysiological recording of electroactive cells. Although 3D printing has shown promise to flexibly fabricate 3D bioelectronics compared with conventional microfabrication, relatively-low resolution limits the printed bioelectrode for high-quality signal monitoring. Here, a novel multi-material electrohydrodynamic printing (EHDP) strategy is proposed to fabricate bioelectronics with sub-microscale 3D gold pillars for in vitro electrophysiological recordings. EHDP is employed to fabricate conductive circuits for signal transmission, which are passivated by polyimide via extrusion-based printing. Laser-assisted EHDP is developed to produce 3D gold pillars featuring a diameter of 0.64 ± 0.04 µm. The 3D gold pillars demonstrate stable conductivity under the cell-culture environment. Living cells can conformally grow onto these sub-microscale 3D pillars with a height below 5 µm, which facilitates the highly-sensitive recording of extracellular signals with amplitudes <15 µV. The 3D pillars can apply electroporation currents to reversibly open the cellular membrane for intracellular recording, facilitating the measurement of subtle cellular electrophysiological activities. As a proof-of-concept demonstration, fully-printed chips with multiple culturing chambers and sensing bioelectronics are fabricated for zone-specific electrophysiological recording in drug testing. The proposed multi-material EHDP strategy enables rapid prototyping of organ-on-a-chip systems with 3D bioelectronics for high-quality electrophysiological recordings.}, archive = {J_ADVS}, author = {Bingsong Gu and Qihang Ma and Jiaxin Li and Wangkai Xu and Yuke Xie and Peng Lu and Kun Yu and Ziyao Huo and Xiao Li and Jianhua Peng and Yong Jiang and Dichen Li and Jiankang He}, doi = {10.1002/advs.202407969}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2407969}, shortjournal = {Adv. Sci.}, title = {Multi-material electrohydrodynamic printing of bioelectronics with sub-microscale 3D gold pillars for in vitro extra- and intra-cellular electrophysiological recordings}, volume = {12}, year = {2025}, }
• (2025). Immunometabolism of liver xenotransplantation and prospective solutions. ADVS, 12(9), 2407610. (www)

  @article{ , abstract = {End-stage liver diseases, such as hepatocellular carcinoma or acute liver failure, critically necessitate liver transplantation. However, the shortage of available organ donors fails to meet the rapidly growing transplantation demand. Due to the high similarity of liver tissue structure and metabolism between miniature pigs and humans, xenotransplantation of pig livers is considered as a potentially viable solution to organ scarcity. In the 2024, teams from China first time have successfully transplanted a genetically modified Bama miniature pig liver into a clinically brain-dead man lasting for 10 days. This milestone in human xenotransplantation research not only confirms the feasibility of clinical application of xenotransplantation, but also underscores the daunting and protracted nature of this pathway. Despite advanced gene-editing technologies theoretically circumventing the occurrence of most transplant rejection reactions, patients still face challenges such as chronic immune rejection, coagulation disorders, and thrombotic microangiopathy after receiving xenografts. Moreover, prolonged use of immunosuppressive drugs may induce irreversible immune dysfunction, leading to opportunistic infections and metabolic disorders. This article compares the similarities and differences in livers between humans and pigs, summarizes the immunometabolism of xenotransplantation based on current findings, and provides research perspectives on pre-transplantation and post-transplantation strategies for prolonging the survival time of xenografts.}, archive = {J_ADVS}, author = {Shoulong Deng and Yi Zhang and Shasha Shen and Chongyang Li and Chuan Qin}, doi = {10.1002/advs.202407610}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2407610}, shortjournal = {Adv. Sci.}, title = {Immunometabolism of liver xenotransplantation and prospective solutions}, volume = {12}, year = {2025}, }
• (2025). Unseen threats: The long-term impact of PET-microplastics on development of male reproductive over a lifetime. ADVS, 12(9), 2407585. (www)

  @article{ , abstract = {The physical abrasion of plastics from simple everyday entered the food chain, with associated risks recently emphasized. Although many studies have reported the adverse effects of microplastics (MPs) on human, the reproductive implications of continuous exposure to physically abraded polyethylene terephthalate (PET)-MPs remain unexplored. Ingestion of physically abraded PET-MPs (size range: 50–100 µm) in mice from 5 to 34 weeks of age at an annual intake relevant dose of MPs (5 mg week −1 ) significantly impaired male reproductive function. Reductions in seminiferous tubule diameter and epithelial height are observed ( p < 0.0001), with 32.2% decrease in Leydig cells and 24.3% reduction in testosterone levels ( p < 0.05). The epididymis shows marked deterioration in all regions, with total sperm concentration significantly reduce from 17.0 × 10⁶ to 5.3 × 10⁶ ( p < 0.01) and decrease motility. Transcriptome analysis demonstrates downregulation of genes related with gonadotropin-releasing hormone secretion, testosterone biosynthesis, and Meiosin gene, which is for crucial spermatogenesis. Continuous ingestion of physically abraded PET-MPs from plastic bottles adversely affected testicular and epididymal functions, leading to hormonal imbalances and abnormal sperm production. These findings raise concerns about the impact of commonly used plastics on male reproductive development, highlighting potential risks for future generations.}, archive = {J_ADVS}, author = {Seungjin Jeong and GyuDae Lee and Surye Park and Myeongjoo Son and Seungjun Lee and Bomi Ryu}, doi = {10.1002/advs.202407585}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2407585}, shortjournal = {Adv. Sci.}, title = {Unseen threats: The long-term impact of PET-microplastics on development of male reproductive over a lifetime}, volume = {12}, year = {2025}, }
• (2025). Precise sizing and collision detection of functional nanoparticles by deep learning empowered plasmonic microscopy. ADVS, 12(9), 2407432. (www)

  @article{ , abstract = {Single nanoparticle analysis is crucial for various applications in biology, materials, and energy. However, precisely profiling and monitoring weakly scattering nanoparticles remains challenging. Here, it is demonstrated that deep learning-empowered plasmonic microscopy (Deep-SM) enables precise sizing and collision detection of functional chemical and biological nanoparticles. Image sequences are recorded by the state-of-the-art plasmonic microscopy during single nanoparticle collision onto the sensor surface. Deep-SM can enhance signal detection and suppresses noise by leveraging spatio-temporal correlations of the unique signal and noise characteristics in plasmonic microscopy image sequences. Deep-SM can provide significant scattering signal enhancement and noise reduction in dynamic imaging of biological nanoparticles as small as 10 nm, as well as the collision detection of metallic nanoparticle electrochemistry and quantum coupling with plasmonic microscopy. The high sensitivity and simplicity make this approach promising for routine use in nanoparticle analysis across diverse scientific fields.}, archive = {J_ADVS}, author = {Jingan Wang and Yi Sun and Yuting Yang and Cheng Zhang and Weiqiang Zheng and Chen Wang and Wei Zhang and Lianqun Zhou and Hui Yu and Jinghong Li}, doi = {10.1002/advs.202407432}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2407432}, shortjournal = {Adv. Sci.}, title = {Precise sizing and collision detection of functional nanoparticles by deep learning empowered plasmonic microscopy}, volume = {12}, year = {2025}, }
• (2025). The primary cilia are associated with the axon initial segment in neurons. ADVS, 12(9), 2407405. (www)

  @article{ , abstract = {The primary cilia serve as pivotal mediators of environmental signals and play crucial roles in neuronal responses. Disruption of ciliary function has been implicated in neuronal circuit disorders and aberrant neuronal excitability. However, the precise mechanisms remain elusive. To study the link between the primary cilia and neuronal excitability, manipulation of somatostatin receptor 3 (SSTR3) is investigated, as an example of how alterations in ciliary signaling may affect neuronal activity. It is found that aberrant SSTR3 expression perturbed not only ciliary morphology but also disrupted ciliary signaling cascades. Genetic deletion of SSTR3 resulted in perturbed spatial memory and synaptic plasticity. The axon initial segment (AIS) is a specialized region in the axon where action potentials are initiated. Interestingly, loss of ciliary SSTR3 led to decrease of Akt-dependent cyclic AMP-response element binding protein (CREB)-mediated transcription at the AIS, specifically downregulating AIS master organizer adaptor protein ankyrin G (AnkG) expression. In addition, alterations of other ciliary proteins serotonin 6 receptor (5-HT6R)and intraflagellar transport protein 88 (IFT88) also induced length changes of the AIS. The findings elucidate a specific interaction between the primary cilia and AIS, providing insight into the impact of the primary cilia on neuronal excitability and circuit integrity.}, archive = {J_ADVS}, author = {Han Wang and Yu Li and Xin Li and Zehui Sun and Fengdan Yu and Abolghasem Pashang and Don Kulasiri and Hung Wing Li and Huan Chen and Hongwei Hou and Yan Zhang}, doi = {10.1002/advs.202407405}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2407405}, shortjournal = {Adv. Sci.}, title = {The primary cilia are associated with the axon initial segment in neurons}, volume = {12}, year = {2025}, }
• (2025). Constructing activatable photosensitizers using covalently modified mesoporous silica. ADVS, 12(9), 2406887. (www)

  @article{ , abstract = {The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy and broaden their applicability. However, the current nanocarrier-based delivery strategies focus on conventional PSs, neglecting the critical issue of PS phototoxicity. In this study, DHUOCl-25, an activatable PS (aPS) activated by hypochlorous acid, is synthesized by combining a silicon source structure and an activation unit. DHUOCl-25 functions as a silica source for synthesizing activatable mesoporous silica nanostrctures (MSNs) using a standardized protocol, enabling the synthesis of aPS-covalently modified MSNs for a variety of biologic therapeutic applications. On one hand, the resulting nano-aPS maintains aPS functionality for antibacterial application by achieving synergistic antibacterial action via MB PDT and retained cetyltrimethylammonium bromide (CTAB) (antibacterial agent) (DHU–MSNs-2). On the other hand, the nano-aPS exhibits MSN properties for drug loading, facilitating the synergistic integration of photodynamic therapy with chemotherapy (DHU–MSNs-6) of tumors and demonstrating efficacy against the spinal metastases of lung cancer. These results validate this strategy for developing novel aPSs and expanding the application of aPSs and MSNs.}, archive = {J_ADVS}, author = {Yan Liu and Xiang Wang and Ben Wang and Zhenni Lu and Changru Wu and Zhanghao He and Libo Jiang and Peng Wei and Tao Yi}, doi = {10.1002/advs.202406887}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2406887}, shortjournal = {Adv. Sci.}, title = {Constructing activatable photosensitizers using covalently modified mesoporous silica}, volume = {12}, year = {2025}, }
• (2025). Temporal lobe epilepsy perturbs the brain-wide excitation-inhibition balance: Associations with microcircuit organization, clinical parameters, and cognitive dysfunction. ADVS, 12(9), 2406835. (www)

  @article{ , abstract = {Excitation-inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with ample research focusing on elucidating its cellular manifestations. However, few studies investigate E/I imbalance at the macroscale, whole-brain level, and its microcircuit-level mechanisms and clinical significance remain incompletely understood. Here, the Hurst exponent, an index of the E/I ratio, is computed from resting-state fMRI time series, and microcircuit parameters are simulated using biophysical models. A broad decrease in the Hurst exponent is observed in pharmaco-resistant temporal lobe epilepsy (TLE), suggesting more excitable network dynamics. Connectome decoders point to temporolimbic and frontocentral cortices as plausible network epicenters of E/I imbalance. Furthermore, computational simulations reveal that enhancing cortical excitability in TLE reflects atypical increases in recurrent connection strength of local neuronal ensembles. Mixed cross-sectional and longitudinal analyses show stronger E/I ratio elevation in patients with longer disease duration, more frequent electroclinical seizures as well as interictal epileptic spikes, and worse cognitive functioning. Hurst exponent-informed classifiers discriminate patients from healthy controls with high accuracy (72.4% [57.5%–82.5%]). Replicated in an independent dataset, this work provides in vivo evidence of a macroscale shift in E/I balance in TLE patients and points to progressive functional imbalances that relate to cognitive decline.}, archive = {J_ADVS}, author = {Ke Xie and Jessica Royer and Raul Rodriguez-Cruces and Linda Horwood and Alexander Ngo and Thaera Arafat and Hans Auer and Ella Sahlas and Judy Chen and Yigu Zhou and Sofie L. Valk and Seok-Jun Hong and Birgit Frauscher and Raluca Pana and Andrea Bernasconi and Neda Bernasconi and Luis Concha and Boris C. Bernhardt}, doi = {10.1002/advs.202406835}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2406835}, shortjournal = {Adv. Sci.}, title = {Temporal lobe epilepsy perturbs the brain-wide excitation-inhibition balance: Associations with microcircuit organization, clinical parameters, and cognitive dysfunction}, volume = {12}, year = {2025}, }
• (2025). ShK-modified UCMSCs inhibit m1-like macrophage polarization and alleviate osteoarthritis progression via PI3K/Akt axis. ADVS, 12(9), 2406822. (www)

  @article{ , abstract = {The potassium channel Kv1.3 plays an important role in regulating immune cell functions in many inflammatory diseases whereas rarely in osteoarthritis (OA). Here, it is demonstrated that the Kv1.3 of macrophages is upregulated in response to LPS stimulation, as well as in human OA synovium samples than non-OA. Administration of Stichodactyla toxin (ShK), a Kv1.3 blocker, significantly inhibited cartilage degeneration and synovial inflammation in animal models of OA in vivo by inhibiting M1 macrophage polarization and reducing the production of inflammatory factors. In this study, a transgenically engineered human umbilical cord mesenchymal stem cell (UCMSC) delivery system is developed that secreted a peptide ShK, a Kv1.3 potassium blocker, into the knee articular cavity. Collectively, the results identified Kv1.3 as a potential therapeutic target for OA and demonstrated the efficacy of using ShK transgenic engineered UCMSCs as a delivery for the peptide in OA treatment.}, archive = {J_ADVS}, author = {Wenshu Wu and Xueying An and Wang Gong and Lin Yang and Na Liu and Bin Liu and Baosheng Guo and Qing Jiang and Lan Li}, doi = {10.1002/advs.202406822}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2406822}, shortjournal = {Adv. Sci.}, title = {ShK-modified UCMSCs inhibit m1-like macrophage polarization and alleviate osteoarthritis progression via PI3K/Akt axis}, volume = {12}, year = {2025}, }
• (2025). Proximity labeling and genetic screening reveal that DSG2 is a counter receptor of siglec-9 and suppresses macrophage phagocytosis. ADVS, 12(9), 2406654. (www)

  @article{ , abstract = {Cancer cells present sialylated glycoconjugates that modulate the activity of various immune cells within the tumor microenvironment through trans interaction with immunosuppressive Siglec receptors. Identifying counter receptors for Siglecs can provide valuable targets for cancer immunotherapy, but it presents significant challenges. Here, the identification of DSG2 (Desmoglein 2) as a dominant counter receptor of Siglec-9 in melanoma cells is reported, using a workflow that combines the strength of proximity labeling and the advantage of CRISPR knockout screening. It is further demonstrated that the interaction between DSG2 and Siglec-9 is mainly dependent on sialic acid-bearing N -glycans on DSG2. Importantly, blocking trans interaction between DSG2 and Siglec-9 significantly enhances macrophage phagocytosis of melanoma cells and, to a lesser extent, other cancer cells. The work thus suggests sialylated DSG2 as a potential “don't eat me” signal molecule with therapeutic potentials in cancer immunotherapy.}, archive = {J_ADVS}, author = {Ying Wu and Yuyu You and Tingsong Jiang and Yuqi He and Qingchi Fan and Xinlei Zeng and Ting Li and Yuxing Lu and Liang Qi and Fengxia Zhou and Lingyu Sun and Danyang Wang and Yong Zou and Guigen Zhang and Yanqiu Yuan and Yang Mao}, doi = {10.1002/advs.202406654}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2406654}, shortjournal = {Adv. Sci.}, title = {Proximity labeling and genetic screening reveal that DSG2 is a counter receptor of siglec-9 and suppresses macrophage phagocytosis}, volume = {12}, year = {2025}, }
• (2025). Molecular clip strategy of modified sulfur cathodes for high-performance potassium sulfur batteries. ADVS, 12(9), 2405457. (www)

  @article{ , abstract = {Potassium-sulfur (K-S) batteries are severely limited by the sluggish reaction kinetics of the cyclooctasulfur (cyclo-S 8 ) electrode with low conductivity, which urgently requires a novel cathode to facilitate activity to improve sulfur utilization. In this study, using the wet chemistry method, the molecular clip of Li + is created to replace cyclo-S 8 molecular with the highly active chain-like S 6 2− molecular. The molecular clip strategy effectively lowers the reaction barrier in potassium-sulfur systems, and the stretching of S─S bonds weakens the binding between sulfur atoms, facilitating the transformation of potassium polysulfides (KPSs). The as-prepared cathode exhibits a reversible capacity of 894.8 mAh g −1 at a current rate of 0.5 C. It maintains a long cycle life of 1000 cycles with a stable coulombic efficiency in the potassium–sulfur cells without cathode catalysts. Operando XRD and Raman spectra combined with density functional theory (DFT) calculations, revealing the high efficiency of enhanced conversion of potassium polysulfide for high-performance K-S batteries.}, archive = {J_ADVS}, author = {Tianyu Chen and Zhiwen Min and Zhenjiang Yu and Mengting Zheng and Qingbin Jiang and Huifang Xu and Yuanmiao Sun and Kwan San Hui and Chenyang Zha and Jun Lu and Kwun Nam Hui}, doi = {10.1002/advs.202405457}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2405457}, shortjournal = {Adv. Sci.}, title = {Molecular clip strategy of modified sulfur cathodes for high-performance potassium sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). Exploring new bioorthogonal catalysts: Scaffold diversity in catalysis for chemical biology. ADVS, 12(9), 2404431. (www)

  @article{ , abstract = {Bioorthogonal catalysis has revolutionized the field of chemical biology by enabling selective and controlled chemical transformations within living systems. Research has converged on the development of innovative catalyst scaffolds, seeking to broaden the scope of bioorthogonal reactions, boost their efficiency, and surpass the limitations of conventional catalysts. This review provides a comprehensive overview of the latest advancements in bioorthogonal catalyst research based on different scaffold materials. Through an in-depth analysis of fabrication strategies and applications of bioorthogonal catalysts, this review discusses the design principles, mechanisms of action, and applications of these novel catalysts in chemical biology. Current challenges and future directions in exploring the scaffold diversity are also highlighted. The integration of diverse catalyst scaffolds offers exciting prospects for precise manipulation of biomolecules and the development of innovative therapeutic strategies in chemical biology. In addition, the review fills in the gaps in previous reviews, such as in fully summarizing the presented scaffold materials applied in bioorthogonal catalysts, emphasizing the potential impact on advancing bioorthogonal chemistry, and offering prospects for future development in this field.}, archive = {J_ADVS}, author = {Yan Zhang and Qizhen Huang and Fang Lei and Wanlong Qian and Chengfeng Zhang and Qi Wang and Chaoqun Liu and Haiwei Ji and Faming Wang}, doi = {10.1002/advs.202404431}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2404431}, shortjournal = {Adv. Sci.}, title = {Exploring new bioorthogonal catalysts: Scaffold diversity in catalysis for chemical biology}, volume = {12}, year = {2025}, }
• (2025). The environmental impact of medical imaging agents and the roadmap to sustainable medical imaging. ADVS, 12(9), 2404411. (www)

  @article{ , abstract = {Medical imaging agents, i.e., contrast agents for magnetic resonance imaging (MRI) and radiopharmaceuticals, play a vital role in the diagnosis of diseases. Yet, they mostly contain harmful and non-biodegradable substances, such as per- and polyfluoroalkyl substances (PFAS), heavy metals or radionuclides. As a result of their increasing clinical use, these agents are entering various water bodies and soil, posing risks to environment and human health. Here, the environmental effects of the application of imaging agents are outlined for the major imaging modalities, and the respective chemistry of the contrast agents with environmental implications is linked. Recommendations are introduced for the design and application of contrast agents: the 3Cs of imaging agents: control, change, and combine; and recent approaches for more sustainable imaging strategies are highlighted. This combination of measures should engage an open discussion, inspire solutions to reduce pollution by imaging agents, and increase awareness for the impact of toxic waste related to imaging agents.}, archive = {J_ADVS}, author = {Verena Pichler and Ricardo P. Martinho and Lisanne Temming and Tim Segers and Frederik R. Wurm and Olga Koshkina}, doi = {10.1002/advs.202404411}, journal = {Advanced Science}, month = {3}, number = {9}, pages = {2404411}, shortjournal = {Adv. Sci.}, title = {The environmental impact of medical imaging agents and the roadmap to sustainable medical imaging}, volume = {12}, year = {2025}, }
• (2025). Attractor landscape analysis reveals a reversion switch in the transition of colorectal tumorigenesis (Adv. sci. 8/2025). ADVS, 12(8), 2570051. (www)

  @article{ , archive = {J_ADVS}, author = {Dongkwan Shin and Jeong-Ryeol Gong and Seoyoon D. Jeong and Youngwon Cho and Hwang-Phill Kim and Tae-You Kim and Kwang-Hyun Cho}, doi = {10.1002/advs.202570051}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2570051}, shortjournal = {Adv. Sci.}, title = {Attractor landscape analysis reveals a reversion switch in the transition of colorectal tumorigenesis (Adv. sci. 8/2025)}, volume = {12}, year = {2025}, }
• (2025). A novel RAGE modulator induces soluble RAGE to reduce BACE1 expression in alzheimer's disease (Adv. sci. 8/2025). ADVS, 12(8), 2570050. (www)

  @article{ , archive = {J_ADVS}, author = {Seung-Hyun Baek and Suji Hong and Eunae Kim and Sunyoung Park and Minyoung Lee and Jinsu Park and Yoonsuk Cho and Hyunjun Yoon and Daeseung Kim and Youngkwang Yun and Youbin Kim and Yoonjung Choi and Keunsoo Kang and Sangyong Jung and Jun Pyo Kim and Eunha Kim and Sang Won Seo and Yong-Keun Jung and Dong-Gyu Jo}, doi = {10.1002/advs.202570050}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2570050}, shortjournal = {Adv. Sci.}, title = {A novel RAGE modulator induces soluble RAGE to reduce BACE1 expression in alzheimer's disease (Adv. sci. 8/2025)}, volume = {12}, year = {2025}, }
• (2025). Matrix-rigidity cooperates with biochemical cues in m2 macrophage activation through increased nuclear deformation and chromatin accessibility (Adv. sci. 8/2025). ADVS, 12(8), 2570049. (www)

  @article{ , archive = {J_ADVS}, author = {Seung Jae Shin and Buuvee Bayarkhangai and Khaliunsarnai Tsogtbaatar and Meng Yuxuan and Sang-Hyun Kim and Yong-Jae Kim and Ali Taghizadeh and Daesan Kim and Dong-Hwee Kim and Jung-Hwan Lee and Jeongeun Hyun and Hae-Won Kim}, doi = {10.1002/advs.202570049}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2570049}, shortjournal = {Adv. Sci.}, title = {Matrix-rigidity cooperates with biochemical cues in m2 macrophage activation through increased nuclear deformation and chromatin accessibility (Adv. sci. 8/2025)}, volume = {12}, year = {2025}, }
• (2025). Pathophysiology-directed engineering of a combination nanoanalgesic for neuropathic pain (Adv. sci. 8/2025). ADVS, 12(8), 2570047. (www)

  @article{ , archive = {J_ADVS}, author = {Wenkai Wang and Yan Wang and Xinle Huang and Peng Wu and Lanlan Li and Yang Zhang and Yihui Chen and Zhiyu Chen and Changqing Li and Yue Zhou and Jianxiang Zhang}, doi = {10.1002/advs.202570047}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2570047}, shortjournal = {Adv. Sci.}, title = {Pathophysiology-directed engineering of a combination nanoanalgesic for neuropathic pain (Adv. sci. 8/2025)}, volume = {12}, year = {2025}, }
• (2025). Reversible carrier modulation in InP nanolasers by ionic liquid gating with low energy consumption (Adv. sci. 8/2025). ADVS, 12(8), 2570046. (www)

  @article{ , archive = {J_ADVS}, author = {Chia-Hung Wu and Chi-Wen Chen and Hung-Jung Shen and Hsiang-Yu Chuang and Hark Hoe Tan and Chennupati Jagadish and Tien-Chang Lu and Satoshi Ishii and Kuo-Ping Chen}, doi = {10.1002/advs.202570046}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2570046}, shortjournal = {Adv. Sci.}, title = {Reversible carrier modulation in InP nanolasers by ionic liquid gating with low energy consumption (Adv. sci. 8/2025)}, volume = {12}, year = {2025}, }
• (2025). Manipulation of surface potential distribution enhances osteogenesis by promoting pro-angiogenic macrophage polarization via activation of the PI3K-akt signaling pathway (Adv. sci. 8/2025). ADVS, 12(8), 2570045. (www)

  @article{ , archive = {J_ADVS}, author = {Qun Cui and Xiaona Zheng and Yunyang Bai and Yaru Guo and Shuo Liu and Yanhui Lu and Lulu Liu and Jia Song and Yang Liu and Boon Chin Heng and Fuping You and Mingming Xu and Xuliang Deng and Xuehui Zhang}, doi = {10.1002/advs.202570045}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2570045}, shortjournal = {Adv. Sci.}, title = {Manipulation of surface potential distribution enhances osteogenesis by promoting pro-angiogenic macrophage polarization via activation of the PI3K-akt signaling pathway (Adv. sci. 8/2025)}, volume = {12}, year = {2025}, }
• (2025). Multifaceted immunomodulatory nanocomplexes target neutrophilic-ROS inflammation in acute lung injury (Adv. sci. 8/2025). ADVS, 12(8), 2570044. (www)

  @article{ , archive = {J_ADVS}, author = {Fan Su and Chong Zhang and Qianyun Zhang and Yi Shen and Saiqi Li and Jianlin Shi and Ya-Xuan Zhu and Han Lin and Bin He}, doi = {10.1002/advs.202570044}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2570044}, shortjournal = {Adv. Sci.}, title = {Multifaceted immunomodulatory nanocomplexes target neutrophilic-ROS inflammation in acute lung injury (Adv. sci. 8/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to [Tumor-associated macrophage-derived exosomes LINC01232 induce the immune escape of glioma by decreasing MHC-I surface expression]. ADVS, 12(8), 2500268. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202500268}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2500268}, shortjournal = {Adv. Sci.}, title = {Correction to [Tumor-associated macrophage-derived exosomes LINC01232 induce the immune escape of glioma by decreasing MHC-I surface expression]}, volume = {12}, year = {2025}, }
• (2025). Correction to “Synergistic activation of antitumor immunity by a particulate therapeutic vaccine”. ADVS, 12(8), 2414927. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202414927}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2414927}, shortjournal = {Adv. Sci.}, title = {Correction to “Synergistic activation of antitumor immunity by a particulate therapeutic vaccine”}, volume = {12}, year = {2025}, }
• (2025). Elucidating manganese single-atom doping: Strategies for fluorescence enhancement in water-soluble red-emitting carbon dots and applications for FL/MR dual mode imaging. ADVS, 12(8), 2414895. (www)

  @article{ , abstract = {The absence of the enhancement of fluorescence in carbon dots (CDs) through doping with transition metal atoms (TMAs) hinders the advancement of multi-modal bio-imaging CDs with high photoluminescence quantum yield (PLQY). Herein, Mn-atomically-doped R-CDs (R-Mn-CDs) with a high PLQY of 41.3% in water is presented, enabling efficient in vivo dual-mode fluorescence/magnetic resonance (MR) imaging. The comprehensive characterizations reveal that the incorporation of Mn atoms leads to a Mn-N 2 O 2 coordinating structure, resulting in five significant effects: an increase in sp 2 conjugation domains, a reduction in band gap, a decreased oxidation level, an increase in photo-excited electron numbers, and the suppression of non-radiative electron relaxation pathways. Collectively, these factors contribute to the remarkable PLQY of R-Mn-CDs. Additionally, the doping of Mn atoms also endows R-Mn-CDs with superior MR imaging capabilities due to, which highlights their promising prospect as a dual-modal bio-imaging platform for fluorescence/MR imaging. Furthermore, the findings indicate that the introduction of various TMAs, such as Mn, Zn, Ni, and Cu, can universally improve the PLQY of water-soluble CDs through the construction of TMAs─O bonds. This research provides valuable theoretical insights into the mechanisms underlying the fluorescence enhancement induced by TMAs doping and offers guidance for the future design of high PLQY CDs.}, archive = {J_ADVS}, author = {Fucheng Gao and Qiang Fu and Ying Ruan and Can Li and Yandong Wang and Hui Li and Jichao Li and Yanyan Jiang}, doi = {10.1002/advs.202414895}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2414895}, shortjournal = {Adv. Sci.}, title = {Elucidating manganese single-atom doping: Strategies for fluorescence enhancement in water-soluble red-emitting carbon dots and applications for FL/MR dual mode imaging}, volume = {12}, year = {2025}, }
• (2025). ECSIT-x4 is required for preventing pressure overload-induced cardiac hypertrophy via regulating mitochondrial STAT3. ADVS, 12(8), 2414358. (www)

  @article{ , abstract = {Mitochondrial dysfunction is a key factor in exacerbating pressure overload-induced cardiac hypertrophy and is linked to increased morbidity and mortality. ECSIT, a crucial adaptor for inflammation and mitochondrial function, has been reported to express multiple transcripts in various species and tissues, leading to distinct protein isoforms with diverse subcellular localizations and functions. However, whether an unknown ECSIT isoform exists in cardiac cells and its potential role in regulating mitochondrial function and pathological cardiac hypertrophy has remained unclear. This study identified a 42-kDa ECSIT isoform encoded by the transcript variant Ecsit-X4, which is highly expressed in the mitochondria of adult cardiomyocytes but down-regulated in hypertrophic human heart samples and TAC-treated mouse hearts. AAV9-mediated Ecsit-X4 gene therapy, administered either before or after TAC surgery, significantly attenuated cardiac hypertrophy. Cardiomyocyte-specific Ecsit deficiency worsened TAC-induced cardiac hypertrophy, while Ecsit-X4 compensation independently rescued hypertrophic phenotypes in Ecsit cKO mice. Mechanistically, ECSIT-X4 localized to the mitochondria and interacted with STAT3, leading to increased STAT3 levels and enhanced serine 727 phosphorylation in cardiomyocyte mitochondria, thereby promoting strong mitochondrial bioenergetics. This study identified a novel transcript variant of ECSIT localized in the mitochondria of adult cardiomyocytes and highlights its potential as a therapeutic target for heart failure.}, archive = {J_ADVS}, author = {Xia Lu and Tingting Tong and Haoliang Sun and Yi Chen and Yongfeng Shao and Pengxi Shi and Linli Que and Li Liu and Guoqing Zhu and Qi Chen and Chuanfu Li and Jiantao Li and Shuo Yang and Yuehua Li}, doi = {10.1002/advs.202414358}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2414358}, shortjournal = {Adv. Sci.}, title = {ECSIT-x4 is required for preventing pressure overload-induced cardiac hypertrophy via regulating mitochondrial STAT3}, volume = {12}, year = {2025}, }
• (2025). Manipulation of surface potential distribution enhances osteogenesis by promoting pro-angiogenic macrophage polarization via activation of the PI3K-akt signaling pathway. ADVS, 12(8), 2414278. (www)

  @article{ , abstract = {Regulation of the immune response is key to promoting bone regeneration by electroactive biomaterials. However, how electrical signals at the micro- and nanoscale regulate the immune response and subsequent angiogenesis during bone regeneration remains to be elucidated. Here, the distinctly different surface potential distributions on charged poly(vinylidene fluoridetrifluoroethylene) (P(VDF-TrFE)) matrix surfaces are established by altering the dimensions of ferroelectric nanofillers from 0D BaTiO 3 nanoparticles (homogeneous surface potential distribution, HOPD) to 1D BaTiO 3 nanofibers (heterogeneous surface potential distribution, HEPD). Compared to HOPD, HEPD is significantly better at inducing the M2 polarization of macrophages and promoting neovascularization, which results in accelerated bone regeneration in vivo. The transcriptomic analysis reveals that macrophages modulated by HEPD display high expression levels of pro-angiogenic genes, which is corroborated by tube-formation assays, RT-qPCR, and western blot analyses in vitro. Mechanistic explorations elucidate activation of the PI3K-Akt signaling pathway, which in turn induces the polarization of macrophages toward a pro-angiogenic phenotype. This study elucidates the cascade of biological processes by which heterogeneous electrical signals at the micro- and nanoscale modulate macrophage functions to promote vascularization and bone regeneration. Hence, this study provides new insights into how the micro- and nanoscale distribution characteristics of electrical signals facilitate bone regeneration.}, archive = {J_ADVS}, author = {Qun Cui and Xiaona Zheng and Yunyang Bai and Yaru Guo and Shuo Liu and Yanhui Lu and Lulu Liu and Jia Song and Yang Liu and Boon Chin Heng and Fuping You and Mingming Xu and Xuliang Deng and Xuehui Zhang}, doi = {10.1002/advs.202414278}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2414278}, shortjournal = {Adv. Sci.}, title = {Manipulation of surface potential distribution enhances osteogenesis by promoting pro-angiogenic macrophage polarization via activation of the PI3K-akt signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Polyethyleneimine-based cryogels enabling the selective and reversible adsorption of chlorine. ADVS, 12(8), 2414274. (www)

  @article{ , abstract = {Herein hyperbranched polyethyleneimine (hPEI) cryogels are reported for the selective and reversible adsorption of elemental chlorine. The cryogels are prepared in an aqueous solution by crosslinking with glutaraldehyde at subzero temperatures. The final macroporous composites bearing ammonium chloride groups are obtained after freeze-drying. The cryogels CG1[Cl]–CG3[Cl] adsorb chlorine with capacities of 0.22–0.26 g Cl 2 /g cryogel as an average over three adsorption-desorption cycles. The adsorption process is based on the reversible and selective halogen bonding of chlorides (Cl − ) with chlorine (Cl 2 ) forming the corresponding trichloride ([Cl 3 ] − ) species, indicated by Raman spectroscopy. The reversibility of chlorine adsorption is shown by applying heat and vacuum to the loaded cryogel CG1[Cl 3 ] releasing 63% of the adsorbed chlorine within 3 h and 72% within 16 h. The unique ability to selectively adsorb chlorine in the presence of other gases is successfully employed for the selective adsorption of chlorine from a gas mixture, potentially enabling the recycling of chlorine from tail gas streams.}, archive = {J_ADVS}, author = {Alejandro Lorente and Johanna S. Sturm and Merlin Kleoff and Fabio Lorenz and Patrick Voßnacker and Olaf Wagner and Rainer Haag and Sebastian Riedel}, doi = {10.1002/advs.202414274}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2414274}, shortjournal = {Adv. Sci.}, title = {Polyethyleneimine-based cryogels enabling the selective and reversible adsorption of chlorine}, volume = {12}, year = {2025}, }
• (2025). Enabling aqueous phase long-lived deep-blue phosphorescence with layered double hydroxide. ADVS, 12(8), 2413896. (www)

  @article{ , abstract = {Aqueous-phase phosphors are of utmost importance for a myriad of applications. However, the emission wavelengths of the current aqueous organic room-temperature phosphorescent (RTP) materials are limited to green and red bands, while the blue part is rarely reported, thus limiting the development of a full-color RTP system. Theoretically, carboxylated benzene is expected to be blue phosphorescence-emissive, but only green phosphorescence is observed in solid, due to the strong intermolecular π–π stacking that decreases the energy gap. Herein, the use of water-dispersible layered double hydroxide (ZnAl-LDH) is proposed for isolating Ph-(COOH) n and the distance between the adjacent chromophores is confirmed to be larger (≈7.0 Å) than the threshold of π–π interaction. Deep-blue phosphorescence with a lifetime over 0.1 s, and a maximum luminescence quantum yield of 42%, is harvested in the aqueous phase. The long-lived deep-blue phosphorescence is successfully explored for high-temperature display and luminescent dyes.}, archive = {J_ADVS}, author = {Qian Chen and Peisheng Cao and Peng Wu}, doi = {10.1002/advs.202413896}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413896}, shortjournal = {Adv. Sci.}, title = {Enabling aqueous phase long-lived deep-blue phosphorescence with layered double hydroxide}, volume = {12}, year = {2025}, }
• (2025). Full-spectrum mechanochromic photonic films with large interparticle distance. ADVS, 12(8), 2413881. (www)

  @article{ , abstract = {Non-close-packed crystalline arrays of colloidal particles in an elastic matrix exhibit mechanochromism. However, small interparticle distances often limit the range of reversible color shifts and reduce reflectivity during a blueshift. A straightforward, reproducible strategy using matrix swelling to increase interparticle distance and improve mechanochromic performance is presented. Photonic composites are initially prepared with silica particle arrays embedded in an elastomer matrix at volume fractions of 0.35–0.5. To increase interparticle distance, the composites are immersed in an elastomer-forming monomer, causing the matrix to swell, followed by photopolymerization, thereby producing liquid-free composites. The degree of swelling is controllable up to 3.16, depending on monomer choice, matrix volume fraction, and crosslinking density. The process can be repeated to further increase swelling up to 10.36. This method can reduce the volume fraction of silica particles from 40% to 3.8%, while interparticle distance increases from 53 to 257 nm. The swollen photonic composites exhibit a full visible spectrum under compression, while minimizing reflectivity loss. This allows red-colored photonic composites to be transformed into vivid multicolor patterns when compressed with stamps featuring spatial height variations.}, archive = {J_ADVS}, author = {Hwan-Young Lee and Jun-Gu Kang and Young-Seok Kim and Shin-Hyun Kim}, doi = {10.1002/advs.202413881}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413881}, shortjournal = {Adv. Sci.}, title = {Full-spectrum mechanochromic photonic films with large interparticle distance}, volume = {12}, year = {2025}, }
• (2025). Unipolar barrier photodetectors based on van der waals heterostructure with ultra-high light On/Off ratio and fast speed. ADVS, 12(8), 2413844. (www)

  @article{ , abstract = {Unipolar barrier architecture is designed to enhance the photodetector's sensitivity by inducing highly asymmetrical barriers, a higher barrier for blocking majority carriers to depressing dark current, and a low minority carrier barrier without impeding the photocurrent flow through the channel. Depressed dark current without block photocurrent is highly desired for uncooled Long-wave infrared (LWIR) photodetection, which can enhance the sensitivity of the photodetector. Here, an excellent unipolar barrier photodetector based on multi-layer (ML) graphene (G) is developed, WSe 2 , and PtSe 2 (G-WSe 2 -PtSe 2 ) van der Waals (vdW) heterostructure, in which extremely low dark current of 1.61×10 −13 A, a record high light on/off ≈10 9 are demonstrated at 0 V. Notably, the device exhibits ultrafast response speed with rise time τ r = 699 ns and decay time τ d = 452 ns and high-power conversion efficiency ( η ) of 4.87%. The heterostructure demonstrates a broadband photoresponse from 365 nm to LWIR 10.6 µm at room temperature. Notably, the G-WSe 2 -PtSe 2 nBn device demonstrates high photoresponsivity ( R ) of 1.8 AW −1 with 10.6 µm laser at 1 V bias in ambient air. This unipolar barrier device architecture offers an alternative way for highly sensitive free space communication.}, archive = {J_ADVS}, author = {Suofu Wang and Xiuxiu Wang and Wenhui Wang and Tao Han and Feng Li and Lei Shan and Mingsheng Long}, doi = {10.1002/advs.202413844}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413844}, shortjournal = {Adv. Sci.}, title = {Unipolar barrier photodetectors based on van der waals heterostructure with ultra-high light On/Off ratio and fast speed}, volume = {12}, year = {2025}, }
• (2025). A dual-targeting biomimetic nanoplatform integrates SDT/CDT/Gas therapy to boost synergistic ferroptosis for orthotopic hepatocellular carcinoma therapy. ADVS, 12(8), 2413833. (www)

  @article{ , abstract = {The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC-targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO-releasing molecules, and further camouflaged with SP94 peptide-modified macrophage membrane for enhanced ferroptosis-driven multi-modal therapy of HCC. Leveraging the multi-enzyme activities of the multivalent metallic elements, the nanoplatform not only decomposes H 2 O 2 to generate oxygen and alleviate tumor hypoxia but also depletes glutathione to inactivate glutathione peroxides 4, which amplify sonodynamic therapy and ferroptotic tumor death under ultrasound (US) irradiation. Meanwhile, the nanoplatform catalyzes the Fenton reaction to produce hydroxyl radicals for chemodynamic therapy. Elevated intracellular reactive oxygen species trigger the cascade release of CO, leading to lethal lipid peroxidation and further enhancing ferroptosis-mediated tumor therapy. This nanoplatform demonstrates robust anti-tumor efficacy under US irradiation with favorable biosafety in both subcutaneous and orthotopic HCC models, representing a promising therapeutic approach for HCC. Additionally, the findings offer new insights into tumor microenvironment modulation to optimize US-triggered multi-modal cancer therapy.}, archive = {J_ADVS}, author = {Wen Meng and Ting Chen and Xueping Li and Yi Li and Lu Zhang and Yigang Xu and Tianqiang Song and Ji Qi and Qingqing Xiong and Wen Li}, doi = {10.1002/advs.202413833}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413833}, shortjournal = {Adv. Sci.}, title = {A dual-targeting biomimetic nanoplatform integrates SDT/CDT/Gas therapy to boost synergistic ferroptosis for orthotopic hepatocellular carcinoma therapy}, volume = {12}, year = {2025}, }
• (2025). Optimized k+ deposition dynamics via potassiphilic porous interconnected mediators coordinated by single-atom iron for dendrite-free potassium metal batteries. ADVS, 12(8), 2413804. (www)

  @article{ , abstract = {Potassium metal batteries are emerging as a promising high-energy density storage solution, valued for their cost-effectiveness and low electrochemical potential. However, understanding the role of potassiphilic sites in nucleation and growth remains challenging. This study introduces a single-atom iron, coordinated by nitrogen atoms in a 3D hierarchical porous carbon fiber (Fe─N-PCF), which enhances ion and electron transport, improves nucleation and diffusion kinetics, and reduces energy barriers for potassium deposition. Molten potassium infusion experiments confirm the Fe─N-PCF's strong potassiphilic properties, accelerating adsorption kinetics and improving potassium deposition performance. According to the Scharifker-Hills model, traditional carbon fiber substrates without potassiphilic sites cause 3D instantaneous nucleation, leading to dendritic growth. In contrast, the integration of single-atom and hierarchical porosity promotes uniform 3D progressive nucleation, leading to dense metal deposition, as confirmed by dimensionless i 2 /i max 2 versus t/t max plots and real-time in situ optical microscopy. Consequently, in situ X-ray diffraction demonstrated stable potassium cycling for over 1900 h, while the Fe─N-PCF@K||PTCDA full cell retained 69.7% of its capacity after 2000 cycles (72 mAh g −1 ), with a low voltage hysteresis of 0.876 V, confirming its strong potential for high energy density and extended cycle life, paving the way for future advancements in energy storage technology.}, archive = {J_ADVS}, author = {Tzu-Chi Lin and Yi-Chun Yang and Hsing-Yu Tuan}, doi = {10.1002/advs.202413804}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413804}, shortjournal = {Adv. Sci.}, title = {Optimized k+ deposition dynamics via potassiphilic porous interconnected mediators coordinated by single-atom iron for dendrite-free potassium metal batteries}, volume = {12}, year = {2025}, }
• (2025). Engineered MSC-sEVs as a versatile nanoplatform for enhanced osteoarthritis treatment via targeted elimination of senescent chondrocytes and maintenance of cartilage matrix metabolic homeostasis. ADVS, 12(8), 2413759. (www)

  @article{ , abstract = {Chondrocyte senescence is an important pathogenic factor causing osteoarthritis (OA) progression through persistently producing pro-inflammatory factors. Mesenchymal stem cells-derived small extracellular vesicles (MSC-sEVs) have shown anti-inflammatory effects in OA models, while persistent existence of senescent chondrocytes still promotes cartilage destruction. Therefore, improving the targeted elimination ability on senescent chondrocytes is required to facilitate the translation of MSC-sEVs in OA treatment. In this study, versatile engineered MSC-sEVs are developed to targetedly clear senescent chondrocytes and maintain cartilage metabolic homeostasis. Specifically, MSC-sEVs are loaded with siRNA mouse double minute 2 homologue (siMDM2) and modified with cartilage-targeting peptide WYRGRL-PEG 2K -DSPE (WPD), named WPD-sEVs siMDM2 . The results demonstrate versatile modification improves the cellular uptake of MSC-sEVs in chondrocytes, and thus improves the antiaging effects. Importantly, multifunctional modification enhances cartilage penetration ability and extends joint retention time of MSC-sEVs. In both post-traumatic OA mice and naturally aged mice, WPD-sEVs siMDM2 more effectively eliminates senescent chondrocytes and maintained matrix metabolic homeostasis. By using the P53 phosphorylation inhibitor, the essential role MDM2-P53 pathway in the antiaging function of WPD-sEVs siMDM2 on chondrocytes is verified. In ex vivo cultured human OA cartilage explants, it is confirmed that WPD-sEVs siMDM2 alleviates senescent phenotype. Altogether, the findings suggest that WPD-sEVs siMDM2 have promising translational potential for OA treatment.}, archive = {J_ADVS}, author = {Kai Feng and Jiashuo Liu and Liangzhi Gong and Teng Ye and Zhengsheng Chen and Yang Wang and Qing Li and Xuetao Xie}, doi = {10.1002/advs.202413759}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413759}, shortjournal = {Adv. Sci.}, title = {Engineered MSC-sEVs as a versatile nanoplatform for enhanced osteoarthritis treatment via targeted elimination of senescent chondrocytes and maintenance of cartilage matrix metabolic homeostasis}, volume = {12}, year = {2025}, }
• (2025). Interfacial confinement effect of self-adsorbed monolayer enables highly reversible zn metal anodes. ADVS, 12(8), 2413731. (www)

  @article{ , abstract = {The practical applications of aqueous Zn metal batteries are promising, yet still impeded by the corrosion reactions and dendrite growth on the Zn metal anode. Here, a self-adsorbed monolayer (SAM) is designed to stabilize the Zn metal anode. Theory and experiment results show that the interfacial confinement effect of the SAM, for one thing, greatly suppresses the corrosion reactions through the H 2 O-poor inner Helmholtz plane because of the steric-hindrance effect, and for another, alleviates the Zn 2+ concentration gradient on the anode surface through the Zn 2+ enrichment behavior and eventually inhibits the dendrite growth. Consequently, the Zn||Cu cell maintains a Coulombic efficiency of 99.3% at 10 mA cm −2 /1 mAh cm −2 for 2000 cycles, and the Zn||Zn cell can stably cycle for 1400 h at 1 mA cm −2 /1 mAh cm −2 . Additionally, the NVO||Zn pouch cell shows impressive cycling stability (over 200 cycles) and low gassing behavior at 3 A g −1 . This work provides a novel perspective for the interface engineering of Zn metal anodes.}, archive = {J_ADVS}, author = {Yaodong Huo and Shifeng Huang and Zihan Liu and Mengjing Li and Yanjiao Cao and Penghui Tian and Tuotuo Ma and Chenhui Han and Yuliang Gao}, doi = {10.1002/advs.202413731}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413731}, shortjournal = {Adv. Sci.}, title = {Interfacial confinement effect of self-adsorbed monolayer enables highly reversible zn metal anodes}, volume = {12}, year = {2025}, }
• (2025). TRIM21 promotes tumor growth and gemcitabine resistance in pancreatic cancer by inhibiting EPHX1-mediated arachidonic acid metabolism. ADVS, 12(8), 2413674. (www)

  @article{ , abstract = {Pancreatic cancer (PC) progresses rapidly, and gemcitabine-based chemotherapy has brought only limited efficacy. Identifying key drivers and therapeutic targets holds significant clinical value. In this study, through comprehensive analysis of multiple PC databases, this work identifies TRIM21 as a promising driver mediator. This work further performs loss- and gain-of-function assays for TRIM21, revealing that TRIM21 knockout inhibits tumor proliferation and gemcitabine resistance both in vitro and vivo. Lipidomics reveal that silencing TRIM21 reduce the arachidonic acid production, and inhibit ferroptosis. Mechanically, through proteomics, ubiquitomics, and liquid chromatography-tandem mass spectrometry analysis, the key metabolic enzyme of arachidonic acid -EPHX1 is identified as a downstream substrate of TRIM21. TRIM21 interacts with EPHX1 through its SPRY domain and promotes ubiquitin-mediated degradation of EPHX1 via K33- and K48-linked ubiquitination at the K105 site. Given the targeting potential, this work screens Bezafibrate to block the interaction between TRIM21 and EPHX1 and validates its sensitizing effect. In summary, TRIM21 promotes tumour growth and gemcitabine resistance in PC by inhibiting EPHX1-mediated arachidonic acid metabolism. This provides a novel and promising target for clinical treatment of PC.}, archive = {J_ADVS}, author = {Xiaona Fan and Yisheng Dai and Chuanfeng Mo and Hengzhen Li and Xindi Luan and Bojun Wang and Jiani Yang and Guangtao Jiao and XiaoLin Lu and Zhuo Chen and Yuanyu Liao and Ling Qu and Huike Yang and Changjie Lou and Chao Liu and Zhiwei Li}, doi = {10.1002/advs.202413674}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413674}, shortjournal = {Adv. Sci.}, title = {TRIM21 promotes tumor growth and gemcitabine resistance in pancreatic cancer by inhibiting EPHX1-mediated arachidonic acid metabolism}, volume = {12}, year = {2025}, }
• (2025). Bio-inspired catalyst-modified photocathode for bias-free photoelectrochemical NADH regeneration. ADVS, 12(8), 2413668. (www)

  @article{ , abstract = {Cofactors such as nicotinamide adenine dinucleotide (NADH) and its phosphorylated form (NADPH) play a crucial role in natural enzyme-catalyzed reactions for the synthesis of chemicals. However, the stoichiometric supply of NADH for artificial synthetic processes is uneconomical. Here, inspired by the process of cofactor NADPH regeneration in photosystem I (PSI), catalyst-modified photocathodes are constructed on the surface of polythiophene-based semiconductors ( PTTH ) via self-assembly for photoelectrochemical catalytic NADH regeneration. With the assistance of viologen ( vi 2+ ) electron transfer mediators (similar function as Ferredoxin in PSI) linked to the [Rh(Cp * )(bpy)] catalyst, the Rh-vi 2+ @PTTH photocathode exhibits higher photocurrent density (−665 µA cm −2 ) with a high apparent turnover frequency (TOF, 168.4 h −1 ) under a relatively positive potential (0.0 V vs RHE). In addition, through holistic functional mimics of the photosystem, a tandem photoelectrochemical cell is constructed by assembling a CoPi@BiVO 4 photoanode (artificial photosystem II, PSII) with the Rh-vi 2+ @PTTH photocathode. This system achieves a production rate of 42.5 µ m h −1 cm −2 and a TOF of 179.3 h −1 without an externally applied bias for NADH regeneration. The photo-generated NADH is directly employed to assist glutamate dehydrogenase (GDH) in the catalytic conversion of α-ketoglutarate to L-glutamate. This study presents a novel strategic approach for constructing bias-free photoelectrochemical NADH regeneration systems.}, archive = {J_ADVS}, author = {Ziqi Zhao and Yizhou Wu and Chang Liu and Yingzheng Li and Chen Gong and Hongxia Ning and Peili Zhang and Fei Li and Licheng Sun and Fusheng Li}, doi = {10.1002/advs.202413668}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413668}, shortjournal = {Adv. Sci.}, title = {Bio-inspired catalyst-modified photocathode for bias-free photoelectrochemical NADH regeneration}, volume = {12}, year = {2025}, }
• (2025). Hydrogen sulfide promotes TAM-m1 polarization through activating IRE-1α pathway via GRP78 S-sulfhydrylation to against breast cancer. ADVS, 12(8), 2413607. (www)

  @article{ , abstract = {Hydrogen sulfide (H 2 S)-mediated protein S-sulfhydration has been shown to play critical roles in several diseases. Tumor-associated macrophages (TAMs) are the predominant population of immune cells present within solid tumor tissues, and they function to restrict antitumor immunity. However, no previous study has investigated the role of protein S-sulfhydration in TAM reprogramming in breast cancer (BC). Therefore, the aim is to investigate whether protein S-sulfhydration can regulate TAM reprogramming and its underlying mechanism in BC. The results showed that in BC, the CTH-H 2 S axis is positively correlated with the presence of an anti-tumor phenotype in TAMs. NaHS, as an H 2 S donor, repolarized TAMs into M1 macrophages to block the tumor-promoting activities of TAMs both in vitro and in vivo. Mechanistically, H 2 S-mediated S-sulfhydration of the protein chaperone glucose-regulated-protein 78 (GRP78) induced endoplasmic reticulum transmembrane protein kinase-1α (IRE-1α) dissociation from GRP78, which enhanced the phosphatase activity of IRE-1α itself in BC-TAMs, while the Cys420 site mutation of GRP78 interfered with these effects. Collectively, GRP78 S-sulfhydrylation mediated by H 2 S at the Cys420 residue decreased the tumor burden and inhibited lung metastasis of BC through reprograming TAMs via activating the IRE-1α pathway, indicating that targeting GRP78 S-sulfhydration represents a promising intervention for TAM-M1 repolarization in BC.}, archive = {J_ADVS}, author = {Mingyi Ju and Weiwei Tong and Jia Bi and Xianxin Zeng and Aoshuang Qi and Mingli Sun and Jian Wen and Lin Zhao and Minjie Wei}, doi = {10.1002/advs.202413607}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413607}, shortjournal = {Adv. Sci.}, title = {Hydrogen sulfide promotes TAM-m1 polarization through activating IRE-1α pathway via GRP78 S-sulfhydrylation to against breast cancer}, volume = {12}, year = {2025}, }
• (2025). Nitric oxide-releasing nanoscale metal-organic layer overcomes hypoxia and reactive oxygen species diffusion barriers to enhance cancer radiotherapy. ADVS, 12(8), 2413518. (www)

  @article{ , abstract = {Hafnium (Hf)-based nanoscale metal-organic layers (MOLs) enhance radiotherapeutic effects of tissue-penetrating X-rays via a unique radiotherapy-radiodynamic therapy (RT-RDT) process through efficient generation of hydroxy radical (RT) and singlet oxygen (RDT). However, their radiotherapeutic efficacy is limited by hypoxia in deep-seated tumors and short half-lives of reactive oxygen species (ROS). Herein the conjugation of a nitric oxide (NO) donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP), to the Hf 12 secondary building units (SBUs) of Hf-5,5′-di-p-benzoatoporphyrin MOL is reported to afford SNAP/MOL for enhanced cancer radiotherapy. Under X-ray irradiation, SNAP/MOL efficiently generates superoxide anion (O 2 −. ) and releases nitric oxide (NO) in a spatio-temporally synchronized fashion. The released NO rapidly reacts with O 2 −. to form long-lived and highly cytotoxic peroxynitrite which diffuses freely to the cell nucleus and efficiently causes DNA double-strand breaks. Meanwhile, the sustained release of NO from SNAP/MOL in the tumor microenvironment relieves tumor hypoxia to reduce radioresistance of tumor cells. Consequently, SNAP/MOL plus low-dose X-ray irradiation efficiently inhibits tumor growth and reduces metastasis in colorectal and triple-negative breast cancer models.}, archive = {J_ADVS}, author = {Yuxuan Xiong and Jinhong Li and Xiaomin Jiang and Wenyao Zhen and Xin Ma and Wenbin Lin}, doi = {10.1002/advs.202413518}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413518}, shortjournal = {Adv. Sci.}, title = {Nitric oxide-releasing nanoscale metal-organic layer overcomes hypoxia and reactive oxygen species diffusion barriers to enhance cancer radiotherapy}, volume = {12}, year = {2025}, }
• (2025). Ultrasensitive 129Xe magnetic resonance imaging: From clinical monitoring to molecular sensing. ADVS, 12(8), 2413426. (www)

  @article{ , abstract = {Magnetic resonance imaging (MRI) is a cornerstone technology in clinical diagnostics and in vivo research, offering unparalleled visualization capabilities. Despite significant advancements in the past century, traditional 1 H MRI still faces sensitivity limitations that hinder its further development. To overcome this challenge, hyperpolarization methods have been introduced, disrupting the thermal equilibrium of nuclear spins and leading to an increased proportion of hyperpolarized spins, thereby enhancing sensitivity by hundreds to tens of thousands of times. Among these methods, hyperpolarized (HP) 129 Xe MRI, also known as ultrasensitive 129 Xe MRI, stands out for achieving the highest polarization enhancement and has recently received clinical approval. It effectively tackles the challenge of weak MRI signals from low proton density in the lungs. HP 129 Xe MRI is valuable for assessing structural and functional changes in lung physiology during pulmonary disease progression, tracking cells, and detecting target molecules at pico-molar concentrations. This review summarizes recent developments in HP 129 Xe MRI, including its physical principles, manufacturing methods, in vivo characteristics, and diverse applications in biomedical, chemical, and material sciences. In addition, it carefully discusses potential technical improvements and future prospects for enhancing its utility in these fields, further establishing HP 129 Xe MRI's importance in advancing medical imaging and research.}, archive = {J_ADVS}, author = {Yuqi Yang and Sen Yue and Luyang Shen and Huiling Dong and Haidong Li and Xiuchao Zhao and Qianni Guo and Xin Zhou}, doi = {10.1002/advs.202413426}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413426}, shortjournal = {Adv. Sci.}, title = {Ultrasensitive 129Xe magnetic resonance imaging: From clinical monitoring to molecular sensing}, volume = {12}, year = {2025}, }
• (2025). Ferritin-based supramolecular assembly drug delivery system for aminated fullerene derivatives to enhance tumor-targeted therapy. ADVS, 12(8), 2413389. (www)

  @article{ , abstract = {Owing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, their in vivo applications are severely limited due to cation toxicity. To address this problem, human heavy chain ferritin (HFn), possessing natural biocompatibility is utilized, to develop a novel supramolecular assembly drug delivery system. Specifically, tetra[4-(amino)piperidin-1-yl]-C 60 (TAPC) is selected as the representative aminated fullerene, and a layer-by-layer assembly strategy is designed to controllably assemble TAPC with the negatively charged HFn into a hierarchical coassembly (H@T@H) via electrostatic interactions and hydrogen bonds. In this ordered multilayer structure, the surface displayed HFn endows the inner TAPC with biocompatibility, tumor-targeting and blood-brain barrier crossing ability. Additionally, the electrostatic assembly mode enables the acid-responsive disassembly of H@T@H to release TAPC in lysosomes. In the orthotopic glioma mouse model, the HFn-assembled TAPC (H@T@H) shows higher brain accumulation and a stronger inhibitory effect on glioma than polyethylene glycol (PEG)-coated TAPC. Moreover, in an experimental metastasis mouse model, H@T@H have significant preventive and therapeutic effects on tumor metastasis. Encouragingly, the ferritin-based supramolecular assembly strategy has been proven to have broad applicability for various aminated fullerene derivatives, showing promising potential for tackling the in vivo delivery challenges of cationic drugs.}, archive = {J_ADVS}, author = {Baoli Zhang and Libin Yang and Yiliang Jin and Yicheng Lu and Jianru Li and Guoheng Tang and Yang Liu and Jiawei Huo and Ran Xu and Chunru Wang and Xiyun Yan and Jie Li and Kelong Fan}, doi = {10.1002/advs.202413389}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413389}, shortjournal = {Adv. Sci.}, title = {Ferritin-based supramolecular assembly drug delivery system for aminated fullerene derivatives to enhance tumor-targeted therapy}, volume = {12}, year = {2025}, }
• (2025). Specific monitoring the DNA helicase function via anchor-embedded DNA probe. ADVS, 12(8), 2413368. (www)

  @article{ , abstract = {DNA helicases play a pivotal role in maintaining genome integrity by unwinding the DNA double helix and are often considered promising targets for drug development. However, assessing specific DNA helicase activity in living cells remains challenging. Herein, the first anchor-embedded duplex (ATED) probe, 17GC , is constructed to uniquely monitor the unwinding activity of Werner syndrome helicase (WRN), a clinical anticancer target. This probe integrates biophysical screening and molecular simulation approaches. The 17GC probe consists of two components: the first one is a bubble structure as an anchor for recruiting WRN in cells, and the second one is GC-rich double helices on both ends of the bubble, which allow high sensitivity in detecting WRN activity. In vitro evaluations demonstrate that 17GC is highly sensitive and specific to WRN (LOD = 33.5 p m ) compared to a wide range of other enzymes, including helicases and nucleases. Cellular evaluation reveals that the ATED probe exhibits remarkable performance in monitoring WRN helicase activity and assessing the inhibitory efficiency of clinical WRN inhibitors in various cell types. This study introduces a novel approach for designing specific and sensitive probes for DNA helicases in cells, which holds promise for biological characterization and drug development.}, archive = {J_ADVS}, author = {Keni Ning and Xiaoyan Tang and Zhe Li and Liting Zhong and Yingchen Zhou and Jiaen Wang and Wanyi Huang and Han Zhang and Jiajun Ke and Tiangang Luan and Shuo-Bin Chen and Junqiu Zhai}, doi = {10.1002/advs.202413368}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413368}, shortjournal = {Adv. Sci.}, title = {Specific monitoring the DNA helicase function via anchor-embedded DNA probe}, volume = {12}, year = {2025}, }
• (2025). Fracture fusion on fast-forward: Locally administered deferoxamine significantly enhances fracture healing in animal models: A systematic review and meta-analysis. ADVS, 12(8), 2413290. (www)

  @article{ , abstract = {Fractures, with a yearly incidence of 1.2%, can lead to healing complications in up to 10% of cases. The angiogenic stimulant deferoxamine (DFO) is recognized for enhancing bone healing when administered into the fracture gap. This systematic review with meta-analysis investigates the effect of local DFO application on bone healing in rat and mouse models. EMBASE, MEDLINE (PubMed), and Web of Science are systematically searched in January 2024. The study is prospectively registered in PROSPERO (CRD42024492533), and the SYRCLE tool is used to assess study quality and risk of bias. Outcome values contain the primary endpoint bone volume fraction (BV/TV) as well as the secondary endpoints bone volume, tissue volume, bone mineral density, trabecular separation, trabecular thickness, vessel formation and the mechanical properties, assessed by µCT, angiography and mechanical strength tests. Out of 21 included studies, 18 qualify for meta-analysis, involving 539 animals. DFO-treated groups exhibit significantly higher BV/TV values ( p < 0.0001) compared to controls, with similarly significant improvements in secondary outcomes. These findings highlight the substantial benefit of DFO in promoting bone healing, especially after radiotherapy. Rapid clinical implementation is recommended to help patients at high risk of fracture healing complications.}, archive = {J_ADVS}, author = {Daniel Müller and Jens Klotsche and Magdalena B. Kosik and Carsten Perka and Frank Buttgereit and Paula Hoff and Timo Gaber}, doi = {10.1002/advs.202413290}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413290}, shortjournal = {Adv. Sci.}, title = {Fracture fusion on fast-forward: Locally administered deferoxamine significantly enhances fracture healing in animal models: A systematic review and meta-analysis}, volume = {12}, year = {2025}, }
• (2025). A machine vision perspective on droplet-based microfluidics. ADVS, 12(8), 2413146. (www)

  @article{ , abstract = {Microfluidic droplets, with their unique properties and broad applications, are essential in in chemical, biological, and materials synthesis research. Despite the flourishing studies on artificial intelligence-accelerated microfluidics, most research efforts have focused on the upstream design phase of microfluidic systems. Generating user-desired microfluidic droplets still remains laborious, inefficient, and time-consuming. To address the long-standing challenges associated with the accurate and efficient identification, sorting, and analysis of the morphology and generation rate of single and double emulsion droplets, a novel machine vision approach utilizing the deformable detection transformer (DETR) algorithm is proposed. This method enables rapid and precise detection (detection relative error < 4% and precision > 94%) across various scales and scenarios, including real-world and simulated environments. Microfluidic droplets identification and analysis (MDIA), a web-based tool powered by Deformable DETR, which supports transfer learning to enhance accuracy in specific user scenarios is developed. MDIA characterizes droplets by diameter, number, frequency, and other parameters. As more training data are added by other users, MDIA's capability and universality expand, contributing to a comprehensive database for droplet microfluidics. The work highlights the potential of artificial intelligence in advancing microfluidic droplet regulation, fabrication, label-free sorting, and analysis, accelerating biochemical sciences and materials synthesis engineering.}, archive = {J_ADVS}, author = {Ji-Xiang Wang and Hongmei Wang and Huang Lai and Frank X. Liu and Binbin Cui and Wei Yu and Yufeng Mao and Mo Yang and Shuhuai Yao}, doi = {10.1002/advs.202413146}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413146}, shortjournal = {Adv. Sci.}, title = {A machine vision perspective on droplet-based microfluidics}, volume = {12}, year = {2025}, }
• (2025). Hspa13 deficiency impaired marginal zone b cells regulatory function and contributed to lupus pathogenesis. ADVS, 12(8), 2413144. (www)

  @article{ , abstract = {Dysregulated IL-10 producing regulatory B cells (Bregs) are associated with the progression of systemic lupus erythematosus. An immunomodulatory role of heat shock proteins (HSPs) is implicated in autoimmune diseases. However, the molecular basis underlying the role of Hspa13 in regulating Bregs function and lupus pathogenesis remains unclear. In this study, Bregs display higher Hspa13 expression than IL-10 − B cells. Induction of IL-10 production is weakened in B cells with Hspa13 knockdown or knockout. Hspa13 binds to the IL-10 promoter via the TATA or CAAT box and activates IL-10 transcription in the nucleus. Furthermore, Hspa13 positive cells are enriched in marginal zone (MZ) B cells to regulate IL-10 production. Stimulated B220 + B or MZ B cells from CD19 cre Hspa13 fl/fl mice for Breg induction show an impaired capacity to promote CD4 + Foxp3 + regulatory T cells (Treg) differentiation. In lupus MRL/lpr mice, a decline in Treg differentiation is accompanied by decreased Hspa13 expression in both Bregs and MZ B cells. Moreover, adoptive transfusion of Bregs and MZ B cells from CD19 cre Hspa13 fl/fl mice fails to increase the frequency of Tregs, attenuate renal pathology, or decrease anti-dsDNA antibody levels. These results explain the unique role of Hspa13 in determining MZ regulatory function and affecting lupus pathogenesis.}, archive = {J_ADVS}, author = {Chen Xing and Haoran Cui and Ge Li and Xiaoling Liu and Kun Liu and Qing Wen and Xin Huang and Renxi Wang and Lun Song}, doi = {10.1002/advs.202413144}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413144}, shortjournal = {Adv. Sci.}, title = {Hspa13 deficiency impaired marginal zone b cells regulatory function and contributed to lupus pathogenesis}, volume = {12}, year = {2025}, }
• (2025). Advanced morphological and material engineering for high-performance interfacial iontronic pressure sensors. ADVS, 12(8), 2413141. (www)

  @article{ , abstract = {High-performance flexible pressure sensors are crucial for applications such as wearable electronics, interactive systems, and healthcare technologies. Among these, iontronic pressure sensors have garnered particular attention due to their superior sensitivity, enabled by the giant capacitance variation of the electric double layer (EDL) at the ionic-electronic interface under deformation. Key advancements, such as incorporating microstructures into ionic layers and employing diverse materials, have significantly improved sensor properties like sensitivity, accuracy, stability, and response time. This review highlights advancements in flexible EDL pressure sensors, focusing on structural designs and material engineering. These strategies are tailored to optimize key metrics such as sensitivity, detection limit, linearity, stability, response speed, hysteresis, transparency, wearability, selectivity, and multifunctionality. Key fabrication techniques, including micropatterning and externally assisted methods, are reviewed, along with strategies for sensor comparison and guidelines for selecting appropriate sensors. Emerging applications in healthcare, environmental and aerodynamic sensing, human–machine interaction, robotics, and machine learning-assisted intelligent sensing are explored. Finally, this review discusses the challenges and future directions for advancing EDL-based pressure sensors.}, archive = {J_ADVS}, author = {Fengling Zhuo and Zhi Ding and Xi Yang and Fengjian Chu and Yulu Liu and Zhuoqing Gao and Hao Jin and Shurong Dong and Xiaozhi Wang and Jikui Luo}, doi = {10.1002/advs.202413141}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413141}, shortjournal = {Adv. Sci.}, title = {Advanced morphological and material engineering for high-performance interfacial iontronic pressure sensors}, volume = {12}, year = {2025}, }
• (2025). The gut microbiota affects anti-TNF responsiveness by activating the NAD+ salvage pathway in ulcerative colitis. ADVS, 12(8), 2413128. (www)

  @article{ , abstract = {Approximately 50% of the patients with ulcerative colitis (UC) are primarily nonresponsive to anti-tumor necrosis factor (TNF) therapy or lose their responsiveness over time. The gut microbiota plays an important role in the resistance of UC to anti-TNF therapy; however, the underlying mechanism remains unknown. Here, it is found that the transplantation of gut fecal microbiota from patients with UC alters the diversity of the gut microbiota in dextran sulfate sodium-induced colitis mice and may affect the therapeutic responsiveness of mice to infliximab. Furthermore, the abundances of Romboutsia and Fusobacterium increase in the tissues of patients with UC who do not respond to anti-TNF therapy. Differentially abundant metabolites are mainly enriched in nicotinate and nicotinamide metabolism in NCM460 cells after Fusobacterium nucleatum infection. Mechanistically, F. nucleatum promotes the nicotinamide adenine dinucleotide (NAD + ) salvage pathway by upregulating NAMPT expression, which subsequently leads to the activation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway and promotes the secretion of inflammatory factors, ultimately inhibiting the therapeutic response to anti-TNF drugs. These findings demonstrate that the gut microbiota can influence the response to anti-TNF therapy in patients with UC and highlight the therapeutic potential of targeting F. nucleatum and its associated pathways for preventing and treating drug resistance in UC.}, archive = {J_ADVS}, author = {Jing Lei and Lin Lv and Li Zhong and Feng Xu and Wenhao Su and Yan Chen and Zhixuan Wu and Song He and Yongyu Chen}, doi = {10.1002/advs.202413128}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2413128}, shortjournal = {Adv. Sci.}, title = {The gut microbiota affects anti-TNF responsiveness by activating the NAD+ salvage pathway in ulcerative colitis}, volume = {12}, year = {2025}, }
• (2025). A versatile ionic liquid additive for perovskite solar cells: Surface modification, hole transport layer doping, and green solvent processing. ADVS, 12(8), 2412959. (www)

  @article{ , abstract = {Hole-transport layers (HTL) in perovskite solar cells (PSCs) with an n-i-p structure are commonly doped by bis(trifluoromethane)sulfonimide (TFSI) salts to enhance hole conduction. While lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) dopant is a widely used and effective dopant, it has significant limitations, including the need for additional solvents and additives, environmental sensitivity, unintended oxidation, and dopant migration, which can lead to lower stability of PSCs. A novel ionic liquid, 1-(2-methoxyethyl)-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)amide (MMPyTFSI), is explored as an alternative dopant for 2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenylamino)-9,9′-spirobifluorene (spiro-OMeTAD). MMPy ions act as a surface passivator, reducing defects on the perovskite surface, while TFSI ions facilitate p-type doping. MMPyTFSI functions as an efficient dopant, maintaining excellent performance even when tetrahydrofuran (THF) is utilized as a solvent in place of chlorobenzene (CB), while significantly reducing the environmental impact of the process. The optimized PSC achieves a power conversion efficiency (PCE) of 23.10% and demonstrates enhanced long-term stability in all aging tests for over 1000 h in a humid atmosphere, at high temperature, and under simulated sunlight illumination. These results demonstrate that MMPyTFSI is an effective and environmentally friendly dopant for producing stable and efficient PSCs.}, archive = {J_ADVS}, author = {Seong-Jin Jeong and Sung Hwan Park and Siwon Yun and Meng Qiang Li and Dasol Kim and Yongchan Kim and Yun Hee Chang and Jaewon Lee and Jongchul Lim and Tae-Youl Yang}, doi = {10.1002/advs.202412959}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412959}, shortjournal = {Adv. Sci.}, title = {A versatile ionic liquid additive for perovskite solar cells: Surface modification, hole transport layer doping, and green solvent processing}, volume = {12}, year = {2025}, }
• (2025). Tailoring super-performed chemo-sensor via simulation-modeling and MEMS-screening. ADVS, 12(8), 2412937. (www)

  @article{ , abstract = {Chemo-sensor designing involves a time-consuming trial-and-error screening process, which commonly cannot lead to optimal S 4 R features (Sensitivity, Selectivity, Speed, Stability, and Reversibility). Due to strong path dependence on reported groups/mechanisms, conventional chemo-sensors often fail to meet critical application demands, especially in achieving high reversibility without compromising other features. Here, a three-step screen and design strategy is developed for gaining customized chemo-sensors, through Structure modeling; MEMS (Micro Electro Mechanical Systems) analysis, and Performance verification . With such a strategy, the coordination hanging anion mechanism is screened out for reversible nerve agent detection and shows reversible emission enhancement by 25.8 times with DCP, ultrasensitive vapor phase detection (5.7 ppb), and rapid response(10 s) and recovery speed (20 s). Such tailored designing strategy for new organic chemo-sensors will probably play an important role in developing high-performance sensing system in the future.}, archive = {J_ADVS}, author = {Wei Xu and Wukun Zhang and Zhengqi Shen and Wenxing Xu and Jianhao Zhao and Huizi Li and Qingguo He and Yanyan Fu and Jiangong Cheng}, doi = {10.1002/advs.202412937}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412937}, shortjournal = {Adv. Sci.}, title = {Tailoring super-performed chemo-sensor via simulation-modeling and MEMS-screening}, volume = {12}, year = {2025}, }
• (2025). Terahertz-wave polarization space-division multiplexing meta-devices based on spin-decoupled phase control. ADVS, 12(8), 2412688. (www)

  @article{ , abstract = {This study presents a generalized design strategy for novel terahertz-wave polarization space-division multiplexing meta-devices, functioning as multi-polarization generators, modulators, and analyzers. It introduces the spin-decoupled phase control method by combining gradient phase design with circular polarization multiplexing techniques, enabling exceptional flexibility in controlling the polarization directions and spatial distributions of multiple output beams. The meta-device M-4D is significantly demonstrated as proof of concept, which converts an incident linearly polarized wave into four beams with distinct polarization angles. Additionally, the advanced meta-devices M-2B and M-4B are designed to generate two-vector and four-vector Bessel beams with tunable spatial polarization distributions. These meta-devices demonstrate dynamic multi-polarization beam modulation, validated through simulations and experiments. The proposed method significantly expands the design methodology for multi-beam polarization control using all-dielectric metasurfaces and holds promising potential for applications in imaging, sensing, particle manipulation, communication, and information processing. Moreover, it holds potential for adaptation to other spectral ranges.}, archive = {J_ADVS}, author = {Yuehong Xu and Yuma Takida and Tetsu Suzuki and Hiroaki Minamide}, doi = {10.1002/advs.202412688}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412688}, shortjournal = {Adv. Sci.}, title = {Terahertz-wave polarization space-division multiplexing meta-devices based on spin-decoupled phase control}, volume = {12}, year = {2025}, }
• (2025). Lattice oxygen redox dynamics in zeolite-encapsulated CsPbBr3 perovskite OER electrocatalysts. ADVS, 12(8), 2412679. (www)

  @article{ , abstract = {Understanding the oxygen evolution reaction (OER) mechanism is pivotal for improving the overall efficiency of water electrolysis. Despite methylammonium lead halide perovskites (MAPbX 3 ) have shown promising OER performance due to their soft-lattice nature that allows lattice-oxygen oxidation of active α-PbO 2 layer surface, the role of A-site MA or X-site elements in the electrochemical reconstruction and OER mechanisms has yet to be explored. Here, it is demonstrated that the OER mechanism of perovskite@zeolite composites is intrinsically dominated by the A-site group of lead-halide perovskites, while the type of X-site halogen is crucial for the reconstruction kinetics of the composites. Using CsPbBr x I 3- x @AlPO-5 ( x = 0, 1, 2, 3) as a model OER catalyst, it is found that the CsPbBr 3 @AlPO-5 behaves oxygen-intercalation pseudocapacitance during surface restructuring due to absence of halogen-ion migration and phase separation in the CsPbBr 3 , achieving a larger diffusion rate of OH − within the core-shell structure. Moreover, distinct from the single-metal-site mechanism of MAPbBr 3 @AlPO-5, experimental and theoretical investigations reveal that the soft lattice nature of CsPbBr 3 triggers the oxygen-vacancy-site mechanism via the CsPbBr 3 /α-PbO 2 interface, resulting in excellent OER performance. Owing to the variety and easy tailoring of lead-halide perovskite compositions, these findings pave a way for the development of novel perovskite@zeolite type catalysts for efficient oxygen electrocatalysis.}, archive = {J_ADVS}, author = {Xiangrong Ren and Yiyue Zhai and Na Yang and Bolun Wang and Shengzhong (Frank) Liu}, doi = {10.1002/advs.202412679}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412679}, shortjournal = {Adv. Sci.}, title = {Lattice oxygen redox dynamics in zeolite-encapsulated CsPbBr3 perovskite OER electrocatalysts}, volume = {12}, year = {2025}, }
• (2025). Laser upcycling of hemoglobin protein biowaste into engineered graphene aerogel architectures for 3D supercapacitors. ADVS, 12(8), 2412588. (www)

  @article{ , abstract = {Graphene aerogels (GAs) with engineered architectures are a promising material for applications ranging from filtration to energy storage/conversion. However, current preparation approaches involve the combination of multiple intrinsically-different methodologies to achieve graphene-synthesis and architecture-engineering, complicating the entire procedure. Here, a novel approach to prepare GAs with engineered architectures based on the laser-upcycling of protein biowaste, hemoglobin, is introduced. Laser scanning achieves graphene-synthesis concurrently with architecture-engineering through the localized graphitization of hemoglobin along the laser-scan path, enabling the direct preparation of engineered GAs. The laser-upcycled GAs are uniquely decorated with fibrous graphitic structures, which significantly improves the surface area. Such structural formation is attributable to the inherent iron content of hemoglobin which leads to the formation of iron-based nanoparticles that catalyze the formation of nano-structured graphene. By leveraging the high electrical conductivity and unique structural morphology, the laser-upcycled GAs are applied as electrodes of symmetrical 3D supercapacitors. The fabricated supercapacitors exhibited a high specific capacitance (≈54.9 F g −1 ) and excellent cycle stability (≈94% retention), attributable to the laser-engineered architecture facilitating ion diffusion even for thick electrodes. Not only does this study provide a novel approach to prepare GAs with engineered architectures but showcases the potential of laser-upcycling in preparing advanced functional materials for future devices.}, archive = {J_ADVS}, author = {Shuichiro Hayashi and Marco Rupp and Jason X. Liu and Joseph W. Stiles and Ankit Das and Amelia Sanchirico and Samuel Moore and Craig B. Arnold}, doi = {10.1002/advs.202412588}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412588}, shortjournal = {Adv. Sci.}, title = {Laser upcycling of hemoglobin protein biowaste into engineered graphene aerogel architectures for 3D supercapacitors}, volume = {12}, year = {2025}, }
• (2025). Bioactive glycyrrhizic acid ionic liquid self-assembled nanomicelles for enhanced transdermal delivery of anti-photoaging signal peptides. ADVS, 12(8), 2412581. (www)

  @article{ , abstract = {Sigal peptides have garnered remarkable efficacy in rejuvenating photoaged skin and delaying senescence. Nevertheless, their low solubility and poor permeability bring about a formidable challenge in their transdermal delivery. To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) and oxymatrine (OMT) with eminent biocompatibility is first prepared. The components ratios and inherent forming mechanisms of GA-OMT (GAO) are optimized by molecular dynamics simulations and density functional theory calculations. Remarkably, GAO can significantly improve the sparingly soluble properties of palmitoyl pentapeptide-4 (PAL-4), a model peptide drug. Subsequently, GAO self-assembled micelles loading PAL-4 (GAO/PAL-4-SM) are fabricated without additional auxiliary materials. The permeation and subcutaneous retention of PAL-4 are significantly promoted with 10wt.% GAO-SM. Moreover, GAO ILs facilitated PAL-4 permeation by enhancing its miscibility and interaction with stratum corneum (SC), offering a pulling effect and micellar structures for PAL-4, as elucidated by computational simulations. In cellular and animal photoaging experiments, GAO/PAL-4-SM possessed remarkable capabilities in boosting collagen and hyaluronic acid regeneration, mitigating inflammation and apoptosis, accelerating macrophage M2 polarization, thereby lessening skin wrinkles and leveraging elasticity. Collectively, the research innovatively designed an ILs self-assembled nano-micellar transdermal delivery system to enhance the permeability and anti-photoaging effect of signal peptides.}, archive = {J_ADVS}, author = {Zhuxian Wang and Jun Liu and QiuYu Chen and Yufan Wu and Yamei Li and Mingjie Ou and Shuwei Tang and Ziqing Deng and Li Liu and Cuiping Jiang and Hongxia Zhu and Qiang Liu and Bin Yang}, doi = {10.1002/advs.202412581}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412581}, shortjournal = {Adv. Sci.}, title = {Bioactive glycyrrhizic acid ionic liquid self-assembled nanomicelles for enhanced transdermal delivery of anti-photoaging signal peptides}, volume = {12}, year = {2025}, }
• (2025). Single-cell multi-omics assessment of spinal cord injury blocking via cerium-doped upconversion antioxidant nanoenzymes. ADVS, 12(8), 2412526. (www)

  @article{ , abstract = {Spinal cord injury (SCI) impairs the central nervous system and induces the myelin-sheath-deterioration because of reactive oxygen species (ROS), further hindering the recovery of function. Herein, the simultaneously emergency treatment and dynamic luminescence severity assessment (SETLSA) strategy is designed for SCI based on cerium (Ce)-doped upconversion antioxidant nanoenzymes (Ce@UCNP-BCH). Ce@UCNP-BCH can not only efficiently eliminate the SCI localized ROS, but dynamically monitor the oxidative state in the SCI repair process using a ratiometric luminescence signal. Moreover, the classic basso mouse scale score and immunofluorescence analysis together exhibit that Ce@UCNP-BCH effectively facilitates the regeneration of spinal cord including myelin sheath, and promotes the functional recovery of SCI mice. Particularly, the study combines snATAC-eq and snRNA-seq to reveal the heterogeneity of spinal cord tissue following Ce@UCNP-BCH treatment. The findings reveal a significant increase in myelinating oligodendrocytes, as well as higher expression of myelination-related genes, and the study also reveals the gene regulatory dynamics of remyelination after treatment. Besides, the ETLSA strategy synergistically boosts ROS consumption through the superoxide dismutase (SOD)-related pathways after SOD-siRNA treatment. In conclusion, this SETLSA strategy with simultaneously blocking and dynamic monitoring oxidative stress has enriched the toolkit for promoting SCI repair.}, archive = {J_ADVS}, author = {Ke Wang and Judun Zheng and Ronghai Li and Tianjun Chen and Yanming Ma and Ping Wu and Jianxian Luo and Jingyi Zhu and Weiqiang Lin and Minghai Zhao and Yue Yuan and Wen Ma and Xiumei Lin and Yang Wang and Longqi Liu and Peng Gao and Hongsheng Lin and Chuanyu Liu and Yuhui Liao and Zhisheng Ji}, doi = {10.1002/advs.202412526}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412526}, shortjournal = {Adv. Sci.}, title = {Single-cell multi-omics assessment of spinal cord injury blocking via cerium-doped upconversion antioxidant nanoenzymes}, volume = {12}, year = {2025}, }
• (2025). Attractor landscape analysis reveals a reversion switch in the transition of colorectal tumorigenesis. ADVS, 12(8), 2412503. (www)

  @article{ , abstract = {A cell fate change such as tumorigenesis incurs critical transition. It remains a longstanding challenge whether the underlying mechanism can be unraveled and a molecular switch that can reverse such transition is found. Here a systems framework, REVERT, is presented with which can reconstruct the core molecular regulatory network model and a reversion switch based on single-cell transcriptome data over the transition process is identified. The usefulness of REVERT is demonstrated by applying it to single-cell transcriptome of patient-derived matched organoids of colon cancer and normal colon. REVERT is a generic framework that can be applied to investigate various cell fate transition phenomena.}, archive = {J_ADVS}, author = {Dongkwan Shin and Jeong-Ryeol Gong and Seoyoon D. Jeong and Youngwon Cho and Hwang-Phill Kim and Tae-You Kim and Kwang-Hyun Cho}, doi = {10.1002/advs.202412503}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412503}, shortjournal = {Adv. Sci.}, title = {Attractor landscape analysis reveals a reversion switch in the transition of colorectal tumorigenesis}, volume = {12}, year = {2025}, }
• (2025). Cellular Core/Sheath filaments with thermoresponsive vacuum cavities for prolonged passive temperature-adaptive thermoregulation. ADVS, 12(8), 2412448. (www)

  @article{ , abstract = {Acting as the interface between the human body and its environment, clothing is indispensable in human thermoregulation and even survival under extreme environmental conditions. Development of clothing textiles with prolonged passive temperature-adaptive thermoregulation without external energy consumption is much needed for protection from thermal stress and energy saving, but very challenging. Here, a temperature-adaptive thermoregulation filament (TATF) consisting of thermoresponsive vacuum cavities formed by the temperature-responsive volume change of the material confined in the cellular cores of the filament is proposed. Using a droplet-based microfluidic system, the cellular core/sheath filament using octadecane (OD) as a temperature-responsive volume-changing material to form droplet cellular cores within the thermoplastic polyurethane (TPU) sheath is fabricated. It is found that the fabric made of TATF has a remarkable temperature adaptive thermal conductivity, which increases by 83% as the mean fabric temperature increases from 20 °C to 35 °C, due to the volume change of vacuum cavities in the cellular cores of the filament in response to temperature. TATF fabrics have no problem associated with undesirable appearance changes or leakage of encapsulated molten materials as some existing thermoregulatory textiles do, and can therefore have wide applications in functional clothing for prolonged passive personal thermal management.}, archive = {J_ADVS}, author = {Jiayi Sui and Shoukun Jiang and Jinhao Peng and Zhanxiao Kang and Jintu Fan}, doi = {10.1002/advs.202412448}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412448}, shortjournal = {Adv. Sci.}, title = {Cellular Core/Sheath filaments with thermoresponsive vacuum cavities for prolonged passive temperature-adaptive thermoregulation}, volume = {12}, year = {2025}, }
• (2025). Metal-catalyzed abiotic cleavage of C═C bonds for effective fluorescence imaging of Cu(II) and Fe(III) in living systems. ADVS, 12(8), 2412407. (www)

  @article{ , abstract = {Imaging abnormal copper/iron with effective fluorescent tools is essential to comprehensively put insight into many pathological events. However, conventional coordination-based detection is mired in the fluorescence quenching induced by paramagnetic Cu(II)/Fe(III). Moreover, the strong chelating property of the probe will consume dissociative metal ions and inevitably interfere with the physiological microenvironment. Here, a new strategy is developed by employing this aberrant Cu(II)/Fe(III) to catalyze bond cleavage for fluorescent imaging of them. A short series of near-infrared fluorescent molecules ( NIRB1−NIRB6 ) is devised as substrates, wherein the specific C═C bonds can be effectively cleaved to activate red fluorophore by Cu(II)/Fe(III) catalyzing. Representatively, NIRB1 is applied for fluorescent imaging of Cu(II)/Fe(III) in living cells, zebrafish, and Alzheimer's disease (AD)-afflicted mouse brains which is of significance to monitor metal safety. The successful cleavage of C═C bonds catalyzed by Cu(II)/Fe(III) enriches the application of abiotic bond cleavage reactions in metal detection, and may also inspire the development of fluorescent tools for the future diagnosis and therapy of diseases.}, archive = {J_ADVS}, author = {Chunfei Wang and Dandan Chen and Zixiang Wei and Jingyun Tan and Changfeng Wu and Xuanjun Zhang}, doi = {10.1002/advs.202412407}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412407}, shortjournal = {Adv. Sci.}, title = {Metal-catalyzed abiotic cleavage of C═C bonds for effective fluorescence imaging of Cu(II) and Fe(III) in living systems}, volume = {12}, year = {2025}, }
• (2025). Reversible carrier modulation in InP nanolasers by ionic liquid gating with low energy consumption. ADVS, 12(8), 2412340. (www)

  @article{ , abstract = {Nanoscale light sources are demanded vigorously due to rapid development in photonic integrated circuits (PICs). III-V semiconductor nanowire (NW) lasers have manifested themselves as indispensable components in this field, associated with their extremely compact footprint and ultra-high optical gain within the 1D cavity. In this study, the carrier concentrations of indium phosphide (InP) NWs are actively controlled to modify their emissive properties at room temperature. The InP NW lasers can achieve repetitive switching between photoluminescence (PL) and lasing with an extinction ratio of 22-fold by applying a gate voltage of 3 V using ionic liquid (IL) as a dielectric layer. IL brings forth ultra-high capacitance due to the nanometer-wide electric double layer (EDL) between interfaces, mapping out gating efficiency of ≈100-fold compared to the conventional bottom gate configurations. This IL-embedded nanolaser device can be a promising platform for the advanced integrated nanophotonic system.}, archive = {J_ADVS}, author = {Chia-Hung Wu and Chi-Wen Chen and Hung-Jung Shen and Hsiang-Yu Chuang and Hark Hoe Tan and Chennupati Jagadish and Tien-Chang Lu and Satoshi Ishii and Kuo-Ping Chen}, doi = {10.1002/advs.202412340}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412340}, shortjournal = {Adv. Sci.}, title = {Reversible carrier modulation in InP nanolasers by ionic liquid gating with low energy consumption}, volume = {12}, year = {2025}, }
• (2025). Comparing large language models and human programmers for generating programming code. ADVS, 12(8), 2412279. (www)

  @article{ , abstract = {The performance of seven large language models (LLMs) in generating programming code using various prompt strategies, programming languages, and task difficulties is systematically evaluated. GPT-4 substantially outperforms other LLMs, including Gemini Ultra and Claude 2. The coding performance of GPT-4 varies considerably with different prompt strategies. In most LeetCode and GeeksforGeeks coding contests evaluated in this study, GPT-4, employing the optimal prompt strategy, outperforms 85 percent of human participants in a competitive environment, many of whom are students and professionals with moderate programming experience. GPT-4 demonstrates strong capabilities in translating code between different programming languages and in learning from past errors. The computational efficiency of the code generated by GPT-4 is comparable to that of human programmers. GPT-4 is also capable of handling broader programming tasks, including front-end design and database operations. These results suggest that GPT-4 has the potential to serve as a reliable assistant in programming code generation and software development. A programming assistant is designed based on an optimal prompt strategy to facilitate the practical use of LLMs for programming.}, archive = {J_ADVS}, author = {Wenpin Hou and Zhicheng Ji}, doi = {10.1002/advs.202412279}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412279}, shortjournal = {Adv. Sci.}, title = {Comparing large language models and human programmers for generating programming code}, volume = {12}, year = {2025}, }
• (2025). Low-cost intrinsic flame-retardant bio-based high performance polyurethane and its application in triboelectric nanogenerators. ADVS, 12(8), 2412258. (www)

  @article{ , abstract = {Flammability is a significant challenge in polymer-based electronics. In this regard, triboelectric nanogenerators (TENGs) have enabled a safe means for harvesting mechanical energy for conversion into electrical energy. However, most existing polymers used for TENGs are sourced from petroleum-based raw materials and are highly flammable, which can further accelerate the spread of fire and harm the ecological environment. In addition, the existing intrinsic flame-retardant TENGs are not elastic at room temperature, which may potentially damage the flexible equipment and harm firefighters. This study presents an intrinsic flame-retardant bio-based elastic phytic acid polyurethane (PUPA) synthesized using a simple and efficient one-pot polycondensation. The cross-linked structure and polar phosphorus-containing segments of PUPA are fabricated into PUPA-TENG, demonstrating a superior elasticity (elongation up to 660%), flame retardancy (UL94 V-0), impact resistance (34.71 MJ m −3 ), and dielectric constant ( D k = 9.57). Consequently, this study provides a simple strategy for tailoring TENGs toward environmentally friendly and secure power generators and electronics, which can effectively reduce fire hazards and potentially be applied to other fire-risk fields such as personal protection, firefighting, and new energy.}, archive = {J_ADVS}, author = {Xiaoyu Zhang and Xixian Yan and Fanglei Zeng and Hao Zhang and Peiyao Li and Haiyang Zhang and Ning Li and Qingbao Guan and Zhengwei You}, doi = {10.1002/advs.202412258}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412258}, shortjournal = {Adv. Sci.}, title = {Low-cost intrinsic flame-retardant bio-based high performance polyurethane and its application in triboelectric nanogenerators}, volume = {12}, year = {2025}, }
• (2025). Combined blockade of lipid uptake and synthesis by CD36 inhibitor and SCD1 siRNA is beneficial for the treatment of refractory prostate cancer. ADVS, 12(8), 2412244. (www)

  @article{ , abstract = {Drug resistance is an important factor for prostate cancer (PCa) to progress into refractory PCa, and abnormal lipid metabolism usually occurs in refractory PCa, which presents great challenges for PCa therapy. Here, a cluster of differentiation 36 (CD36) inhibitor sulfosuccinimidyl oleate sodium (CD36i) and stearoyl-CoA desaturase 1 (SCD1) siRNA (siSCD1) are selected to inhibit lipid uptake and synthesis in PCa, respectively. To this end, a multiresponsive drug delivery nanosystem, HA@CD36i-TR@siSCD1 is designed. The hyaluronic acid (HA) gel “shell” of HA-TR nanosystem can release drugs in response to the acidic tumor microenvironment and hyaluronidase, and the tumor targeting (TR) cationic micellar “core” can release drugs in response to glutathione. This multiresponsive drug release is beneficial for the exogenous inhibition of lipid uptake by CD36i and the endogenous inhibition of lipid synthesis by siSCD1. The established HA-TR nanosystem has good tumor targeting ability and tumor penetration ability, and that HA@CD36i-TR@siSCD1 has good synergistic effects, which can significantly restrain the growth, invasion, and metastasis of PCa. Moreover, under high-fat conditions, the tumors are more sensitive to HA@CD36i-TR@siSCD1 treatment, almost no accumulation of lipid droplets is observed in HA@CD36i-TR@siSCD1-treated tumors, with enhanced antitumor immunity. Hence, this study provides a new treatment option for refractory PCa patients, especially those with a high-fat diet.}, archive = {J_ADVS}, author = {Jiyuan Chen and Xiaoyan Yu and Gang Yang and Xueying Chen and Chunai Gong and Lu Han and Yujie Wang and Rong Wang and Lei Wang and Yongfang Yuan}, doi = {10.1002/advs.202412244}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412244}, shortjournal = {Adv. Sci.}, title = {Combined blockade of lipid uptake and synthesis by CD36 inhibitor and SCD1 siRNA is beneficial for the treatment of refractory prostate cancer}, volume = {12}, year = {2025}, }
• (2025). Construction of full-spectrum-response Bi3O4Br: Er3+@Bi2O3-x S-scheme heterojunction with [Bi─O] tetrahedral sharing by integrated upconversion and photothermal effect toward optimized photocatalytic performance. ADVS, 12(8), 2412214. (www)

  @article{ , abstract = {Designing and optimizing photocatalysts to maximize the use of sunlight and achieve fast charge transport remains a goal of photocatalysis technology. Herein, a full-spectrum-response Bi 3 O 4 Br:Er 3+ @Bi 2 O 3- x core–shell S-scheme heterojunction is designed with [Bi─O] tetrahedral sharing using upconversion (UC) functionality, photothermal effects, and interfacial engineering. The UC function of Er 3+ and plasmon resonance effect of Bi 2 O 3- x greatly improves the utilization of sunlight. The equivalent layer structure of Bi 3 O 4 Br and Bi 2 O 3- x facilitates the construction of high-quality S-scheme heterojunction interfaces with close atomic-level contact obtained from the [Bi─O] tetrahedral sharing and the resulting Bi 3 O 4 Br:Er 3+ @Bi 2 O 3- x core–shell morphology, enabled efficient charge transfer. Furthermore, localized temperature increase, induced by photothermal effects, enhanced the chemical reaction kinetics. Benefiting from the distinctive construction, the Bi 3 O 4 Br:Er 3+ @Bi 2 O 3- x heterojunctions exhibit excellent performance in the photocatalytic degradation of bisphenol A that is 2.40 times and 4.98 times greater than that of Bi 3 O 4 Br:Er 3+ alone under full-spectrum light irradiation and near-infrared light irradiation, respectively. This work offers an innovative perspective for the design and fabrication of full-spectrum-response S-scheme heterojunction photocatalysts with efficient solar energy utilization based on high quality interfaces, UC functionality, and the photothermal effect.}, archive = {J_ADVS}, author = {Zhifeng Li and Liang Xu and Zhaoyi Yin and Junhao Ma and Xiaoyi Dong and Shangyong Wang and Zhiguo Song and Jianbei Qiu and Yongjin Li}, doi = {10.1002/advs.202412214}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2412214}, shortjournal = {Adv. Sci.}, title = {Construction of full-spectrum-response Bi3O4Br: Er3+@Bi2O3-x S-scheme heterojunction with [Bi─O] tetrahedral sharing by integrated upconversion and photothermal effect toward optimized photocatalytic performance}, volume = {12}, year = {2025}, }
• (2025). Rare-earth substitution induced symmetry breaking for the first sc-based nonlinear optical chalcogenide with high-performance. ADVS, 12(8), 2411960. (www)

  @article{ , abstract = {Chalcogenides are the most important infrared nonlinear optical (NLO) material candidates, and the exploration of high-performance ones is attractive and challengeable. Hitherto, there is no NLO scandium (Sc) chalcogenides experimentally studied. Here, new quaternary Sc thiophosphate CsScP 2 S 7 (CSPS) was synthesized by the facile metal oxide-boron-sulfur/reactive flux hybrid solid-state method. It crystallizes in the monoclinic chiral space group C 2, and the layered structure is composed by the new ScP 2 S 11 functional motifs built by ScS 6 octahedra and P 2 S 7 dimers, and the structure-performance analysis reveals that the hyperpolarizability of ScP 2 S 11 is much greater than the assembled units (ScS 6 and PS 4 ), which makes the first NLO Sc chalcogenide CSPS exhibits strong NLO response (0.8 × AGS) and high laser-induced damage threshold (LIDT) (4.3 × AGS), and a wide bandgap of 3.10 eV. With the coordination number's reduction of rare-earth (RE) ion and the rearrangement of P 2 S 7 dimers, the centrosymmetric structure of CsREP 2 S 7 family can be broken via substitution with the smallest RE element Sc to form the noncentrosymmetric structure. This work not only discovers a new high-performance infrared NLO material, but also will inspire researchers to explore more potential NLO Sc chalcogenides.}, archive = {J_ADVS}, author = {Chen-Yi Zhao and Chun-Li Hu and Nian-Tzu Suen and Xiao-Hui Li and Hai-Ping Xu and Wenfeng Zhou and Sheng-Ping Guo}, doi = {10.1002/advs.202411960}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411960}, shortjournal = {Adv. Sci.}, title = {Rare-earth substitution induced symmetry breaking for the first sc-based nonlinear optical chalcogenide with high-performance}, volume = {12}, year = {2025}, }
• (2025). Aldehyde dehydrogenase 2 lactylation aggravates mitochondrial dysfunction by disrupting PHB2 mediated mitophagy in acute kidney injury. ADVS, 12(8), 2411943. (www)

  @article{ , abstract = {Mitochondrial dysfunction is a crucial event in acute kidney injury (AKI), leading to a metabolic shift toward glycolysis and increased lactate production. Lactylation, a posttranslational modification derived from lactate, plays a significant role in various cellular processes, yet its implications in AKI remain underexplored. Here, a marked increase in lactate levels and pan-Kla levels are observed in kidney tissue from AKI patients and mice, with pronounced lactylation activity in injured proximal tubular cells identified by single-cell RNA sequencing. The lactylation of aldehyde dehydrogenase 2 (ALDH2) is identified at lysine 52 (K52la), revealing that ALDH2 lactylation exacerbates tubular injury and mitochondrial dysfunction. Conversely, the ALDH2 K52R mutation alleviates these injuries in HK-2 cells and adeno-associated virus-infected kidney tissues in mice. Furthermore, ALDH2 lactylation can be modulated by upregulating SIRT3 in vivo and in vitro, which reduces ALDH2 lactylation, mitigating tubular injury and mitochondrial dysfunction. Mechanistically, immunoprecipitation-mass spectrometry analysis demonstrates an interaction between ALDH2 and prohibitin 2 (PHB2), a crucial mitophagy receptor. ALDH2 lactylation promotes the ubiquitination-proteasomal degradation of PHB2 to inhibit mitophagy and worsen mitochondrial dysfunction. These findings highlight the critical role of endogenous lactate in AKI and propose ALDH2 lactylation as a potential therapeutic target.}, archive = {J_ADVS}, author = {Jiaying Li and Xiaoxiao Shi and Jiatong Xu and Kaiyue Wang and Fangxing Hou and Xiaodong Luan and Limeng Chen}, doi = {10.1002/advs.202411943}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411943}, shortjournal = {Adv. Sci.}, title = {Aldehyde dehydrogenase 2 lactylation aggravates mitochondrial dysfunction by disrupting PHB2 mediated mitophagy in acute kidney injury}, volume = {12}, year = {2025}, }
• (2025). Weighted echo state graph neural networks based on robust and epitaxial film memristors. ADVS, 12(8), 2411925. (www)

  @article{ , abstract = {Hardware system customized toward the demands of graph neural network learning would promote efficiency and strong temporal processing for graph-structured data. However, most amorphous/polycrystalline oxides-based memristors commonly have unstable conductance regulation due to random growth of conductive filaments. And graph neural networks based on robust and epitaxial film memristors can especially improve energy efficiency due to their high endurance and ultra-low power consumption. Here, robust and epitaxial Gd: HfO2-based film memristors are reported and construct a weighted echo state graph neural network (WESGNN). Benefiting from the optimized epitaxial films, the high switching speed (20 ns), low energy consumption (2.07 fJ), multi-value storage (4 bits), and high endurance (10 9 ) outperform most memristors. Notably, thanks to the appropriately dispersed conductance distribution (standard deviation = 7.68 nS), the WESGNN finely regulates the relative weights of input nodes and recursive matrix to realize state-of-the-art performance using the MUTAG and COLLAB datasets for graph classification tasks. Overall, robust and epitaxial film memristors offer nanoscale scalability, high reliability, and low energy consumption, making them energy-efficient hardware solutions for graph learning applications.}, archive = {J_ADVS}, author = {Zhenqiang Guo and Guojun Duan and Yinxing Zhang and Yong Sun and Weifeng Zhang and Xiaohan Li and Haowan Shi and Pengfei Li and Zhen Zhao and Jikang Xu and Biao Yang and Yousef Faraj and Xiaobing Yan}, doi = {10.1002/advs.202411925}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411925}, shortjournal = {Adv. Sci.}, title = {Weighted echo state graph neural networks based on robust and epitaxial film memristors}, volume = {12}, year = {2025}, }
• (2025). Multifaceted immunomodulatory nanocomplexes target neutrophilic-ROS inflammation in acute lung injury. ADVS, 12(8), 2411823. (www)

  @article{ , abstract = {The sepsis-induced acute lung injury (ALI) still represents one of the leading causes of death in critically ill patients, underscoring the need for novel therapies. Excessive activation of immune cells and damage of reactive oxygen species (ROS) are the main factors that exacerbate lung injury. Here, the multifaceted immunomodulatory nanocomplexes targeting the proinflammatory neutrophilic activation and ROS damage are established. The S100A8/9 inhibitor, ABR2575, is loaded in the nanocomplexes, which effectively blocks the neutrophils-S100A8/A9- toll-like receptors (TLRS)-Inflammasome signaling in ALI. Synergically, the SiH nanosheets are encapsulated together with ABR2575 into the core of poly(lactic- co -glycolic acid) (PLGA) nanosponges, to achieve sustainable hydrogen release for the alleviation of ROS-induced lung tissue injury, and also promote the M2 polarization of macrophages. This novel combination strategy is proven to significantly suppress the infiltration of neutrophils and pro-inflammatory macrophages into the lungs, decrease the activation of neutrophils and pro-inflammatory monocytes in the blood, facilitate the anti-inflammatory polarization of macrophages and monocytes, and reduce the expression of pro-inflammatory cytokines in both the lung and blood circulation, all of which alleviate the lung injuries in preclinical murine ALI models. The current investigations offer a novel nanomedicine for the treatment of ALI with great potential in clinical invention.}, archive = {J_ADVS}, author = {Fan Su and Chong Zhang and Qianyun Zhang and Yi Shen and Saiqi Li and Jianlin Shi and Ya-Xuan Zhu and Han Lin and Bin He}, doi = {10.1002/advs.202411823}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411823}, shortjournal = {Adv. Sci.}, title = {Multifaceted immunomodulatory nanocomplexes target neutrophilic-ROS inflammation in acute lung injury}, volume = {12}, year = {2025}, }
• (2025). Toward green liquid nitrogen fertilizer synthesis: Plasma-driven nitrogen oxidation and partial electrocatalytic reduction. ADVS, 12(8), 2411783. (www)

  @article{ , abstract = {Liquid fertilizers, particularly when integrated with precision irrigation systems, offer a more efficient and sustainable alternative to traditional solid nitrogen fertilizers. The industrial production of ammonium nitrate (NH 4 NO 3 ) is environmentally detrimental due to its reliance on fossil fuels. This study introduces an innovative air-to-NOx-to-NH 4 NO 3 pathway for synthesizing liquid nitrogen fertilizer. The process employs an underwater multi-bubble plasma reactor powered by nanosecond pulse to generate aqueous NOx, which is then partially reduced to NH 4 NO 3 through electrocatalysis. Results show that the highest NOx production rate, 786.5 mol h −1 , is achieved when the N 2 /O 2 ratio closely resemble that of air, and short pulse rise/fall times significantly increase NOx yield. Further plasma diagnostic and global plasma chemistry modeling indicate that short rise/fall times facilitate simultaneous dielectric barrier discharge and spark discharge, synergistically enhancing nitrogen fixation efficiency. The partially electro-reduced liquid NH 4 NO 3 fertilizer significantly improves plant growth, with stem length and leaf length increasing by 91.26% and 54.72%, respectively. Cost estimation reveals that 44.22% of the production cost is attributed to electricity consumption, underscoring the potential for optimization with renewable energy integration. Overall, the study provides new insight for the sustainable production and in-place utilization of liquid nitrogen fertilizers which may advance sustainable agriculture.}, archive = {J_ADVS}, author = {Zhongping Qu and Jungmi Hong and Yuting Gao and Jing Sun and Jingwen Huang and Mingyan Zhang and Mengying Zhu and Tianyu Li and Xiangyu Wang and Dingwei Gan and Qiang Song and Tianqi Zhang and Rusen Zhou and Dingxin Liu and Patrick J. Cullen and Renwu Zhou}, doi = {10.1002/advs.202411783}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411783}, shortjournal = {Adv. Sci.}, title = {Toward green liquid nitrogen fertilizer synthesis: Plasma-driven nitrogen oxidation and partial electrocatalytic reduction}, volume = {12}, year = {2025}, }
• (2025). Posttranscriptional control of neural progenitors temporal dynamics during neocortical development by syncrip. ADVS, 12(8), 2411732. (www)

  @article{ , abstract = {The development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons, remain unclear. Here, the hnRNP family member Syncrip (hnRNP Q) is identified as a key modulator of superficial neuronal differentiation in neocortical neurogenesis. Syncrip knockout in RGCs disrupts differentiation and abnormal neuronal localization, ultimately resulting in superficial cortical layer defects as well as learning and memory impairments in mice. Single-cell RNA sequencing analysis demonstrated that the knockout of Syncrip disrupts the late-stage neurogenesis, stalling transcriptional progression in RGCs. Mechanistically, Syncrip maintains the transcription of temporal process-related transcription factors by recruiting stabilization complexes through phase separation, crucially regulating the Notch signaling pathway that determines the fate of RGCs. Furthermore, pathogenic human mutations in Syncrip weaken its phase-separation capability, failing to form stable complexes normally. Thus, Syncrip acts as a mediator of posttranscriptional regulatory mechanisms, governing the fate progression of RGCs and the advancement of intrinsic temporal programs. This study establishes an intracellular mechanism for posttranscriptional regulation of progressive fate determination in cortical neurogenesis.}, archive = {J_ADVS}, author = {Jiarui Wu and Haoyang Yu and Xinyi Dou and Bin Yin and Lin Hou and Yuanchao Xue and Boqin Qiang and Pengcheng Shu and Xiaozhong Peng}, doi = {10.1002/advs.202411732}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411732}, shortjournal = {Adv. Sci.}, title = {Posttranscriptional control of neural progenitors temporal dynamics during neocortical development by syncrip}, volume = {12}, year = {2025}, }
• (2025). Myeloid-derived suppressor cell accumulation drives intestinal fibrosis through mCCL6/hCCL15 chemokine-mediated fibroblast activation. ADVS, 12(8), 2411711. (www)

  @article{ , abstract = {Intestinal fibrosis, a severe complication of Crohn's disease (CD), is linked to chronic inflammation, but the precise mechanism by which immune-driven intestinal inflammation leads to fibrosis development is not fully understood. This study investigates the role of myeloid-derived suppressor cells (MDSCs) in intestinal fibrosis in CD patients and a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced mouse model. Elevated MDSCs are observed in inflamed intestinal tissues prior to fibrosis and their sustained presence in fibrotic tissues of both CD patients and murine models. Depletion of MDSCs significantly reduces fibrosis, highlighting their key role in the fibrotic process. Mechanistically, MDSC-derived mCCL6 activates fibroblasts via the CCR1-MAPK signaling, and interventions targeting this axis, including neutralizing antibodies, a CCR1 antagonist, or fibroblast-specific Ccr1 knockout mice reduce fibrosis. In CD patients with stenosis, human CCL15, analogous to mCCL6, is found to be elevated in MDSCs and activated fibroblasts. Additionally, CXCR2 and CCR2 ligands are identified as key mediators of MDSC recruitment in intestinal fibrosis. Blocking MDSC recruitment with CXCR2 and CCR2 antagonists alleviates intestinal fibrosis. These findings suggest that strategies targeting MDSC recruitment and mCCL6/hCCL15 signaling could offer therapeutic benefits for intestinal fibrosis.}, archive = {J_ADVS}, author = {Xiaohui Cheng and Pingwen Shao and XinTong Wang and Juan Jiang and Jiahui Chen and Jie Zhu and Weiming Zhu and Yi Li and Junfeng Zhang and Jiangning Chen and Zhen Huang}, doi = {10.1002/advs.202411711}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411711}, shortjournal = {Adv. Sci.}, title = {Myeloid-derived suppressor cell accumulation drives intestinal fibrosis through mCCL6/hCCL15 chemokine-mediated fibroblast activation}, volume = {12}, year = {2025}, }
• (2025). Patterning the pore orientation of nanoporous metal via self-organization in flow cells. ADVS, 12(8), 2411695. (www)

  @article{ , abstract = {Nanoporous metals, a class of free-standing, high specific-area materials, evolve from interface-controlled self-organization in a selective dissolution (e.g., dealloying). The process creates randomly oriented pores, in which slow mass transport has limited the functional applications of nanoporous metals. Here the control of the pore orientation is demonstrated with a dealloying analogy, reduction-induced decomposition, achieved in flow cells. Via forced convection, the self-organization is placed under the control of sufficiently rapid mass transport to suppress pore branching and align 100 nm-wide ligaments and pores along the direction of reaction propagation, boosting the permeability by an order of magnitude while retaining the large surface area. The pore orientation can be further manipulated with a flow field for an orientation pattern akin to the expected fluid pattern, enabling a nanoporous silver electrode to deliver a peak power of 0.3 W cm −2 in a redox-flow battery, outperforming commercial carbon electrodes.}, archive = {J_ADVS}, author = {Congcheng Wang and Yang Li and Xiangwei Geng and Jiatao Mao and Qing Chen}, doi = {10.1002/advs.202411695}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411695}, shortjournal = {Adv. Sci.}, title = {Patterning the pore orientation of nanoporous metal via self-organization in flow cells}, volume = {12}, year = {2025}, }
• (2025). Wearable fluidic fabric with excellent heat transfer performance for sports recovery. ADVS, 12(8), 2411691. (www)

  @article{ , abstract = {Rapid temperature contrast hydrotherapy by water immersion has been utilized by athletes for effective sports recovery. However, its application at some training or competition venues is limited by high water consumption, bucky size, personal hygiene, and inconvenience. Here, a novel portable system equipped with highly effective, lightweight, and hygienic wearable fluidic fabric device is reported, that replaces direct water immersion. The measured heat transfer coefficient between the skin and the fabric is 98.5 W m −2 K −1 , which is 92% of that in direct water immersion at 10 °C and significantly higher than that by previously reported cooling garments. The core layer, a flexible heat transfer panel (FHTP), can switch between cold and hot modes (5–40 °C) over an area of 0.3 m 2 . The contact condition between skin and the deformable FHTP has been considered in a new verified heat transfer model. Optimization of the parameters has resulted in excellent heat transfer performance. This fluidic fabric also holds potential in diverse applications, such as enhancing thermal safety and comfort in extreme environments (e.g., personal thermal management systems and fire-protection suits), supporting cryotherapy and thermotherapy in rehabilitation and healthcare, and simulation of total tactile sensations in virtual reality.}, archive = {J_ADVS}, author = {Jing Yang and Ying Xiong and Jinli Piao and Manyui Leung and Guosai Liu and Mingyue Zhu and Shengyang Tang and Lisha Zhang and Xiaoming Tao}, doi = {10.1002/advs.202411691}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411691}, shortjournal = {Adv. Sci.}, title = {Wearable fluidic fabric with excellent heat transfer performance for sports recovery}, volume = {12}, year = {2025}, }
• (2025). Primary cilia formation mediated by Hsa_Circ_0005185/OTUB1/RAB8A complex inhibits prostate cancer progression by suppressing hedgehog signaling pathway. ADVS, 12(8), 2411675. (www)

  @article{ , abstract = {Prostate cancer (PCa) is one of the most common malignancies for male individuals globally. Androgen deprivation therapy (ADT) initially demonstrated significant efficacy in treating PCa; however, most cases of PCa eventually progress to castration-resistant prostate cancer (CRPC), which becomes increasingly challenging to manage. Notably, the loss or disruption of primary cilia in PCa cells may play a critical role in the progression of the disease, and there are no reports on the role of circular RNAs in ciliogenesis. Thus, this warrants further investigation.In this study, key circular RNAs linked to prostate cancer progression, and enzalutamide resistance is identified. Specifically, it is found that hsa_circ_0005185 interacts with OTUB1 and RAB8A, serving as a molecular scaffold. Hsa_circ_0005185 mediates the binding of the deubiquitinase OTUB1 to RAB8A, resulting in the deubiquitination of RAB8A. Consequently, the stable expression of RAB8A promotes the regeneration of primary cilia and enhances the production of GLI3R, an inhibitory factor in the Hedgehog signaling pathway, thereby suppressing AR activity and slowing the progression of CRPC.}, archive = {J_ADVS}, author = {Aoyu Fan and Yunyan Zhang and Yunpeng Li and Wei Meng and Fan Wu and Wei Pan and Zhongliang Ma and Wei Chen}, doi = {10.1002/advs.202411675}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411675}, shortjournal = {Adv. Sci.}, title = {Primary cilia formation mediated by Hsa_Circ_0005185/OTUB1/RAB8A complex inhibits prostate cancer progression by suppressing hedgehog signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Chirality-induced hydroxyapatite manipulates enantioselective bone-implant interactions toward ameliorative osteoporotic osseointegration. ADVS, 12(8), 2411602. (www)

  @article{ , abstract = {Inspired by the fundamental attribute of chirality in nature, chiral-engineered biomaterials now represent a groundbreaking frontier in biomedical fields. However, the integration of chirality within inorganic materials remains a critical challenge and developments of chirality-induced bionic bone implants are still in infancy. In this view, novel chiral hydroxyapatite (CHA) coated Ti alloys are successfully synthesized by a sophisticated chiral molecule-induced self-assembly method for the first time. The obtained samples are characterized by stereospecific L-/D-/Rac-chiral hierarchical morphology, nanotopography rough surfaces, improved hydrophilicity, and bioactivity. Following implantation into rat femoral condyle defects, the distinct stereospecific chiral hierarchical structures exhibit highly enantioselective bone-implants interactions, wherein the left-handed chirality of L-CHA strongly promotes osteoporotic osseointegration and vice versa for right-handed chirality of D-CHA. Consistently, in vitro assays further validate the superior enantiomer-dependent osteoporotic osseointegration ability of L-CHA, mainly by manipulating desired immunomodulation coupled with enhanced neurogenesis, angiogenesis, and osteogenesis. Moreover, as analyzed by transcriptomic RNA-seq, a new discovery of down-regulated IL-17 signaling pathway is considered predominately responsible for the desired immunomodulation ability of L-CHA. These results provide new insights into biological multifunctionality and mechanism underlying L-chirality's roles for bone healing, thus may inspiring developments of new generation of chiral biomaterials.}, archive = {J_ADVS}, author = {Liang Yang and Jinzhou Du and Shengyang Jin and Shuyi Yang and Zhaowei Chen and Shiyang Yu and Cunyi Fan and Chao Zhou and Hongjiang Ruan}, doi = {10.1002/advs.202411602}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411602}, shortjournal = {Adv. Sci.}, title = {Chirality-induced hydroxyapatite manipulates enantioselective bone-implant interactions toward ameliorative osteoporotic osseointegration}, volume = {12}, year = {2025}, }
• (2025). Enhanced genome editing activity with novel chimeric ScCas9 variants in rice. ADVS, 12(8), 2411549. (www)

  @article{ , abstract = {The Streptococcus canis Cas9 protein (ScCas9) recognizes the NNG protospacer adjacent motif (PAM), offering a wider range of targets than that offered by the commonly used S. pyogenes Cas9 protein (SpCas9). However, both ScCas9 and its evolved Sc++ variant still exhibit low genome editing efficiency in plants, particularly at the less preferred NTG and NCG PAM targets. In this study, a chimeric SpcRN++ variant is engineered by grafting the recognition (REC) domain of SpCas9 into the Sc++ variant, incorporating the R221K/N394K mutations, and retaining the positively charged loop of S. anginosus Cas9. The SpcRN++ variant exhibits a higher genome editing capacity and wider target range than the Sc++ variant in rice protoplasts and stable transgenic plants. Further evidence indicates that nSpcRN++-based A3A/Y130F and TadA8e exhibit enhanced cytosine and adenine editing efficiency in plants. Finally, herbicide-resistant rice germplasms are produced by targeting the OsACC gene using nSpcRN++-based adenine base editors. These results demonstrate that SpcRN++ is a powerful tool for genome editing in plants, and this integrative protein engineering strategy holds promise for engineering other Cas9 proteins.}, archive = {J_ADVS}, author = {Zhen Liang and Yuqing Wu and Shuke Deng and Sha Wei and Kai Zhang and Yingjie Guo}, doi = {10.1002/advs.202411549}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411549}, shortjournal = {Adv. Sci.}, title = {Enhanced genome editing activity with novel chimeric ScCas9 variants in rice}, volume = {12}, year = {2025}, }
• (2025). Gut commensal barnesiella intestinihominis ameliorates hyperglycemia and liver metabolic disorders. ADVS, 12(8), 2411181. (www)

  @article{ , abstract = {Recent studies have highlighted the role of the gut microbiota in type 2 diabetes (T2D). Improving gut microbiota dysbiosis can be a potential strategy for the prevention and management of T2D. Here, this work finds that the abundance of Barnesiella intestinihominis is significantly decreased in the fecal of T2D patients from 2-independent centers. Oral treatment of live B. intestinihominis (LBI) considerably ameliorates hyperglycemia and liver metabolic disorders in HFD/STZ-induced T2D models and db/db mice. LBI-derived acetate has similar protective effects against T2D. Mechanistically, acetate enhances fibroblast growth factor 21 (FGF21) through inhibition of histone deacetylase 9 (HDAC9) to increase H3K27 acetylation at the FGF21 promoter. The screening puerarin from Gegen Qinlian decoction in a gut microbiota-dependent manner improved hyperglycemia and liver metabolic disorders by promoting the growth of B. intestinihominis . This study suggests that gut commensal B. intestinihominis and puerarin, respectively have the potential as a probiotic and prebiotic in the treatment of T2D.}, archive = {J_ADVS}, author = {Ye Zhang and Dong Xu and Xuyi Cai and Xue Xing and Xin Shao and Ailing Yin and Yanyan Zhao and Mengyuan Wang and Yu-nuo Fan and Boao Liu and Hua Yang and Wei Zhou and Ping Li}, doi = {10.1002/advs.202411181}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2411181}, shortjournal = {Adv. Sci.}, title = {Gut commensal barnesiella intestinihominis ameliorates hyperglycemia and liver metabolic disorders}, volume = {12}, year = {2025}, }
• (2025). Unraveling spatial heterogeneity in mass spectrometry imaging data with GraphMSI. ADVS, 12(8), 2410840. (www)

  @article{ , abstract = {Mass spectrometry imaging (MSI) provides valuable insights into metabolic heterogeneity by capturing in situ molecular profiles within organisms. One challenge of MSI heterogeneity analysis is performing an objective segmentation to differentiate the biological tissue into distinct regions with unique characteristics. However, current methods struggle due to the insufficient incorporation of biological context and high computational demand. To address these challenges, a novel deep learning-based approach is proposed, GraphMSI, which integrates metabolic profiles with spatial information to enhance MSI data analysis. Our comparative results demonstrate GraphMSI outperforms commonly used segmentation methods in both visual inspection and quantitative evaluation. Moreover, GraphMSI can incorporate partial or coarse biological contexts to improve segmentation results and enable more effective three-dimensional MSI segmentation with reduced computational requirements. These are facilitated by two optional enhanced modes: scribble-interactive and knowledge-transfer. Numerous results demonstrate the robustness of these two modes, ensuring that GraphMSI consistently retains its capability to identify biologically relevant sub-regions in complex practical applications. It is anticipated that GraphMSI will become a powerful tool for spatial heterogeneity analysis in MSI data.}, archive = {J_ADVS}, author = {Lei Guo and Peisi Xie and Xionghui Shen and Thomas Ka Yam Lam and Lingli Deng and Chengyi Xie and Xiangnan Xu and Chris Kong Chu Wong and Jingjing Xu and Jiacheng Fang and Xiaoxiao Wang and Zhuang Xiong and Shangyi Luo and Jianing Wang and Jiyang Dong and Zongwei Cai}, doi = {10.1002/advs.202410840}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2410840}, shortjournal = {Adv. Sci.}, title = {Unraveling spatial heterogeneity in mass spectrometry imaging data with GraphMSI}, volume = {12}, year = {2025}, }
• (2025). Molten salt-assisted synthesis of porous precious metal-based single-atom catalysts for oxygen reduction reaction. ADVS, 12(8), 2410784. (www)

  @article{ , abstract = {Precious metal-based single-atom catalysts (PM-SACs) hosted in N-doped carbon supports have shown new opportunities to revolutionize cathodic oxygen reduction reaction (ORR). However, stabilizing the high density of PM-N x sites remains a challenge, primarily due to the inherently high free energy of isolated metal atoms, predisposing them to facile atomic agglomeration. Herein, a molten salt-assisted synthesis strategy is proposed to prepare porous PM 1 /N-C Pores (PM = Ru, Pt, and Pd) electrocatalysts with densely accessible PM-N x sites. A hierarchically porous N-doped carbon substrate (N-C Pores ), synthesized via the NaCl-assisted pyrolysis of zeolitic imidazolate framework-8, effectively improves the utilization of PM-N x sites by increased reactants accessible surface area and reduced mass transfer resistance. In accordance with theoretical calculations, the as-prepared Ru 1 /N-C Pores , featuring superior intrinsic active Ru-N 4 sites, exhibit outstanding ORR turnover frequency of 6.19 e − site −1 s −1 , and outperforms the commercial Pt/C with a 5.3-fold of mass activity (5.83 ± 0.61 A mg −1 ) at 0.8 V versus reversible hydrogen electrode. The commendable activity and stability of Ru 1 /N-C Pores in a real fuel cell device further affirm its practical applicability.}, archive = {J_ADVS}, author = {Chenming Fan and Xin Gao and Pengyi Tang and Qiang Wang and Bing Li}, doi = {10.1002/advs.202410784}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2410784}, shortjournal = {Adv. Sci.}, title = {Molten salt-assisted synthesis of porous precious metal-based single-atom catalysts for oxygen reduction reaction}, volume = {12}, year = {2025}, }
• (2025). End-to-end crystal structure prediction from powder X-ray diffraction. ADVS, 12(8), 2410722. (www)

  @article{ , abstract = {Powder X-ray diffraction (PXRD) is a prevalent technique in materials characterization. While the analysis of PXRD often requires extensive human manual intervention, and most automated method only achieved at coarse-grained level. The more difficult and important task of fine-grained crystal structure prediction from PXRD remains unaddressed. This study introduces XtalNet, the first equivariant deep generative model for end-to-end crystal structure prediction from PXRD. Unlike previous crystal structure prediction methods that rely solely on composition, XtalNet leverages PXRD as an additional condition, eliminating ambiguity and enabling the generation of complex organic structures with up to 400 atoms in the unit cell. XtalNet comprises two modules: a Contrastive PXRD-Crystal Pretraining (CPCP) module that aligns PXRD space with crystal structure space, and a Conditional Crystal Structure Generation (CCSG) module that generates candidate crystal structures conditioned on PXRD patterns. Evaluation on two MOF datasets (hMOF-100 and hMOF-400) demonstrates XtalNet's effectiveness. XtalNet achieves a top-10 Match Rate of 90.2% and 79% for hMOF-100 and hMOF-400 in conditional crystal structure prediction task, respectively. XtalNet enables the direct prediction of crystal structures from experimental measurements, eliminating the need for manual intervention and external databases. This opens up new possibilities for automated crystal structure determination and the accelerated discovery of novel materials.}, archive = {J_ADVS}, author = {Qingsi Lai and Fanjie Xu and Lin Yao and Zhifeng Gao and Siyuan Liu and Hongshuai Wang and Shuqi Lu and Di He and Liwei Wang and Linfeng Zhang and Cheng Wang and Guolin Ke}, doi = {10.1002/advs.202410722}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2410722}, shortjournal = {Adv. Sci.}, title = {End-to-end crystal structure prediction from powder X-ray diffraction}, volume = {12}, year = {2025}, }
• (2025). Rapid stiffness mapping in soft biologic tissues with micrometer resolution using optical multifrequency time-harmonic elastography. ADVS, 12(8), 2410473. (www)

  @article{ , abstract = {Rapid mapping of the mechanical properties of soft biological tissues from light microscopy to macroscopic imaging can transform fundamental biophysical research by providing clinical biomarkers to complement in vivo elastography. This work introduces superfast optical multifrequency time-harmonic elastography (OMTHE) to remotely encode surface and subsurface shear wave fields for generating maps of tissue stiffness with unprecedented detail resolution. OMTHE rigorously exploits the space-time propagation characteristics of multifrequency time-harmonic waves to address current limitations of biomechanical imaging and elastography. Key solutions are presented for stimulation, wave decoding, and stiffness reconstruction of shear waves at multiple harmonic frequencies, all tuned to provide consistent stiffness values across resolutions from microns to millimeters. OMTHE's versatility is demonstrated by simulations, phantoms, Bacillus subtilis biofilms, zebrafish embryos and adult zebrafish, reflecting the diversity of biological systems from a mechanics perspective. By zooming in on stiffness details from coarse to finer scales, OMTHE has the potential to advance mechanobiology and offers a way to perform biomechanics-based tissue histology that consistently matches in vivo time-harmonic elastography in patients.}, archive = {J_ADVS}, author = {Jakob Jordan and Noah Jaitner and Tom Meyer and Luca Bramè and Mnar Ghrayeb and Julia Köppke and Oliver Böhm and Stefan Klemmer Chandia and Vasily Zaburdaev and Liraz Chai and Heiko Tzschätzsch and Joaquin Mura and Jürgen Braun and Anja I.H. Hagemann and Ingolf Sack}, doi = {10.1002/advs.202410473}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2410473}, shortjournal = {Adv. Sci.}, title = {Rapid stiffness mapping in soft biologic tissues with micrometer resolution using optical multifrequency time-harmonic elastography}, volume = {12}, year = {2025}, }
• (2025). ZAR1/2-regulated epigenetic modifications are essential for age-associated oocyte quality maintenance and zygotic activation. ADVS, 12(8), 2410305. (www)

  @article{ , abstract = {The developmental competence and epigenetic progression of oocytes gradually become dysregulated with increasing maternal age. However, the mechanisms underlying age-related epigenetic regulation in oocytes remain poorly understood. Zygote arrest proteins 1 and 2 (ZAR1/2) are two maternal factors with partially redundant roles in maintaining oocyte quality, mainly known by regulating mRNA stability. In addition to this known function, it is found that ZAR1/2 is required for oocyte epigenetic maturation and zygotic reprogramming. Zar1/2 -deleted oocytes exhibited reduced levels of multiple histone modifications and of the expression of corresponding histone modifiers, along with over-condensed chromatin, leading to compromised minor zygotic genome activation and deficient embryo development following fertilization. Cytoplasmic ZAR1/2 participated in intranuclear epigenetic maturation by binding the transcripts encoding histone modifiers and regulating their stability and translational activity. Moreover, oocytes from aged mice exhibited similar histone-modification deficiencies as the Zar1/2 -deleted oocytes. ZAR1/2 mRNA and protein levels are downregulated in oocytes from mice and women with advanced ages, suggesting ZAR1/2 as regulators of epigenetic changes with reproductive aging. This study presents a new nucleo-cytoplasmic interaction mechanism that is involved in preventing oocyte epigenetic aging. Further, ZAR1/2 represents potential gene targets for diagnosis and clinical interventions in age-associated deficiencies in oocyte and embryo development.}, archive = {J_ADVS}, author = {Yan Rong and Yu-Ke Wu and Yingyan Chen and Qing Liu and Leilei Ai and Yun-Wen Wu and Yezhang Zhu and Yin-Li Zhang and Chengkan Liu and Yerong Ma and Xiaomei Tong and Jiamin Jin and Xiaoxuan Li and Yan Zhou and Shu-Yan Ji and Songying Zhang and Heng-Yu Fan}, doi = {10.1002/advs.202410305}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2410305}, shortjournal = {Adv. Sci.}, title = {ZAR1/2-regulated epigenetic modifications are essential for age-associated oocyte quality maintenance and zygotic activation}, volume = {12}, year = {2025}, }
• (2025). Fully 3D-printed soft capacitive sensor of high toughness and large measurement range. ADVS, 12(8), 2410284. (www)

  @article{ , abstract = {Soft capacitive sensors are widely utilized in wearable devices, flexible electronics, and soft robotics due to their high sensitivity. However, they may suffer delamination and/or debonding due to their low interfacial toughness. In addition, they usually exhibit a small measurement range resulting from their limited stiffness variation range. In this paper, soft silicone-based capacitive sensors are developed by using a customized multimaterial 3D printer. By curing silicone materials simultaneously, the continuous conductive and dielectric layers achieve a substantial interfacial toughness of 1036 J·m −2 . The sensor with tilted thin-plate dielectrics exhibits interfacial toughness of 645 J·m −2 or 339 J·m −2 in the transverse or longitudinal direction, respectively. Additionally, the sensors demonstrate a broad measurement range from 0.85 Pa to 5000 kPa. This extended range is facilitated by the significant stiffness variation of the separated tilted thin-plate dielectrics, ranging from 0.56 kPa to 19.76 MPa. Two applications of these fully printed soft sensors, including an intelligent sensorized insole and a robotic hand combining both soft actuators and soft sensors are showcased. It is believed that the strategy, employing 3D printing for soft microstructured sensors, is a general approach not only applicable for improving the performance of soft sensors, but also conducive to designing powerful soft functional devices.}, archive = {J_ADVS}, author = {Fei Xiao and Zhuoheng Wei and Zhipeng Xu and Hao Wang and Jisen Li and Jian Zhu}, doi = {10.1002/advs.202410284}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2410284}, shortjournal = {Adv. Sci.}, title = {Fully 3D-printed soft capacitive sensor of high toughness and large measurement range}, volume = {12}, year = {2025}, }
• (2025). Expanding the functions of KHSRP protein: Insights into DNA G-quadruplex binding. ADVS, 12(8), 2410086. (www)

  @article{ , abstract = {KHSRP (KH-type splicing regulatory protein) is a multifunctional nucleic acid-binding protein that regulates various cellular processes, with critical roles in controlling gene expression. G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in essential cellular activities, including gene expression, and are recognized as potential therapeutic targets in cancer. The biological functions of G4s are mediated by proteins making their formation highly dynamic within cells. Therefore, the recognition of G4s by specific proteins is crucial for modulating physiological and pathological pathways. Given the growing interest in DNA G4s, a deeper understanding of the proteins that interact with them and their molecular recognition is imperative. This study demonstrates that KHSRP binds to these DNA structures. Biophysical analyses provide insights into the thermodynamics, kinetics, and structural aspects of these interactions, showing that G4 structural variability significantly influences KHSRP binding, in which the KH3 protein domain plays a key role. Validation of these interactions in cancer cells further highlights their biological relevance. Notably, the G4 ligand pyridostatin affects KHSRP/G4 interactions both in vitro and in cells, suggesting that small molecules can modulate this molecular recognition. These findings underscore KHSRP's potential role in regulating cellular mechanisms through binding to G4-forming DNA, positioning it as a possible therapeutic target in cancer.}, archive = {J_ADVS}, author = {Pasquale Russomanno and Pasquale Zizza and Linda Cerofolini and Federica D'Aria and Sara Iachettini and Serena Di Vito and Annamaria Biroccio and Jussara Amato and Marco Fragai and Bruno Pagano}, doi = {10.1002/advs.202410086}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2410086}, shortjournal = {Adv. Sci.}, title = {Expanding the functions of KHSRP protein: Insights into DNA G-quadruplex binding}, volume = {12}, year = {2025}, }
• (2025). Mild hyperthermia accelerates bone repair by dynamically regulating iNOS/Arg1 balance in the early stage. ADVS, 12(8), 2409882. (www)

  @article{ , abstract = {Mild hyperthermia therapy has garnered interest as an adjunctive treatment for bone repair. However, its optimal timing, duration, and underlying mechanisms remain unclear. In this study, how mild hyperthermia supports bone repair during the early stages is assesed. These findings reveal that mild hyperthermia accelerates bone regeneration by dynamically regulating inducible nitric oxide synthase/arginase 1 (iNOS/Arg1) balance. This process involves macrophage polarization to the M1 phenotype through iNOS activation, followed by a rapid transition to the M2 phenotype through Arg1 activation after 3 days of sustained mild hyperthermia. RNA-Seq reveals that a single day of mild hyperthermia induced immune alterations aligned with the early inflammatory phase of bone repair, characterized by osteoclast activation, cell recruitment, and neovascularization, thereby preparing for the transition to the repair phase. Experiments involving subcutaneous abscesses, subcutaneous embedding, and critical cranial bone defects further confirm that early mild hyperthermia treatment dynamically regulates macrophage phenotypes. This regulation enhances early antibacterial activity, promotes angiogenesis, and facilitates the transition from inflammation to repair, ultimately accelerating bone-defect repair. This study is the first to elucidate the dual temporal effects of early mild hyperthermia on immune regulation, offering insights into the optimal timing and duration of photothermal therapy following bone repair surgery.}, archive = {J_ADVS}, author = {Jinhui Zhao and Yiping Luo and Lei Zhang and Yunfeng Chen and Yixing Chen and Xinhui Wu and Aihemaitijiang Aierken and Dilixiati Duolikun and Tianlong Wang and Zifei Zhou and Zhiqing Liu and Longpo Zheng}, doi = {10.1002/advs.202409882}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2409882}, shortjournal = {Adv. Sci.}, title = {Mild hyperthermia accelerates bone repair by dynamically regulating iNOS/Arg1 balance in the early stage}, volume = {12}, year = {2025}, }
• (2025). Personalized human astrocyte-derived region-specific forebrain organoids recapitulate endogenous pathological features of focal cortical dysplasia. ADVS, 12(8), 2409774. (www)

  @article{ , abstract = {Focal cortical dysplasia (FCD) is a highly heterogeneous neurodevelopmental malformation, the underlying mechanisms of which remain largely elusive. In this study, personalized dorsal and ventral forebrain organoids (DFOs/VFOs) are generated derived from brain astrocytes of patients with FCD type II (FCD II). The pathological features of dysmorphic neurons, balloon cells, and astrogliosis are successfully replicated in patient-derived DFOs, but not in VFOs. It is noteworthy that cardiomyocyte-like cells correlated with dysmorphic neurons are generated through the high activation of BMP and WNT signaling in some of the FCD-organoids and patient cortical tissues. Moreover, functional assessments demonstrated the occurrence of epileptiform burst firing and propagative self-assembling neuronal hyperactivity in both FCD-DFOs and VFOs. Additionally, the heterotopic cardiomyocyte-organoids demonstrated the capacity for cardiomyocyte contraction and rhythmic firing. The presence of these cardiomyocytes contributes to the hyperactivity of neural networks in cardioids-DFOs assembly. In conclusion, the personalized region-specific forebrain organoids derived from FCD patient astrocytes effectively recapitulate heterogeneous pathological features, offering a valuable platform for the development of precise therapeutic strategies.}, archive = {J_ADVS}, author = {Jinhong Xu and Yufei Kong and Nawen Wang and Huijuan Li and Yunteng Li and Zhuo Liu and Yuling Yang and Xiao Yu and Huihui Liu and Jing Ding and Yi Wang and Rui Zhao and Zhicheng Shao}, doi = {10.1002/advs.202409774}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2409774}, shortjournal = {Adv. Sci.}, title = {Personalized human astrocyte-derived region-specific forebrain organoids recapitulate endogenous pathological features of focal cortical dysplasia}, volume = {12}, year = {2025}, }
• (2025). Defining structure-function relationships of amphiphilic excipients enables rational design of ultra-stable biopharmaceuticals. ADVS, 12(8), 2409604. (www)

  @article{ , abstract = {Biopharmaceuticals are the fastest-growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and poloxamers are used to prevent protein aggregation, which significantly extends shelf-life. Unfortunately, these excipients are themselves unstable, oxidizing rapidly into 100s of distinct compounds, some of which cause severe adverse events in patients. Here, the highly stable, well-defined, and modular nature of amphiphilic polyacrylamide-derived excipients is leveraged to isolate the key mechanisms responsible for excipient-mediated protein stabilization. With a library of compositionally identical but structurally distinct amphiphilic excipients, a new property is quantified, compositional dispersity, that is key to excipient performance and utilized this property to rationally design new ultra-stable surfactant excipients that increase the stability of a notoriously unstable biopharmaceutical, monomeric insulin, by an order of magnitude. This comprehensive and generalizable understanding of excipient structure-function relationships represents a paradigm shift for the formulation of biopharmaceuticals, moving away from trial-and-error screening approaches toward rational design.}, archive = {J_ADVS}, author = {Alexander N. Prossnitz and Leslee T. Nguyen and Noah Eckman and Suraj Borkar and Samantha Tetef and Anton A. A. Autzen and Gerald G. Fuller and Eric A. Appel}, doi = {10.1002/advs.202409604}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2409604}, shortjournal = {Adv. Sci.}, title = {Defining structure-function relationships of amphiphilic excipients enables rational design of ultra-stable biopharmaceuticals}, volume = {12}, year = {2025}, }
• (2025). Stabilizing schottky-to-ohmic switching in HfO2-based ferroelectric films via electrode design. ADVS, 12(8), 2409566. (www)

  @article{ , abstract = {The discovery of ferroelectric phases in HfO 2 -based films has reignited interest in ferroelectrics and their application in resistive switching (RS) devices. This study investigates the pivotal role of electrodes in facilitating the Schottky-to-Ohmic transition (SOT) observed in devices consisting of ultrathin epitaxial ferroelectric Hf 0.93 Y 0.07 O 2 (YHO) films deposited on La 0.67 Sr 0.33 MnO 3 -buffered Nb-doped SrTiO 3 (NbSTO|LSMO) with Ti|Au top electrodes. These findings indicate combined filamentary RS and ferroelectric switching occurs in devices with designed electrodes, having an ON/OFF ratio of over 100 during about 10 5 cycles. Transport measurements of modified device stacks show no change in SOT when the ferroelectric YHO layer is replaced with an equivalent hafnia-based layer, Hf 0.5 Zr 0.5 O 2 (HZO). However, incomplete SOT is observed for variations in the top electrode thickness or material, as well as LSMO electrode thickness. This underscores the importance of employing oxygen-reactive electrodes and a bottom electrode with reduced conductivity to stabilize SOT. These findings provide valuable insights for enhancing the performance of ferroelectric RS devices through integration with filamentary RS mechanism.}, archive = {J_ADVS}, author = {Moritz L. Müller and Nives Strkalj and Maximilian T. Becker and Megan O. Hill and Ji Soo Kim and Dibya Phuyal and Simon M. Fairclough and Caterina Ducati and Judith L. MacManus-Driscoll}, doi = {10.1002/advs.202409566}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2409566}, shortjournal = {Adv. Sci.}, title = {Stabilizing schottky-to-ohmic switching in HfO2-based ferroelectric films via electrode design}, volume = {12}, year = {2025}, }
• (2025). Tailoring robust 2D nanochannels by radical polymerization for efficient molecular sieving. ADVS, 12(8), 2409556. (www)

  @article{ , abstract = {Two-dimensional (2D) nanochannels have demonstrated outstanding performance for sieving specific molecules or ions, owing to their uniform molecular channel sizes and interlayer physical/chemical properties. However, controllably tuning nanochannel spaces with specific sizes and simultaneously achieving high mechanical strength remain the main challenges. In this work, the inter-sheet gallery d-spacing of graphene oxide (GO) membrane is successfully tailored with high mechanical strength via a general radical-induced polymerization strategy. The introduced amide groups from N-Vinylformamide significantly reinforce the 2D nanochannels within the freestanding membranes, resulting in an ultrahigh tensile strength of up to 105 MPa. The d-spacing of the membrane is controllably tuned within a range of 0.799–1.410 nm, resulting in a variable water permeance of up to 218 L m −2 h −1 bar −1 (1304% higher than that of the pristine GO membranes). In particular, the tailored membranes demonstrate excellent water permeance stability (140 L m −2 h −1 bar −1 ) in a 200-h long-term operation and high selectivity of solutes under harsh conditions, including a wide range of pH from 4.0 to 10.0, up to a loading pressure of 12 bar and an external temperature of 40 °C. This approach comprehensively achieves a balance between sieving performance and mechanical strength, satisfying the requirements for the next-generation molecular sieving membranes.}, archive = {J_ADVS}, author = {Yue You and Yuxi Ma and Xianghui Zeng and Yichao Wang and Juan Du and Yijun Qian and Guoliang Yang and Yuyu Su and Weiwei Lei and Shuaifei Zhao and Yan Qing and Yiqiang Wu and Jingliang Li}, doi = {10.1002/advs.202409556}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2409556}, shortjournal = {Adv. Sci.}, title = {Tailoring robust 2D nanochannels by radical polymerization for efficient molecular sieving}, volume = {12}, year = {2025}, }
• (2025). Wet photolithography from hydrogen abstraction of a quasi-orthogonal aggregation-induced emitter. ADVS, 12(8), 2408979. (www)

  @article{ , abstract = {A new aggregation-induced emission (AIE) luminogen is obtained by dimerizing acridin-9(10H)-one (Ac), an aggregation-caused quenching (ACQ) effect monomer via an N─N bond and forming 9H,9′H-[10,10′-biacridine]-9,9′-dione (DiAc) with D 2d symmetry. The quenching of DiAc in solution is ascribed to the enhanced basicity promoting hydrogen bonding and then a hydrogen abstraction (HA) reaction and/or an unallowed transition in frontier orbitals with the same symmetry facilitating intersystem crossing. It is found that emissive Ac is one product of the non-emissive DiAc solution in the HA reaction activated by UV irradiation. By exploiting the AIE properties and the HA reaction of DiAc, photolithographic patterning is demonstrated with a paper wetted with DiAc solution.}, archive = {J_ADVS}, author = {Chen Cao and Huan Chen and Jia-Ming Jin and Ji-Hua Tan and Hong-Ji Tan and Jiu-Dong Lin and Wen-Cheng Chen and Yi Yuan and Ze-Lin Zhu and Chun-Sing Lee}, doi = {10.1002/advs.202408979}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2408979}, shortjournal = {Adv. Sci.}, title = {Wet photolithography from hydrogen abstraction of a quasi-orthogonal aggregation-induced emitter}, volume = {12}, year = {2025}, }
• (2025). Inhibition of CDH11 activates cGAS-STING by stimulating branched chain amino acid catabolism and mitigates lung metastasis of adenoid cystic carcinoma. ADVS, 12(8), 2408751. (www)

  @article{ , abstract = {Salivary adenoid cystic carcinoma (SACC) is an intractable malignant tumor originates in the secretory glands and frequently metastasizes to the lungs. Hybrid epithelial-mesenchymal transition (EMT) cells within the tumors are correlated with augmented proliferative capacity and facilitation of lung metastasis. Single-cell RNA sequencing and spatial transcriptomic sequencing are employed to reveal the hybrid EMT subsets within the vascular fibroblast microenvironment. These hybrid EMT cells exhibit a pro-tumorigenic impact in vitro. Notably, cadherin 11 (CDH11), a specific marker for hybrid EMT cells, may exert its regulatory role in cellular function by interfering with branched-chain amino acids (BCAA) metabolism by inhibiting branched-chain ketoacid dehydrogenase to activate the mammalian target of the rapamycin pathway, thus making it a potential therapeutic target for SACC. Furthermore, celecoxib and its derivatives are specific CDH11 inhibitors that regulate BCAA metabolism, increase reactive oxygen species production, and subsequently activate the cyclic GMP-AMP synthase-stimulator of the interferongene pathway (cGAS-STING). They also inhibit lung metastasis in NOD-SCID mice in vivo. Overall, these findings suggest a promising treatment strategy that targets hybrid EMT cells to mitigate lung metastasis in SACC. Celecoxib may serve as a promising clinical intervention for the treatment of lung metastases in patients with SACC.}, archive = {J_ADVS}, author = {Rui-Feng Li and Shuo Liu and Qian Gao and Min Fu and Xin-Yi Sun and Mian Xiao and Xi-Yuan Ge and Xin Peng}, doi = {10.1002/advs.202408751}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2408751}, shortjournal = {Adv. Sci.}, title = {Inhibition of CDH11 activates cGAS-STING by stimulating branched chain amino acid catabolism and mitigates lung metastasis of adenoid cystic carcinoma}, volume = {12}, year = {2025}, }
• (2025). Generation of multiple-depth 3D computer-generated holograms from 2D-image-datasets trained CNN. ADVS, 12(8), 2408610. (www)

  @article{ , abstract = {Generating computer-generated holograms (CGHs) for 3D scenes by learning-based methods can reconstruct arbitrary 3D scenes with higher quality and faster speed. However, the homogenization and difficulty of obtaining 3D high-resolution datasets seriously limit the generalization ability of the model. A novel approach is proposed to train 3D encoding models based on convolutional neural networks (CNNs) using 2D image datasets. This technique produces virtual depth (VD) images with a statistically uniform distribution. This approach employs a CNN trained with the angular spectrum method (ASM) for calculating diffraction fields layer by layer. A fully convolutional neural network architecture for phase-only encoding, which is trained on the DIV2K-VD dataset. Experimental results validate its effectiveness by generating a 4K phase-only hologram within only 0.061 s, yielding high-quality holograms that have an average PSNR of 34.7 dB along with an SSIM of 0.836, offering high quality, economic and time efficiencies compared to traditional methods.}, archive = {J_ADVS}, author = {Xingpeng Yan and Jiaqi Li and Yanan Zhang and Hebin Chang and Hairong Hu and Tao Jing and Hanyu Li and Yang Zhang and Jinhong Xue and Xunbo Yu and Xiaoyu Jiang}, doi = {10.1002/advs.202408610}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2408610}, shortjournal = {Adv. Sci.}, title = {Generation of multiple-depth 3D computer-generated holograms from 2D-image-datasets trained CNN}, volume = {12}, year = {2025}, }
• (2025). Triboelectric bending sensors for AI-enabled sign language recognition. ADVS, 12(8), 2408384. (www)

  @article{ , abstract = {Human–machine interfaces and wearable electronics, as fundamentals to achieve human-machine interactions, are becoming increasingly essential in the era of the Internet of Things. However, contemporary wearable sensors based on resistive and capacitive mechanisms demand an external power, impeding them from extensive and diverse deployment. Herein, a smart wearable system is developed encompassing five arch-structured self-powered triboelectric sensors, a five-channel data acquisition unit to collect finger bending signals, and an artificial intelligence (AI) methodology, specifically a long short-term memory (LSTM) network, to recognize signal patterns. A slider-crank mechanism that precisely controls the bending angle is designed to quantitively assess the sensor's performance. Thirty signal patterns of sign language of each letter are collected and analyzed after the environment noise and cross-talks among different channels are reduced and removed, respectively, by leveraging low pass filters. Two LSTM models are trained using different training sets, and four indexes are introduced to evaluate their performance, achieving a recognition accuracy of 96.15%. This work demonstrates a novel integration of triboelectric sensors with AI for sign language recognition, paving a new application avenue of triboelectric sensors in wearable electronics.}, archive = {J_ADVS}, author = {Wei Wang and Xiangkun Bo and Weilu Li and Abdelrahman B. M. Eldaly and Lingyun Wang and Wen Jung Li and Leanne Lai Hang Chan and Walid A. Daoud}, doi = {10.1002/advs.202408384}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2408384}, shortjournal = {Adv. Sci.}, title = {Triboelectric bending sensors for AI-enabled sign language recognition}, volume = {12}, year = {2025}, }
• (2025). Solvation dynamics of thermoresponsive polymer films: The influence of salt series in water and mixed Water/Methanol atmosphere. ADVS, 12(8), 2408073. (www)

  @article{ , abstract = {Understanding the salt effects on solvation behaviors of thermoresponsive polymers is crucial for designing and optimizing responsive systems suitable for diverse environments. In this work, the effect of potassium salts (CH 3 COOK, KCl, KBr, KI, and KNO 3 ) on solvation dynamics of poly(4-( N -(3'-methacrylamidopropyl)- N,N -dimethylammonio) butane-1-sulfonate) (PSBP), poly( N -isopropylmethacrylamide) (PNIPMAM), and PSBP- b -PNIPMAM films is investigated under saturated water and mixed water/methanol vapor via advanced in situ neutron/optical characterization techniques. These findings reveal that potassium salts enhance the films' hygroscopicity or methanol-induced swellability. Interestingly, the anions effects do not mirror the empirical Hofmeister series, which describes the salting-in effects for such polymers in dilute aqueous solution, particularly evident in PSBP films with an approximately inverted order. PNIPMAM and PSBP- b -PNIPMAM exhibit pronounced deviations from such an inverted correlation and vary somewhat for water-rich and methanol-rich atmospheres. Molecular dynamics (MD) simulations suggest that the observed orders of solvation result from the accessibility of the hydrated solvation shells close to the PSBP- b -PNIPMAM chains.}, archive = {J_ADVS}, author = {Peixi Wang and Tianle Zheng and Julija Reitenbach and Simon A. Wegener and Linus F. Huber and Lucas P. Kreuzer and Suzhe Liang and Robert Cubitt and Ya-Jun Cheng and Tonghui Xu and Viet Hildebrand and André Laschewsky and Christine M. Papadakis and Peter Müller-Buschbaum}, doi = {10.1002/advs.202408073}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2408073}, shortjournal = {Adv. Sci.}, title = {Solvation dynamics of thermoresponsive polymer films: The influence of salt series in water and mixed Water/Methanol atmosphere}, volume = {12}, year = {2025}, }
• (2025). High-throughput formation of pre-vascularized hiPSC-derived hepatobiliary organoids on a chip via nonparenchymal cell grafting. ADVS, 12(8), 2407945. (www)

  @article{ , abstract = {Liver organoids have been increasingly adopted as a critical in vitro model to study liver development and diseases. However, the pre-vascularization of liver organoids without affecting liver parenchymal specification remains a long-lasting challenge, which is essential for their application in regenerative medicine. Here, the large-scale formation of pre-vascularized human hepatobiliary organoids (vhHBOs) is presented without affecting liver epithelial specification via a novel strategy, namely nonparenchymal cell grafting (NCG). Endothelial and mesenchymal cells are grafted to human hepatobiliary organoids (hHBOs) at the different liver epithelial differentiation stages without supplementing with nonparenchymal culture medium and growth factors. Endothelial grafting at the stage of hepatic maturation offers an optimal integration efficiency compared to the stage of hepatic specification. Additionally, grafting with mesenchymal proves crucial in endothelial invading and sprouting into the liver epithelial cells during the establishment of vhHBOs. Ectopic liver implants into mice further displayed integration of vhHBOs into mice vascular networks. Notably, transplanted vhHBOs self-organized into native liver tissue like hepatic zone and bile ducts, indicating their potential to regenerate damaged hepatic and bile duct tissues. It is believed that nonparenchymal cell grafting will offer a novel technical route to form a high-fidelity complex in vitro model for tissue engineering and regenerative medicine.}, archive = {J_ADVS}, author = {Han Fan and Jia Shang and Junbo Li and Bo Yang and Ding Zhou and Shanqing Jiang and Yuhang Fan and Ying Zhou and Yuwen Wang and Peidi Liu and Changyong Li and Zhishui Chen and Pu Chen}, doi = {10.1002/advs.202407945}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2407945}, shortjournal = {Adv. Sci.}, title = {High-throughput formation of pre-vascularized hiPSC-derived hepatobiliary organoids on a chip via nonparenchymal cell grafting}, volume = {12}, year = {2025}, }
• (2025). A smart semi-implantable device integrating microchannel-enhanced sampling and multiplex biochemical testing for deep wound monitoring and pathogen identification. ADVS, 12(8), 2407868. (www)

  @article{ , abstract = {Monitoring deep wounds is challenging but necessary for high-quality medical treatment. Current methodologies for deep wound monitoring are typically limited to indirect clinical symptoms or costly non-real-time imaging diagnosis. Herein, a smart system is proposed that enables in situ monitoring of deep wounds’ status through a semi-implantable device composed of 2 seamlessly connected functional components: 1) the well-designed, microchannel-structured sampling needles that efficiently and conveniently collect samples from deep wound anatomical locations, and 2) the multiplex biochemical testing compartment that facilitates the immediate and persistent detection of multiple biochemical indicators based on a color image processing software accessible to a conventional smartphone. With the 3 representative preclinical deep wound models, the study demonstrates the device's potential to monitor wound infection, inflammation, healing progress, and reduce inflammation when applied to deep skin injury, surgical implantation, and postoperative intestinal leakage. The device's capability to rapidly and accurately identify pathogenic bacteria is also demonstrated both in vitro and in vivo, potentially facilitating precise intervention in infected wounds. Coupled with the device's favorable biocompatibility and cost-effectiveness, this intelligent system emerges as a promising tool for safe and effective management of complicated deep wounds.}, archive = {J_ADVS}, author = {Qilin Li and Chunyu Wei and Luming Xu and Jiao Zhang and Yuyu Li and Xiaohuan Lu and Rengui Xu and Honglian Guo and Peng Cao and Chenke Ouyang and Jiarong Xu and Wei Chen and Zheng Wang and Lin Wang}, doi = {10.1002/advs.202407868}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2407868}, shortjournal = {Adv. Sci.}, title = {A smart semi-implantable device integrating microchannel-enhanced sampling and multiplex biochemical testing for deep wound monitoring and pathogen identification}, volume = {12}, year = {2025}, }
• (2025). A novel RAGE modulator induces soluble RAGE to reduce BACE1 expression in alzheimer's disease. ADVS, 12(8), 2407812. (www)

  @article{ , abstract = {β-secretase (BACE1) is instrumental in amyloid-β (Aβ) production, with overexpression noted in Alzheimer's disease (AD) neuropathology. The interaction of Aβ with the receptor for advanced glycation endproducts (RAGE) facilitates cerebral uptake of Aβ and exacerbates its neurotoxicity and neuroinflammation, further augmenting BACE1 expression. Given the limitations of previous BACE1 inhibition efforts, the study explores reducing BACE1 expression to mitigate AD pathology. The research reveals that the anticancer agent 6-thioguanosine (6-TG) markedly diminishes BACE1 expression without eliciting cytotoxicity while enhancing microglial phagocytic activity, and ameliorate cognitive impairments with reducing Aβ accumulation in AD mice. Leveraging advanced deep learning-based tool for target identification, and corroborating with surface plasmon resonance assays, it is elucidated that 6-TG directly interacts with RAGE, modulating BACE1 expression through the JAK2-STAT1 pathway and elevating soluble RAGE (sRAGE) levels in the brain. The findings illuminate the therapeutic potential of 6-TG in ameliorating AD manifestations and advocate for small molecule strategies to increase brain sRAGE levels, offering a strategic alternative to the challenges posed by the complexity of AD.}, archive = {J_ADVS}, author = {Seung-Hyun Baek and Suji Hong and Eunae Kim and Sunyoung Park and Minyoung Lee and Jinsu Park and Yoonsuk Cho and Hyunjun Yoon and Daeseung Kim and Youngkwang Yun and Youbin Kim and Yoonjung Choi and Keunsoo Kang and Sangyong Jung and Jun Pyo Kim and Eunha Kim and Sang Won Seo and Yong-Keun Jung and Dong-Gyu Jo}, doi = {10.1002/advs.202407812}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2407812}, shortjournal = {Adv. Sci.}, title = {A novel RAGE modulator induces soluble RAGE to reduce BACE1 expression in alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Effective gene expression prediction and optimization from protein sequences. ADVS, 12(8), 2407664. (www)

  @article{ , abstract = {High soluble protein expression in heterologous hosts is crucial for various research and applications. Despite considerable research on the impact of codon usage on expression levels, the relationship between protein sequence and expression is often overlooked. In this study, a novel connection between protein expression and sequence is uncovered, leading to the development of SRAB (Strength of Relative Amino Acid Bias) based on AEI (Amino Acid Expression Index). The AEI served as an objective measure of this correlation, with higher AEI values enhancing soluble expression. Subsequently, the pre-trained protein model MP-TRANS (MindSpore Protein Transformer) is developed and fine-tuned using transfer learning techniques to create 88 prediction models (MPB-EXP) for predicting heterologous expression levels across 88 species. This approach achieved an average accuracy of 0.78, surpassing conventional machine learning methods. Additionally, a mutant generation model, MPB-MUT, is devised and utilized to enhance expression levels in specific hosts. Experimental validation demonstrated that the top 3 mutants of xylanase (previously not expressed in Escherichia coli ) successfully achieved high-level soluble expression in E. coli . These findings highlight the efficacy of the developed model in predicting and optimizing gene expression based on protein sequences.}, archive = {J_ADVS}, author = {Tuoyu Liu and Yiyang Zhang and Yanjun Li and Guoshun Xu and Han Gao and Pengtao Wang and Tao Tu and Huiying Luo and Ningfeng Wu and Bin Yao and Bo Liu and Feifei Guan and Huoqing Huang and Jian Tian}, doi = {10.1002/advs.202407664}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2407664}, shortjournal = {Adv. Sci.}, title = {Effective gene expression prediction and optimization from protein sequences}, volume = {12}, year = {2025}, }
• (2025). Direct observation of anisotropic coulomb interaction in a topological nodal line semimetal. ADVS, 12(8), 2407437. (www)

  @article{ , abstract = {The fundamental characteristics of collective interactions in topological band structures can be revealed by the exploration of charge screening in topological materials. In particular, distinct anisotropic screening behaviors are predicted to occur in Dirac nodal line semimetals (DNLSMs) due to their peculiar anisotropic low-energy dispersion. Despite the recent extensive theoretical research, experimental observations of exotic charge screening in DNLSMs remain elusive, which is partly attributed to the coexisting trivial bands near the Fermi energy. This study reports the first direct observation of highly anisotropic charge-screening behavior in the DNLSM SrAs 3 . Through atomically resolved conductance measurements, a highly anisotropic charge-screening pattern around charged impurities on a surface is demonstrated. Moreover, the combination of model studies and first-principles calculations reveals the unique nature of the screening anisotropy in DNLSMs. The results of this study are expected to pave the way for understanding the profound collective behavior of interacting low-energy fermions in topological materials.}, archive = {J_ADVS}, author = {Hyo Won Kim and Junseo Jung and Gahee Lee and Taesu Park and Won-Jun Jang and Hoil Kim and Jun Sung Kim and Ji Hoon Shim and Bohm-Jung Yang and Sangjun Jeon}, doi = {10.1002/advs.202407437}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2407437}, shortjournal = {Adv. Sci.}, title = {Direct observation of anisotropic coulomb interaction in a topological nodal line semimetal}, volume = {12}, year = {2025}, }
• (2025). Genomic patterns are associated with different sequelae of patients with long-term COVID-19. ADVS, 12(8), 2407342. (www)

  @article{ , abstract = {In the post-large era, various COVID-19 sequelae are getting more and more attention to health problems. Although the mortality rate of the COVID-19 infection is now declining, it is often accompanied by new clinical sequelae with different symptoms such as fatigue after infection, loss of smell. The degree of age, gender, virus infection seems to be weakly correlated with clinical symptoms. Human genetic variation plays a significant role in the sequelae of the COVID-19 infection. This study aims to analyze the genomic differences between individuals with different COVID-19 sequelae. In this study, the exomes of 97 patients with Omicron with 8 unique clinical manifestations are sequenced, and conducted a systematic analysis. Based on non-negative matrix factorization algorithms, the trinucleotide mutation spectrum of four long-term COVID-19 genomes is summarized and found that individuals with different clinical symptoms have unique DNA mutation patterns and indel patterns. By constructing a Genomic Fingerprinting Framework, the driver genes of variation in each symptomatic population are deciphered and analyzed. This study showed that population-specific mutational fingerprint differences are the main cause of heterogeneity in long-term COVID-19 sequelae. This study provides new ideas and insights into the causes of the long-term COVID-19 sequelae.}, archive = {J_ADVS}, author = {Nan Zhang and Xizi Luo and Xiangwen Ji and Tian Tian and Runze Wu and Shishun Zhao and Guoqing Wang}, doi = {10.1002/advs.202407342}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2407342}, shortjournal = {Adv. Sci.}, title = {Genomic patterns are associated with different sequelae of patients with long-term COVID-19}, volume = {12}, year = {2025}, }
• (2025). Directed inward migration of S-vacancy in Bi2S3 QDs for selective photocatalytic CO2 to CH3OH. ADVS, 12(8), 2406925. (www)

  @article{ , abstract = {The directional migration of S-vacancy is beneficial to the separation of photogenerated carriers and the transition of electrons in semiconductors. In this study, Bi x /Bi 2−x S y @carboxylic-cellulose (CC) photocatalyst with bionic chloroplast structure is obtained by electron beam irradiation to induce S-vacancy in Bi 2 S 3 @CC. The results of CO 2 photoreduction experiments demonstrate that the reduction rate of CO 2 to CH 3 OH by Bi x /Bi 2‒x S 2.89 @CC-450 samples is 10.74 µmol·g −1 ·h −1 , and the selectivity is 92.82%. The results show that the inward migration behavior of the borderline S-vacancy (b-S v ) induces the redistribution of electrons in Bi x /Bi 2−x S y @CC. The Bi° clusters in Bi x /Bi 2−x S y @CC is conducive to adsorb CO 2 , and the internal S-vacancy (i-S v ) is conducive to adsorb CH 3 OH, which accelerate the transfer of gas-phase products to realize the controllable conversion of CO 2 and photoreduction products at the gas–liquid–solid three-phase interface. This study provides a new idea for the development and utilization of green photocatalysts in clean energy.}, archive = {J_ADVS}, author = {Jing Wang and Wenlei Wang and Yao Deng and Zhen Zhang and Hui Wang and Yiqiang Wu}, doi = {10.1002/advs.202406925}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2406925}, shortjournal = {Adv. Sci.}, title = {Directed inward migration of S-vacancy in Bi2S3 QDs for selective photocatalytic CO2 to CH3OH}, volume = {12}, year = {2025}, }
• (2025). Global relative importance of denitrification and anammox in microbial nitrogen loss across terrestrial and aquatic ecosystems. ADVS, 12(8), 2406857. (www)

  @article{ , abstract = {Denitrification and anaerobic ammonium oxidation (anammox) are the major microbial processes responsible for global nitrogen (N) loss. Yet, the relative contributions of denitrification and anammox to N loss across contrasting terrestrial and aquatic ecosystems worldwide remain unclear, hampering capacities to predict the human alterations in the global N cycle. Here, a global synthesis including 3240 observations from 199 published isotope pairing studies is conducted and finds that denitrification governs microbial N loss globally (79.8±0.4%). Significantly, anammox is more important in aquatic than terrestrial ecosystems worldwide and can contribute up to 43.2% of N loss in global seawater. Global maps for N loss associated with denitrification and anammox are further generated and show that the contribution of anammox to N loss decreases with latitude for soils and sediments but generally increases with substrate depth. This work highlights the importance of anammox as well as denitrification in driving ecosystem N losses, which is critical for improving the current global N cycle model and achieving sustainable N management.}, archive = {J_ADVS}, author = {Gang He and Danli Deng and Manuel Delgado-Baquerizo and Wenzhi Liu and Quanfa Zhang}, doi = {10.1002/advs.202406857}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2406857}, shortjournal = {Adv. Sci.}, title = {Global relative importance of denitrification and anammox in microbial nitrogen loss across terrestrial and aquatic ecosystems}, volume = {12}, year = {2025}, }
• (2025). SEE: A method for predicting the dynamics of chromatin conformation based on single-cell gene expression. ADVS, 12(8), 2406413. (www)

  @article{ , abstract = {The dynamics of chromatin conformation involve continuous and reversible changes within the nucleus of a cell, which participate in regulating processes such as gene expression, DNA replication, and damage repair. Here, SEE is introduced, an artificial intelligence (AI) method that utilizes autoencoder and transformer techniques to analyze chromatin dynamics using single-cell RNA sequencing data and a limited number of single-cell Hi-C maps. SEE is employed to investigate chromatin dynamics across different scales, enabling the detection of (i) rearrangements in topologically associating domains (TADs), and (ii) oscillations in chromatin interactions at gene loci. Additionally, SEE facilitates the interpretation of disease-associated single-nucleotide polymorphisms (SNPs) by leveraging the dynamic features of chromatin conformation. Overall, SEE offers a single-cell, high-resolution approach to analyzing chromatin dynamics in both developmental and disease contexts.}, archive = {J_ADVS}, author = {Minghong Li and Yurong Yang and Rucheng Wu and Haiyan Gong and Zan Yuan and Jixin Wang and Erping Long and Xiaotong Zhang and Yang Chen}, doi = {10.1002/advs.202406413}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2406413}, shortjournal = {Adv. Sci.}, title = {SEE: A method for predicting the dynamics of chromatin conformation based on single-cell gene expression}, volume = {12}, year = {2025}, }
• (2025). RTN4IP1 contributes to ESCC via regulation of amino acid transporters. ADVS, 12(8), 2406220. (www)

  @article{ , abstract = {Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of esophageal cancer cases. The lack of effective therapeutic targets makes it difficult to improve the overall survival of patients with ESCC. Reticulon 4 Interacting Protein 1 (RTN4IP1) is a novel mitochondrial oxidoreductase. Here, a notable upregulation of RTN4IP1 is demonstrated, which is associated with poor survival in patients with ESCC. RTN4IP1 depletion impairs cell proliferation and induces apoptosis of ESCC cells. Furthermore, c-Myc regulates RTN4IP1 expression via iron regulatory protein 2 (IRP2) at the post-transcriptional level. Mechanistically, RTN4IP1 mRNA harbors functional iron-responsive elements (IREs) in the 3′ UTR, which can be targeted by IRP2, resulting in increased mRNA stability. Finally, RTN4IP1 depletion abrogates amino acid uptake and induces amino acid starvation via downregulation of the amino acid transporters SLC1A5, SLC3A2, and SLC7A5, indicating a possible pathway through which RTN4IP1 contributes to ESCC carcinogenesis and progression. In vivo studies using cell-derived xenograft and patient-derived xenograft mouse models as well as a 4-nitroquinoline 1-oxide-induced ESCC model in esophageal-specific Rtn4ip1 knockout mice demonstrate the essential role of RTN4IP1 in ESCC development. Thus, RTN4IP1 emerges as a key cancer-promoting protein in ESCC, suggesting therapeutic RTN4IP1 suppression as a promising strategy for ESCC treatment.}, archive = {J_ADVS}, author = {Huifang Wei and Dengyun Zhao and Yafei Zhi and Qiong Wu and Jing Ma and Jialuo Xu and Tingting Liu and Jing Zhang and Penglei Wang and Yamei Hu and Xinyu He and Fangqin Guo and Ming Jiang and Dandan Zhang and Wenna Nie and Ran Yang and Tongjin Zhao and Zigang Dong and Kangdong Liu}, doi = {10.1002/advs.202406220}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2406220}, shortjournal = {Adv. Sci.}, title = {RTN4IP1 contributes to ESCC via regulation of amino acid transporters}, volume = {12}, year = {2025}, }
• (2025). Highly self-adhesive and biodegradable silk bioelectronics for all-in-one imperceptible long-term electrophysiological biosignals monitoring. ADVS, 12(8), 2405988. (www)

  @article{ , abstract = {Skin-like bioelectronics offer a transformative technological frontier, catering to continuous and real-time yet highly imperceptible and socially discreet digital healthcare. The key technological breakthrough enabling these innovations stems from advancements in novel material synthesis, with unparalleled possibilities such as conformability, miniature footprint, and elasticity. However, existing solutions still lack desirable properties like self-adhesivity, breathability, biodegradability, transparency, and fail to offer a streamlined and scalable fabrication process. By addressing these challenges, inkjet-patterned protein-based skin-like silk bioelectronics (Silk-BioE) are presented, that integrate all the desirable material features that have been individually present in existing devices but never combined into a single embodiment. The all-in-one solution possesses excellent self-adhesiveness (300 N m −1 ) without synthetic adhesives, high breathability (1263 g h −1 m −2 ) as well as swift biodegradability in soil within a mere 2 days. In addition, with an elastic modulus of ≈5 kPa and a stretchability surpassing 600%, the soft electronics seamlessly replicate the mechanics of epidermis and form a conformal skin/electrode interface even on hairy regions of the body under severe perspiration. Therefore, coupled with a flexible readout circuitry, Silk-BioE can non-invasively monitor biosignals (i.e., ECG, EEG, EOG) in real-time for up to 12 h with benchmarking results against Ag/AgCl electrodes.}, archive = {J_ADVS}, author = {Seyed Sajjad Mirbakht and Ata Golparvar and Muhammad Umar and Burcu Arman Kuzubasoglu and Farid Sayar Irani and Murat Kaya Yapici}, doi = {10.1002/advs.202405988}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2405988}, shortjournal = {Adv. Sci.}, title = {Highly self-adhesive and biodegradable silk bioelectronics for all-in-one imperceptible long-term electrophysiological biosignals monitoring}, volume = {12}, year = {2025}, }
• (2025). Multi-physical lattice metamaterials enabled by additive manufacturing: Design principles, interaction mechanisms, and multifunctional applications. ADVS, 12(8), 2405835. (www)

  @article{ , abstract = {Lattice metamaterials emerge as advanced architected materials with superior physical properties and significant potential for lightweight applications. Recent developments in additive manufacturing (AM) techniques facilitate the manufacturing of lattice metamaterials with intricate microarchitectures and promote their applications in multi-physical scenarios. Previous reviews on lattice metamaterials have largely focused on a specific/single physical field, with limited discussion on their multi-physical properties, interaction mechanisms, and multifunctional applications. Accordingly, this article critically reviews the design principles, structure-mechanism-property relationships, interaction mechanisms, and multifunctional applications of multi-physical lattice metamaterials enabled by AM techniques. First, lattice metamaterials are categorized into homogeneous lattices, inhomogeneous lattices, and other forms, whose design principles and AM processes are critically discussed, including the benefits and drawbacks of different AM techniques for fabricating different types of lattices. Subsequently, the structure–mechanism–property relationships and interaction mechanisms of lattice metamaterials in a range of physical fields, including mechanical, acoustic, electromagnetic/optical, and thermal disciplines, are summarized to reveal critical design principles. Moreover, the multifunctional applications of lattice metamaterials, such as sound absorbers, insulators, and manipulators, sensors, actuators, and soft robots, thermal management, invisible cloaks, and biomedical implants, are enumerated. These design principles and structure-mechanism-property relationships provide effective design guidelines for lattice metamaterials in multifunctional applications.}, archive = {J_ADVS}, author = {Winston Wai Shing Ma and Hang Yang and Yijing Zhao and Xinwei Li and Junhao Ding and Shuo Qu and Quyang Liu and Zongxin Hu and Rui Li and Quanqing Tao and Haoming Mo and Wei Zhai and Xu Song}, doi = {10.1002/advs.202405835}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2405835}, shortjournal = {Adv. Sci.}, title = {Multi-physical lattice metamaterials enabled by additive manufacturing: Design principles, interaction mechanisms, and multifunctional applications}, volume = {12}, year = {2025}, }
• (2025). Non-invasive diagnosis of moyamoya disease using serum metabolic fingerprints and machine learning. ADVS, 12(8), 2405580. (www)

  @article{ , abstract = {Moyamoya disease (MMD) is a progressive cerebrovascular disorder that increases the risk of intracranial ischemia and hemorrhage. Timely diagnosis and intervention can significantly reduce the risk of new-onset stroke in patients with MMD. However, the current diagnostic methods are invasive and expensive, and non-invasive diagnosis using biomarkers of MMD is rarely reported. To address this issue, nanoparticle-enhanced laser desorption/ionization mass spectrometry (LDI MS) was employed to record serum metabolic fingerprints (SMFs) with the aim of establishing a non-invasive diagnosis method for MMD. Subsequently, a diagnostic model was developed based on deep learning algorithms, which exhibited high accuracy in differentiating the MMD group from the HC group (AUC = 0.958, 95% CI of 0.911 to 1.000). Additionally, hierarchical clustering analysis revealed a significant association between SMFs across different groups and vascular cognitive impairment in MMD. This approach holds promise as a novel and intuitive diagnostic method for MMD. Furthermore, the study may have broader implications for the diagnosis of other neurological disorders.}, archive = {J_ADVS}, author = {Ruiyuan Weng and Yudian Xu and Xinjie Gao and Linlin Cao and Jiabin Su and Heng Yang and He Li and Chenhuan Ding and Jun Pu and Meng Zhang and Jiheng Hao and Wei Xu and Wei Ni and Kun Qian and Yuxiang Gu}, doi = {10.1002/advs.202405580}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2405580}, shortjournal = {Adv. Sci.}, title = {Non-invasive diagnosis of moyamoya disease using serum metabolic fingerprints and machine learning}, volume = {12}, year = {2025}, }
• (2025). Pathophysiology-directed engineering of a combination nanoanalgesic for neuropathic pain. ADVS, 12(8), 2405483. (www)

  @article{ , abstract = {Neuropathic pain, one of the most refractory pain diseases, remains a formidable medical challenge. There is still an unmet demand for effective and safe therapies to address this condition. Herein, a rat model of nerve injury-induced neuropathic pain is first established to explore its pathophysiological characteristics. Recognizing the role of neuroinflammation, an inflammation-resolving amphiphilic conjugate PPT is designed and synthesized by simultaneously conjugating polyethylene glycol, phenylboronic acid pinacol ester, and Tempol onto a cyclic scaffold. PPT can self-assemble into nanomicelles (termed PPTN). Following intravenous injection, PPTN preferentially accumulates in the injured nerve, ameliorates the neuroinflammatory milieu, and promotes nerve regeneration, thereby shortening neuropathic pain duration in rats. Moreover, the Ca 2+ channel α2δ1 subunit is identified as a therapeutic target by RNA-sequencing analysis of the injured nerve. Based on this target, a mimicking peptide (AD peptide) is screened as an analgesic. By packaging AD peptide into PPTN, a combination nano-analgesic APTN is developed. Besides potentiated anti-hyperalgesic effects due to site-specific delivery and on-demand release of AD peptide at target sites, APTN simultaneously inhibits neuroinflammation and promotes nerve regeneration by reprogramming macrophages via regulating MAPK/NF-kB signaling pathways and NLRP3 inflammasome activation, thus affording synergistic efficacies in treating nerve injury-induced neuropathic pain.}, archive = {J_ADVS}, author = {Wenkai Wang and Yan Wang and Xinle Huang and Peng Wu and Lanlan Li and Yang Zhang and Yihui Chen and Zhiyu Chen and Changqing Li and Yue Zhou and Jianxiang Zhang}, doi = {10.1002/advs.202405483}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2405483}, shortjournal = {Adv. Sci.}, title = {Pathophysiology-directed engineering of a combination nanoanalgesic for neuropathic pain}, volume = {12}, year = {2025}, }
• (2025). Loading of extracellular vesicles with nucleic acids via hybridization with non-lamellar liquid crystalline lipid nanoparticles. ADVS, 12(8), 2404860. (www)

  @article{ , abstract = {The translation of cell-derived extracellular vesicles (EVs) into biogenic gene delivery systems is limited by relatively inefficient loading strategies. In this work, the loading of various nucleic acids into small EVs via their spontaneous hybridization with preloaded non-lamellar liquid crystalline lipid nanoparticles (LCNPs), forming hybrid EVs (HEVs) is described. It is demonstrated that LCNPs undergo pH-dependent structural transitions from inverse hexagonal ( H II ) phases at pH 5 to more disordered non-lamellar phases, possibly inverse micellar ( L 2 ) or sponge ( L 3 ) phases, at pH 7.4, which are particularly suitable for inducing a controlled hybridization process with EVs. State-of-the-art single-particle analysis techniques reveal that LCNPs interact with various EV subpopulations at physiological conditions and that ≈40% of HEVs are loaded with the genetic cargo. Importantly, this study demonstrates that EV membrane proteins remain accessible on HEV surfaces, with their intrinsic enzymatic activity unaffected after the hybridization process. Finally, HEVs show in vitro improved transfection efficiencies compared to unhybridized LCNPs. In summary, this versatile platform holds potential for loading various nucleic acid molecules into native EVs and may help developing EV-based therapeutics.}, archive = {J_ADVS}, author = {Johannes Bader and Pascal Rüedi and Valeria Mantella and Silvana Geisshüsler and Finn Brigger and Bilal Muhammad Qureshi and Jaime Ortega Arroyo and Elita Montanari and Jean-Christophe Leroux}, doi = {10.1002/advs.202404860}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2404860}, shortjournal = {Adv. Sci.}, title = {Loading of extracellular vesicles with nucleic acids via hybridization with non-lamellar liquid crystalline lipid nanoparticles}, volume = {12}, year = {2025}, }
• (2025). Defluorinative cyclization of enamides with fluoroalkyl halides through two vicinal C(sp3)─F bonds functionalization. ADVS, 12(8), 2404738. (www)

  @article{ , abstract = {Introducing distinctive functional groups to expand the structural diversity and improve the intrinsic properties of parent molecules has been an essential pursuit in organic chemistry. By using perfluoroalkyl halide (PFAH) as a nontraditional, readily available, ideal 1,2-difluoroalkenyl coupling partner, a defluorinative cyclization reaction of enamides for the construction of fluoroalkenyl oxazoles is first developed. The selective and controllable two-fold cleavage of vicinal C(sp 3 )─F bonds in PFAH not only enables the introduction of a specific 1,2-difluoroalkenyl moiety with ease but also results in the functionalization of two C(sp 2 )─H bonds of enamides without the need for metal catalyst, photocatalyst, oxidant, or light. The method can be applied to the late-stage modification of complex molecules, synthesis of biological-relevant oxazole analoges, and scale-up synthesis, which all further highlight the real-world utility of this protocol. Mechanistic studies reveal that the reaction possibly proceeds through a radical perfluoroalkylation, consecutive C─F bond heterolytic cleavage, and cyclization process. In addition, the in situ formed perfluoroalkyl radical which may also serve as an essential hydrogen abstractor.}, archive = {J_ADVS}, author = {Yu-Lan Chen and Wei Han and Yuan-Yuan Ren and Mengtao Ma and Danhua Ge and Zhi-Liang Shen and Kai Guo and Xue-Qiang Chu}, doi = {10.1002/advs.202404738}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2404738}, shortjournal = {Adv. Sci.}, title = {Defluorinative cyclization of enamides with fluoroalkyl halides through two vicinal C(sp3)─F bonds functionalization}, volume = {12}, year = {2025}, }
• (2025). Rbfox3 promotes transformation of MDSC-like tumor cells to shape immunosuppressive microenvironment. ADVS, 12(8), 2404585. (www)

  @article{ , abstract = {Myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment (TME) contribute to the malignant progression of tumors by exerting immunosuppressive effects. Bacterial lipopolysaccharides (LPS) have been widely demonstrated in various types of solid tumors. LPS can promote the malignant progression of tumors, which mechanism has not yet been fully elucidated. In this study, a type of MDSC-like tumor cells (MLTCs) is found in tumor tissues induced by low-dose and long-term LPS stimulation. MLTCs can simultaneously express tumor cell and MDSCs markers. Similar to MDSCs, MLTCs can produce arginine, nitric oxide, and reactive oxygen species and inhibit the activity of NK and T cells to promote the formation of an immunosuppressive microenvironment. MLTCs can also promote tumor cell proliferation and vasculogenic mimicry formation. CRISPR-Cas9 activity screening studies identified RNA-binding Fox-1 homolog 3 (Rbfox3) as a critical protein for MLTCs formation after LPS treatment. Rbfox3 can transcriptionally regulate the expression of Ass1 in the form of phase-separated particles. Crocin can inhibit the generation of MLTCs by disrupting phase-separated particles of Rbfox3 and enhance the anti-tumor effects of immune checkpoint inhibitors (ICIs).}, archive = {J_ADVS}, author = {Zhiyang Li and Zhuangzhuang Feng and Mengzhan Chen and Xinxiu Shi and Bijia Cui and Yujie Sun and Heng Zhang and Yinan Li and Caihong Chen and Yiqian Feng and Jingxia Han and Xuewu Xing and Huijuan Liu and Tao Sun}, doi = {10.1002/advs.202404585}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2404585}, shortjournal = {Adv. Sci.}, title = {Rbfox3 promotes transformation of MDSC-like tumor cells to shape immunosuppressive microenvironment}, volume = {12}, year = {2025}, }
• (2025). Matrix-rigidity cooperates with biochemical cues in m2 macrophage activation through increased nuclear deformation and chromatin accessibility. ADVS, 12(8), 2403409. (www)

  @article{ , abstract = {Macrophages encounter a myriad of biochemical and mechanical stimuli across various tissues and pathological contexts. Notably, matrix rigidity has emerged as a pivotal regulator of macrophage activation through mechanotransduction. However, the precise mechanisms underlying the interplay between mechanical and biochemical cues within the nuclear milieu remain elusive. Here We elucidate how the increased matrix rigidity drives macrophages to amplify alternatively-activated (M2 phenotype) signaling cooperatively with biochemical cues (e.g., IL4/13) through altered nuclear mechanics. We demonstrate that reconstructed podosome-like F-actins and contractility induce nucleus deformation, opening nuclear pores, which facilitates nuclear translocation of the key transcription factor STAT6. Furthermore, the altered nuclear mechanics increases chromatin accessibility induced by H3K9 methylation, particularly of M2-associated gene promoters. These cooperative events of the mechano-chemical signaling at the cytoskeletal-to-nuclear domains facilitate M2 transcriptional activation and cellular functions. We further evidence the rigidity-primed M2 macrophages are immunosuppressive and accumulated within stiffened tumors in patients. This study proposes a mechanism by which matrix mechanics crosstalks with biochemical signals to potentiate macrophage activation through nuclear mechanosensing and chromatin modifications, offering insights into macrophage mechanobiology and its therapeutic modulations.}, archive = {J_ADVS}, author = {Seung Jae Shin and Buuvee Bayarkhangai and Khaliunsarnai Tsogtbaatar and Meng Yuxuan and Sang-Hyun Kim and Yong-Jae Kim and Ali Taghizadeh and Daesan Kim and Dong-Hwee Kim and Jung-Hwan Lee and Jeongeun Hyun and Hae-Won Kim}, doi = {10.1002/advs.202403409}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2403409}, shortjournal = {Adv. Sci.}, title = {Matrix-rigidity cooperates with biochemical cues in m2 macrophage activation through increased nuclear deformation and chromatin accessibility}, volume = {12}, year = {2025}, }
• (2025). A universal strategy of anti-tumor mRNA vaccine by harnessing “Off-the-shelf” immunity. ADVS, 12(8), 2401287. (www)

  @article{ , abstract = {Personalized neoantigen cancer mRNA vaccines are promising candidates for precision medicine. However, the difficulty of identifying neoantigens heavily hinders their broad applicability. This study developed a universal strategy of anti-tumor mRNA vaccine by harnessing “off-the-shelf” immunity to known antigens. First, the model antigen ovalbumin (OVA) is used for mRNA vaccine design. In vitro test indicated that this mRNA vaccine reprogrammed tumor cells that can be recognized and killed by OVA-specific cytotoxic T lymphocytes (CTLs). In situ mRNA vaccine notably inhibited tumor growth across three subcutaneous solid tumor models in mice. Further single-cell sequencing analyses revealed that mRNA vaccination act to reshape the immunosuppressive tumor microenvironment (TME) toward more proinflammatory characteristics. Strikingly, this framework of mRNA-based strategy can be applied to two clinical pathogen antigens, hepatitis B surface antigen (HBsAg), and SARS-CoV-2 spike receptor-binding domain (SRBD). Interestingly, the mRNA-based strategy largely recapitulated the scenario of spontaneous cancer regression following pathogen infection or vaccination. Collectively, this study provides not only proof of concept for universal anti-tumor mRNA therapy, but also mechanistic insights in echoing the long-standing puzzle of spontaneous cancer regression.}, archive = {J_ADVS}, author = {Jiayan Fu and Shuangqi Wu and Nengcheng Bao and Lili Wu and Huiru Qu and Zhechao Wang and Haiyang Dong and Jian Wu and Yongfeng Jin}, doi = {10.1002/advs.202401287}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2401287}, shortjournal = {Adv. Sci.}, title = {A universal strategy of anti-tumor mRNA vaccine by harnessing “Off-the-shelf” immunity}, volume = {12}, year = {2025}, }
• (2025). Mechanical force-induced cGAS activation in carcinoma cells facilitates splenocytes into liver to drive metastasis. ADVS, 12(8), 2401127. (www)

  @article{ , abstract = {Liver metastasis is the main cause of cancer-related mortality. During the metastasis process, circulating carcinoma cells hardly pass through narrow capillaries, leading to nuclear deformation. However, the effects of nuclear deformation and its underlying mechanisms on metastasis need further study. Here, it is shown that mechanical force-induced nuclear deformation exacerbates liver metastasis by activating the cGAS-STING pathway, which promotes splenocyte infiltration in the liver. Mechanical force results in nuclear deformation and rupture of the nuclear envelope with inevitable DNA leakage. Cytoplasmic DNA triggers the activation of cGAS-STING pathway, enhancing the production of IL6, TNFα, and CCL2. Additionally, splenocyte recruitment by the proinflammatory cytokines support carcinoma cell survival and colonization in the liver. Importantly, both intervening activity of cGAS and blocking of splenocyte migration to the liver efficiently ameliorate liver metastasis. Overall, these findings reveal a mechanism by which mechanical force-induced nuclear deformation exacerbates liver metastasis by regulating splenocyte infiltration into the liver and support targeting cGAS and blocking splenocyte recruitment as candidate therapeutic approaches for liver metastasis.}, archive = {J_ADVS}, author = {Xurui Zhang and Na Huang and Yanhua Mu and Haiyan Chen and Mengchen Zhu and Shaoying Zhang and Pengfei Liu and Hailong Zhang and Huan Deng and Keping Feng and Qi Shang and Xi Liu and Chen Zhang and Mengjiao Shi and Lan Yang and Jin Sun and Guangyao Kong and Jing Geng and Shemin Lu and Zongfang Li}, doi = {10.1002/advs.202401127}, journal = {Advanced Science}, month = {2}, number = {8}, pages = {2401127}, shortjournal = {Adv. Sci.}, title = {Mechanical force-induced cGAS activation in carcinoma cells facilitates splenocytes into liver to drive metastasis}, volume = {12}, year = {2025}, }
• (2025). Spin excitations of high spin Iron(II) in Metal–Organic chains on metal and superconductor (Adv. sci. 7/2025). ADVS, 12(7), 2570043. (www)

  @article{ , archive = {J_ADVS}, author = {Jung-Ching Liu and Chao Li and Outhmane Chahib and Xing Wang and Simon Rothenbühler and Robert Häner and Silvio Decurtins and Ulrich Aschauer and Shi-Xia Liu and Ernst Meyer and Rémy Pawlak}, doi = {10.1002/advs.202570043}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2570043}, shortjournal = {Adv. Sci.}, title = {Spin excitations of high spin Iron(II) in Metal–Organic chains on metal and superconductor (Adv. sci. 7/2025)}, volume = {12}, year = {2025}, }
• (2025). Support-free, connected Core–Shell nanoparticle catalysts synthesized via a low-temperature process for advanced oxygen reduction performance (Adv. sci. 7/2025). ADVS, 12(7), 2570042. (www)

  @article{ , archive = {J_ADVS}, author = {Aparna Chitra Sudheer and Gopinathan M. Anilkumar and Hidenori Kuroki and Takeo Yamaguchi}, doi = {10.1002/advs.202570042}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2570042}, shortjournal = {Adv. Sci.}, title = {Support-free, connected Core–Shell nanoparticle catalysts synthesized via a low-temperature process for advanced oxygen reduction performance (Adv. sci. 7/2025)}, volume = {12}, year = {2025}, }
• (2025). Robotic laser tissue soldering for atraumatic soft tissue fusion guided by fluorescent nanothermometry (Adv. sci. 7/2025). ADVS, 12(7), 2570040. (www)

  @article{ , archive = {J_ADVS}, author = {Oscar Cipolato and Tobias Leuthold and Marius Zäch and Georg Männel and Sam Aegerter and Calinda Sciascia and Alexander Jessernig and Marco von Salis and Sima Sarcevic and Jachym Rosendorf and Vaclav Liska and Dennis Kundrat and Romain Quidant and Inge K. Herrmann}, doi = {10.1002/advs.202570040}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2570040}, shortjournal = {Adv. Sci.}, title = {Robotic laser tissue soldering for atraumatic soft tissue fusion guided by fluorescent nanothermometry (Adv. sci. 7/2025)}, volume = {12}, year = {2025}, }
• (2025). An artificial neural network for image classification inspired by the aversive olfactory learning neural circuit in caenorhabditis elegans (Adv. sci. 7/2025). ADVS, 12(7), 2570039. (www)

  @article{ , archive = {J_ADVS}, author = {Xuebin Wang and Chunxiuzi Liu and Meng Zhao and Ke Zhang and Zengru Di and He Liu}, doi = {10.1002/advs.202570039}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2570039}, shortjournal = {Adv. Sci.}, title = {An artificial neural network for image classification inspired by the aversive olfactory learning neural circuit in caenorhabditis elegans (Adv. sci. 7/2025)}, volume = {12}, year = {2025}, }
• (2025). Berberine derivative b68 promotes tumor immune clearance by dual-targeting BMI1 for senescence induction and CSN5 for PD-l1 degradation (Adv. sci. 7/2025). ADVS, 12(7), 2570038. (www)

  @article{ , archive = {J_ADVS}, author = {Hongmei Hu and Qun Wang and Dianping Yu and Xiaoyu Tao and Mengmeng Guo and Saisai Tian and Qing Zhang and Mengting Xu and Xiangxin Geng and Hongwei Zhang and Hanchi Xu and Linyang Li and Shize Xie and Kaixian Chen and Weiliang Zhu and Xu-Wen Li and Hanchen Xu and Bo Li and Weidong Zhang and Sanhong Liu}, doi = {10.1002/advs.202570038}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2570038}, shortjournal = {Adv. Sci.}, title = {Berberine derivative b68 promotes tumor immune clearance by dual-targeting BMI1 for senescence induction and CSN5 for PD-l1 degradation (Adv. sci. 7/2025)}, volume = {12}, year = {2025}, }
• (2025). Microglia process α-synuclein fibrils and enhance their pathogenicity in a TREM2-dependent manner (Adv. sci. 7/2025). ADVS, 12(7), 2570037. (www)

  @article{ , archive = {J_ADVS}, author = {Min Xiong and Danhao Xia and Honglu Yu and Lanxia Meng and Xingyu Zhang and Jiehui Chen and Ye Tian and Xin Yuan and Xuan Niu and Shuke Nie and Zhaohui Zhang and Chaoyang Liu and Qiang Chen and Keqiang Ye and Zhentao Zhang}, doi = {10.1002/advs.202570037}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2570037}, shortjournal = {Adv. Sci.}, title = {Microglia process α-synuclein fibrils and enhance their pathogenicity in a TREM2-dependent manner (Adv. sci. 7/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “ECM-inspired hydrogels with ADSCs encapsulation for rheumatoid arthritis treatment”. ADVS, 12(7), 2417661. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202417661}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2417661}, shortjournal = {Adv. Sci.}, title = {Correction to “ECM-inspired hydrogels with ADSCs encapsulation for rheumatoid arthritis treatment”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Molecular determinant underlying selective coupling of primary G-protein by class a GPCRs”. ADVS, 12(7), 2416290. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202416290}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2416290}, shortjournal = {Adv. Sci.}, title = {Correction to “Molecular determinant underlying selective coupling of primary G-protein by class a GPCRs”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Wheel-running exercise alleviates anxiety-like behavior via down-regulating S-nitrosylation of gephyrin in the basolateral amygdala of male rats”. ADVS, 12(7), 2415925. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202415925}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2415925}, shortjournal = {Adv. Sci.}, title = {Correction to “Wheel-running exercise alleviates anxiety-like behavior via down-regulating S-nitrosylation of gephyrin in the basolateral amygdala of male rats”}, volume = {12}, year = {2025}, }
• (2025). A synergistic dual-atom sites nanozyme augments immunogenic cell death for efficient immunotherapy. ADVS, 12(7), 2414734. (www)

  @article{ , abstract = {Inducing immunogenic cell death (ICD) is a promising approach to elicit enduring antitumor immune responses. Hence, extensive efforts are being made to develop ICD inducers. Herein, a cascaded dual-atom nanozyme with Fe and Cu sites (FeCu-DA) as an efficient ICD inducer is presented. The Fe and Cu dual-atom sites synergistically enhance peroxidase (POD) and catalase activities, effectively converting intratumoral hydrogen peroxide (H 2 O 2 ) to hydroxyl radicals (·OH) and oxygen (O 2 ). Moreover, FeCu-DA exhibits superior glutathione-oxidase (GSH-OXD) activity, catalyzing GSH oxidation to generate H 2 O 2 , enabling cascaded catalysis for sustainable ∙OH generation and reducing reactive oxygen species (ROS) resistance by consuming GSH. Steady–state kinetic analysis and density functional theory calculations indicate that FeCu-DA exhibits a higher catalytic rate and efficiency than Fe single-atom nanozymes (Fe-SA) because of its stronger interactions with H 2 O 2 . Its POD activity is 948.05 U mg −1 , which is 2.8-fold greater than that of Fe-SA. Furthermore, FeCu-DA exhibits impressive photothermal effects and photothermal-enhanced cascaded catalysis kinetics for ROS generation, thereby inducing potent ICD. Combined with anti-PD-L1 antibody (αPD-L1) blockade, FeCu-DA shows synergistic enhancement in treatment under near-infrared irradiation. This study provides insights for designing efficient dual-atom nanozymes and demonstrates their potential in ICD-induced cancer immunotherapy.}, archive = {J_ADVS}, author = {Shipeng Ning and Zeyuan Zhang and Yujing Ren and Yaxin Hou and Dan Li and Jingqi Chen and Yujie Zhai and Kelong Fan and Weiqing Zhang}, doi = {10.1002/advs.202414734}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2414734}, shortjournal = {Adv. Sci.}, title = {A synergistic dual-atom sites nanozyme augments immunogenic cell death for efficient immunotherapy}, volume = {12}, year = {2025}, }
• (2025). MicroRNA gets a mighty award. ADVS, 12(7), 2414625. (www)

  @article{ , abstract = {Recent advancements in microRNAs (miRNAs) research have revealed their key roles in both normal physiological processes and pathological conditions, leading to potential applications in diagnostics and therapeutics. However, the path forward is fraught with several scientific and technical challenges. This review article briefly explores the milestones of the discovery, biogenesis, functions, and application for clinical diagnostic and therapeutic strategies of miRNAs. The potential challenges and future directions are also discussed to fully harness their capabilities.}, archive = {J_ADVS}, author = {Yu Li and Sijie Chen and Hai Rao and Shengjin Cui and Guoan Chen}, doi = {10.1002/advs.202414625}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2414625}, shortjournal = {Adv. Sci.}, title = {MicroRNA gets a mighty award}, volume = {12}, year = {2025}, }
• (2025). Nerve growth factor signaling promotes nuclear translocation of TRAF4 to enhance tumor stemness and metastatic dormancy via C-jun-mediated IL-8 autocrine. ADVS, 12(7), 2414437. (www)

  @article{ , abstract = {Tumor necrosis factor receptor-associated factor 4 (TRAF4), an E3 ubiquitin ligase, is frequently overexpressed in tumors. Although its cytoplasmic role in tumor progression is well-documented, the precise mechanisms underlying its nuclear localization and functional contributions in tumor cells remain elusive. This study demonstrated a positive correlation between the expression of nuclear TRAF4 and both tumor grades and stemness signatures in human cancer tissues. Notably, reduced nuclear TRAF4 led to decreased stemness properties and metastatic dormancy of tumor cells. Conversely, restoring nuclear TRAF4 in TRAF4-knockout (TRAF4-KO) cells augmented these cellular capabilities. Within the nucleus, the TRAF domain of TRAF4 interacted with c-Jun, thereby stimulating its transcriptional activity. This interaction subsequently led to an enhancement of the promoter activity of interleukin-8 (IL-8), which is identified as a mediator of nuclear TRAF4-induced tumor dormancy. Additionally, activation of AKT signaling by nerve growth factor facilitated TRAF4 phosphorylation at Ser242, enhancing its interaction with 14-3-3θ and promoting its nuclear translocation. Importantly, pharmacological modulation of TRAF4 nuclear translocation is found to suppress tumor tumorigenicity and metastasis in tumor models. This study highlights the critical role of nuclear TRAF4 in regulating tumor stemness and dormancy, positioning it as a potential therapeutic target for metastatic and refractory cancers.}, archive = {J_ADVS}, author = {Kai Zhao and Tifan Sun and Qiruo Sun and Zhenzhong Chen and Tiepeng Wang and Jinming Yang and Lei Li and Yanan Zhu and Xinye Liu and Dawei Yang and Binyan Lin and Na Lu}, doi = {10.1002/advs.202414437}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2414437}, shortjournal = {Adv. Sci.}, title = {Nerve growth factor signaling promotes nuclear translocation of TRAF4 to enhance tumor stemness and metastatic dormancy via C-jun-mediated IL-8 autocrine}, volume = {12}, year = {2025}, }
• (2025). Stable and lead-free perovskite hemispherical photodetector for vivid fourier imaging. ADVS, 12(7), 2414430. (www)

  @article{ , abstract = {The filterless single-pixel imaging technology is anticipated to hold tremendous competitiveness in diverse imaging applications. Nevertheless, achieving single-pixel color imaging without a filter remains a formidable challenge. Here a lead-free perovskite hemispherical photodetector is reported for filterless single-pixel color imaging. Through passivating the active vacancy and antisite defects with functional chemical groups, the trap density of the perovskite film can be dramatically reduced to half of the pristine one, which results in a stable device with 0.69 nA standard deviation (SD) of the current fluctuations for over 10 000 s. The exceptional stability and remarkable low light response capability of passivated lead-free perovskite devices ensure reliable and repeated distinguishment to high-frequency color information of Fourier patterns. High-resolution color imaging with 256 × 256 pixels can be achieved by integrating the Bayer template with Fourier patterns and designing a corresponding color restoration algorithm. Notably, its imaging quality surpasses commercial silicon photomultiplier tubes (SiPMs) under low light intensities or high-temperature conditions as demonstrated by the larger signal-to-noise ratio (SNR). This work presents a novel approach for applying perovskite photodetectors in single-pixel color imaging, propelling the advancement of filterless color imaging technology.}, archive = {J_ADVS}, author = {Chenglong Li and Weijun Li and Wei Qu and Haijing Hu and Jia Zong and Haotong Wei}, doi = {10.1002/advs.202414430}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2414430}, shortjournal = {Adv. Sci.}, title = {Stable and lead-free perovskite hemispherical photodetector for vivid fourier imaging}, volume = {12}, year = {2025}, }
• (2025). Triple-combination therapy with a multifunctional Yolk–Shell nanozyme Au@CeO2 loaded with dimethyl fumarate for periodontitis. ADVS, 12(7), 2413891. (www)

  @article{ , abstract = {Periodontitis, a chronic inflammatory disease, is the leading cause of tooth loss in adults and is one of the most prevalent and complex oral conditions. Oxidative stress induced by the excessive generation of reactive oxygen species (ROS) leads to periodontitis, which is closely associated with pathological processes, including mitochondrial dysfunction of periodontal cells and local immune dysregulation. However, current treatment modalities that target single pathological processes have limited long-term therapeutic effects. Herein, a multifunctional Yolk–Shell nanozyme, Au@CeO 2 -dimethyl fumarate (DMF), which comprehensively addresses the oxidative stress-induced pathophysiological processes of periodontitis through antioxidant activity, mitochondrial maintenance, and immune modulation mechanisms, is described. For material design logic, functionally complementary Au and CeO 2 formed an excellent photothermally regulated high-efficiency nanozyme, which also provided an ideal drug carrier for DMF. As for the therapeutic logic, Au@CeO 2 -DMF restores mitochondrial dysfunction and immune dysregulation, which also contributes to endogenous ROS elimination, thereby achieving long-term stable therapeutic effects. In a rat model, local Au@CeO 2 -DMF photothermal therapy effectively alleviated ROS-induced tissue damage and restored periodontal homeostasis. Altogether, this study presents a novel antioxidant nanozyme for managing alveolar bone loss under prolonged oxidative stress and demonstrates the importance of comprehensive intervention in key pathological processes in periodontitis treatment design.}, archive = {J_ADVS}, author = {Tiancheng Li and Mengmeng Shu and Cheng Zhu and Qicheng Liu and Yixin Li and Ruike Wang and Lihan Chen and Wenxiao Shi and Zhaoxuan Sun and Zhiyao Hou and Bing Fang and Lunguo Xia}, doi = {10.1002/advs.202413891}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413891}, shortjournal = {Adv. Sci.}, title = {Triple-combination therapy with a multifunctional Yolk–Shell nanozyme Au@CeO2 loaded with dimethyl fumarate for periodontitis}, volume = {12}, year = {2025}, }
• (2025). Artificial control of giant converse magnetoelectric effect in spintronic multiferroic heterostructure. ADVS, 12(7), 2413566. (www)

  @article{ , abstract = {To develop voltage-controlled magnetization switching technologies for spintronics applications, a highly (422)-oriented Co 2 FeSi layer on top of the piezoelectric PMN-PT(011) is experimentally demonstrated by inserting a vanadium (V) ultra-thin layer. The strength of the growth-induced magnetic anisotropy of the (422)-oriented Co 2 FeSi layers can be artificially controlled by tuning the thicknesses of the inserted V and the grown Co 2 FeSi layers. As a result, a giant converse magnetoelectric effect (over 10 −5 s m −1 ) and a non-volatile binary state at zero electric field are simultaneously achieved in the (422)-oriented Co 2 FeSi/V/PMN-PT(011) multiferroic heterostructure. This study leads to a way toward magnetoresistive random-access-memory (MRAM) with a low power writing technology.}, archive = {J_ADVS}, author = {Takamasa Usami and Yuya Sanada and Shumpei Fujii and Shinya Yamada and Yu Shiratsuchi and Ryoichi Nakatani and Kohei Hamaya}, doi = {10.1002/advs.202413566}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413566}, shortjournal = {Adv. Sci.}, title = {Artificial control of giant converse magnetoelectric effect in spintronic multiferroic heterostructure}, volume = {12}, year = {2025}, }
• (2025). FGF19-activated hepatic stellate cells release ANGPTL4 that promotes colorectal cancer liver metastasis. ADVS, 12(7), 2413525. (www)

  @article{ , abstract = {Liver and lung are the most common metastatic sites in colorectal cancer (CRC), where the tumor microenvironment (TME) plays a crucial role in the progression and metastasis of CRC. Understanding the interactions between various types of cells in the TME can suggest innovative therapeutic strategies. Using single-cell RNA sequencing (scRNA-Seq) and clinical samples, fibroblast growth factor-19 (FGF19, rodent FGF15) is found to mediate a significant interaction between CRC cells and cancer-associated fibroblasts (CAFs), activating the hepatic stellate cells (HSCs)-to-CAFs differentiation. In various CRC metastatic mouse models, it is shown that FGF15 has a more pronounced effect on liver metastasis compared to pulmonary metastasis. More importantly, the differentially expressed genes (DEGs) are also identified from the RNA-Seq dataset upon the activation of HSCs by FGF19 and compared the DEGs in matched primary and metastatic mRNA samples from patients with CRC liver metastasis (CRCLM), it is found that the ANGPTL4 gene is significantly associated with HSCs activation. Different mouse models also demonstrated the impact of the FGF19/ANGPTL4 axis on the severity of CRCLM. Importantly, disruption of this axis significantly inhibits CRCLM in vivo. This study is among the first to demonstrate the impact of the FGF19/ANGPTL4 axis on CRCLM, offering a novel therapeutic strategy.}, archive = {J_ADVS}, author = {Xueying Fan and Baoting Li and Fan Zhang and Meng Liu and Hiu-Yee Kwan and Zhongqiu Liu and Tao Su}, doi = {10.1002/advs.202413525}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413525}, shortjournal = {Adv. Sci.}, title = {FGF19-activated hepatic stellate cells release ANGPTL4 that promotes colorectal cancer liver metastasis}, volume = {12}, year = {2025}, }
• (2025). Targeting CDK2 confers vulnerability to lenvatinib via driving senescence in anaplastic thyroid cancer. ADVS, 12(7), 2413514. (www)

  @article{ , abstract = {Anaplastic thyroid cancer (ATC) is the most lethal tumor arising from thyroid follicular epithelium. Lenvatinib is an off-label use option for ATC patients in many countries but an approved prescription in Japan. However, lenvatinib resistance is a substantial clinical challenge. Clinical ATC samples including lenvatinib-resistant tumors are used to build patient-derived cells and patient-derived xenografts. High-throughput drug screening and synergy analyses are performed to identify an effective combination partner for lenvatinib. Cellular functions are detected by cell senescence, apoptosis, cell cycle, cell viability and colony formation assays. CDK2 inhibition showed the significant synthetic lethality with lenvatinib via inhibiting G1/S transition and inducing cell senescence in ATC. High expression of CDK2 is associated with lenvatinib resistance and poor clinical outcomes of ATC patients. Lenvatinib increased protein expression of CDK2 in lenvatinib-resistant ATC cells. Mechanistically, lenvatinib inhibited protein degradation of CDK2 via reducing CDK2's interaction with the RACK1-FBW7 complex, which is involved in ubiquitination and subsequent proteasomal degradation of CDK2. Combination of CDK2 inhibitors in clinical trials (Dinaciclib or PF-07104091) and lenvatinib markedly suppressed growth of xenograft tumors from the lenvatinib-resistant patient. The findings support the combination therapy strategy of lenvatinib and CDK2 inhibitor for lenvatinib-resistant ATC patients with high CDK2 expression.}, archive = {J_ADVS}, author = {Ben Ma and Youzhou Sang and Xiaoxue Du and Yanzhi Zhang and Min Yin and Weibo Xu and Wanlin Liu and Jiayi Lu and Qing Guan and Yunjun Wang and Tian Liao and Yuting Wang and Jun Xiang and Rongliang Shi and Ning Qu and Qinghai Ji and Jiwei Zhang and Dongmei Ji and Yu Wang}, doi = {10.1002/advs.202413514}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413514}, shortjournal = {Adv. Sci.}, title = {Targeting CDK2 confers vulnerability to lenvatinib via driving senescence in anaplastic thyroid cancer}, volume = {12}, year = {2025}, }
• (2025). Microglia process α-synuclein fibrils and enhance their pathogenicity in a TREM2-dependent manner. ADVS, 12(7), 2413451. (www)

  @article{ , abstract = {Parkinson's disease (PD) is characterized by the deposition of misfolded α-synuclein (α-syn) in the brain. Converging evidence indicates that the intracellular transmission and subsequent templated amplification of α-syn are involved in the onset and progression of PD. However, the molecular mechanisms underlying the cell-to-cell transmission of pathological α-syn remain poorly understood. Microglia is highly activated in the brains of PD patients. Here, it is shown that depletion of microglia slows the spread of pathological α-syn pathology in mice injected with α-syn fibrils. Microglia phagocytose α-syn fibrils and transform them into more toxic species. The phagocytosis of α-syn fibrils by microglia is partially mediated by triggering a receptor expressed on myeloid cells 2 (TREM2), a transmembrane protein expressed on the surface of microglia. The endocytosed α-syn fibrils are then cleaved by the lysosomal proteinase asparagine endopeptidase (AEP) to generate truncated α-syn 1–103 fibrils with enhanced seeding activity. Knockout of TREM2 and AEP impedes the endocytosis and cleavage of α-syn fibrils, respectively. The results demonstrate that TREM2-mediated phagocytosis of α-syn fibrils by microglia and subsequent AEP-mediated cleavage of α-syn fibrils contribute to the spread of α-syn in the brain. Blocking either of these two steps attenuates the progression of α-syn pathology.}, archive = {J_ADVS}, author = {Min Xiong and Danhao Xia and Honglu Yu and Lanxia Meng and Xingyu Zhang and Jiehui Chen and Ye Tian and Xin Yuan and Xuan Niu and Shuke Nie and Zhaohui Zhang and Chaoyang Liu and Qiang Chen and Keqiang Ye and Zhentao Zhang}, doi = {10.1002/advs.202413451}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413451}, shortjournal = {Adv. Sci.}, title = {Microglia process α-synuclein fibrils and enhance their pathogenicity in a TREM2-dependent manner}, volume = {12}, year = {2025}, }
• (2025). Hyper-thick electrodes for lithium-ion batteries enabled by micro-electric-field process. ADVS, 12(7), 2413444. (www)

  @article{ , abstract = {Increasing electrode thickness is a key strategy to boost energy density in lithium-ion batteries (LIBs), which is essential for electric vehicles and energy storage applications. However, thick electrodes face significant challenges, including poor ion transport, long diffusion paths, and mechanical instability, all of which degrade battery performance. To overcome these barriers, a novel micro-electric-field (μ-EF) process is introduced that enhances particle alignment during fabrication with reduced distance between anode and cathode. This process produces hyper-thick (≈700 µm) electrodes with low tortuosity and improved ion diffusion. The μ-EF electrodes achieve high areal capacities (≈8 mAh cm −2 ), while maintaining power density and long cycle life. The electrodes show stable performance under high C-rate cycling and retain structural integrity after 1000 cycles at 2 C. By offering a scalable solution to the challenges of thick electrode fabrication, the μ-EF process represents a significant advancement for high-capacity LIBs in electric vehicles and energy storage systems.}, archive = {J_ADVS}, author = {Tazdik Patwary Plateau and Gracie Boyer and Jonghyun Park}, doi = {10.1002/advs.202413444}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413444}, shortjournal = {Adv. Sci.}, title = {Hyper-thick electrodes for lithium-ion batteries enabled by micro-electric-field process}, volume = {12}, year = {2025}, }
• (2025). Harnessing the TAF1 acetyltransferase for targeted acetylation of the tumor suppressor p53. ADVS, 12(7), 2413377. (www)

  @article{ , abstract = {Pharmacological reactivation of the tumor suppressor p53 remains a key challenge for the treatment of cancer. Ace tylation Ta rgeting C himera (AceTAC), a novel technology is previously reported that hijacks lysine acetyltransferases p300/CBP to acetylate the p53Y220C mutant. However, p300/CBP are the only acetyltransferases harnessed for AceTAC development to date. In this study, it is demonstrated for the first time that the TAF1 acetyltransferase can be recruited to acetylate p53Y220C. A novel TAF1-recruiting AceTAC, MS172 is discovered, which effectively acetylates p53Y220C lysine 382 in a concentration-, time- and TAF1-dependent manner via inducing the ternary complex formation between p53Y220C and TAF1. Notably, MS172 suppresses the proliferation in multiple p53Y220C-harboring cancer cell lines more potently than the previously reported p300/CBP-recruiting p53Y220C AceTAC MS78 with little toxicity in p53 WT and normal cells. Additionally, MS172 is bioavailable in mice and suitable for in vivo efficacy studies. Lastly, novel upregulation of metallothionine proteins by MS172-induced p53Y220C acetylation is discovered using RNA-seq and RT-qPCR studies. This work demonstrates that TAF1 can be harnessed for AceTAC development and expands the very limited repertoire of the acetyltransferases that can be leveraged for developing AceTACs, thus advancing the targeted protein acetylation field.}, archive = {J_ADVS}, author = {Md Kabir and Xiaoping Hu and Tiphaine C. Martin and Dmitry Pokushalov and Yong Joon Kim and Yiyang Chen and Yue Zhong and Qiong Wu and Jerry E. Chipuk and Yi Shi and Yan Xiong and Wei Gu and Ramon E. Parsons and Jian Jin}, doi = {10.1002/advs.202413377}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413377}, shortjournal = {Adv. Sci.}, title = {Harnessing the TAF1 acetyltransferase for targeted acetylation of the tumor suppressor p53}, volume = {12}, year = {2025}, }
• (2025). The current advances in design strategy (Indirect strategy and direct strategy) for type-I photosensitizers. ADVS, 12(7), 2413365. (www)

  @article{ , abstract = {Type-I photosensitizers (PSs) are among the most potential candidates for photodynamic therapy (PDT), as their low dependence on oxygen endow them with many advantages for treating hypoxic tumor. However, most of the reported type-I PSs have a contingency of molecular design, because electron transfer (ET) reaction is more difficult to achieve than energy transfer (EET) process. Therefore, it is urgent to understand molecular design mechanisms for type-I PSs. In this review, the two ways to achieve the type-I PSs, i.e., inhibiting EET process (type-II) or enhancing ET process (type-I), are detailly explained. In response, the current design strategies of type-I PSs are summarized from two perspectives: indirect strategy (inhibiting EET process: reducing the energy of the lowest triplet excited state (T 1 ) to lower than the energy required for the excitation energy transfer to produce singlet oxygen) and direct strategy (enhancing ET process: promoting the ET efficiency of PSs to generate superoxide radicals). The construction of direct strategy can be realized by forming an electron-rich microenvironment, providing an electron-deficient intermediate transmitter, and introducing an enhanced electron transfer capacity primitive.}, archive = {J_ADVS}, author = {Ning Ma and Junjie Wang and Hui Tang and Shiyu Wu and Xiaochun Liu and Kangyao Chen and Yahui Zhang and Xiaoqi Yu}, doi = {10.1002/advs.202413365}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413365}, shortjournal = {Adv. Sci.}, title = {The current advances in design strategy (Indirect strategy and direct strategy) for type-I photosensitizers}, volume = {12}, year = {2025}, }
• (2025). Interface-driven catalytic enhancements in nitrogen-doped carbon immobilized CoNi2S4@ReS2/CC heterostructures for optimized hydrogen and oxygen evolution in alkaline seawater-splitting. ADVS, 12(7), 2413245. (www)

  @article{ , abstract = {The rational design of multicomponent heterostructure is an effective strategy to enhance the catalytic activity of electrocatalysts for water and seawater electrolysis in alkaline conditions. Herein, MOF-derived nitrogen-doped carbon/nickel-cobalt sulfides coupled vertically aligned Rhenium disulfide (ReS 2 ) on carbon cloth (NC-CoNi 2 S 4 @ReS 2 /CC) are constructed via hydrothermal and activation approaches. Experimental and theoretical analysis demonstrates that the strong interactions between multiple interfaces promote electron redistribution and facilitate water dissociation, thereby optimizing *H adsorption energy for the hydrogen evolution reaction (HER). Meanwhile, the adsorption energies of oxygenated intermediates are balanced to reduce the thermodynamic barrier for the oxygen evolution reaction (OER). Consequently, NC-CoNi 2 S 4 @ReS 2 /CC shows smaller overpotentials of 87 and 253 mV for HER and OER at 10 mA cm −2 , with a lower Tafel slope and R ct than control samples. Superior catalytic stability is confirmed by cyclic voltammetry (CV) for 1000 cycles and CA test for 56 h. Furthermore, NC-CoNi 2 S 4 @ReS 2 /CC presents exceptional electrocatalytic activity in both alkaline water/seawater electrolytes. Stability assessments reveal that NC-CoNi 2 S 4 @ReS 2 /CC maintains a highly catalytic activity in both water and seawater, owing to the corrosion-resistant properties of the sulfur species at the interface. These findings highlight the importance of designing heterostructure electrocatalysts for clean hydrogen production.}, archive = {J_ADVS}, author = {Yanhui Lu and Zhengqiang Zhao and Xiaotong Liu and Xu Yu and Wenqiang Li and Chengang Pei and Ho Seok Park and Jung Kyu Kim and Huan Pang}, doi = {10.1002/advs.202413245}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413245}, shortjournal = {Adv. Sci.}, title = {Interface-driven catalytic enhancements in nitrogen-doped carbon immobilized CoNi2S4@ReS2/CC heterostructures for optimized hydrogen and oxygen evolution in alkaline seawater-splitting}, volume = {12}, year = {2025}, }
• (2025). High-performance boiling surfaces enabled by an electrode-transpose all-electrochemical strategy. ADVS, 12(7), 2413142. (www)

  @article{ , abstract = {High-performance boiling surfaces are in great demand for efficient cooling of high-heat-flux devices. Although various micro-/nano-structured surfaces have been engineered toward higher surface wettability and wickability for enhanced boiling, the design and fabrication of surface structures for realizing both high critical heat flux (CHF) and high heat transfer coefficient (HTC) remain a key challenge. Here, a novel “electrode-transpose” all-electrochemical strategy is proposed to create superhydrophilic microporous surfaces with higher dendrites and larger pores by simply adding an electrochemical etching step prior to the multiple electrochemical deposition steps. Enabled by the high nucleation density and high wicking capability, a high boiling performance is shown on such “etching-then-deposition” surfaces with simultaneously high CHF of 2,641 ± 10 kW m −2 and high HTC of 214 ± 6 kW (m 2 K) −1 , which are more than 2.5 and 4.3-fold enhanced from those on smooth surfaces, respectively. A very stable morphology and boiling performance of such surfaces subject to consecutive tests are also shown. Using this strategy, such superhydrophilic microporous layers are fabricated on curved surfaces with larger areas, both on spheres and slender cylinders, and demonstrate excellent boiling performance in quenching tests. This facile, geometry-adaptive, durable, and scalable strategy is very promising for making high-performance boiling surfaces for large-scale industrial applications.}, archive = {J_ADVS}, author = {Yu-Ming Chen and Nan Hu and Jia-Yi Zhang and Yi-Fei Sun and Yue-Fei Wu and Zi-Rui Li and Li-Wu Fan}, doi = {10.1002/advs.202413142}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413142}, shortjournal = {Adv. Sci.}, title = {High-performance boiling surfaces enabled by an electrode-transpose all-electrochemical strategy}, volume = {12}, year = {2025}, }
• (2025). Berberine derivative b68 promotes tumor immune clearance by dual-targeting BMI1 for senescence induction and CSN5 for PD-l1 degradation. ADVS, 12(7), 2413122. (www)

  @article{ , abstract = {Promoting tumor cell senescence arrests the cell cycle of tumor cells and activates the immune system to eliminate these senescent cells, thereby suppressing tumor growth. Nevertheless, PD-L1 positive senescent tumor cells resist immune clearance and possess the ability to secret various cytokines and inflammatory factors that stimulate the growth of tumor cells. Consequently, drugs capable of both triggering senescence in tumor cells and concurrently diminishing the expression of PD-L1 to counteract immune evasion are urgently needed. Here, a berberine derivative B68 is developed, which specifically induces tumor cell senescence by targeting BMI1. B68 also involves the degradation of PD-L1 by targeting CSN5, thereby disrupting the immunosuppressive PD-1/PD-L1 interaction and enabling rapid clearance of senescent tumor cells. This approach simultaneously inhibits tumor progression and activates T cell immunity, as evidenced by the robust antitumor response following B68-induced immunization of senescent cancer cells. Moreover, the synergistic effect of B68 with anti-CTLA4 therapy further enhances antitumor immunity, and its ability to induce senescence in cancer cells triggers a strong protective response by dendritic and CD8 + T cells. These findings provide a scientific basis for developing a new tumor treatment strategy based on senescence induction and lay the foundation for further preclinical research.}, archive = {J_ADVS}, author = {Hongmei Hu and Qun Wang and Dianping Yu and Xiaoyu Tao and Mengmeng Guo and Saisai Tian and Qing Zhang and Mengting Xu and Xiangxin Geng and Hongwei Zhang and Hanchi Xu and Linyang Li and Shize Xie and Kaixian Chen and Weiliang Zhu and Xu-Wen Li and Hanchen Xu and Bo Li and Weidong Zhang and Sanhong Liu}, doi = {10.1002/advs.202413122}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413122}, shortjournal = {Adv. Sci.}, title = {Berberine derivative b68 promotes tumor immune clearance by dual-targeting BMI1 for senescence induction and CSN5 for PD-l1 degradation}, volume = {12}, year = {2025}, }
• (2025). A microtubule-associated protein functions in preventing oocytes from evading the spindle assembly checkpoint. ADVS, 12(7), 2413097. (www)

  @article{ , abstract = {Aneuploidy eggs are a common cause of human infertility, spontaneous abortion, or trisomy syndromes. The spindle assembly checkpoint (SAC) plays a crucial role in preventing aneuploidy in oocytes, yet it is unclear if additional mechanisms exist to ensure oocyte adherence to this checkpoint. It is now revealed that the microtubule-associated protein NUSAP can prevent oocytes from evading the SAC and regulate the speed of the cell cycle. Mechanistically, the study identifies NUSAP as a novel stabilizer of the E3 ubiquitin ligase APC/C CDH1 , protecting CDH1 from SCF BTRC -mediated degradation. Depletion of NUSAP reduces CDH1 protein level, leading to abnormal spindle assembly and chromosome alignment, and disrupting the balance of cell cycle proteins. This misregulated balance causes oocytes to evade the SAC. Consequently, these abnormal oocytes not only fail to arrest at metaphase but also accelerate the cell process, ultimately resulting in the production of aneuploid eggs. Together, the findings not only clarify the existence of mechanisms that ensure oocytes compliance with the spindle assembly checkpoint but also expand the new functions of NUSAP beyond its role as a microtubule- associated protein.}, archive = {J_ADVS}, author = {Changyin Zhou and Xue Zhang and Genlu Xu and Yuting Ran and Hui Wang and Xuefeng Xie and Ang Li and Fei Li and Xiaozhen Li and Jinlong Ding and Mianqun Zhang and Qing-Yuan Sun and Xiang-Hong Ou}, doi = {10.1002/advs.202413097}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413097}, shortjournal = {Adv. Sci.}, title = {A microtubule-associated protein functions in preventing oocytes from evading the spindle assembly checkpoint}, volume = {12}, year = {2025}, }
• (2025). Novel insights into enhanced stability of li-rich layered and high-voltage olivine phosphate cathodes for advanced batteries through surface modification and electron structure design. ADVS, 12(7), 2413054. (www)

  @article{ , abstract = {The design of cathode/electrolyte interfaces in high-energy density Li-ion batteries is critical to protect the surface against undesirable oxygen release from the cathodes when batteries are charged to high voltage. However, the involvement of the engineered interface in the cationic and anionic redox reactions associated with (de-)lithiation is often ignored, mostly due to the difficulty to separate these processes from chemical/catalytic reactions at the cathode/electrolyte interface. Here, a new electron energy band diagrams concept is developed that includes the examination of the electrochemical- and ionization- potentials evolution upon batteries cycling. The approach enables to forecast the intrinsic stability of the cathodes and discriminate the reaction pathways associated with interfacial electronic charge-transfer mechanisms. Specifically, light is shed on the evolution of cationic and anionic redox in high-energy density lithium-rich 0.33Li 2 MnO 3 ·0.67LiNi 0.4 Co 0.2 Mn 0.4 O 2 (HE-NCM) cathodes, particularly those that undergo surface modification through SO 2 and NH 3 double-gas treatment to suppress the structural degradation. The chemical composition and energy distribution of the occupied and unoccupied electronic states at the different charging/discharging states are quantitatively estimated by using advanced spectroscopy techniques, including operando Raman spectroscopy. The concept is successfully demonstrated in designing artificial interfaces for high-voltage olivine structure cathodes enabling stable battery operation up to 5.1 V versus Li + /Li.}, archive = {J_ADVS}, author = {Zhili Liang and Abdulaziz Baubaid and Mariusz Radtke and Maximilian Mellin and Clément Maheu and Sandipan Maiti and Hadar Sclar and Igor Píš and Silvia Nappini and Elena Magnano and Federica Bondino and Robert Winkler and René Hausbrand and Christian Hess and Lambert Alff and Boris Markovsky and Doron Aurbach and Wolfram Jaegermann and Gennady Cherkashinin}, doi = {10.1002/advs.202413054}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413054}, shortjournal = {Adv. Sci.}, title = {Novel insights into enhanced stability of li-rich layered and high-voltage olivine phosphate cathodes for advanced batteries through surface modification and electron structure design}, volume = {12}, year = {2025}, }
• (2025). Modulating acceptor phase leads to 19.59% efficiency organic solar cells. ADVS, 12(7), 2413051. (www)

  @article{ , abstract = {Nonfullerene acceptors are critical in advancing the performance of organic solar cells. However, unfavorable morphology and low photon-to-electron conversion in the acceptor range continue to limit the photocurrent generation and overall device performance. Herein, benzoic anhydride, a low-cost polar molecule with excellent synergistic properties, is introduced in combination with the traditional additive 1-chloronaphthalene to optimize the aggregation of nonfullerene acceptors. This dual additive approach precisely modulates the morphology of various acceptors, significantly enhancing device performance. Notably, the method induces the formation of fine fibers with dense polymorph structures in BTP-base derivatives, achieving an optimal balance between exciton dissociation and charge collection in the active layers. As a result, the external quantum efficiency of the optimal devices is markedly improved in the wavelength range of 700–850 nm. Ultimately, power conversion efficiencies of 18.27% and 19.59% are achieved for devices comprising PM6:Y6 and PM6:L8-BO, respectively. The results reveal a convenient and effective method to control the morphology of nonfullerene acceptors and improve the photovoltaic performance of organic solar cells, paving the way for more efficient and practical organic photovoltaic technologies.}, archive = {J_ADVS}, author = {Liang Bai and Sein Chung and Zhenmin Zhao and Jingjing Zhao and Yuqing Sun and Yuan Liu and Lixing Tan and Jiancheng Zhong and Sooji Lyu and Hojun Ji and Kilwon Cho and Zhipeng Kan}, doi = {10.1002/advs.202413051}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413051}, shortjournal = {Adv. Sci.}, title = {Modulating acceptor phase leads to 19.59% efficiency organic solar cells}, volume = {12}, year = {2025}, }
• (2025). Nanoenzymes-integrated and microenvironment self-adaptive hydrogel for the healing of burn injury and post-burn depression. ADVS, 12(7), 2413032. (www)

  @article{ , abstract = {Burn injuries often cause prolonged oxidative stress and inflammatory pain due to an initial increase in inflammatory responses, consequently exacerbating depressive disorders and severely impairing patients’ quality of life. The primary function of traditional burn dressings is to prevent infection and facilitate tissue repair. However, these dressings are not intended for the inflammatory pain and depression that often occur during recovery. This study describes a self-healing hydrogel H@EFCP, which is designed to alleviate inflammatory pain and post-burn depression in burn injuries. This hydrogel is synthesized through the cross-linking of carboxymethyl chitosan with borate ester chelates formed from epigallocatechin gallate and 4-formylphenylboronic acid. The incorporated Prussian blue nanoparticles increase the ability of H@EFCP to regulate the inflammatory process. H@EFCP is effective in the treatment of skin burns by reducing oxidative stress and improving the microenvironment of peripheral inflammation in mice. This modulation consists of a reduction of central nervous system inflammation and the risk of post-burn depression. Behavioral assays indicate that the hydrogel significantly reduces feelings of despair and anxiety after burns. Consequently, H@EFCP provides a dual-effect solution for the care and recovery of burn patients, including both burn repair and the associated psychological effects.}, archive = {J_ADVS}, author = {Weitao Zhao and Xi Chen and Ziwei Han and Zengyu Xun and Yilin Qi and Heping Wang and Chang Chen and Zhongying Gong and Xue Xue}, doi = {10.1002/advs.202413032}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2413032}, shortjournal = {Adv. Sci.}, title = {Nanoenzymes-integrated and microenvironment self-adaptive hydrogel for the healing of burn injury and post-burn depression}, volume = {12}, year = {2025}, }
• (2025). Single-cell and spatial transcriptomics delineate the microstructure and immune landscape of intrahepatic cholangiocarcinoma in the leading-edge area. ADVS, 12(7), 2412740. (www)

  @article{ , abstract = {Intrahepatic cholangiocarcinoma (ICC) tumor cells and their interactions with the immune microenvironment, particularly at the leading-edge area, have been underexplored. This study employs single-cell RNA sequencing (scRNA-seq) and spatial transcriptome (ST) analysis on samples from the tumor core, adjacent non-tumorous tissue, and the leading-edge area of nine ICC patients. These findings indicate that tumor cells at the leading-edge area demonstrate enhanced proliferation and are tightly associated with the stroma, including endothelial cells and POSTN+ FAP+ fibroblasts. Notably, CD8+ T cells in this region exhibit a naive phenotype with low cytotoxicity and signs of exhaustion, likely due to compromised antigen presentation by antigen-presenting cells (APCs). The predominant CD8+ T cell subset, mucosal-associated invariant T (MAIT) cells, recruits SPP1+ macrophages within the stroma. This interaction, along with the presence of POSTN+ cancer-associated fibroblasts (CAFs) and endothelial cells, forms a unique “triad structure” that fosters tumor growth and ICC progression. The research highlights the intricate characteristics and interactions of ICC tumor cells in the leading-edge area, offering insights into potential therapeutic targets for intervention.}, archive = {J_ADVS}, author = {Li Zuyin and Li Zhao and Cheng Qian and Zhang Changkun and Ma Delin and Hao Jialing and Chen Zhuomiaoyu and Li Yuzi and Zheng Jiaxi and Gao Jie and Zhu Jiye}, doi = {10.1002/advs.202412740}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412740}, shortjournal = {Adv. Sci.}, title = {Single-cell and spatial transcriptomics delineate the microstructure and immune landscape of intrahepatic cholangiocarcinoma in the leading-edge area}, volume = {12}, year = {2025}, }
• (2025). Real-time monitoring of volatile organic compound-mediated plant intercommunication using surface-enhanced raman scattering nanosensor. ADVS, 12(7), 2412732. (www)

  @article{ , abstract = {Plants communicate through volatile organic compounds (VOCs), but real-time monitoring of VOCs for plant intercommunication is not practically possible yet. A nanobionic VOC sensor plant is created to study VOC-mediated plant intercommunication by incorporating surface-enhanced Raman scattering (SERS) nanosensors into a living plant. This sensor allows real-time monitoring of VOC with a sensitivity down to the parts per trillion level. A quantitative VOC diffusion model in plants is proposed to describe this extreme sensitivity. The sensor plant is paired with a customized portable Raman device, demonstrating its ability to detect multiple VOCs on-field. The sensor demonstrated that plants collect VOCs emitted from neighboring plants and hazardous volatile chemicals in the air at a certain distance. As a feasibility study, this nanobionic VOC sensor plant successfully monitored the early stages of fungal infection in strawberry fruits. This result suggests that interfacing nanosensors with plants offers an innovative approach to studying interplant communication and can be used as a compelling tool for monitoring VOC occurrence.}, archive = {J_ADVS}, author = {Yun Sik Choi and Won Ki Son and Hyuna Kwak and Jiyeun Park and Sumin Choi and Daeseob Sim and Min Gyeong Kim and Hyungsuk Kimm and Hokyoung Son and Dae Hong Jeong and Seon-Yeong Kwak}, doi = {10.1002/advs.202412732}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412732}, shortjournal = {Adv. Sci.}, title = {Real-time monitoring of volatile organic compound-mediated plant intercommunication using surface-enhanced raman scattering nanosensor}, volume = {12}, year = {2025}, }
• (2025). 3D printing of porous ceramics for enhanced thermal insulation properties. ADVS, 12(7), 2412554. (www)

  @article{ , abstract = {Porous thermal insulating ceramics play a pivotal role in both industrial processes and daily life by offering effective insulation solutions that reduce energy consumption, enhance building comfort, and contribute to the sustainability of industrial production. This review offers a comprehensive examination of porous thermal insulating ceramics produced by 3D printing, providing an in-depth analysis of various 3D printing techniques and materials used to produce porous ceramics, detailing the fabrication processes, advantages, and limitations of these methods. Recent advances in 3D printed porous thermal insulating ceramics are thoroughly examined, with a particular focus on pore structure design and optimization strategies for high-performance thermal insulation. This review also addresses the challenges and barriers to widespread adoption while highlighting future research directions and emerging trends poised to drive innovation. By showcasing the transformative potential of 3D printing in revolutionizing traditional porous ceramics manufacturing methods and enhancing thermal insulation performance, this review underscores the critical role of 3D printed porous ceramics in advancing thermal insulation technology.}, archive = {J_ADVS}, author = {He Lin and Qintao Shen and Ming Ma and Renquan Ji and Huijun Guo and Huan Qi and Wang Xing and Huiping Tang}, doi = {10.1002/advs.202412554}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412554}, shortjournal = {Adv. Sci.}, title = {3D printing of porous ceramics for enhanced thermal insulation properties}, volume = {12}, year = {2025}, }
• (2025). Advanced bionic 3D interfacial solar steam generator with one-way water supply for highly efficient desalination and oil-fouling prevention. ADVS, 12(7), 2412545. (www)

  @article{ , abstract = {Interfacial solar steam generation (ISSG) employed for seawater desalination and wastewater purification shows great promise to alleviate global freshwater scarcity. However, simultaneous optimization of water transfer direction in a cost-effective and reliable ISSG to balance thermal localization, salt accumulation, and resistance to oilfouling represents a rare feat. Herein, inspired by seabird beaks for unidirectional water transfer, eco-friendly and cost-effective plant extracts, sodium alginate, and tannic acid, are selected for crafting an innovative Sodium Alginate-Tannic Acid Hemispheric Evaporator (STHE). The STHE aligned with centripetally tapered channels ensures one-directional water flow and effectively inhibits downward heat transfer, thereby boosting energy efficiency. Additionally, the integration of one-way water supply in tapered channels with interfacial evaporation of STHE, mimicking plant transpiration, collaboratively facilitates upward water transfer for a reliable solar-driven water evaporation rate of ≈2.26 kg m −2 h −1 under one sun irradiation. Even in a brine of 15.0 wt % solution, no salt crystals are observed on the surface of STHE. Hemispheric structure and superhydrophilicity are conducive to oil repellence. This work provides pivotal inspiration for constructing next-generation solar generators of high-efficiency, salt-tolerance, and anti-oil-fouling.}, archive = {J_ADVS}, author = {Yiming Bu and Xin Li and Weiwei Lei and Hongjun Yang and Weilin Xu and Qi Han and Jingliang Li}, doi = {10.1002/advs.202412545}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412545}, shortjournal = {Adv. Sci.}, title = {Advanced bionic 3D interfacial solar steam generator with one-way water supply for highly efficient desalination and oil-fouling prevention}, volume = {12}, year = {2025}, }
• (2025). Boron clusters escort doxorubicin squashing into exosomes and overcome drug resistance. ADVS, 12(7), 2412501. (www)

  @article{ , abstract = {Exosome-based drug delivery holds significant promise for cancer chemotherapy. However, current methods for loading drugs into exosomes are inefficient and cost-prohibitive for practical application. In this study, boron clusters are mixed with doxorubicin (DOX) and exosomes, enabling the efficient encapsulation of DOX into exosomes through a superchaotropic effect. Exosomes loaded with DOX and boron clusters (EDB) exhibit superior permeability and the ability to deliver higher concentrations of DOX into DOX-resistant breast cancer cells. Mechanistic analysis reveals that boron clusters form a supramolecular complex with DOX, which facilitates sustained drug release and effectively inhibits P-glycoprotein-mediated DOX efflux. As a result, EDB significantly enhance apoptosis in DOX-resistant breast cancer cells and suppress tumor growth in cases where DOX alone is ineffective, thereby extending the survival of nude mice. In summary, boron clusters effectively facilitate the incorporation of DOX into exosomes and inhibit DOX efflux, offering a novel strategy to overcome DOX resistance.}, archive = {J_ADVS}, author = {Yi-Ru Bao and Yi-Jing Chen and Xue-Fan Deng and Yi-Ke Wang and Yu-Xin Zhang and Li-Li Xu and Wei-Hua Huang and Shi-Bo Cheng and Hai-Bo Zhang and Min Xie}, doi = {10.1002/advs.202412501}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412501}, shortjournal = {Adv. Sci.}, title = {Boron clusters escort doxorubicin squashing into exosomes and overcome drug resistance}, volume = {12}, year = {2025}, }
• (2025). Spin excitations of high spin Iron(II) in Metal–Organic chains on metal and superconductor. ADVS, 12(7), 2412351. (www)

  @article{ , abstract = {Many-body interactions in metal–organic frameworks (MOFs) are fundamental for emergent quantum physics. Unlike their solution counterpart, magnetization at surfaces in low-dimensional analogues is strongly influenced by magnetic anisotropy (MA) induced by the substrate and still not well understood. Here, on-surface coordination chemistry is used to synthesize on Ag(111) and superconducting Pb(111) an iron-based spin chain by using pyrene-4,5,9,10-tetraone (PTO) precursors as ligands. Using low-temperature scanning probe microscopy, their structures and low-energy spin excitations of coordinated Fe atoms are compared with high S = 2 spin-state. Although the chain and coordination centers are identical on both substrates, the long-range spin–spin coupling due to a superexchange through the ligand on Ag is not experimentally observed on Pb(111). This reduction of spin-spin interactions on Pb in tunneling spectra is ascribed to the depletion of electronic states around the Fermi level of the Pb(111) superconductor as compared to silver.}, archive = {J_ADVS}, author = {Jung-Ching Liu and Chao Li and Outhmane Chahib and Xing Wang and Simon Rothenbühler and Robert Häner and Silvio Decurtins and Ulrich Aschauer and Shi-Xia Liu and Ernst Meyer and Rémy Pawlak}, doi = {10.1002/advs.202412351}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412351}, shortjournal = {Adv. Sci.}, title = {Spin excitations of high spin Iron(II) in Metal–Organic chains on metal and superconductor}, volume = {12}, year = {2025}, }
• (2025). Action potential firing patterns regulate dopamine release via voltage-sensitive dopamine d2 autoreceptors in mouse striatum in vivo. ADVS, 12(7), 2412229. (www)

  @article{ , abstract = {Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic and phasic action potential (AP) firing patterns in behavior mice. Besides AP numbers, whether and how different AP firing patterns per se modulate DA release remain largely unknown. Here by using in vivo and ex vivo models, it is shown that the AP frequency per se modulates DA release through the D2 receptor (D2R), which contributes up to 50% of total DA release. D2R has a voltage-sensing site at D131 and can be deactivated in a frequency-dependent manner by membrane depolarization. This voltage-dependent D2R inhibition of DA release is mediated via the facilitation of voltage-gated Ca 2+ channels (VGCCs). Collectively, this work establishes a novel mechanism that APs per se modulate DA overflow by disinhibiting the voltage-sensitive autoreceptor D2R and thus the facilitation of VGCCs, providing a pivotal pathway and insight into mammalian DA-dependent functions in vivo.}, archive = {J_ADVS}, author = {Xiaoxuan Sun and Lili Yin and Zhongjun Qiao and Muhammad Younus and Guoqing Chen and Xi Wu and Jie Li and Xinjiang Kang and Huadong Xu and Li Zhou and Yinglin Li and Min Gao and Xingyu Du and Yuqi Hang and Zhaohan Lin and Liyuan Sun and Qinglong Wang and Ruiying Jiao and Lun Wang and Meiqin Hu and Yuan Wang and Rong Huang and Yiman Li and Qihui Wu and Shujiang Shang and Shu Guo and Qian Lei and Haifeng Shu and Lianghong Zheng and Shirong Wang and Feipeng Zhu and Panli Zuo and Bing Liu and Changhe Wang and Quanfeng Zhang and Zhuan Zhou}, doi = {10.1002/advs.202412229}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412229}, shortjournal = {Adv. Sci.}, title = {Action potential firing patterns regulate dopamine release via voltage-sensitive dopamine d2 autoreceptors in mouse striatum in vivo}, volume = {12}, year = {2025}, }
• (2025). How highly heterogeneous sensors with single-molecule resolution can result in robust continuous monitoring over long time spans. ADVS, 12(7), 2412181. (www)

  @article{ , abstract = {Biomolecular sensors with single-molecule resolution are composed of multitudes of transducers that measure state changes related to single-molecular binding and unbinding events. Conventionally, signals are aggregated from many individual transducers in order to achieve sufficient statistics. However, by aggregating signals, transducer-to-transducer differences are lost and heterogeneities cannot be studied. Here, transducers with single-molecule resolution over long time spans are studied, enabling the collection of sufficient statistics from independent transducers. This allows comparisons between transducers that reveal fundamental heterogeneities in their molecular assemblies related to stochastic variations. The study is performed with biosensing by particle motion, a sensing methodology with thousands of particles that dynamically interact with a sensing surface. The signals of individual particles are studied for series of modulations of analyte concentration over 25 h. The results show large differences in individual concentration-dependent responses. Monte Carlo simulations clarify that heterogeneities can be attributed to stochastic fluctuations in the numbers of binder molecules, and that gradual changes of the response characteristics can be related to losses of molecules in the single-particle transducers. The results give insights into molecular and temporal heterogeneities of continuous transducers with single-molecule resolution and explain how sensors can be engineered to achieve robust, precise, and stable biomolecular monitoring.}, archive = {J_ADVS}, author = {Chris Vu and Junhong Yan and Arthur M. de Jong and Menno W. J. Prins}, doi = {10.1002/advs.202412181}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412181}, shortjournal = {Adv. Sci.}, title = {How highly heterogeneous sensors with single-molecule resolution can result in robust continuous monitoring over long time spans}, volume = {12}, year = {2025}, }
• (2025). A versatile drift-free super-resolution imaging method via oblique bright-field correlation. ADVS, 12(7), 2412127. (www)

  @article{ , abstract = {High-resolution optical microscopy, particularly super-resolution localization microscopy, requires precise real-time drift correction to maintain constant focus at nanoscale precision during the prolonged data acquisition. Existing methods, such as fiducial marker tracking, reflection monitoring, and bright-field image correlation, each provide certain advantages but are limited in their broad applicability. In this work, a versatile and robust drift correction technique is presented for single-molecule localization-based super-resolution microscopy. It is based on the displacement analysis of bright-field image features of the specimen with oblique illumination. By leveraging the monotonic relationship between the displacement of image features and axial positions, this method can precisely measure the drift of the imaging system in real-time with sub-nanometer precision in all three dimensions, over a broad axial range, and for various samples, including those with closely matched refractive indices. The performance of this method is validated against conventional marker-assisted techniques and demonstrates its high precision in super-resolution imaging across various biological samples. This method paves the way for fully automated drift-free super-resolution imaging systems.}, archive = {J_ADVS}, author = {Hongqiang Ma and Phuong Nguyen and Yang Liu}, doi = {10.1002/advs.202412127}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412127}, shortjournal = {Adv. Sci.}, title = {A versatile drift-free super-resolution imaging method via oblique bright-field correlation}, volume = {12}, year = {2025}, }
• (2025). A comprehensive transcriptome atlas reveals the crucial role of LncRNAs in maintaining nodulation homeostasis in soybean. ADVS, 12(7), 2412104. (www)

  @article{ , abstract = {Symbiotic nitrogen fixation (SNF) provides nitrogen for soybean. A primary challenge in enhancing yield through efficient SNF lies in striking a balance between its high energy consumption and plant growth. However, the systemic transcriptional reprogramming during nodulation remains limited. Here, this work conducts a comprehensive RNA-seq of the roots, cotyledons and leaves of inoculated-soybean. This work finds 88,814 mRNAs and 6,156 noncoding RNAs (ncRNAs) across various organs. Notably, this work identifies 6,679 nodulation-regulated mRNAs (NR-mRNAs), 1,681 long noncoding RNAs (lncRNAs) (NR-lncRNAs), and 59 miRNAs (NR-miRNAs). The majority of these NR-RNAs are associated with plant-microbial interaction and exhibit high organ specificity. Roots display the highest abundance of NR-ncRNAs and the most dynamic crosstalk between NR-lncRNAs and NR-miRNAs in a GmNARK-dependent manner. This indicates that while each tissue responds uniquely, GmNARK serves as a primary regulator of the transcriptional control of nodulated-plants. Furthermore, this work proves that lnc-NNR6788 and lnc-NNR7059 promote nodulation by regulating their target genes. This work also shows that the nodulation- and GmNARK-regulated (NNR) lnc-NNR4481 negatively regulates nodulation through miR172c within a competing endogenous RNA (ceRNA) network. The spatial organ-type transcriptomic atlas establishes a benchmark and provides a valuable resource for integrative analyses of the mechanism underlying of nodulation and plant growth balance.}, archive = {J_ADVS}, author = {Yanru Lin and Chong Chen and Weizhen Chen and Hangcheng Liu and Renhao Xiao and Hongtao Ji and Xia Li}, doi = {10.1002/advs.202412104}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412104}, shortjournal = {Adv. Sci.}, title = {A comprehensive transcriptome atlas reveals the crucial role of LncRNAs in maintaining nodulation homeostasis in soybean}, volume = {12}, year = {2025}, }
• (2025). Direct observation of hybridization between co 3d and s 2p electronic orbits: Moderating sulfur covalency to pre-activate sulfur-redox in Lithium–Sulfur batteries. ADVS, 12(7), 2412038. (www)

  @article{ , abstract = {Lithium–sulfur batteries (LSBs) offer high energy density and environmental benefits hampered by the shuttle effect related to sluggish redox reactions of long-chain lithium polysulfides (LiPSs). However, the fashion modification of the d -band center in separators is still ineffective, wherein the mechanism understanding always relies on theoretical calculations. This study visibly probed the evolution of the Co 3 d -band center during charge and discharge using advanced inverse photoemission spectroscopy/ultraviolet photoemission spectroscopy (IPES/UPS), which offers reliable evidence and are consistent well with theoretical calculations. This, coupled with in situ Raman and X-ray diffraction (XRD) and electrochemical data, co-evidences a novel pre-activating S redox mechanism in LSBs: LiPSs desert/insert in C-N matrixes within a series of Co@NCNT-based separators. The insight of the S redox pre-activation is discovered that the Co 3 d -band center downshifts to hybridized with S 2 p orbitals in LiPSs, giving rise to a more pronounced S covalency and thus accelerating the conversion of LiPSs to S₈. Benefiting from these advantages, the optimized LSB possesses a minimal decay rate of 0.0058% after 200 cycles at a high discharge rate of 10 C. This study provides new insights into LSB mechanisms and supports conventional theoretical models of the d -band center's impact on LSB performance.}, archive = {J_ADVS}, author = {Di Wang and Yaozu Jia and Qi Jin and Fengying Tian and Qiong Gao and Xu Xu and Huiqing Lu and Lili Wu and Xinzhi Ma and Xitian Zhang}, doi = {10.1002/advs.202412038}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412038}, shortjournal = {Adv. Sci.}, title = {Direct observation of hybridization between co 3d and s 2p electronic orbits: Moderating sulfur covalency to pre-activate sulfur-redox in Lithium–Sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). Microphysiological system-generated physiological shear forces reduce TNF-α-mediated cartilage damage in a 3D model of arthritis. ADVS, 12(7), 2412010. (www)

  @article{ , abstract = {Osteoarthritis (OA) is a leading cause of disability, often resulting from overuse or injury, but inactivity can also contribute to cartilage degeneration. Conventional in vivo models struggle to isolate and study the specific effects of mechanical stress on cartilage health. To address this limitation, a microphysiological system (MPS) is established to examine how varying levels of shear stress impact cartilage homeostasis. The system allows for the cultivation of 3D chondrogenic microconstructs (CMCs) derived from human mesenchymal stromal cells, simulating both physiological and pathophysiological shear stress. Inflammation is induced via TNF-α or activated peripheral blood mononuclear cells to model cartilage damage, enabling the evaluation of therapeutic interventions. The study demonstrates the development of an arthritis-like phenotype and successful restoration of cartilage conditions through a JAK inhibitor under physiological shear stress. Physiological shear stress is identified as a critical factor in maintaining cartilage integrity. This MPS offers a standardized method to study shear stress, replicate cytokine-induced cartilage damage, and simulate key features of arthritis, providing a valuable alternative to animal models.}, archive = {J_ADVS}, author = {Alexandra Damerau and Duc Ha Do Nguyen and Christina Lubahn and Kasper Renggli and Moritz Pfeiffenberger and Gerhard Krönke and Matthias Herrmann and Thomas Leeuw and Frank Buttgereit and Timo Gaber}, doi = {10.1002/advs.202412010}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412010}, shortjournal = {Adv. Sci.}, title = {Microphysiological system-generated physiological shear forces reduce TNF-α-mediated cartilage damage in a 3D model of arthritis}, volume = {12}, year = {2025}, }
• (2025). A novel nuclear protein complex controlling the expression of developmentally regulated genes in toxoplasma gondii. ADVS, 12(7), 2412000. (www)

  @article{ , abstract = {Toxoplasma gondii is a ubiquitous protozoan parasite with a complex life cycle containing multiple developmental stages. The parasites have distinct gene expression patterns at different stages to enable stage specific life activities, but the underlying regulatory mechanisms are largely unknown. In this study, a nuclear complex is identified that controls the expression of developmentally regulated genes. This complex consists of the AP2 family transcription factor AP2XII-5, the epigenetic factors MORC and HDAC3, as well as a novel AP2XII-5 interacting protein 1 (AIP1) that stabilizes this complex. At the tachyzoite stage when the parasites proliferate rapidly by asexual endodyogeny, AP2XII-5 binds to the promoter regions of developmentally activated genes and recruits MORC and HDAC3 to suppress their expression. When sexual commitment and merozoite development are triggered, the abundance of AP2XII-5 decreases and its suppression on target genes is relieved. In contrast to MORC and HDAC3, which regulate Toxoplasma development but are also essential for tachyzoite growth, AP2XII-5 and AIP1 are dispensable for tachyzoite proliferation in vitro. These data suggest that while MORC and HDAC3 have broad regulatory activities, forming a complex with AP2XII-5 and AIP1 enables them to specifically regulate gene expression during development.}, archive = {J_ADVS}, author = {Lilan Xue and Jingwen Zhang and Lihong Zhang and Fuqiang Fan and Xiaoyan Yin and Hengrui Tian and Bang Shen}, doi = {10.1002/advs.202412000}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2412000}, shortjournal = {Adv. Sci.}, title = {A novel nuclear protein complex controlling the expression of developmentally regulated genes in toxoplasma gondii}, volume = {12}, year = {2025}, }
• (2025). Recent advances and perspectives on coupled water electrolysis for energy-saving hydrogen production. ADVS, 12(7), 2411964. (www)

  @article{ , abstract = {Overall water splitting (OWS) to produce hydrogen has attracted large attention in recent years due to its ecological-friendliness and sustainability. However, the efficiency of OWS has been forced by the sluggish kinetics of the four-electron oxygen evolution reaction (OER). The replacement of OER by alternative electrooxidation of small molecules with more thermodynamically favorable potentials may fundamentally break the limitation and achieve hydrogen production with low energy consumption, which may also be accompanied by the production of more value-added chemicals than oxygen or by electrochemical degradation of pollutants. This review critically assesses the latest discoveries in the coupled electrooxidation of various small molecules with OWS, including alcohols, aldehydes, amides, urea, hydrazine, etc. Emphasis is placed on the corresponding electrocatalyst design and related reaction mechanisms (e.g., dual hydrogenation and N–N bond breaking of hydrazine and C═N bond regulation in urea splitting to inhibit hazardous NCO − and NO − productions, etc.), along with emerging alternative electrooxidation reactions (electrooxidation of tetrazoles, furazans, iodide, quinolines, ascorbic acid, sterol, trimethylamine, etc.). Some new decoupled electrolysis and self-powered systems are also discussed in detail. Finally, the potential challenges and prospects of coupled water electrolysis systems are highlighted to aid future research directions.}, archive = {J_ADVS}, author = {Jiachen Li and Yuqiang Ma and Xiaogang Mu and Xuanjun Wang and Yang Li and Haixia Ma and Zhengxiao Guo}, doi = {10.1002/advs.202411964}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411964}, shortjournal = {Adv. Sci.}, title = {Recent advances and perspectives on coupled water electrolysis for energy-saving hydrogen production}, volume = {12}, year = {2025}, }
• (2025). N-glycosylation modification of CTSD affects liver metastases in colorectal cancer. ADVS, 12(7), 2411740. (www)

  @article{ , abstract = {Liver metastasis is the primary factor contributing to unfavorable prognosis in colorectal cancer (CRC). Although N -glycosylation is implicated in metastasis, there is a notable paucity of comprehensive studies addressing the N -glycosylation proteomics associated with liver metastasis in CRC. In this study, N- glycosylated proteins and N- glycosylation sites of differential expression between primary lesions and paired liver metastatic lesions are identified. Cathepsin D (CTSD) is further screened as a potentially pivotal N- glycosylated protein in CRC liver metastasis. Glycosyltransferases complex DDOST and STT3B can regulate N- glycosylation modification at residue 263 of CTSD (a protease), thereby affecting CTSD protease to lyse ACADM. ACADM can regulate ferroptosis-related proteins (ACSL4, SLC7A11, and GPX4) to further influence the invasion and metastasis of CRC cells. This newly discovered mechanism provides potential therapeutic targets for CRC treatment and insights for controlling CRC progression and metastasis.}, archive = {J_ADVS}, author = {Nan Xiong and Yan Du and Chuncui Huang and Quanyi Yan and Long Zhao and Changjiang Yang and Qing Sun and Zhidong Gao and Caihong Wang and Jun Zhan and Hongquan Zhang and Shan Wang and Yingjiang Ye and Yan Li and Zhanlong Shen}, doi = {10.1002/advs.202411740}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411740}, shortjournal = {Adv. Sci.}, title = {N-glycosylation modification of CTSD affects liver metastases in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Organelle-targeting nanoparticles. ADVS, 12(7), 2411720. (www)

  @article{ , abstract = {Organelles are specialized subunits within cells which carry out vital functions crucial to cellular survival and form a tightly regulated network. Dysfunctions in any of these organelles are linked to numerous diseases impacting virtually every organ system in the human body. Targeted delivery of therapeutics to specific organelles within the cell holds great promise for overcoming challenging diseases and improving treatment outcomes through the minimization of therapeutic dosage and off-target effects. Nanoparticles are versatile and effective tools for therapeutic delivery to specific organelles. Nanoparticles offer several advantageous characteristics, including a high surface area-to-volume ratio for efficient therapeutic loading and the ability to attach targeting moieties (tethers) that enhance delivery. The choice of nanoparticle shape, size, composition, surface properties, and targeting ligands depends on the desired target organelle and therapeutic effect. Various nanoparticle platforms have been explored for organelle targeting, such as liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles. In this review, current and emerging approaches to nanoparticle design are examined in the context of various diseases linked to organelle dysfunction. Specifically, advances in nanoparticle therapies targeting organelles such as the nucleus, mitochondria, lysosomes/endosomes, Golgi apparatus, and endoplasmic reticulum are comprehensively and critically discussed.}, archive = {J_ADVS}, author = {John Soukar and Nicholas A. Peppas and Akhilesh K. Gaharwar}, doi = {10.1002/advs.202411720}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411720}, shortjournal = {Adv. Sci.}, title = {Organelle-targeting nanoparticles}, volume = {12}, year = {2025}, }
• (2025). Optimization of thermoelectric performance in p-type SnSe crystals through localized lattice distortions and band convergence. ADVS, 12(7), 2411594. (www)

  @article{ , abstract = {Crystalline thermoelectric materials, especially SnSe crystals, have emerged as promising candidates for power generation and electronic cooling. In this study, significant enhancement in ZT is achieved through the combined effects of lattice distortions and band convergence in multiple electronic valence bands. Density functional theory (DFT) calculations demonstrate that cation vacancies together with Pb substitutional doping promote the band convergence and increase the density of states (DOS) near the Fermi surface of SnSe, leading to a notable increase in the Seebeck coefficient ( S ). The complex defects formed by Sn vacancies and Pb doping not only boost the Seebeck coefficient but also optimize carrier concentration ( n H ) and enhance electrical conductivity ( σ ), resulting in a higher power factor ( PF ). Furthermore, the localized lattice distortions induced by these defects increase phonon scattering, significantly reducing lattice thermal conductivity ( κ lat ) to as low as 0.29 W m −1 K −1 at 773 K in Sn 0.92 Pb 0.03 Se. Consequently, these synergistic effects on phonon and electron transport contribute to a high ZT of 1.8. This study provides a framework for rational design of high-performance thermoelectric materials based on first-principles insights and experimental validation.}, archive = {J_ADVS}, author = {Suniya Siddique and Ghulam Abbas and Manzar Mushaf Yaqoob and Jian Zhao and RuiHua Chen and J. Andreas Larsson and Yuede Cao and Yuexing Chen and Zhuanghao Zheng and Dongping Zhang and Fu Li}, doi = {10.1002/advs.202411594}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411594}, shortjournal = {Adv. Sci.}, title = {Optimization of thermoelectric performance in p-type SnSe crystals through localized lattice distortions and band convergence}, volume = {12}, year = {2025}, }
• (2025). Ultraflexible sensor development via 4D printing: Enhanced sensitivity to strain, temperature, and magnetic fields. ADVS, 12(7), 2411584. (www)

  @article{ , abstract = {This paper addresses the trade-off between sensitivity and sensing range in strain sensors, while introducing additional functionalities through an innovative 4D printing approach. The resulting ultraflexible sensor integrates carbon nanotubes/liquid metal hybrids and iron powders within an Ecoflex matrix. The optimization of this composition enables the creation of an uncured resin ideal for Direct Ink Writing (DIW) and a cured sensor with exceptional electromechanical, thermal, and magnetic performance. Notably, the sensor achieves a wide linear strain range of 350% and maintains a stable Gauge Factor of 19.8, offering an ultralow detection limit of 0.1% strain and a rapid 83-ms response time. Beyond superior strain sensing capabilities, the sensor exhibits outstanding thermal endurance for temperatures exceeding 300 °C, enhanced thermal conductivity, and a consistent resistance-temperature relationship, making it well-suited for high-temperature applications. Moreover, the inclusion of iron particles provides magnetic responsiveness, enabling synergistic applications in location and speed detection, particularly in home care. Leveraging DIW facilitates the creation of complex-shaped sensors with multiple functional materials, significantly broadening the sensor's capabilities. This convergence of additive manufacturing and multifunctional materials marks a transformative step in advancing the performance of next-generation sensors across diverse domains.}, archive = {J_ADVS}, author = {Yanbei Hou and Hancen Zhang and Kun Zhou}, doi = {10.1002/advs.202411584}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411584}, shortjournal = {Adv. Sci.}, title = {Ultraflexible sensor development via 4D printing: Enhanced sensitivity to strain, temperature, and magnetic fields}, volume = {12}, year = {2025}, }
• (2025). Novel naphthyridones targeting pannexin 1 for colitis management. ADVS, 12(7), 2411538. (www)

  @article{ , abstract = {Pannexin 1 (PANX1) forms cell-surface channels capable of releasing signaling metabolites for diverse patho-physiological processes. While inhibiting dysregulated PANX1 has been proposed as a therapeutic strategy for many pathological conditions, including inflammatory bowel disease (IBD), low efficacy, or poor specificity of classical PANX1 inhibitors introduces uncertainty for their applications in basic and translational research. Here, hit-to-lead optimization is performed and a naphthyridone, compound 12 , is identified as a new PANX1 inhibitor with an IC 50 of 0.73 µ m that does not affect pannexin-homologous LRRC8/SWELL1 channels. Using structure–activity relationship analysis, mutagenesis, cell thermal shift assays, and molecular docking, it is revealed that compound 12 directly engages PANX1 Trp74 residue. Using a dextran sodium sulfate mouse model of IBD, it is found that compound 12 markedly reduced colitis severity, highlighting new PANX1 inhibitors as a proof-of-concept treatment for IBD. These data describe the mechanism of action for a new PANX1 inhibitor, uncover the binding site for future drug design, and present a targeted strategy for treating IBD.}, archive = {J_ADVS}, author = {Wen-Yun Hsueh and Yi-Ling Wu and Meng-Tzu Weng and Shin-Yun Liu and Jascinta P Santavanond and Yi-Chung Liu and Ching-I Lin and Cheng-Nong Lai and Yi-Ru Lu and Jing Yin Hsu and Hong-Yu Gao and Jinq-Chyi Lee and Shu-Chen Wei and Ping-Chiang Lyu and Ivan K H Poon and Hsing-Pang Hsieh and Yu-Hsin Chiu}, doi = {10.1002/advs.202411538}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411538}, shortjournal = {Adv. Sci.}, title = {Novel naphthyridones targeting pannexin 1 for colitis management}, volume = {12}, year = {2025}, }
• (2025). Spatially selective imaging in color: What you see is what you want. ADVS, 12(7), 2411537. (www)

  @article{ , abstract = {Spatially selective imaging (SSI) involves sampling a group of pixels from different positions on an encoded object to display a decoded image. Here, SSI is achieved by using off-axis cylindrical Fresnel lens arrays to decode multiple images from an encoded print of structural color pixels. Each image is optically retrieved by separately placing different “keys” (arrays of lenses in different pseudorandom configurations) over the same encoded print, and then each image is digitally reconstructed for visualization. In addition, a detailed analysis is presented on the designed lenses and pixels, which are all fabricated by two-photon polymerization lithography. Though Fresnel lenses are susceptible to chromatic aberrations, the results show that they can be used for imaging pixels that produce a wide range of colors at low numerical aperture ( NA ≈0.2). The images have acceptable color contrast, corresponding to a simulated normalized modulation transfer function ( MTF ) of ≈0.6 averaged across wavelengths in the visible spectrum. This work can find applications in optical information security devices.}, archive = {J_ADVS}, author = {John You En Chan and Akshaya Rajesh and Xiaoyu Lin and Hao Wang and Hongtao Wang and Xiaoyan Zhou and Cheng-Wei Qiu and Joel K.W. Yang}, doi = {10.1002/advs.202411537}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411537}, shortjournal = {Adv. Sci.}, title = {Spatially selective imaging in color: What you see is what you want}, volume = {12}, year = {2025}, }
• (2025). Expanding cas12a activity control with an RNA G-quadruplex at the 5′ end of CRISPR RNA. ADVS, 12(7), 2411305. (www)

  @article{ , abstract = {Precise control of Cas12a activity is essential for the improvement of the detection limit of clinical diagnostics and the minimization of errors. This study addresses the challenge of controlling Cas12a activity, especially in the context of nucleic acid detection where the inherent incompatibility between isothermal amplification and CRISPR reactions complicates accurate diagnostics. An RNA G-quadruplex (RG4) structure at the 5′ end of crRNA is introduced to modulate Cas12a activity accurately without the need for chemical modifications. The results indicate that the presence of RG4 does not significantly impact Cas12a's cleavage activity but can be controlled by RG4 stabilizers, enabling the suppression and subsequent restoration of Cas12a activity with potential for precise activity control. Moreover, the use of RG4 is expanded by incorporating it into split crRNA, introducing RG4 directly at the 5′ end of the direct repeat (DR) region, enabling tailored activity regulation for different targets by matching with various Spacer regions. Additionally, a light-controlled one-pot method for activating Cas12a is developed, thereby enhancing the accuracy and sensitivity of clinical samples. This study showcases the pioneering use of RG4 in manipulating Cas12a activity, streamlining diagnostics, and paving the way for advances in clinical nucleic acid testing.}, archive = {J_ADVS}, author = {Wenjuan Huang and Jiaqi Wang and Cheng Wang and Yuanfang Liu and Wentao Li and Qiaozhen Chen and Junqiu Zhai and Zhenyang Xiang and Chaoxing Liu}, doi = {10.1002/advs.202411305}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411305}, shortjournal = {Adv. Sci.}, title = {Expanding cas12a activity control with an RNA G-quadruplex at the 5′ end of CRISPR RNA}, volume = {12}, year = {2025}, }
• (2025). SPP1-ITGα5/β1 accelerates calcification of nucleus pulposus cells by inhibiting mitophagy via ubiquitin-dependent PINK1/PARKIN pathway blockade. ADVS, 12(7), 2411162. (www)

  @article{ , abstract = {Low back pain (LBP) caused by nucleus pulposus degeneration and calcification leads to great economic and social burden worldwide. Unexpectedly, no previous studies have demonstrated the association and the underlying mechanism between nucleus pulposus tissue degeneration and calcification formation. Secreted Phosphoprotein 1 (SPP1) exerts crucial functions in bone matrix mineralization and calcium deposition. Here, a novel function of SPP1 is reported, namely that it can aggravate nucleus pulposus cells (NPs) degeneration by negatively regulating extracellular matrix homeostasis. The degenerated NPs have a higher mineralization potential, which is achieved by SPP1. Mechanistically, SPP1 can accelerate the degeneration of nucleus pulposus cells by activating integrin α5β1 (ITGα5/β1), aggravating mitochondrial damage and inhibiting mitophagy. SPP1-ITGα5/β1 axis inhibits mitophagy by PINK1/PARKIN pathway blockade. In conclusion, SPP1 activates ITGα5/β1 to inhibit mitophagy, accelerates NPs degeneration, and induces calcification, thereby leading to intervertebral disc degeneration (IVDD) and calcification, identifying the potentially unknown mechanism and relationship between IVDD and calcification. Important insights are provided into the role of SPP1 in nucleus pulposus calcification in IVDD by inducing nucleus pulposus cell senescence through inhibition of mitophagy and may help develop potential new strategies for IVDD treatment.}, archive = {J_ADVS}, author = {Hanwen Gu and Qi Li and Zhenchuan Liu and Yanlin Li and Kaiwen Liu and Xiangzhen Kong and Yuanqiang Zhang and Qunbo Meng and Kangle Song and Qing Xie and Yuan Gao and Lei Cheng}, doi = {10.1002/advs.202411162}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411162}, shortjournal = {Adv. Sci.}, title = {SPP1-ITGα5/β1 accelerates calcification of nucleus pulposus cells by inhibiting mitophagy via ubiquitin-dependent PINK1/PARKIN pathway blockade}, volume = {12}, year = {2025}, }
• (2025). Convergent patterns of karyotype evolution underlying karyotype uniformity in conifers. ADVS, 12(7), 2411098. (www)

  @article{ , abstract = {Karyotype diversity plays an important role in speciation and diversification. However, gymnosperms, particularly conifers, exhibit remarkable karyotype uniformity. To explore the evolutionary processes shaping karyotypes in gymnosperms, the karyotype evolutionary history is reconstructed through comparative genomic analyses. Synteny analysis confirms the absence of ancient polyploidy in conifers and its rarity across the gymnosperms as a whole. Further analysis reveals convergent patterns of reciprocal translocations between nonhomologous chromosomes in conifer genomes. Centromeric-centromeric reciprocal translocations (CRTs) have been identified as the primary mechanism of karyotype evolution in conifers, while telomeric-centromeric reciprocal translocations (TRTs) significantly contributed to descending dysploidy within Cupressales. A graph-based method is utilized to infer the detailed evolutionary pathways from the proto-gymnosperm karyotype ( n = 12) to modern conifer karyotypes ( n = 11–12). In conclusion, the scarcity of both polyploidy and dysploidy contributes to the karyotype uniformity of gymnosperms and potentially also to their lower species richness compared to angiosperms. However, the pervasive CRTs and occasional TRTs underlie this “apparent uniformity”, supporting the “karyotype orthoselection” hypothesis. This study provides new insights into the mechanisms maintaining karyotype uniformity in conifers and the role of karyotype evolution in their diversification.}, archive = {J_ADVS}, author = {Ren-Gang Zhang and Hui Liu and Hong-Yun Shang and Heng Shu and De-Tuan Liu and Hao Yang and Kai-Hua Jia and Xiao-Quan Wang and Wei-Bang Sun and Wei Zhao and Yongpeng Ma}, doi = {10.1002/advs.202411098}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411098}, shortjournal = {Adv. Sci.}, title = {Convergent patterns of karyotype evolution underlying karyotype uniformity in conifers}, volume = {12}, year = {2025}, }
• (2025). Targeted CRISPR/Cas9 lipid nanoparticles elicits therapeutic genome editing in head and neck cancer. ADVS, 12(7), 2411032. (www)

  @article{ , abstract = {Squamous cell carcinomas of the head and neck (HNSCC) originate in the upper aerodigestive tract, including the oral cavity, pharynx, and larynx. Current treatments of locally advanced HNSCC often lead to high treatment failure, and disease recurrence, resulting in poor survival rates. Advances in mRNA technologies and lipid nanoparticle (LNP) delivery systems led to several clinical trials involving LNP-CRISPR-Cas9 mRNA-based therapeutics. Despite these advances, achieving cell-type-specific extrahepatic mRNA delivery is still challenging. This study introduces a safe and effective intratumoral EGFR-targeted CRISPR-LNP delivery strategy for knocking out SOX2, which is a cancer-specific gene. To assess their therapeutic potential, it is shown that LNPs made from ionizable lipids with helper lipids co-encapsulating Cas9 mRNA and sgRNA targeting SOX2 (sgSOX2), lead to a ≈60% reduction in HNSCC cell viability in vitro. Next, using a xenograft HNSCC mouse model, targeted delivery of 𝜶EGFR- CRISPR-sgSOX2-LNPs to HNSCC cells resulted in a 90% inhibition of tumor growth and a 90% increase in survival for > 84 days, with tumor disappearance observed in 50% of the mice. These findings emphasize the potential of targeted mRNA-Cas9-LNPs in clinically accessible solid tumors, specifically in reaching tumor cells and inducing persistent therapeutic responses in tumors with high-recurrence rates like HNSCC.}, archive = {J_ADVS}, author = {Razan Masarwy and Dor Breier and Lior Stotsky-Oterin and Nitay Ad-El and Shahd Qassem and Gonna Somu Naidu and Anjaiah Aitha and Assaf Ezra and Meir Goldsmith and Inbal Hazan-Halevy and Dan Peer}, doi = {10.1002/advs.202411032}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2411032}, shortjournal = {Adv. Sci.}, title = {Targeted CRISPR/Cas9 lipid nanoparticles elicits therapeutic genome editing in head and neck cancer}, volume = {12}, year = {2025}, }
• (2025). Tertiary lymphoid structures are linked to enhanced antitumor immunity and better prognosis in muscle-invasive bladder cancer. ADVS, 12(7), 2410998. (www)

  @article{ , abstract = {The prognosis for muscle-invasive bladder cancer (MIBC) remains poor, and reliable prognostic markers have yet to be identified. Tertiary lymphoid structures (TLS) have been associated with favorable outcomes in certain cancers. However, the relationship between TLS and MIBC remains unclear. A multi-omics approach is utilized, leveraging single-cell RNA sequencing, spatial transcriptomics, bulk RNA sequencing, and immunohistochemistry, to investigate the roles of B cells and TLS in MIBC. These findings indicate that elevated levels of B cells and TLS correlate with improved prognoses in patients with MIBC, aligning with the robust antitumor immune responses observed in the TLS region. From a mechanistic perspective, CXCL13 serves as a critical cytokine for TLS formation in MIBC, primarily secreted by clonally expanded CXCL13+ T cells. This cytokine interacts with the CXCR5 receptor on NR4A2+ B cells, promoting TLS development. Plasma cells arising within the TLS microenvironment predominantly produce the IGHG antibody, potentially enhancing the phagocytic capabilities of C1QC+ macrophages. From an application standpoint, a TLS-specific gene signature is developed that effectively predicts outcomes in MIBC and other cancers. This study highlights the prognostic potential of TLS in MIBC and reveals immune mechanisms, offering insights for personalized treatment strategies.}, archive = {J_ADVS}, author = {Jiaxing Lin and Shan Jiang and Baoqiang Chen and Yiqing Du and Caipeng Qin and Yuxuan Song and Yun Peng and Mengting Ding and Jilin Wu and Yihan Lin and Tao Xu}, doi = {10.1002/advs.202410998}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410998}, shortjournal = {Adv. Sci.}, title = {Tertiary lymphoid structures are linked to enhanced antitumor immunity and better prognosis in muscle-invasive bladder cancer}, volume = {12}, year = {2025}, }
• (2025). Propagation of orientation across lengthscales in sheared self-assembling hierarchical suspensions via rheo-PLI-SAXS. ADVS, 12(7), 2410920. (www)

  @article{ , abstract = {Simultaneous rheological, polarized light imaging, and small-angle X-ray scattering experiments (Rheo-PLI-SAXS) are developed, thereby providing unprecedented level of insight into the multiscale orientation of hierarchical systems in simple shear. Notably, it is observed that mesoscale alignment in the flow direction does not develop simultaneously across nano-micro lengthscales in sheared suspensions of rod-like chiral-nematic (meso) phase forming cellulose nanocrystals. Rather, with increasing shear rate, orientation is observed first at mesoscale and then extends to the nanoscale, with influencing factors being the aggregation state of the hierarchy and concentration. In biphasic systems, where an isotropic phase co-exists with self-assembled liquid crystalline mesophase domains, the onset of mesodomain alignment towards the flow direction can occur at shear rates nearing one decade before a progressive increase in preferential orientation at nanoscale is detected. If physical confinement prevents the full formation of a cholesteric phase, mesoscale orientation occurs in shear rate ranges that correspond to de-structuring at nanoscale. Interestingly, nano- and mesoscale orientations appear to converge only for biphasic suspensions with primary nanoparticles predominantly made up of individual crystallites and in a high-aspect ratio nematic-forming thin-wall nanotube system. The nano-micro orientation propagation is attributed to differences in the elongation and breakage of mesophase domains.}, archive = {J_ADVS}, author = {Reza Ghanbari and Ann Terry and Sylwia Wojno and Marko Bek and Kesavan Sekar and Amit Kumar Sonker and Kim Nygård and Viney Ghai and Simona Bianco and Marianne Liebi and Aleksandar Matic and Gunnar Westman and Tiina Nypelö and Roland Kádár}, doi = {10.1002/advs.202410920}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410920}, shortjournal = {Adv. Sci.}, title = {Propagation of orientation across lengthscales in sheared self-assembling hierarchical suspensions via rheo-PLI-SAXS}, volume = {12}, year = {2025}, }
• (2025). Interfacial engineering to fabricate nanoporous FeMo bimetallic nitride for enhanced electrochemical ammonia synthesis. ADVS, 12(7), 2410805. (www)

  @article{ , abstract = {The electrochemical N 2 reduction reaction (NRR) currently represents a green and sustainable approach to ammonia production. However, the further progress of NRR is significantly hampered by poor catalytic activity and selectivity, necessitating the development of efficient and stable electrocatalysts. Herein, a nanoporous Fe–Mo bimetallic nitride (Fe 3 N-MoN) is synthesized using a molten-salt preparation method. This catalyst demonstrates notable NRR performance, achieving a high NH 3 yield rate of 45.1 µg h −1 mg −1 and a Faradaic efficiency (FE) of 26.5% at −0.2 V (vs RHE) under ambient conditions. Detailed experimental studies and density functional theory (DFT) calculations reveal that the fabricated interface between Fe 3 N and MoN effectively modulates the surface electronic structure of the catalyst. The interface induces an increase in the degree of electron deficiency at the nitrogen-vacancy sites on the catalyst surface, allowing N 2 molecules to occupy the nitrogen vacancies more easily, thereby promoting N 2 adsorption/activation during the NRR process. Consequently, the Fe 3 N-MoN catalyst exhibits outstanding NRR activity. The insights gained from fabricating the Fe 3 N-MoN interface in this work pave the way for further development of interfacial engineering to prepare high-efficient electrocatalyst.}, archive = {J_ADVS}, author = {Bin Fang and Liyuan Zhao and Yanqin Li and Nianliang Yin and Xin Wang and Jutao Jin and Wenlong Wang}, doi = {10.1002/advs.202410805}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410805}, shortjournal = {Adv. Sci.}, title = {Interfacial engineering to fabricate nanoporous FeMo bimetallic nitride for enhanced electrochemical ammonia synthesis}, volume = {12}, year = {2025}, }
• (2025). Circular-gate nanoscale air channel transistors: Achieving ultralow subthreshold swing and working voltage. ADVS, 12(7), 2410734. (www)

  @article{ , abstract = {As electronics advance toward higher performance and adaptability in extreme environments, traditional metal-oxide-semiconductor field-effect transistors (MOSFETs) face challenges due to physical constraints such as Boltzmann's law and short-channel effects. Nanoscale air channel transistors (NACTs) present a promising alternative, leveraging their vacuum-like channel and Fowler–Nordheim tunneling characteristics. In this study, a novel circular gate NACT (CG-NACT) is purposed, fabricated on a 4-inch silicon-based wafer using a CMOS-compatible process. By employing an innovative gate control mechanism, the transistors achieve an ultralow SS of only 0.15 mV dec −1 and maintain the average SS remained at 1.5 mV dec −1 over three decades of drain current. Additionally, our CG-NACTs deliver milliamper-level drain current at a low drain voltage of 0.7 V, with a maximum on/off ratio of 7.82×10 6 . Notably, CG-NACTs remain highly stable even at high temperatures of up to 150 °C and under irradiation. Furthermore, the practical application of CG-NACTs is successfully implemented by designing an inverter circuit for the first time.}, archive = {J_ADVS}, author = {Haiquan Zhao and Feiliang Chen and Yazhou Wei and Lixin Sun and Ruihan Huang and Xiangdong Wang and Fan Yang and Hao Jiang and Yang Liu and Mo Li and Jian Zhang}, doi = {10.1002/advs.202410734}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410734}, shortjournal = {Adv. Sci.}, title = {Circular-gate nanoscale air channel transistors: Achieving ultralow subthreshold swing and working voltage}, volume = {12}, year = {2025}, }
• (2025). An artificial neural network for image classification inspired by the aversive olfactory learning neural circuit in caenorhabditis elegans. ADVS, 12(7), 2410637. (www)

  @article{ , abstract = {This study introduces an artificial neural network (ANN) for image classification task, inspired by the aversive olfactory learning neural circuit in Caenorhabditis elegans ( C. elegans ). Although artificial neural networks (ANNs) have demonstrated remarkable performance in various tasks, they still encounter challenges including excessive parameterization, high training costs and limited generalization capabilities, etc. C. elegans , boasting a simple nervous system consisting of merely 302 neurons, is capable of exhibiting complex behaviors such as aversive olfactory learning. This research pinpoints key neural circuit related to aversive olfactory learning in C. elegans by means of behavioral experiment and high-throughput RNA sequencing, and then translates it into an architecture of ANN for image classification. Furthermore, other ANNs for image classification with different architectures are constructed for comparative performance analysis to underscore the advantages of the bio-inspired designed architecture. The results show that the ANN inspired by the aversive olfactory learning neural circuit in C. elegans attains higher accuracy, greater consistency and faster convergence rate in the image classification task, particularly when dealing with more complex classification challenges. This study not only demonstrates the potential of bio-inspired design in improving the capabilities of ANNs but also offers a novel perspective and methodology for future ANNs design.}, archive = {J_ADVS}, author = {Xuebin Wang and Chunxiuzi Liu and Meng Zhao and Ke Zhang and Zengru Di and He Liu}, doi = {10.1002/advs.202410637}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410637}, shortjournal = {Adv. Sci.}, title = {An artificial neural network for image classification inspired by the aversive olfactory learning neural circuit in caenorhabditis elegans}, volume = {12}, year = {2025}, }
• (2025). Graphene quantum dot sensitized heterojunctions induce tumor-specific cuproptosis to boost sonodynamic and chemodynamic enhanced cancer immunotherapy. ADVS, 12(7), 2410606. (www)

  @article{ , abstract = {Cuproptosis that utilizes copper ionophore to induce programmed cell death holds promise for enhancing the effectiveness of conventional anticancer therapies and triggering efficient adaptive immune responses. However, the non-tumor-specific release of Cu ions can induce cuproptosis and cause irreversible damage to normal tissues. To maximize the therapeutic effects of tumor-specific cuproptosis, this work reports for the first time the regulation of degradation behaviors of Cu-based nanomaterials using graphene quantum dots (GQDs) as a protection layer. The deposition of GQDs not only avoids the degradation of Cu 2 O nanocubes under normal physiological conditions, but also sensitizes their sonodynamic activity due to the formation of Z-scheme heterojunctions. The tumor-specific released Cu ions achieve the cascade amplification of reactive oxygen species (ROS) generation through Cu + -mediated Fenton-like reaction and Cu 2+ -facilitated GSH depletion. More importantly, the immunosuppressive tumor microenvironment (TME) can be reversed by the greatly enhanced ROS levels and high-efficiency cuproptosis, ultimately inducing immunogenic cell death that promotes robust systemic immune responses for the eradication of primary tumors and suppression of distant tumors. This work provides a novel paradigm for the integration of SDT, CDT, cuproptosis, and immunotherapy in a controlled manner to achieve tumor-specific antitumor therapy by controlling the degradation behaviors of Cu-based nanomaterials.}, archive = {J_ADVS}, author = {Lang Yan and Liang Chang and Yijun Tian and Jinyan Hu and Zhi Cao and Xiang Guo and Bijiang Geng}, doi = {10.1002/advs.202410606}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410606}, shortjournal = {Adv. Sci.}, title = {Graphene quantum dot sensitized heterojunctions induce tumor-specific cuproptosis to boost sonodynamic and chemodynamic enhanced cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). In vivo neurodynamics mapping via high-speed two-photon fluorescence lifetime volumetric projection microscopy. ADVS, 12(7), 2410605. (www)

  @article{ , abstract = {Monitoring the morphological and biochemical information of neurons and glial cells at high temporal resolution in three-dimensional (3D) volumes of in vivo is pivotal for understanding their structure and function, and quantifying the brain microenvironment. Conventional two-photon fluorescence lifetime volumetric imaging speed faces the acquisition speed challenges of slow serial focal tomographic scanning, complex post-processing procedures for lifetime images, and inherent trade-offs among contrast, signal-to-noise ratio, and speed. This study presents a two-photon fluorescence lifetime volumetric projection microscopy using an axially elongated Bessel focus and instant frequency-domain fluorescence lifetime technique, and integrating with a convolutional network to enhance the imaging speed for in vivo neurodynamics mapping. The proposed method is validated by monitoring intracellular Ca 2+ concentration throughout whole volume, tracking microglia movement and microenvironmental changes following thermal injury in the zebrafish brain, analyzing structural and functional variations of gap junctions in astrocyte networks, and measuring the Ca 2+ concentration in neurons in mouse brains. This innovative methodology enables quantitative in vivo visualization of neurodynamics and the cellular processes and interactions in the brain.}, archive = {J_ADVS}, author = {Yanping Li and Xiangcong Xu and Chao Zhang and Xuefeng Sun and Sisi Zhou and Xuan Li and Jiaqing Guo and Rui Hu and Junle Qu and Liwei Liu}, doi = {10.1002/advs.202410605}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410605}, shortjournal = {Adv. Sci.}, title = {In vivo neurodynamics mapping via high-speed two-photon fluorescence lifetime volumetric projection microscopy}, volume = {12}, year = {2025}, }
• (2025). Co-delivery of aPD-l1 and CD73 inhibitor using calcium phosphate nanoparticles for enhanced melanoma immunotherapy with reduced toxicity. ADVS, 12(7), 2410545. (www)

  @article{ , abstract = {Melanoma, a malignant skin tumor, presents significant treatment challenges, particularly in unresectable and metastatic cases. While immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 have brought new hope, their efficacy is limited by low response rates and significant immune-mediated adverse events (irAEs). Through multi-omics data analysis, it is discovered that the spatial co-localization of CD73 and PD-L1 in melanoma correlates with improved progression-free survival (PFS), suggesting a synergistic potential of their inhibitors. Building on these insights, a novel therapeutic strategy using calcium phosphate (CaP) nanoparticles is developed for the co-delivery of aPD-L1 and APCP, a CD73 inhibitor. These nanoparticles, constructed via a biomineralization method, exhibit high drug-loading capacity and pH-responsive drug release. Compared to free aPD-L1, the CaP-delivered aPD-L1 effectively avoids systemic side effects while significantly enhancing anti-tumor efficacy, surpassing even a 20-fold dose of free aPD-L1. Furthermore, the co-delivery of aPD-L1 and APCP via CaP nanoparticles demonstrates a synergistic anti-tumor effect, with substantial immune activation and prevention of tumor recurrence through immune memory effects. These findings suggest that the co-delivery of aPD-L1 and APCP using CaP nanoparticles is a promising approach for improving melanoma immunotherapy, achieving enhanced efficacy and reduced toxicity.}, archive = {J_ADVS}, author = {Peng Liu and Jia Guo and Zuozhong Xie and Yusheng Pan and Benliang Wei and Ying Peng and Shuo Hu and Jinsong Ding and Xiang Chen and Juan Su and Hong Liu and Wenhu Zhou}, doi = {10.1002/advs.202410545}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410545}, shortjournal = {Adv. Sci.}, title = {Co-delivery of aPD-l1 and CD73 inhibitor using calcium phosphate nanoparticles for enhanced melanoma immunotherapy with reduced toxicity}, volume = {12}, year = {2025}, }
• (2025). Fabrication of polydopamine-coated high-entropy MXene nanosheets for targeted photothermal anticancer therapy. ADVS, 12(7), 2410537. (www)

  @article{ , abstract = {Transition metal carbides, nitrides, and carbonitrides (MXenes) have emerged as a promising class of 2D materials that can be used for various applications. Recently, a new form of high-entropy MXenes has been reported, which contains an increased number of elemental species that can increase the configurational entropy and reduce the Gibbs free energy. The unique structure and composition lead to a range of intriguing and tunable characteristics. Herein, the fabrication of high-entropy MXene TiVNbMoC 3 T x (T = surface terminations) with a layer of polydopamine is reported, followed by immobilization of a phthalocyanine-based fluorophore for imaging and the peptide sequence QRHKPREGGGSC for targeting the epidermal growth factor receptor (EGFR) overexpressed in cancer cells. The resulting nanocomposite exhibits high biocompatibility and superior photothermal property. Upon laser irradiation at 808 nm, the light-to-heat conversion efficiency is up to 56.1%, which is significantly higher than that of conventional 2D materials. In vitro studies show that these nanosheets could be internalized selectively into EGFR-positive cancer cells and effectively eliminate these cells mainly through photothermal-induced apoptosis. Using 4T1 tumor-bearing mice as an animal model, the nanosheets could accumulate at the tumor and effectively eradicate the tumor upon laser irradiation without causing noticeable adverse effects to the mice.}, archive = {J_ADVS}, author = {Qingshuang Zou and Ailin Qiu and Yan He and Evelyn Y. Xue and Lujie Wang and Gun Yang and Yao Shen and Dixian Luo and Quan Liu and Dennis K. P. Ng}, doi = {10.1002/advs.202410537}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410537}, shortjournal = {Adv. Sci.}, title = {Fabrication of polydopamine-coated high-entropy MXene nanosheets for targeted photothermal anticancer therapy}, volume = {12}, year = {2025}, }
• (2025). SENP6-mediated deSUMOylation of nrf2 exacerbates neuronal oxidative stress following cerebral ischemia and reperfusion injury. ADVS, 12(7), 2410410. (www)

  @article{ , abstract = {Oxidative stress is believed to play critical pathophysiological roles in ischemic brain injury, and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is recognized as the most crucial endogenous antioxidant stress damage route. Some research have demonstrated that Nrf2 play critical roles in oxidative stress after ischemic stroke, but the underlying mechanism are not fully elucidated. This study reveals that Nrf2 is modified by SUMOylation and identifies Sentrin/SUMO-specific protease 6 (SENP6) as a negative regulator of Nrf2 SUMOylation. Notably, SENP6 binds to and mediates the deSUMOylation of Nrf2, which in turn inhibits antioxidant response by enhancing ubiquitination-dependent degradation of Nrf2, thereby reducing its transcriptional activity, inducing oxidative stress and aggravating neuronal apoptosis after ischemic stroke. Additionally, blocking the interaction between SENP6 and Nrf2 with a cell membrane-permeable peptide (Tat-Nrf2) preserves the SUMOylation of Nrf2, effectively attenuates oxidative stress, and rescues neurological functions in mice subjected to ischemic stroke. Furthermore, no toxicity is observed when high doses Tat-Nrf2 are injected into nonischemic mice. Collectively, this study uncovers a previously unidentified mechanism whereby SUMOylation of Nrf2 regulates oxidative stress and strongly indicates that interventions targeting SENP6 or its interaction with Nrf2 may provide therapeutic benefits for ischemic stroke.}, archive = {J_ADVS}, author = {Qian Xia and Mengxin Que and Gaofeng Zhan and Longqing Zhang and Xue Zhang and Yilin Zhao and Huijuan Zhou and Lu Zheng and Meng Mao and Xing Li}, doi = {10.1002/advs.202410410}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410410}, shortjournal = {Adv. Sci.}, title = {SENP6-mediated deSUMOylation of nrf2 exacerbates neuronal oxidative stress following cerebral ischemia and reperfusion injury}, volume = {12}, year = {2025}, }
• (2025). Cilia-mimic locomotion of magnetic colloidal collectives enhanced by low-intensity ultrasound for thrombolytic drug penetration. ADVS, 12(7), 2410351. (www)

  @article{ , abstract = {Rapid thrombolysis is very important to reduce complications caused by vascular blockage. A promising approach for improving thrombolysis efficiency is utilizing the permanent magnetically actuated locomotion of nanorobots. However, the thrombolytic drug transportation efficiency is challenged by in-plane rotating locomotion and the insufficient drug penetration limits further improvement of thrombolysis. Inspired by ciliary movement for cargo transportation in human body, in this study, cilia-mimic locomotion of magnetic colloidal collectives is realized under torque-force vortex magnetic field (TFV-MF) by a designed rotating permanent magnet assembly. This cilia-mimic locomotion mode can generate more disturbances to the fluids to improve thrombolytic drug transportation and the increased height and area of colloidal collectives boosted the imaging capability. In addition, low-intensity ultrasound is applied to enhance colloids infiltration by producing the fiber breakage and inducing erythrocyte deformation. In vitro thrombolytic experiments demonstrate that the thrombolysis efficiency increased by 16.2 times compared with that of pure tissue plasminogen activator (tPA) treatments. Furthermore, in vivo rat models of femoral vein thrombosis confirmed that this approach can achieve blood flow recanalization more quickly. The proposed cilia-mimic locomotion of magnetic colloidal collectives combined with low-intensity ultrasound irradiation mode provides a new insight of therapeutic interventions for vascular thrombus by enhancing drug penetration.}, archive = {J_ADVS}, author = {Jingjing Wu and Weijuan Zou and Qijie Lu and Tingjia Zheng and Yanping Li and Tao Ying and Yuehua Li and Yuanyi Zheng and Longchen Wang}, doi = {10.1002/advs.202410351}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410351}, shortjournal = {Adv. Sci.}, title = {Cilia-mimic locomotion of magnetic colloidal collectives enhanced by low-intensity ultrasound for thrombolytic drug penetration}, volume = {12}, year = {2025}, }
• (2025). Multidimensional proteomic landscape reveals distinct activated pathways between human brain tumors. ADVS, 12(7), 2410142. (www)

  @article{ , abstract = {Brain metastases (BrMs) and gliomas are two typical human brain tumors with high incidence of mortalities and distinct clinical challenges, yet the understanding of these two types of tumors remains incomplete. Here, a multidimensional proteomic landscape of BrMs and gliomas to infer tumor-specific molecular pathophysiology at both tissue and plasma levels is presented. Tissue sample analysis reveals both shared and distinct characteristics of brain tumors, highlighting significant disparities between BrMs and gliomas with differentially activated upstream pathways of the PI3K-Akt signaling pathway that have been scarcely discussed previously. Novel proteins and phosphosites such as NSUN2, TM9SF3, and PRKCG_S330 are also detected, exhibiting a high correlation with reported clinical traits, which may serve as potential immunohistochemistry (IHC) biomarkers. Moreover, tumor-specific altered phosphosites and glycosites on FN1 are highlighted as potential therapeutic targets. Further validation of 110 potential noninvasive biomarkers yields three biomarker panels comprising a total of 19 biomarkers (including DES, VWF, and COL1A1) for accurate discrimination of two types of brain tumors and normal controls. In summary, this is a full-scale dataset of two typical human brain tumors, which serves as a valuable resource for advancing precision medicine in cancer patients through targeted therapy and immunotherapy.}, archive = {J_ADVS}, author = {Shuang Yang and Yongtao Zheng and Chengbin Zhou and Jun Yao and Guoquan Yan and Chengpin Shen and Siyuan Kong and Yueting Xiong and Qingfang Sun and Yuhao Sun and Huali Shen and Liuguan Bian and Kun Qian and Xiaohui Liu}, doi = {10.1002/advs.202410142}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410142}, shortjournal = {Adv. Sci.}, title = {Multidimensional proteomic landscape reveals distinct activated pathways between human brain tumors}, volume = {12}, year = {2025}, }
• (2025). Metabolic reprogramming of macrophages by biomimetic melatonin-loaded liposomes effectively attenuates acute gouty arthritis in a mouse model. ADVS, 12(7), 2410107. (www)

  @article{ , abstract = {Gouty arthritis is characterized by an acute inflammatory response triggered by monosodium urate (MSU) crystals deposited in the joints and periarticular tissues. Current treatments bring little effects owing to serious side effects, necessitating the exploration of new and safer therapeutic options. Macrophages play a critical role in the initiation, progression, and resolution of acute gout, with the cellular profiles closely linked to their activation and polarization. This suggests that metabolic regulation can be of significance in managing gouty inflammation. In this study, it is demonstrated that melatonin, a natural hormone, modulates the metabolic remodeling of inflammatory macrophages by shifting their metabolism from glycolysis to oxidative phosphorylation, further altering functions of the pathogenic macrophage. To improve melatonin delivery to the inflamed sites, macrophage membrane-coated melatonin-loaded liposomes (MLT-MLP) are developed. Benefiting from the inflammation-homing characteristic of macrophage membrane, such engineered liposomes effectively target the inflamed site and demonstrate potent anti-inflammatory effects, achieving an enhanced amelioration of acute gouty arthritis. In conclusion, this study proposes a novel strategy aimed at metabolic reprogramming of macrophages to attenuate the pathological injuries in acute gout, providing a potential therapeutic strategy of gout-associated diseases, especially gouty arthritis.}, archive = {J_ADVS}, author = {Chuchu Ma and Yuyu Jiang and Yan Xiang and Chang Li and Xiaoying Xie and Yunkai Zhang and Yang You and Laozhi Xie and Jianing Gong and Yinzhe Sun and Shiqiang Tong and Qingxiang Song and Jun Chen and Wenze Xiao}, doi = {10.1002/advs.202410107}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410107}, shortjournal = {Adv. Sci.}, title = {Metabolic reprogramming of macrophages by biomimetic melatonin-loaded liposomes effectively attenuates acute gouty arthritis in a mouse model}, volume = {12}, year = {2025}, }
• (2025). Structural repair of reduced graphene oxide promoted by single-layer graphene. ADVS, 12(7), 2410088. (www)

  @article{ , abstract = {High-temperature graphitization of graphene oxide (GO) is a crucial step for enhancing interlayer stacking and repairing the in-plane defects of reduced graphene oxide (rGO) films. However, the fine control of the structural repair and reducing the energy consumption in thermal treatment remain challenges. In this study, ab-initio molecular dynamics simulations combined with experiments are used to investigate the structural evolution of rGO upon thermal annealing, with or without the presence of single-layer graphene (SLG). It is found that the SLG promotes the repair of the carbon honeycombed matrix and alleviates the release of carbon-containing groups during graphitization. Further electronic analysis reveals the crucial role of charge transfer from SLG to defective graphene in strengthening the C─C bonds. The result of Raman spectroscopy matches with the simulation, demonstrating an improved repairing degree of rGO upon contacting with SLG. This study provides a deeper understanding of the graphitization and repair mechanism of rGO, which may be useful for the highly efficient preparation of high-quality graphene films.}, archive = {J_ADVS}, author = {Minghao Guo and Hong Yuan and Kun Ni and Chuanren Ye and Fei Pan and Juan Xiong and Yanwu Zhu}, doi = {10.1002/advs.202410088}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410088}, shortjournal = {Adv. Sci.}, title = {Structural repair of reduced graphene oxide promoted by single-layer graphene}, volume = {12}, year = {2025}, }
• (2025). Functional monomers equipped microgel system for managing parkinson's disease by intervening chemokine axis-mediated nerve cell communications. ADVS, 12(7), 2410070. (www)

  @article{ , abstract = {The complex pathology of Parkinson's disease (PD) requires comprehensive understanding and multi-pronged interventions for communication between nerve cells. Despite new developments in nanotechnology in the treatment of PD, in-depth exploration of their biological effects, in particular, the specific mechanisms of inflammation inhibition are lacking. Herein, using the stable cascade catalysis channel formed by polydopamine (PDA), imidazole groups, and Cu ions, a microgel system comprising functional monomers [superoxide dismutase (SOD) with double bonds, PDA, 2-methacryloyloxy ethyl phosphorylcholine (MPC), and Cu ions] is proposed for managing PD. The microgel can be efficiently delivered to the brain aided by MPC, after which a multi-level regulatory strategy targeting neurons and microglia can be initiated. The catalytic activity cascade elicited by SOD and Cu ions can regulate the anti-inflammatory phenotypic transformation of microglia by relieving oxidative stress. Meanwhile, the dopamine (DA) released from PDA can facilitate DA storage and neurogenesis, inhibiting CX3CL1 release and the CX3CR1 receptor on microglia and further regulating the CX3CL1/CX3CR1-NF-κB-NLRP3 signaling pathway in microglia to inhibit neuroinflammation. Therefore, the proposed microgel delivery system with functional monomers represents a promising therapeutic strategy for managing neuroinflammation and promoting neurogenesis in PD by intervening chemokine axis-mediated communication between neurons and microglia.}, archive = {J_ADVS}, author = {Lin Jiang and Xu Zhang and Shun Wang and Jiangkuan Zhang and Junyang Chen and Jiachuan Lu and Liting Yao and Weiwei Jin and Nan Li and Qing Li}, doi = {10.1002/advs.202410070}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410070}, shortjournal = {Adv. Sci.}, title = {Functional monomers equipped microgel system for managing parkinson's disease by intervening chemokine axis-mediated nerve cell communications}, volume = {12}, year = {2025}, }
• (2025). Nano-armed limosilactobacillus reuteri for enhanced photo-immunotherapy and microbiota tryptophan metabolism against colorectal cancer. ADVS, 12(7), 2410011. (www)

  @article{ , abstract = {Despite being a groundbreaking approach to treating colorectal cancer (CRC), the efficacy of immunotherapy is significantly compromised by the immunosuppressive tumor microenvironment and dysbiotic intestinal microbiota. Here, leveraging the superior carrying capacity and innate immunity-stimulating property of living bacteria, a nanomedicine-engineered bacterium, LR-S-CD/CpG@LNP, with optical responsiveness, immune-stimulating activity, and the ability to regulate microbiota metabolome is developed. Immunoadjuvant (CpG) and carbon dot (CD) co-loaded plant lipid nanoparticles (CD/CpG@LNPs) are constructed and conjugated to the surface of Limosilactobacillus reuteri (LR) via reactive oxygen species (ROS)-responsive linkers. The inherent photothermal and photodynamic properties of oral CD/CpG@LNPs induce in situ cytotoxic ROS generation and immunogenic cell death of colorectal tumor cells. The generated neoantigens and the released CpG function as a potent in situ vaccine that stimulates the maturation of immature dendritic cells. The mature dendritic cells and metabolites secreted by LR subsequently facilitated the tumor infiltration of cytotoxic T lymphocytes to eradicate colorectal tumors. The further in vivo results demonstrate that the photo-immunotherapy and intestinal microbial metabolite regulation of LR-S-CD/CpG@LNPs collectively suppressed the growth of orthotopic colorectal tumors and their liver metastases, presenting a promising avenue for synergistic treatment of CRC via the oral route.}, archive = {J_ADVS}, author = {Haiting Xu and Yajun Wang and Ga Liu and Zhenhua Zhu and Mohammad-Ali Shahbazi and Rui L. Reis and Subhas C. Kundu and Xiaoxiao Shi and Menghang Zu and Bo Xiao}, doi = {10.1002/advs.202410011}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2410011}, shortjournal = {Adv. Sci.}, title = {Nano-armed limosilactobacillus reuteri for enhanced photo-immunotherapy and microbiota tryptophan metabolism against colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Pyruvate kinase m2-responsive release of paclitaxel and indoleamine 2,3-dioxygenase inhibitor for immuno-chemotherapy of nonsmall cell lung cancer. ADVS, 12(7), 2409790. (www)

  @article{ , abstract = {Paclitaxel (PTX) is a first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC) but it can induce indoleamine 2,3-dioxygenase (IDO) activation, which severely lowers down its immuno-chemotherapeutic effect. To address this issue, a smart peptide hydrogelator Nap–Phe–Phe–Phe–Lys–Ser–Thr–Gly–Gly–Lys–Ala–Pro–Arg–OH ( Nap-T ), which co-assembles with PTX and an IDO inhibitor GDC0919 to form a hydrogel GP@Gel Nap-T, is rationally designed. Upon specific phosphorylation by pyruvate kinase M2 (PKM2), an overexpressed biomarker of NSCLC, Nap-T is gradually converted to Nap–Phe–Phe–Phe–Lys–Ser–Thr(H 2 PO 3 )–Gly–Gly–Lys–Ala–Pro–Arg–OH ( Nap-Tp ), leading to dehydrogelation and sustained release of PTX and GDC0919 within NSCLC tissues. The released PTX exerts chemotherapy on NSCLC cells as well as immunogenic cell death induction, while GDC0919 promotes the immuno-chemotherapeutic effect of PTX through IDO inhibition. We find that GP@Gel Nap-T enhances the infiltration of tumor-infiltrating immune cells and reduces the number of immunosuppressive cells in either tumor tissues or tumor-draining lymph nodes, thus enhancing the immuno-chemotherapy of PTX toward NSCLC. With this PKM2-responsive drug release strategy, the smart peptide hydrogel platform might be applied for NSCLC treatment in clinic in near future.}, archive = {J_ADVS}, author = {Haisi Wu and Xianbao Sun and Kaiming Li and Jinyu Li and Hui Jiang and Dan Yan and Ya Lin and Yan Ding and Yawen Lu and Xiaole Zhu and Xufeng Chen and Xiaolin Li and Gaolin Liang and Huae Xu}, doi = {10.1002/advs.202409790}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409790}, shortjournal = {Adv. Sci.}, title = {Pyruvate kinase m2-responsive release of paclitaxel and indoleamine 2,3-dioxygenase inhibitor for immuno-chemotherapy of nonsmall cell lung cancer}, volume = {12}, year = {2025}, }
• (2025). Neurotransmitter-mimicking nanovesicles facilitate postoperative glioblastoma stem cell-specific treatment for preventing tumor recurrence. ADVS, 12(7), 2409713. (www)

  @article{ , abstract = {Survival quality of glioblastoma (GBM) patients remains undesirable despite the aggressive multimodal treatment methods implemented, which are strongly associated with tumor recurrence after surgical resection. Self-renewal and strong tumourigenic capacity of glioblastoma stem cells (GSCs) at the narrow margin of the incision are essential factors driving tumor secondary strikes. Currently, the challenges in treating postoperative residual GSCs are mainly due to the lack of materials for incision and GSCs targeting. In this study, a neurotransmitter-mimicking nanovesicle (PMVS-P) based on platelet membrane-derived vesicle (PMV) with anti-GSC drug salinomycin (SAL)-loading and polydopamine (PDA)-surface is synthesized. PMVS-P exhibits surgical incision targeting ability and specifically identified GSCs with highly expressed D2 dopamine receptor (D2DR), a central nervous system neurotransmitter receptor, thus suppressing GBM recurrence. This neurotransmitter-mimicking nanovesicle primed GSC-specific tumoricidal treatment with broadened applications for preventing tumor recurrence.}, archive = {J_ADVS}, author = {Fuming Liang and Qing You and Bin Yu and Chen Wang and Yanlian Yang and Ling Zhu and Zhaohui He}, doi = {10.1002/advs.202409713}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409713}, shortjournal = {Adv. Sci.}, title = {Neurotransmitter-mimicking nanovesicles facilitate postoperative glioblastoma stem cell-specific treatment for preventing tumor recurrence}, volume = {12}, year = {2025}, }
• (2025). Tailoring ion transport in li3-3yHo1+yCl6-xBrx via transition-metal free structural planes and charge carrier distribution. ADVS, 12(7), 2409668. (www)

  @article{ , abstract = {Localized atomistic disorder in halide-based solid electrolytes (SEs) can be leveraged to boost Li + mobility. In this study, Li + transport in structurally modified Li 3 HoCl 6 , via Br − introduction and Li + deficiency, is explored. The optimized Li 3-3 y Ho 1+ y Cl 6- x Br x achieves an ionic conductivity of 3.8 mS cm −1 at 25 °C, the highest reported for holmium halide materials. 6,7 Li nuclear magnetic resonance and relaxometry investigations unveil enhanced ion dynamics with bromination, attaining a Li + motional rate neighboring 116 MHz. X-ray diffraction analyses reveal mixed-anion-induced phase transitions with disproportionate octahedral expansions and distortions, creating Ho-free planes with favorable energetics for Li + migration. Bond valence site energy analysis highlights preferred Li + transport pathways, particularly in structural planes devoid of Ho 3+ blocking effects. Molecular dynamics simulations corroborate enhanced Li + diffusion with Br − introduction into Li 3 HoCl 6 . Li-Ho electrostatic repulsions in the (001) plane presumably drive Li + diffusion into the Ho-free (002) layer, enabling rapid intraplanar Li + motion and exchange between the 2d and 4h sites. Li 3-3 y Ho 1+ y Cl 6- x Br x also demonstrates good battery cycling stability. These findings offer valuable insights into the intricate correlations between structure and ion transport and will help guide the design of high-performance fast ion conductors for all-solid-state batteries.}, archive = {J_ADVS}, author = {Bright O. Ogbolu and Tej P. Poudel and Thilina N. D. D. Dikella and Erica Truong and Yudan Chen and Dewen Hou and Tianyi Li and Yuzi Liu and Eric Gabriel and Hui Xiong and Chen Huang and Yan-Yan Hu}, doi = {10.1002/advs.202409668}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409668}, shortjournal = {Adv. Sci.}, title = {Tailoring ion transport in li3-3yHo1+yCl6-xBrx via transition-metal free structural planes and charge carrier distribution}, volume = {12}, year = {2025}, }
• (2025). Microplastics generate less mineral protection of soil carbon and more CO2 emissions. ADVS, 12(7), 2409585. (www)

  @article{ , abstract = {Microplastic pollution in terrestrial ecosystems threatens to destabilize large soil carbon stocks that help to mitigate climate change. Carbon-based substrates can release from microplastics and contribute to terrestrial carbon pools, but how these emerging organic compounds influence carbon mineralization and sequestration remains unknown. Here, microcosm experiments are conducted to determine the bioavailability of microplastic-derived dissolved organic matter (MP-DOM) in soils and its contribution to mineral-associated carbon pool. The underlying mechanisms are identified by estimating its spectroscopic and molecular signatures and comparing its sorption properties on model minerals with natural organic matter (NOM). The results show that MP-DOM leads to 21–576% higher CO 2 emissions and 34–83% lower mineral-associated organic carbon in soils than NOM, depending on the type of plastic polymer. DOM from biodegradable microplastics induces higher CO 2 emissions than conventional microplastics. It is found that MP-DOM is 7.96 times more labile than NOM, making it more accessible for microbial utilization. The lower degree of humification, fewer polar functional groups, and higher H/C ratios in MP-DOM also led to 3.96 times less sorption with mineral particles. The findings provide insights into the effects of microplastics on soil carbon storage and highlight their consequences for wider terrestrial carbon cycling and climate warming.}, archive = {J_ADVS}, author = {Jia Shi and Andrew J. Tanentzap and Yuanze Sun and Jianjun Wang and Baoshan Xing and Matthias C. Rillig and Changchao Li and Ling Jin and Fang Wang and Tanveer M. Adyel and Jianying Shang and Xiang Wang and Jie Wang}, doi = {10.1002/advs.202409585}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409585}, shortjournal = {Adv. Sci.}, title = {Microplastics generate less mineral protection of soil carbon and more CO2 emissions}, volume = {12}, year = {2025}, }
• (2025). One-pot synthesis of oxygen vacancy-rich Amorphous/Crystalline heterophase CaWO4 nanoparticles for enhanced radiodynamic-immunotherapy. ADVS, 12(7), 2409551. (www)

  @article{ , abstract = {Radiodynamic therapy that employs X-rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO 4 ) shows great potential as a radiodynamic agent benefiting from its strong X-ray absorption and the ability to generate electron–hole (e − -h + ) pairs, slow charge carrier transfer and fast e − -h + recombination greatly limit its ROS-generating performance. Herein, via a one-pot wet-chemical method, oxygen vacancy-rich amorphous/crystalline heterophase CaWO 4 nanoparticles (Ov-a/c-CaWO 4 NPs) with enhanced radiodynamic effect are synthesized for radiodynamic-immunotherapy of cancer. The phase composition and oxygen vacancy content of CaWO 4 can be easily tuned by adjusting the solvothermal temperature. More intriguingly, the amorphous/crystalline interfaces and abundant oxygen vacancies accelerate charge carrier transfer and suppress e − -h + recombination, respectively, enabling synergistically improved ROS production from X-ray-irradiated Ov-a/c-CaWO 4 NPs. In addition to directly inducing oxidative damage of cancer cells, radiodynamic generation of ROS also boosts immunogenic cell death to provoke a systemic antitumor immune response, thereby allowing the inhibition of both primary and distant tumors as well as cancer metastasis. This study establishes a synergistic enhancement strategy involving the integration of phase and defect engineering to improve the ROS generation capacity of radiodynamic-immunotherapeutic anticancer nanoagents.}, archive = {J_ADVS}, author = {Shanshan Peng and Zhen Chen and Jun Wang and Meili Yu and Xuegang Niu and Tingting Cui and Rujiang Ao and Huilan Cai and Hongwei Huang and Lisen Lin and Xiaoyuan Chen and Huanghao Yang}, doi = {10.1002/advs.202409551}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409551}, shortjournal = {Adv. Sci.}, title = {One-pot synthesis of oxygen vacancy-rich Amorphous/Crystalline heterophase CaWO4 nanoparticles for enhanced radiodynamic-immunotherapy}, volume = {12}, year = {2025}, }
• (2025). CXCL16/CXCR6/TGF-β feedback loop between M-MDSCs and treg inhibits anti-bacterial immunity during biofilm infection. ADVS, 12(7), 2409537. (www)

  @article{ , abstract = {Staphylococcus aureus (S. aureus) is a leading cause of Periprosthetic  joint  infection (PJI), a severe complication after joint arthroplasty. Immunosuppression is a major factor contributing to the infection chronicity of S. aureus PJI, posing significant treatment challenges. This study investigates the relationship between the immunosuppressive biofilm milieu and S. aureus PJI outcomes in both discovery and validation cohorts. This scRNA-seq analysis of synovium from PJI patients reveals an expansion and heightened activity of monocyte-related myeloid-derived suppressor cells (M-MDSCs) and regulatory T cells (Treg). Importantly, CXCL16 is significantly upregulated in M-MDSCs, with its corresponding CXCR6 receptor also elevated on Treg. M-MDSCs recruit Treg and enhance its activity via CXCL16-CXCR6 interactions, while Treg secretes TGF-β, inducing M-MDSCs proliferation and immunosuppressive activity. Interfering with this cross-talk in vivo using Treg-specific CXCR6 knockout PJI mouse model reduces M-MDSCs/Treg-mediated immunosuppression and alleviates bacterial burden. Immunohistochemistry and recurrence analysis show that PJI patients with CXCR6 high synovium have poor prognosis. This findings highlight the critical role of CXCR6 in Treg in orchestrating an immunosuppressive microenvironment and biofilm persistence during PJI, offering potential targets for therapeutic intervention.}, archive = {J_ADVS}, author = {Xiaoyu Wu and Baiqi Pan and Chenghan Chu and Yangchun Zhang and Jinjin Ma and Yang Xing and Yuanchen Ma and Wengang Zhu and Huan Zhong and Aerman Alimu and Guanming Zhou and Shuying Liu and Weishen Chen and Xiang Li and Sheng Puyi}, doi = {10.1002/advs.202409537}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409537}, shortjournal = {Adv. Sci.}, title = {CXCL16/CXCR6/TGF-β feedback loop between M-MDSCs and treg inhibits anti-bacterial immunity during biofilm infection}, volume = {12}, year = {2025}, }
• (2025). Itraconazole reversing acquired resistance to osimertinib in NSCLC by inhibiting the SHH/DUSP13B/p-STAT3 axis. ADVS, 12(7), 2409416. (www)

  @article{ , abstract = {There is an urgent necessity to devise efficient tactics to tackle the inevitable development of resistance to osimertinib, which is a third-generation epidermal growth factor receptor (EGFR) inhibitor used in treating EGFR-mutant nonsmall cell lung cancer (NSCLC). This study demonstrates that combining itraconazole with osimertinib synergistically reduces the proliferation and migration, enhances the apoptosis of osimertinib-resistant cells, and effectively inhibits the growth of osimertinib-resistant tumors. Mechanistically, itraconazole combined with osimertinib promotes the proteasomal degradation of sonic hedgehog (SHH), resulting in inactivation of the SHH/Dual-specificity phosphatase 13B (DUSP13B)/p-STAT3 and Hedgehog pathways, suppressing Myc proto-oncogene protein (c-Myc). Additionally, DUSP13B interacts with signal transducer and activator of transcription 3 (STAT3) and modulates its phosphorylation. Interestingly, it is observed that SHH overexpression partially rescues the synergistic effects of this combination treatment strategy through the SHH/DUSP13B/p-STAT3 signaling axis. Moreover, it is found that SHH, (GLI1), p-STAT3, and DUSP13B play significant predictive roles in osimertinib resistance. In lung adenocarcinoma, p-STAT3 is positively correlated with SHH but negatively correlated with DUSP13B. Together, these results highlight the crucial role of itraconazole in reversing the acquired resistance to osimertinib and provide a scientific rationale for the therapeutic strategy of combining osimertinib with itraconazole.}, archive = {J_ADVS}, author = {Hongmei Zheng and Yaoxiang Tang and Hongjing Zang and Jiadi Luo and Hanqiong Zhou and Yuting Zhan and Ying Zou and Qiuyuan Wen and Jian Ma and Songqing Fan}, doi = {10.1002/advs.202409416}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409416}, shortjournal = {Adv. Sci.}, title = {Itraconazole reversing acquired resistance to osimertinib in NSCLC by inhibiting the SHH/DUSP13B/p-STAT3 axis}, volume = {12}, year = {2025}, }
• (2025). Senescent fibroblasts drive FAP/OLN imbalance through mTOR signaling to exacerbate inflammation and bone resorption in periodontitis. ADVS, 12(7), 2409398. (www)

  @article{ , abstract = {Fibroblast activation protein (FAP), predominantly expressed in activated fibroblasts, plays a key role in inflammatory bone diseases, but its role in periodontitis remains unclear. Accordingly, this study identified a positive association between FAP levels and periodontitis susceptibility using Mendelian randomization analysis. Human and mouse periodontitis tissues show elevated FAP and reduced osteolectin (OLN), an endogenous FAP inhibitor, indicating a FAP/OLN imbalance. Single-cell RNA sequencing revealed gingival fibroblasts (GFs) as the primary FAP and OLN source, with periodontitis-associated GFs showing increased reactive oxygen species, cellular senescence, and mTOR pathway activation. Rapamycin treatment restored the FAP/OLN balance in GFs. Recombinant FAP increased pro-inflammatory cytokine secretion and osteoclast differentiation in macrophages, exacerbating periodontal damage, whereas FAP inhibition reduced macrophage inflammation, collagen degradation, and bone resorption in experimental periodontitis. Therefore, senescent fibroblasts drive the FAP/OLN imbalance through mTOR activation, contributing to periodontitis progression. Consequently, targeting FAP may offer a promising therapeutic strategy for periodontitis.}, archive = {J_ADVS}, author = {Chenghu Yin and Liangliang Fu and Shuling Guo and Youde Liang and Taizhi Shu and Wenjun Shao and Haibin Xia and Ting Xia and Min Wang}, doi = {10.1002/advs.202409398}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409398}, shortjournal = {Adv. Sci.}, title = {Senescent fibroblasts drive FAP/OLN imbalance through mTOR signaling to exacerbate inflammation and bone resorption in periodontitis}, volume = {12}, year = {2025}, }
• (2025). A modular engineered DNA nanodevice for precise profiling of telomerase RNA location and activity. ADVS, 12(7), 2409344. (www)

  @article{ , abstract = {Increased telomerase activity has been considered as a conspicuous sign of human cancers. The catalytic cores of telomerase involve a reverse transcriptase and the human telomerase RNA (hTR). However, current detection of telomerase is largely limited to its activity at the tissue and single-cell levels. To reveal the precise distribution of subcellular hTR and telomerase activity, here a modular engineered DNA nanodevice (DNA-ND) is designed capable of imaging hTR and telomerase activity in cytoplasm and nucleus, enabling colocalization analysis. DNA-ND is a modular DNA complex comprising hTR and telomerase activity detection modules, which respectively sense intercellular hTR and telomerase activity via target-sensitive allosteric transition of DNA switches, actuating orthogonal activation of fluorescence signals to achieve in situ co-imaging of hTR and telomerase activity. By integrating DNA-ND with specific localized signals, the DNA-ND based precise profiling of colocalization of hTR and telomerase activity in different cell lines as well as their dynamic changes during pharmacological interventions is demonstrated. Notably, the results suggest that the locations of hTR and telomerase activity are not exactly overlapped, indicating the influence of intracellular environment on the binding of hTR to telomerase.}, archive = {J_ADVS}, author = {Shi-Yi Zhang and Jian Lv and Ze-Rui Zhou and Peter X. Geng and Da-Wei Li and Ruo-Can Qian and Huangxian Ju}, doi = {10.1002/advs.202409344}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409344}, shortjournal = {Adv. Sci.}, title = {A modular engineered DNA nanodevice for precise profiling of telomerase RNA location and activity}, volume = {12}, year = {2025}, }
• (2025). Targeting metabolic adaptation of colorectal cancer with vanadium-doped nanosystem to enhance chemotherapy and immunotherapy. ADVS, 12(7), 2409329. (www)

  @article{ , abstract = {The anti-tumor efficacy of current pharmacotherapy is severely hampered due to the adaptive evolution of tumors, urgently needing effective therapeutic strategies capable of breaking such adaptability. Metabolic reprogramming, as an adaptive survival mechanism, is closely related to therapy resistance of tumors. Colorectal cancer (CRC) cells exhibit a high energy dependency that is sustained by an adaptive metabolic conversion between glucose and glutamine, helping tumor cells to withstand nutrient-deficient microenvironments and various treatments. We discover that transition metal vanadium (V) effectively inhibits glucose metabolism in CRC and synergizes with glutaminase inhibitors (BPTES) to disrupt CRC's energy dependency. Thus, a dual energy metabolism suppression nanosystem (VSi-BP@HA) is engineered by loading BPTES into V-doped hollow mesoporous silica nanoparticles. This nanosystem effectively dampens CRC energy metabolism, eradicating 33% of tumors in mice. Strikingly, the cell biological and preclinical model datasets provide compelling evidence showing that VSi-BP@HA not only reverses CRC cells chemo-resistance but also drastically potentiates anti-PD1 immunotherapy. Therefore, this nanosystem provides not only a promising approach to suppress CRC, but also a potential adjunct tool for enhancing chemotherapy and immunotherapy.}, archive = {J_ADVS}, author = {Qian Cheng and Yuzhe Chen and Danyi Zou and Qilin Li and Xiaolei Shi and Qushuhua Qin and Miaodeng Liu and Lin Wang and Zheng Wang}, doi = {10.1002/advs.202409329}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409329}, shortjournal = {Adv. Sci.}, title = {Targeting metabolic adaptation of colorectal cancer with vanadium-doped nanosystem to enhance chemotherapy and immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Recent advances in strategies to enhance photodynamic and photothermal therapy performance of single-component organic phototherapeutic agents. ADVS, 12(7), 2409157. (www)

  @article{ , abstract = {Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic and nononcologic diseases. Single-component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, and enhanced reproducibility. Nonetheless, how to further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies to improve the performance of PDT or PTT by optimizing the structural design of SCOPAs. These strategies encompass augmenting reactive oxygen species (ROS) generation, mitigating oxygen dependence, elevating light absorption capacity, broadening the absorption region, and enhancing the photothermal conversion efficiency (PCE). Additionally, this review also underscores the ideal strategies for developing SCOPAs with balanced PDT and PTT. Furthermore, the potential synergies are highlighted between PDT and PTT with other treatment modalities such as ferroptosis, gas therapy, chemotherapy, and immunotherapy. By providing a comprehensive analysis of these strategies, this review aspires to serve as a valuable resource for clinicians and researchers, facilitating the wider application and advancement of SCOPAs-mediated PDT and PTT.}, archive = {J_ADVS}, author = {Laiping Fang and Zengzhen Chen and Jianan Dai and Yujin Pan and Yike Tu and Qi Meng and Yanzhao Diao and Shuaibo Yang and Wei Guo and Liming Li and Jinwu Liu and Hua Wen and Kelei Hua and Lifeng Hang and Jin Fang and Xianwei Meng and Ping'an Ma and Guihua Jiang}, doi = {10.1002/advs.202409157}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409157}, shortjournal = {Adv. Sci.}, title = {Recent advances in strategies to enhance photodynamic and photothermal therapy performance of single-component organic phototherapeutic agents}, volume = {12}, year = {2025}, }
• (2025). Super-enhancer activates master transcription factor NR3C1 expression and promotes 5-FU resistance in gastric cancer. ADVS, 12(7), 2409050. (www)

  @article{ , abstract = {Poor response to 5-fluorouracil (5-FU) remains an obstacle in the treatment of gastric cancer (GC). Super enhancers (SEs) are crucial for determining tumor cell survival under drug pressure. SE landscapes related to 5-FU-resistance are mapped to GC using chromatin immunoprecipitation-sequencing (ChIP-Seq). SiRNA transcription factors (TFs) screen determines master TF Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1) activated by SE. High NR3C1 expression driven by SE correlated with 5-FU resistance in patient-derived organoids (PDOs). Phase separation formed by NR3C1 is observed using fluorescence recovery after photobleaching (FRAP). NR3C1 protein and Mediator promoted SE-related gene transcription via phase separation. SEs and NR3C1 co-binding patterns are explored using Cleavage Under Targets and Tagmentation (CUT&Tag) sequencing. 5-FU-related genes driven by NR3C1 are identified using epigenetic reader inhibitor JQ1 and NR3C1 specific inhibitor Cort108297. NR3C1 knockdown increases 5-FU sensitivity and alters the SE landscape through enhancer reprogramming, reducing downstream 5-FU-related target genes. JQ1 and Cort108297 both improve 5-FU efficacy in PDOs and patient-derived xenografts (PDXs) by destroying SEs or inhibiting NR3C1. In conclusion, SE-driven NR3C1 promotes 5-FU resistance in GC. SE destruction and NR3C1 inhibition lead to enhancer reconstruction and reduce 5-FU-related gene transcription, providing alternative therapeutic strategies for improving 5-FU sensitivity.}, archive = {J_ADVS}, author = {Junxian Yu and Mengdi Chen and Qingqing Sang and Fangyuan Li and Zhuoqing Xu and Beiqin Yu and Changyu He and Liping Su and Wentao Dai and Chao Yan and Zheng-gang Zhu and Jiazeng Xia and Jianfang Li and Haoran Feng and Yunqin Chen and Yuan-Yuan Li and Bingya Liu}, doi = {10.1002/advs.202409050}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2409050}, shortjournal = {Adv. Sci.}, title = {Super-enhancer activates master transcription factor NR3C1 expression and promotes 5-FU resistance in gastric cancer}, volume = {12}, year = {2025}, }
• (2025). Aneurysm is restricted by CD34+ cell-formed fibrous collars through the PDGFRb-PI3K axis. ADVS, 12(7), 2408996. (www)

  @article{ , abstract = {Aortic aneurysm is a life-threatening disease caused by progressive dilation of the aorta and weakened aortic walls. Its pathogenesis involves an imbalance between connective tissue repair and degradation. CD34 + cells comprise a heterogeneous population that exhibits stem cell and progenitor cell properties. However, the role of CD34 + cells in abdominal aortic aneurysm (AAA) remains unclear. In this study, downregulated CD34 expression is observed in aneurysmal aortas from both patients and mouse models compared to that in non-dilated aortas. Furthermore, by combining Cd34 -CreER T2 ;Rosa26-tdTomato;( Apoe −/− ) lineage tracing, bone marrow transplantation, and single-cell sequencing, it is found that during AAA development, non-bone marrow CD34 + cells are activated to transdifferentiate into Periostin + myofibroblasts, thereby contributing to the formation of fibrotic collars. Dual recombinase-based lineage tracing confirms the presence and involvement of CD34 + /Periostin + myofibroblasts in fibrotic collar formation during AAA development. Functionally, selective depletion of systemic or non-bone marrow CD34 + cells, as well as CD34 + /Periostin + myofibroblasts, by diphtheria toxin significantly exacerbates AAA progression and increases disease mortality. Mechanistically, it is identified that the PDGF-PDGFRb-PI3K axis is indispensable for Periostin + myofibroblast generation from non-bone marrow CD34 + cells in AAA, offering a new therapeutic target for patients with AAA at a high risk of rupture.}, archive = {J_ADVS}, author = {Hong Wu and Xiaoping Yang and Ting Chen and Baoqi Yu and Mengjia Chen and Ting Wang and Liujun Jiang and Bohuan Zhang and Xuhao Zhou and Junning Cheng and Kai Chen and Tao Zhang and Yanhua Hu and Simon Xu and Jiangfang Lian and Hongkun Zhang and Qingzhong Xiao and Honghua Ye and Qingbo Xu}, doi = {10.1002/advs.202408996}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2408996}, shortjournal = {Adv. Sci.}, title = {Aneurysm is restricted by CD34+ cell-formed fibrous collars through the PDGFRb-PI3K axis}, volume = {12}, year = {2025}, }
• (2025). Chromatin topological domains associate with the rapid formation of tandem duplicates in plants. ADVS, 12(7), 2408861. (www)

  @article{ , abstract = {In eukaryotes, chromatin is compacted within nuclei under the principle of compartmentalization. On top of that, condensin II establishes eukaryotic chromosome territories, while cohesin organizes the vertebrate genome by extruding chromatin loops and forming topologically associating domains (TADs). Thus far, the formation and roles of these chromatin structures in plants remain poorly understood. This study integrates Hi-C data from diverse plant species, demonstrating that nuclear DNA content influences large-scale chromosome conformation and affects the finer details of compartmental patterns. These contrasting compartmental patterns are distinguished by gene-to-gene loops and validated through cytological observations. Additionally, a novel chromatin domain type associated with tandem duplicate gene clusters is identified. These domains are independent of H3K27me3-mediated chromatin compartmentalization and exhibit evolutionary conservation across species. Gene pairs within TAD-like domains are younger and show higher levels of coexpression. These domains potentially promote the formation of tandem duplicates, a property appears unique to the Actinidia family. Overall, this study reveals functional chromatin domains in plants and provides evidence for the role of three-dimensional chromatin architecture in gene regulation and genome evolution.}, archive = {J_ADVS}, author = {Ni Ma and Xiaopeng Li and Dong Ci and Hai Yue Zeng and Congxiao Zhang and Xiaodong Xie and Caihong Zhong and Xing Wang Deng and Dawei Li and Hang He}, doi = {10.1002/advs.202408861}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2408861}, shortjournal = {Adv. Sci.}, title = {Chromatin topological domains associate with the rapid formation of tandem duplicates in plants}, volume = {12}, year = {2025}, }
• (2025). Inhibition of endoplasmic reticulum stress cooperates with SLC7A11 to promote disulfidptosis and suppress tumor growth upon glucose limitation. ADVS, 12(7), 2408789. (www)

  @article{ , abstract = {Disulfidptosis is a newly discovered type of regulated cell death triggered by disulfide bond accumulation and NADPH (nicotinamide adenine dinucleotide phosphate) depletion due to glucose deprivation. However, the regulatory mechanisms involving additional cellular circuits remain unclear. Excessive disulfide bond accumulation can impair endoplasmic reticulum (ER) homeostasis and activate the ER stress response. In this study, we found that SLC7A11-mediated disulfidptosis upon glucose deprivation is accompanied by ER stress induction. Pharmacological inhibition of SLC7A11-mediated cystine uptake or cystine withdrawal not only blocks disulfidptosis under glucose starvation but also suppresses the ER stress response, indicating a close link between these processes. Moreover, inhibitors targeting the ER stress response promote disulfidptosis, while ER stress inducers suppress glucose starvation-induced disulfidptosis in SLC7A11-high-expressing cells, suggesting a protective role for ER stress during disulfidptosis. Similar effects are observed in cells treated with glucose transporter inhibitors (GLUTi). Finally, combined treatment with ER stress inhibitors and GLUTi significantly suppresses tumor growth both in vitro and in vivo by inducing disulfide stress and subsequent disulfidptosis. In summary, these findings reveal a novel role for ER stress in regulating disulfidptosis and provide theoretical insights into the potential application of GLUTi and ER stress inhibitors in cancer therapy.}, archive = {J_ADVS}, author = {Jin Wang and Jing Chen and Kexin Fan and Minglin Wang and Min Gao and Yakun Ren and Shaobo Wu and Qian He and Kangsheng Tu and Qiuran Xu and Yilei Zhang}, doi = {10.1002/advs.202408789}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2408789}, shortjournal = {Adv. Sci.}, title = {Inhibition of endoplasmic reticulum stress cooperates with SLC7A11 to promote disulfidptosis and suppress tumor growth upon glucose limitation}, volume = {12}, year = {2025}, }
• (2025). Hepatocyte-derived FGF1 alleviates isoniazid and rifampicin-induced liver injury by regulating HNF4α-mediated bile acids synthesis. ADVS, 12(7), 2408688. (www)

  @article{ , abstract = {Isoniazid and rifampicin co-therapy are the main causes of anti-tuberculosis drug-induced liver injury (ATB-DILI) and acute liver failure, seriously threatening human health. However, its pathophysiology is not fully elucidated. Growing evidences have shown that fibroblast growth factors (FGFs) play a critical role in diverse aspects of liver pathophysiology. The aim of this study is to investigate the role of FGFs in the pathogenesis of isoniazid (INH) and rifampicin (RIF)-induced liver injury. Through systematic screening, this study finds that hepatic FGF1 expression is significantly downregulated in both mouse model and human patients challenged with INH and RIF. Hepatocyte-specific Fgf1 deficiency exacerbates INH and RIF-induced liver injury resulted from elevated bile acids (BAs) synthases and aberrant BAs accumulation. Conversely, pharmacological administration of the non-mitogenic FGF1 analog – FGF1 ΔHBS significantly alleviated INH and RIF-induced liver injury via restoring BAs homeostasis. Mechanically, FGF1 repressed hepatocyte nuclear factor 4 α ( Hnf4α ) transcription via activating FGF receptor 4 (FGFR4)-ERK1/2 signaling pathway, thus reducing BAs synthase. The findings demonstrate hepatic FGF1 functions as a negative regulator of BAs biosynthesis to protect against INH and RIF-induced liver injury via normalizing hepatic BAs homeostasis, providing novel mechanistic insights into the pathogenesis of ATB-DILI and potential therapeutic strategies for treatment of ATB-DILI.}, archive = {J_ADVS}, author = {Qian Lin and Jiaren Zhang and Jie Qi and Jialin Tong and Shenghuan Chen and Sudan Zhang and Xingru Liu and Huatong Lou and Jiaxuan Lv and Ruoyu Lin and Junjun Xie and Yi Jin and Yang Wang and Lei Ying and Jiamin Wu and Jianlou Niu}, doi = {10.1002/advs.202408688}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2408688}, shortjournal = {Adv. Sci.}, title = {Hepatocyte-derived FGF1 alleviates isoniazid and rifampicin-induced liver injury by regulating HNF4α-mediated bile acids synthesis}, volume = {12}, year = {2025}, }
• (2025). Support-free, connected Core–Shell nanoparticle catalysts synthesized via a low-temperature process for advanced oxygen reduction performance. ADVS, 12(7), 2408614. (www)

  @article{ , abstract = {Nanostructured Pt-based catalysts have attracted considerable attention for fuel-cell applications. This study introduces a novel one-pot and low-temperature polyol approach for synthesizing support-free, connected nanoparticles with non-Pt metal cores and Pt shells. Unlike conventional heat treatment methods, the developed support-free and Fe-free connected Pd core @Pt shell (Pd@Pt) nanoparticle catalyst possesses a stable nanonetwork structure with a high surface area. This approach can precisely control the atomic-level structure of the Pt shell on the Pd core at a low deposition temperature. The optimized Pd@Pt catalyst with a Pt/Pd atomic ratio of 0.8 and a Pt shell thickness of 1.1 nm exhibits a threefold improvement in oxygen reduction reaction (ORR) mass activity compared to that of commercial carbon-supported Pt nanoparticle catalyst (Pt/C). Durability evaluation demonstrated 100% retention of specific activity after 10,000 load cycles, owing to the stable nanonetwork and uniform coverage of the Pt shell. In addition, the support-free, connected core–shell nanoparticle catalyst overcomes the carbon corrosion issues commonly associated with conventional carbon-supported catalysts while simultaneously improving both ORR activity and load cycle durability. These findings highlight the potential of this innovative approach to develop support-free catalysts for polymer electrolyte fuel cells and other energy devices.}, archive = {J_ADVS}, author = {Aparna Chitra Sudheer and Gopinathan M. Anilkumar and Hidenori Kuroki and Takeo Yamaguchi}, doi = {10.1002/advs.202408614}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2408614}, shortjournal = {Adv. Sci.}, title = {Support-free, connected Core–Shell nanoparticle catalysts synthesized via a low-temperature process for advanced oxygen reduction performance}, volume = {12}, year = {2025}, }
• (2025). Targeting deltex e3 ubiquitin ligase 2 inhibits tumor-associated neutrophils and sensitizes hepatocellular carcinoma cells to immunotherapy. ADVS, 12(7), 2408233. (www)

  @article{ , abstract = {Several E3 ligases have been found to affect the immune microenvironment of hepatocellular carcinoma (HCC) and lead to the resistance of immunotherapy. In this study, genes of E3 ligases are screened based on The Cancer Genome Atlas (TCGA) dataset. Through cytometry by time of flight (CyTOF), flow cytometry, and further experiments, Deltex E3 ubiquitin ligase 2 (DTX2) in HCC cells is identified to promote the infiltration and polarization of tumor-associated neutrophils (TANs) with a protumor phenotype, thus attenuating the infiltration and cytotoxicity of CD8+ T cells partially through C-X-C motif chemokine 2 (CXCL2) and C-X-C motif chemokine 6 (CXCL6). Mechanistically, DTX2 can interact with histone H2B and promote its monoubiquitination at lysine120 (H2BK120ub1), thereby increasing CXCL2 and CXCL6 transcription through histone epigenetic regulation. Different tumor models in vivo demonstrated that DTX2 inhibitor treatment inhibited tumor growth and sensitized HCC cells to the therapeutic effects of programmed cell death protein 1 (PD-1) antibody. In summary, this study identifies DTX2 as a potential target for HCC immunotherapy.}, archive = {J_ADVS}, author = {Xiaoling Wu and Jiafeng Chen and Yiran Chen and Shushu Song and Yuan Fang and Shengwei Mao and Jun Gao and Guiqi Zhu and Weifeng Qu and Qianfu Zhao and Rui Yang and Zhiqi Guan and Tianhao Chu and Yichao Bu and Yi Wang and Fangyu Chen and Jian Zhou and Jia Fan and Zheng Tang and Weiren Liu and Yuanyuan Ruan and Yinghong Shi}, doi = {10.1002/advs.202408233}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2408233}, shortjournal = {Adv. Sci.}, title = {Targeting deltex e3 ubiquitin ligase 2 inhibits tumor-associated neutrophils and sensitizes hepatocellular carcinoma cells to immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Concurrent amplification of ferroptosis and immune system activation via nanomedicine-mediated radiosensitization for triple-negative breast cancer therapy. ADVS, 12(7), 2407833. (www)

  @article{ , abstract = {Radiation therapy (RT) is one of the core therapies for current cancer management. However, the emergence of radioresistance has become a major cause of radiotherapy failure and disease progression. Therefore, overcoming radioresistance to achieve highly effective treatment for refractory tumors is significant yet challenging. Here, pH-responsive DSPE-PEoz modified hollow Bi 2 Se 3 -RSL3/diABZi (DP-HBN/RA) nanomedicine is designed as a radiation sensitizer for efficient treatment of triple-negative breast cancer by simultaneously amplifying ferroptosis and immune system activation. DP-HBN/RA can efficiently concentrate X-ray radiation energy inside the tumor, thereby promoting precise ionizing radiation exposure in tumor cells to produce large amounts of reactive oxygen species (ROS), leading to lipid peroxidation-induced ferroptosis. Meanwhile, ferroptotic cell death is intensified through the inactivation of GPX4 by RSL3 released from DP-HBN/RA to acidic conditions in the tumor microenvironment. Additionally, DP-HBN/RA enhances RT efficacy to exacerbate unrepairable DNA damage and release DNA fragments that activate the cGAS-STING signal pathway, evoking a systematic immune response. Ingeniously, the released diABZi reinforces cGAS-STING activation to boost the immunology antitumor effect. This work links the induction of ferroptosis and the initiation of systematic immune response to achieve highly effective tumor suppression, which opens up new avenues for future treatments of refractory tumors.}, archive = {J_ADVS}, author = {Reyida Aishajiang and Zhongshan Liu and Yuan Liang and Pengye Du and Yi Wei and Xiqian Zhuo and Shuyu Liu and Pengpeng Lei and Tiejun Wang and Duo Yu}, doi = {10.1002/advs.202407833}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2407833}, shortjournal = {Adv. Sci.}, title = {Concurrent amplification of ferroptosis and immune system activation via nanomedicine-mediated radiosensitization for triple-negative breast cancer therapy}, volume = {12}, year = {2025}, }
• (2025). Fatty acid oxidation-glycolysis metabolic transition affects ECM homeostasis in silica-induced pulmonary fibrosis. ADVS, 12(7), 2407134. (www)

  @article{ , abstract = {Silicosis is a fatal occupational pulmonary disease that is characterized by irreversible replacement of lung parenchyma by aberrant Exracellular matrix (ECM). Metabolic reprogramming is a crucial mechanism for fibrosis. However, how the metabolic rewiring shifts the ECM homeostasis toward overaccumulation remains unclear. Herein, a phenotype with reduction in fatty acid oxidation (FAO) but enhanced glycolysis in myofibroblasts is shown. Perturbation of the glycolytic and FAO pathways, respectively, reveals distinct roles in the metabolic distribution of ECM deposition and degradation. Suppressed glycolysis leads to a decrease in insoluble ECM, primarily due to the inhibition of ECM-modifying enzyme activity and a decrease in glycine synthesis. Notably, promoted FAO facilitates the intracellular degradation pathway of ECM. In addition, the findings revealed that hypoxia-inducible factor-1 alpha (HIF-1α) serves as a crucial metabolic regulator in the transition from FAO to glycolysis, thereby playing a significant role in ECM deposition in silica-induced pulmonary fibrosis. Further, the promotion of FAO, inhibition of glycolysis and HIF-1α reduce ECM production and promote ECM degradation, ultimately impeding the progression of fibrosis and providing therapeutic relief for established pulmonary fibrosis in vivo. These findings unveil the metabolic rewire underpinning the deposition of ECM in silica-induced lung fibrosis and identify novel targets for promoting regression of pulmonary fibrosis.}, archive = {J_ADVS}, author = {Wenqing Sun and Siyun Zhou and Lan Peng and Wei Wang and Yi Liu and Ting Wang and Demin Cheng and Ziwei Li and Haojie Xiong and Xinying Jia and Wenxiu Lian and Jiandong Jiao and Chunhui Ni}, doi = {10.1002/advs.202407134}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2407134}, shortjournal = {Adv. Sci.}, title = {Fatty acid oxidation-glycolysis metabolic transition affects ECM homeostasis in silica-induced pulmonary fibrosis}, volume = {12}, year = {2025}, }
• (2025). Lactylation of histone h3k18 and egr1 promotes endothelial glycocalyx degradation in sepsis-induced acute lung injury. ADVS, 12(7), 2407064. (www)

  @article{ , abstract = {Circulating lactate is a critical biomarker for sepsis-induced acute lung injury (S-ALI) and is strongly associated with poor prognosis. However, whether elevated lactate directly promotes S-ALI and the specific mechanism involved remain unclear. Here, this work shows that lactate causes pulmonary endothelial glycocalyx degradation and worsens ALI during sepsis. Mechanistically, lactate increases the lactylation of K18 of histone H3, which is enriched at the promoter of EGR1 and promotes its transcription, leading to upregulation of heparanase in pulmonary microvascular endothelial cells. In addition, multiple lactylation sites are identified in EGR1, and lactylation is confirmed to occur mainly at K364. K364 lactylation of EGR1 facilitates its interaction with importin-α, in turn promoting its nuclear localization. Importantly, this work identifies KAT2B as a novel lactyltransferase whose GNAT domain directly mediates the lactylation of EGR1 during S-ALI. In vivo, suppression of lactate production or genetic knockout of EGR1 mitigated glycocalyx degradation and ALI and improved survival outcomes in mice with polymicrobial sepsis. Therefore, this study reveals that the crosstalk between metabolic reprogramming in endothelial cells and epigenetic modifications plays a critical role in the pathological processes of S-ALI.}, archive = {J_ADVS}, author = {Zongqing Lu and Pu Fang and Shuai Li and Dunling Xia and Jingjing Zhang and Xianghui Wu and Jingjing Pan and Haijian Cai and Lin Fu and Gengyun Sun and Qinghai You}, doi = {10.1002/advs.202407064}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2407064}, shortjournal = {Adv. Sci.}, title = {Lactylation of histone h3k18 and egr1 promotes endothelial glycocalyx degradation in sepsis-induced acute lung injury}, volume = {12}, year = {2025}, }
• (2025). SAM-dPCR: Accurate and generalist nuclei acid quantification leveraging the zero-shot segment anything model. ADVS, 12(7), 2406797. (www)

  @article{ , abstract = {Digital PCR (dPCR) has transformed nucleic acid diagnostics by enabling the absolute quantification of rare mutations and target sequences. However, traditional dPCR detection methods, such as those involving flow cytometry and fluorescence imaging, may face challenges due to high costs, complexity, limited accuracy, and slow processing speeds. In this study, SAM-dPCR is introduced, a training-free open-source bioanalysis paradigm that offers swift and precise absolute quantification of biological samples. SAM-dPCR leverages the robustness of the zero-shot Segment Anything Model (SAM) to achieve rapid processing times (<4 seconds) with an accuracy exceeding 97.10%. This method has been extensively validated across diverse samples and reactor morphologies, demonstrating its broad applicability. Utilizing standard laboratory fluorescence microscopes, SAM-dPCR can measure nucleic acid template concentrations ranging from 0.154 copies µL −1 to 1.295 × 10 3 copies µL −1 for droplet dPCR and 0.160 × 10 3 to 3.629 × 10 3 copies µL −1 for microwell dPCR. Experimental validation shows a strong linear relationship (r 2 > 0.96) between expected and determined sample concentrations. SAM-dPCR offers high accuracy, accessibility, and the ability to address bioanalytical needs in resource-limited settings, as it does not rely on hand-crafted “ground truth” data.}, archive = {J_ADVS}, author = {Yuanyuan Wei and Shanhang Luo and Changran Xu and Yingqi Fu and Yi Zhang and Fuyang Qu and Guoxun Zhang and Yi-Ping Ho and Ho-Pui Ho and Wu Yuan}, doi = {10.1002/advs.202406797}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2406797}, shortjournal = {Adv. Sci.}, title = {SAM-dPCR: Accurate and generalist nuclei acid quantification leveraging the zero-shot segment anything model}, volume = {12}, year = {2025}, }
• (2025). OTUD5 protects dopaminergic neurons by promoting the degradation of α-synuclein in parkinson's disease model. ADVS, 12(7), 2406700. (www)

  @article{ , abstract = {Defective clearance and accumulation of α-synuclein (α-Syn) is the key pathogenic factor in Parkinson's disease (PD). Recent studies emphasize the importance of E3 ligases in regulating the degradation of α-Syn. However, the molecular mechanisms by which deubiquitinases regulate α-Syn degradation are scarcely studied. In this study, it is found that the protein levels of α-Syn are negatively regulated by ovarian tumor protease deubiquitinase 5 (OTUD5) which protects dopaminergic (DA) neurons in the PD model. Mechanistically, OTUD5 promotes K63-linked polyubiquitination of α-Syn independent of its deubiquitinating enzyme activity and mediates its endolysosomal degradation by recruiting the E3 ligase neural precursor cell expressed developmentally downregulated 4 (NEDD4). Furthermore, OTUD5 conditional knockout in DA neurons results in more severe α-Syn related pathology and dyskinesia after injection of α-Syn preformed fibrils (PFF). Overall, the data unveil a novel mechanism to regulate the degradation of α-Syn and provide a new therapeutic strategy to alleviate DA neurodegeneration.}, archive = {J_ADVS}, author = {Xiaomeng Song and Tengfei Liu and Lu Yu and Qiuran Ji and Xin Guo and Runzhe Zong and Yiquan Li and Gan Huang and Qidi Xue and Qingyi Fu and Bingyu Liu and Yi Zheng and Lin Chen and Chengjiang Gao and Huiqing Liu}, doi = {10.1002/advs.202406700}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2406700}, shortjournal = {Adv. Sci.}, title = {OTUD5 protects dopaminergic neurons by promoting the degradation of α-synuclein in parkinson's disease model}, volume = {12}, year = {2025}, }
• (2025). Robotic laser tissue soldering for atraumatic soft tissue fusion guided by fluorescent nanothermometry. ADVS, 12(7), 2406671. (www)

  @article{ , abstract = {Minimally invasive surgical techniques, including endoscopic and robotic procedures, continue to revolutionize patient care, for their ability to minimize surgical trauma, thus promoting faster recovery and reduced hospital stays. Yet, the suturing of soft tissues ensuring damage-free tissue bonding during these procedures remains challenging due to missing haptics and the fulcrum effect. Laser tissue soldering has potential in overcoming these issues, offering atraumatic seamless tissue fusion. To ensure the precision and safety of laser tissue soldering, the study introduces feedback-controlled fluorescent nanothermometry-guided laser tissue soldering using nanoparticle-protein solders within endoscopic and robotic contexts. Temperature-sensitive fluorescent nanoparticles embedded in the solder provide surgeons with immediate feedback on tissue temperatures during laser application, all while within the confines of minimally invasive (robotic) surgical setups. By integrating fluorescent nanothermometry-guided laser tissue surgery into endoscopic and robotic surgery, the study paves the way for a new approach for safe and atraumatic soft tissue joining, especially in regions where traditional suturing is unfeasible.}, archive = {J_ADVS}, author = {Oscar Cipolato and Tobias Leuthold and Marius Zäch and Georg Männel and Sam Aegerter and Calinda Sciascia and Alexander Jessernig and Marco von Salis and Sima Sarcevic and Jachym Rosendorf and Vaclav Liska and Dennis Kundrat and Romain Quidant and Inge K. Herrmann}, doi = {10.1002/advs.202406671}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2406671}, shortjournal = {Adv. Sci.}, title = {Robotic laser tissue soldering for atraumatic soft tissue fusion guided by fluorescent nanothermometry}, volume = {12}, year = {2025}, }
• (2025). A distinguished roadmap of fibroblast senescence in predicting immunotherapy response and prognosis across human cancers. ADVS, 12(7), 2406624. (www)

  @article{ , abstract = {The resistance of tumors to immune checkpoint inhibitors (ICI) may be intricately linked to cellular senescence, although definitive clinical validation remains elusive. In this study, comprehensive pan-cancer scRNA-seq analyses identify fibroblasts as exhibiting the most pronounced levels of cellular senescence among tumor-associated cell populations. To elucidate this phenomenon, a fibroblast senescence-associated transcriptomic signature (FSS), which correlated strongly with protumorigenic signaling pathways and immune dysregulation that fosters tumor progression, is developed. Leveraging the FSS, the machine learning (ML) framework demonstrates exceptional accuracy in predicting ICI response and survival outcomes, achieving superior area under curve (AUC) values across validation, testing, and in-house cohorts. Strikingly, FSS consistently outperforms established signatures in predictive robustness across diverse cancer subtypes. From an integrative analysis of 17 CRISPR/Cas9 libraries, CDC6 emerges as a pivotal biomarker for pan-cancer ICI response and prognostic stratification. Mechanistically, experimental evidence reveals that CDC6 in tumor cells orchestrates fibroblast senescence via TGF-β1 secretion and oxidative stress, subsequently reprogramming the tumor microenvironment and modulating ICI response. These findings underscore the translational potential of targeting fibroblast senescence as a novel therapeutic strategy to mitigate immune resistance and enhance antitumor efficacy.}, archive = {J_ADVS}, author = {Dongjie Chen and Pengyi Liu and Jiayu Lin and Longjun Zang and Yihao Liu and Shuyu Zhai and Xiongxiong Lu and Yuanchi Weng and Hongzhe Li}, doi = {10.1002/advs.202406624}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2406624}, shortjournal = {Adv. Sci.}, title = {A distinguished roadmap of fibroblast senescence in predicting immunotherapy response and prognosis across human cancers}, volume = {12}, year = {2025}, }
• (2025). A milk extracellular vesicle-based nanoplatform enhances combination therapy against multidrug-resistant bacterial infections. ADVS, 12(7), 2406496. (www)

  @article{ , abstract = {The increasing occurrence of infections caused by multidrug-resistant (MDR) bacteria drives the need for new antibacterial drugs. Due to the current lack of antibiotic discovery and development, new strategies to fight MDR bacteria are urgently needed. Efforts to develop new antibiotic adjuvants to increase the effectiveness of existing antibiotics and design delivery systems are essential to address this issue. Here, a bioinspired delivery system equipped with combination therapy and paracellular transport is shown to enhance the efficacy against bacterial infections by improving oral delivery. A screening platform is established using an in vitro-induced high polymyxin-resistant strain to acquire plumbagin, which enhances the efficacy of polymyxin. Functionalized milk extracellular vesicles (FMEVs) coloaded with polymyxin and plumbagin cleared 99% of the bacteria within 4 h. Mechanistic studies revealed that the drug combination damaged the membrane, disrupted energy metabolism, and accelerated bacterial death. Finally, FMEVs are efficiently transported transcellularly through the citric acid-mediated reversible opening of the tight junctions and showed high efficacy against an MDR Escherichia coli -associated peritonitis–sepsis model in mice. These findings provide a potential therapeutic strategy to improve the efficacy of combination therapy by enhancing oral delivery using a biomimetic delivery platform.}, archive = {J_ADVS}, author = {Shaoqi Qu and Shuo Yang and Qingjun Xu and Mengying Zhang and Feng Gao and Yongning Wu and Lin Li}, doi = {10.1002/advs.202406496}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2406496}, shortjournal = {Adv. Sci.}, title = {A milk extracellular vesicle-based nanoplatform enhances combination therapy against multidrug-resistant bacterial infections}, volume = {12}, year = {2025}, }
• (2025). Touch empowerment: Self-sustaining e-tattoo thermoelectric system for temperature mapping. ADVS, 12(7), 2403775. (www)

  @article{ , abstract = {In recent advancements within sensing technology, driven by the Internet of Things (IoT), significant impacts are observed on health sector applications, notably through wearable electronics like electronic tattoos (e-tattoos). These e-tattoos, designed for direct contact with the skin, facilitate precise monitoring of vital physiological parameters, including body heat, a critical indicator for conditions such as inflammation and infection. Monitoring these indicators can be crucial for early detection of chronic conditions, steering toward proactive healthcare management. This study delves into a thermoelectric sensor e-tattoo designed for detailed skin temperature mapping. Utilizing a novel design, this sensor detects temperature variations across thermoelectric stripes, leveraging screen-printed films of p-type Bi 0.35 Sb 1.65 Te 3 , n-type Bi 2 Te 2.8 Se 0.2 , and poly(vinyl alcohol) (PVA) for enhanced thermoelectric and flexible properties. The application of a prototype printed thermoelectric device on temporary tattoo paper, a pioneering development in wearable health technology is demonstrated. This device, validated through numerical simulations, exhibits significant potential as a non-invasive tool for temperature monitoring, highlighting its value in health diagnostics and management.}, archive = {J_ADVS}, author = {M. A. S. Almeida and A. L. Pires and J. L. Ramirez and S. B. Malik and S. de la Flor and E. Llobet and A. T. Pereira and A. M. Pereira}, doi = {10.1002/advs.202403775}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2403775}, shortjournal = {Adv. Sci.}, title = {Touch empowerment: Self-sustaining e-tattoo thermoelectric system for temperature mapping}, volume = {12}, year = {2025}, }
• (2025). Actuation-mediated compression of a mechanoresponsive hydrogel by soft robotics to control release of therapeutic proteins. ADVS, 12(7), 2401744. (www)

  @article{ , abstract = {Therapeutic proteins, the fastest growing class of pharmaceuticals, are subject to rapid proteolytic degradation in vivo, rendering them inactive. Sophisticated drug delivery systems that maintain protein stability, prolong therapeutic effects, and reduce administration frequency are urgently required. Herein, a mechanoresponsive hydrogel is developed contained within a soft robotic drug delivery (SRDD) device. In a step-change from previously reported systems, pneumatic actuation of this system releases the cationic therapeutic protein Vascular Endothelial Growth Factor (VEGF) in a bioactive form which is required for therapeutic angiogenesis, the growth of new blood vessels, in numerous clinical conditions. The ability of the SRDD device to release bioactive VEGF in a spatiotemporal manner from the hydrogel is tested in diabetic rats – a model in which angiogenesis is difficult to stimulate. Daily actuation of the SRDD device in the diabetic rat model significantly increased cluster of differentiation 31+ (CD31+) blood vessel number (p = 0.0335) and the diameter of alpha-smooth muscle actin+ (α-SMA+) blood vessels (p = 0.0025) compared to passive release of VEGF from non-actuated devices. The SRDD device combined with the mechanoresponsive hydrogel offers the potential to deliver an array of bioactive therapeutics in a spatiotemporal manner to mimic their natural release in vivo.}, archive = {J_ADVS}, author = {Eimear J. Wallace and Joanne O'Dwyer and Eimear B. Dolan and Liam P. Burke and Robert Wylie and Gabriella Bellavia and Stefania Straino and Francesca Cianfarani and Gabriella Ciotti and Simona Serini and Gabriella Calviello and Ellen T. Roche and Tapas Mitra and Garry P. Duffy}, doi = {10.1002/advs.202401744}, journal = {Advanced Science}, month = {2}, number = {7}, pages = {2401744}, shortjournal = {Adv. Sci.}, title = {Actuation-mediated compression of a mechanoresponsive hydrogel by soft robotics to control release of therapeutic proteins}, volume = {12}, year = {2025}, }
• (2025). Hybrid cell membrane-engineered nanocarrier for triple-action strategy to address pseudomonas aeruginosa infection (Adv. sci. 6/2025). ADVS, 12(6), 2570036. (www)

  @article{ , archive = {J_ADVS}, author = {Shunhao Zhang and Tianyu Chen and Weitong Lu and Yunfeng Lin and Mi Zhou and Xiaoxiao Cai}, doi = {10.1002/advs.202570036}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2570036}, shortjournal = {Adv. Sci.}, title = {Hybrid cell membrane-engineered nanocarrier for triple-action strategy to address pseudomonas aeruginosa infection (Adv. sci. 6/2025)}, volume = {12}, year = {2025}, }
• (2025). Capture of totipotency in mouse embryonic stem cells in the absence of pdzk1 (Adv. sci. 6/2025). ADVS, 12(6), 2570035. (www)

  @article{ , archive = {J_ADVS}, author = {Wenhao Zhang and Yiding Zhao and Zhe Yang and Jing Yan and Haisong Wang and Shaochen Nie and Qingshen Jia and Dan Ding and Chao Tong and Xiao-Ou Zhang and Qian Gao and Ling Shuai}, doi = {10.1002/advs.202570035}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2570035}, shortjournal = {Adv. Sci.}, title = {Capture of totipotency in mouse embryonic stem cells in the absence of pdzk1 (Adv. sci. 6/2025)}, volume = {12}, year = {2025}, }
• (2025). Ternary logic transistors using multi-stacked 2D electron gas channels in ultrathin oxide heterostructures (Adv. sci. 6/2025). ADVS, 12(6), 2570033. (www)

  @article{ , archive = {J_ADVS}, author = {Ji Hyeon Choi and Tae Jun Seok and Sang June Kim and Kyun Seong Dae and Jae Hyuck Jang and Deok-Yong Cho and Sang Woon Lee and Tae Joo Park}, doi = {10.1002/advs.202570033}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2570033}, shortjournal = {Adv. Sci.}, title = {Ternary logic transistors using multi-stacked 2D electron gas channels in ultrathin oxide heterostructures (Adv. sci. 6/2025)}, volume = {12}, year = {2025}, }
• (2025). A novel “Three-in-one” copper-based metal-organic framework nanozyme eradicates colorectal cancer and overcomes chemoresistance for tumor therapy (Adv. sci. 6/2025). ADVS, 12(6), 2570032. (www)

  @article{ , archive = {J_ADVS}, author = {Shuohui Dong and Haolin Cao and Ye Yuan and Shuo Liang and Zhendong Fu and Wei Shi and Qian Xu and Xiang Zhao and Jingnan Shi and Xiaoxiao Guo and Kaili Guo and Sanyuan Hu and Guangyong Zhang and Lizeng Gao and Lei Chen}, doi = {10.1002/advs.202570032}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2570032}, shortjournal = {Adv. Sci.}, title = {A novel “Three-in-one” copper-based metal-organic framework nanozyme eradicates colorectal cancer and overcomes chemoresistance for tumor therapy (Adv. sci. 6/2025)}, volume = {12}, year = {2025}, }
• (2025). Engineered mesenchymal stem cell-derived extracellular vesicles scavenge self-antigens for psoriasis therapy via modulating metabolic and immunological disorders (Adv. sci. 6/2025). ADVS, 12(6), 2570031. (www)

  @article{ , archive = {J_ADVS}, author = {Xin Zhou and Bo Tang and Qing Huang and Siyu Yang and Yang Jiang and Lizhou Xu and Wen Chen and Guangchang Shan and Xuankai Liao and Chongchao Hou and Zhihong Yao and Chaowei Zou and Rongying Ou and Yunsheng Xu and Danyang Li}, doi = {10.1002/advs.202570031}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2570031}, shortjournal = {Adv. Sci.}, title = {Engineered mesenchymal stem cell-derived extracellular vesicles scavenge self-antigens for psoriasis therapy via modulating metabolic and immunological disorders (Adv. sci. 6/2025)}, volume = {12}, year = {2025}, }
• (2025). Suppression of hepatocyte ferroptosis via USP19-mediated deubiquitination of SLC7A11 in ischemia-free liver transplantation (Adv. sci. 6/2025). ADVS, 12(6), 2570030. (www)

  @article{ , archive = {J_ADVS}, author = {Jinghong Xu and Shirui Chen and Di Liu and Qi Zhang and Tao Luo and Jiaxing Zhu and Liang Zhou and Yuan Lin and Hongyu Pan and Yichao Chen and Qiang Zhao and Tielong Wang and Schlegel Andrea and Björn Nashan and Tullius G. Stefan and Changjie Cai and Jun Cui and Xiaoshun He and Zhiyong Guo}, doi = {10.1002/advs.202570030}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2570030}, shortjournal = {Adv. Sci.}, title = {Suppression of hepatocyte ferroptosis via USP19-mediated deubiquitination of SLC7A11 in ischemia-free liver transplantation (Adv. sci. 6/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “Small extracellular vesicle-derived vWF induces a positive feedback loop between tumor and endothelial cells to promote angiogenesis and metastasis in hepatocellular carcinoma”. ADVS, 12(6), 2416993. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202416993}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2416993}, shortjournal = {Adv. Sci.}, title = {Correction to “Small extracellular vesicle-derived vWF induces a positive feedback loop between tumor and endothelial cells to promote angiogenesis and metastasis in hepatocellular carcinoma”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Light-activated anti-vascular combination therapy against choroidal neovascularization”. ADVS, 12(6), 2416443. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202416443}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2416443}, shortjournal = {Adv. Sci.}, title = {Correction to “Light-activated anti-vascular combination therapy against choroidal neovascularization”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Red light-triggered anti-angiogenic and photodynamic combination therapy of age-related macular degeneration”. ADVS, 12(6), 2416442. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202416442}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2416442}, shortjournal = {Adv. Sci.}, title = {Correction to “Red light-triggered anti-angiogenic and photodynamic combination therapy of age-related macular degeneration”}, volume = {12}, year = {2025}, }
• (2025). High-spin states of Manganese(III) enable robust cold-adapted activity of MnO2 nanozymes. ADVS, 12(6), 2415477. (www)

  @article{ , abstract = {Developing novel cold-adapted nanozymes and elucidating their mechanisms of action remains a great challenge. Inspired by natural oxidases that utilize high-spin and high-valent metal-oxygen intermediates to achieve high efficiency at low temperatures, in this study, a series of MnO x nanomaterials with varied valence and spin states are synthesized. The activity assay revealed that the oxygen vacancy-engineered ε -MnO 2 nanozyme displayed excellent cold-adapted oxidase-like properties, and no observable activity loss is observed in the temperature range of −20 to 45 °C. The superior performance is attributed to the high-spin Mn(III)–O species coupled with its induced Jahn–Teller effect, which facilitates the dissociation and activation of oxygen at low temperatures. As a proof of concept, an excellent cold-adapted δ -MnO 2 nanozyme can be obtained using Mn 3 O 4 as the precursor by regulating the spin state of Mn(III). Moreover, a novel and effective degradation strategy for corn stalk at low temperature is built based on the robust cold-adapted oxidase-like activity of ε -MnO 2 . These results not only provide new insights for the rational design of cold-adapted nanozymes but also broaden the application of nanozymes in low-temperature industrial processes.}, archive = {J_ADVS}, author = {Qing Tian and Shuaiqi Huangfu and Ge Kang and Haoyu Wang and Huile Liu and Xuejing Wang and Aipeng Li and Yao Chen and Kelong Fan and Lianbing Zhang}, doi = {10.1002/advs.202415477}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2415477}, shortjournal = {Adv. Sci.}, title = {High-spin states of Manganese(III) enable robust cold-adapted activity of MnO2 nanozymes}, volume = {12}, year = {2025}, }
• (2025). Targeting piRNA-137463 inhibits tumor progression and boosts sensitivity to immune checkpoint blockade via de novo cholesterol biosynthesis in lung adenocarcinoma. ADVS, 12(6), 2414100. (www)

  @article{ , abstract = {The important role of PIWI-interacting RNAs (piRNAs) in tumors has garnered increasing attention. However, research on their role in lung adenocarcinoma (LUAD) remains limited. Elevated levels of piRNA-137463 have been linked to poor prognosis in LUAD patients. Inhibition of piRNA-137463 curbed the proliferation, migration, and invasion of LUAD cells, enhanced T cell cytotoxicity through increased IFN-γ secretion, disrupted cholesterol metabolism, and reduced intracellular cholesterol, lipid raft content, and PD-L1 expression in LUAD cells. Bioinformatic prediction identified a potential interaction between piRNA-137463 and lncRNA LOC100128494. Inhibiting piRNA-137463 increased the stability and expression of LOC100128494, which further modulated insulin-induced gene 1 protein (INSIG1) levels via a competitive endogenous RNA network involving LOC100128494 and miR-24-3p. Notably, the effect of piRNA-137463 in LUAD cells is dependent on the expression of LOC100128494 and INSIG1. Inhibiting the expression of piRNA-137463 with AntagopiRNA-137463 suppressed tumor growth and metastasis via LOC100128494 in nude mice and enhanced the response of LUAD to anti-PD-1 therapy in immune-competent mice. In summary, this study elucidates the role of piRNA-137463 in the reprogramming of cholesterol metabolism, which drives the progression of LUAD, thereby identifying a new target for the comprehensive clinical management of LUAD.}, archive = {J_ADVS}, author = {Yuning Zhan and Fanglin Tian and Weina Fan and Xin Li and Xiangyu Wang and Hongxia Zhang and Xin Hong and Xin Wang and Li Cai and Yang Song and Ying Xing}, doi = {10.1002/advs.202414100}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2414100}, shortjournal = {Adv. Sci.}, title = {Targeting piRNA-137463 inhibits tumor progression and boosts sensitivity to immune checkpoint blockade via de novo cholesterol biosynthesis in lung adenocarcinoma}, volume = {12}, year = {2025}, }
• (2025). DRD4 interacts with TGF-β receptors to drive colorectal cancer metastasis independently of dopamine signaling pathway. ADVS, 12(6), 2413953. (www)

  @article{ , abstract = {The functional and pharmacological significance of dopamine receptor D4 (DRD4) in psychiatric and neurological disorders is well elucidated. However, the roles of DRD4 in colorectal cancer (CRC) remain unclear. This study observes a significant upregulation of DRD4 expression in clinical samples, which is negatively correlated with patient prognosis. In vitro, overexpression of DRD4 causes a constitutive activation of β-Arrestin2/PP2A/AKT independent of dopamine. Interestingly, this classical signaling pathway is not associated with the phenotype of DRD4-promoted migration and invasion in CRC cells. Instead, DRD4 interacts with transforming growth factor beta receptors (TGFBR1 and TGFBR2) to activate Smad2 phosphorylation and promote Smad2/Smad4 complex nucleus translocation. Then, SNAI1 and JAG1 are transcriptionally activated to induce epithelial-mesenchymal transition and enhance the metastatic potential of CRC. Notably, the COOH-terminal domain is identified as the key intracellular region for the pro-metastatic roles of DRD4. Furthermore, treatment with a TGFBR1 inhibitor combined with a BMP inhibitor effectively counteracts the pro-metastatic effects induced by DRD4 both in vitro and in vivo. In conclusion, these findings uncover an unconventional role for DRD4 beyond its classic function as a neurotransmitter receptor. The intracellular signaling of DRD4 interacting with TGFBR1 can be targeted pharmacologically for CRC therapy.}, archive = {J_ADVS}, author = {Yuan Zhou and Jinlong Tang and Menghan Weng and Honghe Zhang and Maode Lai}, doi = {10.1002/advs.202413953}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2413953}, shortjournal = {Adv. Sci.}, title = {DRD4 interacts with TGF-β receptors to drive colorectal cancer metastasis independently of dopamine signaling pathway}, volume = {12}, year = {2025}, }
• (2025). Fully printable manufacturing of miniaturized, highly integrated, flexible evaporation-driven electricity generator arrays. ADVS, 12(6), 2413779. (www)

  @article{ , abstract = {Harvesting sustainable clean energy from natural water evaporation holds great promise to provide continuous power for portable and wearable electronics. However, poor portability and complex fabrication processes hinder the low-cost and large-scale integration of flexible evaporation-driven electricity generators (FEEGs). Herein, a fully-printed flexible evaporation-driven generator (PFEEG) is developed. Utilizing custom-formulated functional inks, the asymmetric structures, current collectors, and hygroscopic water storage units can be manufactured by a patternable, scalable, and layer-by-layer deposition technique of screen printing. Thus, a PFEEG unit (0.5 cm × 1 cm × 38 µm) can generate a voltage of ≈0.8 V over a wide relative humidity (RH) range from 20% to 90%, and a maximum power density of 1.55 µW cm −2 at 70% RH. An array of 200 PFEEGs connected in series or parallel can produce voltages up to 152.41 V or a current up to 1.02 mA. Furthermore, the scalable PFEEG array can not only be seamlessly connected with the printed flexible circuit but can also be integrated with a humidity sensor and display arrays to form a self-powered printed flexible sensing system. This work presents a practical strategy for continuous power supply of portable and wearable electronics.}, archive = {J_ADVS}, author = {Qun Liu and Panwang Guo and Xinyu Zhang and Hehe Ren and Jing Liang and Quancai Li and Weinan Tang and Wei Wu}, doi = {10.1002/advs.202413779}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2413779}, shortjournal = {Adv. Sci.}, title = {Fully printable manufacturing of miniaturized, highly integrated, flexible evaporation-driven electricity generator arrays}, volume = {12}, year = {2025}, }
• (2025). RUNX2 phase separation mediates long-range regulation between osteoporosis-susceptibility variant and XCR1 to promote osteoblast differentiation. ADVS, 12(6), 2413561. (www)

  @article{ , abstract = {GWASs have identified many loci associated with osteoporosis, but the underlying genetic regulatory mechanisms and the potential drug target need to be explored. Here, a new regulatory mechanism is found that a GWAS intergenic SNP (rs4683184) functions as an enhancer to influence the binding affinity of transcription factor RUNX2, whose phase separation can mediate the long-range chromatin interaction between enhancer and target gene XCR1 (a member of the GPCR family), leading to changes of XCR1 expression and osteoblast differentiation. Bone-targeting AAV of Xcr1 can improve bone formation in osteoporosis mice, suggesting that XCR1 can be a new susceptibility gene for osteoporosis. This study is the first to link non-coding SNP with phase separation, providing a new insight into long-range chromatin regulation mechanisms with susceptibility to complex diseases, and finding a potential target for the development of osteoporosis drugs and corresponding translational research.}, archive = {J_ADVS}, author = {Yan Zhang and Xin-Hao Li and Pai Peng and Zi-Han Qiu and Chen-Xi Di and Xiao-Feng Chen and Nai-Ning Wang and Fei Chen and Yin-Wei He and Zhong-Bo Liu and Fan Zhao and Dong-Li Zhu and Shan-Shan Dong and Shou-Ye Hu and Zhi Yang and Yi-Ping Li and Yan Guo and Tie-Lin Yang}, doi = {10.1002/advs.202413561}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2413561}, shortjournal = {Adv. Sci.}, title = {RUNX2 phase separation mediates long-range regulation between osteoporosis-susceptibility variant and XCR1 to promote osteoblast differentiation}, volume = {12}, year = {2025}, }
• (2025). Ambient synthesis of cyclohexanone oxime via in situ produced hydrogen peroxide over cobalt-based electrocatalyst. ADVS, 12(6), 2413475. (www)

  @article{ , abstract = {Cyclohexanone oxime, a critical precursor for nylon-6 production, is traditionally synthesized via the hydroxylamine method under industrial harsh conditions. Here is present a one-step electrochemical integrated approach for the efficient production of cyclohexanone oxime under ambient conditions. This approach employed the coupling of in situ electro-synthesized H 2 O 2 over a cobalt (Co)-based electrocatalyst with the titanium silicate-1 (TS-1) heterogeneous catalyst to achieve the cyclohexanone ammoximation process. The cathode electrocatalyst is consisted of atomically dispersed Co sites and small Co nanoparticles co-anchored on carboxylic multi-walled carbon nanotubes (CoSAs/SNPs-OCNTs), which delivered superior electrocatalytic activity toward the two-electron oxygen reduction reaction (2e − ORR) with high-efficient H 2 O 2 production in 0.1 m sodium phosphate (NaPi). Theoretical calculations revealed that the introduction of Co nanoparticles effectively optimized the binding strength of * OOH species on Co atomic sites, thus facilitating the 2e − ORR. The subsequent tandem catalytic system achieved a high cyclohexanone conversion of 71.7% ± 1.1% with a cyclohexanone oxime selectivity of 70.3% ± 0.6%. In this system, the TS-1 catalyst effectively captured the * OOH intermediate and activated the in situ generated H 2 O 2 to form Ti-OOH species, which promoted the formation of hydroxylamine and thereby enhanced the oxime production performance.}, archive = {J_ADVS}, author = {Hui Xu and Meng Jin and Shengbo Zhang and Xinyuan Zhang and Min Xu and Yunxia Zhang and Guozhong Wang and Haimin Zhang}, doi = {10.1002/advs.202413475}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2413475}, shortjournal = {Adv. Sci.}, title = {Ambient synthesis of cyclohexanone oxime via in situ produced hydrogen peroxide over cobalt-based electrocatalyst}, volume = {12}, year = {2025}, }
• (2025). A novel “Three-in-one” copper-based metal-organic framework nanozyme eradicates colorectal cancer and overcomes chemoresistance for tumor therapy. ADVS, 12(6), 2413422. (www)

  @article{ , abstract = {Despite considerable advancements in the treatment of colorectal cancer (CRC), the overall survival rate for patients with advanced CRC remains below 50%, primarily due to challenges posed by drug resistance and metastasis. Here, a novel “Three-in-One” Cu-based metal-organic framework nanozyme with peroxidase-like (POD-like) activity has been successfully developed, aiming to promote CRC cell death by dual targeting of oxidative stress and copper ion homeostasis, which could promote CRC cell death via apoptosis and cuproptosis, and facilitate hypoxia-inducible factor 1α (HIF-1α) degradation, leading to the reversal of chemoresistance in tumor therapy. These nanozymes, composed of copper and 2-propylimidazole (Cu-PrIm), feature a distorted Cu-N4 catalytic active center that mimics natural enzyme structures consisting of copper and histidine residues, endowing them with enzyme-like activities. The antitumor efficacy of Cu-PrIm nanozymes is validated in various in vivo models of CRC. Especially Cu-PrIm nanozymes exhibit excellent biocompatibility, biodegradability, and a tolerable toxicity profile in mouse models, making them a strong candidate for clinical translation. Taken together, the study introduces a novel therapeutic paradigm in CRC treatment by targeting these vulnerabilities and leveraging the potential using “Three-in-One” Cu-PrIm nanozymes to address multiple pathways simultaneously.}, archive = {J_ADVS}, author = {Shuohui Dong and Haolin Cao and Ye Yuan and Shuo Liang and Zhendong Fu and Wei Shi and Qian Xu and Xiang Zhao and Jingnan Shi and Xiaoxiao Guo and Kaili Guo and Sanyuan Hu and Guangyong Zhang and Lizeng Gao and Lei Chen}, doi = {10.1002/advs.202413422}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2413422}, shortjournal = {Adv. Sci.}, title = {A novel “Three-in-one” copper-based metal-organic framework nanozyme eradicates colorectal cancer and overcomes chemoresistance for tumor therapy}, volume = {12}, year = {2025}, }
• (2025). Engineering dual active sites and defect structure in nanozymes to reprogram jawbone microenvironment for osteoradionecrosis therapy. ADVS, 12(6), 2413215. (www)

  @article{ , abstract = {Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis of the jaw (ORNJ) after radiotherapy. Various radiation-induced tissue injuries are associated with reactive oxygen and nitrogen species (RONS) overproduction. Herein, Fe doping is used in VO x (Fe-VO x ) nanozymes with multienzyme activities for ORNJ treatment via RONS scavenging. Fe doping can induce structure reconstruction of nanozymes with abundant defect production, including Fe substitution and oxygen vacancies (OVs), which markedly increased multiple enzyme-mimicking activity. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzyme-like performance of Fe-VO x can effectively reprogram jawbone microenvironment to restore mitochondrial dysfunction and enhance mitophagy. Moreover, the surface plasmon resonance (SPR) effect of Fe-VO x made it a good photothermal nanoagents for inhibiting jaw infection. Thus, this work demonstrated that Fe-VO x nanozymes can efficiently scavenge RONS, activate mitophagy, and inhibit bacteria, which is potential for ORNJ treatment.}, archive = {J_ADVS}, author = {Zheng Cheng and Yuchen Wang and Haobo Lin and Ziyu Chen and Ran Qin and Tianxiao Wang and Hang Xu and Yifei Du and Hua Yuan and Yongchu Pan and Huijun Jiang and Xinquan Jiang and Jiandong Jiang and Fan Wu and Yuli Wang}, doi = {10.1002/advs.202413215}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2413215}, shortjournal = {Adv. Sci.}, title = {Engineering dual active sites and defect structure in nanozymes to reprogram jawbone microenvironment for osteoradionecrosis therapy}, volume = {12}, year = {2025}, }
• (2025). Ionic thermoelectric-powered resistive sensors. ADVS, 12(6), 2413093. (www)

  @article{ , abstract = {Ionic thermoelectric supercapacitors (ITESCs) are noted for their high ionic Seebeck coefficient (α) to convert thermal energy into electrical current through charging. This work demonstrates the utilization of the charging and discharging current from ITESCs to directly operate resistive sensors. The humidity monitoring is powered by applying a periodic temperature gradient to a connected ITESC. By leveraging these properties and residual environmental heat, ITESCs can offer a promising method for autonomously powered portable sensors.}, archive = {J_ADVS}, author = {Mingna Liao and Hongting Ma and Nan Zhu and Magnus P. Jonsson and Dan Zhao}, doi = {10.1002/advs.202413093}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2413093}, shortjournal = {Adv. Sci.}, title = {Ionic thermoelectric-powered resistive sensors}, volume = {12}, year = {2025}, }
• (2025). Flexible X-ray detector for cumulative dose monitoring through reversible photochromism and luminescence modulation. ADVS, 12(6), 2412986. (www)

  @article{ , abstract = {This study presents a multi-mode X-ray detection and imaging strategy by integrating photochromism, photoluminescence, and radioluminescence into Tb 3+ -doped CaAl 2 Si 2 O 8 . CaAl 2 Si 2 O 8 : Tb 3+ exhibits stable radioluminescence, oxygen vacancy-related photochromism, and photoluminescence modulation, all of which showed a linear relationship with X-ray exposure. This multi-mode response enables high-quality imaging and detection in both bright and dark conditions, facilitating time-dependent cumulative X-ray radiation dose assessments. Reversible color and luminescence changes are achieved through cyclic tests involving alternating X-ray and 473 nm laser irradiation. The PDMS CaAl 2 Si 2 O 8 : Tb 3+ ink and flexible film demonstrate high suitability for wearable X-ray detection devices and imaging of irregular objects, offering an innovative approach to X-ray detection and imaging.}, archive = {J_ADVS}, author = {Xue Bai and Yueteng Zhang and Heping Zhao and Yingzhu Zi and Zan Xu and Anjun Huang and Yangke Cun and Yue Liu and Zhiguo Song and Jianbei Qiu and Jiayan Liao and Zhengwen Yang}, doi = {10.1002/advs.202412986}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412986}, shortjournal = {Adv. Sci.}, title = {Flexible X-ray detector for cumulative dose monitoring through reversible photochromism and luminescence modulation}, volume = {12}, year = {2025}, }
• (2025). Organohydrogel based electronic skin reinforced by dual-mode conduction and hierarchical collagen fibers skeleton. ADVS, 12(6), 2412934. (www)

  @article{ , abstract = {Collagen fiber skeleton from animal skin is an ideal substrate for electronic skin (e-skin). However, the interface mismatch between conductive materials and skeleton and the monotonicity of conductive network still hinder its creation. Herein, a novel collagen fiber-based e-skin with dual-mode conduction of NaCl and conductive spheres (IECS) is accomplished by loading organohydrogel into the skeleton via “permeation and self-assembly”. The resulting interpenetrating network produces a 3D continuous, conductive pathway and strong interface interaction with high-density hydrogen bonding, thus exhibiting excellent strength (24.5 MPa), conductivity (14.82 S m −1 ), sensing performance (sensitivity of 16.64), and environmental stability. The physical structure (3D skeleton, interpenetrating network) and chemical interaction (interface interaction, salting-out) achieve energy dissipation. Meanwhile, the sensitivity is enhanced by dual-mode conduction, conductive sphere array, and deformation amplification induced by collagen fibers. Additionally, the strong bonding ability between glycerin and collagen fibers with water molecules provides anti-freezing and moisture-retention characteristics. Thus, the strategic synergy of compositional and structural design makes IECS a promising force-sensing part of piezoresistive sensor for human movement, pulse frequency, cipher transmission, and pressure distribution. In short, IECS presents a multifunctional platform for the invention of high-performance e-skin with on-demand property, which offers great application potential in wearable electronics.}, archive = {J_ADVS}, author = {Ruyue Guo and Yan Bao and Xi Zheng and Jie Chen and Wenbo Zhang and Chao Liu and Jianzhong Ma}, doi = {10.1002/advs.202412934}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412934}, shortjournal = {Adv. Sci.}, title = {Organohydrogel based electronic skin reinforced by dual-mode conduction and hierarchical collagen fibers skeleton}, volume = {12}, year = {2025}, }
• (2025). Carbon nanocage-in-microcage structure with tunable carbon-coated nickel as a microwave absorber with infrared stealth property. ADVS, 12(6), 2412890. (www)

  @article{ , abstract = {The rational design of microwave absorption (MA) material featuring light weight, wide absorption bandwidth, and infrared stealth property is crucial for military stealth and health protection but remains challenging. Herein, an innovative N-doped carbon nanocage-in-microcage structure with tunable carbon-coated Ni (NC/Ni(HS)) is reported via a reliable Ni-catalyzed and Ni-templated method. The hierarchically hollow structure of nanocage-in-microcage composites can optimize the impedance matching and respond to multiple reflections and scattering of incident microwaves and infrared waves. Moreover, the magnetic Ni nanoparticles improve the synergistic interactions between confined heterointerfaces and promote interfacial polarization. Such an ingenious structure endows NC/Ni(HS) with outstanding MA performance and infrared stealth properties. Specifically, NC/Ni(HS)-10 with an optimal dielectric property, exhibits excellent MA performance. At an ultralow fill loading of 4 wt.%, a wide absorption bandwidth of 6.16 GHz is achieved at a thickness of 2.63 mm, and a strong reflection loss of −63.67 dB is obtained at a thickness of 2.00 mm. In addition, NC/Ni(HS)-10 shows a low infrared emissivity in the range of 3‒14 µm, which is the key to compatibility with infrared stealth. This work paves the way for the design of advanced MA materials that meet the requirements of multispectral-compatible stealth.}, archive = {J_ADVS}, author = {Zhaoyang Li and Yang Xu and Lihong Wu and Yu Sun and Mingnan Zhang and Zhifeng Dou and Jinchuan Zhao and Yongzhu Yan and Guizhen Wang}, doi = {10.1002/advs.202412890}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412890}, shortjournal = {Adv. Sci.}, title = {Carbon nanocage-in-microcage structure with tunable carbon-coated nickel as a microwave absorber with infrared stealth property}, volume = {12}, year = {2025}, }
• (2025). Bifunctional design of ferroelectric-order and band-engineering in cu: KTN crystal for extended self-powered photoelectric response. ADVS, 12(6), 2412877. (www)

  @article{ , abstract = {Photoelectric conversion in ferroelectric crystals can support many important applications in modern on-chip technology, but suffering from two problems, low responsive current and narrow responsive range. Especially, wide-gap ferroelectric oxides are only active at short-wavelength ultraviolet region with weak photocurrent at nanoampere levels. Here, a bifunctional design strategy of ferroelectric-order and electronic-band to improve the photocurrent and extend the responsive range simultaneously, is proposed. In a Cu-doped KTa 1− x Nb x O 3 (KTN) perovskite crystal, a conductive channel is constructed by “head-to-head” ferroelectric domains, associated with the emergence of micrometer-scale supercells. In addition, the introduction of Cu + ion can induce defect levels, thus extending the responsive range beyond the inherent absorption of pure KTN. Through rational device optimization, a record self-powered responsivity of 5.23 mA W −1 is realized in Cu:KTN photodetector, which is two orders of magnitude higher than undoped KTN crystal. The temperature-dependent light diffraction and photocurrent show that the ferroelectric-order is dominated in this photoresponse behavior. Moreover, Cu:KTN detector is active in the broadband range from 390 to 1030 nm, covering ultraviolet, visible, and near-infrared regions. This work provides an effective method for the design of next-generation self-powered photodetectors with ultrahigh responsivity and ultrawide responsive range.}, archive = {J_ADVS}, author = {Yaqian Wang and Yabo Wu and Fei Liang and Xuping Wang and Haohai Yu and Huaijin Zhang and Yicheng Wu}, doi = {10.1002/advs.202412877}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412877}, shortjournal = {Adv. Sci.}, title = {Bifunctional design of ferroelectric-order and band-engineering in cu: KTN crystal for extended self-powered photoelectric response}, volume = {12}, year = {2025}, }
• (2025). Optimizing interfacial charge dynamics and quantum effects in heterodimensional superlattices for efficient hydrogen production. ADVS, 12(6), 2412805. (www)

  @article{ , abstract = {Superlattice materials have emerged as promising candidates for water electrocatalysis due to their tunable crystal structures, electronic properties, and potential for interface engineering. However, the catalytic activity of transition metal-based superlattice materials for the hydrogen evolution reaction (HER) is often constrained by their intrinsic electronic band structures, which can limit charge carrier mobility and active site availability. Herein, a highly efficient electrocatalyst based on a VS 2 -VS heterodimensional (2D-1D) superlattice with sulfur vacancies is designed addressing the limitations posed by the intrinsic electronic structure. The enhanced catalytic performance of the VS 2 -VS superlattice is primarily attributed to the engineered heterojunction, where the work function difference between the VS 2 layer and VS chain induces a charge separation field that promotes efficient electron-hole separation. Introducing sulfur vacancies further amplifies this effect by inducing quantum localization of the separated electrons, thereby significantly boosting HER activity. Both theoretical and experimental results demonstrate that the superlattice achieves a ΔG H* of −0.06 eV and an impressively low overpotential of 46 mV at 10 mA·cm −2 in acidic media, surpassing the performance of commercial Pt/C while maintaining exceptional stability over 15 000 cycles. This work underscores the pivotal role of advanced material engineering in designing catalysts for sustainable energy applications.}, archive = {J_ADVS}, author = {Jinpeng Li and Weikang Dong and Zibo Zhu and Yang Yang and Jiadong Zhou and Sufan Wang and Yao Zhou and Erhong Song and Jianjun Liu}, doi = {10.1002/advs.202412805}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412805}, shortjournal = {Adv. Sci.}, title = {Optimizing interfacial charge dynamics and quantum effects in heterodimensional superlattices for efficient hydrogen production}, volume = {12}, year = {2025}, }
• (2025). Fish fin-derived non-invasive flexible bioinspired contact lens for continuous ophthalmic drug delivery. ADVS, 12(6), 2412630. (www)

  @article{ , abstract = {Efficient drug delivery is crucial for glaucoma patients. Flexible biomedical devices that enable sustained ocular drug delivery and can regulate the drug release rate according to physiological conditions are highly desirable for glaucoma treatments, addressing both low drug bioavailability and poor patient compliance from manual drug administration, and improving treatment outcomes. Inspired by the structure and reciprocating motion of fish dorsal fins, a drug-eluting contact lens based on deformable microstructures for non-invasive ocular surface drug delivery is developed. Liquid drugs are stored within the interstices of the deformable microstructural units, allowing for continuous drug release through diffusion upon contact with the ocular surface. Finite element analysis is utilized to study the intraocular drug transport dynamics of glaucoma and optimize the overall layout of the device. Microstructural units undergo deformation under loading, altering the interstitial spaces and modulating the drug release rate. This device can adaptively adjust its drug release rate based on changes in intraocular pressure (IOP) and can be proactively regulated in response to cyclic eye loads, accommodating elevated IOP caused by varying body postures and activities. As a flexible, non-invasive, highly dynamic, and adaptive drug delivery platform, it holds significant potential for future biomedical applications.}, archive = {J_ADVS}, author = {Xu Li and Hui Li and Zihao Wang and Xianda Wang and Jinlong Zhang and Fengjiao Bin and Wei Chen and Hongyang Li and Dongmei Huo and Dengbao Xiao}, doi = {10.1002/advs.202412630}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412630}, shortjournal = {Adv. Sci.}, title = {Fish fin-derived non-invasive flexible bioinspired contact lens for continuous ophthalmic drug delivery}, volume = {12}, year = {2025}, }
• (2025). Susceptibility of mitophagy-deficient tumors to ferroptosis induction by relieving the suppression of lipid peroxidation. ADVS, 12(6), 2412593. (www)

  @article{ , abstract = {The identification of ferroptosis-sensitive cancers is critical for the application of ferroptosis-inducing therapies in cancer therapy. Here, patient-derived organoid screening models of colorectal cancer are established to identify tumors that are sensitive to ferroptosis-inducing therapy. This study discovers that patient-derived tumors characterized by mitophagy deficiency are hypersensitive to ferroptosis-inducing therapies. Mechanistically, a novel negative feedback regulatory pathway of lipid peroxidation is identified, which is one of the important intrinsic anti-ferroptosis mechanisms of cancer cells. Lipid peroxidation-mediated endoplasmic reticulum stress transcriptionally upregulates Parkin to promote mitophagy through ATF4. Mitophagy limits the generation of lipid peroxidation products and subsequently inhibits ferroptosis by inhibiting the accumulation of mitochondrial ROS. Mitophagy-deficient tumors lack this anti-ferroptotic mechanism, unleashing the generation of lipid peroxidation and potent ferroptotic cell death induced by erastin, RSL3, cysteine deprivation, radiotherapy, and immunotherapy. More importantly, ferroptosis-inducing therapy selectively inhibits the growth and distant metastasis of mitophagy-deficient tumors in vivo. In summary, patient-derived organoids of colorectal cancer patients for screening ferroptosis-sensitive tumors are established, providing a paradigm for identifying that patient-derived tumors are sensitive to ferroptosis-inducing therapies. This study concludes that mitophagy-deficient tumors are vulnerable to ferroptosis induction, which may lead to the development of new therapeutic strategies for tumors deficient in mitophagy.}, archive = {J_ADVS}, author = {Shan Liu and Jing-Hong Chen and Li-Chao Li and Zhi-Peng Ye and Jian-Nan Liu and Yu-Hong Chen and Bing-Xin Hu and Jia-Hong Tang and Gong-Kan Feng and Zhi-Ming Li and Chu-Xia Deng and Rong Deng and Xiao-Feng Zhu and Hai-Liang Zhang}, doi = {10.1002/advs.202412593}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412593}, shortjournal = {Adv. Sci.}, title = {Susceptibility of mitophagy-deficient tumors to ferroptosis induction by relieving the suppression of lipid peroxidation}, volume = {12}, year = {2025}, }
• (2025). Suppressed protein translation caused by MSP-8 deficiency determines fungal multidrug resistance with fitness cost. ADVS, 12(6), 2412514. (www)

  @article{ , abstract = {Antifungal resistance, particularly the rise of multidrug-resistance strains, poses a significant public health threat. In this study, the study identifies a novel multidrug-resistance gene, msp-8 , encoding a helicase, through experimental evolution with Neurospora crassa as a model. Deletion of msp-8 conferred multidrug resistance in N. crassa , Aspergillus fumigatus , and Fusarium verticillioides . However, the transcript levels of genes encoding known drug targets or efflux pumps remain unaltered with msp-8 deletion. Interestingly, MSP-8 interacted with ribosomal proteins, and this mutant displays compromised ribosomal function, causing translational disturbance. Notably, inhibition of protein translation enhances resistance to azoles, amphotericin B, and polyoxin B. Furthermore, MSP-8 deficiency or inhibition of translation reduces intracellular ketoconazole accumulation and membrane-bound amphotericin B content, directly causing antifungal resistance. Additionaly, MSP-8 deficiency induces cell wall remodeling, and decreases intracellular ROS levels, further contributing to resistance. The findings reveal a novel multidrug resistance mechanism independent of changes in drug target or efflux pump, while MSP-8 deficiency suppresses protein translation, thereby facilitating the development of resistance with fitness cost. This study provides the first evidence that MSP-8 participates in protein translation and that translation suppression can cause multidrug resistance in fungi, offering new insights into resistance mechanisms in clinical and environmental fungal strains.}, archive = {J_ADVS}, author = {Mi Zhou and Pengju Yu and Chengcheng Hu and Wenxia Fang and Cheng Jin and Shaojie Li and Xianyun Sun}, doi = {10.1002/advs.202412514}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412514}, shortjournal = {Adv. Sci.}, title = {Suppressed protein translation caused by MSP-8 deficiency determines fungal multidrug resistance with fitness cost}, volume = {12}, year = {2025}, }
• (2025). Enhancing field-like efficiency via interface engineering with sub-atomic layer ta insertion. ADVS, 12(6), 2412409. (www)

  @article{ , abstract = {The prevailing research emphasis has been on reducing the critical switching current density ( J c ) by enhancing the damping-like efficiency ( β DL ). However, recent studies have shown that the field-like efficiency ( β FL ) can also play a major role in reducing J c . In this study, the central inversion asymmetry of Pt-Co is significantly enhanced through interface engineering at the sub-atomic layer of Ta, thereby inducing substantial alterations in the β FL associated with the interface. The β FL has shown a 123% increase, from −1.66 Oe/(MA cm − 2 ) to -3.8 Oe/(MA cm − 2 ). As a result, the multilayered Ta/Pt/Ta (0.3 nm insertion)/Co/Ta structure leads to a notable decrease in J c , exceeding a remarkable 90% compared to the simpler Ta/Pt/Co/Ta structure, ultimately achieving a significantly low value of 2.7 MA cm − 2 . These findings pave the way for the development of highly efficient and energy-saving spin-orbit torque (SOT)-based spintronic devices, where further optimizations in interface engineering can unlock even greater potential in terms of reduced power consumption and enhanced performance.}, archive = {J_ADVS}, author = {Shuanghai Wang and Kun He and Caitao Li and Yongkang Xu and Xingze Dai and Taikun Wang and Yu Liu and Yao Li and Yongbing Xu and Liang He}, doi = {10.1002/advs.202412409}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412409}, shortjournal = {Adv. Sci.}, title = {Enhancing field-like efficiency via interface engineering with sub-atomic layer ta insertion}, volume = {12}, year = {2025}, }
• (2025). In situ electron tomography insights into the curvature effect of a concave surface on fe single atoms for durable oxygen reaction. ADVS, 12(6), 2412387. (www)

  @article{ , abstract = {Curvature-induced interfacial electric field effects and local strain engineering offer a powerful approach for optimizing the intrinsic catalytic activity of single-atom catalysts (SACs). Investigations into the surface curvature on SACs are still ongoing, and the impact of the concave surface is often overlooked. In this work, theoretical calculations indicate that curved surfaces, particularly those with concavity, can optimize the electronic structures of single Fe sites and facilitate the reductive release of *OH. A carbon sphere featuring uniformly oriented channels and a chiral multi-shelled carbon hollow nanosphere are selected as carbon matrices due to their accessible concave and/or convex surfaces. After loading Fe species, the resulting catalysts with Fe SA in curved surfaces exhibit excellent oxygen reduction reaction activity ( E 1/2 = ≈0.89 V), strong methanol tolerance, and favorable long-term stability. Impressively, a solid-state flexible Zn–air battery based on this catalyst exhibits a remarkable durability over 40 h with a high peak power density of 122.1 mW cm −2 and excellent charge–discharge performance at different bending angles. This work offers in-depth insights into the rational design of carbon supports with highly curved surfaces, offering new opportunities for the microenvironmental regulation of SACs at the atomic level.}, archive = {J_ADVS}, author = {Jun-Kang Li and Haobo Zhao and Yang Zhang and Jing-Jing Ma and Fen-Fen Wang and Shu-Na Zhao and Jun Li and Shuang-Quan Zang}, doi = {10.1002/advs.202412387}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412387}, shortjournal = {Adv. Sci.}, title = {In situ electron tomography insights into the curvature effect of a concave surface on fe single atoms for durable oxygen reaction}, volume = {12}, year = {2025}, }
• (2025). Consumption of endogenous caspase-3 activates molecular theranostic nanoplatform against inflammation-induced profibrotic positive feedback in pulmonary fibrosis. ADVS, 12(6), 2412303. (www)

  @article{ , abstract = {The limited and backward diagnostic approaches elicit high mortality associated with pulmonary fibrosis (PF) because they fail to identify injury phase of PF. Developing a precisely theranostic nanoplatform presents a promising shortcut to reverse PF. Herein, a specific molecular nanotheranostic (Casp-GNMT), which is triggered by endogenous cysteinyl aspartate specific proteinase-3 (caspase-3), boosts antifibrotic efficacy through bioimaging synergistic with chemotherapy at molecular level, facilitating by ionizable lipid and reactive oxygen species sensitive lipid for precise and manageable therapy. The activation of molecular imaging probe (pCY-pairs) by consumption of endogenous caspase-3 initiates fluorescence resonance energy transfer-guided theranostic pattern, aiming to restore mitochondrial dysfunction-induced oxidative stress and inflammatory responses in alveolar epithelial cells II (AECs II). This process sequentially resists the expression of interleukin-1β and vascular endothelial growth factor receptor through combined with nintedanib, further suppressing abnormal injury of AECs II and persistent migration and proliferation of inflammatory cells. Especially, the homeostasis of injured AECs II diminishes excessive accumulation of transforming growth factor-β to restrain myofibroblasts proliferation and collagen deposition, thereby amplifying the possibility of reversing PF. This theranostic nanoplatform is proposed to provide a prompt and exact approach to enhance diagnostic authenticity and treating efficiency through harnessing endogenous indicator for PF reversal.}, archive = {J_ADVS}, author = {Qiu-Ling Li and Xin Chang and Yu-Mo Han and Zi-Chao Guo and Yi-Na Liu and Bin Guo and Chang Liu and Bin-Rong Yang and Zhong-Kai Fan and Hu-Lin Jiang}, doi = {10.1002/advs.202412303}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412303}, shortjournal = {Adv. Sci.}, title = {Consumption of endogenous caspase-3 activates molecular theranostic nanoplatform against inflammation-induced profibrotic positive feedback in pulmonary fibrosis}, volume = {12}, year = {2025}, }
• (2025). SREBP1c-mediated transcriptional repression of YME1L1 contributes to acute kidney injury by inducing mitochondrial dysfunction in tubular epithelial cells. ADVS, 12(6), 2412233. (www)

  @article{ , abstract = {Acute kidney injury (AKI) is a prevalent clinical syndrome with high morbidity and mortality. Accumulating studies suggest mitochondrial dysfunction as the typical characteristics and key process of AKI, but the underlying mechanism remains elusive. The YME1-like 1 (YME1L1) ATPase, an inner mitochondrial membrane protein, is screened and identified to be downregulated in renal tubular epithelial cells of various mouse models and patients of AKI. Dramatically, restoration of YME1L1 expression significantly alleviates cisplatin-induced AKI and subsequent chronic kidney disease (CKD) through attenuating mitochondrial dysfunction via maintaining optic atrophy 1 (OPA1)-mediated mitochondrial energy metabolism homeostasis. Mechanistically, the upregulated expression of sterol regulatory element binding transcription factor 1c (SREBP1c) is demonstrated to be responsible for cisplatin-mediated transcriptional inhibition of YME1L1 via directly binding to its promoter region. Moreover, cisplatin-induced methyltransferase-like 3 (METTL3)-mediated m6A modification enhances SREBP1c mRNA stability, thereby upregulating its expression. Notably, both depletion of SREBP1c and renal tubule-specific overexpression of YME1L1 markedly ameliorate cisplatin-induced AKI and its transition to CKD. Taken together, these findings suggest that METTL3-mediated SREBP1c upregulation contributes to AKI and its progression to CKD through disrupting mitochondrial energy metabolism via transcriptionally suppressing YME1L1. Targeting the SREBP1c/YME1L1 signaling may serve as a novel therapeutic strategy against AKI.}, archive = {J_ADVS}, author = {Wang Xin and Jie Zhou and Yuzhu Peng and Shuiqin Gong and Wenhao Liao and Yaqin Wang and Xixin Huang and Yang Mao and Mengying Yao and Shaozong Qin and Jiachuan Xiong and Yan Li and Qigang Lan and Yinghui Huang and Jinghong Zhao}, doi = {10.1002/advs.202412233}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412233}, shortjournal = {Adv. Sci.}, title = {SREBP1c-mediated transcriptional repression of YME1L1 contributes to acute kidney injury by inducing mitochondrial dysfunction in tubular epithelial cells}, volume = {12}, year = {2025}, }
• (2025). Diverse N-oxidation of primary aromatic amines controlled by engineered p450 peroxizyme variants facilitated by dual-functional small molecule. ADVS, 12(6), 2412100. (www)

  @article{ , abstract = {Amine oxidation is an important organic reaction for the production of high-value N -containing compounds. However, it is still challenging to control the reactivity of active N -centered radicals to selectively access N -oxidation products. Herein, this study reports the engineering of cytochrome P450BM3 into multifunctional N -oxidizing enzymes with the assistance of dual-functional small molecules (DFSM) to selectively produce N -oxygenation (i.e., p -nitrosobenzene, p -nitrobenzene, and azoxybenzene) and one-electron oxidation products (i.e., oligomeric quinones and azobenzene) from aromatic amines. The best mutant, F87A/T268V/V78T/A82T, exclusively gives p -nitrosobenzene (up to 98% selectivity), whereas the selectivity for p -nitrobenzene is >99% using the mutant F87A/T268V/A82T/I263L. Crystal structure analysis reveals that key mutations and DFSM exert synergistic effects on catalytic promiscuity by controlling the substrate orientation in active center. This study highlights the potential of DFSM-facilitated P450 peroxygenase and peroxidase for the synthesis of N -containing compounds via the controllable oxidation of aromatic amines, substantially expanding the chemical space of P450 enzymes.}, archive = {J_ADVS}, author = {Jie Chen and Fuquan Yao and Yiping Jiang and Xiangquan Qin and Mo Xian and Yingang Feng and Zhiqi Cong}, doi = {10.1002/advs.202412100}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412100}, shortjournal = {Adv. Sci.}, title = {Diverse N-oxidation of primary aromatic amines controlled by engineered p450 peroxizyme variants facilitated by dual-functional small molecule}, volume = {12}, year = {2025}, }
• (2025). 3D ordered macroporous mn, zr-doped CaCO3 nanomaterials for stable thermochemical energy storage. ADVS, 12(6), 2412082. (www)

  @article{ , abstract = {Developing high-performance Ca-based materials that can work for long-term heat transfer and storage in concentrated solar power plants is crucial to achieve the large-scale conversion of solar photon fluxes to dispatchable electricity. This work demonstrates that a series of Mn, Zr co-doped CaCO 3 nanomaterials with the 3D ordered macroporous (3DOM) skeletons are successfully prepared by a novel strategy of templated metal salt co-precipitation. The characterization results indicate that a majority of Zr and Mn are atomically dispersed into the highly-crystallized CaCO 3 framework, whereas a minor amount of Mn is present in the form of CaMnO 3 nanoparticles (NPs). The optimal 3DOM material made by templating with PS microspheres with a diameter of ≈350 nm, 3DOM-Ca80Mn10Zr10, shows a solar light absorptance of ≈74.1% and an initial energy storage density of 1706.4 kJ kg −1 . Importantly, it gives an impressive energy storage density loss of < 6.0% and maintains above 1600 kJ kg −1 after 125 cycles. The density functional theory calculations reveal that the co-doping of Mn and Zr into the CaO crystal lattice offers a strong affinity to [Ca 4 O 4 ] clusters, as a result, the anti-sintering of CaO NPs is significantly enhanced under high temperature.}, archive = {J_ADVS}, author = {Han Li and Jinfeng Lin and Jianze Wu and Jiashun Wang and Pengzhao Wang and Guojian Kang and Shuping Huang and Mingkai Fu and Jinjia Wei and Zhengxin Ding and Jinlin Long}, doi = {10.1002/advs.202412082}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2412082}, shortjournal = {Adv. Sci.}, title = {3D ordered macroporous mn, zr-doped CaCO3 nanomaterials for stable thermochemical energy storage}, volume = {12}, year = {2025}, }
• (2025). Nuclear overexpression of SAMHD1 induces m phase stalling in hepatoma cells and suppresses HCC progression by interacting with the cohesin complex. ADVS, 12(6), 2411988. (www)

  @article{ , abstract = {Emerging evidence suggests that the sterile alpha-motif (SAM) and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) is implicated in various cancers, including hepatocellular carcinoma (HCC). However, its precise role in tumor cells and the underlying mechanisms remain unclear. This study aimed to investigate the expression patterns, prognostic values, and functional role of SAMHD1 in HCC progression. We constructed liver tissue microarrays using tumor and paired paratumor tissue specimens from 187 patients with primary HCC. Our findings indicate that nuclear SAMHD1 protein levels are increased in tumors compared to paratumor tissues. Moreover, nuclear SAMHD1 levels decline in advanced tumor stages, with higher SAMHD1 nuclear staining correlating with favorable prognostic outcomes. Hepatocyte-specific SAMHD1 knockout mice, generated by crossing SAMHD1 fl/fl mice with Alb-cre mice, showed accelerated tumor progression in a diethylnitrosamine (DEN)-induced HCC model. In hepatoma cell lines, nuclear overexpression of SAMHD1 inhibited cell proliferation by stalling mitosis, independent of its deoxynucleotide triphosphohydrolase (dNTPase) function. Mechanistically, SAMHD1 interacts with the cohesin complex in nucleus, enhancing sister chromatid cohesion during cell division, which delays metaphase progression. Our findings suggest that nuclear SAMHD1 plays a critical role in slowing HCC progression by regulating mitosis, highlighting its potential as a therapeutic target by manipulating cohesin dynamics.}, archive = {J_ADVS}, author = {Juntang Shao and Wei Wang and Shiyu Li and Guangfa Yin and Lili Han and Xinyu Wang and Meng Cai and Tao Yang and Ying Wang and Wenyan Qu and Yanhong Jiao and Peng Wang and Hanyang Xu and Xu Zhu and Songcheng Ying and Sa Xu and Qiang Sheng and Jian Fang and Tongcui Jiang and Chuansheng Wei and Yujun Shen and Yuxian Shen}, doi = {10.1002/advs.202411988}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411988}, shortjournal = {Adv. Sci.}, title = {Nuclear overexpression of SAMHD1 induces m phase stalling in hepatoma cells and suppresses HCC progression by interacting with the cohesin complex}, volume = {12}, year = {2025}, }
• (2025). Symmetry breaking in rationally designed copper oxide electrocatalyst boosts the oxygen reduction reaction. ADVS, 12(6), 2411928. (www)

  @article{ , abstract = {Oxygen reduction reaction (ORR) kinetics is critically dependent on the precise modulation of the interactions between the key oxygen intermediates and catalytic active sites. Herein, a novel electrocatalyst is reported, featuring nitrogen-doped carbon-supported ultra-small copper oxide nanoparticles with the broken-symmetry C 4v coordination filed sites, achieved by a mild γ-ray radiation-induced method. The as-synthesized catalyst exhibits an excellent ORR activity with a half-wave potential of 0.873 V and shows no obvious decay over 50 h durability in alkaline solution. This superior catalytic activity is further corroborated by the high-performance in both primary and rechargeable Zn–air batteries with an ultrahigh-peak-power density (255.4 mW cm −2 ) and robust cycling stability. The experimental characterizations and density functional theory calculations show that the surface Cu atoms are configured in a compressed octahedron coordination. This geometric arrangement interacts with the key intermediate OH * , facilitating localized charge transfer and thereby weakening the Cu─O bond, which promotes the efficient transformation of OH * to OH − and the subsequent desorption, and markedly accelerates kinetics of the rate-determining step in the reaction. This study provides new insights for developing the utilization of γ-ray radiation chemistry to construct high-performance metal oxide-based catalysts with broken symmetry toward ORR.}, archive = {J_ADVS}, author = {Haoyu Peng and Weiyi Wang and Jiyuan Gao and Fan Jiang and Bowei Li and Yicheng Wang and Yiqian Wu and Yue Wang and Jiuqiang Li and Jing Peng and Wei Hu and Zhenhai Wen and Dingsheng Wang and Erhuan Zhang and Maolin Zhai}, doi = {10.1002/advs.202411928}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411928}, shortjournal = {Adv. Sci.}, title = {Symmetry breaking in rationally designed copper oxide electrocatalyst boosts the oxygen reduction reaction}, volume = {12}, year = {2025}, }
• (2025). Hypoxia microenvironment preconditioning attenuated myocardial ischemia-reperfusion injury via stc1-mediating cardiomyocyte self-protection and neutrophil polarization. ADVS, 12(6), 2411880. (www)

  @article{ , abstract = {Ischemic preconditioning (IPC) therapy application to attenuate myocardial ischemia-reperfusion (MI/R) injury in clinical practice remains challenging. The secretome, derived from hypoxia-preconditioned cardiomyocytes (SHPC), potentially mimics the IPC microenvironment and facilitates IPC clinical translation. This study aims to determine whether SHPC can be a feasible alternative to IPC for attenuating MI/R injury, and to identify the functional factor of SHPC. The ultrafiltration technique is applied to generate an SHPC formulation that is intramyocardially injected before reperfusion in a murine MI/R model. The effects of SHPC on cardiomyocyte apoptosis, pyroptosis, and neutrophil polarization are evaluated. Secretomics, neutralizing antibodies, and recombinant proteins are employed to identify the functional factor in SHPC. Co-immunoprecipitation assays, RNA sequencing, and site-directed mutagenesis are conducted to investigate the underlying mechanism. Additionally, a recombinant functional factor-encapsulated hydrogel is developed for intrapericardial injections (iPC). An intramyocardial SHPC injection in MI/R-injured mice strikingly reduces infarct size and the expression of cardiac injury biomarker while improving cardiac function. SHPC eliminated mitochondrial reactive oxygen species and triggered neutrophil polarization to reduce cardiomyocyte apoptosis/pyroptosis upon hypoxia/reoxygenation injury. Stanniocalcin 1 (Stc1) is identified as the functional factor in SHPC, mediating hypoxic microenvironment. Mechanistically, hypoxia-preconditioned cardiomyocytes secrete Stc1 into the microenvironment and activate calcium-sensing receptor (CaSR) that increases Stat3 phosphorylation at Ser727 via nitric oxide synthase 2 (NOS2)-mediated S-nitrosylation, thereby decreasing cardiomyocyte apoptosis/pyroptosis in an autocrine mechanism. Simultaneously, Stc1 facilitates cardiomyocyte-neutrophil crosstalk, thereby triggering neutrophil polarization to reduce inflammatory damage via the CaSR/NOS2/Stat3 axis in a paracrine mechanism. Pericardial delivery of a recombinant rStc1-encapsulated hydrogel has extended the therapeutic time window of rStc1, improving long-term cardiac function. The hypoxia microenvironment preconditioning, which mimicked by SHPC, attenuated MI/R injury via Stc1-mediated cardiomyocyte self-protection and neutrophil polarization. This study suggests that SHPC, with hypoxia preconditioning factor Stc1, represents a clinically feasible alternative to IPC for attenuating MI/R injury.}, archive = {J_ADVS}, author = {Haoxiang Huang and Yifei Ruan and Chuling Li and Hao Zheng and Yating Tang and Yijin Chen and Fengling He and Yu Liu and Guangkai Wu and Zhenhua Li and Yuegang Wang and Yulin Liao and Jianping Bin and Yanmei Chen}, doi = {10.1002/advs.202411880}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411880}, shortjournal = {Adv. Sci.}, title = {Hypoxia microenvironment preconditioning attenuated myocardial ischemia-reperfusion injury via stc1-mediating cardiomyocyte self-protection and neutrophil polarization}, volume = {12}, year = {2025}, }
• (2025). Entropy-mediated crystallization manipulation in glass. ADVS, 12(6), 2411861. (www)

  @article{ , abstract = {The entropy mediated temperature-structure evolution has attracted significant interest, which is used for the development of functional alloys and ceramics. But such strategy has not yet been demonstrated for development of non-metallic glasses. Herein, the successful application of the entropy engineering concept to non-metallic glass to manipulate its in situ crystallization process is demonstrated. The comparison of the entropy concept in alloys, ceramics, and non-metallic glass is discussed. As a typical example, the activation and preservation of the entropy stabilized effect of a typical niobosilicate glass system at different temperatures are studied. The relation between the micro-configurations and the entropic property is analyzed. Via the entropy engineering strategy, the crystallization of the niobosilicate glass can be manipulated. As a result, the LiNbO 3 nanocrystal-in-glass (NiG) composite with high crystallinity is developed, which exhibits 8 times higher nonlinearity compared with the β -BBO crystal. The developed NiG composite is demonstrated for practical application in precise measurement of the duration and phase of ultra-short femtosecond pulse.}, archive = {J_ADVS}, author = {Xu Feng and Guanfeng Gao and Quanhua Lin and Yongkang Yang and Jiajia Tan and Ziang Liu and Jianrong Qiu and Xiaofang Jiang and Shifeng Zhou}, doi = {10.1002/advs.202411861}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411861}, shortjournal = {Adv. Sci.}, title = {Entropy-mediated crystallization manipulation in glass}, volume = {12}, year = {2025}, }
• (2025). Constructing quasi-localized high-concentration solvation structures to stabilize battery interfaces in nonflammable phosphate-based electrolyte. ADVS, 12(6), 2411826. (www)

  @article{ , abstract = {Flame-retardant phosphate-based electrolytes effectively enhance lithium-ion battery safety but suffer from poor compatibility with graphite anodes and high-voltage cathodes, hindering scalability. Fluorinated phosphates, though widely used, increase interfacial resistance at the anode, degrading performance. In this work, carbonate solvents with strong polarity are introduced to prevent tris(2,2,2-trifluoroethyl) phosphate (TFEP) from participating in the solvation structure of lithium ions. This strategy forms a quasi-localized high-concentration solvation structure, thereby restricting the reduction of TFEP and its impact on the graphite anode. The LiNi 0.8 Mn 0.1 Co 0.1 O 2 (NCM811) | Graphite (Gr) pouch cell with optimized electrolyte exhibits a capacity retention rate of 80.1% after 370 cycles at 0.5C, which is much more stable than the electrolyte with TFEP-involved solvation structure (capacity retention rate: 47.1% after 300 cycles). The corresponding pouch cell with cut-off voltage to 4.5 V exhibits a capacity retention rate of 82.8% after 125 cycles, significantly outperforming cells employing commercial carbonate electrolytes (capacity retention rate: 56.9% after 125 cycles). Thus, the developed quasi-localized high-concentration solvation structure can effectively stabilize the electrode interface, greatly enhancing the cycling performance of phosphate-based flame-retardant electrolytes.}, archive = {J_ADVS}, author = {Chenyang Shi and Mengran Wang and Zari Tehrani and Bo Hong and Mengnan Wang and Rui Tan and Serena Margadonna and Yanqing Lai and Maria Magdalena Titirici}, doi = {10.1002/advs.202411826}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411826}, shortjournal = {Adv. Sci.}, title = {Constructing quasi-localized high-concentration solvation structures to stabilize battery interfaces in nonflammable phosphate-based electrolyte}, volume = {12}, year = {2025}, }
• (2025). Manipulating magnetic damping of Fe/GeTe heterostructures by band engineering. ADVS, 12(6), 2411798. (www)

  @article{ , abstract = {Understanding and manipulating magnetic damping, particularly in magnetic heterostructures, is crucial for fundamental research, versatile engineering, and optimization. Although magnetic damping can be enhanced by the band hybridization between ferromagnetic and nonmagnetic materials at the interface, the contribution of individual subbands on the hybridized bands to magnetic damping is fully unexplored. Here, it is found that magnetic damping α eff is modified by the Fermi level in Fe/GeTe heterostructures via Bi doping. By combining angle-resolved photoemission spectroscopy and density functional theory calculations, the enhancement of damping originated from the strongly hybridized band structures between Fe and the surface Rashba bands of GeTe are unveiled. More interestingly, the Fermi level modulates the density of states (DOS) ratio between the subbands of GeTe and the total DOS of hybridized states, which is directly proportional to the magnetic damping. This work gives an insightful physical understanding of the magnetic damping influenced by the hybridized band structures and opens a novel avenue to manipulate magnetic damping by band engineering.}, archive = {J_ADVS}, author = {Xu Yang and Jia-Wan Li and Yan Li and Liang Qiu and Hao-Pu Xue and Jin Tang and Hai-Feng Du and Rui Sun and Qing-Lin Yang and Jia-Nan Liu and Xiang-Qun Zhang and Wei He and Yusheng Hou and Zhao-Hua Cheng}, doi = {10.1002/advs.202411798}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411798}, shortjournal = {Adv. Sci.}, title = {Manipulating magnetic damping of Fe/GeTe heterostructures by band engineering}, volume = {12}, year = {2025}, }
• (2025). Ca2+- and cGAMP-contained semiconducting polymer nanomessengers for radiodynamic-activated calcium overload and immunotherapy. ADVS, 12(6), 2411739. (www)

  @article{ , abstract = {Various second messengers exert some vital actions in biological systems, including cancer therapy, but the therapeutic efficacy is often need to be improved. A semiconducting polymer nanomessenger (TCa/SPN/a) consisting of two second messengers, calcium ion (Ca 2+ ) and cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) for metastatic breast cancer therapy, is reported here. Such a TCa/SPN/a is constructed to exhibit X-ray response for the activatable delivery of mitochondria-targeting Ca compound and cGAMP as stimulator of interferon genes (STING) agonist. With X-ray irradiation, TCa/SPN/a could generate singlet oxygen ( 1 O 2 ) via radiodynamic effect for ablating solid tumors and improving the tumor immunogenicity by inducing immunogenic cell death (ICD). Furthermore, the released mitochondria-targeting Ca compounds show a high binging effect on mitochondria and cause reactive oxygen species (ROS) generation and mitochondria damage via calcium overload, while cGAMP boosts immunological effect through activating STING pathway. In this way, TCa/SPN/a enables a radiodynamic-activated calcium overload and immunotherapy to obviously inhibit the growths of bilateral tumors and also abolish tumor metastasis in metastatic breast cancer mouse models. This article should demonstrate the first smart dual-functional nanotherapeutic containing two second messengers for precise and specific cancer therapy.}, archive = {J_ADVS}, author = {Danling Cheng and Libai Luo and Qin Zhang and Zheming Song and Yiduo Zhan and Wenzhi Tu and Jingchao Li and Qiming Ma and Xianchang Zeng}, doi = {10.1002/advs.202411739}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411739}, shortjournal = {Adv. Sci.}, title = {Ca2+- and cGAMP-contained semiconducting polymer nanomessengers for radiodynamic-activated calcium overload and immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Wearable temperature sensor enhanced volatilomics technique for swift and convenient detection of latrogenic botulism. ADVS, 12(6), 2411738. (www)

  @article{ , abstract = {Accurately assessing potential side effects following botulinum neurotoxin (BoNT) injection remains a formidable challenge. To address this issue, an innovative approach is developed that combines a wearable temperature sensor with a sophisticated volatilomics technique, aimed at facilitating the rapid and convenient prediction of potential physical discomfort related to latrogenic botulism. The investigation identifies five volatile organic compounds (VOCs)—acetone, styrene, ethanol, 2-pentanone, and n-butano—as promising markers indicative of BoNT poisoning. Specifically, a handheld breath analyzer, featuring a yttrium stabilized zirconia (YSZ)-based gas sensor array, alongside a wearable temperature sensor integrated with a bio-compatible methacrylated gelatin (GelMA) sensing film, are developed to simultaneously monitor breath signal variations and body temperature fluctuations. Preliminary animal testing validates the effectiveness of the integrated approach, achieving an accuracy exceeding 91.2% in early detection of physical discomfort associated with BoNT poisoning. These promising findings represent a significant advancement towards the early identification of BoNT-related issues, enabling timely intervention and improved management strategies.}, archive = {J_ADVS}, author = {Xiaoyang Li and Yufei Yan and Chenyi Hu and Jing Wang and Jinlin Wang and Hao Yang and Daxiang Cui and Wenwen Xin and Shan Gao and Han Jin}, doi = {10.1002/advs.202411738}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411738}, shortjournal = {Adv. Sci.}, title = {Wearable temperature sensor enhanced volatilomics technique for swift and convenient detection of latrogenic botulism}, volume = {12}, year = {2025}, }
• (2025). A heparan sulfate mimetic RAFT copolymer inhibits SARS-CoV-2 infection and ameliorates viral-induced inflammation. ADVS, 12(6), 2411737. (www)

  @article{ , abstract = {The high transmissibility and mutation ability of coronaviruses enable them to easily escape existing immune protection and also pose a challenge to existing antiviral drugs. Moreover, drugs only targeting viruses cannot always attenuate the “cytokine storm”. Herein, a synthetic heparan sulfate (HS) mimetic, HMSA-06 is reported, that exhibited antiviral activities against both the SARS-CoV-2 prototype and Omicron strains by targeting viral entry and replication. Of particular note, HMSA-06 demonstrated more potent anti-SARS-CoV-2 effects than PG545 and Roneparstat. SARS-CoV-2 is reported to hijack autophagy to facilitate its replication, therefore boosting autophagy can attenuate SARS-CoV-2 infection. It is revealed that HMSA-06, but not a similar HS mimetic that failed to inhibit SARS-CoV-2, can upregulate cellular autophagy flux. In addition, HMSA-06 was found to robustly block the NLRP3-mediated inflammatory reaction in SARS-CoV-2 infected THP-1 derived macrophages as evidenced by a reduction in inflammasome formation and the subsequent decreased secretion of mature caspase-1 and IL-1β. The HMSA-06's inflammation inhibitory function is further confirmed using a LPS/ATP-stimulated THP-1 macrophage model. Altogether, this study has identified a promising HS mimetic to combat SARS-CoV-2-associated diseases by inhibiting viral infection and attenuating viral-induced inflammatory reaction, providing insights into the development of novel anti-coronavirus drugs in the future.}, archive = {J_ADVS}, author = {Jiaxin Ling and Åke Lundkvist and Marco Guerrini and Vito Ferro and Jin-Ping Li and Jinlin Li}, doi = {10.1002/advs.202411737}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411737}, shortjournal = {Adv. Sci.}, title = {A heparan sulfate mimetic RAFT copolymer inhibits SARS-CoV-2 infection and ameliorates viral-induced inflammation}, volume = {12}, year = {2025}, }
• (2025). PD-1-enhanced treg cell senescence in advanced maternal age. ADVS, 12(6), 2411613. (www)

  @article{ , abstract = {Senescence occurs earlier in the immune system than in solid organs as age increases. Regulatory T (Treg) cells are among the first cells to exhibit signs of aging. However, whether advanced-age pregnancy involves Treg cell aging remains unclear. This study demonstrated that the aging of women is accompanied by aging Treg cells and that PD-1 regulates Treg cell aging. The transfer of young Treg cells can improve the pregnancy outcomes of reproductive-aged mice by reducing the level of IFN-γ, a proinflammatory cytokine secreted by Treg cells in aged mice. Transferring α-PD-1 mAb-treated aged Treg cells increases the level of IL-10, an anti-inflammatory cytokine secreted by Treg cells in reproductive-aged mice. Collectively, these findings suggest a potential therapeutic strategy for preventing adverse pregnancy outcomes in older women.}, archive = {J_ADVS}, author = {Guang-Shun Gong and Yu-Jing Zhang and Xiao-Hui Hu and Xin-Xiu Lin and Ai-Hua Liao}, doi = {10.1002/advs.202411613}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411613}, shortjournal = {Adv. Sci.}, title = {PD-1-enhanced treg cell senescence in advanced maternal age}, volume = {12}, year = {2025}, }
• (2025). Development of a sealed rechargeable Li–SO2 battery. ADVS, 12(6), 2411598. (www)

  @article{ , abstract = {Rechargeable Li–SO 2 batteries offer low-cost, high-energy density benefits and can leverage manufacturing processes for the existing primary version at a commercial scale. However, they have so far only been demonstrated in an “open-system” with continuous gas supply, preventing practical application. Here, the utilization and reversibility of SO 2 along with the lithium stability are addressed, all essential for long-life, high-energy batteries. The study discovers that high SO 2 utilization is achievable only from SO 2 dissolved in electrolytes between the lithium anode and carbon cathode. This results from a unique osmosis phenomenon where SO 2 consumption increases salt concentration, driving the influx of organic solvents rather than SO 2 from outside the current path. This insight leads to configure a bobbin-cell with all electrolytes between the electrodes, realizing nearly 70% of SO 2 utilization, > 12x greater than in conventional coin cells. To improve reaction rate and SO 2 reversibility, triphenylamine is employed to the electrolyte, creating an electron-rich environment that alleviates the disproportionation of discharge products. Incorporating this additive into a bobbin-cell with a lithium protective layer yields a cell with a projected energy density exceeding 183.2 Wh kg −1 . The work highlights the potential of Li–SO 2 batteries as affordable, sustainable energy storage options.}, archive = {J_ADVS}, author = {Gayea Hyun and Myeong Hwan Lee and Haodong Liu and Shen Wang and Zeyu Hui and Victoria Petrova and Ping Liu}, doi = {10.1002/advs.202411598}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411598}, shortjournal = {Adv. Sci.}, title = {Development of a sealed rechargeable Li–SO2 battery}, volume = {12}, year = {2025}, }
• (2025). Thermosensitive hydrogel integrated with bimetallic nano-enzymes for modulating the microenvironment in diabetic wound beds. ADVS, 12(6), 2411575. (www)

  @article{ , abstract = {Effective regulation and reconstruction of the microenvironment are critical for the regeneration of chronic wounds. Diabetic wounds, in particular, pose a significant clinical challenge due to increased oxidative stress and dysfunctional healing processes. In this study, a novel therapeutic strategy is developed using 3D copper-magnesium bimetallic antioxidant nano-enzymes (Cu/Mg-MOF) to mitigate reactive oxygen species (ROS) and restore redox balance through electron transfer. To optimize delivery, a thermo-sensitive hydrogel composed of chitosan (CS) and ε -polylysine (PL) is designed, serving as an efficient carrier for the nano-enzymes. This Cu/Mg-MOF@CS/PL hydrogel exhibits excellent physical properties, including injectability, softness, and biocompatibility, making it ideal for application in diabetic wounds. In a diabetic wound model, treatment with Cu/Mg-MOF@CS/PL hydrogel significantly accelerated wound healing, with a closure rate of 90.6% by day 14, compared to just 55.4% in the untreated group. The hydrogel effectively promoted key aspects of wound healing, such as collagen deposition, re-epithelialization, angiogenesis, and immunomodulation. These findings underscore the potential of the Cu/Mg-MOF@CS/PL hydrogel as a promising therapeutic system for enhancing the healing of diabetic wounds.}, archive = {J_ADVS}, author = {Chuwei Zhang and Xiaoyi Zhang and Fei Li and Bo Li and Mengnan Zhang and Wanqian Li and Pan Zhuge and Jingye Yao and Yi Zhang and Shixuan Chen and Yongjin Fang and Chao Cai}, doi = {10.1002/advs.202411575}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411575}, shortjournal = {Adv. Sci.}, title = {Thermosensitive hydrogel integrated with bimetallic nano-enzymes for modulating the microenvironment in diabetic wound beds}, volume = {12}, year = {2025}, }
• (2025). Addressing clinical limitations of glutaminase inhibitors: Novel strategies for osimertinib-resistant lung cancer by exploiting glutamine metabolic dependency. ADVS, 12(6), 2411479. (www)

  @article{ , abstract = {Overcoming acquired resistance to Osimertinib remains a critical challenge in treating NSCLC. This research indicates that Osimertinib-resistant cells exhibit a strong dependence on glutamine metabolism. However, targeting GLS1 shows limited anticancer effects, probably because it cannot fully block the glutamine metabolic pathway. The investigation reveals that a more effective strategy involves simultaneously inhibiting both ASCT2 and GLS1. After confirming the efficacy of this dual-targeting approach against Osimertinib-resistant cells in preclinical models, the potential of utilizing a broad-spectrum glutamine metabolism antagonist is further explored to achieve superior antitumor efficacy. DON, broad-spectrum glutamine antagonist, presents toxicity issues. Herein, the high NQO1 expression in Osimertinib-resistant NSCLC cells is leveraged to design an NQO1-responsive DON prodrug, 10e (LBJ-10e). This prodrug demonstrates superior safety compared to natural DON and greater antitumor activity against resistant tumors compared to the clinical phase II drug DRP104. These findings may address the clinical limitations of GLS1 allosteric inhibitors and underscore prodrug strategies in effectively treating Osimertinib-resistant lung cancer, providing a foundation for future clinical trials.}, archive = {J_ADVS}, author = {Jiali Huang and Xiankang Zhang and Hui Zhang and Yu Li and Huidan Huang and Zhiyu Li and Zhixia Qiu and Hongxi Wu and Dechun Huang and Xi Xu and Jinlei Bian}, doi = {10.1002/advs.202411479}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411479}, shortjournal = {Adv. Sci.}, title = {Addressing clinical limitations of glutaminase inhibitors: Novel strategies for osimertinib-resistant lung cancer by exploiting glutamine metabolic dependency}, volume = {12}, year = {2025}, }
• (2025). Precise tuning of flexoelectricity in SrTiO3 by ion irradiation. ADVS, 12(6), 2411391. (www)

  @article{ , abstract = {Flexoelectric coefficient is a tetradic and its introduction enables centrosymmetric materials to exhibit piezoelectricity. However, the flexoelectric paradigm currently lacks a strategy to effectively tune the strain gradient for optimal electro-mechanical coupling. This study proposes a quantized collision model accessible through ionic irradiation technology to explore the flexoelectricity and precisely modulate the strain gradient. The lattice strain is introduced in SrTiO 3 (STO) single crystals and tuned broadly by irradiation with ions of He + , C + , and P + at dose of 1 × 10 14 and 2 × 10 15 ion cm −2 , respectively. Under C + ion irradiation at a dose of 2 × 10 15 ion cm −2 , thin-film X-ray diffraction reveals a strain gradient up to ≈0.65% nm −1 . The resulted polarization is found to orient out-of-plane, as observed through X-ray reciprocal space mapping and high-angle annular dark field scanning transmission electron microscopy. Piezoresponse force microscopy characterization reveals that the electric-induced out-of-plane polarization reversal emerges at room temperature, corresponding to a stain gradient ≈0.05% nm −1 in STO's flexoelectric response. This study demonstrates that ion irradiation is an effective strategy for precisely tuning the flexoelectric properties.}, archive = {J_ADVS}, author = {Shuai Nan and Shipu Xu and Yunlong Ren and Xin Yuan and Yuhua Ma and Pengfei Zhai and Fuxiang Zhang}, doi = {10.1002/advs.202411391}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411391}, shortjournal = {Adv. Sci.}, title = {Precise tuning of flexoelectricity in SrTiO3 by ion irradiation}, volume = {12}, year = {2025}, }
• (2025). AI-guided inverse design and discovery of recyclable vitrimeric polymers. ADVS, 12(6), 2411385. (www)

  @article{ , abstract = {Vitrimer is a new, exciting class of sustainable polymers with healing abilities due to their dynamic covalent adaptive networks. However, a limited choice of constituent molecules restricts their property space and potential applications. To overcome this challenge, an innovative approach coupling molecular dynamics (MD) simulations and a novel graph variational autoencoder (VAE) model for inverse design of vitrimer chemistries with desired glass transition temperature ( T g ) is presented. The first diverse vitrimer dataset of one million chemistries is curated and T g for 8,424 of them is calculated by high-throughput MD simulations calibrated by a Gaussian process model. The proposed VAE employs dual graph encoders and a latent dimension overlapping scheme which allows for individual representation of multi-component vitrimers. High accuracy and efficiency of the framework are demonstrated by discovering novel vitrimers with desirable T g beyond the training regime. To validate the effectiveness of the framework in experiments, vitrimer chemistries are generated with a target T g = 323 K. By incorporating chemical intuition, a novel vitrimer with T g of 311–317 K is synthesized, experimentally demonstrating healability and flowability. The proposed framework offers an exciting tool for polymer chemists to design and synthesize novel, sustainable polymers for various applications.}, archive = {J_ADVS}, author = {Yiwen Zheng and Prakash Thakolkaran and Agni K. Biswal and Jake A. Smith and Ziheng Lu and Shuxin Zheng and Bichlien H. Nguyen and Siddhant Kumar and Aniruddh Vashisth}, doi = {10.1002/advs.202411385}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411385}, shortjournal = {Adv. Sci.}, title = {AI-guided inverse design and discovery of recyclable vitrimeric polymers}, volume = {12}, year = {2025}, }
• (2025). Mesenchymal stem cells prevent SLC39A14-dependent hepatocyte ferroptosis through exosomal miR-16-5p in liver graft. ADVS, 12(6), 2411380. (www)

  @article{ , abstract = {Ischemia-reperfusion injury (IRI) is the leading cause of hepatic graft dysfunction, resulting from hepatocyte damage. Nevertheless, given the few specialized therapeutics available in hepatic IRI, additional mechanistic insights into hepatocyte damage are required. Here, the protein solute carrier family 39 member 14 (SLC39A14) is identified as a pro-ferroptosis target in hepatocytes of human liver allografts through single-cell RNA sequencing analysis. SLC39A14 knockdown significantly mitigated hepatic IRI by preventing hepatocyte ferroptosis in vivo and in vitro. Mechanistically, the inhibition of SLC39A14 suppressed non-transferrin-bound iron (NTBI) uptake by hepatocytes, thereby reducing iron overload and cell ferroptosis. Moreover, human bone marrow-derived mesenchymal stem cells (hBMSCs) are found to exhibit a notable therapeutic effect on hepatic IRI by downregulating SLC39A14 expression. Exosomes derived from hBMSCs delivered abundant miR-16-5p into hepatocytes, which post-transcriptionally suppressed the expression of SLC39A14 and reduced cell ferroptosis induced by hepatic IRI. In conclusion, SLC39A14 triggers hepatic IRI by mediating NTBI uptake into hepatocytes and inducing hepatocyte ferroptosis. Moreover, hBMSC-based therapy is promising to reverse this progression of hepatic IRI.}, archive = {J_ADVS}, author = {Zhizhao Deng and Weiqi Zeng and Yingxin Gao and Zhenyu Yang and Xinling Luo and Xianlong Li and Guoliang Sun and Erfeng Xiong and Fei Huang and Gangjian Luo and Ziqing Hei and Dongdong Yuan}, doi = {10.1002/advs.202411380}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411380}, shortjournal = {Adv. Sci.}, title = {Mesenchymal stem cells prevent SLC39A14-dependent hepatocyte ferroptosis through exosomal miR-16-5p in liver graft}, volume = {12}, year = {2025}, }
• (2025). Continuous flow photoelectrochemical reactor with gas permeable photocathode: Enhanced photocurrent and partial current density for CO2 reduction. ADVS, 12(6), 2411348. (www)

  @article{ , abstract = {Photoelectrochemical (PEC) CO 2 reduction using a photocathode is an attractive method for making valuable chemical products due to its simplicity and lower overpotential requirements. However, previous PEC processes have often been diffusion-limited leading to low production rates of the CO 2 reduction reaction, due to inefficient gas diffusion through the liquid electrolyte to the catalyst surface, particularly at high current densities. In this study, a gas-permeable photocathode in a continuous flow PEC reactor is incorporated, which facilitates the direct supply of CO 2 gas to the photocathode-electrolyte interface, unlike dark reaction-based flow reactors. This concept is demonstrated using Ag-TiO 2 on carbon paper, illuminated through a quartz window and flowing liquid electrolyte. CO 2 supply is managed via pressure and flow control on the non-illuminated side of the carbon paper. The photocurrent density is significantly influenced by the flow rates and pressure of CO 2 gas, and the electrolyte flow rates. Compared to the traditional H-cell, the continuous PEC flow reactor achieves ≈10-fold increase in CO faradaic efficiency, 30-fold increase in production rate and 16-fold increase in stability without catalyst modifications. This work provides essential insights into the design and application of continuous gas-liquid flow PEC reactor systems, highlighting their potential for other PEC reactions.}, archive = {J_ADVS}, author = {Hyunju Jung and Aqil Jamal and Issam Gereige and Tan Tien Nguyen and Joel W. Ager and Hee-Tae Jung}, doi = {10.1002/advs.202411348}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411348}, shortjournal = {Adv. Sci.}, title = {Continuous flow photoelectrochemical reactor with gas permeable photocathode: Enhanced photocurrent and partial current density for CO2 reduction}, volume = {12}, year = {2025}, }
• (2025). Electrochemical control of the ultrafast lattice response of a layered semimetal. ADVS, 12(6), 2411344. (www)

  @article{ , abstract = {The unique layer-stacking in two-dimensional (2D) van der Waals materials facilitates the formation of nearly degenerate phases of matter and opens novel routes for the design of low-power, reconfigurable functional materials. Electrochemical ion intercalation between stacked layers offers a promising approach to stabilize bulk metastable phases and to explore the effects of extreme carrier doping and strain. However, in situ characterization methods to study the structural evolution and dynamical functional properties of these intercalated materials remains limited. Here a novel experimental platform is presented capable of simultaneously performing electrochemical lithium-ion intercalation and multimodal ultrafast characterization of the lattice using both electron diffraction and nonlinear optical techniques. Using the layered semimetal WTe 2 as a model system, the interlayer shear phonon mode that modulates stacking between 2Dlayers is probed, showing that small amounts of lithiation enhance the amplitude and lifetime of the phonon, contrary to expectations. This results from the dynamically fluctuating and anharmonic structure between nearly degenerate phases at room temperature, which can be stabilized by electronic carriers accompanying the inserted lithium ions. At high lithiation, the T d ’ structure emerges and quenches the phonon response. This work defines new approaches for using electrochemistry to engineer the dynamic structure of 2D materials.}, archive = {J_ADVS}, author = {Felipe A. de Quesada and Philipp K. Muscher and Eliana S. Krakovsky and Aditya Sood and Andrey D. Poletayev and Edbert J. Sie and Clara M. Nyby and Sara J. Irvine and Marc E. Zajac and Duan Luo and Xiaozhe Shen and Matthias C. Hoffmann and Patrick L. Kramer and R. Joel England and Alexander H. Reid and Stephen P. Weathersby and Leora E. Dresselhaus-Marais and Daniel A. Rehn and William C. Chueh and Aaron M. Lindenberg}, doi = {10.1002/advs.202411344}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411344}, shortjournal = {Adv. Sci.}, title = {Electrochemical control of the ultrafast lattice response of a layered semimetal}, volume = {12}, year = {2025}, }
• (2025). Hybrid cell membrane-engineered nanocarrier for triple-action strategy to address pseudomonas aeruginosa infection. ADVS, 12(6), 2411261. (www)

  @article{ , abstract = {Bacterial infections resistant to antimicrobial treatments, particularly those caused by Pseudomonas aeruginosa ( P. aeruginosa ), frequently lead to elevated mortality rates. Tackling this resistance using therapeutic combinations with varied mechanisms has shown considerable promise. In this study, a bioinspired nanocarrier is successfully designed and engineered for targeted antibiotic delivery and toxin/bacteria clearance. This is achieved by encapsulating antibiotic-loaded framework nucleic acids with hybrid cell membranes acquired from neutrophils and platelets. By coating the hybrid membrane outside the shell, nanocarriers are endowed with the function of neutrophil-like chemotaxis and platelet-like bacteria adhesion to achieve the first stage of inflammation targeting. Based on the specific binding of bacteria toxin to the hybrid membrane, the release of antibiotic-loaded framework nucleic acids is triggered by toxin-mediated membrane lysis to fulfill the second stage of toxin neutralization and bacteria killing. Meanwhile, the immunomodulation potential of framework nucleic acids enables nanocarriers to accomplish the third stage of reversing the immunosuppressive microenvironment. In mouse models of acute and chronic P. aeruginosa pneumonia, the nanocarriers can reduce bacterial burden at a low dosage and decrease mortality with negligible toxicity. In sum, these findings have illustrated the remarkable capability of nanocarriers in treating recalcitrant bacterial infections.}, archive = {J_ADVS}, author = {Shunhao Zhang and Tianyu Chen and Weitong Lu and Yunfeng Lin and Mi Zhou and Xiaoxiao Cai}, doi = {10.1002/advs.202411261}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411261}, shortjournal = {Adv. Sci.}, title = {Hybrid cell membrane-engineered nanocarrier for triple-action strategy to address pseudomonas aeruginosa infection}, volume = {12}, year = {2025}, }
• (2025). Hierarchical targeting nanodrug with holistic DNA protection for effective treatment of acute kidney injury. ADVS, 12(6), 2411254. (www)

  @article{ , abstract = {Acute kidney injury (AKI) manifests a hallmark pathological feature of extensive and severe DNA damage in renal tubules, primarily induced by the excessive of toxic reactive oxygen species (ROS) from the mitochondrial electron transport chain. The kidney's complex intricate physiological architecture and the heterogeneous intracellular environment pose significant challenges for effective sequential and high-resolution drug delivery—an urgent issue that remains unresolved. To address this, a hierarchical-targeting antioxidant nanodrug has been developed with a folic acid moiety (HAND) designed for high-resolution drug delivery in AKI treatment. For the first time, HAND enables sequential targeting from the kidney to the most severely damaged proximal tubular epithelial cells (PTECs), ultimately concentrating in the DNA-rich mitochondria and nucleus. As a result, HAND effectively scavenges ROS in situ, protecting both mitochondria and nuclei along with their vital genetic material. This action restores mitochondrial function, mitigates DNA oxidation and fragmentation, reduces apoptosis, and inhibits cGAS/STING-mediated sterile inflammation. Consequently, HAND demonstrates remarkable efficacy in safeguarding injured kidneys during AKI. Overall, this work pioneers a hierarchical, high-resolution antioxidant strategy, providing innovative guidance for the development of AKI therapies.}, archive = {J_ADVS}, author = {Qiaohui Chen and Yongqi Yang and Xiaohong Ying and Changkun Huang and Jianlin Chen and Jue Wang and Ziyu Wu and Wan Zeng and Chenxi Miao and Xiaojing Shi and Yayun Nan and Qiong Huang and Kelong Ai}, doi = {10.1002/advs.202411254}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2411254}, shortjournal = {Adv. Sci.}, title = {Hierarchical targeting nanodrug with holistic DNA protection for effective treatment of acute kidney injury}, volume = {12}, year = {2025}, }
• (2025). SYISL knockout promotes embryonic muscle development of offspring by modulating maternal gut microbiota and fetal myogenic cell dynamics. ADVS, 12(6), 2410953. (www)

  @article{ , abstract = {Embryonic muscle fiber formation determines post-birth muscle fiber totals. The previous research shows SYISL knockout significantly increases muscle fiber numbers and mass in mice, but the mechanism remains unclear. This study confirms that the SYISL gene, maternal gut microbiota, and their interaction significantly affect the number of muscle fibers in mouse embryos through distinct mechanisms, as SYISL knockout alters maternal gut microbiota composition and boosts butyrate levels in embryonic serum. Both fecal microbiota transplantation and butyrate feeding significantly increase muscle fiber numbers in offspring, with butyrate inhibiting histone deacetylases and increasing histone acetylation in embryonic muscle. Combined analysis of RNA-seq between wild-type and SYISL knockout mice with ChIP-seq for H3K9ac and H3K27ac reveals that SYISL and maternal microbiota interaction regulates myogenesis via the butyrate-HDAC-H3K9ac/H3K27ac pathway. Furthermore, scRNA-seq analysis shows that SYISL knockout alone significantly increases the number and proportion of myogenic cells and their dynamics, independently of regulating histone acetylation levels. Cell communication analysis suggests that this may be due to the downregulation of signaling pathways such as MSTN and TGFβ. Overall, multiple pathways are highlighted through which SYISL influences embryonic muscle development, offering valuable insights for treating muscle diseases and improving livestock production.}, archive = {J_ADVS}, author = {Hao Zuo and Wei Jiang and Jianwei Gao and Zhibo Ma and Chen Li and Yaxin Peng and Jianjun Jin and Xizhen Zhan and Wei Lv and Xiao Liu and Jingjing Hu and Mengdi Zhang and Yiming Jia and Zaiyan Xu and Junming Tang and Rong Zheng and Bo Zuo}, doi = {10.1002/advs.202410953}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410953}, shortjournal = {Adv. Sci.}, title = {SYISL knockout promotes embryonic muscle development of offspring by modulating maternal gut microbiota and fetal myogenic cell dynamics}, volume = {12}, year = {2025}, }
• (2025). Unveiling the origin of the strengthening mechanism in a novel precious metal multi-principal elements alloy. ADVS, 12(6), 2410936. (www)

  @article{ , abstract = {Precious metal electrical contact materials are pivotal in microelectronic devices due to their excellent chemical stability and electrical properties. Their practical application is hindered by the strength, contact resistance, and high cost. Multi-principal elements alloys (MPEAs) provide the possibility to develop cost-effective materials with enhanced mechanical properties. To address this, a novel precious metal MPEA, PdAgCuAuPtZn alloy, is designed, which exhibits significant solid solution strengthening and aging strengthening effects. The ultimate tensile strength increases from 747 MPa in the solution state to 1126 MPa in the aged state, while resistivity remains low. This study presents the first systematic investigation into the strengthening mechanisms of precious metal MPEAs using nanoindentation technology. These findings indicate that the aging strengthening of the alloy is attributed to spinodal decomposition (SD) and chemical short-range order (CSRO) in the matrix. Furthermore, the precipitation structure with Cu-rich and Ag-rich phases gradually replaces the matrix, primarily accounting for aging softening. Additionally, it is discovered that precipitation structure can be strengthened by CSRO formed in the Cu-rich phase, thus providing an innovative strengthening in PdAgCuAuPtZn alloy. These results will be beneficial to both deeply understanding the aging behaviors of PdAgCuAuPtZn alloys and designing high-performance precious metal MPEAs.}, archive = {J_ADVS}, author = {Xuan Zhou and Hualong Ge and Kai Xiong and Junjie He and Shunmeng Zhang and Li Fu and Zhilong Tan and Xiaofei Wu and Xuming Li and Haijun Wu and Junmei Guo and Yong Mao}, doi = {10.1002/advs.202410936}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410936}, shortjournal = {Adv. Sci.}, title = {Unveiling the origin of the strengthening mechanism in a novel precious metal multi-principal elements alloy}, volume = {12}, year = {2025}, }
• (2025). A hierarchical Metal–Organic framework intensifying ROS catalytic activity and bacterial entrapment for engineering self-antimicrobial mask. ADVS, 12(6), 2410703. (www)

  @article{ , abstract = {Leveraging functional materials to develop advanced personal protective equipment is of significant importance for cutting off the propagation of infectious diseases, yet faces ongoing challenges owing to the unsatisfied antimicrobial efficiency. Herein a hierarchically porous cerium metal–organic framework (Ce-MOF) boosting the antimicrobial performance by intensifying catalytic reactive oxygen species (ROS) generation and bacterial entrapment simultaneously is reported. This Ce-MOF presents dendritic surface topography and hierarchical pore channels where the Lewis acid Ce sites are dispersedly anchored. Attributing to this sophisticated nanoarchitecture rendering the catalytic Ce sites highly accessible, it shows a ca. 1800-fold activity enhancement for the catalytic conversion of atmospheric oxygen to highly toxic ROS compared to traditional CeO 2 . Additionally, the dendritic and negative-charged surface engineered in this Ce-MOF substantially enhances the binding affinity toward positive-charged bacteria, enabling the spatial proximity between the bacteria and the short-lived ROS and therefore maximizing the utilization of highly toxic ROS to inactivate bacteria. It is demonstrated that this Ce-MOF-integrated face mask displays almost 100% antimicrobial efficacy even in insufficient light and dark scenarios. This work provides important insights into the design of antibacterial MOF materials by a pore- and surface-engineering strategy and sheds new light on the development of advanced self-antimicrobial devices.}, archive = {J_ADVS}, author = {Wei Huang and Haitao Yuan and Huangsheng Yang and Yujian Shen and Lihong Guo and Ningyi Zhong and Tong Wu and Yong Shen and Guosheng Chen and Siming Huang and Li Niu and Gangfeng Ouyang}, doi = {10.1002/advs.202410703}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410703}, shortjournal = {Adv. Sci.}, title = {A hierarchical Metal–Organic framework intensifying ROS catalytic activity and bacterial entrapment for engineering self-antimicrobial mask}, volume = {12}, year = {2025}, }
• (2025). Photocatalytic partial water oxidation promoted by a hydrogen acceptor-hydroxyl mediator couple. ADVS, 12(6), 2410680. (www)

  @article{ , abstract = {Hydrogen peroxide (H 2 O 2 ) is an important chemical in synthetic chemistry with huge demands. Photocatalytic synthesis of H 2 O 2 via oxygen reduction and water oxidation reactions (ORR and WOR) is considered as a promising and desirable solution for on-site applications. However, the efficiency of such a process is low due to the poor solubility of molecular oxygen and the rapid reverse reaction of hydroxyl radicals ( • OH) with hydrogen atoms (H). Here, a strategy is proposed to boost the H 2 O 2 evolution via oxidation of water by employing a H acceptor ( A , nitrocyclohexane), an • OH mediator ( M , dioxane), and a photocatalyst (CdS nanosheets). While • OH radicals are stabilized by dioxane to produce ketyl radicals prior to the formation of H 2 O 2 , H atoms are effectively utilized in the generation of cyclohexanone oxime, an important intermediate in the production of Nylon 6. The system displays a rapid kinetic accumulation of H 2 O 2 (0.13 min −1 ) to a high concentration (6.6 m M ). At optimum reaction conditions, a high quantum efficiency (16.6%) and light-to-chemical conversion efficiency (4.9%) can be achieved under 410 nm irradiation.}, archive = {J_ADVS}, author = {Yuanqiang Mai and Dongsheng Zhang and Kristina Maliutina and Xueyang Leng and Nengjun Cai and Jialu Li and Chao Wang and Yu Huang and Kai Zhang and Wujun Zhang and Yongwang Li and Flemming Besenbacher and Hans Niemantsverdriet and Wenting Liang and Yanbin Shen and Tingbin Lim and Emma Richards and Ren Su}, doi = {10.1002/advs.202410680}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410680}, shortjournal = {Adv. Sci.}, title = {Photocatalytic partial water oxidation promoted by a hydrogen acceptor-hydroxyl mediator couple}, volume = {12}, year = {2025}, }
• (2025). Combined exsolution and electrodeposition strategy for enhancing electrocatalytic activity of ti-based perovskite oxides in oxygen and hydrogen evolution reactions. ADVS, 12(6), 2410535. (www)

  @article{ , abstract = {The significant interest in perovskite oxides stems from their compositional and structural flexibility, particularly in the field of electrochemistry. In this study, the double E strategy (exsolution and electrodeposition strategies) is successfully devised for synthesizing perovskite-based bifunctional electrocatalysts, enabling simultaneous OER and HER applications with exceptional catalytic performance. The synthesized R-LCTFe/Ni catalyst exhibits outstanding electrocatalytic activity, delivering low overpotentials of 349 and 309 mV at 10 mA cm −2 for OER and HER, respectively, indicating substantial improvements in the inherent electrocatalytic activity. Moreover, the impressive stability of R-LCTFe/Ni under alkaline conditions underscores its potential for practical water electrolysis applications. The superior bifunctional electrocatalytic performance can be attributed to the reduced charge transfer resistance and the synergistic cooperation between exsolved Fe nanoparticles and electrodeposited Ni compounds. The successful development of the R-LCTFe/Co catalyst further confirms the transferability of the double E strategy. Compared to R-LCTFe/Ni, the overpotential of R-LCTFe/Co is 58 mV higher for OER, yet 48 mV lower for HER at a current density of 10 mA cm −2 . This study provides an efficient and promising approach for the fabrication of highly active perovskite-based electrocatalysts, contributing valuable insights into the design of bifunctional electrocatalysts for OER and HER.}, archive = {J_ADVS}, author = {Shangshang Zuo and Chenchen Wang and Zhi Xia and Jiaxin Ding and Aaron B. Naden and John T. S. Irvine}, doi = {10.1002/advs.202410535}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410535}, shortjournal = {Adv. Sci.}, title = {Combined exsolution and electrodeposition strategy for enhancing electrocatalytic activity of ti-based perovskite oxides in oxygen and hydrogen evolution reactions}, volume = {12}, year = {2025}, }
• (2025). Dipeptidyl peptidase 4 (DPP4) exacerbates osteoarthritis progression in an enzyme-independent manner. ADVS, 12(6), 2410525. (www)

  @article{ , abstract = {Chondrocyte senescence is a key driver of osteoarthritis (OA). Mitochondrial dysfunction and oxidative stress can induce chondrocyte senescence. However, the specific mechanisms by which senescence contributes to OA progression are not fully understood. Here, it is attested that Dipeptidyl peptidase 4 (DPP4) is significantly upregulated in osteoarthritic chondrocytes in both humans and mice. DPP4 promotes oxidative stress and cellular senescence in chondrocytes through excessive mitochondrial fission in an enzyme-independent manner. Intra-articular injection of adeno-associated virus 2 to upregulate DPP4 in chondrocytes promotes post-traumatic and aging-induced OA in mice in an enzyme-independent manner. Mechanistically, DPP4 competitively binds to Myosin heavy chain 9 (MYH9), interfering with its E3 ubiquitin ligase Carboxyl terminus of Hsc70-interacting protein (CHIP), and thereby upregulates MYH9 expression. Finally, a small molecule, 4,5-Dicaffeoylquinic acid is identified, which disrupts the interaction between DPP4 and MYH9, thereby ameliorating post-traumatic and aging-induced OA in mice caused by DPP4 upregulation. The study indicates that the non-enzymatic activity of DPP4 is a promising target for OA treatment.}, archive = {J_ADVS}, author = {Xinyu Li and Zhao Zhang and Wenyu Jiang and Yucan Ju and Weihua Guo and Zeyu Huang}, doi = {10.1002/advs.202410525}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410525}, shortjournal = {Adv. Sci.}, title = {Dipeptidyl peptidase 4 (DPP4) exacerbates osteoarthritis progression in an enzyme-independent manner}, volume = {12}, year = {2025}, }
• (2025). Ternary logic transistors using multi-stacked 2D electron gas channels in ultrathin oxide heterostructures. ADVS, 12(6), 2410519. (www)

  @article{ , abstract = {2D electron gas field-effect transistors (2DEG-FETs), employing 2DEG formed at an interface of ultrathin (≈6 nm) Al 2 O 3 /ZnO heterostructure as the active channel, exhibit outstanding drive current (≈215 µA), subthreshold swing (≈132 mV dec −1 ), and field effect mobility (≈49.6 cm 2 V −1 s −1 ) with a high on/off current ratio of ≈10 7 . It is demonstrated that the Al 2 O 3 upper layer in Al 2 O 3 /ZnO heterostructure acts as the source/drain resistance component during transistor operations, and the applied potential to the 2DEG channel is successfully modulated by Al 2 O 3 thickness variations so that the threshold voltage (V th ) is effectively tuned. Remarkably, double-stacked 2DEG-FETs consisting of two Al 2 O 3 /ZnO heterostructured 2DEG channels with a single gate exhibit multiple V th , enabling a ternary logic state in a single device. By inducing a voltage difference between the stacked channels, a sequential operation of the upper and lower FETs is achieved, successfully realizing a stable ternary logic operation.}, archive = {J_ADVS}, author = {Ji Hyeon Choi and Tae Jun Seok and Sang June Kim and Kyun Seong Dae and Jae Hyuck Jang and Deok-Yong Cho and Sang Woon Lee and Tae Joo Park}, doi = {10.1002/advs.202410519}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410519}, shortjournal = {Adv. Sci.}, title = {Ternary logic transistors using multi-stacked 2D electron gas channels in ultrathin oxide heterostructures}, volume = {12}, year = {2025}, }
• (2025). Arginine-loaded nano-calcium-phosphate-stabilized lipiodol pickering emulsions potentiates transarterial embolization-immunotherapy. ADVS, 12(6), 2410484. (www)

  @article{ , abstract = {Transarterial chemoembolization (TACE) continues to stand as a primary option for treating unresectable hepatocellular carcinoma (HCC). However, the increased tumor hypoxia and acidification will lead to the immunosuppressive tumor microenvironment (TME) featuring exhausted T cells, limiting the effectiveness of subsequent therapies following TACE. Herein, a stable water-in-oil lipiodol Pickering emulsion by employing calcium phosphate nanoparticles (CaP NPs) as stabilizers is developed and used to encapsulate L-arginine (L-Arg), which is known for its ability to modulate T-cell metabolism. The obtained L-Arg-loaded CaP-stabilized lipiodol Pickering emulsion (L-Arg@CaPL) with great emulsion stability can not only neutralize the tumor acidity via reaction of CaP NPs with protons but also enable the release of L-Arg, thereby synergistically promoting the reinvigoration of exhausted CD8 + T cells and effectively reversing tumor immunosuppression. As a result, TACE therapy with L-Arg@CaPL shows greatly improved therapeutic responses as demonstrated in an orthotopic liver tumor model in rats. This study highlights an effective yet simple nanoparticle-stabilized Pickering emulsion strategy to promote TACE therapy via modulation of the immunosuppressive TME, presenting great potential for clinical translation.}, archive = {J_ADVS}, author = {Duo Wang and Lei Zhang and Wei-Hao Yang and Lin-Zhu Zhang and Chao Yu and Juan Qin and Liang-Zhu Feng and Zhuang Liu and Gao-Jun Teng}, doi = {10.1002/advs.202410484}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410484}, shortjournal = {Adv. Sci.}, title = {Arginine-loaded nano-calcium-phosphate-stabilized lipiodol pickering emulsions potentiates transarterial embolization-immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Microglia-derived vitamin d binding protein mediates synaptic damage and induces depression by binding to the neuronal receptor megalin. ADVS, 12(6), 2410273. (www)

  @article{ , abstract = {Vitamin D binding protein (VDBP) is a potential biomarker of major depressive disorder (MDD). This study demonstrates for the first time that VDBP is highly expressed in core emotion-related brain regions of mice susceptible to chronic unpredictable mild stress (CUMS). Specifically, the overexpression of microglia (MG)-derived VDBP in the prelimbic leads to depression-like behavior and aggravates CUMS-induced depressive phenotypes in mice, whereas conditional knockout of MG-derived VDBP can reverse both neuronal damage and depression-like behaviors. Mechanistically, the binding of MG-derived VDBP with the neuronal receptor megalin mediates the downstream SRC signaling pathway, leading to neuronal and synaptic damage and depression-like behaviors. These events may be caused by biased activation of inhibitory neurons and excitatory–inhibitory imbalance. Importantly, this study has effectively identified MG-derived VDBP as a pivotal mediator in the interplay between microglia and neurons via its interaction with the neuronal receptor megalin and intricate downstream impacts on neuronal functions, thus offering a promising therapeutic target for MDD.}, archive = {J_ADVS}, author = {Yan Kong and Xian Zhang and Ling Li and Te Zhao and Zihan Huang and Aini Zhang and Yun Sun and Jiao Jiao and Gaojia Zhang and Mengyu Liu and Yijun Han and Linfeng Yang and Zhijun Zhang}, doi = {10.1002/advs.202410273}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410273}, shortjournal = {Adv. Sci.}, title = {Microglia-derived vitamin d binding protein mediates synaptic damage and induces depression by binding to the neuronal receptor megalin}, volume = {12}, year = {2025}, }
• (2025). Printing untethered self-reconfigurable, self-amputating soft robots from recyclable self-healing fibers. ADVS, 12(6), 2410167. (www)

  @article{ , abstract = {Regarding the challenge of self-reconfiguration and self-amputation of soft robots, existing studies mainly focus on modular soft robots and connection methods between modules. Different from these studies, this study focus on the behavior of individual soft robots from a material perspective. Here, a kind of soft fibers, which consist of hot melt adhesive particles, magnetizable microparticles, and ferroferric oxide microparticles embedded in a thermoplastic polyurethane matrix are proposed. The soft fibers can achieve wireless self-healing and reversible bonding of the fibers by eddy current heating and can be actuated by magnetic fields. Moreover, the soft fibers are recyclable and printable. Building on this material foundation, an integrated material-structure-actuation printing strategy using soft fibers for the design and fabrication of soft robots are reported. The robots printed by this strategy can achieve their untethered motions and wireless self-healing. Soft gripper, soft crawling robot, and soft multi-legged robot, are then fabricated which demonstrates the self-healing, self-reconfigurable, self-amputating, and sustainable performances of soft robots so as to adapt to different environments and tasks. This integrated material-structure-actuation printing strategy using soft fibers is universal, easy to implement, and mass-manufactured, opening a door for sustainable, eco-friendly, untethered, self-reconfigurable, self-amputating soft robots.}, archive = {J_ADVS}, author = {Yidan Gao and Wei Tang and Yiding Zhong and Xinyu Guo and Kecheng Qin and Yonghao Wang and Elena Yu. Kramarenko and Jun Zou}, doi = {10.1002/advs.202410167}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410167}, shortjournal = {Adv. Sci.}, title = {Printing untethered self-reconfigurable, self-amputating soft robots from recyclable self-healing fibers}, volume = {12}, year = {2025}, }
• (2025). Reversing persistent PTEN activation after traumatic brain injury fuels long-term axonal regeneration via Akt/mTORC1 signaling cascade. ADVS, 12(6), 2410136. (www)

  @article{ , abstract = {Traumatic brain injury (TBI) often leads to enduring axonal damage and persistent neurological deficits. While PTEN's role in neuronal growth is recognized, its long-term activation changes post-TBI and its effects on sensory-motor circuits are not well understood. Here, it is demonstrated that the neuronal knockout of PTEN (PTEN-nKO) significantly enhances both structural and functional recovery over the long term after TBI. Importantly, in vivo, DTI-MRI revealed that PTEN-nKO promotes white matter repair post-TBI. Additionally, calcium imaging and electromyographic recordings indicated that PTEN-nKO facilitates cortical remapping and restores sensory-motor pathways. Mechanistically, PTEN negatively regulates the Akt/mTOR pathway by inhibiting Akt, thereby suppressing mTOR. Raptor is a key component of mTORC1 and its suppression impedes axonal regeneration. The restoration of white matter integrity and the improvements in neural function observed in PTEN-nKO TBI-treated mice are reversed by a PTEN/Raptor double knockout (PTEN/Raptor D-nKO), suggesting that mTORC1 acts as a key mediator. These findings highlight persistent alterations in the PTEN/Akt/mTORC1 axis are critical for neural circuit remodeling and cortical remapping post-TBI, offering new insights into TBI pathophysiology and potential therapeutic targets.}, archive = {J_ADVS}, author = {Ziyu Shi and Leilei Mao and Shuning Chen and Zhuoying Du and Jiakun Xiang and Minghong Shi and Yana Wang and Yuqing Wang and Xingdong Chen and Zhi-Xiang Xu and Yanqin Gao}, doi = {10.1002/advs.202410136}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410136}, shortjournal = {Adv. Sci.}, title = {Reversing persistent PTEN activation after traumatic brain injury fuels long-term axonal regeneration via Akt/mTORC1 signaling cascade}, volume = {12}, year = {2025}, }
• (2025). Engineered mesenchymal stem cell-derived extracellular vesicles scavenge self-antigens for psoriasis therapy via modulating metabolic and immunological disorders. ADVS, 12(6), 2410067. (www)

  @article{ , abstract = {Psoriasis is a chronic inflammatory dermatosis driven by excessive activation of the immune system. Recent studies have demonstrated the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) to psoriasis because of their immunomodulation functions. Yet, the outcome of MSC-EVs alone is still unsatisfactory and the underlying mechanisms are also unclear. Here, it is uncovered that arginase1 (Arg1)/polyamine is overexpressed in psoriasis patients and murine, inducing the in-situ accumulation of self-antigens. Engineered nor@MSC-EVs are fabricated by loading Arg1 inhibitor nor-NOHA into MSC-EVs for studying the therapeutic effect and mechanism of psoriasis. The nor@MSC-EVs exhibited profound suppression of the NF-κB signaling pathway by targeting Arg1/polyamine-mediated DCs/Th17 axis through scavenging self-antigens, resulting in superior mitigation of skin lesions and modulation of local and systemic metabolic and immunological disorders compared to the MSC-EVs and clinically used anti-IL17A both in vitro and in vivo. Together, the results highlight a novel perspective for psoriasis therapy by nor@MSC-EVs with broad clinical translational potential.}, archive = {J_ADVS}, author = {Xin Zhou and Bo Tang and Qing Huang and Siyu Yang and Yang Jiang and Lizhou Xu and Wen Chen and Guangchang Shan and Xuankai Liao and Chongchao Hou and Zhihong Yao and Chaowei Zou and Rongying Ou and Yunsheng Xu and Danyang Li}, doi = {10.1002/advs.202410067}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410067}, shortjournal = {Adv. Sci.}, title = {Engineered mesenchymal stem cell-derived extracellular vesicles scavenge self-antigens for psoriasis therapy via modulating metabolic and immunological disorders}, volume = {12}, year = {2025}, }
• (2025). Identification of CSPG4 as a biomarker and therapeutic target for infantile post-hemorrhagic hydrocephalus via multi-omics analysis. ADVS, 12(6), 2410056. (www)

  @article{ , abstract = {Intraventricular hemorrhage in preterm neonates has become a major global health problem and is associated with a high risk of post-hemorrhagic hydrocephalus (PHH). Identifying diagnostic markers and therapeutic targets is a focal challenge in the PHH prevention and control. Here, this study applies multi-omics analyses to characterize the biochemical, proteomic, and metabolomic profiles of the cerebrospinal fluid (CSF) in clinical human cohorts to investigate disease development and recovery processes occurring due to PHH. Integrative multiomics analysis suggests that the over-representation of ferroptosis, calcium, calcium ion binding, and cell adhesion signaling pathways is associated with PHH. Bioinformatic analysis indicates that chondroitin sulfate proteoglycan 4 (CSPG4) is discovered as a CSF biomarker and positively correlated with the ventricular size and the rate of periventricular leukomalacia. Next, it is further demonstrated that these signaling pathways are dysregulated in the choroid plexus (ChP) in PHH by using in vitro cellular experiments and rat models of PHH, whereas CSPG4 silencing can suppress ferroptosis, cell adhesion function, and the intracellular flow of Ca 2+ . These findings broaden the understanding of the pathophysiological mechanisms of PHH and suggest that CSPG4 may be an effective therapeutic target for PHH.}, archive = {J_ADVS}, author = {Juncao Chen and Lin Wang and Xiangwen Peng and Tingting Cheng and Yihui Yang and Jingzhen Su and Hongmei Zou and Siyao Wang and Yueting Mao and Lixiang Wu and Xuntao Yin and Minxu Li and Mingwei Zhu and Wei Zhou}, doi = {10.1002/advs.202410056}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2410056}, shortjournal = {Adv. Sci.}, title = {Identification of CSPG4 as a biomarker and therapeutic target for infantile post-hemorrhagic hydrocephalus via multi-omics analysis}, volume = {12}, year = {2025}, }
• (2025). An integrated whole-process repair system with programmed regulation of healing performance facilitates urethral wound restoration and scarless reconstruction. ADVS, 12(6), 2409930. (www)

  @article{ , abstract = {The harsh microenvironment of the urethral injury often carries high risks of early undesirable healing as well as late scar tissue formation. Indeed, the infection and inflammatory response in the early stages as well as blood vessel formation and tissue regeneration in the later stages fundamentally impact the outcomes of urethral wound healing. Innovatively, an integrated whole-process repair hydrogel (APF/C/L@dECM) is designed. After rigorous testing, it is found that hydrogels formed by hydrophobic association and double cross-linking of amide bonds can procedurally regulate wound healing in all phases to match the repair process. In rabbit models of urethral wound, APF/C/L@dECM hydrogel can achieve scarless reconstruction with significantly better results than other hydrogels. Noteworthily, multi-stage mechanistic explorations reveal the expression profiles of inflammation, vascularization, and extracellular matrix secretion-related genes in wound tissue at different times. In summary, this study develops an overall treatment for urethral injury through a whole-process repair system that promotes healthy healing of urethral wounds and prevents the formation of scar tissue.}, archive = {J_ADVS}, author = {Wenzhuo Fang and Ying Wang and Kaile Zhang and Ming Yang and Meng Liu and Yangwang Jin and Xianjie Xiu and Yuhui Wang and Zhenwei Yu and Ranxing Yang and Qiang Fu}, doi = {10.1002/advs.202409930}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2409930}, shortjournal = {Adv. Sci.}, title = {An integrated whole-process repair system with programmed regulation of healing performance facilitates urethral wound restoration and scarless reconstruction}, volume = {12}, year = {2025}, }
• (2025). Dietary palmitic acid drives a palmitoyltransferase ZDHHC15-YAP feedback loop promoting tumor metastasis. ADVS, 12(6), 2409883. (www)

  @article{ , abstract = {Elevated uptake of saturated fatty acid palmitic acid (PA) is associated with tumor metastasis; however, the precise mechanisms remain partially understood, hindering the development of therapy for PA-driven tumor metastasis. The Hippo–Yes-associated protein (Hippo/YAP) pathway is implicated in cancer progression. Here it is shown that a high-palm oil diet potentiates tumor metastasis in murine xenografts in part through YAP. It is found that the palmitoyltransferase ZDHHC15 is a YAP-regulated gene that forms a feedback loop with YAP. Notably, PA drives the ZDHHC15-YAP feedback loop, thus enforces YAP signaling, and hence promotes tumor metastasis in murine xenografts. In addition, it is shown that ZDHHC15 associates with Kidney and brain protein (KIBRA, also known as WW- and C2 domain-containing protein 1, WWC1), an upstream component of Hippo signaling, and mediates its palmitoylation. KIBRA palmitoylation leads to its degradation and regulates its subcellular localization and activity toward the Hippo/YAP pathway. Moreover, PA enhances KIBRA palmitoylation and degradation. It is further shown that combinatorial targeting of YAP and fatty acid synthesis exhibits augmented effects against metastasis formation in mice fed with a Palm diet. Collectively, these findings uncover a ZDHHC15-YAP feedback loop as a previously unrecognized mechanism underlying PA-promoted tumor metastasis and support targeting YAP and fatty acid synthesis as potential therapeutic targets in PA-driven tumor metastasis.}, archive = {J_ADVS}, author = {Jianxin Wang and Dachuan Shen and Jian Jiang and Lulu Hu and Kun Fang and Chunrui Xie and Ning Shen and Yuzhao Zhou and Yifei Wang and Sha Du and Songshu Meng}, doi = {10.1002/advs.202409883}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2409883}, shortjournal = {Adv. Sci.}, title = {Dietary palmitic acid drives a palmitoyltransferase ZDHHC15-YAP feedback loop promoting tumor metastasis}, volume = {12}, year = {2025}, }
• (2025). Microfluidic electrospinning Core–Shell nanofibers for anti-corrosion coatings with efficient self-healing properties. ADVS, 12(6), 2409751. (www)

  @article{ , abstract = {Self-healing materials have been extensively explored in metal anti-corrosion fields. However, improving the self-healing efficiency remains a significant work that severely limits their further development. Here, a strategy to fabricate anti-corrosion coatings with efficient self-healing properties based on microfluidic electrospinning technologies and UV-curable healing agents is reported. The damaged composite coating contains core–shell nanofibers that can be completely healed within only 30 min, indicating an outstanding healing efficiency. The corrosion current density ( I corr ) of the composite coatings containing core–shell nanofibers (abbreviated as composite coatings) is lower than the coatings without any fibers (abbreviated as pure resin coatings) during the test of repeated damage and healing cycles, showing superior resistance to corrosion and repeated self-healing property. The composite coating has even better mechanical properties such as tensile strength, bending strength, and impact strength than the pure resin coating, which are explained by simulating the deformation process. These excellent properties greatly improve the practicability of self-healing coatings in the application of anti-corrosion, especially in some special fields.}, archive = {J_ADVS}, author = {Qingqing Tang and Cuiping Ji and Guoying Wei and Jing Hu and Feifan Chang and Benfeng Zhu and Li Ren and Dongliang Peng}, doi = {10.1002/advs.202409751}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2409751}, shortjournal = {Adv. Sci.}, title = {Microfluidic electrospinning Core–Shell nanofibers for anti-corrosion coatings with efficient self-healing properties}, volume = {12}, year = {2025}, }
• (2025). Artificial photothermal nociceptor using mott oscillators. ADVS, 12(6), 2409353. (www)

  @article{ , abstract = {Bioinspired sensory systems based on spike neural networks have received considerable attention in resolving high energy consumption and limited bandwidth in current sensory systems. To efficiently produce spike signals upon exposure to external stimuli, compact neuron devices are required for signal detection and their encoding into spikes in a single device. Herein, it is demonstrated that Mott oscillative spike neurons can integrate sensing and ceaseless spike generation in a compact form, which emulates the process of evoking photothermal sensing in the features of biological photothermal nociceptors. Interestingly, frequency-tunable and repetitive spikes are generated above the threshold value ( P th = 84 mW cm −2 ) as a characteristic of “threshold” in leaky-integrate-and-fire (LIF) neurons; the neuron devices successfully mimic a crucial feature of biological thermal nociceptors, including modulation of frequency coding and startup latency depending on the intensity of photothermal stimuli. Furthermore, Mott spike neurons are self-adapted after sensitization upon exposure to high-intensity electromagnetic radiation, which can replicate allodynia and hyperalgesia in a biological sensory system. Thus, this study presents a unique approach to capturing and encoding environmental source data into spikes, enabling efficient sensing of environmental sources for the application of adaptive sensory systems.}, archive = {J_ADVS}, author = {Pyeongkang Hur and Daseob Yoon and Minwook Yoon and Yunkyu Park and Junwoo Son}, doi = {10.1002/advs.202409353}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2409353}, shortjournal = {Adv. Sci.}, title = {Artificial photothermal nociceptor using mott oscillators}, volume = {12}, year = {2025}, }
• (2025). Tubulin-based microtentacles aid in heterotypic clustering of neutrophil-differentiated HL-60 cells and breast tumor cells. ADVS, 12(6), 2409260. (www)

  @article{ , abstract = {Circulating tumor cells (CTCs) travel through the vasculature to seed secondary sites and serve as direct precursors of metastatic outgrowth for many solid tumors. Heterotypic cell clusters form between CTCs and white blood cells (WBCs) and recent studies report that a majority of these WBCs are neutrophils in patient and mouse models. The lab discovered that CTCs produce tubulin-based protrusions, microtentacles (McTNs), which promote reattachment, retention in distant sites during metastasis and formation of tumor cell clusters. Neutrophil-CTC clusters help CTCs survive the harsh vascular environment to promote successful metastasis, however, the specific mechanism of this interaction is not fully understood. Utilizing TetherChip technology, it is found that primary and differentiated neutrophils produce McTNs composed of detyrosinated and acetylated α-tubulin and vimentin. Neutrophil McTNs aid in cluster formation, migration, and reattachment, which are suppressed with the tubulin-depolymerizing agent, Vinorelbine. Co-culturing differentiated neutrophils and tumor cells formed heterotypic clusters that enhanced migration. CTC-neutrophil clusters have higher metastatic efficiency, and by demonstrating that neutrophils form McTNs, a new possible mechanism for how neutrophils interact with tumor cells is revealed. These findings further support the idea that developing cluster-disrupting therapies can provide a new targeted strategy to reduce the metastatic potential of cancer cells.}, archive = {J_ADVS}, author = {Julia A. Ju and Keyata N. Thompson and David A. Annis and Makenzy L. Mull and Darin E. Gilchrist and Aidan Moriarty and Katarina T. Chang and Megan B. Stemberger and Michael J. Noto and Michele I. Vitolo and Stuart S. Martin}, doi = {10.1002/advs.202409260}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2409260}, shortjournal = {Adv. Sci.}, title = {Tubulin-based microtentacles aid in heterotypic clustering of neutrophil-differentiated HL-60 cells and breast tumor cells}, volume = {12}, year = {2025}, }
• (2025). TTK inhibition alleviates postinjury neointimal formation and atherosclerosis. ADVS, 12(6), 2409250. (www)

  @article{ , abstract = {Atherosclerosis and its associated cardio-cerebrovascular complications remain the leading causes of mortality worldwide. Current lipid-lowering therapies reduce only approximately one-third of the cardiovascular risk. Furthermore, vascular restenosis and thrombotic events following surgical interventions for severe vascular stenosis significantly contribute to treatment failure. This highlights the urgent need for novel therapeutic targets to manage atherosclerosis and prevent restenosis and thrombosis after vascular injury. This study identifies TTK protein kinase (TTK) as a key regulator of vascular smooth muscle cell (VSMC) phenotypic switching in the context of postinjury neointimal formation and atherosclerosis. Mechanistically, TTK upregulation in VSMCs phosphorylates p120-catenin, leading to β-catenin nuclear accumulation and dissociation of the myocardin (MYOCD)/serum response factor (SRF) complex. Deletion of TTK specifically in VSMCs reduces postinjury neointimal formation in vascular injury models and attenuates atherosclerotic lesions in ApoE −/− mice. Notably, oral administration of the TTK inhibitor CFI-402257 mitigated neointimal formation without impairing reendothelialization and reduced atherosclerotic lesions in ApoE −/− mice without altering lipid levels. These findings suggest that targeting TTK, through inhibitors or alternative strategies, represents a promising approach to simultaneously prevent postinjury restenosis and treat atherosclerosis.}, archive = {J_ADVS}, author = {Jie-Hong Wu and Yu-Xiao Liu and Jia-Bin Zong and Min Qiu and Yi-Fan Zhou and Ya-Nan Li and Tuersun Aili and Xin-Ran Zhao and Bo Hu}, doi = {10.1002/advs.202409250}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2409250}, shortjournal = {Adv. Sci.}, title = {TTK inhibition alleviates postinjury neointimal formation and atherosclerosis}, volume = {12}, year = {2025}, }
• (2025). The Na+,K+,2Cl− cotransporter, not aquaporin 1, sustains cerebrospinal fluid secretion while controlling brain k+ homeostasis. ADVS, 12(6), 2409120. (www)

  @article{ , abstract = {Disturbances in the brain fluid balance can lead to life-threatening elevation in intracranial pressure (ICP), which represents a vast clinical challenge. Targeted and efficient pharmaceutical therapy of elevated ICP is not currently available, as the molecular mechanisms governing cerebrospinal fluid (CSF) secretion are largely unresolved. To resolve the quantitative contribution of key choroid plexus transport proteins, this study employs mice with genetic knockout and/or viral choroid plexus-specific knockdown of aquaporin 1 (AQP1) and the Na + , K + , 2Cl − cotransporter 1 (NKCC1) for in vivo determinations of CSF dynamics, ex vivo choroid plexus for transporter-mediated clearance of a CSF K + load, and patient CSF for [K + ] quantification. CSF secretion and ICP management occur independently of choroid plexus AQP1 expression, whereas both parameters are reduced by 40% upon choroid plexus NKCC1 knockdown. Elevation of [K + ] CSF increases the choroid plexus Na + /K + -ATPase activity, and favors inwardly-directed net NKCC1 transport, which, together, promote CSF K + clearance, while maintaining undisturbed CSF secretion rates. CSF from patients with post-hemorrhagic hydrocephalus does not display elevated [K + ] CSF , suggesting that NKCC1 maintains net outward transport direction during post-hemorrhagic hydrocephalus formation. Direct or indirect therapeutic modulation of choroid plexus NKCC1 can thus be a potential promising pharmacological approach against brain pathologies associated with elevated ICP.}, archive = {J_ADVS}, author = {Dennis Bo Jensen and Trine L. Toft-Bertelsen and Dagne Barbuskaite and Jane Stubbe and Sandor Nietzsche and Tenna Capion and Nicolas H. Norager and Markus H. Olsen and Andreas T. Sørensen and Henrik Dimke and Christian A. Hübner and Marianne Juhler and Nanna MacAulay}, doi = {10.1002/advs.202409120}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2409120}, shortjournal = {Adv. Sci.}, title = {The Na+,K+,2Cl− cotransporter, not aquaporin 1, sustains cerebrospinal fluid secretion while controlling brain k+ homeostasis}, volume = {12}, year = {2025}, }
• (2025). Citrate-coated iron oxide nanoparticles facilitate endothelialization of left ventricular assist device impeller for improved antithrombogenicity. ADVS, 12(6), 2408976. (www)

  @article{ , abstract = {Although left ventricular assist devices (LVADs) are an alternative to heart transplantation, their artificial surfaces often lead to serious thrombotic complications requiring high-risk device replacement. Coating blood-contacting surfaces with antithrombogenic endothelial cells is considered an effective strategy for preventing thrombus formation. However, this concept has not yet been successfully implemented in LVADs, as severe cell loss is to be expected, especially on the impeller surface with high prothrombogenic supraphysiological shear stress. This study presents a strategy that exploits the magnetic attraction of the impeller on ECs loaded with iron oxide nanoparticles (IONPs) to minimize shear stress-induced cell detachment from the rotating magnetic impeller while ensuring antithrombogenic EC adhesion, especially as a bridge until they formed their adhesion-promoting matrix. In contrast to polyvinylpyrrolidone (PVP)-coated IONPs, more efficient and safer cell loading is achieved with sodium citrate (Cit)-stabilized IONPs, where incubation with 6.6 µg iron mL-1 Cit-IONPs for 24 h resulting in an average internalization of 23 pg iron per cell. Internalization of Cit-IONP significantly improved cell attraction to the highly magnetic impeller surface without affecting cell viability or antithrombogenic function. This protocol is key for the development of a biohybrid LVAD impeller that can prevent life-threatening thrombosis and hemorrhage in a future clinical application.}, archive = {J_ADVS}, author = {Jasper L. Haritz and Michael Pflaum and Hans J. Güntner and Katherina Katsirntaki and Jan Hegermann and Felix Hehnen and Michael Lommel and Ulrich Kertzscher and Jutta Arens and Axel Haverich and Arjang Ruhparwar and Bettina Wiegmann}, doi = {10.1002/advs.202408976}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408976}, shortjournal = {Adv. Sci.}, title = {Citrate-coated iron oxide nanoparticles facilitate endothelialization of left ventricular assist device impeller for improved antithrombogenicity}, volume = {12}, year = {2025}, }
• (2025). Capture of totipotency in mouse embryonic stem cells in the absence of pdzk1. ADVS, 12(6), 2408852. (www)

  @article{ , abstract = {Totipotent cells can differentiate into three lineages: the epiblast, primitive endoderm, and trophectoderm. Naturally, only early fertilized embryos possess totipotency, and they lose this ability as they develop. The expansion of stem cell differentiation potential has been a hot topic in developmental biology for years, particularly with respect to the generation totipotent-like stem cells. Here, the study describes the establishment of totipotency in embryonic stem cells (ESCs) via the deletion of a single gene, Pdzk1 . Pdzk1 -knockout (KO) ESCs substantially contribute to the fetus, placenta, and yolk sac in chimera assays but can also self-organize to form standard blastocyst-like structures containing the three lineages efficiently; thus, they exhibit full developmental potential as early blastomeres. Single-cell transcriptome and bulk RNA-seq comprehensive analyses revealed that Pdzk1 -KO activates several lineage inducers ( C1qa , C1qb , Fgf5 , and Cdx2 ) to break down barriers between embryonic and extraembryonic tissues, making these lineages switch smoothly and resulting in a totipotent-like state. This versatile and scalable system provides a robust experimental model for differentiation potency and cell fate studies.}, archive = {J_ADVS}, author = {Wenhao Zhang and Yiding Zhao and Zhe Yang and Jing Yan and Haisong Wang and Shaochen Nie and Qingshen Jia and Dan Ding and Chao Tong and Xiao-Ou Zhang and Qian Gao and Ling Shuai}, doi = {10.1002/advs.202408852}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408852}, shortjournal = {Adv. Sci.}, title = {Capture of totipotency in mouse embryonic stem cells in the absence of pdzk1}, volume = {12}, year = {2025}, }
• (2025). Evaporative morphology tuning of conducting polymer films under controlled vacuum conditions. ADVS, 12(6), 2408790. (www)

  @article{ , abstract = {The evaporation of drops on solid surfaces is a ubiquitous natural phenomenon, and their dynamics play a pivotal role in many biological, environmental, and industrial processes. However, the complexity of the underlying mechanisms has largely confined previous studies to liquid drop evaporation under atmospheric conditions. In this study, the first comprehensive investigation of the evaporation dynamics of conducting polymer-containing drops under controlled vacuum environments is presented. Utilizing high-speed imaging of a drop within a vacuum chamber, it is observed that the evaporation of a sessile drop under vacuum conditions unfolds through four distinct stages: Constant Contact Radius (CCR), Constant Contact Angle (CCA), Increasing Contact Angle (ICA), and Stick and Slip (S&S) modes. The detailed analysis of the force balance reveals that the depinning dynamics of the contact line, significantly driven by vacuum-induced forces, are the primary factor distinguishing these evaporation modes. A modified diffusion-limited model specifically tailored for vacuum conditions is further developed, which closely aligns with the experimental data on volume reduction over time. Importantly, the study demonstrates that by carefully adjusting the vacuum level, it is possible to precisely manipulate the final film morphology, with uniform deposition achieved at an optimal pressure of 20 kPa. This research introduces a novel approach for controlling drop evaporation dynamics in vacuum, with potential applications in advanced manufacturing processes.}, archive = {J_ADVS}, author = {Seongju Kim and Byung Mook Weon and Dong Jin Kang and Sungjune Jung}, doi = {10.1002/advs.202408790}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408790}, shortjournal = {Adv. Sci.}, title = {Evaporative morphology tuning of conducting polymer films under controlled vacuum conditions}, volume = {12}, year = {2025}, }
• (2025). Diversified fluoroalkylation of alkenes using quaternary fluoroalkyl alcohols as the fluoroalkylating reagents. ADVS, 12(6), 2408781. (www)

  @article{ , abstract = {Given the widespread presence of fluoroalkyl functionalities in bioactive molecules, the development of fluoroalkylation reactions with bench-stable and easy-to-use fluoroalkylating reagents is highly desirable. In addition, realization of mono-, di-, tri-, or polyfluoroalkyation usually requires distinct types of fluoroalkylating reagents under different or even harsh reaction conditions, and a universal method to accomplish different hydrofluoroalkylation of alkenes is lacking. Herein, the use of quaternary fluoroalkyl alcohols is reported as the universal fluoroalkylating reagents to readily facilitate mono-, di-, tri-, or polyfluoroalkylation of a wide range of alkene substrates in high yields. Moreover, a cascade reaction of hydrofluoroalkylation followed by intramolecular fluoroalkylation facilitates the construction of a variety of high-value complex heterocycles bearing diverse fluoroalkyl functionalities from alkenes. Mechanistic studies suggest that a proton-coupled electron transfer (PCET) process may be involved through a radical-generating pathway. The utility of this method is showcased by the late-stage fluoroalkylation of various high-value complex molecules derived from either natural products or drug-like compounds. Of note is that a continuous-flow system is amenable to this homogeneous photoredox conditions, thereby opening up a possibility of using this protocol to realize large-scale manufacturing of fluoroalkyl products with industrial interests.}, archive = {J_ADVS}, author = {Heng Lu and Zhoulong Fan and Yike Zou and Ao Zhang}, doi = {10.1002/advs.202408781}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408781}, shortjournal = {Adv. Sci.}, title = {Diversified fluoroalkylation of alkenes using quaternary fluoroalkyl alcohols as the fluoroalkylating reagents}, volume = {12}, year = {2025}, }
• (2025). Emerging wearable acoustic sensing technologies. ADVS, 12(6), 2408653. (www)

  @article{ , abstract = {Sound signals not only serve as the primary communication medium but also find application in fields such as medical diagnosis and fault detection. With public healthcare resources increasingly under pressure, and challenges faced by disabled individuals on a daily basis, solutions that facilitate low-cost private healthcare hold considerable promise. Acoustic methods have been widely studied because of their lower technical complexity compared to other medical solutions, as well as the high safety threshold of the human body to acoustic energy. Furthermore, with the recent development of artificial intelligence technology applied to speech recognition, speech recognition devices, and systems capable of assisting disabled individuals in interacting with scenes are constantly being updated. This review meticulously summarizes the sensing mechanisms, materials, structural design, and multidisciplinary applications of wearable acoustic devices applied to human health and human–computer interaction. Further, the advantages and disadvantages of the different approaches used in flexible acoustic devices in various fields are examined. Finally, the current challenges and a roadmap for future research are analyzed based on existing research progress to achieve more comprehensive and personalized healthcare.}, archive = {J_ADVS}, author = {Tao Liu and Yuchen Mao and Hanjie Dou and Wangyang Zhang and Jiaqian Yang and Pengfan Wu and Dongxiao Li and Xiaojing Mu}, doi = {10.1002/advs.202408653}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408653}, shortjournal = {Adv. Sci.}, title = {Emerging wearable acoustic sensing technologies}, volume = {12}, year = {2025}, }
• (2025). Deep learning-enabled STEM imaging for precise single-molecule identification in zeolite structures. ADVS, 12(6), 2408629. (www)

  @article{ , abstract = {Observing chemical reactions in complex structures such as zeolites involves a major challenge in precisely capturing single-molecule behavior at ultra-high spatial resolutions. To address this, a sophisticated deep learning framework tailored has been developed for integrated Differential Phase Contrast Scanning Transmission Electron Microscopy (iDPC-STEM) imaging under low-dose conditions. The framework utilizes a denoising super-resolution model (Denoising Inference Variational Autoencoder Super-Resolution (DIVAESR)) to effectively mitigate shot noise and thereby obtain substantially clearer atomic-resolved iDPC-STEM images. It supports advanced single-molecule detection and analysis, such as conformation matching and elemental clustering, by incorporating object detection and Density Functional Theory (DFT) configurational matching for precise molecular analysis. the model's performance is demonstrated with a significant improvement in standard image quality evaluation metrics including Peak Signal-to-Noise Ratio (PSNR) and Structural Similarity Index Measure (SSIM). The test conducted using synthetic datasets shows its robustness and extended applicability to real iDPC-STEM images, highlighting its potential in elucidating dynamic behaviors of single molecules in real space. This study lays a critical groundwork for the advancement of deep learning applications within electron microscopy, particularly in unraveling chemical dynamics through precise material characterization and analysis.}, archive = {J_ADVS}, author = {Yaotian Yang and Hao Xiong and Zirong Wu and Zhiyao Luo and Xiao Chen and Xiaonan Wang and Fei Wei}, doi = {10.1002/advs.202408629}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408629}, shortjournal = {Adv. Sci.}, title = {Deep learning-enabled STEM imaging for precise single-molecule identification in zeolite structures}, volume = {12}, year = {2025}, }
• (2025). Brain-computer interfaces using flexible electronics: An a-IGZO front-end for active ECoG electrodes. ADVS, 12(6), 2408576. (www)

  @article{ , abstract = {Brain-computer interfaces (BCIs) are evolving toward higher electrode count and fully implantable solutions, which require extremely low power densities (<15mW cm −2 ). To achieve this target, and allow for a large and scalable number of channels, flexible electronics can be used as a multiplexing interface. This work introduces an active analog front-end fabricated with amorphous Indium-Gallium-Zinx-Oxide (a-IGZO) Thin-Film Transistors (TFTs) on foil capable of active matrix multiplexing. The circuit achieves only 70nV per sqrt(Hz) input referred noise, consuming 46µW, or 3.5mW cm −2 . It demonstrates for the first time in literature a flexible front-end with a noise efficiency factor comparable with Silicon solutions (NEF = 9.8), which is more than 10X lower compared to previously reported flexible front-ends. These results have been achieved using a modified bootstrap-load amplifier. The front end is tested by playing through it recordings obtained from a conventional BCI system. A gesture classification based on the flexible front-end outputs achieves 94% accuracy. Using a flexible active front end can improve the state-of-the-art in high channel count BCI systems by lowering the multiplexer noise and enabling larger areas of the brain to be monitored while reducing power density. Therefore, this work enables a new generation of high channel-count active BCI electrode grids.}, archive = {J_ADVS}, author = {Kyle van Oosterhout and Ashley Chilundo and Mariana P. Branco and Erik J. Aarnoutse and Martijn Timmermans and Marco Fattori and Nick F. Ramsey and Eugenio Cantatore}, doi = {10.1002/advs.202408576}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408576}, shortjournal = {Adv. Sci.}, title = {Brain-computer interfaces using flexible electronics: An a-IGZO front-end for active ECoG electrodes}, volume = {12}, year = {2025}, }
• (2025). Halbach array induced magnetic field alignment in boron nitride nanocomposites. ADVS, 12(6), 2408532. (www)

  @article{ , abstract = {Thermal conductivity enhancement in polymers is vital for advanced applications. This study introduces a novel method to align hexagonal boron nitride (hBN) nanosheets within polydimethylsiloxane (PDMS) matrices using a Halbach array to create a highly uniform magnetic field. This technique achieves significant improvements in thermal conductivity by effectively aligning hBN nanosheets. This research shows that hBN nanosheets, when aligned, can drastically enhance thermal conductivity in PDMS composites. Specifically, 10 wt.% vertically aligned hBN nanosheets in a rotating magnetic field achieve a thermal conductivity of 3.58 W mK −1 , an impressive 1950% increase over pure PDMS. Additionally, the study explores the effects of orientation on dielectric properties, finding that the orientation of hBN nanosheets also improves electrical insulation and increases the dielectric constant while maintaining extremely low dielectric losses. For a vertically oriented sample, the dielectric constant reaches ≈14, and dielectric losses are as low as 0.0049 at 100 Hz, highlighting their potential for energy storage capacitors. This approach not only enhances thermal management but also maintains or improves electrical insulation, offering promising advances for polymer composites in various technological applications.}, archive = {J_ADVS}, author = {Viney Ghai and Ases Akas Mishra and Enling Huang and Roselle Ngaloy and Saroj P. Dash and Aleksandar Matic and Roland Kádár}, doi = {10.1002/advs.202408532}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408532}, shortjournal = {Adv. Sci.}, title = {Halbach array induced magnetic field alignment in boron nitride nanocomposites}, volume = {12}, year = {2025}, }
• (2025). Biomaterials for corneal regeneration. ADVS, 12(6), 2408021. (www)

  @article{ , abstract = {Corneal blindness is a significant reason for visual impairment globally. Researchers have been investigating several methods for corneal regeneration in order to cure these patients. Biomaterials are favored due to their biocompatibility and capacity to promote cell adhesion. A variety of natural and synthetic biomaterials, along with decellularized cornea, have been employed in corneal wound healing. Commonly utilized natural biomaterials encompass proteins such as collagen, gelatin, and silk fibroin (SF), as well as polysaccharides including alginate, chitosan (CS), hyaluronic acid (HA), and cellulose. Synthetic biomaterials primarily consist of polyvinyl alcohol (PVA), poly(ε-caprolactone) (PCL), and poly (lactic-co-glycolic acid) (PLGA). Bio-based materials and their composites are primarily utilized as hydrogels, films, scaffolds, patches, nanocapsules, and other formats for the treatment of blinding ocular conditions, including corneal wounds, corneal ulcers, corneal endothelium, and stromal defects. This review attempts to summarize in vitro, preclinical, and clinical trial studies relevant to corneal regeneration using biomaterials within the last five years, and expect that these experiences and outcomes will inspire and provide practical strategies for the future development of biomaterials for corneal regeneration. Furthermore, potential improvements and difficulties for these biomaterials are discussed.}, archive = {J_ADVS}, author = {Yimeng Li and Zhengke Wang}, doi = {10.1002/advs.202408021}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2408021}, shortjournal = {Adv. Sci.}, title = {Biomaterials for corneal regeneration}, volume = {12}, year = {2025}, }
• (2025). Efficient photolysis of multidrug-resistant polymicrobial biofilms. ADVS, 12(6), 2407898. (www)

  @article{ , abstract = {Chronic wounds are prone to infections with multidrug-resistant bacteria, forming polymicrobial biofilms that limit treatment options and increase the risk of severe complications. Current cleansing options are insufficient to disrupt and remove tenacious biofilms; antibiotic treatments, on the other hand, often fall short against these biofilm-embedded bacteria. This study explores an non-antibiotic approach that extends beyond conventional porphyrin-based phototherapy by using blue light (BL) in conjunction with ferric ions (Fe(III)) to disrupt and eradicate biofilms. The dual not only degraded biofilm extracellular polymeric substances (EPS) in mono-species and polymicrobial biofilms by specifically targeting carboxyl-containing polysaccharides within the matrix but also exhibited broad-spectrum antimicrobial activity by affecting key components of the outer membrane and cell wall. Bacteria, such as K. pneumoniae , with compromised EPS after photolysis, demonstrated increased susceptibility to macrophage phagocytosis. Disruption of the polymicrobial biofilm structure also enhanced the bacterial susceptibility to bactericidal drugs. Treating wounds infected by mixed-species biofilm in diabetic mice demonstrated a substantial reduction in bacterial colonization and improved tissue repair. The BL-Fe(III) modality offers a safe, efficient alternative for managing chronic wound infections, making it ideal for repeated, non-invasive use at home, especially in resource-limited areas.}, archive = {J_ADVS}, author = {Yongli Li and Yan Dong and ZhengKun Zhang and Zuan-tao Lin and Chen Liang and Mei X. Wu}, doi = {10.1002/advs.202407898}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2407898}, shortjournal = {Adv. Sci.}, title = {Efficient photolysis of multidrug-resistant polymicrobial biofilms}, volume = {12}, year = {2025}, }
• (2025). Triboelectric mat multimodal sensing system (TMMSS) enhanced by infrared image perception for sleep and emotion-relevant activity monitoring. ADVS, 12(6), 2407888. (www)

  @article{ , abstract = {To implement digital-twin smart home applications, the mat sensing system based on triboelectric sensors is commonly used for gait information collection from daily activities. Yet traditional mat sensing systems often miss upper body motions and fail to adequately project these into the virtual realm, limiting their specific application scenarios. Herein, triboelectric mat multimodal sensing system is designed, enhanced with a commercial infrared imaging sensor, to capture diverse sensory information for sleep and emotion-relevant activity monitoring without compromising privacy. This system generates pixel-based area ratio mappings across the entire mat array, solely based on the integral operation of triboelectric outputs. Additionally, it utilizes multimodal sensory intelligence and deep-learning analytics to detect different sleeping postures and monitor comprehensive sleep behaviors and emotional states associated with daily activities. These behaviors are projected into the metaverse, enhancing virtual interactions. This multimodal sensing system, cost-effective and non-intrusive, serves as a functional interface for diverse digital-twin smart home applications such as healthcare, sports monitoring, and security.}, archive = {J_ADVS}, author = {Jinlong Xu and Xinge Guo and Zixuan Zhang and Huajun Liu and Chengkuo Lee}, doi = {10.1002/advs.202407888}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2407888}, shortjournal = {Adv. Sci.}, title = {Triboelectric mat multimodal sensing system (TMMSS) enhanced by infrared image perception for sleep and emotion-relevant activity monitoring}, volume = {12}, year = {2025}, }
• (2025). A room-temperature terahertz photodetector imaging with high stability and polarization-sensitive based on Perovskite/Metasurface. ADVS, 12(6), 2407634. (www)

  @article{ , abstract = {Terahertz (THz) polarization detection facilitates the capture of multidimensional data, including intensity, phase, and polarization state, with broad applicability in high-resolution imaging, communication, and remote sensing. However, conventional semiconductor materials are limited by energy band limitations, rendering them unsuitable for THz detection. Overcoming this challenge, the realization of high-stability, room-temperature polarization-sensitive THz photodetectors (PDs) leveraging the thermoelectric effect of Cs 0.05 (FA 0.85 MA 0.15 ) 0.95 Pb(I 0.85 Br 0.15 ) 3 (CsFAMA)/metasurfaces is presented. Two different structures of (T-shaped and I-shaped) THz PDs are constructed. The incorporation of perovskite/metasurfaces forms enhanced local field thermoelectric effect and polarization response. Owning to THz surface plasmon polariton (SPP) resonance effect and more boundary effect, the I-shaped PDs exhibit superior performance, achieving a response of up to 94 V/W, with a response time of 138 µs, a low noise-equivalent power of 5.03 pW/Hz 1/2 and an anisotropy ratio of 1.38 under 0.1THz laser irradiation. Furthermore, the PD's stability is verified with the anisotropy ratio decreased by only 2% and polarization imaging results after 240 days of storage in air condition. This research introduces a method for achieving high-performance, stable THz polarization detection technology, with significant potential for advancements in materials science, communication technology, and medical imaging.}, archive = {J_ADVS}, author = {Yifan Li and Yiming Jia and He Yang and Yinghui Wu and Yajun Cao and Xuyang Zhang and Cunguang Lou and Xiuling Liu and Long-Biao Huang and Jianquan Yao}, doi = {10.1002/advs.202407634}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2407634}, shortjournal = {Adv. Sci.}, title = {A room-temperature terahertz photodetector imaging with high stability and polarization-sensitive based on Perovskite/Metasurface}, volume = {12}, year = {2025}, }
• (2025). Structural design and challenges of micron-scale silicon-based lithium-ion batteries. ADVS, 12(6), 2407540. (www)

  @article{ , abstract = {Currently, lithium-ion batteries (LIBs) are at the forefront of energy storage technologies. Silicon-based anodes, with their high capacity and low cost, present a promising alternative to traditional graphite anodes in LIBs, offering the potential for substantial improvements in energy density. However, the significant volumetric changes that silicon-based anodes undergo during charge and discharge cycles can lead to structural degradation. Furthermore, the formation of excessive solid-electrolyte interphases (SEIs) during cycling impedes the efficient migration of ions and electrons. This comprehensive review focuses on the structural design and optimization of micron-scale silicon-based anodes from both materials and systems perspectives. Significant progress is made in the development of advanced electrolytes, binders, and conductive additives that complement micron-scale silicon-based anodes in both half and full-cells. Moreover, advancements in system-level technologies, such as pre-lithiation techniques to mitigate irreversible Li + loss, have enhanced the energy density and lifespan of micron-scale silicon-based full cells. This review concludes with a detailed classification of the underlying mechanisms, providing a comprehensive summary to guide the development of high-energy-density devices. It also offers strategic insights to address the challenges associated with the large-scale deployment of silicon-based LIBs.}, archive = {J_ADVS}, author = {Wenjie He and Wei Xu and Zhigang Li and Zhaotong Hu and Jia Yang and Gang Qin and Weiming Teng and Tengfei Zhang and Wei Zhang and Zhengming Sun and Xuebin Yu}, doi = {10.1002/advs.202407540}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2407540}, shortjournal = {Adv. Sci.}, title = {Structural design and challenges of micron-scale silicon-based lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Progress in nanotechnology for treating ocular surface chemical injuries: Reflecting on advances in ophthalmology. ADVS, 12(6), 2407340. (www)

  @article{ , abstract = {Ocular surface chemical injuries often result in permanent visual impairment and necessitate complex, long-term treatments. Immediate and extensive irrigation serves as the first-line intervention, followed by various therapeutic protocols applied throughout different stages of the condition. To optimize outcomes, conventional regimens increasingly incorporate biological agents and surgical techniques. In recent years, nanotechnology has made significant strides, revolutionizing the management of ocular surface chemical injuries by enabling sustained drug release, enhancing treatment efficacy, and minimizing side effects. This review provides a comprehensive analysis of the etiology, epidemiology, classification, and conventional therapies for ocular chemical burns, with a special focus on nanotechnology-based drug delivery systems in managing ocular surface chemical injuries. Twelve categories of nanocarrier platforms are examined, including liposomes, nanoemulsions, nanomicelles, nanowafers, nanostructured lipid carriers, nanoparticles, hydrogels, dendrimers, nanocomplexes, nanofibers, nanozymes, and nanocomposite materials, highlighting their advantages in targeted delivery, biocompatibility, and improved healing efficacy. Additionally, current challenges and limitations in the field are discussed and the future potential of nanotechnology in treating ocular diseases is explored. This review presents the most extensive examination of this topic to date, aiming to link recent advancements with broader therapeutic strategies.}, archive = {J_ADVS}, author = {Qiaoran Qi and Dai Su and Shuqin Zhuang and Sunyuan Yao and Ludwig M. Heindl and Xianqun Fan and Ming Lin and Jin Li and Yan Pang}, doi = {10.1002/advs.202407340}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2407340}, shortjournal = {Adv. Sci.}, title = {Progress in nanotechnology for treating ocular surface chemical injuries: Reflecting on advances in ophthalmology}, volume = {12}, year = {2025}, }
• (2025). Delayed administration of IGFBP7 improved bone defect healing via ZO-1 dependent vessel stabilization. ADVS, 12(6), 2406965. (www)

  @article{ , abstract = {The vascular response following injury is pivotal for successful bone-defect repair but constitutes a major hurdle in the field of regenerative medicine. Throughout this process, vessel stabilization is crucial to provide an adequate nutrient supply and facilitate efficient waste removal. Therefore, this study investigated whether promoting vascular stabilization improves bone defect repair outcomes. The findings show that insulin-like growth factor-binding protein (IGFBP) 7 exhibits a novel biological function in attenuating vascular permeability and enhancing vascular wall integrity. The potential underlying mechanism involves the up-regulation of insulin-like growth factor 1 receptor (IGF1R) expression by IGFBP7 on endothelial cell membrane, followed by activation of the downstream PI3K/AKT signaling pathway and upregulated expression of the tight junction protein zonula occludens-1 (ZO-1). IGFBP7 delayed administration in mice with cranial defects significantly improved bone defect healing by increasing ZO-1 and CD31 co-localization within vessel walls and optimizing the perfusion function of the final vascular network. Furthermore, the application of the typical tight junction regulator AT1001 effectively promoted ZO-1-dependent vascular stabilization and facilitated bone defect repair. This study presents a new approach to enhance bone defect healing via vascular stabilization-targeted interventions and significantly advances the understanding of the complex interplay between osteogenesis and angiogenesis in bone defect healing.}, archive = {J_ADVS}, author = {Shiyu Sun and Yao Li and Yuman Li and Yuting Niu and Zhewen Hu and Chenyu Deng and Yiming Chen and Bo Hu and Ying Huang and Xuliang Deng}, doi = {10.1002/advs.202406965}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2406965}, shortjournal = {Adv. Sci.}, title = {Delayed administration of IGFBP7 improved bone defect healing via ZO-1 dependent vessel stabilization}, volume = {12}, year = {2025}, }
• (2025). Light-activatable ubiquitin for studying linkage-specific ubiquitin chain formation kinetics. ADVS, 12(6), 2406570. (www)

  @article{ , abstract = {Ubiquitination is a dynamic post-translational modification governing protein abundance, function, and localization in eukaryotes. The Ubiquitin protein is conjugated to lysine residues of target proteins, but can also repeatedly be ubiquitinated itself, giving rise to a complex code of ubiquitin chains with different linkage types. To enable studying the cellular dynamics of linkage-specific ubiquitination, light-activatable polyubiquitin chain formation is reported here. By incorporating a photocaged lysine at specific sites within ubiquitin through amber codon suppression, light-dependent activation of ubiquitin chain extension is enabled for the monitoring of linkage-specific polyubiquitination. The studies reveal rapid, minute-scale ubiquitination kinetics for K11, K48, and K63 linkages. The role of individual components of the ubiquitin-proteasome system in K48-initiated chain synthesis is further studied by small molecule inhibition. The approach expands current perturbation strategies with the ability to control linkage-specific ubiquitination with high temporal resolution and should find broad application for studying ubiquitinome dynamics.}, archive = {J_ADVS}, author = {Sudakshina Banerjee and Zeyneb Vildan Cakil and Kai Gallant and Johannes van den Boom and Shubhendu Palei and Hemmo Meyer and Malte Gersch and Daniel Summerer}, doi = {10.1002/advs.202406570}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2406570}, shortjournal = {Adv. Sci.}, title = {Light-activatable ubiquitin for studying linkage-specific ubiquitin chain formation kinetics}, volume = {12}, year = {2025}, }
• (2025). Periodic table of immunomodulatory elements and derived two-dimensional biomaterials. ADVS, 12(6), 2406324. (www)

  @article{ , abstract = {Periodic table of chemical elements serves as the foundation of material chemistry, impacting human health in many different ways. It contributes to the creation, growth, and manipulation of functional metallic, ceramic, metalloid, polymeric, and carbon-based materials on and near an atomic scale. Recent nanotechnology advancements have revolutionized the field of biomedical engineering to tackle longstanding clinical challenges. The use of nano-biomaterials has gained traction in medicine, specifically in the areas of nano-immunoengineering to treat inflammatory and infectious diseases. Two-dimensional (2D) nanomaterials have been found to possess high bioactive surface area and compatibility with human and mammalian cells at controlled doses. Furthermore, these biomaterials have intrinsic immunomodulatory properties, which is crucial for their application in immuno-nanomedicine. While significant progress has been made in understanding their bioactivity and biocompatibility, the exact immunomodulatory responses and mechanisms of these materials are still being explored. Current work outlines an innovative “immunomodulatory periodic table of elements” beyond the periodic table of life, medicine, and microbial genomics and comprehensively reviews the role of each element in designing immunoengineered 2D biomaterials in a group-wise manner. It recapitulates the most recent advances in immunomodulatory nanomaterials, paving the way for the development of new mono, hybrid, composite, and hetero-structured biomaterials.}, archive = {J_ADVS}, author = {Alireza Rafieerad and Leena Regi Saleth and Soofia Khanahmadi and Ahmad Amiri and Keshav Narayan Alagarsamy and Sanjiv Dhingra}, doi = {10.1002/advs.202406324}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2406324}, shortjournal = {Adv. Sci.}, title = {Periodic table of immunomodulatory elements and derived two-dimensional biomaterials}, volume = {12}, year = {2025}, }
• (2025). Suppression of hepatocyte ferroptosis via USP19-mediated deubiquitination of SLC7A11 in ischemia-free liver transplantation. ADVS, 12(6), 2406200. (www)

  @article{ , abstract = {Ischemia-free liver transplantation (IFLT) is developed as a novel clinical approach to avoid ischemia-reperfusion injury (IRI). This study aims to identify the most distinguished programmed cell death pathway in grafts undergoing IFLT versus conventional liver transplantation (CLT) and to explore the underlying mechanism. Ferroptosis is the most distinct programmed cell death form between IFLT and CLT grafts. Among various cell death inhibitors, the ferroptosis inhibitor (Ferrostain-1) is the most effective one to prevent hepatocytes from damage induced by oxygen deprivation/reoxygenation (OGD/R). Hepatocyte ferroptosis is significantly alleviated in IFLT versus CLT grafts in both human beings and pigs. Ubiquitination enzyme screening identifies augmented amounts of ubiquitin-specific protease 19 (USP19) in IFLT versus CLT grafts. The upregulation of USP19 in the grafts is correlated with reduced pathological Suzuki's score, lower post-transplant peak liver enzyme level, and less early allograft dysfunction in liver transplant recipients. USP19 overexpression mitigates post-transplant liver injury in mice. Mechanistically, USP19 inhibits the degradation of solute carrier family 7 member 11 (SLC7A11) by removing its K63-linked ubiquitin chains. Notably, USP19 overexpression reduces ferroptosis and IRI in a SLC7A11-dependent manner in mice. Collectively, USP19-mediated suppression of hepatocyte ferroptosis via deubiquitinating SLC7A11 is a key mechanism by which IFLT abrogates graft IRI.}, archive = {J_ADVS}, author = {Jinghong Xu and Shirui Chen and Di Liu and Qi Zhang and Tao Luo and Jiaxing Zhu and Liang Zhou and Yuan Lin and Hongyu Pan and Yichao Chen and Qiang Zhao and Tielong Wang and Schlegel Andrea and Björn Nashan and Tullius G. Stefan and Changjie Cai and Jun Cui and Xiaoshun He and Zhiyong Guo}, doi = {10.1002/advs.202406200}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2406200}, shortjournal = {Adv. Sci.}, title = {Suppression of hepatocyte ferroptosis via USP19-mediated deubiquitination of SLC7A11 in ischemia-free liver transplantation}, volume = {12}, year = {2025}, }
• (2025). Swimming by spinning: Spinning-top type rotations regularize sperm swimming into persistently progressive paths in 3D. ADVS, 12(6), 2406143. (www)

  @article{ , abstract = {Sperm swimming is essential for reproduction, with movement strategies adapted to specific environments. Sperm navigate by modulating the symmetry of their flagellar beating, but how they swim forward with asymmetrical beats remains unclear. Current methods lack the ability to robustly detect the flagellar symmetry state in free-swimming spermatozoa, despite its importance in understanding sperm motility. This study uses numerical simulations to investigate the fluid mechanics of sperm swimming with asymmetrical flagellar beats. Results show that sperm rotation regularizes the swimming motion, allowing persistently progressive swimming even with asymmetrical flagellar beats. Crucially, 3D sperm head orientation, rather than the swimming path, provides critical insight into the flagellar symmetry state. Sperm rotations during swimming closely resemble spinning-top dynamics, with sperm head precession driven by the helical beating of the flagellum. These results may prove essential in future studies on the role of symmetry in microorganisms and artificial swimmers, as body orientation detection has been largely overlooked in favor of swimming path analysis. Altogether, this rotational mechanism provides a reliable solution for forward propulsion and navigation in nature, which would otherwise be challenging for flagella with broken symmetry.}, archive = {J_ADVS}, author = {Xiaomeng Ren and Hermes Bloomfield-Gadêlha}, doi = {10.1002/advs.202406143}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2406143}, shortjournal = {Adv. Sci.}, title = {Swimming by spinning: Spinning-top type rotations regularize sperm swimming into persistently progressive paths in 3D}, volume = {12}, year = {2025}, }
• (2025). Biomimetic vascularized iPSC-hepatocyte spheroids for liver regeneration. ADVS, 12(6), 2405662. (www)

  @article{ , abstract = {Human induced pluripotent stem cell derived hepatocytes (hiPSC-heps) hold promising value for acute liver failure (ALF) treatment, while their therapeutic efficacy is usually limited by low cell bioactivity and untargeted in vivo accumulation. Here, inspired by vascularity supporting cellular architectures in the tissues and organs, a novel vascularized hiPSC-heps spheroid based on microfluidic microcapsules is presented for liver repair via orthotopic transplantation. The microcapsules are comprised of aqueous cores that facilitate hiPSC-hep aggregating into spheroids, and hybrid hydrogel shells of sodium alginate and hyaluronic acid methacryloyl (HAMA). By selectively degrading the alginate, the microcapsules are imparted with porous HAMA shells, which not only allowed human umbilical vein endothelial cells (HUVECs) to attach and form vascularized networks, but also facilitated communication between HUVECs and hiPSC-heps. The specific spatial distributions of these cells in the vascularized hiPSC-hep spheroids can provide nutrition support, promote the hepatic functions, and avoid immune cell attacks. Based on these features, it is illustrated that the vascularized hiPSC-hep spheroids can repair the acute failing liver more effectively, indicating their practical values in clinical liver repair.}, archive = {J_ADVS}, author = {Jinglin Wang and Danqing Huang and Haozhen Ren and Yuanjin Zhao}, doi = {10.1002/advs.202405662}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2405662}, shortjournal = {Adv. Sci.}, title = {Biomimetic vascularized iPSC-hepatocyte spheroids for liver regeneration}, volume = {12}, year = {2025}, }
• (2025). Accurate diagnosis of lower respiratory infections using host response and respiratory microbiome from a single metatranscriptome test of bronchoalveolar lavage fluid. ADVS, 12(6), 2405087. (www)

  @article{ , abstract = {Lower respiratory tract infections (LRTIs) diagnosis is challenging because noninfectious diseases mimic its clinical features. The altered host response and respiratory microbiome following LRTIs have the potential to differentiate LRTIs from noninfectious respiratory diseases (non-LRTIs). Patients suspected of having LRTIs are retrospectively enrolled and a clinical metatranscriptome test is performed on bronchoalveolar lavage fluid (BALF). Transcriptomic and metagenomic analysis profiled the host response and respiratory microbiome in patients with confirmed LRTI ( n = 126) or non-LRTIs ( n = 75). Patients with evidenced LRTIs exhibited enhanced pathways on chemokine and cytokine response, neutrophile recruitment and activation, along with specific gene modules linked to LRTIs status and key blood markers. Moreover, LRTIs patients exhibited reduced diversity and evenness in the lower respiratory microbiome, likely driven by an increased abundance of bacterial pathogens. Host marker genes are selected, and classifiers are developed to distinguish patients with LRTIs, non-LRTIs, and indeterminate status, achieving an area under the receiver operating characteristic curve of 0.80 to 0.86 and validated in a subsequently enrolled cohort. Incorporating respiratory microbiome features further enhanced the classifier's performance. In summary, a single metatranscriptome test of BALF proved detailed profiles of host response and respiratory microbiome, enabling accurate LRTIs diagnosis.}, archive = {J_ADVS}, author = {Xiaohui Zou and Mengwei Yan and Yeming Wang and Yawen Ni and Jiankang Zhao and Binghuai Lu and Bo Liu and Bin Cao}, doi = {10.1002/advs.202405087}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2405087}, shortjournal = {Adv. Sci.}, title = {Accurate diagnosis of lower respiratory infections using host response and respiratory microbiome from a single metatranscriptome test of bronchoalveolar lavage fluid}, volume = {12}, year = {2025}, }
• (2025). Nuclear control of mitochondrial homeostasis and venetoclax efficacy in AML via COX4I1. ADVS, 12(6), 2404620. (www)

  @article{ , abstract = {Cell signaling pathways are enriched for biological processes crucial for cellular communication, response to external stimuli, and metabolism. Here, a cell signaling-focused CRISPR screen identified cytochrome c oxidase subunit 4 isoform 1 (COX4I1) as a novel vulnerability in acute myeloid leukemia (AML). Depletion of COX4I1 hindered leukemia cell proliferation and impacted in vivo AML progression. Mechanistically, loss of COX4I1 induced mitochondrial stress and ferroptosis, disrupting mitochondrial ultrastructure and oxidative phosphorylation. CRISPR gene tiling scans, coupled with mitochondrial proteomics, dissected critical regions within COX4I1 essential for leukemia cell survival, providing detailed insights into the mitochondrial Complex IV assembly network. Furthermore, COX4I1 depletion or pharmacological inhibition of Complex IV (using chlorpromazine) synergized with venetoclax, providing a promising avenue for improved leukemia therapy. This study highlights COX4I1, a nuclear encoded mitochondrial protein, as a critical mitochondrial checkpoint, offering insights into its functional significance and potential clinical implications in AML.}, archive = {J_ADVS}, author = {Leisi Zhang and Honghai Zhang and Ting-Yu Wang and Mingli Li and Anthony K.N. Chan and Hyunjun Kang and Lai C. Foong and Qiao Liu and Sheela Pangeni Pokharel and Nicole M. Mattson and Priyanka Singh and Zeinab Elsayed and Benjamin Kuang and Xueer Wang and Steven T. Rosen and Jianjun Chen and Lu Yang and Tsui-Fen Chou and Rui Su and Chun-Wei David Chen}, doi = {10.1002/advs.202404620}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2404620}, shortjournal = {Adv. Sci.}, title = {Nuclear control of mitochondrial homeostasis and venetoclax efficacy in AML via COX4I1}, volume = {12}, year = {2025}, }
• (2025). Synergistic anticancer strategy targeting ECM stiffness: Integration of matrix softening and mechanical signal transduction blockade in primary liver cancers. ADVS, 12(6), 2403040. (www)

  @article{ , abstract = {The development of primary liver cancer (hepatocellular carcinoma [HCC] and intrahepatic cholangiocarcinoma [ICC]) is linked to its physical microenvironment, particularly extracellular matrix (ECM) stiffness. Potential anticancer strategies targeting ECM stiffness include prevention/reversal of the stiffening process and disruption of the response of cancer cells to mechanical signals from ECM. However, each strategy has limitations. Therefore, the authors propose integrating them to maximize their strengths. Compared with HCC, ICC has a stiffer ECM and a worse prognosis. Therefore, ICC is selected to investigate mechanisms underlying the influence of ECM stiffness on cancer progression and application of the integrated anticancer strategy targeting ECM stiffness. In summary, immunofluorescence results for 181 primary liver cancer tissue chips (ICC, n = 91; HCC, n = 90) and analysis of TCGA mRNA-sequencing demonstrate that ECM stiffness can affect phenotypes of primary liver cancers. The YAP1/ABHD11-AS1/STAU2/ZYX/p-YAP1 pathway is a useful entry point for exploration of specific mechanisms of mechanical signal conduction from the ECM in ICC cells and their impact on cancer progression. Moreover, a synergistic anticancer strategy targeting ECM stiffness (ICCM@NPs + siABHD11-AS1@BAPN) is constructed by integrating ECM softening and blocking intracellular mechanical signal transduction in ICC and can provide insights for the treatment of cancers characterized by stiff ECM.}, archive = {J_ADVS}, author = {Zefeng Shen and Liye Tao and Yali Wang and Yiwei Zhu and Haoyu Pan and Yijun Li and Shi Jiang and Junhao Zheng and Jingwei Cai and Yang Liu and Kainan Lin and Shihao Li and Yifan Tong and Liqing Shangguan and Junjie Xu and Xiao Liang}, doi = {10.1002/advs.202403040}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2403040}, shortjournal = {Adv. Sci.}, title = {Synergistic anticancer strategy targeting ECM stiffness: Integration of matrix softening and mechanical signal transduction blockade in primary liver cancers}, volume = {12}, year = {2025}, }
• (2025). Aberrant chitinase 3-like 1 expression in basal cells contributes to systemic sclerosis fibrosis. ADVS, 12(6), 2310169. (www)

  @article{ , abstract = {Systemic sclerosis (SSc) is an autoimmune disease characterized by extensive skin and internal organ fibrosis. However, the mechanism underlying fibrosis remains unclear, and effective treatments for halting or reversing fibrosis are lacking. In this study, single-cell RNA sequencing is used to obtain a comprehensive overview of skin cells from patients with SSc and healthy controls. A subset of basal cells with high chitinase 3-like 1 (Chi3L1) expression, which potentially plays an important role in fibroblast activation, is identified in SSc. Subsequently, patients with SSc are present with increased expression of Chi3L1 in the skin and serum, and elevated serum levels are associated with skin induration and pulmonary function. Furthermore, Chi3L1 promoted the differentiation of SSc dermal fibroblasts into myofibroblasts, and Chi3L1-deficient (Chi3L1-/-) mice showed amelioration of fibrosis in a bleomycin-induced SSc (BLM-SSc) model. Mechanistically, Chi3L1 mediates fibroblast activation primarily by interacting with interleukin-17 receptor A (IL-17RA), thereby initiating downstream nuclear factor kappa B and mitogen-activated protein kinases signaling pathways. Moreover, the anti-fibrotic effect of IL-17RA antagonists in BLM-SSc mice is demonstrated. In conclusion, Chi3L1 is a potential biomarker for the degree of fibrosis in SSc. Chi3L1 and its receptor, IL-17RA, are promising therapeutic targets for patients with SSc.}, archive = {J_ADVS}, author = {Xiuyuan Wang and Tianbao Ye and Junxia Huang and Feifei Hu and Chengjie Huang and Bei Gu and Xinzhi Xu and Ji Yang}, doi = {10.1002/advs.202310169}, journal = {Advanced Science}, month = {2}, number = {6}, pages = {2310169}, shortjournal = {Adv. Sci.}, title = {Aberrant chitinase 3-like 1 expression in basal cells contributes to systemic sclerosis fibrosis}, volume = {12}, year = {2025}, }
• (2025). Profiling pro-inflammatory proteases as biomolecular signatures of material-induced subcutaneous host response in immuno-competent mice (Adv. sci. 5/2025). ADVS, 12(5), 2570028. (www)

  @article{ , archive = {J_ADVS}, author = {Nam M.P. Tran and Anh T.H. Truong and Dang T. Nguyen and Tram T. Dang}, doi = {10.1002/advs.202570028}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2570028}, shortjournal = {Adv. Sci.}, title = {Profiling pro-inflammatory proteases as biomolecular signatures of material-induced subcutaneous host response in immuno-competent mice (Adv. sci. 5/2025)}, volume = {12}, year = {2025}, }
• (2025). Platelet–Monocyte aggregate instigates inflammation and vasculopathy in kawasaki disease (Adv. sci. 5/2025). ADVS, 12(5), 2570027. (www)

  @article{ , archive = {J_ADVS}, author = {Yuan Zhang and Cuiping Jia and Manli Guo and Qian Chen and Ying Wen and Ting Wang and Yinyin Xie and Xuejiao Fan and Jingwen Gao and Timur O. Yarovinsky and Renjing Liu and Zhiyong Jiang and Mengmeng Wang and Jin Zhou and Di Che and Lanyan Fu and Richard Edelson and Xiaoqiong Gu and John Hwa and Wai Ho Tang}, doi = {10.1002/advs.202570027}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2570027}, shortjournal = {Adv. Sci.}, title = {Platelet–Monocyte aggregate instigates inflammation and vasculopathy in kawasaki disease (Adv. sci. 5/2025)}, volume = {12}, year = {2025}, }
• (2025). A study on the inflammatory response of the brain in neurosyphilis (Adv. sci. 5/2025). ADVS, 12(5), 2570026. (www)

  @article{ , archive = {J_ADVS}, author = {Qiyu Zhang and Jie Ma and Jia Zhou and Hanlin Zhang and Mansheng Li and Huizi Gong and Yujie Wang and Heyi Zheng and Jun Li and Ling Leng}, doi = {10.1002/advs.202570026}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2570026}, shortjournal = {Adv. Sci.}, title = {A study on the inflammatory response of the brain in neurosyphilis (Adv. sci. 5/2025)}, volume = {12}, year = {2025}, }
• (2025). Resensitizing β-lactams by reprogramming purine metabolism in small colony variant for osteomyelitis treatment (Adv. sci. 5/2025). ADVS, 12(5), 2570025. (www)

  @article{ , archive = {J_ADVS}, author = {Tingwang Shi and Qiong Wu and Zesong Ruan and Zhiyuan Luo and Wenbo Wang and Zhao Guo and Yihong Ma and Xin Wang and Guangyu Chu and Han Lin and Min Ge and Yunfeng Chen}, doi = {10.1002/advs.202570025}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2570025}, shortjournal = {Adv. Sci.}, title = {Resensitizing β-lactams by reprogramming purine metabolism in small colony variant for osteomyelitis treatment (Adv. sci. 5/2025)}, volume = {12}, year = {2025}, }
• (2025). Correction to “Preclinical efficacy and safety evaluation of AAV-OTOF in DFNB9 mouse model and nonhuman primate”. ADVS, 12(5), 2416185. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202416185}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2416185}, shortjournal = {Adv. Sci.}, title = {Correction to “Preclinical efficacy and safety evaluation of AAV-OTOF in DFNB9 mouse model and nonhuman primate”}, volume = {12}, year = {2025}, }
• (2025). Correction to “AAV-mediated gene cocktails enhance supporting cell reprogramming and hair cell regeneration”. ADVS, 12(5), 2416025. (www)

  @article{ , archive = {J_ADVS}, author = {Liyan Zhang and Xin Chen and Xinlin Wang and Yinyi Zhou and Yuan Fang and Xingliang Gu and Ziyu Zhang and Qiuhan Sun and Nianci Li and Lei Xu and Fangzhi Tan and Renjie Chai and Jieyu Qi}, doi = {10.1002/advs.202416025}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2416025}, shortjournal = {Adv. Sci.}, title = {Correction to “AAV-mediated gene cocktails enhance supporting cell reprogramming and hair cell regeneration”}, volume = {12}, year = {2025}, }
• (2025). Lattice stabilized and emission tunable pure-bromide quasi-2D perovskite for air-processed blue light-emitting diodes. ADVS, 12(5), 2414499. (www)

  @article{ , abstract = {Realizing air-processed blue halide perovskite films with tailored emission is significant for promoting the commercialization of perovskite light-emitting diodes (PeLEDs). However, the intrinsically inferior thermodynamic stability and laborious crystallization kinetics control under humidity interference limit the fabrication of blue perovskite emitters in ambient air. Here, air-processed pure-bromide quasi-2D blue perovskite films are achieved with stabilized lattice and tunable emission by interstitial doping of trivalent metallic cations. This strategy improves the formation energy of the perovskite lattice, promotes energy transfer between different n phases, and suppresses intrinsic electron-phonon coupling in the perovskite films. The emission-controllable blue PeLEDs are fabricated in ambient air for the first time. The champion deep blue PeLED shows maximum external quantum efficiency (EQE) of 2.05% and luminance of 246.56 cd m −2 , which are comparable to the state-of-the-art of similar devices fabricated in glovebox. The work pioneers a simple method of electronic structure engineering to tune the emission of air-processed blue perovskite, breaking the limitations of thermodynamic stability and crystallization kinetics control of perovskite in ambient air.}, archive = {J_ADVS}, author = {Yangyang Guo and Penghui Yang and Fan Dong and Huixin Li and Jialiang Gao and Zeyi Cheng and Jiandong Wu and Yadong Xu and Hongyue Wang and Hongqiang Wang}, doi = {10.1002/advs.202414499}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2414499}, shortjournal = {Adv. Sci.}, title = {Lattice stabilized and emission tunable pure-bromide quasi-2D perovskite for air-processed blue light-emitting diodes}, volume = {12}, year = {2025}, }
• (2025). Directly gel-thermal processing of linker-mixed crystal-glass composite membranes for sorption-preferential gas separation. ADVS, 12(5), 2413942. (www)

  @article{ , abstract = {Membrane processes are promising for energy-saving industrial applications. However, efficient separation for some valuable gas mixtures with similar characteristics, such as CH 4 /N 2 and O 2 /N 2 , remains extremely challenging. Metal–organic framework (MOF) membranes have been attracting intensive attention for gas sieving, but it is difficult to manufacture MOF membranes in scalability and precisely tune their transport property. In this study, Gel-thermal processing of linker-mixed MOF crystal-glass composite membranes is reported directly, with the mechanism of adjusting metal-linker bond strengths and angles to disrupt long-range periodicity of MOFs and promote glass phase formation, for sharply sorption-preferential gas separation. This strategy can be realized by using a simple, solvent/precursor-less, and cost-effective gel-thermal approach with two steps of gel coating and thermal conversion, thereby constructing crystal-glass composite membranes in a controllable, processable, versatile, and environmentally friendly route. Moreover, the mixed linkers enable preferential gas affinities and the ultramicroporous glasses can eliminate any membrane defects. The membranes exhibit outstanding gas separation performance for the challenging systems of CH 4 /N 2 and O 2 /N 2 , with mixture selectivities up to 9.3 and 9.6, respectively, far exceeding those of polymer, MOF, and mixed-matrix membranes. The study provides an available route for architecting high-performance membranes for gas separations.}, archive = {J_ADVS}, author = {Yihao Xiao and Yanqing Yu and Xinxi Huang and Da Chen and Wanbin Li}, doi = {10.1002/advs.202413942}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2413942}, shortjournal = {Adv. Sci.}, title = {Directly gel-thermal processing of linker-mixed crystal-glass composite membranes for sorption-preferential gas separation}, volume = {12}, year = {2025}, }
• (2025). Dual inhibition of CDK4/6 and CDK7 suppresses triple-negative breast cancer progression via epigenetic modulation of SREBP1-regulated cholesterol metabolism. ADVS, 12(5), 2413103. (www)

  @article{ , abstract = {Inhibitors targeting cyclin-dependent kinases 4 and 6 (CDK4/6) to block cell cycle progression have been effective in treating hormone receptor-positive breast cancer, but triple-negative breast cancer (TNBC) remains largely resistant, limiting their clinical applicability. The study reveals that transcription regulator cyclin-dependent kinase7 (CDK7) is a promising target to circumvent TNBC's inherent resistance to CDK4/6 inhibitors. Combining CDK4/6 and CDK7 inhibitors significantly enhances therapeutic effectiveness, leading to a marked decrease in cholesterol biosynthesis within cells. This effect is achieved through reduced activity of the transcription factor forkhead box M1 (FOXM1), which normally increases cholesterol production by inducing SREBF1 expression. Furthermore, this dual inhibition strategy attenuates the recruitment of sterol regulatory element binding transcription factor 1 (SREBP1) and p300 to genes essential for cholesterol synthesis, thus hindering tumor growth. This research is corroborated by an in-house cohort showing lower survival rates in TNBC patients with higher cholesterol production gene activity. This suggests a new treatment approach for TNBC by simultaneously targeting CDK4/6 and CDK7, warranting additional clinical trials.}, archive = {J_ADVS}, author = {Yilan Yang and Jiatao Liao and Zhe Pan and Jin Meng and Li Zhang and Wei Shi and Xiaofang Wang and Xiaomeng Zhang and Zhirui Zhou and Jurui Luo and Xingxing Chen and Zhaozhi Yang and Xin Mei and Jinli Ma and Zhen Zhang and Yi-Zhou Jiang and Zhi-Min Shao and Fei Xavier Chen and Xiaoli Yu and Xiaomao Guo}, doi = {10.1002/advs.202413103}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2413103}, shortjournal = {Adv. Sci.}, title = {Dual inhibition of CDK4/6 and CDK7 suppresses triple-negative breast cancer progression via epigenetic modulation of SREBP1-regulated cholesterol metabolism}, volume = {12}, year = {2025}, }
• (2025). CDC20-mediated selective autophagy degradation of PBRM1 affects immunotherapy for renal cell carcinoma. ADVS, 12(5), 2412967. (www)

  @article{ , abstract = {Polybromo 1 (PBRM1) inactivating mutations are associated with clinical benefit from immune checkpoint inhibitor treatments in clear cell renal cell carcinoma (ccRCC). However, whether targeting PBRM1 has the potential to enhance immunotherapy efficacy in patients with wild-type PBRM1 and the upstream pathways that regulate PBRM1 protein stability remain unclear. Here, it is demonstrated that PBRM1 knockdown induced M1 macrophage polarization and infiltration, which enhanced the efficacy of anti-PD-1 immunotherapy in RCC. Meanwhile, CDC20 catalyzes K27 ubiquitination of PBRM1 and promotes its degradation via p62-mediated selective autophagy. A bicyclic peptide (PB1-p62) is designed and constructed to target PBRM1 and p62, thereby promoting the degradation of PBRM1. As a result, the efficacy of anti-PD-1 immunotherapy is enhanced, leading to improved overall survival rates in syngeneic mouse tumor models. Overall, this finding suggest the clinical application of PB1-p62 and provide a novel approach for enhancing the effectiveness of immunotherapy in RCC patients with wild-type PBRM1.}, archive = {J_ADVS}, author = {Yizeng Fan and Weichao Dan and Taotao Que and Yi Wei and Bo Liu and Zixi Wang and Yulin Zhang and Yuzhao Wang and Tianjie Liu and Yanxin Zhuang and Mengxing Li and Chendong Guo and Jin Zeng and Bohan Ma and Lei Li}, doi = {10.1002/advs.202412967}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412967}, shortjournal = {Adv. Sci.}, title = {CDC20-mediated selective autophagy degradation of PBRM1 affects immunotherapy for renal cell carcinoma}, volume = {12}, year = {2025}, }
• (2025). Palmitic acid accelerates endothelial cell injury and cardiovascular dysfunction via palmitoylation of PKM2. ADVS, 12(5), 2412895. (www)

  @article{ , abstract = {High serum level of palmitic acid(PA) is implicated in pathogenesis of cardiovascular diseases. PA serves as the substrate for protein palmitoylation. However, it is still unknown whether palmitoylation is involved in PA-induced cardiovascular dysfunction. Here, in clinical cohort studies of 1040 patients with coronary heart disease, high level of PA is associated with risk of major adverse cardiovascular events (MACE) and death. In ApoE −/− mice, 10 mg/kg −1 PA treatment induces blood pressure elevation, cardiac contractile dysfunction, endothelial dysfunction and atherosclerotic plaqueformation. In endothelial cells, inhibition of palmitoylation bypalmitoyl-transferase inhibitor 2-BP eliminates PA-induced endothelial injury, whereas promotion of palmitoylation by depalmitoylase inhibitor ML349 exacerbates the harmful effect of PA. Palmitoyl-proteomics analysis identifies pyruvate kinase isozyme type M2 (PKM2) as the palmitoylated protein responsible for PA-induced endothelial injury, and Cys31 as the predominant palmitoylated site. PKM2-C31S mutants (cysteine replaced by serine) prevents PA-induced endothelial injury. Endothelial-specific AAV-C31S PKM2 endo ameliorates cardiovascular dysfunction caused by PA in ApoE −/− mice. Mechanistically, PKM2-C31 palmitoylation impairs PKM2 tetramerization to inhibit its pyruvate kinase activity and endothelial glycolysis. Finally, zDHHC13 is identified as the palmitoyl acyltransferase of PKM2. In conclusion, these findings suggest that PKM2-C31 palmitoylation contributes to PA-induced endothelial injury and cardiovascular dysfunction.}, archive = {J_ADVS}, author = {Yu He and Senlin Li and Lujing Jiang and Kejue Wu and Shanshan Chen and Linjie Su and Cui Liu and Peiqing Liu and Wenwei Luo and Shilong Zhong and Zhuoming Li}, doi = {10.1002/advs.202412895}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412895}, shortjournal = {Adv. Sci.}, title = {Palmitic acid accelerates endothelial cell injury and cardiovascular dysfunction via palmitoylation of PKM2}, volume = {12}, year = {2025}, }
• (2025). In situ modulation of NiFeOOH coordination environment for enhanced electrocatalytic-conversion of glucose and energy-efficient hydrogen production. ADVS, 12(5), 2412872. (www)

  @article{ , abstract = {Glucose electrocatalytic-conversion reaction (GCR) is a promising anode reaction to replace the slow oxygen evolution reaction (OER), thus promoting the development of hydrogen production by electrochemical water splitting. Herein, NiFe-based metal-organic framework (MOF) is used as a precursor to prepare W-doped nickel-iron phosphide (W-NiFeP) nanosheet arrays by ion exchange and phosphorylation, which exhibit a high electrocatalytic activity toward the hydrogen evolution reaction (HER), featuring an overpotential of only −179 mV to achieve the current density of 100 mA cm −2 in alkaline media. Notably, electrochemical activation of W-NiFeP facilitates the in situ formation of phosphate groups producing W,P-NiFeOOH, which, in conjunction with the W co-doped amorphous layers, leads to a high electrocatalytic performance toward GCR, due to enhanced proton transfer and adsorption of reaction intermediates, as confirmed in experimental and theoretical studies. Thus, the two-electrode electrolyzer of the W-NiFeP/NF||W,P-NiFeOOH/NF for HER||GCR needs only a low cell voltage of 1.56 V to deliver 100 mA cm −2 at a remarkable hydrogen production efficiency of 1.86 mmol h −1 , with a high glucose conversion (98.0%) and formic acid yields (85.2%). Results from this work highlight the significance of the development of effective electrocatalysts for biomass electrocatalytic-conversion in the construction of high-efficiency electrolyzers for green hydrogen production.}, archive = {J_ADVS}, author = {Ning Wei and Sufeng Zhang and Xue Yao and Qinglu Li and Nan Li and Jinrui Li and Dingjie Pan and Qiming Liu and Shaowei Chen and Scott Renneckar}, doi = {10.1002/advs.202412872}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412872}, shortjournal = {Adv. Sci.}, title = {In situ modulation of NiFeOOH coordination environment for enhanced electrocatalytic-conversion of glucose and energy-efficient hydrogen production}, volume = {12}, year = {2025}, }
• (2025). Porous deep eutectic Solvents–Unfulfilled dream or the next breakthrough in scientific innovation?. ADVS, 12(5), 2412622. (www)

  @article{ , abstract = {Porous deep eutectic solvents (PDES) are capturing the imagination of scientists, promising a revolutionary leap in material science. These innovative materials, blending the versatility of deep eutectic solvents (DES) with the intricate architectures of porous structures, offer an exciting array of applications—from green chemistry and catalysis to energy storage and environmental remediation. However, the journey from laboratory curiosity to industrial application is fraught with challenges. This perspective article analyzes the realm of PDES, scrutinizing the cutting-edge advancements and the challenges that lie ahead. By exploring their synthesis, unique properties, and diverse application potential, the critical question is asked: are PDES an unfulfilled dream or the next big breakthrough in scientific innovation? A comprehensive analysis reveals a “landscape” ripe with opportunity, suggesting that with targeted research and development, PDES can indeed become a cornerstone technology, driving progress across multiple scientific domains.}, archive = {J_ADVS}, author = {Marcin Wysokowski and Patrycja Makoś-Chełstowska and Alina Brzęczek-Szafran and Aleksandra Sikora and Adam Gorczyński and Teofil Jesionowski}, doi = {10.1002/advs.202412622}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412622}, shortjournal = {Adv. Sci.}, title = {Porous deep eutectic Solvents–Unfulfilled dream or the next breakthrough in scientific innovation?}, volume = {12}, year = {2025}, }
• (2025). Covalent organic frameworks for membrane separation. ADVS, 12(5), 2412600. (www)

  @article{ , abstract = {Membranes with switchable wettability, solvent resistance, and toughness have emerged as promising materials for separation applications. However, challenges like limited mechanical strength, poor chemical stability, and structural defects during membrane fabrication hinder their widespread adoption. Covalent organic frameworks (COFs), crystalline materials constructed from organic molecules connected by covalent bonds, offer a promising solution due to their high porosity, stability, and customizable properties. The ordered structures and customizable functionality provide COFs with a lightweight framework, large surface area, and tunable pore sizes, which have attracted increasing attention for their applications in membrane separations. Recent research has extensively explored the preparation strategies of COF membranes and their applications in various separation processes. This review uniquely delves into the influence of various COF membrane fabrication techniques, including interfacial polymerization, layer-by-layer assembly, and in situ growth, on membrane thickness and performance. It comprehensively explores the design strategies and potential applications of these methods, with a particular focus on gas separation, oil/water separation, and organic solvent nanofiltration. Furthermore, future opportunities, challenges within this field, and potential directions for future development are proposed.}, archive = {J_ADVS}, author = {Yuan-Hang Jin and Meng-Hao Li and Ying-Wei Yang}, doi = {10.1002/advs.202412600}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412600}, shortjournal = {Adv. Sci.}, title = {Covalent organic frameworks for membrane separation}, volume = {12}, year = {2025}, }
• (2025). Multistage regulation strategy via fluorine-rich small molecules for realizing high-performance perovskite solar cells. ADVS, 12(5), 2412557. (www)

  @article{ , abstract = {Perovskite solar cells (PSCs) are an ideal candidate for next-generation photovoltaic applications but face many challenges for their wider application, including uncontrolled fast crystallization, trap-assisted nonradiative recombination, and inefficient charge transport. Herein, a multistage regulation (MSR) strategy for addressing these challenges is proposed via the introduction of fluorine-rich small molecules with multiple active points (i.e., 1-[Bis(trifluoromethanesulfonyl)methyl]- 2,3,4,5,6-pentafluorobenzene (TFSP)) into the precursor solution of the perovskite film. The addition of TFSP effectively delays and regulates the crystallization and growth process of the perovskite film for larger grains and fewer defects, and it effectively improves the coverage of self-assembled molecules for efficient charge transport. The multiple active points of TFSP induce a strong binding affinity with uncoordinated defects in the perovskite film. Moreover, the high fluorine content of TFSP induces strong electronegativity to establish a high binding strength between the perovskite film and electron transport layer. Finally, PSCs prepared by the MSR strategy demonstrated an optimal power conversion efficiency (PCE) of 25.46% and maintained 91.16% of the initial PCE under nonpackaged air conditions and at a relative humidity of 45% after 3000 h.}, archive = {J_ADVS}, author = {Xiong Chang and Kunpeng Li and Yong Han and Guohua Wang and Zhishan Li and Dongfang Li and Fashe Li and Xing Zhu and Hua Wang and Jiangzhao Chen and Tao Zhu}, doi = {10.1002/advs.202412557}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412557}, shortjournal = {Adv. Sci.}, title = {Multistage regulation strategy via fluorine-rich small molecules for realizing high-performance perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). High relative humidity-induced growth of perovskite nanowires from glass toward single-mode photonic nanolasers at sub-100-nm scale. ADVS, 12(5), 2412397. (www)

  @article{ , abstract = {Metal halide perovskites (MHPs) have achieved substantial progress in their applications; however, their ionic crystal character and low formation energy result in poor structural stability and limited morphological tunability. In particular, high relative humidity (RH) commonly causes severe MHP degradation, which poses a major obstacle to long-term device operation. Herein, high RH-induced growth of anisotropic MHP structures on glass surfaces is reported under 25 °C and atmospheric conditions on a basis of glass corrosion by moisture. Nanowires (NWs) with tunable length and composition are obtained under 85% RH air, and water molecule-induced facet engineering of perovskite is established for anisotropic growth. Importantly, single-mode photonic lasing in these MHP NWs with thickness at sub-100-nm scale (down to 75 nm ∼ 1/7 lasing wavelength) is achieved via both one-photon and multiphoton pumping. These nanowire lasers exhibited high quality factor (>3000), high degree of polarization (≈0.9), and excellent stability under laser irradiation. The work not only presents a distinctive technique for the growth of MHPs but also endows MHP NWs with new opportunities for nonlinear optics, strong light-matter interactions, and active photonic integrated devices.}, archive = {J_ADVS}, author = {Zhiqiang Wang and Xinkuo Li and Chenduan Chen and Minhan Lou and Jiajia Wu and Kai Gao and Zengling Li and Ke Sun and Zhou Li and Zhu Xiao and Linhan Li and Pan Wang and Sai Bai and Jianrong Qiu and Dezhi Tan}, doi = {10.1002/advs.202412397}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412397}, shortjournal = {Adv. Sci.}, title = {High relative humidity-induced growth of perovskite nanowires from glass toward single-mode photonic nanolasers at sub-100-nm scale}, volume = {12}, year = {2025}, }
• (2025). Bistable soft shells for programmable mechanical logic. ADVS, 12(5), 2412372. (www)

  @article{ , abstract = {Mechanical computing promises to integrate semiconductor-based digital logic in several applications, but it needs straightforward programmable devices for changing computing rules in situ. A methodology based on strain-governed, bistable soft shells that process digital information by interchanging their internal/external surfaces is proposed. This bistable behavior, explained via model-based design, safeguards robustness by working only once for each input pulse. Thus, these shells are leveraged to create a buffer and a NOT gate that lead to six fundamental gates (AND, OR, NAND, NOR, XOR, and XNOR). All these functions are integrated into a unique programmable device, making mechanically integrated circuits more adaptable with rule-changeable logic operations. This design ensures continuous processes and general applicability to multiple types of signals (a pressurized fluid can replace mechanical driving signals is shown). It also empowers more complex logic functions suitable for expanded applications, such as the half and full adders is addressed.}, archive = {J_ADVS}, author = {Nan Yang and Yuming Lan and Miao Zhao and Xiaofei Shi and Kunpeng Huang and Zhongfa Mao and Damiano Padovani}, doi = {10.1002/advs.202412372}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412372}, shortjournal = {Adv. Sci.}, title = {Bistable soft shells for programmable mechanical logic}, volume = {12}, year = {2025}, }
• (2025). A body-temperature-triggered in situ softening peripheral nerve electrode for chronic robust neuromodulation. ADVS, 12(5), 2412361. (www)

  @article{ , abstract = {Implantable peripheral nerve electrodes are crucial for monitoring health and alleviating symptoms of chronic diseases. Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue-like electrodes suffer from unmanageable operating forces, leading to high risks of nerve injury and fragile electrode-tissue interfaces. Here, a peripheral nerve electrode is developed that simultaneously fulfills the criteria of body temperature softening and tissue-like modulus (less than 0.8 MPa at 37 °C) after implantation. The central core is altered from the tri-arm crosslinker to the star-branched monomer to kill two birds (close the translation temperature to 37 °C and decrease the modulus after implantation) with one stone. Furthermore, the decreased interfacial impedance (325.1 ± 46.9 Ω at 1 kHz) and increased charge storage capacity (111.2 ± 5.8 mC cm −2 ) are achieved by an in situ electrografted conductive polymer on the strain-insensitive conductive network of Au nanotubes. The electrodes are readily wrapped around nerves and applied for long-term stimulation in vivo with minimal inflammation. Neuromodulation experiments demonstrate their potential clinical utility, including vagus nerve stimulation in rats to suppress seizures and alleviation of cardiac remodeling in a canine model of myocardial infarction.}, archive = {J_ADVS}, author = {Xueyang Ren and Wenjie Tang and Yuehui Yuan and Shisheng Chen and Fangzhou Lu and Jinyang Mao and Jidan Fan and Xufeng Wei and Ming Chu and Benhui Hu}, doi = {10.1002/advs.202412361}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412361}, shortjournal = {Adv. Sci.}, title = {A body-temperature-triggered in situ softening peripheral nerve electrode for chronic robust neuromodulation}, volume = {12}, year = {2025}, }
• (2025). Hydrogen-generating magnesium alloy seed strand sensitizes solid tumors to iodine-125 brachytherapy. ADVS, 12(5), 2412263. (www)

  @article{ , abstract = {Radioactive iodine-125 ( 125 I) seed implantation, a brachytherapy technique, effectively kills tumor cells via X-rays and gamma rays, serving as an alternative therapeutic option following the failure of frontline treatments for various solid tumors. However, tumor radioresistance limits its efficacy. Hydrogen gas has anticancer properties and can enhance the efficacy of immunotherapy. However, its role in radiotherapy sensitization has rarely been reported. Many current hydrogen delivery methods involve hydrogen-generating nanomaterials, such as magnesium-based nanomaterials. This study introduces an AZ31 magnesium alloy 125 I seed strand (termed AMASS) with pH-dependent slow-release hydrogen characteristics and excellent mechanical properties. AMASS can be implanted into tumors via minimally invasive surgery, releasing hydrogen around the 125 I seeds. In vitro experiments showed that hydrogen from AMASS degradation significantly inhibited tumor proliferation, increased apoptosis, disrupted redox homeostasis and mitochondrial membrane potential, reduced adenosine triphosphate levels, and induced DNA damage due to 125 I radiation. In mouse xenograft and rabbit liver tumor models, hydrogen from AMASS showed superior therapeutic effects compared with 125 I seeds alone, with no noticeable side effects. In addition, AMASS has a uniform radiation dose distribution and simple implantation. Therefore, hydrogen from AMASS enhanced 125 I seed efficacy, supporting the further promotion and application of 125 I seed implantation in cancer therapy.}, archive = {J_ADVS}, author = {Pan Hu and Letao Lin and Guanyu Chen and Dengyao Liu and Huanqing Guo and Meigui Xiao and Zhihui Zhong and Guang Yang and Bingchen Xu and Dongcun Huang and Sheng Peng and Yong Li and Yanling Zhang and Tao Huang and Fujun Zhang}, doi = {10.1002/advs.202412263}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412263}, shortjournal = {Adv. Sci.}, title = {Hydrogen-generating magnesium alloy seed strand sensitizes solid tumors to iodine-125 brachytherapy}, volume = {12}, year = {2025}, }
• (2025). All roads lead to rome: Pathways to engineering disease resistance in plants. ADVS, 12(5), 2412223. (www)

  @article{ , abstract = {Unlike animals, plants are unable to move and lack specialized immune cells and circulating antibodies. As a result, they are always threatened by a large number of microbial pathogens and harmful pests that can significantly reduce crop yield worldwide. Therefore, the development of new strategies to control them is essential to mitigate the increasing risk of crops lost to plant diseases. Recent developments in genetic engineering, including efficient gene manipulation and transformation methods, gene editing and synthetic biology, coupled with the understanding of microbial pathogenicity and plant immunity, both at molecular and genomic levels, have enhanced the capabilities to develop disease resistance in plants. This review comprehensively explains the fundamental mechanisms underlying the tug-of-war between pathogens and hosts, and provides a detailed overview of different strategies for developing disease resistance in plants. Additionally, it provides a summary of the potential genes that can be employed in resistance breeding for key crops to combat a wide range of potential pathogens and pests, including fungi, oomycetes, bacteria, viruses, nematodes, and insects. Furthermore, this review addresses the limitations associated with these strategies and their possible solutions. Finally, it discusses the future perspectives for producing plants with durable and broad-spectrum disease resistance.}, archive = {J_ADVS}, author = {Aziz Ul Ikram and Muhammad Saad Shoaib Khan and Faisal Islam and Sulaiman Ahmed and Tengfang Ling and Feng Feng and Zongtao Sun and Huan Chen and Jian Chen}, doi = {10.1002/advs.202412223}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412223}, shortjournal = {Adv. Sci.}, title = {All roads lead to rome: Pathways to engineering disease resistance in plants}, volume = {12}, year = {2025}, }
• (2025). WDR36 regulates trophectoderm differentiation during human preimplantation embryonic development through glycolytic metabolism. ADVS, 12(5), 2412222. (www)

  @article{ , abstract = {Mammalian pre-implantation development is a complex process involving sophisticated regulatory dynamics. WD repeat domain 36 (WDR36) is known to play a critical role in mouse early embryonic development, but its regulatory function in human embryogenesis is still elusive due to limited access to human embryos. The human pluripotent stem cell-derived blastocyst-like structure, termed a blastoid, offers an alternative means to study human development in a dish. In this study, after verifying that WDR36 inhibition disrupted polarization in mouse early embryos, it is further demonstrated that WDR36 interference can block human blastoid formation, dominantly hindering the trophectoderm lineage commitment. Both transcriptomics and targeted metabolomics analyses revealed that WDR36 interference downregulated glucose metabolism. WDR36 can interact with glycolytic metabolic protein lactate dehydrogenase A (LDHA), thereby positively regulating glycolysis during the late stage of human blastoid formation. Taken together, the study has established a mechanistic connection between WDR36, glucose metabolism, and cell fate determination during early embryonic lineage commitment, which may provide potential insights into novel therapeutic targets for early adverse pregnancy interventions.}, archive = {J_ADVS}, author = {Shiyu An and Shuyue Hou and Feifei Xu and Huanyu Yan and Wenyi Zhang and Jinfeng Xiang and Haoran Chen and Hanwen Zhang and Lingling Dong and Xiaobin Sun and Ran Huo and Yun Chen and Xi Wang and Yang Yang}, doi = {10.1002/advs.202412222}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412222}, shortjournal = {Adv. Sci.}, title = {WDR36 regulates trophectoderm differentiation during human preimplantation embryonic development through glycolytic metabolism}, volume = {12}, year = {2025}, }
• (2025). Ubiquitination of CD47 regulates innate anti-tumor immune response. ADVS, 12(5), 2412205. (www)

  @article{ , abstract = {In addition to adaptive immune checkpoint of PD-1/PD-L1, the innate immune checkpoint SIRPα/CD47 plays an important role in regulation of tumor immune escape. However, the mechanism of CD47 ubiquitination on tumor immune escape remains unclear. Here it is found that TRAF2 bound to the C-terminal of CD47 cytoplasmic fragment and induced its ubiquitination, leading to inhibition of CD47 autophagic degradation by disrupting its binding to LC3, which in turn inhibited macrophage phagocytosis and promoted tumor immune escape. In contrast, loss of TRAF2 facilitated CD47 autophagic degradation and inhibited tumor immune escape. Moreover, autophagy induction promoted CD47 degradation and enhanced the efficacy of CD47 antibody anti-tumor immunotherapy. These findings revealed a novel mechanism of ubiquitination of CD47 on tumor immune escape.}, archive = {J_ADVS}, author = {Qian Gou and Bingjun Yan and Yalan Duan and Yilei Guo and Jing Qian and Juanjuan Shi and Yongzhong Hou}, doi = {10.1002/advs.202412205}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2412205}, shortjournal = {Adv. Sci.}, title = {Ubiquitination of CD47 regulates innate anti-tumor immune response}, volume = {12}, year = {2025}, }
• (2025). Proline-selective electrochemiluminescence detecting a single amino acid variation between a1 and a2 β-casein containing milks. ADVS, 12(5), 2411956. (www)

  @article{ , abstract = {The proline amino acid and prolyl residues of peptides/proteins confer unique biological and biochemical properties that motivates the development of proline-selective analysis. The study focuses on one specific class of problem, the detection of single amino acid variants involving proline, and reports a Pro-selective electrochemiluminescence (ECL) method. To develop this method, the A1-/A2- variants of milk's β-casein protein are investigated because it is a well-established example and abundant samples are readily available. Specifically, β-casein has 209 amino acids with 34 (or 35) proline residues: the A1-variant has a Pro-to-His substitution at position 67 (relative to the A2 variant). The study shows that proline's strong luminescence allows the generic discrimination of: Pro from other amino acids; an A2-oligopeptide from an A1-oligopeptide; the A2-β-casein variant from the A1-variant; and commercially-available A2 milks from A1-containing regular milks. The evidence indicates that luminescence depends on proline content and accessibility, as well as signal quenching. Compared to conventional immunoassays, the ECL method is simple, rapid, and inexpensive. Further, the ECL-method is Pro-selective (vs molecularly-selective like typical immunoassays) which should make it broadly useful for studying the role of proline in biology and especially useful for tracking the digestion of proline-rich proteins in the diet.}, archive = {J_ADVS}, author = {Eunkyoung Kim and Chen-Yu Chen and Monica J. Chu and Mya F. Hamstra and William E. Bentley and Gregory F. Payne}, doi = {10.1002/advs.202411956}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411956}, shortjournal = {Adv. Sci.}, title = {Proline-selective electrochemiluminescence detecting a single amino acid variation between a1 and a2 β-casein containing milks}, volume = {12}, year = {2025}, }
• (2025). Switchable adhesion of hydrogels to plant and animal tissues. ADVS, 12(5), 2411942. (www)

  @article{ , abstract = {The ability to “switch on” adhesion between a thin hydrogel and a biological tissue can be useful in biomedical applications such as surgery. One way to accomplish this is with an electric field, a phenomenon termed electroadhesion (EA). Here, it is shown that cationic gels can be adhered by EA to tissues across all of biology . This includes tissues from animals, including humans and other mammals; birds; fish; reptiles (e.g., lizards); amphibians (e.g., frogs), and invertebrates (e.g., shrimp, worms). Gels can also be adhered to soft tissues from plants, including fruit (e.g., plums) and vegetables (e.g; carrot). In all cases, EA is induced by a low electric field (DC, 10 V) applied for a short time (20 s). After the field is removed, the adhesion persists. The adhesion can also be reversed by applying the field with opposite polarity. In mammals, EA is strong for many tissues (e.g., arteries, muscles, and cornea), but not others (e.g., adipose, brain). Tissues with anisotropic structure show anisotropic adhesion strength by EA. The higher the concentration of anionic polymers in a tissue, the stronger its adhesion to cationic gels. This underscores that EA is mediated by the electrophoresis of chain segments across the gel-tissue interface.}, archive = {J_ADVS}, author = {Leah K. Borden and Morine G. Nader and Faraz A. Burni and Samantha M. Grasso and Irene Orueta-Ortega and Mahima Srivastava and Paula Montero-Atienza and Metecan Erdi and Sarah L. Wright and Rajabrata Sarkar and Anthony D. Sandler and Srinivasa R. Raghavan}, doi = {10.1002/advs.202411942}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411942}, shortjournal = {Adv. Sci.}, title = {Switchable adhesion of hydrogels to plant and animal tissues}, volume = {12}, year = {2025}, }
• (2025). Triplet electron exchange in carbon nanodots-assisted long-persistent near-infrared chemiluminescence for oncology synergistic imaging and therapy. ADVS, 12(5), 2411898. (www)

  @article{ , abstract = {In classical photodynamic therapy, tumor cells are killed by the cytotoxic species via type-I/II photochemical reactions, seriously limited by the external photoexcitation and hypoxia. Herein, the electron transfer mechanism between fluorophores and peroxalate-H 2 O 2 reaction is investigated and the singlet/triplet electron exchange is utilized to achieve long-persistent chemiluminescence imaging and synergistic type-I/II/III photodynamic therapy. As a proof-of-concept, the photosensitizers of carbon nanodots (CDs)-loaded chlorin e6 (CDs-Ce6) are designed and integrated with the peroxalate molecules, and the as-prepare polymer carbon nanodots ( p -CDs) exhibit novel tumor microenvironment (TME)-responsive long-persistent near-infrared CL and photochemical reactions, evoking the in vivo imaging and synergistic dynamic therapy in tumor tissue. Mechanistically, the excess reactive oxygen species in TME can trigger the chemically initiated singlet/triplet electron exchange between the hydrophobic CDs-Ce6 and peroxalate-derived 1,2-dioxetanes and thus the excess excited singlet/triplet electron of the CDs-Ce6 can ensure the long-persistent near-infrared CL, type I/II photochemical production of hydroxyl radicals, superoxide radical and singlet oxygen, and type III photochemical damage of maladjusted biomacromolecules, enabling the long-persistent near-infrared biological imaging and enhanced cancer therapy. These results shed a new sight into the energy transfer mechanism in chemiluminescence and pave a new sight into the architecture of multifunctional theragnostic nanoplatforms.}, archive = {J_ADVS}, author = {Run-Wei Song and Tian-Ci Jiang and Xue-Yang Zhang and Cheng-Long Shen and Qing Lou and Chong-Xin Shan}, doi = {10.1002/advs.202411898}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411898}, shortjournal = {Adv. Sci.}, title = {Triplet electron exchange in carbon nanodots-assisted long-persistent near-infrared chemiluminescence for oncology synergistic imaging and therapy}, volume = {12}, year = {2025}, }
• (2025). Intermittent vibration induces sleep via an allatostatin A-GABA signaling pathway and provides broad benefits in alzheimer's disease models. ADVS, 12(5), 2411768. (www)

  @article{ , abstract = {While animals across species typically experience suppressed consciousness and an increased arousal threshold during sleep, the responsiveness to specific sensory inputs persists. Previous studies have demonstrated that rhythmic and continuous vibration can enhance sleep in both animals and humans. However, the neural circuits underlying vibration-induced sleep (VIS) and its potential therapeutic benefits on neuropathological processes in disease models remain unclear. Here, it is shown that intermittent vibration, such as cycles of 30 s on followed by 30 s off, is more effective in inducing sleep compared to continuous vibration. A clear evidence is further provided that allatostatin A (AstA)-GABA signaling mediates short-term intermittent vibration-induced sleep (iVIS) by inhibiting octopaminergic arousal neurons through activating GABA A receptors. The existence of iVIS in mice is corroborated, implicating the GABAergic system in this process. Finally, intermittent vibration not only enhances sleep but also reduces amyloid-β (Aβ) deposition and reverses memory defects in Alzheimer's disease models. In conclusion, the study defines a central neural circuit involved in mediating short-term iVIS and the potential implications of vibration in treating sleep-related brain disorders.}, archive = {J_ADVS}, author = {Yang Mou and Yan Zhang and Yuxian Zheng and Guang He and Zhi-Xiang Xu and Xiao Xiao and Yong Ping}, doi = {10.1002/advs.202411768}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411768}, shortjournal = {Adv. Sci.}, title = {Intermittent vibration induces sleep via an allatostatin A-GABA signaling pathway and provides broad benefits in alzheimer's disease models}, volume = {12}, year = {2025}, }
• (2025). Sandwich-structured fluorinated polyimide Aerogel/Paraffin phase-change composites simultaneously enables gradient thermal protection and electromagnetic wave transmission. ADVS, 12(5), 2411758. (www)

  @article{ , abstract = {There is an emerging requirement of advanced functional materials for simultaneous thermal protection and electromagnetic wave-transparent transmission applications. A novel polyimide (PI) aerogel-based sandwich-structural composite is developed to meet such a requirement in this study. This composite is based on a unidirectional fluorinated PI (FPI) aerogel as a lower layer, a nondirectional conventional PI aerogel as a middle layer, and a nondirectional FPI aerogel/paraffin phase-change composite as an upper layer. The lower layer exhibits a unique unidirectional porous microstructure and an ultralow dielectric constant of 1.04. The upper layer possesses a dynamical temperature regulation capability thanks to its loaded paraffin having a high latent heat capacity of 242.7 J g −1 . The presence of the nondirectional PI aerogel middle layer can effectively prevent against the leakage of paraffin from the upper layer to the surface of the composite. Through a rational integration of three functional layers, the developed sandwich-structured composite not only can provide gradient thermal protection for hot objects over a long period but also exhibits an excellent wave-transparent capability to establish communication between two electromagnetically shielded electronic devices. With such prominent thermal insulation and wave-transparent functions, the sandwich-structured composite exhibits great potential for specific applications in aircraft, spacecraft, radar systems, and satellite communication.}, archive = {J_ADVS}, author = {Tao Shi and Jianwei Jing and Zhiqiang Qian and Gaojie Wu and Guofeng Tian and Huan Liu and Xiaodong Wang}, doi = {10.1002/advs.202411758}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411758}, shortjournal = {Adv. Sci.}, title = {Sandwich-structured fluorinated polyimide Aerogel/Paraffin phase-change composites simultaneously enables gradient thermal protection and electromagnetic wave transmission}, volume = {12}, year = {2025}, }
• (2025). Dual-enhanced SERS satellite immuno-nanocomplex for multiple PSA-mediated PHI assay toward clinical prostate cancer screening. ADVS, 12(5), 2411747. (www)

  @article{ , abstract = {Prostate specific antigen (PSA) is widely used in liquid biopsy of prostate cancer (PCa) but still faces challenges due to the poor specificity. Herein, this study reports a double-SERS satellite immunoassay, made of an Au–Ag dealloyed intra-nanogap nanoflower (Au–Ag DINF) with strong SERS signals and Au magnetic nanoparticles (AuMNPs) with magnetic capture and SERS amplification, for sensing multiple PSA (free PSA (fPSA), complexed PSA (cPSA) and [-2]proPSA (p2PSA)) toward potential PCa screening. Unlike the previous studies focus on the tPSA and fPSA/tPSA ratio (f/t PSA%), this work introduces a multiple PSA-mediated Prostate Health Index (PHI) assay with significantly increased the predictive accuracy and specificity of PCa, especially the patients with a tPSA level in the “diagnostic gray zone”. Practical analysis of clinical samples demonstrated the SERS immunoassay is capable of identifying the PCa subjects from healthy candidates ( N = 13), and monitoring PCa patients before and after surgery ( N = 5), as well as screening suspicious ones who are in the “gray zone” ( N = 10). Overall, benefiting from the PSA-responsive satellite immuno-nanoassemble strategy, dual-SERS magnification effect, and multiple PSA-based PHI assessment, this proposes bioassay held enormous potential for the early diagnosis, screening, monitoring, and prognosis of PCa.}, archive = {J_ADVS}, author = {Dong Chen and Yilin Ma and Annan Yang and Liping Hu and Hanlin Zhou and Jun Xu and Shanze Chen and Dingmeng Nie and Weifeng Feng and Huaihong Cai and Yanguang Cong and Jiang Pi and Lang Rao and Xueqin Huang and Pinghua Sun and Haibo Zhou}, doi = {10.1002/advs.202411747}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411747}, shortjournal = {Adv. Sci.}, title = {Dual-enhanced SERS satellite immuno-nanocomplex for multiple PSA-mediated PHI assay toward clinical prostate cancer screening}, volume = {12}, year = {2025}, }
• (2025). Avoided crossing phonons realizes high-performance single-crystalline β-Zn4Sb3 thermoelectrics. ADVS, 12(5), 2411498. (www)

  @article{ , abstract = {This study reveals the mechanisms behind the ultralow lattice thermal conductivity κ L in β -Zn 4 Sb 3 single crystals through inelastic neutron scattering (INS). Analyzing phonon behaviors and the interaction between acoustic phonons and rattling modes, the first experimental evidence of avoided crossing in β -Zn 4 Sb 3 is provided. The rattler-phonon avoided crossings contribute to the low κ L in a β -Zn 4 Sb 3 single crystal, enhancing the thermoelectric figure-of-merit ( zT ). TEM characterizations of the β -Zn 4 Sb 3 single crystal with intrinsic and ultralow κ L reveal a grain-boundary-free structure with uniformly dispersed rotation moiré fringes that contribute to low lattice thermal conductivity while maintaining a uniform elemental distribution. Additionally, the significant impact of crystallinity control coupled with dilute doping on boosting thermoelectric performance, with single-crystalline single leg outperforming their polycrystalline counterparts is demonstrated. Notably, the conversion efficiency η of the undoped β -Zn 4 Sb 3 single leg achieves 1.4% under a temperature gradient of 200 K.}, archive = {J_ADVS}, author = {I-Lun Jen and Cheng-Yen Lin and Kuang-Kuo Wang and Chun-Ming Wu and Chi-Hung Lee and Hsin-Jay Wu}, doi = {10.1002/advs.202411498}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411498}, shortjournal = {Adv. Sci.}, title = {Avoided crossing phonons realizes high-performance single-crystalline β-Zn4Sb3 thermoelectrics}, volume = {12}, year = {2025}, }
• (2025). Amplifying and reversing the chiral bias in asymmetric photo-polymerization reaction. ADVS, 12(5), 2411439. (www)

  @article{ , abstract = {Circularly polarized light (CPL) is inherently chiral and is regarded as one possible source for the origin of homochirality. Coincidentally, chiral metal nanoparticles have great prospects in asymmetric photochemical reactions since they can enhance the chiral light-matter interactions. Nonetheless, little is known about how the spin angular momentum of light competes with the chiral electromagnetic field in the vicinity of a chiral nanoparticle during the chiral induction and amplification process. Here, an asymmetric photo-polymerization system is presented where the chiral bias can be selectively regulated by the combination of chiral fields CPL and Ag nanoparticles, either constructively or destructively. Synergistic chiral amplification effect is observed when the handedness of both are matched, while the opposite-handed CPL can overrule the polymer helicity during the chain propagation process when the chiral near-field is weak. There is a bifurcation point in the chiral bias for the orthogonal control of the polymer helicity during the asymmetric photo-polymerization process, favoring for programmable chiroptical micropatterns and multi-channel independent information encoding. This work not only highlights opportunities for selectively regulating the asymmetric photopolymerization but also is highly valuable for fundamental understanding of the symmetry breaking in photochemical reactions.}, archive = {J_ADVS}, author = {Dingdong Liu and Xiangxiang Xu and Zeyu Feng and Chutian Zhang and Jialei Li and Yifan Xie and Jingguo Li and Hongli Zhang and Gang Zou}, doi = {10.1002/advs.202411439}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411439}, shortjournal = {Adv. Sci.}, title = {Amplifying and reversing the chiral bias in asymmetric photo-polymerization reaction}, volume = {12}, year = {2025}, }
• (2025). Ferromagnetic nickel as a sustainable reducing agent for Tin–Lead mixed perovskite in single-junction and tandem solar cells. ADVS, 12(5), 2411403. (www)

  @article{ , abstract = {Narrow-bandgap (NBG) Sn–Pb mixed perovskite solar cells (PSCs) represent a promising solution for surpassing the radiative efficiency of single-junction solar cells. The unique bandgap tunability of halide perovskites enables optimal tandem configurations of wide-bandgap (WBG) and NBG subcells. However, these devices are limited by the susceptibility of Sn 2+ in the NBG bottom cell to being oxidized to Sn 4+ , creating detrimental Sn vacancies. Herein, a novel approach that replaces Sn particles with Ni particles is introduced as the reducing agent for Sn–Pb mixed perovskite precursor solutions. The ferromagnetic properties of Ni enable simple magnetic filtration, eliminating the filtration issues associated with Sn particles. Ni particles can be reused up to five times without significantly affecting the PSC's performance. Additionally, Ni effectively mitigates the oxidation of Sn 2+ due to its low reduction potential (−0.23 V), thereby enhancing device performance. Single-junction Sn–Pb mixed PSCs prepared using Ni achieve a power-conversion efficiency (PCE) of 22.29%, retaining over 90% of their initial efficiency after 1250 h. Furthermore, Ni-based all-perovskite tandem solar cells combining 1.77 eV WBG top cells with 1.25 eV NBG bottom cells achieve a remarkable PCE of 28.13%. Thus, the proposed strategy can facilitate the commercialization of all-perovskite tandem devices.}, archive = {J_ADVS}, author = {Doyun Im and Passarut Boonmongkolras and Yeonghun Yun and Sung Woong Yang and Sunwoo Kim and Jungchul Yun and Rajendra Kumar Gunasekaran and You-Hyun Seo and Nam Joong Jeon and Gill Sang Han and Sangwook Lee}, doi = {10.1002/advs.202411403}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411403}, shortjournal = {Adv. Sci.}, title = {Ferromagnetic nickel as a sustainable reducing agent for Tin–Lead mixed perovskite in single-junction and tandem solar cells}, volume = {12}, year = {2025}, }
• (2025). Current strategies and future directions of wearable biosensors for measuring stress biochemical markers for neuropsychiatric applications. ADVS, 12(5), 2411339. (www)

  @article{ , abstract = {Most wearable biosensors aimed at capturing psychological state target stress biomarkers in the form of physical symptoms that can correlate with dysfunction in the central nervous system (CNS). However, such markers lack the specificity needed for diagnostic or preventative applications. Wearable biochemical sensors (WBSs) have the potential to fill this gap, however, the technology is still in its infancy. Most WBSs proposed thus far target cortisol. Although cortisol detection is demonstrated as a viable method for approximating the extent and severity of psychological stress, the hormone also lacks specificity. Multiplex WBSs that simultaneously target cortisol alongside other viable stress-related biochemical markers (SBMs) can prove to be indispensable for understanding how psychological stress contributes to the pathophysiology of neuropsychiatric illnesses (NPIs) and, thus, lead to the discovery of new biomarkers and more objective clinical tools. However, none target more than one SBM implicated in NPIs. Till this review, cortisol's connection to dysfunctions in the CNS, to other SBMs, and their implication in various NPIs has not been discussed in the context of developing WBS technology. As such, this review is meant to inform the biosensing and neuropsychiatric communities of viable future directions and possible challenges for WBS technology for neuropsychiatric applications.}, archive = {J_ADVS}, author = {Zach Sheffield and Priyanka Paul and Shraddha Krishnakumar and Dipanjan Pan}, doi = {10.1002/advs.202411339}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411339}, shortjournal = {Adv. Sci.}, title = {Current strategies and future directions of wearable biosensors for measuring stress biochemical markers for neuropsychiatric applications}, volume = {12}, year = {2025}, }
• (2025). High spatiotemporal near-infrared II fluorescence lifetime imaging for quantitative detection of clinical tumor margins. ADVS, 12(5), 2411272. (www)

  @article{ , abstract = {Accurate detection of tumor margins is essential for successful cancer surgery. While indocyanine green (ICG)-based near-infrared (NIR) fluorescence (FL) surgical navigation enhances the visual identification of tumor margins, its accuracy remains subjective, underscoring the need for quantitative approaches. In this study, a high spatiotemporal fluorescence lifetime (FLT) imaging technology is developed in the second near-infrared window (NIR-II, 1000–1700 nm) for quantitative tumor margin detection, utilizing folate receptor-targeted ICG nanoprobes (FPH-ICG). FPH-ICG exhibits a significantly prolonged NIR-II FLT (750 ± 7 ps vs 260 ± 3 ps) and increased NIR-II FL brightness (FPH-ICG/ICG = 3.8). In vitro and in vivo studies confirm that FPH-ICG specifically targets folate receptor-α (FRα) on SK-OV-3 ovarian cancer cells, achieving high-contrast NIR-II FL imaging with a signal-to-background ratio of 10.8. Notably, NIR-II FLT imaging demonstrates superior accuracy (90%) and consistency in defining tumor margins compared to NIR-II FL imaging (58%) in both SK-OV-3 tumor-bearing mice and clinical tumor samples. These findings underscore the potential of NIR-II FLT imaging as a quantitative tool for guiding surgical tumor margin detection.}, archive = {J_ADVS}, author = {Zhen Chen and Linjian Huang and Duyang Gao and Zhouzhou Bao and Dehong Hu and Wei Zheng and Jing Chen and Jiuling Liao and Hairong Zheng and Zonghai Sheng}, doi = {10.1002/advs.202411272}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411272}, shortjournal = {Adv. Sci.}, title = {High spatiotemporal near-infrared II fluorescence lifetime imaging for quantitative detection of clinical tumor margins}, volume = {12}, year = {2025}, }
• (2025). Stretchable full-color phosphorescent PVA-based ionogels for multimodal sensing-visual integration applications. ADVS, 12(5), 2411229. (www)

  @article{ , abstract = {Exploring ionogels with superior conductivity, mechanical properties, and long-lasting room temperature phosphorescence (RTP) offers considerable potential for new-generation optoelectronics. However, reports on ionogels remain limited owing to the contradiction between the flexibility required for stretching and the rigidity necessary for RTP and load-bearing within the same ionogels. Here, a facile strategy is reported to enhance the toughness and extend the RTP of ionogels by salting-out-induced microphase separation, which results in the formation of an IL-rich phase (soft) for stretching and ionic conduction and a polymer-rich phase (stiff) for energy dissipation and clustering-triggered phosphorescence. The obtained ionogels exhibit high stretchability (≈400% strain), toughness (≈∼20 MJ m −3 ), ionic conductivity (8.4 mS cm −1 ), and ultralong afterglow lifetime (112.4 ms). This strategy is applicable to chromophores with color-tunable phosphorescence. By leveraging observable full-color RTP and real-time electrical signals in response to diverse stimuli (i.e., stretching and pressing), an intelligent grasping strategy is developed for robust hand pose reconstruction. In addition, a tactile-visual fusion recognition keyboard is created with dual functionality of information encryption and signal transmission. The ease of fabrication, wide tunability, and multifunctionality will help expand the scope of ionogels for smart devices.}, archive = {J_ADVS}, author = {Xuefeng Wei and Zexi Gou and Jianting Ye and L. H. Shi and Jianwei Zhao and Lei Yang and Linbo Zhang and Kun Zhang and Ruonan Jia}, doi = {10.1002/advs.202411229}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411229}, shortjournal = {Adv. Sci.}, title = {Stretchable full-color phosphorescent PVA-based ionogels for multimodal sensing-visual integration applications}, volume = {12}, year = {2025}, }
• (2025). High-entropy Metal–Organic frameworks and their derivatives: Advances in design, synthesis, and applications for catalysis and energy storage. ADVS, 12(5), 2411175. (www)

  @article{ , abstract = {As a nascent class of high-entropy materials (HEMs), high-entropy metal–organic frameworks (HE-MOFs) have garnered significant attention in the fields of catalysis and renewable energy technology owing to their intriguing features, including abundant active sites, stable framework structure, and adjustable chemical properties. This review offers a comprehensive summary of the latest developments in HE-MOFs, focusing on functional design, synthesis strategies, and practical applications. This work begins by presenting the design principles for the synthesis strategies of HE-MOFs, along with a detailed description of commonly employed methods based on existing reports. Subsequently, an elaborate discussion of recent advancements achieved by HE-MOFs in diverse catalytic systems and energy storage technologies is provided. Benefiting from the application of the high-entropy strategy, HE-MOFs, and their derivatives demonstrate exceptional catalytic activity and impressive electrochemical energy storage performance. Finally, this review identifies the prevailing challenges in current HE-MOFs research and proposes corresponding solutions to provide valuable guidance for the future design of advanced HE-MOFs with desired properties.}, archive = {J_ADVS}, author = {Jiangyuan Xing and Yan Liu and George Mathew and Qiu He and Jasmin Aghassi-Hagmann and Simon Schweidler and Ben Breitung}, doi = {10.1002/advs.202411175}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411175}, shortjournal = {Adv. Sci.}, title = {High-entropy Metal–Organic frameworks and their derivatives: Advances in design, synthesis, and applications for catalysis and energy storage}, volume = {12}, year = {2025}, }
• (2025). Biomimic nanodrugs overcome tumor immunosuppressive microenvironment to enhance Cuproptosis/Chemodynamic-induced cancer immunotherapy. ADVS, 12(5), 2411122. (www)

  @article{ , abstract = {Elesclomol (ES) as an efficient Cu ionophore can specifically transport Cu into mitochondria and disrupt intracellular Cu homeostasis. Extra intracellular Cu induces cuproptosis and chemodynamic therapy (CDT), which further cascades immunogenic cell death (ICD) and activates antitumor immune responses. However, the tumor immunosuppressive microenvironment (TIM) attenuates the efficiency of the immune response. Herein, a biomimic nanodrug (ECNM) is fabricated, of which ES, Cu 2+ and NLG919 (an IDO1 inhibitor) are integrated via a self-assembly process and subsequently coated with 4T1 cell membrane. ECNM can overcome the typical drawbacks of ES, ameliorating the stability and half-life of ES by membrane-coating and enhancing its tumor accumulation and internalization via homotypic targeting. It is worth mentioning that, the addition of NLG919 is also beneficial to the system circulation stability of ES and reduces the non-specific ES release. After internalization, ECNM dissociates via the glutathione-responsive process and exhibits comprehensive antitumor capabilities, including cuproptosis, CDT and TIM reversing, thereby eliciting ICD and optimizing the antitumor immune response. Furthermore, ECNM not only accelerates tumor regression but also gains a strong abscopal effect and displays the potential of tumor vaccination. Overall, ECNM can activate antitumor immunity via cuproptosis and CDT, together with TIM reversing, for cancer treatment.}, archive = {J_ADVS}, author = {Hangyi Wu and Xiaoyu Lu and Yuhan Hu and J. Baatarbolat and Zhihao Zhang and Yiping Liang and Youwen Zhang and Ye Liu and Huixia Lv and Xin Jin}, doi = {10.1002/advs.202411122}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2411122}, shortjournal = {Adv. Sci.}, title = {Biomimic nanodrugs overcome tumor immunosuppressive microenvironment to enhance Cuproptosis/Chemodynamic-induced cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Study on recovery strategy of hearing loss & SGN regeneration under physical regulation. ADVS, 12(5), 2410919. (www)

  @article{ , abstract = {The World Health Organization (WHO) reports that by 2050, nearly 2.5 billion people are expected to have some degree of hearing loss (HL) and at least 700 million will need hearing rehabilitation. Therefore, there is an urgent need to develop treatment strategies for HL. At present, the main treatment strategies for HL are hearing aids and cochlear implants (CIs), which cannot achieve a radical cure for HL. Relevant studies have shown that the most fundamental treatment strategy for sensorineural hearing loss (SNHL) is to regenerate hair cells and spiral ganglion neurons (SGNs) through stem cells to repair the structure and function of cochlea. In addition, physical stimulation strategies, such as electricity, light, and magnetism have also been used to promote SGN regeneration. This review systematically introduces the classification, principle and latest progress of the existing hearing treatment strategies and summarizes the advantages and disadvantages of each strategy. The research progress of physical regulation mechanism is discussed in detail. Finally, the problems in HL repair strategies are summarized and the future development direction is prospected, which could provide new ideas and technologies for the optimization of hearing treatment strategies and the research of SGN repair and regeneration through physical regulation.}, archive = {J_ADVS}, author = {Zhe Li and Yijia Gao and Xingyu Chen and Lei Xu and Zhou Li and Renjie Chai}, doi = {10.1002/advs.202410919}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410919}, shortjournal = {Adv. Sci.}, title = {Study on recovery strategy of hearing loss & SGN regeneration under physical regulation}, volume = {12}, year = {2025}, }
• (2025). A lipiodol pickering emulsion stabilized by iron-doped carbon nanozymes for liver transarterial chemoembolization. ADVS, 12(5), 2410873. (www)

  @article{ , abstract = {Transarterial chemoembolization (TACE) utilizing a water-in-oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin-loaded lipiodol emulsion (denoted as ICN-LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron-doped carbon nanozymes (ICN) to mitigate the issue of lipiodol-water separation. This novel emulsion not only solves the instability of conventional lipiodol emulsions, but also facilitates the sustained release of lobaplatin. More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton-like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. By integrating chemotherapy and chemodynamic therapy, ICN-LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN-LPE shows an appealing clinical application prospect for TACE.}, archive = {J_ADVS}, author = {Xiancheng Xia and Yang Li and Rongkang Huang and Yuanbin Wang and Wenxuan Xiong and Hui Zhou and Min Li and Xidong Lin and Youchen Tang and Bo Zhang}, doi = {10.1002/advs.202410873}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410873}, shortjournal = {Adv. Sci.}, title = {A lipiodol pickering emulsion stabilized by iron-doped carbon nanozymes for liver transarterial chemoembolization}, volume = {12}, year = {2025}, }
• (2025). Resensitizing β-lactams by reprogramming purine metabolism in small colony variant for osteomyelitis treatment. ADVS, 12(5), 2410781. (www)

  @article{ , abstract = {Small colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms. In this study, phenotypically stable SCV strains are successfully recovered from clinical specimens, characterized by elevated drug resistance and reduced immunogenicity. Multi-omics analysis revealed that the acquired high drug resistance is associated with altered flux in the purine metabolism pathway, attributable to mutations in the hypoxanthine phosphoribosyltransferase ( hpt ) gene. Furthermore, this study innovatively discovered that lonidamine, an inhibitor of cellular energy metabolism, can effectively mitigate SCV resistance to β-lactam antibiotics, thereby facilitating its eradication. The underlying mechanism involves the reprogramming of purine metabolism. Therefore, a co-delivery system for lonidamine and oxacillin is constructed with amino-modified dendritic mesoporous silica as a carrier, which showed high efficacy and safety in combating SCV both in vitro and in vivo experiments. Overall, this study elucidated the pathogenic mechanisms of a class of clinically isolated SCV isolates with hpt mutations and provided a paradigm for treating SCV-associated osteomyelitis by reprogramming purine metabolism.}, archive = {J_ADVS}, author = {Tingwang Shi and Qiong Wu and Zesong Ruan and Zhiyuan Luo and Wenbo Wang and Zhao Guo and Yihong Ma and Xin Wang and Guangyu Chu and Han Lin and Min Ge and Yunfeng Chen}, doi = {10.1002/advs.202410781}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410781}, shortjournal = {Adv. Sci.}, title = {Resensitizing β-lactams by reprogramming purine metabolism in small colony variant for osteomyelitis treatment}, volume = {12}, year = {2025}, }
• (2025). Neuroligin 1 regulates autistic-like repetitive behavior through modulating the activity of striatal d2 receptor-expressing medium spiny neurons. ADVS, 12(5), 2410728. (www)

  @article{ , abstract = {Restricted and repetitive behavior (RRB) is a primary symptom of autism spectrum disorder (ASD), which poses a significant risk to individuals' health and is becoming increasingly prevalent. However, the specific cellular and neural circuit mechanisms underlying the generation of RRB remain unclear. In this study, it is reported that the absence of the ASD-related protein Neuroligin 1 (NLGN1) in dopamine receptor D2-expressing medium spiny neurons (D2-MSNs) in the dorsal striatum is associated with the duration and frequency of self-grooming and digging behaviors. The Nlgn1 -deficient D2-MSNs are hyperactivated, which correlates with excessive self-grooming and digging behaviors. Inhibiting the activity of D2-MSNs reduces the duration and frequency of these RRBs. Furthermore, it is demonstrated that the generation of self-grooming and digging behaviors depends on distinct patterns of D2-MSN activity. Finally, through single-nucleus RNA sequencing (sn-RNAseq) and protein detection verification, it is revealed that the overactivation of protein kinase C (PKC) in Nlgn1 -deficient mice contributes to excessive repetitive behaviors and increased neuronal excitability. In this study, potential mechanisms are proposed for the generation of self-grooming and digging behaviors, as well as suggest possible treatments and interventions ASD.}, archive = {J_ADVS}, author = {Dandan Lv and An Liu and Ziyue Yi and Mingdao Mu and Miao Wu and Xingcan Li and Kun Cao and Ruining Liu and Zhengping Jia and Junhai Han and Wei Xie}, doi = {10.1002/advs.202410728}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410728}, shortjournal = {Adv. Sci.}, title = {Neuroligin 1 regulates autistic-like repetitive behavior through modulating the activity of striatal d2 receptor-expressing medium spiny neurons}, volume = {12}, year = {2025}, }
• (2025). Dual-modal dielectric elastomer system for simultaneous energy harvesting and actuation. ADVS, 12(5), 2410724. (www)

  @article{ , abstract = {Dielectric elastomers (DEs) have promising capabilities for soft electromechanical systems, including those for actuation and energy generation. However, their widespread application is restricted by electromechanical instability (EMI) and the requirement for high-voltage operation. This study presents a dual-modal DE system that effectively overcomes these limitations by leveraging a dual-membrane structure. The proposed structure not only suppresses EMI through charge sharing but also enables simultaneous energy harvesting and actuation, enhancing the overall electrical performance of the system. The system demonstrated a remarkable improvement in output performance, exceeding that of traditional single-modal DE generators by up to 30%. The practicality of the system is developed by integrating it into a mechanically powered soft robot capable of locomotion and environmental monitoring using a wireless temperature sensor. This study paves the way for the development of advanced DE-based systems with enhanced stability, functionality, and potential for diverse applications in soft robotics, energy harvesting, and other areas that require coupled electromechanical capabilities.}, archive = {J_ADVS}, author = {Zhiyuan Zhang and Wenwei Huang and Shaodi Zheng and Jianbo Tan and Jinzhan Cheng and Jiancheng Cai and Shiju E and Zisheng Xu}, doi = {10.1002/advs.202410724}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410724}, shortjournal = {Adv. Sci.}, title = {Dual-modal dielectric elastomer system for simultaneous energy harvesting and actuation}, volume = {12}, year = {2025}, }
• (2025). Meso hybridized silk fibroin watchband for wearable biopotential sensing and AI gesture signaling. ADVS, 12(5), 2410702. (www)

  @article{ , abstract = {Human biopotential signals, such as electrocardiography, are closely linked to health and chronic conditions. Electromyography, corresponds to muscle actions and is pertinent to human-machine interactions. Here, we present a type of smart and flexible watchband that includes a mini flexible electrode array based on Mo-Au filament mesh, combined with mesoscopic hybridized silk fibroin films. As the layer in contact with the skin, waterborne polyurethane and SF create a highly flexible and permeable meso-hybridized SF/WPU layer, ensuring skin-friendliness and comfortable wearing. The flexible FM electrodes are created by integrating Mo-Au FM into 2D-interconnected networks. Molybdenum filaments provide high rigidity and are coated with Aurum to enhance conductivity. The use of Mo-Au FMs in warp-knitted patterns results in high SNR (43.22 dB), high sensitivity (44.43 mV/kg), and significant motion noise reduction due to the pattern's elastic deformability and skin-gripping properties. Leveraging these unique technologies, these smart watchbands excel in prolonged sensing operation, grasping force detection, and gesture recognition. Through smart raining via deep learning, we achieved an unparalleled recognition rate (96% across 20 volunteers of different genders) among other EMG sensing devices. These results have significant implications for human-machine interaction, including applications in underwater robot control, drone operation, and autonomous vehicle control.}, archive = {J_ADVS}, author = {Xiao Wang and Changsheng Lu and Zerong Jiang and Guangwei Shao and Jingzhe Cao and Xiang Yang Liu}, doi = {10.1002/advs.202410702}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410702}, shortjournal = {Adv. Sci.}, title = {Meso hybridized silk fibroin watchband for wearable biopotential sensing and AI gesture signaling}, volume = {12}, year = {2025}, }
• (2025). Engineering p-orbital states via molecular modules in all-organic electrocatalysts toward direct water oxidation. ADVS, 12(5), 2410507. (www)

  @article{ , abstract = {Oxygen evolution reaction (OER) is an indispensable anode reaction for sustainable hydrogen production from water electrolysis, yet overreliance on metal-based catalysts featured with vibrant d -electrons. It still has notable gap between metal-free and metal-based electrocatalysts, due to lacking accurate and efficient p -band regulation methods on non-metal atoms. Herein, a molecular modularization strategy is proposed for fine-tuning the p -orbital states of series metal-free covalent organic frameworks (COFs) for realizing OER performance beyond benchmark precious metal catalysts. Optimized combination of benzodioxazole/benzodiimide-based building blocks achieves an impressive applied potential of 1.670 ± 0.004 V versus reversible hydrogen electrode (RHE) and 1.735 ± 0.006 V versus RHE to deliver enhanced current densities of 0.5 and 1.0 A cm −2 , respectively. Moreover, it holds a notable charge transfer amount (stands for a long service life) within operation period that outperforms all reported metal-free electrocatalysts. Operando differential electrochemical mass spectrometry (DEMS) with isotope labeling identifies the adsorbate evolution mechanism (AEM). A variety of spectroscopic techniques and density functional theory (DFT) calculations reveal that the p -band center of these catalysts can be shifted stepwise to optimize the oxygen intermediate adsorption and lower the reaction energy barrier. This work provides a novel perspective for enhancing the electrocatalytic performance of metal-free COFs.}, archive = {J_ADVS}, author = {Li-Hong Yu and Xue-Feng Zhang and Zi-Ming Ye and Hong-Gang Du and Li-Dong Wang and Ping-Ping Xu and Yuhai Dou and Li-Ming Cao and Chun-Ting He}, doi = {10.1002/advs.202410507}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410507}, shortjournal = {Adv. Sci.}, title = {Engineering p-orbital states via molecular modules in all-organic electrocatalysts toward direct water oxidation}, volume = {12}, year = {2025}, }
• (2025). Mass-guided single-cell MALDI imaging of low-mass metabolites reveals cellular activation markers. ADVS, 12(5), 2410506. (www)

  @article{ , abstract = {Single-cell MALDI mass spectrometry imaging (MSI) of lipids and metabolites >200 Da has recently come to the forefront of biomedical research and chemical biology. However, cell-targeting and metabolome-preserving methods for analysis of low mass, hydrophilic metabolites (<200 Da) in large cell populations are lacking. Here, the PRISM-MS ( PR escan I maging for S mall M olecule – M ass S pectrometry) mass-guided MSI workflow is presented, which enables space-efficient single cell lipid and metabolite analysis. In conjunction with giant unilamellar vesicles (GUVs) as MSI ground truth for cell-sized objects and Monte Carlo reference-based consensus clustering for data-dependent identification of cell subpopulations, PRISM-MS enables MSI and on-cell MS2-based identification of low-mass metabolites like amino acids or Krebs cycle intermediates involved in stimulus-dependent cell activation. The utility of PRISM-MS is demonstrated through the characterization of complex metabolome changes in lipopolysaccharide (LPS)-stimulated microglial cells and human-induced pluripotent stem cell-derived microglia. Translation of single cell results to endogenous microglia in organotypic hippocampal slice cultures indicates that LPS-activation involves changes of the itaconate-to-taurine ratio and alterations in neuron-to-glia glutamine-glutamate shuttling. The data suggests that PRISM-MS can serve as a standard method in single cell metabolomics, given its capability to characterize larger cell populations and low-mass metabolites.}, archive = {J_ADVS}, author = {James L. Cairns and Johanna Huber and Andrea Lewen and Jessica Jung and Stefan J. Maurer and Tobias Bausbacher and Stefan Schmidt and Pavel A. Levkin and Daniel Sevin and Kerstin Göpfrich and Philipp Koch and Oliver Kann and Carsten Hopf}, doi = {10.1002/advs.202410506}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410506}, shortjournal = {Adv. Sci.}, title = {Mass-guided single-cell MALDI imaging of low-mass metabolites reveals cellular activation markers}, volume = {12}, year = {2025}, }
• (2025). Bacteroides fragilis exacerbates T2D vascular calcification by secreting extracellular vesicles to induce m2 macrophages. ADVS, 12(5), 2410495. (www)

  @article{ , abstract = {Vascular calcification (VC) in type 2 diabetes (T2D) poses a serious threat to the life and health of patients. However, its pathogenesis remains unclear, resulting in a lack of effective treatment for the root cause. It is found that both intestinal Bacteroides fragilis (BF) and peripheral M2 monocytes/macrophages are significantly elevated in patients with T2D VC. M2 macrophages are identified as a significant risk factor for T2D VC. Both BF and their extracellular vesicles (EV) promote T2D VC and facilitate macrophage M2 polarization. Macrophages clearance significantly antagonized BF EV-induced T2D VC in mice. Mechanistically, EV-rich double-stranded DNA (dsDNA) activates stimulator of interferon response cGAMP interactor 1 (Sting), promotes myocyte enhancer factor 2D (Mef2d) phosphorylation, upregulates tribbles pseudokinase 1 (Trib1) expression, and induces macrophage M2 polarization. Concurrently, Mef2d activated by the EV targets and upregulates the expression of pro-calcification factor Serpine1, thereby exacerbating T2D VC. Clinical studies have shown that Serpine1 is significantly elevated in the peripheral blood of patients with T2D VC and is closely associated with T2D VC. In summary, this study reveals that intestinal BF promotes Trib1 expression through the EV-Sting-Mef2d pathway to induce macrophage M2 polarization and upregulates serpin family E member 1 (Serpine1) expression, thereby aggravating T2D VC. The findings provide a new theoretical and experimental bases for optimizing the strategies for prevention and treatment of T2D VC.}, archive = {J_ADVS}, author = {Cong Chen and Zhengfeng Liang and Yuqi He and Yan Gao and Shuhui Ouyang and Lili Wang and Jianghua Liu and Jingsong Cao}, doi = {10.1002/advs.202410495}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410495}, shortjournal = {Adv. Sci.}, title = {Bacteroides fragilis exacerbates T2D vascular calcification by secreting extracellular vesicles to induce m2 macrophages}, volume = {12}, year = {2025}, }
• (2025). Regulation of shade avoidance under low-blue-light by MTA in soybean. ADVS, 12(5), 2410334. (www)

  @article{ , abstract = {Under low blue light (LBL) conditions, soybean exhibits classic shade avoidance syndrome (SAS) with exaggerated stem elongation (ESE), leading to lodging and yield reduction in dense farming. Recently, mRNA modification by N6-methyladenosine (m6A) has emerged as a crucial epigenetic mechanism regulating plant biological processes; however, its impact on shade avoidance remains unexplored. In this study, the double mutants, gmmtas , that are impaired in two m 6 A writer genes, GmMTAa and GmMTAb that encode m 6 A methyltransferases or m 6 A writers are generated. It is found that the gmmtas mutants showed a substantial reduction of m6A levels, a dwarf phenotype, and a diminished sensitivity to LBL. Further investigation of the gmmtas mutants demonstrates that GmMTA regulates shade avoidance response by altering the expression of GmCRY1s , GmSPAs , and GmCOP1s , resulting in increased accumulation of GmSTFs that are known to suppress the shad avoidance response in response to LBL in soybean. The findings reveal a novel molecular mechanism regulating shade resistance in soybean, providing insights into the epigenetic mechanisms of plant adaptation to changing light environments and paving the way for the development of shade-tolerant soybean varieties.}, archive = {J_ADVS}, author = {Liya Zhang and Jun Liu and Jiaqi Chen and Yanyan Zhang and Chao Qin and Xiangguang Lyu and Zhuang Li and Ronghuan Ji and Bin Liu and Hongyu Li and Tao Zhao}, doi = {10.1002/advs.202410334}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410334}, shortjournal = {Adv. Sci.}, title = {Regulation of shade avoidance under low-blue-light by MTA in soybean}, volume = {12}, year = {2025}, }
• (2025). Two birds with one stone: A novel nanocomposite combining silicon nanoparticles and carbon-doped titania as the fluorescence probe and visible light photocatalyst for simultaneous detection and removal of oxytetracycline. ADVS, 12(5), 2410306. (www)

  @article{ , abstract = {The monitoring and removal of environmental pollutants are vital for the sustainable development of society. Herein, a novel nanocomposite combining silicon nanoparticles and carbon-doped titania, C-TiO 2 /SiNPs, is designed as a fluorescence probe and visible-light photocatalyst to simultaneously monitor and degrade oxytetracycline (OTC). C-TiO 2 /SiNPs emit blue fluorescence, which can be quenched by OTC through inner filter effect. Meanwhile, green fluorescence is turned on upon OTC addition by aggregation-induced emission. Thus, C-TiO 2 /SiNPs successfully act as a fluorescence colorimetric probe for quantitation and semi-quantitation of OTC. Additionally, C-TiO 2 /SiNPs show adorable visible-light photocatalytic activity toward OTC, achieving a removal rate of 93.3% in 30 min. This process is driven by the superoxide radicals, holes and hydroxyl radicals produced by C-TiO 2 /SiNPs under visible light irradiation. The total toxicities obviously reduce after OTC is degraded by C-TiO 2 /SiNPs. The concentration during the OTC degradation can be estimated by naked eyes through the change of fluorescence color, but also precisely quantified by a fluorometer. This study innovatively develops a one-stone-two-birds strategy to achieve simultaneous degradation and in situ real-time detection of OTC, paving a promising paradigm for the highly efficient monitoring and removal of residual drugs.}, archive = {J_ADVS}, author = {Liyun Ma and Zhi Li and Yiyi Shi and Yuchen Xie and Ming Jiang and Xu Yu and Li Xu}, doi = {10.1002/advs.202410306}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410306}, shortjournal = {Adv. Sci.}, title = {Two birds with one stone: A novel nanocomposite combining silicon nanoparticles and carbon-doped titania as the fluorescence probe and visible light photocatalyst for simultaneous detection and removal of oxytetracycline}, volume = {12}, year = {2025}, }
• (2025). The critical role of YAP/BMP/ID1 axis on simulated microgravity-induced neural tube defects in human brain organoids. ADVS, 12(5), 2410188. (www)

  @article{ , abstract = {Integrated biochemical and biophysical signals regulate embryonic development. Correct neural tube formation is critical for the development of central nervous system. However, the role of microgravity in neurodevelopment and its underlying molecular mechanisms remain unclear. In this study, the effects of stimulated microgravity (SMG) on the development of human brain organoids are investigated. SMG impairs N-cadherin-based adherens junction formation, leading to neural tube defects associated with dysregulated self-renewal capacity and neuroepithelial disorganization in human brain organoids. Bulk gene expression analyses reveal that SMG alters Hippo and BMP signaling in brain organoids. The neuropathological deficits in SMG-treated organoids can be rescued by regulating YAP/BMP/ID1 axis. Furthermore, sing-cell RNA sequencing data show that SMG results in perturbations in the number and function of neural stem and progenitor cell subpopulations. One of these subpopulations senses SMG cues and transmits BMP signals to the subpopulation responsible for tube morphogenesis, ultimately affecting the proliferating cell population. Finally, SMG intervention leads to persistent neurologic damage even after returning to normal gravity conditions. Collectively, this study reveals molecular and cellular abnormalities associated with SMG during human brain development, providing opportunities for countermeasures to maintain normal neurodevelopment in space.}, archive = {J_ADVS}, author = {Di Guo and Bin Yao and Wen-Wei Shao and Jia-Chen Zuo and Zhe-Han Chang and Jian-Xin Shi and Nan Hu and Shuang-Qing Bao and Meng-Meng Chen and Xiu Fan and Xiao-Hong Li}, doi = {10.1002/advs.202410188}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2410188}, shortjournal = {Adv. Sci.}, title = {The critical role of YAP/BMP/ID1 axis on simulated microgravity-induced neural tube defects in human brain organoids}, volume = {12}, year = {2025}, }
• (2025). All-inorganic perovskite quantum-dot optical neuromorphic synapses for near-sensor colored image recognition. ADVS, 12(5), 2409933. (www)

  @article{ , abstract = {As the demand for the neuromorphic vision system in image recognition experiences rapid growth, it is imperative to develop advanced architectures capable of processing perceived data proximal to sensory terminals. This approach aims to reduce data movement between sensory and computing units, minimizing the need for data transfer and conversion at the sensor-processor interface. Here, an optical neuromorphic synaptic (ONS) device is demonstrated by homogeneously integrating optical-sensing and synaptic functionalities into a unified material platform, constructed exclusively by all-inorganic perovskite CsPbBr 3 quantum dots (QDs). The dual functionality of each unit within the ONS device, which can be operated as either an optical sensor or a synaptic device depending on applied electrical polarity, provides significant advantages over previous heterogeneous integration methods, particularly regarding material selection, structural compatibility, and device fabrication complexity. The ONS device exhibits distinct wavelength responses essential for emulating colored image recognition capability inherent in the human visual system. Additionally, the seamless integration of electronics and photonics within a unified material system establishes a novel paradigm for optical retrieval, enabling real-time perception of the encoded status of the ONS device. These findings represent substantial advancements in near-sensor computing platforms and open a new horizon for all-inorganic perovskite optoelectronic technologies.}, archive = {J_ADVS}, author = {Yung-Chi Yao and Chia-Jung Lee and Yong-Jun Chen and Jun-Zhi Feng and Hongseok Oh and Chin-Shan Lue and Jinn-Kong Sheu and Ya-Ju Lee}, doi = {10.1002/advs.202409933}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409933}, shortjournal = {Adv. Sci.}, title = {All-inorganic perovskite quantum-dot optical neuromorphic synapses for near-sensor colored image recognition}, volume = {12}, year = {2025}, }
• (2025). Molecular understanding of the role of catalyst particle arrangement in local mass transport resistance for fuel cells. ADVS, 12(5), 2409755. (www)

  @article{ , abstract = {Platinum (Pt) catalyst performance loss caused by a high local oxygen transport resistance is an urgent problem to be solved for proton exchange membrane fuel cells (PEMFCs). Rationally arranging Pt particles on carbon support is the primary approach for reducing mass transport resistance. Herein, using a unique method coupling Hybrid Reverse Monte Carlo, molecular dynamics simulations, and experimental measurements, a Pt particle arrangement strategy is proposed to reduce local oxygen transport resistance, based on a molecular-level understanding of its impact. The densely arranged Pt particles with a small interparticle distance lead to the denser ionomer layer due to the co-attraction effect, leading to a high local oxygen transport resistance. The nonuniformly arranged Pt particles with various interparticle distances cause the heterogeneous ionomer density, inducing the heterogeneous oxygen transport. Increasing the Pt-Pt interparticle distance from 2 to 5 nm substantially reduces the local oxygen transport resistance by over 50%. The uniform arrangement of Pt particles makes the ionomer layer density more homogeneous, resulting in more uniform oxygen transport. Therefore, uniformly arranging Pt particles with an interparticle distance of >5 nm on carbon support is preferred for reducing local oxygen transport resistance and improving the homogeneity of oxygen transport.}, archive = {J_ADVS}, author = {Aoxin Ran and Linhao Fan and Chasen Tongsh and Jiaqi Wang and Zhengguo Qin and Qing Du and Meng Ni and Kui Jiao}, doi = {10.1002/advs.202409755}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409755}, shortjournal = {Adv. Sci.}, title = {Molecular understanding of the role of catalyst particle arrangement in local mass transport resistance for fuel cells}, volume = {12}, year = {2025}, }
• (2025). Localized COUP-TFII pDNA delivery modulates Stem/Progenitor cell differentiation to enhance endothelialization and inhibit calcification of decellularized allografts. ADVS, 12(5), 2409744. (www)

  @article{ , abstract = {Decellularized allografts have emerged as promising candidates for vascular bypass grafting, owing to their inherent bioactivity and minimal immunogenicity. However, graft failure that results from suboptimal regeneration and pathological remodeling has hindered their clinical adoption. Recent advances in vascular biology highlight the pivotal role of COUP-TFII in orchestrating endothelial identity, angiogenesis, safeguarding against atherosclerosis, and mitigating vascular calcification. Here, plasmid DNA (pDNA) encoding COUP-TFII is incorporated into decellularized allografts to realize localized delivery. Comprehensive in vitro investigation complemented by a bone marrow transplantation model on genetic-lineage-tracing mouse revealed the underlying mechanisms of COUP-TFII in regulating vascular regeneration and remodeling. COUP-TFII augmented endothelialization and inhibited calcification in decellularized allografts by modulating the Ang1/Tie2/PI3K/AKT signaling pathway that dictates the fate of Sca-1 + stem/progenitor cells. Heparin-polyethyleneimine nanoparticles (HEPI) are prepared as COUP-TFII pDNA nanocarriers (COUP-TFII@HPEI) and used to modify decellularized allografts, achieving long-term and stable overexpression of COUP-TFII. Functionalized grafts are evaluated in rat abdominal artery replacement models, demonstrating enhanced neo-artery regeneration without calcification. The study provides an effective strategy to enhance the applicability of decellularized allograft and illustrates their translational prospects for vascular bypass grafting.}, archive = {J_ADVS}, author = {Mengmeng Xing and Fei Wang and Ruowen Chu and He Wang and Yuyao Sun and Meng Qian and Huan Jiang and Adam C. Midgley and Guohao Dai and Qiang Zhao}, doi = {10.1002/advs.202409744}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409744}, shortjournal = {Adv. Sci.}, title = {Localized COUP-TFII pDNA delivery modulates Stem/Progenitor cell differentiation to enhance endothelialization and inhibit calcification of decellularized allografts}, volume = {12}, year = {2025}, }
• (2025). High-performance pure water-fed anion exchange membrane water electrolysis with patterned membrane via mechanical stress and hydration-mediated patterning technique. ADVS, 12(5), 2409563. (www)

  @article{ , abstract = {Despite rapid advancements in anion exchange membrane water electrolysis (AEMWE) technology, achieving pure water-fed AEMWE remains critical for system simplification and cost reduction. Under pure water-fed conditions, electrochemical reactions occur solely at active sites connected to ionic networks. This study introduces an eco-friendly patterning technique leveraging membrane swelling properties by applying mechanical stress during dehydration under fixed constraints. The method increases active sites by creating additional hydroxide ion pathways at the membrane-electrode interface, eliminating the need for additional ionomers in the electrode. This innovation facilitates ion conduction via locally shortened pathways. Membrane electrode assemblies (MEAs) with patterned commercial membranes demonstrated significantly improved performance and durability compared to MEAs with conventional catalyst-coated substrates and flat membranes under pure water-fed conditions. The universal applicability of this technique was confirmed using in-house fabricated anion exchange membranes, achieving exceptional current densities of 13.7 A cm −2 at 2.0 V in 1.0 M potassium hydroxide (KOH) and 2.8 A cm −2 at 2.0 V in pure water at 60 °C. Furthermore, the scalability of the technique was demonstrated through successful fabrication and operation of large-area cells. These findings highlight the potential of this patterning method to advance AEMWE technology, enabling practical applications under pure water-fed conditions.}, archive = {J_ADVS}, author = {Yeonjae Lee and Sungjun Kim and Yoseph Shin and Yeram Shin and Seongmin Shin and Sanghyeok Lee and Minseop So and Tae-Ho Kim and Sehkyu Park and Jang Yong Lee and Segeun Jang}, doi = {10.1002/advs.202409563}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409563}, shortjournal = {Adv. Sci.}, title = {High-performance pure water-fed anion exchange membrane water electrolysis with patterned membrane via mechanical stress and hydration-mediated patterning technique}, volume = {12}, year = {2025}, }
• (2025). Ethyl lactate ameliorates hepatic steatosis and acute-on-chronic liver injury in alcohol-associated liver disease by inducing fibroblast growth factor 21. ADVS, 12(5), 2409516. (www)

  @article{ , abstract = {Aberrant upregulation of hepatic lipogenesis induced by chronic and excessive alcohol consumption is a critical driver of the progression of alcohol-associated liver disease (ALD), however, no effective approaches inhibiting lipogenesis are currently available for treating ALD patients. Moreover, little is known about whether and how nonethanol ingredients in alcoholic beverages regulate the pathogenesis of ALD. Here the discovery of a small molecule that activates the production and secretion of fibroblast growth factor 21 (FGF21) is reported. It is shown that the activator ethyl lactate, a nonethanol ingredient found in distilled liquors, ameliorates alcoholic hepatosteatosis, inflammation and acute-on-chronic liver injury by stimulating FGF21. In response to chronic-plus-binge ethanol feeding or fasting, ethyl lactate mimics lipogenesis lowering effects by stimulating FGF21 production through the NAD + -dependent deacetylase sirtuin 1 (SIRT1) signaling pathway. These ethyl lactate-mediated beneficial effects are abolished by inhibition of SIRT1 through injection of EX527. Importantly, FGF21 deficiency in hepatocytes blocks the downregulation of lipogenesis by ethyl lactate and exacerbates alcoholic steatosis, inflammation and liver injury. The regulatory mechanism is discussed during the pathophysiological conditions and suggests new lines of research into the therapeutic use of a foodborne small molecule ethyl lactate.}, archive = {J_ADVS}, author = {Yang Jiang and Shuang Wei and Shiming Shen and Yuxiao Liu and Weitong Su and Dong Ding and Zengpeng Zheng and Haokai Yu and Tingting Zhang and Qiuli Yang and Jiuxiang Zhao and Yi Shen and Xia Fang and Liangcai Lin and Dongguang Xiao and Aoyuan Cui and Qin Wan and Yadong Zhang and Yu Li and Cuiying Zhang}, doi = {10.1002/advs.202409516}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409516}, shortjournal = {Adv. Sci.}, title = {Ethyl lactate ameliorates hepatic steatosis and acute-on-chronic liver injury in alcohol-associated liver disease by inducing fibroblast growth factor 21}, volume = {12}, year = {2025}, }
• (2025). Activatable sulfur dioxide nanosonosensitizer enables precisely controllable sono-gaseous checkpoint trimodal therapy for orthotopic hepatocellular carcinoma. ADVS, 12(5), 2409442. (www)

  @article{ , abstract = {Immune checkpoint blockade (ICB) is combined with sonodynamic therapy (SDT) to increase response rates and enhance anticancer efficacy. However, the “always on” property of most sonosensitizers in reducing tumor microenvironment (TME) compromises the therapeutic outcome of sonoimmunotherapy and exacerbates adverse side effects. Precisely controllable strategies combining sulfur dioxide (SO 2 ) gas therapy with cancer immunotherapy can address these issues but remain lacking. Herein an “activatable SO 2 nanosonosensitizer” for precise sono-gaseous checkpoint trimodal therapy of orthotopic hepatocellular carcinoma (HCC) is reported, whose full activity is initiated by ultrasound (US) irradiation in the reducing TME. This “activatable SO 2 nanosonosensitizer,” Aza-DNBS nanoparticles (NPs), are established by self-assembling Aza-boron-dipyrromethene based sonosensitizer molecules and 2,4-dinitrobenzenesulfonate (DNBS)-caged SO 2 prodrug. The activity of Aza-DNBS NPs is initially silenced, and the sonodynamic, gaseous, and immunosuppressive TME reprogramming activities are precisely awakened under US irradiation. Due to the glutathione-responsiveness of Aza-DNBS NPs, Aza-DNBS NPs can generate large amounts of SO 2 for gas therapy-enhanced SDT, which triggers robust immunogenic cell death activation and reprogramming of the immunosuppressive TME, thereby significantly suppressing orthotopic tumor growth and delaying lung metastasis. Thus, this study represents a strategy for designing a generic nanoplatform for precisely combined immunotherapy of orthotopic HCC.}, archive = {J_ADVS}, author = {Jing Liang and Guangwen Cheng and Luping Qiu and Liyun Xue and Huning Xu and Xiaohui Qiao and Na Guo and Huijing Xiang and Yu Chen and Hong Ding}, doi = {10.1002/advs.202409442}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409442}, shortjournal = {Adv. Sci.}, title = {Activatable sulfur dioxide nanosonosensitizer enables precisely controllable sono-gaseous checkpoint trimodal therapy for orthotopic hepatocellular carcinoma}, volume = {12}, year = {2025}, }
• (2025). Probe-based mechanical data storage on polymers made by inverse vulcanization. ADVS, 12(5), 2409438. (www)

  @article{ , abstract = {Big data and artificial intelligence are driving increasing demand for high-density data storage. Probe-based data storage, such as mechanical storage using an atomic force microscope tip, is a potential solution with storage densities exceeding hard disks. However, the storage medium must be modifiable on the nanoscale. While polymers are promising storage media, they face challenges with synthesis, erasing temperatures, and stability. Here, a low-cost and robust polymer system is reported that allows repeated writing, reading and erasing. The polymer is made by inverse vulcanization, providing a network of S─S bonds that can be broken and re-formed repeatedly. This property is leveraged in mechanical indentation to encode information, and thermal S─S metathesis and polymer re-flow to erase. Exquisite control of indentation depth is possible over 1–30 nm. This control enables data encoding not just as a function of the presence or absence of an indent, but also indentation depth. This ternary coding increases the data density four-fold over binary coding. Furthermore, the coding can be done at room temperature which is rare for mechanical information storage. The low cost, ease of synthesis, and dynamic S─S bonds in these polymers are a promising advance in polymer storage media for probe-based data storage.}, archive = {J_ADVS}, author = {Abigail K. Mann and Samuel J. Tonkin and Pankaj Sharma and Christopher T. Gibson and Justin M. Chalker}, doi = {10.1002/advs.202409438}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409438}, shortjournal = {Adv. Sci.}, title = {Probe-based mechanical data storage on polymers made by inverse vulcanization}, volume = {12}, year = {2025}, }
• (2025). In situ transformable nanoparticle effectively suppresses bladder cancer by damaging mitochondria and blocking mitochondrial autophagy flux. ADVS, 12(5), 2409425. (www)

  @article{ , abstract = {Tumor therapeutic strategies based on mitochondrial damage have become an emerging trend. However, the low drug delivery efficiency caused by lysosomal sequestration and the activation of protective mitochondrial autophagy severely restricts the therapeutic efficacy. Herein, an in situ transformable nanoparticle named KCKT is developed to promote lysosomal escape and directly damage mitochondria while blocking mitochondrial autophagy. KCKT exhibits acid responsiveness for precise self-assembly into nanofibers within the lysosomes of cancer cells. The massive accumulation of nanofibers and excessive production of reactive oxygen species (ROS) under sonodynamic therapy synergistically induce lysosomal damage. This facilitates the escape of nanofibers from lysosomal sequestration, thereby enhancing drug delivery. Subsequently, the escaped nanofibers specifically aggregate around the mitochondria for long-term retention and generate ROS under ultrasound irradiation to induce mitochondrial damage. Notably, due to lysosomal dysfunction, damaged mitochondria cannot be cleared by autophagy, further aggravating oxidative damage. These results reveal that KCKT effectively improves drug delivery and mitochondria-targeted therapy efficiency by blocking protective autophagy. These findings hold significant potential for advancing the field of mitochondria-targeted therapy.}, archive = {J_ADVS}, author = {Yulin Lv and Benli Song and Guang Yang and Yuting Wang and Zeyu Wu and Minggui Si and Zongzheng Yang and Huilin Chen and Chen Liu and Min Li and Yinshi Zhang and Zengying Qiao and Lu Wang and Wanhai Xu}, doi = {10.1002/advs.202409425}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409425}, shortjournal = {Adv. Sci.}, title = {In situ transformable nanoparticle effectively suppresses bladder cancer by damaging mitochondria and blocking mitochondrial autophagy flux}, volume = {12}, year = {2025}, }
• (2025). Physical one-way functions for decentralized consensus via proof of physical work. ADVS, 12(5), 2409386. (www)

  @article{ , abstract = {Decentralized consensus on the state of the Bitcoin blockchain is ensured by proof of work. It relies on digital one-way functions and is associated with an enormous environmental impact. This paper conceptualizes a physical one-way function that aims to transform a digital, electricity-consuming consensus mechanism into a physical process. Boundary conditions for the security requirements are established and discussed as well as experimentally investigated for a specific setup based on printing and optical analysis of pigment-carrier composites. In the context of the applied methods, this setup promises to be mathematically unclonable, steady, reproducible, collision resistant and non-invertible and illustrates the feasibility of a physical one-way function. Based on this, a framework for proof of physical work is conceptualized, which has the potential of a drastically lower CO 2 footprint. This work initiates a progressive, interdisciplinary field of research and demands further investigations with regards to alternative setups, security definitions and strategies for challenging them.}, archive = {J_ADVS}, author = {Marvin Winkler and Catharina Peither and Simon Petrick and Lothar Seidemann and Holger Jelich and Frank Kleine Jäger and Jörn Müller-Quade and Alexander Colsmann and Hermann Nirschl and Frank Rhein}, doi = {10.1002/advs.202409386}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409386}, shortjournal = {Adv. Sci.}, title = {Physical one-way functions for decentralized consensus via proof of physical work}, volume = {12}, year = {2025}, }
• (2025). Field-induced antiferromagnetic correlations in a nanopatterned van der waals ferromagnet: A potential artificial spin ice. ADVS, 12(5), 2409240. (www)

  @article{ , abstract = {Nano-patterned magnetic materials have opened new venues for the investigation of strongly correlated phenomena including artificial spin-ice systems, geometric frustration, and magnetic monopoles, for technologically important applications such as reconfigurable ferromagnetism. With the advent of atomically thin 2D van der Waals (vdW) magnets, a pertinent question is whether such compounds could make their way into this realm where interactions can be tailored so that unconventional states of matter can be assessed. Here, it is shown that square islands of CrGeTe 3 vdW ferromagnets distributed in a grid manifest antiferromagnetic correlations, essential to enable frustration resulting in an artificial spin-ice. By using a combination of SQUID-on-tip microscopy, focused ion beam lithography, and atomistic spin dynamic simulations, it is shown that a square array of CGT island as small as 150 × 150 × 60 nm 3 have tunable dipole–dipole interactions, which can be precisely controlled by their lateral spacing. There is a crossover between non-interacting islands and significant inter-island anticorrelation depending on how they are spatially distributed allowing the creation of complex magnetic patterns not observable at the isolated flakes. These findings suggest that the cross-talk between the nano-patterned magnets can be explored in the generation of even more complex spin configurations where exotic interactions may be manipulated in an unprecedented way.}, archive = {J_ADVS}, author = {Avia Noah and Nofar Fridman and Yishay Zur and Maya Markman and Yotam Katz King and Maya Klang and Ricardo Rama-Eiroa and Harshvardhan Solanki and Michael L. Reichenberg Ashby and Tamar Levin and Edwin Herrera and Martin E. Huber and Snir Gazit and Elton J. G. Santos and Hermann Suderow and Hadar Steinberg and Oded Millo and Yonathan Anahory}, doi = {10.1002/advs.202409240}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409240}, shortjournal = {Adv. Sci.}, title = {Field-induced antiferromagnetic correlations in a nanopatterned van der waals ferromagnet: A potential artificial spin ice}, volume = {12}, year = {2025}, }
• (2025). BRD8 guards the pluripotent state by sensing and maintaining histone acetylation. ADVS, 12(5), 2409160. (www)

  @article{ , abstract = {Epigenetic control of cell fates is a critical determinant to maintain cell type stability and permit differentiation during embryonic development. However, the epigenetic control mechanisms are not well understood. Here, it is shown that the histone acetyltransferase reader protein BRD8 impairs the conversion of primed mouse EpiSCs (epiblast stem cells) to naive mouse ESCs (embryonic stem cells). BRD8 works by maintaining histone acetylation on promoters and transcribed gene bodies. BRD8 is responsible for maintaining open chromatin at somatic genes, and histone acetylation at naive-specific genes. When Brd8 expression is reduced, chromatin accessibility is unchanged at primed-specific genes, but histone acetylation is reduced. Conversely, naive-specific genes has reduced repressive chromatin marks and acquired accessible chromatin more rapidly during the cell type conversion. It is shown that this process requires active histone deacetylation to promote the conversion of primed to naive. This data supports a model for BRD8 reading histone acetylation to accurately localize the genome-wide binding of the histone acetyltransferase KAT5. Overall, this study shows how the reading of the histone acetylation state by BRD8 maintains cell type stability and both enables and impairs stem cell differentiation.}, archive = {J_ADVS}, author = {Li Sun and Xiuling Fu and Zhen Xiao and Gang Ma and Yibin Zhou and Haoqing Hu and Liyang Shi and Dongwei Li and Ralf Jauch and Andrew Paul Hutchins}, doi = {10.1002/advs.202409160}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409160}, shortjournal = {Adv. Sci.}, title = {BRD8 guards the pluripotent state by sensing and maintaining histone acetylation}, volume = {12}, year = {2025}, }
• (2025). Triggering oxygen redox cycles in nickel ferrite by octahedral geometry engineering for enhancing oxygen evolution. ADVS, 12(5), 2409024. (www)

  @article{ , abstract = {Spinel-type nickel ferrite (Ni x Fe 3-x O 4 , x≤1) is a widely used electrocatalyst for the oxygen evolution reaction (OER). Due to the lower hybridization of metal- d and oxygen- p orbitals, the OER process on Ni x Fe 3-x O 4 follows the sluggish adsorbate evolution mechanism (AEM). Generally, activating the lattice oxygen to trigger the lattice-oxygen-mediated mechanism (LOM) can enhance the OER activity. Herein, to trigger the LOM pathway while maintaining high stability, iron foam (IF)-supported Ni 0.75 Fe 2.25 O 4 (NiFeO) with geometrical defects of [NiO 6 ] (nickel cation coordinated with six oxygen anions) units and higher ratio of Fe to Ni cations in octahedral sites ( d -NiFe HR O/IF) is prepared by ion-exchanging with polar aprotic solvent followed by annealing. As a result, as-synthesized d -NiFe HR O/IF exhibits excellent activity (at 295 mV overpotential to achieve 100 mA cm −2 ), fast kinetics (Tafel slope of only 34.6 mV dec −1 ), and high stability (maintaining a current density of 100 mA cm −2 over 130 h) for the OER. The theoretical calculations reveal that the construction of octahedral defect in Ni x Fe 3-x O 4 enhances the overlap of Fe- d and O- p orbitals, which can activate the lattice oxygen. Therefore, increasing the ratio of Fe to Ni will further improve the lattice oxygen redox activity, and thus trigger the fast LOM pathway, ultimately facilitating the OER process.}, archive = {J_ADVS}, author = {Yang Peng and Xu Zhao and Yiqun Shao and Xin Yue and Zhuofeng Hu and Shaoming Huang}, doi = {10.1002/advs.202409024}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2409024}, shortjournal = {Adv. Sci.}, title = {Triggering oxygen redox cycles in nickel ferrite by octahedral geometry engineering for enhancing oxygen evolution}, volume = {12}, year = {2025}, }
• (2025). Hepatic steatosis aggravates vascular calcification via extracellular vesicle-mediated osteochondrogenic switch of vascular smooth muscle cells. ADVS, 12(5), 2408660. (www)

  @article{ , abstract = {The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has risen sharply. This condition is strongly associated with the risk of cardiovascular disease (CVD), but how MAFLD affects the development and progression of CVD, particularly concerning vascular calcification, remains unclear. Herein, extracellular vesicles (EVs) are identified from steatotic hepatocytes as a trigger that accelerated the progression of both vascular intimal and medial calcification. Steatotic hepatocytes are found to release more EVs, which are able to reach the vascular tissue, be taken up by vascular smooth muscle cells (VSMCs), and promote their osteogenic differentiation. Within these toxic vesicles, a protein cargo is identified called lectin galactoside-binding soluble 3 binding protein (Lgals3bp) that acted as a potent inducer of osteochondrogenic transformation in VSMCs. Both the inhibition of EV release and the liver-specific knockdown of Lgals3bp profoundly attenuated vascular calcification. This work partially explains the reason for the high incidence of vascular calcification in MAFLD and unveils a novel mechanism that may be used to prevent or treat cardiovascular complications in patients with MAFLD.}, archive = {J_ADVS}, author = {Zhao-Lin Zeng and Zhi-Bo Zhao and Qing Yuan and Shi-Qi Yang and Zhen-Xing Wang and Zuo Wang and Shi-Yu Zeng and An-Qi Li and Qian Chen and Guo-Qiang Zhu and Xin-Hua Xiao and Guang-Hua Luo and Hai-Yan Luo and Jiao-Yang Li and Xu-Yu Zu and Hui Xie and Jiang-Hua Liu}, doi = {10.1002/advs.202408660}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2408660}, shortjournal = {Adv. Sci.}, title = {Hepatic steatosis aggravates vascular calcification via extracellular vesicle-mediated osteochondrogenic switch of vascular smooth muscle cells}, volume = {12}, year = {2025}, }
• (2025). Enhanced oxidative phosphorylation driven by TACO1 mitochondrial translocation promotes stemness and cisplatin resistance in bladder cancer. ADVS, 12(5), 2408599. (www)

  @article{ , abstract = {Chemoresistance poses a critical obstacle in bladder cancer (BCa) treatment, and effective interventions are currently limited. Elevated oxidative phosphorylation (OXPHOS) has been linked to cancer stemness, a determinant of chemoresistance. However, the mechanisms underlying increased OXPHOS during cancer cell chemoresistance remain unclear. This study revealed that the mitochondrial translational activator of cytochrome oxidase subunit 1 (TACO1) is linked to stemness and cisplatin resistance in BCa cells. Mechanistically, mitochondrial TACO1 enhances the translation of the mitochondrial cytochrome c oxidase I (MTCO1), promoting mitochondrial reactive oxygen species (mtROS) by upregulating OXPHOS, consequently driving cancer stemness and cisplatin resistance. Intriguingly, the mitochondrial translocation of TACO1 is mediated by the heat shock protein 90 β (HSP90β), a process that requires circFOXK2 as a scaffold for the TACO1-HSP90β interaction. The mutations at the binding sites of TACO1-circFOXK2-HSP90β disturb the ternary complex and inhibit cancer stemness and cisplatin resistance in BCa cells by suppressing the MTCO1/OXPHOS/mtROS axis. Clinically, BCa patients with increased mitochondrial TACO1 expression respond poorly to cisplatin treatment. This study elucidates the mechanisms by which TACO1 promotes BCa stemness and cisplatin resistance, providing a potential target for mitigating cisplatin resistance for BCa and a biomarker for predicting cisplatin response.}, archive = {J_ADVS}, author = {Minhua Deng and Zhaohui Zhou and Jiawei Chen and Xiangdong Li and Zefu Liu and Jingwei Ye and Wensu Wei and Ning Wang and Yulu Peng and Xin Luo and Lijuan Jiang and Fangjian Zhou and Xianchong Zheng and Zhuowei Liu}, doi = {10.1002/advs.202408599}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2408599}, shortjournal = {Adv. Sci.}, title = {Enhanced oxidative phosphorylation driven by TACO1 mitochondrial translocation promotes stemness and cisplatin resistance in bladder cancer}, volume = {12}, year = {2025}, }
• (2025). Highly sensitive in vivo imaging of bacterial infections with a hydrophilicity-switching, self-immobilizing, near-infrared fluorogenic β-lactamase probe enriched within bacteria. ADVS, 12(5), 2408559. (www)

  @article{ , abstract = {The emergence of antibiotic resistance, particularly bacterial resistance to β-lactam antibiotics, the most widely prescribed therapeutic agents for infectious diseases, poses a significant threat to public health worldwide. The discovery of effective therapies against antibiotic-resistant pathogens has become an urgent need, necessitating innovative approaches to accelerate the identification and development of novel antibacterial agents. On the other hand, the expression of the β-lactam-hydrolyzing enzyme (β-lactamase), the major cause of bacterial resistance to β-lactam antibiotics, provides a distinctive opportunity to visualize bacterial infection, evaluate the efficacy of existing antibiotics, screen for novel antibacterial agents, and optimize drug dosing regimens in live animals. Herein, a hydrophilicity-switching, self-immobilizing, near-Infrared fluorogenic β-lactamase probe for the highly sensitive imaging of bacterial infection in live mice is reported. This probe, in addition to a significant increase in fluorescence upon selective hydrolysis by β-lactamases as conventional β-lactamase probes, also massively enriches within β-lactamase-expressing bacteria (over 1500-folds compared to the incubation medium), which renders excellent sensitivity in the imaging of bacterial infections in living animals. This agent has proven to enable the assessment of antibiotic therapeutic efficacy and potency of β-lactamase inhibitors in living animals in a non-invasive and much more convenient manner.}, archive = {J_ADVS}, author = {Fangfang Chen and Yuyao Li and Yan Peng and Yifan Zhu and Gao He and Zhengwei Zhang and Hexin Xie}, doi = {10.1002/advs.202408559}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2408559}, shortjournal = {Adv. Sci.}, title = {Highly sensitive in vivo imaging of bacterial infections with a hydrophilicity-switching, self-immobilizing, near-infrared fluorogenic β-lactamase probe enriched within bacteria}, volume = {12}, year = {2025}, }
• (2025). Chirality evolution of supramolecular helices by electron transfer assisted secondary nucleation. ADVS, 12(5), 2408499. (www)

  @article{ , abstract = {Chirality evolution is ubiquitous and important in nature, but achieving it in artificial systems is still challenging. Herein, the chirality evolution of supramolecular helices based on l -phenylalanine derivative (LPF) and naphthylamide derivate (NDIAPY) is achieved by the strategy of electron transfer (ET) assisted secondary nucleation. ET from LPF to NDIAPY can be triggered by 5 s UV irradiation on left-handed LPF-NDIAPY co-assemblies, leading to NDIAPY radical anions and partial disassembly of the helices. Meanwhile, spontaneous reversion of radical anions into monomers occurs upon removal of UV light, and the surface of residual co-assemblies can accelerate the reversion process. This surface accelerated reversion of ET further facilitates the secondary nucleation-elongation events, giving rise to the formation of scale-amplified and g vale-increased left-handed helices. Meanwhile, chirality evolution controlled by ET assisted secondary nucleation process can be also realized by adding the prepared LPF-NDIAPY co-assemblies into the total ET system. This study may provide a useful approach to constructing and modulating diverse chiral structures by manipulating the secondary nucleation process.}, archive = {J_ADVS}, author = {Laiben Gao and Xiaoqiu Dou and Chao Xing and Kaikai Yang and Changli Zhao and Chuanliang Feng}, doi = {10.1002/advs.202408499}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2408499}, shortjournal = {Adv. Sci.}, title = {Chirality evolution of supramolecular helices by electron transfer assisted secondary nucleation}, volume = {12}, year = {2025}, }
• (2025). Sequential release HydroLipo system for STING gene epigenetic reprogramming and immune activation in glioblastoma. ADVS, 12(5), 2408323. (www)

  @article{ , abstract = {Glioblastoma (GBM) remains a daunting oncological challenge because of its aggressive nature and resistance to conventional therapies. Inhibition of the intrinsic STING pathway in GBM hampers the effectiveness of immunotherapies. To overcome this clinical limitation, a Sequential Release HydroLipo System (SRHLS) is developed, in which hydrogels and nanoparticles are combined for controlled drug release. The SRHLS sequentially released decitabine and STING agonists, thereby correcting STING signaling dysfunction through epigenetic reprogramming and enhancing antitumor immunity. According to in vitro and in vivo experiments, the SRHLS reshaped the tumor microenvironment and markedly inhibited tumor growth, recurrence, and metastasis. These findings underscore the potential of the SRHLS as a promising therapeutic strategy for GBM.}, archive = {J_ADVS}, author = {Hao Yu and Wenjing Liu and Kaikai Ding and Jiangjie Wu and Cheng Wang and Siyuan Wang and Lingyun Wu and Qiuying Tang and Xin Yin and Kan Jiang and Danfang Yan and Xu Wang and Si Chen and Senxiang Yan}, doi = {10.1002/advs.202408323}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2408323}, shortjournal = {Adv. Sci.}, title = {Sequential release HydroLipo system for STING gene epigenetic reprogramming and immune activation in glioblastoma}, volume = {12}, year = {2025}, }
• (2025). Research on fine-grained phenotypic analysis of temporal root systems – Improved YoloV8seg applied for fine-grained analysis of in situ root temporal phenotypes. ADVS, 12(5), 2408144. (www)

  @article{ , abstract = {Root systems are crucial organs for crops to absorb water and nutrients. Conducting phenotypic analysis on roots is of great importance. To date, methods for root system phenotypic analysis have predominantly focused on semantic segmentation, integrating phenotypic extraction software to achieve comprehensive root phenotype analysis. This study demonstrates the feasibility of instance segmentation tasks on in situ root system images. An improved YoloV8n-seg network tailored for detecting elongated roots is proposed, which outperforms the original YoloV8seg in all network performance metrics. Additionally, the post-processing method introduced reduces root identification errors, ensuring a one-to-one correspondence between each root system and its detection box. The experiment yields phenotypic parameters for fine-grained roots, such as fine-grained root length, diameter, and curvature. Compared to traditional parameters like total root length and average root diameter, these detailed phenotypic analyses enable more precise phenotyping and facilitate accurate artificial intervention during crop cultivation.}, archive = {J_ADVS}, author = {Qiushi Yu and Meng Zhang and Liuli Wang and Xingyun Liu and Lingxiao Zhu and Liantao Liu and Nan Wang}, doi = {10.1002/advs.202408144}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2408144}, shortjournal = {Adv. Sci.}, title = {Research on fine-grained phenotypic analysis of temporal root systems – Improved YoloV8seg applied for fine-grained analysis of in situ root temporal phenotypes}, volume = {12}, year = {2025}, }
• (2025). Unveiling tissue-specific RNA landscapes in mouse organs during fasting and feeding using nanopore direct RNA sequencing. ADVS, 12(5), 2408054. (www)

  @article{ , abstract = {Understanding tissue-specific RNA landscapes is essential for uncovering the functional mechanisms of key organs in mammals. However, current knowledge remains limited, as short-read RNA sequencing—the predominant method for assessing gene expression—depends on incomplete gene annotations and struggles to resolve the diverse transcripts produced by genes. To address these limitations, an integrative approach combining nanopore direct RNA sequencing (DRS), ATAC-Seq, and short-read RNA-seq is used. This method enabled the analysis of RNA landscapes across major mouse organs under fasting and fed conditions, representing two extremes of the caloric cycle. This study uncovered tens of thousands of novel transcripts and identified hundreds of genes with tissue-specific expression, revealing additional layers of regulated pathways within each organ that conventional short-read RNA-seq cannot resolve. By profiling transcript expression across multiple organs under identical conditions, it is conducted comparative analyses exposing significant differences in transcript isoforms and regulations. Moreover, nanopore DRS revealed dynamic changes in poly(A) tail length and m6A modifications of transcripts, many regulated in a tissue-specific manner. These changes likely contribute to functional differentiation and metabolic specialization of various organs. Collectively, this findings reveal previously unrecognized layers of gene regulation, offering new insights into the metabolic basis of organ function.}, archive = {J_ADVS}, author = {Chengfei Jiang and Ping Li and Haiming Cao}, doi = {10.1002/advs.202408054}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2408054}, shortjournal = {Adv. Sci.}, title = {Unveiling tissue-specific RNA landscapes in mouse organs during fasting and feeding using nanopore direct RNA sequencing}, volume = {12}, year = {2025}, }
• (2025). Noncontact monitoring and imaging of the operation and performance of thin-film field-effect transistors. ADVS, 12(5), 2407923. (www)

  @article{ , abstract = {In this study, the first noncontact and non-destructive methodology is developed for monitoring and imaging the operation and performance of thin-film field-effect transistors (TFTs) using second-harmonic generation (SHG) imaging. By analyzing the SHG signal intensity, which is directly related to the electric field at the interface between the semiconductor channel and gate insulator, critical electrical parameters such as the threshold voltage (V TH ) and flat-band voltage (V FB ) are successfully determined. These findings demonstrate a strong correlation between SHG signals and V TH and V FB in InGaZnO TFTs under various process conditions. Notably, the method achieves an unprecedented resolution of ΔV FB below 100 mV in assessing electrical properties through SHG measurements, surpassing conventional spectroscopy techniques. Furthermore, a system is developed to monitor and image the TFT array operation and performance, enabling us to distinguish between pass and fail devices and measure the V TH distribution based on the SHG intensity. This approach facilitates early failure detection and supports efficient curing during manufacturing, thereby marking significant advancements in TFT technology and quality control processes.}, archive = {J_ADVS}, author = {Kwangsik Jeong and Dong yeob Shin and Ji-Min Park and Dong-Joon Yi and Hyunmin Hong and Hyun-Suk Kim and Kwun-Bum Chung}, doi = {10.1002/advs.202407923}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407923}, shortjournal = {Adv. Sci.}, title = {Noncontact monitoring and imaging of the operation and performance of thin-film field-effect transistors}, volume = {12}, year = {2025}, }
• (2025). PNPO-mediated oxidation of DVL3 promotes multiple myeloma malignancy and osteoclastogenesis by activating the wnt/β-catenin pathway. ADVS, 12(5), 2407681. (www)

  @article{ , abstract = {Multiple myeloma (MM) is a cancer of plasma cells caused by abnormal gene expression and interactions within the bone marrow (BM) niche. The BM environment significantly influences the progression of MM. Celastrol, a natural compound derived from traditional Chinese medicine, exhibits significant anticancer effects. This study aimed to identify specific targets of celastrol and develop more effective and less toxic treatment options for MM. Celastrol is used as a probe to determine its specific target, pyridoxine-5′-phosphate oxidase (PNPO). Increased levels of PNPO are associated with poor outcomes in MM patients, and PNPO promotes MM cell proliferation and induces osteoclast differentiation through exosomes. Mechanistically, PNPO oxidizes disheveled 3 M282 (DVL3), leading to abnormal activation of the Wnt/β-catenin pathway. Based on the critical sites of PNPO R95/K117 , Eltrombopag is identified as a potential therapeutic candidate for MM. In addition, the experiments showed its efficacy in mouse models. Eltrombopag inhibited the growth of MM cells and reduced bone lesions by disrupting the interaction between PNPO and DVL3, as supported by preliminary clinical trials. The study highlights the importance of PNPO as a high-risk gene in the development of MM and suggests that Eltrombopag may be a promising treatment option.}, archive = {J_ADVS}, author = {Zhendong Deng and Shanliang Sun and Nian Zhou and Yumeng Peng and Long Cheng and Xichao Yu and Yuxia Yuan and Mengjie Guo and Min Xu and Yuexin Cheng and Fan Zhou and Nianguang Li and Ye Yang and Chunyan Gu}, doi = {10.1002/advs.202407681}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407681}, shortjournal = {Adv. Sci.}, title = {PNPO-mediated oxidation of DVL3 promotes multiple myeloma malignancy and osteoclastogenesis by activating the wnt/β-catenin pathway}, volume = {12}, year = {2025}, }
• (2025). Cis-regulation of an m6A eraser by an insertion variant associated with survival of patients with non-small cell lung carcinoma. ADVS, 12(5), 2407652. (www)

  @article{ , abstract = {N6-methyladenosine (m 6 A) serves as one of the crucial RNA modifications for genes involved in cancer progression. Here, 7273 expression quantitative trait loci potentially regulating 30 m6A pathway genes are identified from the GTEx database, with 69 single nucleotide polymorphisms significantly associated with survival of non-small cell lung carcinoma (NSCLC) patients ( n = 1523) from the ongoing genome-wide association study after false positive probability tests. Notably, the rs151198415 locus, situated in a potential enhancer region, demonstrated a prolonged survival effect with the C>CCACG insertion, which is validated in an independent prospective cohort ( n = 237), yielding a pooled hazard ratio of 0.72 ( p = 0.007). Mechanistically, the rs151198415 C>CCACG insertion engaged in long-range interaction with the promoter of m 6 A eraser ALKBH5 , promoting ALKBH5 transcription by the creation of an EGR1 binding site. Then, ALKBH5 upregulated FBXL5 expression by m 6 A demethylation, which is dependent on the ALKBH5 H204 amino acid site and specific m 6 A sites on FBXL5 mRNA. Finally, the ALKBH5-FBXL5 axis reduces intracellular reactive oxygen species levels, leading to PI3K/AKT and NF-kB pathway inhibition and consequently suppresses NSCLC proliferation and metastasis in vitro and in vivo. Triggered by an insertion variant, this remote cis-regulation of m 6 A eraser and the downstream molecular events modulate the survival of NSCLC patients.}, archive = {J_ADVS}, author = {Lei Cheng and Qiangsheng Hu and Yanan Wang and Wei Nie and Haijiao Lu and Bo Zhang and Genming Zhao and Shiyun Ding and Feng Pan and Yinchen Shen and Runbo Zhong and Ruoxin Zhang}, doi = {10.1002/advs.202407652}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407652}, shortjournal = {Adv. Sci.}, title = {Cis-regulation of an m6A eraser by an insertion variant associated with survival of patients with non-small cell lung carcinoma}, volume = {12}, year = {2025}, }
• (2025). Ultrasound-activated precise sono-immunotherapy for breast cancer with reduced pulmonary fibrosis. ADVS, 12(5), 2407609. (www)

  @article{ , abstract = {Immune checkpoint inhibitors have demonstrated remarkable efficacy across various cancer types. However, immune-related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as the primary adverse reaction, which can lead to irreversible pulmonary fibrosis. Additionally, monotherapy with programmed death ligand (PD-L1) inhibitors has shown limited effectiveness. Therefore, to improve the response rate of immunotherapy and reduce pulmonary fibrosis, this study designed and prepared an intelligent nanodrug based on dendritic mesoporous silica nanoparticles (DMSNs) loaded with a sono-sensitive agent protoporphyrin IX (PpIX). Additionally, a reactive oxygen species (ROS) sensitive linker is used to attach the immunotherapeutic drug PD-L1 inhibitor (aPD-L1) to DMSNs via covalent bonds. The external ultrasound (US) activates PpIX to generate ROS, which breaks the linker to release aPD-L1 to induce sonodynamic therapy (SDT) and immunotherapy. This sono-immnotherapy approach demonstrated excellent outcomes in tumor inhibition, eliciting immune responses, and reducing pulmonary fibrosis. Overall, this study offers a new, efficient, and safe method for breast cancer treatment, and expands the application of immunotherapy.}, archive = {J_ADVS}, author = {Xiang Li and Gao He and Hui Jin and Xinyu Xiang and Dong Li and Renmiao Peng and Jing Tao and Xinping Li and Kaiyang Wang and Yu Luo and Xiaoan Liu}, doi = {10.1002/advs.202407609}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407609}, shortjournal = {Adv. Sci.}, title = {Ultrasound-activated precise sono-immunotherapy for breast cancer with reduced pulmonary fibrosis}, volume = {12}, year = {2025}, }
• (2025). Quaternized molecular brush-grafted injectable microgel with anti-inflammatory and drainage properties for efficient therapy of anal fistula. ADVS, 12(5), 2407537. (www)

  @article{ , abstract = {Anal fistula is a common disease with recurrent inflammation and accumulated exudate. Traditional treatments often fail to effectively eliminate inflammation and ensure adequate drainage, leading to prolonged healing time and a high recurrence rate. Herein, a new class of quaternized molecular brush-grafted injectable microgel (denoted as GAA@CNT- g -PVBTMA) is developed through thermal polymerization and mechanical fragmentation to promote the healing process of anal fistula. Benefiting from the fragmented morphology with a porous structure, the microgel can effectively fill the fistula and facilitate the drainage of exudate. Owing to the electrostatic interactions between the positively charged quaternized carbon nanotube molecular brush (CNT- g -PVBTMA) and the negatively charged inflammatory cytokines, GAA@CNT- g -PVBTMA microgel exhibits excellent anti-inflammatory properties with scavenging rates of 92.6% for tumor necrosis factor-α (TNF-α) and 92.5% for interleukin-1β (IL-1β). Rat inflammatory anal fistula model demonstrates that the microgel can effectively reduce inflammation and epithelialization of the fistula, thereby promoting the healing of the anal fistula. By integrating effective filling, adequate drainage, and excellent anti-inflammatory properties, GAA@CNT- g -PVBTMA microgel provides a promising new direction for the treatment of anal fistula.}, archive = {J_ADVS}, author = {Runxian Wang and Pengwei Ma and Siqi He and Xiao Wang and Jinquan Zhang and Junwen Ye and Mingli Su and Xingxing Shi and Ruoxu Dou}, doi = {10.1002/advs.202407537}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407537}, shortjournal = {Adv. Sci.}, title = {Quaternized molecular brush-grafted injectable microgel with anti-inflammatory and drainage properties for efficient therapy of anal fistula}, volume = {12}, year = {2025}, }
• (2025). TEAD1-mediated trans-differentiation of vascular smooth muscle cells into fibroblast-like cells contributes to the stabilization and repair of disrupted atherosclerotic plaques. ADVS, 12(5), 2407408. (www)

  @article{ , abstract = {Atherosclerotic plaque rupture mainly contributes to acute coronary syndrome (ACS). Insufficient repair of these plaques leads to thrombosis and subsequent ACS. Central to this process is the modulation of vascular smooth muscle cells (VSMCs) phenotypes, emphasizing their pivotal role in atherosclerotic plaque stability and healing post-disruption. Here, an expansion of FSP1 + cells in a tandem stenosis (TS) model of atherosclerotic mice is unveiled, predominantly originating from VSMCs through single-cell RNA sequencing (scRNA-seq) analyses and VSMC lineage tracing studies. Further investigation identified TEA domain transcription factor 1 (TEAD1) as the key transcription factor driving the trans-differentiation of VSMCs into fibroblast-like cells. In vivo experiments using a TS model of plaque rupture demonstrated that TEAD1 played a crucial role in promoting plaque stability and healing post-rupture through pharmacological or TEAD1-AAV treatments. Mechanistically, it is found that TEAD1 promoted the expression of fibroblast markers through the Wnt4/β-Catenin pathway, facilitating the trans-differentiation. Thus, this study illustrated that TEAD1 played a critical role in promoting the trans-differentiation of VSMCs into fibroblast-like cells and subsequent extracellular matrix production through the Wnt4/β-Catenin pathway. Consequently, this process enhanced the healing mechanisms following plaque rupture, elucidating potential therapeutic avenues for managing atherosclerotic instability.}, archive = {J_ADVS}, author = {Ming Zhai and Zhijun Lei and Yefei Shi and Jiayun Shi and Yanxi Zeng and Shiyu Gong and Weixia Jian and Jianhui Zhuang and Qing Yu and Mark W. Feinberg and Wenhui Peng}, doi = {10.1002/advs.202407408}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407408}, shortjournal = {Adv. Sci.}, title = {TEAD1-mediated trans-differentiation of vascular smooth muscle cells into fibroblast-like cells contributes to the stabilization and repair of disrupted atherosclerotic plaques}, volume = {12}, year = {2025}, }
• (2025). MAM-STAT3-driven mitochondrial ca+2 upregulation contributes to immunosenescence in type a mandibuloacral dysplasia patients. ADVS, 12(5), 2407398. (www)

  @article{ , abstract = {Individuals with homozygous laminA/C p.R527C mutations manifest a severe form of Mandibuloacral dysplasia-(MAD) and exhibit overlapping progeroid symptoms, for which the underlying molecular pathology remains unknown. Herein, it is shown that MAD patients achieved inflammaging with different pro-inflammatory cytokines compared to progeria-(HGPS) patient. Characterization of MAD iPSC-derived Mesenchymal stem cells (MAD-iMSC) uncovers deregulated mitochondrial Ca +2 as the primary cause of inflammaging, mediated through inflammasome formation rather than the cGAS-STING pathway. Moreover, MAD-iMSCs extracellular vesicles (EVs) can also upregulate mitochondrial Ca +2 in healthy cells. This deregulated Ca +2 homeostasis is indirectly mediated by mitochondrial calcium mediator, signal transducer, and activator of transcription-3 (STAT3), situated on the mitochondrial associated membrane (MAM). Inflammaging is mitigated by various FDA-approved MAM-STAT3 upstream inhibitors, such as (Tocilizumab) or by correcting R527C mutation with CRISPR/CAS9. These results provide new insights into MAD disease and propose targeting defective mitochondrial Ca +2 homeostasis as a promising therapy for reversing immunosenescence.}, archive = {J_ADVS}, author = {Arshad Ahmed Padhiar and Xiaohong Yang and Syed Aqib Ali Zaidi and Zhu Li and Jinqi Liao and Wei Shu and Arif Ali Chishti and Liangge He and Gulzar Alam and Abdullah Faqeer and Ilyas Ali and Shuai Zhang and Ting Wang and Tao Liu and Meiling Zhou and Gang Wang and Yan Zhou and Guangqian Zhou}, doi = {10.1002/advs.202407398}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407398}, shortjournal = {Adv. Sci.}, title = {MAM-STAT3-driven mitochondrial ca+2 upregulation contributes to immunosenescence in type a mandibuloacral dysplasia patients}, volume = {12}, year = {2025}, }
• (2025). Sustainable fabrication and transfer of high-precision nanoparticle arrays using recyclable chemical pattern templates. ADVS, 12(5), 2407393. (www)

  @article{ , abstract = {Nanoparticle (NP) arrays, particularly those with plasmonic properties, have diverse applications in electronics, photonics, catalysis, and biosensing, but their precise and scalable fabrication remains challenging. In this work, a facile chemical-based strategy is presented for the fabrication of precise NP patterns using a combination of soft thermal nanoimprinting and template-directed assembly. The approach enables the creation of well-defined NP arrays with single-particle resolution and yields over 99%, covering a diverse range of NP sizes from 30 to 150 nm. These patterns can be transferred onto various substrates including semiconductors, insulators, 2D materials, and flexible polymers, maintaining high uniformity and repeatability for over 60 cycles with minimal degradation. Moreover, the method enables the fabrication of extensive NP arrays up to 1 cm 2 with a positional accuracy of ±11 nm for 30 nm NPs. As a result, the obtained silver NP arrays exhibit ultranarrow surface lattice resonances with a linewidth of 4 nm and a quality factor ( Q ) of 216. The method offers new avenues for the creation of plasmonic NP arrays for flexible and wearable devices.}, archive = {J_ADVS}, author = {Huaining Zha and Wenjie Zhang and Peng Chen and Jing Tao and Li Qiu and Fan Yang and Shunsheng Ye and Yutao Sang and Zhihong Nie}, doi = {10.1002/advs.202407393}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407393}, shortjournal = {Adv. Sci.}, title = {Sustainable fabrication and transfer of high-precision nanoparticle arrays using recyclable chemical pattern templates}, volume = {12}, year = {2025}, }
• (2025). DNMT3a downregulation ttriggered upregulation of GABAA receptor in the mPFC promotes paclitaxel-induced pain and anxiety in male mice. ADVS, 12(5), 2407387. (www)

  @article{ , abstract = {Chemotherapeutic agents, such as paclitaxel (PTX), induce neuroplastic changes and alter gene expression in the prefrontal cortex (PFC), which may be associated with chemotherapy-induced pain and negative emotions. Notably, DNA methylation undergoes adaptive changes in neurological disorders, emerging as a promising target for neuromodulation. In this study, systemic administration of PTX leads to a decrease in the expression of the DNA methyltransferase DNMT3a, while concurrently upregulating the expression of Gabrb1 mRNA and its encoded GABA A Rβ1 protein in the medial PFC (mPFC) of male mice. Overexpression of DNMT3a in the mPFC alleviates PTX-induced pain hypersensitivity, and anxiety-like behavior in these mice. Additionally, it reverses the PTX-induced increase in inhibitory synaptic transmission in the pyramidal neurons of the mPFC. Mechanistically, the upregulation of GABA A Rβ1 in the mPFC is linked to the reduced expression of DNMT3a and DNA hypomethylation at the promoter region of the Gabrb1 gene. Furthermore, a long-term diet rich in methyl donors alleviates PTX-induced pain hypersensitivity and anxiety-like behavior in mice. These findings suggest that the DNMT3a-mediated upregulation of GABA A Rβ1 in the mPFC contributes to PTX-induced neuropathic pain and anxiety, highlighting DNA methylation-dependent epigenetic regulation as a potential therapeutic target for addressing chemotherapy-induced cortical dysfunction.}, archive = {J_ADVS}, author = {Lixia Tian and Xu-Hui Li and Yu-Long Zhao and Hui-Yuan Yi and Xue-Ru Liu and Rongrong Yao and Xue-Mei Hou and Xuan Zhu and Fu-Quan Huo and Tao Chen and Lingli Liang}, doi = {10.1002/advs.202407387}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407387}, shortjournal = {Adv. Sci.}, title = {DNMT3a downregulation ttriggered upregulation of GABAA receptor in the mPFC promotes paclitaxel-induced pain and anxiety in male mice}, volume = {12}, year = {2025}, }
• (2025). Single-nucleus RNA sequencing reveals that gabra6+ neurons in prefrontal cortex promote the progression of PTSD after shockwave-induced TBI. ADVS, 12(5), 2407000. (www)

  @article{ , abstract = {Shockwave-induced traumatic brain injury (TBI) results in the onset of post-traumatic stress disorder (PTSD), triggered either by the TBI itself or other stressors. However, the interplay and underlying mechanisms of how these factors synergistically induce PTSD remain inadequately elucidated. Here, mice in the TBI (induced by biological shock tube blast injury) and PTSD (induced by single prolonged stress method) groups both displayed symptoms of PTSD behaviors, with the TBI+PTSD (composite model) group exhibiting more severe manifestations. The result of snRNA-seq demonstrated a noticeable increase in the population of Gabra6 + neurons in the prefrontal cortex region of mice in the TBI+PTSD group. Knocking down cortical Gabra6 mitigated PTSD-related behavioral outcomes. Mechanistically, the Smad3/4 complex activation led to the upregulation of Gabra6 expression in cortical neurons. Interaction of Gabra6 with Homer1 activated downstream cAMP signaling pathways. Homer1 KO-Nestin mice show reduced susceptibility to PTSD. Subsequently, the efficacy of monoclonal antibody intervention at the 218 site of Gabra6 in ameliorating PTSD development is verified. This study suggests that TBI and stressors act as independent components in PTSD development, with Gabra6 + neurons pivotal in synergistically facilitating PTSD formation. Strategies geared toward minimizing exposure to singular or combined stressors may effectively diminish the risk of developing PTSD.}, archive = {J_ADVS}, author = {Xiaowei Fei and Zehan Zhang and Ya-nan Dou and Weihao Lv and Hongqing Chen and Li Wang and Xin He and Wangshu Chao and Peng Luo and Zhou Fei}, doi = {10.1002/advs.202407000}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2407000}, shortjournal = {Adv. Sci.}, title = {Single-nucleus RNA sequencing reveals that gabra6+ neurons in prefrontal cortex promote the progression of PTSD after shockwave-induced TBI}, volume = {12}, year = {2025}, }
• (2025). Cholesterol targeted catalytic hydrogel fueled by tumor debris can enhance microwave ablation therapy and anti-tumor immune response. ADVS, 12(5), 2406975. (www)

  @article{ , abstract = {The immunosuppressive residual tumor microenvironment (IRTM) is a key factor in the high recurrence and metastasis rates of hepatocellular carcinoma (HCC) after microwave ablation (MWA). Cholesterol-rich tumor fragments significantly contribute to IRTM deterioration. This study developed a cholesterol-targeted catalytic hydrogel, DA-COD-OD-HCS, to enhance the synergy between MWA and immune checkpoint inhibitors (ICIs) for HCC treatment. Cholesterol oxidase (COD), modified with dimethyl maleic anhydride (DA) for release in acidic IRTM, is used to degrade cholesterol. Oxydextran (OD) and hemin-chitosan (HCS) formed a dual network gel, ensuring long-term fixation of COD and hemin in the IRTM post-MWA. In both in vitro and in vivo HCC models, DA-COD-OD-HCS effectively released COD, degraded cholesterol, and induced tumor cell ferroptosis, enhancing the antitumor immune response. Combined with anti-PD-L1 immunotherapy, this strategy inhibited primary tumor growth and distant metastases, without side effects on adjacent tissues. This work highlights that cholesterol-targeting catalytic hydrogels fueled by tumor debris can significantly improve the efficacy of MWA and ICIs, offering a novel therapeutic approach for HCC.}, archive = {J_ADVS}, author = {Lin Shen and Zhijuan Yang and Yi Zhong and Yanran Bi and Junchao Yu and Qinwei Lu and Yanping Su and Xiaoxiao Chen and Zhongwei Zhao and Gaofeng Shu and Minjiang Chen and Liang Cheng and Liangzhu Feng and Chenying Lu and Zhuang Liu and Jiansong Ji}, doi = {10.1002/advs.202406975}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2406975}, shortjournal = {Adv. Sci.}, title = {Cholesterol targeted catalytic hydrogel fueled by tumor debris can enhance microwave ablation therapy and anti-tumor immune response}, volume = {12}, year = {2025}, }
• (2025). A study on the inflammatory response of the brain in neurosyphilis. ADVS, 12(5), 2406971. (www)

  @article{ , abstract = {Neurosyphilis (NS) is a clinical condition caused by infection of the central nervous system (CNS) by Treponema pallidum ( Tp ) that can lead to asymptomatic meningitis and more serious neurological diseases, such as dementia and blindness. However, current studies on the pathogenesis of NS are limited. Here, through the integration analysis of proteomics and single-cell transcriptomics, Toll-like/NF-κB signaling is identified as the key pathway involved in CNS damage caused by Tp . Moreover, monocyte-derived macrophages are key cells involved in the inflammatory response to Tp in the CNS of NS patients. In addition, it is found that inflammatory cells in peripheral blood may cause neurological damage through disruption of the blood‒brain barrier (BBB) in individuals with NS. Notably, activation of the Toll-like/NF-κB signaling pathway, as well as dysregulation of neural function, is likewise validated in an in vitro NS brain organoid model. In conclusion, the results revealed the mechanisms of inflammation-mediated brain injury in Tp -induced NS and provided new ideas for the clinical treatment of Tp infection.}, archive = {J_ADVS}, author = {Qiyu Zhang and Jie Ma and Jia Zhou and Hanlin Zhang and Mansheng Li and Huizi Gong and Yujie Wang and Heyi Zheng and Jun Li and Ling Leng}, doi = {10.1002/advs.202406971}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2406971}, shortjournal = {Adv. Sci.}, title = {A study on the inflammatory response of the brain in neurosyphilis}, volume = {12}, year = {2025}, }
• (2025). JUNB O-GlcNAcylation-mediated promoter accessibility of metabolic genes modulates distinct epithelial lineage in pulmonary fibrosis. ADVS, 12(5), 2406751. (www)

  @article{ , abstract = {Idiopathic pulmonary fibrosis (IPF) is a lethal disease with substantial unmet medical needs. While aberrant epithelial remodeling is a key factor in IPF progression, the molecular mechanisms behind this process remain elusive. Harnessing a 3D patient-derived organoid model and multi-omics approach, the first inventory of the connection between metabolic alteration, chromatin accessibility, and transcriptional regulation in IPF aberrant epithelial remodeling is provided. This remodeling is characterized by an increase in chromatin accessibility, particularly at JUNB motif-enriched promoter regions proximal to transcription start sites of metabolic and pro-fibrotic genes. Mechanistically, JUNB undergoes O-linked β-N-acetylglucosamine modification (O-GlcNAcylation), a critical step in modulating pro-fibrotic responses to chronic injury. This modification is pivotal in fostering the emergence of aberrant epithelial basal cells in the alveolar niche, a proposed driver of IPF pathology. Specific deletion of O-GlcNAcylation sites on JUNB attenuates the metaplastic differentiation of basal cells, thereby aiding in the restoration of the alveolar lineage. Together, the findings reveal a novel link between metabolic dysregulation and cell fate regulation at the chromatin level in fibrosis, mediated by the O-GlcNAc-JUNB axis, suggesting avenues for the development of new therapeutic strategies in IPF.}, archive = {J_ADVS}, author = {Marie-Therese Bammert and Meshal Ansari and Leoni Haag and Zuhdi Ahmad and Victoria Schröder and Joseph Birch and Diana Santacruz and Werner Rust and Coralie Viollet and Benjamin Strobel and Alec Dick and Florian Gantner and Holger Schlüter and Fidel Ramirez and Muriel Lizé and Matthew J. Thomas and Huy Q. Le}, doi = {10.1002/advs.202406751}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2406751}, shortjournal = {Adv. Sci.}, title = {JUNB O-GlcNAcylation-mediated promoter accessibility of metabolic genes modulates distinct epithelial lineage in pulmonary fibrosis}, volume = {12}, year = {2025}, }
• (2025). Utilizing AI for the identification and validation of novel therapeutic targets and repurposed drugs for endometriosis. ADVS, 12(5), 2406565. (www)

  @article{ , abstract = {Endometriosis affects over 190 million women globally, and effective therapies are urgently needed to address the burden of endometriosis on women's health. Using an artificial intelligence (AI)-driven target discovery platform, two unreported therapeutic targets, guanylate-binding protein 2 (GBP2) and hematopoietic cell kinase (HCK) are identified, along with a drug repurposing target, integrin beta 2 (ITGB2) for the treatment of endometriosis. GBP2, HCK, and ITGB2 are upregulated in human endometriotic specimens. siRNA-mediated knockdown of GBP2 and HCK significantly reduced cell viability and proliferation while stimulating apoptosis in endometrial stromal cells. In subcutaneous and intraperitoneal endometriosis mouse models, siRNAs targeting GBP2 and HCK notably reduced lesion volume and weight, with decreased proliferation and increased apoptosis within lesions. Both subcutaneous and intraperitoneal administration of Lifitegrast, an approved ITGB2 antagonist, effectively suppresses lesion growth. Collectively, these data present Lifitegrast as a previously unappreciated intervention for endometriosis treatment and identify GBP2 and HCK as novel druggable targets in endometriosis treatment. This study underscores AI's potential to accelerate the discovery of novel drug targets and facilitate the repurposing of treatment modalities for endometriosis.}, archive = {J_ADVS}, author = {Bonnie Hei Man Liu and Yuezhen Lin and Xi Long and Sze Wan Hung and Anna Gaponova and Feng Ren and Alex Zhavoronkov and Frank W. Pun and Chi Chiu Wang}, doi = {10.1002/advs.202406565}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2406565}, shortjournal = {Adv. Sci.}, title = {Utilizing AI for the identification and validation of novel therapeutic targets and repurposed drugs for endometriosis}, volume = {12}, year = {2025}, }
• (2025). The Lyn/RUVBL1 complex promotes colorectal cancer liver metastasis by regulating arachidonic acid metabolism through chromatin remodeling. ADVS, 12(5), 2406562. (www)

  @article{ , abstract = {Liver metastasis is a common cause of death in colorectal cancer (CRC) patients, but epigenetic remodeling and metabolic reprogramming for CRC liver metastasis remain unclear. The study revealed that the Lyn/RUVBL1 complex is highly expressed in CRC and is closely correlated with liver metastasis. On the one hand, ATAC-seq and HiCut suggested that Lyn/RUVBL1 regulates the expression of TRIB3 through the POL II-mediated chromatin conformation of TRIB3 and thus the expression of β-catenin. This promotes the proliferation and migration of CRC through β-catenin-mediated upregulation of MMP9 and VEGF. On the other hand, metabolomics revealed that Lyn/RUVBL1 regulates the expression of PGE2 through the enzyme COX2, thereby promoting arachidonic acid (AA) metabolism. CUT-Tag showed that Lyn/RUVBL1 silencing reduces the H3K27ac level in the COX2 promoter. Then, it is found that COX2 is regulated by the transcription factor FOXA1. Lyn/RUVBL1 modulates AA metabolism by regulating the chromatin accessibility of FOXA1. AA metabolism promotes the metastasis of CRC by affecting β-catenin nuclear translocation and upregulating MMP9 and VEGF. These findings suggest that the Lyn/RUVBL1 complex mediates epigenetic remodeling to regulate the metabolic reprogramming of AA, highlighting its role in promoting the metastasis of CRC.}, archive = {J_ADVS}, author = {Zhenyu Zhang and Yina Gao and Yuanyuan Qian and Bowen Wei and Kexin Jiang and Zhiwei Sun and Feifan Zhang and Mingming Yang and Salem Baldi and Xiaoqi Yu and Yunfei Zuo and Shuangyi Ren}, doi = {10.1002/advs.202406562}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2406562}, shortjournal = {Adv. Sci.}, title = {The Lyn/RUVBL1 complex promotes colorectal cancer liver metastasis by regulating arachidonic acid metabolism through chromatin remodeling}, volume = {12}, year = {2025}, }
• (2025). Clostridium scindens protects against vancomycin-induced cholestasis and liver fibrosis by activating intestinal FXR-FGF15/19 signaling. ADVS, 12(5), 2406445. (www)

  @article{ , abstract = {Primary sclerosing cholangitis (PSC) is characterized by abnormal bile acid metabolites and altered gut microbiota, with no effective treatments available. Vancomycin, a glycopeptide antibiotic, has emerged as a promising candidate. However, the mechanism by which vancomycin impacts the progression of PSC remains unknown. Mice treated with vancomycin exhibit increased hepatic collagen deposition and injury, due to the inhibition of intestinal FXR-FGF15/19 axis and the elevation of bile acid levels. These effects are associated with the reduction in Clostridia XIVa , especially Clostridium scindens ( C. scindens ). Gavage of C. scindens alleviates vancomycin-induced bile acid accumulation and liver fibrosis via activating intestinal FXR-FGF15/19 signaling. Similar effects are observed in mice treated with engineered Escherichia coli Nissle 1917 that are capable of expressing bile acid 7α-dehydratas (BaiE) from C. scindens (EcN-BaiE). Activating intestinal FXR-FGF15/19 signaling by fexaramine (Fex) or recombinant protein FGF19 reverse vancomycin-induced liver injury and fibrosis. These results demonstrate that long-term oral vancomycin exacerbates cholestatic liver injury, while C. scindens mitigates this effect by activating the intestinal FXR-FGF15/19 signaling pathway. This underscores the importance of monitoring bile acid levels in PSC patients receiving vancomycin treatment and suggests that C. scindens may serve as a potential therapeutic approach for PSC patients.}, archive = {J_ADVS}, author = {Jintao Xiao and Yanliang Hou and Xingyang Luo and Yuhao Zhu and Wenhu Li and Bingbing Li and LinXiang Zhou and Xia Chen and Ying Guo and Xiaomei Zhang and Haiyue He and Xiaowei Liu}, doi = {10.1002/advs.202406445}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2406445}, shortjournal = {Adv. Sci.}, title = {Clostridium scindens protects against vancomycin-induced cholestasis and liver fibrosis by activating intestinal FXR-FGF15/19 signaling}, volume = {12}, year = {2025}, }
• (2025). Platelet–Monocyte aggregate instigates inflammation and vasculopathy in kawasaki disease. ADVS, 12(5), 2406282. (www)

  @article{ , abstract = {Kawasaki disease (KD) is a severe acute febrile illness and systemic vasculitis that causes coronary artery aneurysms in young children. Platelet hyperreactivity and an aberrant immune response are key indicators of KD; however, the mechanism by which hyperactive platelets contribute to inflammation and vasculopathy in KD remains unclear. A cytokine-mediated positive feedback loop between KD platelets and monocytes is identified. KD platelet–monocyte aggregates (MPAs) are mediated by an initial interaction of P-selectin (cluster of differentiation 62P, CD62p) and its glycoprotein ligand 1 (PSGL-1). This is followed by a coordinated interaction of platelet glycoprotein (GP)Ibα with monocyte CD11b. Monocyte-activated platelets initiate transforming growth factor (TGF)β1 release, which results in nuclear localization of nuclear factor kappaB in monocytes, therefore, driving the phenotypic conversion of classical monocytes (CD14 + CD16 − ) into proinflammatory monocytes (CD14 + CD16 + ). The platelet-activated monocytes release interleukin-1 and tissue necrotic factor-α, which promote further platelet activation. KD-induced inflammation and vasculopathy are prevented by inhibiting the components of this positive feedback loop. Notably, mice deficient in platelet TGFβ1 show less MPA and CD14 + CD16 + monocytes, along with reduced inflammation and vasculopathy. These findings reveal that platelet–monocyte interactive proteins (CD62p/PSGL-1 and (GP)Ibα/CD11b) and cytokine mediators (platelet TGFβ1) are potential biomarkers and therapeutic targets for KD vasculopathy.}, archive = {J_ADVS}, author = {Yuan Zhang and Cuiping Jia and Manli Guo and Qian Chen and Ying Wen and Ting Wang and Yinyin Xie and Xuejiao Fan and Jingwen Gao and Timur O. Yarovinsky and Renjing Liu and Zhiyong Jiang and Mengmeng Wang and Jin Zhou and Di Che and Lanyan Fu and Richard Edelson and Xiaoqiong Gu and John Hwa and Wai Ho Tang}, doi = {10.1002/advs.202406282}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2406282}, shortjournal = {Adv. Sci.}, title = {Platelet–Monocyte aggregate instigates inflammation and vasculopathy in kawasaki disease}, volume = {12}, year = {2025}, }
• (2025). Tumor microenvironment-responsive nanoparticles enhance IDO1 blockade immunotherapy by remodeling metabolic immunosuppression. ADVS, 12(5), 2405845. (www)

  @article{ , abstract = {The clinical efficacy of immune checkpoint blockade (ICB) therapy is significantly compromised in the metabolically disordered tumor microenvironment (TME), posing a formidable challenge that cannot be ignored in current antitumor strategies. In this study, TME-responsive nanoparticles (HMP1G NPs) loaded with 1-methyltryptophan (1-MT; an indoleamine 2,3-dioxygenase 1 [IDO1] inhibitor,) and S-nitrosoglutathione (GSNO; a nitric oxide donor) is developed to enhance the therapeutic efficacy of 1-MT-mediated ICB. The HMP1G NPs responded to H + and glutathione in the TME, releasing Mn 2+ , GSNO, and 1-MT. The released Mn 2+ catalyzed the production of abundant reactive oxygen species and nitric oxide from hydrogen peroxide and GSNO, and the generated nitric oxide, synergistically with 1-MT, inhibited the accumulation of kynurenine mediated by IDO1 in the tumor. Mechanistically, HMP1G NPs downregulated tumor cell-derived IDO1 via the aryl hydrocarbon receptor/signal transducer and activator of transcription 3/interleukin signaling axis to improve kynurenine/tryptophan metabolism and immunosuppression. In a murine breast cancer model, treatment with HMP1G NPs elicited effective antitumor immunity and enhanced survival outcomes. This study highlights a novel nano-platform that simultaneously improves metabolism and enhances ICB efficacy to achieve a new and efficient antitumor strategy.}, archive = {J_ADVS}, author = {Mengna Wang and Yuhong Liu and Yanshi Li and Tao Lu and Min Wang and Zhaobo Cheng and Lin Chen and Tongling Wen and Min Pan and Guohua Hu}, doi = {10.1002/advs.202405845}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2405845}, shortjournal = {Adv. Sci.}, title = {Tumor microenvironment-responsive nanoparticles enhance IDO1 blockade immunotherapy by remodeling metabolic immunosuppression}, volume = {12}, year = {2025}, }
• (2025). Single-nucleus and spatial transcriptome profiling delineates the multicellular ecosystem in hepatocellular carcinoma after hepatic arterial infusion chemotherapy. ADVS, 12(5), 2405749. (www)

  @article{ , abstract = {Hepatic arterial infusion chemotherapy (HAIC) has emerged as a promising treatment strategy for hepatocellular carcinoma (HCC), but a detailed understanding of the multicellular ecosystem after HAIC treatment is lacking. Here, we collected tumor samples from treatment-naïve primary and post-HAIC HCC, and integrated single-nucleus RNA sequencing with spatial transcriptomics to characterize the tumor ecosystem in the post-HAIC HCC. Increased fractions and enhanced cellular communication of CD4 + T, CD20 + B, and dendritic cell subtypes were identified in post-HAIC tumors. Moreover, it is substantiated that HAIC promoted tertiary lymphoid structures (TLS) formation, and addressed the roles of TLSs as spatial niches of cellular communication. Specifically, intermediate exhausted CD8 + T cells expressing Granzyme-K and PD-1 (PD-1 + CD8 + Tex-int) expanded following HAIC and exhibited a functionally antitumor phenotype. PD-1 + CD8 + Tex-int accumulated in the TLS vicinity and disseminated throughout the tumor microenvironment, demonstrating potential as an effective biomarker for HAIC-based treatment in HCC. This study provides valuable resources and biological insights in the cellular underpinnings of HAIC treatment.}, archive = {J_ADVS}, author = {YeXing Huang and ZeFeng Du and ZhiCheng Lai and DongSheng Wen and LiChang Huang and MinKe He and ZiChao Wu and HuiFang Li and HanYue OuYang and WenChao Wu and Anna Kan and Ming Shi}, doi = {10.1002/advs.202405749}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2405749}, shortjournal = {Adv. Sci.}, title = {Single-nucleus and spatial transcriptome profiling delineates the multicellular ecosystem in hepatocellular carcinoma after hepatic arterial infusion chemotherapy}, volume = {12}, year = {2025}, }
• (2025). Extreme electron-photon interaction in disordered perovskites. ADVS, 12(5), 2405709. (www)

  @article{ , abstract = {The interaction of light with solids can be dramatically enhanced owing to electron-photon momentum matching. This mechanism manifests when light scattering from nanometer-sized clusters including a specific case of self-assembled nanostructures that form a long-range translational order but local disorder (crystal-liquid duality). In this paper, a new strategy based on both cases for the light-matter-interaction enhancement in a direct bandgap semiconductor – lead halide perovskite CsPbBr 3 – by using electric pulse-driven structural disorder, is addressed. The disordered state allows the generation of confined photons, and the formation of an electronic continuum of static/dynamic defect states across the forbidden gap (Urbach bridge). Both mechanisms underlie photon-momentum-enabled electronic Raman scattering (ERS) and single-photon anti-Stokes photoluminescence (PL) under sub-band pump. PL/ERS blinking is discussed to be associated with thermal fluctuations of cross-linked [PbBr 6 ] 4- octahedra. Time-delayed synchronization of PL/ERS blinking causes enhanced spontaneous emission at room temperature. These findings indicate the role of photon momentum in enhanced light-matter interactions in disordered and nanostructured solids.}, archive = {J_ADVS}, author = {Sergey S. Kharintsev and Elina I. Battalova and Ivan A. Matchenya and Albert G. Nasibulin and Alexander A. Marunchenko and Anatoly P. Pushkarev}, doi = {10.1002/advs.202405709}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2405709}, shortjournal = {Adv. Sci.}, title = {Extreme electron-photon interaction in disordered perovskites}, volume = {12}, year = {2025}, }
• (2025). AI-powered multimodal modeling of personalized hemodynamics in aortic stenosis. ADVS, 12(5), 2404755. (www)

  @article{ , abstract = {Aortic stenosis (AS) is the most common valvular heart disease in developed countries. High-fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. However, their use is currently limited by complex workflows necessitating lengthy expert-driven manual operations. Here, we propose an AI-powered computational framework for accelerated and democratized patient-specific modeling of AS hemodynamics from computed tomography (CT). First, we demonstrate that the automated meshing algorithms can generate task-ready geometries for both computational and benchtop simulations with higher accuracy and 100 times faster than existing approaches. Then, we show that the approach can be integrated with fluid-structure interaction and soft robotics models to accurately recapitulate a broad spectrum of clinical hemodynamic measurements of diverse AS patients. The efficiency and reliability of these algorithms make them an ideal complementary tool for personalized high-fidelity modeling of AS biomechanics, hemodynamics, and treatment planning.}, archive = {J_ADVS}, author = {Caglar Ozturk and Daniel H. Pak and Luca Rosalia and Debkalpa Goswami and Mary E. Robakowski and Raymond McKay and Christopher T. Nguyen and James S. Duncan and Ellen T. Roche}, doi = {10.1002/advs.202404755}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2404755}, shortjournal = {Adv. Sci.}, title = {AI-powered multimodal modeling of personalized hemodynamics in aortic stenosis}, volume = {12}, year = {2025}, }
• (2025). S-PLM: Structure-aware protein language model via contrastive learning between sequence and structure. ADVS, 12(5), 2404212. (www)

  @article{ , abstract = {Proteins play an essential role in various biological and engineering processes. Large protein language models (PLMs) present excellent potential to reshape protein research by accelerating the determination of protein functions and the design of proteins with the desired functions. The prediction and design capacity of PLMs relies on the representation gained from the protein sequences. However, the lack of crucial 3D structure information in most PLMs restricts the prediction capacity of PLMs in various applications, especially those heavily dependent on 3D structures. To address this issue, S-PLM is introduced as a 3D structure-aware PLM that utilizes multi-view contrastive learning to align the sequence and 3D structure of a protein in a coordinated latent space. S-PLM applies Swin-Transformer on AlphaFold-predicted protein structures to embed the structural information and fuses it into sequence-based embedding from ESM2. Additionally, a library of lightweight tuning tools is provided to adapt S-PLM for diverse downstream protein prediction tasks. The results demonstrate S-PLM's superior performance over sequence-only PLMs on all protein clustering and classification tasks, achieving competitiveness comparable to state-of-the-art methods requiring both sequence and structure inputs. S-PLM and its lightweight tuning tools are available at https://github.com/duolinwang/S-PLM/ .}, archive = {J_ADVS}, author = {Duolin Wang and Mahdi Pourmirzaei and Usman L. Abbas and Shuai Zeng and Negin Manshour and Farzaneh Esmaili and Biplab Poudel and Yuexu Jiang and Qing Shao and Jin Chen and Dong Xu}, doi = {10.1002/advs.202404212}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2404212}, shortjournal = {Adv. Sci.}, title = {S-PLM: Structure-aware protein language model via contrastive learning between sequence and structure}, volume = {12}, year = {2025}, }
• (2025). Profiling pro-inflammatory proteases as biomolecular signatures of material-induced subcutaneous host response in immuno-competent mice. ADVS, 12(5), 2309709. (www)

  @article{ , abstract = {Proteases are important modulators of inflammation, but they remain understudied in material-induced immune response, which is critical to clinical success of biomedical implants. Herein, molecular expression and proteolytic activity of three distinct proteases, namely neutrophil elastase, matrix metalloproteinases, cysteine cathepsins (cathepsin-K and cathepsin-B) are comprehensively profiled, in the subcutaneous host response of immuno-competent mice against different biomaterial implants. Quantitative non-invasive monitoring with activatable fluorescent probes reveals that different microparticulate materials induce distinct levels of protease activity with degradable poly(lactic-co-glycolic) acid inducing the strongest signal compared to nondegradable materials such as polystyrene and silica oxide. Furthermore, protein expression of selected proteases, attributable to both their inactive and active forms, notably deviates from their activities associated only with their active forms. Protease activity exhibits positive correlations with protein expression of pro-inflammatory cytokines tumor necrosis factor α and interleukin 6 but negative correlation with pro-fibrotic cytokine transforming growth factor β1. This study also demonstrates the predictive utility of protease activity as a non-invasive, pro-inflammatory parameter for evaluation of the anti-inflammatory effects of model bioactive compounds on material-induced host response. Overall, the findings provide new insights into protease presence in material-induced immune responses, facilitating future biomaterial assessment to evoke appropriate host responses for implant applications.}, archive = {J_ADVS}, author = {Nam M.P. Tran and Anh T.H. Truong and Dang T. Nguyen and Tram T. Dang}, doi = {10.1002/advs.202309709}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2309709}, shortjournal = {Adv. Sci.}, title = {Profiling pro-inflammatory proteases as biomolecular signatures of material-induced subcutaneous host response in immuno-competent mice}, volume = {12}, year = {2025}, }
• (2025). Implantable ultrasound-powered MXene/PVA hydrogel-based generator for treatment of glioblastoma. ADVS, 12(5), 2309610. (www)

  @article{ , abstract = {Glioblastoma (GBM) is a lethal disease with a poor prognosis due to its strong infiltration, which makes it difficult to remove completely. In this study, an implantable, modulus-tunable, and ultrasound-powered MXene/PVA hydrogel-based tumor treatment device (UP-MPH-TTD), which generates specific electromagnetic alternating fields that disrupt the mitosis of cancer cells without adversely affecting normal neurons is developed. The MXene/PVA hydrogel is used to form a tumor treatment field due to its high biocompatibility, excellent flexibility, and high conductivity, which improves ultrasonic electrical conversion efficiency and significantly reduces the size of the equipment. The implantable UP-MPH-TTD is wirelessly ultrasound-powered, small-sized, lightweight, and simply structured, significantly boosting therapeutic efficiency and reducing restrictions on patient movement. In vitro and in vivo experiments confirmed the device's therapeutic effect, demonstrating a ≈92% inhibition rate in the growth of clinical tumor cells and a 73% reduction in tumor area in tumor-bearing mice. The promising results indicate the broad application potential of the device in the treatment and prognostic improvement of GBM.}, archive = {J_ADVS}, author = {Xiaoping Hu and Ziyi Qiu and Yilin Yang and Ting Xu and Kai Sheng and Weicheng Lu and Jingdun Xie and Bingzhe Xu}, doi = {10.1002/advs.202309610}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2309610}, shortjournal = {Adv. Sci.}, title = {Implantable ultrasound-powered MXene/PVA hydrogel-based generator for treatment of glioblastoma}, volume = {12}, year = {2025}, }
• (2025). Schwann cell-specific ablation of beclin 1 impairs myelination and leads to motor and sensory neuropathy in mice. ADVS, 12(5), 2308965. (www)

  @article{ , abstract = {The core component of the class III phosphatidylinositol 3-kinase complex, Beclin 1, takes part in different protein networks, thus switching its role from inducing autophagy to regulating autophagosomal maturation and endosomal trafficking. While assessed in neurons, astrocytes, and microglia, its role is far less investigated in myelinating glia, including Schwann cells (SCs), responsible for peripheral nerve myelination. Remarkably, the dysregulation in endosomal trafficking is emerging as a pathophysiological mechanism underlying peripheral neuropathies, such as demyelinating Charcot-Marie-Tooth (CMT) diseases. By knocking out Beclin 1 in SCs here a novel mouse model ( Becn1 cKO) is generated, developing a severe and progressive neuropathy, accompanied by involuntary tremors, body weight loss, and premature death. Ultrastructural analysis revealed abated myelination and SCs displaying enlarged cytoplasm with progressive accumulation of intracellular vesicles. Transcriptomic and histological analysis from sciatic nerves of 10-day and 2-month-old mice revealed pro-mitotic gene deregulation and increased SCs proliferation at both stages with axonal loss and increased immune infiltration in adults, well reflecting the progressive motor and sensory functional impairment that characterizes Becn1 cKO mice, compared to controls. The study establishes a further step in understanding key mechanisms in SC development and points to Beclin 1 and its regulated pathways as targets for demyelinating CMT forms.}, archive = {J_ADVS}, author = {Lisa Gambarotto and Loris Russo and Silvia Bresolin and Luca Persano and Rachele D'Amore and Giulia Ronchi and Federica Zen and Luisa Muratori and Alice Cani and Samuele Negro and Aram Megighian and Sonia Calabrò and Paola Braghetta and Dario Bizzotto and Matilde Cescon}, doi = {10.1002/advs.202308965}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2308965}, shortjournal = {Adv. Sci.}, title = {Schwann cell-specific ablation of beclin 1 impairs myelination and leads to motor and sensory neuropathy in mice}, volume = {12}, year = {2025}, }
• (2025). PRMT1 promotes the self-renewal of leukemia stem cells by regulating protein synthesis. ADVS, 12(5), 2308586. (www)

  @article{ , abstract = {The application of tyrosine kinase inhibitors (TKIs) has revolutionized the management of chronic myeloid leukemia (CML). However, disease relapse and progression particularly due to persistent leukemia stem cells (LSCs) remain a big challenge in the clinic. Therefore, validation of the therapeutic vulnerability in LSCs is urgently needed. This study verifies the critical role of protein arginine methyltransferase 1 (PRMT1) in the maintenance of CML LSCs. It is found that PRMT1 promotes the survival and serially plating abilities of human primary CML LSCs. Genetic deletion of Prmt1 significantly delays the leukemogenesis and impairs the self-renewal of LSCs in BCR-ABL – driven CML mice. PRMT1 regulates LSCs and leukemia development depending on its methyltransferase activity. Pharmacological inhibition of PRMT1 activity by MS023 remarkably eliminates LSCs and prolongs the survival of CML mice. Mechanistical studies reveal that PRMT1 promotes transcriptional activation of ribosomal protein L29 (RPL29) via catalyzing asymmetric dimethylation of histone H4R3 (H4R3me2a) at its gene promoter region. PRMT1 augments the global protein synthesis via RPL29 in CML LSCs. Taken together, the findings provide new evidence that histone arginine methylation modification regulates protein synthesis in LSCs and highlight PRMT1 as a valuable druggable target for patients with CML.}, archive = {J_ADVS}, author = {Min Zhou and Yi Huang and Ping Xu and Shuyi Li and Chen Duan and Xiaoying Lin and Shilai Bao and Waiyi Zou and Jingxuan Pan and Chang Liu and Yanli Jin}, doi = {10.1002/advs.202308586}, journal = {Advanced Science}, month = {2}, number = {5}, pages = {2308586}, shortjournal = {Adv. Sci.}, title = {PRMT1 promotes the self-renewal of leukemia stem cells by regulating protein synthesis}, volume = {12}, year = {2025}, }
• (2025). Highly tunable moiré superlattice potentials in twisted hexagonal boron nitrides (Adv. sci. 4/2025). ADVS, 12(4), 2570023. (www)

  @article{ , archive = {J_ADVS}, author = {Kwanghee Han and Minhyun Cho and Taehyung Kim and Seung Tae Kim and Suk Hyun Kim and Sang Hwa Park and Sang Mo Yang and Kenji Watanabe and Takashi Taniguchi and Vinod Menon and Young Duck Kim}, doi = {10.1002/advs.202570023}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2570023}, shortjournal = {Adv. Sci.}, title = {Highly tunable moiré superlattice potentials in twisted hexagonal boron nitrides (Adv. sci. 4/2025)}, volume = {12}, year = {2025}, }
• (2025). Optical visualization of stretchable serpentine interconnects using chiral liquid crystal elastomers (Adv. sci. 4/2025). ADVS, 12(4), 2570022. (www)

  @article{ , archive = {J_ADVS}, author = {Sang Hyun Han and Jun Hyuk Shin and Hak Jun Yang and Seungmin Nam and Ji Yoon Park and Su Seok Choi}, doi = {10.1002/advs.202570022}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2570022}, shortjournal = {Adv. Sci.}, title = {Optical visualization of stretchable serpentine interconnects using chiral liquid crystal elastomers (Adv. sci. 4/2025)}, volume = {12}, year = {2025}, }
• (2025). Pathological microenvironment-remodeling nanoparticles to alleviate liver fibrosis: Reversing hepatocytes-hepatic stellate cells malignant crosstalk (Adv. sci. 4/2025). ADVS, 12(4), 2570021. (www)

  @article{ , archive = {J_ADVS}, author = {Ling-Feng Zhang and Wen-Qi Deng and Xing-Huan Wang and Qing-Wen Huang and Su-Qing Liang and Ze-Quan Ding and Liang Qi and Yi Wang and Tian-Jiao Zhou and Lei Xing and Jai-Woo Lee and Yu-Kyoung Oh and Hu-Lin Jiang}, doi = {10.1002/advs.202570021}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2570021}, shortjournal = {Adv. Sci.}, title = {Pathological microenvironment-remodeling nanoparticles to alleviate liver fibrosis: Reversing hepatocytes-hepatic stellate cells malignant crosstalk (Adv. sci. 4/2025)}, volume = {12}, year = {2025}, }
• (2025). High Quality–Factor All–Dielectric metacavity for Label–Free biosensing (Adv. sci. 4/2025). ADVS, 12(4), 2570020. (www)

  @article{ , archive = {J_ADVS}, author = {Yuqiao Zheng and Jiacheng Sun and Yaqing Ma and Hongyong Zhang and Zhen Cui and Giannis G. Paschos and Xixi Song and Ying Tao and Pavlos Savvidis and Wei Kong and Liaoyong Wen and Sumin Bian and Mohamad Sawan}, doi = {10.1002/advs.202570020}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2570020}, shortjournal = {Adv. Sci.}, title = {High Quality–Factor All–Dielectric metacavity for Label–Free biosensing (Adv. sci. 4/2025)}, volume = {12}, year = {2025}, }
• (2025). RETRACTION: Direct formation of hard-magnetic tetrataenite in bulk alloy castings. ADVS, 12(4), 2416229. (www)

  @article{ , abstract = {RETRACTION : Yurii P. Ivanov, Baran Sarac, Sergey V. Ketov, Jürgen Eckert, A. Lindsay Greer “Direct Formation of Hard-Magnetic Tetrataenite in Bulk Alloy Castings,” Advanced Science 10, no. 1 (2023): 1–8, https://doi.org/10.1002/advs.202204315 . The above article, published online on 25 October 2023 in Wiley Online Library (wileyonlinelibrary.com) has been retracted by agreement between the journal Editor-in-Chief, Kirsten Severing; and Wiley-VCH GmbH. After publication, the authors informed the journal about a potential misinterpretation of the experimental data that affected the overall conclusions of this manuscript. Subsequently, a team of authors at the University of Cambridge, including the original corresponding author, performed additional experiments which eventually confirmed that the findings presented were not correct. A Comment by this author group, that shows new experiments and discusses the reinterpretation of the original results will be published [1]. S.V.K. disagrees with the retraction while Y.P.I., B.S., J.E., and A.L.G. agree. References [1] Owain S. Houghton, James C. Loudon, Alison C. Twitchett-Harrison, Nikolaos T. Panagiotopoulos, Giulio I. Lampronti, Miguel B. Costa, Richard J. Harrison, A. Lindsay Greer “Reinterpretation of Report of Tetrataenite in Bulk Alloy Castings,” Advanced Science 11, (2024): (accepted), https://doi.org/10.1002/advs.202408796 .}, archive = {J_ADVS}, doi = {10.1002/advs.202416229}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2416229}, shortjournal = {Adv. Sci.}, title = {RETRACTION: Direct formation of hard-magnetic tetrataenite in bulk alloy castings}, volume = {12}, year = {2025}, }
• (2025). Controllable strategy of Metal–Organic framework structural stability: Regulation of ligand electronegativity by esterification. ADVS, 12(4), 2413853. (www)

  @article{ , abstract = {Structural stability of metal–organic framework (MOF) is crucial for their application, and thus it is of great significance to construct MOFs with controllable structural stability. Herein, a strategy based on adjusting the electronic environment of ligands to regulate the structure stability of MOF is proposed. Briefly, a novel Zr-MOF (Zr-TA) with hydroxyl groups is synthesized. The hydroxyl groups are esterified to obtain ester groups with stronger electronegativity, which can weaken the strength of coordination between metal ion and ligand, thereby regulating the structure stability of the Zr-MOF. Notably, this strategy can achieve controllable adjustment of the structure by adding modifiers at the appropriate time. In this work, this strategy is used to greatly improving the binding ability of MOF and collagen fibers, the hydrothermal stability of crosslinked collagen fibers is enhanced by 82.6%. Surprisingly, this strategy can also be applied to other application fields that require dynamic changes in structural stability of MOF. It will open up a new pathway for controlling the structural stability and application performance of MOF.}, archive = {J_ADVS}, author = {Guanjie Huang and Jianzhong Ma and Jie Chen and Wenbo Zhang and Qianqian Fan and Buxing Han}, doi = {10.1002/advs.202413853}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2413853}, shortjournal = {Adv. Sci.}, title = {Controllable strategy of Metal–Organic framework structural stability: Regulation of ligand electronegativity by esterification}, volume = {12}, year = {2025}, }
• (2025). Nanodrug-engineered exosomes achieve a jointly dual-pathway inhibition on cuproptosis. ADVS, 12(4), 2413408. (www)

  @article{ , abstract = {Cuproptosis, caused by an intracellular overload of copper (Cu) ions and overexpression of ferredoxin 1 (FDX1), is identified for its regulatory role in the skin wound healing process. This study verifies the presence of cuproptosis in skin wound beds and reactive oxygen species-induced cells model. To address the two pathways leading to cell cuproptosis, a nanodrug-engineered exosomes is proposed. A Cu-chelator (Clioquinol, CQ) polydopamine (PDA)-modified stem cell exosome loaded with siRNA-FDX1, named EXO siFDX1-PDA@CQ , is designed to efficiently inhibit the two cuproptosis pathways. The functionalized exosomes are loaded into an injectable hydrogel and applied to treat diabetic wounds in mice and acute skin wounds in pigs. The local and controlled release of EXO siFDX1-PDA@CQ ensures the retention of the therapeutic agent at wound beds, effectively promoting wound healing. The strategy of engineered exosomes with functional nanoparticles (NPs) proposed in this study offers an efficient and scalable new approach for regulating cuproptosis.}, archive = {J_ADVS}, author = {Hanxiao Sun and Yang Zou and Zhengtai Chen and Yan He and Kai Ye and Huan Liu and Lihong Qiu and Yufan Zhang and Yuexue Mai and Xinghong Chen and Zhengwei Mao and Wei Wang and Chenggang Yi}, doi = {10.1002/advs.202413408}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2413408}, shortjournal = {Adv. Sci.}, title = {Nanodrug-engineered exosomes achieve a jointly dual-pathway inhibition on cuproptosis}, volume = {12}, year = {2025}, }
• (2025). Microwave ablation combined with Flt3L provokes tumor-specific memory CD8+ t cells-mediated antitumor immunity in response to PD-1 blockade. ADVS, 12(4), 2413181. (www)

  @article{ , abstract = {For medically inoperable non-small cell lung cancer, microwave ablation (MWA) represents a super minimally invasive alternative treatment. However, tumor recurrence remains a concern. Here, it is demonstrated that the combination of MWA with Flt3L significantly inhibits tumor recurrence by CD8 + central memory T (T CM )-like cell-dependent antitumor immune responses within the tumor-draining lymph nodes (TdLN). TdLN-T CM -like cells encompassed both tumor-specific memory T (T TSM ) and progenitor-exhausted T (T PEX ) cells. The expansion of these cells markedly altered the differentiation of exhausted T cells within the tumor microenvironment (TME). T PEX predominantly differentiated into transitory effector-like exhausted T cells (T EX -int). The expansion of T TSM cells elicited by the combined therapy was reliant on conventional dendritic cells (cDCs) and was likely specifically dependent on the migratory cDC1s (Mig cDC1s) within the TdLN. The upregulation of ICOSL on migratory cDC1s was pivotal in initiating T TSM -like cell-mediated antitumor responses. Slc38a2 may be a critical gene responsible for the upregulation of ICOSL in Mig cDC1s following combined treatment. Finally, the combined treatment significantly enhanced the antitumor efficacy of immunotherapy based on PD-1 blockade. The research thereby afforded a novel strategic approach to forestall tumor recurrence after MWA therapy, while also providing the foundational proof-of-concept for impending clinical investigations.}, archive = {J_ADVS}, author = {Meixiang Wang and Jing Sang and Fengkuo Xu and Shulong Wang and Peng Liu and Ji Ma and Zhengtao Chen and Qi Xie and Zhigang Wei and Xin Ye}, doi = {10.1002/advs.202413181}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2413181}, shortjournal = {Adv. Sci.}, title = {Microwave ablation combined with Flt3L provokes tumor-specific memory CD8+ t cells-mediated antitumor immunity in response to PD-1 blockade}, volume = {12}, year = {2025}, }
• (2025). High catalytic selectivity of Electron/Proton dual-conductive sulfonated polyaniline micropore encased IrO2 electrocatalyst by screening effect for oxygen evolution of seawater electrolysis. ADVS, 12(4), 2412862. (www)

  @article{ , abstract = {Acidic seawater electrolysis offers significant advantages in high efficiency and sustainable hydrogen production. However, in situ electrolysis of acidic seawater remains a challenge. Herein, a stable and efficient catalyst (SPTTPAB/IrO 2 ) is developed by coating iridium oxide (IrO 2 ) with a microporous conjugated organic framework functionalized with sulfonate groups (-SO 3 H) to tackle these challenges. The SPTTPAB/IrO 2 presents a -SO 3 H concentration of 5.62 × 10 −4 mol g −1 and micropore below 2 nm numbering 1.026 × 10 16 g −1 . Molecular dynamics simulations demonstrate that the conjugated organic framework blocked 98.62% of Cl − in seawater from reaching the catalyst. This structure combines electron conductivity from the organic framework and proton conductivity from -SO 3 H, weakens the Cl − adsorption, and suppresses metal-chlorine coupling, thus enhancing the catalytic activity and selectivity. As a result, the overpotential for the oxygen evolution reaction (OER) is only 283 mV@10 mA cm −2 , with a Tafel slope of 16.33 mV dec −1 , which reduces 13.8% and 37.8% compared to commercial IrO 2 , respectively. Impressively, SPTTPAB/IrO 2 exhibits outstanding seawater electrolysis performance, with a 35.3% improvement over IrO 2 to 69 mA cm −2 @1.9 V, while the degradation rate (0.018 mA h −1 ) is only 24.6% of IrO 2 . This study offers an innovative solution for designing high-performance seawater electrolysis electrocatalysts.}, archive = {J_ADVS}, author = {Yuhan Shen and Shengqiu Zhao and Fanglin Wu and Hao Zhang and Liyan Zhu and Mingjuan Wu and Tian Tian and Haolin Tang}, doi = {10.1002/advs.202412862}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2412862}, shortjournal = {Adv. Sci.}, title = {High catalytic selectivity of Electron/Proton dual-conductive sulfonated polyaniline micropore encased IrO2 electrocatalyst by screening effect for oxygen evolution of seawater electrolysis}, volume = {12}, year = {2025}, }
• (2025). Mechanically twisting-induced top-down chirality transfer for tunable full-color circularly polarized luminescent fibers. ADVS, 12(4), 2412778. (www)

  @article{ , abstract = {Circularly polarized luminescence (CPL) materials with rich optical information are highly attractive for optical display, information storage, and encryption. Although previous investigations have shown that external force fields can induce CPL activity in nonchiral systems, the unique role of macroscopic external forces in inducing CPL has not been demonstrated at the level of molecule or molecular aggregate. Here, a canonical example of CPL generation by mechanical twisting in an achiral system consisting of a polymer matrix with embedded fluorescent molecules is presented. By carefully adjusting the twisting parameters in time and space, in conjunction with circular dichroism (CD), CPL, and 2D wide-angle X-ray scattering (2D WAXS) studies, a twisting-induced top-down chiral transfer mechanism derived from the molecular-level asymmetric rearrangement of fluorescent units is elucidated within polymers under external torsional forces. This top-down chiral transfer provides a simple, scalable, and versatile mechanical twisting strategy for the fabrication of CPL materials, allowing for fabricating full-color and handedness-tunable CPL fibers, where the macroscopic twist direction determines the CPL handedness. Moreover, the weavability of CPL fibers greatly extend their applications in anti-counterfeit encryption, as demonstrated by using embroidery techniques to design multilevel encryption patterns.}, archive = {J_ADVS}, author = {Xiaoxiao Yu and Linfeng Chen and Qin Liu and Xiaoqing Liu and Zhenduo Qiu and Xinhai Zhang and Meifang Zhu and Yanhua Cheng}, doi = {10.1002/advs.202412778}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2412778}, shortjournal = {Adv. Sci.}, title = {Mechanically twisting-induced top-down chirality transfer for tunable full-color circularly polarized luminescent fibers}, volume = {12}, year = {2025}, }
• (2025). Metal-mediated chlorine transfer for molten salt-driven thermodynamic change on silicon production. ADVS, 12(4), 2412239. (www)

  @article{ , abstract = {The development of silicon (Si) material poses a great challenge with profound technological advancements for semiconductors, photo/photoelectric systems, solar cells, and secondary batteries. Typically, Si production involves the thermochemical reduction of silicon oxides, where chloride salt additives help properly revamp the reaction mechanism. Herein, we unravel the chemical principles of molten AlCl 3 salt in metallothermic reduction. Above its melting temperature ( T m ≈ 192 °C), three AlCl 3 molecules coordinate with each metal (M) atom (e.g., conventional Al and Mg, or even thermodynamically unfeasible Zn) to form metal-AlCl 3 complexes, M(AlCl 3 ) 3 . In the molten AlCl 3 salt media, all complexes directly lead to the universal formation of AlOCl byproduct and as-reduced Si spheres through internal Cl * transfer during the reduction reaction. Intriguingly, highly oxophilic metal (i.e., Mg) establishes additional energetic shortcuts in reaction pathways, where AlCl 3 directly detaches an oxygen atom, accompanied by strong metal-oxygen interactions and Cl * transfer within the same complex. Moreover, the thermodynamic stability of the metal-AlCl 3 complex residue (MAl 2 Cl 8 ) and the microstructure of post-treated Si do change according to the metal choice, imparting disparate physicochemical properties for Si. This work offers insights into the scalable production of tailored Si materials for industrial applications, along with cost-effective operations at 250 °C.}, archive = {J_ADVS}, author = {Minjun Je and Jin Chul Kim and Jiyeon Kim and Sungho Kim and Sunmin Ryu and Jaegeon Ryu and Sang Kyu Kwak and Soojin Park}, doi = {10.1002/advs.202412239}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2412239}, shortjournal = {Adv. Sci.}, title = {Metal-mediated chlorine transfer for molten salt-driven thermodynamic change on silicon production}, volume = {12}, year = {2025}, }
• (2025). Injectable hierarchical bioactive hydrogels with fibroblast growth factor 21/Edaravone/Caffeic acid asynchronous delivery for treating parkinson's disease. ADVS, 12(4), 2412020. (www)

  @article{ , abstract = {Parkinson's disease (PD) is one of the most common long-term neurodegenerative disorders, with multiple comorbid psychiatric and behavioral abnormalities. The combination of clinical drugs targeting different symptoms with smart hydrogels to achieve asynchronous releases is highly translational and challenging. Here, a hierarchical bioactive hydrogel (OACDP) is designed with asynchronous release based on PD pathology. The hydrogel with caffeic acid-grafted polymer main chain is crosslinked using a micellar nanocrosslinker, with sufficient modulus (≈167 Pa), antioxidant activity (> 50%), injectability (30-gauge syringe needle), and shape-adaptability. Each of the three drugs (caffeic acid, fibroblast growth factor 21, and Edaravone) is separately engaged in different micro- or nanostructures of the hydrogel and released with asynchronous kinetics of first-order release, zero-order release, or matching Korsmeyer–Peppas model. The triple-loaded hydrogel is injected into the brains of PD rats, showing behavioral improvement. Histological analysis revealed that the triple-loaded OACDP hydrogels are effective in achieving immediate neuroprotection, i.e., reduction the loss of tyrosine hydroxylase in substantia nigra compacta and striatum (retained ≈10-fold versus control), decreasing oxidative stress, reducing astrocyte and microglia activation, and stimulating the AMPK/PGC-1α axis to regulate the mitochondrial function, providing a multi-dimensional PD therapy. The asynchronous release of OACDP hydrogel provides a new conception for PD treatment and other neurodegenerative diseases.}, archive = {J_ADVS}, author = {Junpeng Xu and Peng Dai and Chen Zhang and Na Dong and Caiyan Li and Chonghui Tang and Zhihao Jin and Shih-Ho Lin and Luyang Ye and Tianmiao Sun and Yukai Jin and Fenzan Wu and Lihua Luo and Ping Wu and Shengcun Li and Xiaokun Li and Shan-hui Hsu and Dawei Jiang and Zhouguang Wang}, doi = {10.1002/advs.202412020}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2412020}, shortjournal = {Adv. Sci.}, title = {Injectable hierarchical bioactive hydrogels with fibroblast growth factor 21/Edaravone/Caffeic acid asynchronous delivery for treating parkinson's disease}, volume = {12}, year = {2025}, }
• (2025). The ZnO-SiO2 composite phase with dual regulation function enables uniform zn2+ flux and fast zinc deposition kinetics toward zinc metal batteries. ADVS, 12(4), 2411995. (www)

  @article{ , abstract = {As an important candidate for rechargeable energy storage devices, the large-scale development of aqueous zinc ion batteries has been hindered by hydrogen evolution and uncontrollable dendrites of metal anodes. A novel ZnO-SiO 2 composite interface phase (Zn@ZSCP) with a double protective effect based on in situ synthesis by hydrothermal method is used to improve these difficulties. The hydrophilic SiO 2 layer is beneficial to the dissolution of hydrated zinc ions and reduces the nucleation barrier during zinc deposition, while the stable ZnO layer helps to adjust the electric field distribution on the surface of the metal anode to further induce uniform zinc nucleation. The cycle life of the Zn@ZSCP||Zn@ZSCP symmetric battery based on this innovative interface phase modification is up to 2500 h. Even at a high current density of 8 mA cm −2 , the symmetric battery still has a stable cycle life of more than 2000 h. The zinc-iodine full battery based on Zn@ZSCP anode and low-cost biomass-derived porous carbon exhibits an excellent specific capacity and outstanding cycle stability. This simple and reasonable battery structure design not only improves the practicability of aqueous zinc ion batteries to a certain extent but also helps to develop more efficient and environmentally friendly zinc metal batteries.}, archive = {J_ADVS}, author = {Dongfang Guo and Fengyu Li and Bin Zhang}, doi = {10.1002/advs.202411995}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411995}, shortjournal = {Adv. Sci.}, title = {The ZnO-SiO2 composite phase with dual regulation function enables uniform zn2+ flux and fast zinc deposition kinetics toward zinc metal batteries}, volume = {12}, year = {2025}, }
• (2025). Revolutionizing underwater sensor performance: Tackling rayleigh scattering challenges by pseudo random noise. ADVS, 12(4), 2411967. (www)

  @article{ , abstract = {Traditionally, Rayleigh scattering is thought to only impact fiber sensing system performance when the leading fiber is over 10 km long. However, this report illustrates theoretically and experimentally that Rayleigh scattering cannot be ignored in fiber optic interferometric sensor (FOIS) even with several hundred-meter common leading fiber because of the interaction of Rayleigh backward scattering (RBS) and returning interference signal. Herein, a conceptual framework is developed to elucidate the interaction between RBS and FOIS interference, revealing that, beyond laser monochromacity, the self-correction characteristic of laser pulses also influences coherent superposition. Building upon this novel insight, a phase modulation method based on pseudorandom noise (PRN) code is first proposed to address coherent RBS stacking on returning FOIS interferences while preserving high laser monochromacity. By modulating the interrogation pulses, a 21.3 dB suppression of background phase noise is achieved in FOIS with 3.3 km leading fiber. This study offers a holistic understanding of Rayleigh scattering in the leading fiber, encompassing experimental observations, theoretical modeling, physics analysis, and its resolution, thereby contributing to advancements in underwater sensing to broaden the understanding of the underwater environment.}, archive = {J_ADVS}, author = {Qihao Hu and Fan Shang and Lina Ma and Wujie Wang and Yi Yu and Yujie Bian and Xiaoqian Zhu and Junqiang Song}, doi = {10.1002/advs.202411967}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411967}, shortjournal = {Adv. Sci.}, title = {Revolutionizing underwater sensor performance: Tackling rayleigh scattering challenges by pseudo random noise}, volume = {12}, year = {2025}, }
• (2025). Water-triggered reconfigurable glycerogels for sustainable all-gel supercapacitors. ADVS, 12(4), 2411847. (www)

  @article{ , abstract = {The polymeric structures of synthetic gels are typically static, which makes them damage-prone and nonrecyclable. Inspired by the dynamic reconfigurability of biological tissues, which eliminate old/damaged cells and regenerate new ones via biological triggers/signals, a reconfigurable biopolymer gel is presented based on a glycerol-mediated supramolecular gelation strategy. In response to an eco-friendly triggering agent water, this gel undergoes on-demand molecular-level reconfiguration. The versatility of the approach enables the development of reconfigurable gels with modulated functionality. As a proof-of-concept, a reconfigurable glycerogel electrode and electrolyte are developed and used to prototype an all-gel supercapacitor that exhibits exceptional self-healing, degradation, and rebuilding abilities. Furthermore, it can tolerate extreme mechanical deformations (e.g., stretching, bending, and twisting) and temperatures (−20 to 80 °C). The device exhibits excellent energy storage performance, with a maximum areal capacitance of 450 mF cm −2 (at 0.035 mA cm −2 ) and remarkable capacitance retention of 89% following 20 000 charge/discharge cycles (at 0.35 mA cm −2 ). Moreover, following self-healing and rebuilding, the capacitance remains at 91% and 110% (at 0.35 mA cm −2 ) of the original value, respectively. This generalized strategy for preparing multifunctional reconfigurable gels will facilitate the development of high-performance flexible and wearable devices with improved durability and recyclability.}, archive = {J_ADVS}, author = {Md. Tariful Islam Mredha and Adith Varma Rama Varma and Tanish Gupta and Insu Jeon}, doi = {10.1002/advs.202411847}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411847}, shortjournal = {Adv. Sci.}, title = {Water-triggered reconfigurable glycerogels for sustainable all-gel supercapacitors}, volume = {12}, year = {2025}, }
• (2025). CeO2−δ as electron donor in Co0.07Ce0.93O2−δ solid solution boosts alkaline water splitting. ADVS, 12(4), 2411845. (www)

  @article{ , abstract = {Optimizing the electronic structure with increasing intrinsic stability is a usual method to enhance the catalysts’ performance. Herein, a series of cerium dioxide (CeO 2−δ ) based solid solution materials is synthesized via substituting Ce atoms with transition metal (Co, Cu, Ni, etc.), in which Co 0.07 Ce 0.93 O 2−δ shows optimized band structure because of electron transition in the reaction, namely Co 3+ (3d 6 4s 0 ) + Ce 3+ (4f 1 5d 0 6s 0 ) → Co 2+ (3d 7 4s 0 ) + Ce 4+ (4f 0 5d 0 6s 0 ), with more stable electronic configuration. The in situ Raman spectra show a stable F2g peak at ≈452 cm −1 of Co 0.07 Ce 0.93 O 2−δ , while the F2g peak in CeO 2−δ almost disappeared during HER progress, demonstrating the charge distribution of *H adsorbed on Co 0.07 Ce 0.93 O 2−δ is more stable than *H adsorbed on CeO 2−δ . Density functional theory calculations reveal that Co 0.07 Ce 0.93 O 2−δ solid solution increases protonation capacity and favors for formation of *H in alkaline media. General guidelines are formulated for optimizing adsorption capacity and the volcano plot demonstrates the excellent catalytic performance of Co 0.07 Ce 0.93 O 2−δ solid solution. The alkaline anion exchange membrane water electrolysis based on Co 0.07 Ce 0.93 O 2−δ /NiFe LDH realizes a current density of 1000 mA cm −2 at ≈1.86 V in alkaline seawater at 80 °C and exhibits long-term stability for 450 h.}, archive = {J_ADVS}, author = {Gege Su and Yichao Hou and Jie Yin and Jiayi Yang and Zhenglong Li and Xin Du and Xin Zhang and Pinxian Xi and Chun-Hua Yan}, doi = {10.1002/advs.202411845}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411845}, shortjournal = {Adv. Sci.}, title = {CeO2−δ as electron donor in Co0.07Ce0.93O2−δ solid solution boosts alkaline water splitting}, volume = {12}, year = {2025}, }
• (2025). Co–In bimetallic hydroxide nanosheet arrays with coexisting hydroxyl and metal vacancies anchored on rod-like MOF template for enhanced photocatalytic CO2 reduction. ADVS, 12(4), 2411673. (www)

  @article{ , abstract = {Layered double hydroxides (LDHs) can serves as catalysts for CO 2 photocatalytic reduction (CO 2 PR). However, the conventionally synthesized LDHs undergo undesired aggregation, which results in an insufficient number of active sites and limits the desirable electron transfer required for CO 2 PR. The metal-organic framework (MOF) template-grown LDHs demonstrate excellent promise for exploiting the strengths of both MOFs and LDHs. Herein, the in situ growth of MIL-68(In)-NH 2 MOF-templated Co–In bimetallic catalyst (CoIn-LDH/MOF) having an ultrathin nanosheet morphology on the preserved rod-like MOF template is demonstrated. Compared to the conventionally grown bimetallic LDH (CoIn-LDH), CoIn-LDH/MOF not only exposes more active sites but also possesses hydroxyl vacancies ( V OH ) and Co vacancies ( V Co ). Thus, CoIn-LDH/MOF performs a higher CO generation rate of 2320 µmol g −1 h −1 during CO 2 PR, demonstrating improved activity and selectivity than those in CoIn-LDH. Experiments coupled with calculations reveal that the CoIn-LDH/MOF-driven CO 2 PR follows the * COOH pathway. The lower energy barriers for the formation of * COOH and CO(g) can be attributed to the coexistence of V OH and V Co in CoIn-LDH/MOF, effectively promoting charge transfer and enhancing CO 2 PR performance. This study provides a new strategy to obtain high-performant LDH-based catalysts with improved morphology.}, archive = {J_ADVS}, author = {Jingjuan Feng and Weiwei Li and Tianxia Chen and Zhaopeng Zeng and Meng Tian and Wenxin Ji and Yan Guo and Shixiong Min and Xiangyu Liu}, doi = {10.1002/advs.202411673}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411673}, shortjournal = {Adv. Sci.}, title = {Co–In bimetallic hydroxide nanosheet arrays with coexisting hydroxyl and metal vacancies anchored on rod-like MOF template for enhanced photocatalytic CO2 reduction}, volume = {12}, year = {2025}, }
• (2025). Strong bonding of lattice n activates metal ni to achieve efficient water splitting. ADVS, 12(4), 2411526. (www)

  @article{ , abstract = {Developing efficient and robust free-standing electrocatalysts for overall water splitting is a promising but challenging task. Herein, the N-incorporated Ni nanosheets non-fully encapsulated by N-doped carbon (NC) layer are fabricated (N─Ni©NC). The introduction of N not only regulates the size of nanosheets in N─Ni©NC but also promotes the electrochemical activity of metal Ni. Experimental and theoretical results reveal that strong bonding of the lattice N activates the inert metal Ni by promoting charge transfer between Ni and N. In addition, the upward shift of the d-band center induced by lattice N enhances the adsorption of intermediates, thereby making Ni as a new OER active site together with C. This strategy of generating Ni and C dual active sites by introducing lattice N greatly accelerates oxygen evolution reaction (OER) kinetics, resulting in excellent electrocatalytic performance of N─Ni©NC. At the current density of 10 mA cm −2 , the overpotentials of hydrogen evolution reaction (HER) and OER are 27 and 206 mV, respectively, and the cell voltage for overall water splitting only needs 1.47 V. This work offers a unique heteroatom activation approach for designing free-standing electrodes with high activity.}, archive = {J_ADVS}, author = {Niandan Zhao and Wei Luo and Sijun Li and Hua Wang and Yini Mao and Yimin Jiang and Wenbin Wang and Ming Li and Wei Su and Rongxing He}, doi = {10.1002/advs.202411526}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411526}, shortjournal = {Adv. Sci.}, title = {Strong bonding of lattice n activates metal ni to achieve efficient water splitting}, volume = {12}, year = {2025}, }
• (2025). An on-chip second-order elastic topological insulator for demultiplexing out-of-plane and in-plane corner modes. ADVS, 12(4), 2411398. (www)

  @article{ , abstract = {Second-order elastic topological insulators (SETIs) with tightly localized corner states present a promising avenue for manipulating elastic waves in lower dimensions. However, existing SETIs typically support corner states of only a single mode, either out-of-plane or in-plane. In this work, an on-chip SETI that simultaneously hosts both high-frequency out-of-plane and in-plane corner states at ≈0.2 MHz is introduced. The presence of these corner states is experimentally validated, and their selective excitation by tuning the excitation frequency is demonstrated. This capability to demultiplex out-of-plane and in-plane corner states positions the SETI as a potential platform for developing multifunctional elastic devices and enhancing the communication capacities of elastic waves. Furthermore, due to its structural simplicity, the SETI can be readily scaled and integrated into on-chip elastic circuits, making it suitable for applications in micro-electromechanical systems.}, archive = {J_ADVS}, author = {Yafeng Chen and Lei Fan and Jie Zhu and Zhongqing Su}, doi = {10.1002/advs.202411398}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411398}, shortjournal = {Adv. Sci.}, title = {An on-chip second-order elastic topological insulator for demultiplexing out-of-plane and in-plane corner modes}, volume = {12}, year = {2025}, }
• (2025). A smart nanomedicine unleashes a dual assault of glucose starvation and cuproptosis to supercharge αPD-l1 therapy. ADVS, 12(4), 2411378. (www)

  @article{ , abstract = {Combination therapy has become a promising strategy for promoting the outcomes of anti-programmed death ligand-1 (αPD-L1) therapy in lung cancer. Among all, emerging strategies targeting cancer metabolism have shown great potency in treating cancers with immunotherapy. Here, alteration in glucose and copper metabolisms is found to synergistically regulate PD-L1 expression in lung cancer cells. Thus, an intelligent biomimetic nano-delivery system is synthesized by camouflaging lung cancer cell membranes onto glucose oxidase-loaded Cu-LDHs (CMGCL) for cancer metabolism targeted interference. Such novel nanomedicine is able to induce lung cancer cell cuproptosis and PD-L1 upregulation significantly via self-amplified cascade reactions. Meanwhile, with a decent cancer cell membrane coating, CMGCL exhibited great biosafety, tumor-targeted efficiency and anti-tumor effects in LLC lung tumor-bearing mice models. Additionally, a combination of CMGCL can sensitize the therapeutic effects of αPD-L1, substantially promoting tumor inhibition in both subcutaneous and lung metastasis LLC-bearing mice models. Overall, these findings highlight the potential connections between glucose metabolism and cell cuproptosis, offering a promising approach for treating lung cancer by integrating starvation, cuproptosis, and immunotherapy.}, archive = {J_ADVS}, author = {Yiming Xu and Yuan Wu and Xinjie Zheng and Dongxue Wang and Hangqi Ni and Weiyu Chen and Kai Wang}, doi = {10.1002/advs.202411378}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411378}, shortjournal = {Adv. Sci.}, title = {A smart nanomedicine unleashes a dual assault of glucose starvation and cuproptosis to supercharge αPD-l1 therapy}, volume = {12}, year = {2025}, }
• (2025). Popcorn effect–inspired self-propagating formation of high-conductivity cement composite for multifunctional applications. ADVS, 12(4), 2411290. (www)

  @article{ , abstract = {The surge in modern civil technologies demands a transformation in cement composites to surpass traditional roles and integrate smart functionalities. In this regard, enhancing the electrical conductivity of cement composites is a critical challenge. This study introduces a novel strategy for the self-propagating formation of expandable graphite-based high-conductivity cement composites through a simple thermal treatment with 3 wt.% expandable graphite and 1 wt.%carbon fiber as conductive fillers. Inspired by the popcorn effect, this method leverages the rapid expansion of graphite at high temperatures, promoting contact between conductive fillers and forming new conductive networks. The obtained composites demonstrate a remarkable reduction of 60% in electrical resistance after heat treatment compared to the electrical resistance of standard cement composites, and the enhancing mechanisms is explored. The conductive properties endow the material with excellent electrothermal (>100 °C at 10 V), electrothermochromic (response time of 2 s), and electromagnetic interference shielding (42 dB at 12.4 GHz) performance. This innovative approach provides vast opportunities for developing smart infrastructure with enhanced electrical properties, regarded as a promising candidate for promoting next-generation buildings and infrastructures.}, archive = {J_ADVS}, author = {Haiping Wu and Jiaqi Huang and Zhengyao Qu and Xueling Zheng and Sirui Tan and Wei Du and Guanming Cai and Zhong Zhao and Jing Wu and Daiqi Li}, doi = {10.1002/advs.202411290}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411290}, shortjournal = {Adv. Sci.}, title = {Popcorn effect–inspired self-propagating formation of high-conductivity cement composite for multifunctional applications}, volume = {12}, year = {2025}, }
• (2025). Microfluidic nanoparticle separation for precision medicine. ADVS, 12(4), 2411278. (www)

  @article{ , abstract = {A deeper understanding of disease heterogeneity highlights the urgent need for precision medicine. Microfluidics, with its unique advantages, such as high adjustability, diverse material selection, low cost, high processing efficiency, and minimal sample requirements, presents an ideal platform for precision medicine applications. As nanoparticles, both of biological origin and for therapeutic purposes, become increasingly important in precision medicine, microfluidic nanoparticle separation proves particularly advantageous for handling valuable samples in personalized medicine. This technology not only enhances detection, diagnosis, monitoring, and treatment accuracy, but also reduces invasiveness in medical procedures. This review summarizes the fundamentals of microfluidic nanoparticle separation techniques for precision medicine, starting with an examination of nanoparticle properties essential for separation and the core principles that guide various microfluidic methods. It then explores passive, active, and hybrid separation techniques, detailing their principles, structures, and applications. Furthermore, the review highlights their contributions to advancements in liquid biopsy and nanomedicine. Finally, it addresses existing challenges and envisions future development spurred by emerging technologies such as advanced materials science, 3D printing, and artificial intelligence. These interdisciplinary collaborations are anticipated to propel the platformization of microfluidic separation techniques, significantly expanding their potential in precision medicine.}, archive = {J_ADVS}, author = {Zhenwei Lan and Rui Chen and Da Zou and Chun-Xia Zhao}, doi = {10.1002/advs.202411278}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411278}, shortjournal = {Adv. Sci.}, title = {Microfluidic nanoparticle separation for precision medicine}, volume = {12}, year = {2025}, }
• (2025). Single-cell simultaneous metabolome and transcriptome profiling revealing metabolite-gene correlation network. ADVS, 12(4), 2411276. (www)

  @article{ , abstract = {Metabolic studies at the single cell level can directly define the cellular phenotype closest to physiological or disease states. However, the current single cell metabolome (SCM) study using mass spectroscopy has difficulty giving a complete view of the metabolic activity in the cell, and the prediction of the metabolism-phenotype relationship is limited by the potential inconsistency between transcriptomic and metabolic levels. Here, the single-cell simultaneous metabolome and transcriptome profiling method (scMeT-seq) is developed at one single cell, based on sub-picoliter sampling from the cell for the initial metabolome profiling followed by single cell transcriptome sequencing. This design not only provides sufficient cytoplasm for SCM but also nicely keeps the cellular viability for the accurate transcriptomic analysis in the same cell. Integrative analysis of scMeT-seq reveals both dynamical and cell state-specific associations between metabolome and transcriptome in the macrophages with defined metabolic perturbations. Moreover, metabolite signatures are mapped to the single-cell trajectory and gene correlation network of macrophage transition, which allows the unsupervised functional interpretation of metabolome. Thus, the established scMeT-seq should lead to a new perspective in metabolic research by transforming metabolomics from a metabolite snapshot to a functional approach.}, archive = {J_ADVS}, author = {Xiying Mao and Dandan Xia and Miao Xu and Yan Gao and Le Tong and Chen Lu and Weiqi Li and Runmin Xie and Qinghuai Liu and Dechen Jiang and Songtao Yuan}, doi = {10.1002/advs.202411276}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411276}, shortjournal = {Adv. Sci.}, title = {Single-cell simultaneous metabolome and transcriptome profiling revealing metabolite-gene correlation network}, volume = {12}, year = {2025}, }
• (2025). Electron-lattice synergistic coordination for boosting the electro-optic response of the crystal. ADVS, 12(4), 2411143. (www)

  @article{ , abstract = {The electro-optic (E-O) response is fundamental where the refractive index of materials can be modulated by the external electric field. Up to now, E-O modulation has become a critical technology in photonics, quantum optics, modern communication, etc. However, the design of E-O crystals with broadband availabilities and large E-O effect is still challenging since the E-O response is contributed by both electrons and phonons. Here, an electron-lattice synergistic coordination strategy is proposed for boosting the E-O response, and with the langasite as the subject, a novel crystal La 3 Zr 0.5 Ga 5 Si 0.5 O 14 (LZGS) is designed. By the rational introduction of the Zr 4+ ion in the octahedral site, it is found that the E-O response can be obviously improved attributed to the active 4 d orbitals of the Zr 4+ ion and the optical phonons of the flexible (ZrO 6 ) unit. This crystal also has advantages in transparency, laser damage threshold and E-O coefficient compared with the well-known E-O crystals. Moreover, broadband E-O modulation is also demonstrated in the lasers at wavelengths from 639 to 1991 nm. These findings not only demonstrate an excellent E-O crystal for the development of modern devices in classical and quantum fields but also provide a design strategy for boosting the E-O response.}, archive = {J_ADVS}, author = {Jinfeng Han and Yuzhou Wang and Fei Liang and Kui Wu and Dazhi Lu and Deliang Cui and Haohai Yu and Huaijin Zhang}, doi = {10.1002/advs.202411143}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411143}, shortjournal = {Adv. Sci.}, title = {Electron-lattice synergistic coordination for boosting the electro-optic response of the crystal}, volume = {12}, year = {2025}, }
• (2025). Body surface potential mapping: A perspective on high-density cutaneous electrophysiology. ADVS, 12(4), 2411087. (www)

  @article{ , abstract = {The electrophysiological signals recorded by cutaneous electrodes, known as body surface potentials (BSPs), are widely employed biomarkers in medical diagnosis. Despite their widespread application and success in detecting various conditions, the poor spatial resolution of traditional BSP measurements poses a limit to their diagnostic potential. Advancements in the field of bioelectronics have facilitated the creation of compact, high-quality, high-density recording arrays for cutaneous electrophysiology, allowing detailed spatial information acquisition as BSP maps (BSPMs). Currently, the design of electrode arrays for BSP mapping lacks a standardized framework, leading to customizations for each clinical study, limiting comparability, reproducibility, and transferability. This perspective proposes preliminary design guidelines, drawn from existing literature, rooted solely in the physical properties of electrophysiological signals and mathematical principles of signal processing. These guidelines aim to simplify and generalize the optimization process for electrode array design, fostering more effective and applicable clinical research. Moreover, the increased spatial information obtained from BSPMs introduces interpretation challenges. To mitigate this, two strategies are outlined: observational transformations that reconstruct signal sources for intuitive comprehension, and machine learning-driven diagnostics. BSP mapping offers significant advantages in cutaneous electrophysiology with respect to classic electrophysiological recordings and is expected to expand into broader clinical domains in the future.}, archive = {J_ADVS}, author = {Ruben Ruiz-Mateos Serrano and Dario Farina and George G. Malliaras}, doi = {10.1002/advs.202411087}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411087}, shortjournal = {Adv. Sci.}, title = {Body surface potential mapping: A perspective on high-density cutaneous electrophysiology}, volume = {12}, year = {2025}, }
• (2025). Divergent adsorption regulation in Metal–Organic frameworks for highly efficient CF4/C2F6 separation. ADVS, 12(4), 2411083. (www)

  @article{ , abstract = {The efficient removal of low-concentration components from homologous mixtures is often hampered by the co-directional effect of traditional thermodynamic regulation approaches, typically leading to a trade-off between adsorption capacity and selectivity. Focusing this challenge on the critical task of purifying perfluorocarbons in electronics industry, a divergent regulation strategy is reported that significantly improves the separation efficiency of low-concentration hexafluoroethane (C 2 F 6 ) from tetrafluoromethane (CF 4 ). This approach involves the selective shielding of open metal sites and the modulation of channel geometry within an electron-deficient ligand-based pore environment, thereby facilitating a C 2 F 6 dense-packing accommodation mode while weakening the CF 4 affinity due to the reduced host-guest interactions. Simultaneously enhanced C 2 F 6 adsorption and reduced CF 4 adsorption are achieved, resulting in record-high low-pressure C 2 F 6 uptake and C 2 F 6 /CF 4 selectivity. Comprehensive insights into the unique separation mechanism are illustrated through a combination of solid-state MAS nuclear magnetic resonance (SSNMR), molecular simulations, and meticulously designed comparative experiments. As a result, benchmark C 2 F 6 /CF 4 separation performance is achieved, as demonstrated by the unprecedented electronic-grade (over 99.999%) CF 4 productivity (401 L kg −1 ) obtained from an industrially relevant C 2 F 6 /CF 4 (3:97) mixture, as well as the excellent water/air/heat stability and recyclability.}, archive = {J_ADVS}, author = {Guihong Xu and Tian Ke and Rongrong Fan and Kaiyuan Tan and Wenjun Zhang and Baogen Su and Zhiguo Zhang and Zongbi Bao and Qilong Ren and Qiwei Yang}, doi = {10.1002/advs.202411083}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411083}, shortjournal = {Adv. Sci.}, title = {Divergent adsorption regulation in Metal–Organic frameworks for highly efficient CF4/C2F6 separation}, volume = {12}, year = {2025}, }
• (2025). Programmable multiplexed nucleic acid detection by harnessing specificity defect of CRISPR-cas12a. ADVS, 12(4), 2411021. (www)

  @article{ , abstract = {CRISPR-Cas12a works like a sophisticated algorithm in nucleic acid detection, yet its challenge lies in sometimes failing to distinguish targets with mismatches due to its specificity limitations. Here, the mismatch profiles, including the quantity, location, and type of mismatches in the CRISPR-Cas12a reaction, are investigated and its various tolerances to mismatches are discovered. By harnessing the specificity defect of the CRISPR-Cas12a enzyme, a dual-mode detection strategy is designed, which includes approximate matching and precise querying of target sequences and develop a programmable multiplexed nucleic acid assay. With the assay, 14 high-risk human papillomavirus (HPV) subtypes are simultaneously detected, collectively responsible for 99% of cervical cancer cases, with attomolar sensitivity. Specifically, the assay not only distinguishes HPV16 and HPV18, the two most common subtypes but also detects 12 other high-risk pooled HPV subtypes. To enable low-cost point-of-care testing, the assay is incorporated into a paper-based microfluidic chip. Furthermore, the clinical performance of the paper-based microfluidic chip is validated by testing 75 clinical swab samples, achieving performance comparable to that of PCR. This programmable multiplexed nucleic acid assay has the potential to be widely applied for sensitive, specific, and simultaneous detection of different pathogens.}, archive = {J_ADVS}, author = {Xin Guan and Rui Yang and Jiongyu Zhang and Jeong Moon and Chengyu Hou and Chong Guo and Lori Avery and Danielle Scarola and Daniel S. Roberts and Rocco LaSala and Changchun Liu}, doi = {10.1002/advs.202411021}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2411021}, shortjournal = {Adv. Sci.}, title = {Programmable multiplexed nucleic acid detection by harnessing specificity defect of CRISPR-cas12a}, volume = {12}, year = {2025}, }
• (2025). “Brick-mortar-binder” design toward highly elastic, hydrophobic, and flame-retardant thermal insulator. ADVS, 12(4), 2410938. (www)

  @article{ , abstract = {Advanced aerogels hold immense potential in thermal insulation. However, achieving high environmental adaptability aerogel insulators with elasticity, hydrophobicity, flame-retardancy, and low temperature tolerance remains a significant challenge. Inspired by a “brick-mortar-binder” biomimetic texture, a layered double hydroxide/carboxylated cellulose nanofibers/Si–O–Si (LCS) hybrid aerogel is developed by bottom-up freeze-drying. Owing to the distinct building blocks and organized structure, as-prepared LCS hybrid aerogel exhibits impressive mechanical elasticity, cycling stability at an extremely low temperature (-196 °C), hydrophobicity, and flame-retardancy (LOI = 44.6%, UL-94: V-0). Additionally, the incorporation of layered double hydroxide effectively improves the thermal insulation property (thermal conductivity = 0.0296 W·m −1 ·K −1 ). These distinctive features make the LCS hybrid aerogel highly promising for thermal management applications in extreme conditions, such as in pipelines for transporting liquid nitrogen and liquefied natural gas.}, archive = {J_ADVS}, author = {Shanying Sui and Huafeng Quan and Jingxing Wang and Yufang Lu and Yufan Yang and Yuhan Sheng and Zhifang Sun and Yi Zhang}, doi = {10.1002/advs.202410938}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410938}, shortjournal = {Adv. Sci.}, title = {“Brick-mortar-binder” design toward highly elastic, hydrophobic, and flame-retardant thermal insulator}, volume = {12}, year = {2025}, }
• (2025). Synergetic phase modulation and N-doping of MoS2 for highly sensitive flexible NO2 sensors. ADVS, 12(4), 2410825. (www)

  @article{ , abstract = {Molybdenum disulfide (MoS 2 ) is a promising electronic material owing to its excellent electrochemical features, high carrier mobility at room temperature, and widely tunable electronic properties. Here, through precursor engineering and post-treatments to tailor their phase and doping, electronic characteristics of MoS 2 are significantly modified. It is found that 2H semiconductor phase with nitrogen doping (N-doping) in flexible gas sensors constructed with Ag electrodes exhibits the highest sensitivity of ≈2500% toward 10 ppm of NO 2 . This sensitivity is ≈17- and 417-folds higher than that of 2H MoS 2 without N-doping, and mixed phases with metallic 1T and semiconductor 2H phase, respectively. Comprehensive experimental investigations reveal mechanisms underlying this record sensitivity, that is, the use of N-doped 2H MoS 2 sensors not only significantly suppresses dark current but also effectively enhances electron transfer to NO 2 molecules. Moreover, density function theory calculations underpin the experimental results, confirming that N 2 H 4 molecules from the precursor solution not only promote phase transition but also enable N-doping during post-treatments, thus boosting sensing capability. This work, for the first time, reveals the synergistic effect of phase modulation and N-doping of MoS 2 , which can be readily used in other flexible electronic applications, advancing MoS 2 -based electronics to a new stage.}, archive = {J_ADVS}, author = {Jiyun Kim and Mengyao Li and Chun-Ho Lin and Long Hu and Tao Wan and Ayad Saeed and Peiyuan Guan and Zijian Feng and Tushar Kumeria and Jianbo Tang and Dawei Su and Tom Wu and Dewei Chu}, doi = {10.1002/advs.202410825}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410825}, shortjournal = {Adv. Sci.}, title = {Synergetic phase modulation and N-doping of MoS2 for highly sensitive flexible NO2 sensors}, volume = {12}, year = {2025}, }
• (2025). Photothermal laser printing of sub-micrometer crystalline ZnO structures. ADVS, 12(4), 2410771. (www)

  @article{ , abstract = {During light-driven 3D additive manufacturing, an object represented in digital form is initially translated into a spatial distribution of light intensity (sequentially or in parallel), which then results in a spatial material distribution. To date, this process typically proceeds by photoexcitation of small functional molecules, leading to photochemically induced crosslinking of soft materials. Alternatively, thermal triggers can be employed, yet thermal processes are often slow and provide only low spatial localization. Nevertheless, sub-micrometer ZnO structures for functional microelectronic devices have recently been laser-printed. Herein, the photothermal laser-printing of ZnO is advanced by i ) introducing single-crystalline rather than amorphous sub-micrometer ZnO shapes that crystallize in the hexagonal ZnO wurtzite structure, ii ) employing dimethyl sulfoxide (DMSO) instead of water, enabling higher local process temperatures without micro-bubble formation, and iii ) using substrates tailored for light absorption and heat management, resolving the challenge of light to heat conversion. Finally, the herein-demonstrated ZnO printing requires no post-processing and is a cleanroom-free technique for the fabrication of crystalline semiconductors.}, archive = {J_ADVS}, author = {Matthias Steurer and Paul Somers and Kristian Kraft and Lukas Grünewald and Steven Kraus and Florian Feist and Bastian Weinert and Erich Müller and Stefanie Dehnen and Claus Feldmann and Yolita M. Eggeler and Christopher Barner-Kowollik and Martin Wegener}, doi = {10.1002/advs.202410771}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410771}, shortjournal = {Adv. Sci.}, title = {Photothermal laser printing of sub-micrometer crystalline ZnO structures}, volume = {12}, year = {2025}, }
• (2025). Effect of lanthanum-aluminum co-doping on structure of hafnium oxide ferroelectric crystals. ADVS, 12(4), 2410765. (www)

  @article{ , abstract = {Hafnium oxide (HfO 2 )-based devices have been extensively evaluated for high-speed and low-power memory applications. Here, the influence of aluminum (Al) and lanthanum (La) co-doping HfO 2 thin films on the ferroelectric characteristics of hafnium-based devices is investigated. Among devices with different La/Al ratios, the Al and La co-doped hafnium oxide (HfAlAO) device with 4.2% Al and 2.17% La exhibited the excellent remanent polarization and thermostability. Meanwhile, first principal analyses verified that hafnium-based thin films with 4.2% Al and 2.17% La promoted the formation of the o-phase against the paraelectric phase, providing theoretical support for supporting experimental results. Furthermore, a vertical ferroelectric HfO 2 memory based on 3D macaroni architecture is reported. The devices show excellent ferroelectric characteristics of 22 µC cm −2 under 4.5 MV cm −1 and minimal coercive field of ≈1.6 V. In addition, the devices exhibit great memory performance, including the response speed of device can achieve 20 ns and endurance characteristic can achieve 10 10 cycles.}, archive = {J_ADVS}, author = {Zhenhai Li and Shuqi Tang and Tianyu Wang and Yongkai Liu and Jialin Meng and Jiajie Yu and Kangli Xu and Ruihong Yuan and Hao Zhu and Qingqing Sun and Shiyou Chen and David Wei Zhang and Lin Chen}, doi = {10.1002/advs.202410765}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410765}, shortjournal = {Adv. Sci.}, title = {Effect of lanthanum-aluminum co-doping on structure of hafnium oxide ferroelectric crystals}, volume = {12}, year = {2025}, }
• (2025). Leveraging interfacial electric field for smart modulation of electrode surface in nitrate to ammonia conversion. ADVS, 12(4), 2410763. (www)

  @article{ , abstract = {The efficiency of nitrate reduction reaction (NO 3 RR) at low nitrate concentration is predominantly hindered by the poor affinity of nitrate ions and competitive hydrogen evolution reaction (HER), particularly in neutral and acidic media. Here, an innovative strategy to leverage the interfacial electric field (IEF) is introduced to boost the NO 3 RR performance. By in situ constructing tannic acid-metal ion (TA-M 2+ ) crosslinked structure on the electrode surface, the TA-M 2+ -CuO NW/Cu foam sample exhibits an exceptional Faraday efficiency of 99.4% at −0.2 V versus reversible hydrogen electrode (RHE) and 83.9% at 0.0 V versus RHE under neutral and acidic conditions, respectively. The computational studies unveil that the TA-Cu 2+ complex on the CuO (111) plane induces the increasing concentration of nitrate at the interface, accelerating NO 3 RR kinetics over HER via the IEF effect. This interfacial modulation strategy also contributes the enhanced ammonia production performance when it is employed on commercial electrode materials and flow reactors, exhibiting great potential in practical application. Overall, combined results illustrated multiple merits of the IEF effect, paving the way for future commercialization of NO 3 RR in the ammonia production industry.}, archive = {J_ADVS}, author = {Kouer Zhang and Yifan Xu and Fatang Liu and Qing Wang and Xiaohong Zou and Mingcong Tang and Michael K.H. Leung and Zhimin Ao and Xunhua Zhao and Xiao Zhang and Liang An}, doi = {10.1002/advs.202410763}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410763}, shortjournal = {Adv. Sci.}, title = {Leveraging interfacial electric field for smart modulation of electrode surface in nitrate to ammonia conversion}, volume = {12}, year = {2025}, }
• (2025). High-throughput single-nucleus RNA profiling of minimal puncture FFPE samples reveals spatiotemporal heterogeneity of cancer. ADVS, 12(4), 2410713. (www)

  @article{ , abstract = {Puncture biopsy, especially those preserved by formalin fixed paraffin embedding (FFPE) samples, play an important role in various research purposes. Diverse single-nucleus RNA sequencing (snRNA-seq) techniques have been developed for FFPE samples, however, how to perform high-throughput snRNA-seq on small FFPE puncture samples is still a challenge. Here, the previously developed snRNA-seq technique (snRandom-seq) is optimized by implementing a pre-indexing procedure for the minimal puncture FFPE samples. In analyzing 20 samples from various solid tumors, optimized snRandom-seq still detected ≈17 000 genes and 12 000 long non-coding RNAs (lncRNAs), achieving precise clustering based on tissue origin. A head-to-head comparison with 10× Genomics on fresh biopsy samples showed a similar gene detection rate, with significantly enhanced lncRNA detection, indicating that the optimized snRandom-seq technique maintains its established gene detection advantages even when applied to small samples. Utilizing 7 puncture FFPE samples of liver metastases from 3 colorectal cancer patients pre- and post-immunotherapy, the cellular developmental trajectories are reconstructed and revealed dynamic spatiotemporal heterogeneity during treatment, including insights into pseudoprogression of immunotherapy. Therefore, the optimized snRandom-seq offers a solution for high-throughput single-cell RNA and non-coding RNA analysis in minimal puncture FFPE sample.}, archive = {J_ADVS}, author = {Weiqin Jiang and Xiang Zhang and Ziye Xu and Qing Cheng and Xiaohan Li and Yuyi Zhu and Fangru Lu and Ling Dong and Linghui Zeng and Weixiang Zhong and Yongcheng Wang and Longjiang Fan and Hongyu Chen}, doi = {10.1002/advs.202410713}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410713}, shortjournal = {Adv. Sci.}, title = {High-throughput single-nucleus RNA profiling of minimal puncture FFPE samples reveals spatiotemporal heterogeneity of cancer}, volume = {12}, year = {2025}, }
• (2025). Understanding the dynamics of sulfur droplets formation in lean-electrolyte and low-temperature Lithium–Sulfur batteries. ADVS, 12(4), 2410628. (www)

  @article{ , abstract = {Lithium–sulfur batteries (LSBs) afford great promises as the next-generation rechargeable batteries due to the high energy density and low cost of sulfur cathodes. Lean-electrolyte condition constitutes the prerequisite for high-energy LSBs, but the insulating sulfur particles hinder capacity utilization, especially at low temperatures. Here, the electrochemical generation of liquid sulfur droplets in the LSB system are studied and elucidate the polysulfide oxidation reaction (SOR) kinetics under different electrolyte/sulfur (E/S) ratios and low-temperature conditions. The real-time observations under in situ optical and Raman microscopies indicate that the formation of liquid sulfur during SOR is independent of the E/S ratio and can be preserved over a wide range of operating temperatures. Quantification of the polysulfide reactant concentrations and the amounts of the liquid sulfur product under different charging conditions reveal pseudo-zero-order kinetics and E/S ratio-dependent reaction constants for the SOR process. In addition, under extreme conditions of −20 °C and E/S ratio of 5 µL mg −1 , liquid sulfur can still be preserved by following the rapid SOR kinetics. These findings provide new insights into the liquid sulfur generation dynamics in Li─S chemistry, which enables a deeper understanding of the effects of the E/S ratio and working temperature on the oxidation kinetics in LSBs.}, archive = {J_ADVS}, author = {Qi Qi and Fangyi Shi and Jingya Yu and Yiyuan Ma and Feiyang Chen and Wei Lv and Wing-Cheung Law and Shu Ping Lau and Zheng-Long Xu}, doi = {10.1002/advs.202410628}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410628}, shortjournal = {Adv. Sci.}, title = {Understanding the dynamics of sulfur droplets formation in lean-electrolyte and low-temperature Lithium–Sulfur batteries}, volume = {12}, year = {2025}, }
• (2025). Upcycling of polyethylene wastes to valuable chemicals over group VIII metal-decorated WO3 nanosheets. ADVS, 12(4), 2410574. (www)

  @article{ , abstract = {Catalytic cracking of polyolefin wastes into valuable chemicals at mild conditions using non-noble metal catalysts is highly attractive yet challenging. Herein it is reported that 2D tungsten trioxide (2D WO 3 ) nanosheets, after decorating with group VIII metal promoters (i.e., Fe, Co, or Ni), convert high-density polyethylene (HDPE) into alkylaromatics and olefins at low temperature and ambient pressure without using any solvent or hydrogen: 2D Ni/WO 3 with abundant Brønsted acidic sites initiates HDPE cracking at a low temperature of 240 °C; 2D Fe/WO 3 with low energy barrier of cyclization achieves a high HDPE conversion to 84.2% liquid hydrocarbons with a selectivity of 30.9% to aromatics at 300 °C. In-situ spectroscopic investigations and supplementary theoretical calculations illustrate that these aromatics are formed through the cyclization of alkene intermediates. These 2D catalysts also display high efficiency in the low-temperature cracking of single-use commercial polyethylene wastes such as packaging bags and bottles. This work has demonstrated the high potential of 2D non-noble metal catalysts in the efficient upcycling of waste polyolefin at mild conditions.}, archive = {J_ADVS}, author = {Qimin Zhou and Weiqiang Gao and Deliang Wang and Yinlong Chang and Hanxi Guan and Khak Ho Lim and Xuan Yang and Pingwei Liu and Wen-Jun Wang and Bo-Geng Li and Qingyue Wang}, doi = {10.1002/advs.202410574}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410574}, shortjournal = {Adv. Sci.}, title = {Upcycling of polyethylene wastes to valuable chemicals over group VIII metal-decorated WO3 nanosheets}, volume = {12}, year = {2025}, }
• (2025). Nerve-inspired optical waveguide stretchable sensor fusing wireless transmission and AI enabling smart tele-healthcare. ADVS, 12(4), 2410395. (www)

  @article{ , abstract = {Flexible strain monitoring of hand and joint muscle movement is recognized as an effective method for the diagnosis and rehabilitation of neurological diseases such as stroke and Parkinson's disease. However, balancing high sensitivity and large strain, improving wearing comfort, and solving the separation of diagnosis and treatment are important challenges for further building tele-healthcare systems. Herein, a hydrogel-based optical waveguide stretchable (HOWS) sensor is proposed in this paper. A double network structure is adopted to allow the HOWS sensor to exhibit high stretchability of the tensile strain up to 600% and sensitivity of 0.685 mV % −1 . Additionally, the flexible smart bionic fabric embedding the HOWS sensor, produced through the warp and weft knitting, significantly enhances wearing comfort. A small circuit board is prepared to enable wireless signal transmission of the designed sensor, thereby improving the daily portability. A speech recognition and human-machine interaction system, based on sensor signal acquisition, is constructed, and the convolutional neural network algorithm is integrated for disease assessment. By integrating sensing, wireless transmission, and artificial intelligence (AI), a smart tele-healthcare system based on HOWS sensors is demonstrated to hold great potential for early warning and rehabilitation monitoring of neurological diseases.}, archive = {J_ADVS}, author = {Tianliang Li and Qian'ao Wang and Zichun Cao and Jianglin Zhu and Nian Wang and Run Li and Wei Meng and Quan Liu and Shifan Yu and Xinqin Liao and Aiguo Song and Yuegang Tan and Zude Zhou}, doi = {10.1002/advs.202410395}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410395}, shortjournal = {Adv. Sci.}, title = {Nerve-inspired optical waveguide stretchable sensor fusing wireless transmission and AI enabling smart tele-healthcare}, volume = {12}, year = {2025}, }
• (2025). MXene−Graphene oxide heterostructured films for enhanced metasurface plasmonic biosensing in continuous glucose monitoring. ADVS, 12(4), 2410376. (www)

  @article{ , abstract = {Non-invasive biosensors have attracted attention for their potential to obtain continuous, real-time physiological information through measurements of biochemical markers, such as one of the most important—glucose, in biological fluids. Although some optical sensing materials are used in non-invasive devices for continuous glucose monitoring (CGM), surface or localized plasmon sensing material are seldom applied in CGM owing to modest sensitivity and bulk sensing apparatus. Herein, a metasurface (MGMSPR) biosensor based on the metasurface plasmon resonance chip modified with heterostructured Ti 3 C 2 MXene−Graphene oxide (MG) is reported, which potentially enables ultra-sensitive glucose detection. The sensor consists of a dual-channel microfluidic device integrated with silver mirror enhanced MGMSPR chips. Not only does it promote the entry of glucose oxidase (GOD) into the internal pores and enhance the stable fixation of GOD in the membrane, but also the integration of MG material provides a high specific surface area and unique electronic properties, thereby significantly enhancing the sensitivity of the MGMSPR sensor. The detection limit of MGMSPR biosensor is 106.8 µ M . This pioneering approach opens new avenues for monitoring physiological parameters and process analytical technology on an optical platform, providing continuous health monitoring and production process control through optical sensors.}, archive = {J_ADVS}, author = {Rui Li and Hongli Fan and Youqian Chen and Shaoping Yin and Gang L. Liu and Yanan Li and Liping Huang}, doi = {10.1002/advs.202410376}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410376}, shortjournal = {Adv. Sci.}, title = {MXene−Graphene oxide heterostructured films for enhanced metasurface plasmonic biosensing in continuous glucose monitoring}, volume = {12}, year = {2025}, }
• (2025). Targeted SPP1 inhibition of tumor-associated myeloid cells effectively decreases tumor sizes. ADVS, 12(4), 2410360. (www)

  @article{ , abstract = {Secreted phosphosprotein 1 (SPP1) High tumor-associated macrophages (TAM) are abundant tumor myeloid cells that are immunosuppressive, pro-tumorigenic, and have a highly negative prognostic factor. Despite this, there is a lack of efficient TAM-specific therapeutics capable of reducing SPP1 expression. Here, on a phenotypic screen is reported to identify small molecule SPP1 modulators in macrophages. Several hits and incorporated them into a TAM-avid systemic nanoformulation are identified. It is shown that the lead compound (CANDI460) can down-regulate SPP1 in vitro and in vivo and lead to tumor remissions in different murine models. These findings are important as they offer a promising avenue for developing novel therapeutic strategies targeting TAM.}, archive = {J_ADVS}, author = {Benan Kartal and Christopher S. Garris and Hyung Shik Kim and Rainer H. Kohler and Jasmine Carrothers and Elias A. Halabi and Yoshiko Iwamoto and Anne-Gaëlle Goubet and Yuxuan Xie and Pratyaksha Wirapati and Mikaël J. Pittet and Ralph Weissleder}, doi = {10.1002/advs.202410360}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410360}, shortjournal = {Adv. Sci.}, title = {Targeted SPP1 inhibition of tumor-associated myeloid cells effectively decreases tumor sizes}, volume = {12}, year = {2025}, }
• (2025). Effects of alkyl spacer length in carbazole-based self-assembled monolayer materials on molecular conformation and organic solar cell performance. ADVS, 12(4), 2410277. (www)

  @article{ , abstract = {Carbazole-based self-assembled monolayer (SAM) materials as hole transport layers (HTL) have led organic solar cells (OSCs) to state-of-the-art photovoltaic performance. Nonetheless, the impact of the alkyl spacer length of SAMs remains inadequately understood. To improve the knowledge, four dichloride-substituted carbazole-based SAMs (from 2Cl-2PACz to 2Cl-5PACz) with spacer lengths of 2–5 carbon atoms is developed. Single crystal analyses reveal that SAMs with shorter spacers exhibit stronger intermolecular interactions and denser packing. The molecular conformation of SAMs significantly impacts their molecular footprint and coverage on ITO. These factors result in the highest coverage of 2Cl-2PACz and the lowest coverage for 2Cl-3PACz on ITO. OSCs based on PM6:L8-BO with 2Cl-2PACz as HTL achieved high efficiencies of 18.95% and 18.62% with and without methanol rinsing of the ITO/SAMs anodes, corresponding to monolayer and multilayer structures, respectively. In contrast, OSCs utilizing the other SAMs showed decreased efficiencies as spacer length increased. The superior performance of 2Cl-2PACz can be attributed to its shorter spacer, which reduces series resistance, hole tunneling distance, and barrier. This work provides valuable insights into the design of SAMs for high-performance OSCs.}, archive = {J_ADVS}, author = {Qiaonan Chen and Kangbo Sun and Leandro R. Franco and Jingnan Wu and Lars Öhrström and Xianjie Liu and Maureen Gumbo and Mailde S. Ozório and C. Moyses Araujo and Guangye Zhang and André Johansson and Ellen Moons and Mats Fahlman and Donghong Yu and Yufei Wang and Ergang Wang}, doi = {10.1002/advs.202410277}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410277}, shortjournal = {Adv. Sci.}, title = {Effects of alkyl spacer length in carbazole-based self-assembled monolayer materials on molecular conformation and organic solar cell performance}, volume = {12}, year = {2025}, }
• (2025). Cost-effective synthesis of Fe5C2 catalyst from nanosized zero-valent iron to achieve efficient photothermocatalytic CO hydrogenation to light olefins. ADVS, 12(4), 2410215. (www)

  @article{ , abstract = {Fe-based catalysts are commonly applied in the process of Fischer−Tropsch synthesis (FTS) to olefins, with Hägg iron carbide (Fe 5 C 2 ) recognized as the primary active phase. However, iron carbonyls, the raw materials for wet chemical synthesis of Fe 5 C 2 , are expensive and toxic, which limits large-scale preparation. Here, a cost-effective and versatile method is proposed for the synthesis of Fe 5 C 2 nanoparticles (NPs) with nanosized zero-valent iron (abbreviated as NZVI, prepared by reducing iron salts or ball-milling iron powder) instead of iron carbonyls, achieving a cost reduction of 76.8%. Experimental characterizations revealed that NZVI obtained from the reduction of iron salts can catalyze the cracking of octadecylamine to form a carbonized atmosphere, thus realizing the phase transition of Fe into Fe 5 C 2 . The optimized Fe 5 C 2 catalyst is employed in the photothermocatalytic FTS process, achieving a light olefins selectivity of 54.2% in hydrocarbons, with a CO conversion of 24.3%. Furthermore, it is proved that the particle size and surface oxide state of NZVI can impact the synthesis of Fe 5 C 2 . This study demonstrates a cost-effective method for the large-scale preparation of the Fe 5 C 2 catalyst.}, archive = {J_ADVS}, author = {Yuqing Xu and Yuan Li and Ruizhe Li and Hua Xu and Shuxin Ouyang and Hong Yuan}, doi = {10.1002/advs.202410215}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410215}, shortjournal = {Adv. Sci.}, title = {Cost-effective synthesis of Fe5C2 catalyst from nanosized zero-valent iron to achieve efficient photothermocatalytic CO hydrogenation to light olefins}, volume = {12}, year = {2025}, }
• (2025). High Quality–Factor All–Dielectric metacavity for Label–Free biosensing. ADVS, 12(4), 2410125. (www)

  @article{ , abstract = {High sensitivity and high quality-factor are crucial for achieving outstanding sensing performance in photonic biosensors. However, strong optical field confinement and high light–biomolecule interactions on photonic surfaces are usually contradictory and challenging to satisfy simultaneously. Here, a distinctive configuration for addressing this issue is reported: embedding a nanophotonic metasurface inside a micro vertical cavity as a meta-channel (metacavity) biosensor. The analyte solution serves as the cavity medium, thereby maximizing the light–analyte interaction. Simulation validation is conducted to optimize the metacavity with high structural robustness and remarkable optical and sensing properties. Large-scale low-cost metacavity biosensors are realized by combining anodic aluminum oxide template technique and wafer bonding. Experimentally, the metacavity biosensor demonstrates a notable quality-factor (maximum 4140) and high bulk refractometric sensitivity (450 nm RIU −1 ), resulting in an unprecedented figure-of-merit (1670 RIU −1 ). Moreover, the metacavity biosensor achieves high surface sensitivity, together with a detection-limit of 119 viral copies mL −1 for label-free severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudovirus sensing, revealing remarkable performance in both bulk and surface sensing.}, archive = {J_ADVS}, author = {Yuqiao Zheng and Jiacheng Sun and Yaqing Ma and Hongyong Zhang and Zhen Cui and Giannis G. Paschos and Xixi Song and Ying Tao and Pavlos Savvidis and Wei Kong and Liaoyong Wen and Sumin Bian and Mohamad Sawan}, doi = {10.1002/advs.202410125}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410125}, shortjournal = {Adv. Sci.}, title = {High Quality–Factor All–Dielectric metacavity for Label–Free biosensing}, volume = {12}, year = {2025}, }
• (2025). Spatial transcriptome and single nucleus transcriptome sequencing reveals tetrahydroxy stilbene glucoside promotes ovarian organoids development through the vegfa-ephb2 pair. ADVS, 12(4), 2410098. (www)

  @article{ , abstract = {Ovarian dysfunction is a major factor leading to female infertility. Understanding how to improve or reshape ovarian function has become an important entry point for preventing and treating female infertility caused by ovarian dysfunction. Here, plant-derived compounds are screened for in vitro activity upon ovarian organoids derived from feeder-free female germline stem cells. Tetrahydroxy stilbene glucoside (TSG) is found to promote the development of ovarian organoids. Single nucleus transcriptome sequencing and spatial transcriptome sequencing are used to establish a comprehensive spatiotemporal map to elucidate the role of TSG in ovarian organoid development, encompassing cell types and subtypes, transcription factors, pseudo-time sequence, and cell communication dynamics. This analysis indicates that TSG promotes ovarian organoid development through the vascular endothelial growth factor A-Eph receptor B2 ligand-receptor pair between granulosa cells and oocytes. This study has enhanced the understanding of the mechanisms of ovarian organoid development, establishes a technical platform for screening compounds for treating infertility and related diseases, and lays a foundation for clinically applying plant-derived compounds.}, archive = {J_ADVS}, author = {Chunlan Mu and Xiaoyong Li and Jiamei Yang and Geng G. Tian and Hepeng Bai and Wenhui Lin and Linhui Wang and Ji Wu}, doi = {10.1002/advs.202410098}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2410098}, shortjournal = {Adv. Sci.}, title = {Spatial transcriptome and single nucleus transcriptome sequencing reveals tetrahydroxy stilbene glucoside promotes ovarian organoids development through the vegfa-ephb2 pair}, volume = {12}, year = {2025}, }
• (2025). GLP-1 receptor agonists alleviate diabetic kidney injury via β-klotho-mediated ferroptosis inhibition. ADVS, 12(4), 2409781. (www)

  @article{ , abstract = {Semaglutide (Smg), a GLP-1 receptor agonist (GLP-1RA), shows renal protective effects in patients with diabetic kidney disease (DKD). However, the exact underlying mechanism remains elusive. This study employs transcriptome sequencing and identifies β -Klotho (KLB) as the critical target responsible for the role of Smg in kidney protection. Smg treatment alleviates diabetic kidney injury by inhibiting ferroptosis in patients, animal models, and HK-2 cells. Notably, Smg treatment significantly increases the mRNA expression of KLB through the activation of the cyclic adenosine monophosphate (cAMP) signaling pathway, specifically through the phosphorylation of protein kinase A (PKA) and cAMP-response element-binding protein (CREB). Subsequently, the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway is activated, reprograming the key metabolic processes of ferroptosis such as iron metabolism, fatty acid synthesis, and the antioxidant response against lipid peroxidation. Suppression of ferroptosis by Smg further attenuates renal inflammation and fibrosis. This work highlights the potential of GLP-1RAs and KLB targeting as promising therapeutic approaches for DKD management.}, archive = {J_ADVS}, author = {Shasha Tian and Saijun Zhou and Weixi Wu and Yao lin and Tongdan Wang and Haizhen Sun and A-Shan-Jiang A-Ni-Wan and Yaru Li and Chongyang Wang and Xiaogang Li and Pei Yu and Yanjun Zhao}, doi = {10.1002/advs.202409781}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409781}, shortjournal = {Adv. Sci.}, title = {GLP-1 receptor agonists alleviate diabetic kidney injury via β-klotho-mediated ferroptosis inhibition}, volume = {12}, year = {2025}, }
• (2025). Interfacial cfDNA enrichment and amplification with on-chip thermoplasmonics for highly sensitive cancerous liquid biopsy. ADVS, 12(4), 2409708. (www)

  @article{ , abstract = {Tumor-derived cell-free DNA (cfDNA) has been exploited as an effective liquid biopsy biomarker for early cancer diagnosis. However, the fragmented and low-abundance nature in circulating blood pose challenges for highly sensitive cfDNA quantification. Herein, a multifunctional plasmonic biosensor termed Interfacial cfDNA Enrichment, Amplification and Sensing with on-chip Thermoplasmonics (INEAST) is developed for cfDNA-based liquid biopsy and lung cancer diagnosis. The INEAST biosensor achieved in situ thermoregulation and label-free cfDNA biosensing by simultaneously harnessing interfacial thermoplasmonics and localized surface plasmon resonance. Typical cfDNA biomarkers, including epidermal growth factor receptor ( EGFR) , tumor protein 53 ( TP53) , phosphatase and tensin homologue deleted on chromosome 10 ( PTEN) , and cyclin-dependent kinase inhibitor ( CDKN2A) , are quantified with detection limits down to femtomolar-level. Through further validation using blood samples from lung cancer patients, the proposed INEAST bioassays demonstrated superior reliability for lung cancer screening, particularly when combined with clinically available tumor-protein metrics. This study demonstrated that the INEAST biosensor enables rapid and sensitive cfDNA quantification, yielding a promising and compatible liquid biopsy for early-stage lung cancer diagnosis.}, archive = {J_ADVS}, author = {Danhua Wang and Linlin Liu and Wenjing Chi and Zhenping Liu and Jiayun Wu and Yirou Liang and Fei He and Ruixiang Zhang and Pengxin Huang and Yunbo Li and Guangyu Qiu}, doi = {10.1002/advs.202409708}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409708}, shortjournal = {Adv. Sci.}, title = {Interfacial cfDNA enrichment and amplification with on-chip thermoplasmonics for highly sensitive cancerous liquid biopsy}, volume = {12}, year = {2025}, }
• (2025). Tumor site-specific in vivo theranostics enabled by microenvironment-dependent chemical transformation and self-amplifying effect. ADVS, 12(4), 2409506. (www)

  @article{ , abstract = {Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor-specific imaging and therapy, few exhibit effective function in vivo. Herein, a probe called TQ-H 2 is designed that can realize robust theranostic effects both in vitro and in vivo. In vitro, TQ-H 2 specifically targets the lysosome and reacts with hydroxyl radical (·OH) to generate TQ-HA, which lights up the cells. TQ-HA generates reactive oxygen species (ROS) under light irradiation, enabling the simultaneous induction and monitoring of apoptosis and ferroptosis in tumor cells. Remarkably, TQ-HA also acts as a self-amplifier, autocatalytically activating TQ-H 2 by generating ·OH under light exposure. This self-amplification aligns with the tumor microenvironment, where TQ-H 2 undergoes chemical transformation, distinguishing tumors from healthy tissue via near-infrared (NIR) fluorescence imaging. Furthermore, ROS generated by TQ-HA effectively kills tumor cells and inhibits tumor growth without harming normal cells. This study offers a promising strategy for targeted tumor theranostics using self-amplifying microenvironment-responsive fluorescent probes.}, archive = {J_ADVS}, author = {Yunfei Zuo and Pei Li and Wen-Jin Wang and Changhuo Xu and Shuting Xu and Herman H. Y. Sung and Jianwei Sun and Guorui Jin and Weiping Wang and Ryan T. K. Kwok and Jacky W. Y. Lam and Ben Zhong Tang}, doi = {10.1002/advs.202409506}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409506}, shortjournal = {Adv. Sci.}, title = {Tumor site-specific in vivo theranostics enabled by microenvironment-dependent chemical transformation and self-amplifying effect}, volume = {12}, year = {2025}, }
• (2025). Non-reciprocity, metastability, and dynamic reconfiguration in co-assembly of active and passive particles. ADVS, 12(4), 2409489. (www)

  @article{ , abstract = {Living organisms often exhibit non-reciprocal interactions where the forces acting on the objects are not equal in magnitude or opposite in direction. The combination of reciprocal and non-reciprocal interactions between synthetic building blocks remains largely unexplored. Here, out-of-equilibrium assemblies of non-motile isotropic passive and metal-patched motile active particles are formed by overlapping bulk interactions with directed self-propulsion. An external alternating current (AC) electric field generates concurrent dipolar and induced-charge electrophoretic forces between the particles which are evaluated using microscopy. The interaction force measurements allow to determine the degree of reciprocity in interactions, which is tunable by designing the active particle and its trajectory. While linearly-propelled active particles evade assembly with passive particles, helically propelled active particles form active-passive clusters with dynamic reconfiguration and long-lived metastability. Large clusters display programmable fluctuations and reconfigurability by controlling the fraction of active particles. The study establishes principles of integrating reciprocal and non-reciprocal interactions in guided colloidal assembly of reconfigurable metastable structures.}, archive = {J_ADVS}, author = {Ahmed Al Harraq and Ruchi Patel and Jin Gyun Lee and Ope Owoyele and Jaehun Chun and Bhuvnesh Bharti}, doi = {10.1002/advs.202409489}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409489}, shortjournal = {Adv. Sci.}, title = {Non-reciprocity, metastability, and dynamic reconfiguration in co-assembly of active and passive particles}, volume = {12}, year = {2025}, }
• (2025). Non-invasive photoacoustic cerebrovascular monitoring of early-stage ischemic strokes in vivo. ADVS, 12(4), 2409361. (www)

  @article{ , abstract = {Early-stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize further treatment strategies, and improve the prognosis. Photoacoustic computed tomography (PACT), a non-invasive imaging modality that captures multiparametric high-resolution images of vessel structures, is well suited for evaluating cerebrovascular structures and their function. Here 3D multiparametric transcranial PACT is implemented to monitor the early stage of a photothrombotic (PT)-stroke model in living rats. New vessels in the PT-induced region are successfully observed using PACT, and these observations are confirmed by histology. Then, using multiparametric PACT, it is found that the SO 2 in the ischemic area decreases while the SO 2 in newly formed vessels increases, and the SO 2 in the PT region also recovers. These findings demonstrate PACT's remarkable ability to image and monitor cerebrovascular morphologic and physiological changes. They highlight the usefulness of whole-brain PACT as a potentially powerful tool for early diagnosis and therapeutic decision-making in treating ischemic stroke.}, archive = {J_ADVS}, author = {Jiwoong Kim and Joo Young Kweon and Seongwook Choi and Hyunseo Jeon and Minsik Sung and Rongkang Gao and Chengbo Liu and Chulhong Kim and Yong Joo Ahn}, doi = {10.1002/advs.202409361}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409361}, shortjournal = {Adv. Sci.}, title = {Non-invasive photoacoustic cerebrovascular monitoring of early-stage ischemic strokes in vivo}, volume = {12}, year = {2025}, }
• (2025). Grain boundaries control lithiation of solid solution substrates in lithium metal batteries. ADVS, 12(4), 2409275. (www)

  @article{ , abstract = {The development of sustainable transportation and communication systems requires an increase in both energy density and capacity retention of Li-batteries. Using substrates forming a solid solution with body-centered cubic Li enhances the cycle stability of anode-less batteries. However, it remains unclear how the substrate microstructure affects the lithiation behavior. Here, a correlative, near-atomic scale probing approach is deployed through combined ion- and electron-microscopy to examine the distribution of Li in Li-Ag diffusion couples as model system mimicking high current densities. It is revealed that Li regions with over 93.8% at.% nucleate within Ag at random high-angle grain boundaries, whereas grain interiors are not lithiated. The role of kinetics and mechanical constraint from the microstructure over equilibrium thermodynamics in dictating the lithiation process is evidenced. The findings suggest that grain size and grain boundary character are critical to enhance the electrochemical performance of interlayers/electrodes, particularly for improving lithiation kinetics and hence reducing dendrite formation.}, archive = {J_ADVS}, author = {Leonardo Shoji Aota and Chanwon Jung and Siyuan Zhang and Ömer K. Büyükuslu and Aparna Saksena and Ezgi Hatipoglu and Poonam Yadav and Mahander Pratap Singh and Xinren Chen and Eric Woods and Christina Scheu and Se-Ho Kim and Dierk Raabe and Baptiste Gault}, doi = {10.1002/advs.202409275}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409275}, shortjournal = {Adv. Sci.}, title = {Grain boundaries control lithiation of solid solution substrates in lithium metal batteries}, volume = {12}, year = {2025}, }
• (2025). Nanosurface-reconstructed fuel electrode by selective etching for highly efficient and stable solid oxide cells. ADVS, 12(4), 2409272. (www)

  @article{ , abstract = {Solid oxide cells (SOCs) are promising energy-conversion devices due to their high efficiency under flexible operational modes. Yet, the sluggish kinetics of fuel electrodes remain a major obstacle to their practical applications. Since the electrochemically active region only extends a few micrometers, manipulating surface architecture is vital to endow highly efficient and stable fuel electrodes for SOCs. Herein, a simple selective etching method of nanosurface reconstruction is reported to achieve catalytically optimized hierarchical morphology for boosting the SOCs under different operational modes simultaneously. The selective etching can create many corrosion pits and exposure of more B-site active atoms in Sr 2 Co 0.4 Fe 1.2 Mo 0.4 O 6-δ fuel electrode, as well as promote the exsolution of CoFe alloy nanoparticles. An outstanding electrochemical performance of the fabricated cell with the power density increased by 1.47 times to 1.31 W cm −2 at fuel cell mode is demonstrated, while the current density reaches 1.85 A cm −2 under 1.6 V at CO 2 electrolysis mode (800 °C). This novel selective etching method in perovskite oxides provides an appealing strategy to fabricate hierarchical electrocatalysts for highly efficient and stable SOCs with broad implications for clean energy systems and CO 2 utilization.}, archive = {J_ADVS}, author = {Yueyue Sun and Jun Zhou and Jiaming Yang and Dragos Neagu and Zhengrong Liu and Chaofan Yin and Zixuan Xue and Zilin Zhou and Jiajia Cui and Kai Wu}, doi = {10.1002/advs.202409272}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409272}, shortjournal = {Adv. Sci.}, title = {Nanosurface-reconstructed fuel electrode by selective etching for highly efficient and stable solid oxide cells}, volume = {12}, year = {2025}, }
• (2025). Interleukin 15-presenting nanovesicles with doxorubicin-loaded ferritin cores for cancer immunochemotherapy. ADVS, 12(4), 2409194. (www)

  @article{ , abstract = {Interleukin 15 (IL15) is crucial for fostering the survival and proliferation of nature killer (NK) cells and cytotoxic T lymphocytes (CTLs), playing a pivotal role in tumor control. However, IL15 supplementary therapy encounters challenges such as systemic inflammation and non-specific stimulation of cancer cells. Herein, a nanovesicle termed DoxFILN, comprising a membrane presenting IL15/IL15 receptor α complexes (IL15c) and a core of doxorubicin-loaded ferritin (Dox-Fn) are reported. The DoxFILN significantly enhances the densities and activities of intratumoral CTLs and NK cells. Mechanistically, DoxFILN undergoes deshelling in the acidic tumor microenvironment, releasing Dox-Fn and membrane-bound IL15c. Dox-Fn selectively target transferrin receptors on cancerous cells, facilitating intracellular Dox release and inducing immunogenic cell death. Concurrently, membrane-bound IL15c recognizes and activates IL15 receptor β/γc heterodimers, leading to a remarkable increase in the proliferation and activation of CTLs (16-fold and 28-fold) and NK cells (37-fold and 50-fold). The IL15-displaying nanovesicle introduced here holds promise as a potential platform for immunochemotherapy in the treatment of cancer.}, archive = {J_ADVS}, author = {Yihui Zhai and Wen Zhang and Jinming Wang and Ying Kong and Rong Rong and Tianqun Lang and Chao Zheng and Yanke Wang and Yang Yu and Helen He Zhu and Ying Cai and Pengcheng Zhang and Yaping Li}, doi = {10.1002/advs.202409194}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409194}, shortjournal = {Adv. Sci.}, title = {Interleukin 15-presenting nanovesicles with doxorubicin-loaded ferritin cores for cancer immunochemotherapy}, volume = {12}, year = {2025}, }
• (2025). Sustainable immunomodulatory via macrophage P2Y12 inhibition mediated bioactive patche for peritendinous antiadhesion. ADVS, 12(4), 2409128. (www)

  @article{ , abstract = {Persistent anti-inflammatory responses are critical for the prevention of peritendinous adhesion. Although modified anti-adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. In this research, the advantage of the multi-functionalities of CA (caffeic acid) is taken to synthesize biodegradable poly (ester urethane) urea elastomers with ester- and carbamate-bonded CA (PEUU-CA). PEUU-CA is electrospun into bioactive patches that can uniquely present a sustained CA niche, referred to as BPSN. In the early stage of degradation, the breakage of the ester bond from BPSN is the dominant factor contributing to the early release of CA. In the later stage of BPSN degradation, the breakage of the ester and carbamate bonds contributes to the sustained release of CA. In vitro experiments showed that CA, when specifically bound to the P2Y12 receptor, down-regulated the expression and function of active P2Y12, effectively inhibiting the aberrant activation of macrophages and the secretion of inflammatory chemokines. BPSN addresses the foreign body reaction induced by macrophage-dominated biomaterial implantation and the issue of the short-term release of drugs at later stages of adhesion, providing a feasible strategy for the prevention and treatment of tissue adhesion, and more broadly, the well-known implant-derived inflammatory responses.}, archive = {J_ADVS}, author = {Zaijin Tao and Shuo Wang and Jingwen Liu and Tonghe Zhu and Jia Jiang and Shen Liu and Xin Ma}, doi = {10.1002/advs.202409128}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409128}, shortjournal = {Adv. Sci.}, title = {Sustainable immunomodulatory via macrophage P2Y12 inhibition mediated bioactive patche for peritendinous antiadhesion}, volume = {12}, year = {2025}, }
• (2025). Thermal management approach to stabilization of disordered active sites for sabatier reaction. ADVS, 12(4), 2409048. (www)

  @article{ , abstract = {The transition metal nanocatalysts containing disordered active sites can potentially achieve efficient Sabatier reactions with high selectivity. However, it remains a challenge to maintain the stability of these active sites in such an exothermic reaction. Here, a thermal management approach is reported to address this challenge. Specifically, an efficient and stable catalytic system is developed by integrating urchin-like Ru nanoparticles with disordered active sites ( d -RuNUs) and multi-walled carbon nanotubes (MWCNTs) as heat transfer framework, which achieves a CH 4 yield of 3.3 mol g −1 h −1 with nearly 100% selectivity in 12 h. The characterizations reveal that the thermal-induced crystallization seriously weakens the adsorption of CO 2 , leading to significant degradation of catalytic performance. The heat transfer simulation confirms that the MWCNTs with high thermal conductivity play a key role in rapidly redistributing the reaction heat, thereby preventing the crystallization of disordered structures. This work elucidates the deactivation mechanism of disordered active sites in exothermic reactions and opens the avenue for local thermal management of non-thermal equilibrium reactions.}, archive = {J_ADVS}, author = {Delong Duan and Di Wu and Hongwei Shou and Chuansheng Hu and Canyu Hu and Min Zhou and Ran Long and Yingpu Bi and Yujie Xiong}, doi = {10.1002/advs.202409048}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2409048}, shortjournal = {Adv. Sci.}, title = {Thermal management approach to stabilization of disordered active sites for sabatier reaction}, volume = {12}, year = {2025}, }
• (2025). Photo-induced synthesis of ytterbium and manganese-doped CsPbCl3 nanocrystals for visible to near-infrared photoluminescence with negative thermal quenching. ADVS, 12(4), 2408927. (www)

  @article{ , abstract = {Rare-earth-doped all-inorganic perovskite applications for near-infrared (NIR) emission are crucial for the construction of the next generation of intelligent lighting sources. However, the preparation of rare-earth-doped all-inorganic perovskite is complex, and difficult to control, and the issue of thermal quenching poses significant challenges to its practical application. Here, in order to address these issues, a convenient photo-induced synthesis method for CsPbCl 3 :Mn/Yb nanocrystals (NCs) is proposed by decomposing carbon tetrachloride with 365 nm light to provide chloride ions and regulate the formation of perovskite at room temperature. The negative thermal quenching in the NIR emission is achieved through the energy transfer between Mn and Yb. The emission intensity of Yb enhances 3.2 times when the temperature rises to ≈427 K. Furthermore, with the help of the orange emission from the Mn 2+ ions and the NIR emission from the Yb 3+ ions, visible to NIR light emitting diode (LED) devices are constructed and applied in orange light illumination and night vision imaging. This study enriches the preparation methods and chemical research on perovskite doping, which may open up new opportunities for the widespread application of perovskite-based materials or device engineering.}, archive = {J_ADVS}, author = {Xiaochen Fang and Zhuo Chen and Mandy Hei Man Leung and Biao Zheng and Liwei Wang and Meng An and Yusuke Asakura and Yusuke Yamauchi and Zhanhui Yuan}, doi = {10.1002/advs.202408927}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408927}, shortjournal = {Adv. Sci.}, title = {Photo-induced synthesis of ytterbium and manganese-doped CsPbCl3 nanocrystals for visible to near-infrared photoluminescence with negative thermal quenching}, volume = {12}, year = {2025}, }
• (2025). Pathological microenvironment-remodeling nanoparticles to alleviate liver fibrosis: Reversing hepatocytes-hepatic stellate cells malignant crosstalk. ADVS, 12(4), 2408898. (www)

  @article{ , abstract = {During the onset and malignant development of liver fibrosis, the pernicious interplay between damaged hepatocytes and activated hepatic stellate cells (HSCs) induce a self-perpetuating vicious cycle, deteriorating fibrosis progression and posing a grave threat to public health. The secretions released by damaged hepatocytes and activated HSCs interact through autocrine or paracrine mechanisms, involving multiple signaling pathways. This interaction creates a harsh microenvironment and weakens the therapeutic efficacy of single-cell-centric drugs. Herein, a malignant crosstalk-blocking strategy is prompted to remodel vicious cellular interplay and reverse pathological microenvironment to put an end to liver fibrosis. Collagenases modified, bardoxolone and siTGF-β co-delivered nanoparticles (C-NPs/BT) are designed to penetrate the deposited collagen barriers and further regulate the cellular interactions through upregulating anti-oxidative stress capacity and eliminating the pro-fibrogenic effects of TGF-β. The C-NPs/BT shows successful remodeling of vicious cellular crosstalk and significant disease regression in animal models. This study presents an innovative strategy to modulate cellular interactions for enhanced anti-fibrotic therapy and suggests a promising approach for treating other chronic liver diseases.}, archive = {J_ADVS}, author = {Ling-Feng Zhang and Wen-Qi Deng and Xing-Huan Wang and Qing-Wen Huang and Su-Qing Liang and Ze-Quan Ding and Liang Qi and Yi Wang and Tian-Jiao Zhou and Lei Xing and Jai-Woo Lee and Yu-Kyoung Oh and Hu-Lin Jiang}, doi = {10.1002/advs.202408898}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408898}, shortjournal = {Adv. Sci.}, title = {Pathological microenvironment-remodeling nanoparticles to alleviate liver fibrosis: Reversing hepatocytes-hepatic stellate cells malignant crosstalk}, volume = {12}, year = {2025}, }
• (2025). Reinterpretation of report of tetrataenite in bulk alloy castings. ADVS, 12(4), 2408796. (www)

  @article{ , abstract = {After the publication of “Direct formation of hard-magnetic tetrataenite in bulk alloy castings” Ivanov et al., Advanced Science 10 (2022) 2204315, the authors identified a potential misinterpretation of the experimental data. Further work confirms that the original conclusions cannot be supported, and accordingly the paper is retracted. X-ray diffraction shows the presence of (Fe,Ni) 3 P, giving additional Bragg peaks that were previously attributed to tetrataenite. Extra Bragg reflections observed in transmission electron diffraction, and earlier considered to be superlattice reflections from tetrataenite, instead result from oxidation of the sample surface during preparation. Measurements of magnetic hysteresis show no regions of high coercivity of the kind expected when tetrataenite is present. It is concluded that as-cast bulk samples of Fe-Ni-P-(C) show no evidence of tetrataenite on any length scale. Nevertheless, the addition of phosphorus should remain of interest in ongoing efforts to manufacture tetrataenite.}, archive = {J_ADVS}, author = {Owain S. Houghton and James C. Loudon and Alison C. Twitchett-Harrison and Nikolaos T. Panagiotopoulos and Giulio I. Lampronti and Miguel B. Costa and Richard J. Harrison and A. Lindsay Greer}, doi = {10.1002/advs.202408796}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408796}, shortjournal = {Adv. Sci.}, title = {Reinterpretation of report of tetrataenite in bulk alloy castings}, volume = {12}, year = {2025}, }
• (2025). Liquid–Solid triboelectric nanogenerator-based DNA barcode detection biosensor for species identification. ADVS, 12(4), 2408718. (www)

  @article{ , abstract = {DNA barcode detection method is widely applied for species identification, which is imperative to evaluate the effect of human economic activities on the biodiversity of ecosystem. However, the wide utilization of existing detection biosensors is limited by bulky and expensive instruments, such as Raman spectroscopy and electrochemical station. Herein, a liquid–solid triboelectric nanogenerator (TENG)-based DNA barcode detection biosensor is proposed, which consists of water flow, fluid channel, and PDMS film attached by specifically designed capture probe. Through sequentially combining capture probe, targeted DNA barcode, and signal probe with Au nanoparticles (NPs), the surface charge density of friction layer of TENG decreases under the effect of AuNPs, verified by the density functional theory (DFT) method. Consequently, the peak value of output current spike signal for targeted DNA is smaller than that for other DNA, which is the working mechanism of the present TENG-based biosensor. Such biosensor successfully recognizes Alvinocaris muricola among different types of Alvinocarididae shrimps, and its low limit detection can reach 1×10 −12 m . The present work provides a paradigm-shift way to develop an inexpensive and accurate technique to detect DNA barcode for species identification, and paves a novel way for the application of liquid–solid TENG.}, archive = {J_ADVS}, author = {Wenlong Ma and Jiawei Li and Xiaolin Qu and Shao‘e Sun and Yanan Zhou and Yitong Liu and Peng Wang and Zhongli Sha}, doi = {10.1002/advs.202408718}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408718}, shortjournal = {Adv. Sci.}, title = {Liquid–Solid triboelectric nanogenerator-based DNA barcode detection biosensor for species identification}, volume = {12}, year = {2025}, }
• (2025). Accurately tunable AuNC-ZIF content architecture based on coordination-dissociation mechanism enables highly brightness dual-site fluorescent biosensor. ADVS, 12(4), 2408400. (www)

  @article{ , abstract = {The quantum yield and fluorescence intensity of gold nanocluster (AuNC) nanocarriers are critical parameters for developing ultrasensitive biosensors. In this study, AuNCs-zeolitic-imidazolate-framework (Au-ZIF) nanocomposites are systematically constructed by impregnating AuNCs onto the ZIF-8 surface through a coordination-dissociation mechanism, resulting in a dual-site fluorescence-loaded structure. In this configuration, AuNCs are anchored to the external surface while the integrity of the inner cavity remains intact. The surface of ZIF-8 induces a confinement effect on the configuration and electrons of AuNCs, significantly enhancing luminescence (18-fold increase). The quantum yield of AuNCs exhibits an increase of more than 13-fold, from 2.80% to 38.1%. This approach demonstrates broad applicability and maintains strong fluorescence across different ZIFs. Additionally, a novel nanocomposite, Au-ZIF@carbon-dots (CDs), is synthesized by encapsulating CDs into the inner cavity of Au-ZIF. A ratiometric fluorescence detection platform is subsequently developed and incorporated into hydrogels for the quantitative detection of the pesticide triazophos. By employing an image-processing algorithm, quantitative detection is achieved with a detection limit of 0.07 ng mL⁻ 1 . The findings provide crucial insights into the relationship between the assembly and performance of AuNCs and ZIFs, offering guidance for designing ultrasensitive multifunctional biosensors applicable in the field of biosensing.}, archive = {J_ADVS}, author = {Junyang Chen and Yuqian Wang and Runpu Shen and Wei Li and Sainan Gao and Zhikang Xiao and Qiyan Lv and Xiaojie Song and Jianzhong Xu and Gaoxiang Xu and Huifang Cui and Zhaohui Li}, doi = {10.1002/advs.202408400}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408400}, shortjournal = {Adv. Sci.}, title = {Accurately tunable AuNC-ZIF content architecture based on coordination-dissociation mechanism enables highly brightness dual-site fluorescent biosensor}, volume = {12}, year = {2025}, }
• (2025). Targeting caveolin-1 in multiple myeloma cells enhances chemotherapy and natural killer cell-mediated immunotherapy. ADVS, 12(4), 2408373. (www)

  @article{ , abstract = {The cell membrane transport capacity and surface targets of multiple myeloma (MM) cells heavily influence chemotherapy and immunotherapy. Here, it is found that caveolin-1 (CAV1), a primary component of membrane lipid rafts and caveolae, is highly expressed in MM cells and is associated with MM progression and drug resistance. CAV1 knockdown decreases MM cell adhesion to stromal cells and attenuates cell adhesion-mediated drug resistance to bortezomib. CAV1 inhibition in MM cells enhances natural killer cell-mediated cytotoxicity through increasing CXCL10, SLAMF7, and CD112. CAV1 suppression reduces mitochondrial membrane potential, increases reactive oxygen species, and inhibits autophagosome-lysosome fusion, resulting in the disruption of redox homeostasis. Additionally, CAV1 knockdown enhances glutamine addiction by increasing ASCT2 and LAT1 and dysregulates glutathione metabolism. As a result of CAV1 inhibition, MM cells are more sensitive to starvation, glutamine depletion, and glutamine transporter inhibition, and grow more slowly in vivo in a mouse model treated with bortezomib. The observation that CAV1 inhibition modulated by 6-mercaptopurine, daidzin, and statins enhances the efficacy of bortezomib in vitro and in vivo highlights the translational significance of these FDA-approved drugs in improving MM outcomes. These data demonstrate that CAV1 serves as a potent therapeutic target for enhancing chemotherapy and immunotherapy for MM.}, archive = {J_ADVS}, author = {Dewen Zhan and Zhimin Du and Shang Zhang and Juanru Huang and Jian Zhang and Hui Zhang and Zhongrui Liu and Eline Menu and Jinheng Wang}, doi = {10.1002/advs.202408373}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408373}, shortjournal = {Adv. Sci.}, title = {Targeting caveolin-1 in multiple myeloma cells enhances chemotherapy and natural killer cell-mediated immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Optical visualization of stretchable serpentine interconnects using chiral liquid crystal elastomers. ADVS, 12(4), 2408346. (www)

  @article{ , abstract = {The shapes and structures of stretchable interconnects are pivotal in determining their functionality, allowing them to withstand bending, stretching, and twisting while maintaining their operational integrity. However, all stretchable interconnects are subjected to dynamically changing, non-uniform strains during mechanical deformation. Therefore, achieving an accurate understanding of stretchable interconnect properties, including tracking and analyzing these dynamic, non-uniform strains in real-time, remains a challenging endeavor. Herein, a method for analyzing the strain behavior of stretchable interconnects using a chiral liquid crystal elastomer (CLCE), which exhibits immediate structural color changes of nano periodic molecular arrangement in response to dynamic stretching deformations, is presented. Beyond the uniform color change of simple CLCE, by further engineering the modulus and shape geometry of the serpentine CLCE, an intuitive strain capturing visualization of dynamically changing serpentine structures is performed. Moreover, by expanding the serpentine CLCE into a 2 × 2 array, the real-time strain distribution of the stretchable interconnects under various multi-stretching properties (uniaxial and biaxial) is investigated. This optical visualization provides an accurate and precise understanding of the structure of stretchable interconnects under dynamic stretching conditions and is a promising breakthrough to enable enhanced design and optimization of stretchable serpentine structures for broadband stretchable applications.}, archive = {J_ADVS}, author = {Sang Hyun Han and Jun Hyuk Shin and Hak Jun Yang and Seungmin Nam and Ji Yoon Park and Su Seok Choi}, doi = {10.1002/advs.202408346}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408346}, shortjournal = {Adv. Sci.}, title = {Optical visualization of stretchable serpentine interconnects using chiral liquid crystal elastomers}, volume = {12}, year = {2025}, }
• (2025). OMP38 of carbapenem-resistant acinetobacter baumannii-mediated mtDNA release activates the cGAS-STING signaling to induce inflammatory response. ADVS, 12(4), 2408292. (www)

  @article{ , abstract = {Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a major threat in the treatment of bacterial infection, and immunotherapy in a non-antibiotic-dependent manner is an effective way to overcome CRAB infection. However, the role of the innate immune response in CRAB infection is poorly understood. Here, it is reported that CRAB infection induced a cytosolic DNA-sensing signaling pathway and significant IFN-β production in mice post-CRAB infection. The knockout of STING reduced bacterial burden, the production of inflammatory cytokines, and lung injury in mice post CRAB infection. The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and the adaptor protein stimulator of interferon genes (STING) are required for CRAB-induced IFN-β expression in macrophages. Intriguingly, CRAB utilized outer membrane vesicles (OMVs) to transport outer membrane protein 38 (OMP38) into mitochondria, triggering mitochondrial DNA (mtDNA) release into the cytosol through the mitochondrial permeability transition pore (mPTP) and activating the cGAS-STING signaling. Finally, epigallocatechin gallate (EGCG) is demonstrated to block the activation of the cGAS-STING pathway and ameliorate CRAB-induced excessive inflammatory response. These results demonstrated that the early innate immune response to CRAB infection is activated in a cGAS-STING-dependent manner, which could be a potential therapeutic target for CRAB infection.}, archive = {J_ADVS}, author = {Yang Yang and Yuanyuan Zeng and Jianjie Zhu and Jianjun Li and Lei Gu and Lin Wei and Zeyi Liu and Jian-an Huang}, doi = {10.1002/advs.202408292}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408292}, shortjournal = {Adv. Sci.}, title = {OMP38 of carbapenem-resistant acinetobacter baumannii-mediated mtDNA release activates the cGAS-STING signaling to induce inflammatory response}, volume = {12}, year = {2025}, }
• (2025). Prognostic value of skull base foramen invasion subclassification in t category modification and induction chemotherapy management for nasopharyngeal carcinoma: Post-hoc analysis of a dual-center retrospective cohort study. ADVS, 12(4), 2408182. (www)

  @article{ , abstract = {Skull base foramen invasion (SBFI) indicates poor prognosis in nasopharyngeal carcinoma (NPC). However, only a few studies systematically assessed the role of SBFIin staging and treatment of NPC. To investigate the prognostic value of SBFI in NPC, a total of 1,752 patients with nonmetastatic NPC from two hospitals (1,320 and 432) between January 2010 and March 2014 are enrolled. The primary endpoint is overall survival (OS). Heatmap/cluster and network analyses are used to provide subclassification indication. Univariate and multivariate analyses with Kaplan–Meier method are performed to compare survival outcomes. SBFIs are classified into slight (only foramen lacerum and/or pterygopalatine fossa invasion) and severe (other SBFIs). The severe SBFI is an unfavorable prognosticator for OS in both the entire cohort and the T3 group. OS is similar between T3 with severe SBFI and T4 patients. Reclassifying T3 with severe SBFI as the T4 category yields an improved T category discrimination. Additionally, patients in the severe SBFI group gain significant survival benefits from induction chemotherapy ((IC). Therefore, T3 NPC with severe SBFI is an independent negative predictor for OS and is classified into the T4 category. T category adjustment enables better prognostic stratification. Severe SBFI benefits from IC in long-term OS.}, archive = {J_ADVS}, author = {Siyu Zhu and Shuqi Li and Di Cao and Chao Luo and Zhiying Liang and Shaobo Liang and Guoyi Zhang and Qin Zhao and Guangying Ruan and Lizhi Liu and Gui Fu and Haojiang Li}, doi = {10.1002/advs.202408182}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408182}, shortjournal = {Adv. Sci.}, title = {Prognostic value of skull base foramen invasion subclassification in t category modification and induction chemotherapy management for nasopharyngeal carcinoma: Post-hoc analysis of a dual-center retrospective cohort study}, volume = {12}, year = {2025}, }
• (2025). Molecular programming design of glyconucleic acid aptamer with high stability. ADVS, 12(4), 2408168. (www)

  @article{ , abstract = {Functional nucleic acids (FNAs), possessing specific biological functions beyond their informational roles, have gained widespread attention in disease therapeutics. However, their clinical application is severely limited by their low serum stability in complex physiological environments. In this work, a precise molecular programming strategy is explored to prepare glyconucleic acid aptamers (GNAAs) with high serum stability. Four glyconucleic acid modules compatible with commercial solid-phase synthesis are designed and synthesized. Through precise molecular design, the accurate modification of four different carbohydrate ligands at specific sites of DNA aptamers is achieved. It is demonstrated that glycosylation modification can significantly increase DNA aptamers’ serum stability while maintaining their structures and high affinity. The stabilization effect is superior to that of currently commonly used commercial chemical modifications. Moreover, it is confirmed that this approach displays insignificant effects on the DNA aptamers’ tumor-targeting ability and metabolism in vivo. This method offers a simple, economical, and efficient strategy for precise glycosylation modification of nucleic acids. This allows to prepare glycosyl functional nucleic acids with high serum stability, which can expand the application scope of functional nucleic acids and promote the practical transformation of functional nucleic acids.}, archive = {J_ADVS}, author = {Yongqi Han and Rongjun Zhang and Hong-Liang Bao and Mei Yang and Yuan Gao and Xiaobo Gao and Ruowen Wang and Weihong Tan and Ding-Kun Ji}, doi = {10.1002/advs.202408168}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408168}, shortjournal = {Adv. Sci.}, title = {Molecular programming design of glyconucleic acid aptamer with high stability}, volume = {12}, year = {2025}, }
• (2025). Highly tunable moiré superlattice potentials in twisted hexagonal boron nitrides. ADVS, 12(4), 2408034. (www)

  @article{ , abstract = {Moiré superlattice of twisted hexagonal boron nitride (hBN) has emerged as an advanced atomically thin van der Waals interfacial ferroelectricity platform. Nanoscale periodic ferroelectric moiré potentials in twisted hBN allow the hosting of remote Coulomb superlattice potentials to adjacent 2D materials. Therefore, the new strategies for engineering moiré length, angle, and potential strength are essential for developing programmable quantum materials. Here, it demonstrates the realization of twisted hBN-based moiré superlattice platforms and visualizes the moiré domains and ferroelectric properties using Kelvin probe force microscopy (KPFM). Also, the regular moiré superlattice in the large area is reported. It offers the possibility to reproduce uniform moiré structures with precise control piezo stage stacking and heat annealing. It demonstrates cumulative multi-ferroelectric polarization and multi-level domains with multiple angle mismatched interfaces. Additionally, it observes the quasi-1D anisotropic moiré domains and show the highest resolution analysis of the local built-in strain between adjacent hBN layers compared to the conventional methods. Furthermore, in-situ manipulation of moiré potential is demonstrated using femtosecond pulse laser, which results in the optical phonon-induced atomic displacement at the hBN moiré interfaces. The results pave the way to develop precisely programmable moiré superlattice platforms and investigate strongly correlated physics.}, archive = {J_ADVS}, author = {Kwanghee Han and Minhyun Cho and Taehyung Kim and Seung Tae Kim and Suk Hyun Kim and Sang Hwa Park and Sang Mo Yang and Kenji Watanabe and Takashi Taniguchi and Vinod Menon and Young Duck Kim}, doi = {10.1002/advs.202408034}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2408034}, shortjournal = {Adv. Sci.}, title = {Highly tunable moiré superlattice potentials in twisted hexagonal boron nitrides}, volume = {12}, year = {2025}, }
• (2025). Solar-driven hydrogen peroxide production via BiVO4-based photocatalysts. ADVS, 12(4), 2407801. (www)

  @article{ , abstract = {Solar hydrogen peroxide (H 2 O 2 ) production has garnered increased research interest owing to its safety, cost-effectiveness, environmental friendliness, and sustainability. The synthesis of H 2 O 2 relies mainly on renewable resources such as water, oxygen, and solar energy, resulting in minimal waste. Bismuth vanadate (BiVO 4 ) stands out among various oxide semiconductors for selective H 2 O 2 production under visible light via direct two-electron oxygen reduction reaction (ORR) and two-electron water oxidation reaction (WOR) pathways. Significant advancements have been achieved using BiVO 4 -based materials in solar H 2 O 2 production over the last decade. This review explores advancements in BiVO 4 -based photocatalysts for H 2 O 2 production, focusing on photocatalytic powder suspension (PS) and photoelectrochemical (PEC) systems, representing the main approaches for heterogenous artificial photosynthesis. An overview of fundamental principles, performance assessment methodologies, photocatalyst and photoelectrode development, and optimization of reaction conditions is provided. While diverse strategies, such as heterojunction, doping, crystal facet engineering, cocatalyst loading, and surface passivation, have proven effective in enhancing H 2 O 2 generation, this review offers insights into their similar and distinct implementations within the PS and PEC systems. The challenges and future prospects in this field are also discussed to facilitate the rational design of high-performing BiVO 4 -based photocatalysts and photoelectrodes for H 2 O 2 generation under visible light.}, archive = {J_ADVS}, author = {Hui Ling Tan and Casandra Hui Teng Chai and Jerry Zhi Xiong Heng and Quyen Vu Thi and Xuelian Wu and Yun Hau Ng and Enyi Ye}, doi = {10.1002/advs.202407801}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2407801}, shortjournal = {Adv. Sci.}, title = {Solar-driven hydrogen peroxide production via BiVO4-based photocatalysts}, volume = {12}, year = {2025}, }
• (2025). Complete genomic landscape reveals hidden evolutionary history and selection signature in asian water buffaloes (Bubalus bubalis). ADVS, 12(4), 2407615. (www)

  @article{ , abstract = {To identify the genetic determinants of domestication and productivity of Asian water buffaloes ( Bubalus bubalis ), 470 genomes of domesticated river and swamp buffaloes along with their putative ancestors, the wild water buffaloes ( Bubalus arnee ) are sequenced and integrated. The swamp buffaloes inherit the morphology of the wild buffaloes. In contrast, most river buffaloes are unique in their morphology, but their genomes cluster with the wild buffaloes. The levels of genomic diversity in Italian river and Indonesian swamp buffaloes decrease at opposite extremes of their distribution range. Purifying selection prevented the accumulation of harmful loss-of-function variants in the Indonesian buffaloes. Genes that evolved rapidly (e.g., GKAP1 ) following differential selections in the river and swamp buffaloes are involved in their reproduction. Genes related to milk production (e.g., CSN2 ) and coat color (e.g., MC1R ) underwent strong selections in the dairy river buffaloes via soft and hard selective sweeps, respectively. The selective sweeps and single-cell RNA-seq data revealed the luminal cells as the key cell type in response to artificial selection for milk production of the dairy buffaloes. These findings show how artificial selection has been driving the evolutionary divergence and genetic differentiation in morphology and productivity of Asian water buffaloes.}, archive = {J_ADVS}, author = {Jingfang Si and Dongmei Dai and Neena Amatya Gorkhali and Mingshan Wang and Sheng Wang and Saroj Sapkota and Ram Chandra Kadel and Amir Sadaula and Aashish Dhakal and Md Omar Faruque and Abdullah Ibne Omar and Eka Meutia Sari and Hidayat Ashari and Muhammad Ihsan Andi Dagong and Marnoch Yindee and Hossam E. Rushdi and Hussein Elregalaty and Ahmed Amin and Mohamed A. Radwan and Lan Doan Pham and W. M. M. P. Hulugalla and G. L. L. Pradeepa Silva and Wei Zheng and Shahid Mansoor and Muhammad Basil Ali and Farhad Vahidi and Sahar Ahmed Al-Bayatti and Alfredo Pauciullo and Johannes A. Lenstra and J. Stuart F. Barker and Lingzhao Fang and Dong-Dong Wu and Jianlin Han and Yi Zhang}, doi = {10.1002/advs.202407615}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2407615}, shortjournal = {Adv. Sci.}, title = {Complete genomic landscape reveals hidden evolutionary history and selection signature in asian water buffaloes (Bubalus bubalis)}, volume = {12}, year = {2025}, }
• (2025). Modulation of biomaterial-associated fibrosis by means of combined physicochemical material properties. ADVS, 12(4), 2407531. (www)

  @article{ , abstract = {Biomaterial-associated fibrosis remains a significant challenge in medical implants. To optimize implant design, understanding the interplay between biomaterials and host cells during the foreign body response (FBR) is crucial. Material properties are known to influence cellular behavior and can be used to manipulate cell responses, but predicting the right combination for the desired outcomes is challenging. This study explores how combined physicochemical material properties impact early myofibroblast differentiation using the Biomaterial Advanced Cell Screening (BiomACS) technology, which assesses hundreds of combinations of surface topography, stiffness, and wettability in a single experiment. Normal human dermal fibroblasts (NHDFs) are screened for cell density, area, and myofibroblast markers α-smooth muscle actin (α-SMA) and Collagen type I (COL1) after 24 h and 7 days of culture, with or without transforming growth factor-beta (TGF-β). Results demonstrated that material properties influence fibroblast behavior after 7 days with TGF-β stimulation, with wettability emerging as the predominant factor, followed by stiffness. The study identified regions with increased cell adhesion while minimizing myofibroblast differentiation, offering the potential for implant surface optimization to prevent fibrosis. This research provides a powerful tool for cell-material studies and represents a critical step toward enhancing implant properties and reducing complications, ultimately improving patient outcomes.}, archive = {J_ADVS}, author = {Lisa E. Tromp and Torben A.B. van der Boon and Roderick H.J. de Hilster and Ruud Bank and Patrick van Rijn}, doi = {10.1002/advs.202407531}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2407531}, shortjournal = {Adv. Sci.}, title = {Modulation of biomaterial-associated fibrosis by means of combined physicochemical material properties}, volume = {12}, year = {2025}, }
• (2025). Large spin hall efficiency and current-induced magnetization switching in ferromagnetic heusler alloy Co2MnAl-based magnetic trilayers. ADVS, 12(4), 2407171. (www)

  @article{ , abstract = {The spin Hall efficiency ( ξ ) is a crucial parameter that evaluates the charge-to-spin conversion capability of a material, and thus materials with higher ξ are highly desirable in spin–orbit torque (SOT) devices. Recent studies have highlighted the use of ferromagnetic materials as robust spin sources, paving the way for the development of more efficient SOT devices. To accelerate this innovation, it is essential to pursue ferromagnetic materials of high ξ . Here the experimental observation of a large spin Hall efficiency is reported in ferromagnetic Heusler alloy Co 2 MnAl (CMA)-based magnetic trilayers. Utilizing the current-induced hysteresis loop shift technique, the spin Hall efficiency is determined to be 0.077 for the B 2-phase and 0.029 for the disordered CMA. Notably, magnetization switching both with and without the application of an external auxiliary magnetic field were achieved in these trilayers. The enhancement of ξ is attributed to the formation of chemical ordering in CMA. These findings provide new avenues for the development of ferromagnet-based SOT devices.}, archive = {J_ADVS}, author = {Mingzhi Wang and Chang Pan and Nian Xie and Xuepeng Qiu and Yufei Li and Lili Lang and Shiqiang Wang and Dashuai Cheng and Weijia Fan and Shi-Ming Zhou and Zhong Shi}, doi = {10.1002/advs.202407171}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2407171}, shortjournal = {Adv. Sci.}, title = {Large spin hall efficiency and current-induced magnetization switching in ferromagnetic heusler alloy Co2MnAl-based magnetic trilayers}, volume = {12}, year = {2025}, }
• (2025). Automatic quantitative analysis of internal quantum efficiency measurements of GaAs solar cells using deep learning. ADVS, 12(4), 2407048. (www)

  @article{ , abstract = {A solar cell's internal quantum efficiency (IQE) measurement reveals critical information about the device's performance. This information can be obtained using a qualitative analysis of the shape of the curve, identifying and attributing current losses such as at the front and rear interfaces, and extracting key electrical and optical performance parameters. However, conventional methods to extract the performance parameters from IQE measurements are often time-consuming and require manual fitting approaches. While several methodologies exist to extract those parameters from silicon solar cells, there is a lack of accessible approaches for non-silicon cell technologies, like gallium arsenide cells, typically limiting the analysis to only the qualitative level. Therefore, this study proposes using a deep learning method to automatically predict multiple key parameters from IQE measurements of gallium arsenide cells. The proposed method is demonstrated to achieve a very high level of prediction accuracy across the entire range of parameter values and exhibits a high resilience for noisy measurements. By enhancing the quantitative analysis of IQE measurements, the method will unlock the full potential of quantum efficiency measurements as a powerful characterization tool for diverse solar cell technologies.}, archive = {J_ADVS}, author = {Zubair Abdullah-Vetter and Brendan Wright and Tien-Chun Wu and Ali Shakiba and Ziv Hameiri}, doi = {10.1002/advs.202407048}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2407048}, shortjournal = {Adv. Sci.}, title = {Automatic quantitative analysis of internal quantum efficiency measurements of GaAs solar cells using deep learning}, volume = {12}, year = {2025}, }
• (2025). Hypoxia induced lnc191 upregulation dictates the progression of esophageal squamous cell carcinoma by activating GRP78/ERK pathway. ADVS, 12(4), 2406674. (www)

  @article{ , abstract = {Hypoxia is a typical hallmark of solid tumors and plays a crucial role in the progression of esophageal squamous cell carcinogenesis (ESCC). Nevertheless, the precise mechanisms underlying the involvement of hypoxia in tumor development remain unclear. In the present study, a novel hypoxia-induced long noncoding RNA (lncRNA) is identified first, lnc191 , which is highly expressed in clinical ESCC tissues and is positively correlated with poor prognosis of ESCC patients. These findings provide evidence that the hypoxia-inducible factor-1α (HIF-1α)-mediated transcriptional activation of lnc191 enhances the growth and metastasis of ESCC cells both in vitro and in vivo. Mechanistically, lnc191 interacts with GRP78 (78-kDa glucose-regulated protein), one of the endoplasmic reticulum chaperone proteins, leading to its translocation to the membrane, where GRP78 binds with EGFR and enhances its phosphorylation (Y845), further activates ERK/MAPK signaling pathway, and thereby in favor of the progression of ESCC. Overall, this data proposes lnc191 as a key driver during the development of ESCC and reveals the participation of the activated GRP78/ERK/MAPK axis in the ESCC progression mediated by lnc191 . These findings indicate the potential of lnc191 as a promising diagnostic biomarker and therapeutic target in ESCC.}, archive = {J_ADVS}, author = {Sisi Wei and Xinyi Fan and Xiaoya Li and Wei Zhou and Zhihua Zhang and Suli Dai and Huilai Lv and Yueping Liu and Baoen Shan and Lianmei Zhao and Qimin Zhan and Yongmei Song}, doi = {10.1002/advs.202406674}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2406674}, shortjournal = {Adv. Sci.}, title = {Hypoxia induced lnc191 upregulation dictates the progression of esophageal squamous cell carcinoma by activating GRP78/ERK pathway}, volume = {12}, year = {2025}, }
• (2025). Wireless modular implantable neural device with one-touch magnetic assembly for versatile neuromodulation. ADVS, 12(4), 2406576. (www)

  @article{ , abstract = {Multimodal neural interfaces open new opportunities in brain research by enabling more sophisticated and systematic neural circuit dissection. Integrating complementary features across distinct functional domains, these multifunctional neural probes have greatly advanced the interrogation of complex neural circuitry. However, introducing multiple functionalities into a compact form factor for freely behaving animals presents substantial design hurdles that complicate the device or require more than one device. Moreover, fixed functionality poses challenges in meeting the dynamic needs of chronic neuroscience inquiry, such as replacing consumable parts like batteries or drugs. To address these limitations, the modular implantable neural device (MIND) is introduced with a one-touch magnetic assembly mechanism. Leveraging the seamless exchange of neural interface modules such as optical stimulation, drug delivery, and electrical stimulation, MIND ensures functional adaptability, reusability, and scalability. The versatile design of MIND will facilitate brain research by enabling simplified access to multiple functional modalities as needed.}, archive = {J_ADVS}, author = {Inho Kang and John Bilbily and Choong Yeon Kim and Chuanqian Shi and Manish K. Madasu and Eun Young Jeong and Kyle E. Parker and Do A Kwon and Bum-Joon Jung and Jae-Soon Yang and Juhyun Lee and Noah D.L. Kabbaj and Wonhee Lee and Jun-Bo Yoon and Ream Al-Hasani and Jianliang Xiao and Jordan G. McCall and Jae-Woong Jeong}, doi = {10.1002/advs.202406576}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2406576}, shortjournal = {Adv. Sci.}, title = {Wireless modular implantable neural device with one-touch magnetic assembly for versatile neuromodulation}, volume = {12}, year = {2025}, }
• (2025). A promising approach to ultra-flexible 1 ah Lithium–Sulfur batteries using oxygen-functionalized single-walled carbon nanotubes. ADVS, 12(4), 2406536. (www)

  @article{ , abstract = {Lithium–sulfur (Li-S) batteries represent a promising solution for achieving high energy densities exceeding 500 Wh kg −1 , leveraging cathode materials with theoretical energy densities up to 2600 Wh kg −1 . These batteries are also cost-effective, abundant, and environment-friendly. In this study, an innovative approach is proposed utilizing highly oxidized single-walled carbon nanotubes (Ox-SWCNTs) as a conductive fibrous scaffold and functional interlayer in sulfur cathodes and separators, respectively, to demonstrate large-area and ultra-flexible Li-S batteries with enhanced energy density. The free-standing sulfur cathodes in the Li-S cells exhibit high energy density maintaining 806 mAh g −1 even after 100 charge-discharge cycles. Additionally, oxygen-containing functional groups on the SWCNTs significantly improve electrochemical performance by promoting the adsorption of lithium polysulfides. Employing Ox-SWCNTs in both cathodes and interlayers, the study achieves high-capacity Li-S pouch cells that consistently deliver a capacity of 1.06 Ah and a high energy density of 909 mAh g −1 over 50 charge-discharge cycles. This strategy not only significantly enhances the electrochemical performance of Li-S batteries but also maintains excellent mechanical flexibility under severe deformation, positioning this Ox-SWCNT-based architecture as a viable, light-weight, and ultra-flexible energy storage solution suitable for commercializing rechargeable Li-S batteries.}, archive = {J_ADVS}, author = {Junyoung Heo and Jeong-Won Hong and Ha Won Gu and Junghwan Sung and Dong-Hee Kim and Jung Hoon Kim and Sung Kang and You-Jin Lee and Hye Young Choi and Doohun Kim and Kang-Jun Baeg and Joong Tark Han and Jun-Woo Park}, doi = {10.1002/advs.202406536}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2406536}, shortjournal = {Adv. Sci.}, title = {A promising approach to ultra-flexible 1 ah Lithium–Sulfur batteries using oxygen-functionalized single-walled carbon nanotubes}, volume = {12}, year = {2025}, }
• (2025). Tailoring borate mediator species enables industrial CO production with improved overall energy efficiency by sustainable molten salt CO2 electrolysis. ADVS, 12(4), 2406457. (www)

  @article{ , abstract = {The electrochemical conversion of CO 2 into CO represents a promising strategy for mitigating excessive global greenhouse gas emissions. Nevertheless, achieving industrial-scale electrochemical CO 2 -to-CO conversion with enhanced selectivity and reduced energy consumption presents significant challenges. In this study, a borate-enhanced molten salt process for CO 2 capture and electrochemical transformation is employed, achieving over 98% selectivity for CO and over 55% energy efficiency without the necessity for complex and costly electrocatalysts. Cathodic CO 2 electro-reduction (CO 2 ER) with the anodic oxygen evolution reaction (OER) at an overall current density of 500 mA cm −2 using non-nanostructured transition-metal plate electrodes at 650 °C is coupled. By regulating the electrolyte's oxo-basicity with earth-abundant borax (Na 2 B 4 O 7 ), a borate-enhanced electrolyte is established that accelerates the overall electrochemical reaction efficiently. This system involved a series of well-designed target borate species (BO 3 3− , BO 2 − , and B 4 O 7 2− ) that acted as mediators shuttling between the cathode and anode, favoring CO as the primary cathodic product. Manipulating the atmosphere above the anode facilitated a spontaneous transformation of borates, further enhancing OER performance with long-term operational stability over a cumulative period of 50 h, while also reducing overall energy consumption. This work presents a cost-effective strategy for the industrial-scale production of CO derived from CO 2 , contributing to a lower carbon footprint by establishing a sustainable borate-mediated closed loop.}, archive = {J_ADVS}, author = {Xinyu Li and Bowen Deng and Kaifa Du and Wenmiao Li and Di Chen and Xin Qu and Fangzhao Pang and Xiaodan Zhang and Hao Zha and Huayi Yin and Dihua Wang}, doi = {10.1002/advs.202406457}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2406457}, shortjournal = {Adv. Sci.}, title = {Tailoring borate mediator species enables industrial CO production with improved overall energy efficiency by sustainable molten salt CO2 electrolysis}, volume = {12}, year = {2025}, }
• (2025). Ultra-broad emission copper halide scintillator-based X-ray imager. ADVS, 12(4), 2405995. (www)

  @article{ , abstract = {Lead-free metal-halide scintillators are gaining considerable attention as more eco-friendly and superior alternatives to their lead-based counterparts. However, novel broad-emission band scintillators like the state-of-the-art CsI: Tl scintillator, which can generate high signals due to its strong compatibility with the spectral responsivity of regular photodiode arrays, are still less investigated. Herein, a TPA 2 Cu 2 I 4 (TPACI) copper halide scintillator with a unique ultra-broad emission (FWHM > 240 nm) is developed, which shows universal compatibility with the peak response range of commercial photodetector. The optical properties characterization and mechanism analysis indicates that this ultra-broad spectrum can be attributed to the dual self-trapped exciton (STE) emission consisting of two emission bands. Benefiting from the large Stokes shift and ultra-broad emission band enabled by the dual STE, the self-absorption-free TPACI scintillator exhibits efficient white light emission with a high photoluminescence quantum yields of 94.27%, a high light yield of ≈40124 photons MeV −1 . Moreover, a prototype of a TPACI scintillator-based X-ray imager is assembled for inspecting the internal structures of biological and electronic devices, which demonstrated a high resolution of 5.5 lp mm −1 at modulation transfer function = 0.2. These findings provide insights into the design of efficient, broad-emission scintillators for high-resolution X-ray imaging.}, archive = {J_ADVS}, author = {Haocheng Lv and Wenyi Shao and Haifeng Chen and Guoyang Zhu and Yao Wang and Zhenzhong Zhang and Hongwei Liang}, doi = {10.1002/advs.202405995}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2405995}, shortjournal = {Adv. Sci.}, title = {Ultra-broad emission copper halide scintillator-based X-ray imager}, volume = {12}, year = {2025}, }
• (2025). Systematic characterization of splicing dysregulation in pan solid tumor transcriptome. ADVS, 12(4), 2405626. (www)

  @article{ , abstract = {Splicing dysregulation arising from spliceosomal mutations contributes to disease progression and treatment resistance, mostly in hematologic malignancy. Whereas spliceosomal mutations are less common in solid tumors, splicing disorders are pervasive and proven to promote tumorigenesis. However, there is a lack of systematic understanding of the overall splicing dysregulation patterns and how widespread different patterns occur within or across solid tumor lineage. To address these questions, a computational method called SMNPLS (Sparse Multi-Network Regularized Partial Least Squares) is developed to uncover the pan-cancer splicing dysregulation landscape by extracting joint modular patterns from paired matrices of splicing factors (SFs) expressions and alternative splicing events (ASEs). Six unique patterns illustrated by ASE-SF co-modules are summarized, which involve 1,570 ASEs and altered expression of 170 SFs, covering 40% of TCGA solid tumors. Cross-cancer commonalities of splicing dysregulation are observed among digestive system neoplasms, renal-associated tumors, and urogenital tumors. By contrast, brain tumors demonstrate a distinct splicing pattern with the highest ASE-SF correlation. In addition, some new splicing regulatory relationships are identified that are potentially oncogenic. Overall, the study characterizes the full spectrum of splicing dysregulation patterns, indicating the similarity and specificity of splicing-derived pathogenesis across 31 human solid tumors.}, archive = {J_ADVS}, author = {Jingru Sui and Dan Guo and Xiao Wen and Lei Zhou and Yue Huang and Haoyu Yu and Jinyu Chen and Zhaoqi Liu}, doi = {10.1002/advs.202405626}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2405626}, shortjournal = {Adv. Sci.}, title = {Systematic characterization of splicing dysregulation in pan solid tumor transcriptome}, volume = {12}, year = {2025}, }
• (2025). RNA polymerase RPOTp is involved in C-to-U RNA editing at multiple sites in arabidopsis chloroplasts. ADVS, 12(4), 2405131. (www)

  @article{ , abstract = {RPOTp is the nuclear-encoded plastid-targeted RNA polymerase and plays a crucial role in chloroplast gene expression. Transcripts in plant organelles are altered by the conversion of cytidine (C) to uridine (U) at specific positions through RNA editing. However, whether RPOTp is involved in chloroplast RNA editing remains unclear. Here, the role of RPOTp in C-to-U RNA editing at multiple sites in Arabidopsis chloroplasts is uncovered. Multiple organellar RNA editing factor 2 (MORF2) is required for the editing of most sites in chloroplasts. RPOTp is identified from the co-immunoprecipitation targets of MORF2. The sca3-2 mutant, defective in RPOTp, exhibits a pale-yellow phenotype and alters the RNA editing of nine sites in chloroplasts. It is also shown that RNA editing is uncoupled from chloroplast transcriptional activity. RPOTp directly interacts with chloroplast multiple-site RNA editing factors, including MORF2, MORF8, MORF9, and ORRM1. It is further shown that RPOTp participates in RNA editing by influencing the dimerization of MORF proteins. The defect in RPOTp impairs the expression of most chloroplast genes, indicating an indispensable role for RPOTp in chloroplast gene expression. These findings reveal that RPOTp not only participates in transcription but also has a novel role in RNA editing of chloroplast transcripts.}, archive = {J_ADVS}, author = {Nadia Ahmed Ali and Wenjian Song and Yayi Zhang and Jiani Xing and Kexing Su and Xingxing Sun and Yujia Sun and Yizhou Jiang and Dianxing Wu and Xiaobo Zhao}, doi = {10.1002/advs.202405131}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2405131}, shortjournal = {Adv. Sci.}, title = {RNA polymerase RPOTp is involved in C-to-U RNA editing at multiple sites in arabidopsis chloroplasts}, volume = {12}, year = {2025}, }
• (2025). Precision adverse drug reactions prediction with heterogeneous graph neural network. ADVS, 12(4), 2404671. (www)

  @article{ , abstract = {Accurate prediction of Adverse Drug Reactions (ADRs) at the patient level is essential for ensuring patient safety and optimizing healthcare outcomes. Traditional machine learning-based methods primarily focus on predicting potential ADRs for drugs, but they often fall short of capturing the complexity of individual demographics and the variations in ADRs experienced by different people. In this study, a novel framework called Precise Adverse Drug Reaction (PreciseADR) for patient-level ADR prediction is proposed. The approach effectively integrates relations between patients and ADRs, and harnesses the power of heterogeneous Graph Neural Networks (GNNs) to address the limitations of traditional methods. Specifically, a heterogeneous graph representation of patients is constructed, encompassing nodes that represent patients, diseases, drugs, and ADRs. By leveraging edges in the graph, crucial connections are captured such as a patient being affected by diseases, taking specific drugs, and experiencing ADRs. Next, a GNN-based model is utilized to learn latent representations of the patient nodes and facilitate the propagation of information throughout the graph structure. By employing patient embeddings that consider their diseases and drugs, potential ADRs can be accurately predicted. The PreciseADR is dedicated to effectively capturing both local and global dependencies within the heterogeneous graph, allowing for the identification of subtle patterns and interactions that play a significant role in ADRs. To evaluate the performance of the approach, extensive experiments are conducted on a large-scale real-world healthcare dataset with adverse reports from the FDA Adverse Event Reporting System (FAERS). Experimental results demonstrate that the PreciseADR achieves superior predictive performance in identifying patient-level ADRs, surpassing the strongest baseline by 3.2% in AUC score and by 4.9% in Hit@10.}, archive = {J_ADVS}, author = {Yang Gao and Xiang Zhang and Zhongquan Sun and Payal Chandak and Jiajun Bu and Haishuai Wang}, doi = {10.1002/advs.202404671}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2404671}, shortjournal = {Adv. Sci.}, title = {Precision adverse drug reactions prediction with heterogeneous graph neural network}, volume = {12}, year = {2025}, }
• (2025). Epitranscriptomic RNA m6A modification in cancer therapy resistance: Challenges and unrealized opportunities. ADVS, 12(4), 2403936. (www)

  @article{ , abstract = {Significant advances in the development of new cancer therapies have given rise to multiple novel therapeutic options in chemotherapy, radiotherapy, immunotherapy, and targeted therapies. Although the development of resistance is often reported along with temporary disease remission, there is often tumor recurrence of an even more aggressive nature. Resistance to currently available anticancer drugs results in poor overall and disease-free survival rates for cancer patients. There are multiple mechanisms through which tumor cells develop resistance to therapeutic agents. To date, efforts to overcome resistance have only achieved limited success. Epitranscriptomics, especially related to m 6 A RNA modification dysregulation in cancer, is an emerging mechanism for cancer therapy resistance. Here, recent studies regarding the contributions of m 6 A modification and its regulatory proteins to the development of resistance to different cancer therapies are comprehensively reviewed. The promise and potential limitations of targeting these entities to overcome resistance to various anticancer therapies are also discussed.}, archive = {J_ADVS}, author = {Mohammad Burhan Uddin and Zhishan Wang and Chengfeng Yang}, doi = {10.1002/advs.202403936}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2403936}, shortjournal = {Adv. Sci.}, title = {Epitranscriptomic RNA m6A modification in cancer therapy resistance: Challenges and unrealized opportunities}, volume = {12}, year = {2025}, }
• (2025). Co-translational deposition of n6-acetyl-L-lysine in nascent proteins contributes to the acetylome in mammalian cells. ADVS, 12(4), 2403309. (www)

  @article{ , abstract = {N 6 -acetyl- L - lysine residue is abundant in dietary protein but little is known about its potential influences on the diet-consumers. Herein, it is reported that Lysyl-tRNA synthetase (KARS) mediates co-translational deposition of diet-derived N 6 -acetyl- L -lysine (AcK) in nascent proteins to contribute to the acetylome in cells. Acetylated dietary protein is a direct source of AcK that can widely and substantially regulate the acetylome in multiple organs of mice. By analyzing the mechanisms underlying AcK contributing to the acetylome in mammalian cells, it is found that KARS can utilize AcK as an alternative substrate to produce N 6 -acetyl- l -lysyl-tRNA. The crystal structure of KARS in complex with AcK at 2.26 Å resolution shows that AcK shares the same substrate-binding pocket as L -lysine, allowed by a sidechain flip of Tyr499. The generated N 6 -acetyl- L -lysyl-tRNA introduces AcK into growing nascent polypeptide and results in protein acetylation, including the regions buried inside folded proteins that are post-translational modification (PTM)-inaccessible and functionally important. This undocumented protein modification mechanism is inherently different from PTM and termed as co-translational modification (coTM). It is expected to extend the repertoire of acetylome and improve the understanding of protein modification mechanisms in cells.}, archive = {J_ADVS}, author = {Dingyuan Guo and Nan Li and Xiaoyan Zhang and Runxin Zhou and Jie He and Xiao-Ping Ding and Weixing Yu and Fuqiang Tong and Sibi Yin and Yu Wang and Xin Xu and Long Wang and Mingzhu Fan and Shan Feng and Ke Liu and Ke Tang and Zhuqing Ouyang and Yusong R Guo and Yugang Wang}, doi = {10.1002/advs.202403309}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2403309}, shortjournal = {Adv. Sci.}, title = {Co-translational deposition of n6-acetyl-L-lysine in nascent proteins contributes to the acetylome in mammalian cells}, volume = {12}, year = {2025}, }
• (2025). Smad1 promotes tumorigenicity and chemoresistance of glioblastoma by sequestering p300 from p53. ADVS, 12(4), 2402258. (www)

  @article{ , abstract = {Acetylation is critically required for p53 activation, though it remains poorly understood how p53 acetylation is regulated in glioblastoma (GBM). This study reveals that p53 acetylation is a favorable prognostic marker for GBM, regardless of p53 status, and that Smad1, a key negative regulator of p53 acetylation, is involved in this process. Smad1 forms a complex with p53 and p300, inhibiting p300's interaction with p53 and leading to reduced p53 acetylation and increased Smad1 acetylation in GBM. This results in enhanced tumor growth and resistance to chemotherapy, particularly in tumors with missense mutant p53. Acetylation of K373 is found to be essential for Smad1's oncogenic function but does not confer chemoresistance in the absence of p53. Through molecular docking, it is discovered that Smad1 and p53 both interact with the acetyltransferase domain of p300, but at different amino acid sites. Disturbing the interface of Smad1 through amino acid mutations abolishes the Smad1-p300 complex and promotes p53 acetylation. Therefore, a small molecule is identified through virtual screening that specifically disrupts the Smad1-p300 interaction, offering a promising strategy for inhibiting GBM and increasing chemosensitivity by inhibiting Smad1 acetylation and restoring p53 acetylation.}, archive = {J_ADVS}, author = {Lingli Gong and Daxing Xu and Kaixiang Ni and Jie Li and Wei Mao and Bo Zhang and Zhening Pu and Xiangming Fang and Ying Yin and Li Ji and Jingjing Wang and Yaling Hu and Jiao Meng and Rui Zhang and Jiantong Jiao and Jian Zou}, doi = {10.1002/advs.202402258}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2402258}, shortjournal = {Adv. Sci.}, title = {Smad1 promotes tumorigenicity and chemoresistance of glioblastoma by sequestering p300 from p53}, volume = {12}, year = {2025}, }
• (2025). GFRα1 promotes axon regeneration after peripheral nerve injury by functioning as a ligand. ADVS, 12(4), 2400812. (www)

  @article{ , abstract = {The neurotrophic factor, Glial cell line derived neurotrophi factor (GDNF), exerts a variety of biological effects through binding to its receptors, GDNF family receptor alpha-1 (GFRα1), and RET. However, the existence of cells expressing GFRα1 but not RET raises the possibility that GFRα1 can function independently from RET. Here, it is shown that GFRα1 released from repair Schwann cells (RSCs) functions as a ligand in a GDNF-RET-independent manner to promote axon regeneration after peripheral nerve injury (PNI). Local administration of GFRα1 into injured nerve promoted axon regeneration, even more when combined with GDNF blockade. GFRα1 bound to a receptor complex consisting of NCAM and integrin α7β1 of dorsal root ganglion neurons in a GDNF-RET independent manner. This is further confirmed by the Ret Y1062F knock-in mice, which cannot transmit most of GDNF-RET signaling. Finally, local administration of GFRα1 into injured sciatic nerve promoted functional recovery. These findings reveal a novel role of GFRα1 as a ligand, the molecular mechanism supporting axon regeneration by RSCs, and a novel therapy for peripheral nerve repair.}, archive = {J_ADVS}, author = {Tomoaki Suzuki and Ken Kadoya and Takeshi Endo and Miwako Yamasaki and Masahiko Watanabe and Norimasa Iwasaki}, doi = {10.1002/advs.202400812}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2400812}, shortjournal = {Adv. Sci.}, title = {GFRα1 promotes axon regeneration after peripheral nerve injury by functioning as a ligand}, volume = {12}, year = {2025}, }
• (2025). The arabidopsis RING-type e3 ligase TEAR4 controls seed germination by targeting RGA for degradation. ADVS, 12(4), 2400116. (www)

  @article{ , abstract = {Light and DELLA proteins are central factors controlling seed germination which is critical for seed plant survival and agricultural production. However, the mechanisms underlying DELLA degradation under different light conditions during seed germination remain to be clarified. Here, it is reported that TIE1-ASSOCIATED RING-TYPE E3 LIGASE4 (TEAR4) and other TEARs redundantly promote DELLA degradation to positively regulate seed germination in Arabidopsis. The tear1/2/3/4/5/6 sextuple mutant displayed delayed seed germination under the white or PhyB-dependent light condition, and nearly no seed germination under the PhyA-dependent light condition. The DELLA protein REPRESSOR OF ga1-3 (RGA) accumulated in tear1/2/3/4/5/6 , and disruption of RGA and GA-INSENSITIVE ( GAI ) in tear1/2/3/4/5/6 rescued defective seed germination. Far-red (FR) light rapidly induced TEARs , and TEAR4 is shown to act as an E3 ligase. It is showed that both GA-dependent and TEAR-mediated DELLA degradation pathways are indispensable for PhyA-dependent germination. It is found that TEAR homologs PpTEAR1 and PpTEAR2 from the moss Physcomitrium patens interacted with Arabidopsis DELLAs to promote their degradation, and overexpression of PpTEAR1 or PpTEAR2 completely rescued defective PhyA-dependent seed germination in phya-211 . This findings demonstrate that TEARs act as critical players in fine-tuning seed germination, and TEAR-mediated DELLA degradation might be an ancient pathway conserved in plant kingdom.}, archive = {J_ADVS}, author = {Hao Yu and Yutao Wang and Yi Wang and Xing Wang Deng and Genji Qin}, doi = {10.1002/advs.202400116}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2400116}, shortjournal = {Adv. Sci.}, title = {The arabidopsis RING-type e3 ligase TEAR4 controls seed germination by targeting RGA for degradation}, volume = {12}, year = {2025}, }
• (2025). Biomimetic versatile anisotropic, electroactive cellulose hydrogel scaffolds tailored from fern stem serving as nerve conduit and cardiac patch. ADVS, 12(4), 2400002. (www)

  @article{ , abstract = {Peripheral nerve injury (PNI) and myocardial infarction (MI) are the two most clinically common soft excitable tissue injuries. Both nerve and cardiac tissues exhibit structural anisotropy and electrophysiological activity, providing a wide range of biophysical cues for cell and tissue repair. However, balancing microstructural anisotropy, electroactivity, and biocompatibility is challenging. To address this issue, Dicranopteris linearis ( D. linearis ) is proposed as a low-perceived value fern plant. Moreover, to enhance its usefulness, it can be designed into a tubular structure and a lamellar structure to bridge the damaged tissue. Therefore, a robust yet simple top-down approach is proposed to designing and fabricating the desired biomimetic versatile hydrogels orienting from the D. linearis to customize for different soft excitable tissue repair applications. These anisotropic electroactive hydrogels performed well as nerve guidance conduits (NGC) and engineered cardiac patches (ECP) in the repair of PNI and MI, respectively. Two birds, one stone. Accordingly, the biomimetic strategy of D. linearis to NGC and D. linearis to ECP is first proposed, opening a new horizon for constructing tissue engineering using natural sources.}, archive = {J_ADVS}, author = {Qinghui Liang and Shuhui Chen and Shaofeng Hua and Weihong Jiang and Jiamian Zhan and Chunyi Pu and Rurong Lin and Yutong He and Honghao Hou and Xiaozhong Qiu}, doi = {10.1002/advs.202400002}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2400002}, shortjournal = {Adv. Sci.}, title = {Biomimetic versatile anisotropic, electroactive cellulose hydrogel scaffolds tailored from fern stem serving as nerve conduit and cardiac patch}, volume = {12}, year = {2025}, }
• (2025). Chronic stress-induced and tumor derived SP1+ exosomes polarizing IL-1β+ neutrophils to increase lung metastasis of breast cancer. ADVS, 12(4), 2310266. (www)

  @article{ , abstract = {Chronic stress can significantly promote breast cancer progression. When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced and modified. However, whether tumor-derived exosomes (TDEs) are influenced by chronic stress and participate in chronic stress-mediated distant metastasis remains unclear. Here, it is shown that chronic stress remarkably facilitates the secretion of TDEs and modifies the contents of exosomes by activating the adrenergic β receptor in 4T1 tumor-bearing mice. Exosomes injection and blockade experiments indicate that exosomes play a crucial role in chronic stress-mediated lung metastasis of breast cancer. Chronic stress-induced TDEs are internalized by pulmonary neutrophils and strengthen neutrophil recruitment via the CXCL2 autocrine. In addition, the level of SP1 in TDEs increases, which favors the secretion of IL-1β by neutrophils through the activation of the TLR4-NFκβ pathway, ultimately aggravating lung metastasis of breast cancer. Collectively, this study provides a novel mechanism by which neutrophils within a pre-metastatic niche acquire their inflamed phenotype and establishes an important link among neuroendocrine changes, exosomes, immunity, and metastasis.}, archive = {J_ADVS}, author = {Leyi Zhang and Jun Pan and Meijun Wang and Jini Yang and Sangsang Zhu and Lili Li and Xiaoxiao Hu and Zhen Wang and Liwei Pang and Peng Li and Fang Jia and Guohong Ren and Yi Zhang and Danying Xu and Fuming Qiu and Jian Huang}, doi = {10.1002/advs.202310266}, journal = {Advanced Science}, month = {1}, number = {4}, pages = {2310266}, shortjournal = {Adv. Sci.}, title = {Chronic stress-induced and tumor derived SP1+ exosomes polarizing IL-1β+ neutrophils to increase lung metastasis of breast cancer}, volume = {12}, year = {2025}, }
• (2025). Control of cellular differentiation trajectories for cancer reversion (Adv. sci. 3/2025). ADVS, 12(3), 2570019. (www)

  @article{ , archive = {J_ADVS}, author = {Jeong-Ryeol Gong and Chun-Kyung Lee and Hoon-Min Kim and Juhee Kim and Jaeog Jeon and Sunmin Park and Kwang-Hyun Cho}, doi = {10.1002/advs.202570019}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2570019}, shortjournal = {Adv. Sci.}, title = {Control of cellular differentiation trajectories for cancer reversion (Adv. sci. 3/2025)}, volume = {12}, year = {2025}, }
• (2025). Lipid nanoparticles with fine-tuned composition show enhanced colon targeting as a platform for mRNA therapeutics (Adv. sci. 3/2025). ADVS, 12(3), 2570017. (www)

  @article{ , archive = {J_ADVS}, author = {Riccardo Rampado and Gonna Somu Naidu and Olga Karpov and Meir Goldsmith and Preeti Sharma and Assaf Ezra and Lior Stotsky and Dor Breier and Dan Peer}, doi = {10.1002/advs.202570017}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2570017}, shortjournal = {Adv. Sci.}, title = {Lipid nanoparticles with fine-tuned composition show enhanced colon targeting as a platform for mRNA therapeutics (Adv. sci. 3/2025)}, volume = {12}, year = {2025}, }
• (2025). Vector-free deep tissue targeting of DNA/RNA therapeutics via single capacitive discharge conductivity-clamped gene electrotransfer (Adv. sci. 3/2025). ADVS, 12(3), 2570016. (www)

  @article{ , archive = {J_ADVS}, author = {Jeremy L. Pinyon and Georg von Jonquieres and Stephen L. Mow and Amr Al Abed and Keng-Yin Lai and Mathumathi Manoharan and Edward N. Crawford and Stanley H. Xue and Sarah Smith-Moore and Lisa J. Caproni and Sarah Milsom and Matthias Klugmann and Nigel H. Lovell and Gary D. Housley}, doi = {10.1002/advs.202570016}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2570016}, shortjournal = {Adv. Sci.}, title = {Vector-free deep tissue targeting of DNA/RNA therapeutics via single capacitive discharge conductivity-clamped gene electrotransfer (Adv. sci. 3/2025)}, volume = {12}, year = {2025}, }
• (2025). Iono–Magnonic reservoir computing with chaotic spin wave interference manipulated by ion-gating (Adv. sci. 3/2025). ADVS, 12(3), 2570015. (www)

  @article{ , archive = {J_ADVS}, author = {Wataru Namiki and Daiki Nishioka and Yuki Nomura and Takashi Tsuchiya and Kazuo Yamamoto and Kazuya Terabe}, doi = {10.1002/advs.202570015}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2570015}, shortjournal = {Adv. Sci.}, title = {Iono–Magnonic reservoir computing with chaotic spin wave interference manipulated by ion-gating (Adv. sci. 3/2025)}, volume = {12}, year = {2025}, }
• (2025). Develop reusable carbon sub-micrometer composites with record-high Cd(II) removal capacity (Adv. sci. 3/2025). ADVS, 12(3), 2570014. (www)

  @article{ , archive = {J_ADVS}, author = {Mengke Cui and Huiting Jiao and Shijie Yuan and Bin Dong and Zuxin Xu}, doi = {10.1002/advs.202570014}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2570014}, shortjournal = {Adv. Sci.}, title = {Develop reusable carbon sub-micrometer composites with record-high Cd(II) removal capacity (Adv. sci. 3/2025)}, volume = {12}, year = {2025}, }
• (2025). Shedding light on the active species in a cobalt-based covalent organic framework for the electrochemical oxygen evolution reaction. ADVS, 12(3), 2413555. (www)

  @article{ , abstract = {While considerable efforts have been devoted to developing functionalized covalent organic frameworks (COFs) as oxygen evolution electrocatalysts in recent years, studies related to the investigation of the true catalytically active species for the oxygen evolution reaction (OER) remain lacking in the field. In this work, the active species of a cobalt-functionalized COF (TpBpy-Co) is studied as electrochemical OER catalyst through a series of electrochemical measurements and post-electrolysis characterizations. These results suggest that cobalt oxide-based nanoparticles are formed in TpBpy-Co from Co(II) ions coordinated to the COF backbone when exposing TpBpy-Co to alkaline media, and these newly formed nanoparticles serve as the primary active species for oxygen evolution. The study thus emphasizes that caution is warranted when assessing the catalytic activity of COF electrocatalysts, as the pristine COF may act as the pre-catalyst, with the active species forming only under catalyst operating conditions. Specifically, strong coordination between COFs and metal centers under electrochemical operation conditions is crucial to avoid unintended transformation of COF electrocatalysts. This work thus contributes to the rational development of earth-abundant COF OER catalysts for the production of green hydrogen from renewable resources.}, archive = {J_ADVS}, author = {Pouya Hosseini and Andrés Rodríguez-Camargo and Yiqun Jiang and Siyuan Zhang and Christina Scheu and Liang Yao and Bettina V. Lotsch and Kristina Tschulik}, doi = {10.1002/advs.202413555}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2413555}, shortjournal = {Adv. Sci.}, title = {Shedding light on the active species in a cobalt-based covalent organic framework for the electrochemical oxygen evolution reaction}, volume = {12}, year = {2025}, }
• (2025). Microstructured liquid metal-based embedded-type sensor array for curved pressure mapping. ADVS, 12(3), 2413233. (www)

  @article{ , abstract = {Human hands can envelop the surface of an object and recognize its shape through touch. However, existing stretchable haptic sensors exhibit limited flexibility and stability to detect pressure during deformation, while also solely achieving recognition of planar objects. Inspired by the structure of skin tissue, an embedded construction-enabled liquid metal-based e-skin composed of a liquid metal microstructured electrode (LM-ME) array is fabricated for curved pressure mapping. The embedded LM-ME-based sensor elements are fabricated by using femtosecond laser-induced micro/nanostructures and water/hydrogel assisted patterning method, which enables high sensitivity (7.42 kPa −1 in the range of 0–0.1 kPa) and high stability through an interlinked support isolation structure for the sensor units. The sensor array with a high interfacial toughness of 1328 J m −2 can maintain pressure sensation under bending and stretching conditions. Additionally, the embedded construction and laser-induced bumps effectively reduce crosstalk from 58 to 7.8% compared to conventional flexible sensors with shared surfaces. The stretchable and mechanically stable sensor arrays possess shape-adaptability that enables pressure mapping on non-flat surfaces, which has great potential for object recognition in robotic skins and human-computer interaction.}, archive = {J_ADVS}, author = {Haoyu Li and Chengjun Zhang and Hongyu Xu and Qing Yang and Zexiang Luo and Cheng Li and Lin Kai and Yizhao Meng and Jialiang Zhang and Jie Liang and Feng Chen}, doi = {10.1002/advs.202413233}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2413233}, shortjournal = {Adv. Sci.}, title = {Microstructured liquid metal-based embedded-type sensor array for curved pressure mapping}, volume = {12}, year = {2025}, }
• (2025). Synergistic configuration of binary rhodium single atoms in carbon nanofibers for high-performance alkaline water electrolyzer. ADVS, 12(3), 2413176. (www)

  @article{ , abstract = {Electrochemical alkaline water electrolysis offers significant economic advantages; however, these benefits are hindered by the high kinetic energy barrier of the water dissociation step and the sluggish kinetics of the hydrogen evolution reaction (HER) in alkaline media. Herein, the ensemble effect of binary types of Rh single atoms (Rh-N x and Rh-O x ) on TiO 2 -embedded carbon nanofiber (Rh-TiO 2 /CNF) is reported, which serves as potent active sites for high-performance HER in anion exchange membrane water electrolyzer (AEMWE). Density functional theory (DFT) analyses support the experimental observations, highlighting the critical role of binary types of Rh single atoms facilitated by the TiO 2 sites. The Rh-TiO 2 /CNF demonstrates an impressive areal current density of 1 A cm −2 , maintaining extended durability for up to 225 h in a single-cell setup. Furthermore, a 2-cell AEMWE stack utilizing Rh-TiO 2 /CNF is tested under industrial-scale conditions. This research makes a significant contribution to the commercialization of next-generation high-performance and durable AEMWE stacks for clean hydrogen production.}, archive = {J_ADVS}, author = {Natarajan Logeshwaran and Gyuchan Kim and Pandiarajan Thangavel and Sun Seo Jeon and Kaliannan Thiyagarajan and Kampara Roopa Kishore and Hyunjoo Lee and Inseok Seo and Hongseok Yun and Sungho Lee and Byung-Hyun Kim and Young Jun Lee}, doi = {10.1002/advs.202413176}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2413176}, shortjournal = {Adv. Sci.}, title = {Synergistic configuration of binary rhodium single atoms in carbon nanofibers for high-performance alkaline water electrolyzer}, volume = {12}, year = {2025}, }
• (2025). Surface modifications of layered perovskite oxysulfide photocatalyst Y2Ti2O5S2 to enhance visible-light-driven water splitting. ADVS, 12(3), 2412326. (www)

  @article{ , abstract = {Increasing the efficiency of visible-light-driven water splitting systems will require improvements in the charge separation characteristics and redox reaction kinetics associated with narrow-bandgap photocatalysts. Although the traditional approach of loading a single cocatalyst on selective facets provides reaction sites and reduces the reaction overpotential, pronounced surface charge carrier recombination still results in limited efficiency increases. The present study demonstrates a significant improvement in the hydrogen evolution activity of the layered single-crystal photocatalyst Y 2 Ti 2 O 5 S 2 . Increased performance is obtained through sequential loading of Pt cocatalysts using a two-step process followed by photodeposition of Cr 2 O 3 nanolayers. The stepwise deposition of Pt involved an impregnation-reduction pretreatment with subsequent photodeposition and produced numerous hydrogen production sites while promoting electron capture. The Cr 2 O 3 shells formed on Pt nanoparticles further promoted electron transfer from the Pt to the water and inhibited surface carrier recombination. Importantly, it is also possible to construct a Z-scheme overall water splitting system using the optimized Y 2 Ti 2 O 5 S 2 in combination with surface-modified BiVO 4 in the presence of [Fe(CN) 6 ] 3−/4− , yielding a solar-to-hydrogen energy conversion efficiency of 0.19%. This work provides insights into precise surface modifications of narrow-bandgap photocatalysts as a means of improving the solar water splitting process.}, archive = {J_ADVS}, author = {Xizhuang Liang and Junie Jhon M. Vequizo and Lihua Lin and Xiaoping Tao and Qiulian Zhu and Mamiko Nakabayashi and Daling Lu and Hiroaki Yoshida and Akira Yamakata and Takashi Hisatomi and Tsuyoshi Takata and Kazunari Domen}, doi = {10.1002/advs.202412326}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2412326}, shortjournal = {Adv. Sci.}, title = {Surface modifications of layered perovskite oxysulfide photocatalyst Y2Ti2O5S2 to enhance visible-light-driven water splitting}, volume = {12}, year = {2025}, }
• (2025). Unusual thermo-enhanced second harmonic generation in organic configurationally-locked polyene crystals. ADVS, 12(3), 2412218. (www)

  @article{ , abstract = {To modulate nonlinear optical (NLO) effects of crystalline material holds great application potential in the photoelectronic and optical fields. Organic configurationally-locked polyene represents an exciting NLO family with large second harmonic generation (SHG) effects, whereas it is a huge blank to switch and modulate their NLO property through external stimuli. For the first time, here present unusual thermo-enhanced SHG activities are presented in a polyene-based NLO compound, 2-{3-[2-(4-pyrrolidinphenyl)vinyl]-5,5-dimethylcyclohex-2-enylidene}malononitrile ( 1 ), giving a record-high magnitude of SHG enhancement up to ≈170% during its isomorphic phase transition. Theoretical analysis discloses this behavior stems from the reduced degree of torsion in the π -conjugated structures in 1 , as verified by dihedral angles between its pyrrolidine and phenyl planes. As the first study on thermo-enhanced SHG properties of organic crystals, this work affords a new avenue of modulating physical properties to fabricate high-performance photoelectronic and optical devices.}, archive = {J_ADVS}, author = {Yi Liu and Pengfei Zhu and Qingshun Fan and Zihao Zhao and Linjie Wei and Yu Ma and Haojie Xu and Wuqian Guo and Junhua Luo and Zhihua Sun}, doi = {10.1002/advs.202412218}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2412218}, shortjournal = {Adv. Sci.}, title = {Unusual thermo-enhanced second harmonic generation in organic configurationally-locked polyene crystals}, volume = {12}, year = {2025}, }
• (2025). Modulating the interactions of peptide-polyphenol for supramolecular assembly coatings with controllable kinetics and multifunctionalities. ADVS, 12(3), 2412194. (www)

  @article{ , abstract = {Polyphenols and peptides represent two fundamental building blocks in the kingdom of supramolecular assembly (SA) coatings, which have recently attracted considerable interest. Regulating the assembly kinetics of SA coatings is critical to controlling the performance of SA coatings, but this area is still in its infancy, especially in the SA coating of peptide-polyphenol. Herein, a library of oligopeptides with rich diversity, numerous polyphenols, and modulators are explored to reveal their roles in the formation and regulation of SA coating. Citric acid (CA) is an effective regulator of interaction between the polyphenols and peptides to produce peptide-polyphenol coatings, TCP. The electrostatic interaction between tannic acid (TA) and cationic peptide drives the formation of TCP, while the multiple hydrogen bonds between CA and TA and peptide dominate the assembly kinetics. With optimized assembly pH and the mass ratio of TA, CA, and peptide, the thickness of TCP coating deposits onto diverse substrates (glass, silica, titanium, polystyrene) is ≈400 nm with controllable kinetics. The multifunctional TCP coatings are endowed via peptide-coupled functional units, including enhanced cellular adhesion, elevated osteogenic capacity, anti-protein adsorption, and antimicrobial. This work contributes to the understanding of the assembly kinetics and functionalization of peptide-polyphenol coatings.}, archive = {J_ADVS}, author = {Kaiyuan Huo and Wenjie Liu and Zeyu Shou and Hongxiang Wang and Hao Liu and Yang Chen and Xingjie Zan and Qing Wang and Na Li}, doi = {10.1002/advs.202412194}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2412194}, shortjournal = {Adv. Sci.}, title = {Modulating the interactions of peptide-polyphenol for supramolecular assembly coatings with controllable kinetics and multifunctionalities}, volume = {12}, year = {2025}, }
• (2025). Large-area bright emission of plasmon-coupled dark excitons at room temperature. ADVS, 12(3), 2411841. (www)

  @article{ , abstract = {Brightening dark excitons in transition metal dichalcogenide monolayers (MLs) can provide large-area ultrathin devices for applications in quantum information science and optoelectronics. For practical applications of dark excitons, a robust and bright emission over a wide area at room temperature is desirable; however, no reliable approach has been demonstrated thus far. In this study, an efficient approach is presented for brightening dark excitons at room temperature over a large area of a WSe 2 ML via coupling between plasmons and dark excitons. When a WSe 2 ML is placed on gold micropillars (Au MPs), dark excitons are efficiently coupled to strongly localized surface plasmons at the edges of the Au MPs, along with a strong photoluminescence (PL) emission. Room-temperature dark exciton emission is confirmed via energy-, angle-, and time-resolved spectroscopy experiments, as well as confocal PL mapping. This study provides a generalizable method for the practical application of dark exciton.}, archive = {J_ADVS}, author = {Hyun Jeong and Hyeong Chan Suh and Ga Hyun Cho and Huitae Joo and Yeonjeong Koo and Hayoung Ko and Ki Kang Kim and Youngbum Kim and Jeongyong Kim and Kyoung-Duck Park and Mun Seok Jeong}, doi = {10.1002/advs.202411841}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411841}, shortjournal = {Adv. Sci.}, title = {Large-area bright emission of plasmon-coupled dark excitons at room temperature}, volume = {12}, year = {2025}, }
• (2025). Iono–Magnonic reservoir computing with chaotic spin wave interference manipulated by ion-gating. ADVS, 12(3), 2411777. (www)

  @article{ , abstract = {Physical reservoirs are a promising approach for realizing high-performance artificial intelligence devices utilizing physical devices. Although nonlinear interfered spin-wave multi-detection exhibits high nonlinearity and the ability to map in high dimensional feature space, it does not have sufficient performance to process time-series data precisely. Herein, development of an iono–magnonic reservoir by combining such interfered spin wave multi-detection and ion-gating involving protonation-induced redox reaction triggered by the application of voltage is reported. This study is the first to report the manipulation of the propagating spin wave property by ion-gating and the application of the same to physical reservoir computing. The subject iono–magnonic reservoir can generate various reservoir states in a single homogenous medium by utilizing a spin wave property modulated by ion-gating. Utilizing the strong nonlinearity resulting from chaos, the reservoir shows good computational performance in completing the Mackey–Glass chaotic time-series prediction task, and the performance is comparable to that exhibited by simulated neural networks.}, archive = {J_ADVS}, author = {Wataru Namiki and Daiki Nishioka and Yuki Nomura and Takashi Tsuchiya and Kazuo Yamamoto and Kazuya Terabe}, doi = {10.1002/advs.202411777}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411777}, shortjournal = {Adv. Sci.}, title = {Iono–Magnonic reservoir computing with chaotic spin wave interference manipulated by ion-gating}, volume = {12}, year = {2025}, }
• (2025). Enhancing the therapeutic potential of peptide antibiotics using bacteriophage mimicry strategies. ADVS, 12(3), 2411753. (www)

  @article{ , abstract = {The rise of antibiotic resistance, coupled with a dwindling antibiotic pipeline, presents a significant threat to public health. Consequently, there is an urgent need for novel therapeutics targeting antibiotic-resistant pathogens. Nisin, a promising peptide antibiotic, exhibits potent bactericidal activity through a mechanism distinct from that of clinically used antibiotics. However, its cationic nature leads to hemolysis and cytotoxicity, which has limited its clinical application. Here, nanodelivery systems have been developed by mimicking the mechanisms bacteriophages use to deliver their genomes to host bacteria. These systems utilize bacteriophage receptor-binding proteins conjugated to loading modules, enabling efficient targeting of bacterial pathogens. Peptide antibiotics are loaded via dynamic covalent bonds, allowing for infection microenvironment-responsive payload release. These nanodelivery systems demonstrate remarkable specificity against target pathogens and effectively localize to bacteria-infected lungs in vivo. Notably, they significantly reduce the acute toxicity of nisin, rendering it suitable for intravenous administration. Additionally, these bacteriophage-mimicking nanomedicines exhibit excellent therapeutic efficacy in a mouse model of MRSA-induced pneumonia. The facile synthesis, potent antimicrobial performance, and favorable biocompatibility of these nanomedicines highlight their potential as alternative therapeutics for combating antibiotic-resistant pathogens. This study underscores the effectiveness of bacteriophage mimicry as a strategy for transforming peptide antibiotics into viable therapeutics.}, archive = {J_ADVS}, author = {Hongping Wan and Xinyi Zhong and Shinong Yang and Jiarong Deng and Xu Song and Yong Liu and Yuanfeng Li and Zhongqiong Yin and Xinghong Zhao}, doi = {10.1002/advs.202411753}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411753}, shortjournal = {Adv. Sci.}, title = {Enhancing the therapeutic potential of peptide antibiotics using bacteriophage mimicry strategies}, volume = {12}, year = {2025}, }
• (2025). Wedge-like microstructure of Al2O3/i-Ti3C2Tx electrode with “Nano-pumping” effect for boosting ion diffusion and electrochemical defluoridation. ADVS, 12(3), 2411659. (www)

  @article{ , abstract = {Controlled synthesis and regulation of 2D nanomaterials with sufficient active sites are promising in electrochemical fluorine capture, but simultaneously achieving rapid rates and efficient activity of intercalation materials remains challengs. Herein, an integrated strategy of micro-regulation interlayer space and in situ modification of MXenes is proposed to enhance ion storage kinetics. The wedge-like microstructure of aluminum oxide/incomplete-Ti 3 C 2 T x MXene (Al 2 O 3 /i-Ti 3 C 2 T x ) is constructed by incomplete etching MAX and in situ derivation of A-layer element, in which the sub-nanoscale interlayer space is conducive to the small size ions intercalation, and the formation of “nanopump-like” effect boosted the ions diffusion. As evidenced by simulation calculations, Al 2 O 3 nanoparticles not only shorten the migration distance of electrons/hydrated ions in interlayers but also contribute a lower adsorption energy barrier, bringing excellent capture kinetics and stability. Benefiting from the interfacial conversion-intercalation pseudocapacitance, such electrode is endowed with a high defluoridation capacity (69.9 mg g −1 at 1.6V) and an outstanding instantaneous adsorption rate (9.51 mg g −1 min −1 ), and shows satisfactory stability in more than 200 cycles. The physicochemical coupling strategy opens a novel approach to optimizing the interlayer structure and in situ modification interface of MXene, which also provids a universal idea for efficient capture of varisized ions of intercalation materials.}, archive = {J_ADVS}, author = {Junce Wang and Jinfeng Chen and Ningning Liu and Jingjing Lei and Hong-Wen Gao and Fei Yu and Fanghui Pan and Jie Ma}, doi = {10.1002/advs.202411659}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411659}, shortjournal = {Adv. Sci.}, title = {Wedge-like microstructure of Al2O3/i-Ti3C2Tx electrode with “Nano-pumping” effect for boosting ion diffusion and electrochemical defluoridation}, volume = {12}, year = {2025}, }
• (2025). Ruthenium(II) lipid-mimics drive lipid phase separation to arouse autophagy-ferroptosis cascade for photoimmunotherapy. ADVS, 12(3), 2411629. (www)

  @article{ , abstract = {Lipid-mediated phase separation is crucial for the formation of lipophilic spontaneous domain to regulate lipid metabolism and homeostasis, furtherly contributing to multiple cell death pathways. Herein, a series of Ru(II) lipid-mimics based on short chains or midchain lipids are developed. Among them, Ru-LipM with two dodecyl chains significantly induces natural lipid phase separation via hydrocarbon chain-melting phase transitions. Accompanied by the aggregation of Ru-LipM -labeled lipophilic membrane-less compartments, most polyunsaturated lipids are increased and the autophagic flux is retarded with the adaptor protein sequestosome 1 (p62). Upon low-dose irradiation, Ru-LipM further drives ferritinophagy, providing an additional source of labile iron and rendering cells more sensitive to ferroptosis. Meanwhile, the peroxidation of polyunsaturated lipids occurs due to the deactivation of glutathione peroxidase 4 (GPX4) and the overexpression of acyl-CoA synthetase long-chain family member 4 (ACSL4), leading to the immunogenic ferroptosis. Ultimately, both innate and adaptive immunity are invigorated, indicating the tremendous antitumor capability of Ru-LipM in vivo. This study presents an unprecedented discovery of small molecules capable of inducing and monitoring lipid phase separation, thereby eliciting robust immune responses in living cells. It provides a biosimulation strategy for constructing efficient metal-based immune activators.}, archive = {J_ADVS}, author = {Yue Zheng and Wen-Jin Wang and Jing-Xin Chen and Kun Peng and Xiao-Xiao Chen and Qing-Hua Shen and Bing-Bing Liang and Zong-Wan Mao and Cai-Ping Tan}, doi = {10.1002/advs.202411629}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411629}, shortjournal = {Adv. Sci.}, title = {Ruthenium(II) lipid-mimics drive lipid phase separation to arouse autophagy-ferroptosis cascade for photoimmunotherapy}, volume = {12}, year = {2025}, }
• (2025). Turning the surface electronic effect over core-shell CoS2─FexCo1-xS2 nanooctahedra toward electrochemical water splitting in the alkaline medium. ADVS, 12(3), 2411622. (www)

  @article{ , abstract = {The long-term challenge in overall water splitting is the conflict in the pH condition of electrolytes for achieving efficient hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) at the same time, in addition to the typical cost issue in catalysts. It hence raises an intense research interest in seeking cost-efficient non-noble metal electrocatalysts as well as compromising electrolyte conditions for electrocatalytic HER and OER. To tackle the problems, various approaches are demonstrated to engineer the electronic effect on the active sites of catalysts for enhancing the activities. In this work, the core-shell CoS 2 ─Fe x Co 1-x S 2 nanooctahedra is fabricated with a tunable Fe content over the surface and took them as the model catalyst for systematic studies in alkaline OER and HER. By various X-ray spectroscopies as well as electron microscopy, the results showed that the shells of CoS 2 ─Fe x Co 1-x S 2 nanooctahedra formed the {111} surfaces of Fe 0.9 Co 1.0 S 2 and Fe 0.25 Co 0.75 S 2 with and without the promotion by OH − anions during the syntheses. Catalyzed by the CoS 2 , Fe 0.25 Co 0.75 S 2 , and Fe 0.9 Co 1.0 S 2 {111} surfaces, the results of alkaline OER and HER indicated the Fe 0.9 Co 1.0 S 2 the most superior activities by virtue of the optimized Fe─Co electronic effect. From the predictions by density functional theory (DFT) calculations in reaction thermodynamics, the energy barriers in OER and HER both follow the order of Fe 0.9 Co 0.1 S 2 (111) < Fe 0.25 Co 0.75 S 2 (111) < CoS 2 (111). However, FeS 2 (111) is worse than Fe 0.9 Co 0.1 S 2 (111). From the confirmations by in-situ X-ray spectroscopies in reaction kinetics, the Co sites of Fe 0.9 Co 0.1 S 2 (111) on the core-shell nanooctahedra exhibited much higher activities than those of CoS 2 (111) under the applied potentials for OER and HER, which reflected the electronic benefits from the existing Fe neighbors.}, archive = {J_ADVS}, author = {Lian-Ming Lyu and Yu-Chung Chang and Han-Jung Li and Pei-En Wang and Ruei-Hung Juang and Ming-Yen Lu and Cheng-Shiuan Li and Chun-Hong Kuo}, doi = {10.1002/advs.202411622}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411622}, shortjournal = {Adv. Sci.}, title = {Turning the surface electronic effect over core-shell CoS2─FexCo1-xS2 nanooctahedra toward electrochemical water splitting in the alkaline medium}, volume = {12}, year = {2025}, }
• (2025). Mechanical activation of cPLA2 impedes fatty acid β-oxidation in vein grafts. ADVS, 12(3), 2411559. (www)

  @article{ , abstract = {High-magnitude cyclic stretch from arterial blood pressure significantly contributes to the excessive proliferation and migration of vascular smooth muscle cells (VSMCs), leading to neointima formation in vein grafts. However, the molecular mechanisms remain unclear. This study highlights the critical role of cytosolic Phospholipase A2 (cPLA2)/ Yin Yang 1 (YY1)/ carnitine palmitoyltransferase 1b (CPT1B) signaling in coordinating VSMC mechanical activation by inhibiting fatty acid β-oxidation. Metabolomic analysis showed that a 15%–1 Hz arterial cyclic stretch, compared to a 5%–1 Hz venous stretch, increased long-chain fatty acids in VSMCs. cPLA2, identified as a mechanoresponsive molecule, produces excessive arachidonic acid (ArAc) under the 15%–1 Hz stretch, inhibiting CPT1B expression, a key enzyme in fatty acid β-oxidation. ArAc promotes transcription factor YY1 degradation, downregulating CPT1B. Inadequate fatty acid oxidation caused by knockdown of CPT1B or YY1, or etomoxir treatment, increased nuclear membrane tension, orchestrating the activation of cPLA2. Overexpressing CPT1B or inhibiting cPLA2 reduced VSMC proliferation and migration in vein grafts, decreasing neointimal hyperplasia. This study uncovers a novel mechanism in lipid metabolic reprogramming in vein grafts, suggesting a new therapeutic target for vein graft hyperplasia.}, archive = {J_ADVS}, author = {Linwei Fan and Yuanjun Tang and Jian Liu and Yueqi Liu and Yiwei Xu and Jiayu Liu and Han Liu and Wei Pang and Yuxuan Guo and Weijuan Yao and Tao Zhang and Qin Peng and Jing Zhou}, doi = {10.1002/advs.202411559}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411559}, shortjournal = {Adv. Sci.}, title = {Mechanical activation of cPLA2 impedes fatty acid β-oxidation in vein grafts}, volume = {12}, year = {2025}, }
• (2025). Improving fast-charging performance of lithium-ion batteries through Electrode–Electrolyte interfacial engineering. ADVS, 12(3), 2411466. (www)

  @article{ , abstract = {The solid-electrolyte interphase (SEI) is a key element in anode–electrolyte interactions and ultimately contributes to improving the lifespan and fast-charging capability of lithium-ion batteries. The conventional additive vinyl carbonate (VC) generates spatially dense and rigid poly VC species that may not ensure fast Li + transport across the SEI on the anode. Here, a synthetic additive called isosorbide 2,5-dimethanesulfonate (ISDMS) with a polar oxygen-rich motif is reported that can competitively coordinate with Li + ions and allow the entrance of PF 6 – anions into the core solvation structure. The existence of ISDMS and PF 6 − in the core solvation structure along with Li + ions enables the movement of anions toward the anode during the first charge, leading to a significant contribution of ISDMS and LiPF 6 to SEI formation. ISDMS leads to the creation of ionically conductive and electrochemically stable SEI that can elevate the fast-charging performance and increase the lifespan of LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811)/graphite full cells. Additionally, a sulfur-rich cathode–electrolyte interface with a high stability under elevated-temperature and high-voltage conditions is constructed through the sacrificial oxidation of ISDMS, thus concomitantly improving the stability of the electrolyte and the NCM811 cathode in a full cell with a charge voltage cut-off of 4.4 V.}, archive = {J_ADVS}, author = {Seungwon Kim and Sewon Park and Minjee Kim and Yoonhan Cho and Gumin Kang and Sunghyun Ko and Daebong Yoon and Seungbum Hong and Nam-Soon Choi}, doi = {10.1002/advs.202411466}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411466}, shortjournal = {Adv. Sci.}, title = {Improving fast-charging performance of lithium-ion batteries through Electrode–Electrolyte interfacial engineering}, volume = {12}, year = {2025}, }
• (2025). Deciphering design of aggregation-induced emission materials by data interpretation. ADVS, 12(3), 2411345. (www)

  @article{ , abstract = {This work presents a novel methodology for elucidating the characteristics of aggregation-induced emission (AIE) systems through the application of data science techniques. A new set of chemical fingerprints specifically tailored to the photophysics of AIE systems is developed. The fingerprints are readily interpretable and have demonstrated promising efficacy in addressing influences related to the photophysics of organic light-emitting materials, achieving high accuracy and precision in the regression of emission transition energy (mean absolute error ( MAE ) ∼ 0.13 eV ) and the classification of optical features and excited state dynamics mechanisms ( F 1 score ∼ 0.94). Furthermore, a conditional variational autoencoder and integrated gradient analysis are employed to examine the trained neural network model, thereby gaining insights into the relationship between the structural features encapsulated in the fingerprints and the macroscopic photophysical properties. This methodology promotes a more profound and thorough comprehension of the characteristics of AIE and guides the development strategies for AIE systems. It offers a solid and overarching framework for the theoretical analysis involved in the design of AIE-generating compounds and elucidates the optical phenomena associated with these compounds.}, archive = {J_ADVS}, author = {Junyi Gong and Ziwei Deng and Huilin Xie and Zijie Qiu and Zheng Zhao and Ben Zhong Tang}, doi = {10.1002/advs.202411345}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411345}, shortjournal = {Adv. Sci.}, title = {Deciphering design of aggregation-induced emission materials by data interpretation}, volume = {12}, year = {2025}, }
• (2025). Corneal mucin-targeting liposome nanoplatforms enable effective treatment of dry eye diseases by integrated regulation of ferroptosis and inflammation. ADVS, 12(3), 2411172. (www)

  @article{ , abstract = {The incidence of dry eye disease (DED) has been increasing annually worldwide, creating an urgent need for new therapies. Due to the multifactorial mechanism underlying DED, traditional medications focused on decreasing ocular surface inflammation have been unable to address all the harmful factors and fail to achieve a complete clinical cure. Ferroptosis, a new form of programmed cell death characterized by lipid peroxidation, has become a pivotal contributor to dry eye oxidative stress-driven pathology. Therefore, therapeutic targeting of ferroptosis may be an attractive option for dry eye management. Herein, a sialic acid-targeting peptide-modified liposome loaded with Cyclosporine A (CsA), a typical anti-inflammatory drug, and Ferrostatin-1 (Fer-1), a selective ferroptosis inhibitor, is developed termed as CF@SNPs, for combing and sustaining DED treatment. This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, the sialic acid-targeting peptide prolongs ocular surface retention, further enhancing therapeutic efficacy. The CF@SNPs treatment comprehensively alleviates DED symptoms, including improving corneal defects, augmenting goblet cell count, and restoring tear secretion. Specifically, CF@SNPs attenuate dry eye pathology by suppressing p53-SLC7A11-GSH-dependent ferroptosis and TNF-α-associated inflammatory cascades, accompanied by favorable biocompatibility in vivo. These results underscore the promising potential of this superior nano-formulation for DED pharmacotherapy.}, archive = {J_ADVS}, author = {Yin Zhang and Tinglian Zhou and Kai Wang and Chenqi Luo and Dan Chen and Zeen Lv and Haijie Han and Ke Yao}, doi = {10.1002/advs.202411172}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2411172}, shortjournal = {Adv. Sci.}, title = {Corneal mucin-targeting liposome nanoplatforms enable effective treatment of dry eye diseases by integrated regulation of ferroptosis and inflammation}, volume = {12}, year = {2025}, }
• (2025). Rigid-flexible coupling realized by synergistic engineering of the graphitic-amorphous architecture for durable and fast potassium storage. ADVS, 12(3), 2410966. (www)

  @article{ , abstract = {Graphite anodes hold great potential for potassium-ion batteries (PIBs), yet their practical application is hindered by poor cycle performance caused by substantial interlayer expansion. Herein, a partial graphitic carbon (PGC) is elaborately engineered via the catalytic effect of ferric citrate using pitch as a carbon precursor. Systematically varying the catalyst content enables an optimal PGC design integrating a highly graphitized phase providing abundant active sites for K-ion intercalation, balanced with an amorphous carbon region that accommodates volume expansion and facilitates ion diffusion. The optimized PGC12 electrode exhibits a high reversible capacity of 281.9 mAh g −1 , characterized by a prolonged low-potential plateau region, and excellent cycle stability with a capacity retention of 94.8% after 300 cycles. It also realizes an impressive rate capability with a retained capacity of 222.2 mAh g −1 at 1 C. Moreover, the assembled K-ion full-cell delivers an exceptional energy density of 148.2 Wh kg −1 . In-situ XRD and DFT simulations further verify the distinct phase transition mechanisms and reaction dynamics across different carbon configurations. This work elucidates the impact of carbon configurations on K-storage performance and proposes a structural model for efficient K-ion storage, which is instrumental in the rational design and advancement of carbon anodes in PIBs.}, archive = {J_ADVS}, author = {Mingchi Jiang and Ning Sun and Bin Cao and Xuyang Jian and Razium Ali Soomro and Bin Xu}, doi = {10.1002/advs.202410966}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410966}, shortjournal = {Adv. Sci.}, title = {Rigid-flexible coupling realized by synergistic engineering of the graphitic-amorphous architecture for durable and fast potassium storage}, volume = {12}, year = {2025}, }
• (2025). Metamaterial-enabled hybrid receive coil for enhanced magnetic resonance imaging capabilities. ADVS, 12(3), 2410907. (www)

  @article{ , abstract = {Magnetic resonance imaging (MRI) relies on high-performance receive coils to achieve optimal signal-to-noise ratio (SNR), but conventional designs are often bulky and complex. Recent advancements in metamaterial technology have led to the development of metamaterial-inspired receive coils that enhance imaging capabilities and offer design flexibility. However, these configurations typically face challenges related to reduced adaptability and increased physical footprint. This study introduces a hybrid receive coil design that integrates an array of capacitively-loaded ring resonators directly onto the same plane as the coil, preserving its 2D layout without increasing its size. Both the coil and metamaterial are individually non-resonant at the targeted Larmor frequency, but their mutual coupling induces a resonance shift, achieving a frequency match and forming a hybrid structure with enhanced SNR. Experimental validation on a 3.0 T MRI platform shows that this design allows for adjustable trade-offs between peak SNR and penetration depth, making it adaptable for various clinical imaging scenarios.}, archive = {J_ADVS}, author = {Xia Zhu and Ke Wu and Stephan W. Anderson and Xin Zhang}, doi = {10.1002/advs.202410907}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410907}, shortjournal = {Adv. Sci.}, title = {Metamaterial-enabled hybrid receive coil for enhanced magnetic resonance imaging capabilities}, volume = {12}, year = {2025}, }
• (2025). Oxygen-doped 2D In2Se3 nanosheets with extended in-plane lattice strain for highly efficient piezoelectric energy harvesting. ADVS, 12(3), 2410851. (www)

  @article{ , abstract = {With the emergence of electromechanical devices, considerable efforts have been devoted to improving the piezoelectricity of 2D materials. Herein, an anion-doping approach is proposed as an effective way to enhance the piezoelectricity of α-In 2 Se 3 nanosheets, which has a rare asymmetric structure in both the in-plane and out-of-plane directions. As the O 2 plasma treatment gradually substitutes selenium with oxygen, it changes the crystal structure, creating a larger lattice distortion and, thus, an extended dipole moment. Prior to the O 2 treatment, the lattice extension is deliberately maximized in the lateral direction by imposing in situ tensile strain during the exfoliation process for preparing the nanosheets. Combining doping and strain engineering substantially enhances the piezoelectric coefficient and electromechanical energy conversion. As a result, the optimal harvester with a 0.9% in situ strain and 10 min plasma exposure achieves the highest piezoelectric energy harvesting values of ≈13.5 nA and ≈420 µW cm −2 under bending operation, outperforming all previously reported 2D materials. Theoretical estimation of the structural changes and polarization with gradual oxygen substitution supports the observed dependence of the electromechanical performance.}, archive = {J_ADVS}, author = {Ji Yeon Kim and Woohyun Hwang and Seo Yeon Han and Ye Seul Jung and Fengyi Pang and Wenhu Shen and Cheolmin Park and Sang-Woo Kim and Aloysius Soon and Yong Soo Cho}, doi = {10.1002/advs.202410851}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410851}, shortjournal = {Adv. Sci.}, title = {Oxygen-doped 2D In2Se3 nanosheets with extended in-plane lattice strain for highly efficient piezoelectric energy harvesting}, volume = {12}, year = {2025}, }
• (2025). RNA n6-methyladenosine-binding protein YTHDFs redundantly attenuate cancer immunity by downregulating IFN-γ signaling in gastric cancer. ADVS, 12(3), 2410806. (www)

  @article{ , abstract = {Immunotherapy holds potential as a treatment for gastric cancer (GC), though immune checkpoint inhibitor (ICI) resistance remains an obstacle. One resistance mechanism involves defects in interferon-γ (IFN-γ) signaling, in which IFN-γ is linked to improved responsiveness to ICIs. Herein, the roles of RNA N 6 -methyladenosine (m6A) modifications in regulation of IFN-γ signaling and the responsiveness to ICIs are unveiled. The m6A-binding protein YTH N 6 -methyladenosine RNA-binding protein F1 (YTHDF1) is overexpressed in GC tissues, correlating with the suppression of cancer immunity and poorer survival rates. YTHDF1 overexpression impaired the responsiveness to IFN-γ in GC cells, and knockdown studies indicated the redundant effects of YTHDF2 and YTHDF3 with YTHDF1 in IFN-γ responsiveness. RNA immunoprecipitation sequencing revealed YTHDFs directly target interferon regulatory factor 1 (IRF1) mRNA, a master regulator of IFN-γ signaling, leading to reduced RNA stability and consequent downregulation of IFN-γ signaling. Furthermore, in mouse syngeneic tumor models, Ythdf1 depletion in cancer cells resulted in reduced tumor growth and increased tumor-infiltrating lymphocytes, which are attributed to the augmentation of IFN-γ signaling. Collectively, these findings highlight how YTHDFs modulate cancer immunity by influencing IFN-γ signaling through IRF1 regulation, suggesting their viability as therapeutic targets in cancer immunotherapy.}, archive = {J_ADVS}, author = {Dongjun Jang and Chanwoong Hwa and Seoyeon Kim and Jaeik Oh and Seungjae Shin and Soo-Jin Lee and Jiwon Kim and Sang Eun Lee and Yoojin Yang and Dohee Kim and Seoho Lee and Hae Rim Jung and Yumi Oh and Kyunggon Kim and Hye Seung Lee and Joon-Yong An and Sung-Yup Cho}, doi = {10.1002/advs.202410806}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410806}, shortjournal = {Adv. Sci.}, title = {RNA n6-methyladenosine-binding protein YTHDFs redundantly attenuate cancer immunity by downregulating IFN-γ signaling in gastric cancer}, volume = {12}, year = {2025}, }
• (2025). Trap assisted dynamic mechanoluminescence toward self-referencing and visualized strain sensing. ADVS, 12(3), 2410673. (www)

  @article{ , abstract = {Strain sensors utilizing mechanoluminescent (ML) materials have garnered significant attention and application due to their advantages, such as self-powering, non-contact operation, and real-time response. However, ML-based strain sensing techniques typically rely on the establishing of a mathematical relationship between ML intensity and mechanical parameters. The absolute ML intensity is vulnerable to environmental factors, which can result in measurement errors. Herein, an color-resolved visualized dynamic ML and self-referencing strain sensing is investigated in Ca 9 Al(PO 4 ) 7 : Tb 3+ , Mn 2+ . By analyzing the ML performance under various mechanical stimulations and adjustable strain parameters, a relationship between strain and the ML intensity ratio of Tb 3+ /Mn 2+ is aimed to bed established. This will enable the development of a self-referencing and visualized strain sensing technology. Through a comparison of luminescence characteristics under continuous mechanical stimulation (stretching) and continuous X-ray irradiation, it is discovered that the ratiometric dynamic ML is primarily driven by the dynamic filling and continuous release of carriers form traps, which compensates for the ML of Mn 2+ . Leveraging the self-referencing and color-resolved (from green to red) visualized ML characteristics, an application scenario for monitoring human joint movement is developed. This approach offers new insights into the use of dynamic ML materials in strain sensing and human-machine interaction.}, archive = {J_ADVS}, author = {Tianli Wang and Pengfei Zhang and Jianqiang Xiao and Ziyi Guo and Xiongwu Xie and Jiahao Huang and Jiaojiao Zheng and Xuhui Xu and Lei Zhao}, doi = {10.1002/advs.202410673}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410673}, shortjournal = {Adv. Sci.}, title = {Trap assisted dynamic mechanoluminescence toward self-referencing and visualized strain sensing}, volume = {12}, year = {2025}, }
• (2025). Judicious molecular design of 5H‑Dithieno[3,2‑b: 2′,3′‑d]Pyran-based hole-transporting materials for highly efficient and stable perovskite solar cells. ADVS, 12(3), 2410666. (www)

  @article{ , abstract = {The structural modification of hole-transporting materials (HTMs) is an effective strategy for enhancing photovoltaic performance in perovskite solar cells (PSCs). Herein, a series of dithienopyran (DTP)-based HTMs ( Me-H , Ph-H , CF3-H , CF3-mF , and CF3-oF ) is designed and synthesized by substituting different functional groups on the DTP unit and are used fabricating PSCs. In comparison with Me-H having two methyl substituents on the dithienopyrano ring, the Ph-H having two phenyl substituents on the ring exhibits higher PCEs. Notably, the incorporation of trifluoromethyl groups in CF3-H endows the molecule with a larger dipole moment, deeper HOMO energy level, better film morphology, closer molecular stacking, more efficient defect-passivation, enhanced hydrophobicity, and better photovoltaic performance when compared with the Ph-H counterpart. Furthermore, the HTMs of CF3-mF and CF3-oF , which feature fluorine-substituted triphenylamine, demonstrated excellent film-forming properties, more suitable energy levels, enhanced charge mobility, and improved passivation of the buried interface between HTMs and perovskite. As a result, PSCs employing CF3-mF and CF3-oF gave impressive PCEs of 23.41 and 24.13%, respectively. In addition, the large-area (1.00 cm 2 ) PSCs based on CF3-oF achieved a PCE of 22.31%. Moreover, the PSCs devices with CF3 series HTMs exhibited excellent long-term stability under different conditions.}, archive = {J_ADVS}, author = {Kun-Mu Lee and Chia-Hui Lin and Chia-Chi Chang and Ting-Yu Yang and Wei-Hao Chiu and Wei-Chen Chu and Ya-Ho Chang and Sie-Rong Li and Shih-I Lu and Hsiao-Chi Hsieh and Kang-Ling Liau and Chia Hui Hu and Chih-Hung Chen and Yun-Shuo Liu and Wei-Chun Chou and Mandy M. Lee and Shih-Sheng Sun and Yu-Tai Tao and Yan-Duo Lin}, doi = {10.1002/advs.202410666}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410666}, shortjournal = {Adv. Sci.}, title = {Judicious molecular design of 5H‑Dithieno[3,2‑b: 2′,3′‑d]Pyran-based hole-transporting materials for highly efficient and stable perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Sequentially activated smart DNA nanospheres for photoimmunotherapy and immune checkpoint blockade. ADVS, 12(3), 2410632. (www)

  @article{ , abstract = {Due to the inherent immunosuppression and immune evasion of cancer cells, combining photoimmunotherapy with immune checkpoint blockade leverages phototherapy and immune enhancement, overcoming mutual limitations and demonstrating significant anticancer potential. The main challenges include nonspecific accumulation of agents, uncontrolled activation, and drug carrier safety. Smart DNA nanospheres (NS) is developed with targeted delivery and controllable release of photosensitizers and immune agents to achieve effective synergistic therapy and minimize side effects. The multifunctional NS incorporate a targeting module for programming aptamers, a response module for programming i-motif and DNA/RNA hybrid sequences, and a therapeutic module for packaging photosensitizers and PD-L1 siRNA. NS navigate to the tumor site and are sequentially activated by intracellular acid and enzymes to release photosensitizers and programmed death ligand 1 (PD-L1) small interfering RNA (siRNA) a . Besides tumor killing and immune promotion, activated NS downregulate PD-L1 expression, alleviating immune tolerance and evasion, thus enhancing the immune response. These results indicate that NS significantly enhance antitumor immune responses, synergistically improve antitumor efficacy, and reduce systemic toxicity. This study broadens the application of DNA nanomaterials in precision drug delivery and tumor therapy.}, archive = {J_ADVS}, author = {Yu Chen and Yu Guo and Wen Cheng and Jiahao Fan and Jiacheng Li and Jiajia Song and Xiaohai Yang and Kemin Wang and Jin Huang}, doi = {10.1002/advs.202410632}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410632}, shortjournal = {Adv. Sci.}, title = {Sequentially activated smart DNA nanospheres for photoimmunotherapy and immune checkpoint blockade}, volume = {12}, year = {2025}, }
• (2025). Near-isotropic, extreme-stiffness, continuous 3D mechanical metamaterial sequences using implicit neural representation. ADVS, 12(3), 2410428. (www)

  @article{ , abstract = {Mechanical metamaterials represent a distinct category of engineered materials characterized by their tailored density distributions to have unique properties. It is challenging to create continuous density distributions to design a smooth mechanical metamaterial sequence in which each metamaterial possesses stiffness close to the theoretical limit in all directions. This study proposes three near-isotropic, extreme-stiffness, and continuous 3D mechanical metamaterial sequences by combining topology optimization and data-driven design. Through innovative structural design, the sequences achieve over 98% of the Hashin–Shtrikman upper bounds in the most unfavorable direction. This performance spans a relative density range of 0.2–1, surpassing previous designs, which fall short at medium and higher densities. Moreover, the metamaterial sequence is innovatively represented by the implicit neural function; thus, it is resolution-free to exhibit continuously varying densities. Experimental validation demonstrates the manufacturability and high stiffness of the three sequences.}, archive = {J_ADVS}, author = {Yunkai Zhao and Lili Wang and Xiaoya Zhai and Jiacheng Han and Winston Wai Shing Ma and Junhao Ding and Yonggang Gu and Xiao-Ming Fu}, doi = {10.1002/advs.202410428}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410428}, shortjournal = {Adv. Sci.}, title = {Near-isotropic, extreme-stiffness, continuous 3D mechanical metamaterial sequences using implicit neural representation}, volume = {12}, year = {2025}, }
• (2025). Targeting fibrosis: From molecular mechanisms to advanced therapies. ADVS, 12(3), 2410416. (www)

  @article{ , abstract = {As the final stage of disease-related tissue injury and repair, fibrosis is characterized by excessive accumulation of the extracellular matrix. Unrestricted accumulation of stromal cells and matrix during fibrosis impairs the structure and function of organs, ultimately leading to organ failure. The major etiology of fibrosis is an injury caused by genetic heterogeneity, trauma, virus infection, alcohol, mechanical stimuli, and drug. Persistent abnormal activation of “quiescent” fibroblasts that interact with or do not interact with the immune system via complicated signaling cascades, in which parenchymal cells are also triggered, is identified as the main mechanism involved in the initiation and progression of fibrosis. Although the mechanisms of fibrosis are still largely unknown, multiple therapeutic strategies targeting identified molecular mechanisms have greatly attenuated fibrotic lesions in clinical trials. In this review, the organ-specific molecular mechanisms of fibrosis is systematically summarized, including cardiac fibrosis, hepatic fibrosis, renal fibrosis, and pulmonary fibrosis. Some important signaling pathways associated with fibrosis are also introduced. Finally, the current antifibrotic strategies based on therapeutic targets and clinical trials are discussed. A comprehensive interpretation of the current mechanisms and therapeutic strategies targeting fibrosis will provide the fundamental theoretical basis not only for fibrosis but also for the development of antifibrotic therapies.}, archive = {J_ADVS}, author = {Xingpeng Di and Ya Li and Jingwen Wei and Tianyue Li and Banghua Liao}, doi = {10.1002/advs.202410416}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410416}, shortjournal = {Adv. Sci.}, title = {Targeting fibrosis: From molecular mechanisms to advanced therapies}, volume = {12}, year = {2025}, }
• (2025). Advanced piezoelectric materials, devices, and systems for orthopedic medicine. ADVS, 12(3), 2410400. (www)

  @article{ , abstract = {Harnessing the robust electromechanical couplings, piezoelectric materials not only enable efficient bio-energy harvesting, physiological sensing and actuating but also open enormous opportunities for therapeutic treatments through surface polarization directly interacting with electroactive cells, tissues, and organs. Known for its highly oriented and hierarchical structure, collagen in natural bones produces local electrical signals to stimulate osteoblasts and promote bone formation, inspiring the application of piezoelectric materials in orthopedic medicine. Recent studies showed that piezoelectricity can impact microenvironments by regulating molecular sensors including ion channels, cytoskeletal elements, cell adhesion proteins, and other signaling pathways. This review thus focuses on discussing the pioneering applications of piezoelectricity in the diagnosis and treatment of orthopedic diseases, aiming to offer valuable insights for advancing next-generation medical technologies. Beginning with an introduction to the principles of piezoelectricity and various piezoelectric materials, this review paper delves into the mechanisms through which piezoelectric materials accelerated osteogenesis. A comprehensive overview of piezoelectric materials, devices, and systems enhancing bone tissue repair, alleviating inflammation at infection sites, and monitoring bone health is then provided, respectively. Finally, the major challenges faced by applications of piezoelectricity in orthopedic conditions are thoroughly discussed, along with a critical outlook on future development trends.}, archive = {J_ADVS}, author = {Jingkai Zhang and Chang Liu and Jun Li and Tao Yu and Jing Ruan and Fan Yang}, doi = {10.1002/advs.202410400}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410400}, shortjournal = {Adv. Sci.}, title = {Advanced piezoelectric materials, devices, and systems for orthopedic medicine}, volume = {12}, year = {2025}, }
• (2025). Using the transversal admittance to understand organic electrochemical transistors. ADVS, 12(3), 2410393. (www)

  @article{ , abstract = {The transient behavior of organic electrochemical transistors (OECTs) is complex due to mixed ionic-electronic properties that play a central role in bioelectronics and neuromorphic applications. Some works applied impedance spectroscopy in OECTs for understanding transport properties and the frequency-dependent response of devices. The transversal admittance (drain current vs gate voltage) is used for sensing applications. However, a general theory of the transversal admittance, until now, has been incomplete. The derive a model that combines electronic motion along the channel and vertical ion diffusion by insertion from the electrolyte, depending on several features as the chemical capacitance, the diffusion coefficient of ions, and the electronic mobility. Based on transport and charge conservation equations, it is shown that the vertical impedance produces a standard result of diffusion in intercalation systems, while the transversal impedance contains the electronic parameters of hole accumulation and transport along the channel. The spectral shapes of drain and gate currents and the complex admittance spectra are established by reference to equivalent circuit models for the vertical and transversal impedances, that describe well the measurements of a PEDOT:PSS OECT. New insights are provided to the determination of mobility by the ratio between drain and gate currents.}, archive = {J_ADVS}, author = {Juan Bisquert and Scott T. Keene}, doi = {10.1002/advs.202410393}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410393}, shortjournal = {Adv. Sci.}, title = {Using the transversal admittance to understand organic electrochemical transistors}, volume = {12}, year = {2025}, }
• (2025). Highly thermally conductive liquid crystalline epoxy resin vitrimers with reconfigurable, shape-memory, photo-thermal, and closed-loop recycling performance. ADVS, 12(3), 2410362. (www)

  @article{ , abstract = {The low thermal conductivity, poor toughness, and non-reprocessability of thermosetting epoxy resins severely restrict their applications and sustainable development in flexible electronics. Herein, liquid crystalline epoxy (LCE) and dynamic ester and disulfide bonds are introduced into the cured network of bisphenol A epoxy resin (E-51) to construct highly thermally conductive flexible liquid crystalline epoxy resin (LCER) vitrimers. LCER vitrimers demonstrate adjustable mechanical properties by varying the ratio of LCE to E-51, allowing it to transition from soft to strong. Typically, a 75 mol% LCE to 25 mol% E-51 ratio results in an in-plane thermal conductivity ( λ ) of 1.27 W m −1 K −1 , over double that of pure E-51 vitrimer (0.61 W m −1 K −1 ). The tensile strength and toughness increase 2.88 folds to 14.1 MPa and 2.45 folds to 20.1 MJ m −3 , respectively. Besides, liquid crystalline phase transition and dynamic covalent bonds enable triple shape memory and three-dimensional shape reconstruction. After four reprocessing cycles, λ and tensile strength remain at 94% and 72%, respectively. Integrating carbon nanotubes (CNTs) imparts photo-thermal effect and enables “on” and “off” switch under near-infrared light to LCER vitrimer. Furthermore, the CNTs/LCER vitrimer displays light-induced actuation, self-repairing, and self-welding besides the closed-loop recycling and rapid degradation performance.}, archive = {J_ADVS}, author = {Fengyuan Zhang and Junliang Zhang and Kuan Zhang and Xiao Zhong and Mukun He and Hua Qiu and Junwei Gu}, doi = {10.1002/advs.202410362}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410362}, shortjournal = {Adv. Sci.}, title = {Highly thermally conductive liquid crystalline epoxy resin vitrimers with reconfigurable, shape-memory, photo-thermal, and closed-loop recycling performance}, volume = {12}, year = {2025}, }
• (2025). Prenatal silicon dioxide nanoparticles exposure reduces female offspring fertility without affecting males. ADVS, 12(3), 2410353. (www)

  @article{ , abstract = {Silicon dioxide nanoparticles (SiO 2 NPs) are widely utilized in biomedicine due to their controllable size and biocompatibility. While previous studies have demonstrated that prenatal exposure to SiO 2 NPs can traverse the placental barrier and induce neurotoxicity in offspring. However, their reproductive toxicity remains unclear. Here, it is found that prenatal SiO 2 NPs exposure led to subfertility in female offspring, evidenced by decreased ovulation potential, ovarian reserve, and litter size. In contrast, male offspring maintained normal sperm production and fertility. Mechanistic analyses revealed that prenatal SiO 2 NPs exposure disrupted meiotic recombination and increased oocyte apoptosis, resulting in reduced postnatal primordial follicle formation in females. Conversely, meiotic recombination occurring postnatally in male offspring remained unaffected. Notably, treatment with carboxylate (COOH)-functionalized SiO 2 nanoparticles (SiO 2 -COOH NPs) has a minimal impact on fertility in female offspring. Further research, including clinical studies, is needed to confirm these findings in humans. These findings demonstrated gender-specific reproductive toxicity induced by prenatal SiO 2 NPs exposure and highlighted the importance of considering nanoparticle safety in prenatal contexts.}, archive = {J_ADVS}, author = {Min Lei and Zhenye Zhu and Chenlu Wei and Huihui Xie and Ruizhi Guo and Yanqing Zhao and Keer Wang and Mengchen Wang and Wenhui Chen and Xiqiao Xu and Xinxin Zeng and Yining Xu and Wandi Zhang and Yizhe Chu and Yingpu Sun and Qingling Yang}, doi = {10.1002/advs.202410353}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410353}, shortjournal = {Adv. Sci.}, title = {Prenatal silicon dioxide nanoparticles exposure reduces female offspring fertility without affecting males}, volume = {12}, year = {2025}, }
• (2025). Fast near-infrared organic photodetectors with enhanced detectivity by molecular engineering of acceptor materials. ADVS, 12(3), 2410332. (www)

  @article{ , abstract = {Organic photodetectors (OPDs) with a near-infrared (NIR) response beyond 900 nm are intriguing electronics for various applications. It is challenging to develop NIR OPDs with high sensitivity and fast response. Herein, the acceptor materials of OPDs are tuned to extend detection to ≈1100 nm with improved sensitivity. A new fused ring electron acceptor, ICS (2,2'-((2Z,2'Z)-(((4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b:3,4-b']dithiophene-2,6-diyl)bis(4-((2-ethylhexyl)thio)thiophene-5,2-diyl))bis(methaneylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile), is developed with alkylthio thiophene as the bridge, achieving a small bandgap of 1.35 eV while decreasing dark current densities under reverse bias. By further introducing a secondary acceptor of PC 61 BM, the doping compensation, and unfavored hole injection blocking enable further improvement of detectivity. The PTB7-Th (Poly[4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b;4,5-b']dithiophene-2,6-diyl-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]thiophene-)-2-carboxylate-2-6-diyl]): ICS: PC 61 BM OPDs deliver a low dark current density of 1.23 × 10 −9 A cm −2 , a high peak specific detectivity of 1.09 × 10 13 Jones at 950 nm under −0.2 V, and a fast response speed with a −3 dB bandwidth of 720 kHz biased under −2 V. The photoplethysmography system with the PTB7-Th: ICS: PC 61 BM OPD can reliably monitor heartbeats under 980 nm NIR light. This study promises the development of organic NIR OPDs with high detectivity and fast response by tuning active materials.}, archive = {J_ADVS}, author = {Wentao Zhong and Xinyuan Wang and Wei Wang and Zhulu Song and Yirong Tang and Bulin Chen and Tingbin Yang and Yongye Liang}, doi = {10.1002/advs.202410332}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410332}, shortjournal = {Adv. Sci.}, title = {Fast near-infrared organic photodetectors with enhanced detectivity by molecular engineering of acceptor materials}, volume = {12}, year = {2025}, }
• (2025). Photothermal synergistic hydrogen production via a fly-ash-made interfacial vaporific system. ADVS, 12(3), 2410201. (www)

  @article{ , abstract = {Employing UV–vis spectrum for hydrogen generation and vis-IR spectrum to elevate reaction temperatures and induce phase transitions effectively enhances yield and purifies water, demonstrating a judicious strategy for solar energy utilization. This study presents an interfacial photothermal water splitting system that utilizes all-inorganic, economical industrial by-products known as fly ash cenospheres (FAC) for solar-driven hydrogen generation. In this system, the yield reaches 254.8 µmol h −1 cm −1 , representing an 89% augmentation compared to that of the three-phase system. In situ experiments, combined with theoretical calculation, reveal the system's robust light absorption capacity, facilitating rapid gas separation, thus improves the solar-to-hydrogen (STH) efficiency. Furthermore, the system demonstrates strong performance in turbid water and scalability for expansive applications, achieving a hydrogen yield exceeding 50 L h −1 m −2 from various water sources. Facilitating large-scale hydrogen production and water purification, it thereby establishing its potential as a viable solution for sustainable energy generation.}, archive = {J_ADVS}, author = {Yin Xie and Chenyu Xu and Yan Liu and Entao Zhang and Ziying Chen and Xiaopeng Zhan and Guangyu Deng and Yuan Gao and Yanwei Zhang}, doi = {10.1002/advs.202410201}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410201}, shortjournal = {Adv. Sci.}, title = {Photothermal synergistic hydrogen production via a fly-ash-made interfacial vaporific system}, volume = {12}, year = {2025}, }
• (2025). Symmetric dopant-free si solar cells enabled by TiOx nanolayers: An in-depth study on bipolar carrier selectivity. ADVS, 12(3), 2410179. (www)

  @article{ , abstract = {High-efficiency solar cells require two contact structures, engineered for efficient extraction of photogenerated holes and electrons at the respective electrodes. Herein, crystalline Si solar cell featuring hole- and electron-selective passivating contacts composed entirely of a single material, amorphous titanium oxide (TiO x ), without extrinsic doping is demonstrated. The hole/electron selectivity of the TiO x layers (≈5 nm) is tailored by the oxidation process and the choice of Ti precursor in the atomic layer deposition (ALD). Ex situ and in situ X-ray photoelectron spectroscopy measurements elucidate that the hole-selective TiO x induces significant band bending in the Si (Φ≈0.7 eV), generating a p -type inversion layer in the n -Si absorber. The electron-selective TiO x induces a smaller band bending of Φ<0.35 eV. This clarifies that the bipolar carrier selectivity of TiO x is associated with the different amount of negative fixed charges generated during the ALD process, depending on the choice of Ti precursor and oxidant. In addition, the growth of a hydrogen-containing SiO y nanolayer (≈1-1.5 nm) at the Si/TiO x interface during postdeposition oxidation is crucial for providing chemical passivation in both types of TiO x . These findings pave the way for a deeper understanding of the charge generation mechanism and chemistry at the Si/metal oxide interfaces.}, archive = {J_ADVS}, author = {Takuya Matsui and Shohei Fukaya and Shona McNab and James McQueen and Kazuhiro Gotoh and Hitoshi Sai and Noritaka Usami and Ruy Sebastian Bonilla}, doi = {10.1002/advs.202410179}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410179}, shortjournal = {Adv. Sci.}, title = {Symmetric dopant-free si solar cells enabled by TiOx nanolayers: An in-depth study on bipolar carrier selectivity}, volume = {12}, year = {2025}, }
• (2025). Accurate spatial heterogeneity dissection and gene regulation interpretation for spatial transcriptomics using dual graph contrastive learning. ADVS, 12(3), 2410081. (www)

  @article{ , abstract = {Recent advances in spatial transcriptomics have enabled simultaneous preservation of high-throughput gene expression profiles and the spatial context, enabling high-resolution exploration of distinct regional characterization in tissue. To effectively understand the underlying biological mechanisms within tissue microenvironments, there is a requisite for methods that can accurately capture external spatial heterogeneity and interpret internal gene regulation from spatial transcriptomics data. However, current methods for region identification often lack the simultaneous characterizing of spatial structure and gene regulation, thereby limiting the ability of spatial dissection and gene interpretation. Here, stDCL is developed, a dual graph contrastive learning method to identify spatial domains and interpret gene regulation in spatial transcriptomics data. stDCL adaptively incorporates gene expression data and spatial information via a graph embedding autoencoder, thereby preserving critical information within the latent embedding representations. In addition, dual graph contrastive learning is proposed to train the model, ensuring that the latent embedding representation closely resembles the actual spatial distribution and exhibits cluster similarity. Benchmarking stDCL against other state-of-the-art clustering methods using complex cortex datasets demonstrates its superior accuracy and effectiveness in identifying spatial domains. Our analysis of the imputation matrices generated by stDCL reveals its capability to reconstruct spatial hierarchical structures and refine differential expression assessment. Furthermore, it is demonstrated that the versatility of stDCL in interpretability of gene regulation, spatial heterogeneity at high resolution, and embryonic developmental patterns. In addition, it is also showed that stDCL can successfully annotate disease-associated astrocyte subtypes in Alzheimer's disease and unravel multiple relevant pathways and regulatory mechanisms.}, archive = {J_ADVS}, author = {Zhuohan Yu and Yuning Yang and Xingjian Chen and Ka-Chun Wong and Zhaolei Zhang and Yuming Zhao and Xiangtao Li}, doi = {10.1002/advs.202410081}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2410081}, shortjournal = {Adv. Sci.}, title = {Accurate spatial heterogeneity dissection and gene regulation interpretation for spatial transcriptomics using dual graph contrastive learning}, volume = {12}, year = {2025}, }
• (2025). Integrating prior knowledge using transformer for gene regulatory network inference. ADVS, 12(3), 2409990. (www)

  @article{ , abstract = {Gene regulatory network (GRN) inference, a process of reconstructing gene regulatory rules from experimental data, has the potential to discover new regulatory rules. However, existing methods often struggle to generalize across diverse cell types and account for unseen regulators. Here, this work presents GRNPT, a novel Transformer-based framework that integrates large language model (LLM) embeddings from publicly accessible biological data and a temporal convolutional network (TCN) autoencoder to capture regulatory patterns from single-cell RNA sequencing (scRNA-seq) trajectories. GRNPT significantly outperforms both supervised and unsupervised methods in inferring GRNs, particularly when training data is limited. Notably, GRNPT exhibits exceptional generalizability, accurately predicting regulatory relationships in previously unseen cell types and even regulators. By combining LLMs ability to distillate biological knowledge from text and deep learning methodologies capturing complex patterns in gene expression data, GRNPT overcomes the limitations of traditional GRN inference methods and enables more accurate and comprehensive understanding of gene regulatory dynamics.}, archive = {J_ADVS}, author = {Guangzheng Weng and Patrick Martin and Hyobin Kim and Kyoung Jae Won}, doi = {10.1002/advs.202409990}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409990}, shortjournal = {Adv. Sci.}, title = {Integrating prior knowledge using transformer for gene regulatory network inference}, volume = {12}, year = {2025}, }
• (2025). Emodin enhanced microwave-responsive heterojunction with powerful bactericidal capacity and immunoregulation for curing bacteria-infected osteomyelitis. ADVS, 12(3), 2409979. (www)

  @article{ , abstract = {Eradication of osteomyelitis caused by bacterial infections is still a major challenge. Microwave therapy has the inherent advantage of deep penetration in curing deep tissue infections. However, the antibacterial efficiency of sensitizers is limited by the weak energy of microwaves. Here, a hybrid heterojunction system (Fe 3 O 4 /CuS/Emo) is designed for curing bacterially infected osteomyelitis. As an enhanced microwave sensitizer, it shows supernormal microwave response ability. Specifically, Fe 3 O 4 acts as a matrix to mediate magnetic loss. After CuS loading, the heterogeneous interface forms induce significant interfacial polarization, which increasing dielectric loss. On the basis of the heterojunction formed by the two semiconductors, emodin is innovatively introduced to modify it. This integration not only accelerates the movement of charge carriers but also enhances polarization loss due to the numerous functional groups present on the surface. This further optimizes the microwave thermal and catalytic response. In addition, the unique anti-inflammatory properties of emodin confer the ability of hybrid heterojunction to regulate the immune microenvironment. In vivo studies reveal that heterojunction modified by emodin programmed elimination of bacteria and regulation of the immune microenvironment. It offers a revolutionary approach to the treatment of bacterial osteomyelitis.}, archive = {J_ADVS}, author = {Tao Xu and Hao Cheng and Hailiang Pei and Jiameng Wang and Yiwei Shi and Xiangyu Zhang and Di Huang}, doi = {10.1002/advs.202409979}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409979}, shortjournal = {Adv. Sci.}, title = {Emodin enhanced microwave-responsive heterojunction with powerful bactericidal capacity and immunoregulation for curing bacteria-infected osteomyelitis}, volume = {12}, year = {2025}, }
• (2025). Cupric doping hollow prussian blue nanoplatform for enhanced cholesterol depletion: A promising strategy for breast cancer therapy and metastasis inhibition. ADVS, 12(3), 2409967. (www)

  @article{ , abstract = {The dysregulated cholesterol metabolism in breast cancer cells drives malignancy, invasion, and metastasis, emphasizing the significance of reducing abnormal cholesterol accumulation for effective cancer treatment and metastasis inhibition. Despite its promise, cholesterol oxidase (ChOx) encounters challenge due to limited catalytic efficiency and susceptibility to harsh conditions. To overcome these hurdles, biocompatible nanoplatforms (Cu-HPB/C) tailored for efficient cholesterol depletion are introduced. Cu 2+ -doped hollow Prussian blue (Cu-HPB) acts as a carrier, shelter, and enhancer for ChOx, bolstering tumor-targeting ability, stability, and enzymatic activity. Tumor-responsive released Cu 2+ notably augments ChOx activity, facilitating cholesterol depletion and disrupting lipid rafts, thereby impeding cell invasion and migration. Additionally, H 2 O 2 generated from the oxidase reaction enhances Cu-HPB's chemo dynamic therapeutic efficacy. Transcriptomic analysis validates Cu-HPB/C's impact on cholesterol homeostasis and reveals cell death mechanisms including oxidative stress, ferroptosis, cuproptosis, and apoptosis. Demonstrating therapeutic efficacy in both 4T1 tumor subcutaneous and metastasis mouse models, the study presents a direct and effective strategy for tumor therapy and metastasis inhibition through enhanced cholesterol depletion.}, archive = {J_ADVS}, author = {Shuangqian Yan and Panpan Xue and Ying Sun and Tingjie Bai and Sijie Shao and Xuemei Zeng}, doi = {10.1002/advs.202409967}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409967}, shortjournal = {Adv. Sci.}, title = {Cupric doping hollow prussian blue nanoplatform for enhanced cholesterol depletion: A promising strategy for breast cancer therapy and metastasis inhibition}, volume = {12}, year = {2025}, }
• (2025). Engineering magnetic heterostructures with synergistic regulation of charge-transfer and spin-ordering for enhanced water oxidation. ADVS, 12(3), 2409842. (www)

  @article{ , abstract = {The design of heterojunctions offers a crucial solution for energy conversion and storage challenges, but current research predominantly focuses on charge transfer benefits, often neglecting spin attribute regulation despite the increasing recognition of spin-sensitivity in many chemical reactions. In this study, a novel magnetic heterostructure, CoFe 2 O 4 @CoFeMo 3 O 8 , is designed to simultaneously modulate charge and spin characteristics, and systematically elucidated their synergistic impact on the oxygen evolution reaction (OER). Experimental results and density functional theory calculations confirmed that the magnetic heterostructure exhibits both charge transfer and spin polarization. It is found that the charge-transfer behavior enhances conductivity and adsorption ability through band structure regulation. Meanwhile, magnetically polarized electrons promote triplet O 2 generation and accelerate electron transport via spin-selective pathways. Moreover, the heterostructure's effective response to external alternating magnetic fields further amplifies the spin-dependent effect and introduces a magnetothermal effect, locally heating the active sites through spin flip, thereby boosting catalytic activity. Consequently, the OER activity of the magnetic heterostructure is improved by 83.8 times at 1.5 V compared to its individual components. This magnetic heterojunction strategy presents a promising avenue for advanced catalysis through synergistic regulating of charge-transfer and spin-ordering.}, archive = {J_ADVS}, author = {Chongyan Hao and Yang Wu and Xiaobo Zheng and Yumeng Du and Yameng Fan and Weikong Pang and Anton Tadich and Shujun Zhang and Thomas Frauenheim and Tianyi Ma and Xiaoning Li and Zhenxiang Cheng}, doi = {10.1002/advs.202409842}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409842}, shortjournal = {Adv. Sci.}, title = {Engineering magnetic heterostructures with synergistic regulation of charge-transfer and spin-ordering for enhanced water oxidation}, volume = {12}, year = {2025}, }
• (2025). Tubular MYDGF slows progression of chronic kidney disease by maintaining mitochondrial homeostasis. ADVS, 12(3), 2409756. (www)

  @article{ , abstract = {Mitochondrial dysfunction is a key event driving the maladaptive repair of tubular epithelial cells during the transition from acute kidney injury to chronic kidney disease (CKD). Therefore, identifying potential targets involved in mitochondrial dysfunction in tubular epithelial cells is clinically important. Myeloid-derived growth factor (MYDGF), a novel secreted protein, plays important roles in multiple cardiovascular diseases, but the function of MYDGF in tubular epithelial cells remains unknown. In the present study, it is found that MYDGF expression is significantly reduced in the cortex of the kidney, especially in the proximal tubules, from mice with CKD. Notably, lower expression of MYDGF is observed in tubules from patients with CKD and the level of MYDGF correlated with key factors related to kidney fibrosis and estimated glomerular filtration rate (eGFR) in patients with CKD. Tubule-specific deletion of Mydgf exacerbates kidney injury in mice with CKD; however, Mydgf overexpression attenuates kidney fibrosis by remodeling mitochondrial homeostasis in tubular epithelial cells. Mechanistically, renal tubular MYDGF positively regulates the expression of isocitrate dehydrogenase 2 (IDH2), restores mitochondrial homeostasis, and slows CKD progression. Thus, this study indicates that MYDGF derived from tubules may be an effective therapeutic strategy for patients with CKD.}, archive = {J_ADVS}, author = {Xiaohan Liu and Yang Zhang and Youzhao Wang and Yujie Yang and Zhe Qiao and Ping Zhan and Huiying Jin and Qianqian Xu and Wei Tang and Yu Sun and Yan Zhang and Fan Yi and Min Liu}, doi = {10.1002/advs.202409756}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409756}, shortjournal = {Adv. Sci.}, title = {Tubular MYDGF slows progression of chronic kidney disease by maintaining mitochondrial homeostasis}, volume = {12}, year = {2025}, }
• (2025). Nematic and smectic phases with proper ferroelectric order. ADVS, 12(3), 2409754. (www)

  @article{ , abstract = {A material showing a sequence of three ferroelectric liquid crystalline phases below the paraelectric nematic phase is synthesized and studied. The polar order of molecules appearing due to the dipole–dipole interactions in the ferroelectric nematic, N F , phase is preserved also in the smectic phases: orthogonal SmA F and tilted SmC F . The ferroelectric ground state of both smectic phases is confirmed by their second harmonic generation (SHG) activity and polarization switching. In the SmC F phase the polarization becomes oriented to the electric field by decreasing the tilt angle to zero. Although both smectic phases are ferroelectric in nature, their dielectric response is found to be very different.}, archive = {J_ADVS}, author = {Grant J. Strachan and Ewa Górecka and Jadwiga Szydłowska and Anna Makal and Damian Pociecha}, doi = {10.1002/advs.202409754}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409754}, shortjournal = {Adv. Sci.}, title = {Nematic and smectic phases with proper ferroelectric order}, volume = {12}, year = {2025}, }
• (2025). Implantable multifunctional micro-oxygen reservoir system for promoting vascular-osteogenesis via remodeling regenerative microenvironment. ADVS, 12(3), 2409636. (www)

  @article{ , abstract = {Hypoxia and reactive oxygen species (ROS) overaccumulation cause persistent oxidative stress and impair intrinsic regenerative potential upon tissue injury. For local tissue injury with hypoxia, such as bone fracture and defects, a localized-sufficient oxygen supply is highly desirable but remains challenging. Therefore, to explore a strategy and its intrinsic mechanism for supplying oxygen locally and remodeling the regenerative microenvironment, an innovative oxygenating hydrogel microsphere system with sustained oxygenation and antioxidant properties is introduced by loading CaO 2 @SiO 2 @PDA (CSP) nanoparticles. Specifically, the CSP nanoparticles exhibited broad-spectrum free radicals scavenging ability, along with prolonged controlled-release of oxygen once integrated into the gelatin methacrylate anhydride (GelMA) microspheres (CSP-GM). The CSP-GM with extra cellular matrix (ECM)-mimicking structures reconstructed living niches, promoting the adhesion and proliferation of bone marrow stromal cells (BMSCs). As a multifaceted microenvironment regulator, CSP-GM remodeled the regenerative microenvironment by synergistically producing oxygen and scavenging ROS, recovering mitochondrial homeostasis and antioxidant defenses of BMSCs, promoting angiogenesis and osteogenesis under hypoxia conditions via precisely modulating the Nrf2/HO-1 signaling pathway. The multiple pro-regenerative effects of the implantable functionalized micro-oxygen reservoir on bone repair are further corroborated by the enhanced vascularized bone formation in rat femoral defects, presenting a comprehensive and promising strategy for tissue repair.}, archive = {J_ADVS}, author = {Min Rui and Jiannan Mao and Hongshuai Wu and Yujian Hui and Hao Shen and Yilin Yang and Tao Ma and Kewei Ren and Juan Wang and Wenguo Cui and Qin Shi and Huilin Yang}, doi = {10.1002/advs.202409636}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409636}, shortjournal = {Adv. Sci.}, title = {Implantable multifunctional micro-oxygen reservoir system for promoting vascular-osteogenesis via remodeling regenerative microenvironment}, volume = {12}, year = {2025}, }
• (2025). End-to-end pierced carbon nanosheets with meso-holes. ADVS, 12(3), 2409546. (www)

  @article{ , abstract = {The remarkable properties of 2D nanomaterials are well known. However, their high interfacial adhesion energy often leads to restacking issues, limiting their potential in various applications. A strategic synthetic approach is presented to overcome this challenge. Specifically, the study first demonstrates the use of layered aluminosilicate as a sacrificial 2D template to allow the growth of highly ordered meso-holey polymeric layers, which can be subsequently exfoliated upon the removal of aluminosilicate and thermally converted to perpendicularly open meso-holey carbon (POMC). On the other hand, perpendicularly blocked meso-holey carbon (PBMC) is obtained with non-sacrificial 2D template of graphene oxide. When both POMC and PBMC are evaluated by operando hydrodynamic electrochemical impedance spectroscopy and transmission line model analysis for electrochemical reduction of oxygen, POMC achieves a remarkable improvement of charge transfer and mass transfer by up to 4.1 and 7.9 times, respectively, as compared to PBMC. This study therefore highlights the importance of perpendicularly open 2D nanoarchitectures in circumventing the restacking effect, offering valuable insights for leveraging 2D nanomaterials with open meso-holes in various applications.}, archive = {J_ADVS}, author = {Minjun Kim and Hiroki Nara and Yusuke Asakura and Takashi Hamada and Peng Yan and Jacob Earnshaw and Meng An and Miharu Eguchi and Yusuke Yamauchi}, doi = {10.1002/advs.202409546}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409546}, shortjournal = {Adv. Sci.}, title = {End-to-end pierced carbon nanosheets with meso-holes}, volume = {12}, year = {2025}, }
• (2025). Multi-mechanism collaborative bionic fixation technique between a wide range of solid interfaces. ADVS, 12(3), 2409507. (www)

  @article{ , abstract = {For rough surfaces, stable, fast, and repeatable fixation has wide applicability in transportation, fire protection, and other fields. Different rough surfaces present technical challenges for achieving convenient and reliable fixation. Based on the highly adhesive attachment structures of typical organisms, a multi-mechanism (negative pressure adsorption, mechanical locking, and chemical bonding) cooperative bionic fixation device is proposed. The device is equipped with a suction disc with gradient guide channels, a microneedles friction-enhancing unit, and fast-curable UV glue. These components work together to complete the fixation. The detachment work (max. 5.7 and 5.5 J) and pull-off force (max. 377 and 175 N) are evaluated on sandpaper of different roughness under vertical and horizontal pulling respectively. By analyzing the detachment process and experimental curves, the cooperative principle of the multi-mechanism is identified. In addition, the microneedles with soft backing at the bionic fixation device bottom improve its adaptability to rough surfaces. The gradient guide channels of the suction disc create Laplace pressure to speed up the UV glue flow and shorten fixation time. Furthermore, its applicability is demonstrated by combining it with monitoring equipment and an adult to attach to rough surfaces.}, archive = {J_ADVS}, author = {Shixun Fu and Jun Sun and Zhiyong Hu and Yongjin Zhao and Tianchang Yao and Xipeng Wang and Yuanming Ji and Kai Deng and Keju Ji}, doi = {10.1002/advs.202409507}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409507}, shortjournal = {Adv. Sci.}, title = {Multi-mechanism collaborative bionic fixation technique between a wide range of solid interfaces}, volume = {12}, year = {2025}, }
• (2025). Cyclic evolution of synergized spin and orbital angular momenta. ADVS, 12(3), 2409377. (www)

  @article{ , abstract = {Spin angular momentum (SAM) and orbital angular momentum (OAM) are fundamental physical characteristics described by polarization and spatial degrees of freedom, respectively. Polarization is a feature of vector fields while spatial phase gradient determines the OAM ubiquitous to any scalar field. Common wisdom treats these two degrees of freedom as independent principles to manipulate wave propagations. Here, their synergy is demonstrated. This is achieved by introducing two orthogonal p -orbitals as eigenbases, whose spatial modal features are exploited to generate OAM, and the associated orbital orientations provide means to simultaneously manipulate polarizations. Through periodic modulation and directional coupling, a full cyclic evolution of synchronized and synergized SAM-OAM is realized. Remarkably, this evolution acquires a nontrivial geometric phase, leading to its representation on a Möbius strip. Experimentally, an acoustic cavity array is designed, whose dipole resonances precisely mimic the p -orbitals, with pressure fields featuring the spatial characteristics and velocity fields the vectorial orientations. Based on this synergy, a spin-orbital-Hall effect is further showcased, highlighting the intricate locking of handedness, directionality, spin density, and spatial mode profile. This study unveils a fundamental connection between SAM and OAM, promising avenues for their novel applications in trapping, coding, and communications.}, archive = {J_ADVS}, author = {Lei Liu and Xiao-Chen Sun and Yuan Tian and Xiujuan Zhang and Ming-Hui Lu and Yan-Feng Chen}, doi = {10.1002/advs.202409377}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409377}, shortjournal = {Adv. Sci.}, title = {Cyclic evolution of synergized spin and orbital angular momenta}, volume = {12}, year = {2025}, }
• (2025). Calcium channel blocker lacidipine promotes antitumor immunity by reprogramming tryptophan metabolism. ADVS, 12(3), 2409310. (www)

  @article{ , abstract = {Dysfunction of calcium channels is involved in the development and progression of some cancers. However, it remains unclear the role of calcium channel inhibitors in tumor immunomodulation. Here, calcium channel blocker lacidipine is identified to potently inhibit the enzymatic activity and expression of indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism. Lacidipine activates effector T cells and incapacitates regulatory T cells (Tregs) to augment the anti-tumor effect of chemotherapeutic agents in breast cancer by converting immunologically “cold” into “hot” tumors. Mechanistically, lacidipine targets calcium channels (Ca V 1.2/1.3) to inhibit Pyk2-JAK1-calmodulin complex-mediated IDO1 transcription suppression, which suppresses the kynurenine pathway and maintains the total nicotinamide adenine dinucleotide (NAD) pool by regulating NAD biosynthesis. These results reveal a new function of calcium channels in IDO1-mediated tryptophan metabolism in tumor immunity and warrant further development of lacidipine for the metabolic immunotherapy in breast cancer.}, archive = {J_ADVS}, author = {Yuwen Sheng and Chong Qiao and Zhonghui Zhang and Xiaoke Shi and Linhan Yang and Ruiying Xi and Jialing Yu and Wanli Liu and Guolin Zhang and Fei Wang}, doi = {10.1002/advs.202409310}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409310}, shortjournal = {Adv. Sci.}, title = {Calcium channel blocker lacidipine promotes antitumor immunity by reprogramming tryptophan metabolism}, volume = {12}, year = {2025}, }
• (2025). A multifunctional cobalt-containing implant for treating biofilm infections and promoting osteointegration in infected bone defects through macrophage-mediated immunomodulation. ADVS, 12(3), 2409200. (www)

  @article{ , abstract = {Treating bone infections and ensuring bone recovery is one of the major global problems facing modern orthopedics. Prolonged antibiotic use may increase the risk of antimicrobial resistance, and inflammation caused by biofilms can obstruct tissue healing, making bone infection treatment even more challenging. The optimal treatment strategy combines immune response modification to promote osteogenesis with effective bacterial infection removal that does not require long-term antibiotic use. A one-step plasma immersion ion implantation approach is used to create titanium alloy implants incorporating cobalt. According to experimental findings, cobalt-containing titanium implants exhibit improved antibacterial activity by efficiently disrupting biofilm formations and reducing Methicillin-resistant Staphylococcus aureus adherence by over 80%. Additionally, the implants exhibit superior anti-inflammatory and osseointegration properties. RNA sequencing analysis reveals the potential mechanism of Co 2+ in regulating the polarization of macrophages toward the anti-inflammatory M2 phenotype, which is crucial for creating an immune environment conducive to bone healing. Concurrently, these implants promote osteogenic differentiation while suppressing osteoclast activity, further supporting bone repair. Overall, without exogenous recombinant proteins or antibiotics, the implants effectively eradicate infections and expedite bone repair, offering a novel therapeutic strategy for complex skeletal diseases with clinical promise.}, archive = {J_ADVS}, author = {Nongyang Yan and Hao Zhou and Penghe Jin and Tengfei Li and Qi Liu and Hao Ning and Zhixin Ma and Linfei Feng and Tao Jin and Youwen Deng and Zhengwei Wu}, doi = {10.1002/advs.202409200}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409200}, shortjournal = {Adv. Sci.}, title = {A multifunctional cobalt-containing implant for treating biofilm infections and promoting osteointegration in infected bone defects through macrophage-mediated immunomodulation}, volume = {12}, year = {2025}, }
• (2025). Slow Metabolism–Driven amplification of hepatic PPARγ agonism mediates benzbromarone-induced obesity-specific liver injury. ADVS, 12(3), 2409126. (www)

  @article{ , abstract = {Obesity and nonalcoholic fatty liver disease (NAFLD) are established risk factors for drug-induced liver injury (DILI). The previous study demonstrates that benzbromarone (BBR), a commonly prescribed pharmaceutical agent for managing gout and hyperuricemia, exacerbates hepatic steatosis and liver injury specifically in obese individuals. However, the precise mechanism underpinning this adverse effect remains incompletely elucidated. Given the significance of BBR and its analogs in anti-gout/hyperuricemia drug discovery, elucidating the mechanism by which BBR exacerbates obesity-specific DILI warrants further investigation. In this study, through a combined multi-omics, pharmacological, and pharmacokinetic approaches, it is found that BBR-induced obesity-specific DILI is primarily through the potentiation of peroxisome proliferator-activated receptor gamma (PPARγ) signaling pathways. Further in vivo and in vitro pharmacokinetic analyses reveal that obese db/db mice exhibited a diminished capacity to metabolize BBR in their livers. This reduction leads to prolonged retention of BBR, subsequently resulting in chronic and sustained hepatic PPARγ agonism. This study demonstrates that a slow metabolism-driven amplification of hepatic PPARγ agonism mediates BBR-induced obesity-specific hepatic steatosis and subsequent DILI, which also emphasizes the importance of the reduced hepatic drug metabolism capacity in patients with obesity or pre-existing NAFLD in both clinical practice and drug discovery processes.}, archive = {J_ADVS}, author = {Guanting Li and Yourong Hu and Han Zhao and Ziyu Peng and Xin Shang and Jia Zhang and Kunxin Xie and Meiwei Li and Xiaohang Zhou and Qinyao Zhou and Kai Li and Fang Zhou and Heyao Wang and Zhijian Xu and Jiali Liu and Peng Sun}, doi = {10.1002/advs.202409126}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409126}, shortjournal = {Adv. Sci.}, title = {Slow Metabolism–Driven amplification of hepatic PPARγ agonism mediates benzbromarone-induced obesity-specific liver injury}, volume = {12}, year = {2025}, }
• (2025). Possible superconductivity transition in nitrogen-doped lutetium hydride observed at megabar pressure. ADVS, 12(3), 2409092. (www)

  @article{ , abstract = {The pursuit of room-temperature superconductivity at an accessible synthetic pressure has been a long-held dream for both theoretical and experimental physicists. Recently, a controversial report by Dasenbrock-Gammon et al. claims that the nitrogen-doped lutetium trihydride exhibits room-temperature superconductivity at near-ambient pressure. However, many researchers have failed to independently reproduce these results, which has sparked intense skepticism on this report. In this work, a LuH 2±x N y sample is fabricated using high-pressure and high-temperature methods. The composition and structural characterization are the same as the aforementioned near-ambient superconductor. In situ X-ray diffraction investigations indicate that a high-pressure phase transition toward Fm m -LuH 3±x N y occurred in the sample at 59 GPa. The temperature-dependent resistance measurements reveal that two possible superconductivity transition are observed at 95 GPa, with T c1 ≈6.5 K for high- T c phase and T c2 ≈2.1 K for low- T c phase, arising from the disparate phases in the sample. Resistivity measurements in the Fm m -LuH 3±x N y phase under varying magnetic fields exhibited characteristics consistent with superconductivity, with an upper critical field μ 0 H c2 (0) of 3.3 T measured at 163 GPa. This work is expected to shed some light on the controversy surrounding superconductivity in the nitrogen-doped lutetium hydride system.}, archive = {J_ADVS}, author = {Xingbin Zhao and Yu Huang and Shuailing Ma and Hao Song and Yanwei Cao and Hao Jiang and Yanping Huang and Tian Cui}, doi = {10.1002/advs.202409092}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409092}, shortjournal = {Adv. Sci.}, title = {Possible superconductivity transition in nitrogen-doped lutetium hydride observed at megabar pressure}, volume = {12}, year = {2025}, }
• (2025). 3D printed multi-cavity soft actuator with integrated motion and sensing functionalities via bio-inspired interweaving foldable endomysium. ADVS, 12(3), 2409060. (www)

  @article{ , abstract = {The human muscle bundle generates versatile movements with synchronous neurosensory, enabling human to undertake complex tasks, which inspires researches into functional integration of motions and sensing in actuators for robots. Although soft actuators have developed diverse motion capabilities utilizing the inherent compliance, the simultaneous-sensing approaches typically involve adding sensing components or embedding certain-signal-field substrates, resulting in structural complexity and discrepant deformations between the actuation parts with high-dimensional motions and the sensing parts with heterogeneous stiffnesses. Inspired by the muscle-bundle multifiber mechanism, a multicavity functional integration (McFI) approach is proposed for soft pneumatic actuators to simultaneously realize multidimensional motions and sensing by separating and coordinating active and passive cavities. A bio-inspired interweaving foldable endomysium (BIFE) is introduced to construct and reinforce the multicavity chamber with optimized purposive foldability, enabling 3D printing single-material fabrication. Performing elongation, contraction, and bidirectional bending, the McFI actuator senses its spatial position, orientation, and axial force, based on the kinematic and sensing models built on multi-cavity pressures. Two McFI-actuator-driven robots are built: a soft crawling robot with path reconstruction and a narrow-maneuverable soft gripper with object exteroception, validating the practicality in stand-alone use of the actuator and the potential for intelligent soft robotic innovation of the McFI approach.}, archive = {J_ADVS}, author = {Zhonggui Fang and Shaowu Tang and Yinyin Su and Xiaohuang Liu and Sicong Liu and Juan Yi and Zheng Wang and Jian S. Dai}, doi = {10.1002/advs.202409060}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409060}, shortjournal = {Adv. Sci.}, title = {3D printed multi-cavity soft actuator with integrated motion and sensing functionalities via bio-inspired interweaving foldable endomysium}, volume = {12}, year = {2025}, }
• (2025). Boosted efficiency of Fe2O3 for photocatalytic CO2 reduction via engineering Fe−O−Ti bonding. ADVS, 12(3), 2409002. (www)

  @article{ , abstract = {Visible light-driven photocatalytic CO 2 reduction (CO 2 RR) offers a sustainable and promising solution to environmental and energy challenges. However, the design of efficient photocatalysts is hindered by poor interface interactions in heterojunctions and a limited understanding of reaction kinetics. A modified Fe 2 O 3 photocatalyst, M-Fe 2 O 3 @MXene, is introduced featuring KH-550-modified M-Fe 2 O 3 hollow nanocubes coated with MXene, constructed via an electrostatic and Fe−O−Ti bonding self-assembly method. This design achieves an unprecedented CO production rate of 240 µmol g⁻¹ h⁻¹ among non-noble metal catalysts (8.6 folds vs Fe 2 O 3 ). The Fe−O−Ti sites enhance *COOH intermediate formation and CO production through higher electron deficiency of Fe 3+ and rapid charge transfer. This study offers new insights on the use of functional metal oxides and high-quality Mxene layers to design efficient metal oxide-based photocatalysts.}, archive = {J_ADVS}, author = {Jingyi Wu and Wei Wang and Xudan Chen and Qiquan Luo and Changzeng Yan and Zhen Jiao and Yuehui Li}, doi = {10.1002/advs.202409002}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2409002}, shortjournal = {Adv. Sci.}, title = {Boosted efficiency of Fe2O3 for photocatalytic CO2 reduction via engineering Fe−O−Ti bonding}, volume = {12}, year = {2025}, }
• (2025). Cytoskeletal vimentin directs cell-cell transmission of hepatitis c virus. ADVS, 12(3), 2408917. (www)

  @article{ , abstract = {Hepatitis C virus (HCV) is a major human pathogen causing liver diseases. Although direct-acting antiviral agents effectively inhibit HCV infection, cell–cell transmission remains a critical venue for HCV persistence in vivo. However, the underlying mechanism of how HCV spreads intercellularly remains elusive. Here, we demonstrated that vimentin, a host intermediate filaments protein, is dispensable for HCV infection in cell models but essential for simulated in vivo infection in differentiated hepatocytes. Genetic removal of vimentin markedly and specifically disrupts HCV cell–cell transmission without influencing cell-free infection. Through mutual co-immunoprecipitation screening, we identified that the N-terminal 1–95 amino acids of vimentin exclusively interact with the HCV envelope protein E1. Introducing either full-length or head region of vimentin is capable of restoring the cell–cell transmission deficiency in vimentin-knockout cells. Moreover, we showed that it is vimentin on the plasma membrane of recipient cells that orchestrates HCV cell–cell transmission. Consequently, vimentin antibody, either applied individually or in combination with HCV neutralizing antibody, exerts pronounced inhibition of HCV cell–cell transmission. Together, the results unveil an unrecognized function of vimentin as a unique venue dominating viral transmission, providing novel insights into propelling advancements in vimentin-targeted anti-HCV therapies.}, archive = {J_ADVS}, author = {Yifan Xing and Zeyu Wen and Jie Mei and Xinyi Huang and Shuangshuang Zhao and Jin Zhong and Yaming Jiu}, doi = {10.1002/advs.202408917}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408917}, shortjournal = {Adv. Sci.}, title = {Cytoskeletal vimentin directs cell-cell transmission of hepatitis c virus}, volume = {12}, year = {2025}, }
• (2025). Polymeric multivalent fc binding peptides-fabricated clinical compounding bispecific antibody potentiates dual immunotherapy targeting PD1 and CTLA-4. ADVS, 12(3), 2408899. (www)

  @article{ , abstract = {Dual Opdivo plus Yervoy immunotherapy, targeting the immune checkpoints PD1 and CTLA-4, is successful in clinical use. However, it is associated with a high incidence of adverse events, and its therapeutic efficacy needs improving. In this study, polymeric multivalent Fc-binding peptides (PLG-Fc-III-4C) are employed to fabricate a bispecific antibody (PD1/CTLA-4 BsAb) to potentiate dual immunotherapy targeting PD1 and CTLA-4. The PD1/CTLA-4 BsAb is prepared by mixing PLG-Fc-III-4C with aPD1 and aCTLA-4 in an aqueous solution for 3 h using the clinically optimal 3:1 proportion of aPD1 to aCTLA-4. PD1/CTLA-4 BsAb significantly inhibits tumors in MC38 colon cancer-bearing mice more effectively than the combination of aPD1 and aCTLA-4, with tumor suppression rates of 96.8% and 77.3%, respectively. It also induces a higher percentage of CD8 + T cells and increases the secretion of effector cytokines while reducing Treg levels in tumors compared to phosphate-buffered saline, indicating significant tumor immunity regulation. Mechanistically, a 6.3-fold increase in PD1/CTLA-4 BsAb accumulation in tumors due to the tumor targeting ability of aPD1, and the PD1/CTLA-4 BsAb significantly reduces the adverse colitis event in healthy mice, compared to aPD1 and aCTLA-4. Thus, these findings provide a novel approach to enhance antitumor therapy using aPD1 and aCTLA-4.}, archive = {J_ADVS}, author = {Zongyu Liu and Hongyu Chu and Weidong Zhao and Chenguang Yang and Tongjun Liu and Na Shen and Zhaohui Tang}, doi = {10.1002/advs.202408899}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408899}, shortjournal = {Adv. Sci.}, title = {Polymeric multivalent fc binding peptides-fabricated clinical compounding bispecific antibody potentiates dual immunotherapy targeting PD1 and CTLA-4}, volume = {12}, year = {2025}, }
• (2025). ZFP36 regulates vascular smooth muscle contraction and maintains blood pressure. ADVS, 12(3), 2408811. (www)

  @article{ , abstract = {Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. Zinc finger protein 36 (ZFP36) is an RNA-binding protein that regulates mRNA stability by binding to adenylate-uridylate-rich elements in the mRNA 3′-untranslated region. This study reveals that ZFP36 expression is highly elevated in the arteries of hypertensive patients and rodents. In cultured vascular smooth muscle cell (VSMC), angiotensin II (AngII) activates poly (ADP-ribose) polymerases1 (PARP1) to stimulate Zfp36 expression at the transcriptional level. VSMC-specific ZFP36 deletion reduces vessel contractility and blood pressure levels in mice. Mechanistically, ZFP36 regulates G protein-coupled receptors (GPCRs)-mediated increases in intracellular calcium levels through impairing the mRNA stability of regulator of G protein signaling 2 (RGS2). Moreover, the VSMC-specific ZFP36 deficiency attenuates AngII-induced hypertension and vascular remodeling in mice. AAV-mediated ZFP36 knockdown ameliorates spontaneous hypertension in rats. These findings elucidate that ZFP36 plays an important role in the regulation of smooth muscle contraction and blood pressure through modulating RGS2 expression. ZFP36 inhibition may represent a new therapeutic strategy for the treatment of hypertension.}, archive = {J_ADVS}, author = {Xiuru Cui and Yawei Wang and Hanlin Lu and Lei Wang and Xianwei Xie and Shenghao Zhang and Pavel Kovarik and Shuijie Li and Shanshan Liu and Qunye Zhang and Jianmin Yang and Cheng Zhang and Jinwei Tian and Yan Liu and Wencheng Zhang}, doi = {10.1002/advs.202408811}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408811}, shortjournal = {Adv. Sci.}, title = {ZFP36 regulates vascular smooth muscle contraction and maintains blood pressure}, volume = {12}, year = {2025}, }
• (2025). Flux synthesis of A-site disordered perovskite La0.5M0.5TiO3 (M═Li, na, k) nanorods tailored for solid composite electrolytes. ADVS, 12(3), 2408805. (www)

  @article{ , abstract = {Inorganic fillers play an important role in improving the ionic conductivity of solid composite electrolytes (SCEs) for Li-ion batteries. Among inorganic fillers, perovskite-type lithium lanthanum titanate (LLTO) stands out for its high bulk Li + conductivity on the order of 10 −3 S cm −1 at room temperature. According to a literature survey, the optimal LLTO filler should possess the following characteristics: i) a single-crystal structure to minimize grain boundaries; ii) a small particle size to increase the filler/polymer interface area; iii) a 1D morphology for efficient interface channels; and iv) cubic symmetry to facilitate rapid bulk Li + diffusion within the filler. However, the synthesis of single crystal, 1D LLTO nanomaterials with cubic symmetry is challenging. Herein, a flux strategy is developed to synthesize La 0.5 M 0.5 TiO 3 (LMTO, M═Li, Na, and K) single-crystal nanorods with an A-site-disordered, cubic perovskite phase. The flux media promotes the oriented growth of nanorods, prevents nanorods from sintering, and provides multiple alkali metal ion doping at M sites to stabilize the cubic phase. SCEs compositing the Li + -conducting LMTO nanorods as fillers and poly[vinylene carbonate- co -lithium sulfonyl(trifluoromethane sulfonyl)imide methacrylate] matrix exhibit more than twice the conductivity of the neat polymer electrolyte (30.6 vs 14.0 µS cm −1 at 303 K).}, archive = {J_ADVS}, author = {Tao Wang and Jiyoung Ock and X. Chelsea Chen and Fan Wang and Meijia Li and Matthew S. Chambers and Gabriel M. Veith and Lauren B. Shepard and Susan B. Sinnott and Albina Borisevich and Miaofang Chi and Amit Bhattacharya and Raphaële J. Clément and Alexei P Sokolov and Sheng Dai}, doi = {10.1002/advs.202408805}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408805}, shortjournal = {Adv. Sci.}, title = {Flux synthesis of A-site disordered perovskite La0.5M0.5TiO3 (M═Li, na, k) nanorods tailored for solid composite electrolytes}, volume = {12}, year = {2025}, }
• (2025). Isolation transformer based very low frequency antenna with enhanced radiation characteristics. ADVS, 12(3), 2408770. (www)

  @article{ , abstract = {Very low frequency electromagnetic waves adeptly propagate in harsh cross-medium environments, surmounting the rapid attenuation that impedes high-frequency counterparts. Traditional low frequency antennas, however, encounter challenges concerning size, efficiency, and power. Here, an isolation transformer based very low frequency loop antenna with compact size and well impedance matching is proposed to enhance radiation characteristics for long-distance communication. By utilizing the high magnetic permeability amorphous/nanocrystalline alloy Fe 73.5 Cu 1 Nb 3 B 9 Si 13.5 , the isolation transformer enables efficient and stable high-current input. This design surpasses the current limitation of the conventional loop antennas, thereby improving its electromagnetic performance. Consequently, the radiation intensity of proposed antenna can be effectively increased over 30 times compared to traditional loop antennas. According to the experimental measurements, the transmission distance is over 340 m at 15 kHz using a single proposed antenna with a diameter of 2 m. Its robust performance, such as high radiation efficiency, low power consumption, and long-distance transmission capacity, suggests significant potential for applications in underground communications and underwater information transmission.}, archive = {J_ADVS}, author = {Jingqi Wu and Zilun Zeng and Liwei Wang and Jianchun Xu and Ke Bi}, doi = {10.1002/advs.202408770}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408770}, shortjournal = {Adv. Sci.}, title = {Isolation transformer based very low frequency antenna with enhanced radiation characteristics}, volume = {12}, year = {2025}, }
• (2025). Lipid nanoparticles with fine-tuned composition show enhanced colon targeting as a platform for mRNA therapeutics. ADVS, 12(3), 2408744. (www)

  @article{ , abstract = {Lipid Nanoparticles (LNPs) recently emerged as an invaluable RNA delivery platform. With many LNP-based therapeutics in the pre-clinical and clinical pipelines, there is extensive research dedicated to improving LNPs. These efforts focus mainly on the tolerability and transfectability of new ionizable lipids and RNAs, or modulating LNPs biodistribution with active targeting strategies. However, most formulations follow the well-established lipid proportions used in clinically approved products. Nevertheless, investigating the effects of LNPs composition on their biodistribution can expand the toolbox for particle design, leading to improved delivery strategies. Herein, a new LNPs (30-n-LNPs) formulation with increasing amounts of phospholipids is investigated as a possible mRNA delivery system for treating Inflammatory Bowel Diseases. Compared to LNPs with benchmark composition (b-LNPs), n-LNPs containing 30% distearoylphosphatidylcholine (DSPC) are well tolerated following intravenous administration and display natural targeting toward the inflamed colon in dextran sodium sulfate (DSS)-colitis bearing mice, while de-targeting clearing organs such as the liver and spleen. Using interleukin-10-encoding mRNA as therapeutic cargo, n-LNPs demonstrated a reduction of pathological burden in colitis-bearing mice. n-LNPs represent a starting point to further investigate the influence of LNPs composition on systemic biodistribution, ultimately opening new therapeutic modalities in different pathologies.}, archive = {J_ADVS}, author = {Riccardo Rampado and Gonna Somu Naidu and Olga Karpov and Meir Goldsmith and Preeti Sharma and Assaf Ezra and Lior Stotsky and Dor Breier and Dan Peer}, doi = {10.1002/advs.202408744}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408744}, shortjournal = {Adv. Sci.}, title = {Lipid nanoparticles with fine-tuned composition show enhanced colon targeting as a platform for mRNA therapeutics}, volume = {12}, year = {2025}, }
• (2025). Triboelectric-inertial sensing glove enhanced by charge-retained strategy for human-machine interaction. ADVS, 12(3), 2408689. (www)

  @article{ , abstract = {As technology advances, human-machine interaction (HMI) demands more intuitive and natural methods. To meet this demand, smart gloves, capable of capturing intricate hand movements, are emerging as vital HMI tools. Moreover, triboelectric-based sensors, with their self-powered, cost-effective, and material various characteristics, can offer promising solutions for enhancing existing glove systems. However, a key limitation of these sensors is that charge leakage in the measurement circuit results in capturing only transient signals, rather than continuous changes. To address this issue, a charge-retained circuit that effectively prevents triboelectric signal attenuation is developed, enabling accurate measurement of continuous finger movements. This innovation forms the foundation of a highly integrated smart glove system, enhancing HMI functionality by combining continuous triboelectric signals with inertial sensor data. The system showcases a diverse range of applications, including complex robotic control, virtual reality interaction, smart home lighting adjustments, and intuitive interface operations. Furthermore, by leveraging artificial intelligence (AI) techniques, the system achieves accurate recognition of complex sign language with an impressive 99.38% accuracy. This work presents a charge-retained approach for continuous sensing with triboelectric-based sensors, offering valuable insights for developing future multifunctional HMI and sign language recognition systems. The proposed smart glove system, with its dual-mode sensing and AI integration, holds great potential for revolutionizing various domains and enhancing user experiences.}, archive = {J_ADVS}, author = {Bo Yang and Jia Cheng and Xuecheng Qu and Yuning Song and Lifa Yang and Junyao Shen and Ziqian Bai and Linhong Ji}, doi = {10.1002/advs.202408689}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408689}, shortjournal = {Adv. Sci.}, title = {Triboelectric-inertial sensing glove enhanced by charge-retained strategy for human-machine interaction}, volume = {12}, year = {2025}, }
• (2025). Exercise-activated mPFC tri-synaptic pathway ameliorates depression-like behaviors in mouse. ADVS, 12(3), 2408618. (www)

  @article{ , abstract = {Exercise is considered as playing a pivotal role in the modulation of emotional responses. However, a precise circuit that mediates the effects of exercise on depression have yet to be elucidated. Here, a molecularly defined tri-synaptic pathway circuit is identified that correlates motor inputs with antidepressant effects. With this pathway, initial inputs from neurons within the dorsal root ganglia (DRG) project to excitatory neurons in the gracile nucleus (GR), which in turn connect with 5-HTergic neurons in the dorsal raphe nucleus (DRN), eventually coursing to excitatory pyramidal neurons within the medial prefrontal cortex (mPFC). Exercise activates this pathway, with the result that depressive- and anxiety-like behaviors in mice are significantly reduced. In addition, it is found that exercise may exert antidepressant effects through regulating synaptic plasticity within this tri-synaptic pathway. These findings reveal a hindbrain-to-forebrain neuronal circuit that specifically modulates depression and provides a potential mechanism for the antidepressant effects of exercise.}, archive = {J_ADVS}, author = {Tian Lan and Ye Li and Xiao Chen and Wenjing Wang and Changmin Wang and Haiyan Lou and Shihong Chen and Shuyan Yu}, doi = {10.1002/advs.202408618}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408618}, shortjournal = {Adv. Sci.}, title = {Exercise-activated mPFC tri-synaptic pathway ameliorates depression-like behaviors in mouse}, volume = {12}, year = {2025}, }
• (2025). Direct-print 3D electrodes for large-scale, high-density, and customizable neural interfaces. ADVS, 12(3), 2408602. (www)

  @article{ , abstract = {Silicon-based microelectronics can scalably record and modulate neural activity at high spatiotemporal resolution, but their planar form factor poses challenges in targeting 3D neural structures. A method for fabricating tissue-penetrating 3D microelectrodes directly onto planar microelectronics using high-resolution 3D printing via 2-photon polymerization and scalable microfabrication technologies are presented. This approach enables customizable electrode shape, height, and positioning for precise targeting of neuron populations distributed in 3D. The effectiveness of this approach is demonstrated in tackling the critical challenge of interfacing with the retina—specifically, selectively targeting retinal ganglion cell (RGC) somas while avoiding the axon bundle layer. 6,600-microelectrode, 35 µm pitch, tissue-penetrating arrays are fabricated to obtain high-fidelity, high-resolution, and large-scale retinal recording that reveals little axonal interference, a capability previously undemonstrated. Confocal microscopy further confirms the precise placement of the microelectrodes. This technology can be a versatile solution for interfacing silicon microelectronics with neural structures at a large scale and cellular resolution.}, archive = {J_ADVS}, author = {Pingyu Wang and Eric G. Wu and Hasan Uluşan and Eric Tianjiao Zhao and A.J. Phillips and Alexandra Kling and Madeline Rose Hays and Praful Krishna Vasireddy and Sasidhar Madugula and Ramandeep Vilkhu and Andreas Hierlemann and Guosong Hong and E.J. Chichilnisky and Nicholas A. Melosh}, doi = {10.1002/advs.202408602}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408602}, shortjournal = {Adv. Sci.}, title = {Direct-print 3D electrodes for large-scale, high-density, and customizable neural interfaces}, volume = {12}, year = {2025}, }
• (2025). A purely biomanufactured system for delivering nanoparticles and STING agonists. ADVS, 12(3), 2408539. (www)

  @article{ , abstract = {Nanovaccines have significantly contributed in the prevention and treatment of diseases. However, most of these technologies rely on chemical or hybrid semibiological synthesis methods, which limit the manufacturing performance advantages and improved inoculation outcomes compared with traditional vaccines. Herein, a universal and purely biological nanovaccine system is reported. This system integrates three modules: (1) self-assembling nanoparticles, (2) self-catalyzed synthesis of small-molecule stimulator of interferon gene (STING) agonists, and (3) delivery vectors that target the cytosolic surveillance system. Various nanoparticles are efficiently self-assembled using this system. After confirming the excellent immunostimulatory and lymph node targeting of this system, its broad-spectrum antiviral efficacy is further demonstrated. By leveraging the comprehensive biosynthetic capabilities of bacterial cells, this system can efficiently combine various adjuvant-active modular components and antigenic cargo, thereby providing a highly diversified and potent vaccine platform.}, archive = {J_ADVS}, author = {Yu-an Li and Yi Feng and Wenjing Li and Yuqin Zhang and Yanni Sun and Shifeng Wang and Roy Curtiss and Huoying Shi}, doi = {10.1002/advs.202408539}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408539}, shortjournal = {Adv. Sci.}, title = {A purely biomanufactured system for delivering nanoparticles and STING agonists}, volume = {12}, year = {2025}, }
• (2025). Smart driving hardware augmentation by flexible piezoresistive sensor matrices with grafted-on anticreep composites. ADVS, 12(3), 2408313. (www)

  @article{ , abstract = {Signal drift and hysteresis of flexible piezoresistive sensors pose significant challenges against the widespread applications in emerging fields such as electronic skin, wearable equipment for metaverse and human-AI (artificial intelligence) interfaces. To address the creep and relaxation issues associated with pressure-sensitive materials, a highly stable piezoresistive composite is proposed, using polyamide-imide (PAI) fibers as the matrix and in situ grafted-polymerized polyaniline (PANI) as the semi-conducting layer. The PAI with large rigid fluorenylidene groups exhibits a high glass transition temperature of 372 °C (PAI 5-5), which results in an extremely long relaxation time at room temperature and consequently offers outstanding anti-creep/relaxation performances. The enhancement of PAI-PANI interfacial bonding through in situ grafting improves the sensor reliably. The sensor presents high linear sensitivity of 35.3 kPa −1 over a pressure range of 0.2–20 kPa, outstanding repeatability, and excellent dynamic stability with only a 3.8% signal deviation through ≈10 000 cycles. Real-time visualization of pressure distribution is realized by sensor matrices, which demonstrate the capability of tactile gesture recognition on both flat and curved surfaces. The recognition of sitting postures is achieved by two 12 × 12 matrices facilitated by machine learning, which prompts the potential for the augmentation of smart driving.}, archive = {J_ADVS}, author = {Kaifeng Chen and Hua Yang and Ang Wang and Linsen Tang and Xin Zha and Ndeutala Selma Iita and Hong Zhang and Zhuoxuan Li and Xinyu Wang and Wei Yang and Shaoxing Qu and Zongrong Wang}, doi = {10.1002/advs.202408313}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408313}, shortjournal = {Adv. Sci.}, title = {Smart driving hardware augmentation by flexible piezoresistive sensor matrices with grafted-on anticreep composites}, volume = {12}, year = {2025}, }
• (2025). Develop reusable carbon sub-micrometer composites with record-high Cd(II) removal capacity. ADVS, 12(3), 2408295. (www)

  @article{ , abstract = {Cd(II)-induced pollution across diverse water bodies severely threatens ecosystems and human health. Nevertheless, achieving ultra-efficient and cost-effective treatment of trace amounts of heavy metals remains a major challenge. Herein, the novel carbon sub-micrometer composites (CSMCs) supported Fe 0 @γ-Fe 2 O 3 core-shell clusters nanostructures are designed and synthesized through a series of universally applicable methods. Research data on adsorption behavior clearly revealed that resorcinol/formaldehyde 1.25-basic ferric acetate (RF-1.25BFA) and RF-1.25BFA-540 have surprising adsorption capacities. Employing the adsorbent dosage of 0.025 g L −1 , the adsorption capacities for 10 mg L −1 Cd(II) reached 400.00 mg g −1 with ultrafast adsorption kinetics, alongside theoretical maximum adsorption capacities for Cd(II) of 1108.87 and 1065.06 mg g −1 using 0.025 g L −1 adsorbent, respectively, setting a new record-high level. Additionally, they demonstrated exceptional stability and reusability, maintaining Cd(II) removal efficiency above 95% even after 15 adsorption–desorption cycles. Importantly, this study is the first to unveil a new ultrafast successive two-step enrichment–hydrolysis adsorption mechanism for Cd(II) removal, emphasizing the critical role played by iron clusters nanostructures in constructing a high-alkalinity adsorption microenvironment on the surface of the materials. The findings reported pioneered a new avenue for the rational design of high-performance environmental remediation materials, aiming to overcome the limitations of traditional mine drainage treatment.}, archive = {J_ADVS}, author = {Mengke Cui and Huiting Jiao and Shijie Yuan and Bin Dong and Zuxin Xu}, doi = {10.1002/advs.202408295}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408295}, shortjournal = {Adv. Sci.}, title = {Develop reusable carbon sub-micrometer composites with record-high Cd(II) removal capacity}, volume = {12}, year = {2025}, }
• (2025). Negative pressure smart patch to sense and heal the wound. ADVS, 12(3), 2408077. (www)

  @article{ , abstract = {Negative pressure wound therapy (NPWT) offers significant advantages in terms of rate and time for healing through generating sub-vacuum to draw out inflammatory exudate and promote wound closure. However, continuous drainage probably leads to healing delay due to the lack of information about the real status of the wound bed and the potential risk of infection. To address this concern, printed Negative Pressure Smart Patch (NPSP) is reported by integrating smart real-time sensing acidity (infection) and glucose, and anti-infection into NPWT systems. In addition, NPSP delivers vancomycin through chitosan porous microspheres under negative pressure to modulate wound healing. Compared with NPWT, NPSP projects a promising approach to removing bacteria, reducing local inflammation, and accelerating healing in a short period of time.}, archive = {J_ADVS}, author = {Xing Liu and Peng Zhao and Xiaozhuo Wu and Yawei Zhao and Feifan Zhou and Ying Luo and Xiaoli Jia and Wen Zhong and Malcolm Xing and Guozhong Lyu}, doi = {10.1002/advs.202408077}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408077}, shortjournal = {Adv. Sci.}, title = {Negative pressure smart patch to sense and heal the wound}, volume = {12}, year = {2025}, }
• (2025). A building-integrated hybrid photovoltaic-thermal (PV-t) window for synergistic light management, electricity and heat generation. ADVS, 12(3), 2408057. (www)

  @article{ , abstract = {The installation of common solar panels and collectors in the built environment requires access to significant roof space, which is limited. This motivates the development of high-efficiency, building-integrated technologies that can maximize space utilization and energy provision. In this work, a building-integrated hybrid photovoltaic-thermal window (PVTW) is fabricated and tested, composed of a semi-transparent photovoltaic (PV) layer and a selectively absorptive liquid-based thermal absorber. It is demonstrated that, at 30° inclination, the PVTW can simultaneously generate electricity, with an electrical efficiency of 3.6%, and provide ≈50 °C water, with a thermal efficiency of 10.7%, in the middle of a typical summer day (20th July) in London (maximum ambient temperature ≈34 °C, solar irradiance ≈1100 W m −2 at midday). The water temperature decreases by ≈7 °C, whilst thermal efficiency improves to 17.6% as the inclination angle increases to 90° (vertical); the electrical efficiency reduces marginally (3.3%). Compared to a liquid-based solar-thermal window (STW), the PVTW can generate hot water at ≈10 °C higher temperature and with 10% absolute increase in thermal efficiency when the inclination angle is 60°, plus electricity. The wider uptake of this technology in glass-based urban spaces has the potential to generate significant energy while reducing building temperature management costs.}, archive = {J_ADVS}, author = {Francesco Polito and Gan Huang and Christos N. Markides}, doi = {10.1002/advs.202408057}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2408057}, shortjournal = {Adv. Sci.}, title = {A building-integrated hybrid photovoltaic-thermal (PV-t) window for synergistic light management, electricity and heat generation}, volume = {12}, year = {2025}, }
• (2025). Self-healing COCu-tac hydrogel enhances iNSCs transplantation for spinal cord injury by promoting mitophagy via the FKBP52/AKT pathway. ADVS, 12(3), 2407757. (www)

  @article{ , abstract = {In the realm of neural regeneration post-spinal cord injury, hydrogel scaffolds carrying induced neural stem cells (iNSCs) have demonstrated significant potential. However, challenges such as graft rejection and dysfunction caused by mitochondrial damage persist after transplantation, presenting formidable barriers. Tacrolimus, known for its dual role as an immunosuppressant and promoter of neural regeneration, holds the potential for enhancing iNSC transplantation. However, systemic administration of tacrolimus often comes with severe side effects. This study pioneers the development of a self-healing hydrogel with sustained-release tacrolimus (COCu-Tac), tailored specifically for iNSC transplantation after spinal cord injury. This research reveals that the sustained release of tacrolimus enhances axonal growth and improves mitochondrial quality control in iNSCs and neurons. Further analysis shows that tacrolimus targets FKBP52 rather than FKBP51, enhancing mitophagy via the FKBP52/AKT pathway. This advanced system demonstrates significant efficacy in promoting neural regeneration and restoring motor function following spinal cord injury.}, archive = {J_ADVS}, author = {Zhenming Tian and Han-Jian Hu and Chun Cheung Chan and Tian Hu and Chaoyang Cai and Hong Li and Limin Rong and Gang-Biao Jiang and Bin Liu}, doi = {10.1002/advs.202407757}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2407757}, shortjournal = {Adv. Sci.}, title = {Self-healing COCu-tac hydrogel enhances iNSCs transplantation for spinal cord injury by promoting mitophagy via the FKBP52/AKT pathway}, volume = {12}, year = {2025}, }
• (2025). Intelligent pyroptosis inducer for precise and augmented tumor therapy through specific activation pyroptosis in tumor. ADVS, 12(3), 2407713. (www)

  @article{ , abstract = {Pyroptosis inducer, a powerful anti-tumor agent that causes obvious programmed cell death and immune stimulation, has been challenged to trigger specific pyroptotic tumor cell death while keeping pyroptosis silence in normal cells. Here, an intelligent inducer is reported that acts as a reactive oxygen species (ROS) scavenger in normal cells to keep pyroptosis silence, while serving as ROS generator to induce obvious pyroptotic tumor cells death dependent on high hydrogen peroxide levels and near-infrared laser irradiation. This switchable activity ensures this inducer to precisely kill the tumor cells with augmented immunogenicity while causing minimal damage to normal cells. Moreover, the catalase-like activity endows this inducer to overcome limitation of tumor hypoxia on ROS generation and show significant pyroptosis activation, further initiating the immune response to inhibit the tumor metastases in vivo. This study provides valuable insights into design new pyroptosis inducer with controllable pyroptosis activity to specifically induce programmed tumor cell pyroptosis for precise and augmented tumor therapy with minimal side effects.}, archive = {J_ADVS}, author = {Linlin Huo and Shiqi Zhu and Muyao Li and Mingya Tan and Mengke Fan and Jiayi Zhao and Jie Zeng and Meiling Liu and Kunyan Liu and Chao Tong and Zhenghuan Zhao}, doi = {10.1002/advs.202407713}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2407713}, shortjournal = {Adv. Sci.}, title = {Intelligent pyroptosis inducer for precise and augmented tumor therapy through specific activation pyroptosis in tumor}, volume = {12}, year = {2025}, }
• (2025). Chemogenomic screening in a patient-derived 3D fatty liver disease model reveals the CHRM1-TRPM8 axis as a novel module for targeted intervention. ADVS, 12(3), 2407572. (www)

  @article{ , abstract = {Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of chronic liver disease with few therapeutic options. To narrow the translational gap in the development of pharmacological MASH treatments, a 3D liver model from primary human hepatocytes and non-parenchymal cells derived from patients with histologically confirmed MASH was established. The model closely mirrors disease-relevant endpoints, such as steatosis, inflammation and fibrosis, and multi-omics analyses show excellent alignment with biopsy data from 306 MASH patients and 77 controls. By combining high-content imaging with scalable biochemical assays and chemogenomic screening, multiple novel targets with anti-steatotic, anti-inflammatory, and anti-fibrotic effects are identified. Among these, activation of the muscarinic M 1 receptor (CHRM1) and inhibition of the TRPM8 cation channel result in strong anti-fibrotic effects, which are confirmed using orthogonal genetic assays. Strikingly, using biosensors based on bioluminescence resonance energy transfer, a functional interaction along a novel MASH signaling axis in which CHRM1 inhibits TRPM8 via G q/11 and phospholipase C-mediated depletion of phosphatidylinositol 4,5-bisphosphate can be demonstrated. Combined, this study presents the first patient-derived 3D MASH model, identifies a novel signaling module with anti-fibrotic effects, and highlights the potential of organotypic culture systems for phenotype-based chemogenomic drug target identification at scale.}, archive = {J_ADVS}, author = {Sonia Youhanna and Aurino M. Kemas and Shane C. Wright and Yi Zhong and Britta Klumpp and Kathrin Klein and Aikaterini Motso and Maurice Michel and Nicole Ziegler and Mingmei Shang and Pierre Sabatier and Aimo Kannt and Hongda Sheng and Nuria Oliva-Vilarnau and Florian A. Büttner and Brinton Seashore-Ludlow and Jonas Schreiner and Maike Windbergs and Martin Cornillet and Niklas K. Björkström and Andreas J. Hülsmeier and Thorsten Hornemann and Jesper V. Olsen and Yi Wang and Roberto Gramignoli and Michael Sundström and Volker M. Lauschke}, doi = {10.1002/advs.202407572}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2407572}, shortjournal = {Adv. Sci.}, title = {Chemogenomic screening in a patient-derived 3D fatty liver disease model reveals the CHRM1-TRPM8 axis as a novel module for targeted intervention}, volume = {12}, year = {2025}, }
• (2025). Synthetic retinoid sulfarotene selectively inhibits tumor-repopulating cells of intrahepatic cholangiocarcinoma via disrupting cytoskeleton by P-Selectin/PSGL1 N-glycosylation blockage. ADVS, 12(3), 2407519. (www)

  @article{ , abstract = {Intrahepatic cholangiocarcinoma (ICC) is a highly lethal malignancy that currently lacks effective clinical treatments. Eliminating stem cell-like cancer cells is an extremely promising but challenging strategy for treating ICC. A recently developed synthetic retinoid, sulfarotene, abrogates proliferation, and induces apoptosis of tumor-repopulating cells (TRCs) that exhibit stem cell-like properties, yet its effect and underlying mechanisms remain elusive in ICC. It is found that although 5-fluorouracil, cisplatin, pemigatinib, and gemcitabine all inhibit ICC-TRCs, sulfarotene demonstrates superior efficacy. Sulfarotene induces retinoic acid receptor alpha (RARɑ) translocation from the cytoplasm to the nucleus, suppressing P-selectin expression at the transcriptional level. Moreover, it directly interacts with fucosyltransferase 8 (FUT8), inhibiting the core fucosylation of P-selectin glycoprotein ligand 1 (PSGL1). These actions collectively inhibit ICC-TRCs via destroying PSGL1-regulated cytoskeleton. The findings provide a strategy of inhibiting P-selectin/PSGL1 interaction and altering PSGL1 glycosylation pattern to compromise the cytoskeletal integrity and eliminate ICC-TRCs.}, archive = {J_ADVS}, author = {Xiaojing Du and Zhuoran Qi and Sinuo Chen and Jinlan Wu and Ye Xu and Sunkuan Hu and Zhijie Yu and Jiayun Hou and Yuan Fang and Jinglin Xia and Xin Cao}, doi = {10.1002/advs.202407519}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2407519}, shortjournal = {Adv. Sci.}, title = {Synthetic retinoid sulfarotene selectively inhibits tumor-repopulating cells of intrahepatic cholangiocarcinoma via disrupting cytoskeleton by P-Selectin/PSGL1 N-glycosylation blockage}, volume = {12}, year = {2025}, }
• (2025). Viral live-attenuated vaccines (LAVs): Past and future directions. ADVS, 12(3), 2407241. (www)

  @article{ , abstract = {Viral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the adaptation of virulent viruses to novel hosts, cell cultures, or suboptimal environments, resulting in a reduction in pathogenicity while retaining immunogenicity. This process entails directed evolution of the virus to enhance its replication efficiency under these modified conditions. In this review, the development of traditional animal-adapted and cold-adapted LAVs is specially discussed. Additionally, the factors that contribute to virus attenuation from a viral lifecycle perspective are summarized. Finally, we propose future directions for next-generation LAVs.}, archive = {J_ADVS}, author = {Yan-Dong Tang and Yuming Li and Xue-Hui Cai and Xin Yin}, doi = {10.1002/advs.202407241}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2407241}, shortjournal = {Adv. Sci.}, title = {Viral live-attenuated vaccines (LAVs): Past and future directions}, volume = {12}, year = {2025}, }
• (2025). CRISPR/Cas enzyme catalysis in Liquid–Liquid phase-separated systems. ADVS, 12(3), 2407194. (www)

  @article{ , abstract = {The clustered regularly interspaced palindromic repeats (CRISPR) /CRISPR-associated proteins (Cas) system is the immune system in bacteria and archaea and has been extensively applied as a critical tool in bioengineering. Investigation of the mechanisms of catalysis of CRISPR/Cas systems in intracellular environments is essential for understanding the underlying catalytic mechanisms and advancing CRISPR-based technologies. Here, the catalysis mechanisms of CRISPR/Cas systems are investigated in an aqueous two-phase system (ATPS) comprising PEG and dextran, which simulated the intracellular environment. The findings revealed that nucleic acids and proteins tended to be distributed in the dextran-rich phase. The results demonstrated that the cis-cleavage activity of Cas12a is enhanced in the ATPS, while its trans-cleavage activity is suppressed, and this finding is further validated using Cas13a. Further analysis by increasing the concentration of the DNA reporter revealed that this phenomenon is not attributed to the slow diffusion of the reporter, and explained why Cas12a and Cas13a do not randomly cleave nucleic acids in the intracellular compartment. The study provides novel insights into the catalytic mechanisms of CRISPR/Cas systems under physiological conditions and may contribute to the development of CRISPR-based molecular biological tools.}, archive = {J_ADVS}, author = {Yaqin Zhang and Jianai Chen and Zhina Wu and Chenfei Zhao and Rui Wang and Zhiping Li and Jiasi Wang and Di Wang}, doi = {10.1002/advs.202407194}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2407194}, shortjournal = {Adv. Sci.}, title = {CRISPR/Cas enzyme catalysis in Liquid–Liquid phase-separated systems}, volume = {12}, year = {2025}, }
• (2025). Giant photoluminescence enhancement of ga-doped ZnO microwires by X-ray irradiation. ADVS, 12(3), 2407144. (www)

  @article{ , abstract = {Ga-doped zinc oxide (ZnO) microwires hold great promise for developing highly efficient light sources because of the wide bandgap with proper exciton binding energy. However, most microwires grown from one mainstream approach, i.e., chemical vapor deposition (CVD), are morphologically and crystallographically defective, exhibiting limited photoluminescence performances. Herein, a simple and effective X-ray irradiation strategy is demonstrated for enhancing the photoluminescence of Ga-doped ZnO microwire in ambient conditions. Under moderate doses (≤ 150 Gy), the photoluminescence monotonically rockets up with X-ray dose increment and achieves nine-fold enhancement at a dose of ≈150 Gy, recording high photoluminescence improvement of ZnO microwires to date. The elemental characteristics under different controlled irradiation atmospheres suggest the elimination of surface oxygen vacancy and the cross-section transmission electron microscope reveals prominent lattice relaxations after mild X-ray irradiation. In addition, the X-ray irradiated microwires further exhibit elevated electroluminescence by over three times. The enhanced photoluminescence and electroluminescence as well as long-term stability enable us to imagine the super-rapid applications of ZnO microwires in modern optoelectronic devices.}, archive = {J_ADVS}, author = {Siyuan He and Shuiyan Cao and Ying Liu and Wenfa Chen and Pin Lyu and Weidian Li and Jincheng Bao and Wenhui Sun and Caixia Kan and Mingming Jiang and Yanpeng Liu}, doi = {10.1002/advs.202407144}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2407144}, shortjournal = {Adv. Sci.}, title = {Giant photoluminescence enhancement of ga-doped ZnO microwires by X-ray irradiation}, volume = {12}, year = {2025}, }
• (2025). M6A reader PRRC2A promotes colorectal cancer progression via CK1ε-mediated activation of WNT and YAP signaling pathways. ADVS, 12(3), 2406935. (www)

  @article{ , abstract = {Colorectal cancer (CRC) is the third most common cancer type and the second highest mortality rate among cancers. However, the mechanisms underlying CRC progression remain to be fully understood. In this work, a recently identified m 6 A-modified RNA reader protein Proline-rich Coiled-coil 2a (PRRC2A) is markedly upregulated in CRC, and intestinal epithelium-specific deletion of Prrc2a significantly suppressed tumor cell growth, stemness, and migratory capacity, while its overexpression promoted these behaviors. Through multiomics analysis, PRRC2A directly targeted CSNK1E (encoding CK1ε), maintaining its RNA stability in an m 6 A-dependent manner, and that elevated CK1ε can concomitantly result in activation of the WNT and YAP signaling pathways. Interestingly, PRRC2A is directly regulated by the transcription factor ATF1 in its promoter. In summary, the work reveals a novel mechanism by which m 6 A reader PRRC2A promotes colorectal cancer progression via CK1ε and aberrant upregulation of WNT and YAP signaling. Therefore, PRRC2A and CK1ε can be potential therapeutic targets for treating CRC.}, archive = {J_ADVS}, author = {Xi Wu and Shiyang Wang and Yuwei Pan and Mengzhen Li and Manyu Song and Hanfu Zhang and Min Deng and Xu Yang and Jiuzhi Xu and Shuo Zhang and Jinhua Zhang and Fengchao Wang and Maksim V. Plikus and Cong Lv and Lu Yu and Zhengquan Yu}, doi = {10.1002/advs.202406935}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2406935}, shortjournal = {Adv. Sci.}, title = {M6A reader PRRC2A promotes colorectal cancer progression via CK1ε-mediated activation of WNT and YAP signaling pathways}, volume = {12}, year = {2025}, }
• (2025). Effects of physical exercise breaks on executive function in a simulated classroom setting: Uncovering a window into the brain. ADVS, 12(3), 2406631. (www)

  @article{ , abstract = {Acknowledging the detrimental effects of prolonged sitting, this study examined the effects of an acute exercise break during prolonged sitting on executive function, cortical hemodynamics, and microvascular status. In this randomized crossover study, 71 college students completed three conditions: (i) uninterrupted sitting (SIT); (ii) SIT with a 15 min moderate-intensity cycling break (MIC); and (iii) SIT with a 15 min vigorous-intensity cycling break (VIC). Behavioral outcomes, retinal vessel diameters (central retinal artery equivalents [CRAE], retinal vein equivalents [CRVE], arteriovenous ratio [AVR]), cortical activation, and effective connectivity were evaluated. Linear mixed models identified significant positive effects of exercise conditions on behavioral reaction time (RT), error rate, and inverse efficiency score ( β = −2.62, −0.19, −3.04: ps < 0.05). MIC and VIC conditions produced pre-to-post-intervention increases in CRAE and CRVE ( β = 4.46, 6.34), frontal activation, and resting-state and task-state causal density ( β = 0.37, 0.06) ( ps < 0.05) compared to SIT; VIC was more beneficial for executive function and neurobiological parameters. The effect of AVR on average RT was mediated through task-based causal density (indirect effect: −0.82). Acutely interrupting prolonged sitting improves executive function, microvascular status, and cortical activation and connectivity, with causal density mediating the microvascular-executive function link.}, archive = {J_ADVS}, author = {Qian Yu and Zhihao Zhang and Sebastian Ludyga and Kirk I. Erickson and Boris Cheval and Meijun Hou and Dominika M. Pindus and Charles H. Hillman and Arthur F. Kramer and Ryan S. Falck and Teresa Liu-Ambrose and Jin Kuang and Sean P. Mullen and Keita Kamijo and Toru Ishihara and David A. Raichlen and Matthew Heath and David Moreau and André O. Werneck and Fabian Herold and Liye Zou}, doi = {10.1002/advs.202406631}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2406631}, shortjournal = {Adv. Sci.}, title = {Effects of physical exercise breaks on executive function in a simulated classroom setting: Uncovering a window into the brain}, volume = {12}, year = {2025}, }
• (2025). Giant power output from ionic/electronic hybrid nanocomposite thermoelectric converter under constant temperature gradient. ADVS, 12(3), 2406589. (www)

  @article{ , abstract = {Thermoelectric (TE) materials that directly convert heat to electricity are of great significance for sustainable development. However, TE generators (TEGs) made from electronic TE materials suffer from low Seebeck coefficient (10 −2 –10 0 mV K −1 ). While ionic TE capacitors based on ionic conductors exhibit high thermovoltage (10 0 –10 2 mV K −1 ), ionic TE capacitors provide power discontinuously only under variation of temperature gradient as ions cannot transport across electrodes to external circuits. Herein, an ionic/electronic hybrid nanocomposite TE converter (NCTEC) by integrating carbon nanotube/polylactic acid nanofibrous fabrics (CPNF) with gelatin ionogel is reported. The resulting NCTEC exhibits a record-high output power density normalized by squared temperature gradient ( P ave /ΔT 2 ) of 1.72 mW m −2 K −2 and realizes continuous power output (over 12 h) at a constant temperature gradient, which is among the highest reported power output for TE converters and can be attributed to the combination of substantial increase in interfacial capacitive effect between ionogel and CPNF and an optimized electrical property of the CPNF. The work provides an effective strategy to overcome the limitations of both TEGs and ionic TE capacitors.}, archive = {J_ADVS}, author = {Siqi Liu and Mingxia Zhang and Junhua Kong and Hui Li and Chaobin He}, doi = {10.1002/advs.202406589}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2406589}, shortjournal = {Adv. Sci.}, title = {Giant power output from ionic/electronic hybrid nanocomposite thermoelectric converter under constant temperature gradient}, volume = {12}, year = {2025}, }
• (2025). Vector-free deep tissue targeting of DNA/RNA therapeutics via single capacitive discharge conductivity-clamped gene electrotransfer. ADVS, 12(3), 2406545. (www)

  @article{ , abstract = {Viral vector and lipid nanoparticle based gene delivery have limitations around spatiotemporal control, transgene packaging size, and vector immune reactivity, compromising translation of nucleic acid (NA) therapeutics. In the emerging field of DNA and particularly RNA-based gene therapies, vector-free delivery platforms are identified as a key unmet need. Here, this work addresses these challenges through gene electrotransfer (GET) of “naked” polyanionic DNA/mRNA using a single needle form-factor which supports “electro-lens” based compression of the local electric field, and local control of tissue conductivity, enabling single capacitive discharge minimal charge gene delivery. Proof-of-concept studies for “single capacitive discharge conductivity-clamped gene electrotransfer” (SCD-CC-GET) deep tissue delivery of naked DNA and mRNA in the mouse hindlimb skeletal muscle achieve stable (>18 month) expression of luciferase reporter synthetic DNA, and mRNA encoding the reporter yield rapid onset (<3 h) high transient expression for several weeks. Delivery of DNAs encoding secreted alkaline phosphatase and Cal/09 influenza virus hemagglutinin antigen generate high systemic circulating recombinant protein levels and antibody titres. The findings support adoption of SCD-CC-GET for vaccines and immunotherapies, and extend the utility of this technology to meet the demand for efficient vector-free, precision, deep tissue delivery of NA therapeutics.}, archive = {J_ADVS}, author = {Jeremy L. Pinyon and Georg von Jonquieres and Stephen L. Mow and Amr Al Abed and Keng-Yin Lai and Mathumathi Manoharan and Edward N. Crawford and Stanley H. Xue and Sarah Smith-Moore and Lisa J. Caproni and Sarah Milsom and Matthias Klugmann and Nigel H. Lovell and Gary D. Housley}, doi = {10.1002/advs.202406545}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2406545}, shortjournal = {Adv. Sci.}, title = {Vector-free deep tissue targeting of DNA/RNA therapeutics via single capacitive discharge conductivity-clamped gene electrotransfer}, volume = {12}, year = {2025}, }
• (2025). METTL16 is required for meiotic sex chromosome inactivation and DSB formation and recombination during male meiosis. ADVS, 12(3), 2406332. (www)

  @article{ , abstract = {Meiosis in males is a critical process that ensures complete spermatogenesis and genetic diversity. However, the key regulators involved in this process and the underlying molecular mechanisms remain unclear. Here, we report an essential role of the m 6 A methyltransferase METTL16 in meiotic sex chromosome inactivation (MSCI), double-strand break (DSB) formation, homologous recombination and SYCP1 deposition during male meiosis. METTL16 depletion results in a significantly upregulated transcriptome on sex chromosomes in pachytene spermatocytes and leads to reduced DSB formation and recombination, and increased SYCP1 depositioin during the first wave of spermatogenesis. Mechanistically, in pachytene spermatocytes, METTL16 interacts with MDC1/SCML2 to coordinate DNA damage response (DDR) and XY body epigenetic modifications that establish and maintain MSCI, and in early meiotic prophase I, METTL16 regulates DSB formation and recombination by regulating protein levels of meiosis-related genes. Furthermore, multi-omics analyses reveal that METTL16 interacts with translational factors and controls m 6 A levels in the RNAs of meiosis-related genes (e.g., Ubr2 ) to regulate the expression of critical meiotic regulators. Collectively, this study identified METTL16 as a key regulator of male meiosis and demonstrated that it modulates meiosis by interacting with MSCI-related factors and regulating m 6 A levels and translational efficiency (TE) of meiosis-related genes.}, archive = {J_ADVS}, author = {Lisha Yin and Nan Jiang and Wenjing Xiong and Shiyu Yang and Jin Zhang and Mengneng Xiong and Kuan Liu and Yuting Zhang and Xinxin Xiong and Yiqian Gui and Huihui Gao and Tao Li and Yi Li and Xiaoli Wang and Youzhi Zhang and Fengli Wang and Shuiqiao Yuan}, doi = {10.1002/advs.202406332}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2406332}, shortjournal = {Adv. Sci.}, title = {METTL16 is required for meiotic sex chromosome inactivation and DSB formation and recombination during male meiosis}, volume = {12}, year = {2025}, }
• (2025). Targeting the NOTCH2/ADAM10/TCF7L2 axis-mediated transcriptional regulation of wnt pathway suppresses tumor growth and enhances chemosensitivity in colorectal cancer. ADVS, 12(3), 2405758. (www)

  @article{ , abstract = {Wnt/β-catenin/transcription factor (TCF) transcriptional activity plays an integral role in colorectal cancer (CRC) carcinogenesis. However, to date, no drugs targeting this pathway are used in clinical practice owing to the undesirable and serious side effects. In this study, it is found that the transcriptional regulation of Wnt pathway is activated and associated with liver metastasis in CRC. Through high-throughput screening of 24 inhibitors on 12 CRC and three colorectal organoids in this organoid living biobank, adavivint is found to exhibit anti-tumor activity and low toxicity in colorectal organoids, independent of the canonical Wnt/β-catenin signaling. Mechanistically, ADAM10 is screened as a target of adavivint to specifically regulate the protein expression of NOTCH2, which mediates the transcriptional regulation of the Wnt pathway. NOTCH2 not directly interact with TCF7-like 2 (TCF7L2), a key downstream transcriptional factor of canonical Wnt/β-catenin signaling, but directly activated the transcription of TCF7L2 and Wnt target genes, such as MYC , JUN and CCND1/2 . Furthermore, use of adavivint or blockage of ADAM10/NOTCH2/TCF7L2 signaling enhances the chemosensitivity of CRC cells. Overall, this study provides a promising candidate for the development of small-molecule inhibitors and reveals a potential therapeutic target for CRC.}, archive = {J_ADVS}, author = {Zhen Xiang and Yiwei Wang and Xiao Ma and Shuzheng Song and Yuanqiao He and Jiamin Zhou and Longhai Feng and Su Yang and Yibin Wu and Bingran Yu and Guangkai Xia and Weiqi Xu and Yiming Zhao and Lu Wang}, doi = {10.1002/advs.202405758}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2405758}, shortjournal = {Adv. Sci.}, title = {Targeting the NOTCH2/ADAM10/TCF7L2 axis-mediated transcriptional regulation of wnt pathway suppresses tumor growth and enhances chemosensitivity in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). A chemically defined culture for tooth reconstitution. ADVS, 12(3), 2404345. (www)

  @article{ , abstract = {It is known for decades that dental epithelium and mesenchyme can reconstitute and regenerate a functional tooth. However, the mechanism of tooth reconstitution remains largely unknown due to the lack of an efficient in vitro model. Here, a chemically defined culture system is established that supports tooth reconstitution, further development with normal anatomy, and prompt response to chemical interference in key developmental signaling pathways, termed as toothoids. By using such a system, it is discovered that, during reconstitution, instead of resetting the developmental clock, dental cells reorganized and restarted from the respective developmental stage where they are originally isolated. Moreover, co-stimulation of Activin A and Hedgehog/Smoothened agonist (SAG) sustained the initial induction of tooth fate from the first branchial arch, which would be otherwise quickly lost in culture. Furthermore, activation of Bone Morphogenetic Protein (BMP) signaling triggered efficient enamel formation in the late-stage toothoids, without affecting the normal development of ameloblasts. Together, these data highlight the toothoid culture as a powerful tool to dissect the molecular mechanisms of tooth reconstitution and regeneration.}, archive = {J_ADVS}, author = {Ziwei Zhang and Hong Hu and Zhiheng Xu and Ce Shan and Hanyi Chen and Kun Xie and Kun Wang and Yifu Wang and Qing Zhu and Yike Yin and Haoyang Cai and Yunqiu Zhang and Zhonghan Li}, doi = {10.1002/advs.202404345}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2404345}, shortjournal = {Adv. Sci.}, title = {A chemically defined culture for tooth reconstitution}, volume = {12}, year = {2025}, }
• (2025). Fluorescence lifetime imaging for quantification of targeted drug delivery in varying tumor microenvironments. ADVS, 12(3), 2403253. (www)

  @article{ , abstract = {Trastuzumab (TZM) is a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) and is clinically used for the treatment of HER2-positive breast tumors. However, the tumor microenvironment can limit the access of TZM to the HER2 targets across the whole tumor and thereby compromising TZM's therapeutic efficacy. An imaging methodology that can non-invasively quantify the binding of TZM-HER2, which is required for therapeutic action, and distribution within tumors with varying tumor microenvironments is much needed. Near-infrared (NIR) fluorescence lifetime (FLI) Forster Resonance Energy Transfer (FRET) is performed to measure TZM-HER2 binding, using in vitro microscopy and in vivo widefield macroscopy, in HER2 overexpressing breast and ovarian cancer cells and tumor xenografts, respectively. Immunohistochemistry is used to validate in vivo imaging results. NIR FLI FRET in vitro microscopy data show variations in intracellular distribution of bound TZM in HER2-positive breast AU565 and AU565 tumor-passaged XTM cell lines in comparison to SKOV-3 ovarian cancer cells. Macroscopy FLI (MFLI) FRET in vivo imaging data show that SKOV-3 tumors display reduced TZM binding compared to AU565 and XTM tumors, as validated by ex vivo immunohistochemistry. Moreover, AU565/XTM and SKOV-3 tumor xenografts display different amounts and distributions of TME components, such as collagen and vascularity. Therefore, these results suggest that SKOV-3 tumors are refractory to TZM delivery due to their disrupted vasculature and increased collagen content. The study demonstrates that FLI is a powerful analytical tool to monitor the delivery of antibodydrugs both in cell cultures and in vivo live systems. Especially, MFLI FRET is a unique imaging modality that can directly quantify target engagement with the potential to elucidate the role of the TME in drug delivery efficacy in intact live tumor xenografts.}, archive = {J_ADVS}, author = {Amit Verma and Vikas Pandey and Catherine Sherry and Taylor Humphrey and Christopher James and Kailie Matteson and Jason T. Smith and Alena Rudkouskaya and Xavier Intes and Margarida Barroso}, doi = {10.1002/advs.202403253}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2403253}, shortjournal = {Adv. Sci.}, title = {Fluorescence lifetime imaging for quantification of targeted drug delivery in varying tumor microenvironments}, volume = {12}, year = {2025}, }
• (2025). Control of cellular differentiation trajectories for cancer reversion. ADVS, 12(3), 2402132. (www)

  @article{ , abstract = {Cellular differentiation is controlled by intricate layers of gene regulation, involving the modulation of gene expression by various transcriptional regulators. Due to the complexity of gene regulation, identifying master regulators across the differentiation trajectory has been a longstanding challenge. To tackle this problem, a computational framework, single-cell Boolean network inference and control (BENEIN), is presented. Applying BENEIN to human large intestinal single-cell transcriptome data, MYB, HDAC2, and FOXA2 are identified as the master regulators whose inhibition induces enterocyte differentiation. It is found that simultaneous knockdown of these master regulators can revert colorectal cancer cells into normal-like enterocytes by synergistically inducing differentiation and suppressing malignancy, which is validated by in vitro and in vivo experiments.}, archive = {J_ADVS}, author = {Jeong-Ryeol Gong and Chun-Kyung Lee and Hoon-Min Kim and Juhee Kim and Jaeog Jeon and Sunmin Park and Kwang-Hyun Cho}, doi = {10.1002/advs.202402132}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2402132}, shortjournal = {Adv. Sci.}, title = {Control of cellular differentiation trajectories for cancer reversion}, volume = {12}, year = {2025}, }
• (2025). H. pylori-facilitated TERT/Wnt/β-catenin triggers spasmolytic polypeptide-expressing metaplasia and oxyntic atrophy. ADVS, 12(3), 2401227. (www)

  @article{ , abstract = {Persistent H. pylori infection triggers the repair program of the mucosa, such as spasmolytic polypeptide-expressing metaplasia (SPEM). However, the mechanism underlying the initiation of SPEM in gastric tissues by H. pylori remains unclear. Here, an increase in telomerase reverse transcriptase (TERT) protein expression is observed in chief cells upon infection with cagA -positive H. pylori . Tert knockout significantly ameliorated H. pylori -induced SPEM and single-cell RNA sequencing demonstrated that the Wnt/β-Catenin pathway is suppressed in gastric cells with Tert knockout. Mechanism study revealed that CagA elevated TERT abundance by disrupting the interaction between TERT and its novel E3 ligase, SYVN1. Interestingly, Nitazoxanide effectively relieved SPEM via inhibition of the Wnt/β-Catenin signaling in vivo. This results clarified the mechanism underlying which CagA activated the TERT/Wnt/β-Catenin pathway, thus promoting the dedifferentiation of chief cells and the occurrence of SPEM in gastric mucosa. This highlights a molecular basis for targeting CagA-activated Wnt signaling in chief cells for the treatment of gastric precancerous lesions.}, archive = {J_ADVS}, author = {Lijiao He and Xiao Zhang and Shengwei Zhang and Yi Wang and Weichao Hu and Jie Li and Yunyi Liu and Yu Liao and Xue Peng and Jianjun Li and Haiyan Zhao and Liting Wang and Yang-Fan Lv and Chang-Jiang Hu and Shi-Ming Yang}, doi = {10.1002/advs.202401227}, journal = {Advanced Science}, month = {1}, number = {3}, pages = {2401227}, shortjournal = {Adv. Sci.}, title = {H. pylori-facilitated TERT/Wnt/β-catenin triggers spasmolytic polypeptide-expressing metaplasia and oxyntic atrophy}, volume = {12}, year = {2025}, }
• (2025). Whisker-implanted biomimetic electronic skin for tactile sensing and blind perception (Adv. sci. 2/2025). ADVS, 12(2), 2570012. (www)

  @article{ , archive = {J_ADVS}, author = {Mohammad Zarei and An Woo Jeong and Seung Goo Lee}, doi = {10.1002/advs.202570012}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2570012}, shortjournal = {Adv. Sci.}, title = {Whisker-implanted biomimetic electronic skin for tactile sensing and blind perception (Adv. sci. 2/2025)}, volume = {12}, year = {2025}, }
• (2025). Efficient predictor for immunotherapy efficacy: Detecting pan-clones effector tumor antigen-specific t cells in blood by nanoparticles loading whole tumor antigens (Adv. sci. 2/2025). ADVS, 12(2), 2570011. (www)

  @article{ , archive = {J_ADVS}, author = {Weibiao Zeng and Jin Wang and Zhike Chen and Jian Yang and Ao Zhu and Yan Zheng and Xianlan Chen and Yuhan Liu and Leilei Wu and Yufeng Xie and Sheng Ju and Jun Chen and Cheng Ding and Chang Li and Xin Tong and Mi Liu and Jun Zhao}, doi = {10.1002/advs.202570011}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2570011}, shortjournal = {Adv. Sci.}, title = {Efficient predictor for immunotherapy efficacy: Detecting pan-clones effector tumor antigen-specific t cells in blood by nanoparticles loading whole tumor antigens (Adv. sci. 2/2025)}, volume = {12}, year = {2025}, }
• (2025). 1,8-diazabicyclo[5.4.0]undec-7-ene as cyclic ether electrolyte polymerization inhibition for wide-temperature-range high-rate lithium-ion batteries (Adv. sci. 2/2025). ADVS, 12(2), 2570010. (www)

  @article{ , archive = {J_ADVS}, author = {Hui Tian and Zixin Hong and Zhenhan Fang and Yufeng Luo and Hengcai Wu and Fei Zhao and Qunqing Li and Shoushan Fan and Jiaping Wang}, doi = {10.1002/advs.202570010}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2570010}, shortjournal = {Adv. Sci.}, title = {1,8-diazabicyclo[5.4.0]undec-7-ene as cyclic ether electrolyte polymerization inhibition for wide-temperature-range high-rate lithium-ion batteries (Adv. sci. 2/2025)}, volume = {12}, year = {2025}, }
• (2025). Dual-modal sensing skin adaptive to daylight, darkness, and ultraviolet light for simultaneous full-field deformation measurement and mechanoluminescence responses (Adv. sci. 2/2025). ADVS, 12(2), 2570009. (www)

  @article{ , archive = {J_ADVS}, author = {Suman Timilsina and Cheol Woo Jo and Kwang Ho Lee and Kee-Sun Sohn and Ji Sik Kim}, doi = {10.1002/advs.202570009}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2570009}, shortjournal = {Adv. Sci.}, title = {Dual-modal sensing skin adaptive to daylight, darkness, and ultraviolet light for simultaneous full-field deformation measurement and mechanoluminescence responses (Adv. sci. 2/2025)}, volume = {12}, year = {2025}, }
• (2025). Total electrosynthesis of n, N-dimethylformamide from CO2 and NO3−. ADVS, 12(2), 2414431. (www)

  @article{ , abstract = {Electrochemical C−N coupling presents a promising strategy for converting abundant small molecules like CO 2 and NO 3 − to produce low-carbon-intensity chemicals in a potentially more sustainable route. A prominent challenge is the limited product scope, particularly for organonitrogen chemicals featuring a variety of functional groups, alongside the limited understanding of plausible reaction mechanisms leading up to these products. In light of this, the total electrosynthesis method is reported for producing N, N-dimethylformamide (DMF), a widespread solvent and commodity chemical, from NO 3 − and CO 2 . This method enabled a notable production rate of 1.24 mmol h −1 g cat −1 for DMF employing a hybrid Ag/Cu catalyst. Additionally, an impressive Faradaic efficiency (FE) of 28.6% is attained for DMF through oxidative coupling of dimethylamine using Ag/Cu catalyst. Through a distinctive retrosynthetic experimental analysis, the DMF synthesis pathway is systematically deconstructed, tracing its origins from dimethylamine to methylamine, and ultimately to CO 2 and NO 3 − . The investigation revealed that the hydrogenation of coupled intermediates proves to be the limiting step, rather than the C−N coupling steps in the synthetic pathway. Finally, using a combination of in situ measurements and retrosynthetic analysis, the possible mechanism is elucidated underlying DMF synthesis and identified subsequent routes for system improvement.}, archive = {J_ADVS}, author = {Shuai Yan and Shuai Chen and Morgan McKee and Alexandre Terry and Ralf Weisbarth and Nikolay Kornienko}, doi = {10.1002/advs.202414431}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2414431}, shortjournal = {Adv. Sci.}, title = {Total electrosynthesis of n, N-dimethylformamide from CO2 and NO3−}, volume = {12}, year = {2025}, }
• (2025). Correction to “Dyslexia-related hearing loss occurs mainly through the abnormal spontaneous electrical activity of spiral ganglion neurons”. ADVS, 12(2), 2413887. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202413887}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2413887}, shortjournal = {Adv. Sci.}, title = {Correction to “Dyslexia-related hearing loss occurs mainly through the abnormal spontaneous electrical activity of spiral ganglion neurons”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Metal-free and open-air arylation reactions of diaryliodonium salts for DNA-encoded library synthesis”. ADVS, 12(2), 2413292. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202413292}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2413292}, shortjournal = {Adv. Sci.}, title = {Correction to “Metal-free and open-air arylation reactions of diaryliodonium salts for DNA-encoded library synthesis”}, volume = {12}, year = {2025}, }
• (2025). Nanoengineering of Phosphate/Phosphonate drugs via competitive replacement with metal-phenolic networks to overcome breast tumor with lung and bone metastasis. ADVS, 12(2), 2413201. (www)

  @article{ , abstract = {Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, and exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, and enzyme-inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for nanoengineering phosphate/phosphonate drugs is introduced. By leveraging the difference in coordination capabilities between polyphenols and phosphates/phosphonates with metal ions, various phosphate/phosphonate-based nanodrugs using metal-phenolic networks (MPNs) as templates and phosphate/phosphonate drugs as competitive agents are constructed. The dynamic nature of these coordination bonds imparts stimuli-responsiveness to the nanodrugs, allowing for targeted release and therapy. As a proof of concept, Fe 3+ and galangin are used to form the MPN template, zoledronic acid and cGAMP as competitive agents, and DOX as the loaded drug to construct DOX@Fe-galangin@Fe-zoledronic acid-cGAMP nanodrugs. The results demonstrate that, by triggering pyroptosis and activating the cGAS-STING pathway, the nanodrugs exhibit potent cytotoxicity and accurate selectivity in eradicating orthotopic breast tumors, and activate an antitumor immune response against lung and bone metastases. Because the competitive coordination strategy is applicable to a variety of phosphate/phosphonate agents, it holds significant potential for enhancing the clinical efficacy of phosphate/phosphonate drugs and advancing nanodrug development for complex therapeutic applications.}, archive = {J_ADVS}, author = {Wanrui Shi and Dashuai Liu and Wenjie Feng and Yang Chen and Yonggang Wang and Zhihong Nie and Yi Liu and Hao Zhang}, doi = {10.1002/advs.202413201}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2413201}, shortjournal = {Adv. Sci.}, title = {Nanoengineering of Phosphate/Phosphonate drugs via competitive replacement with metal-phenolic networks to overcome breast tumor with lung and bone metastasis}, volume = {12}, year = {2025}, }
• (2025). Comprehensive modular synthesis of ganglioside glycans and evaluation of their binding affinities to siglec-7 and siglec-9. ADVS, 12(2), 2412815. (www)

  @article{ , abstract = {In the present work, bacterial glycosyltransferases are utilized to construct ganglioside glycans in a convergent approach via a sugar‒nucleotide regeneration system and one-pot multienzyme reactions. Starting from β-lactoside enables the diversification of both the glycan moieties and the linkages in the lower α-arm and upper β-arm. Overall, a comprehensive panel of 24 natural a-series (GM3, GM2, GM1a, GD1a, GT1a, and fucosyl-GM1), b-series (GD3, GD2, GD1b, GT1b, and GQ1b), c-series (GT3, GT2, GT1c, GQ1c, and GP1c), α-series (GM1α, GD1aα, and GT1aα), and o-series (GA2, GA1, GM1b, GalNAc-GM1b, and GD1c) ganglioside glycans are prepared, which are suitable for biological studies and further applications. Moreover, a microarray is constructed with these synthesized ganglioside glycans to investigate their binding specificity with recombinant Fc-fused Siglec-7 and Siglec-9, which are immune checkpoint-like glycan recognition proteins on natural killer cells. The microarray binding results reveal that GD3 and GT1aα are specific ligands for Siglec-7 and Siglec-9, respectively, and this discovery can lead to the identification of appropriate ligands for investigating the roles of these Siglecs in immunomodulation.}, archive = {J_ADVS}, author = {Avijit K. Adak and Hsin-Kai Tseng and Shu-Yen Chang and Yu-Ching Chiang and Ke-Hong Lyu and Yun-Sheng Lee and Wen Lu and Wen-Hua Kuo and Takashi Angata and Chun-Cheng Lin}, doi = {10.1002/advs.202412815}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2412815}, shortjournal = {Adv. Sci.}, title = {Comprehensive modular synthesis of ganglioside glycans and evaluation of their binding affinities to siglec-7 and siglec-9}, volume = {12}, year = {2025}, }
• (2025). Retraction: A stress self-adaptive Silicon/Carbon “Ordered structures” to suppress the electro-chemo-mechanical failure: Piezo-electrochemistry and piezo-ionic dynamics. ADVS, 12(2), 2412738. (www)

  @article{ , abstract = {H. Zhao, K. Liang, S. Wang, Z. Ding, X. Huang, W. Chen, Y. Ren, and J. Li, “A Stress Self-Adaptive Silicon/Carbon “Ordered Structures” to Suppress the Electro-Chemo-Mechanical Failure: Piezo-Electrochemistry and Piezo-Ionic Dynamics,” Advanced Science 10, no. 29 (2023): 2303696. https://doi.org/10.1002/advs.202303696 The above article, published online on 21 August 2023 in Wiley Online Library ( wileyonlinelibrary.com ), has been retracted by agreement between the authors; the journal Editor-in-Chief, Kirsten Severing; and Wiley-VCH GmbH. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate duplication of image panels (Figures 2j, 3h,i, and 6, and Figures S4, S5, and S13a, Supporting Information) between this article and other articles that were previously published in a different scientific context. Due to the number and the level of inconsistencies identified in the published figures, the editors consider the conclusions of this manuscript substantially compromised. The corresponding authors, Y. Ren and J. Li, asked to retract the article due to misused figures, because of which they cannot guarantee the validity of the data and the conclusions.}, archive = {J_ADVS}, doi = {10.1002/advs.202412738}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2412738}, shortjournal = {Adv. Sci.}, title = {Retraction: A stress self-adaptive Silicon/Carbon “Ordered structures” to suppress the electro-chemo-mechanical failure: Piezo-electrochemistry and piezo-ionic dynamics}, volume = {12}, year = {2025}, }
• (2025). Synthesis of homochiral N-heterocyclic carbene-based nanosheets for enhanced asymmetric catalysis. ADVS, 12(2), 2412592. (www)

  @article{ , abstract = {Utilizing ultrathin 2D metal–organic framework nanosheets (2D MONs) as supports for incorporating chiral catalysts represents a highly promising avenue in the field of asymmetric catalysis. In this study, four pairs of isostructural chiral metal–organic layers (MOLs) adorned with N -Heterocyclic carbene (NHC) groups are successfully synthesized. Notably, the obtained bulky ( S )-1-Zn crystals can be readily delaminated into ultrathin MONs consisting of 1–2 layers through an ion intercalation-assisted exfoliation process. Subsequent asymmetric catalysis studies revealed that the NHC sites can be effectively activated by a proton sponge while maintaining structural integrity for the subsequent benzoin condensation. Due to their well-exposed catalytic sites, ultrathin morphology, and porous structure, the ( S )-1-Zn nanosheets exhibited significantly enhanced yield and enantioselectivity compared to their bulk counterparts and organic precursors. This research highlights an efficient strategy for incorporating chiral NHC species onto 2D MONs, thereby unlocking their immense potential for heterogeneous asymmetric catalysis.}, archive = {J_ADVS}, author = {Xinchao Wang and Zhiwen Wang and Zhaoxing Wang and Tian-Fu Liu and Shangda Li and Fei Wang and Jian Zhang}, doi = {10.1002/advs.202412592}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2412592}, shortjournal = {Adv. Sci.}, title = {Synthesis of homochiral N-heterocyclic carbene-based nanosheets for enhanced asymmetric catalysis}, volume = {12}, year = {2025}, }
• (2025). ScPharm: Identifying pharmacological subpopulations of single cells for precision medicine in cancers. ADVS, 12(2), 2412419. (www)

  @article{ , abstract = {Intratumour heterogeneity significantly hinders the efficacy of anticancer therapies. Compared with drug perturbation experiments, which yield pharmacological data at the bulk cell level, single-cell RNA sequencing (scRNA-seq) technology provides a means to capture molecular heterogeneity at single-cell resolution. Here, scPharm is introduced, a computational framework that integrates pharmacological profiles with scRNA-seq data to identify pharmacological subpopulations of cells within a tumour and prioritize tailored drugs. scPharm uses the normalized enrichment scores (NESs) determined from gene set enrichment analysis to assess the distribution of cell identity genes in drug response-determined gene lists. Based on the strong correlation between the NES and drug response at single-cell resolution, scPharm successfully identified the sensitive subpopulations in ER-positive and HER2-positive human breast cancer tissues, revealed dynamic changes in the resistant subpopulation of human PC9 cells treated with erlotinib, and expanded its ability to a mouse model. Its superior performance and computational efficiency are confirmed through comparative evaluations with other single-cell prediction tools. Additionally, scPharm predicted combination drug strategies by gauging compensation or booster effects between drugs and evaluated drug toxicity in healthy cells in the tumour microenvironment. Overall, scPharm provides a novel approach for precision medicine in cancers by revealing therapeutic heterogeneity at single-cell resolution.}, archive = {J_ADVS}, author = {Peng Tian and Jie Zheng and Keying Qiao and Yuxiao Fan and Yue Xu and Tao Wu and Shuting Chen and Yinuo Zhang and Bingyue Zhang and Chiara Ambrogio and Haiyun Wang}, doi = {10.1002/advs.202412419}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2412419}, shortjournal = {Adv. Sci.}, title = {ScPharm: Identifying pharmacological subpopulations of single cells for precision medicine in cancers}, volume = {12}, year = {2025}, }
• (2025). Ultrafast sintering of dense Li7La3Zr2O12 membranes for li metal all-solid-state batteries. ADVS, 12(2), 2412370. (www)

  @article{ , abstract = {Ultrafast sintering (UFS) is a compelling approach for fabricating Li 7 La 3 Zr 2 O 12 (LLZO) solid-state electrolytes (SSEs), paving the way for advancing and commercializing Li-garnet solid-state batteries. Although this method is commonly applied to the sintering of LLZO ceramics, its use for producing dense, phase-pure LLZO SSEs has thus far been primarily limited to millimeter-thick pellets, which are unsuitable for commercial solid-state batteries. This study presents ultrafast sintering as a highly effective approach for fabricating self-standing, dense, 45 µm-thick LLZO membranes. The chemical and structural evolution of LLZO membranes during the UFS process is characterized through in situ synchrotron X-ray diffraction and thermogravimetric analysis-mass spectrometry, complemented by an in-depth investigation of surface chemistry using X-ray photoelectron spectroscopy. The membranes in Li/LLZO/Li symmetrical cell configuration exhibit a high critical current density of up to 12.5 mA cm −2 and maintain superior cycling stability for 250 cycles at a current density of 1 mA cm −2 , with an areal capacity limit of 1 mAh cm −2 . The electrochemical performance of LLZO membranes is also assessed in full cell configuration using a pyrochlore-type iron (III) hydroxy fluoride cathode.}, archive = {J_ADVS}, author = {Faruk Okur and Huanyu Zhang and Julian F. Baumgärtner and Jaka Sivavec and Matthias Klimpel and Gregor Paul Wasser and Romain Dubey and Lars P.H. Jeurgens and Dmitry Chernyshov and Wouter van Beek and Kostiantyn V. Kravchyk and Maksym V. Kovalenko}, doi = {10.1002/advs.202412370}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2412370}, shortjournal = {Adv. Sci.}, title = {Ultrafast sintering of dense Li7La3Zr2O12 membranes for li metal all-solid-state batteries}, volume = {12}, year = {2025}, }
• (2025). Innovative hydrogel design: Tailoring immunomodulation for optimal chronic wound recovery. ADVS, 12(2), 2412360. (www)

  @article{ , abstract = {Despite significant progress in tissue engineering, the full regeneration of chronic wounds persists as a major challenge, with the immune response to tissue damage being a key determinant of the healing process's quality and duration. Post-injury, a crucial aspect is the transition of macrophages from a pro-inflammatory state to an anti-inflammatory. Thus, this alteration in macrophage polarization presents an enticing avenue within the realm of regenerative medicine. Recent advancements have entailed the integration of a myriad of cellular and molecular signals into hydrogel-based constructs, enabling the fine-tuning of immune cell activities during different phases. This discussion explores modern insights into immune cell roles in skin regeneration, underscoring the key role of immune modulation in amplifying the overall efficacy of wounds. Moreover, a comprehensive review is presented on the latest sophisticated technologies employed in the design of immunomodulatory hydrogels to regulate macrophage polarization. Furthermore, the deliberate design of hydrogels to deliver targeted immune stimulation through manipulation of chemistry and cell integration is also emphasized. Moreover, an overview is provided regarding the influence of hydrogel properties on immune traits and tissue regeneration process. Conclusively, the accent is on forthcoming pathways directed toward modulating immune responses in the milieu of chronic healing.}, archive = {J_ADVS}, author = {Chun-Mei Lai and Wei-Ji Chen and Yuan Qin and Di Xu and Yue-Kun Lai and Shao-Hua He}, doi = {10.1002/advs.202412360}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2412360}, shortjournal = {Adv. Sci.}, title = {Innovative hydrogel design: Tailoring immunomodulation for optimal chronic wound recovery}, volume = {12}, year = {2025}, }
• (2025). Microglial lyzl4 facilitates β-amyloid clearance in alzheimer's disease. ADVS, 12(2), 2412184. (www)

  @article{ , abstract = {Alzheimer's Disease (AD) is a neurodegenerative condition characterized by the accumulation and deposition of amyloid-β (Aβ) aggregates in the brain. Despite a wealth of research on the toxicity of Aβ and its role in synaptic damage, the mechanisms facilitating Aβ clearance are not yet fully understood. However, microglia, the primary immune cells of the central nervous system, are known to maintain homeostasis through the phagocytic clearance of protein aggregates and cellular debris. In this study, RNA sequencing analysis and live cell functional screens are employed to uncover microglial genetic modifiers related to AD. Lyzl4 is identified, which encodes a c-type lysozyme-like enzyme primarily localized to microglial lysosomes, as a gene significantly upregulated in AD microglia with aging and propose that Lyzl4 upregulation acts as a positive regulator of Aβ clearance. Furthermore, it is found that Lyzl4 overexpression boosts Aβ clearance both in vitro and in vivo, underscoring its potential for mitigating Aβ burden. These novel insights position Lyzl4 as a promising therapeutic target for Alzheimer's disease, paving the way for further exploration into potential AD treatments.}, archive = {J_ADVS}, author = {Jie Pan and Jie Zhong and Ji Geng and Jane Oberhauser and Shihua Shi and Jun Wan}, doi = {10.1002/advs.202412184}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2412184}, shortjournal = {Adv. Sci.}, title = {Microglial lyzl4 facilitates β-amyloid clearance in alzheimer's disease}, volume = {12}, year = {2025}, }
• (2025). Nanostructure-mediated photothermal effect for reinforcing physical killing activity of nanorod arrays. ADVS, 12(2), 2411997. (www)

  @article{ , abstract = {The physical killing of bacteria based on surface topography has attracted much attention due to the sustainable and safe prevention of biofilm formation. However, the antibacterial efficiency of biomedical implants derived solely from nanostructures or microstructures is insufficient to combat bacteria against common infections, such as methicillin-resistant Staphylococcus aureus with thick cell walls. Herein, photothermal therapy is carried out in the presence of nanorod arrays to mitigate infection of biomedical implants. Different from traditional photothermal therapy relying on a photosensitizer, the photothermal effect is mediated by light traps rendered by the nanorod arrays, and consequently, the photosensitizer is not needed. Finite element simulations and experiments are performed to elucidate the light-to-thermal conversion mechanism. This photothermal platform, in conjunction with thermosensitive nitric oxide therapy, is applied to treat titanium implant infection. The nanostructure-mediated photothermal effect destroys bacterial cell walls by inhibiting peptidoglycan synthesis and increasing the membrane permeability by affecting fatty acid synthesis. Furthermore, the nanorods synergistically puncture the bacterial membrane easily as demonstrated by experiments and transcriptome analysis. The results provide insights into the development of efficient antibacterial treatment of implants by combining nanostructures and photothermal therapy.}, archive = {J_ADVS}, author = {Guannan Zhang and Zehao Li and Menlin Sun and Ying Lu and Jianbo Song and Wangping Duan and Xiaobo Huang and Ruiqiang Hang and Xiaohong Yao and Paul K Chu and Xiangyu Zhang}, doi = {10.1002/advs.202411997}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411997}, shortjournal = {Adv. Sci.}, title = {Nanostructure-mediated photothermal effect for reinforcing physical killing activity of nanorod arrays}, volume = {12}, year = {2025}, }
• (2025). Optimizing reversible phase-transformation of FeS2 anode via atomic-interface engineering toward fast-charging sodium storage: Theoretical predication and experimental validation. ADVS, 12(2), 2411884. (www)

  @article{ , abstract = {Sodium-storage performance of pyrite FeS 2 is greatly improved by constructing various FeS 2 -based nanostructures to optimize its ion-transport kinetics and structural stability. However, less attention has been paid to rapid capacity degradation and electrode failure caused by the irreversible phase-transition of intermediate Na x FeS 2 to FeS 2 and polysulfides dissolution upon cycling. Under the guidance of theoretical calculations, coupling FeS 2 nanoparticles with honeycomb-like nitrogen-doped carbon (NC) nanosheet supported single-atom manganese (SAs Mn) catalyst (FeS 2 /SAs Mn@NC) via atomic-interface engineering is proposed to address above challenge. Systematic electrochemical analyses and theoretical results unveil that the functional integration of such two type components can significantly enhance ionic conductivity, accelerate charge transfer efficiency, and improve Na + -adsorption capability. Particularly, SAs Mn@NC with Mn-N x coordination center can reduce the decomposition barrier of Na 2 S and Na x FeS 2 to further accelerate reversible phase transformation of Fe/Na 2 S→NaFeS 2 →FeS 2 and polysulfides decomposition. As predicted, such FeS 2 /SAs Mn@NC showcases outstanding rate capability and fascinating cyclic durability. A sequence of kinetic studies and ex situ characterizations provide the comprehensive understanding for ion-transport kinetics and phase-transformation process. Its practical use is further demonstrated in sodium-ion full cell and capacitor with impressive electrochemical capability and excellent energy-density output.}, archive = {J_ADVS}, author = {Wenxi Zhao and Yanbing Zhou and Hao Zhou and Xinqin Wang and Shengjun Sun and Xun He and Yongsong Luo and Binwu Ying and Yongchao Yao and Xiaoqing Ma and Xuping Sun}, doi = {10.1002/advs.202411884}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411884}, shortjournal = {Adv. Sci.}, title = {Optimizing reversible phase-transformation of FeS2 anode via atomic-interface engineering toward fast-charging sodium storage: Theoretical predication and experimental validation}, volume = {12}, year = {2025}, }
• (2025). Biomimetic dehydrogenative intermolecular formal allylic amidation of branched α-olefins. ADVS, 12(2), 2411744. (www)

  @article{ , abstract = {Allylic amide moieties are commonly encountered in natural products and are privileged structures in pharmaceuticals and agrochemicals. Moreover, because allylic amide can be to converted into an array of high-value motifs, they have been widely employed in organic synthesis. However, the development of catalytic systems for intermolecular allylic amidation of olefins, particularly branched α -olefins, has proven to be challenging. Here, a biomimetic, synergistic catalytic method is reported that combines photoredox, cobalt, and Brønsted base catalysis for the synthesis of substituted allylic amides from branched α -olefins and simple imides without using oxidants. This low-cost, operationally simple method features a broad substrate scope and excellent functional group compatibility. Moreover, it is successfully used for the functionalization of several structurally complex molecules demonstrating the method's potential utility for medicinal chemistry applications. Mechanistic studies revealed that C( sp 3 )─N bond formation is mediated by a nitrogen-centered radical intermediate, which is generated via a sequence involving deprotonation and single-electron oxidation.}, archive = {J_ADVS}, author = {Xiaoyang Fu and Jiarui Tian and Mingjun Zhang and Yue Jing and Yuxiu Liu and Hongjian Song and Qingmin Wang}, doi = {10.1002/advs.202411744}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411744}, shortjournal = {Adv. Sci.}, title = {Biomimetic dehydrogenative intermolecular formal allylic amidation of branched α-olefins}, volume = {12}, year = {2025}, }
• (2025). Isolated rhodium atoms activate porous TiO2 for enhanced electrocatalytic conversion of nitrate to ammonia. ADVS, 12(2), 2411705. (www)

  @article{ , abstract = {The direct electrochemical reduction of nitrate to ammonia is an efficient and environmentally friendly technology, however, developing electrocatalysts with high activity and selectivity remains a great challenge. Single-atom catalysts demonstrate unique properties and exceptional performance across a range of catalytic reactions, especially those that encompass multi-step processes. Herein, a straightforward and cost-effective approach is introduced for synthesizing single-atom dispersed Rh on porous TiO 2 spheres (Rh 1 -TiO 2 ), which functions as an efficient electrocatalyst for the electroreduction of NO 3 − to NH 3 . The synthesized Rh 1 -TiO 2 catalyst achieve a maximum NH 3 Faradaic efficiency (FE) of 94.7% and an NH 3 yield rate of 29.98 mg h −1 mg cat −1 at −0.5 V versus RHE in a 0.1 M KOH+0.1 M KNO 3 electrolyte, significantly outperforming not only undoped TiO 2 but also Ru, Pd, and Ir single-atom doped titania catalysts. Density functional theory calculations reveal that the incorporation of Rh single atom significantly enhances charge transfer between adsorbed NO 3 − and the active site. The Rh atoms not only serve as the highly active site for electrochemical nitrate reduction reaction (NO 3 RR), but also activates the adjacent Ti sites through optimizating the electronic structure, thereby reducing the energy barrier of the rate-limiting step. Consequently, this results in a substantial enhancement in electrochemical NO 3 RR performance. Furthermore, this synthetic method has the potential to be extended to other single-atom catalysts and scaled up for commercial applications.}, archive = {J_ADVS}, author = {Zhi Liang Zhao and Shaoxuan Yang and Shensong Wang and Zhe Zhang and Liang Zhao and Qi Wang and Xinyi Zhang}, doi = {10.1002/advs.202411705}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411705}, shortjournal = {Adv. Sci.}, title = {Isolated rhodium atoms activate porous TiO2 for enhanced electrocatalytic conversion of nitrate to ammonia}, volume = {12}, year = {2025}, }
• (2025). Modulation of the nernst thermoelectrics by regulating the anomalous hall and nernst angles. ADVS, 12(2), 2411702. (www)

  @article{ , abstract = {The large anomalous Nernst effect in magnetic Weyl semimetals is one of the most intriguing transport phenomena, which draws significant attention for its potential applications in topological thermoelectrics. Despite frequent reports of substantial anomalous Nernst conductivity (ANC), methods to optimize Nernst thermoelectrics remain limited. The research reveals that the magnitude of the ANC is directly related to the sum of the anomalous Nernst and Hall angles. While the sign of the anomalous Hall angle is relatively stable in a certain material, the sign of the anomalous Nernst angle can be intrinsically tuned. Therefore, the ANC can be effectively optimized by regulating these angles to work in concert. This finding is verified by experimental modulation from iron-doped magnetic topological material Co 3 Sn 2 S 2 . Additionally, a robust T ln T scaling law of the ANC over the temperature range of 40 to 140 K is observed in all studied samples, suggesting an intrinsic origin of the ANC. Considering the common opposite sign of the anomalous Nernst and Hall angles in many magnetic topological materials, the research offers an applicable scheme for optimizing the Nernst thermoelectrics.}, archive = {J_ADVS}, author = {Meng Lyu and Junyan Liu and Jianlei Shen and Shen Zhang and Yang Liu and Jinying Yang and Yibo Wang and Yiting Feng and Binbin Wang and Hongxiang Wei and Enke Liu}, doi = {10.1002/advs.202411702}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411702}, shortjournal = {Adv. Sci.}, title = {Modulation of the nernst thermoelectrics by regulating the anomalous hall and nernst angles}, volume = {12}, year = {2025}, }
• (2025). 3D crystal construction by single-crystal 2D material supercell multiplying. ADVS, 12(2), 2411656. (www)

  @article{ , abstract = {2D stacking presents a promising avenue for creating periodic superstructures that unveil novel physical phenomena. While extensive research has focused on lateral 2D material superstructures formed through composition modulation and twisted moiré structures, the exploration of vertical periodicity in 2D material superstructures remains limited. Although weak van der Waals interfaces enable layer-by-layer vertical stacking, traditional methods struggle to control in-plane crystal orientation over large areas, and the vertical dimension is constrained by unscalable, low-throughput processes, preventing the achievement of global order structures. In this study, a supercell multiplying approach is introduced that enables high-throughput construction of 3D superstructures on a macroscopic scale, utilizing artificially stacked single-crystalline 2D multilayers as foundational repeating units. By employing wafer-scale single-crystalline 2D materials and referencing the crystal orientation of substrates, the method ensures precise alignment of crystal orientation within and across each supercell, thereby achieving controllable periodicity along all three axes. A centimeter-scale 3R-MoS₂ crystal is successfully constructed, comprising over 200 monolayers of single-crystalline MoS₂, through a bottom-up stacking process. Additionally, the approach accommodates the integration of amorphous oxide, enabling the assembly of 3D non-linear optical crystals with quasi-phase matching. This method paves the way for the bottom-up construction of macroscopic artificial 3D crystals with atomic plane precision, enabling tailored optical, electrical, and thermal properties and advancing the development of novel artificial materials and high-performance applications.}, archive = {J_ADVS}, author = {Wenhao Li and Jichuang Shen and Yaqing Ma and Xiang Xu and Han Chen and Lida Yu and Chen Ji and Menglin He and Kezhao Ma and Yiwei Duo and Li Wang and Tongbo Wei and Liping Shi and Muhong Wu and Kaihui Liu and Huaze Zhu and Wei Kong}, doi = {10.1002/advs.202411656}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411656}, shortjournal = {Adv. Sci.}, title = {3D crystal construction by single-crystal 2D material supercell multiplying}, volume = {12}, year = {2025}, }
• (2025). Stabilized carbon radical-mediated assembly of arylthianthrenium salts, alkenes and amino Acid/Peptide derivatives. ADVS, 12(2), 2411579. (www)

  @article{ , abstract = {Efficiently assembling amino acids and peptides with bioactive molecules facilitates the modular and streamlined synthesis of a diverse library of peptide-related compounds. Particularly notable is their application in pharmaceutical development, leveraging site-selective late-stage functionalization. Here, a visible light-induced three-component reaction involving arylthianthrenium salts, amino acid/peptide derivatives, and alkenes are introduced. This approach utilizes captodatively-stabilized carbon radicals to enable radical-radical C─C coupling, effectively constructing complex bioactive molecules. This method offers a promising alternative route for modular synthesis of peptide-derived bio-relevant compounds}, archive = {J_ADVS}, author = {Bo Dong and Weiguan Qi and Yifeng Chen and Yufei Zhang and Shiyu Gu and Jianlin Zhao and Qingfa Zhou and Jian Shen and Lan-Gui Xie}, doi = {10.1002/advs.202411579}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411579}, shortjournal = {Adv. Sci.}, title = {Stabilized carbon radical-mediated assembly of arylthianthrenium salts, alkenes and amino Acid/Peptide derivatives}, volume = {12}, year = {2025}, }
• (2025). Ultrawide spectrum metallic plane blackbody with extremely high absorption from 0.2 to 25 µm. ADVS, 12(2), 2411448. (www)

  @article{ , abstract = {A plane blackbody serves as a standard radiation source, providing a precise quantitative relationship between input radiation and the output of infrared detectors, which is essential component of space infrared remote sensing instruments. However, current plane blackbodies fabricated by coating or surface structuring are unable to achieve uniform and stable high absorption in the ultrawide spectral range spanning the UV-VIS-NIR-MIR. Here, a femtosecond laser “V”- scanning method is proposed for the fabrication of cross-scale multi-layered micro- and nanocomposite structures on copper surfaces to realize ultrawide spectrum metallic plane blackbody with high absorption. The structures consist of a micrometer cone-tip structure with a depth-to-width ratio of 7:1 (period 30 µm, depth 210 µm), an oxide layer with a thickness of more than 2 µm, and nanoparticles of different sizes, achieving uniform high absorption rates exceeding 99% in the localized spectral range of 400–700 nm and over 98% from the UV to MIR range of 200 nm to 25 µm. This strategy offers a generalized approach to enhance surface light absorption, with significant application potential in infrared calibration, passive radiation cooling, and stray light suppression.}, archive = {J_ADVS}, author = {Jin-Yong Qi and Xue-Qing Liu and Zi-Jian Liu and Xin Zhang and Chao Li and Qi-Dai Chen and Lei Wang and Hong-Bo Sun}, doi = {10.1002/advs.202411448}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411448}, shortjournal = {Adv. Sci.}, title = {Ultrawide spectrum metallic plane blackbody with extremely high absorption from 0.2 to 25 µm}, volume = {12}, year = {2025}, }
• (2025). Aligned hollow silicon nanorods containing ionic liquid enhanced solid polymer electrolytes with superior cycling and rate performance. ADVS, 12(2), 2411437. (www)

  @article{ , abstract = {The low lithium-ion conductivity of polyethylene oxide (PEO)-based polymer electrolytes limits their application in solid-state lithium batteries and related fields. Here, ionic liquids (ILs) are injected into hollow silicon nanorods (HSNRs) to prepare a composite solid polymer electrolyte (CSPE) with aligned HSNRs containing ILs (F-ILs@HSNRs). Applying a magnetic field promoted uniform dispersion and orientation of F-ILs@HSNRs in CSPE. The addition of F-ILs@HSNRs reduced PEO crystallinity and formed Li + transport pathways at the F-ILs@HSNRs/PEO interface. Calculations and multi-physics simulations reveal that ILs within F-ILs@HSNRs contribute most to lithium-ion conduction, followed by the F-ILs@HSNRs/PEO interface. When F-ILs@HSNRs are arranged perpendicular to the electrodes, the CSPE exhibits the shortest Li + migration pathways, resulting in stable and efficient lithium-ion conduction. The conductivity (2.14 × 10 −4 S cm −1 ) and lithium-ion migration number t Li+ (0.307) are the highest, being 125 times and 184% higher, respectively, than those of PEO-LiTFSI, when compared to CSPEs with randomly arranged or parallel-aligned F-ILs@HSNRs. Furthermore, Li|CSPE|Li batteries and LiFePO 4 |CSPE|Li batteries display stable cycling for over 2000 h, with coulombic efficiency approaching 100%. Excellent electrochemical reversibility is also confirmed in the rate performance test.}, archive = {J_ADVS}, author = {Xinglong Gao and Zhong Zheng and Yifan Pan and Shuyi Song and Zhen Xu}, doi = {10.1002/advs.202411437}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411437}, shortjournal = {Adv. Sci.}, title = {Aligned hollow silicon nanorods containing ionic liquid enhanced solid polymer electrolytes with superior cycling and rate performance}, volume = {12}, year = {2025}, }
• (2025). Wearable electrochemical biosensors for advanced healthcare monitoring. ADVS, 12(2), 2411433. (www)

  @article{ , abstract = {Recent advancements in wearable electrochemical biosensors have opened new avenues for on-body and continuous detection of biomarkers, enabling personalized, real-time, and preventive healthcare. While glucose monitoring has set a precedent for wearable biosensors, the field is rapidly expanding to include a wider range of analytes crucial for disease diagnosis, treatment, and management. In this review, recent key innovations are examined in the design and manufacturing underpinning these biosensing platforms including biorecognition elements, signal transduction methods, electrode and substrate materials, and fabrication techniques. The applications of these biosensors are then highlighted in detecting a variety of biochemical markers, such as small molecules, hormones, drugs, and macromolecules, in biofluids including interstitial fluid, sweat, wound exudate, saliva, and tears. Additionally, the review also covers recent advances in wearable electrochemical biosensing platforms, such as multi-sensory integration, closed-loop control, and power supply. Furthermore, the challenges associated with critical issues are discussed, such as biocompatibility, biofouling, and sensor degradation, and the opportunities in materials science, nanotechnology, and artificial intelligence to overcome these limitations.}, archive = {J_ADVS}, author = {Haowei Duan and Shuhua Peng and Shuai He and Shi-Yang Tang and Keisuke Goda and Chun H. Wang and Ming Li}, doi = {10.1002/advs.202411433}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411433}, shortjournal = {Adv. Sci.}, title = {Wearable electrochemical biosensors for advanced healthcare monitoring}, volume = {12}, year = {2025}, }
• (2025). A fully integrated orthodontic aligner with force sensing ability for machine learning-assisted diagnosis. ADVS, 12(2), 2411187. (www)

  @article{ , abstract = {Currently, the diagnosis of malocclusion is a highly demanding process involving complicated examinations of the dental occlusion, which increases the demand for innovative tools for occlusal data monitoring. Nevertheless, continuous wireless monitoring within the oral cavity is challenging due to limitations in sampling and device size. In this study, by embedding high-performance piezoelectric sensors into the occlusal surfaces using flexible printed circuits, a fully integrated, flexible, and self-contained transparent aligner is developed. This aligner exhibits excellent sensitivity for occlusal force detection, with a broad detection threshold and continuous pressure monitoring ability at eight distinct sites. Integrated with machine learning algorithm, this fully integrated aligner can also identify and track adverse oral habits that can cause/exacerbate malocclusion, such as lip biting, thumb sucking, and teeth grinding. This system achieved 95% accuracy in determining malocclusion types by analyzing occlusal data from over 1400 malocclusion models. This fully-integrated sensing system, with wireless monitoring and machine learning processing, marks a significant advancement in the development of intraoral wearable sensors. Moreover, it can also facilitate remote orthodontic monitoring and evaluation, offering a new avenue for effective orthodontic care.}, archive = {J_ADVS}, author = {Hao Feng and Wenhao Song and Ruyi Li and Linxin Yang and Xiaoxuan Chen and Jiajun Guo and Xuan Liao and Lei Ni and Zhou Zhu and Junyu Chen and Xibo Pei and Yijun Li and Jian Wang}, doi = {10.1002/advs.202411187}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411187}, shortjournal = {Adv. Sci.}, title = {A fully integrated orthodontic aligner with force sensing ability for machine learning-assisted diagnosis}, volume = {12}, year = {2025}, }
• (2025). Ucp1 ablation improves skeletal muscle glycolytic function in aging mice. ADVS, 12(2), 2411015. (www)

  @article{ , abstract = {Muscular atrophy is among the systematic decline in organ functions in aging, while defective thermogenic fat functionality precedes these anomalies. The potential crosstalk between adipose tissue and muscle during aging is poorly understood. In this study, it is showed that UCP1 knockout (KO) mice characterized deteriorated brown adipose tissue (BAT) function in aging, yet their glucose homeostasis is sustained and energy expenditure is increased, possibly compensated by improved inguinal adipose tissue (iWAT) and muscle functionality compared to age-matched WT mice. To understand the potential crosstalk, RNA-seq and metabolomic analysis were performed on adipose tissue and muscle in aging mice and revealed that creatine levels are increased both in iWAT and muscle of UCP1 KO mice. Interestingly, molecular analysis and metabolite tracing revealed that creatine biosynthesis is increased in iWAT while creatine uptake is increased in muscle in UCP1 KO mice, suggesting creatine transportation from iWAT to muscle. Importantly, creatine analog β-GPA abolished the differences in muscle functions between aging WT and UCP1 KO mice, while UCP1 inhibitor α-CD improved muscle glycolytic function and glucose metabolism in aging mice. Overall, these results suggested that iWAT and skeletal muscle compensate for declined BAT function during aging via creatine metabolism to sustain metabolic homeostasis.}, archive = {J_ADVS}, author = {Jin Qiu and Yuhan Guo and Xiaozhen Guo and Ziqi Liu and Zixuan Li and Jun Zhang and Yutang Cao and Jiaqi Li and Shuwu Yu and Sainan Xu and Juntong Chen and Dongmei Wang and Jian Yu and Mingwei Guo and Wenhao Zhou and Sainan Wang and Yiwen Wang and Xinran Ma and Cen Xie and Lingyan Xu}, doi = {10.1002/advs.202411015}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2411015}, shortjournal = {Adv. Sci.}, title = {Ucp1 ablation improves skeletal muscle glycolytic function in aging mice}, volume = {12}, year = {2025}, }
• (2025). Interfacial engineering of biocompatible nanocapsules for near-infrared-triggered drug release and photothermal therapy. ADVS, 12(2), 2410844. (www)

  @article{ , abstract = {Chemotherapy is an effective option for cancer treatment. However, its clinical application is often limited by the severe side effects of chemical drugs. To overcome these limitations, a novel drug-loaded phase-change nanocapsule system is developed. These nanocapsules are assembled via one-step electrostatic self-assembly through guided interfacial engineering. The phase change material core nanocapsules demonstrate great photothermal-controlled drug release performance and exhibit excellent tumor-targeting drug delivery performance both in vitro and in vivo via the binding of hyaluronic acid shell on the nanocapsule surface with corresponding receptors on the tumor cell membrane. The phototherapy function of the nanocapsules enhances immune activation within the tumor microenvironment, as demonstrated by flow cytometry and multiplex immunohistochemistry. The developed nanocapsules are biocompatible, versatile, and scalable and offer a promising smart delivery platform for controllable near-infrared triggered drug release and photothermal therapy.}, archive = {J_ADVS}, author = {Yuting Xie and Ze Yang and Hang Shen and Jingyi Chen and David A. Weitz and Dong Chen and Jianpeng Sheng and Tingbo Liang}, doi = {10.1002/advs.202410844}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2410844}, shortjournal = {Adv. Sci.}, title = {Interfacial engineering of biocompatible nanocapsules for near-infrared-triggered drug release and photothermal therapy}, volume = {12}, year = {2025}, }
• (2025). Reconstructing the stem leydig cell niche via the testicular extracellular matrix for the treatment of testicular leydig cell dysfunction. ADVS, 12(2), 2410808. (www)

  @article{ , abstract = {Therapies involving the use of stem Leydig cells (SLCs), as testicular mesenchymal stromal cells, have shown great promise in the treatment of Leydig cell (LC) dysfunction in aging males. However, the outcomes of these therapies are not satisfactory. In this study, it is demonstrated that the aging microenvironment of the testicular interstitium impairs the function of SLCs, leading to poor regeneration of LCs and, consequently, inefficient functional restoration. The study develops a decellularized testicular extracellular matrix (dTECM) hydrogel from young pigs and evaluates its safety and feasibility as a supportive niche for the expansion and differentiation of SLCs. dTECM hydrogel facilitates the steroidogenic differentiation of SLCs into LCs, the primary producers of testosterone. The combination of SLCs with a dTECM hydrogel leads to a significant and sustained increase in testosterone levels, which promotes the restoration of spermatogenesis and fertility in an LC-deficient and aged mouse model. Mechanistically, collagen 1 within the dTECM is identified as a key factor contributing to these effects. Notably, symptoms associated with testosterone deficiency syndrome are significantly alleviated in aged mice. These findings may aid the design of therapeutic interventions for patients with testosterone deficiency in the clinic.}, archive = {J_ADVS}, author = {Ani Chi and Chao Yang and Jie Liu and Zhichen Zhai and Xuetao Shi}, doi = {10.1002/advs.202410808}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2410808}, shortjournal = {Adv. Sci.}, title = {Reconstructing the stem leydig cell niche via the testicular extracellular matrix for the treatment of testicular leydig cell dysfunction}, volume = {12}, year = {2025}, }
• (2025). Precise HER2 protein degradation via peptide-conjugated photodynamic therapy for enhanced breast cancer immunotherapy. ADVS, 12(2), 2410778. (www)

  @article{ , abstract = {Breast cancer, the most prevalent malignancy among women, frequently exhibits high HER2 expression, making HER2 a critical therapeutic target. Traditional treatments combining the anti-HER2 antibody trastuzumab with immunotherapy face limitations due to toxicity and tumor microenvironment immunosuppression. This study introduces an innovative strategy combining HER2-targeting peptides with the photosensitizer (PSs) pyropheophorbide-a (Pha) via a gelatinase-cleavable linker, forming self-assembling nanoparticles. These nanoparticles actively target breast cancer cells and generate reactive oxygen species (ROS) under near-infrared light, effectively degrading HER2 proteins. Upon internalization, the linker is cleaved, releasing Pha-PLG and enhancing intracellular photodynamic therapy (PDT). The Pha-PLG molecules self-assemble into nanofibers, prolonging circulation, boosting immune induction, and activating CD8 + T cells, thus promoting a robust anti-tumor immune response. In vivo, studies confirm superior biosafety, tumor targeting, and HER2 degradation, with increased cytotoxic T cell activity and improved antitumor immunity. This integrated strategy offers a promising new avenue for breast cancer treatment.}, archive = {J_ADVS}, author = {Changyong Guo and Fei Gao and Guoyuan Wu and Jinqiu Li and Chunquan Sheng and Shipeng He and Honggang Hu}, doi = {10.1002/advs.202410778}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2410778}, shortjournal = {Adv. Sci.}, title = {Precise HER2 protein degradation via peptide-conjugated photodynamic therapy for enhanced breast cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Synthesis of closely-contacted Cu2O-CoWO4 nanosheet composites for cuproptosis therapy to tumors with sonodynamic and photothermal assistance. ADVS, 12(2), 2410621. (www)

  @article{ , abstract = {Cuproptosis offers a promising and selective therapeutic strategy for cancer therapy. To fully realize its potential, the development of novel cuproptosis therapeutic agents and the achievement of efficient copper release are critical steps forward. Herein, closely-contacted Cu 2 O-CoWO 4 nanosheet heterojunctions (CCW-NH) are successfully synthesized using an in-situ process for cuproptosis therapy. The efficient release of copper ions from CCW-NH can be triggered by ultrasound irradiation, primarily due to the generation of superoxide radicals as the sonodynamic agents via the Z-scheme charge transfer mechanism. When subjected to the combined effects of ultrasound and laser irradiation, the effective release of copper ions is increased by 1.7 times compared to the untreated group, significantly enhancing the efficiency of cuproptosis. And the incorporation of CCW-NH and L-arginine into the temperature-sensitive injectable hydrogel (HP-CCW@LA) ultimately achieved a tumor inhibition rate of up to 95.1%. L-arginine, serving as a reducing agent, enabled the sustained release of highly active Cu + during treatment. Notably, after treating tumors with HP-CCW@LA, the tumor microenvironment is leveraged to promote copper ion conversion, which offers the potential for monitoring tumor therapy efficacy through magnetic resonance imaging. This work offers a novel integrated strategy for the development of new cuproptosis agents and therapeutic evaluation.}, archive = {J_ADVS}, author = {Zhuoran Yang and Zhuo Li and Chunyu Yang and Li Meng and Wei Guo and Liqiang Jing}, doi = {10.1002/advs.202410621}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2410621}, shortjournal = {Adv. Sci.}, title = {Synthesis of closely-contacted Cu2O-CoWO4 nanosheet composites for cuproptosis therapy to tumors with sonodynamic and photothermal assistance}, volume = {12}, year = {2025}, }
• (2025). Biomimetic targeted co-delivery system engineered from genomic insights for precision treatment of osteosarcoma. ADVS, 12(2), 2410427. (www)

  @article{ , abstract = {The high heterogeneity and severe side effects of chemotherapy are major factors contributing to the failure of osteosarcoma treatment. Herein, a comprehensive genomic analysis is conducted, and identified two prominent characteristics of osteosarcoma: significant cyclin-dependent kinases 4 (CDK4) amplification and homologous recombination repair deficiency. Based on these findings, a co-delivery system loaded with CDK4/6 inhibitors and poly ADP-ribose polymerase (PARP) inhibitors is designed. By employing metal–organic frameworks (MOFs) as carriers, issue of drug insolubility is effectively addressed, while also enabling controlled release in response to the tumor microenvironment. To enhance targeting capability and biocompatibility, the MOFs are further coated with a bio-membrane targeting B7H3. This targeted biomimetic co-delivery system possesses several key features: 1) it can precisely target osteosarcoma with high B7H3 expression; 2) the combination of CDK4/6 inhibitors and PARP inhibitors exhibits synergistic effects, significantly impairing tumor's DNA repair capacity; and 3) the system has the potential for combination with photodynamic therapy, amplifying DNA repair defects to maximize tumor cell eradication. Furthermore, it is observed that this co-delivery system can activate immune microenvironment, increasing CD8 + T cell infiltration and converting osteosarcoma from an immune-cold to an immune-hot tumor. In summary, the co-delivery system is an effective therapeutic strategy and holds promise as a novel approach for osteosarcoma treatment.}, archive = {J_ADVS}, author = {Tianqi Luo and Zhijin Fan and Anyu Zeng and Anqi Wang and Yuanwei Pan and Yanyang Xu and Hongmin Chen and Weiqing Chen and Dingmeng Nie and Jiaming Lin and Anfei Huang and Ming Gong and Yufeng Huang and Yun Ding and Xiaojun Zhu and Lang Rao and Jin Wang}, doi = {10.1002/advs.202410427}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2410427}, shortjournal = {Adv. Sci.}, title = {Biomimetic targeted co-delivery system engineered from genomic insights for precision treatment of osteosarcoma}, volume = {12}, year = {2025}, }
• (2025). Intrinsic PD-l1 degradation induced by a novel self-assembling hexapeptide for enhanced cancer immunotherapy. ADVS, 12(2), 2410145. (www)

  @article{ , abstract = {Programmed death-ligand 1 (PD-L1) is a critical immune checkpoint protein that facilitates tumor immune evasion. While antibody-based PD-1/PD-L1 inhibitors have shown promise, their limitations necessitate the development of alternative therapeutic strategies. This work addresses these challenges by developing a hexapeptide, KFM (Lys-Phe-Met-Phe-Met-Lys), capable of both directly downregulating PD-L1 and self-assembling into a ROS-responsive supramolecular hydrogel. This dual functionality allows Gel KFM to function as a localized drug delivery system and a PD-L1 inhibitor. Loading the hydrogel with mitoxantrone (MTX) and metformin (MET) further enhances the therapeutic effect by combining chemotherapy with PD-L1 downregulation. In vitro and in vivo studies demonstrate significant tumor growth inhibition, increased CD8+ T cell infiltration, and reduced intratumoral PD-L1 expression following peritumoral administration. Mechanistically, KFM promotes PD-L1 degradation via a ubiquitin-dependent pathway. This “carrier-free” delivery system expands the role of supramolecular hydrogels beyond passive carriers to active immunotherapeutic agents, offering a promising new strategy for cancer therapy.}, archive = {J_ADVS}, author = {Hongxia Zhang and Ming Ji and Yamei Wang and Mengmeng Jiang and Zongyu Lv and Gongyu Li and Lulu Wang and Zhen Zheng}, doi = {10.1002/advs.202410145}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2410145}, shortjournal = {Adv. Sci.}, title = {Intrinsic PD-l1 degradation induced by a novel self-assembling hexapeptide for enhanced cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Digital quantitative detection for heterogeneous protein and mRNA expression patterns in circulating tumor cells. ADVS, 12(2), 2410120. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) circulating tumor cells (CTCs) exhibit significant phenotypic heterogeneity and diverse gene expression profiles due to epithelial-mesenchymal transition (EMT). However, current detection methods lack the capacity for simultaneous quantification of multidimensional biomarkers, impeding a comprehensive understanding of tumor biology and dynamic changes. Here, the CTC Digital Simultaneous Cross-dimensional Output and Unified Tracking (d-SCOUT) technology is introduced, which enables simultaneous quantification and detailed interpretation of HCC transcriptional and phenotypic biomarkers. Based on self-developed multi-real-time digital PCR (MRT-dPCR) and algorithms, d-SCOUT allows for the unified quantification of Asialoglycoprotein Receptor (ASGPR), Glypican-3 (GPC-3), and Epithelial Cell Adhesion Molecule (EpCAM) proteins, as well as Programmed Death Ligand 1 (PD-L1), GPC-3, and EpCAM mRNA in HCC CTCs, with good sensitivity (LOD of 3.2 CTCs per mL of blood) and reproducibility (mean %CV = 1.80–6.05%). In a study of 99 clinical samples, molecular signatures derived from HCC CTCs demonstrated strong diagnostic potential (AUC = 0.950, sensitivity = 90.6%, specificity = 87.5%). Importantly, by integrating machine learning, d-SCOUT allows clustering of CTC characteristics at the mRNA and protein levels, mapping normalized heterogeneous 2D molecular profiles to assess HCC metastatic risk. Dynamic digital tracking of eight HCC patients undergoing different treatments visually illustrated the therapeutic effects, validating this technology's capability to quantify the treatment efficacy. CTC d-SCOUT enhances understanding of tumor biology and HCC management.}, archive = {J_ADVS}, author = {Hao Li and Jinze Li and Zhiqi Zhang and Qi Yang and Hong Du and Qiongzhu Dong and Zhen Guo and Jia Yao and Shuli Li and Dongshu Li and Nannan Pang and Chuanyu Li and Wei Zhang and Lianqun Zhou}, doi = {10.1002/advs.202410120}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2410120}, shortjournal = {Adv. Sci.}, title = {Digital quantitative detection for heterogeneous protein and mRNA expression patterns in circulating tumor cells}, volume = {12}, year = {2025}, }
• (2025). Self-boosting programmable release of multiple therapeutic agents by activatable heterodimeric prodrug-enzyme assembly for antitumor therapy. ADVS, 12(2), 2409960. (www)

  @article{ , abstract = {Endogenous stimuli-responsive prodrugs, due to their disease lesion specificity and reduced systemic toxicity, have been widely explored for antitumor therapy. However, reactive oxygen species (ROS) as classical endogenous stimuli in the tumor microenvironment (TME) are not enough to achieve the expected drug release. Herein, a ROS-activatable heterodimeric prodrug-loaded enzyme assembly is developed for self-boosting programmable release of multiple therapeutic agents. The heterodimeric prodrug NBS-TK-PTX (namely NTP) is composed of 5-(ethylamino)-9-diethylaminobenzo[ a ]phenothiazinium chloride analog (NBS), paclitaxel (PTX) and ROS-responsive thioketal (TK) linker, which shows a strong binding affinity with glucose oxidase (GOx), thus obtaining NTP@GOx assembly. Notably, the enzymatic activity of GOx in NTP@GOx is inhibited by NTP. The programmable release is achieved by following steps: i) NTP@GOx is partially dissociated in acidic TME, thus releasing a small segment of NTP and GOx. Thereupon, the enzymatic activity of GOx is recovered; ii) GOx-triggered pH reduction further facilitates the dissociation of NTP@GOx, thus accelerating a large amount of NTP and GOx release; iii) The TK linker of prodrug NTP is cleaved by hydrogen peroxide generated by GOx catalysis, thus expediting the release of NBS for Type-I photodynamic therapy and PTX for chemotherapy, respectively. The NTP@GOx shows great potential for multimodal synergistic cancer therapy.}, archive = {J_ADVS}, author = {Shanshan Jiang and Bhaskar Gurram and Junfei Zhu and Shan Lei and Yifan Zhang and Ting He and Oya Tagit and Hui Fang and Peng Huang and Jing Lin}, doi = {10.1002/advs.202409960}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409960}, shortjournal = {Adv. Sci.}, title = {Self-boosting programmable release of multiple therapeutic agents by activatable heterodimeric prodrug-enzyme assembly for antitumor therapy}, volume = {12}, year = {2025}, }
• (2025). Donor–Acceptor viologens with through-space conjugation for enhanced visible-light-driven photocatalysis. ADVS, 12(2), 2409925. (www)

  @article{ , abstract = {A series of novel donor–acceptor (D–A) type viologens with through-space conjugation (TSC) are synthesized. The synergistic effect of D–A conjugation and TSC endow these compounds with a narrower energy gap, excellent redox properties, strong absorption in the visible range (up to 450 nm), and high efficiency of intramolecular charge transfer (ICT). These compounds also exhibit a long-lived charge separation state and stable radical formation. Considering their impressive photophysical and redox properties, TSC viologens with D–A conjugation are explored for visible-light-driven photocatalysis. As a catalyst in oxidative coupling reactions under visible light, compound 9 can achieve a yield of 94%, attributed to its strong ICT effect. Additionally, hybridized into graphitic carbon nitride (g-C₃N₄), compound 9 enhances hydrogen production performance under visible light, achieving an H 2 generation rate of 4102 µmol h −1 g −1 . This study highlights the potential applications of TSC viologens in photocatalytic systems.}, archive = {J_ADVS}, author = {Yi Qiao and Liang Xu and Xiaoyang Liu and Yujing Gao and Naiyao Li and Yawen Li and Tianle Cao and Ni Yan and Zishun Liu and Gang He}, doi = {10.1002/advs.202409925}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409925}, shortjournal = {Adv. Sci.}, title = {Donor–Acceptor viologens with through-space conjugation for enhanced visible-light-driven photocatalysis}, volume = {12}, year = {2025}, }
• (2025). Efficient predictor for immunotherapy efficacy: Detecting pan-clones effector tumor antigen-specific t cells in blood by nanoparticles loading whole tumor antigens. ADVS, 12(2), 2409913. (www)

  @article{ , abstract = {Cancer involves tumor cells and tumor-specific immunity. The ability to accurately quantify tumor-specific immunity is limited. Most immunotherapies function by activating new effector tumor antigen-specific T cells (ETASTs) or reactivating the pre-existing ETASTs repertoire. Therefore, the amount of ETASTs can be used to characterize immunotherapy efficacy. Tumor antigens are highly heterogeneous and detecting most ETASTs is challenging. Therefore, nanoparticles loading whole-cell tumor antigens are used to activate and detect pan-clones ETASTs in the blood. The differences between ETASTs and other T cells are transformed into activated and non-activated states. By measuring markers of the activated status and cytotoxic function of ETASTs, it can distinguish ETASTs from other T cells. ETASTs in patients with lung cancer are higher than those in healthy individuals and those with benign pulmonary nodules. Therapeutic efficacy positively correlated with the number of ETASTs in the blood. ETATS levels increase only in the blood of patients who respond to immunotherapy. Single-cell sequencing studies validated these findings. This study provides a highly accurate, specific, non-invasive, and efficient biomarker for predicting immunotherapy efficacy in lung and other cancers. This method can also be applied to evaluate the efficacy of other treatments, such as radiotherapy, oncolytic viruses, and nanomedicine-based therapies.}, archive = {J_ADVS}, author = {Weibiao Zeng and Jin Wang and Zhike Chen and Jian Yang and Ao Zhu and Yan Zheng and Xianlan Chen and Yuhan Liu and Leilei Wu and Yufeng Xie and Sheng Ju and Jun Chen and Cheng Ding and Chang Li and Xin Tong and Mi Liu and Jun Zhao}, doi = {10.1002/advs.202409913}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409913}, shortjournal = {Adv. Sci.}, title = {Efficient predictor for immunotherapy efficacy: Detecting pan-clones effector tumor antigen-specific t cells in blood by nanoparticles loading whole tumor antigens}, volume = {12}, year = {2025}, }
• (2025). Unraveling the role of the tumor extracellular matrix to inform nanoparticle design for nanomedicine. ADVS, 12(2), 2409898. (www)

  @article{ , abstract = {The extracellular matrix (ECM)—and its mechanobiology—regulates key cellular functions that drive tumor growth and development. Accordingly, mechanotherapy is emerging as an effective approach to treat fibrotic diseases such as cancer. Through restoring the ECM to healthy-like conditions, this treatment aims to improve tissue perfusion, facilitating the delivery of chemotherapies. In particular, the manipulation of ECM is gaining interest as a valuable strategy for developing innovative treatments based on nanoparticles (NPs). However, further progress is required; for instance, it is known that the presence of a dense ECM, which hampers the penetration of NPs, primarily impacts the efficacy of nanomedicines. Furthermore, most 2D in vitro studies fail to recapitulate the physiological deposition of matrix components. To address these issues, a comprehensive understanding of the interactions between the ECM and NPs is needed. This review focuses on the main features of the ECM and its complex interplay with NPs. Recent advances in mechanotherapy are discussed and insights are offered into how its combination with nanomedicine can help improve nanomaterials design and advance their clinical translation.}, archive = {J_ADVS}, author = {Marco Cassani and Soraia Fernandes and Stefania Pagliari and Francesca Cavalieri and Frank Caruso and Giancarlo Forte}, doi = {10.1002/advs.202409898}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409898}, shortjournal = {Adv. Sci.}, title = {Unraveling the role of the tumor extracellular matrix to inform nanoparticle design for nanomedicine}, volume = {12}, year = {2025}, }
• (2025). A single-cell atlas of crab ovary provides new insights into oogenesis in crustaceans. ADVS, 12(2), 2409688. (www)

  @article{ , abstract = {Oogenesis is crucial for sexual reproduction and provides the material basis for population continuation. Nonetheless, the identity of the cells involved, the nature of transformation, and underlying regulators of oogenesis in crustaceans remain elusive. Here, an atlas of the ovary is plotted via single-nuclei RNA sequencing (snRNA-seq) in the mud crab Scylla paramamosain , resulting in five cell types, including germ cells, somatic cells, and three follicle cell types identified, which in turn provides abundant candidate markers for them. Moreover, profiles of ligand-receptor in different cells of the crab ovary indicate the roles of cell communication in oogenesis. Dozens of transcription factors in the trajectory from oogonia to oocytes as well as the key molecules/pathways in somatic cells and follicle cells relevant to oogenesis are screened, which is evolutionarily conserved and its underlying regulatory mechanism is subject to some modification across various phyla. The spatiotemporal expression patterns of seven markers are further verified and the RNAi confirms the essential roles of piwi and VgR in oogenesis. These data help to elucidate the mechanism underlying gametogenesis and the evolution of reproductive strategy in invertebrates.}, archive = {J_ADVS}, author = {Li Lu and Tao Wang and An Liu and Haihui Ye}, doi = {10.1002/advs.202409688}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409688}, shortjournal = {Adv. Sci.}, title = {A single-cell atlas of crab ovary provides new insights into oogenesis in crustaceans}, volume = {12}, year = {2025}, }
• (2025). Sox6 and ALDH1A1 truncation by asparagine endopeptidase defines selective neuronal vulnerability in parkinson's disease. ADVS, 12(2), 2409477. (www)

  @article{ , abstract = {Dopaminergic neurons in the substantia nigra pars compacta (SNpc) demonstrate regionally selective susceptibility in Parkinson's disease (PD) compared to those in the ventral tegmental area (VTA). However, the molecular mechanism for this distinct vulnerability remains unclear. Here, it is shown that Legumain, also known as asparagine endopeptidase (AEP), is activated in a subgroup of SRY-box transcription factor 6 /Aldehyde dehydrogenase 1 family member A1, (Sox6 + /ALDH1A1 + ) neurons in the ventral tier of the SNpc and cleaves Sox6 and ALDH1A1, leading to repression of Special AT-rich sequence binding protein 1 (Satb1) that is a dimeric/tetrameric transcription factor specifically binding to AT-rich DNA sequences, and toxic dopamine metabolite accumulation. AEP cuts Sox6 and ALDH1A1 in dopaminergic neurons that project to the locus coeruleus (LC), abolishing Sox6's transcriptive and ALDH1A1's enzymatic activities. Co-expressing AEP-truncated Sox6 and ALDH1A1 fragments in 3-month-old A53T SNCA transgenic mice accelerates dopamine degeneration, whereas expressing AEP-resistant Sox6 N336A/N446A and ALDH1A1 N220A mutants alleviates rotenone-induced PD pathologies. Hence, different circuitries and intrinsic properties of dopaminergic neurons in the SNpc and VTA render differential predispositions in PD.}, archive = {J_ADVS}, author = {Shuke Nie and Bowei Li and Mengmeng Wang and Zijun Chen and Jiayan Ren and Zixuan Li and Xinli Xu and Zhengjiang Qian and Zhongyun Xie and Jianxin Han and Zhentao Zhang and Zhaohui Zhang and Yingjie Zhu and Zuxin Chen and Xifei Yang and Keqiang Ye}, doi = {10.1002/advs.202409477}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409477}, shortjournal = {Adv. Sci.}, title = {Sox6 and ALDH1A1 truncation by asparagine endopeptidase defines selective neuronal vulnerability in parkinson's disease}, volume = {12}, year = {2025}, }
• (2025). Dual-modal sensing skin adaptive to daylight, darkness, and ultraviolet light for simultaneous full-field deformation measurement and mechanoluminescence responses. ADVS, 12(2), 2409384. (www)

  @article{ , abstract = {Mechanoluminescence (ML) and digital image correlation (DIC) have emerged as promising optical methods to visualize and measure deformation fields. In this study, a dual-modal sensing skin, called the ML-DIC skin is introduced, that is capable of emitting ML and facilitating DIC measurements under various lighting conditions, including daylight, night or darkness, and UV irradiation. Four ML-DIC skins are fabricated with or without carbon nanotubes (CNTs) using a composite powder consisting of SrAl2O4: Eu,Dy (SAO), and acrylic resin, with CNT milling times of 48, 72, and 96 h for three of four skins, respectively. DIC measurements are performed under multiple lighting conditions for measuring photoluminescence, persistence luminescence, and reflection. Uniaxial tension tests demonstrate the superior performance of ML-DIC skins with CNTs compared with pristine SAO skins, with the skin subjected to 48 h of CNT dispersion exhibiting optimal performance. Further investigations focus on ML emission and DIC measurements near the crack-tip vicinity of static and propagating cracks as well as on surfaces above subsurface cracks. The integration of ML and DIC techniques offers a versatile approach for comprehensive deformation analysis applicable to diverse environments, with implications for materials science, engineering, and structural health monitoring.}, archive = {J_ADVS}, author = {Suman Timilsina and Cheol Woo Jo and Kwang Ho Lee and Kee-Sun Sohn and Ji Sik Kim}, doi = {10.1002/advs.202409384}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409384}, shortjournal = {Adv. Sci.}, title = {Dual-modal sensing skin adaptive to daylight, darkness, and ultraviolet light for simultaneous full-field deformation measurement and mechanoluminescence responses}, volume = {12}, year = {2025}, }
• (2025). Enantioselective assembly of fully substituted α-amino allenoates through a mannich addition and stepwise [3,3]-σ rearrangement sequence. ADVS, 12(2), 2409334. (www)

  @article{ , abstract = {Chiral fully-substituted allenes are synthetically significant and pivotal building blocks that can engage in diverse transformations toward a variety of bioactive molecules. The enantioselective assembly of these skeletons using readily available reactants offers significant advantages but remains challenging. Herein, an asymmetric formal Michael-type addition of alkynyl imines with the key alkylgold intermediates derived in situ from N -propargylamides is accomplished under gold-complex and chiral quinine-derived squaramide (QN-SQA) synergetic catalysis. Control experiments and the density functional theory (DFT) calculations indicated that this cascade reaction involves a Mannich-type addition and stepwise [3,3]-σ rearrangement sequence, leading to the fully substituted α-amino allenoates, which are elusive and take multi-step to prepare with other methods, in high yields and excellent enantioselectivity.}, archive = {J_ADVS}, author = {Haoxuan Yuan and Yi Zhou and Xiongda Xie and Ming Bao and Kewei Chen and Kemiao Hong and Zhixiang Yu and Xinfang Xu}, doi = {10.1002/advs.202409334}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409334}, shortjournal = {Adv. Sci.}, title = {Enantioselective assembly of fully substituted α-amino allenoates through a mannich addition and stepwise [3,3]-σ rearrangement sequence}, volume = {12}, year = {2025}, }
• (2025). Advances in metal halide perovskite memristors: A review from a co-design perspective. ADVS, 12(2), 2409291. (www)

  @article{ , abstract = {The memristor has recently demonstrated considerable potential in the field of large-scale data information processing. Metal halide perovskites (MHPs) have emerged as the leading contenders for memristors due to their sensitive optoelectronic response, low power consumption, and ability to be prepared at low temperatures. This work presents a comprehensive enumeration and analysis of the predominant research advancements in mechanisms of resistance switch (RS) behaviors in MHPs-based memristors, along with a summary of useful characterization techniques. The impact of diverse optimization techniques on the functionality of perovskite memristors is examined and synthesized. Additionally, the potential of MHPs memristors in data processing, physical encryption devices, artificial synapses, and brain-like computing advancement of MHPs memristors is evaluated. This review can prove a valuable reference point for the future development of perovskite memristors applications. In conclusion, the current challenges and prospects of MHPs-based memristors are discussed in order to provide insights into potential avenues for the development of next-generation information storage technologies and biomimetic applications.}, archive = {J_ADVS}, author = {Bowen Jiang and Xiang Chen and Xiaoxin Pan and Li Tao and Yuangqiang Huang and Jiahao Tang and Xiaoqing Li and Peixiong Wang and Guokun Ma and Jun Zhang and Hao Wang}, doi = {10.1002/advs.202409291}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409291}, shortjournal = {Adv. Sci.}, title = {Advances in metal halide perovskite memristors: A review from a co-design perspective}, volume = {12}, year = {2025}, }
• (2025). 1,8-diazabicyclo[5.4.0]undec-7-ene as cyclic ether electrolyte polymerization inhibition for wide-temperature-range high-rate lithium-ion batteries. ADVS, 12(2), 2409259. (www)

  @article{ , abstract = {1,3-Dioxolane (DOL), with its broad liquid phase temperature window and low Li + -solvent binding energy, stands out as an ideal solvent candidate for the wide-temperature and high-rate electrolytes. Unfortunately, DOL is susceptible to undergo ring-opening polymerization under common lithium salts, which markedly retards the reaction kinetics. This work introduces the organic basic additive 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) to effectively suppress the polymerization, thus achieving compatibility between LiFSI, LiDFOB lithium salts, and DOL. Furthermore, density functional theory (DFT) calculations are utilized to elucidate the underlying mechanisms of DOL polymerization and to clarify how DBU inhibits its polymerization. The resulting electrolyte, devoid of polymer chain formation, forms a weak solvation structure rich in anions, which demonstrates rapid ion transport kinetics in the bulk electrolyte and excellent electrochemical stability at the electrolyte–electrode interfaces (EEIs) simultaneously. When applied to the LiFePO 4 ||graphite full cell, it exhibits exceptional wide-temperature and high-rate performance, with specific capacities reaching 101.2 mAh g −1 at room temperature (20 C), 36.9 mAh g −1 at −40 °C (0.5 C), and 118.0 mAh g −1 at 60 °C (20 C). This study significantly guides the development of wide-temperature, high-rate electrolytes.}, archive = {J_ADVS}, author = {Hui Tian and Zixin Hong and Zhenhan Fang and Yufeng Luo and Hengcai Wu and Fei Zhao and Qunqing Li and Shoushan Fan and Jiaping Wang}, doi = {10.1002/advs.202409259}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409259}, shortjournal = {Adv. Sci.}, title = {1,8-diazabicyclo[5.4.0]undec-7-ene as cyclic ether electrolyte polymerization inhibition for wide-temperature-range high-rate lithium-ion batteries}, volume = {12}, year = {2025}, }
• (2025). Harnessing tumor cell-derived exosomes for immune rejection management in corneal transplantation. ADVS, 12(2), 2409207. (www)

  @article{ , abstract = {Transplantation remains the definitive treatment for end-stage organ failures, but its efficacy is frequently compromised by immune rejection. This study introduces a novel strategy by utilizing tumor-derived exosomes from B16-F10 melanoma cells (B16-Exo), diverging from the conventional use of immune cell-derived exosomes, to alleviate post-transplantation immune rejection. Utilizing murine corneal transplantation as a model, it is demonstrated that B16-Exo significantly reduces immune rejection, evidenced by decreased corneal opacity, neovascularization, and immune dysregulation, while enhancing postoperative survival. Proteomic analyses reveal differential expression of pivotal proteins in B16-Exo, notably the JAK2 protein within the JAK-STAT signaling pathway, which has been mechanistically demonstrated to amplify the activity of myeloid-derived suppressor cells (MDSCs) and inhibit T cell proliferation. These findings demonstrate the significant immunomodulatory effect of B16-Exo in transplant immunology, supporting the continued exploration of tumor-derived exosomes as a platform to uncover novel immunosuppressive mechanisms in transplantation.}, archive = {J_ADVS}, author = {Jieru Yang and Huanmin Kang and Yingyi Liu and Shan Lu and Huihui Wu and Bikui Zhang and Yan He and Wenhu Zhou}, doi = {10.1002/advs.202409207}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2409207}, shortjournal = {Adv. Sci.}, title = {Harnessing tumor cell-derived exosomes for immune rejection management in corneal transplantation}, volume = {12}, year = {2025}, }
• (2025). Colorimetric thermography by a long-infrared dual-band metalens. ADVS, 12(2), 2408683. (www)

  @article{ , abstract = {Infrared (IR) radiation thermography is extensively utilized in diverse fields due to its non-contact capability. Nevertheless, its effectiveness is often compromised by the significant emissivity variations among different objects, limiting its application to specific setups or focused object types. Colorimetric thermography is introduced as an alternative emissivity-independent method of radiation thermometry. This technique involves measuring radiance across two or more spectral bands and calculating the object's temperature based on the signal ratio, thereby mitigating emissivity effects under certain conditions. However, this method has the trade-off of necessitating bulky optical systems, complex filter imaging configurations, and sensor structures. To meet the requirements of IR thermography for compact structure, lightweight design, and customizability, a dual-band metalens is developed for the IR colorimetric thermography. The central wavelengths targeted are 9.5 and 12.5 µm. The dual-band IR imaging by the fabricated dual-band metalens is demonstrated, and the colorimetric thermography of low-emissivity objects is performed without presetting emissivity values. This approach significantly eliminates measurement errors associated with emissivity by an average of 50.16% across a temperature range of 60–180 °C. This innovation paves the way for dynamic and multi-target thermography using compact IR systems in complex environments.}, archive = {J_ADVS}, author = {Zhendong Luo and Peng Zhang and Huwang Hou and Yiming Li and Binzhao Li and Yanji Yi and Lianjie Xu and Ting Meng and Zihan Geng and Mu Ku Chen and Yang Zhao}, doi = {10.1002/advs.202408683}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408683}, shortjournal = {Adv. Sci.}, title = {Colorimetric thermography by a long-infrared dual-band metalens}, volume = {12}, year = {2025}, }
• (2025). Targeted sonodynamic therapy platform for holistic integrative helicobacter pylori therapy. ADVS, 12(2), 2408583. (www)

  @article{ , abstract = {Helicobacter pylori ( H. pylori ) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along with the adverse effects caused by complicated medication protocols, has made the eradication of H. pylori a more formidable challenge, necessitating alternative therapeutics. Herein, a targeted nanoplatform is reported based on sonodynamic therapy, the chitosan-conjugated fucose loaded with indocyanine green (ICG@FCS). It penetrates the gastric mucosa and homes in on H. pylori through dual targeting mechanisms: molecular via fucose and physical via ultrasound. Upon ultrasound activation, it generates singlet oxygen, effectively attacking planktonic bacteria, disrupting biofilms, and facilitating the clearance of intracellular bacteria by promoting autophagy, including multidrug-resistant strains. The ICG@FCS nanoplatform minimally affects the gut microbiota and aids in gastric mucosa repair. a holistic integrative H. pylori therapy strategy is proposed that targets eradication while preserving gastrointestinal health. This strategy emphasizes the importance of maintaining patient health while eradicating the pathogen. This advancement is set to refine the comprehensive antibacterial approach, offering a promising horizon in the ongoing battle against antibiotic resistance and more effective gastric cancer prevention strategies.}, archive = {J_ADVS}, author = {Xiaojing Yin and Yongkang Lai and Xinyuan Zhang and Tingling Zhang and Jing Tian and Yiqi Du and Zhaoshen Li and Jie Gao}, doi = {10.1002/advs.202408583}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408583}, shortjournal = {Adv. Sci.}, title = {Targeted sonodynamic therapy platform for holistic integrative helicobacter pylori therapy}, volume = {12}, year = {2025}, }
• (2025). N6-methyladenosine regulates cilia elongation in cancer cells by modulating HDAC6 expression. ADVS, 12(2), 2408488. (www)

  @article{ , abstract = {Primary cilia are microtubule-based organelles that function as cellular antennae to address multiple metabolic and extracellular cues. The past decade has seen significant advances in understanding the pro-tumorigenic role of N 6 -methyladenosine (m 6 A) modification in tumorigenesis. Nevertheless, whether m 6 A modification modulates the cilia dynamics during cancer progression remains unclear. Here, the results show that m 6 A methyltransferase METTL3 regulates cilia length in cancer cells via HDAC6-dependent deacetylation of axonemal α-tubulin, thereby controlling cancer development. Mechanically, METTL3 positively regulates the translation of HDAC6 in an m 6 A-dependent manner, while m 6 A methylation of A3678 in the coding sequence (CDS) of HDAC6 ameliorates its translation efficiency via facilitating the binding with YTHDF3. The upregulation of HDAC6 induced by METTL3 over-expression is capable of inhibiting cilia elongation and acetylation of α-tubulin, thereby shortening cilia length and accelerating the progression of cervical cancer both in vitro and in vivo. Collectively, depletion of METTL3-mediated m 6 A modification leads to abnormally elongated cilia via suppressing HDAC6-dependent deacetylation of axonemal α-tubulin, ultimately attenuating cell growth and cervical cancer development.}, archive = {J_ADVS}, author = {Yalan Rui and Haisheng Zhang and Kangning Yu and Shiyao Qiao and Chenglin Gao and Xiansong Wang and Weifeng Yang and Gholamreza Asadikaram and Zigang Li and Kun Zhang and Jianxin Peng and Jiexin Li and Junming He and Hongsheng Wang}, doi = {10.1002/advs.202408488}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408488}, shortjournal = {Adv. Sci.}, title = {N6-methyladenosine regulates cilia elongation in cancer cells by modulating HDAC6 expression}, volume = {12}, year = {2025}, }
• (2025). Non-hermitian global synchronization. ADVS, 12(2), 2408460. (www)

  @article{ , abstract = {Synchronization of coupled nonlinear oscillators is a prevalent phenomenon in natural systems and can play important roles in various fields of modern science, such as laser arrays and electric networks. However, achieving robust global synchronization has always been a significant challenge due to its extreme susceptibility to initial conditions and structural perturbations. Here, a novel approach is presented to achieve robust global synchronization by manipulating the interplay between non-Hermitian physics and nonlinear dynamics. Remarkably, the initial-state-independent non-Hermitian skin and topological global synchronization are proposed, exhibiting diverse anomalous effects such as the enlarged-size triggered non-Hermitian global synchronization and nonlinear skin states-dominated global synchronization. To validate the findings, nonlinear topoelectrical circuits for experimental observation of non-Hermitian global synchronization are designed and fabricated. The work opens up a promising avenue for establishing resilient global synchronization with potential applications in constructing high-radiance laser arrays and topologically synchronized networks.}, archive = {J_ADVS}, author = {Weixuan Zhang and Fengxiao Di and Xiangdong Zhang}, doi = {10.1002/advs.202408460}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408460}, shortjournal = {Adv. Sci.}, title = {Non-hermitian global synchronization}, volume = {12}, year = {2025}, }
• (2025). 3D-printed bioceramic scaffolds reinforced by the in situ oriented growth of grains for supercritical bone defect reconstruction. ADVS, 12(2), 2408459. (www)

  @article{ , abstract = {Porous calcium phosphate ceramics have attracted widespread attention owing to their excellent bioactivity. However, their poor mechanical properties severely limit their clinical applications. Significantly improving the mechanical strength of porous CaP ceramics while maintaining their bioactivity remains a major challenge. To address this issue, calcium sulfate is used to regulate the directional growth of hydroxyapatite grains during ceramic sintering. The in situ oriented grains can not only alleviate the stress concentration but also strengthen the bonding force between the ceramic grain boundaries. Calcium sulfate improves the release of active calcium ions from calcium phosphate ceramics, further enhancing their bioactivity and osteoinductivity in vivo. Transcriptome and proteome sequencing reveals that the in situ whisker-reinforced ceramics increase the expression of proteins related to calcium ion binding and promote the expression of osteogenesis-related proteins. In the supercritical bone defect repair model, repair of the defect is achieved within 3 months, with mechanical recovery reaching more than 70% of the autologous bone.}, archive = {J_ADVS}, author = {Boqing Zhang and Kaixin Wang and Xingyu Gui and Wenzhao Wang and Ping Song and Lina Wu and Likun Guo and Changchun Zhou and Yujiang Fan and Xingdong Zhang}, doi = {10.1002/advs.202408459}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408459}, shortjournal = {Adv. Sci.}, title = {3D-printed bioceramic scaffolds reinforced by the in situ oriented growth of grains for supercritical bone defect reconstruction}, volume = {12}, year = {2025}, }
• (2025). Dual-vibration-assisted charge transport through hexabenzocoronene in single-molecule junctions. ADVS, 12(2), 2408310. (www)

  @article{ , abstract = {Gaining deep understanding and effective regulation of the charge transport mechanism within molecular junctions is essential for the development of electronic devices. In this work, a series of hexabenzocoronene-based single-molecule junctions are successfully constructed, and their temperature-dependent charge transport properties are studied. It is found that rotational vibrations of both benzene and hexabenzocoronene rings are sequentially excited as the temperature increases, and the electron-vibration coupling enhances charge tunneling. In addition, the transition temperature between distinct vibration-assisted tunneling modes and the activation energies show strong correlations with the molecular vibration frequency and molecular length. This study unveils the distinct dual-vibration-assisted molecular tunneling mechanism, significantly enhancing the ability to precisely control molecular charge transport and develop functional molecular devices.}, archive = {J_ADVS}, author = {Miao Zhang and Boyu Wang and Hongxing Jia and Xinmiao Xie and Jie Hao and Li Zhou and Pingwu Du and Jinying Wang and Chuancheng Jia and Xuefeng Guo}, doi = {10.1002/advs.202408310}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408310}, shortjournal = {Adv. Sci.}, title = {Dual-vibration-assisted charge transport through hexabenzocoronene in single-molecule junctions}, volume = {12}, year = {2025}, }
• (2025). Whisker-implanted biomimetic electronic skin for tactile sensing and blind perception. ADVS, 12(2), 2408162. (www)

  @article{ , abstract = {Rodent whiskers are a distinct class of tactile sensors that work in conjunction with the biological skin to discern airstreams and obstacles with remarkable sensitivity, facilitating navigation around proximate objects. In this study, a flexible artificial skin is developed comprising sensory active units, including electronic skin (e-skin) and an artificial whisker, inspired by the sensory capabilities of rodent skin and whiskers. As a novel strategy, unique congruent air pockets are introduced within the e-skin to enhance the sensitivity. Mechanical stimuli applied to the artificial whisker are efficiently transmitted to the active e-skin, which generates a sensitive tactile perception response. The developed artificial skin exhibits high sensitivity, a wide sensing range, high flexibility, superior stability, and tensile strength. The artificial whisker facilitates the sensitive detection of a broad range of applied mechanical forces. Therefore, the artificial skin can sense subtle and vigorous tactile stimuli including airstreams and field obstacles. The ability to sense, discriminate, and decipher the airstreams and obstacles imparts outstanding tactile sensing and blind perception characteristics to the artificial skin. This artificial skin is a promising platform for the development of sensitive e-skins suitable for a broad range of applications, such as human-machine interfaces, robotics, and wearable electronics.}, archive = {J_ADVS}, author = {Mohammad Zarei and An Woo Jeong and Seung Goo Lee}, doi = {10.1002/advs.202408162}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408162}, shortjournal = {Adv. Sci.}, title = {Whisker-implanted biomimetic electronic skin for tactile sensing and blind perception}, volume = {12}, year = {2025}, }
• (2025). High-performance MXene hydrogel for self-propelled marangoni swimmers and water-enabled electricity generator. ADVS, 12(2), 2408161. (www)

  @article{ , abstract = {Developing multifunctional materials that integrate self-propulsion and self-power generation is a significant challenge. This study introduces a high-performance MXene-chitosan composite hydrogel (CM) that successfully combines these functionalities. Utilizing Schiff base bond and hydrogen bond interactions, the CM hydrogel, composed of chitosan, vanillin, and MXene, achieves exceptional self-propulsion on water driven by Marangoni forces. The hydrogel demonstrates rapid movement, extended operation, and controllable trajectories. Notably, the CM hydrogel also exhibits superior degradability, recyclability, and repeatability. Furthermore, the nano-confined channels within the hydrogel play a crucial role in enhancing its water-enabled electricity generation (WEG) performance. By efficiently adsorbing water molecules and selectively transporting cations through these channels, the hydrogel can generate electricity from water molecules and cations more efficiently. As a result, the CM-WEG achieves a stable open-circuit voltage of up to 0.83 V and a short-circuit current of 0.107 mA on seawater, with further improvements in K 2 CO 3 -containing water, reaching 1.26 V and 0.922 mA. Leveraging its unique combination of self-propulsion and WEG functionalities, the CM hydrogel is successfully used for cargo delivery while simultaneously powering electronic devices. This research represents a significant step toward the development of self-powered, autonomous soft robotics, opening new research directions in the field.}, archive = {J_ADVS}, author = {Jiayi Zhou and Yan Zhang and Ming Zhang and Dongye Yang and Wenwei Huang and Ao Zheng and Lingyan Cao}, doi = {10.1002/advs.202408161}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408161}, shortjournal = {Adv. Sci.}, title = {High-performance MXene hydrogel for self-propelled marangoni swimmers and water-enabled electricity generator}, volume = {12}, year = {2025}, }
• (2025). Unveiling the mechanism of deprotonation and proton transfer of DNA polymerase catalysis via single-molecule conductance. ADVS, 12(2), 2408112. (www)

  @article{ , abstract = {DNA polymerases (Pols) play important roles in the transmission of genetic information. Although the function and (de)regulation of Pols are linked to many human diseases, the key mechanism of 3′-OH deprotonation and the PP i formation are not totally clear. In this work, a method is presented to detect the full catalytic cycle of human Pol (hPol β ) in graphene-molecule-graphene single-molecule junctions. Real-time in situ monitoring successfully revealed the spatial and temporal properties of the open and closed conformation states of hPol β , distinguishing the reaction states in the Pols catalytic cycle and unveiling 3′-OH deprotonation and pyrophosphate (PP i ) formation mechanism of hPol β . Proton inventory experiment demonstrated that the rate-limiting step of PP i formation is deprotonation, which occurs before a reverse conformational change. Additionally, by detecting the acidity (p K a ), it is found that Mg A -bound OH − acted as a general base and activated the nucleophile of 3′-OH, and that acidic residue D190 or D192 coordinated with Mg B as a proton donor to PP i . This work provides useful insights into a fundamental chemical reaction that impacts genome synthesis efficiency and Pol fidelity, which the discovery of Pol-targeting drugs and design of artificial Pols for DNA synthetic applications are expected to accelerated.}, archive = {J_ADVS}, author = {Lihua Zhao and Yang Xu and Zhiheng Yang and Wenzhe Liu and Shichao Zhong and Jingwei Bai and Xuefeng Guo}, doi = {10.1002/advs.202408112}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408112}, shortjournal = {Adv. Sci.}, title = {Unveiling the mechanism of deprotonation and proton transfer of DNA polymerase catalysis via single-molecule conductance}, volume = {12}, year = {2025}, }
• (2025). Nanometer-scale 1D negative differential resistance channels in van der waals layers. ADVS, 12(2), 2408090. (www)

  @article{ , abstract = {Negative differential resistance (NDR) is the key feature of resonant tunneling diodes exploited for high-frequency and low-power devices and recent studies have focused on NDR in van der Waals heterostructures and nanoscale materials. Here, strong NDR confined along a 1-nm-wide 1D channel within a van der Waals layer 1T-TaS 2 is reported. Using scanning tunneling microscopy, a double 1D NDR channel formed along the sides of a charge–density-wave domain wall of 1T-TaS 2 is found. The density functional theory calculation elucidates that the strong local band-bending at the domain wall and the interlayer orbital overlap cooperate to bring about 1D NDR channels. Furthermore, the NDR is well controlled by changing the tunneling junction distance. This result would be important for nanoscale device applications based on strong nonlinear resistance within van der Waals material architectures.}, archive = {J_ADVS}, author = {Qirong Yao and Jae Whan Park and Choongjae Won and Sang-Wook Cheong and Han Woong Yeom}, doi = {10.1002/advs.202408090}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408090}, shortjournal = {Adv. Sci.}, title = {Nanometer-scale 1D negative differential resistance channels in van der waals layers}, volume = {12}, year = {2025}, }
• (2025). From images to genes: Radiogenomics based on artificial intelligence to achieve non-invasive precision medicine in cancer patients. ADVS, 12(2), 2408069. (www)

  @article{ , abstract = {With the increasing demand for precision medicine in cancer patients, radiogenomics emerges as a promising frontier. Radiogenomics is originally defined as a methodology for associating gene expression information from high-throughput technologies with imaging phenotypes. However, with advancements in medical imaging, high-throughput omics technologies, and artificial intelligence, both the concept and application of radiogenomics have significantly broadened. In this review, the history of radiogenomics is enumerated, related omics technologies, the five basic workflows and their applications across tumors, the role of AI in radiogenomics, the opportunities and challenges from tumor heterogeneity, and the applications of radiogenomics in tumor immune microenvironment. The application of radiogenomics in positron emission tomography and the role of radiogenomics in multi-omics studies is also discussed. Finally, the challenges faced by clinical transformation, along with future trends in this field is discussed.}, archive = {J_ADVS}, author = {Yusheng Guo and Tianxiang Li and Bingxin Gong and Yan Hu and Sichen Wang and Lian Yang and Chuansheng Zheng}, doi = {10.1002/advs.202408069}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2408069}, shortjournal = {Adv. Sci.}, title = {From images to genes: Radiogenomics based on artificial intelligence to achieve non-invasive precision medicine in cancer patients}, volume = {12}, year = {2025}, }
• (2025). Arrangement free wireless power transfer via strongly coupled electrical resonances. ADVS, 12(2), 2407827. (www)

  @article{ , abstract = {Research on magnetically resonant wireless power transfer (MRWPT) is actively pursued for diverse applications. Dependent on magnetic fields for wireless power transfer (WPT), MRWPT encounters a challenge due to the absence of monopole magnetic properties, impacting power transfer efficiency (PTE) sensitivity to receiver arrangement. Despite extensive research, achieving the desired receiver freedom remains a persistent challenge—a core limitation rooted in magnetic field-based WPT. To address this, electrically resonant wireless power transfer (ERWPT) is proposed, utilizing an open bifilar coil at a resonant frequency. Experimental results demonstrate nonradiative power transfer of up to 50 watts and 46% PTE over a distance of 2 meters, maintaining consistent PTE performance. This phenomenon arises from the electric charge's monopole capability, distinguishing it from the limitations associated with magnetic fields. The practical viability of this system is delved and suggest directions for further investigation. ERWPT overcomes MRWPT challenges, ensuring lateral plane consistent efficiency and offering a breakthrough for practical wireless power applications.}, archive = {J_ADVS}, author = {Bonyoung Lee and Jungho Kim and Hyunkyeong Jo and Hyungki Min and Franklin Bien}, doi = {10.1002/advs.202407827}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407827}, shortjournal = {Adv. Sci.}, title = {Arrangement free wireless power transfer via strongly coupled electrical resonances}, volume = {12}, year = {2025}, }
• (2025). Osteoblast-derived ECM1 promotes anti-androgen resistance in bone metastatic prostate cancer. ADVS, 12(2), 2407662. (www)

  @article{ , abstract = {Acquired resistance to hormonal therapy, particularly enzalutamide (ENZ), remains a significant obstacle in the treatment of advanced bone metastatic prostate cancer. Here, it is demonstrated that under ENZ treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affects surrounding prostate cancer cells, promoting tumor cell proliferation and anti-androgen resistance. Mechanistically, ECM1 interacts with the enolase 1 (ENO1) receptor on the prostate cancer cell membrane, leading to its phosphorylation at the Y189 site. This event further recruits adapter proteins including growth factor receptor-bound protein 2 (GRB2) and son of sevenless homolog 1 (SOS1), which activates the downstream mitogen-activated protein kinase (MAPK) signaling pathway to induce anti-androgen resistance. Furthermore, inhibiting ECM1 or utilizing the ENO1-targeting inhibitor phosphonoacetohydroxamate (PhAH) significantly restores tumor cell sensitivity to ENZ. Taken together, a potential mechanism is identified through which osteoblast-derived ECM1 drives resistance in bone metastatic prostate cancer under ENZ treatment. Additionally, the findings indicate that ECM1 and ENO1 may serve as potential targets for developing therapies for bone metastatic castration-resistant prostate cancer.}, archive = {J_ADVS}, author = {Xinwen Wang and Min Wang and Qijun Lin and Lixin He and Baolin Zhang and Xin Chen and Guanhong Chen and Hong Du and Chuandong Lang and Xinsheng Peng and Yuhu Dai}, doi = {10.1002/advs.202407662}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407662}, shortjournal = {Adv. Sci.}, title = {Osteoblast-derived ECM1 promotes anti-androgen resistance in bone metastatic prostate cancer}, volume = {12}, year = {2025}, }
• (2025). Integrated transcriptome analysis reveals novel molecular signatures for schizophrenia characterization. ADVS, 12(2), 2407628. (www)

  @article{ , abstract = {Schizophrenia (SCZ) is a complex psychiatric disorder presenting challenges for characterization. The current study aimed to identify and evaluate disease-responsive essential genes (DREGs) to enhance the molecular characterization of SCZ. RNA-sequencing data from PsychENCODE (536 SCZ patients, 832 controls) and peripheral blood transcriptome data from 144 recruited subjects (59 SCZ patients, 6 non-SCZ psychiatric patients, 79 controls) are analyzed. Shared differential expression genes are obtained using three algorithms. Support vector machine (SVM)-based recursive feature elimination is employed to identify DREGs. The biological relevance of these DREGs is examined through protein–protein interaction network, pathway enrichment, polygenic scoring, and brain tissue expression. Key DREGs are validated in SCZ animal models. A DREGs-based machine-learning model for SCZ characterization is developed and its performance is assessed using multiple datasets. The analysis identified 184 DREGs forming an interconnected network involved in synaptic plasticity, inflammation, neuronal development, and neurotransmission. DREGs exhibited distinct expression in SCZ-related brain regions and animal models. Their genetic contributions are comparable to genome-wide polygenic risk scores. The DREG-based SVM model demonstrated high performance (AUC 85% for SCZ characterization, 79% for specificity). These findings provide new insights into the molecular mechanisms underlying SCZ and emphasize the potential of DREGs in improving SCZ characterization.}, archive = {J_ADVS}, author = {Tong Ni and Yu Sun and Zefeng Li and Tao Tan and Wei Han and Miao Li and Li Zhu and Jing Xiao and Huiying Wang and Wenpei Zhang and Yitian Ma and Biao Wang and Di Wen and Teng Chen and Justin Tubbs and Xiaofeng Zeng and Jiangwei Yan and Hongsheng Gui and Pak Sham and Fanglin Guan}, doi = {10.1002/advs.202407628}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407628}, shortjournal = {Adv. Sci.}, title = {Integrated transcriptome analysis reveals novel molecular signatures for schizophrenia characterization}, volume = {12}, year = {2025}, }
• (2025). Unconventional anomalous hall effect driven by self-intercalation in covalent 2D magnet Cr2Te3. ADVS, 12(2), 2407625. (www)

  @article{ , abstract = {Covalent 2D magnets such as Cr 2 Te 3 , which feature self-intercalated magnetic cations located between monolayers of transition-metal dichalcogenide material, offer a unique platform for controlling magnetic order and spin texture, enabling new potential applications for spintronic devices. Here, it is demonstrated that the unconventional anomalous Hall effect (AHE) in Cr 2 Te 3 , characterized by additional humps and dips near the coercive field in AHE hysteresis, originates from an intrinsic mechanism dictated by the self-intercalation. This mechanism is distinctly different from previously proposed mechanisms such as topological Hall effect, or two-channel AHE arising from spatial inhomogeneities. Crucially, multiple Weyl-like nodes emerge in the electronic band structure due to strong spin-orbit coupling, whose positions relative to the Fermi level is sensitively modulated by the canting angles of the self-intercalated Cr cations. These nodes contribute strongly to the Berry curvature and AHE conductivity. This component competes with the contribution from bands that are less affected by the self-intercalation, resulting in a sign change in AHE with temperature and the emergence of additional humps and dips. The findings provide compelling evidence for the intrinsic origin of the unconventional AHE in Cr 2 Te 3 and further establish self-intercalation as a control knob for engineering AHE in complex magnets.}, archive = {J_ADVS}, author = {Keke He and Mengying Bian and Samuel D. Seddon and Koushik Jagadish and Andrea Mucchietto and He Ren and Erik Kirstein and Reza Asadi and Jaeil Bai and Chao Yao and Sheng Pan and Jie-Xiang Yu and Peter Milde and Chang Huai and Haolei Hui and Jiadong Zang and Renat Sabirianov and Xuemei M. Cheng and Guoxing Miao and Hui Xing and Yu-Tsun Shao and Scott A. Crooker and Lukas Eng and Yanglong Hou and Jonathan P. Bird and Hao Zeng}, doi = {10.1002/advs.202407625}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407625}, shortjournal = {Adv. Sci.}, title = {Unconventional anomalous hall effect driven by self-intercalation in covalent 2D magnet Cr2Te3}, volume = {12}, year = {2025}, }
• (2025). Engineering the coherent phonon transport in polar ferromagnetic oxide superlattices. ADVS, 12(2), 2407382. (www)

  @article{ , abstract = {Artificial superlattices composed of perovskite oxides serves as an essential platform for engineering coherent phonon transport by redefining the lattice periodicity, which strongly influences the lattice-coupled phase transitions in charge and spin degrees of freedom. However, previous methods of manipulating phonons have been limited to controlling the periodicity of superlattice, rather than utilizing complex mutual interactions that are prominent in transition metal oxides. In this study on oxide superlattices composed of ferromagnetic metallic SrRuO 3 and quantum paraelectric SrTiO 3 , phonon modulation by controlling the geometry of superlattice in atomic-scale precision is realized, demonstrating the coherent phonon engineering using structural and magnetic phase transitions. By modulating the interface density, coherent-incoherent crossover of the phonon transport at room temperature is observed, which is coupled with a change in interfacial structural continuity. Upon cooling, the close relation between phonon transport and multiple phase transitions is identified. In particular, the enhancement of the polar state in SrTiO 3 layer at ≈200 K leads to the weakening of phonon coherence and a further reduction of thermal conductivity in superlattices compared to the bulk limit. These findings provide a guide to developing future thermoelectric nanodevices by engineering the coherence of phonons via the design of complex oxide heterostructures.}, archive = {J_ADVS}, author = {In Hyeok Choi and Seung Gyo Jeong and Do-Gyeom Jeong and Ambrose Seo and Woo Seok Choi and Jong Seok Lee}, doi = {10.1002/advs.202407382}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407382}, shortjournal = {Adv. Sci.}, title = {Engineering the coherent phonon transport in polar ferromagnetic oxide superlattices}, volume = {12}, year = {2025}, }
• (2025). Sustained endocytosis inhibition via locally-injected drug-eluting hydrogel improves ADCC-mediated antibody therapy in colorectal cancer. ADVS, 12(2), 2407239. (www)

  @article{ , abstract = {The epidermal growth factor receptor (EGFR) is a validated therapeutic target for RAS/RAF wild-type colorectal cancer (CRC). However, monoclonal antibody-based anti-EGFR therapies such as cetuximab have limited effectiveness. Herein, it is identified that EGFR internalization is associated with poor treatment response and prognosis in patients with CRC, based on a retrospective analysis of patients treated with cetuximab. It is further demonstrated that the endocytosis inhibitor prochlorperazine (PCZ) can move EGFR, which is hidden inside the cell, to the cell surface to improve therapeutic antibody binding. Thus, a thermosensitive hydrogel co-loaded with cetuximab and PCZ (Gel@Cmab/PCZ) is constructed for sustained inhibition of endocytosis and effective cetuximab delivery. Peritumoral injection of Gel@Cmab/PCZ shows strong antitumor efficacy in subcutaneous and orthotopic CRC tumor models and completely abrogated liver metastasis when combined with chemotherapy. In a humanized patient-derived xenograft model, a single injection of Gel@Cmab/PCZ with one-third of the conventional cetuximab dose achieved 91% tumor growth inhibition, which promoted NK cell infiltration into tumor tissues and their antibody-dependent cell-mediated cytotoxicity effect. This study represents a novel strategy to boost the monoclonal antibody-mediated anti-tumor response in CRC.}, archive = {J_ADVS}, author = {Chong Wu and Xiaoting Liu and Rong Liu and Shiyao Song and Zi-Fan Zheng and Yilin Zeng and Yong Mei and Jing-Yang Zhang and Qijia Duan and Run Lin and Jin-Zhi Du and Weiling He}, doi = {10.1002/advs.202407239}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407239}, shortjournal = {Adv. Sci.}, title = {Sustained endocytosis inhibition via locally-injected drug-eluting hydrogel improves ADCC-mediated antibody therapy in colorectal cancer}, volume = {12}, year = {2025}, }
• (2025). Rational design of biocompatible Ir(III) photosensitizer to overcome drug-resistant cancer via oxidative autophagy inhibition. ADVS, 12(2), 2407236. (www)

  @article{ , abstract = {Autophagy is a crucial quality control mechanism that degrades damaged cellular components through lysosomal fusion with autophagosomes. However, elevated autophagy levels can promote drug resistance in cancer cells, enhancing their survival. Downregulation of autophagy through oxidative stress is a clinically promising strategy to counteract drug resistance, yet precise control of oxidative stress in autophagic proteins remains challenging. Here, a molecular design strategy of biocompatible neutral Ir(III) photosensitizers is demonstrated, B2 and B4, for precise reactive oxygen species (ROS) control at lysosomes to inhibit autophagy. The underlying molecular mechanisms for the biocompatibility and lysosome selectivity of Ir(III) complexes are explored by comparing B2 with the cationic or the non-lysosome-targeting analogs. Also, the biological mechanisms for autophagy inhibition via lysosomal oxidation are explored. Proteome analyses reveal significant oxidation of proteins essential for autophagy, including lysosomal and fusion-mediator proteins. These findings are verified in vitro, using mass spectrometry, live cell imaging, and a model SNARE complex. The anti-tumor efficacy of the precise lysosomal oxidation strategy is further validated in vivo with B4, engineered for red light absorbance. This study is expected to inspire the therapeutic use of spatiotemporal ROS control for sophisticated modulation of autophagy.}, archive = {J_ADVS}, author = {Mingyu Park and Jung Seung Nam and Taehyun Kim and Gwangsu Yoon and Seoyoon Kim and Chaiheon Lee and Chae Gyu Lee and Sungjin Park and Kochan S. Bejoymohandas and Jihyeon Yang and Yoon Hee Kwon and Yoo Jin Lee and Jeong Kon Seo and Duyoung Min and Taiho Park and Tae-Hyuk Kwon}, doi = {10.1002/advs.202407236}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407236}, shortjournal = {Adv. Sci.}, title = {Rational design of biocompatible Ir(III) photosensitizer to overcome drug-resistant cancer via oxidative autophagy inhibition}, volume = {12}, year = {2025}, }
• (2025). Bioinspired microhinged actuators for active mechanism-based metamaterials. ADVS, 12(2), 2407231. (www)

  @article{ , abstract = {Mechanism-based metamaterials, comprising rigid elements interconnected by flexible hinges, possess the potential to develop intelligent micromachines with programmable motility and morphology. However, the absence of efficient microactuators has constrained the ability to achieve multimodal locomotion and active shape-morphing behaviors at the micro and nanoscale. In this study, inspiration from the flight mechanisms of tiny insects is drawn to develop a biomimetic microhinged actuator by integrating compliant mechanisms with soft hydrogel muscle. A Pseudo-Rigid-Body mechanical model is introduced to analyze structural deformation, demonstrating that this hydrogel-based microactuator can undergo significant folding while maintaining high structural stiffness. Furthermore, multiple microhinged actuators are combined to facilitate folding in multiple degrees of freedom and arbitrary directions. Fabricated by a multi-step four-dimensional (4D) direct laser writing technique, the microhinged actuators are integrated into 2D and 3D metamaterials enabling programable shape morphing. Additionally, micro-kirigami with photonic structures is demonstrated to show the pattern transforming actuated by the microhinges. This bioinspired design approach opens new avenues for the development of active mechanism-based metamaterials capable of intricate shape-morphing behaviors.}, archive = {J_ADVS}, author = {Zi-Yi Cao and Huayang Sai and Weiwei Wang and Kai-Cheng Yang and Linlin Wang and Pengyu Lv and Huiling Duan and Tian-Yun Huang}, doi = {10.1002/advs.202407231}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407231}, shortjournal = {Adv. Sci.}, title = {Bioinspired microhinged actuators for active mechanism-based metamaterials}, volume = {12}, year = {2025}, }
• (2025). Ginkgetin alleviates inflammation and senescence by targeting STING. ADVS, 12(2), 2407222. (www)

  @article{ , abstract = {Ginkgo biloba extract is reported to have therapeutic effects on aging-related disorders. However, the specific component responsible for this biological function and its mechanism of action remain largely unknown. This study finds that Ginkgetin, an active ingredient of Ginkgo biloba extract, can alleviate cellular senescence and improve pathologies in multiple tissues of aging mice. To reveal the molecular mechanism of Ginkgetin's anti-aging effect, a graph convolutional network-based drug “on-target” pathway prediction algorithm for prediction is employed. The results indicate that the cGAS-STING pathway may be a potential target for Ginkgetin. Subsequent cell biological and biophysical data confirmed that Ginkgetin directly binds to the carboxy-terminal domain of STING protein, thereby inhibiting STING activation and signal transduction. Furthermore, in vivo pharmacodynamic data showed that Ginkgetin effectively alleviates systemic inflammation in Trex1 −/− mice and inhibits the abnormally activated STING signaling in aging mouse model. In summary, this study, utilizing an artificial intelligence algorithm combined with pharmacological methods, confirms STING serves as a critical target for Ginkgetin in alleviating inflammation and senescence. Importantly, this study elucidates the specific component and molecular mechanism underlying the anti-aging effect of Ginkgo biloba extract, providing a robust theoretical basis for its therapeutic use.}, archive = {J_ADVS}, author = {Yadan Liu and Jialin Ye and Zisheng Fan and Xiaolong Wu and Yinghui Zhang and Ruirui Yang and Bing Jiang and Yajie Wang and Min Wu and Jingyi Zhou and Jingyi Meng and Zhiming Ge and Guizhen Zhou and Yuan Zhu and Yichuan Xiao and Mingyue Zheng and Sulin Zhang}, doi = {10.1002/advs.202407222}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407222}, shortjournal = {Adv. Sci.}, title = {Ginkgetin alleviates inflammation and senescence by targeting STING}, volume = {12}, year = {2025}, }
• (2025). Terahertz resonant emission by optically excited infrared-active shear phonons in KY(MoO4)2. ADVS, 12(2), 2407028. (www)

  @article{ , abstract = {The generation of monochromatic electromagnetic radiation in the terahertz (THz) frequency range has remained a challenging task for many decades. Here, the emission of monochromatic sub-THz radiation by optical phonons in the dielectric material KY(MoO 4 ) 2 is demonstrated. The layered crystal structure of KY(MoO 4 ) 2 causes infrared-active shear lattice vibrations to have energies below 3.7 meV, corresponding to frequencies lower than 900 GHz where solid-state-based monochromatic radiation sources are rare. Directly excited by a 5 ps long broadband THz pulse, infrared-active optical vibrations in KY(MoO 4 ) 2 re-emit narrowband sub-THz radiation as a time-varying dipole for tens of picoseconds, which is exceptionally long for oscillators with frequencies below 1 THz. Such a long coherent emission allows for the detection of more than 50 periods of radiation with frequencies of 568 and 860 GHz. The remarkably long decay time together with the chemical stability of the employed material suggests a variety of possible applications in THz technology.}, archive = {J_ADVS}, author = {Dmytro Kamenskyi and Kirill Vasin and Lilian Prodan and Khrystyna Kutko and Volodymyr Khrustalyov and Sergey G. Pavlov and Heinz-Wilhelm Hübers}, doi = {10.1002/advs.202407028}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2407028}, shortjournal = {Adv. Sci.}, title = {Terahertz resonant emission by optically excited infrared-active shear phonons in KY(MoO4)2}, volume = {12}, year = {2025}, }
• (2025). Unsupervised learning-assisted acoustic-driven nano-lens holography for the ultrasensitive and amplification-free detection of viable bacteria. ADVS, 12(2), 2406912. (www)

  @article{ , abstract = {Bacterial infection is a crucial factor resulting in public health issues worldwide, often triggering epidemics and even fatalities. The accurate, rapid, and convenient detection of viable bacteria is an effective method for reducing infections and illness outbreaks. Here, an unsupervised learning–assisted and surface acoustic wave–interdigital transducer-driven nano-lens holography biosensing platform is developed for the ultrasensitive and amplification-free detection of viable bacteria. The monitoring device integrated with the nano-lens effect can achieve the holographic imaging of polystyrene microsphere probes in an ultra-wide field of view (∽28.28 mm 2 ), with a sensitivity limit of as low as 99 nm. A lightweight unsupervised learning hologram processing algorithm considerably reduces training time and computing hardware requirements, without requiring datasets with manual labels. By combining phage–mediated viable bacterial DNA extraction and enhanced CRISPR–Cas12a systems, this strategy successfully achieves the ultrasensitive detection of viable Salmonella in various real samples, demonstrating enhanced accuracy validated with the qPCR benchmark method. This approach has a low cost (∽$500) and is rapid (∽1 h) and highly sensitive (∽38 CFU mL −1 ), allowing for the amplification-free detection of viable bacteria and emerging as a powerful tool for food safety inspection and clinical diagnosis.}, archive = {J_ADVS}, author = {Yang Zhou and Junpeng Zhao and Junping Wen and Ziyan Wu and Yongzhen Dong and Yiping Chen}, doi = {10.1002/advs.202406912}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2406912}, shortjournal = {Adv. Sci.}, title = {Unsupervised learning-assisted acoustic-driven nano-lens holography for the ultrasensitive and amplification-free detection of viable bacteria}, volume = {12}, year = {2025}, }
• (2025). Integrin β8 facilitates macrophage infiltration and polarization by regulating CCL5 to promote LUAD progression. ADVS, 12(2), 2406865. (www)

  @article{ , abstract = {The tumor microenvironment (TME) influences cancer progression and metastasis. Integrin β 8 (ITG β 8), a member of the integrin family, is upregulated in various cancers. In this study, it is determined as a key factor that mediates the interaction between lung adenocarcinoma (LUAD) cells and macrophages. Increased expression levels of ITG β 8 are associated with increased numbers of CD163+ macrophages and poor prognosis in LUAD patients. The overexpression of ITG β 8 in LUAD cells promotes the polarization of THP-1 macrophages toward the M2 phenotype. In contrast, TCM (conditioned medium from the co-culture system) from THP-1 macrophages and ITG β 8-overexpressing A549 cells promoted the proliferation and invasion of A549 cells. Mechanistically, chemokine (C-C motif) ligand 5 (CCL5) plays an important role in mediating ITG β 8-induced macrophage polarization, and the phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (AKT)/interferon regulatory factor 9 (IRF9) pathway is involved in this process. Moreover, interleukin 8 (IL8) and interleukin 10 (IL10) produced by M2-like macrophages regulate the expression of ITG β 8 in LUAD cells through the spi-1 proto-oncogene (SPI1). This study elucidates the feedback mechanism of ITG β 8 between LUAD cells and macrophages.}, archive = {J_ADVS}, author = {Lei Song and Xi Yu and Yang Wu and Wenwen Zhang and Yu Zhang and Yanchi Shao and Zhenxin Hou and Chen Yang and Yue Gao and Yanbin Zhao}, doi = {10.1002/advs.202406865}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2406865}, shortjournal = {Adv. Sci.}, title = {Integrin β8 facilitates macrophage infiltration and polarization by regulating CCL5 to promote LUAD progression}, volume = {12}, year = {2025}, }
• (2025). Deficiency of FABP7 triggers premature neural differentiation in idiopathic normocephalic autism organoids. ADVS, 12(2), 2406849. (www)

  @article{ , abstract = {Autism spectrum disorder (ASD), which is caused by heterogeneous genetic and environmental factors, is characterized by diverse clinical phenotypes linked to distinct pathological mechanisms. ASD individuals with a shared clinical phenotype might contribute to revealing the molecular mechanism underlying ASD progression. Here, it is generated induced pluripotent stem cell (iPSC)-derived cerebral organoids from normocephalic individuals with ASD in a prospective birth cohort with a shared clinical diagnosis. Multiple cell lines and time series scRNA-seq combined with a histomorphological analysis revealed premature neural differentiation of neural stem cells (NSCs) and decreased expression of Fatty acid binding protein 7 (FABP7) in ASD organoids. It is subsequently revealed alterations in the phosphorylation levels of Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2), which are downstream of FABP7, and the regulation of the FABP7/MEK pathway reversed improper neural differentiation in the ASD organoids. Moreover, both Fabp7-knockdown and MEK2-overexpressing mice exhibited repetitive stereotyped behaviors and social defects relevant to autism. This study reveals the role of the FABP7/MEK pathway in abnormal NSC differentiation in normocephalic individuals with ASD, which might provide a promising therapeutic target for ASD treatment.}, archive = {J_ADVS}, author = {Xiao Han and Yuanlin He and Yuanhao Wang and Wenzhu Hu and Chu Chu and Lei Huang and Yuan Hong and Lu Han and Xu Zhang and Yao Gao and Yuan Lin and Hongxia Ma and Hongbing Shen and Xiaoyan Ke and Yan Liu and Zhibin Hu}, doi = {10.1002/advs.202406849}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2406849}, shortjournal = {Adv. Sci.}, title = {Deficiency of FABP7 triggers premature neural differentiation in idiopathic normocephalic autism organoids}, volume = {12}, year = {2025}, }
• (2025). Time-lapse acquisition of both freely secreted proteome and exosome encapsulated proteome in live organoids’ microenvironment. ADVS, 12(2), 2406509. (www)

  @article{ , abstract = {Proteomic communications in neighboring microenvironments during early organ development is a dynamic process that continuously reshapes human embryonic stem cells (hESCs) developmental fate. Such dynamic proteomic alteration in the microenvironment consists of both freely secreted proteome and exosome-encapsulated proteome. Simultaneous monitoring of the time-lapse shift of both proteomes with live organoids remains technically challenging. Here, a c ontinuous o rganoid s ecretion/ e ncapsulation p roteome tandem LC-MS/MS (COSEP-LCM) is introduced, which permits time-lapse monitoring of proteomic alterations both in free secretion form and in exosome encapsulated form at live organoids’ microenvironment. Continuous growth of human cerebral organoids (COs) and free-secretion/exosome-encapsulation proteomics acquisition with COSEP-LCM for 60 days is demonstrated. SERPINF1, F5, and EFNB1 are initially enriched inside exosomes as encapsulated excretion and then gradually enriched outside exosomes as freely secreted excretion, while C3 is initially enriched outside exosomes as freely secreted excretion and gradually enriched inside exosomes as encapsulated excretion. Such dynamic excretion pattern paradigm shift may imply critical developmental strategy evolution during early human cerebral development. COSEP-LCM offers a platform technique for continuous inside/outside exosome proteomics co-analysis in live organoids’ microenvironment.}, archive = {J_ADVS}, author = {Haoni Yan and Aynur Abdulla and Aiting Wang and Shuyu Ding and Manlin Zhang and Yizhi Zhang and Tsz Yui Zhuang and Leqi Wu and Yan Wang and Rongrong Ren and Lai Jiang and Xianting Ding}, doi = {10.1002/advs.202406509}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2406509}, shortjournal = {Adv. Sci.}, title = {Time-lapse acquisition of both freely secreted proteome and exosome encapsulated proteome in live organoids’ microenvironment}, volume = {12}, year = {2025}, }
• (2025). Highly tunable, nanomaterial-functionalized structural templating of intracellular protein structures within biological species. ADVS, 12(2), 2406492. (www)

  @article{ , abstract = {Inside living organisms, proteins are self-assembled into diverse 3D structures optimized for specific functions. This structure-function relationship can be exploited to synthesize functional materials through biotemplating and depositing functional materials onto protein structures. However, conventional biotemplating faces limitations due to the predominantly intracellular existence of proteins and associated challenges in achieving tunability while preserving functionality. In this study, Conversion to Advanced Materials via labeled Biostructures (CamBio), an integrated biotemplating platform that involves labeling target protein structures with antibodies followed by the growth of functional materials, ensuring outstanding nanostructure tunability is proposed. Protein-derived plasmonic nanostructures created by CamBio can serve as precise quantitative tools for assessing target species is demonstrated. The assessment is achieved through highly tunable and efficient surface-enhanced Raman spectroscopy (SERS). CamBio enables the formation of dense nanogap hot spots among metal nanoparticles, templated by diverse fibrous proteins comprising densely repeated monomers. Furthermore, iterative antibody labeling strategies to adjust the antibody density surrounding targets, amplifying the number of nanogaps and consequently improving SERS performance are employed. Finally, cell-patterned substrates and whole meat sections as SERS substrates, confirming their easily accessible, cost-effective, scalable preparation capabilities and dimensional tunability are incorporated.}, archive = {J_ADVS}, author = {Dae-Hyeon Song and Chang Woo Song and Seunghee H. Cho and Tae Yoon Kwon and Hoeyun Jung and Ki Hyun Park and Jiyun Kim and Junyoung Seo and Jaeyoung Yoo and Minjoon Kim and Gyu Rac Lee and Jisung Hwang and Hyuck Mo Lee and Jonghwa Shin and Jennifer H. Shin and Yeon Sik Jung and Jae-Byum Chang}, doi = {10.1002/advs.202406492}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2406492}, shortjournal = {Adv. Sci.}, title = {Highly tunable, nanomaterial-functionalized structural templating of intracellular protein structures within biological species}, volume = {12}, year = {2025}, }
• (2025). Local exosome inhibition potentiates mild photothermal immunotherapy against breast cancer. ADVS, 12(2), 2406328. (www)

  @article{ , abstract = {Limited immune infiltration within the tumor microenvironment (TME) hampers the efficacy of immune checkpoint blockade (ICB) therapy. To enhance immune infiltration, mild photothermal therapy (PTT) is often combined with immunotherapy. However, the impact of mild PTT on the TME remains unclear. The bioinformatics analyses reveal that mild PTT amplifies immune cell infiltration and stimulates T-cell activity. Notably, it accelerates the release of tumor cell-derived exosomes (T EX ) and upregulates PD-L1 expression on both tumor cells and T EX . Consequently, it is proposed that locally inhibiting T EX release is crucial for overcoming the adverse effects of mild PTT, thereby enhancing ICB therapy. Thus, a multi-stage drug delivery system is designed that concurrently delivers photosensitizers (reduced graphene oxide nanosheets, NRGO), anti-PD-L1 antibodies, and exosome inhibitors (sulfisoxazole). The system employs a temperature-sensitive lipid gel as the primary carrier, with NRGO serving as a secondary carrier that supports photothermal conversion and incorporation of sulfisoxazole. Importantly, controlled drug release is achieved using near-infrared radiation. The findings indicate that this local combination therapy remodels the immunosuppressive TME through exosome inhibition and enhanced immune cell infiltration, while also boosting T-cell activity to trigger systemic antitumor immunity, showcasing the remarkable efficacy of this combination strategy in eradicating cold tumors.}, archive = {J_ADVS}, author = {Qian Chen and Yanan Li and Jiameng Hu and Zhenyu Xu and Shengyi Wang and Naicong Cai and Mengjiao He and Yifang Xiao and Yuan Ding and Mengjuan Sun and Chunjiayu Li and Yiyang Cao and Zhongyuan Wang and Fang Zhou and Guangji Wang and Chen Wang and Jiasheng Tu and Haiyang Hu and Chunmeng Sun}, doi = {10.1002/advs.202406328}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2406328}, shortjournal = {Adv. Sci.}, title = {Local exosome inhibition potentiates mild photothermal immunotherapy against breast cancer}, volume = {12}, year = {2025}, }
• (2025). Free cholesterol-induced liver injury in non-alcoholic fatty liver disease: Mechanisms and a therapeutic intervention using dihydrotanshinone i. ADVS, 12(2), 2406191. (www)

  @article{ , abstract = {Build-up of free cholesterol (FC) substantially contributes to the development and severity of non-alcoholic fatty liver disease (NAFLD). Here, we investigate the specific mechanism by which FC induces liver injury in NAFLD and propose a novel therapeutic approach using dihydrotanshinone I (DhT). Rather than cholesterol ester (CE), we observed elevated levels of total cholesterol, FC, and alanine transaminase (ALT) in NAFLD patients and high-cholesterol diet-induced NAFLD mice compared to those in healthy controls. The FC level demonstrated a positive correlation with the ALT level in both patients and mice. Mechanistic studies revealed that FC elevated reactive oxygen species level, impaired the function of lysosomes, and disrupted lipophagy process, consequently inducing cell apoptosis. We then found that DhT protected mice on an HCD diet, independent of gut microbiota. DhT functioned as a potent ligand for peroxisome proliferator-activated receptor α (PPARα), stimulating its transcriptional function and enhancing catalase expression to lower reactive oxygen species (ROS) level. Notably, the protective effect of DhT was nullified in mice with hepatic PPARα knockdown. Thus, these findings are the first to report the detrimental role of FC in NAFLD, which could lead to the development of new treatment strategies for NAFLD by leveraging the therapeutic potential of DhT and PPARα pathway.}, archive = {J_ADVS}, author = {Jia-Wen Shou and Juncai Ma and Xuchu Wang and Xiao-Xiao Li and Shu-Cheng Chen and Byung-Ho Kang and Pang-Chui Shaw}, doi = {10.1002/advs.202406191}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2406191}, shortjournal = {Adv. Sci.}, title = {Free cholesterol-induced liver injury in non-alcoholic fatty liver disease: Mechanisms and a therapeutic intervention using dihydrotanshinone i}, volume = {12}, year = {2025}, }
• (2025). Postbiotics from lactobacillus johnsonii activates gut innate immunity to mitigate alcohol-associated liver disease. ADVS, 12(2), 2405781. (www)

  @article{ , abstract = {Prolonged alcohol consumption disrupts the gut microbiota and the immune system, contributing to the pathogenesis of alcohol-associated liver disease (ALD). Probiotic-postbiotic intervention strategies can effectively relieve ALD by maintaining gut homeostasis. Herein, the efficacy of heat-killed Lactobacillus johnsonii (HKLJ) in mitigating alcoholic liver damage is demonstrated in mouse models of ALD. The gut-liver axis is identified as a pivotal pathway for the protective effects of L. johnsonii against ALD. Specifically, HKLJ is found to upregulate the expression of intestinal lysozymes, thereby enhancing the production of immunoregulatory substances from gut bacteria, which subsequently activated the Nucleotide-binding oligomerization domain 2 (NOD2)-interleukin (IL-23)-IL-22 innate immune axis. The elevated IL-22 upregulated the antimicrobial peptide synthesis to maintain intestinal homeostasis and moreover activated the Signal transducer and activator of Transcription3 (STAT3) pathway in the liver to facilitate the repair of hepatic injuries. The heat-killed L. johnsonii provoked immunity helps correct the gut microbiota dysbiosis, specifically by reversing the reduction of butyrate-producing bacteria (such as Faecalibaculum rodentium ) and the expansion of opportunistic pathogens (such as Helicobacter sp. and Pichia kudriavzevii ) induced by ethanol. The findings provide novel insights into the gut microbiota-liver axis that may be leveraged to enhance the treatment of ALD.}, archive = {J_ADVS}, author = {Ruopeng Yin and Tao Wang and Jingzu Sun and Huanqin Dai and Yuting Zhang and Ningning Liu and Hongwei Liu}, doi = {10.1002/advs.202405781}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2405781}, shortjournal = {Adv. Sci.}, title = {Postbiotics from lactobacillus johnsonii activates gut innate immunity to mitigate alcohol-associated liver disease}, volume = {12}, year = {2025}, }
• (2025). Emergent self-adaptation in an integrated photonic neural network for backpropagation-free learning. ADVS, 12(2), 2404920. (www)

  @article{ , abstract = {Plastic self-adaptation, nonlinear recurrent dynamics and multi-scale memory are desired features in hardware implementations of neural networks, because they enable them to learn, adapt, and process information similarly to the way biological brains do. In this work, these properties occurring in arrays of photonic neurons are experimentally demonstrated. Importantly, this is realized autonomously in an emergent fashion, without the need for an external controller setting weights and without explicit feedback of a global reward signal. Using a hierarchy of such arrays coupled to a backpropagation-free training algorithm based on simple logistic regression, a performance of 98.2% is achieved on the MNIST task, a popular benchmark task looking at classification of written digits. The plastic nodes consist of silicon photonics microring resonators covered by a patch of phase-change material that implements nonvolatile memory. The system is compact, robust, and straightforward to scale up through the use of multiple wavelengths. Moreover, it constitutes a unique platform to test and efficiently implement biologically plausible learning schemes at a high processing speed.}, archive = {J_ADVS}, author = {Alessio Lugnan and Samarth Aggarwal and Frank Brückerhoff-Plückelmann and C. David Wright and Wolfram H. P. Pernice and Harish Bhaskaran and Peter Bienstman}, doi = {10.1002/advs.202404920}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2404920}, shortjournal = {Adv. Sci.}, title = {Emergent self-adaptation in an integrated photonic neural network for backpropagation-free learning}, volume = {12}, year = {2025}, }
• (2025). Spatial and single-cell transcriptomics unraveled spatial evolution of papillary thyroid cancer. ADVS, 12(2), 2404491. (www)

  @article{ , abstract = {Recurrence and metastasis are the major issues for papillary thyroid cancer (PTC). Current morphological and molecular classification systems are not satisfied for PTC diagnosis due to lacking variant-specific morphological criteria and high signal-to-noise in mutation-based diagnosis, respectively. Importantly, intratumor heterogeneity is largely lost in current molecular classification system, which can be resolved by single cell RNA sequencing (scRNA-seq). However, scRNA-seq loses spatial information and morphological features. Herein, scRNA-seq is integrated and spatially-resolved transcriptomics (SRT) to elaborate the mechanisms underlying the spatial heterogeneity, malignancy and metastasis of PTCs by associating transcriptome and local morphology. This results demonstrated that PTC cells evolved with multiple routes, driven by the enhanced aerobic metabolism and the suppressed mRNA translation and protein synthesis and the involvement of cell–cell interaction. Two curated malignant and metastatic footprints can discriminate PTC cells from normal thyrocytes. Ferroptosis resistance contributed to PTC evolution. This results will advance the knowledge of intratumor spatial heterogeneity and evolution of PTCs at spatial and single-cell levels, and propose better diagnostic strategy.}, archive = {J_ADVS}, author = {Guangzhe Zheng and Shaobo Chen and Wanqi Ma and Quanshu Wang and Li Sun and Changwen Zhang and Ge Chen and Shuping Zhang and Shuguang Chen}, doi = {10.1002/advs.202404491}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2404491}, shortjournal = {Adv. Sci.}, title = {Spatial and single-cell transcriptomics unraveled spatial evolution of papillary thyroid cancer}, volume = {12}, year = {2025}, }
• (2025). γδ t cell-mediated tumor immunity is tightly regulated by STING and TGF-β signaling pathways. ADVS, 12(2), 2404432. (www)

  @article{ , abstract = {The STING pathway plays a critical role in tumor immunosurveillance. However, the precise mechanisms by which STING regulates gamma delta (γδ) T cell function during tumor progression remain unclear. Herein, we find that tumor-derived cyclic GMP-AMP (cGAMP) activates a distinct STING pathway by inducing TBK1-mediated phosphorylation of Eomes in γδ T cells during the early stage of tumor development is demonstrated. This activation leads to interferon-gamma (IFN-γ) production and consequent tumor surveillance. However, at advanced stages of tumor progression, the accumulation of immune-suppressive cytokine transforming growth factor-beta (TGF-β) downregulates STING levels, compromising the function of γδ T cells. Notably, the synergism between TGF-β inhibition and STING agonists effectively counteracts the immunosuppressive tumor microenvironment, thereby augmenting the antitumoral effects of γδ T cells. These findings present a novel mechanism involving STING-mediated IFN-γ production in γδ T cells and hold significant implications for the development of potent immunotherapeutic approaches against cancer.}, archive = {J_ADVS}, author = {Jing Luo and Shengli Wang and Quanli Yang and Qianqian Fu and Chuyun Zhu and Tao Li and Shuxian Yang and Yin Zhao and Rong Guo and Xiaosong Ben and Yuzhen Zheng and Sitao Li and Guang Yang and Hongru Zhang and Hui Xiao and Zhengfan Jiang and Nan Yan and Dieter Kabelitz and Guodong Sun and Zvi Granot and Ligong Lu and Fuping You and Jianlei Hao and Zhinan Yin}, doi = {10.1002/advs.202404432}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2404432}, shortjournal = {Adv. Sci.}, title = {γδ t cell-mediated tumor immunity is tightly regulated by STING and TGF-β signaling pathways}, volume = {12}, year = {2025}, }
• (2025). Elucidating the molecular mechanisms and comprehensive effects of sludge-derived plant biostimulants on crop growth: Insights from metabolomic analysis. ADVS, 12(2), 2404210. (www)

  @article{ , abstract = {The utilization of urban waste for land management plays a crucial role in reshaping material flows between human activities and the environment. Sewage sludge alkaline thermal hydrolysis (ATH) produces sludge-derived plant biostimulants (SPB), which have garnered attention due to the presence of indole-3-acetic acid. However, there remains a gap in understanding SPB's molecular-level effects and its comprehensive impact on crops throughout their growth cycle. In this study, non-targeted and targeted metabolomic approaches are employed to analyze 51 plant hormones and 1,177 metabolites, revealing novel insights. The findings demonstrate that low concentrations of SPB exerted multiple beneficial effects on rice roots, leaves, and the root-soil system, facilitating rapid cell division and enhancing antioxidant defense mechanisms. These results provide a vital foundation for understanding ATH metabolic pathways and advocating for widespread SPB application, offering significant implications for sustainable land management.}, archive = {J_ADVS}, author = {Yu Hua and Shuxian Chen and Tong Tong and Xiaoou Li and Rongting Ji and Qiujin Xu and Yue Zhang and Xiaohu Dai}, doi = {10.1002/advs.202404210}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2404210}, shortjournal = {Adv. Sci.}, title = {Elucidating the molecular mechanisms and comprehensive effects of sludge-derived plant biostimulants on crop growth: Insights from metabolomic analysis}, volume = {12}, year = {2025}, }
• (2025). WAC facilitates mitophagy-mediated MSC osteogenesis and new bone formation via protecting PINK1 from ubiquitination-dependent degradation. ADVS, 12(2), 2404107. (www)

  @article{ , abstract = {Osteogenic differentiation of mesenchymal stem cells (MSCs) plays a pivotal role in the pathogenesis and treatment of bone-related conditions such as osteoporosis and bone regeneration. While the WW domain-containing coiled-coil adaptor (WAC) protein is primarily associated with transcriptional regulation and autophagy, its involvement in MSC osteogenesis remains unclear. Here, the data reveal that the levels of WAC are diminished in both osteoporosis patients and osteoporosis mouse models. It plays a pivotal function in facilitating MSC osteogenesis and enhancing new bone formation both in vitro and in vivo. Mechanistically, WAC promotes MSC osteogenesis by protecting PINK1, a crucial initiator of mitophagy, from ubiquitination-dependent degradation thereby activating mitophagy. Interestingly, WAC interacts with the TM domains of PINK1 and prevents the K137 site from ubiquitination modification. The study elucidates the mechanism by which WAC modulates MSC osteogenesis, binds to PINK1 to protect it from ubiquitination, and identifies potential therapeutic targets for osteoporosis and bone defect repair.}, archive = {J_ADVS}, author = {Shuai Fan and Jinteng Li and Guan Zheng and Ziyue Ma and Xiaoshuai Peng and Zhongyu Xie and Wenjie Liu and Wenhui Yu and Jiajie Lin and Zepeng Su and Peitao Xu and Peng Wang and Yanfeng Wu and Huiyong Shen and Guiwen Ye}, doi = {10.1002/advs.202404107}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2404107}, shortjournal = {Adv. Sci.}, title = {WAC facilitates mitophagy-mediated MSC osteogenesis and new bone formation via protecting PINK1 from ubiquitination-dependent degradation}, volume = {12}, year = {2025}, }
• (2025). Cancer cell-derived exosomal miR-500a-3p modulates hepatic stellate cell activation and the immunosuppressive microenvironment. ADVS, 12(2), 2404089. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) mainly depends on liver fibrosis/cirrhosis, which is regulated by tumor cells and the tumor microenvironment (TME), and is a crucial factor in tumor progression. This study aimed to identify abnormally expressed miR-500a-3p in the hepatitis-cirrhosis-HCC pathway and explored the roles of miR-500a-3p in HCC progression. A clinical cohort of patients with HCC is studied retrospectively. Subsequently, the role of miR-500a-3p transported by HCC exosomes in hepatic stellate cell (HSC) activation, hepatoma growth and invasion, and immune cell differentiation is determined by in vitro and in vivo experiments. In clinical tissues, miR-500a-3p is significantly enriched in HCC and cirrhosis tissues, and co-expression of the immune marker CD4 or PD-L1 significantly correlates with low survival rates in patients. Extracellular miR-500a-3p is taken up by HSC and PBMC, which promotes the secretion of the cytokines TGF-β1 and IL-10, increases PD-L1 expression in HSC, and stabilizes PD-1 expression in PBMC to affect the TME. Moreover, miR-500a-3p is associated with CD4 + T-cell exhaustion and Treg differentiation and is significantly associated with increased tumorigenicity in in situ mouse HCC models. Mechanistically, HCC-derived exosomal miR-500a-3p directly influences SOCS2 to regulate the JAK3/STAT5A/STAT5B signaling pathway. MiR-500a-3p promotes the growth and migration of HCC through the SOCS2/JAK3/STAT5A/STAT5B axis.}, archive = {J_ADVS}, author = {Yu Zhang and Xin Li and Huiyan Chen and Jiawei Li and Xiaohuan Guo and Yilin Fang and Linjie Chen and Kaiqiang Li and Yi Zhang and Fei Kong and Aodong Chen and Jianxin Lyu and Wei Zhang and Zhen Wang}, doi = {10.1002/advs.202404089}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2404089}, shortjournal = {Adv. Sci.}, title = {Cancer cell-derived exosomal miR-500a-3p modulates hepatic stellate cell activation and the immunosuppressive microenvironment}, volume = {12}, year = {2025}, }
• (2025). NSUN5 facilitates hepatocellular carcinoma progression by increasing SMAD3 expression. ADVS, 12(2), 2404083. (www)

  @article{ , abstract = {Hepatocellular carcinoma (HCC) is characterized by frequent intrahepatic and distant metastases, resulting in a poor prognosis for patients. Epithelial–mesenchymal transition (EMT) plays a pivotal role in this process. However, the expression of NOP2/Sun RNA methyltransferase 5 (NSUN5) in HCC and its role in mediating EMT remain poorly understood. In this study, clinicopathological analyses are conducted across multiple independent HCC cohorts and induced tumor formation in Nsun5-knockout mice. The findings reveal an upregulation of NSUN5 expression in tumor tissues; conversely, the absence of Nsun5 hinders the malignant progression of HCC, indicating that NSUN5 may serve as a significant oncogene in HCC. Furthermore, elevated levels of NSUN5 enhance EMT processes within HCC cells. NSUN5-knockout cells exhibit reduced invasion and migration capabilities under both in vivo and in vitro conditions, while overexpression of NSUN5 yields opposing effects. Mechanistically, high levels of NSUN5 promote the enrichment of trimethylated histone H3 at lysine 4 (H3K4me3) at the promoter region of SMAD3 through recruitment of the WDR5, thereby facilitating HCC metastasis via SMAD3-mediated EMT pathways. Collectively, this study identifies NSUN5 as a novel driver of metastasis in HCC and provides a theoretical foundation for potential therapeutic strategies against this malignancy.}, archive = {J_ADVS}, author = {Hexu Han and Chengcheng zhang and Wenbo Shi and Jiawei Wang and Wenhui Zhao and Yanping Du and Zhibin Zhao and Yifan Wang and Maosong Lin and Lei Qin and Xiaoxue Zhao and Qianqian Yin and Yiyi Liu and Zhongqi Wang and Jing Zhang and Xiaomin You and Guoxiong Zhou and Honghui Wu and Jun Ye and Xianzhong He and Weizhong Tian and Hong Yu and Yin Yuan and Qiang Wang}, doi = {10.1002/advs.202404083}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2404083}, shortjournal = {Adv. Sci.}, title = {NSUN5 facilitates hepatocellular carcinoma progression by increasing SMAD3 expression}, volume = {12}, year = {2025}, }
• (2025). Matrix metalloproteinase-responsive controlled release of self-assembly nanoparticles accelerates heart valve regeneration in situ by orchestrating immunomodulation. ADVS, 12(2), 2403351. (www)

  @article{ , abstract = {In situ tissue engineering heart valves (TEHVs) are the most promising way to overcome the defects of existing valve prostheses. Despite their promising prospects, the clinical translation of TEHVs remains a formidable challenge, mainly due to unpredictable host interactions post-implantation. An immunomodulatory idea based on hydrogel encapsulation of nanoparticle-coated heart valve scaffolds is introduced. Specifically, galactose-modified human serum albumin nanoparticles (miR-93@HSA NPs) to deliver microRNA-93 mimics are utilized, which target macrophages and induce their differentiation into the anti-inflammatory M2 subtype, fostering a conducive immune microenvironment. Matrix metalloproteinase (MMP)-responsive hydrogel is used to encapsulate the nanoparticles, enabling targeted and sustained release. Results show that the miR-93@HSA NPs exhibit excellent ability to induce macrophage polarization toward the M2 phenotype. A decellularized valve modified with hydrogel reveals MMP-response release of the miR-93@HSA NPs. In vitro, the immunomodulatory heart valve possesses good endocytocompatibility and effectively reprograms macrophages when cocultured with HUVECs or RAW264.7 macrophages. In vivo, this valve scaffold promises to mitigate early inflammatory damage and provide a pro-endothelialization niche for scaffolds' constructive remodeling. With the use of cell coculture systems and transcriptome sequencing, the mechanism of immune-modulating scaffold accelerating endothelialization is being elucidated. The immunomodulatory heart valve scaffold holds promising potential for clinical translation.}, archive = {J_ADVS}, author = {Xing Chen and Yunlong Wu and Peng Song and Liandong Feng and Ying Zhou and Jiawei Shi and Nianguo Dong and Weihua Qiao}, doi = {10.1002/advs.202403351}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2403351}, shortjournal = {Adv. Sci.}, title = {Matrix metalloproteinase-responsive controlled release of self-assembly nanoparticles accelerates heart valve regeneration in situ by orchestrating immunomodulation}, volume = {12}, year = {2025}, }
• (2025). RNA-binding protein hnrnpa1 triggers daughter cardiomyocyte formation by promoting cardiomyocyte dedifferentiation and cell cycle activity in a post-transcriptional manner. ADVS, 12(2), 2402371. (www)

  @article{ , abstract = {Stimulating cardiomyocyte (CM) dedifferentiation and cell cycle activity (DACCA) is essential for triggering daughter CM formation. In addition to transcriptional processes, RNA-binding proteins (RBPs) are emerging as crucial post-transcriptional players in regulating CM DACCA. However, whether post-transcriptional regulation of CM DACCA by RBPs could effectively trigger daughter CM formation remains unknown. By performing integrated bioinformatic analysis of snRNA-seq data from neonatal and adult hearts, this study identified Hnrnpa1 as a potential RBP regulating CM DACCA. Hnrnpa1 expression decreased significantly during postnatal heart development. With the use of α-MHC-H2B-mCh/CAG-eGFP-anillin transgenic mice, Hnrnpa1 overexpression promoted CM DACCA, thereby triggering daughter CM formation and enhancing cardiac repair after myocardial infarction (MI). In contrast, CRISPR/Cas9 technology is used to generate CM-specific Hnrnpa1 knockout mice. Hnrnpa1 knockout inhibited cardiac regeneration and worsened cardiac function in the neonatal MI model. Nanopore RNA sequencing, RIP assay, IP-MS, MeRIP-qPCR, PAR-CLIP and luciferase reporter experiments showed that Hnrnpa1 induced Mettl3 post-transcriptional splicing to inhibit m6A-dependent Pbx1 and E2F1 degradation, thereby increasing Runx1, Ccne1, Cdk2 and Ccnb2 expression to promote CM DACCA. In conclusion, Hnrnpa1 triggered daughter CM formation by promoting CM DACCA in a post-transcriptional manner, indicating that Hnrnpa1 might serve as a promising target in cardiac repair post-MI.}, archive = {J_ADVS}, author = {Chuling Li and Yijin Chen and Qiqi Chen and Haoxiang Huang and Michael Hesse and Yilin Zhou and Ming Jin and Yu Liu and Yifei Ruan and Xiang He and Guoquan Wei and Hao Zheng and Senlin Huang and Guojun Chen and Wangjun Liao and Yulin Liao and Yanmei Chen and Jianping Bin}, doi = {10.1002/advs.202402371}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2402371}, shortjournal = {Adv. Sci.}, title = {RNA-binding protein hnrnpa1 triggers daughter cardiomyocyte formation by promoting cardiomyocyte dedifferentiation and cell cycle activity in a post-transcriptional manner}, volume = {12}, year = {2025}, }
• (2025). Phosphorylation of S-S-S motif in nuclear export protein (NEP) plays a critical role in viral ribonucleoprotein (vRNP) nuclear export of influenza a and b viruses. ADVS, 12(2), 2309477. (www)

  @article{ , abstract = {The phosphorylation of three highly conserved serine residues S23, S24, and S25 (S-S-S motif) has been previously identified in NEP of influenza virus. However, it remains obscure whether and how this motif regulates the vRNPs nuclear export. Here the influenza A H5N6 viruses harboring NEP S23C, S24L, or S25L is generated, allowing to impair the phosphorylation on these sites without mutating viral NS1 protein. These mutations significantly inhibited vRNPs nuclear export are founded, decreased viral infectivity and attenuated virulence in mice. In addition, inhibition or knockout of ATM or CK2, two predicated Ser/Thr protein kinases that phosphorylate the S-S-S motif, impedes vRNP nuclear export and virus replication in cells and reduces the virulence in vivo. Moreover, treatment of NEP peptide mimics containing the S-S-S motif to competitively block NEP binding to the kinases reduces influenza virus replication in cells and mice. However, neither the inhibitors above nor the NEP peptide mimics significantly inhibit the replication of H5N6-DDD mutant, indicating phosphorylation of S-S-S motif is required for the vRNP nuclear export. This studies contribute to a better understanding of the mechanism by which NEP regulates vRNP nuclear export and provides novel insights into antiviral targets against influenza A and B viruses.}, archive = {J_ADVS}, author = {Xiaokun Liu and Cha Yang and Xian Lin and Xiaomei Sun and Huanchun Chen and Qiang Zhang and Meilin Jin}, doi = {10.1002/advs.202309477}, journal = {Advanced Science}, month = {1}, number = {2}, pages = {2309477}, shortjournal = {Adv. Sci.}, title = {Phosphorylation of S-S-S motif in nuclear export protein (NEP) plays a critical role in viral ribonucleoprotein (vRNP) nuclear export of influenza a and b viruses}, volume = {12}, year = {2025}, }
• (2025). Enhancement of single-molecule magnet properties by manipulating intramolecular dipolar interactions (Adv. sci. 1/2025). ADVS, 12(1), 2570008. (www)

  @article{ , archive = {J_ADVS}, author = {Jia-Qi Huang and Qi-Wei Chen and You-Song Ding and Xiao-Fei Zhu and Bing-Wu Wang and Feng Pan and Zhiping Zheng}, doi = {10.1002/advs.202570008}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2570008}, shortjournal = {Adv. Sci.}, title = {Enhancement of single-molecule magnet properties by manipulating intramolecular dipolar interactions (Adv. sci. 1/2025)}, volume = {12}, year = {2025}, }
• (2025). P-orbital ferromagnetism arising from unconventional o− ionic state in a new semiconductor Sr2AlO4 with insufficiently bonded oxygen (Adv. sci. 1/2025). ADVS, 12(1), 2570007. (www)

  @article{ , archive = {J_ADVS}, author = {Xu-Guang Zheng and Chao-Nan Xu and Tomoki Uchiyama and Ichihiro Yamauchi and Tomasz Galica and Eiji Nishibori and Ying Chen}, doi = {10.1002/advs.202570007}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2570007}, shortjournal = {Adv. Sci.}, title = {P-orbital ferromagnetism arising from unconventional o− ionic state in a new semiconductor Sr2AlO4 with insufficiently bonded oxygen (Adv. sci. 1/2025)}, volume = {12}, year = {2025}, }
• (2025). Non-volatile resistive switching in nanoscaled elemental tellurium by vapor transport deposition on gold (Adv. sci. 1/2025). ADVS, 12(1), 2570006. (www)

  @article{ , archive = {J_ADVS}, author = {Sara Ghomi and Christian Martella and Yoonseok Lee and Penny Hui-Ping Chang and Paolo Targa and Andrea Serafini and Davide Codegoni and Chiara Massetti and Sepideh Gharedaghi and Alessio Lamperti and Carlo Grazianetti and Deji Akinwande and Alessandro Molle}, doi = {10.1002/advs.202570006}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2570006}, shortjournal = {Adv. Sci.}, title = {Non-volatile resistive switching in nanoscaled elemental tellurium by vapor transport deposition on gold (Adv. sci. 1/2025)}, volume = {12}, year = {2025}, }
• (2025). Mapping nanoscale-to-single-cell phosphoproteomic landscape by chip-DIA (Adv. sci. 1/2025). ADVS, 12(1), 2570004. (www)

  @article{ , archive = {J_ADVS}, author = {Gul Muneer and Sofani Tafesse Gebreyesus and Ciao-Syuan Chen and Tzu-Tsung Lee and Fengchao Yu and Chih-An Lin and Min-Shu Hsieh and Alexey I. Nesvizhskii and Chao-Chi Ho and Sung-Liang Yu and Hsiung-Lin Tu and Yu-Ju Chen}, doi = {10.1002/advs.202570004}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2570004}, shortjournal = {Adv. Sci.}, title = {Mapping nanoscale-to-single-cell phosphoproteomic landscape by chip-DIA (Adv. sci. 1/2025)}, volume = {12}, year = {2025}, }
• (2025). Massively parallel screening of Toll/Interleukin-1 receptor (TIR)-derived peptides reveals multiple toll-like receptors (TLRs)-targeting immunomodulatory peptides (Adv. sci. 1/2025). ADVS, 12(1), 2570003. (www)

  @article{ , archive = {J_ADVS}, author = {Yun Lim and Tae Kyeom Kang and Meong Il Kim and Dohyeon Kim and Ji Yul Kim and Sang Hoon Jung and Keunwan Park and Wook-Bin Lee and Moon-Hyeong Seo}, doi = {10.1002/advs.202570003}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2570003}, shortjournal = {Adv. Sci.}, title = {Massively parallel screening of Toll/Interleukin-1 receptor (TIR)-derived peptides reveals multiple toll-like receptors (TLRs)-targeting immunomodulatory peptides (Adv. sci. 1/2025)}, volume = {12}, year = {2025}, }
• (2025). Ultra-low threshold resonance switching by terahertz field enhancement-induced nanobridge (Adv. sci. 1/2025). ADVS, 12(1), 2570002. (www)

  @article{ , archive = {J_ADVS}, author = {Sang-Hun Lee and Moohyuk Kim and Yeeun Roh and Myung-Ki Kim and Minah Seo}, doi = {10.1002/advs.202570002}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2570002}, shortjournal = {Adv. Sci.}, title = {Ultra-low threshold resonance switching by terahertz field enhancement-induced nanobridge (Adv. sci. 1/2025)}, volume = {12}, year = {2025}, }
• (2025). Deep learning-assisted label-free parallel cell sorting with digital microfluidics (Adv. sci. 1/2025). ADVS, 12(1), 2570001. (www)

  @article{ , archive = {J_ADVS}, author = {Zongliang Guo and Fenggang Li and Hang Li and Menglei Zhao and Haobing Liu and Haopu Wang and Hanqi Hu and Rongxin Fu and Yao Lu and Siyi Hu and Huikai Xie and Hanbin Ma and Shuailong Zhang}, doi = {10.1002/advs.202570001}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2570001}, shortjournal = {Adv. Sci.}, title = {Deep learning-assisted label-free parallel cell sorting with digital microfluidics (Adv. sci. 1/2025)}, volume = {12}, year = {2025}, }
• (2025). The second decade of advanced science – Expanding into new areas. ADVS, 12(1), 2415954. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202415954}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2415954}, shortjournal = {Adv. Sci.}, title = {The second decade of advanced science – Expanding into new areas}, volume = {12}, year = {2025}, }
• (2025). Stretchable and high-performance fibrous sensors based on ionic capacitive sensing for wearable healthcare monitoring. ADVS, 12(1), 2412859. (www)

  @article{ , abstract = {Electronic textiles with remarkable breathability, lightweight, and comfort hold great potential in wearable technologies and smart human-machine interfaces. Ionic capacitive sensors, leveraging the advantages of the electric double layer, offer higher sensitivity compared to traditional capacitive sensors. Current research on wearable ion-capacitive sensors has focused mainly on two-dimensional (2D) or three-dimensional (3D) device architectures, which show substantial challenges for direct integration with textiles and compromise their wearing experience on conformability and permeability. One-dimensional (1D) stretchable fiber materials serve as vital components in constructing electronic textiles, allowing for rich structural design, patterning, and device integration through mature textile techniques. Here, a stretchable functional fiber with robust mechanical and electrical performances is fabricated based on semi-solid metal and ionic polymer, which provided a high stretchability and good electrical conductivity, enabling seamless integration with textiles. Consequently, high-performance stretchable fiber sensors are developed through different device architecture designs, including pressure sensors with high sensitivity (7.21 kPa −1 ), fast response (60 ms/30 ms), and excellent stability, as well as strain sensors with high sensitivity (GF = 1.05), wide detection range (0–300% strain), and excellent sensing stability under dynamic deformations.}, archive = {J_ADVS}, author = {Jiawei Liu and Yan Yang and Guangchuan Chen and Hongbiao Sun and Xin Xie and Yanfeng Hou and Lishen Zhang and Jinhui Wang and Jiangxin Wang}, doi = {10.1002/advs.202412859}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2412859}, shortjournal = {Adv. Sci.}, title = {Stretchable and high-performance fibrous sensors based on ionic capacitive sensing for wearable healthcare monitoring}, volume = {12}, year = {2025}, }
• (2025). Correction to “Tumor-activatable nanoparticles target low-density lipoprotein receptor to enhance drug delivery and antitumor efficacy”. ADVS, 12(1), 2412651. (www)

  @article{ , archive = {J_ADVS}, doi = {10.1002/advs.202412651}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2412651}, shortjournal = {Adv. Sci.}, title = {Correction to “Tumor-activatable nanoparticles target low-density lipoprotein receptor to enhance drug delivery and antitumor efficacy”}, volume = {12}, year = {2025}, }
• (2025). Correction to “Flexible 3D plasmonic web enables remote surface enhanced raman spectroscopy”. ADVS, 12(1), 2412492. (www)

  @article{ , archive = {J_ADVS}, author = {E. Rodríguez-Sevilla and J. U. Álvarez-Martínez and R. Castro-Beltrán and E. Morales-Narváez}, doi = {10.1002/advs.202412492}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2412492}, shortjournal = {Adv. Sci.}, title = {Correction to “Flexible 3D plasmonic web enables remote surface enhanced raman spectroscopy”}, volume = {12}, year = {2025}, }
• (2025). Electric field cycling of physisorbed antibodies reduces biolayer polarization dispersion. ADVS, 12(1), 2412347. (www)

  @article{ , abstract = {The electric dipoles of proteins in a biolayer determine their dielectric properties through the polarization density P. Hence, its reproducibility is crucial for applications, particularly in bioelectronics. Biolayers encompassing capturing antibodies covalently bound at a biosensing interface are generally preferred for their assumed higher stability. However, surface physisorption is shown to offer advantages like easily scalable fabrication processes and high stability. The present study investigates the effects of electric-field (EF)-cycling of anti-Immunoglobulin M (anti-IgM) biolayers physisorbed on Au. The impact of EF-cycling on the dielectric, optical, and mechanical properties of anti-IgM biolayer is investigated. A reduction of the dispersion (standard deviation over a set of 31 samples) of the measured P values is observed, while the set median stays almost constant. Hence, physisorption combined with EF cycling, results in a biolayer with highly reproducible bioelectronic properties. Additionally, the study provides important insights into the mechanisms of dielectric rearrangement of dipole moments in capturing biolayers after EF-cycling. Notably, EF-cycling acts as an annealing process, driving the proteins in the biolayer into a statistically more probable and stable conformational state. Understanding these phenomena enhances the knowledge of the properties of physisorbed biolayers and can inform design strategies for bioelectronic devices.}, archive = {J_ADVS}, author = {Cinzia Di Franco and Eleonora Macchia and Michele Catacchio and Mariapia Caputo and Cecilia Scandurra and Lucia Sarcina and Paolo Bollella and Angelo Tricase and Massimo Innocenti and Riccardo Funari and Matteo Piscitelli and Gaetano Scamarcio and Luisa Torsi}, doi = {10.1002/advs.202412347}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2412347}, shortjournal = {Adv. Sci.}, title = {Electric field cycling of physisorbed antibodies reduces biolayer polarization dispersion}, volume = {12}, year = {2025}, }
• (2025). Bone-targeted fluoropeptide nanoparticle inhibits NF-κB signaling to treat osteosarcoma and tumor-induced bone destruction. ADVS, 12(1), 2412014. (www)

  @article{ , abstract = {Osteosarcoma is a malignant bone cancer usually characterized by symptoms of bone loss due to pathologically enhanced osteoclast activity. Activated osteoclasts enhance bone resorption and promote osteosarcoma cell progression by secreting various cytokines. Intercepting the detrimental interplay between osteoclasts and osteosarcoma cells is considered as an option for osteosarcoma treatment. Here, a bone-targeted fluoropeptide nanoparticle that can inhibit the nuclear factor kappa B (NF-κB) signaling in both osteoclasts and osteosarcoma to address the above issue is developed. The NF-κB essential modulator binding domain (NBD) peptide is conjugated with a fluorous tag to improve its proteolytic stability and intracellular penetration. The NBD peptide is efficiently delivered into cells after fluorination to induce apoptosis of osteocarcoma cells, and inhibits osteoclasts differentiation. The fluorous-tagged NBD peptide is further co-assembled with an oligo (aspartic acid) terminated fluoropeptide to form bone-targeted peptide nanoparticles for osteosarcoma treatment. The targeted nanoparticles efficiently inhibited tumor progression and osteosarcoma-induced bone destruction in vivo. This co-assembled fluoropeptide nanoplatform proposed in this study offers a promising approach for targeted and intracellular delivery of peptide therapeutics in the treatment of various diseases.}, archive = {J_ADVS}, author = {Lin Li and Guangyu Rong and Xin Gao and Yiyun Cheng and Zhengwang Sun and Xiaopan Cai and Jianru Xiao}, doi = {10.1002/advs.202412014}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2412014}, shortjournal = {Adv. Sci.}, title = {Bone-targeted fluoropeptide nanoparticle inhibits NF-κB signaling to treat osteosarcoma and tumor-induced bone destruction}, volume = {12}, year = {2025}, }
• (2025). Organophotocatalyst enabled deoxycyclopropanation of alcohols. ADVS, 12(1), 2411788. (www)

  @article{ , abstract = {Cyclopropane fragments, which widely exist in marketed drugs and natural products, can confer special pharmacological properties to small-molecule drugs. Therefore, developing methods to construct cyclopropanes is of great significance. Nevertheless, the introduction of cyclopropane primarily relies on already-formed cyclopropyl groups, which significantly restricts the diversity of cyclopropane skeletons. Late-stage direct cyclopropanation is still a challenging task. Herein, a photo-induced intermolecular deoxycyclopropanation reaction that employs alcohols as substrates, and 1 mol.% of 2,3,5,6-tetrakis(carbazol-9-yl)-1,4-dicyanobenzene (4CzTPN) as organophotocatalyst is reported. This method proceeds with high transformation efficiency (up to 98% yield) and exhibits broad functional group tolerance, such as primary, secondary, and tertiary alcohols as well as various activated β-halogenated alkenes. This process is mild, easy to operate, and has low equipment requirements. The power of this technology is demonstrated by the late-stage functionalization of five marketed drugs and five natural products.}, archive = {J_ADVS}, author = {Yongsheng Zhang and Jincheng Wang and Xiaoyan He and Shilin Peng and Lei Yuan and Gang Huang and Yongjin Guo and Xiuhong Lu}, doi = {10.1002/advs.202411788}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2411788}, shortjournal = {Adv. Sci.}, title = {Organophotocatalyst enabled deoxycyclopropanation of alcohols}, volume = {12}, year = {2025}, }
• (2025). Recyclable robust plastic scintillation resin achieving the exceptional separation and detection of technetium-99. ADVS, 12(1), 2411523. (www)

  @article{ , abstract = {Rapid detection and absorption of 99 TcO 4 ⁻ contamination in the environment are critical due to its high radioactivity, long half-life, and significant environmental mobility. Resins have been demonstrated effective bifunctional properties for both the detection and separation of 99 TcO 4 ⁻ . However, the poor stability of these compounds limits their practical application. Here, a chemical grafting strategy is presented to synthesize ultra-stable plastic scintillation resin, in which 4-vinylpyridine and divinylbenzene are cross-linked as matrix polymer to withstand extreme conditions and a fluorophore “shield” to convert beta radiation into detectable signals. As expected, the as-obtained resin exhibits a high adsorption capacity of 549.2 mg g ⁻¹ for 99 TcO 4 ⁻ with a rapid kinetic response of just 10 min as well as superior selectivity at 1000 times excess of interfering ions and full reusability. Moreover, it showed remarkable stability under 800 kGy, 3.0 mol L −1 HNO 3 or 2.5 L solution continuous leaching, consistently maintaining high separation and detection efficiency after recycling 10 times. This strategy paves a new way to develop stable resin for the rapid capture and accurate measurement of 99 TcO 4 ⁻ , which owns great potential for practical application.}, archive = {J_ADVS}, author = {Tonghuan Liu and Yichen Hu and Junqiang Yang and Kesheng Hu and Bei Qi and Yun Zhou and Juan Tong and Man Wang and Liang Huang and Keliang Shi and Xiaolin Hou}, doi = {10.1002/advs.202411523}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2411523}, shortjournal = {Adv. Sci.}, title = {Recyclable robust plastic scintillation resin achieving the exceptional separation and detection of technetium-99}, volume = {12}, year = {2025}, }
• (2025). Femtosecond laser-induced recrystallized nanotexturing for identity document security with physical unclonable functions. ADVS, 12(1), 2411449. (www)

  @article{ , abstract = {Counterfeit identity (ID) documents pose a serious threat to personal credit and national security. As a promising candidate, optical physical unclonable functions (PUFs) offer a robust defense mechanism against counterfeits. Despite the innovations in chemically synthesized PUFs, challenges persist, including harmful chemical treatments, low yields, and incompatibility of reaction conditions with the ID document materials. More notably, surface relief nanostructures for PUFs, such as wrinkles, are still at risk of being replicated through scanning lithography or nanoimprint. Here, a femtosecond laser-induced recrystallized silicon nanotexture is reported as latent PUF nanofingerprint for document anti-counterfeiting. With femtosecond laser irradiation, nanotextures spontaneously emerge within 100 ms of exposure. By introducing a low-absorption metal layer, surface plasmon polariton waves are excited on the silicon-metal multilayer nanofilms with long-range boosting, ensuring the uniqueness and non-replicability of the final nanotextures. Furthermore, the femtosecond laser induces a phase transition in the latent nanotexture from amorphous to polycrystalline state, rather than creating replicable relief wrinkles. The random nanotextures are easily identifiable through optical microscopy and Raman imaging, yet they remain undetectable by surface characterization methods such as scanning electron and atomic force microscopies. This property significantly hinders counterfeiting efforts, as it prevents the precise replication of these nanostructures.}, archive = {J_ADVS}, author = {Panpan Niu and Jiao Geng and Qilin Jiang and Yangyundou Wang and Jianxin Sang and Zhenghong Wang and Liping Shi}, doi = {10.1002/advs.202411449}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2411449}, shortjournal = {Adv. Sci.}, title = {Femtosecond laser-induced recrystallized nanotexturing for identity document security with physical unclonable functions}, volume = {12}, year = {2025}, }
• (2025). PH-dependent assembly and stability of toll-like receptor 3/dsRNA signaling complex: Insights from constant pH molecular dynamics and metadynamics simulations. ADVS, 12(1), 2411445. (www)

  @article{ , abstract = {The pH-dependent assembly of Toll-like receptors (TLRs), which triggers a threshold-like response, is a key principle in immune signaling. While crystallography has revealed the intricate structure of these assembly complexes, the mechanisms underlying their pH dependency remain unclear. Herein, constant pH simulations and metadynamics are employed to investigate the pH-dependent assembly and stability of the TLR3/dsRNA signaling complex. The findings demonstrate that system pH regulates complex assembly and stability by modulating the protonation and charge states of histidines. Histidines in TLR3 act as pH-dependent, positively charged binding sites that capture negatively charged dsRNA. Additionally, these histidines form a [H682⁺]—[E626⁻] dipole, facilitating the assembly of two TLR3 molecules into an antisymmetric dimer through dipole–dipole interactions. Surprisingly, TLR3 can shift the p K a values of key histidines from their model p K a of 6.5, increasing protonation likelihood and enhancing ligand binding. Notably, the aromatic residue Phe84, located within the dsRNA binding site [His39⁺–His60⁺–Phe84–His108⁺], alters the p K a of His60 through cation-π interactions with its protonated state. This study offers new insights into the molecular mechanisms underlying pH-dependent immune signaling via higher-order assemblies and suggests potential applications for histidine in self-assembling biomaterials.}, archive = {J_ADVS}, author = {Penghui Li and Mingsong Shi and Yibo Wang and Qiong Liu and Xiubo Du and Xiaohui Wang}, doi = {10.1002/advs.202411445}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2411445}, shortjournal = {Adv. Sci.}, title = {PH-dependent assembly and stability of toll-like receptor 3/dsRNA signaling complex: Insights from constant pH molecular dynamics and metadynamics simulations}, volume = {12}, year = {2025}, }
• (2025). How do the four core factors of high entropy affect the electrochemical properties of energy-storage materials?. ADVS, 12(1), 2411291. (www)

  @article{ , abstract = {High-entropy materials (HEMs) are extremely popular for electrochemical energy storage nowadays. However, the detailed effects of four core factors of high entropy on the electrochemical properties of HEMs are still unclear. Here, a high-entropy La 1/4 Ce 1/4 Pr 1/4 Nd 1/4 Nb 3 O 9 (HE-LaNb 3 O 9 ) oxide is prepared through multiple rare-metal-ion substitution in LaNb 3 O 9 , and uses HE-LaNb 3 O 9 as a model material to systematically study the effects of the four core factors of high entropy on electrochemical energy-storage materials. The high-entropy effect lowers the calcination temperature for obtaining pure HE-LaNb 3 O 9 . The lattice distortion in HE-LaNb 3 O 9 leads to its decreased unit-cell-volume variations, which benefits its cyclability. Based on the restrained diffusion arising from the lattice distortion, the Li + diffusivity of HE-LaNb 3 O 9 at room temperature (25 °C) is limited, which causes its lowered rate capability. However, the Li + diffusivity of HE-LaNb 3 O 9 at high temperature (60 °C) becomes faster than that of LaNb 3 O 9 , which is attributed to the alleviated lattice distortion at the high-temperature, resulting in higher rate capability. The cocktail effects in HE-LaNb 3 O 9 enable its larger electronic conductivity, better electrochemical activity, more intensive Nb 5+ ↔ Nb 3+ redox reaction, and larger reversible capacity. The insight gained here can provide a guide for the rational design of new HEMs with good energy-storage properties.}, archive = {J_ADVS}, author = {Wenze Wang and Qian Zhang and Liting Yang and Guisheng Liang and Xuhui Xiong and Yifeng Cheng and Limin Wu and Chunfu Lin and Renchao Che}, doi = {10.1002/advs.202411291}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2411291}, shortjournal = {Adv. Sci.}, title = {How do the four core factors of high entropy affect the electrochemical properties of energy-storage materials?}, volume = {12}, year = {2025}, }
• (2025). Targeting tRNA-derived non-coding RNA alleviates diabetes-induced visual impairment through protecting retinal neurovascular unit. ADVS, 12(1), 2411042. (www)

  @article{ , abstract = {Diabetes is a major risk factor for compromised visual health, leading to retinal vasculopathy and neuropathy, both of which are hallmarks of neurovascular unit dysfunction. Despite the critical impact of diabetic retinopathy, the precise mechanism underlying neurovascular coupling and effective strategies to suppress neurovascular dysfunction remain unclear. In this study, the up-regulation of a tRNA-derived stress-induced RNA, 5′tiRNA-His-GTG, in response to diabetic stress is revealed. 5′tiRNA-His-GTG directly regulates Müller glia action and indirectly alters endothelial angiogenic effects and retinal ganglion cell (RGC) survival in vitro. Downregulation of 5′tiRNA-His-GTG alleviates diabetes-induced retinal neurovascular dysfunction, characterized by reduced retinal vascular dysfunction, decreased retinal neurodegeneration, and improved visually-guided behaviors in vivo. Mechanistically, 5′tiRNA-His-GTG acts as a key regulator of retinal neurovascular dysfunction, primarily by modulating arachidonic acid (AA) metabolism via the CYPs pathway. The 5′tiRNA-His-GTG-CYP2E1-19(S)-HETE signaling axis is identified as a key driver of retinal neurovascular dysfunction. Thus, targeting 5′tiRNA-His-GTG presents a promising therapeutic strategy for treating vasculopathy and neuropathy associated with diabetes mellitus. Modulating this novel signaling pathway can open up new avenues for intervention in diabetic retinopathy and its related complications.}, archive = {J_ADVS}, author = {Jin Yao and Wen Yao and Jun-Ya Zhu and Yan Liu and Jin-Hong Liu and Yu-Ke Ji and Xi-Shen Ni and Wan Mu and Biao Yan}, doi = {10.1002/advs.202411042}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2411042}, shortjournal = {Adv. Sci.}, title = {Targeting tRNA-derived non-coding RNA alleviates diabetes-induced visual impairment through protecting retinal neurovascular unit}, volume = {12}, year = {2025}, }
• (2025). Iodine/Chlorine multi-electron conversion realizes high energy density zinc-iodine batteries. ADVS, 12(1), 2410988. (www)

  @article{ , abstract = {Aqueous zinc-iodine (Zn-I 2 ) batteries are promising energy storage devices; however, the conventional single-electron reaction potential and energy density of iodine cathode are inadequate for practical applications. Activation of high-valence iodine cathode reactions has evoked a compelling direction to developing high-voltage zinc-iodine batteries. Herein, ethylene glycol (EG) is proposed as a co-solvent in a water-in-deep eutectic solvent (WiDES) electrolyte, enabling significant utilization of two-electron-transfer I + /I 0 /I − reactions and facilitating an additional reversibility of Cl 0 /Cl − redox reaction. Spectroscopic characterizations and calculations analyses reveal that EG integrates into the Zn 2+ solvation structure as a hydrogen-bond donor, competitively binding O atoms in H 2 O, which triggers a transition from water-rich to water-poor clusters of Zn 2+ , effectively disrupting the H 2 O hydrogen-bond network. Consequently, the aqueous Zn-I 2 cell achieves an exceptional capacity of 987 mAh g I2 −1 with an energy density of 1278 Wh kg I2 −1 , marking an enhancement of ≈300 mAh g −1 compared to electrolyte devoid of EG, and enhancing the Coulombic efficiency (CE) from 68.2% to 98.7%. Moreover, the pouch cell exhibits 3.72 mAh cm −2 capacity with an energy density of 4.52 mWh cm −2 , exhibiting robust cycling stability. Overall, this work contributes to the further development of high-valence and high-capacity aqueous Zn-I 2 batteries.}, archive = {J_ADVS}, author = {Jiajin Zhao and Yan Chen and Mengyan Zhang and Ziqi An and Binbin Nian and Wenfeng Wang and Hao Wu and Shumin Han and Yuan Li and Lu Zhang}, doi = {10.1002/advs.202410988}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410988}, shortjournal = {Adv. Sci.}, title = {Iodine/Chlorine multi-electron conversion realizes high energy density zinc-iodine batteries}, volume = {12}, year = {2025}, }
• (2025). P-orbital ferromagnetism arising from unconventional o− ionic state in a new semiconductor Sr2AlO4 with insufficiently bonded oxygen. ADVS, 12(1), 2410977. (www)

  @article{ , abstract = {Oxygen in solids usually exists in an O 2− ionic state. As a result, it loses its magnetic nature of a single atom, wherein two unpaired electrons exist in its outer 2 p orbitals. Here, it is shown that an unconventional stable ionic state of O − is realized in a new semiconductor material Sr 2 AlO 4 , leading to an intrinsic p -orbital ferromagnetism stable until ≈900 K. Experimental and theoretical investigations have clarified that one-fourth of the oxygen atoms in Sr 2 AlO 4 are insufficiently bonded in the crystal structure, resulting in a unique O − -state and p -orbital ferromagnetism. To date, the O − state is reported to exist only in non-equilibrium conditions, and p -orbital magnetism is only suggested in impurity bands with small ferromagnetic moments. The present work provides a new route for creating ferromagnetism in semiconductors and exploring new p -orbital physics and chemistry. In addition, the material shows elastic-mechanoluminescence that may enable unprecedented mechano-photonic-spintronics.}, archive = {J_ADVS}, author = {Xu-Guang Zheng and Chao-Nan Xu and Tomoki Uchiyama and Ichihiro Yamauchi and Tomasz Galica and Eiji Nishibori and Ying Chen}, doi = {10.1002/advs.202410977}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410977}, shortjournal = {Adv. Sci.}, title = {P-orbital ferromagnetism arising from unconventional o− ionic state in a new semiconductor Sr2AlO4 with insufficiently bonded oxygen}, volume = {12}, year = {2025}, }
• (2025). Achieving ultra-high heat flux transfer in graphene films via tunable gas escape channels. ADVS, 12(1), 2410913. (www)

  @article{ , abstract = {Graphene films have been applied in the thermal management of electronic devices due to their high thermal conductivity. However, the ever-increasing power and local heat flux density of electronic chips require graphene films with excellent heat flux carrying capacity. Enhancing the heat flux carrying capacity is highly challenging, and the key is to maintain high thermal conductivity while increasing film thickness. Gases released during film assembly and the resulting catastrophic structural destruction should be responsible for the trade-off between film thickness and thermal conductivity. Herein, the evolution of the pore structure is investigated during the assembly of graphene films and propose the construction of gas escape channels for the preparation of thick graphene films. The process involves using humidification treatment and freeze-drying GO films to pre-construct the ordered flat pore structure. The microstructure optimization of graphene films with more order, fewer wrinkles and defects, and larger grain size is achieved. After optimization, graphene films with ultra-high thermal conductivity (1781 W m −1 K −1 ) and a thickness over 100 µm are realized. These films exhibit exceptional heat dissipation and cooling capabilities in high heat flux density (≈2000 W cm −2 ). This finding holds significant potential for guiding the thermal management of high-power devices.}, archive = {J_ADVS}, author = {Haolong Zheng and Peng He and Shujing Yang and Yonghua Lu and Na Guo and Yanhong Li and Gang Wang and Guqiao Ding}, doi = {10.1002/advs.202410913}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410913}, shortjournal = {Adv. Sci.}, title = {Achieving ultra-high heat flux transfer in graphene films via tunable gas escape channels}, volume = {12}, year = {2025}, }
• (2025). Antimicrobial peptides: A promising alternative to conventional antimicrobials for combating polymicrobial biofilms. ADVS, 12(1), 2410893. (www)

  @article{ , abstract = {Polymicrobial biofilms adhere to surfaces and enhance pathogen resistance to conventional treatments, significantly contributing to chronic infections in the respiratory tract, oral cavity, chronic wounds, and on medical devices. This review examines antimicrobial peptides (AMPs) as a promising alternative to traditional antibiotics for treating biofilm-associated infections. AMPs, which can be produced as part of the innate immune response or synthesized therapeutically, have broad-spectrum antimicrobial activity, often disrupting microbial cell membranes and causing cell death. Many specifically target negatively charged bacterial membranes, unlike host cell membranes. Research shows AMPs effectively inhibit and disrupt polymicrobial biofilms and can enhance conventional antibiotics' efficacy. Preclinical and clinical research is advancing, with animal studies and clinical trials showing promise against multidrug-resistant bacteria and fungi. Numerous patents indicate increasing interest in AMPs. However, challenges such as peptide stability, potential cytotoxicity, and high production costs must be addressed. Ongoing research focuses on optimizing AMP structures, enhancing stability, and developing cost-effective production methods. In summary, AMPs offer a novel approach to combating biofilm-associated infections, with their unique mechanisms and synergistic potential with existing antibiotics positioning them as promising candidates for future treatments.}, archive = {J_ADVS}, author = {Cesar Augusto Roque-Borda and Laura Maria Duran Gleriani Primo and Kaila Petronila Medina-Alarcón and Isabella C. Campos and Camila de Fátima Nascimento and Mauro M. S. Saraiva and Angelo Berchieri Junior and Ana Marisa Fusco-Almeida and Maria José Soares Mendes-Giannini and João Perdigão and Fernando Rogério Pavan and Fernando Albericio}, doi = {10.1002/advs.202410893}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410893}, shortjournal = {Adv. Sci.}, title = {Antimicrobial peptides: A promising alternative to conventional antimicrobials for combating polymicrobial biofilms}, volume = {12}, year = {2025}, }
• (2025). Fluorine-induced lattice oxygen participation in 2D layered double Hydroxide/MXene hybrids for efficient oxygen evolution. ADVS, 12(1), 2410812. (www)

  @article{ , abstract = {In oxygen evolution reaction (OER), the participation of lattice oxygen can break the limitation of adsorption evolution mechanism, but the activation of lattice oxygen remains a critical challenge. Herein, a surface fluorinated highly active 2D/2D FeNi layered double hydroxide/MXene (F-LDH/MX) is demonstrated, boosting OER with the enhanced lattice-oxygen-mediated path. The introduction of fluorine promotes the self-evolution of catalyst in an alkaline environment, even without an external current. It further accelerates the formation of active metal oxyhydroxides with abundant oxygen vacancies under the operating potential. The introduced oxygen vacancy activates the lattice oxygen, increasing the proportion of lattice oxygen mechanism in OER. Owing to the synergistic effects of the 2D/2D hierarchical structure and the modulated active surface, F-LDH/MX possesses excellent electrochemical performances, including a low overpotential of 251 mV at 10 mA cm −2 , a low Tafel slope of 40.28 mV dec −1 , and robust stability. The water electrolyzer system with F-LDH/MX as the anode offers the benchmark current density at a low cell voltage of 1.53 V, while the Zn-air battery with F-LDH/MX as the air electrode exhibits a higher power density of 75.43 mW cm −2 . This study presents a promising strategy to design highly active electrocatalysts for energy conversion and storage.}, archive = {J_ADVS}, author = {Chengang Pei and Min-Cheol Kim and Unbeom Baeck and Won Tae Hong and Jong Hun Kim and Hyungu Han and Jaekyum Kim and Sung Min Cho and Xu Yu and Jongwook Park and Ho Seok Park and Jung Kyu Kim}, doi = {10.1002/advs.202410812}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410812}, shortjournal = {Adv. Sci.}, title = {Fluorine-induced lattice oxygen participation in 2D layered double Hydroxide/MXene hybrids for efficient oxygen evolution}, volume = {12}, year = {2025}, }
• (2025). Triphenylamine-functionalized metal nanoclusters for efficient and stable perovskite solar cells. ADVS, 12(1), 2410796. (www)

  @article{ , abstract = {Reported herein is a ligand engineering strategy to develop photoelectric active metal nanoclusters (NCs) with atomic precision. Triphenylamine (TPA), a typical organic molecule in the photoelectric field, is introduced for the first time to prepare atomically precise metal NCs that prove effective in the fabrication of perovskite solar cells (PSCs). The scalable synthetic prototype, unique electronic strucuture, and atomically precise structure of the cluster ([(AgCu) 37 (PPh 3 ) 8 (TPA-C≡C) 24 ] 5+ ) are illustrated in this work. When being employed as a buffer layer in the perovskite/HTL interface of PSCs, significantly enhanced performance is observed. The resultant n-i-p devices achieved a substantial power conversion efficiency as high as 25.1% and long-term stability. The findings offer valuable insights into preparing functionalized metal NCs that play multiple roles in improving the performance of the device: while the inorganic metal core enhances conductivity, the organic TPA shell promotes the “carrier transfer” between the perovskite and HTL layer and prevents the perovskite from corrosion.}, archive = {J_ADVS}, author = {Lin Wang and Jieru Du and Jiahao Wu and Zi-Ang Nan and Simin Li and Xiongkai Tang and Zhenlang Xie and Qinghua Xu and Xuekun Gong and Jinlu He and Ruihao Chen and Nanfeng Zheng and Hui Shen}, doi = {10.1002/advs.202410796}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410796}, shortjournal = {Adv. Sci.}, title = {Triphenylamine-functionalized metal nanoclusters for efficient and stable perovskite solar cells}, volume = {12}, year = {2025}, }
• (2025). Gene therapy for inflammatory cascade in intrauterine injury with engineered extracellular vesicles hybrid snail mucus-enhanced adhesive hydrogels. ADVS, 12(1), 2410769. (www)

  @article{ , abstract = {Early hyper-inflammation caused by intrauterine injury triggered subsequent intrauterine adhesion (IUA). STAT1-mediated M1 macrophages are confirmed to secrete pro-inflammatory cytokines to accelerate inflammatory cascade and IUA formation by multi-omics analysis and experimental verification. However, clinically used hyaluronic acid (HA) hydrogels are prone to slip out of injury sites due to poor bio-adhesion properties. Therefore, there are still challenges in applying hydrogels for M1 macrophage intervention in IUA treatment. Herein, an engineered extracellular vesicles (EVs) hybrid snail mucus (SM)-enhanced adhesive hydrogels to improve bio-adhesion property is fabricated and M1 macrophage intervention through targeting delivery and STAT1 silencing is achieved. First, inspired by the high bio-adhesion capacity of SM, SM and gelatin methacrylate (GelMA) solution are mixed to construct GelMA/SM (GS) hydrogel. Then, folic acid-modified extracellular vesicles (FA-EVs) are synthesized for targeting the delivery of STAT1-siRNA. Upon injection of FA-EVs hybrid GS hydrogel into the uterine cavity, a protective hydrogel layer forms on the surface of injury sites and sustains the release of STAT1-siRNA-loaded FA-EVs to curtail M1 macrophages generation through inhibiting STAT1 phosphorylation, resulting in reduction of myofibroblasts activation and collagen deposition. In addition, the pregnancy rate and the number of fetuses in rats treated with this hydrogel were much higher than those in other groups, suggesting that the hydrogel could promote functional endometrial regeneration and restore fertility. Overall, this study presents a promising strategy for employing FA-EVs hybrid adhesive hydrogel with superior bio-adhesion properties and M1 macrophage targeting delivery for IUA treatment and uterus recovery.}, archive = {J_ADVS}, author = {Xiaotong Peng and Tao Wang and Bo Dai and Yiping Zhu and Mei Ji and Pusheng Yang and Jiaxin Zhang and Wenwen Liu and Yaxin Miao and Yonghang Liu and Shuo Wang and Jing Sun}, doi = {10.1002/advs.202410769}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410769}, shortjournal = {Adv. Sci.}, title = {Gene therapy for inflammatory cascade in intrauterine injury with engineered extracellular vesicles hybrid snail mucus-enhanced adhesive hydrogels}, volume = {12}, year = {2025}, }
• (2025). A turbo-charging system-like contrast agent for MRI-guided STING pathway-activated cancer immunotherapy. ADVS, 12(1), 2410432. (www)

  @article{ , abstract = {To overcome the problems of Gd-based contrast agents (GBCAs) (nephrotoxicity and brain deposition) and stimulator of interferon genes (STING) agonists (poor stability, low delivery efficiency, and potential toxicity), in this study, a Turbo-charging system-like GBCA is designed and constructed for magnetic resonance imaging (MRI) guided STING pathway-activated cancer immunotherapy. Poly(acrylic acid) (PAA) is used to coordinate with Gd 3+ , forming a Gd/PAA macrochelate. Both Gd/PAA macrochelate and SR717 are conjugated to cystamine (CA) to obtain SR717-CA@Gd/PAA self-assembled nanoparticles (SAN), which are termed as Turbo S because of its similarity with the Turbo-charging system of cars. After accumulation in tumors and internalization in tumor cells, the disulfide linkage in Turbo S undergoes a cleavage process catalyzed by glutathione (GSH), leading to the release of Gd/PAA and SR717. The released Gd/PAA gain a high r 1 value (17.11 m M −1 s −1 at 7.0 T; 57.81 m M −1 s −1 at 3.0 T), indicating its strong T 1 imaging capability. Turbo S with a low dosage of SR717 (8.9 mg kg −1 ) achieved a higher tumor immunotherapeutic efficacy than free SR717 with a high dosage (30 mg kg −1 ). The excellent delivery efficiency, high tumor treatment efficacy, and superior biosafety demonstrate that the Turbo S can be used as a promising candidate for tumor immunotherapy.}, archive = {J_ADVS}, author = {Bin Ren and Sihua Yan and Zongheng Li and Ya Huang and Haobin Cai and Jing Yang and Qingdeng Fan and Chunmei Chen and Fanchao Que and Guochao Wu and Lin Huang and Ruilong Zhou and Jiaoyang Zhu and Chenggong Yan and Gang Liu and Zheyu Shen and Shipeng Ning}, doi = {10.1002/advs.202410432}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410432}, shortjournal = {Adv. Sci.}, title = {A turbo-charging system-like contrast agent for MRI-guided STING pathway-activated cancer immunotherapy}, volume = {12}, year = {2025}, }
• (2025). Porous single-crystal nitrides for enhanced pseudocapacitance and stability in energy storage applications. ADVS, 12(1), 2410429. (www)

  @article{ , abstract = {Supercapacitors have emerged as a prominent area of research in energy storage technology, primarily because of their high power density and notable stability compared to batteries. However, their practical implementation is hindered by their low energy densities and insufficient long-term stability. In this study, bulk porous Nb 4 N 5 and Ta 3 N 5 single crystals with excellent pseudocapacitance and electrical conductivity are successfully prepared by solid-phase transformation method. These monolithic porous single crystals (PSC) exhibit a long-range ordered crystalline architecture and substantial specific surface area, which facilitate rapid charge transport and ion diffusion within the electrolyte-permeated crystal lattice. Notably, the areal capacitance of the porous Nb 4 N 5 single crystals is 12.9 F cm −2 at a current density of 6 mA cm −2 and 35.08 F cm −2 at a scan rate of 1 mV s −1 . Furthermore, the energy density reached 1.79 mWh cm −2 at a power density of 20 mW cm −2 , demonstrating their high energy storage capability. Moreover, these porous Nb 4 N 5 single crystals exhibited robust capacitance retention and exceptional cycling stability, making them promising candidates for use as electrodes in energy storage applications. These results underscore the significant potential of porous metal nitride single crystals in advancing the field of capacitive energy storage.}, archive = {J_ADVS}, author = {Xiangqi Gao and Guoliang Ma and Cong Luo and Shaobo Xi and Lingting Ye and Kui Xie}, doi = {10.1002/advs.202410429}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410429}, shortjournal = {Adv. Sci.}, title = {Porous single-crystal nitrides for enhanced pseudocapacitance and stability in energy storage applications}, volume = {12}, year = {2025}, }
• (2025). Network medicine-based strategy identifies maprotiline as a repurposable drug by inhibiting PD-l1 expression via targeting SPOP in cancer. ADVS, 12(1), 2410285. (www)

  @article{ , abstract = {Immune checkpoint inhibitors (ICIs) are drugs that inhibit immune checkpoint (ICP) molecules to restore the antitumor activity of immune cells and eliminate tumor cells. Due to the limitations and certain side effects of current ICIs, such as programmed death protein-1, programmed cell death-ligand 1, and cytotoxic T lymphocyte-associated antigen 4 (CTLA4) antibodies, there is an urgent need to find new drugs with ICP inhibitory effects. In this study, a network-based computational framework called m ulti- net work algorithm-driven d rug r epositioning targeting I CP ( Mnet-DRI ) is developed to accurately repurpose novel ICIs from ≈3000 Food and Drug Administration-approved or investigational drugs. By applying Mnet-DRI to PD-L1, maprotiline (MAP), an antidepressant drug is repurposed, as a potential PD-L1 modifier for colorectal and lung cancers. Experimental validation revealed that MAP reduced PD-L1 expression by targeting E3 ubiquitin ligase speckle-type zinc finger structural protein (SPOP), and the combination of MAP and anti-CTLA4 in vivo significantly enhanced the antitumor effect, providing a new alternative for the clinical treatment of colorectal and lung cancer.}, archive = {J_ADVS}, author = {Saisai Tian and Mengting Xu and Xiangxin Geng and Jiansong Fang and Hanchen Xu and Xinying Xue and Hongmei Hu and Qing Zhang and Dianping Yu and Mengmeng Guo and Hongwei Zhang and Jinyuan Lu and Chengyang Guo and Qun Wang and Sanhong Liu and Weidong Zhang}, doi = {10.1002/advs.202410285}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2410285}, shortjournal = {Adv. Sci.}, title = {Network medicine-based strategy identifies maprotiline as a repurposable drug by inhibiting PD-l1 expression via targeting SPOP in cancer}, volume = {12}, year = {2025}, }
• (2025). Electronic structure engineering of single-atom tungsten on vacancy-enriched V3S4 nanosheets for efficient hydrogen evolution. ADVS, 12(1), 2409855. (www)

  @article{ , abstract = {Constructing single-atom catalysts (SACs) and optimizing the electronic structure between metal atoms and support interactions is deemed one of the most effective strategies for boosting the catalytic kinetics of the hydrogen evolution reaction (HER). Herein, a sulfur vacancy defect trapping strategy is developed to anchor tungsten single atoms onto ultrathin V 3 S 4 nanosheets with a high loading of 25.1 wt.%. The obtained W-V 3 S 4 catalyst exhibits a low overpotential of 54 mV at 10 mA cm −2 and excellent long-term stability in alkaline electrolytes. Density functional theory calculations reveal that the in situ anchoring of W single atoms triggers the delocalization and redistribution of electron density, which effectively accelerates water dissociation and facilitates hydrogen adsorption/desorption, thus enhancing HER activity. This work provides valuable insights into understanding highly active single-atom catalysts for large-scale hydrogen production.}, archive = {J_ADVS}, author = {Min Xi and Hua Zhang and Lingfeng Yang and Youyu Long and Yifan Zhao and Anran Chen and Qiaozhi Xiao and Tingting Liu and Xuechun Xiao and Guangzhi Hu}, doi = {10.1002/advs.202409855}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409855}, shortjournal = {Adv. Sci.}, title = {Electronic structure engineering of single-atom tungsten on vacancy-enriched V3S4 nanosheets for efficient hydrogen evolution}, volume = {12}, year = {2025}, }
• (2025). A broad-high temperature ceramic capacitor with local polymorphic heterogeneous structures. ADVS, 12(1), 2409814. (www)

  @article{ , abstract = {Crafting high-performance dielectrics tailored for pulsed power capacitors, in response to the escalating demands of practical applications, presents a formidable challenge. Herein, this work introduces a novel lineup of lead-free ceramics with local polymorphic heterogeneous structures, defined by the formula (1- x )[0.92BaTiO 3 -0.08Sr(Mg 1/2 Ti 3/4 )O 3 ]- x (Na 0.5 Bi 0.5 )TiO 3 (BT-SMT- x NBT). This innovative multi-scale synergistic strategy, spanning from the atomic to grain scale, yields materials with a giant recoverable energy density ( W rec ) of 10.1 J·cm −3 and an impressive energy efficiency ( η ) of 95.0%. The integration of linear end elements SMT can significantly mitigate the polarization hysteresis while concurrently boosting the breakdown strength, thus enhancing overall energy efficiency. Furthermore, the inclusion of NBT with high polarization serves to amplify domain size, thereby reinforcing the electric field-induced polarization. This addition also stimulates the creation of polymorphic heterostructures, where tetragonal and rhombohedral nanodomains coexist, as validated by aberration-corrected transmission electron microscopy. Notably, the BT-SMT-0.2NBT ceramics have demonstrated outstanding high-temperature energy storage capabilities, with a W rec of 7.2 J·cm −3 and an η of 92.2% at 150 °C, along with remarkable broad-temperature stability (Δ W rec , Δ η ≤ 4.0%, ≈20–150 °C). These achievements in this work propel the field toward more practical and durable solutions of energy storage dielectrics.}, archive = {J_ADVS}, author = {Binglong Zheng and Ying Lin and Haibo Yang and Hongmei Jing and Hu Nan and Yifei Wang and Fang-Zhou Yao and Minquan Wang and Qibin Yuan}, doi = {10.1002/advs.202409814}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409814}, shortjournal = {Adv. Sci.}, title = {A broad-high temperature ceramic capacitor with local polymorphic heterogeneous structures}, volume = {12}, year = {2025}, }
• (2025). Chemical pressure-induced unconventional band convergence leads to high thermoelectric performance in SnTe. ADVS, 12(1), 2409735. (www)

  @article{ , abstract = {Band convergence is considered a net benefit to thermoelectric performance as it decouples the density of states effective mass ( m d ∗ $m_{\mathrm{d}}^{\mathrm{*}}$ ) and carrier mobility ( µ ) by increasing valley degeneracy. Unlike conventional methods that typically prioritize m d ∗ $m_{\mathrm{d}}^{\mathrm{*}}$ at the expense of µ , this study theoretically demonstrates an unconventional band convergence strategy to enhance both and µ in SnTe under pressure. Density functional theory calculations reveal that increasing pressure from 0 to 5 GPa moves the Σ-band of SnTe upward, reducing the energy offset between L- and Σ-band from 0.35 to 0.2 eV while preserving the light band feature of the L-band. Consequently, a high power factor ( PF ) of 119.2 µW cm −1 K −2 at 300 K is achieved for p-type SnTe under 5 GPa. Chemical pressure also induces conduction band convergence, significantly enhancing the PF of n-type SnTe. Additionally, the interplay between pressure-induced phonon modes leads to a moderate increase in lattice thermal conductivity of SnTe below 3 GPa, which combined with the significantly enhanced PF , contributes to a large enhancement in ZT . Consequently, predicted ZT values of 2.12 at 650 K and 2.55 at 850 K are obtained for p- and n-type SnTe, respectively, showcasing substantial performance enhancements.}, archive = {J_ADVS}, author = {Hongwei Ming and Zhong-Zhen Luo and Zhigang Zou}, doi = {10.1002/advs.202409735}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409735}, shortjournal = {Adv. Sci.}, title = {Chemical pressure-induced unconventional band convergence leads to high thermoelectric performance in SnTe}, volume = {12}, year = {2025}, }
• (2025). Enhancement of single-molecule magnet properties by manipulating intramolecular dipolar interactions. ADVS, 12(1), 2409730. (www)

  @article{ , abstract = {A new single-molecule magnet (SMM) complex [K(18-crown-6)][(COT)Er( µ -Cl) 3 Er(COT)] ( Er 2 Cl 3 , COT = cyclooctatetraenide dianion) is obtained by the reaction of [(COT)Er( µ -Cl)(THF)] 2 ( Er 2 Cl 2 , THF = tetrahydrofuran) with an equivalent of KCl in the presence of 18-crown-6. The two COT-Er units in the newly formed complex are triply bridged by µ -Cl ligands, leading to the “head-to-tail” alignment of the magnetic easy axes distinctly different from the “staggered” arrangement in the precursor complex. This structural transformation has led to significantly enhanced intramolecular dipolar interactions and a reduced transverse component of the crystal fields, increasing the energy barrier from 150(8) K for Er 2 Cl 2 to 264(4) K for Er 2 Cl 3 and extending its magnetic relaxation time at 2 K by 2500 times with respect to Er 2 Cl 2 . More importantly, the blocking temperature increased from lower than 2 K for Er 2 Cl 2 to 8 K for Er 2 Cl 3 , and the magnetic hysteresis loops at 2 K changed from butterfly-shaped for Er 2 Cl 2 to open hysteresis loop with coercive force of 7 kOe for Er 2 Cl 3 . These results suggest that the properties of SMMs can be effectively tuned and improved by rationally arranging magnetic spins via molecular engineering.}, archive = {J_ADVS}, author = {Jia-Qi Huang and Qi-Wei Chen and You-Song Ding and Xiao-Fei Zhu and Bing-Wu Wang and Feng Pan and Zhiping Zheng}, doi = {10.1002/advs.202409730}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409730}, shortjournal = {Adv. Sci.}, title = {Enhancement of single-molecule magnet properties by manipulating intramolecular dipolar interactions}, volume = {12}, year = {2025}, }
• (2025). Patterned lead-free double Perovskite/Polymer fluorescent piezoelectric composite films for advanced anti-counterfeiting. ADVS, 12(1), 2409692. (www)

  @article{ , abstract = {The limitations of single fluorescent anti-counterfeiting technologies necessitate the development of more sophisticated encryption methods to protect information and data. Traditional optical anti-counterfeiting encryption techniques, which rely on light sources with varying wavelengths to identify information, are now insufficient to meet contemporary security demands due to their restricted response to a narrow range of wavelengths. In this study, the fabrication of patterned, lead-free double perovskite (DP)/poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) fluorescent piezoelectric composite films (CFs) is reported. These CFs integrate the up-conversion and down-conversion photoluminescent properties of Cs 2 Na 0.8 Ag 0.2 BiCl 6 :Yb 3+ /Er 3+ DP crystals with the piezoelectric properties of P(VDF-TrFE) film, facilitating multi-modal information protection. The fluorescent signals of different concealed information in CFs are observable under the excitation of 365 nm UV light and 980 nm infrared (IR) light. Additionally, external pressure applied at various locations on the CFs generates corresponding electrical signals, thereby providing triple-layer encryption for protected information. A multifunctional anti-counterfeiting device has been further developed by integrating patterned optical and electrical responses onto flexible CFs, achieving synergistic protection of information security in cross fields and bringing a significant advancement to the high-level anti-counterfeiting market.}, archive = {J_ADVS}, author = {Jindou Shi and Zeyu Wang and Nanxiang Jia and Minqiang Wang and Youlong Xu and Xiangming Li and Jinyou Shao}, doi = {10.1002/advs.202409692}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409692}, shortjournal = {Adv. Sci.}, title = {Patterned lead-free double Perovskite/Polymer fluorescent piezoelectric composite films for advanced anti-counterfeiting}, volume = {12}, year = {2025}, }
• (2025). Bio-inspired neuromorphic sensory systems from intelligent perception to nervetronics. ADVS, 12(1), 2409568. (www)

  @article{ , abstract = {Inspired by the extensive signal processing capabilities of the human nervous system, neuromorphic artificial sensory systems have emerged as a pivotal technology in advancing brain-like computing for applications in humanoid robotics, prosthetics, and wearable technologies. These systems mimic the functionalities of the central and peripheral nervous systems through the integration of sensory synaptic devices and neural network algorithms, enabling external stimuli to be converted into actionable electrical signals. This review delves into the intricate relationship between synaptic device technologies and neural network processing algorithms, highlighting their mutual influence on artificial intelligence capabilities. This study explores the latest advancements in artificial synaptic properties triggered by various stimuli, including optical, auditory, mechanical, and chemical inputs, and their subsequent processing through artificial neural networks for applications in image recognition and multimodal pattern recognition. The discussion extends to the emulation of biological perception via artificial synapses and concludes with future perspectives and challenges in neuromorphic system development, emphasizing the need for a deeper understanding of neural network processing to innovate and refine these complex systems.}, archive = {J_ADVS}, author = {Elvis K. Boahen and Hyukmin Kweon and Hayoung Oh and Ji Hong Kim and Hayoung Lim and Do Hwan Kim}, doi = {10.1002/advs.202409568}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409568}, shortjournal = {Adv. Sci.}, title = {Bio-inspired neuromorphic sensory systems from intelligent perception to nervetronics}, volume = {12}, year = {2025}, }
• (2025). Fabrication of long-lasting superhydrophilic anti-fogging film via rapid and simple UV process. ADVS, 12(1), 2409463. (www)

  @article{ , abstract = {Surface fogging is a common phenomenon that can result in restricted visibility, reduced light absorption, and image distortion. Although both hydrophobic and hydrophilic surfaces are effective in preventing this phenomenon, typical coatings in both have limitations, including low durability and the need for frequent reapplication. To address these issues, a highly durable anti-fogging film that lasts over five weeks, even under high moisture conditions, while maintaining a promising degree of transparency (> 60%) is developed. A novel statistical random copolymer containing superhydrophilic and photo-crosslinkable segments that can be simultaneously crosslinked and chemically bonded to various substrates via a simple ultraviolet (UV) irradiation process is synthesized. Notably, the chemical bonding between the anti-fogging coating and substrate improves not only the durability but also the resistance to external forces and environmental changes. Furthermore, this film is versatile and applicable to diverse substrates, such as car windshields, polymer films, and aluminum foil. The innovative strategy offers a simple, rapid process and durable anti-fogging performance with broad applications in the automotive industry, optical devices, and building materials.}, archive = {J_ADVS}, author = {Jae Hwan Jung and Yu Bin Kang and Chungryong Choi}, doi = {10.1002/advs.202409463}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409463}, shortjournal = {Adv. Sci.}, title = {Fabrication of long-lasting superhydrophilic anti-fogging film via rapid and simple UV process}, volume = {12}, year = {2025}, }
• (2025). Acoustofluidic tweezers integrated with droplet sensing enable multifunctional closed-loop droplet manipulation. ADVS, 12(1), 2409394. (www)

  @article{ , abstract = {Droplet manipulation technologies with surface acoustic waves attract significant attention for applications in fluid handling and bioanalysis. However, existing technologies face challenges in automation, precision, and functional integration, limiting broader applications. In this work, a highly integrated droplet-sensing acoustofluidic tweezer is developed, incorporating orthogonally arranged slanted finger interdigital transducers and a custom-designed control and detection circuit system. Using a single acoustic device, this tweezer enables switchable acoustic droplet manipulation and detection, providing multifunctional closed-loop manipulation of on-chip microliter-scale droplets. The platform takes advantage of the wideband frequency response characteristics of the transducers, along with an automated droplet detection algorithm, enabling high-precision detection of central positions, edge positions, contact diameters, and the number of droplets. With this feedback, automated closed-loop control of various droplet manipulation functions, including transportation, merging, mixing, splitting, and internal particle enrichment, is achieved for the first time on a single acoustic platform. This significantly enhances the precision, efficiency, and fault tolerance of the manipulation process. This droplet-sensing acoustofluidic tweezer provides an innovative acoustic solution for droplet manipulation technologies in fields such as fluid processing and biosensing, demonstrating significant application potential.}, archive = {J_ADVS}, author = {Mingyang Sui and Huijuan Dong and Guanyu Mu and Zhen Yang and Ye Ai and Jie Zhao}, doi = {10.1002/advs.202409394}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409394}, shortjournal = {Adv. Sci.}, title = {Acoustofluidic tweezers integrated with droplet sensing enable multifunctional closed-loop droplet manipulation}, volume = {12}, year = {2025}, }
• (2025). Two-step design rule for simultaneously high conductivity and seebeck coefficient in conjugated polymer-based thermoelectrics. ADVS, 12(1), 2409382. (www)

  @article{ , abstract = {The trade-off between enhancing conductivity (σ) through doping while concurrently observing a reduction in the Seebeck coefficient ( S ) presents a key challenge in organic thermoelectrics. Here, a two-step structural design strategy is developed, where the first step enhances the backbone planarity which enhances the conductivity by an improved ordering of conjugated polymers (CPs). The second step, which is fluorination of the backbone, improves the Seebeck coefficient by the controlled induction of energetic disorder, stemming from the fluorine's disruption of the homogeneous electrostatic potential across the CP backbone. This strategy is applied to two series of donor-acceptor (D-A) types of CPs based on the BDT donor unit and BDD and TT as acceptor units, respectively. A maximum power factor ( PF ) over 155 (142.7 ± 12.7) µW m −1 K −2 , coupled with S ≈202 (194.6 ± 7.6) µV K −1 is achieved, leading to up to 32-fold enhancement of the PF compared to the initial non-planar and non-fluorinated polymer. This study provides valuable conceptual insights for designing CPs with high conductivity and Seebeck coefficient.}, archive = {J_ADVS}, author = {Zelong Li and Wei Fu and Dorothea Scheunemann and Xiaoran Wei and Maximilian Litterst and Priya Mariam Viji and Yong Cui and Jianhui Hou and Junhui Tang and Ziqi Liang and Zehua Qu and Martijn Kemerink and Ruiqian Guo and Guangzheng Zuo}, doi = {10.1002/advs.202409382}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409382}, shortjournal = {Adv. Sci.}, title = {Two-step design rule for simultaneously high conductivity and seebeck coefficient in conjugated polymer-based thermoelectrics}, volume = {12}, year = {2025}, }
• (2025). Lipid droplet surface promotes 3D morphological evolution of non-rhomboidal cholesterol crystals. ADVS, 12(1), 2409201. (www)

  @article{ , abstract = {Cholesterol crystals, which cause inflammation and various diseases, predominantly grow in a platy, rhomboid structure on the plasma membranes but exhibit an uneven three-dimensional (3D) architecture intracellularly. Here, it is demonstrated how cholesterol crystallizes in a non-rhomboidal shape on the surface of lipid droplets and develops into 3D sheet-like agglomerates using an in vitro lipid droplet reconstitution system with stereoscopic fluorescence imaging. The findings reveal that interfacial cholesterol transport on the lipid droplet surface and unique lipid droplet components significantly influence the nucleation-and-growth dynamics of cholesterol crystals, leading to crystal growth in various polygonal shapes. Furthermore, cholesterol crystals readily agglomerate to form large, curved sheet structures on the confined, spherical surfaces of lipid droplets. This discovery enhances the understanding of the volumetric morphological growth of intracellular cholesterol crystals.}, archive = {J_ADVS}, author = {Hyun-Ro Lee and Seunghan Kang and Siyoung Q. Choi}, doi = {10.1002/advs.202409201}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409201}, shortjournal = {Adv. Sci.}, title = {Lipid droplet surface promotes 3D morphological evolution of non-rhomboidal cholesterol crystals}, volume = {12}, year = {2025}, }
• (2025). Encapsulating azolates within cationic Metal–Organic frameworks for high-energy-density materials. ADVS, 12(1), 2409093. (www)

  @article{ , abstract = {Despite the synthesis of numerous cationic metal-organic frameworks (CMOFs), their counter anions have been primarily limited to inorganic Cl − , NO 3 − , ClO 4 − , BF 4 − , and Cr 2 O 7 2− , which have weak coordination abilities. In this study, a series of new CMOFs is synthesized using azolates with strong coordination abilities as counter anions, which are exclusively employed as ligands for coordinating with metals. Owing to the unique nitrogen-rich composition of azolates, the CMOFs demonstrate significant potential as high-energy-density materials. Notably, CMOF(CuTNPO) has an exceptionally high heat of detonation of 7375 kJ kg −1 , surpassing even that of the state-of-art CL-20 (6536 kJ kg −1 ). To further validate the advantages of employing azolates as counter anions, analogues with azolates serving as ligands are also synthesized. The comparison study indicates that encapsulating azolates within the cationic frameworks confers both high energy and safety properties. X-ray data and quantum calculations indicate that their enhanced performance stems from stronger H─bonds and π–π interactions. This study introduces new roles for azolates in MOFs and expands possibilities for structural diversity and potential applications of framework materials.}, archive = {J_ADVS}, author = {Ning Ding and Chaofeng Zhao and Jichuan Zhang and Yao Du and Qi Sun and Shenghua Li and Siping Pang}, doi = {10.1002/advs.202409093}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409093}, shortjournal = {Adv. Sci.}, title = {Encapsulating azolates within cationic Metal–Organic frameworks for high-energy-density materials}, volume = {12}, year = {2025}, }
• (2025). Unconventional hexagonal close-packed high-entropy alloy surfaces synergistically accelerate alkaline hydrogen evolution. ADVS, 12(1), 2409023. (www)

  @article{ , abstract = {Accelerating the alkaline hydrogen evolution reaction (HER), which involves the slow cleavage of HO-H bonds and the adsorption/desorption of hydrogen (H*) and hydroxyl (OH*) intermediates, requires developing catalysts with optimal binding strengths for these intermediates. Here, the unconventional hexagonal close-packed (HCP) high-entropy alloy (HEA) atomic layers are prepared composed of five platinum-group metals to enhance the alkaline HER synergistically. The breakthrough is made by layer-by-layer heteroepitaxial deposition of subnanometer RuRhPdPtIr HEA layers on the HCP Ru seeds, despite the thermodynamic stability of Rh, Pd, Pt, and Ir in a face-centered cubic (FCC) structure except for Ru. The synchrotron X-ray absorption spectroscopy (XAS) confirms the atomic mixing and coordination environment of HCP RuRhPdPtIr HEA. Most importantly, they exhibit notable improvements in both electrocatalytic activity and durability for the HER in an alkaline environment, as compared to their FCC RuRhPdPtIr counterparts. Electrochemical measurements, operando XAS analysis, and density functional theory unveil that the binding strengths of H* and OH* intermediates on the active Pt and Ir sites can be weakened and strengthened to a moderate level, respectively, by mixing non-active Ru, Rh, and Pd atoms with Pt and Ir atoms within the HCP HEA with strong synergistic electronic effects.}, archive = {J_ADVS}, author = {Ting-Hsin Hu and Cheng-Yu Wu and Zong Ying He and Yi Chen and Liang-Ching Hsu and Chih-Wen Pao and Jui-Tai Lin and Chun-Wei Chang and Shang-Cheng Lin and Rachel Osmundsen and Lee Casalena and Kun Han Lin and Shan Zhou and Tung-Han Yang}, doi = {10.1002/advs.202409023}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2409023}, shortjournal = {Adv. Sci.}, title = {Unconventional hexagonal close-packed high-entropy alloy surfaces synergistically accelerate alkaline hydrogen evolution}, volume = {12}, year = {2025}, }
• (2025). Guanidine-derived polymeric nanoinhibitors target the lysosomal V-ATPase and activate AMPK pathway to ameliorate liver lipid accumulation. ADVS, 12(1), 2408906. (www)

  @article{ , abstract = {Current research efforts in polymer and nanotechnology applications are primarily focused on cargo delivery to enhance the therapeutic index, with limited attention being paid to self-molecularly targeted nanoparticles, which may also exhibit significant therapeutic potential. Long-term and anomalous lipid accumulation in the liver is a highly relevant factor contributing to liver diseases. However, the development of the reliable medications and their pharmacological mechanisms remain insufficient. Herein, a polyguanide nanoinhibitors (PGNI) depot is constructed by copolymerizing biguanide derivatives in different proportions onto prepolymers. The nanoinhibitors for their ability to ameliorate lipid accumulation in vitro and in vivo is screened, and subsequently demonstrated that covalently polymeric guanidine chains exhibit superior efficacy in ameliorating hepatic lipid accumulation via heterogeneous mechanisms compared to small-molecule guanidine. It is found that PGNIs stabilize guanidine metabolism in the liver, preferably for biosafety. More importantly, PGNI is ingested and localized in hepatocyte lysosomes and is locked to interact with vesicular adenosine triphosphatase (V-ATPase) on lysosomes, leading to the inhibition of V-ATPase and lysosomal acidification, thereby activating the AMPK pathway, reducing fatty acid synthesis, and enhancing lipolysis and fatty acid oxidation. These results imply that polymer-formed nanoparticles can serve as targeted inhibitors, offering a novel approach for therapeutic applications.}, archive = {J_ADVS}, author = {Yunfei Zhao and Ke Hu and Fangliang Wang and Lulu Zhao and Yu Su and Jun Chen and Gang Zou and Liming Yang and Li Wei and Mengjiao Deng and Yunyu He and Ping Wang and Xiong Z Ruan and Yaxi Chen and Chao Yu}, doi = {10.1002/advs.202408906}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408906}, shortjournal = {Adv. Sci.}, title = {Guanidine-derived polymeric nanoinhibitors target the lysosomal V-ATPase and activate AMPK pathway to ameliorate liver lipid accumulation}, volume = {12}, year = {2025}, }
• (2025). Intelligent screening of prostate cancer individuals using an enzyme-assisted multicolor visualization platform. ADVS, 12(1), 2408825. (www)

  @article{ , abstract = {Rapid and intelligent identification of prostate cancer (PCa) is critical for early diagnosis. Herein, a convenient, reliable, and intelligent strategy is proposed to screen PCa individuals through indirectly quantifying sarcosine (Sar), an early indicator of PCa, in clinical urine samples. Success is achieved by integrating sarcosine oxidase (SOX) as a specific recognition unit; nanozyme-assisted multicolor intelligent visualization platform as a signal reporter. With the Fe-MOFs and peroxidase, the synergetic action of SOX and response gold nanorods (Au NRs) is controlled etched to exhibit a multicolored signal. The sensor exhibits excellent linearity with Sar within 1–60 × 10 −6 m , boasting a remarkable detection limit of 0.12 × 10 −6 m . The RGB value of the display color can be directly extracted using a mobile phone camera. PCa diagnosis can be swiftly made (within 15 min) and directly by identifying two RGB colors ( R < 175 or B > 135). The enzyme-assisted multicolor intelligent visualization platform is adept at detecting minute differences in Sar concentration in urine samples between PCa patients and healthy individuals. The concept of enzyme-assisted multicolor sensing can be further expanded by modifying the type of immobilized enzymes, providing a valuable guideline for the rational design of multiple probes to measure specific biomarkers in biological samples.}, archive = {J_ADVS}, author = {Ruomei Teng and Ming Li and Zikang Chen and Jianli Lin and Yuhan Zhang and Hang Li and Zejun Yan and Dingyuan Zhang and Caiping Ding and Youju Huang}, doi = {10.1002/advs.202408825}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408825}, shortjournal = {Adv. Sci.}, title = {Intelligent screening of prostate cancer individuals using an enzyme-assisted multicolor visualization platform}, volume = {12}, year = {2025}, }
• (2025). Living therapeutics for synergistic hydrogen-photothermal cancer treatment by photosynthetic bacteria. ADVS, 12(1), 2408807. (www)

  @article{ , abstract = {Hydrogen gas (H 2 ) therapy, recognized for its inherent biosafety, holds significant promise as an anti-cancer strategy. However, the efficacy of H 2 treatment modalities is compromised by their reliance on systemic gas administration or chemical reactions generation, which suffers from low efficiency, poor targeting, and suboptimal utilization. In this study, living therapeutics are employed using photosynthetic bacteria Rhodobacter sphaeroides for in situ H 2 production combined with near-infrared (NIR) mediated photothermal therapy. Living R. sphaeroides exhibits strong absorption in the NIR spectrum, effectively converting light energy into thermal energy while concurrently generating H 2 . This dual functionality facilitates the targeted induction of tumor cell death and substantially reduces collateral damage to adjacent normal tissues. The findings reveal that integrating hydrogen therapy with photothermal effects, mediated through photosynthetic bacteria, provides a robust, dual-modality approach that enhances the overall efficacy of tumor treatments. This living therapeutic strategy not only leverages the therapeutic potential of both hydrogen and photothermal therapeutic modalities but also protects healthy tissues, marking a significant advancement in cancer therapy techniques.}, archive = {J_ADVS}, author = {Yingyi Zhang and Xiaolian Deng and Lili Xia and Jianghui Liang and Meng Chen and Xiaoling Xu and Wei Chen and Jianwei Ding and Chengjie Yu and Limei Liu and Yang Xiang and Yiliang Lin and Fangfang Duan and Wei Feng and Yu Chen and Xiang Gao}, doi = {10.1002/advs.202408807}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408807}, shortjournal = {Adv. Sci.}, title = {Living therapeutics for synergistic hydrogen-photothermal cancer treatment by photosynthetic bacteria}, volume = {12}, year = {2025}, }
• (2025). Hydrodynamic fluidic pump empowered sensitive recognition and active transport of hydrogen peroxide in 1D channels. ADVS, 12(1), 2408755. (www)

  @article{ , abstract = {Through synthetic chemistry, the development of molecular devices for the precise selective recognition and active transport of small molecules stands as one of the most ambitious objectives in extensive medical, environmental, and biological applications. The periodical channels of the metal–organic frameworks (MOFs) with excellent chemical affinity offer vast regulatory space for reaching this goal. Herein, by post-modifying fluorescent probes and ionic liquid molecules into the Zr-MOFs (NU-1000), a donor–acceptor (D-A) system within the periodical 1D channels is created to construct a hydrodynamic fluidic pump within the abundant 1D channels. Irradiation with light serves to initiate and direct fluid motion, expediting the transport of H 2 O 2 molecules to the active site, thus boosting the sensor sensitivity through gas enrichment. The rapid mass transfer, characterized by a high flow rate and intensified interaction between the D-A system and H 2 O 2 molecules, enables the detection of H 2 O 2 at concentrations as low as 20 ppb. Besides, with the aid of incident light, the pump system exhibits active transport characteristics by transporting radicals derived from H 2 O 2 against a concentration gradient, reaching a remarkable 10 th cycle. The strategy of achieving active transport of small molecules through pore modification holds promise for advancing the development of artificial bioactive channels.}, archive = {J_ADVS}, author = {Shuya Liu and Yongxian Guo and Yanjun Gong and Yanze Wei and Qiongzheng Hu and Li Yu}, doi = {10.1002/advs.202408755}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408755}, shortjournal = {Adv. Sci.}, title = {Hydrodynamic fluidic pump empowered sensitive recognition and active transport of hydrogen peroxide in 1D channels}, volume = {12}, year = {2025}, }
• (2025). High-strength, thermally stable, and processable wood Fiber/Polyamide composites for engineering structural components. ADVS, 12(1), 2408708. (www)

  @article{ , abstract = {Hybrid wood fiber/plastic composites offer a high-value-added utilization for agroforestry waste, which also providing a promising solution for reducing white pollution. However, the interface incompatibility between natural wood fibers and polymers significantly impairs the mechanical properties of the composites. Herein, a straightforward procedure is proposed to solve this problem, involving the removal of low-thermal-stability hemicellulose from wood fibers by hydrothermal pretreatment, followed by compositing with polyamide to produce hydrothermally treated wood fiber/polyamide composites (HWPACs). No chemical additives are required to improve the interface compatibility of composites, which simplifies the manufacturing process and provides environmental benefits. The effective removal of hemicellulose (78.35%) significantly increases the onset thermal degradation temperature of hydrothermally treated wood fibers (HWFs) by 27.49 °C. This prevents the generation of micro gaps during thermal processing, thereby improving the interfacial bonding strength between HWFs and polyamide. HWPACs exhibit higher mechanical strength (flexural strength 139.45 MPa) and thermal stability while maintaining a low density (1.22 g cm −3 ). Various lightweight, high-strength, and multi-shape materials can be prepared by hot pressing, injecting, and printing HWPACs, suggesting their suitability for applications in engineering structural components.}, archive = {J_ADVS}, author = {Zhengtong You and Haigang Wang and Feng Zhang and Haoyuan Zhang and Chuwen Zou and Zhifang Zhou and Yonggui Wang and Zefang Xiao and Daxin Liang and Qingwen Wang and Wentao Gan and Yanjun Xie}, doi = {10.1002/advs.202408708}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408708}, shortjournal = {Adv. Sci.}, title = {High-strength, thermally stable, and processable wood Fiber/Polyamide composites for engineering structural components}, volume = {12}, year = {2025}, }
• (2025). Recent development of fibrous hydrogels: Properties, applications and perspectives. ADVS, 12(1), 2408657. (www)

  @article{ , abstract = {Fibrous hydrogels (FGs), characterized by a 3D network structure made from prefabricated fibers, fibrils and polymeric materials, have emerged as significant materials in numerous fields. However, the challenge of balancing mechanical properties and functions hinders their further development. This article reviews the main advantages of FGs, including enhanced mechanical properties, high conductivity, high antimicrobial and anti-inflammatory properties, stimulus responsiveness, and an extracellular matrix (ECM)-like structure. It also discusses the influence of assembly methods, such as fiber cross-linking, interfacial treatments of fibers with hydrogel matrices, and supramolecular assembly, on the diverse functionalities of FGs. Furthermore, the mechanisms for improving the performance of the above five aspects are discussed, such as creating ion carrier channels for conductivity, in situ gelation of drugs to enhance antibacterial and anti-inflammatory properties, and entanglement and hydrophobic interactions between fibers, resulting in ECM-like structured FGs. In addition, this review addresses the application of FGs in sensors, dressings, and tissue scaffolds based on the synergistic effects of optimizing the performance. Finally, challenges and future applications of FGs are discussed, providing a theoretical foundation and new insights for the design and application of cutting-edge FGs.}, archive = {J_ADVS}, author = {Wen Luo and Liujiao Ren and Bin Hu and Huali Zhang and Zhe Yang and Lin Jin and Di Zhang}, doi = {10.1002/advs.202408657}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408657}, shortjournal = {Adv. Sci.}, title = {Recent development of fibrous hydrogels: Properties, applications and perspectives}, volume = {12}, year = {2025}, }
• (2025). Bioactive self-assembled nanoregulator enhances hematoma resolution and inhibits neuroinflammation in the treatment of intracerebral hemorrhage. ADVS, 12(1), 2408647. (www)

  @article{ , abstract = {Hematoma and secondary neuroinflammation continue to pose a significant challenge in the clinical treatment of intracerebral hemorrhage (ICH). This study describes a nanoregulator formed through the self-assembly of Mg 2+ and signal regulatory protein α (SIRPα) DNAzyme (SDz), aimed at enhancing hematoma resolution and inhibiting neuroinflammation in the treatment of ICH. The structure of SDz collapses in response to the acidic endo/lysosomal microenvironment of microglia, releasing Mg 2+ and the SIRPα DNAzyme. The Mg 2+ then acts as a cofactor to activate the SIRPα DNAzyme. By blocking the CD47-SIRPα signaling pathway, microglia can rapidly and effectively phagocytose red blood cells (RBCs), thereby promoting the clearance of the hematoma. Simultaneously, Mg 2+ reset the microglia to the M2 phenotype by inhibiting the MYD88/MAPK/NF-κB signaling pathway, thereby modulating the inflammatory microenvironment of ICH. This co-delivery and synergistic strategy resulted in a significant reduction in hematoma size, decreasing from 11.90 to 5.84 mm 3 , and promoted recovery from ICH with minimal systemic side effects. This simple yet highly effective nanoplatform, which involves complex synergistic mechanisms, proves to be effective for ICH therapy and holds great promise for introducing novel perspectives into clinical and translational approaches for ICH.}, archive = {J_ADVS}, author = {Wenyan Yu and Chengyuan Che and Yi Yang and Yuzhen Zhao and Junjie Liu and Aibing Chen and Jinjin Shi}, doi = {10.1002/advs.202408647}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408647}, shortjournal = {Adv. Sci.}, title = {Bioactive self-assembled nanoregulator enhances hematoma resolution and inhibits neuroinflammation in the treatment of intracerebral hemorrhage}, volume = {12}, year = {2025}, }
• (2025). Capillary skimming of floating microplastics via a water-bridged ratchet. ADVS, 12(1), 2408623. (www)

  @article{ , abstract = {Floating microplastics (MPs) have recently become a major concern in marine pollution; however, current filter-based technology is hardly effective for directly removing such MPs from the water surface because of specific mesh size and clogging issues. This paper introduces a new skimming concept for removing floating MPs utilizing capillary force mediated by the elevation of a hydrophilic ratchet at the air−water interface. MPs floating near the ratchet surface are spontaneously forced toward the ratchet with a concave water meniscus, driven by the Cheerios effect. The MPs can then be skimmed and temporarily held by the deforming concave water meniscus as the ratchet rises. Here, it is found that the stability of the water bridge plays a crucial role in skimming success because it provides capillary adhesion between the MP and the ratchet. The proposed capillary skimming method is observed to be effective across nearly all types of floating MPs, ranging in size from 1 to 4 mm, and with densities varying from 0.02 to 0.97 g cm − 3 , which is also demonstrated by a prototype of marine robot cleaner.}, archive = {J_ADVS}, author = {Seohyun Cho and Sang Jin Park and Young Jin Lee and You Jun Lee and Young A Lee and Ho-Young Kim and Seong Jin Kim and Seok Chung and Myoung-Woon Moon}, doi = {10.1002/advs.202408623}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408623}, shortjournal = {Adv. Sci.}, title = {Capillary skimming of floating microplastics via a water-bridged ratchet}, volume = {12}, year = {2025}, }
• (2025). Programmable macrophage vesicle based bionic self-adjuvanting vaccine for immunization against monkeypox virus. ADVS, 12(1), 2408608. (www)

  @article{ , abstract = {The emergence of monkeypox has become a global health threat after the COVID-19 pandemic. Due to the lack of available specifically treatment against MPV, developing an available vaccine is thus the most prospective and urgent strategy. Herein, a programmable macrophage vesicle based bionic self-adjuvanting vaccine (AM@AEvs-PB) is first developed for defending against monkeypox virus (MPV). Based on MPV-related antigen-stimulated macrophage-derived vesicles, the nanovaccine is constructed by loading the mature virion (MV)-related intracellular protein (A29L/M1R) and simultaneously modifying with the enveloped virion (EV) antigen (B6R), enabling them to effectively promote antigen presentation and enhance adaptive immune through self-adjuvant strategy. Owing to the synergistic properties of bionic vaccine coloaded MV and EV protein in defensing MPV, the activation ratio of antigen-presenting cells is nearly four times than that of single antigen in the same dose, resulting in stronger immunity in host. Notably, intramuscular injection uptake of AM@AEvs-PB demonstrated vigorous immune-protective effects in the mouse challenge attempt, offering a promising strategy for pre-clinical monkeypox vaccine development.}, archive = {J_ADVS}, author = {Weiqiang Lin and Chenguang Shen and Mengjun Li and Shengchao Ma and Chenxin Liu and Jialin Huang and Zuning Ren and Yuechao Yang and Minghai Zhao and Qiulin Xie and Shuang Guo and Wei Wang and Kaiyuan Wang and Qiang Ma and Yideng Jiang and Judun Zheng and Yuhui Liao}, doi = {10.1002/advs.202408608}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408608}, shortjournal = {Adv. Sci.}, title = {Programmable macrophage vesicle based bionic self-adjuvanting vaccine for immunization against monkeypox virus}, volume = {12}, year = {2025}, }
• (2025). 2D electrodes from functionalized graphene for rapid electrochemical gold extraction and reduction from electronic waste. ADVS, 12(1), 2408533. (www)

  @article{ , abstract = {Electronic waste (e-waste) contains substantial quantities of valuable precious metals, particularly gold (Au). However, inefficient metal recovery leads to these precious metals being discarded in landfills, causing significant water and environmental contamination. This study introduces a two-dimensional (2D) electrode with a layered graphene oxide membrane functionalized by chitosan (GO/CS). The GO/CS membrane acts as an ion-selective layer and demonstrates capabilities in the electrochemical extraction and reduction of Au ions. The multiple functional groups of GO and CS offer high cooperativity in ion extraction and reduction, achieving 95 wt.% extraction efficiency within 10 min. The simultaneous extraction and electrocatalytic reduction of Au ions within the membrane leads to the formation of ready-to-use metallic Au forms such as chips and sensors. Such an approach eliminates the processing steps required to convert extracted gold into functional products, reducing time, cost, and energy. This direct formation of usable Au components enhances the efficiency of the recovery process, making it economically viable and environmentally sustainable. The gold mining market is projected to be valued at $270 billion by 2032, with the recycling segment reaching $10.8 billion, highlighting the substantial benefits and economic potential of efficient e-waste recycling technologies.}, archive = {J_ADVS}, author = {Kou Yang and Konstantin G. Nikolaev and Xiaolai Li and Ivan Erofeev and Utkur M. Mirsaidov and Vasyl G. Kravets and Alexander N. Grigorenko and Xueqing Qiu and Shanqing Zhang and Kostya S. Novoselov and Daria V. Andreeva}, doi = {10.1002/advs.202408533}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408533}, shortjournal = {Adv. Sci.}, title = {2D electrodes from functionalized graphene for rapid electrochemical gold extraction and reduction from electronic waste}, volume = {12}, year = {2025}, }
• (2025). Injectable autocatalytic hydrogel triggers pyroptosis to stimulate anticancer immune response for preventing postoperative tumor recurrence. ADVS, 12(1), 2408415. (www)

  @article{ , abstract = {Modulating immunosuppression while eliminating residual microscopic tumors is critical for inhibiting the postoperative recurrence of triple-negative breast cancer (TNBC). Although immunotherapy has shown potential in achieving this goal, due to multiple immunosuppression and poor immunogenicity of apoptosis, a satisfactory anti-recurrence effect still faces the challenge. Herein, an injectable hydrogel-encapsulated autocatalytic copper peroxide (CP@Gel) therapeutic platform is designed and combine it with the clinical-grade DNA methyltransferase inhibitor decitabine (DAC) to effectively inhibit TNBC growth and postoperative recurrence via pyroptosis, killing residual cancer cells that bypass apoptosis resistance while also improving immunogenicity and modulating immunosuppression to achieve an intense anti-tumor immune response. Following injection of the CP@Gel, the sustained release of CP leads to the autocatalytic generation of reactive oxygen species, resulting in caspase-3 activation, and the pre-administered DAC inhibits the methylation of Gsdme to elevate the GSDME protein levels, leading to intense pyroptosis and anti-tumor immune responses. The in vivo results show a 67% elimination of local tumor recurrence via treatment with DAC+CP@Gel, suggesting the successful integration of sustained drug release with autocatalysis and epigenetic modification. The results thus suggest great potential for pyroptosis-based and injectable hydrogel-aided strategies for preventing the postoperative recurrence of TNBC.}, archive = {J_ADVS}, author = {Zhiping Rao and Yutong Zhu and Zhuang Chen and Yi Luo and Zuo Yang and Weijing Liu and Chaoqiang Qiao and Yuqiong Xia and Peng Yang and Dong-Man Ye and Zhongliang Wang}, doi = {10.1002/advs.202408415}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408415}, shortjournal = {Adv. Sci.}, title = {Injectable autocatalytic hydrogel triggers pyroptosis to stimulate anticancer immune response for preventing postoperative tumor recurrence}, volume = {12}, year = {2025}, }
• (2025). Deep learning-assisted label-free parallel cell sorting with digital microfluidics. ADVS, 12(1), 2408353. (www)

  @article{ , abstract = {Sorting specific cells from heterogeneous samples is important for research and clinical applications. In this work, a novel label-free cell sorting method is presented that integrates deep learning image recognition with microfluidic manipulation to differentiate cells based on morphology. Using an Active-Matrix Digital Microfluidics (AM-DMF) platform, the YOLOv8 object detection model ensures precise droplet classification, and the Safe Interval Path Planning algorithm manages multi-target, collision-free droplet path planning. Simulations and experiments revealed that detection model precision, concentration ratios, and sorting cycles significantly affect recovery rates and purity. With HeLa cells and polystyrene beads as samples, the method achieved 98.5% sorting precision, 96.49% purity, and an 80% recovery over three cycles. After a series of experimental validations, this method can also be used to sort HeLa cells from red blood cells, cancer cells from white blood cells (represented by HeLa and Jurkat cells), and differentiate white blood cell subtypes (represented by HL-60 cells and Jurkat cells). Cells sorted using this method can be lysed directly on chip within their hosting droplets, ensuring minimal sample loss and suitability for downstream bioanalysis. This innovative AM-DMF cell sorting technique holds significant potential to advance diagnostics, therapeutics, and fundamental research in cell biology.}, archive = {J_ADVS}, author = {Zongliang Guo and Fenggang Li and Hang Li and Menglei Zhao and Haobing Liu and Haopu Wang and Hanqi Hu and Rongxin Fu and Yao Lu and Siyi Hu and Huikai Xie and Hanbin Ma and Shuailong Zhang}, doi = {10.1002/advs.202408353}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408353}, shortjournal = {Adv. Sci.}, title = {Deep learning-assisted label-free parallel cell sorting with digital microfluidics}, volume = {12}, year = {2025}, }
• (2025). Black phosphorus tagged responsive strontium hydrogel particles for bone defect repair. ADVS, 12(1), 2408284. (www)

  @article{ , abstract = {Hydrogel-derived implants have proven value in bone tissue regeneration, and current efforts have concentrated on devising strategies for producing functional implants with desired structures and functions to improve therapeutic outcomes. Herein, a novel black phosphorus (BP) tagged responsive strontium (Sr) hydrogel particles are presented for bone defect repair. By applying microfluidic technology, Sr and carboxymethyl chitosan, and BP are integrated into poly(N-isopropyl acrylamide) (pNIPAM) hydrogel matrix to generate such microparticles called pNBCSMs. Upon exposure to near-infrared irradiation, the pNBCSMs experience volume shrinkage and provoke the extrusion of the incorporated Sr, ascribed to the photothermal conversion ability of BP and the thermosensitivity of pNIPAM. In vitro and in vivo experimental results reveal that pNBCSMs subjected to near-infrared light display superior anti-inflammatory, anti-apoptotic, bacterial inhibitory, as well as osteogenesis-promoting effects, thereby effectively improving defective cranial bone repair. These features suggest that the proposed pNBCSMs can be promising candidates for bone repair.}, archive = {J_ADVS}, author = {Zhengwei Liu and Hui Zhang and Jingjing Gan and Yuanjin Zhao and Yongxiang Wang}, doi = {10.1002/advs.202408284}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408284}, shortjournal = {Adv. Sci.}, title = {Black phosphorus tagged responsive strontium hydrogel particles for bone defect repair}, volume = {12}, year = {2025}, }
• (2025). CITMIC: Comprehensive estimation of cell infiltration in tumor microenvironment based on individualized intercellular crosstalk. ADVS, 12(1), 2408007. (www)

  @article{ , abstract = {The tumor microenvironment (TME) cells interact with each other and play a pivotal role in tumor progression and treatment response. A comprehensive characterization of cell and intercellular crosstalk in the TME is essential for understanding tumor biology and developing effective therapies. However, current cell infiltration analysis methods only partially describe the TME's cellular landscape and overlook cell-cell crosstalk. Here, this approach, CITMIC, can infer the cell infiltration of TME by simultaneously measuring 86 different cell types, constructing an individualized cell-cell crosstalk network based on functional similarities between cells, and using only gene transcription data. This is a novel approach to estimating the relative cell infiltration levels, which are shown to be superior to the current methods. The TME cell-based features generated by analyzing melanoma data are effective in predicting prognosis and treatment response. Interestingly, these features are found to be particularly effective in assessing the prognosis of high-stage patients, and this method is applied to multiple high-stage adenocarcinomas, where more significant prognostic performance is also observed. In conclusion, CITMIC offers a more comprehensive description of TME cell composition by considering cell-cell crosstalk, providing an important reference for the discovery of predictive biomarkers and the development of new therapeutic strategies.}, archive = {J_ADVS}, author = {Xilong Zhao and Jiashuo Wu and Jiyin Lai and Bingyue Pan and Miao Ji and Xiangmei Li and Yalan He and Junwei Han}, doi = {10.1002/advs.202408007}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2408007}, shortjournal = {Adv. Sci.}, title = {CITMIC: Comprehensive estimation of cell infiltration in tumor microenvironment based on individualized intercellular crosstalk}, volume = {12}, year = {2025}, }
• (2025). Recognition of a fungal effector potentiates pathogen-associated molecular pattern-triggered immunity in cotton. ADVS, 12(1), 2407787. (www)

  @article{ , abstract = {Plants are equipped with multi-layered immune systems that recognize pathogen-derived elicitors to activate immunity. Verticillium dahliae is a soil-borne fungus that infects a broad range of plants and causes devastating wilt disease. The mechanisms underlying immune recognition between plants and V. dahliae remain elusive. Here, a V. dahliae secretory protein, elicitor of plant defense gene ( VdEPD1 ), acts as an elicitor that triggers defense responses in both Nicotiana benthamiana and cotton plants is identified. Targeted gene deletion of VdEPD1 enhances V. dahliae virulence in plants. Expression of VdEPD1 triggers the accumulation of reactive oxygen species (ROS) and the activation of cell death in cotton plants. Gossypium barbadense EPD1-interacting receptor-like cytoplasmic kinase (GbEIR5A) and GbEIR5D interact with VdEPD1. Silencing of GbEIR5A/D significantly impairs VdEPD1-triggered cell death in cotton plants, indicating the contribution of GbEIR5A/D to VdEPD1-activated effector-triggered immunity (ETI). VdEPD1 stimulates the expression of GbEIR5A and GbEIR5D in cotton plants. Interestingly, cotton plants with silenced GbEIR5A/D genes exhibit compromised pathogen-associated molecular patterns (PAMPs)-triggered ROS accumulation, whereas overexpression of GbEIR5A or GbEIR5D enhances PAMP-induced ROS. These findings indicate that recognition of VdEPD1 potentiates GbEIRs to enhance cotton PAMP-triggered immunity (PTI), uncovering a cooperative interplay of PTI and ETI in cotton.}, archive = {J_ADVS}, author = {Lifan Sun and Xiangguo Li and Jiajie Zhong and Yu Wang and Baiyang Li and Ziqin Ye and Jie Zhang}, doi = {10.1002/advs.202407787}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407787}, shortjournal = {Adv. Sci.}, title = {Recognition of a fungal effector potentiates pathogen-associated molecular pattern-triggered immunity in cotton}, volume = {12}, year = {2025}, }
• (2025). Nonlinear stress-induced transformations in collagen fibrillar organization, disorder and strain mechanisms in the bone-cartilage unit. ADVS, 12(1), 2407649. (www)

  @article{ , abstract = {By developing a 3D X-ray modeling and spatially correlative imaging method for fibrous collagenous tissues, this study provides a comprehensive mapping of nanoscale deformation in the collagen fibril network across the intact bone-cartilage unit (BCU), whose healthy functioning is critical for joint function and preventing degeneration. Extracting the 3D fibril structure from 2D small-angle X-ray scattering before and during physiological compression reveals of dominant deformation modes, including crystallinity transitions, lateral fibril compression, and reorientation, which vary in a coupled, nonlinear, and correlated manner across the cartilage-bone interface. A distinct intermolecular arrangement of collagen molecules, and enhanced molecular-level disorder, is found in the cartilage (sliding) surface region. Just below, fibrils accommodate tissue strain by reorientation, which transitions molecular-level kinking or loss of crystallinity in the deep zone. Crystalline fibrils laterally shrink far more (20×) than they contract, possibly by water loss from between tropocollagen molecules. With the calcified plate acting as an anchor for surrounding tissue, a qualitative switch occurs in fibrillar deformation between the articular cartilage and calcified regions. These findings significantly advance this understanding of the complex, nonlinear ultrastructural dynamics at this critical interface, and opens avenues for developing targeted diagnostic and therapeutic strategies for musculoskeletal disorders.}, archive = {J_ADVS}, author = {Waqas Badar and Sheetal R. Inamdar and Peter Fratzl and Tim Snow and Nicholas J. Terrill and Martin M. Knight and Himadri S. Gupta}, doi = {10.1002/advs.202407649}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407649}, shortjournal = {Adv. Sci.}, title = {Nonlinear stress-induced transformations in collagen fibrillar organization, disorder and strain mechanisms in the bone-cartilage unit}, volume = {12}, year = {2025}, }
• (2025). Prussian blue-derived atomic Fe/Fe3C@N-doped c catalysts supported by carbon cloth as integrated air cathode for flexible zn-air batteries. ADVS, 12(1), 2407631. (www)

  @article{ , abstract = {The development of an integrated air cathode with superior oxygen reduction reaction (ORR) performance is fundamental to flexible zinc-air batteries (ZABs) for wearable electronics. Herein, a self-assembled metal-organic framework (MOF)-derived strategy is proposed to prepare a atomic Fe/Fe 3 C@N-doped C catalysts supported by carbon cloth (CC) catalyst for use as an air cathode of flexible ZABs. The Prussian Blue precursor, which self-assembles on the surface of the carbon cloth due to electrostatic attraction, is critical in achieving the uniform dispersion of catalysts with high density loading on carbon cloth substrates. The hollow cubic structure, N-doped carbon layer coating, and the integrated electrode design can provide more accessible active sites and facilitate a rapid electron transfer and mass transport. Density functional theory (DFT) calculation reveals that the electronic interactions between the Fe-N 4 and Fe 3 C dual active sites can optimize the adsorption-desorption behavior of oxygen intermediates formed during the ORR. Consequently, the Fe/Fe 3 C@N-doped C/CC exhibits an excellent half wave potential (E 1/2 = 0.903 V) and superior long-term cycling stability in alkaline environments. With excellent ORR performance, ZABs and flexible ZABs based on Fe/Fe 3 C@N-doped C/CC air cathode demonstrate excellent overall electrochemical performance in terms of open circuit voltage, maximum power density, flexibility, and cycling stability.}, archive = {J_ADVS}, author = {Zihan Wang and Jing Ren and Guoqiang Ling and Junjie Guo and Yongkang Lv and Rui-Peng Ren}, doi = {10.1002/advs.202407631}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407631}, shortjournal = {Adv. Sci.}, title = {Prussian blue-derived atomic Fe/Fe3C@N-doped c catalysts supported by carbon cloth as integrated air cathode for flexible zn-air batteries}, volume = {12}, year = {2025}, }
• (2025). Microbial surface confined growth strategy for the synthesis of highly loaded NiCoP nanoparticles with hollow derived carbon shells for sodium ion capture. ADVS, 12(1), 2407616. (www)

  @article{ , abstract = {NiCoP is considered to be a very promising material for sodium ion (Na + ) capturing, however, the volume expansion and poor cyclic stability of NiCoP during the storage limit its application. In response to these limitations, Finite element simulations are used to help in the rational design of the NiCoP structure. A novel microbial surface confined growth strategy is employed to synthesize highly loaded NiCoP nanoparticles (NiCoP NPs) supported on hollow derived carbon shells (NPC), constructing a stable composite structure known as NiCoP@NPC. The highly loaded and uniformly dispersed NiCoP NPs are anchored in-situ and fully exposed, enabling enhanced electron and ion transport efficiency and thereby boosting pseudocapacitance. The NPC from yeast played a crucial role in mitigating the volume expansion of NiCoP NPs, thereby enhancing the structural stability of the electrode. Consequently, NiCoP@NPC demonstrated a high Na + storage capacity of 59.70 ± 1.51 mg g −1 at 1.6 V and maintained good cycling stability, retaining over 73.3% of its capacity after 80 cycles at 1.6 V. Scanning transmission X-ray microscopy (STXM) analysis confirmed the reversible conversion reaction mechanism and the robust structure of NiCoP@NPC before and after the reaction; Density function theory (DFT) and electrochemical quartz crystal microbalance (EQCM-D) further confirmed that the structural design of NiCoP@NPC promoted electron transport, Na + adsorption as well as improved cycling stability. This study is intended to provide a new idea for the in-situ confined synthesis of metal phosphides electrodes with stable performance and structure.}, archive = {J_ADVS}, author = {Jianhua Yuan and Tianxiao Sun and Jinfeng Chen and Runhong Zhou and Jianglin Cao and Fei Yu and Liqing Li and Xiumin Zhong and Jie Ma}, doi = {10.1002/advs.202407616}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407616}, shortjournal = {Adv. Sci.}, title = {Microbial surface confined growth strategy for the synthesis of highly loaded NiCoP nanoparticles with hollow derived carbon shells for sodium ion capture}, volume = {12}, year = {2025}, }
• (2025). Octopus-inspired adhesives with switchable attachment to challenging underwater surfaces. ADVS, 12(1), 2407588. (www)

  @article{ , abstract = {Adhesives that excel in wet or underwater environments are critical for applications ranging from healthcare and underwater robotics to infrastructure repair. However, achieving strong attachment and controlled release on difficult substrates, such as those that are curved, rough, or located in diverse fluid environments, remains a major challenge. Here, an octopus-inspired adhesive with strong attachment and rapid release in challenging underwater environments is presented. Inspired by the octopus's infundibulum structure, a compliant, curved stalk, and an active deformable membrane for multi-surface adhesion are utilized. The stalk's curved shape enhances conformal contact on large-scale curvatures and increases contact stress for adaptability to small-scale roughness. These synergistic mechanisms improve contact across multiple length scales, resulting in switching ratios of over 1000 within ≈30 ms with consistent attachment strength of over 60 kPa on diverse surfaces and conditions. These adhesives are demonstrated through the robust attachment and precise manipulation of rough underwater objects.}, archive = {J_ADVS}, author = {Chanhong Lee and Austin C. Via and Aldo Heredia and Daniel A. Adjei and Michael D. Bartlett}, doi = {10.1002/advs.202407588}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407588}, shortjournal = {Adv. Sci.}, title = {Octopus-inspired adhesives with switchable attachment to challenging underwater surfaces}, volume = {12}, year = {2025}, }
• (2025). Surface planarization-epitaxial growth enables uniform 2D/3D heterojunctions for efficient and stable perovskite solar modules. ADVS, 12(1), 2407380. (www)

  @article{ , abstract = {Two-dimensional/three-dimensional (2D/3D) halide perovskite heterojunctions are widely used to improve the efficiency and stability of perovskite solar cells. However, interfacial defects between the 2D and 3D perovskites and the poor coverage of the 2D capping layer still hinder long-term stability and homogeneous charge extraction. Herein, a surface planarization strategy on 3D perovskite is developed that enables an epitaxial growth of uniform 2D/3D perovskite heterojunction via a vapor-assisted process. The homogeneous charge extraction and suppression of interfacial nonradiative recombination is achieved by forming a uniform 2D/3D interface. As a result, a stabilized power output efficiency of 25.97% is achieved by using a 3D perovskite composition with a bandgap of 1.55 eV. To demonstrate the universality of the strategy applied for different perovskites, the champion device based on a 1.57 eV bandgap 3D perovskite results in an efficiency of 25.31% with a record fill factor of 87.6%. Additionally, perovskite solar modules achieve a designated area (24.04 cm 2 ) certified efficiency of 20.75% with a high fill factor of 80.0%. Importantly, the encapsulated uniform 2D/3D modules retain 96.9% of the initial efficiency after 1246 h operational tracking under 65 °C (ISOS-L-3 protocol) and 91.1% after 862 h under the ISOS-O-1 protocol.}, archive = {J_ADVS}, author = {Dongxu Lin and Jun Fang and Sibo Li and Zhenye Zhan and Huan Li and Xin Wang and Guanshui Xie and Daozeng Wang and Nuanshan Huang and Haichen Peng and Weiguang Xie and Luis K. Ono and Yabing Qi and Longbin Qiu}, doi = {10.1002/advs.202407380}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407380}, shortjournal = {Adv. Sci.}, title = {Surface planarization-epitaxial growth enables uniform 2D/3D heterojunctions for efficient and stable perovskite solar modules}, volume = {12}, year = {2025}, }
• (2025). PD-1+CD8+ t cell-mediated hepatocyte pyroptosis promotes progression of murine autoimmune liver disease. ADVS, 12(1), 2407284. (www)

  @article{ , abstract = {The specific mechanisms underlying effector pathways in autoimmune liver disease remain enigmatic and therefore constructing appropriate murine models to investigate disease pathogenesis becomes critical. A spontaneous severe murine model of autoimmune liver disease has been previously established in dnTGFβRII Aire −/− mice, exhibiting disease phenotypes that resemble both human primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). The data suggests that auto-reactive liver-specific CD8 + T cells are the primary pathogenic cells in liver injury. In this study, these data are advanced through the use of both single-cell sequencing and extensive in vitro analysis. The results identify a specific expanded pathogenic subset of PD-1 + CD8 + T cells in the liver, exhibiting strong functional activity and cytotoxicity against target cells. Depletion of PD-1 + CD8 + T cells using CAR-T cells effectively alleviates the disease. GSDMD-mediated pyroptosis is found to be aberrantly activated in the livers of model mice, and treatment with a GSDMD-specific inhibitor significantly inhibits disease progression. In vitro experiments reveal that PD-1 + CD8 + T cells can induce the pyroptosis of hepatocytes through elevated production of granzyme B and perforin-1. These results provide a novel explanation for the cytotoxic activity of pathogenic liver PD-1 + CD8 + T cells in autoimmune liver diseases and offer potential therapeutic targets.}, archive = {J_ADVS}, author = {Jie Long and Si-Yu Yang and Zhen-Hua Bian and Hao-Xian Zhu and Min Ma and Xiao-Qing Wang and Liang Li and Weici Zhang and Ying Han and M. Eric Gershwin and Zhe-Xiong Lian and Zhi-Bin Zhao}, doi = {10.1002/advs.202407284}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407284}, shortjournal = {Adv. Sci.}, title = {PD-1+CD8+ t cell-mediated hepatocyte pyroptosis promotes progression of murine autoimmune liver disease}, volume = {12}, year = {2025}, }
• (2025). Super-enhancer-driven IRF2BP2 is activated by master transcription factors and sustains T-ALL cell growth and survival. ADVS, 12(1), 2407113. (www)

  @article{ , abstract = {Super enhancers (SEs) are large clusters of transcriptional enhancers driving the expression of genes crucial for defining cell identity. In cancer, tumor-specific SEs activate key oncogenes, leading to tumorigenesis. Identifying SE-driven oncogenes in tumors and understanding their functional mechanisms is of significant importance. In this study, a previously unreported SE region is identified in T-cell acute lymphoblastic leukemia (T-ALL) patient samples and cell lines. This SE activates the expression of interferon regulatory factor 2 binding protein 2 (IRF2BP2) and is regulated by T-ALL master transcription factors (TFs) such as ETS transcription factor ERG (ERG), E74 like ETS transcription factor 1 (ELF1), and ETS proto-oncogene 1, transcription factor (ETS1). Hematopoietic system-specific IRF2BP2 conditional knockout mice is generated and showed that IRF2BP2 has minimal impact on normal T cell development. However, in vitro and in vivo experiments demonstrated that IRF2BP2 is crucial for T-ALL cell growth and survival. Loss of IRF2BP2 affects the MYC and E2F pathways in T-ALL cells. Cleavage under targets and tagmentation (CUT&Tag) assays and immunoprecipitation revealed that IRF2BP2 cooperates with the master TFs of T-ALL cells, targeting the enhancer of the T-ALL susceptibility gene recombination activating 1 (RAG1) and modulating its expression. These findings provide new insights into the regulatory network within T-ALL cells, identifying potential new targets for therapeutic intervention.}, archive = {J_ADVS}, author = {Juanjuan Yu and Zimu Zhang and Yanling Chen and Jianwei Wang and Gen Li and Yanfang Tao and Yongping Zhang and Yang Yang and Chenyue Zhang and Tiandan Li and Jia Cheng and Tongtign Ji and Zhongling Wei and Wenjuan Wang and Fang Fang and Wei Jiang and Peipei Chu and Hongli Yin and Di Wu and Xiaolu Li and Xiaodong Wang and Jun-Jie Fan and Shaoyan Hu and Zhen-Hong Zhu and Shuiyan Wu and Jun Lu and Jian Pan}, doi = {10.1002/advs.202407113}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407113}, shortjournal = {Adv. Sci.}, title = {Super-enhancer-driven IRF2BP2 is activated by master transcription factors and sustains T-ALL cell growth and survival}, volume = {12}, year = {2025}, }
• (2025). Identification of nicotinic acetylcholine receptor for N-acetylcysteine to rescue nicotine-induced injury using beating cilia in primary tissue derived airway organoids. ADVS, 12(1), 2407054. (www)

  @article{ , abstract = {Smoking is one of the major contributors to airway injuries. N-acetylcysteine (NAC) has been proposed as a treatment or preventive measure for such injuries. However, the exact nature of the smoking-induced injury and the protective mechanism of NAC are not yet fully understood. Here, patient tissue-derived airway organoids for modeling smoking-induced injury, therapeutic investigation, and mechanism studies are developed. Airway organoids consist mainly of ciliated cells, together with basal cells, goblet cells, and myofibroblast-like cells. The organoids display apical-out and basal-in polarity and are enriched in beating cilia, which are sensitive to smoking challenge and NAC treatment. An algorithm is developed to measure ciliary beating activity by analyzing the altered beating pattern of cilia in response to nicotine challenge and NAC treatment. Nicotinic acetylcholine receptors (nAChRs) expressed by airway organoids are involved in the mechanisms of nicotine-induced injury through the nicotine-nAChR pathway. In contrast to the common understanding that NAC has an antioxidative effect that mitigates airway damage, it is elucidated that NAC binding to nicotine can abolish the binding capacity of nicotine to nAChRs and thus prevent nicotine-induced injury. This study focuses on the advances and potential of humanized organoids in understanding biological processes, mechanisms, and identifying therapeutic targets.}, archive = {J_ADVS}, author = {Yichao Zheng and Qinyong Tian and Haowei Yang and Yongde Cai and Jiaxin Zhang and Yifen Wu and Shuo Zhu and Zuocheng Qiu and Yimin Lin and Jiangquan Hong and Yi Zhang and David Dockrell and Shaohua Ma}, doi = {10.1002/advs.202407054}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2407054}, shortjournal = {Adv. Sci.}, title = {Identification of nicotinic acetylcholine receptor for N-acetylcysteine to rescue nicotine-induced injury using beating cilia in primary tissue derived airway organoids}, volume = {12}, year = {2025}, }
• (2025). Novel FRET-based biosensors for real-time monitoring of estrogen receptor dimerization and translocation dynamics in living cells. ADVS, 12(1), 2406907. (www)

  @article{ , abstract = {Estrogen receptors (ERs), comprising ER α and ER β, are crucial for regulating cell growth and differentiation via homo- and hetero-dimer formation. However, accurately detecting ER dimerization with precise spatiotemporal resolution remains a significant challenge. In this study, fluorescence resonance energy transfer-based biosensors to monitor ER dynamics in real-time, are developed and optimized. This approach involves comprehensive structural analysis, linker comparison, and the selection of optimal fluorescent protein pairs, resulting in three distinct biosensors capable of detecting all ER homo- and hetero-dimerizations within the nucleus. These biosensors are utilized to reveal interactions between ER α/β and calmodulin during dimer formation. Furthermore, by leveraging the ligand-binding domain (LBD) of ER β, ER ββ LBD biosensor is designed for real-time analysis of ER ββ homodimerization in the cytoplasm, enhancing the ability to screen ER dimerization-related drugs. Additionally, we developed a novel ER ββ translocation biosensor, which enables real-time observation of ER ββ translocation to the nucleus—a capability previously unavailable, is developed. This spatiotemporal analysis demonstrates the relevance of ER translocation in response to drug binding efficacy and extracellular matrix changes. Our biosensors offer transformative tools for studying ER dynamics, providing valuable insights for drug screening and the investigation of ER-related cellular processes.}, archive = {J_ADVS}, author = {Kiseok Han and Jung-Soo Suh and Gyuho Choi and Yoon-Kwan Jang and Sanghyun Ahn and Yerim Lee and Tae-Jin Kim}, doi = {10.1002/advs.202406907}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2406907}, shortjournal = {Adv. Sci.}, title = {Novel FRET-based biosensors for real-time monitoring of estrogen receptor dimerization and translocation dynamics in living cells}, volume = {12}, year = {2025}, }
• (2025). A neural circuit for bergamot essential oil-induced anxiolytic effects. ADVS, 12(1), 2406766. (www)

  @article{ , abstract = {Aromatic essential oils have been shown to relieve anxiety and enhance relaxation, although the neural circuits underlying these effects have remained unknown. Here, it is found that treatment with 1.0% bergamot essential oil (BEO) exerts anxiolytic-like effects through a neural circuit projecting from the anterior olfactory nucleus (AON) to the anterior cingulate cortex (ACC) in acute restraint stress model mice. Collectively, in vivo two-photon calcium imaging, viral tracing, and whole-cell patch clamp recordings show that inhalation exposure to 1.0% BEO can activate glutamatergic projections from the AON to GABAergic neurons in the ACC, which drives inhibition of local glutamatergic neurons (AON Glu →ACC GABA→Glu ). Optogenetic or chemogenetic manipulation of this pathway can recapitulate or abolish the BEO-induced anxiolytic-like behavioral effects in mice with ARS. Beyond depicting a previously unrecognized pathway involved in stress response, this study provides a circuit mechanism for the effects of BEO and suggests a potential target for anxiety treatment.}, archive = {J_ADVS}, author = {Meng-Yu Zhu and Wan-Ying Dong and Jin-Rong Guo and Ji-Ye Huang and Ping-Kai Cheng and Yumeng Yang and An Liu and Xin-Lu Yang and Xia Zhu and Zhi Zhang and Yuanyin Wang and Wenjuan Tao}, doi = {10.1002/advs.202406766}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2406766}, shortjournal = {Adv. Sci.}, title = {A neural circuit for bergamot essential oil-induced anxiolytic effects}, volume = {12}, year = {2025}, }
• (2025). Non-volatile resistive switching in nanoscaled elemental tellurium by vapor transport deposition on gold. ADVS, 12(1), 2406703. (www)

  @article{ , abstract = {Two-dimensional (2D) materials are promising for resistive switching in neuromorphic and in-memory computing, as their atomic thickness substantially improve the energetic budget of the device and circuits. However, many 2D resistive switching materials struggle with complex growth methods or limited scalability. 2D tellurium exhibits striking characteristics such as simplicity in chemistry, structure, and synthesis making it suitable for various applications. This study reports the first memristor design based on nanoscaled tellurium synthesized by vapor transport deposition (VTD) at a temperature as low as 100 °C fully compatible with back-end-of-line processing. The resistive switching behavior of tellurium nanosheets is studied by conductive atomic force microscopy, providing valuable insights into its memristive functionality, supported by microscale device measurements. Selecting gold as the substrate material enhances the memristive behavior of nanoscaled tellurium in terms of reduced values of set voltage and energy consumption. In addition, formation of conductive paths leading to resistive switching behavior on the gold substrate is driven by gold-tellurium interface reconfiguration during the VTD process as revealed by energy electron loss spectroscopy analysis. These findings reveal the potential of nanoscaled tellurium as a versatile and scalable material for neuromorphic computing and underscore the influential role of gold electrodes in enhancing its memristive performance.}, archive = {J_ADVS}, author = {Sara Ghomi and Christian Martella and Yoonseok Lee and Penny Hui-Ping Chang and Paolo Targa and Andrea Serafini and Davide Codegoni and Chiara Massetti and Sepideh Gharedaghi and Alessio Lamperti and Carlo Grazianetti and Deji Akinwande and Alessandro Molle}, doi = {10.1002/advs.202406703}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2406703}, shortjournal = {Adv. Sci.}, title = {Non-volatile resistive switching in nanoscaled elemental tellurium by vapor transport deposition on gold}, volume = {12}, year = {2025}, }
• (2025). Impaired Iron–Sulfur cluster synthesis induces mitochondrial PARthanatos in diabetic cardiomyopathy. ADVS, 12(1), 2406695. (www)

  @article{ , abstract = {Diabetic cardiomyopathy (DCM), a severe complication of diabetes, is characterized by mitochondrial dysfunction, oxidative stress, and DNA damage. Despite its severity, the intrinsic factors governing cardiomyocyte damage in DCM remain unclear. It is hypothesized that impaired iron–sulfur (Fe–S) cluster synthesis plays a crucial role in the pathogenesis of DCM. Reduced S-sulfhydration of cysteine desulfurase (NFS1) is a novel mechanism that contributes to mitochondrial dysfunction and PARthanatos in DCM. Mechanistically, hydrogen sulfide (H 2 S) supplementation restores NFS1 S-sulfhydration at cysteine 383 residue, thereby enhancing Fe–S cluster synthesis, improving mitochondrial function, increasing cardiomyocyte viability, and alleviating cardiac damage. This study provides novel insights into the interplay between Fe–S clusters, mitochondrial dysfunction, and PARthanatos, highlighting a promising therapeutic target for DCM and paving the way for potential clinical interventions to improve patient outcomes.}, archive = {J_ADVS}, author = {Mengyi Wang and Shiwu Zhang and Jinwei Tian and Fan Yang and He Chen and Shuzhi Bai and Jiaxin Kang and Kemiao Pang and Jiayi Huang and Mingjie Dong and Shiyun Dong and Zhen Tian and Shaohong Fang and Huitao Fan and Fanghao Lu and Bo Yu and Shuijie Li and Weihua Zhang}, doi = {10.1002/advs.202406695}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2406695}, shortjournal = {Adv. Sci.}, title = {Impaired Iron–Sulfur cluster synthesis induces mitochondrial PARthanatos in diabetic cardiomyopathy}, volume = {12}, year = {2025}, }
• (2025). Tertiary lymphoid structure in dental pulp: The role in combating bacterial infections. ADVS, 12(1), 2406684. (www)

  @article{ , abstract = {Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS. However, the role of TLS in immune response and the molecules that drive its formation remain uncertain. The dental pulp, includes a few immune cells surrounded by rigid mineralized tissue, and opens to the outside through the apical foramen. Owing to this special organization, the dental pulp generates a directional immune response to bacterial infection. Considering this aspect, the dental pulp is an ideal model for comprehensively studying the TLS. In the present study, single-cell RNA sequencing of healthy and inflamed human dental pulp reveals known markers of TLS, including C-C motif chemokine ligand 19 (CCL19), lysosome-associated membrane glycoprotein 3 (LAMP3), CC chemokine receptor 7 (CCR7), and CD86, present in inflamed dental pulp. Compared with the healthy pulp, types and proportions of immune cells increase, along with enhanced cellular communication. Multiple immunofluorescence staining reveals that typical TLS emerges in dental pulp with pulpitis, consistent with the high expression of CC chemokine ligand 3 (CCL3), which may be a key driver of TLS formation. Moreover, TLS is also observed in a mouse model of pulpitis. These findings collectively offer insights into the formation and function of TLS in response to infection.}, archive = {J_ADVS}, author = {Ruiqi Li and Fan Gu and Linlin Peng and Tingting Huan and Zhuo Zhou and Yaling Song and Jinmei He and Kaili Ye and Yao Sun and Tiejun Li and Miao He and Zhuan Bian and Wei Yin}, doi = {10.1002/advs.202406684}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2406684}, shortjournal = {Adv. Sci.}, title = {Tertiary lymphoid structure in dental pulp: The role in combating bacterial infections}, volume = {12}, year = {2025}, }
• (2025). Self-healing hyaluronic acid-based hydrogel with miRNA140-5p loaded MON-PEI nanoparticles for chondrocyte regeneration: Schiff base self-assembly approach. ADVS, 12(1), 2406479. (www)

  @article{ , abstract = {Articular cartilage defects present a significant therapeutic challenge due to the inherent avascular and aneural characteristics of cartilage tissue. Gene therapy has emerged as a promising strategy for cartilage regeneration, particularly through the use of functional RNA and biomaterial-assisted frameworks. In this study, an innovative gene-activated self-healing hydrogel is developed and fabricated for the controlled release of miR140-5p, a key regulator of cartilage regeneration. The hydrogel, crosslinked via UV radiation, is composed of aminated hyaluronic acid and a modified photosensitizer (NB). To enhance the scaffold's structural integrity and gene delivery efficiency, mineralized silk fibroin and miR140-5p-loaded MON-PEI nanoparticles are incorporated. These findings demonstrate that this novel hydrogel (miR140-5p-CaP@mSF-HA-NB) effectively encapsulates and releases miR140-5p, exhibits excellent biocompatibility, and promotes enhanced cartilage regeneration in both in vitro and in vivo models. Therefore, this gene-activated hydrogel holds significant potential for clinical applications in the treatment of articular cartilage defects.}, archive = {J_ADVS}, author = {Wei Zhu and Han Wang and Bin Feng and Guangli Liu and Yixin Bian and Tianhao Zhao and Qi Wang and Xisheng Weng}, doi = {10.1002/advs.202406479}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2406479}, shortjournal = {Adv. Sci.}, title = {Self-healing hyaluronic acid-based hydrogel with miRNA140-5p loaded MON-PEI nanoparticles for chondrocyte regeneration: Schiff base self-assembly approach}, volume = {12}, year = {2025}, }
• (2025). Massively parallel screening of Toll/Interleukin-1 receptor (TIR)-derived peptides reveals multiple toll-like receptors (TLRs)-targeting immunomodulatory peptides. ADVS, 12(1), 2406018. (www)

  @article{ , abstract = {Toll-like receptors (TLRs) are critical regulators of the immune system, and altered TLR responses lead to a variety of inflammatory diseases. Interference of intracellular TLR signaling, which is mediated by multiple Toll/interleukin-1 receptor (TIR) domains on all TLRs and TLR adapters, is an effective therapeutic strategy against immune dysregulation. Peptides that inhibit TIR-TIR interactions by fragmenting interface residues have potential as therapeutic decoys. However, a systematic method for discovering TIR-targeting moieties has been elusive, limiting exploration of the vast, unsequenced space of the TIR domain family. A comprehensive parallel screening method is developed to uncover novel TIR-binding peptides derived from previously unexplored surfaces on a wide range of TIR domains. A large peptide library is constructed, named TIR surfacesome, by tiling surface sequences of the large TIR domain family and screening against MAL TIR and MyD88 TIR , TIRs of two major TLR adaptor proteins, resulting in the discovery of hundreds of TIR-binding peptides. The selected peptides inhibited TLR signaling and demonstrated anti-inflammatory effects in macrophages, and therapeutic potential in mouse inflammatory models. This approach may facilitate the development of TLR-targeted therapeutics.}, archive = {J_ADVS}, author = {Yun Lim and Tae Kyeom Kang and Meong Il Kim and Dohyeon Kim and Ji Yul Kim and Sang Hoon Jung and Keunwan Park and Wook-Bin Lee and Moon-Hyeong Seo}, doi = {10.1002/advs.202406018}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2406018}, shortjournal = {Adv. Sci.}, title = {Massively parallel screening of Toll/Interleukin-1 receptor (TIR)-derived peptides reveals multiple toll-like receptors (TLRs)-targeting immunomodulatory peptides}, volume = {12}, year = {2025}, }
• (2025). Identifying multiomic signatures of X-linked retinoschisis-derived retinal organoids and mice harboring patient-specific mutation using spatiotemporal single-cell transcriptomics. ADVS, 12(1), 2405818. (www)

  @article{ , abstract = {X-linked retinoschisis (XLRS) is an inherited retinal disorder with severe retinoschisis and visual impairments. Multiomics approaches integrate single-cell RNA-sequencing (scRNA-seq) and spatiotemporal transcriptomics (ST) offering potential for dissecting transcriptional networks and revealing cell-cell interactions involved in biomolecular pathomechanisms. Herein, a multimodal approach is demonstrated combining high-throughput scRNA-seq and ST to elucidate XLRS-specific transcriptomic signatures in two XLRS-like models with retinal splitting phenotypes, including genetically engineered ( Rs1 emR209C ) mice and patient-derived retinal organoids harboring the same patient-specific p.R209C mutation. Through multiomics transcriptomic analysis, the endoplasmic reticulum (ER) stress/eukryotic initiation factor 2 (eIF2) signaling, mTOR pathway, and the regulation of eIF4 and p70S6K pathways are identified as chronically enriched and highly conserved disease pathways between two XLRS-like models. Western blots and proteomics analysis validate the occurrence of unfolded protein responses, chronic eIF2α signaling activation, and chronic ER stress-induced apoptosis. Furthermore, therapeutic targeting of the chronic ER stress/eIF2α pathway activation synergistically enhances the efficacy of AAV-mediated RS1 gene delivery, ultimately improving bipolar cell integrity, postsynaptic transmission, disorganized retinal architecture, and electrophysiological responses. Collectively, the complex transcriptomic signatures obtained from Rs1 emR209C mice and patient-derived retinal organoids using the multiomics approach provide opportunities to unravel potential therapeutic targets for incurable retinal diseases, such as XLRS.}, archive = {J_ADVS}, author = {Yueh Chien and You-Ren Wu and Chih-Ying Chen and Yi-Ping Yang and Lo-Jei Ching and Bo-Xuan Wang and Wei-Chao Chang and I-Hsun Chiang and Pong Su and Shih-Yu Chen and Wen-Chang Lin and I-Chieh Wang and Tai-Chi Lin and Shih-Jen Chen and Shih-Hwa Chiou}, doi = {10.1002/advs.202405818}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2405818}, shortjournal = {Adv. Sci.}, title = {Identifying multiomic signatures of X-linked retinoschisis-derived retinal organoids and mice harboring patient-specific mutation using spatiotemporal single-cell transcriptomics}, volume = {12}, year = {2025}, }
• (2025). A cardiac-targeting and anchoring bimetallic cluster nanozyme alleviates chemotherapy-induced cardiac ferroptosis and PANoptosis. ADVS, 12(1), 2405597. (www)

  @article{ , abstract = {Doxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse effects on cardiac function. Previous research has demonstrated a strong correlation between DOX-induced cardiotoxicity and the activation of oxidative stress pathways. This work introduces a novel antioxidant therapeutic approach, utilizing libraries of tannic acid and N-acetyl-L-cysteine-protected bimetallic cluster nanozymes. Through extensive screening for antioxidative enzyme-like activity, an optimal bimetallic nanozyme (AuRu) is identified that possess remarkable antioxidant characteristics, mimicking catalase-like enzymes. Theoretical calculations reveal the surface interactions of the prepared nanozymes that simulate the hydrogen peroxide decomposition process, showing that these bimetallic nanozymes readily undergo OH⁻ adsorption and O₂ desorption. To enhance cardiac targeting, the atrial natriuretic peptide is conjugated to the AuRu nanozyme. These cardiac-targeted bimetallic cluster nanozymes, with their anchoring capability, effectively reduce DOX-induced cardiomyocyte ferroptosis and PANoptosis without compromising tumor treatment efficacy. Thus, the therapeutic approach demonstrates significant reductions in chemotherapy-induced cardiac cell death and improvements in cardiac function, accompanied by exceptional in vivo biocompatibility and stability. This study presents a promising avenue for preventing chemotherapy-induced cardiotoxicity, offering potential clinical benefits for cancer patients.}, archive = {J_ADVS}, author = {Junyue Xing and Xiaohan Ma and Yanan Yu and Yangfan Xiao and Lu Chen and Weining Yuan and Yingying Wang and Keyu Liu and Zhiping Guo and Hao Tang and Kelong Fan and Wei Jiang}, doi = {10.1002/advs.202405597}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2405597}, shortjournal = {Adv. Sci.}, title = {A cardiac-targeting and anchoring bimetallic cluster nanozyme alleviates chemotherapy-induced cardiac ferroptosis and PANoptosis}, volume = {12}, year = {2025}, }
• (2025). PcWRKY1 represses transcription of yellow stripe-like 3 (PcYSL3) to negatively regulate radial cadmium transport in poplar stems. ADVS, 12(1), 2405492. (www)

  @article{ , abstract = {A considerable amount of cadmium (Cd) can accumulate in the bark of poplar stems, but the Cd transport pathway and its underlying molecular mechanisms remain unknown. Here, a Cd radial transport pathway in poplar stems and a previously unrecognized PcWRKY1- Yellow Stripe-Like 3 ( PcYSL3 ) module that regulates Cd transport are identified in Populus × canescens (Aiton) Sm. Cadmiun-nicotianamine (Cd-NA) in xylem vessels in poplar stem-wood is unloaded to adjacent ray parenchyma cells and further radially transported to bark-phloem. PcYSL3 is putatively identified as involved in Cd radial transport in poplar stems. PcYSL3 is highly expressed in ray parenchyma cells adjacent to xylem vessels and the encoded protein localizes on the plasma membrane. Cd accumulation is greater in the wood and bark of PcYSL3 -overexpressing poplars than the wild type, whereas the opposite is observed in PcYSL3 -knockdown plants. PcWRKY1 can bind to the PcYSL3 promoter sequence and represses its expression. PcWRKY1 inhibits Cd accumulation in the wood and bark of plants. Thus, PcWRKY1 suppresses PcYSL3 transcription to negatively regulate Cd-NA unloading from xylem vessels to adjacent ray parenchyma cells and its radial transport in poplar stem. The findings have provided new insights into breeding of poplars for more effective remediation of heavy metal-contaminated soils.}, archive = {J_ADVS}, author = {Xin Chen and Yuhong Zhang and Yao Cheng and Wenjian Yu and Lingyu Yang and Peiqi Shu and Jing Zhou and Payam Fayyaz and Zhi-Bin Luo and Shurong Deng and Wenguang Shi}, doi = {10.1002/advs.202405492}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2405492}, shortjournal = {Adv. Sci.}, title = {PcWRKY1 represses transcription of yellow stripe-like 3 (PcYSL3) to negatively regulate radial cadmium transport in poplar stems}, volume = {12}, year = {2025}, }
• (2025). Ultra-low threshold resonance switching by terahertz field enhancement-induced nanobridge. ADVS, 12(1), 2405225. (www)

  @article{ , abstract = {Ongoing efforts spanning decades aim to enhance the efficiency of optical devices, highlighting the need for a pioneering approach in the development of next-generation components over a broad range of electromagnetic wave spectra. The nonlinear transport of photoexcited carriers in semiconductors at low photon energies is crucial to advancements in semiconductor technology, communication, sensing, and various other fields. In this study, ultra-low threshold resonance mode switching by strong nonlinear carrier transport beyond the semi-classical Boltzmann transport regime using terahertz (THz) electromagnetic waves are demonstrated, whose energy is thousands of times smaller than the bandgap. This is achieved by employing elaborately fabricated 3D tip structures at the nanoscale, and nonlinear effects are directly observed with the THz resonance mode switching. The nanotip structure intensively localizes the THz field and amplifies it by more than ten thousand times, leading to the first observation of carrier multiplication phenomena in these low-intensity THz fields. This experimental findings, confirmed by concrete calculations, shed light on the newly discovered nonlinear behavior of THz fields and their strong interactions with nanoscale structures, with potential implications and insights for advanced THz technologies beyond the quantum regime.}, archive = {J_ADVS}, author = {Sang-Hun Lee and Moohyuk Kim and Yeeun Roh and Myung-Ki Kim and Minah Seo}, doi = {10.1002/advs.202405225}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2405225}, shortjournal = {Adv. Sci.}, title = {Ultra-low threshold resonance switching by terahertz field enhancement-induced nanobridge}, volume = {12}, year = {2025}, }
• (2025). Bi-stable metamaterials with intrinsic memory for selective wave filtering based on frequency and amplitude. ADVS, 12(1), 2405146. (www)

  @article{ , abstract = {Analytical, numerical, and experimental methods are used to investigate the utility of metamaterials in controlling harmonic waves based on both their amplitude and frequency. By programming the metamaterials to support bi-stable configurations (i.e., two stable phases), the required conditions are elucidated for a transition wave (i.e., a topological soliton) to nucleate due to harmonic excitation, causing a phase change within our metamaterial. As each of these phases has its own unique transmission frequency range, such phase change is harnessed to control harmonic waves based on both their amplitude and frequency. As a demonstration of principle, a low/high-pass filter is shown by tuning the same metamaterial to change phase; from transmission to attenuation and vice versa. In addition, phase transitions taking place while preserving the metamaterial's state of attenuation or transmission are shown. Such materials can continue their functionality (i.e., either attenuation or transmission of waves) while keeping a record of extreme events that can cause their transition (i.e., have memory). These metamaterials can be useful in the next generations of advanced and functional acoustic devices.}, archive = {J_ADVS}, author = {Nathan N. Stenseng and Mahmoud M. Samak and Osama R. Bilal}, doi = {10.1002/advs.202405146}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2405146}, shortjournal = {Adv. Sci.}, title = {Bi-stable metamaterials with intrinsic memory for selective wave filtering based on frequency and amplitude}, volume = {12}, year = {2025}, }
• (2025). STAMBPL1/TRIM21 balances AXL stability impacting mesenchymal phenotype and immune response in KIRC. ADVS, 12(1), 2405083. (www)

  @article{ , abstract = {Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy is incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial-to-mesenchymal transition (EMT) is associated with immune evasion and can contribute to immunotherapy resistance. Here, the involvement of STAM Binding Protein Like 1 (STAMBPL1) is reported in the development of mesenchymal and immune evasion phenotypes in KIRC cells. Mechanistically, STAMBPL1 elevated protein abundance and surface accumulation of TAM Receptor AXL through diminishing the TRIM21-mediated K63-linked ubiquitination and subsequent lysosomal degradation of AXL, thereby enhancing the expression of mesenchymal genes while suppressing chemokines CXCL9/10 and HLA/B/C. In addition, STAMBPL1 enhanced PD-L1 transcription via facilitating nuclear translocation of p65, and knockdown (KD) of STAMBPL1 augmented antitumor effects of PD-1 blockade. Furthermore, STAMBPL1 silencing and the tyrosine kinase inhibitor (TKI) sunitinib also exhibited a synergistic effect on the suppression of KIRC. Collectively, targeting the STAMBPL1/TRIM21/AXL axis can decrease mesenchymal phenotype and potentiate anti-tumor efficacy of cancer therapy.}, archive = {J_ADVS}, author = {Shiyu Huang and Xuke Qin and Shujie Fu and Juncheng Hu and Zhengyu Jiang and Min Hu and Banghua Zhang and Jiachen Liu and Yujie Chen and Minghui Wang and Xiuheng Liu and Zhiyuan Chen and Lei Wang}, doi = {10.1002/advs.202405083}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2405083}, shortjournal = {Adv. Sci.}, title = {STAMBPL1/TRIM21 balances AXL stability impacting mesenchymal phenotype and immune response in KIRC}, volume = {12}, year = {2025}, }
• (2025). Noninvasive immunotyping and immunotherapy monitoring of lung cancers via nuclear imaging of LAG-3 and PD-l1. ADVS, 12(1), 2404231. (www)

  @article{ , abstract = {Immunotherapy has significantly improved cancer patient survival, while its efficacy remains limited due to the reliance on a single marker like PD-L1 as well as its spatiotemporal heterogeneity. To address this issue, combining lymphocyte activation gene-3 (LAG-3) with PD-L1 is proposed for identifying immunotypes and monitoring immunotherapy through nuclear imaging. In short, 99m Tc-HYNIC-αLAG-3 and 99m Tc-HYNIC-αPD-L1 probes are synthesized using anti-human LAG-3 and PD-L1 antibodies, respectively. With high radiochemical purity and in vitro stability, these probes are confirmed to specifically bind to LAG-3 or PD-L1 in LAG3 + A549, LAG3 − A549, and H1975 cells. SPECT/CT imaging of both probes showed specific in vivo tumor uptake in multiple lung cancer models, with significant linear correlation with ex vivo tumor uptake and immunohistochemical expression levels of LAG-3/PD-L1. Based on this, dual-index imaging was performed to simultaneously quantify LAG-3 and PD-L1. SPECT/CT imaging of 99m Tc-HYNIC-αLAG-3 and 125 I-αPD-L1 successfully distinguished four immunotypes. In addition, SPECT/CT imaging revealed LAG-3 upregulation in LLC-bearing LAG-3 humanized mice resistant to immunotherapy. In conclusion, this study demonstrates the feasibility of nuclear imaging of LAG-3 and PD-L1 for both noninvasive immunotyping and immunotherapy monitoring, thus offering novel perspectives on forecasting immunotherapy response, uncovering resistance mechanism, and optimizing combination treatment regimens.}, archive = {J_ADVS}, author = {Lishu Zhao and Jianxian Ge and Ruru Zhang and Hao Wang and Xinyue Liu and Kandi Xu and Yujin Liu and Wencheng Zhao and Wengang Zhang and Li Ye and Zhimin Chen and Jianfeng Zeng and Yayi He and Mingyuan Gao}, doi = {10.1002/advs.202404231}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2404231}, shortjournal = {Adv. Sci.}, title = {Noninvasive immunotyping and immunotherapy monitoring of lung cancers via nuclear imaging of LAG-3 and PD-l1}, volume = {12}, year = {2025}, }
• (2025). Targeting ATAD3A phosphorylation mediated by TBK1 ameliorates senescence-associated pathologies. ADVS, 12(1), 2404109. (www)

  @article{ , abstract = {Targeting cellular senescence, one of the hallmarks of aging and aging-related pathologies emerges as an effective strategy for anti-aging and cancer chemotherapy. Here, a switch from TBK1-OPTN axis to TBK1-ATAD3A axis to promote cellular senescence is shown. Mechanically, TBK1 protein is abnormally activated and localized to the mitochondria during senescence, which directly phosphorylates ATAD3A at Ser321. Phosphorylated ATAD3A is significantly elevated in cellular senescence as well as in physiological and pathological aging and is essential for suppressing Pink1-mediated mitophagy by facilitating Pink1 mitochondrial import. Inhibition of ATAD3A phosphorylation at Ser321 by either TBK1 deficiency or by a Ser321A mutation rescues the cellular senescence. A blocking peptide, TAT-PEP, specifically abrogating ATAD3A phosphorylation, results in elevated cell death by preventing doxorubicin-induced senescence, thus leading to enhanced tumor sensitivity to chemotherapy. TAT-PEP treatment also ameliorates various phenotypes associated with physiological aging. Collectively, these results reveal the TBK1-ATAD3A-Pink1 axis as a driving force in cellular senescence and suggest a potential mitochondrial target for anti-aging therapy.}, archive = {J_ADVS}, author = {Yujiao He and Yanchen Liu and Mingyue Zheng and Yuxiu Zou and Mujie Huang and Linsheng Wang and Ge Gao and Zhongjun Zhou and Guoxiang Jin}, doi = {10.1002/advs.202404109}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2404109}, shortjournal = {Adv. Sci.}, title = {Targeting ATAD3A phosphorylation mediated by TBK1 ameliorates senescence-associated pathologies}, volume = {12}, year = {2025}, }
• (2025). CircFndc3b mediates exercise-induced neuroprotection by mitigating Microglial/Macrophage pyroptosis via the ENO1/KLF2 axis in stroke mice. ADVS, 12(1), 2403818. (www)

  @article{ , abstract = {Circular RNA (circRNA) plays a pivotal role in regulating neurological damage post-ischemic stroke. Previous researches demonstrated that exercise mitigates neurological dysfunction after ischemic stroke, yet the specific contributions of circRNAs to exercise-induced neuroprotection remain unclear. This study reveals that mmu_circ_0001113 (circFndc3b) is markedly downregulated in the penumbral cortex of a mouse model subjected to middle cerebral artery occlusion (MCAO). However, exercise increased circFndc3b expression in microglia/macrophages, alleviating pyroptosis, reducing infarct volume, and enhancing neurological recovery in MCAO mice. Mechanistically, circFndc3b interacted with Enolase 1 (ENO1), facilitating ENO1's binding to the 3' Untranslated Region (3'UTR) of Krüppel-like Factor 2 (Klf2) mRNA, thereby stabilizing Klf2 mRNA and increasing its protein expression, which suppressed NOD-like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome-mediated microglial/macrophage pyroptosis. Additionally, circFndc3b enhanced ENO1's interaction with the 3′UTR of Fused in Sarcoma (FUS) mRNA, leading to increased FUS protein levels and promoting circFndc3b cyclization. These results suggest that circFndc3b mediates exercise-induced anti-pyroptotic effects via the ENO1/Klf2 axis, and a circFndc3b/ENO1/FUS positive feedback loop may potentiate exercise's neuroprotective effects. This study unveils a novel mechanism underlying exercise-induced neuroprotection in ischemic stroke and positions circFndc3b as a promising therapeutic target for stroke management, mimicking the beneficial effects of exercise.}, archive = {J_ADVS}, author = {Yun Zhao and Xiaofei He and Xiaofeng Yang and Zhongqiu Hong and Yin Xu and Jinghui Xu and Haiqing Zheng and Liying Zhang and Zejie Zuo and Xiquan Hu}, doi = {10.1002/advs.202403818}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2403818}, shortjournal = {Adv. Sci.}, title = {CircFndc3b mediates exercise-induced neuroprotection by mitigating Microglial/Macrophage pyroptosis via the ENO1/KLF2 axis in stroke mice}, volume = {12}, year = {2025}, }
• (2025). An EED/PRC2-h19 loop regulates cerebellar development. ADVS, 12(1), 2403591. (www)

  @article{ , abstract = {EED (embryonic ectoderm development) is a core subunit of the polycomb repressive complex 2 (PRC2), which senses the trimethylation of histone H3 lysine 27 (H3K27). However, its biological function in cerebellar development remains unknown. Here, we show that EED deletion from neural stem cells (NSCs) or cerebellar granule cell progenitors (GCPs) leads to reduced GCPs proliferation, cell death, cerebellar hypoplasia, and motor deficits in mice. Joint profiling of transcripts and ChIP-seq analysis in cerebellar granule cells reveals that EED regulates bunches of genes involved in cerebellar development. EED ablation exhibits overactivation of a developmental repressor long non-coding RNA H19. Importantly, an obvious H3K27ac enrichment is found at Ctcf , a trans-activator of H19, and H3K27me3 enrichment at the H19 imprinting control region (ICR), suggesting that EED regulates H19 in an H3K27me3-dependent manner. Intriguingly, H19 deletion reduces EED expression and the reprogramming of EED-mediated H3K27me3 profiles, resulting in increased proliferation, differentiation, and decreased apoptosis of GCPs. Finally, molecular and genetic evidence provides that increased H19 expression is responsible for cerebellar hypoplasia and motor defects in EED mutant mice. Thus, this study demonstrates that EED, H19 forms a negative feedback loop, which plays a crucial role in cerebellar morphogenesis and controls cerebellar development.}, archive = {J_ADVS}, author = {Pei-Pei Liu and Xiao Han and Xiao Li and Shang-Kun Dai and Ya-Jie Xu and Lin-Fei Jiao and Hong-Zhen Du and Li-Hua Zhao and Rong-Feng Li and Zhao-Qian Teng and Yun-Gui Yang and Chang-Mei Liu}, doi = {10.1002/advs.202403591}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2403591}, shortjournal = {Adv. Sci.}, title = {An EED/PRC2-h19 loop regulates cerebellar development}, volume = {12}, year = {2025}, }
• (2025). Humoral immunity profiling to pandemic and bat-derived coronavirus variants: A geographical comparison. ADVS, 12(1), 2403503. (www)

  @article{ , abstract = {Dynamic pathogen exposure may impact the immunological response to SARS-CoV-2 (SCV2). One potential explanation for the lack of severe SCV2-related morbidity and mortality in Southeast Asia is prior exposure to related betacoronaviruses. Recent discoveries of SCV2-related betacoronaviruses from horseshoe bats ( Rhinolophus sinicus ) in Thailand, Laos, and Cambodia suggest the potential for bat-to-human spillover exposures in the region. In this work, serum antibodies to protein constructs from SCV2 and a representative bat coronavirus isolated in Cambodia (RshSTT182) are measured in pre-pandemic Cambodian human sera using ELISA assays. Of 293 Cambodian samples tested ( N = 131 with acute malaria, n = 162 with acute undifferentiated febrile illness), 32 (10.9%) are seropositive for SCV2 based on established Spike and receptor-binding domain (RBD) cutoffs. Within SCV2 seropositive samples, 16 (50%) have higher antibody levels to antigens from the representative virus RshSTT182 versus SCV2 antigens; competitive binding ELISA assays demonstrate inhibition of reactivity to SCV2 Spike after pre-incubation with RshSTT182 Spike. Surrogate virus neutralization tests demonstrate that 8/30 (26.7%) SCV2 ELISA positive pre-pandemic Cambodian samples have neutralizing activity against SCV2, while 14/30 (46.7%) have activity against other SCV2-related betacoronaviruses. These data suggest that exposure to related betacoronaviruses may elicit cross-reactive immunity to SCV2 prior to the global pandemic.}, archive = {J_ADVS}, author = {Parinaz Fathi and Andrea Lucia Alfonso and Christina Yek and Zoe Putman and Matthew Drew and Dominic Esposito and Irfan Zaidi and Sophana Chea and Sokna Ly and Rathanak Sath and Chanthap Lon and Huch Chea and Rithea Leang and Rekol Huy and Sovann Ly and Heng Seng and Chee Wah Tan and Feng Zhu and Lin-Fa Wang and Fabiano Oliveira and Kaitlyn Sadtler and Jessica Manning}, doi = {10.1002/advs.202403503}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2403503}, shortjournal = {Adv. Sci.}, title = {Humoral immunity profiling to pandemic and bat-derived coronavirus variants: A geographical comparison}, volume = {12}, year = {2025}, }
• (2025). Mapping nanoscale-to-single-cell phosphoproteomic landscape by chip-DIA. ADVS, 12(1), 2402421. (www)

  @article{ , abstract = {Protein phosphorylation plays a crucial role in regulating disease phenotypes and serves as a key target for drug development. Mapping nanoscale-to-single-cell samples can unravel the heterogeneity of cellular signaling events. However, it remains a formidable analytical challenge due to the low detectability, abundance, and stoichiometry of phosphorylation sites. Here, we present a Chip-DIA strategy, integrating a microfluidic-based phosphoproteomic chip (iPhosChip) with data-independent acquisition mass spectrometry (DIA-MS) for ultrasensitive nanoscale-to-single-cell phosphoproteomic profiling. The iPhosChip operates as an all-in-one station that accommodates both quantifiable cell capture/imaging and the entire phosphoproteomic workflow in a highly streamlined and multiplexed manner. Coupled with a sample size-comparable library-based DIA-MS strategy, Chip-DIA achieved ultra-high sensitivity, detecting 1076±158 to 15869±1898 phosphopeptides from 10±0 to 1013±4 cells, and revealed the first single-cell phosphoproteomic landscape comprising druggable sites and basal phosphorylation-mediated networks in lung cancer. Notably, the sensitivity and coverage enabled the illumination of heterogeneous cytoskeleton remodeling and cytokeratin signatures in patient-derived cells resistant to third-generation EGFR therapy, stratifying mixed-lineage adenocarcinoma-squamous cell carcinoma subtypes, and identifying alternative targeted therapy for late-stage patients. With flexibility in module design and functionalization, Chip-DIA can be adapted to other PTM-omics to explore dysregulated PTM landscapes, thereby guiding therapeutic strategies toward precision oncology.}, archive = {J_ADVS}, author = {Gul Muneer and Sofani Tafesse Gebreyesus and Ciao-Syuan Chen and Tzu-Tsung Lee and Fengchao Yu and Chih-An Lin and Min-Shu Hsieh and Alexey I. Nesvizhskii and Chao-Chi Ho and Sung-Liang Yu and Hsiung-Lin Tu and Yu-Ju Chen}, doi = {10.1002/advs.202402421}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2402421}, shortjournal = {Adv. Sci.}, title = {Mapping nanoscale-to-single-cell phosphoproteomic landscape by chip-DIA}, volume = {12}, year = {2025}, }
• (2025). Exploring the frontiers of cell temperature measurement and thermogenesis. ADVS, 12(1), 2402135. (www)

  @article{ , abstract = {The precise measurement of cell temperature and an in-depth understanding of thermogenic processes are critical in unraveling the complexities of cellular metabolism and its implications for health and disease. This review focuses on the mechanisms of local temperature generation within cells and the array of methods developed for accurate temperature assessment. The contact and noncontact techniques are introduced, including infrared thermography, fluorescence thermometry, and other innovative approaches to localized temperature measurement. The role of thermogenesis in cellular metabolism, highlighting the integral function of temperature regulation in cellular processes, environmental adaptation, and the implications of thermogenic dysregulation in diseases such as metabolic disorders and cancer are further discussed. The challenges and limitations in this field are critically analyzed while technological advancements and future directions are proposed to overcome these barriers. This review aims to provide a consolidated resource for current methodologies, stimulate discussion on the limitations and challenges, and inspire future innovations in the study of cellular thermodynamics.}, archive = {J_ADVS}, author = {Hanliang Zhu and Haotian Xu and Yue Zhang and Jan Brodský and Imrich Gablech and Marie Korabečná and Pavel Neuzil}, doi = {10.1002/advs.202402135}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2402135}, shortjournal = {Adv. Sci.}, title = {Exploring the frontiers of cell temperature measurement and thermogenesis}, volume = {12}, year = {2025}, }
• (2025). Targeting SLITRK4 restrains proliferation and liver metastasis in colorectal cancer via regulating PI3K/AKT/NFκB pathway and tumor-associated macrophage. ADVS, 12(1), 2400367. (www)

  @article{ , abstract = {Liver metastasis is the major cause of death in colorectal cancer (CRC) due to the lack of effective treatment. To explore novel drivers of CRC liver metastasis, the transcriptomes of primary paracancerous, colorectal tumors and metastases from human patients are profiled. It is found that SLIT- and NTRK-like family member 4 (SLITRK4) is the top upregulated gene in liver metastases and is associated with worse overall survival of CRC patients. Multiple in vitro and in vivo models suggested SLITRK4 promoted CRC tumorigenesis, invasion, migration, and angiogenesis, and inhibition of it restrained CRC tumor growth and liver metastasis with a more profound effect on the tumor microenvironment (TME). Mechanistically, SLITRK4 overexpression significantly activated the PI3K/AKT/NFκB pathway, regulated extracellular matrix organization, and multiple cytokines expression. Furthermore, the results from coculture models and single-cell RNA sequencing analyses suggested SLITRK4 promoted tumor-associated macrophages (TAMs) infiltration and polarization. In addition, macrophage depletion significantly inhibited SLITRK4-induced liver metastasis in CRC. Finally, pharmacological inhibition of SLITRK4 by using lipid-polymer hybrid nanoparticles (NPs) for systemic siRNA delivery can effectively inhibit CRC liver metastasis. Taken together, these results pinpoint that SLITRK4 regulates CRC tumorigenesis and liver metastasis, and siRNA delivering NPs agents validate the therapeutic potential of targeting SLITRK4 in CRC.}, archive = {J_ADVS}, author = {Xiaojiao Sun and Junling Zhang and Bingqi Dong and Qingqing Xiong and Xin Wang and Yanlun Gu and Zhiqi Wang and Huiyu Liu and Jixin Zhang and Xu He and Hongjin Liu and Yi Zhong and Chuxiao Yi and Xiaowei Chi and Zhenming Liu and Xiaocong Pang and Yimin Cui}, doi = {10.1002/advs.202400367}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2400367}, shortjournal = {Adv. Sci.}, title = {Targeting SLITRK4 restrains proliferation and liver metastasis in colorectal cancer via regulating PI3K/AKT/NFκB pathway and tumor-associated macrophage}, volume = {12}, year = {2025}, }
• (2025). Inhibition of glutamate-to-glutathione flux promotes tumor antigen presentation in colorectal cancer cells. ADVS, 12(1), 2310308. (www)

  @article{ , abstract = {Colorectal cancer (CRC) cells display remarkable adaptability, orchestrating metabolic changes that confer growth advantages, pro-tumor microenvironment, and therapeutic resistance. One such metabolic change occurs in glutamine metabolism. Colorectal tumors with high glutaminase (GLS) expression exhibited reduced T cell infiltration and cytotoxicity, leading to poor clinical outcomes. However, depletion of GLS in CRC cells has minimal effect on tumor growth in immunocompromised mice. By contrast, remarkable inhibition of tumor growth is observed in immunocompetent mice when GLS is knocked down. It is found that GLS knockdown in CRC cells enhanced the cytotoxicity of tumor-specific T cells. Furthermore, the single-cell flux estimation analysis (scFEA) of glutamine metabolism revealed that glutamate-to-glutathione (Glu-GSH) flux, downstream of GLS, rather than Glu-to-2-oxoglutarate flux plays a key role in regulating the immune response of CRC cells in the tumor. Mechanistically, inhibition of the Glu-GSH flux activated reactive oxygen species (ROS)-related signaling pathways in tumor cells, thereby increasing the tumor immunogenicity by promoting the activity of the immunoproteasome. The combinatorial therapy of Glu-GSH flux inhibitor and anti-PD-1 antibody exhibited a superior tumor growth inhibitory effect compared to either monotherapy. Taken together, the study provides the first evidence pointing to Glu-GSH flux as a potential therapeutic target for CRC immunotherapy.}, archive = {J_ADVS}, author = {Tao Yu and Kevin Van der Jeught and Haiqi Zhu and Zhuolong Zhou and Samantha Sharma and Sheng Liu and Haniyeh Eyvani and Ka Man So and Naresh Singh and Jia Wang and George E. Sandusky and Yunlong Liu and Mateusz Opyrchal and Sha Cao and Jun Wan and Chi Zhang and Xinna Zhang}, doi = {10.1002/advs.202310308}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2310308}, shortjournal = {Adv. Sci.}, title = {Inhibition of glutamate-to-glutathione flux promotes tumor antigen presentation in colorectal cancer cells}, volume = {12}, year = {2025}, }
• (2025). Landscape of the peripheral immune response induced by intraoperative radiotherapy combined with surgery in early breast cancer patients. ADVS, 12(1), 2308174. (www)

  @article{ , abstract = {A comprehensive analysis of the immune response triggered by intraoperative radiation therapy (IORT) remains incomplete. In this study, single-cell RNA sequencing and single-cell T cell receptor sequencing are conducted on peripheral blood mononuclear cells (PBMCs) from patient with early-stage breast cancer before and after IORT. Following IORT combined with surgery (defined as IORT+Surgery), PBMC counts remained stable, with increased proportions of T cells, mononuclear phagocytes, and plasma cells, and a reduction in neutrophil proportions. The cytotoxic score of CD8Teff_GZMK cells increased significantly post-IORT. Communication between CD8Teff_GZMK cells and other immune cells via MIF_CD74 and MIF_TNFRSF14 is decreased after IORT. cDCs showed an upregulation of the MCH II signaling pathway, while memory B cells exhibited enhanced activation of the B cell pathway. T cell clones expanded significantly after treatment. IORT+Surgery demonstrated the ability to partially suppress the anti-tumor effects of neutrophils. Flow cytometry analysis and co-culture experiments are utilized to delve deeper into the functional alterations in T cells. IORT+Surgery significantly enhanced T cell cytotoxic activity. Blockade of PD-1 of post-IORT PBMCs shows higher T-cell activity than that of pre-IORT PBMCs. This research highlights IORT's impact on immune cells, offering insights for targeting immune responses in breast cancer.}, archive = {J_ADVS}, author = {Danian Dai and Xuerui Li and Hongkai Zhuang and Yun Ling and Lezi Chen and Cheng Long and Jinhui Zhang and Yunjie Wang and Yuehua Li and Hailin Tang and Bo Chen}, doi = {10.1002/advs.202308174}, journal = {Advanced Science}, month = {1}, number = {1}, pages = {2308174}, shortjournal = {Adv. Sci.}, title = {Landscape of the peripheral immune response induced by intraoperative radiotherapy combined with surgery in early breast cancer patients}, volume = {12}, year = {2025}, }